id sid tid token lemma pos cord-009561-pg4jmvw4 1 1 key key NN cord-009561-pg4jmvw4 1 2 : : : cord-009561-pg4jmvw4 2 1 cord-009561-pg4jmvw4 cord-009561-pg4jmvw4 NNP cord-009561-pg4jmvw4 2 2 authors author NNS cord-009561-pg4jmvw4 2 3 : : : cord-009561-pg4jmvw4 2 4 Johnson Johnson NNP cord-009561-pg4jmvw4 2 5 , , , cord-009561-pg4jmvw4 2 6 Richard Richard NNP cord-009561-pg4jmvw4 2 7 T. T. NNP cord-009561-pg4jmvw4 2 8 title title NN cord-009561-pg4jmvw4 2 9 : : : cord-009561-pg4jmvw4 2 10 The the DT cord-009561-pg4jmvw4 2 11 virology virology NN cord-009561-pg4jmvw4 2 12 of of IN cord-009561-pg4jmvw4 2 13 demyelinating demyelinating JJ cord-009561-pg4jmvw4 2 14 diseases disease NNS cord-009561-pg4jmvw4 2 15 date date NN cord-009561-pg4jmvw4 2 16 : : : cord-009561-pg4jmvw4 2 17 2004 2004 CD cord-009561-pg4jmvw4 2 18 - - SYM cord-009561-pg4jmvw4 2 19 10 10 CD cord-009561-pg4jmvw4 2 20 - - HYPH cord-009561-pg4jmvw4 2 21 08 08 CD cord-009561-pg4jmvw4 2 22 journal journal NN cord-009561-pg4jmvw4 2 23 : : : cord-009561-pg4jmvw4 3 1 Ann Ann NNP cord-009561-pg4jmvw4 3 2 Neurol Neurol NNP cord-009561-pg4jmvw4 3 3 DOI DOI NNP cord-009561-pg4jmvw4 3 4 : : : cord-009561-pg4jmvw4 4 1 10.1002 10.1002 CD cord-009561-pg4jmvw4 4 2 / / SYM cord-009561-pg4jmvw4 4 3 ana.410360715 ana.410360715 NNP cord-009561-pg4jmvw4 4 4 sha sha NNP cord-009561-pg4jmvw4 4 5 : : : cord-009561-pg4jmvw4 5 1 cfce26dbaf9f434ece243b3ce192ffcb8bc23b3c cfce26dbaf9f434ece243b3ce192ffcb8bc23b3c CC cord-009561-pg4jmvw4 5 2 doc_id doc_id CD cord-009561-pg4jmvw4 6 1 : : : cord-009561-pg4jmvw4 6 2 9561 9561 CD cord-009561-pg4jmvw4 6 3 cord_uid cord_uid NNS cord-009561-pg4jmvw4 6 4 : : : cord-009561-pg4jmvw4 7 1 pg4jmvw4 pg4jmvw4 NNP cord-009561-pg4jmvw4 7 2 Infectious infectious JJ cord-009561-pg4jmvw4 7 3 agents agent NNS cord-009561-pg4jmvw4 7 4 have have VBP cord-009561-pg4jmvw4 7 5 been be VBN cord-009561-pg4jmvw4 7 6 postulated postulate VBN cord-009561-pg4jmvw4 7 7 as as IN cord-009561-pg4jmvw4 7 8 causes cause NNS cord-009561-pg4jmvw4 7 9 of of IN cord-009561-pg4jmvw4 7 10 multiple multiple JJ cord-009561-pg4jmvw4 7 11 sclerosis sclerosis NN cord-009561-pg4jmvw4 7 12 for for IN cord-009561-pg4jmvw4 7 13 over over IN cord-009561-pg4jmvw4 7 14 a a DT cord-009561-pg4jmvw4 7 15 century century NN cord-009561-pg4jmvw4 7 16 . . . cord-009561-pg4jmvw4 8 1 The the DT cord-009561-pg4jmvw4 8 2 possible possible JJ cord-009561-pg4jmvw4 8 3 role role NN cord-009561-pg4jmvw4 8 4 of of IN cord-009561-pg4jmvw4 8 5 a a DT cord-009561-pg4jmvw4 8 6 virus virus NN cord-009561-pg4jmvw4 8 7 or or CC cord-009561-pg4jmvw4 8 8 viruses virus NNS cord-009561-pg4jmvw4 8 9 is be VBZ cord-009561-pg4jmvw4 8 10 supported support VBN cord-009561-pg4jmvw4 8 11 by by IN cord-009561-pg4jmvw4 8 12 data datum NNS cord-009561-pg4jmvw4 8 13 that that WDT cord-009561-pg4jmvw4 8 14 ( ( -LRB- cord-009561-pg4jmvw4 8 15 1 1 CD cord-009561-pg4jmvw4 8 16 ) ) -RRB- cord-009561-pg4jmvw4 9 1 a a DT cord-009561-pg4jmvw4 9 2 childhood childhood NN cord-009561-pg4jmvw4 9 3 exposure exposure NN cord-009561-pg4jmvw4 9 4 is be VBZ cord-009561-pg4jmvw4 9 5 involved involve VBN cord-009561-pg4jmvw4 9 6 and and CC cord-009561-pg4jmvw4 9 7 “ " `` cord-009561-pg4jmvw4 9 8 viral viral JJ cord-009561-pg4jmvw4 9 9 ” " '' cord-009561-pg4jmvw4 9 10 infections infection NNS cord-009561-pg4jmvw4 9 11 may may MD cord-009561-pg4jmvw4 9 12 precipitate precipitate VB cord-009561-pg4jmvw4 9 13 exacerbations exacerbation NNS cord-009561-pg4jmvw4 9 14 of of IN cord-009561-pg4jmvw4 9 15 disease disease NN cord-009561-pg4jmvw4 9 16 , , , cord-009561-pg4jmvw4 9 17 ( ( -LRB- cord-009561-pg4jmvw4 9 18 2 2 LS cord-009561-pg4jmvw4 9 19 ) ) -RRB- cord-009561-pg4jmvw4 9 20 experimental experimental JJ cord-009561-pg4jmvw4 9 21 infections infection NNS cord-009561-pg4jmvw4 9 22 in in IN cord-009561-pg4jmvw4 9 23 animals animal NNS cord-009561-pg4jmvw4 9 24 and and CC cord-009561-pg4jmvw4 9 25 natural natural JJ cord-009561-pg4jmvw4 9 26 infections infection NNS cord-009561-pg4jmvw4 9 27 in in IN cord-009561-pg4jmvw4 9 28 humans human NNS cord-009561-pg4jmvw4 9 29 can can MD cord-009561-pg4jmvw4 9 30 cause cause VB cord-009561-pg4jmvw4 9 31 diseases disease NNS cord-009561-pg4jmvw4 9 32 with with IN cord-009561-pg4jmvw4 9 33 long long JJ cord-009561-pg4jmvw4 9 34 incubation incubation NN cord-009561-pg4jmvw4 9 35 periods period NNS cord-009561-pg4jmvw4 9 36 , , , cord-009561-pg4jmvw4 9 37 remitting remit VBG cord-009561-pg4jmvw4 9 38 and and CC cord-009561-pg4jmvw4 9 39 relapsing relapse VBG cord-009561-pg4jmvw4 9 40 courses course NNS cord-009561-pg4jmvw4 9 41 , , , cord-009561-pg4jmvw4 9 42 and and CC cord-009561-pg4jmvw4 9 43 demyelination demyelination NN cord-009561-pg4jmvw4 9 44 , , , cord-009561-pg4jmvw4 9 45 and and CC cord-009561-pg4jmvw4 9 46 ( ( -LRB- cord-009561-pg4jmvw4 9 47 3 3 LS cord-009561-pg4jmvw4 9 48 ) ) -RRB- cord-009561-pg4jmvw4 9 49 patients patient NNS cord-009561-pg4jmvw4 9 50 with with IN cord-009561-pg4jmvw4 9 51 multiple multiple JJ cord-009561-pg4jmvw4 9 52 sclerosis sclerosis NN cord-009561-pg4jmvw4 9 53 have have VBP cord-009561-pg4jmvw4 9 54 abnormal abnormal JJ cord-009561-pg4jmvw4 9 55 immune immune JJ cord-009561-pg4jmvw4 9 56 responses response NNS cord-009561-pg4jmvw4 9 57 to to IN cord-009561-pg4jmvw4 9 58 viruses virus NNS cord-009561-pg4jmvw4 9 59 . . . cord-009561-pg4jmvw4 10 1 The the DT cord-009561-pg4jmvw4 10 2 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 10 3 of of IN cord-009561-pg4jmvw4 10 4 three three CD cord-009561-pg4jmvw4 10 5 human human JJ cord-009561-pg4jmvw4 10 6 demyelinating demyelinate VBG cord-009561-pg4jmvw4 10 7 diseases disease NNS cord-009561-pg4jmvw4 10 8 of of IN cord-009561-pg4jmvw4 10 9 known know VBN cord-009561-pg4jmvw4 10 10 viral viral JJ cord-009561-pg4jmvw4 10 11 etiology etiology NN cord-009561-pg4jmvw4 10 12 is be VBZ cord-009561-pg4jmvw4 10 13 discussed discuss VBN cord-009561-pg4jmvw4 10 14 . . . cord-009561-pg4jmvw4 11 1 In in IN cord-009561-pg4jmvw4 11 2 progressive progressive JJ cord-009561-pg4jmvw4 11 3 multifocal multifocal JJ cord-009561-pg4jmvw4 11 4 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 11 5 , , , cord-009561-pg4jmvw4 11 6 a a DT cord-009561-pg4jmvw4 11 7 papovavirus papovavirus NN cord-009561-pg4jmvw4 11 8 selectively selectively RB cord-009561-pg4jmvw4 11 9 infects infect VBZ cord-009561-pg4jmvw4 11 10 oligodendrocytes oligodendrocyte NNS cord-009561-pg4jmvw4 11 11 and and CC cord-009561-pg4jmvw4 11 12 causes cause VBZ cord-009561-pg4jmvw4 11 13 focal focal JJ cord-009561-pg4jmvw4 11 14 areas area NNS cord-009561-pg4jmvw4 11 15 of of IN cord-009561-pg4jmvw4 11 16 demyelination demyelination NN cord-009561-pg4jmvw4 11 17 . . . cord-009561-pg4jmvw4 12 1 In in IN cord-009561-pg4jmvw4 12 2 postmeasles postmeasles NNP cord-009561-pg4jmvw4 12 3 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 12 4 , , , cord-009561-pg4jmvw4 12 5 the the DT cord-009561-pg4jmvw4 12 6 virus virus NN cord-009561-pg4jmvw4 12 7 is be VBZ cord-009561-pg4jmvw4 12 8 lymphotrophic lymphotrophic JJ cord-009561-pg4jmvw4 12 9 and and CC cord-009561-pg4jmvw4 12 10 disrupts disrupt VBZ cord-009561-pg4jmvw4 12 11 immune immune JJ cord-009561-pg4jmvw4 12 12 regulation regulation NN cord-009561-pg4jmvw4 12 13 that that WDT cord-009561-pg4jmvw4 12 14 can can MD cord-009561-pg4jmvw4 12 15 result result VB cord-009561-pg4jmvw4 12 16 in in IN cord-009561-pg4jmvw4 12 17 an an DT cord-009561-pg4jmvw4 12 18 autoimmune autoimmune JJ cord-009561-pg4jmvw4 12 19 perivenular perivenular JJ cord-009561-pg4jmvw4 12 20 demyelinating demyelinate VBG cord-009561-pg4jmvw4 12 21 illness illness NN cord-009561-pg4jmvw4 12 22 without without IN cord-009561-pg4jmvw4 12 23 evidence evidence NN cord-009561-pg4jmvw4 12 24 of of IN cord-009561-pg4jmvw4 12 25 infection infection NN cord-009561-pg4jmvw4 12 26 of of IN cord-009561-pg4jmvw4 12 27 the the DT cord-009561-pg4jmvw4 12 28 central central JJ cord-009561-pg4jmvw4 12 29 nervous nervous JJ cord-009561-pg4jmvw4 12 30 system system NN cord-009561-pg4jmvw4 12 31 . . . cord-009561-pg4jmvw4 13 1 In in IN cord-009561-pg4jmvw4 13 2 human human JJ cord-009561-pg4jmvw4 13 3 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 13 4 virus‐encephalopathy virus‐encephalopathy NN cord-009561-pg4jmvw4 13 5 and and CC cord-009561-pg4jmvw4 13 6 myelopathy myelopathy NN cord-009561-pg4jmvw4 13 7 virus virus NN cord-009561-pg4jmvw4 13 8 is be VBZ cord-009561-pg4jmvw4 13 9 present present JJ cord-009561-pg4jmvw4 13 10 in in IN cord-009561-pg4jmvw4 13 11 macrophages macrophage NNS cord-009561-pg4jmvw4 13 12 and and CC cord-009561-pg4jmvw4 13 13 microglia microglia NNS cord-009561-pg4jmvw4 13 14 and and CC cord-009561-pg4jmvw4 13 15 the the DT cord-009561-pg4jmvw4 13 16 myelin myelin NN cord-009561-pg4jmvw4 13 17 abnormalities abnormality NNS cord-009561-pg4jmvw4 13 18 apparently apparently RB cord-009561-pg4jmvw4 13 19 are be VBP cord-009561-pg4jmvw4 13 20 caused cause VBN cord-009561-pg4jmvw4 13 21 by by IN cord-009561-pg4jmvw4 13 22 soluble soluble JJ cord-009561-pg4jmvw4 13 23 factors factor NNS cord-009561-pg4jmvw4 13 24 such such JJ cord-009561-pg4jmvw4 13 25 as as IN cord-009561-pg4jmvw4 13 26 viral viral JJ cord-009561-pg4jmvw4 13 27 proteins protein NNS cord-009561-pg4jmvw4 13 28 , , , cord-009561-pg4jmvw4 13 29 cytokines cytokine NNS cord-009561-pg4jmvw4 13 30 , , , cord-009561-pg4jmvw4 13 31 or or CC cord-009561-pg4jmvw4 13 32 neurotoxins neurotoxin NNS cord-009561-pg4jmvw4 13 33 . . . cord-009561-pg4jmvw4 14 1 These these DT cord-009561-pg4jmvw4 14 2 findings finding NNS cord-009561-pg4jmvw4 14 3 may may MD cord-009561-pg4jmvw4 14 4 have have VB cord-009561-pg4jmvw4 14 5 implications implication NNS cord-009561-pg4jmvw4 14 6 on on IN cord-009561-pg4jmvw4 14 7 how how WRB cord-009561-pg4jmvw4 14 8 , , , cord-009561-pg4jmvw4 14 9 when when WRB cord-009561-pg4jmvw4 14 10 , , , cord-009561-pg4jmvw4 14 11 and and CC cord-009561-pg4jmvw4 14 12 where where WRB cord-009561-pg4jmvw4 14 13 to to TO cord-009561-pg4jmvw4 14 14 seek seek VB cord-009561-pg4jmvw4 14 15 viruses virus NNS cord-009561-pg4jmvw4 14 16 in in IN cord-009561-pg4jmvw4 14 17 multiple multiple JJ cord-009561-pg4jmvw4 14 18 sclerosis sclerosis NN cord-009561-pg4jmvw4 14 19 . . . cord-009561-pg4jmvw4 15 1 In in IN cord-009561-pg4jmvw4 15 2 1868 1868 CD cord-009561-pg4jmvw4 15 3 Jean Jean NNP cord-009561-pg4jmvw4 15 4 Martin Martin NNP cord-009561-pg4jmvw4 15 5 Charcot Charcot NNP cord-009561-pg4jmvw4 15 6 described describe VBD cord-009561-pg4jmvw4 15 7 the the DT cord-009561-pg4jmvw4 15 8 clinical clinical JJ cord-009561-pg4jmvw4 15 9 features feature NNS cord-009561-pg4jmvw4 15 10 of of IN cord-009561-pg4jmvw4 15 11 the the DT cord-009561-pg4jmvw4 15 12 first first JJ cord-009561-pg4jmvw4 15 13 human human JJ cord-009561-pg4jmvw4 15 14 demyelinating demyelinating NN cord-009561-pg4jmvw4 15 15 disease disease NN cord-009561-pg4jmvw4 15 16 , , , cord-009561-pg4jmvw4 15 17 multiple multiple JJ cord-009561-pg4jmvw4 15 18 sclerosis sclerosis NN cord-009561-pg4jmvw4 15 19 , , , cord-009561-pg4jmvw4 15 20 and and CC cord-009561-pg4jmvw4 15 21 postulated postulate VBD cord-009561-pg4jmvw4 15 22 that that IN cord-009561-pg4jmvw4 15 23 the the DT cord-009561-pg4jmvw4 15 24 disease disease NN cord-009561-pg4jmvw4 15 25 resulted result VBD cord-009561-pg4jmvw4 15 26 from from IN cord-009561-pg4jmvw4 15 27 exposure exposure NN cord-009561-pg4jmvw4 15 28 to to IN cord-009561-pg4jmvw4 15 29 dampness dampness NN cord-009561-pg4jmvw4 15 30 or or CC cord-009561-pg4jmvw4 15 31 from from IN cord-009561-pg4jmvw4 15 32 injuries injury NNS cord-009561-pg4jmvw4 15 33 or or CC cord-009561-pg4jmvw4 15 34 emotional emotional JJ cord-009561-pg4jmvw4 15 35 stress stress NN cord-009561-pg4jmvw4 15 36 . . . cord-009561-pg4jmvw4 16 1 Over over IN cord-009561-pg4jmvw4 16 2 the the DT cord-009561-pg4jmvw4 16 3 next next JJ cord-009561-pg4jmvw4 16 4 two two CD cord-009561-pg4jmvw4 16 5 decades decade NNS cord-009561-pg4jmvw4 16 6 Koch Koch NNP cord-009561-pg4jmvw4 16 7 and and CC cord-009561-pg4jmvw4 16 8 Pasteur Pasteur NNP cord-009561-pg4jmvw4 16 9 blazed blaze VBD cord-009561-pg4jmvw4 16 10 the the DT cord-009561-pg4jmvw4 16 11 new new JJ cord-009561-pg4jmvw4 16 12 era era NN cord-009561-pg4jmvw4 16 13 of of IN cord-009561-pg4jmvw4 16 14 microbiology microbiology NN cord-009561-pg4jmvw4 16 15 ; ; : cord-009561-pg4jmvw4 16 16 therefore therefore RB cord-009561-pg4jmvw4 16 17 , , , cord-009561-pg4jmvw4 16 18 it -PRON- PRP cord-009561-pg4jmvw4 16 19 was be VBD cord-009561-pg4jmvw4 16 20 a a DT cord-009561-pg4jmvw4 16 21 natural natural JJ cord-009561-pg4jmvw4 16 22 sign sign NN cord-009561-pg4jmvw4 16 23 of of IN cord-009561-pg4jmvw4 16 24 the the DT cord-009561-pg4jmvw4 16 25 times time NNS cord-009561-pg4jmvw4 16 26 that that IN cord-009561-pg4jmvw4 16 27 in in IN cord-009561-pg4jmvw4 16 28 1884 1884 CD cord-009561-pg4jmvw4 16 29 Pierre Pierre NNP cord-009561-pg4jmvw4 16 30 Marie Marie NNP cord-009561-pg4jmvw4 16 31 , , , cord-009561-pg4jmvw4 16 32 one one CD cord-009561-pg4jmvw4 16 33 of of IN cord-009561-pg4jmvw4 16 34 Charcot Charcot NNP cord-009561-pg4jmvw4 16 35 's 's POS cord-009561-pg4jmvw4 16 36 students student NNS cord-009561-pg4jmvw4 16 37 and and CC cord-009561-pg4jmvw4 16 38 a a DT cord-009561-pg4jmvw4 16 39 successor successor NN cord-009561-pg4jmvw4 16 40 to to IN cord-009561-pg4jmvw4 16 41 his -PRON- PRP$ cord-009561-pg4jmvw4 16 42 chair chair NN cord-009561-pg4jmvw4 16 43 in in IN cord-009561-pg4jmvw4 16 44 neurology neurology NN cord-009561-pg4jmvw4 16 45 at at IN cord-009561-pg4jmvw4 16 46 the the DT cord-009561-pg4jmvw4 16 47 University University NNP cord-009561-pg4jmvw4 16 48 of of IN cord-009561-pg4jmvw4 16 49 Paris Paris NNP cord-009561-pg4jmvw4 16 50 , , , cord-009561-pg4jmvw4 16 51 postulated postulate VBD cord-009561-pg4jmvw4 16 52 an an DT cord-009561-pg4jmvw4 16 53 infectious infectious JJ cord-009561-pg4jmvw4 16 54 etiology etiology NN cord-009561-pg4jmvw4 16 55 for for IN cord-009561-pg4jmvw4 16 56 multiple multiple JJ cord-009561-pg4jmvw4 16 57 sclerosis sclerosis NN cord-009561-pg4jmvw4 16 58 . . . cord-009561-pg4jmvw4 17 1 Because because IN cord-009561-pg4jmvw4 17 2 a a DT cord-009561-pg4jmvw4 17 3 rabies rabies NN cord-009561-pg4jmvw4 17 4 vaccine vaccine NN cord-009561-pg4jmvw4 17 5 had have VBD cord-009561-pg4jmvw4 17 6 just just RB cord-009561-pg4jmvw4 17 7 been be VBN cord-009561-pg4jmvw4 17 8 introduced introduce VBN cord-009561-pg4jmvw4 17 9 by by IN cord-009561-pg4jmvw4 17 10 Pasteur Pasteur NNP cord-009561-pg4jmvw4 17 11 , , , cord-009561-pg4jmvw4 17 12 Marie Marie NNP cord-009561-pg4jmvw4 17 13 believed believe VBD cord-009561-pg4jmvw4 17 14 a a DT cord-009561-pg4jmvw4 17 15 vaccine vaccine NN cord-009561-pg4jmvw4 17 16 for for IN cord-009561-pg4jmvw4 17 17 multiple multiple JJ cord-009561-pg4jmvw4 17 18 sclerosis sclerosis NN cord-009561-pg4jmvw4 17 19 would would MD cord-009561-pg4jmvw4 17 20 soon soon RB cord-009561-pg4jmvw4 17 21 be be VB cord-009561-pg4jmvw4 17 22 produced produce VBN cord-009561-pg4jmvw4 17 23 111 111 CD cord-009561-pg4jmvw4 17 24 . . . cord-009561-pg4jmvw4 18 1 Speculation speculation NN cord-009561-pg4jmvw4 18 2 of of IN cord-009561-pg4jmvw4 18 3 a a DT cord-009561-pg4jmvw4 18 4 viral viral JJ cord-009561-pg4jmvw4 18 5 etiology etiology NN cord-009561-pg4jmvw4 18 6 of of IN cord-009561-pg4jmvw4 18 7 multiple multiple JJ cord-009561-pg4jmvw4 18 8 sclerosis sclerosis NN cord-009561-pg4jmvw4 18 9 has have VBZ cord-009561-pg4jmvw4 18 10 recurred recur VBN cord-009561-pg4jmvw4 18 11 during during IN cord-009561-pg4jmvw4 18 12 the the DT cord-009561-pg4jmvw4 18 13 past past JJ cord-009561-pg4jmvw4 18 14 century century NN cord-009561-pg4jmvw4 18 15 . . . cord-009561-pg4jmvw4 19 1 This this DT cord-009561-pg4jmvw4 19 2 speculation speculation NN cord-009561-pg4jmvw4 19 3 has have VBZ cord-009561-pg4jmvw4 19 4 been be VBN cord-009561-pg4jmvw4 19 5 given give VBN cord-009561-pg4jmvw4 19 6 credence credence NN cord-009561-pg4jmvw4 19 7 by by IN cord-009561-pg4jmvw4 19 8 three three CD cord-009561-pg4jmvw4 19 9 areas area NNS cord-009561-pg4jmvw4 19 10 of of IN cord-009561-pg4jmvw4 19 11 investigation investigation NN cord-009561-pg4jmvw4 19 12 . . . cord-009561-pg4jmvw4 20 1 First first RB cord-009561-pg4jmvw4 20 2 , , , cord-009561-pg4jmvw4 20 3 epidemiologic epidemiologic JJ cord-009561-pg4jmvw4 20 4 studies study NNS cord-009561-pg4jmvw4 20 5 have have VBP cord-009561-pg4jmvw4 20 6 indicated indicate VBN cord-009561-pg4jmvw4 20 7 a a DT cord-009561-pg4jmvw4 20 8 childhood childhood NN cord-009561-pg4jmvw4 20 9 exposure exposure NN cord-009561-pg4jmvw4 20 10 factor factor NN cord-009561-pg4jmvw4 20 11 ( ( -LRB- cord-009561-pg4jmvw4 20 12 possibly possibly RB cord-009561-pg4jmvw4 20 13 an an DT cord-009561-pg4jmvw4 20 14 infectious infectious JJ cord-009561-pg4jmvw4 20 15 agent agent NN cord-009561-pg4jmvw4 20 16 ) ) -RRB- cord-009561-pg4jmvw4 20 17 in in IN cord-009561-pg4jmvw4 20 18 the the DT cord-009561-pg4jmvw4 20 19 genesis genesis NN cord-009561-pg4jmvw4 20 20 of of IN cord-009561-pg4jmvw4 20 21 multiple multiple JJ cord-009561-pg4jmvw4 20 22 sclerosis sclerosis NNP cord-009561-pg4jmvw4 20 23 12 12 CD cord-009561-pg4jmvw4 20 24 , , , cord-009561-pg4jmvw4 20 25 31 31 CD cord-009561-pg4jmvw4 20 26 and and CC cord-009561-pg4jmvw4 20 27 also also RB cord-009561-pg4jmvw4 20 28 have have VBP cord-009561-pg4jmvw4 20 29 suggested suggest VBN cord-009561-pg4jmvw4 20 30 that that IN cord-009561-pg4jmvw4 20 31 infections infection NNS cord-009561-pg4jmvw4 20 32 may may MD cord-009561-pg4jmvw4 20 33 precipitate precipitate VB cord-009561-pg4jmvw4 20 34 acute acute JJ cord-009561-pg4jmvw4 20 35 exacerbation exacerbation