id author title date pages extension mime words sentences flesch summary cache txt cord-275676-fsumpj4n Kintscher, Ulrich Plasma Angiotensin Peptide Profiling and ACE (Angiotensin-Converting Enzyme)-2 Activity in COVID-19 Patients Treated With Pharmacological Blockers of the Renin-Angiotensin System 2020-09-08 .txt text/plain 1242 73 49 title: Plasma Angiotensin Peptide Profiling and ACE (Angiotensin-Converting Enzyme)-2 Activity in COVID-19 Patients Treated With Pharmacological Blockers of the Renin-Angiotensin System P harmacological blockade of the renin-angiotensin system (RAS) with ACE (angiotensin-converting enzyme) inhibitors or angiotensin type 1 receptor blockers (ARB) reduces morbidity and mortality in various cardiovascular diseases. Ang-peptide equilibrium concentrations did not significantly differ between the CTRL and COVID groups without ACE inhibitor/ARB treatment (Figure [B] , left). Ang I+II is a reliable marker for plasma renin activity and did not change significantly, despite the use of ACE inhibitor/ ARB, while median values were clearly increased in patients on ACE inhibitor/ARB. 4 As expected, patients in the CTRL-ACE inhibitor and COVID-ACE inhibitor group showed increased Ang I and markedly suppressed Ang II levels (Figure [B] ), resulting in a significant reduction of the Ang II/Ang I ratio (Figure [C] , lower left). ./cache/cord-275676-fsumpj4n.txt ./txt/cord-275676-fsumpj4n.txt