id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-289382-bnl9i9oy	Wright, Gerard D	Q&A: Antibiotic resistance: where does it come from and what can we do about it?	2010-09-20		.txt	text/plain	3361	160	35	• the spread of virulent MRSA (methicillin-resistant Staphylococcus aureus) in the community; • the rise of multi-drug resistant Neisseria gonorrhoea; • the emergence and global dissemination of multi-drug resistant Acinetobacter baumannii, Pseudomonas aerugi nosa, Klebsiella pneumoniae and Enterobacteriaceae; • the spread of extensively drug resistant Mycobacterium tuberculosis; • the development of resistance to the two newest antibiotics to be approved for clinical use -daptomycin and linezolid. Microbial natural products have evolved over millennia to interact with biological molecules, whereas the synthetic chemical libraries used in antibiotic drug-discovery screens were generally developed with a focus on eukaryotic drug-discovery campaigns, as noted earlier. Efforts to develop physical-property rules for antibiotics and to incorporate natural-product-like chemical complexity in libraries of synthetic chemicals will no doubt improve success in identifying new synthetic antibiotic leads. Furthermore, natural-product producing bacteria from non-soil environments are being investigated and these have already resulted in new chemical matter, suggesting that there is a fantastic wealth of untapped chemical diversity waiting to be discovered.	./cache/cord-289382-bnl9i9oy.txt	./txt/cord-289382-bnl9i9oy.txt