id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-341263-j4ribasg	Gjerde, Eli-Anne B	Problems in physiological experimental animal models investigated with factorial design	2004-04-30		.txt	text/plain	4373	222	51	Abstract In the present study we investigated four variables using factorial design to decide if any of these could explain the variations in the control measurements of interstitial fluid pressure (P if) in rat trachea that were experienced. The experiments were performed since interstitial fluid pressure (P if ) in rat trachea in control animals was observed to be lowered, a response otherwise seen in acute inflammatory reactions such as following mast cell degranulation and neurogenic inflammation (Koller and Reed, 1992; Koller et al., 1993; Woie et al., 1993; Woie and Reed, 1994) . Under normal (non-inflammatory) conditions P if is slightly subatmospheric and the mean average and standard deviation measured over 60 or 90 min registration period for trachea is À1.45 7 0.36 mmHg. This average is taken from a total of 13 studies and 17 series of experiments containing all together 132 control animals giving a average of 7-8 animals per series (Gjerde et al., 1997 (Gjerde et al., , 2000 (Gjerde et al., , 2002 (Gjerde et al., , 2003 Koller and Reed, 1992; Koller et al., 1993; Wei et al., 1998; Woie et al., 1993 Woie and Reed, 1994 .	./cache/cord-341263-j4ribasg.txt	./txt/cord-341263-j4ribasg.txt