id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-340865-sut3nf2a	Wang, Shuang	Blockage of P2X7 attenuates acute lung injury in mice by inhibiting NLRP3 inflammasome	2015-04-29		.txt	text/plain	3587	221	51	LPS administration increased P2X7 expression in the lung parenchyma and P2X7 −/− mice showed decreased polymorphonuclear cell infiltration, less inflammatory cytokine production and reduced collagen deposition [8] . In this study, we demonstrated that pharmacological blockade of P2X7 by using selective antagonists effectively ameliorated ALI in mice via inhibiting NLRP3 inflammasome pathway. Enhanced protein expression of P2X7, NLRP3, and ASC was observed in the lungs from LPS-induced lung injury mice compared with control mice treated by PBS (Fig. 1) . Coincident with the cell counts, the total protein level was also elevated in the LPS-induced lung injury group, which was significantly reduced by A438079 treatment (Fig. 3d) . In this study, P2X7 expression was significantly enhanced at the protein level in the lung tissues from ALI mice, paralleled with alveolar damage and inflammatory cytokine production. We found that blockage of P2X7 inhibited the activation of NLRP3 inflammasome pathway, neutrophil accumulation and production of proinflammatory cytokines, resulting in reduction of lung damage.	./cache/cord-340865-sut3nf2a.txt	./txt/cord-340865-sut3nf2a.txt