id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-000137-idffrnac	Xiang, Meng	Pattern Recognition Receptor–Dependent Mechanisms of Acute Lung Injury	2009-11-02		.txt	text/plain	9097	456	40	The study further found that the induction of the negative regulators of TLR signaling IL-1R-associated kinase-M, Toll-interacting protein and A20 by intratracheal LPS in vivo and in macrophages in vitro was significantly reduced in CD44 -/mice. Thus, the study demonstrates a novel mechanism underlying HS-augmented lung inflammation, namely that induction of increased TLR2 surface expression in lung endothelial cells, which is induced by HS/R and mediated by HMGB1 activation of TLR4 signaling, is an important mechanism responsible for EC-mediated inflammation and organ injury following HS (122) . These results provide evidence for direct activation of the NLRP3 inflammasome by biglycan and suggest a fundamental paradigm of how tissue stress and injury are monitored by innate immune receptors detecting the release of the extracellular matrix components and turning such a signal into a robust inflammatory response (147) .	./cache/cord-000137-idffrnac.txt	./txt/cord-000137-idffrnac.txt