id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007267-r3gfr1gk	Kondo, Masateru	Xanthine Oxidase Inhibition by Febuxostat in Macrophages Suppresses Angiotensin II-Induced Aortic Fibrosis	2018-10-23		.txt	text/plain	3430	218	51	CONCLUSIONS: Our results suggested that FEB ameliorates Ang II-induced aortic fibrosis via suppressing macrophage-derived TGF-β1 expression. In this study, we used a mouse model of hypertension induced by Ang II characterized by aortic fibrosis and macrophage accumulation 18 to investigate the effects of a XO inhibitor, FEB, on the pathogenesis of vascular remodeling independent of the level of uric acid. Our results suggested that FEB inhibited Ang II-induced transforming growth factor (TGF)-β1 expression in macrophages and suppressed fibrotic processes in aortae. These results suggested that the suppressive effects of FEB on Ang II-induced aortic fibrosis and blood pressure elevation were independent of the circulating uric acid level. the results indicating the suppressive effects of FEB on Ang II-induced macrophage-derived TGF-β1 mRNA expression. In the present study, we concluded that FEB suppressed Ang II-induced vascular fibrosis, via mainly inhibiting the TGF-β1 expression in the accumulated macrophages in the adventitia, as its additive effects outside of ameliorating hyperuricemia.	./cache/cord-007267-r3gfr1gk.txt	./txt/cord-007267-r3gfr1gk.txt