id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340581-ngwgb3y0	Abassi, Zaid	ACE2, COVID-19 Infection, Inflammation, and Coagulopathy: Missing Pieces in the Puzzle	2020-10-06		.txt	text/plain	4644	247	42	Angiotensin-converting enzyme is expressed on the plasma membranes of various cell types, including alveolar and intestinal epithelia, vascular endothelial cells in the heart, kidney, and testis, and on macrophages, where it catalyzes the production of Ang 1-7 and its likely paracrine activity (Crackower et al., 2002; Hamming et al., 2007; Santos et al., 2008; Clarke and Turner, 2012; Abassi et al., 2020c) . In this context, testosterone has been described to induce ACE2 expression, the receptor entry of the SARS-CoV-2 infection, but also exerts protective effect against lung injury (Kuba et al., 2005) . FIGURE 2 | Physiology of coronavirus disease 2019 (COVID 19) homing to target host cells expressing ACE2: viral spike-domains enable attachment to cellmembrane-bound ACE2. Thus, viral cellular invasion and replication, initially facilitated by ACE2 and in particular under conditions characterized by enhanced ACE2 expression, later lead to diminution of cell membrane-attached ACE2, and likely increase circulating sACE2 (Figures 2, 3) .	./cache/cord-340581-ngwgb3y0.txt	./txt/cord-340581-ngwgb3y0.txt