id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-303394-iqepytyd	Han, Su-Xia	Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: Possible involvement of angiotensin-converting enzyme-2	2010-05-15		.txt	text/plain	5132	254	47	title: Losartan attenuates chronic cigarette smoke exposure-induced pulmonary arterial hypertension in rats: Possible involvement of angiotensin-converting enzyme-2 Elevated right ventricular systolic pressure (RVSP), thickened wall of pulmonary arteries with apparent medial hypertrophy along with increased angiotensin II (Ang II) and decreased ACE2 levels were observed in smoke-exposed-only rats. Consistent with the in vivo study, in vitro losartan pretreatment also inhibited cigarette smoke extract (CSE)-induced cell proliferation and ACE2 reduction in rat PASMCs. The results suggest that losartan may be therapeutically useful in the chronic smoking-induced pulmonary vascular remodeling and PAH and ACE2 may be involved as part of its mechanism. These results were consistent with our findings in the in vivo study that losartan treatment may attenuate chronic smoking-induced pulmonary artery remodeling and ACE2 reduction in rat lungs. In our present study, we found that ACE2 protein expression was significantly decreased in the lung along with apparent pulmonary arterial remodeling and PAH in the 6-month smoke-exposed rats.	./cache/cord-303394-iqepytyd.txt	./txt/cord-303394-iqepytyd.txt