id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252193-pgr07l9b	Sato, Teruki	Loss of Apelin Augments Angiotensin II-Induced Cardiac Dysfunction and Pathological Remodeling	2019-01-09		.txt	text/plain	4707	261	52	The loss of apelin increased the ratio of angiotensin-converting enzyme (ACE) to ACE2 expression in the Ang II-stressed hearts, and Ang II-induced cardiac fibrosis was markedly enhanced in apelin knockout mice. Wild type (WT) and apelin knockout (Apelin KO) mice at 12 months of age were continuously infused with either vehicle or angiotensin II (Ang II) for 2 weeks using osmotic minipumps (Ang II, 1 mg/kg/day) and measured for blood pressure using the tail-cuff method. While endogenous apelin antagonizes Ang II-induced heart pathology and upregulates ACE2 expression, it is interesting to observe that Ang II-stimulated elevation of blood pressure was not further increased in Apelin KO mice but comparable to WT mice. While endogenous apelin antagonizes Ang II-induced heart pathology and upregulates ACE2 expression, it is interesting to observe that Ang II-stimulated elevation of blood pressure was not further increased in Apelin KO mice but comparable to WT mice.	./cache/cord-252193-pgr07l9b.txt	./txt/cord-252193-pgr07l9b.txt