id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006507-amo8e81h	Yang, Zhongwei	TLR4 as receptor for HMGB1-mediated acute lung injury after liver ischemia/reperfusion injury	2013-04-29		.txt	text/plain	5597	306	51	This study investigated whether HMGB1 was involved as a stimulating factor, and whether its downstream Toll-like receptor 4 (TLR4), p38 mitogen-activated protein kinase (p38MAPK), and activator protein-1 (AP-1) signaling pathways act as mediators in the development of liver I/R injury-induced ALI. To study the role of TLR4 and its downstream p38MAPK and AP-1 signaling pathways in the pathogenesis of liver I/R injury-induced ALI, TLR4-small hairpin RNA (shRNA) lentivirus were used to inhibit TLR4 expression in rat lung tissue. As is shown in Figure 3b , relative levels of HMGB1 mRNA in the lung tissue from I/R, shNT þ I/R, and shTLR4 þ I/R groups increased significantly at 18 h after liver I/R injury when compared to the control group, respectively. TLR4-mediated ALI after liver I/R injury Z Yang et al Figure 3 Expression of high-mobility group box protein 1 (HMGB1) in serum and lung tissue from rats at 18 h after liver ischemia/reperfusion (I/R) injury or sham operation.	./cache/cord-006507-amo8e81h.txt	./txt/cord-006507-amo8e81h.txt