id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-278265-hgggkr5y	Hisatake, Shinji	The serum angiotensin-converting enzyme 2 and angiotensin-(1-7) concentrations after optimal therapy for acute decompensated heart failure with reduced ejection fraction	2020-06-15		.txt	text/plain	3612	192	46	No previous study has reported serial changes in ACE2 and Ang-(1-7) concentrations after optimal therapy (OT) in acute heart failure (AHF) patients. Results: In the acute phase, Ang-(1-7) and ACE2 concentrations was statistically significantly lower and higher in AHF patients than the healthy individuals (2.40 ± 1.11 vs. We previously reported that acute heart failure (AHF) patients requiring hospitalization had higher serum ACE2 and lower Ang-(1-7) concentrations in the acute phase when compared with the concentrations in healthy volunteers [13] . The present study aimed to investigate the serial changes in the serum ACE2 and Ang-(1-7) concentrations after OT in AHF patients requiring inpatient care. The primary end points of the present study were the serum Ang-(1-7) and ACE2 concentrations at 1 and 3 months later after OT in the patients were compared with the healthy individuals. At 3 months after OT, the statistically significant difference in the serum Ang-(1-7) concentration between heart failure patients and the healthy individuals disappeared.	./cache/cord-278265-hgggkr5y.txt	./txt/cord-278265-hgggkr5y.txt