id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-276192-sgts963l	Simões e Silva, Ana Cristina	2020 update on the renin–angiotensin–aldosterone system in pediatric kidney disease and its interactions with coronavirus	2020-09-29		.txt	text/plain	13084	667	41	The alternative axis, however, is activated mostly due to Ang-(1-7) binding to Mas receptors, promoting counter-regulatory actions, including decrease of SNS tone, of blood pressure, and of cardiac hypertrophy; increase of baroreflex sensitivity, of NO release, and of natriuresis; and stimulation of vasodilatation. Once activated, the ACE/Ang II/AT1R axis triggers many systemic and local actions which include (1) increased aldosterone production, (2) stimulation of anti-diuretic hormone (ADH) production [31] , (3) activation of sympathetic nervous system (SNS) tone, (4) elevation of BP (5) vasoconstriction, (6) cardiac hypertrophy, (7) fibrosis, (8) inflammation, (9) vascular smooth muscle cell (VSMC) dedifferentiation, (10) reactive oxygen species (ROS) production [32] , and (11) tissue injury. In inflammatory diseases, including arthritis, acute lung injury, asthma, and diabetic nephropathy, several studies have concluded that (1) Ang-(1-7) reduced leukocyte recruitment and the production and expression of chemokines, cytokines, and adhesion molecules and (2) the Mas receptor increased neutrophil apoptosis and stimulated the alternative macrophage activation [12] .	./cache/cord-276192-sgts963l.txt	./txt/cord-276192-sgts963l.txt