id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-005812-hx6lkuj0	Morty, Rory E.	Alveolar fluid clearance in acute lung injury: what have we learned from animal models and clinical studies?	2007-05-25		.txt	text/plain	6230	313	37	To complement that report this review focuses on how intact organ and animal models and clinical studies have facilitated our understanding of alveolar edema fluid clearance in acute lung injury and acute respiratory distress syndrome. Given the established importance of the type II cell in AFC [6] and the emerging importance of the type I cell in AFC with the recent discovery that type I cells also contain functional sodium and chloride channels [12] , this epithelial damage Fig. 1 Factors that cause impaired alveolar fluid clearance in ALI/ARDS that have been investigated in animal and organ models and in clinical studies. This idea was further supported by the observations that adenovirus-mediated transfer of β-adrenergic receptor genes to live rats improved AFC due to increased sensitivity to endogenous catecholamines and consequent upregulation of Na,K-ATPase activity and ENaC protein expression the lung [73] .	./cache/cord-005812-hx6lkuj0.txt	./txt/cord-005812-hx6lkuj0.txt