id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-026680-ksacxsdk	Shoieb, Sherif M.	Resveratrol attenuates angiotensin II-induced cellular hypertrophy through the inhibition of CYP1B1 and the cardiotoxic mid-chain HETE metabolites	2020-06-12		.txt	text/plain	6379	339	50	Several reports demonstrated the direct contribution of cytochrome P450 1B1 (CYP1B1) enzyme and its associated cardiotoxic mid-chain, hydroxyeicosatetraenoic acid (HETEs) metabolites in the development of cardiac hypertrophy. 2,3′,4,5′-tetramethoxystilbene (TMS), a well-known CYP1B1 inhibitor, was able to significantly decrease the level of mid-chain HETEs and protect against angiotensin II (Ang II)-induced cardiac hypertrophy [17] . Therefore, the purpose of this study is to investigate whether resveratrol protects against Ang II-induced cellular hypertrophy through inhibition of CYP1B1/mid-chain HETEs mechanism. We examined whether different concentrations of resveratrol have a protective effect against Ang II-induced cellular hypertrophy through inhibiting the protein expression of CYP1B1. Resveratrol at concentration of 10 μM significantly inhibited Ang II-mediated increase of the metabolite formation rate of Fig. 4 Effect of resveratrol on mRNA expression and protein expression levels of CYP1B1 in H9c2 cells.	./cache/cord-026680-ksacxsdk.txt	./txt/cord-026680-ksacxsdk.txt