NN cord-009561-pg4jmvw4 20 36 in in IN cord-009561-pg4jmvw4 20 37 established establish VBN cord-009561-pg4jmvw4 20 38 disease disease NN cord-009561-pg4jmvw4 20 39 14 14 CD cord-009561-pg4jmvw4 20 40 , , , cord-009561-pg4jmvw4 20 41 51 51 CD cord-009561-pg4jmvw4 20 42 . . . cord-009561-pg4jmvw4 21 1 Second second RB cord-009561-pg4jmvw4 21 2 , , , cord-009561-pg4jmvw4 21 3 studies study NNS cord-009561-pg4jmvw4 21 4 in in IN cord-009561-pg4jmvw4 21 5 a a DT cord-009561-pg4jmvw4 21 6 wide wide JJ cord-009561-pg4jmvw4 21 7 variety variety NN cord-009561-pg4jmvw4 21 8 of of IN cord-009561-pg4jmvw4 21 9 animal animal NN cord-009561-pg4jmvw4 21 10 models model NNS cord-009561-pg4jmvw4 21 11 ( ( -LRB- cord-009561-pg4jmvw4 21 12 Table table NN cord-009561-pg4jmvw4 21 13 1 1 CD cord-009561-pg4jmvw4 21 14 ) ) -RRB- cord-009561-pg4jmvw4 21 15 and and CC cord-009561-pg4jmvw4 21 16 human human JJ cord-009561-pg4jmvw4 21 17 diseases disease NNS cord-009561-pg4jmvw4 21 18 have have VBP cord-009561-pg4jmvw4 21 19 shown show VBN cord-009561-pg4jmvw4 21 20 that that IN cord-009561-pg4jmvw4 21 21 viruses virus NNS cord-009561-pg4jmvw4 21 22 can can MD cord-009561-pg4jmvw4 21 23 cause cause VB cord-009561-pg4jmvw4 21 24 diseases disease NNS cord-009561-pg4jmvw4 21 25 with with IN cord-009561-pg4jmvw4 21 26 prolonged prolong VBN cord-009561-pg4jmvw4 21 27 incubation incubation NN cord-009561-pg4jmvw4 21 28 periods period NNS cord-009561-pg4jmvw4 21 29 , , , cord-009561-pg4jmvw4 21 30 with with IN cord-009561-pg4jmvw4 21 31 remitting remit VBG cord-009561-pg4jmvw4 21 32 and and CC cord-009561-pg4jmvw4 21 33 relapsing relapse VBG cord-009561-pg4jmvw4 21 34 courses course NNS cord-009561-pg4jmvw4 21 35 , , , cord-009561-pg4jmvw4 21 36 and and CC cord-009561-pg4jmvw4 21 37 with with IN cord-009561-pg4jmvw4 21 38 myelin myelin JJ cord-009561-pg4jmvw4 21 39 destruction destruction NN cord-009561-pg4jmvw4 21 40 mediated mediate VBN cord-009561-pg4jmvw4 21 41 by by IN cord-009561-pg4jmvw4 21 42 a a DT cord-009561-pg4jmvw4 21 43 variety variety NN cord-009561-pg4jmvw4 21 44 of of IN cord-009561-pg4jmvw4 21 45 mechanisms mechanism NNS cord-009561-pg4jmvw4 21 46 . . . cord-009561-pg4jmvw4 22 1 Thud thud NN cord-009561-pg4jmvw4 22 2 , , , cord-009561-pg4jmvw4 22 3 studies study NNS cord-009561-pg4jmvw4 22 4 of of IN cord-009561-pg4jmvw4 22 5 patients patient NNS cord-009561-pg4jmvw4 22 6 with with IN cord-009561-pg4jmvw4 22 7 multiple multiple JJ cord-009561-pg4jmvw4 22 8 sclerosis sclerosis NN cord-009561-pg4jmvw4 22 9 consistently consistently RB cord-009561-pg4jmvw4 22 10 have have VBP cord-009561-pg4jmvw4 22 11 shown show VBN cord-009561-pg4jmvw4 22 12 higher high JJR cord-009561-pg4jmvw4 22 13 levels level NNS cord-009561-pg4jmvw4 22 14 of of IN cord-009561-pg4jmvw4 22 15 antibody antibody NN cord-009561-pg4jmvw4 22 16 against against IN cord-009561-pg4jmvw4 22 17 measles measles NNP cord-009561-pg4jmvw4 22 18 virus virus NN cord-009561-pg4jmvw4 22 19 in in IN cord-009561-pg4jmvw4 22 20 serum serum NN cord-009561-pg4jmvw4 22 21 and and CC cord-009561-pg4jmvw4 22 22 cerebrospinal cerebrospinal NN cord-009561-pg4jmvw4 22 23 fluid fluid NN cord-009561-pg4jmvw4 22 24 ( ( -LRB- cord-009561-pg4jmvw4 22 25 CSF CSF NNP cord-009561-pg4jmvw4 22 26 ) ) -RRB- cord-009561-pg4jmvw4 22 27 than than IN cord-009561-pg4jmvw4 22 28 in in IN cord-009561-pg4jmvw4 22 29 controls control NNS cord-009561-pg4jmvw4 22 30 and and CC cord-009561-pg4jmvw4 22 31 in in IN cord-009561-pg4jmvw4 22 32 some some DT cord-009561-pg4jmvw4 22 33 studies study NNS cord-009561-pg4jmvw4 22 34 antibodies antibody NNS cord-009561-pg4jmvw4 22 35 have have VBP cord-009561-pg4jmvw4 22 36 been be VBN cord-009561-pg4jmvw4 22 37 elevated elevate VBN cord-009561-pg4jmvw4 22 38 to to IN cord-009561-pg4jmvw4 22 39 other other JJ cord-009561-pg4jmvw4 22 40 viral viral JJ cord-009561-pg4jmvw4 22 41 agents agent NNS cord-009561-pg4jmvw4 22 42 as as RB cord-009561-pg4jmvw4 22 43 well well RB cord-009561-pg4jmvw4 22 44 ( ( -LRB- cord-009561-pg4jmvw4 22 45 Table table NN cord-009561-pg4jmvw4 22 46 2 2 CD cord-009561-pg4jmvw4 22 47 ) ) -RRB- cord-009561-pg4jmvw4 22 48 . . . cord-009561-pg4jmvw4 23 1 Subsequent subsequent JJ cord-009561-pg4jmvw4 23 2 to to IN cord-009561-pg4jmvw4 23 3 the the DT cord-009561-pg4jmvw4 23 4 description description NN cord-009561-pg4jmvw4 23 5 of of IN cord-009561-pg4jmvw4 23 6 multiple multiple JJ cord-009561-pg4jmvw4 23 7 sclerosis sclerosis NN cord-009561-pg4jmvw4 23 8 three three CD cord-009561-pg4jmvw4 23 9 human human JJ cord-009561-pg4jmvw4 23 10 demyelinating demyelinate VBG cord-009561-pg4jmvw4 23 11 diseases disease NNS cord-009561-pg4jmvw4 23 12 have have VBP cord-009561-pg4jmvw4 23 13 been be VBN cord-009561-pg4jmvw4 23 14 defined define VBN cord-009561-pg4jmvw4 23 15 in in IN cord-009561-pg4jmvw4 23 16 which which WDT cord-009561-pg4jmvw4 23 17 viral viral JJ cord-009561-pg4jmvw4 23 18 causes cause NNS cord-009561-pg4jmvw4 23 19 are be VBP cord-009561-pg4jmvw4 23 20 known know VBN cord-009561-pg4jmvw4 23 21 . . . cord-009561-pg4jmvw4 24 1 In in IN cord-009561-pg4jmvw4 24 2 each each DT cord-009561-pg4jmvw4 24 3 , , , cord-009561-pg4jmvw4 24 4 the the DT cord-009561-pg4jmvw4 24 5 causative causative JJ cord-009561-pg4jmvw4 24 6 virus virus NN cord-009561-pg4jmvw4 24 7 is be VBZ cord-009561-pg4jmvw4 24 8 from from IN cord-009561-pg4jmvw4 24 9 a a DT cord-009561-pg4jmvw4 24 10 different different JJ cord-009561-pg4jmvw4 24 11 family family NN cord-009561-pg4jmvw4 24 12 and and CC cord-009561-pg4jmvw4 24 13 in in IN cord-009561-pg4jmvw4 24 14 each each DT cord-009561-pg4jmvw4 24 15 the the DT cord-009561-pg4jmvw4 24 16 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 24 17 of of IN cord-009561-pg4jmvw4 24 18 demyelination demyelination NN cord-009561-pg4jmvw4 24 19 appears appear VBZ cord-009561-pg4jmvw4 24 20 to to TO cord-009561-pg4jmvw4 24 21 be be VB cord-009561-pg4jmvw4 24 22 different different JJ cord-009561-pg4jmvw4 24 23 . . . cord-009561-pg4jmvw4 25 1 Progressive progressive JJ cord-009561-pg4jmvw4 25 2 multifocal multifocal JJ cord-009561-pg4jmvw4 25 3 leukoencephalopathy leukoencephalopathy NN cord-009561-pg4jmvw4 25 4 ( ( -LRB- cord-009561-pg4jmvw4 25 5 PML PML NNP cord-009561-pg4jmvw4 25 6 ) ) -RRB- cord-009561-pg4jmvw4 25 7 was be VBD cord-009561-pg4jmvw4 25 8 originally originally RB cord-009561-pg4jmvw4 25 9 described describe VBN cord-009561-pg4jmvw4 25 10 by by IN cord-009561-pg4jmvw4 25 11 Astrom Astrom NNP cord-009561-pg4jmvw4 25 12 and and CC cord-009561-pg4jmvw4 25 13 collaborators collaborator NNS cord-009561-pg4jmvw4 25 14 121 121 CD cord-009561-pg4jmvw4 25 15 ) ) -RRB- cord-009561-pg4jmvw4 25 16 in in IN cord-009561-pg4jmvw4 25 17 1958 1958 CD cord-009561-pg4jmvw4 25 18 as as IN cord-009561-pg4jmvw4 25 19 a a DT cord-009561-pg4jmvw4 25 20 rare rare JJ cord-009561-pg4jmvw4 25 21 complication complication NN cord-009561-pg4jmvw4 25 22 of of IN cord-009561-pg4jmvw4 25 23 leukemia leukemia NN cord-009561-pg4jmvw4 25 24 and and CC cord-009561-pg4jmvw4 25 25 lymphoma lymphoma NN cord-009561-pg4jmvw4 26 1 It -PRON- PRP cord-009561-pg4jmvw4 26 2 was be VBD cord-009561-pg4jmvw4 26 3 subsequently subsequently RB cord-009561-pg4jmvw4 26 4 seen see VBN cord-009561-pg4jmvw4 26 5 in in IN cord-009561-pg4jmvw4 26 6 a a DT cord-009561-pg4jmvw4 26 7 variety variety NN cord-009561-pg4jmvw4 26 8 of of IN cord-009561-pg4jmvw4 26 9 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 26 10 states state NNS cord-009561-pg4jmvw4 26 11 caused cause VBN cord-009561-pg4jmvw4 26 12 by by IN cord-009561-pg4jmvw4 26 13 other other JJ cord-009561-pg4jmvw4 26 14 diseases disease NNS cord-009561-pg4jmvw4 26 15 and and CC cord-009561-pg4jmvw4 26 16 medical medical JJ cord-009561-pg4jmvw4 26 17 therapy therapy NN cord-009561-pg4jmvw4 26 18 . . . cord-009561-pg4jmvw4 27 1 Over over IN cord-009561-pg4jmvw4 27 2 the the DT cord-009561-pg4jmvw4 27 3 last last JJ cord-009561-pg4jmvw4 27 4 decade decade NN cord-009561-pg4jmvw4 27 5 , , , cord-009561-pg4jmvw4 27 6 the the DT cord-009561-pg4jmvw4 27 7 disease disease NN cord-009561-pg4jmvw4 27 8 has have VBZ cord-009561-pg4jmvw4 27 9 increased increase VBN cord-009561-pg4jmvw4 27 10 greatly greatly RB cord-009561-pg4jmvw4 27 11 in in IN cord-009561-pg4jmvw4 27 12 frequency frequency NN cord-009561-pg4jmvw4 27 13 as as IN cord-009561-pg4jmvw4 27 14 a a DT cord-009561-pg4jmvw4 27 15 complication complication NN cord-009561-pg4jmvw4 27 16 of of IN cord-009561-pg4jmvw4 27 17 the the DT cord-009561-pg4jmvw4 27 18 acquired acquire VBN cord-009561-pg4jmvw4 27 19 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 27 20 syndrome syndrome NN cord-009561-pg4jmvw4 27 21 ( ( -LRB- cord-009561-pg4jmvw4 27 22 AIDS AIDS NNP cord-009561-pg4jmvw4 27 23 ) ) -RRB- cord-009561-pg4jmvw4 27 24 . . . cord-009561-pg4jmvw4 28 1 Clinically clinically RB cord-009561-pg4jmvw4 28 2 , , , cord-009561-pg4jmvw4 28 3 against against IN cord-009561-pg4jmvw4 28 4 the the DT cord-009561-pg4jmvw4 28 5 background background NN cord-009561-pg4jmvw4 28 6 of of IN cord-009561-pg4jmvw4 28 7 immune immune JJ cord-009561-pg4jmvw4 28 8 deficiency deficiency NN cord-009561-pg4jmvw4 28 9 , , , cord-009561-pg4jmvw4 28 10 multifocal multifocal JJ cord-009561-pg4jmvw4 28 11 neurological neurological JJ cord-009561-pg4jmvw4 28 12 signs sign NNS cord-009561-pg4jmvw4 28 13 develop develop VBP cord-009561-pg4jmvw4 28 14 and and CC cord-009561-pg4jmvw4 28 15 follow follow VB cord-009561-pg4jmvw4 28 16 an an DT cord-009561-pg4jmvw4 28 17 ingravescent ingravescent NN cord-009561-pg4jmvw4 28 18 course course NN cord-009561-pg4jmvw4 28 19 usually usually RB cord-009561-pg4jmvw4 28 20 ending end VBG cord-009561-pg4jmvw4 28 21 in in IN cord-009561-pg4jmvw4 28 22 death death NN cord-009561-pg4jmvw4 28 23 in in IN cord-009561-pg4jmvw4 28 24 less less JJR cord-009561-pg4jmvw4 28 25 than than IN cord-009561-pg4jmvw4 28 26 6 6 CD cord-009561-pg4jmvw4 28 27 months month NNS cord-009561-pg4jmvw4 28 28 . . . cord-009561-pg4jmvw4 29 1 Very very RB cord-009561-pg4jmvw4 29 2 rare rare JJ cord-009561-pg4jmvw4 29 3 cases case NNS cord-009561-pg4jmvw4 29 4 have have VBP cord-009561-pg4jmvw4 29 5 stabilized stabilize VBN cord-009561-pg4jmvw4 29 6 or or CC cord-009561-pg4jmvw4 29 7 recovered recover VBN cord-009561-pg4jmvw4 29 8 122,231 122,231 CD cord-009561-pg4jmvw4 29 9 . . . cord-009561-pg4jmvw4 30 1 The the DT cord-009561-pg4jmvw4 30 2 CSF CSF NNP cord-009561-pg4jmvw4 30 3 is be VBZ cord-009561-pg4jmvw4 30 4 usually usually RB cord-009561-pg4jmvw4 30 5 normal normal JJ cord-009561-pg4jmvw4 30 6 . . . cord-009561-pg4jmvw4 31 1 Neuropathology Neuropathology NNP cord-009561-pg4jmvw4 31 2 shows show VBZ cord-009561-pg4jmvw4 31 3 demyelinated demyelinate VBN cord-009561-pg4jmvw4 31 4 foci foci NN cord-009561-pg4jmvw4 31 5 , , , cord-009561-pg4jmvw4 31 6 particularly particularly RB cord-009561-pg4jmvw4 31 7 in in IN cord-009561-pg4jmvw4 31 8 the the DT cord-009561-pg4jmvw4 31 9 subconical subconical NNP cord-009561-pg4jmvw4 31 10 white white JJ cord-009561-pg4jmvw4 31 11 matter matter NN cord-009561-pg4jmvw4 31 12 . . . cord-009561-pg4jmvw4 32 1 Within within IN cord-009561-pg4jmvw4 32 2 these these DT cord-009561-pg4jmvw4 32 3 foci focus NNS cord-009561-pg4jmvw4 32 4 the the DT cord-009561-pg4jmvw4 32 5 oligodendrocytes oligodendrocyte NNS cord-009561-pg4jmvw4 32 6 are be VBP cord-009561-pg4jmvw4 32 7 gone go VBN cord-009561-pg4jmvw4 32 8 and and CC cord-009561-pg4jmvw4 32 9 astrocytes astrocyte NNS cord-009561-pg4jmvw4 32 10 are be VBP cord-009561-pg4jmvw4 32 11 enlarged enlarge VBN cord-009561-pg4jmvw4 32 12 , , , cord-009561-pg4jmvw4 32 13 misshapen misshapen JJ cord-009561-pg4jmvw4 32 14 , , , cord-009561-pg4jmvw4 32 15 and and CC cord-009561-pg4jmvw4 32 16 often often RB cord-009561-pg4jmvw4 32 17 multinucleated multinucleate VBD cord-009561-pg4jmvw4 32 18 . . . cord-009561-pg4jmvw4 33 1 Surrounding surround VBG cord-009561-pg4jmvw4 33 2 the the DT cord-009561-pg4jmvw4 33 3 foci foci NN cord-009561-pg4jmvw4 33 4 many many JJ cord-009561-pg4jmvw4 33 5 of of IN cord-009561-pg4jmvw4 33 6 the the DT cord-009561-pg4jmvw4 33 7 ohgodendroglia ohgodendroglia NNS cord-009561-pg4jmvw4 33 8 are be VBP cord-009561-pg4jmvw4 33 9 enlarged enlarge VBN cord-009561-pg4jmvw4 33 10 and and CC cord-009561-pg4jmvw4 33 11 contain contain VB cord-009561-pg4jmvw4 33 12 intranuclear intranuclear NN cord-009561-pg4jmvw4 33 13 inclusions inclusion NNS cord-009561-pg4jmvw4 33 14 . . . cord-009561-pg4jmvw4 34 1 The the DT cord-009561-pg4jmvw4 34 2 neurons neuron NNS cord-009561-pg4jmvw4 34 3 and and CC cord-009561-pg4jmvw4 34 4 many many JJ cord-009561-pg4jmvw4 34 5 of of IN cord-009561-pg4jmvw4 34 6 their -PRON- PRP$ cord-009561-pg4jmvw4 34 7 axons axon NNS cord-009561-pg4jmvw4 34 8 coursing course VBG cord-009561-pg4jmvw4 34 9 through through IN cord-009561-pg4jmvw4 34 10 the the DT cord-009561-pg4jmvw4 34 11 demyelinated demyelinate VBN cord-009561-pg4jmvw4 34 12 areas area NNS cord-009561-pg4jmvw4 34 13 appear appear VBP cord-009561-pg4jmvw4 34 14 normal normal JJ cord-009561-pg4jmvw4 34 15 . . . cord-009561-pg4jmvw4 35 1 Despite despite IN cord-009561-pg4jmvw4 35 2 the the DT cord-009561-pg4jmvw4 35 3 paucity paucity NN cord-009561-pg4jmvw4 35 4 of of IN cord-009561-pg4jmvw4 35 5 inflammation inflammation NN cord-009561-pg4jmvw4 35 6 , , , cord-009561-pg4jmvw4 35 7 Richardson Richardson NNP cord-009561-pg4jmvw4 35 8 [ [ -LRB- cord-009561-pg4jmvw4 35 9 24 24 CD cord-009561-pg4jmvw4 35 10 } } -RRB- cord-009561-pg4jmvw4 35 11 postulated postulate VBD cord-009561-pg4jmvw4 35 12 that that IN cord-009561-pg4jmvw4 35 13 this this DT cord-009561-pg4jmvw4 35 14 disease disease NN cord-009561-pg4jmvw4 35 15 might may MD cord-009561-pg4jmvw4 35 16 be be VB cord-009561-pg4jmvw4 35 17 a a DT cord-009561-pg4jmvw4 35 18 viral viral JJ cord-009561-pg4jmvw4 35 19 infection infection NN cord-009561-pg4jmvw4 35 20 of of IN cord-009561-pg4jmvw4 35 21 the the DT cord-009561-pg4jmvw4 35 22 brain brain NN cord-009561-pg4jmvw4 35 23 in in IN cord-009561-pg4jmvw4 35 24 an an DT cord-009561-pg4jmvw4 35 25 immunocompromised immunocompromised JJ cord-009561-pg4jmvw4 35 26 host host NN cord-009561-pg4jmvw4 35 27 . . . cord-009561-pg4jmvw4 36 1 In in IN cord-009561-pg4jmvw4 36 2 usually usually RB cord-009561-pg4jmvw4 36 3 causes cause VBZ cord-009561-pg4jmvw4 36 4 infection infection NN cord-009561-pg4jmvw4 36 5 of of IN cord-009561-pg4jmvw4 36 6 the the DT cord-009561-pg4jmvw4 36 7 human human JJ cord-009561-pg4jmvw4 36 8 populations population NNS cord-009561-pg4jmvw4 36 9 during during IN cord-009561-pg4jmvw4 36 10 childhood childhood NN cord-009561-pg4jmvw4 36 11 , , , cord-009561-pg4jmvw4 36 12 and and CC cord-009561-pg4jmvw4 36 13 is be VBZ cord-009561-pg4jmvw4 36 14 not not RB cord-009561-pg4jmvw4 36 15 associated associate VBN cord-009561-pg4jmvw4 36 16 with with IN cord-009561-pg4jmvw4 36 17 disease disease NN cord-009561-pg4jmvw4 36 18 . . . cord-009561-pg4jmvw4 37 1 The the DT cord-009561-pg4jmvw4 37 2 development development NN cord-009561-pg4jmvw4 37 3 of of IN cord-009561-pg4jmvw4 37 4 human human JJ cord-009561-pg4jmvw4 37 5 fetal fetal NN cord-009561-pg4jmvw4 37 6 dial dial NN cord-009561-pg4jmvw4 37 7 cultures culture NNS cord-009561-pg4jmvw4 37 8 was be VBD cord-009561-pg4jmvw4 37 9 necessary necessary JJ cord-009561-pg4jmvw4 37 10 to to TO cord-009561-pg4jmvw4 37 11 make make VB cord-009561-pg4jmvw4 37 12 its -PRON- PRP$ cord-009561-pg4jmvw4 37 13 recovery recovery NN cord-009561-pg4jmvw4 37 14 possible possible JJ cord-009561-pg4jmvw4 37 15 . . . cord-009561-pg4jmvw4 38 1 The the DT cord-009561-pg4jmvw4 38 2 bizarre bizarre JJ cord-009561-pg4jmvw4 38 3 forms form NNS cord-009561-pg4jmvw4 38 4 and and CC cord-009561-pg4jmvw4 38 5 mitoses mitose NNS cord-009561-pg4jmvw4 38 6 in in IN cord-009561-pg4jmvw4 38 7 astrocytes astrocyte NNS cord-009561-pg4jmvw4 38 8 are be VBP cord-009561-pg4jmvw4 38 9 described describe VBN cord-009561-pg4jmvw4 38 10 in in IN cord-009561-pg4jmvw4 38 11 the the DT cord-009561-pg4jmvw4 38 12 original original JJ cord-009561-pg4jmvw4 38 13 study study NN cord-009561-pg4jmvw4 38 14 as as IN cord-009561-pg4jmvw4 38 15 being be VBG cord-009561-pg4jmvw4 38 16 " " `` cord-009561-pg4jmvw4 38 17 ordinarily ordinarily RB cord-009561-pg4jmvw4 38 18 met meet VBN cord-009561-pg4jmvw4 38 19 with with IN cord-009561-pg4jmvw4 38 20 only only RB cord-009561-pg4jmvw4 38 21 in in IN cord-009561-pg4jmvw4 38 22 neoplastic neoplastic JJ cord-009561-pg4jmvw4 38 23 processes process NNS cord-009561-pg4jmvw4 38 24 " " '' cord-009561-pg4jmvw4 38 25 121 121 CD cord-009561-pg4jmvw4 38 26 ) ) -RRB- cord-009561-pg4jmvw4 38 27 . . . cord-009561-pg4jmvw4 39 1 Indeed indeed RB cord-009561-pg4jmvw4 39 2 , , , cord-009561-pg4jmvw4 39 3 many many JJ cord-009561-pg4jmvw4 39 4 of of IN cord-009561-pg4jmvw4 39 5 these these DT cord-009561-pg4jmvw4 39 6 astrocytes astrocyte NNS cord-009561-pg4jmvw4 39 7 contain contain VBP cord-009561-pg4jmvw4 39 8 viral viral JJ cord-009561-pg4jmvw4 39 9 DNA dna NN cord-009561-pg4jmvw4 39 10 and and CC cord-009561-pg4jmvw4 39 11 express express JJ cord-009561-pg4jmvw4 39 12 tumor tumor NN cord-009561-pg4jmvw4 39 13 antigen antigen NN cord-009561-pg4jmvw4 39 14 ( ( -LRB- cord-009561-pg4jmvw4 39 15 T T NNP cord-009561-pg4jmvw4 39 16 antigen antigen NN cord-009561-pg4jmvw4 39 17 ) ) -RRB- cord-009561-pg4jmvw4 39 18 , , , cord-009561-pg4jmvw4 39 19 while while IN cord-009561-pg4jmvw4 39 20 relatively relatively RB cord-009561-pg4jmvw4 39 21 smaller small JJR cord-009561-pg4jmvw4 39 22 numbers number NNS cord-009561-pg4jmvw4 39 23 express express VBP cord-009561-pg4jmvw4 39 24 viral viral JJ cord-009561-pg4jmvw4 39 25 antigen antigen NN cord-009561-pg4jmvw4 39 26 