id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-349300-x50tvq3a	de Wit, Emmie	Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection	2020-03-24		.txt	text/plain	4533	217	44	Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV−induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. Prophylactic remdesivir treatment initiated 24 h prior to inoculation completely prevented MERS-CoV−induced clinical disease, strongly inhibited MERS-CoV replication in respiratory tissues, and prevented the formation of lung lesions. Compared to vehicle-treated control animals, prophylactic remdesivir treatment resulted in significantly lower levels of MERS-CoV replication in the lungs, with lung viral loads 2.5 to 4 logs lower in each lung lobe (Fig. 3A) . Absence of histologic lung lesions, as seen in two out of the six animals with therapeutic remdesivir treatment, has so far rarely been observed in studies testing the efficacy of MERS-CoV antivirals in nonhuman primate models (13) (14) (15) (16) ; it has only been shown once before in one out of three common marmosets treated with hyperimmune plasma at 6 h after inoculation (17) .	./cache/cord-349300-x50tvq3a.txt	./txt/cord-349300-x50tvq3a.txt