id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-343736-htwlfqos	Liu, Qiang	miRNA-200c-3p is crucial in acute respiratory distress syndrome	2017-06-27		.txt	text/plain	5500	320	48	Therefore, we identify a shared mechanism of viral and bacterial lung infection-induced ALI/ARDS via nuclear factor-κB-dependent upregulation of miR-200c-3p to reduce ACE2 levels, which leads increased angiotensin II levels and subsequently causes lung injury. Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is the main predisposing factor in highly pathogenic avian influenza virus-induced death cases [1, 2] . Additionally, the ACE2 protein expression levels were downregulated in A549 cells (Supplementary Figure S1e) and HEK293T cells (Supplementary Figure S1f) after infection with H5N1 influenza virus, which were consistent with our previous observations in the H5N1-infected mice lung tissues [16] . Our study indicates that miR-200c-3p has a crucial role in the regulation of ACE2 in ALI or ARDS induced by H5N1 virus infection and severe pneumonia.	./cache/cord-343736-htwlfqos.txt	./txt/cord-343736-htwlfqos.txt