id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006573-mwtqxwbw	Zhang, Leifang	SOCS-1 Suppresses Inflammation Through Inhibition of NALP3 Inflammasome Formation in Smoke Inhalation-Induced Acute Lung Injury	2018-06-16		.txt	text/plain	4684	294	48	title: SOCS-1 Suppresses Inflammation Through Inhibition of NALP3 Inflammasome Formation in Smoke Inhalation-Induced Acute Lung Injury Similar to oxidized ATP, high protein level of SOCS-1 dampened the formation of NALP3 inflammasome and the activation of caspase-1 and IL-1β induced by smoke exposure in mouse alveolar macrophages. In conclusion, SOCS-1 relieves smoke inhalation-induced pulmonary inflammation and injury by inhibiting NALP3 inflammasome formation. To test whether SOCS-1 exerts anti-inflammatory effect through inhibition of NALP3 inflammasome formation and consequent activation of caspase-1 and IL-1β, Ad-GFP, or Ad-SOCS-1-adminstered mice were exposed to smoke for 15 min and euthanized 1 day later to collect alveolar macrophages. Alveolar macrophages were isolated from C57BL/6 mice, treated with or without oxATP, exposed to smoke for 30 min, and then analyzed for a ATP release, b extracellular, and c intracellular K + levels, d expression of inflammasome components NALP3, ASC, and caspase-1, and e the complex formed by NALP3 and ASC.	./cache/cord-006573-mwtqxwbw.txt	./txt/cord-006573-mwtqxwbw.txt