or or CC cord-009561-pg4jmvw4 39 27 contain contain VBP cord-009561-pg4jmvw4 39 28 virions virion NNS cord-009561-pg4jmvw4 39 29 1291 1291 CD cord-009561-pg4jmvw4 39 30 . . . cord-009561-pg4jmvw4 40 1 This this DT cord-009561-pg4jmvw4 40 2 nisms nism NNS cord-009561-pg4jmvw4 40 3 have have VBP cord-009561-pg4jmvw4 40 4 not not RB cord-009561-pg4jmvw4 40 5 proved prove VBN cord-009561-pg4jmvw4 40 6 as as RB cord-009561-pg4jmvw4 40 7 straightforward straightforward JJ cord-009561-pg4jmvw4 40 8 . . . cord-009561-pg4jmvw4 41 1 Postinfectious Postinfectious NNP cord-009561-pg4jmvw4 41 2 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 41 3 ( ( -LRB- cord-009561-pg4jmvw4 41 4 aka aka RB cord-009561-pg4jmvw4 41 5 acute acute JJ cord-009561-pg4jmvw4 41 6 disseminated disseminate VBN cord-009561-pg4jmvw4 41 7 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 41 8 , , , cord-009561-pg4jmvw4 41 9 postexanthematous postexanthematous JJ cord-009561-pg4jmvw4 41 10 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 41 11 , , , cord-009561-pg4jmvw4 41 12 and and CC cord-009561-pg4jmvw4 41 13 perivenular perivenular NNP cord-009561-pg4jmvw4 41 14 leukoencephalitis leukoencephalitis NNP cord-009561-pg4jmvw4 41 15 ) ) -RRB- cord-009561-pg4jmvw4 41 16 is be VBZ cord-009561-pg4jmvw4 41 17 a a DT cord-009561-pg4jmvw4 41 18 perivenular perivenular JJ cord-009561-pg4jmvw4 41 19 demyelinaung demyelinaung NNP cord-009561-pg4jmvw4 41 20 disease disease NN cord-009561-pg4jmvw4 41 21 that that WDT cord-009561-pg4jmvw4 41 22 occurs occur VBZ cord-009561-pg4jmvw4 41 23 as as IN cord-009561-pg4jmvw4 41 24 an an DT cord-009561-pg4jmvw4 41 25 unusual unusual JJ cord-009561-pg4jmvw4 41 26 complication complication NN cord-009561-pg4jmvw4 41 27 of of IN cord-009561-pg4jmvw4 41 28 a a DT cord-009561-pg4jmvw4 41 29 variety variety NN cord-009561-pg4jmvw4 41 30 of of IN cord-009561-pg4jmvw4 41 31 viral viral JJ cord-009561-pg4jmvw4 41 32 infections infection NNS cord-009561-pg4jmvw4 41 33 . . . cord-009561-pg4jmvw4 42 1 It -PRON- PRP cord-009561-pg4jmvw4 42 2 was be VBD cord-009561-pg4jmvw4 42 3 most most RBS cord-009561-pg4jmvw4 42 4 common common JJ cord-009561-pg4jmvw4 42 5 following follow VBG cord-009561-pg4jmvw4 42 6 measles measle NNS cord-009561-pg4jmvw4 42 7 and and CC cord-009561-pg4jmvw4 42 8 vaccination vaccination NN cord-009561-pg4jmvw4 42 9 with with IN cord-009561-pg4jmvw4 42 10 vaccinia vaccinia NN cord-009561-pg4jmvw4 42 11 v v NNP cord-009561-pg4jmvw4 42 12 i i NN cord-009561-pg4jmvw4 42 13 m m NN cord-009561-pg4jmvw4 42 14 131 131 CD cord-009561-pg4jmvw4 42 15 , , , cord-009561-pg4jmvw4 42 16 327 327 CD cord-009561-pg4jmvw4 42 17 . . . cord-009561-pg4jmvw4 43 1 The the DT cord-009561-pg4jmvw4 43 2 clinical clinical JJ cord-009561-pg4jmvw4 43 3 and and CC cord-009561-pg4jmvw4 43 4 pathological pathological JJ cord-009561-pg4jmvw4 43 5 disease disease NN cord-009561-pg4jmvw4 43 6 was be VBD cord-009561-pg4jmvw4 43 7 defined define VBN cord-009561-pg4jmvw4 43 8 in in IN cord-009561-pg4jmvw4 43 9 clinical clinical JJ cord-009561-pg4jmvw4 43 10 - - HYPH cord-009561-pg4jmvw4 43 11 pathological pathological JJ cord-009561-pg4jmvw4 43 12 reports report NNS cord-009561-pg4jmvw4 43 13 in in IN cord-009561-pg4jmvw4 43 14 the the DT cord-009561-pg4jmvw4 43 15 1920s 1920s CD cord-009561-pg4jmvw4 43 16 and and CC cord-009561-pg4jmvw4 43 17 was be VBD cord-009561-pg4jmvw4 43 18 differentiated differentiate VBN cord-009561-pg4jmvw4 43 19 from from IN cord-009561-pg4jmvw4 43 20 typical typical JJ cord-009561-pg4jmvw4 43 21 acute acute JJ cord-009561-pg4jmvw4 43 22 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 43 23 with with IN cord-009561-pg4jmvw4 43 24 cortical cortical JJ cord-009561-pg4jmvw4 43 25 inflammation inflammation NN cord-009561-pg4jmvw4 43 26 and and CC cord-009561-pg4jmvw4 43 27 n n NN cord-009561-pg4jmvw4 43 28 e e NNP cord-009561-pg4jmvw4 43 29 w w NNP cord-009561-pg4jmvw4 43 30 nophagia nophagia NNP cord-009561-pg4jmvw4 43 31 . . . cord-009561-pg4jmvw4 44 1 This this DT cord-009561-pg4jmvw4 44 2 syndrome syndrome NN cord-009561-pg4jmvw4 44 3 characteristically characteristically RB cord-009561-pg4jmvw4 44 4 follows follow VBZ cord-009561-pg4jmvw4 44 5 a a DT cord-009561-pg4jmvw4 44 6 febrile febrile JJ cord-009561-pg4jmvw4 44 7 illness illness NN cord-009561-pg4jmvw4 44 8 and and CC cord-009561-pg4jmvw4 44 9 is be VBZ cord-009561-pg4jmvw4 44 10 characterized characterize VBN cord-009561-pg4jmvw4 44 11 by by IN cord-009561-pg4jmvw4 44 12 perivenular perivenular JJ cord-009561-pg4jmvw4 44 13 demyelination demyelination NN cord-009561-pg4jmvw4 44 14 . . . cord-009561-pg4jmvw4 45 1 Postmeasles Postmeasles NNP cord-009561-pg4jmvw4 45 2 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 45 3 , , , cord-009561-pg4jmvw4 45 4 the the DT cord-009561-pg4jmvw4 45 5 commonest common JJS cord-009561-pg4jmvw4 45 6 form form NN cord-009561-pg4jmvw4 45 7 that that WDT cord-009561-pg4jmvw4 45 8 still still RB cord-009561-pg4jmvw4 45 9 occurs occur VBZ cord-009561-pg4jmvw4 45 10 , , , cord-009561-pg4jmvw4 45 11 will will MD cord-009561-pg4jmvw4 45 12 be be VB cord-009561-pg4jmvw4 45 13 discussed discuss VBN cord-009561-pg4jmvw4 45 14 . . . cord-009561-pg4jmvw4 46 1 Postinfectious Postinfectious NNP cord-009561-pg4jmvw4 46 2 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 46 3 complicates complicate VBZ cord-009561-pg4jmvw4 46 4 clinical clinical JJ cord-009561-pg4jmvw4 46 5 measles measle NNS cord-009561-pg4jmvw4 46 6 in in IN cord-009561-pg4jmvw4 46 7 approximately approximately RB cord-009561-pg4jmvw4 46 8 1 1 CD cord-009561-pg4jmvw4 46 9 per per IN cord-009561-pg4jmvw4 46 10 1,000 1,000 CD cord-009561-pg4jmvw4 46 11 cases case NNS cord-009561-pg4jmvw4 46 12 . . . cord-009561-pg4jmvw4 47 1 It -PRON- PRP cord-009561-pg4jmvw4 47 2 is be VBZ cord-009561-pg4jmvw4 47 3 less less RBR cord-009561-pg4jmvw4 47 4 frequent frequent JJ cord-009561-pg4jmvw4 47 5 in in IN cord-009561-pg4jmvw4 47 6 children child NNS cord-009561-pg4jmvw4 47 7 under under IN cord-009561-pg4jmvw4 47 8 2 2 CD cord-009561-pg4jmvw4 47 9 years year NNS cord-009561-pg4jmvw4 47 10 of of IN cord-009561-pg4jmvw4 47 11 age age NN cord-009561-pg4jmvw4 47 12 . . . cord-009561-pg4jmvw4 48 1 Following follow VBG cord-009561-pg4jmvw4 48 2 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 48 3 measles measle NNS cord-009561-pg4jmvw4 48 4 in in IN cord-009561-pg4jmvw4 48 5 otherwise otherwise RB cord-009561-pg4jmvw4 48 6 healthy healthy JJ cord-009561-pg4jmvw4 48 7 children child NNS cord-009561-pg4jmvw4 48 8 , , , cord-009561-pg4jmvw4 48 9 the the DT cord-009561-pg4jmvw4 48 10 disease disease NN cord-009561-pg4jmvw4 48 11 typically typically RB cord-009561-pg4jmvw4 48 12 comes come VBZ cord-009561-pg4jmvw4 48 13 on on IN cord-009561-pg4jmvw4 48 14 4 4 CD cord-009561-pg4jmvw4 48 15 to to TO cord-009561-pg4jmvw4 48 16 5 5 CD cord-009561-pg4jmvw4 48 17 days day NNS cord-009561-pg4jmvw4 48 18 after after IN cord-009561-pg4jmvw4 48 19 the the DT cord-009561-pg4jmvw4 48 20 rash rash NN cord-009561-pg4jmvw4 48 21 . . . cord-009561-pg4jmvw4 49 1 The the DT cord-009561-pg4jmvw4 49 2 rash rash NN cord-009561-pg4jmvw4 49 3 coincides coincide VBZ cord-009561-pg4jmvw4 49 4 with with IN cord-009561-pg4jmvw4 49 5 the the DT cord-009561-pg4jmvw4 49 6 onset onset NN cord-009561-pg4jmvw4 49 7 of of IN cord-009561-pg4jmvw4 49 8 the the DT cord-009561-pg4jmvw4 49 9 immune immune JJ cord-009561-pg4jmvw4 49 10 response response NN cord-009561-pg4jmvw4 49 11 and and CC cord-009561-pg4jmvw4 49 12 the the DT cord-009561-pg4jmvw4 49 13 clearance clearance NN cord-009561-pg4jmvw4 49 14 of of IN cord-009561-pg4jmvw4 49 15 virus virus NN cord-009561-pg4jmvw4 49 16 . . . cord-009561-pg4jmvw4 50 1 After after IN cord-009561-pg4jmvw4 50 2 the the DT cord-009561-pg4jmvw4 50 3 rash rash NN cord-009561-pg4jmvw4 50 4 abates abate VBZ cord-009561-pg4jmvw4 50 5 and and CC cord-009561-pg4jmvw4 50 6 the the DT cord-009561-pg4jmvw4 50 7 child child NN cord-009561-pg4jmvw4 50 8 is be VBZ cord-009561-pg4jmvw4 50 9 returning return VBG cord-009561-pg4jmvw4 50 10 to to IN cord-009561-pg4jmvw4 50 11 activities activity NNS cord-009561-pg4jmvw4 50 12 outside outside IN cord-009561-pg4jmvw4 50 13 the the DT cord-009561-pg4jmvw4 50 14 house house NN cord-009561-pg4jmvw4 50 15 , , , cord-009561-pg4jmvw4 50 16 there there EX cord-009561-pg4jmvw4 50 17 is be VBZ cord-009561-pg4jmvw4 50 18 a a DT cord-009561-pg4jmvw4 50 19 sudden sudden JJ cord-009561-pg4jmvw4 50 20 recurrence recurrence NN cord-009561-pg4jmvw4 50 21 of of IN cord-009561-pg4jmvw4 50 22 fever fever NN cord-009561-pg4jmvw4 50 23 , , , cord-009561-pg4jmvw4 50 24 decrease decrease NN cord-009561-pg4jmvw4 50 25 in in IN cord-009561-pg4jmvw4 50 26 consciousness consciousness NN cord-009561-pg4jmvw4 50 27 , , , cord-009561-pg4jmvw4 50 28 often often RB cord-009561-pg4jmvw4 50 29 seizures seizure NNS cord-009561-pg4jmvw4 50 30 , , , cord-009561-pg4jmvw4 50 31 and and CC cord-009561-pg4jmvw4 50 32 multifocal multifocal JJ cord-009561-pg4jmvw4 50 33 neurological neurological JJ cord-009561-pg4jmvw4 50 34 signs sign NNS cord-009561-pg4jmvw4 50 35 . . . cord-009561-pg4jmvw4 51 1 The the DT cord-009561-pg4jmvw4 51 2 disease disease NN cord-009561-pg4jmvw4 51 3 has have VBZ cord-009561-pg4jmvw4 51 4 an an DT cord-009561-pg4jmvw4 51 5 abrupt abrupt JJ cord-009561-pg4jmvw4 51 6 onset onset NN cord-009561-pg4jmvw4 51 7 , , , cord-009561-pg4jmvw4 51 8 often often RB cord-009561-pg4jmvw4 51 9 reaching reach VBG cord-009561-pg4jmvw4 51 10 its -PRON- PRP$ cord-009561-pg4jmvw4 51 11 nadir nadir NN cord-009561-pg4jmvw4 51 12 within within IN cord-009561-pg4jmvw4 51 13 the the DT cord-009561-pg4jmvw4 51 14 first first JJ cord-009561-pg4jmvw4 51 15 24 24 CD cord-009561-pg4jmvw4 51 16 hours hour NNS cord-009561-pg4jmvw4 51 17 . . . cord-009561-pg4jmvw4 52 1 Mortality mortality NN cord-009561-pg4jmvw4 52 2 is be VBZ cord-009561-pg4jmvw4 52 3 approximately approximately RB cord-009561-pg4jmvw4 52 4 2096 2096 CD cord-009561-pg4jmvw4 52 5 , , , cord-009561-pg4jmvw4 52 6 and and CC cord-009561-pg4jmvw4 52 7 sequelae sequela NNS cord-009561-pg4jmvw4 52 8 persist persist VBP cord-009561-pg4jmvw4 52 9 in in IN cord-009561-pg4jmvw4 52 10 the the DT cord-009561-pg4jmvw4 52 11 majority majority NN cord-009561-pg4jmvw4 52 12 of of IN cord-009561-pg4jmvw4 52 13 survivors survivor NNS cord-009561-pg4jmvw4 52 14 . . . cord-009561-pg4jmvw4 53 1 The the DT cord-009561-pg4jmvw4 53 2 electroencephalogram electroencephalogram NN cord-009561-pg4jmvw4 53 3 is be VBZ cord-009561-pg4jmvw4 53 4 slow slow JJ cord-009561-pg4jmvw4 53 5 but but CC cord-009561-pg4jmvw4 53 6 nonspecific nonspecific JJ cord-009561-pg4jmvw4 53 7 , , , cord-009561-pg4jmvw4 53 8 and and CC cord-009561-pg4jmvw4 53 9 the the DT cord-009561-pg4jmvw4 53 10 CSF CSF NNP cord-009561-pg4jmvw4 53 11 usually usually RB cord-009561-pg4jmvw4 53 12 shows show VBZ cord-009561-pg4jmvw4 53 13 a a DT cord-009561-pg4jmvw4 53 14 mild mild JJ cord-009561-pg4jmvw4 53 15 elevation elevation NN cord-009561-pg4jmvw4 53 16 of of IN cord-009561-pg4jmvw4 53 17 protein protein NN cord-009561-pg4jmvw4 53 18 and and CC cord-009561-pg4jmvw4 53 19 some some DT cord-009561-pg4jmvw4 53 20 mononuclear mononuclear JJ cord-009561-pg4jmvw4 53 21 cells cell NNS cord-009561-pg4jmvw4 53 22 , , , cord-009561-pg4jmvw4 53 23 but but CC cord-009561-pg4jmvw4 53 24 in in IN cord-009561-pg4jmvw4 53 25 about about RB cord-009561-pg4jmvw4 53 26 one one CD cord-009561-pg4jmvw4 53 27 - - HYPH cord-009561-pg4jmvw4 53 28 third third NN cord-009561-pg4jmvw4 53 29 of of IN cord-009561-pg4jmvw4 53 30 the the DT cord-009561-pg4jmvw4 53 31 patients patient NNS cord-009561-pg4jmvw4 53 32 the the DT cord-009561-pg4jmvw4 53 33 CSF CSF NNP cord-009561-pg4jmvw4 53 34 is be VBZ cord-009561-pg4jmvw4 53 35 entirely entirely RB cord-009561-pg4jmvw4 53 36 normal normal JJ cord-009561-pg4jmvw4 53 37 . . . cord-009561-pg4jmvw4 54 1 Neuropathologic Neuropathologic NNP cord-009561-pg4jmvw4 54 2 examination examination NN cord-009561-pg4jmvw4 54 3 shows show VBZ cord-009561-pg4jmvw4 54 4 diffuse diffuse VBP cord-009561-pg4jmvw4 54 5 perivenular perivenular JJ cord-009561-pg4jmvw4 54 6 infiltration infiltration NN cord-009561-pg4jmvw4 54 7 of of IN cord-009561-pg4jmvw4 54 8 mononuclear mononuclear JJ cord-009561-pg4jmvw4 54 9 cells cell NNS cord-009561-pg4jmvw4 54 10 with with IN cord-009561-pg4jmvw4 54 11 demyelination demyelination NN cord-009561-pg4jmvw4 54 12 . . . cord-009561-pg4jmvw4 55 1 Inflammation inflammation NN cord-009561-pg4jmvw4 55 2 of of IN cord-009561-pg4jmvw4 55 3 the the DT cord-009561-pg4jmvw4 55 4 meninges meninge NNS cord-009561-pg4jmvw4 55 5 is be VBZ cord-009561-pg4jmvw4 55 6 limited limit VBN cord-009561-pg4jmvw4 55 7 or or CC cord-009561-pg4jmvw4 55 8 absent absent JJ cord-009561-pg4jmvw4 55 9 . . . cord-009561-pg4jmvw4 56 1 Histologically histologically RB cord-009561-pg4jmvw4 56 2 the the DT cord-009561-pg4jmvw4 56 3 lesions lesion NNS cord-009561-pg4jmvw4 56 4 resemble resemble VBP cord-009561-pg4jmvw4 56 5 those those DT cord-009561-pg4jmvw4 56 6 that that WDT cord-009561-pg4jmvw4 56 7 were be VBD cord-009561-pg4jmvw4 56 8 subsequently subsequently RB cord-009561-pg4jmvw4 56 9 induced induce VBN cord-009561-pg4jmvw4 56 10 experimentally experimentally RB cord-009561-pg4jmvw4 56 11 by by IN cord-009561-pg4jmvw4 56 12 injection injection NN cord-009561-pg4jmvw4 56 13 of of IN cord-009561-pg4jmvw4 56 14 animals animal NNS cord-009561-pg4jmvw4 56 15 with with IN cord-009561-pg4jmvw4 56 16 myelin myelin NN cord-009561-pg4jmvw4 56 17 proteins protein NNS cord-009561-pg4jmvw4 56 18 with with IN cord-009561-pg4jmvw4 56 19 adjuvant adjuvant NN cord-009561-pg4jmvw4 56 20 , , , cord-009561-pg4jmvw4 56 21 that that RB cord-009561-pg4jmvw4 56 22 is is RB cord-009561-pg4jmvw4 56 23 , , , cord-009561-pg4jmvw4 56 24 experimental experimental JJ cord-009561-pg4jmvw4 56 25 autoimmune autoimmune JJ cord-009561-pg4jmvw4 56 26 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 56 27 . . . cord-009561-pg4jmvw4 57 1 Indeed indeed RB cord-009561-pg4jmvw4 57 2 , , , cord-009561-pg4jmvw4 57 3 the the DT cord-009561-pg4jmvw4 57 4 pattern pattern NN cord-009561-pg4jmvw4 57 5 of of IN cord-009561-pg4jmvw4 57 6 myelin myelin JJ cord-009561-pg4jmvw4 57 7 loss loss NN cord-009561-pg4jmvw4 57 8 in in IN cord-009561-pg4jmvw4 57 9 , , , cord-009561-pg4jmvw4 57 10 the the DT cord-009561-pg4jmvw4 57 11 lesions lesion NNS cord-009561-pg4jmvw4 57 12 is be VBZ cord-009561-pg4jmvw4 57 13 the the DT cord-009561-pg4jmvw4 57 14 same same JJ cord-009561-pg4jmvw4 57 15 as as IN cord-009561-pg4jmvw4 57 16 that that DT cord-009561-pg4jmvw4 57 17 seen see VBN cord-009561-pg4jmvw4 57 18 in in IN cord-009561-pg4jmvw4 57 19 the the DT cord-009561-pg4jmvw4 57 20 experimental experimental JJ cord-009561-pg4jmvw4 57 21 autoimmune autoimmune JJ cord-009561-pg4jmvw4 57 22 disease disease NN cord-009561-pg4jmvw4 57 23 1331 1331 CD cord-009561-pg4jmvw4 57 24 . . . cord-009561-pg4jmvw4 58 1 Because because IN cord-009561-pg4jmvw4 58 2 the the DT cord-009561-pg4jmvw4 58 3 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 58 4 develops develop VBZ cord-009561-pg4jmvw4 58 5 after after IN cord-009561-pg4jmvw4 58 6 the the DT cord-009561-pg4jmvw4 58 7 acute acute JJ cord-009561-pg4jmvw4 58 8 exanthem exanthem NN cord-009561-pg4jmvw4 58 9 and and CC cord-009561-pg4jmvw4 58 10 because because IN cord-009561-pg4jmvw4 58 11 of of IN cord-009561-pg4jmvw4 58 12 the the DT cord-009561-pg4jmvw4 58 13 unusual unusual JJ cord-009561-pg4jmvw4 58 14 pathological pathological JJ cord-009561-pg4jmvw4 58 15 changes change NNS cord-009561-pg4jmvw4 58 16 , , , cord-009561-pg4jmvw4 58 17 it -PRON- PRP cord-009561-pg4jmvw4 58 18 was be VBD cord-009561-pg4jmvw4 58 19 postulated postulate VBN cord-009561-pg4jmvw4 58 20 that that IN cord-009561-pg4jmvw4 58 21 this this DT cord-009561-pg4jmvw4 58 22 was be VBD cord-009561-pg4jmvw4 58 23 not not RB cord-009561-pg4jmvw4 58 24 the the DT cord-009561-pg4jmvw4 58 25 direct direct JJ cord-009561-pg4jmvw4 58 26 virus virus NN cord-009561-pg4jmvw4 58 27 invasion invasion NN cord-009561-pg4jmvw4 58 28 of of IN cord-009561-pg4jmvw4 58 29 the the DT cord-009561-pg4jmvw4 58 30 nervous nervous JJ cord-009561-pg4jmvw4 58 31 system system NN cord-009561-pg4jmvw4 58 32 but but CC cord-009561-pg4jmvw4 58 33 some some DT cord-009561-pg4jmvw4 58 34 toxic toxic JJ cord-009561-pg4jmvw4 58 35 reaction reaction NN cord-009561-pg4jmvw4 58 36 . . . cord-009561-pg4jmvw4 59 1 Subsequent subsequent JJ cord-009561-pg4jmvw4 59 2 to to IN cord-009561-pg4jmvw4 59 3 the the DT cord-009561-pg4jmvw4 59 4 discovery discovery NN cord-009561-pg4jmvw4 59 5 of of IN cord-009561-pg4jmvw4 59 6 experimental experimental JJ cord-009561-pg4jmvw4 59 7 autoimmune autoimmune JJ cord-009561-pg4jmvw4 59 8 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 59 9 in in IN cord-009561-pg4jmvw4 59 10 animals animal NNS cord-009561-pg4jmvw4 59 11 in in IN cord-009561-pg4jmvw4 59 12 the the DT cord-009561-pg4jmvw4 59 13 1930s 1930 NNS cord-009561-pg4jmvw4 59 14 it -PRON- PRP cord-009561-pg4jmvw4 59 15 has have VBZ cord-009561-pg4jmvw4 59 16 been be VBN cord-009561-pg4jmvw4 59 17 assumed assume VBN cord-009561-pg4jmvw4 59 18 that that IN cord-009561-pg4jmvw4 59 19 this this DT cord-009561-pg4jmvw4 59 20 disease disease NN cord-009561-pg4jmvw4 59 21 represented represent VBD cord-009561-pg4jmvw4 59 22 an an DT cord-009561-pg4jmvw4 59 23 autoimmune autoimmune JJ cord-009561-pg4jmvw4 59 24 response response NN cord-009561-pg4jmvw4 59 25 induced induce VBN cord-009561-pg4jmvw4 59 26 by by IN cord-009561-pg4jmvw4 59 27 viral viral JJ cord-009561-pg4jmvw4 59 28 infection infection NN cord-009561-pg4jmvw4 59 29 . . . cord-009561-pg4jmvw4 60 1 Historically historically RB cord-009561-pg4jmvw4 60 2 , , , cord-009561-pg4jmvw4 60 3 approximately approximately RB cord-009561-pg4jmvw4 60 4 one one CD cord-009561-pg4jmvw4 60 5 - - HYPH cord-009561-pg4jmvw4 60 6 third third NN cord-009561-pg4jmvw4 60 7 of of IN cord-009561-pg4jmvw4 60 8 the the DT cord-009561-pg4jmvw4 60 9 cases case NNS cord-009561-pg4jmvw4 60 10 of of IN cord-009561-pg4jmvw4 60 11 encephalitis encephaliti NNS cord-009561-pg4jmvw4 60 12 were be VBD cord-009561-pg4jmvw4 60 13 thought think VBN cord-009561-pg4jmvw4 60 14 to to TO cord-009561-pg4jmvw4 60 15 be be VB cord-009561-pg4jmvw4 60 16 of of IN cord-009561-pg4jmvw4 60 17 this this DT cord-009561-pg4jmvw4 60 18 form form NN cord-009561-pg4jmvw4 60 19 , , , cord-009561-pg4jmvw4 60 20 but but CC cord-009561-pg4jmvw4 60 21 with with IN cord-009561-pg4jmvw4 60 22 the the DT cord-009561-pg4jmvw4 60 23 elimination elimination NN cord-009561-pg4jmvw4 60 24 of of IN cord-009561-pg4jmvw4 60 25 vaccination vaccination NN cord-009561-pg4jmvw4 60 26 to to TO cord-009561-pg4jmvw4 60 27 prevent prevent VB cord-009561-pg4jmvw4 60 28 smallpox smallpox NN cord-009561-pg4jmvw4 60 29 and and CC cord-009561-pg4jmvw4 60 30 the the DT cord-009561-pg4jmvw4 60 31 widespread widespread JJ cord-009561-pg4jmvw4 60 32 use use NN cord-009561-pg4jmvw4 60 33 of of IN cord-009561-pg4jmvw4 60 34 measles measle NNS cord-009561-pg4jmvw4 60 35 vaccine vaccine NN cord-009561-pg4jmvw4 60 36 , , , cord-009561-pg4jmvw4 60 37 few few JJ cord-009561-pg4jmvw4 60 38 cases case NNS cord-009561-pg4jmvw4 60 39 are be VBP cord-009561-pg4jmvw4 60 40 seen see VBN cord-009561-pg4jmvw4 60 41 in in IN cord-009561-pg4jmvw4 60 42 North North NNP cord-009561-pg4jmvw4 60 43 America America NNP cord-009561-pg4jmvw4 60 44 . . . cord-009561-pg4jmvw4 61 1 Cases case NNS cord-009561-pg4jmvw4 61 2 continue continue VBP cord-009561-pg4jmvw4 61 3 in in IN cord-009561-pg4jmvw4 61 4 much much JJ cord-009561-pg4jmvw4 61 5 of of IN cord-009561-pg4jmvw4 61 6 the the DT cord-009561-pg4jmvw4 61 7 world world NN cord-009561-pg4jmvw4 61 8 where where WRB cord-009561-pg4jmvw4 61 9 measles measles NN cord-009561-pg4jmvw4 61 10 continues continue VBZ cord-009561-pg4jmvw4 61 11 partially partially RB cord-009561-pg4jmvw4 61 12 or or CC cord-009561-pg4jmvw4 61 13 totally totally RB cord-009561-pg4jmvw4 61 14 unabated unabated JJ cord-009561-pg4jmvw4 61 15 . . . cord-009561-pg4jmvw4 62 1 Indeed indeed RB cord-009561-pg4jmvw4 62 2 , , , cord-009561-pg4jmvw4 62 3 measles measles NNP cord-009561-pg4jmvw4 62 4 remains remain VBZ cord-009561-pg4jmvw4 62 5 one one CD cord-009561-pg4jmvw4 62 6 of of IN cord-009561-pg4jmvw4 62 7 the the DT cord-009561-pg4jmvw4 62 8 three three CD cord-009561-pg4jmvw4 62 9 major major JJ cord-009561-pg4jmvw4 62 10 killing kill VBG cord-009561-pg4jmvw4 62 11 infectious infectious JJ cord-009561-pg4jmvw4 62 12 diseases disease NNS cord-009561-pg4jmvw4 62 13 worldwide worldwide RB cord-009561-pg4jmvw4 62 14 , , , cord-009561-pg4jmvw4 62 15 causing cause VBG cord-009561-pg4jmvw4 62 16 about about RB cord-009561-pg4jmvw4 62 17 1.5 1.5 CD cord-009561-pg4jmvw4 62 18 million million CD cord-009561-pg4jmvw4 62 19 childhood childhood NN cord-009561-pg4jmvw4 62 20 deaths death NNS cord-009561-pg4jmvw4 62 21 per per IN cord-009561-pg4jmvw4 62 22 year year NN cord-009561-pg4jmvw4 62 23 [ [ -LRB- cord-009561-pg4jmvw4 62 24 341 341 CD cord-009561-pg4jmvw4 62 25 . . . cord-009561-pg4jmvw4 63 1 The the DT cord-009561-pg4jmvw4 63 2 majority majority NN cord-009561-pg4jmvw4 63 3 of of IN cord-009561-pg4jmvw4 63 4 these these DT cord-009561-pg4jmvw4 63 5 deaths death NNS cord-009561-pg4jmvw4 63 6 are be VBP cord-009561-pg4jmvw4 63 7 not not RB cord-009561-pg4jmvw4 63 8 due due JJ cord-009561-pg4jmvw4 63 9 to to IN cord-009561-pg4jmvw4 63 10 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 63 11 , , , cord-009561-pg4jmvw4 63 12 however however RB cord-009561-pg4jmvw4 63 13 , , , cord-009561-pg4jmvw4 63 14 but but CC cord-009561-pg4jmvw4 63 15 to to IN cord-009561-pg4jmvw4 63 16 opportunistic opportunistic JJ cord-009561-pg4jmvw4 63 17 infections infection NNS cord-009561-pg4jmvw4 63 18 that that WDT cord-009561-pg4jmvw4 63 19 complicate complicate VBP cord-009561-pg4jmvw4 63 20 the the DT cord-009561-pg4jmvw4 63 21 decreased decrease VBN cord-009561-pg4jmvw4 63 22 immune immune JJ cord-009561-pg4jmvw4 63 23 responses response NNS cord-009561-pg4jmvw4 63 24 seen see VBN cord-009561-pg4jmvw4 63 25 for for IN cord-009561-pg4jmvw4 63 26 several several JJ cord-009561-pg4jmvw4 63 27 weeks week NNS cord-009561-pg4jmvw4 63 28 following follow VBG cord-009561-pg4jmvw4 63 29 the the DT cord-009561-pg4jmvw4 63 30 measles measle NNS cord-009561-pg4jmvw4 63 31 rash rash JJ cord-009561-pg4jmvw4 63 32 . . . cord-009561-pg4jmvw4 64 1 Thus thus RB cord-009561-pg4jmvw4 64 2 , , , cord-009561-pg4jmvw4 64 3 in in IN cord-009561-pg4jmvw4 64 4 contrast contrast NN cord-009561-pg4jmvw4 64 5 to to IN cord-009561-pg4jmvw4 64 6 PML PML NNP cord-009561-pg4jmvw4 64 7 , , , cord-009561-pg4jmvw4 64 8 measles measles NN cord-009561-pg4jmvw4 64 9 virus virus NN cord-009561-pg4jmvw4 64 10 appears appear VBZ cord-009561-pg4jmvw4 64 11 to to TO cord-009561-pg4jmvw4 64 12 induce induce VB cord-009561-pg4jmvw4 64 13 the the DT cord-009561-pg4jmvw4 64 14 immune immune JJ cord-009561-pg4jmvw4 64 15 deficiency deficiency NN cord-009561-pg4jmvw4 64 16 , , , cord-009561-pg4jmvw4 64 17 and and CC cord-009561-pg4jmvw4 64 18 opportunistic opportunistic JJ cord-009561-pg4jmvw4 64 19 infections infection NNS cord-009561-pg4jmvw4 64 20 lead lead VBP cord-009561-pg4jmvw4 64 21 to to IN cord-009561-pg4jmvw4 64 22 death death NN cord-009561-pg4jmvw4 64 23 . . . cord-009561-pg4jmvw4 65 1 This this DT cord-009561-pg4jmvw4 65 2 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 65 3 was be VBD cord-009561-pg4jmvw4 65 4 first first RB cord-009561-pg4jmvw4 65 5 observed observe VBN cord-009561-pg4jmvw4 65 6 in in IN cord-009561-pg4jmvw4 65 7 1908 1908 CD cord-009561-pg4jmvw4 65 8 by by IN cord-009561-pg4jmvw4 65 9 von von NNP cord-009561-pg4jmvw4 65 10 Pirquet Pirquet NNP cord-009561-pg4jmvw4 65 11 C351 C351 NNP cord-009561-pg4jmvw4 65 12 who who WP cord-009561-pg4jmvw4 65 13 found find VBD cord-009561-pg4jmvw4 65 14 that that IN cord-009561-pg4jmvw4 65 15 children child NNS cord-009561-pg4jmvw4 65 16 converted convert VBD cord-009561-pg4jmvw4 65 17 their -PRON- PRP$ cord-009561-pg4jmvw4 65 18 tuberculin tuberculin NN cord-009561-pg4jmvw4 65 19 reactions reaction NNS cord-009561-pg4jmvw4 65 20 at at IN cord-009561-pg4jmvw4 65 21 the the DT cord-009561-pg4jmvw4 65 22 time time NN cord-009561-pg4jmvw4 65 23 of of IN cord-009561-pg4jmvw4 65 24 rash rash JJ cord-009561-pg4jmvw4 65 25 and and CC cord-009561-pg4jmvw4 65 26 over over IN cord-009561-pg4jmvw4 65 27 subsequent subsequent JJ cord-009561-pg4jmvw4 65 28 weeks week NNS cord-009561-pg4jmvw4 65 29 . . . cord-009561-pg4jmvw4 66 1 Indeed indeed RB cord-009561-pg4jmvw4 66 2 , , , cord-009561-pg4jmvw4 66 3 this this DT cord-009561-pg4jmvw4 66 4 was be VBD cord-009561-pg4jmvw4 66 5 the the DT cord-009561-pg4jmvw4 66 6 first first JJ cord-009561-pg4jmvw4 66 7 documented document VBN cord-009561-pg4jmvw4 66 8 virus virus NN cord-009561-pg4jmvw4 66 9 - - HYPH cord-009561-pg4jmvw4 66 10 induced induce VBN cord-009561-pg4jmvw4 66 11 acquired acquire VBN cord-009561-pg4jmvw4 66 12 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 66 13 syndrome syndrome NN cord-009561-pg4jmvw4 66 14 . . . cord-009561-pg4jmvw4 67 1 A a DT cord-009561-pg4jmvw4 67 2 paradox paradox NN cord-009561-pg4jmvw4 67 3 is be VBZ cord-009561-pg4jmvw4 67 4 evident evident JJ cord-009561-pg4jmvw4 67 5 . . . cord-009561-pg4jmvw4 68 1 The the DT cord-009561-pg4jmvw4 68 2 majority majority NN cord-009561-pg4jmvw4 68 3 of of IN cord-009561-pg4jmvw4 68 4 measles measle NNS cord-009561-pg4jmvw4 68 5 deaths death NNS cord-009561-pg4jmvw4 68 6 are be VBP cord-009561-pg4jmvw4 68 7 due due JJ cord-009561-pg4jmvw4 68 8 to to IN cord-009561-pg4jmvw4 68 9 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 68 10 and and CC cord-009561-pg4jmvw4 68 11 opportunistic opportunistic JJ cord-009561-pg4jmvw4 68 12 infections infection NNS cord-009561-pg4jmvw4 68 13 , , , cord-009561-pg4jmvw4 68 14 whereas whereas IN cord-009561-pg4jmvw4 68 15 in in IN cord-009561-pg4jmvw4 68 16 1 1 CD cord-009561-pg4jmvw4 68 17 per per IN cord-009561-pg4jmvw4 68 18 1,000 1,000 CD cord-009561-pg4jmvw4 68 19 patients patient NNS cord-009561-pg4jmvw4 68 20 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 68 21 develops develop VBZ cord-009561-pg4jmvw4 68 22 , , , cord-009561-pg4jmvw4 68 23 which which WDT cord-009561-pg4jmvw4 68 24 is be VBZ cord-009561-pg4jmvw4 68 25 thought think VBN cord-009561-pg4jmvw4 68 26 to to TO cord-009561-pg4jmvw4 68 27 have have VB cord-009561-pg4jmvw4 68 28 an an DT cord-009561-pg4jmvw4 68 29 autoimmune autoimmune JJ cord-009561-pg4jmvw4 68 30 mechanism mechanism NN cord-009561-pg4jmvw4 68 31 . . . cord-009561-pg4jmvw4 69 1 In in IN cord-009561-pg4jmvw4 69 2 studies study NNS cord-009561-pg4jmvw4 69 3 of of IN cord-009561-pg4jmvw4 69 4 patients patient NNS cord-009561-pg4jmvw4 69 5 with with IN cord-009561-pg4jmvw4 69 6 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 69 7 measles measle NNS cord-009561-pg4jmvw4 69 8 , , , cord-009561-pg4jmvw4 69 9 measles measle NNS cord-009561-pg4jmvw4 69 10 with with IN cord-009561-pg4jmvw4 69 11 pneumonia pneumonia NN cord-009561-pg4jmvw4 69 12 , , , cord-009561-pg4jmvw4 69 13 and and CC cord-009561-pg4jmvw4 69 14 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 69 15 , , , cord-009561-pg4jmvw4 69 16 the the DT cord-009561-pg4jmvw4 69 17 degree degree NN cord-009561-pg4jmvw4 69 18 of of IN cord-009561-pg4jmvw4 69 19 nonresponsiveness nonresponsiveness NN cord-009561-pg4jmvw4 69 20 of of IN cord-009561-pg4jmvw4 69 21 lymphocytes lymphocyte NNS cord-009561-pg4jmvw4 69 22 to to IN cord-009561-pg4jmvw4 69 23 mitogens mitogens NNP cord-009561-pg4jmvw4 69 24 is be VBZ cord-009561-pg4jmvw4 69 25 equal equal JJ cord-009561-pg4jmvw4 69 26 [ [ -LRB- cord-009561-pg4jmvw4 69 27 361 361 CD cord-009561-pg4jmvw4 69 28 . . . cord-009561-pg4jmvw4 70 1 In in IN cord-009561-pg4jmvw4 70 2 all all DT cord-009561-pg4jmvw4 70 3 three three CD cord-009561-pg4jmvw4 70 4 groups group NNS cord-009561-pg4jmvw4 70 5 similar similar JJ cord-009561-pg4jmvw4 70 6 leukopenia leukopenia NN cord-009561-pg4jmvw4 70 7 develops develop VBZ cord-009561-pg4jmvw4 70 8 with with IN cord-009561-pg4jmvw4 70 9 maintenance maintenance NN cord-009561-pg4jmvw4 70 10 of of IN cord-009561-pg4jmvw4 70 11 the the DT cord-009561-pg4jmvw4 70 12 normal normal JJ cord-009561-pg4jmvw4 70 13 T4 T4 NNP cord-009561-pg4jmvw4 70 14 / / SYM cord-009561-pg4jmvw4 70 15 T8 T8 NNP cord-009561-pg4jmvw4 70 16 ratios ratio NNS cord-009561-pg4jmvw4 70 17 137 137 CD cord-009561-pg4jmvw4 70 18 ) ) -RRB- cord-009561-pg4jmvw4 70 19 . . . cord-009561-pg4jmvw4 71 1 All all DT cord-009561-pg4jmvw4 71 2 lose lose VBP cord-009561-pg4jmvw4 71 3 their -PRON- PRP$ cord-009561-pg4jmvw4 71 4 cutaneous cutaneous JJ cord-009561-pg4jmvw4 71 5 tuberculin tuberculin NN cord-009561-pg4jmvw4 71 6 reactions reaction NNS cord-009561-pg4jmvw4 71 7 ; ; : cord-009561-pg4jmvw4 71 8 those those DT cord-009561-pg4jmvw4 71 9 with with IN cord-009561-pg4jmvw4 71 10 infectious infectious JJ cord-009561-pg4jmvw4 71 11 complications complication NNS cord-009561-pg4jmvw4 71 12 remain remain VBP cord-009561-pg4jmvw4 71 13 negative negative JJ cord-009561-pg4jmvw4 71 14 for for IN cord-009561-pg4jmvw4 71 15 a a DT cord-009561-pg4jmvw4 71 16 longer long JJR cord-009561-pg4jmvw4 71 17 period period NN cord-009561-pg4jmvw4 71 18 of of IN cord-009561-pg4jmvw4 71 19 time time NN cord-009561-pg4jmvw4 71 20 1381 1381 CD cord-009561-pg4jmvw4 71 21 . . . cord-009561-pg4jmvw4 72 1 It -PRON- PRP cord-009561-pg4jmvw4 72 2 is be VBZ cord-009561-pg4jmvw4 72 3 clear clear JJ cord-009561-pg4jmvw4 72 4 , , , cord-009561-pg4jmvw4 72 5 however however RB cord-009561-pg4jmvw4 72 6 , , , cord-009561-pg4jmvw4 72 7 that that IN cord-009561-pg4jmvw4 72 8 these these DT cord-009561-pg4jmvw4 72 9 findings finding NNS cord-009561-pg4jmvw4 72 10 do do VBP cord-009561-pg4jmvw4 72 11 not not RB cord-009561-pg4jmvw4 72 12 represent represent VB cord-009561-pg4jmvw4 72 13 simple simple JJ cord-009561-pg4jmvw4 72 14 immunosuppression immunosuppression NN cord-009561-pg4jmvw4 72 15 . . . cord-009561-pg4jmvw4 73 1 There there EX cord-009561-pg4jmvw4 73 2 is be VBZ cord-009561-pg4jmvw4 73 3 activation activation NN cord-009561-pg4jmvw4 73 4 of of IN cord-009561-pg4jmvw4 73 5 lymphoid lymphoid JJ cord-009561-pg4jmvw4 73 6 cells cell NNS cord-009561-pg4jmvw4 73 7 and and CC cord-009561-pg4jmvw4 73 8 spontaneous spontaneous JJ cord-009561-pg4jmvw4 73 9 proliferation proliferation NN cord-009561-pg4jmvw4 73 10 of of IN cord-009561-pg4jmvw4 73 11 lymphocytes lymphocyte NNS cord-009561-pg4jmvw4 73 12 ( ( -LRB- cord-009561-pg4jmvw4 73 13 T4 T4 NNP cord-009561-pg4jmvw4 73 14 , , , cord-009561-pg4jmvw4 73 15 T8 T8 NNP cord-009561-pg4jmvw4 73 16 , , , cord-009561-pg4jmvw4 73 17 and and CC cord-009561-pg4jmvw4 73 18 B b NN cord-009561-pg4jmvw4 73 19 cells cell NNS cord-009561-pg4jmvw4 73 20 ) ) -RRB- cord-009561-pg4jmvw4 74 1 ( ( -LRB- cord-009561-pg4jmvw4 74 2 Table table NN cord-009561-pg4jmvw4 74 3 3 3 CD cord-009561-pg4jmvw4 74 4 ) ) -RRB- cord-009561-pg4jmvw4 74 5 . . . cord-009561-pg4jmvw4 75 1 Rather rather RB cord-009561-pg4jmvw4 75 2 than than IN cord-009561-pg4jmvw4 75 3 immunosuppression immunosuppression NN cord-009561-pg4jmvw4 75 4 , , , cord-009561-pg4jmvw4 75 5 measles measles NN cord-009561-pg4jmvw4 75 6 virus virus NN cord-009561-pg4jmvw4 75 7 produces produce VBZ cord-009561-pg4jmvw4 75 8 an an DT cord-009561-pg4jmvw4 75 9 activation activation NN cord-009561-pg4jmvw4 75 10 of of IN cord-009561-pg4jmvw4 75 11 lymphocytes lymphocyte NNS cord-009561-pg4jmvw4 75 12 and and CC cord-009561-pg4jmvw4 75 13 macrophages macrophage NNS cord-009561-pg4jmvw4 75 14 stimulating stimulate VBG cord-009561-pg4jmvw4 75 15 immunoresponsive immunoresponsive JJ cord-009561-pg4jmvw4 75 16 cells cell NNS cord-009561-pg4jmvw4 75 17 such such JJ cord-009561-pg4jmvw4 75 18 as as IN cord-009561-pg4jmvw4 75 19 those those DT cord-009561-pg4jmvw4 75 20 responsive responsive JJ cord-009561-pg4jmvw4 75 21 to to IN cord-009561-pg4jmvw4 75 22 myelin myelin JJ cord-009561-pg4jmvw4 75 23 basic basic JJ cord-009561-pg4jmvw4 75 24 protein protein NN cord-009561-pg4jmvw4 75 25 ; ; : cord-009561-pg4jmvw4 75 26 proliferation proliferation NN cord-009561-pg4jmvw4 75 27 of of IN cord-009561-pg4jmvw4 75 28 culture culture NN cord-009561-pg4jmvw4 75 29 lymphocytes lymphocyte NNS cord-009561-pg4jmvw4 75 30 in in IN cord-009561-pg4jmvw4 75 31 the the DT cord-009561-pg4jmvw4 75 32 presence presence NN cord-009561-pg4jmvw4 75 33 of of IN cord-009561-pg4jmvw4 75 34 myelin myelin JJ cord-009561-pg4jmvw4 75 35 basic basic JJ cord-009561-pg4jmvw4 75 36 protein protein NN cord-009561-pg4jmvw4 75 37 was be VBD cord-009561-pg4jmvw4 75 38 found find VBN cord-009561-pg4jmvw4 75 39 in in IN cord-009561-pg4jmvw4 75 40 15 15 CD cord-009561-pg4jmvw4 75 41 % % NN cord-009561-pg4jmvw4 75 42 of of IN cord-009561-pg4jmvw4 75 43 the the DT cord-009561-pg4jmvw4 75 44 cases case NNS cord-009561-pg4jmvw4 75 45 of of IN cord-009561-pg4jmvw4 75 46 measles measle NNS cord-009561-pg4jmvw4 75 47 without without IN cord-009561-pg4jmvw4 75 48 neurological neurological JJ cord-009561-pg4jmvw4 75 49 findings finding NNS cord-009561-pg4jmvw4 75 50 and and CC cord-009561-pg4jmvw4 75 51 in in IN cord-009561-pg4jmvw4 75 52 47 47 CD cord-009561-pg4jmvw4 75 53 % % NN cord-009561-pg4jmvw4 75 54 of of IN cord-009561-pg4jmvw4 75 55 those those DT cord-009561-pg4jmvw4 75 56 who who WP cord-009561-pg4jmvw4 75 57 developed develop VBD cord-009561-pg4jmvw4 75 58 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 75 59 1461 1461 CD cord-009561-pg4jmvw4 75 60 . . . cord-009561-pg4jmvw4 76 1 Evidence evidence NN cord-009561-pg4jmvw4 76 2 suggests suggest VBZ cord-009561-pg4jmvw4 76 3 that that IN cord-009561-pg4jmvw4 76 4 measles measle NNS cord-009561-pg4jmvw4 76 5 virus virus NN cord-009561-pg4jmvw4 76 6 may may MD cord-009561-pg4jmvw4 76 7 not not RB cord-009561-pg4jmvw4 76 8 directly directly RB cord-009561-pg4jmvw4 76 9 invade invade VB cord-009561-pg4jmvw4 76 10 the the DT cord-009561-pg4jmvw4 76 11 nervous nervous JJ cord-009561-pg4jmvw4 76 12 system system NN cord-009561-pg4jmvw4 76 13 . . . cord-009561-pg4jmvw4 77 1 Virus virus NN cord-009561-pg4jmvw4 77 2 has have VBZ cord-009561-pg4jmvw4 77 3 only only RB cord-009561-pg4jmvw4 77 4 rarely rarely RB cord-009561-pg4jmvw4 77 5 been be VBN cord-009561-pg4jmvw4 77 6 isolated isolate VBN cord-009561-pg4jmvw4 77 7 from from IN cord-009561-pg4jmvw4 77 8 the the DT cord-009561-pg4jmvw4 77 9 central central JJ cord-009561-pg4jmvw4 77 10 nervous nervous JJ cord-009561-pg4jmvw4 77 11 system system NN cord-009561-pg4jmvw4 77 12 and and CC cord-009561-pg4jmvw4 77 13 our -PRON- PRP$ cord-009561-pg4jmvw4 77 14 isolation isolation NN cord-009561-pg4jmvw4 77 15 attempts attempt NNS cord-009561-pg4jmvw4 77 16 have have VBP cord-009561-pg4jmvw4 77 17 failed fail VBN cord-009561-pg4jmvw4 77 18 . . . cord-009561-pg4jmvw4 78 1 In in IN cord-009561-pg4jmvw4 78 2 studies study NNS cord-009561-pg4jmvw4 78 3 of of IN cord-009561-pg4jmvw4 78 4 CSF CSF NNP cord-009561-pg4jmvw4 78 5 we -PRON- PRP cord-009561-pg4jmvw4 78 6 found find VBD cord-009561-pg4jmvw4 78 7 no no DT cord-009561-pg4jmvw4 78 8 intrathecal intrathecal JJ cord-009561-pg4jmvw4 78 9 synthesis synthesis NN cord-009561-pg4jmvw4 78 10 of of IN cord-009561-pg4jmvw4 