id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-001020-2iwsx727	Gupta, Kushagra	Adipose-derived stem cells weigh in as novel therapeutics for acute lung injury	2013-02-28		.txt	text/plain	1359	74	53	Herein, we discuss the advantages and potential limitations of using adipose-derived stem cells as therapeutics for human acute lung injury. A strength of the paper is its novel focus on ASCs as a therapy for ALI, and its approach to test ASCs therapeutically (rather than prophylactically) in an ALI model Abstract Acute lung injury is characterized by intense neutrophilic lung infl ammation and increased alveolar-capillary barrier permeability leading to severe hypoxemia, and is associated with high mortality despite improvements in supportive care. Zhang and colleagues tested the effi cacy of adipose-derived stem cells in acute lung injury in mice. While the LPS model studied by Zhang and coworkers induces robust neutrophilic lung infl ammation, it causes only modest alveolar-capillary barrier injury, which is a hallmark of ALI/ARDS. Comparison of the therapeutic eff ects of human and mouse adipose-derived stem cells in a murine model of lipopolysaccharide-induced acute lung injury	./cache/cord-001020-2iwsx727.txt	./txt/cord-001020-2iwsx727.txt