id author title date pages extension mime words sentences flesch summary cache txt cord-304976-egbl3ljp Allen, A.M. Neuronal Angiotensin 2008-11-05 .txt text/plain 3668 171 42 Within the brain renin, some questions remain as to how the precursor, angiotensinogen, and its processing enzymes interact to produce the active compounds, angiotensin II/III, because they are rarely localized to the same brain nucleus let alone the same cell. Further work throughout the 1900s defined a humoral system in which the active agent, angiotensin (Ang II), was derived from a protein precursor, angiotensinogen (Aogen), via the sequential action of two enzymes, renin and angiotensin converting enzyme (ACE) (Figure 1 ). It has since been demonstrated that many tissues, including kidney, heart, blood vessels, adrenal gland, uterus, testes, and brain, have the potential to produce Ang independently of the circulating renin-angiotensin system. Some of the most convincing evidence for the existence of a brain renin-angiotensin system is derived from examination of the distribution of the Ang receptors and the physiological actions exerted through them. ./cache/cord-304976-egbl3ljp.txt ./txt/cord-304976-egbl3ljp.txt