id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006439-q7m4srvp	Nakagawa, Pablo	The Renin-Angiotensin System in the Central Nervous System and Its Role in Blood Pressure Regulation	2020-01-10		.txt	text/plain	6450	281	33	Central administration of ANG-II elicits potent dipsogenic responses, induces sodium intake, triggers sympathetic outflow to the kidney and other organs, and recently, evidence has established that the brain RAS modulates metabolic function primarily through distinct nuclei within the hypothalamus [14] [15] [16] [17] . In the final section of this article, we will discuss how the development of state-of-the-art technology to study precise molecular signaling and neuronal circuits within the CNS are appropriate to elucidate the key mechanisms regulating generation and action of angiotensin peptides within different neuroanatomical regions. Intracerebroventricular infusion of ACE inhibitor prevents and reverses high blood pressure, demonstrating that production of ANG-II in the brain is required for DOCA-salt hypertension even though circulating RAS activity is suppressed [71] . Therefore, the development of novel drugs modulating the brain RAS might represent an effective solution to treat resistant hypertension coincident with elevated sympathetic activity and suppressed circulating renin activity.	./cache/cord-006439-q7m4srvp.txt	./txt/cord-006439-q7m4srvp.txt