id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-299960-ounktxxv	Varagic, Jasmina	New angiotensins	2008-04-25		.txt	text/plain	5360	255	41	Interestingly, the spectrum of novel peptides within RAS continues to expand showing that a peptide containing two amino acids more than Ang I, the dodecapeptide angiotensin(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) [Ang(1) (2) (3) (4) (5) (6) (7) (8) (9) (10) (11) (12) ; rat sequence: Asp 1 -Arg 2 -Val 3 -Tyr 4 -Ile 5 -His 6 -Pro 7 -Phe 8 -His 9 -Leu 10 -Leu 11 -Tyr 12 ], could also be a key player in the regulation of cardiovascular function. Together with evidence for increased ACE2 expression in failing human [21] and rat [22] hearts, our study suggests a preserved compensatory response of injured hearts to maintain Ang-(1-7) levels even in the advanced stage of the disease, although it was obviously not sufficient to counteract the deleterious effects of Ang II. Collectively, these data provide strong evidence that Ang-(1-12) may be an alternate precursor substrate for the formation of bioactive angiotensin peptides in the heart, kidney, and circulation that may depend on the localization of one of its processing enzymes, ACE, but not renin.	./cache/cord-299960-ounktxxv.txt	./txt/cord-299960-ounktxxv.txt