78 11 antibody antibody NN cord-009561-pg4jmvw4 78 12 in in IN cord-009561-pg4jmvw4 78 13 posuneasles posuneasle NNS cord-009561-pg4jmvw4 78 14 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 78 15 to to TO cord-009561-pg4jmvw4 78 16 suggest suggest VB cord-009561-pg4jmvw4 78 17 antigenic antigenic JJ cord-009561-pg4jmvw4 78 18 stimulation stimulation NN cord-009561-pg4jmvw4 78 19 Subsequently subsequently RB cord-009561-pg4jmvw4 78 20 , , , cord-009561-pg4jmvw4 78 21 a a DT cord-009561-pg4jmvw4 78 22 variety variety NN cord-009561-pg4jmvw4 78 23 of of IN cord-009561-pg4jmvw4 78 24 diseases disease NNS cord-009561-pg4jmvw4 78 25 of of IN cord-009561-pg4jmvw4 78 26 the the DT cord-009561-pg4jmvw4 78 27 central central JJ cord-009561-pg4jmvw4 78 28 and and CC cord-009561-pg4jmvw4 78 29 peripheral peripheral JJ cord-009561-pg4jmvw4 78 30 nervous nervous JJ cord-009561-pg4jmvw4 78 31 system system NN cord-009561-pg4jmvw4 78 32 and and CC cord-009561-pg4jmvw4 78 33 muscle muscle NN cord-009561-pg4jmvw4 78 34 have have VBP cord-009561-pg4jmvw4 78 35 been be VBN cord-009561-pg4jmvw4 78 36 described describe VBN cord-009561-pg4jmvw4 78 37 as as IN cord-009561-pg4jmvw4 78 38 complications complication NNS cord-009561-pg4jmvw4 78 39 of of IN cord-009561-pg4jmvw4 78 40 HIV HIV NNP cord-009561-pg4jmvw4 78 41 infection infection NN cord-009561-pg4jmvw4 78 42 [ [ -LRB- cord-009561-pg4jmvw4 78 43 58 58 CD cord-009561-pg4jmvw4 78 44 , , , cord-009561-pg4jmvw4 78 45 591 591 CD cord-009561-pg4jmvw4 78 46 . . . cord-009561-pg4jmvw4 79 1 These these DT cord-009561-pg4jmvw4 79 2 occur occur VBP cord-009561-pg4jmvw4 79 3 at at IN cord-009561-pg4jmvw4 79 4 varying vary VBG cord-009561-pg4jmvw4 79 5 times time NNS cord-009561-pg4jmvw4 79 6 . . . cord-009561-pg4jmvw4 80 1 An an DT cord-009561-pg4jmvw4 80 2 acute acute JJ cord-009561-pg4jmvw4 80 3 meningitis meningitis NN cord-009561-pg4jmvw4 80 4 or or CC cord-009561-pg4jmvw4 80 5 an an DT cord-009561-pg4jmvw4 80 6 acute acute JJ cord-009561-pg4jmvw4 80 7 demyelinating demyelinate VBG cord-009561-pg4jmvw4 80 8 polyneuritis polyneuritis NN cord-009561-pg4jmvw4 80 9 may may MD cord-009561-pg4jmvw4 80 10 occur occur VB cord-009561-pg4jmvw4 80 11 at at IN cord-009561-pg4jmvw4 80 12 the the DT cord-009561-pg4jmvw4 80 13 time time NN cord-009561-pg4jmvw4 80 14 of of IN cord-009561-pg4jmvw4 80 15 seroconversion seroconversion NN cord-009561-pg4jmvw4 80 16 ; ; : cord-009561-pg4jmvw4 80 17 HIV HIV NNP cord-009561-pg4jmvw4 80 18 encephalopathy encephalopathy NN cord-009561-pg4jmvw4 80 19 and and CC cord-009561-pg4jmvw4 80 20 myelopathy myelopathy NN cord-009561-pg4jmvw4 80 21 usually usually RB cord-009561-pg4jmvw4 80 22 evolve evolve VBP cord-009561-pg4jmvw4 80 23 years year NNS cord-009561-pg4jmvw4 80 24 later later RB cord-009561-pg4jmvw4 80 25 with with IN cord-009561-pg4jmvw4 80 26 full full RB cord-009561-pg4jmvw4 80 27 - - HYPH cord-009561-pg4jmvw4 80 28 blown blown JJ cord-009561-pg4jmvw4 80 29 AIDS AIDS NNP cord-009561-pg4jmvw4 80 30 . . . cord-009561-pg4jmvw4 81 1 These these DT cord-009561-pg4jmvw4 81 2 different different JJ cord-009561-pg4jmvw4 81 3 syndromes syndrome NNS cord-009561-pg4jmvw4 81 4 show show VBP cord-009561-pg4jmvw4 81 5 very very RB cord-009561-pg4jmvw4 81 6 varied varied JJ cord-009561-pg4jmvw4 81 7 pathological pathological JJ cord-009561-pg4jmvw4 81 8 changes change NNS cord-009561-pg4jmvw4 81 9 , , , cord-009561-pg4jmvw4 81 10 and and CC cord-009561-pg4jmvw4 81 11 in in IN cord-009561-pg4jmvw4 81 12 all all DT cord-009561-pg4jmvw4 81 13 probability probability NN cord-009561-pg4jmvw4 81 14 have have VBP cord-009561-pg4jmvw4 81 15 different different JJ cord-009561-pg4jmvw4 81 16 mechanisms mechanism NNS cord-009561-pg4jmvw4 81 17 of of IN cord-009561-pg4jmvw4 81 18 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 81 19 . . . cord-009561-pg4jmvw4 82 1 In in IN cord-009561-pg4jmvw4 82 2 several several JJ cord-009561-pg4jmvw4 82 3 syndromes syndrome NNS cord-009561-pg4jmvw4 82 4 , , , cord-009561-pg4jmvw4 82 5 demyelination demyelination NN cord-009561-pg4jmvw4 82 6 is be VBZ cord-009561-pg4jmvw4 82 7 a a DT cord-009561-pg4jmvw4 82 8 prominent prominent JJ cord-009561-pg4jmvw4 82 9 feature feature NN cord-009561-pg4jmvw4 82 10 both both CC cord-009561-pg4jmvw4 82 11 early early RB cord-009561-pg4jmvw4 82 12 in in IN cord-009561-pg4jmvw4 82 13 disease disease NN cord-009561-pg4jmvw4 82 14 , , , cord-009561-pg4jmvw4 82 15 when when WRB cord-009561-pg4jmvw4 82 16 a a DT cord-009561-pg4jmvw4 82 17 neuropathy neuropathy NN cord-009561-pg4jmvw4 82 18 resembling resemble VBG cord-009561-pg4jmvw4 82 19 Guillain Guillain NNP cord-009561-pg4jmvw4 82 20 - - HYPH cord-009561-pg4jmvw4 82 21 Bard Bard NNP cord-009561-pg4jmvw4 82 22 syndrome syndrome NN cord-009561-pg4jmvw4 82 23 is be VBZ cord-009561-pg4jmvw4 82 24 usually usually RB cord-009561-pg4jmvw4 82 25 seen see VBN cord-009561-pg4jmvw4 82 26 , , , cord-009561-pg4jmvw4 82 27 and and CC cord-009561-pg4jmvw4 82 28 accompanying accompany VBG cord-009561-pg4jmvw4 82 29 AIDS AIDS NNP cord-009561-pg4jmvw4 82 30 , , , cord-009561-pg4jmvw4 82 31 when when WRB cord-009561-pg4jmvw4 82 32 unusual unusual JJ cord-009561-pg4jmvw4 82 33 myelin myelin NN cord-009561-pg4jmvw4 82 34 changes change NNS cord-009561-pg4jmvw4 82 35 are be VBP cord-009561-pg4jmvw4 82 36 seen see VBN cord-009561-pg4jmvw4 82 37 in in IN cord-009561-pg4jmvw4 82 38 the the DT cord-009561-pg4jmvw4 82 39 encephalopathy encephalopathy NN cord-009561-pg4jmvw4 82 40 and and CC cord-009561-pg4jmvw4 82 41 myelopathy myelopathy NN cord-009561-pg4jmvw4 82 42 . . . cord-009561-pg4jmvw4 83 1 AIDS AIDS NNP cord-009561-pg4jmvw4 83 2 dementia dementia NN cord-009561-pg4jmvw4 83 3 and and CC cord-009561-pg4jmvw4 83 4 myelopathy myelopathy NN cord-009561-pg4jmvw4 83 5 usually usually RB cord-009561-pg4jmvw4 83 6 evolve evolve VBP cord-009561-pg4jmvw4 83 7 insidiously insidiously RB cord-009561-pg4jmvw4 83 8 afer afer VB cord-009561-pg4jmvw4 83 9 the the DT cord-009561-pg4jmvw4 83 10 patient patient NN cord-009561-pg4jmvw4 83 11 has have VBZ cord-009561-pg4jmvw4 83 12 developed develop VBN cord-009561-pg4jmvw4 83 13 an an DT cord-009561-pg4jmvw4 83 14 AIDSdefining aidsdefine VBG cord-009561-pg4jmvw4 83 15 illness illness NN cord-009561-pg4jmvw4 83 16 . . . cord-009561-pg4jmvw4 84 1 Dementia dementia NN cord-009561-pg4jmvw4 84 2 is be VBZ cord-009561-pg4jmvw4 84 3 the the DT cord-009561-pg4jmvw4 84 4 AIDS AIDS NNP cord-009561-pg4jmvw4 84 5 - - HYPH cord-009561-pg4jmvw4 84 6 defining define VBG cord-009561-pg4jmvw4 84 7 disease disease NN cord-009561-pg4jmvw4 84 8 in in IN cord-009561-pg4jmvw4 84 9 about about IN cord-009561-pg4jmvw4 84 10 3 3 CD cord-009561-pg4jmvw4 84 11 % % NN cord-009561-pg4jmvw4 84 12 of of IN cord-009561-pg4jmvw4 84 13 the the DT cord-009561-pg4jmvw4 84 14 patients patient NNS cord-009561-pg4jmvw4 84 15 , , , cord-009561-pg4jmvw4 84 16 is be VBZ cord-009561-pg4jmvw4 84 17 evident evident JJ cord-009561-pg4jmvw4 84 18 in in IN cord-009561-pg4jmvw4 84 19 15 15 CD cord-009561-pg4jmvw4 84 20 to to TO cord-009561-pg4jmvw4 84 21 20 20 CD cord-009561-pg4jmvw4 84 22 % % NN cord-009561-pg4jmvw4 84 23 of of IN cord-009561-pg4jmvw4 84 24 ambulatory ambulatory JJ cord-009561-pg4jmvw4 84 25 AIDS AIDS NNP cord-009561-pg4jmvw4 84 26 patients patient NNS cord-009561-pg4jmvw4 84 27 [ [ -LRB- cord-009561-pg4jmvw4 84 28 58 58 CD cord-009561-pg4jmvw4 84 29 } } -RRB- cord-009561-pg4jmvw4 84 30 , , , cord-009561-pg4jmvw4 84 31 and and CC cord-009561-pg4jmvw4 84 32 may may MD cord-009561-pg4jmvw4 84 33 develop develop VB cord-009561-pg4jmvw4 84 34 in in IN cord-009561-pg4jmvw4 84 35 more more JJR cord-009561-pg4jmvw4 84 36 than than IN cord-009561-pg4jmvw4 84 37 50 50 CD cord-009561-pg4jmvw4 84 38 % % NN cord-009561-pg4jmvw4 84 39 by by IN cord-009561-pg4jmvw4 84 40 the the DT cord-009561-pg4jmvw4 84 41 time time NN cord-009561-pg4jmvw4 84 42 of of IN cord-009561-pg4jmvw4 84 43 death death NN cord-009561-pg4jmvw4 84 44 1601 1601 CD cord-009561-pg4jmvw4 84 45 . . . cord-009561-pg4jmvw4 85 1 AIDS AIDS NNP cord-009561-pg4jmvw4 85 2 dementia dementia NN cord-009561-pg4jmvw4 85 3 is be VBZ cord-009561-pg4jmvw4 85 4 a a DT cord-009561-pg4jmvw4 85 5 so so RB cord-009561-pg4jmvw4 85 6 - - HYPH cord-009561-pg4jmvw4 85 7 called call VBN cord-009561-pg4jmvw4 85 8 subcortical subcortical JJ cord-009561-pg4jmvw4 85 9 dementia dementia NN cord-009561-pg4jmvw4 85 10 with with IN cord-009561-pg4jmvw4 85 11 apathy apathy NN cord-009561-pg4jmvw4 85 12 , , , cord-009561-pg4jmvw4 85 13 memory memory NN cord-009561-pg4jmvw4 85 14 loss loss NN cord-009561-pg4jmvw4 85 15 , , , cord-009561-pg4jmvw4 85 16 and and CC cord-009561-pg4jmvw4 85 17 withdrawal withdrawal NN cord-009561-pg4jmvw4 85 18 , , , cord-009561-pg4jmvw4 85 19 and and CC cord-009561-pg4jmvw4 85 20 with with IN cord-009561-pg4jmvw4 85 21 few few JJ cord-009561-pg4jmvw4 85 22 features feature NNS cord-009561-pg4jmvw4 85 23 of of IN cord-009561-pg4jmvw4 85 24 cortical cortical JJ cord-009561-pg4jmvw4 85 25 dementia dementia NN cord-009561-pg4jmvw4 85 26 such such JJ cord-009561-pg4jmvw4 85 27 as as IN cord-009561-pg4jmvw4 85 28 behavioral behavioral JJ cord-009561-pg4jmvw4 85 29 problems problem NNS cord-009561-pg4jmvw4 85 30 and and CC cord-009561-pg4jmvw4 85 31 disorders disorder NNS cord-009561-pg4jmvw4 85 32 of of IN cord-009561-pg4jmvw4 85 33 language language NN cord-009561-pg4jmvw4 85 34 and and CC cord-009561-pg4jmvw4 85 35 perception perception NN cord-009561-pg4jmvw4 85 36 . . . cord-009561-pg4jmvw4 86 1 Signs sign NNS cord-009561-pg4jmvw4 86 2 of of IN cord-009561-pg4jmvw4 86 3 a a DT cord-009561-pg4jmvw4 86 4 myelopathy myelopathy NN cord-009561-pg4jmvw4 86 5 are be VBP cord-009561-pg4jmvw4 86 6 evident evident JJ cord-009561-pg4jmvw4 86 7 in in IN cord-009561-pg4jmvw4 86 8 approximately approximately RB cord-009561-pg4jmvw4 86 9 20 20 CD cord-009561-pg4jmvw4 86 10 % % NN cord-009561-pg4jmvw4 86 11 of of IN cord-009561-pg4jmvw4 86 12 patients patient NNS cord-009561-pg4jmvw4 86 13 by by IN cord-009561-pg4jmvw4 86 14 the the DT cord-009561-pg4jmvw4 86 15 time time NN cord-009561-pg4jmvw4 86 16 of of IN cord-009561-pg4jmvw4 86 17 death death NN cord-009561-pg4jmvw4 86 18 . . . cord-009561-pg4jmvw4 87 1 This this DT cord-009561-pg4jmvw4 87 2 often often RB cord-009561-pg4jmvw4 87 3 accompanies accompany VBZ cord-009561-pg4jmvw4 87 4 the the DT cord-009561-pg4jmvw4 87 5 encephalopathy encephalopathy NN cord-009561-pg4jmvw4 87 6 but but CC cord-009561-pg4jmvw4 87 7 can can MD cord-009561-pg4jmvw4 87 8 occur occur VB cord-009561-pg4jmvw4 87 9 independently independently RB cord-009561-pg4jmvw4 87 10 . . . cord-009561-pg4jmvw4 88 1 Patients patient NNS cord-009561-pg4jmvw4 88 2 develop develop VBP cord-009561-pg4jmvw4 88 3 weakness weakness NN cord-009561-pg4jmvw4 88 4 , , , cord-009561-pg4jmvw4 88 5 spasticity spasticity NN cord-009561-pg4jmvw4 88 6 of of IN cord-009561-pg4jmvw4 88 7 the the DT cord-009561-pg4jmvw4 88 8 legs leg NNS cord-009561-pg4jmvw4 88 9 , , , cord-009561-pg4jmvw4 88 10 and and CC cord-009561-pg4jmvw4 88 11 prominent prominent JJ cord-009561-pg4jmvw4 88 12 loss loss NN cord-009561-pg4jmvw4 88 13 of of IN cord-009561-pg4jmvw4 88 14 posterior posterior JJ cord-009561-pg4jmvw4 88 15 column column NN cord-009561-pg4jmvw4 88 16 function function NN cord-009561-pg4jmvw4 88 17 Three three CD cord-009561-pg4jmvw4 88 18 distinctive distinctive JJ cord-009561-pg4jmvw4 88 19 white white JJ cord-009561-pg4jmvw4 88 20 matter matter NN cord-009561-pg4jmvw4 88 21 lesions lesion NNS cord-009561-pg4jmvw4 88 22 are be VBP cord-009561-pg4jmvw4 88 23 found find VBN cord-009561-pg4jmvw4 88 24 in in IN cord-009561-pg4jmvw4 88 25 patients patient NNS cord-009561-pg4jmvw4 88 26 with with IN cord-009561-pg4jmvw4 88 27 encephalopathy encephalopathy NN cord-009561-pg4jmvw4 88 28 and and CC cord-009561-pg4jmvw4 88 29 myelopathy myelopathy NN cord-009561-pg4jmvw4 88 30 E621 E621 NNP cord-009561-pg4jmvw4 88 31 . . . cord-009561-pg4jmvw4 89 1 The the DT cord-009561-pg4jmvw4 89 2 pathological pathological JJ cord-009561-pg4jmvw4 89 3 finding finding NN cord-009561-pg4jmvw4 89 4 that that WDT cord-009561-pg4jmvw4 89 5 correlates correlate VBZ cord-009561-pg4jmvw4 89 6 best well RBS cord-009561-pg4jmvw4 89 7 with with IN cord-009561-pg4jmvw4 89 8 dementia dementia NN cord-009561-pg4jmvw4 89 9 is be VBZ cord-009561-pg4jmvw4 89 10 diffuse diffuse JJ cord-009561-pg4jmvw4 89 11 myelin myelin JJ cord-009561-pg4jmvw4 89 12 pallor pallor NN cord-009561-pg4jmvw4 89 13 , , , cord-009561-pg4jmvw4 89 14 which which WDT cord-009561-pg4jmvw4 89 15 is be VBZ cord-009561-pg4jmvw4 89 16 characterized characterize VBN cord-009561-pg4jmvw4 89 17 by by IN cord-009561-pg4jmvw4 89 18 hyperintensity hyperintensity NN cord-009561-pg4jmvw4 89 19 of of IN cord-009561-pg4jmvw4 89 20 T2-weighted t2-weighte VBN cord-009561-pg4jmvw4 89 21 images image NNS cord-009561-pg4jmvw4 89 22 in in IN cord-009561-pg4jmvw4 89 23 the the DT cord-009561-pg4jmvw4 89 24 deep deep JJ cord-009561-pg4jmvw4 89 25 white white JJ cord-009561-pg4jmvw4 89 26 matter matter NN cord-009561-pg4jmvw4 89 27 with with IN cord-009561-pg4jmvw4 89 28 magnetic magnetic JJ cord-009561-pg4jmvw4 89 29 resonance resonance NN cord-009561-pg4jmvw4 89 30 imaging imaging NN cord-009561-pg4jmvw4 89 31 and and CC cord-009561-pg4jmvw4 89 32 by by IN cord-009561-pg4jmvw4 89 33 reduced reduced JJ cord-009561-pg4jmvw4 89 34 intensity intensity NN cord-009561-pg4jmvw4 89 35 of of IN cord-009561-pg4jmvw4 89 36 staining staining NN cord-009561-pg4jmvw4 89 37 with with IN cord-009561-pg4jmvw4 89 38 Lux01 Lux01 NNP cord-009561-pg4jmvw4 89 39 fast fast JJ cord-009561-pg4jmvw4 89 40 blue blue NN cord-009561-pg4jmvw4 89 41 . . . cord-009561-pg4jmvw4 90 1 Immunocytochemical Immunocytochemical NNP cord-009561-pg4jmvw4 90 2 staining stain VBG cord-009561-pg4jmvw4 90 3 for for IN cord-009561-pg4jmvw4 90 4 myelin myelin NN cord-009561-pg4jmvw4 90 5 proteins protein NNS cord-009561-pg4jmvw4 90 6 does do VBZ cord-009561-pg4jmvw4 90 7 not not RB cord-009561-pg4jmvw4 90 8 show show VB cord-009561-pg4jmvw4 90 9 decrease decrease NN cord-009561-pg4jmvw4 90 10 staining stain VBG cord-009561-pg4jmvw4 90 11 intensities intensity NNS cord-009561-pg4jmvw4 90 12 in in IN cord-009561-pg4jmvw4 90 13 areas area NNS cord-009561-pg4jmvw4 90 14 of of IN cord-009561-pg4jmvw4 90 15 myelin myelin NN cord-009561-pg4jmvw4 90 16 pallor pallor NN cord-009561-pg4jmvw4 90 17 , , , cord-009561-pg4jmvw4 90 18 and and CC cord-009561-pg4jmvw4 90 19 light light NN cord-009561-pg4jmvw4 90 20 and and CC cord-009561-pg4jmvw4 90 21 electron electron NN cord-009561-pg4jmvw4 90 22 microscopic microscopic JJ cord-009561-pg4jmvw4 90 23 studies study NNS cord-009561-pg4jmvw4 90 24 fail fail VBP cord-009561-pg4jmvw4 90 25 to to TO cord-009561-pg4jmvw4 90 26 show show VB cord-009561-pg4jmvw4 90 27 demyelinated demyelinated JJ cord-009561-pg4jmvw4 90 28 axons axon NNS cord-009561-pg4jmvw4 90 29 or or CC cord-009561-pg4jmvw4 90 30 active active JJ cord-009561-pg4jmvw4 90 31 demyelination demyelination NN cord-009561-pg4jmvw4 90 32 1631 1631 CD cord-009561-pg4jmvw4 90 33 . . . cord-009561-pg4jmvw4 91 1 These these DT cord-009561-pg4jmvw4 91 2 imaging imaging NN cord-009561-pg4jmvw4 91 3 and and CC cord-009561-pg4jmvw4 91 4 staining staining NN cord-009561-pg4jmvw4 91 5 changes change NNS cord-009561-pg4jmvw4 91 6 appear appear VBP cord-009561-pg4jmvw4 91 7 to to TO cord-009561-pg4jmvw4 91 8 be be VB cord-009561-pg4jmvw4 91 9 due due JJ cord-009561-pg4jmvw4 91 10 to to IN cord-009561-pg4jmvw4 91 11 alterations alteration NNS cord-009561-pg4jmvw4 91 12 in in IN cord-009561-pg4jmvw4 91 13 the the DT cord-009561-pg4jmvw4 91 14 blood blood NN cord-009561-pg4jmvw4 91 15 - - HYPH cord-009561-pg4jmvw4 91 16 brain brain NN cord-009561-pg4jmvw4 91 17 barrier barrier NN cord-009561-pg4jmvw4 91 18 . . . cord-009561-pg4jmvw4 92 1 The the DT cord-009561-pg4jmvw4 92 2 second second JJ cord-009561-pg4jmvw4 92 3 type type NN cord-009561-pg4jmvw4 92 4 of of IN cord-009561-pg4jmvw4 92 5 white white JJ cord-009561-pg4jmvw4 92 6 matter matter NN cord-009561-pg4jmvw4 92 7 lesions lesion NNS cord-009561-pg4jmvw4 92 8 consists consist VBZ cord-009561-pg4jmvw4 92 9 of of IN cord-009561-pg4jmvw4 92 10 small small JJ cord-009561-pg4jmvw4 92 11 perivenular perivenular JJ cord-009561-pg4jmvw4 92 12 areas area NNS cord-009561-pg4jmvw4 92 13 of of IN cord-009561-pg4jmvw4 92 14 demyelination demyelination NN cord-009561-pg4jmvw4 92 15 that that WDT cord-009561-pg4jmvw4 92 16 are be VBP cord-009561-pg4jmvw4 92 17 found find VBN cord-009561-pg4jmvw4 92 18 randomly randomly RB cord-009561-pg4jmvw4 92 19 through through IN cord-009561-pg4jmvw4 92 20 white white JJ cord-009561-pg4jmvw4 92 21 matter matter NN cord-009561-pg4jmvw4 92 22 ; ; : cord-009561-pg4jmvw4 92 23 they -PRON- PRP cord-009561-pg4jmvw4 92 24 bear bear VBP cord-009561-pg4jmvw4 92 25 a a DT cord-009561-pg4jmvw4 92 26 remarkable remarkable JJ cord-009561-pg4jmvw4 92 27 resemblance resemblance NN cord-009561-pg4jmvw4 92 28 to to IN cord-009561-pg4jmvw4 92 29 the the DT cord-009561-pg4jmvw4 92 30 lesions lesion NNS cord-009561-pg4jmvw4 92 31 described describe VBN cord-009561-pg4jmvw4 92 32 above above RB cord-009561-pg4jmvw4 92 33 in in IN cord-009561-pg4jmvw4 92 34 postinfectious postinfectious NNP cord-009561-pg4jmvw4 92 35 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 92 36 . . . cord-009561-pg4jmvw4 93 1 Whether whether IN cord-009561-pg4jmvw4 93 2 these these DT cord-009561-pg4jmvw4 93 3 lesions lesion NNS cord-009561-pg4jmvw4 93 4 evolve evolve VBP cord-009561-pg4jmvw4 93 5 at at IN cord-009561-pg4jmvw4 93 6 the the DT cord-009561-pg4jmvw4 93 7 time time NN cord-009561-pg4jmvw4 93 8 of of