id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-017853-mgsuwft0	Machado, Roberto F.	Genomics of Acute Lung Injury and Vascular Barrier Dysfunction	2010-06-28		.txt	text/plain	9177	397	32	In this chapter, we utilize a systems biology approach combining cellular signaling pathway analysis with population-based association studies to review established and suspected candidate genes that contribute to dysfunction of endothelial cell barrier integrity and ALI susceptibility. Genes encoding proinflammatory cytokines, growth factors and mediators, receptors for barrier-regulatory agonists, and mechanical-stress-sensitive genes expressed in endothelium which regulate inflammatory responses also serve as attractive ALI candidate genes and are representative of the diverse but fertile areas of exploration for candidate SNPs affecting ALI susceptibility and severity. Interrogating the prospective pathways involved in endothelial permeability and correlation with these differentially expressed genes in VALI models identified the most putative ALI genes such as myosin light chain kinase (MYLK), sphingosine 1-phosphate receptor 1, cMet, and vascular endothelial growth factor (VEGF) mechanical stress [37, 38] . Role of macrophage migration inhibitory factor (MIF) in human and animal models of acute lung injury (ALI) and sepsis: association of a promoter polymorphism and increased gene expression	./cache/cord-017853-mgsuwft0.txt	./txt/cord-017853-mgsuwft0.txt