id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340939-ikomc19t	van Doremalen, Neeltje	A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters	2019-06-06		.txt	text/plain	5486	301	52	title: A single-dose ChAdOx1-vectored vaccine provides complete protection against Nipah Bangladesh and Malaysia in Syrian golden hamsters Prime-only as well as prime-boost vaccination resulted in uniform protection against a lethal challenge with NiV Bangladesh: all animals survived challenge and we were unable to find infectious virus either in oral swabs, lung or brain tissue. All vaccinated animals challenged with NiV Malaysia survived with no signs of disease such as weight loss at any stage throughout the experiment. An adeno-associated virus vaccine expressing NiV G protein offered 50% protection against a lethal challenge with HeV in hamsters [46] . Furthermore, infectious virus could only be detected in the lungs of control animals and not in the lungs of vaccinated animals, and thus as in previous studies, ChAdOx1 NiV Belicited antibodies are able to provide protection against a lethal challenge with NiV.	./cache/cord-340939-ikomc19t.txt	./txt/cord-340939-ikomc19t.txt