IN cord-009561-pg4jmvw4 93 9 lymphocyte lymphocyte NN cord-009561-pg4jmvw4 93 10 activation activation NN cord-009561-pg4jmvw4 93 11 and and CC cord-009561-pg4jmvw4 93 12 autoimmune autoimmune JJ cord-009561-pg4jmvw4 93 13 diseases disease NNS cord-009561-pg4jmvw4 93 14 early early RB cord-009561-pg4jmvw4 93 15 during during IN cord-009561-pg4jmvw4 93 16 HIV HIV NNP cord-009561-pg4jmvw4 93 17 infections infection NNS cord-009561-pg4jmvw4 93 18 or or CC cord-009561-pg4jmvw4 93 19 whether whether IN cord-009561-pg4jmvw4 93 20 they -PRON- PRP cord-009561-pg4jmvw4 93 21 develop develop VBP cord-009561-pg4jmvw4 93 22 through through IN cord-009561-pg4jmvw4 93 23 some some DT cord-009561-pg4jmvw4 93 24 other other JJ cord-009561-pg4jmvw4 93 25 mechanism mechanism NN cord-009561-pg4jmvw4 93 26 is be VBZ cord-009561-pg4jmvw4 93 27 unknown unknown JJ cord-009561-pg4jmvw4 93 28 , , , cord-009561-pg4jmvw4 93 29 because because IN cord-009561-pg4jmvw4 93 30 there there EX cord-009561-pg4jmvw4 93 31 is be VBZ cord-009561-pg4jmvw4 93 32 no no DT cord-009561-pg4jmvw4 93 33 clinical clinical JJ cord-009561-pg4jmvw4 93 34 correlate correlate NN cord-009561-pg4jmvw4 93 35 for for IN cord-009561-pg4jmvw4 93 36 these these DT cord-009561-pg4jmvw4 93 37 lesions lesion NNS cord-009561-pg4jmvw4 93 38 . . . cord-009561-pg4jmvw4 94 1 The the DT cord-009561-pg4jmvw4 94 2 third third JJ cord-009561-pg4jmvw4 94 3 abnormality abnormality NN cord-009561-pg4jmvw4 94 4 is be VBZ cord-009561-pg4jmvw4 94 5 vacuolar vacuolar JJ cord-009561-pg4jmvw4 94 6 myelin myelin JJ cord-009561-pg4jmvw4 94 7 damage damage NN cord-009561-pg4jmvw4 94 8 found find VBN cord-009561-pg4jmvw4 94 9 in in IN cord-009561-pg4jmvw4 94 10 hemispheric hemispheric JJ cord-009561-pg4jmvw4 94 11 white white JJ cord-009561-pg4jmvw4 94 12 matter matter NN cord-009561-pg4jmvw4 94 13 , , , cord-009561-pg4jmvw4 94 14 fiber fiber NN cord-009561-pg4jmvw4 94 15 tracts tract NNS cord-009561-pg4jmvw4 94 16 , , , cord-009561-pg4jmvw4 94 17 and and CC cord-009561-pg4jmvw4 94 18 most most RBS cord-009561-pg4jmvw4 94 19 strikingly strikingly RB cord-009561-pg4jmvw4 94 20 in in IN cord-009561-pg4jmvw4 94 21 spinal spinal JJ cord-009561-pg4jmvw4 94 22 cord cord NN cord-009561-pg4jmvw4 94 23 primarily primarily RB cord-009561-pg4jmvw4 94 24 in in IN cord-009561-pg4jmvw4 94 25 the the DT cord-009561-pg4jmvw4 94 26 white white JJ cord-009561-pg4jmvw4 94 27 matter matter NN cord-009561-pg4jmvw4 94 28 tracts tract NNS cord-009561-pg4jmvw4 94 29 of of IN cord-009561-pg4jmvw4 94 30 the the DT cord-009561-pg4jmvw4 94 31 posterior posterior JJ cord-009561-pg4jmvw4 94 32 and and CC cord-009561-pg4jmvw4 94 33 lateral lateral JJ cord-009561-pg4jmvw4 94 34 columns column NNS cord-009561-pg4jmvw4 94 35 . . . cord-009561-pg4jmvw4 95 1 It -PRON- PRP cord-009561-pg4jmvw4 95 2 is be VBZ cord-009561-pg4jmvw4 95 3 most most RBS cord-009561-pg4jmvw4 95 4 prominent prominent JJ cord-009561-pg4jmvw4 95 5 in in IN cord-009561-pg4jmvw4 95 6 the the DT cord-009561-pg4jmvw4 95 7 thoracic thoracic JJ cord-009561-pg4jmvw4 95 8 cord cord NN cord-009561-pg4jmvw4 95 9 . . . cord-009561-pg4jmvw4 96 1 The the DT cord-009561-pg4jmvw4 96 2 vacuoles vacuole NNS cord-009561-pg4jmvw4 96 3 may may MD cord-009561-pg4jmvw4 96 4 be be VB cord-009561-pg4jmvw4 96 5 very very RB cord-009561-pg4jmvw4 96 6 asymmetrical asymmetrical JJ cord-009561-pg4jmvw4 96 7 , , , cord-009561-pg4jmvw4 96 8 few few JJ cord-009561-pg4jmvw4 96 9 perivasculat perivasculat NNP cord-009561-pg4jmvw4 96 10 inflammatory inflammatory JJ cord-009561-pg4jmvw4 96 11 cells cell NNS cord-009561-pg4jmvw4 96 12 or or CC cord-009561-pg4jmvw4 96 13 microgllal microgllal NN cord-009561-pg4jmvw4 96 14 nodules nodule NNS cord-009561-pg4jmvw4 96 15 are be VBP cord-009561-pg4jmvw4 96 16 found find VBN cord-009561-pg4jmvw4 96 17 , , , cord-009561-pg4jmvw4 96 18 and and CC cord-009561-pg4jmvw4 96 19 multinuclear multinuclear NN cord-009561-pg4jmvw4 96 20 cells cell NNS cord-009561-pg4jmvw4 96 21 are be VBP cord-009561-pg4jmvw4 96 22 rare rare JJ cord-009561-pg4jmvw4 96 23 . . . cord-009561-pg4jmvw4 97 1 Ultrastructurally Ultrastructurally NNP cord-009561-pg4jmvw4 97 2 , , , cord-009561-pg4jmvw4 97 3 vacuolitation vacuolitation NNP cord-009561-pg4jmvw4 97 4 represents represent VBZ cord-009561-pg4jmvw4 97 5 inualaminar inualaminar NNP cord-009561-pg4jmvw4 97 6 edema edema NN cord-009561-pg4jmvw4 97 7 ; ; : cord-009561-pg4jmvw4 97 8 the the DT cord-009561-pg4jmvw4 97 9 vacuoles vacuole NNS cord-009561-pg4jmvw4 97 10 are be VBP cord-009561-pg4jmvw4 97 11 not not RB cord-009561-pg4jmvw4 97 12 intracytoplasmic intracytoplasmic JJ cord-009561-pg4jmvw4 97 13 . . . cord-009561-pg4jmvw4 98 1 Macrophages macrophage NNS cord-009561-pg4jmvw4 98 2 are be VBP cord-009561-pg4jmvw4 98 3 seen see VBN cord-009561-pg4jmvw4 98 4 within within IN cord-009561-pg4jmvw4 98 5 these these DT cord-009561-pg4jmvw4 98 6 intralaminar intralaminar NNP cord-009561-pg4jmvw4 98 7 gaps gap NNS cord-009561-pg4jmvw4 98 8 . . . cord-009561-pg4jmvw4 99 1 Both both DT cord-009561-pg4jmvw4 99 2 demyelination demyelination NN cord-009561-pg4jmvw4 99 3 and and CC cord-009561-pg4jmvw4 99 4 remyelination remyelination NN cord-009561-pg4jmvw4 99 5 are be VBP cord-009561-pg4jmvw4 99 6 found find VBN cord-009561-pg4jmvw4 99 7 by by IN cord-009561-pg4jmvw4 99 8 electron electron NN cord-009561-pg4jmvw4 99 9 microscopy microscopy NN cord-009561-pg4jmvw4 99 10 1641 1641 CD cord-009561-pg4jmvw4 99 11 . . . cord-009561-pg4jmvw4 100 1 The the DT cord-009561-pg4jmvw4 100 2 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 100 3 of of IN cord-009561-pg4jmvw4 100 4 these these DT cord-009561-pg4jmvw4 100 5 myelin myelin JJ cord-009561-pg4jmvw4 100 6 changes change NNS cord-009561-pg4jmvw4 100 7 associated associate VBN cord-009561-pg4jmvw4 100 8 with with IN cord-009561-pg4jmvw4 100 9 HIV HIV NNP cord-009561-pg4jmvw4 100 10 infection infection NN cord-009561-pg4jmvw4 100 11 are be VBP cord-009561-pg4jmvw4 100 12 unknown unknown JJ cord-009561-pg4jmvw4 100 13 . . . cord-009561-pg4jmvw4 101 1 Virus virus NN cord-009561-pg4jmvw4 101 2 is be VBZ cord-009561-pg4jmvw4 101 3 usually usually RB cord-009561-pg4jmvw4 101 4 detectable detectable JJ cord-009561-pg4jmvw4 101 5 by by IN cord-009561-pg4jmvw4 101 6 immunocytochemical immunocytochemical JJ cord-009561-pg4jmvw4 101 7 staining staining NN cord-009561-pg4jmvw4 101 8 for for IN cord-009561-pg4jmvw4 101 9 HIV HIV NNP cord-009561-pg4jmvw4 101 10 antigens antigen NNS cord-009561-pg4jmvw4 101 11 and and CC cord-009561-pg4jmvw4 101 12 consistently consistently RB cord-009561-pg4jmvw4 101 13 present present JJ cord-009561-pg4jmvw4 101 14 by by IN cord-009561-pg4jmvw4 101 15 polymerase polymerase NN cord-009561-pg4jmvw4 101 16 chain chain NN cord-009561-pg4jmvw4 101 17 reactions reaction NNS cord-009561-pg4jmvw4 101 18 in in IN cord-009561-pg4jmvw4 101 19 the the DT cord-009561-pg4jmvw4 101 20 brains brain NNS cord-009561-pg4jmvw4 101 21 of of IN cord-009561-pg4jmvw4 101 22 demented demented JJ cord-009561-pg4jmvw4 101 23 patients patient NNS cord-009561-pg4jmvw4 101 24 . . . cord-009561-pg4jmvw4 102 1 Localization localization NN cord-009561-pg4jmvw4 102 2 of of IN cord-009561-pg4jmvw4 102 3 virus virus NN cord-009561-pg4jmvw4 102 4 is be VBZ cord-009561-pg4jmvw4 102 5 limited limit VBN cord-009561-pg4jmvw4 102 6 largely largely RB cord-009561-pg4jmvw4 102 7 , , , cord-009561-pg4jmvw4 102 8 if if IN cord-009561-pg4jmvw4 102 9 not not RB cord-009561-pg4jmvw4 102 10 exclusively exclusively RB cord-009561-pg4jmvw4 102 11 , , , cord-009561-pg4jmvw4 102 12 to to IN cord-009561-pg4jmvw4 102 13 cells cell NNS cord-009561-pg4jmvw4 102 14 of of IN cord-009561-pg4jmvw4 102 15 macrophage macrophage NN cord-009561-pg4jmvw4 102 16 origin origin NN cord-009561-pg4jmvw4 102 17 , , , cord-009561-pg4jmvw4 102 18 i.e. i.e. FW cord-009561-pg4jmvw4 102 19 , , , cord-009561-pg4jmvw4 102 20 microgha microgha NNP cord-009561-pg4jmvw4 102 21 , , , cord-009561-pg4jmvw4 102 22 macrophages macrophage NNS cord-009561-pg4jmvw4 102 23 , , , cord-009561-pg4jmvw4 102 24 and and CC cord-009561-pg4jmvw4 102 25 perivascular perivascular NNP cord-009561-pg4jmvw4 102 26 macrophages macrophage NNS cord-009561-pg4jmvw4 102 27 . . . cord-009561-pg4jmvw4 103 1 Limited limited JJ cord-009561-pg4jmvw4 103 2 defective defective JJ cord-009561-pg4jmvw4 103 3 infection infection NN cord-009561-pg4jmvw4 103 4 of of IN cord-009561-pg4jmvw4 103 5 astrocytes astrocyte NNS cord-009561-pg4jmvw4 103 6 may may MD cord-009561-pg4jmvw4 103 7 occur occur VB cord-009561-pg4jmvw4 103 8 , , , cord-009561-pg4jmvw4 103 9 but but CC cord-009561-pg4jmvw4 103 10 there there EX cord-009561-pg4jmvw4 103 11 is be VBZ cord-009561-pg4jmvw4 103 12 no no DT cord-009561-pg4jmvw4 103 13 convincing convincing JJ cord-009561-pg4jmvw4 103 14 evidence evidence NN cord-009561-pg4jmvw4 103 15 of of IN cord-009561-pg4jmvw4 103 16 infection infection NN cord-009561-pg4jmvw4 103 17 of of IN cord-009561-pg4jmvw4 103 18 neurons neuron NNS cord-009561-pg4jmvw4 103 19 or or CC cord-009561-pg4jmvw4 103 20 oligodendrocytes oligodendrocyte NNS cord-009561-pg4jmvw4 103 21 despite despite IN cord-009561-pg4jmvw4 103 22 the the DT cord-009561-pg4jmvw4 103 23 pathological pathological JJ cord-009561-pg4jmvw4 103 24 changes change NNS cord-009561-pg4jmvw4 103 25 in in IN cord-009561-pg4jmvw4 103 26 these these DT cord-009561-pg4jmvw4 103 27 cells cell NNS cord-009561-pg4jmvw4 103 28 or or CC cord-009561-pg4jmvw4 103 29 their -PRON- PRP$ cord-009561-pg4jmvw4 103 30 membranes membrane NNS cord-009561-pg4jmvw4 103 31 . . . cord-009561-pg4jmvw4 104 1 The the DT cord-009561-pg4jmvw4 104 2 alterations alteration NNS cord-009561-pg4jmvw4 104 3 in in IN cord-009561-pg4jmvw4 104 4 myelin myelin JJ cord-009561-pg4jmvw4 104 5 membranes membrane NNS cord-009561-pg4jmvw4 104 6 and and CC cord-009561-pg4jmvw4 104 7 neurons neuron NNS cord-009561-pg4jmvw4 104 8 are be VBP cord-009561-pg4jmvw4 104 9 thought think VBN cord-009561-pg4jmvw4 104 10 to to TO cord-009561-pg4jmvw4 104 11 be be VB cord-009561-pg4jmvw4 104 12 mediated mediate VBN cord-009561-pg4jmvw4 104 13 by by IN cord-009561-pg4jmvw4 104 14 secretory secretory JJ cord-009561-pg4jmvw4 104 15 products product NNS cord-009561-pg4jmvw4 104 16 of of IN cord-009561-pg4jmvw4 104 17 infected infected JJ cord-009561-pg4jmvw4 104 18 macrophages macrophage NNS cord-009561-pg4jmvw4 104 19 and and CC cord-009561-pg4jmvw4 104 20 microgha microgha NNP cord-009561-pg4jmvw4 104 21 Virus virus NN cord-009561-pg4jmvw4 104 22 proteins protein NNS cord-009561-pg4jmvw4 104 23 , , , cord-009561-pg4jmvw4 104 24 cytokines cytokine NNS cord-009561-pg4jmvw4 104 25 and and CC cord-009561-pg4jmvw4 104 26 neurotoxins neurotoxin NNS cord-009561-pg4jmvw4 104 27 have have VBP cord-009561-pg4jmvw4 104 28 d d VBN cord-009561-pg4jmvw4 104 29 been be VBN cord-009561-pg4jmvw4 104 30 implicated implicate VBN cord-009561-pg4jmvw4 104 31 either either CC cord-009561-pg4jmvw4 104 32 directly directly RB cord-009561-pg4jmvw4 104 33 or or CC cord-009561-pg4jmvw4 104 34 via via IN cord-009561-pg4jmvw4 104 35 indirect indirect JJ cord-009561-pg4jmvw4 104 36 effects effect NNS cord-009561-pg4jmvw4 104 37 on on IN cord-009561-pg4jmvw4 104 38 astrocytes astrocyte NNS cord-009561-pg4jmvw4 104 39 or or CC cord-009561-pg4jmvw4 104 40 ohgodendrocytes ohgodendrocyte NNS cord-009561-pg4jmvw4 104 41 165 165 CD cord-009561-pg4jmvw4 104 42 , , , cord-009561-pg4jmvw4 104 43 661 661 CD cord-009561-pg4jmvw4 104 44 . . . cord-009561-pg4jmvw4 105 1 In in IN cord-009561-pg4jmvw4 105 2 visna visna NNS cord-009561-pg4jmvw4 105 3 , , , cord-009561-pg4jmvw4 105 4 another another DT cord-009561-pg4jmvw4 105 5 lentivirus lentivirus NN cord-009561-pg4jmvw4 105 6 infection infection NN cord-009561-pg4jmvw4 105 7 , , , cord-009561-pg4jmvw4 105 8 infected infected JJ cord-009561-pg4jmvw4 105 9 monocytes monocyte NNS cord-009561-pg4jmvw4 105 10 when when WRB cord-009561-pg4jmvw4 105 11 they -PRON- PRP cord-009561-pg4jmvw4 105 12 differentiate differentiate VBP cord-009561-pg4jmvw4 105 13 into into IN cord-009561-pg4jmvw4 105 14 tissue tissue NN cord-009561-pg4jmvw4 105 15 macrophages macrophage NNS cord-009561-pg4jmvw4 105 16 express express VBP cord-009561-pg4jmvw4 105 17 surface surface NN cord-009561-pg4jmvw4 105 18 viral viral JJ cord-009561-pg4jmvw4 105 19 proteins protein NNS cord-009561-pg4jmvw4 105 20 that that WDT cord-009561-pg4jmvw4 105 21 , , , cord-009561-pg4jmvw4 105 22 in in IN cord-009561-pg4jmvw4 105 23 turn turn NN cord-009561-pg4jmvw4 105 24 , , , cord-009561-pg4jmvw4 105 25 induce induce VB cord-009561-pg4jmvw4 105 26 neighboring neighboring NN cord-009561-pg4jmvw4 105 27 lymphocytes lymphocyte NNS cord-009561-pg4jmvw4 105 28 to to TO cord-009561-pg4jmvw4 105 29 release release VB cord-009561-pg4jmvw4 105 30 a a DT cord-009561-pg4jmvw4 105 31 lymphokine lymphokine NN cord-009561-pg4jmvw4 105 32 that that WDT cord-009561-pg4jmvw4 105 33 induces induce VBZ cord-009561-pg4jmvw4 105 34 class class NN cord-009561-pg4jmvw4 105 35 I1 i1 NN cord-009561-pg4jmvw4 105 36 antigen antigen NN cord-009561-pg4jmvw4 105 37 expression expression NN cord-009561-pg4jmvw4 105 38 on on IN cord-009561-pg4jmvw4 105 39 endothelial endothelial JJ cord-009561-pg4jmvw4 105 40 and and CC cord-009561-pg4jmvw4 105 41 possibly possibly RB cord-009561-pg4jmvw4 105 42 ghal ghal NN cord-009561-pg4jmvw4 105 43 cells cell NNS cord-009561-pg4jmvw4 105 44 [ [ -LRB- cord-009561-pg4jmvw4 105 45 67 67 CD cord-009561-pg4jmvw4 105 46 } } -RRB- cord-009561-pg4jmvw4 105 47 . . . cord-009561-pg4jmvw4 106 1 Marked marked JJ cord-009561-pg4jmvw4 106 2 inflammation inflammation NN cord-009561-pg4jmvw4 106 3 ensues ensue VBZ cord-009561-pg4jmvw4 106 4 . . . cord-009561-pg4jmvw4 107 1 A a DT cord-009561-pg4jmvw4 107 2 similar similar JJ cord-009561-pg4jmvw4 107 3 cytokine cytokine NN cord-009561-pg4jmvw4 107 4 - - HYPH cord-009561-pg4jmvw4 107 5 mediated mediate VBN cord-009561-pg4jmvw4 107 6 disease disease NN cord-009561-pg4jmvw4 107 7 has have VBZ cord-009561-pg4jmvw4 107 8 been be VBN cord-009561-pg4jmvw4 107 9 postulated postulate VBN cord-009561-pg4jmvw4 107 10 in in IN cord-009561-pg4jmvw4 107 11 HIV HIV NNP cord-009561-pg4jmvw4 107 12 infection infection NN cord-009561-pg4jmvw4 107 13 , , , cord-009561-pg4jmvw4 107 14 and and CC cord-009561-pg4jmvw4 107 15 the the DT cord-009561-pg4jmvw4 107 16 correlation correlation NN cord-009561-pg4jmvw4 107 17 of of IN cord-009561-pg4jmvw4 107 18 tumor tumor NN cord-009561-pg4jmvw4 107 19 necrosis necrosis NN cord-009561-pg4jmvw4 107 20 factor factor NN cord-009561-pg4jmvw4 107 21 * * NFP cord-009561-pg4jmvw4 107 22 levels level NNS cord-009561-pg4jmvw4 107 23 to to IN cord-009561-pg4jmvw4 107 24 the the DT cord-009561-pg4jmvw4 107 25 dementia dementia NN cord-009561-pg4jmvw4 107 26 and and CC cord-009561-pg4jmvw4 107 27 myelopathy myelopathy NN cord-009561-pg4jmvw4 107 28 168 168 CD cord-009561-pg4jmvw4 107 29 , , , cord-009561-pg4jmvw4 107 30 693 693 CD cord-009561-pg4jmvw4 107 31 would would MD cord-009561-pg4jmvw4 107 32 be be VB cord-009561-pg4jmvw4 107 33 consistent consistent JJ cord-009561-pg4jmvw4 107 34 with with IN cord-009561-pg4jmvw4 107 35 such such PDT cord-009561-pg4jmvw4 107 36 a a DT cord-009561-pg4jmvw4 107 37 speculation speculation NN cord-009561-pg4jmvw4 107 38 . . . cord-009561-pg4jmvw4 108 1 More More JJR cord-009561-pg4jmvw4 108 2 than than IN cord-009561-pg4jmvw4 108 3 a a DT cord-009561-pg4jmvw4 108 4 century century NN cord-009561-pg4jmvw4 108 5 has have VBZ cord-009561-pg4jmvw4 108 6 past past NN cord-009561-pg4jmvw4 108 7 since since IN cord-009561-pg4jmvw4 108 8 Pierre Pierre NNP cord-009561-pg4jmvw4 108 9 Marie Marie NNP cord-009561-pg4jmvw4 108 10 postulated postulate VBD cord-009561-pg4jmvw4 108 11 an an DT cord-009561-pg4jmvw4 108 12 infectious infectious JJ cord-009561-pg4jmvw4 108 13 agent agent NN cord-009561-pg4jmvw4 108 14 in in IN cord-009561-pg4jmvw4 108 15 multiple multiple JJ cord-009561-pg4jmvw4 108 16 sclerosis sclerosis NN cord-009561-pg4jmvw4 108 17 , , , cord-009561-pg4jmvw4 108 18 and and CC cord-009561-pg4jmvw4 108 19 a a DT cord-009561-pg4jmvw4 108 20 number number NN cord-009561-pg4jmvw4 108 21 of of IN cord-009561-pg4jmvw4 108 22 virus virus NN cord-009561-pg4jmvw4 108 23 isolations isolation NNS cord-009561-pg4jmvw4 108 24 have have VBP cord-009561-pg4jmvw4 108 25 been be VBN cord-009561-pg4jmvw4 108 26 reported report VBN cord-009561-pg4jmvw4 108 27 , , , cord-009561-pg4jmvw4 108 28 but but CC cord-009561-pg4jmvw4 108 29 none none NN cord-009561-pg4jmvw4 108 30 have have VBP cord-009561-pg4jmvw4 108 31 been be VBN cord-009561-pg4jmvw4 108 32 convincingly convincingly RB cord-009561-pg4jmvw4 108 33 linked link VBN cord-009561-pg4jmvw4 108 34 to to IN cord-009561-pg4jmvw4 108 35 the the DT cord-009561-pg4jmvw4 108 36 disease disease NN cord-009561-pg4jmvw4 108 37 ( ( -LRB- cord-009561-pg4jmvw4 108 38 Table table NN cord-009561-pg4jmvw4 108 39 4 4 CD cord-009561-pg4jmvw4 108 40 ) ) -RRB- cord-009561-pg4jmvw4 108 41 . . . cord-009561-pg4jmvw4 109 1 Even even RB cord-009561-pg4jmvw4 109 2 those those DT cord-009561-pg4jmvw4 109 3 who who WP cord-009561-pg4jmvw4 109 4 hold hold VBP cord-009561-pg4jmvw4 109 5 to to IN cord-009561-pg4jmvw4 109 6 the the DT cord-009561-pg4jmvw4 109 7 idea idea NN cord-009561-pg4jmvw4 109 8 of of IN cord-009561-pg4jmvw4 109 9 a a DT cord-009561-pg4jmvw4 109 10 viral viral JJ cord-009561-pg4jmvw4 109 11 etiology etiology NN cord-009561-pg4jmvw4 109 12 are be VBP cord-009561-pg4jmvw4 109 13 undecided undecided JJ cord-009561-pg4jmvw4 109 14 whether whether IN cord-009561-pg4jmvw4 109 15 it -PRON- PRP cord-009561-pg4jmvw4 109 16 may may MD cord-009561-pg4jmvw4 109 17 be be VB