id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-342478-2k2eb1rk	Ogunlade, Blessing	The Actin Bundling Protein Fascin-1 as an ACE2-Accessory Protein	2020-08-31		.txt	text/plain	4829	266	50	We have previously shown that angiotensin-converting enzyme 2 (ACE2), an enzyme counterbalancing the deleterious effects of angiotensin type 1 receptor activation by production of vasodilatory peptides Angiotensin (Ang)-(1–9) and Ang-(1–7), is internalized and degraded in lysosomes following chronic Ang-II treatment. In conclusion, we identified fascin-1 as an ACE2-accessory protein, interacting with the enzyme in an Ang-II dependent manner and contributing to the regulation of enzyme activity. Our group originally demonstrated that Ang-II induces ACE2 internalization and degradation into lysosomes through an Ang-II type 1 receptor (AT 1 R)-dependent mechanism and this process leads to a decrease in the expression levels and activity of the enzyme (Deshotels et al. In the present work, we identify fascin-1 as the only protein which in HEK293T cells has differential interactions with ACE2 after 4 h treatment with Ang-II, a time point that coincides with the lysosomal targeting of this enzyme (Deshotels et al.	./cache/cord-342478-2k2eb1rk.txt	./txt/cord-342478-2k2eb1rk.txt