id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-334528-xenq90xj	Chen, Hsing I	Acute lung injury and acute respiratory distress syndrome: experimental and clinical investigations	2011-03-17		.txt	text/plain	5307	380	37	This literature review includes a brief historical retrospective of ALI/ARDS, the neurogenic pulmonary edema due to head injury, the long-term experimental studies and clinical investigations from our laboratory, the detrimental role of NO, the risk factors, and the possible pathogenetic mechanisms as well as therapeutic regimen for ALI/ARDS. [33, 34] In addition to the aforementioned animal experimentations and clinical observations that NO production through the iNOS may be involved in the lung injury due to various causes, our research team demonstrated that endotoxemia produced in anesthetized rats by intravenous administration of lipopolysaccharide (LPS, endotoxin) provoked systemic hypotension, endothelial damage and ALI accompanied by increased plasma nitrate/nitrite and expression of iNOS mRNA, TNF α and IL-1 β . The detrimental role of inducible nitric oxide synthase in the pulmonary edema caused by hypercalcemia in conscious rats and isolated lungs	./cache/cord-334528-xenq90xj.txt	./txt/cord-334528-xenq90xj.txt