cord-009561-pg4jmvw4 109 18 many many JJ cord-009561-pg4jmvw4 109 19 viruses virus NNS cord-009561-pg4jmvw4 109 20 or or CC cord-009561-pg4jmvw4 109 21 only only RB cord-009561-pg4jmvw4 109 22 one one CD cord-009561-pg4jmvw4 109 23 , , , cord-009561-pg4jmvw4 109 24 whether whether IN cord-009561-pg4jmvw4 109 25 a a DT cord-009561-pg4jmvw4 109 26 childhood childhood NN cord-009561-pg4jmvw4 109 27 viral viral JJ cord-009561-pg4jmvw4 109 28 infection infection NN cord-009561-pg4jmvw4 109 29 is be VBZ cord-009561-pg4jmvw4 109 30 important important JJ cord-009561-pg4jmvw4 109 31 for for IN cord-009561-pg4jmvw4 109 32 laying lay VBG cord-009561-pg4jmvw4 109 33 the the DT cord-009561-pg4jmvw4 109 34 ground ground NN cord-009561-pg4jmvw4 109 35 work work NN cord-009561-pg4jmvw4 109 36 of of IN cord-009561-pg4jmvw4 109 37 the the DT cord-009561-pg4jmvw4 109 38 disease disease NN cord-009561-pg4jmvw4 109 39 , , , cord-009561-pg4jmvw4 109 40 the the DT cord-009561-pg4jmvw4 109 41 so so RB cord-009561-pg4jmvw4 109 42 - - HYPH cord-009561-pg4jmvw4 109 43 called call VBN cord-009561-pg4jmvw4 109 44 common common JJ cord-009561-pg4jmvw4 109 45 exposure exposure NN cord-009561-pg4jmvw4 109 46 factor factor NN cord-009561-pg4jmvw4 109 47 , , , cord-009561-pg4jmvw4 109 48 or or CC cord-009561-pg4jmvw4 109 49 whether whether IN cord-009561-pg4jmvw4 109 50 one one CD cord-009561-pg4jmvw4 109 51 or or CC cord-009561-pg4jmvw4 109 52 many many JJ cord-009561-pg4jmvw4 109 53 viruses virus NNS cord-009561-pg4jmvw4 109 54 may may MD cord-009561-pg4jmvw4 109 55 precipitate precipitate VB cord-009561-pg4jmvw4 109 56 exacerbations exacerbation NNS cord-009561-pg4jmvw4 109 57 . . . cord-009561-pg4jmvw4 110 1 What what WP cord-009561-pg4jmvw4 110 2 have have VBP cord-009561-pg4jmvw4 110 3 we -PRON- PRP cord-009561-pg4jmvw4 110 4 learned learn VBN cord-009561-pg4jmvw4 110 5 from from IN cord-009561-pg4jmvw4 110 6 other other JJ cord-009561-pg4jmvw4 110 7 demyelinating demyelinating JJ cord-009561-pg4jmvw4 110 8 diseases disease NNS cord-009561-pg4jmvw4 110 9 ? ? . cord-009561-pg4jmvw4 111 1 We -PRON- PRP cord-009561-pg4jmvw4 111 2 have have VBP cord-009561-pg4jmvw4 111 3 learned learn VBN cord-009561-pg4jmvw4 111 4 that that IN cord-009561-pg4jmvw4 111 5 viruses virus NNS cord-009561-pg4jmvw4 111 6 can can MD cord-009561-pg4jmvw4 111 7 produce produce VB cord-009561-pg4jmvw4 111 8 disease disease NN cord-009561-pg4jmvw4 111 9 with with IN cord-009561-pg4jmvw4 111 10 long long JJ cord-009561-pg4jmvw4 111 11 incubation incubation NN cord-009561-pg4jmvw4 111 12 periods period NNS cord-009561-pg4jmvw4 111 13 , , , cord-009561-pg4jmvw4 111 14 remimng remimng NN cord-009561-pg4jmvw4 111 15 and and CC cord-009561-pg4jmvw4 111 16 relapsing relapse VBG cord-009561-pg4jmvw4 111 17 courses course NNS cord-009561-pg4jmvw4 111 18 , , , cord-009561-pg4jmvw4 111 19 and and CC cord-009561-pg4jmvw4 111 20 the the DT cord-009561-pg4jmvw4 111 21 loss loss NN cord-009561-pg4jmvw4 111 22 of of IN cord-009561-pg4jmvw4 111 23 myelin myelin NN cord-009561-pg4jmvw4 111 24 with with IN cord-009561-pg4jmvw4 111 25 relative relative JJ cord-009561-pg4jmvw4 111 26 sparing sparing NN cord-009561-pg4jmvw4 111 27 of of IN cord-009561-pg4jmvw4 111 28 axons axon NNS cord-009561-pg4jmvw4 111 29 . . . cord-009561-pg4jmvw4 112 1 In in IN cord-009561-pg4jmvw4 112 2 the the DT cord-009561-pg4jmvw4 112 3 case case NN cord-009561-pg4jmvw4 112 4 of of IN cord-009561-pg4jmvw4 112 5 progressive progressive JJ cord-009561-pg4jmvw4 112 6 multifocal multifocal JJ cord-009561-pg4jmvw4 112 7 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 112 8 , , , cord-009561-pg4jmvw4 112 9 the the DT cord-009561-pg4jmvw4 112 10 most most RBS cord-009561-pg4jmvw4 112 11 straightforward straightforward JJ cord-009561-pg4jmvw4 112 12 mechanism mechanism NN cord-009561-pg4jmvw4 112 13 of of IN cord-009561-pg4jmvw4 112 14 demyelination demyelination NN cord-009561-pg4jmvw4 112 15 proved prove VBN cord-009561-pg4jmvw4 112 16 operative operative JJ cord-009561-pg4jmvw4 112 17 , , , cord-009561-pg4jmvw4 112 18 i.e. i.e. FW cord-009561-pg4jmvw4 112 19 , , , cord-009561-pg4jmvw4 112 20 selective selective JJ cord-009561-pg4jmvw4 112 21 infection infection NN cord-009561-pg4jmvw4 112 22 destroys destroy VBZ cord-009561-pg4jmvw4 112 23 ohgodendrocytes ohgodendrocyte NNS cord-009561-pg4jmvw4 112 24 . . . cord-009561-pg4jmvw4 113 1 The the DT cord-009561-pg4jmvw4 113 2 identification identification NN cord-009561-pg4jmvw4 113 3 of of IN cord-009561-pg4jmvw4 113 4 the the DT cord-009561-pg4jmvw4 113 5 infectious infectious JJ cord-009561-pg4jmvw4 113 6 agent agent NN cord-009561-pg4jmvw4 113 7 , , , cord-009561-pg4jmvw4 113 8 however however RB cord-009561-pg4jmvw4 113 9 , , , cord-009561-pg4jmvw4 113 10 required require VBD cord-009561-pg4jmvw4 113 11 two two CD cord-009561-pg4jmvw4 113 12 steps step NNS cord-009561-pg4jmvw4 113 13 . . . cord-009561-pg4jmvw4 114 1 First first RB cord-009561-pg4jmvw4 114 2 , , , cord-009561-pg4jmvw4 114 3 electron electron NN cord-009561-pg4jmvw4 114 4 microscopic microscopic JJ cord-009561-pg4jmvw4 114 5 studies study NNS cord-009561-pg4jmvw4 114 6 were be VBD cord-009561-pg4jmvw4 114 7 necessary necessary JJ cord-009561-pg4jmvw4 114 8 to to TO cord-009561-pg4jmvw4 114 9 know know VB cord-009561-pg4jmvw4 114 10 what what WP cord-009561-pg4jmvw4 114 11 kind kind NN cord-009561-pg4jmvw4 114 12 of of IN cord-009561-pg4jmvw4 114 13 viruses virus NNS cord-009561-pg4jmvw4 114 14 to to TO cord-009561-pg4jmvw4 114 15 look look VB cord-009561-pg4jmvw4 114 16 for for IN cord-009561-pg4jmvw4 114 17 , , , cord-009561-pg4jmvw4 114 18 and and CC cord-009561-pg4jmvw4 114 19 second second JJ cord-009561-pg4jmvw4 114 20 , , , cord-009561-pg4jmvw4 114 21 laboratory laboratory NN cord-009561-pg4jmvw4 114 22 methods method NNS cord-009561-pg4jmvw4 114 23 had have VBD cord-009561-pg4jmvw4 114 24 to to TO cord-009561-pg4jmvw4 114 25 be be VB cord-009561-pg4jmvw4 114 26 developed develop VBN cord-009561-pg4jmvw4 114 27 to to TO cord-009561-pg4jmvw4 114 28 recover recover VB cord-009561-pg4jmvw4 114 29 a a DT cord-009561-pg4jmvw4 114 30 new new JJ cord-009561-pg4jmvw4 114 31 and and CC cord-009561-pg4jmvw4 114 32 previously previously RB cord-009561-pg4jmvw4 114 33 unknown unknown JJ cord-009561-pg4jmvw4 114 34 papovavirus papovavirus NN cord-009561-pg4jmvw4 114 35 . . . cord-009561-pg4jmvw4 115 1 In in IN cord-009561-pg4jmvw4 115 2 posuneasles posuneasle NNS cord-009561-pg4jmvw4 115 3 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 115 4 and and CC cord-009561-pg4jmvw4 115 5 in in IN cord-009561-pg4jmvw4 115 6 HIV HIV NNP cord-009561-pg4jmvw4 115 7 infections infection NNS cord-009561-pg4jmvw4 115 8 , , , cord-009561-pg4jmvw4 115 9 no no DT cord-009561-pg4jmvw4 115 10 infection infection NN cord-009561-pg4jmvw4 115 11 of of IN cord-009561-pg4jmvw4 115 12 oligodendrocytes oligodendrocyte NNS cord-009561-pg4jmvw4 115 13 has have VBZ cord-009561-pg4jmvw4 115 14 been be VBN cord-009561-pg4jmvw4 115 15 found find VBN cord-009561-pg4jmvw4 115 16 to to TO cord-009561-pg4jmvw4 115 17 explain explain VB cord-009561-pg4jmvw4 115 18 virus virus NN cord-009561-pg4jmvw4 115 19 - - HYPH cord-009561-pg4jmvw4 115 20 induced induce VBN cord-009561-pg4jmvw4 115 21 demyelination demyelination NN cord-009561-pg4jmvw4 115 22 . . . cord-009561-pg4jmvw4 116 1 In in IN cord-009561-pg4jmvw4 116 2 postmeasles postmeasle NNS cord-009561-pg4jmvw4 116 3 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 116 4 the the DT cord-009561-pg4jmvw4 116 5 etiologic etiologic JJ cord-009561-pg4jmvw4 116 6 agent agent NN cord-009561-pg4jmvw4 116 7 has have VBZ cord-009561-pg4jmvw4 116 8 been be VBN cord-009561-pg4jmvw4 116 9 identified identify VBN cord-009561-pg4jmvw4 116 10 only only RB cord-009561-pg4jmvw4 116 11 by by IN cord-009561-pg4jmvw4 116 12 the the DT cord-009561-pg4jmvw4 116 13 very very RB cord-009561-pg4jmvw4 116 14 characteristic characteristic JJ cord-009561-pg4jmvw4 116 15 manifestation manifestation NN cord-009561-pg4jmvw4 116 16 of of IN cord-009561-pg4jmvw4 116 17 the the DT cord-009561-pg4jmvw4 116 18 systemic systemic JJ cord-009561-pg4jmvw4 116 19 disease disease NN cord-009561-pg4jmvw4 116 20 . . . cord-009561-pg4jmvw4 117 1 At at IN cord-009561-pg4jmvw4 117 2 the the DT cord-009561-pg4jmvw4 117 3 time time NN cord-009561-pg4jmvw4 117 4 encephalitis encephalitis RB cord-009561-pg4jmvw4 117 5 develops develop VBZ cord-009561-pg4jmvw4 117 6 , , , cord-009561-pg4jmvw4 117 7 usually usually RB cord-009561-pg4jmvw4 117 8 no no DT cord-009561-pg4jmvw4 117 9 intrathecal intrathecal JJ cord-009561-pg4jmvw4 117 10 antibody antibody NN cord-009561-pg4jmvw4 117 11 synthesis synthesis NN cord-009561-pg4jmvw4 117 12 is be VBZ cord-009561-pg4jmvw4 117 13 found find VBN cord-009561-pg4jmvw4 117 14 and and CC cord-009561-pg4jmvw4 117 15 the the DT cord-009561-pg4jmvw4 117 16 virus virus NN cord-009561-pg4jmvw4 117 17 is be VBZ cord-009561-pg4jmvw4 117 18 not not RB cord-009561-pg4jmvw4 117 19 recovered recover VBN cord-009561-pg4jmvw4 117 20 from from IN cord-009561-pg4jmvw4 117 21 the the DT cord-009561-pg4jmvw4 117 22 central central JJ cord-009561-pg4jmvw4 117 23 nervous nervous JJ cord-009561-pg4jmvw4 117 24 system system NN cord-009561-pg4jmvw4 117 25 . . . cord-009561-pg4jmvw4 118 1 Indeed indeed RB cord-009561-pg4jmvw4 118 2 , , , cord-009561-pg4jmvw4 118 3 OUT OUT NNP cord-009561-pg4jmvw4 118 4 studies study NNS cord-009561-pg4jmvw4 118 5 suggest suggest VBP cord-009561-pg4jmvw4 118 6 that that IN cord-009561-pg4jmvw4 118 7 virus virus NN cord-009561-pg4jmvw4 118 8 may may MD cord-009561-pg4jmvw4 118 9 have have VB cord-009561-pg4jmvw4 118 10 never never RB cord-009561-pg4jmvw4 118 11 been be VBN cord-009561-pg4jmvw4 118 12 in in IN cord-009561-pg4jmvw4 118 13 the the DT cord-009561-pg4jmvw4 118 14 central central JJ cord-009561-pg4jmvw4 118 15 nervous nervous JJ cord-009561-pg4jmvw4 118 16 system system NN cord-009561-pg4jmvw4 118 17 . . . cord-009561-pg4jmvw4 119 1 In in IN cord-009561-pg4jmvw4 119 2 this this DT cord-009561-pg4jmvw4 119 3 disease disease NN cord-009561-pg4jmvw4 119 4 an an DT cord-009561-pg4jmvw4 119 5 indirect indirect JJ cord-009561-pg4jmvw4 119 6 mechanism mechanism NN cord-009561-pg4jmvw4 119 7 may may MD cord-009561-pg4jmvw4 119 8 be be VB cord-009561-pg4jmvw4 119 9 operative operative JJ cord-009561-pg4jmvw4 119 10 , , , cord-009561-pg4jmvw4 119 11 and and CC cord-009561-pg4jmvw4 119 12 if if IN cord-009561-pg4jmvw4 119 13 an an DT cord-009561-pg4jmvw4 119 14 anale anale JJ cord-009561-pg4jmvw4 119 15 gous gous JJ cord-009561-pg4jmvw4 119 16 mechanism mechanism NN cord-009561-pg4jmvw4 119 17 occurred occur VBD cord-009561-pg4jmvw4 119 18 in in IN cord-009561-pg4jmvw4 119 19 multiple multiple JJ cord-009561-pg4jmvw4 119 20 sclerosis sclerosis NN cord-009561-pg4jmvw4 119 21 virus virus NN cord-009561-pg4jmvw4 119 22 would would MD cord-009561-pg4jmvw4 119 23 need need VB cord-009561-pg4jmvw4 119 24 to to TO cord-009561-pg4jmvw4 119 25 be be VB cord-009561-pg4jmvw4 119 26 sought seek VBN cord-009561-pg4jmvw4 119 27 in in IN cord-009561-pg4jmvw4 119 28 lymphoid lymphoid JJ cord-009561-pg4jmvw4 119 29 tissues tissue NNS cord-009561-pg4jmvw4 119 30 prior prior RB cord-009561-pg4jmvw4 119 31 to to IN cord-009561-pg4jmvw4 119 32 the the DT cord-009561-pg4jmvw4 119 33 clinical clinical JJ cord-009561-pg4jmvw4 119 34 manifestations manifestation NNS cord-009561-pg4jmvw4 119 35 of of IN cord-009561-pg4jmvw4 119 36 the the DT cord-009561-pg4jmvw4 119 37 demyelinating demyelinating JJ cord-009561-pg4jmvw4 119 38 disease disease NN cord-009561-pg4jmvw4 119 39 . . . cord-009561-pg4jmvw4 120 1 Demyelination Demyelination NNP cord-009561-pg4jmvw4 120 2 of of IN cord-009561-pg4jmvw4 120 3 the the DT cord-009561-pg4jmvw4 120 4 central central JJ cord-009561-pg4jmvw4 120 5 nervous nervous JJ cord-009561-pg4jmvw4 120 6 system system NN cord-009561-pg4jmvw4 120 7 in in IN cord-009561-pg4jmvw4 120 8 AIDS AIDS NNP cord-009561-pg4jmvw4 120 9 shows show VBZ cord-009561-pg4jmvw4 120 10 unique unique JJ cord-009561-pg4jmvw4 120 11 morphological morphological JJ cord-009561-pg4jmvw4 120 12 changes change NNS cord-009561-pg4jmvw4 120 13 in in IN cord-009561-pg4jmvw4 120 14 a a DT cord-009561-pg4jmvw4 120 15 new new JJ cord-009561-pg4jmvw4 120 16 disease disease NN cord-009561-pg4jmvw4 120 17 , , , cord-009561-pg4jmvw4 120 18 due due IN cord-009561-pg4jmvw4 120 19 to to IN cord-009561-pg4jmvw4 120 20 a a DT cord-009561-pg4jmvw4 120 21 new new JJ cord-009561-pg4jmvw4 120 22 virus virus NN cord-009561-pg4jmvw4 120 23 . . . cord-009561-pg4jmvw4 121 1 The the DT cord-009561-pg4jmvw4 121 2 virus virus NN cord-009561-pg4jmvw4 121 3 is be VBZ cord-009561-pg4jmvw4 121 4 present present JJ cord-009561-pg4jmvw4 121 5 in in IN cord-009561-pg4jmvw4 121 6 the the DT cord-009561-pg4jmvw4 121 7 central central JJ cord-009561-pg4jmvw4 121 8 nervous nervous JJ cord-009561-pg4jmvw4 121 9 system system NN cord-009561-pg4jmvw4 121 10 , , , cord-009561-pg4jmvw4 121 11 but but CC cord-009561-pg4jmvw4 121 12 it -PRON- PRP cord-009561-pg4jmvw4 121 13 is be VBZ cord-009561-pg4jmvw4 121 14 present present JJ cord-009561-pg4jmvw4 121 15 in in IN cord-009561-pg4jmvw4 121 16 the the DT cord-009561-pg4jmvw4 121 17 " " `` cord-009561-pg4jmvw4 121 18 wrong wrong JJ cord-009561-pg4jmvw4 121 19 " " '' cord-009561-pg4jmvw4 121 20 cells cell NNS cord-009561-pg4jmvw4 121 21 ; ; : cord-009561-pg4jmvw4 121 22 a a DT cord-009561-pg4jmvw4 121 23 correlation correlation NN cord-009561-pg4jmvw4 121 24 between between IN cord-009561-pg4jmvw4 121 25 the the DT cord-009561-pg4jmvw4 121 26 amount amount NN cord-009561-pg4jmvw4 121 27 of of IN cord-009561-pg4jmvw4 121 28 virus virus NN cord-009561-pg4jmvw4 121 29 and and CC cord-009561-pg4jmvw4 121 30 the the DT cord-009561-pg4jmvw4 121 31 amount amount NN cord-009561-pg4jmvw4 121 32 of of IN cord-009561-pg4jmvw4 121 33 disease disease NN cord-009561-pg4jmvw4 121 34 is be VBZ cord-009561-pg4jmvw4 121 35 lacking lack VBG cord-009561-pg4jmvw4 121 36 , , , cord-009561-pg4jmvw4 121 37 making make VBG cord-009561-pg4jmvw4 121 38 it -PRON- PRP cord-009561-pg4jmvw4 121 39 hard hard JJ cord-009561-pg4jmvw4 121 40 to to TO cord-009561-pg4jmvw4 121 41 fulfill fulfill VB cord-009561-pg4jmvw4 121 42 even even RB cord-009561-pg4jmvw4 121 43 the the DT cord-009561-pg4jmvw4 121 44 most most RBS cord-009561-pg4jmvw4 121 45 liberal liberal JJ cord-009561-pg4jmvw4 121 46 modifications modification NNS cord-009561-pg4jmvw4 121 47 of of IN cord-009561-pg4jmvw4 121 48 Koch Koch NNP cord-009561-pg4jmvw4 121 49 's 's POS cord-009561-pg4jmvw4 121 50 postulates postulate NNS cord-009561-pg4jmvw4 121 51 [ [ -LRB- cord-009561-pg4jmvw4 121 52 86 86 CD cord-009561-pg4jmvw4 121 53 ] ] -RRB- cord-009561-pg4jmvw4 121 54 . . . cord-009561-pg4jmvw4 122 1 The the DT cord-009561-pg4jmvw4 122 2 obvious obvious JJ cord-009561-pg4jmvw4 122 3 mediators mediator NNS cord-009561-pg4jmvw4 122 4 of of IN cord-009561-pg4jmvw4 122 5 demyelination demyelination NN cord-009561-pg4jmvw4 122 6 appear appear VBP cord-009561-pg4jmvw4 122 7 to to TO cord-009561-pg4jmvw4 122 8 be be VB cord-009561-pg4jmvw4 122 9 virally virally RB cord-009561-pg4jmvw4 122 10 infected infect VBN cord-009561-pg4jmvw4 122 11 macrophages macrophage NNS cord-009561-pg4jmvw4 122 12 or or CC cord-009561-pg4jmvw4 122 13 microglta microglta NNS cord-009561-pg4jmvw4 122 14 and and CC cord-009561-pg4jmvw4 122 15 current current JJ cord-009561-pg4jmvw4 122 16 work work NN cord-009561-pg4jmvw4 122 17 focuses focus VBZ cord-009561-pg4jmvw4 122 18 on on IN cord-009561-pg4jmvw4 122 19 the the DT cord-009561-pg4jmvw4 122 20 possible possible JJ cord-009561-pg4jmvw4 122 21 role role NN cord-009561-pg4jmvw4 122 22 of of IN cord-009561-pg4jmvw4 122 23 their -PRON- PRP$ cord-009561-pg4jmvw4 122 24 soluble soluble JJ cord-009561-pg4jmvw4 122 25 products product NNS cord-009561-pg4jmvw4 122 26 in in IN cord-009561-pg4jmvw4 122 27 disruption disruption NN cord-009561-pg4jmvw4 122 28 of of IN cord-009561-pg4jmvw4 122 29 myelin myelin NN cord-009561-pg4jmvw4 122 30 sheaths sheath NNS cord-009561-pg4jmvw4 122 31 . . . cord-009561-pg4jmvw4 123 1 In in IN cord-009561-pg4jmvw4 123 2 these these DT cord-009561-pg4jmvw4 123 3 studies study NNS cord-009561-pg4jmvw4 123 4 the the DT cord-009561-pg4jmvw4 123 5 knowledge knowledge NN cord-009561-pg4jmvw4 123 6 of of IN cord-009561-pg4jmvw4 123 7 what what WP cord-009561-pg4jmvw4 123 8 virus virus NN cord-009561-pg4jmvw4 123 9 to to TO cord-009561-pg4jmvw4 123 10 look look VB cord-009561-pg4jmvw4 123 11 for for IN cord-009561-pg4jmvw4 123 12 , , , cord-009561-pg4jmvw4 123 13 and and CC cord-009561-pg4jmvw4 123 14 when when WRB cord-009561-pg4jmvw4 123 15 and and CC cord-009561-pg4jmvw4 123 16 where where WRB cord-009561-pg4jmvw4 123 17 and and CC cord-009561-pg4jmvw4 123 18 how how WRB cord-009561-pg4jmvw4 123 19 to to TO cord-009561-pg4jmvw4 123 20 search search VB cord-009561-pg4jmvw4 123 21 , , , cord-009561-pg4jmvw4 123 22 is be VBZ cord-009561-pg4jmvw4 123 23 evident evident JJ cord-009561-pg4jmvw4 123 24 . . . cord-009561-pg4jmvw4 124 1 That that IN cord-009561-pg4jmvw4 124 2 the the DT cord-009561-pg4jmvw4 124 3 virus virus NN cord-009561-pg4jmvw4 124 4 has have VBZ cord-009561-pg4jmvw4 124 5 not not RB cord-009561-pg4jmvw4 124 6 been be VBN cord-009561-pg4jmvw4 124 7 identified identify VBN cord-009561-pg4jmvw4 124 8 consistently consistently RB cord-009561-pg4jmvw4 124 9 in in IN cord-009561-pg4jmvw4 124 10 multiple multiple JJ cord-009561-pg4jmvw4 124 11 sclerosis sclerosis NN cord-009561-pg4jmvw4 124 12 is be VBZ cord-009561-pg4jmvw4 124 13 certainly certainly RB cord-009561-pg4jmvw4 124 14 not not RB cord-009561-pg4jmvw4 124 15 evidence evidence NN cord-009561-pg4jmvw4 124 16 against against IN cord-009561-pg4jmvw4 124 17 the the DT cord-009561-pg4jmvw4 124 18 role role NN cord-009561-pg4jmvw4 124 19 of of IN cord-009561-pg4jmvw4 124 20 a a DT cord-009561-pg4jmvw4 124 21 virus virus NN cord-009561-pg4jmvw4 124 22 . . . cord-009561-pg4jmvw4 125 1 " " `` cord-009561-pg4jmvw4 125 2 Absence absence NN cord-009561-pg4jmvw4 125 3 of of IN cord-009561-pg4jmvw4 125 4 evidence evidence NN cord-009561-pg4jmvw4 125 5 is be VBZ cord-009561-pg4jmvw4 125 6 not not RB cord-009561-pg4jmvw4 125 7 the the DT cord-009561-pg4jmvw4 125 8 same same JJ cord-009561-pg4jmvw4 125 9 thing thing NN cord-009561-pg4jmvw4 125 10 as as IN cord-009561-pg4jmvw4 125 11 evidence evidence NN cord-009561-pg4jmvw4 125 12 of of IN cord-009561-pg4jmvw4 125 13 absence absence NN cord-009561-pg4jmvw4 125 14 " " '' cord-009561-pg4jmvw4 125 15 1877 1877 CD cord-009561-pg4jmvw4 125 16 . . . cord-009561-pg4jmvw4 125 17 _SP cord-009561-pg4jmvw4 126 1 Studies study NNS cord-009561-pg4jmvw4 126 2 on on IN cord-009561-pg4jmvw4 126 3 the the DT cord-009561-pg4jmvw4 126 4 MNral mnral JJ cord-009561-pg4jmvw4 126 5 history history NN cord-009561-pg4jmvw4 126 6 of of IN cord-009561-pg4jmvw4 126 7 multiple multiple JJ cord-009561-pg4jmvw4 126 8 sclerosis sclerosis NN cord-009561-pg4jmvw4 126 9 . . . cord-009561-pg4jmvw4 127 1 111 111 CD cord-009561-pg4jmvw4 127 2 . . . cord-009561-pg4jmvw4 128 1 Epidemiologic epidemiologic JJ cord-009561-pg4jmvw4 128 2 analysis analysis NN cord-009561-pg4jmvw4 128 3 of of IN cord-009561-pg4jmvw4 128 4 the the DT cord-009561-pg4jmvw4 128 5 Army Army NNP cord-009561-pg4jmvw4 128 6 experience experience NN cord-009561-pg4jmvw4 128 7 in in IN cord-009561-pg4jmvw4 128 8 World World NNP cord-009561-pg4jmvw4 128 9 War War NNP cord-009561-pg4jmvw4 128 10 11 11 CD cord-009561-pg4jmvw4 128 11 On on IN cord-009561-pg4jmvw4 128 12 the the DT cord-009561-pg4jmvw4 128 13 risk risk NN cord-009561-pg4jmvw4 128 14 of of IN cord-009561-pg4jmvw4 128 15 multiple multiple JJ cord-009561-pg4jmvw4 128 16 sclerosis sclerosis NN cord-009561-pg4jmvw4 128 17 according accord VBG cord-009561-pg4jmvw4 128 18 to to IN cord-009561-pg4jmvw4 128 19 age age NN cord-009561-pg4jmvw4 128 20 at at IN cord-009561-pg4jmvw4 128 21 immigration immigration NN cord-009561-pg4jmvw4 128 22 to to IN cord-009561-pg4jmvw4 128 23 South South NNP cord-009561-pg4jmvw4 128 24 Africa Africa NNP cord-009561-pg4jmvw4 128 25 Clinical clinical JJ cord-009561-pg4jmvw4 128 26 viral viral JJ cord-009561-pg4jmvw4 128 27 infections infection NNS cord-009561-pg4jmvw4 128 28 and and CC cord-009561-pg4jmvw4 129 1 multiple multiple JJ cord-009561-pg4jmvw4 129 2 sclerosis sclerosis NN cord-009561-pg4jmvw4 129 3 Viral viral JJ cord-009561-pg4jmvw4 129 4 infections infection NNS cord-009561-pg4jmvw4 129 5 trigger trigger VBP cord-009561-pg4jmvw4 129 6 multiple multiple JJ cord-009561-pg4jmvw4 129 7 sclerosis sclerosis NN cord-009561-pg4jmvw4 129 8 relapses relapse NNS cord-009561-pg4jmvw4 129 9 : : : cord-009561-pg4jmvw4 129 10 a a DT cord-009561-pg4jmvw4 129 11 prospective prospective JJ cord-009561-pg4jmvw4 129 12 seroepidemiological seroepidemiological JJ cord-009561-pg4jmvw4 129 13 study study NN cord-009561-pg4jmvw4 129 14 Simian simian JJ cord-009561-pg4jmvw4 129 15 virus virus NN cord-009561-pg4jmvw4 129 16 40 40 CD cord-009561-pg4jmvw4 129 17 ( ( -LRB- cord-009561-pg4jmvw4 129 18 SV40)-induced SV40)-induced NNP cord-009561-pg4jmvw4 129 19 disease disease NN cord-009561-pg4jmvw4 129 20 in in IN cord-009561-pg4jmvw4 129 21 rhesus rhesu NNS cord-009561-pg4jmvw4 129 22 monkeys monkey NNS cord-009561-pg4jmvw4 129 23 with with IN cord-009561-pg4jmvw4 129 24 simian simian JJ cord-009561-pg4jmvw4 129 25 acquired acquire VBN cord-009561-pg4jmvw4 129 26 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 129 27 syndrome syndrome NN cord-009561-pg4jmvw4 130 1 Resmcted resmcted JJ cord-009561-pg4jmvw4 130 2 canine canine JJ cord-009561-pg4jmvw4 130 3 distemper distemper NN cord-009561-pg4jmvw4 130 4 virus virus NN cord-009561-pg4jmvw4 130 5 infection infection NN cord-009561-pg4jmvw4 130 6 of of IN cord-009561-pg4jmvw4 130 7 ohgodendrocytes ohgodendrocyte NNS cord-009561-pg4jmvw4 130 8 Molecular Molecular NNP cord-009561-pg4jmvw4 130 9 basis basis NN cord-009561-pg4jmvw4 130 10 of of IN cord-009561-pg4jmvw4 130 11 neuropathogenicity neuropathogenicity NN cord-009561-pg4jmvw4 130 12 of of IN cord-009561-pg4jmvw4 130 13 mouse mouse NN cord-009561-pg4jmvw4 130 14 hepatitis hepatitis NNP cord-009561-pg4jmvw4 130 15 virus virus NN cord-009561-pg4jmvw4 130 16 Determinants determinant NNS cord-009561-pg4jmvw4 130 17 of of IN cord-009561-pg4jmvw4 130 18 neurological neurological JJ cord-009561-pg4jmvw4 130 19 disease disease NN cord-009561-pg4jmvw4 130 20 induced induce VBN cord-009561-pg4jmvw4 130 21 by by IN cord-009561-pg4jmvw4 130 22 Theiler Theiler NNP cord-009561-pg4jmvw4 130 23 's 's POS cord-009561-pg4jmvw4 130 24 murine murine JJ cord-009561-pg4jmvw4 130 25 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 130 26 virus virus NN cord-009561-pg4jmvw4 130 27 Treatment Treatment NNP cord-009561-pg4jmvw4 130 28 of of IN cord-009561-pg4jmvw4 130 29 encephalomyocarditis encephalomyocarditis NNP cord-009561-pg4jmvw4 130 30 virus virus NN cord-009561-pg4jmvw4 130 31 - - HYPH cord-009561-pg4jmvw4 130 32 induced induce VBN cord-009561-pg4jmvw4 130 33 central central JJ cord-009561-pg4jmvw4 130 34 nervous nervous JJ cord-009561-pg4jmvw4 130 35 system system NN cord-009561-pg4jmvw4 130 36 demyelination demyelination NN cord-009561-pg4jmvw4 130 37 with with IN cord-009561-pg4jmvw4 130 38 monoclonal monoclonal JJ cord-009561-pg4jmvw4 130 39 anti anti JJ cord-009561-pg4jmvw4 130 40 - - JJ cord-009561-pg4jmvw4 130 41 T t JJ cord-009561-pg4jmvw4 130 42 - - HYPH cord-009561-pg4jmvw4 130 43 cell cell NN cord-009561-pg4jmvw4 130 44 antibodies antibody NNS cord-009561-pg4jmvw4 131 1 Semliki Semliki NNP cord-009561-pg4jmvw4 131 2 forest forest NN cord-009561-pg4jmvw4 131 3 virus virus NN cord-009561-pg4jmvw4 131 4 - - HYPH cord-009561-pg4jmvw4 131 5 induced induce VBN cord-009561-pg4jmvw4 131 6 , , , cord-009561-pg4jmvw4 131 7 immune immune NN cord-009561-pg4jmvw4 131 8 - - HYPH cord-009561-pg4jmvw4 131 9 mediated mediate VBN cord-009561-pg4jmvw4 131 10 demyelination demyelination NN cord-009561-pg4jmvw4 131 11 : : : cord-009561-pg4jmvw4 131 12 adoptive adoptive JJ cord-009561-pg4jmvw4 131 13 transfer transfer NN cord-009561-pg4jmvw4 131 14 studies study NNS cord-009561-pg4jmvw4 131 15 and and CC cord-009561-pg4jmvw4 131 16 viral viral JJ cord-009561-pg4jmvw4 131 17 persistence persistence NN cord-009561-pg4jmvw4 131 18 in in IN cord-009561-pg4jmvw4 131 19 nude nude JJ cord-009561-pg4jmvw4 131 20 mice mouse NNS cord-009561-pg4jmvw4 131 21 Ross Ross NNP cord-009561-pg4jmvw4 131 22 river river NN cord-009561-pg4jmvw4 131 23 virus virus NN cord-009561-pg4jmvw4 131 24 - - HYPH cord-009561-pg4jmvw4 131 25 induced induce VBN cord-009561-pg4jmvw4 131 26 demyelination demyelination NN cord-009561-pg4jmvw4 131 27 : : : cord-009561-pg4jmvw4 131 28 1 1 LS cord-009561-pg4jmvw4 131 29 . . . cord-009561-pg4jmvw4 131 30 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 131 31 and and CC cord-009561-pg4jmvw4 131 32 histopathology histopathology NN cord-009561-pg4jmvw4 131 33 Virus virus NN cord-009561-pg4jmvw4 131 34 - - HYPH cord-009561-pg4jmvw4 131 35 induced induce VBN cord-009561-pg4jmvw4 131 36 demyelination demyelination NN cord-009561-pg4jmvw4 131 37 . . . cord-009561-pg4jmvw4 132 1 Production production NN cord-009561-pg4jmvw4 132 2 by by IN cord-009561-pg4jmvw4 132 3 a a DT cord-009561-pg4jmvw4 132 4 viral viral JJ cord-009561-pg4jmvw4 132 5 temperature temperature NN cord-009561-pg4jmvw4 132 6 sensitive sensitive JJ cord-009561-pg4jmvw4 132 7 mutant mutant JJ cord-009561-pg4jmvw4 132 8 Biology biology NN cord-009561-pg4jmvw4 132 9 and and CC cord-009561-pg4jmvw4 132 10 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 132 11 of of IN cord-009561-pg4jmvw4 132 12 lentiviruses lentiviruse NNS cord-009561-pg4jmvw4 132 13 Measles Measles NNP cord-009561-pg4jmvw4 132 14 antibodies antibody NNS cord-009561-pg4jmvw4 132 15 in in IN cord-009561-pg4jmvw4 132 16 multiple multiple JJ cord-009561-pg4jmvw4 132 17 sclerosis sclerosis NN cord-009561-pg4jmvw4 132 18 Epstein Epstein NNP cord-009561-pg4jmvw4 132 19 - - HYPH cord-009561-pg4jmvw4 132 20 Barr Barr NNP cord-009561-pg4jmvw4 132 21 virus virus NN cord-009561-pg4jmvw4 132 22 infection infection NN cord-009561-pg4jmvw4 132 23 and and CC cord-009561-pg4jmvw4 132 24 antibody antibody NN cord-009561-pg4jmvw4 132 25 synthesis synthesis NN cord-009561-pg4jmvw4 132 26 in in IN cord-009561-pg4jmvw4 132 27 patients patient NNS cord-009561-pg4jmvw4 132 28 with with IN cord-009561-pg4jmvw4 132 29 multiple multiple JJ cord-009561-pg4jmvw4 132 30 sclerosis sclerosis NN cord-009561-pg4jmvw4 132 31 Viral viral JJ cord-009561-pg4jmvw4 132 32 antibodies antibody NNS cord-009561-pg4jmvw4 132 33 in in IN cord-009561-pg4jmvw4 132 34 multiple multiple JJ cord-009561-pg4jmvw4 132 35 sclerosis sclerosis NN cord-009561-pg4jmvw4 132 36 Intrathecal Intrathecal NNP cord-009561-pg4jmvw4 132 37 antibody antibody NN cord-009561-pg4jmvw4 132 38 synthesis synthesis NN cord-009561-pg4jmvw4 132 39 to to IN cord-009561-pg4jmvw4 132 40 virus virus NN cord-009561-pg4jmvw4 132 41 antigens antigen NNS cord-009561-pg4jmvw4 132 42 in in IN cord-009561-pg4jmvw4 132 43 multiple multiple JJ cord-009561-pg4jmvw4 132 44 sclerosis sclerosis NN cord-009561-pg4jmvw4 132 45 Sera Sera NNP cord-009561-pg4jmvw4 132 46 from from IN cord-009561-pg4jmvw4 132 47 patients patient NNS cord-009561-pg4jmvw4 132 48 with with IN cord-009561-pg4jmvw4 132 49 multiple multiple JJ cord-009561-pg4jmvw4 132 50 sclerosis sclerosis NN cord-009561-pg4jmvw4 132 51 react react VB cord-009561-pg4jmvw4 132 52 with with IN cord-009561-pg4jmvw4 132 53 human human JJ cord-009561-pg4jmvw4 132 54 T T NNP cord-009561-pg4jmvw4 132 55 cell cell NN cord-009561-pg4jmvw4 132 56 lymphouopic lymphouopic NNP cord-009561-pg4jmvw4 132 57 virus virus NN cord-009561-pg4jmvw4 132 58 - - : cord-009561-pg4jmvw4 132 59 I -PRON- PRP cord-009561-pg4jmvw4 132 60 gag gag VBP cord-009561-pg4jmvw4 132 61 proteins protein NNS cord-009561-pg4jmvw4 132 62 but but CC cord-009561-pg4jmvw4 132 63 not not RB cord-009561-pg4jmvw4 132 64 env env NN cord-009561-pg4jmvw4 132 65 proteins protein NNS cord-009561-pg4jmvw4 132 66 - - : cord-009561-pg4jmvw4 132 67 westem westem NN cord-009561-pg4jmvw4 132 68 blotting blotting NN cord-009561-pg4jmvw4 132 69 analysis analysis NN cord-009561-pg4jmvw4 132 70 Antibodies Antibodies NNPS cord-009561-pg4jmvw4 132 71 against against IN cord-009561-pg4jmvw4 132 72 the the DT cord-009561-pg4jmvw4 132 73 paramyxovirus paramyxovirus JJ cord-009561-pg4jmvw4 132 74 SV5 SV5 NNP cord-009561-pg4jmvw4 132 75 in in IN cord-009561-pg4jmvw4 132 76 the the DT cord-009561-pg4jmvw4 132 77 cerebrospinal cerebrospinal JJ cord-009561-pg4jmvw4 132 78 fluids fluid NNS cord-009561-pg4jmvw4 132 79 of of IN cord-009561-pg4jmvw4 132 80 some some DT cord-009561-pg4jmvw4 132 81 multiple multiple JJ cord-009561-pg4jmvw4 132 82 sclerosis sclerosis NN cord-009561-pg4jmvw4 132 83 patients patient NNS cord-009561-pg4jmvw4 133 1 Progressive progressive JJ cord-009561-pg4jmvw4 133 2 multifocal multifocal JJ cord-009561-pg4jmvw4 133 3 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 133 4 Progressive progressive JJ cord-009561-pg4jmvw4 133 5 multifocal multifocal JJ cord-009561-pg4jmvw4 133 6 leukoencephaloparhy leukoencephaloparhy NN cord-009561-pg4jmvw4 133 7 : : : cord-009561-pg4jmvw4 133 8 a a DT cord-009561-pg4jmvw4 133 9 burnt burn VBN cord-009561-pg4jmvw4 133 10 - - HYPH cord-009561-pg4jmvw4 133 11 out out RP cord-009561-pg4jmvw4 133 12 case case NN cord-009561-pg4jmvw4 133 13 Prolonged prolong VBN cord-009561-pg4jmvw4 133 14 survival survival NN cord-009561-pg4jmvw4 133 15 and and CC cord-009561-pg4jmvw4 133 16 partial partial JJ cord-009561-pg4jmvw4 133 17 recovery recovery NN cord-009561-pg4jmvw4 133 18 in in IN cord-009561-pg4jmvw4 133 19 AIDS AIDS NNP cord-009561-pg4jmvw4 133 20 - - HYPH cord-009561-pg4jmvw4 133 21 associated associate VBN cord-009561-pg4jmvw4 133 22 progressive progressive JJ cord-009561-pg4jmvw4 133 23 multifocal multifocal JJ cord-009561-pg4jmvw4 133 24 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 133 25 Progressive progressive JJ cord-009561-pg4jmvw4 133 26 multifocal multifocal JJ cord-009561-pg4jmvw4 133 27 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 133 28 Particles particle NNS cord-009561-pg4jmvw4 133 29 resembling resemble VBG cord-009561-pg4jmvw4 133 30 papovavirus papovavirus NNP cord-009561-pg4jmvw4 133 31 in in IN cord-009561-pg4jmvw4 133 32 human human JJ cord-009561-pg4jmvw4 133 33 cerebral cerebral JJ cord-009561-pg4jmvw4 133 34 demyelinating demyelinate VBG cord-009561-pg4jmvw4 133 35 disease disease NN cord-009561-pg4jmvw4 133 36 pova pova NN cord-009561-pg4jmvw4 133 37 - - HYPH cord-009561-pg4jmvw4 133 38 like like JJ cord-009561-pg4jmvw4 133 39 virus virus NN cord-009561-pg4jmvw4 133 40 from from IN cord-009561-pg4jmvw4 133 41 human human JJ cord-009561-pg4jmvw4 133 42 brain brain NN cord-009561-pg4jmvw4 133 43 with with IN cord-009561-pg4jmvw4 133 44 progressive progressive JJ cord-009561-pg4jmvw4 133 45 multifocal multifocal JJ cord-009561-pg4jmvw4 133 46 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 133 47 Papovavirus Papovavirus NNP cord-009561-pg4jmvw4 133 48 of of IN cord-009561-pg4jmvw4 133 49 JC JC NNP cord-009561-pg4jmvw4 133 50 type type NN cord-009561-pg4jmvw4 133 51 in in IN cord-009561-pg4jmvw4 133 52 progressive progressive JJ cord-009561-pg4jmvw4 133 53 multifocal multifocal JJ cord-009561-pg4jmvw4 133 54 leukoencephalopathy leukoencephalopathy NNP cord-009561-pg4jmvw4 133 55 Etiology etiology NN cord-009561-pg4jmvw4 133 56 of of IN cord-009561-pg4jmvw4 133 57 progressive progressive JJ cord-009561-pg4jmvw4 133 58 multifocal multifocal JJ cord-009561-pg4jmvw4 133 59 leukoencephalopathy leukoencephalopathy NN cord-009561-pg4jmvw4 133 60 - - HYPH cord-009561-pg4jmvw4 133 61 identification identification NN cord-009561-pg4jmvw4 133 62 of of IN cord-009561-pg4jmvw4 133 63 papovavirus papovavirus JJ cord-009561-pg4jmvw4 133 64 Progressive progressive JJ cord-009561-pg4jmvw4 133 65 multifocal multifocal JJ cord-009561-pg4jmvw4 133 66 leukoencephalopathy leukoencephalopathy NNS cord-009561-pg4jmvw4 133 67 : : : cord-009561-pg4jmvw4 133 68 JC JC NNP cord-009561-pg4jmvw4 133 69 virus virus NN cord-009561-pg4jmvw4 133 70 detection detection NN cord-009561-pg4jmvw4 133 71 by by IN cord-009561-pg4jmvw4 133 72 in in IN cord-009561-pg4jmvw4 133 73 situ situ NN cord-009561-pg4jmvw4 133 74 hybridization hybridization NN cord-009561-pg4jmvw4 133 75 compared compare VBN cord-009561-pg4jmvw4 133 76 with with IN cord-009561-pg4jmvw4 133 77 immunohistochemisuy immunohistochemisuy NNP cord-009561-pg4jmvw4 133 78 Slow slow JJ cord-009561-pg4jmvw4 133 79 virus virus NN cord-009561-pg4jmvw4 133 80 infections infection NNS cord-009561-pg4jmvw4 133 81 of of IN cord-009561-pg4jmvw4 133 82 rhe rhe JJ cord-009561-pg4jmvw4 133 83 central central JJ cord-009561-pg4jmvw4 133 84 nervous nervous JJ cord-009561-pg4jmvw4 133 85 system system NN cord-009561-pg4jmvw4 133 86 Postinfectious Postinfectious NNP cord-009561-pg4jmvw4 133 87 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 133 88 Postinfectious Postinfectious NNP cord-009561-pg4jmvw4 133 89 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 134 1 A a DT cord-009561-pg4jmvw4 134 2 quantitation quantitation NN cord-009561-pg4jmvw4 134 3 of of IN cord-009561-pg4jmvw4 134 4 myelin myelin NN cord-009561-pg4jmvw4 134 5 - - HYPH cord-009561-pg4jmvw4 134 6 associated associate VBN cord-009561-pg4jmvw4 134 7 glycoprotein glycoprotein NN cord-009561-pg4jmvw4 134 8 and and CC cord-009561-pg4jmvw4 134 9 myelin myelin JJ cord-009561-pg4jmvw4 134 10 basic basic JJ cord-009561-pg4jmvw4 134 11 protein protein NN cord-009561-pg4jmvw4 134 12 loss loss NN cord-009561-pg4jmvw4 134 13 in in IN cord-009561-pg4jmvw4 134 14 different different JJ cord-009561-pg4jmvw4 134 15 demyelinating demyelinating JJ cord-009561-pg4jmvw4 134 16 diseases disease NNS cord-009561-pg4jmvw4 134 17 Measles measles NN cord-009561-pg4jmvw4 134 18 : : : cord-009561-pg4jmvw4 134 19 summary summary NN cord-009561-pg4jmvw4 134 20 of of IN cord-009561-pg4jmvw4 134 21 worldwide worldwide JJ cord-009561-pg4jmvw4 134 22 impact impact NN cord-009561-pg4jmvw4 134 23 Das Das NNP cord-009561-pg4jmvw4 134 24 verhalten verhalten NNP cord-009561-pg4jmvw4 134 25 der der NNP cord-009561-pg4jmvw4 134 26 kutanen kutanen NNP cord-009561-pg4jmvw4 134 27 tuberkulin tuberkulin NNP cord-009561-pg4jmvw4 134 28 - - HYPH cord-009561-pg4jmvw4 134 29 reaktion reaktion NNP cord-009561-pg4jmvw4 134 30 wahrend wahrend NN cord-009561-pg4jmvw4 134 31 der der NNP cord-009561-pg4jmvw4 134 32 Masern Masern NNP cord-009561-pg4jmvw4 134 33 Cellular Cellular NNP cord-009561-pg4jmvw4 134 34 immune immune JJ cord-009561-pg4jmvw4 134 35 responses response NNS cord-009561-pg4jmvw4 134 36 during during IN cord-009561-pg4jmvw4 134 37 complicated complicated JJ cord-009561-pg4jmvw4 134 38 and and CC cord-009561-pg4jmvw4 134 39 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 134 40 measles measle NNS cord-009561-pg4jmvw4 134 41 virus virus NN cord-009561-pg4jmvw4 134 42 infections infection NNS cord-009561-pg4jmvw4 134 43 of of IN cord-009561-pg4jmvw4 134 44 man man NN cord-009561-pg4jmvw4 134 45 Peripheral peripheral JJ cord-009561-pg4jmvw4 134 46 blood blood NN cord-009561-pg4jmvw4 134 47 mononuclear mononuclear NN cord-009561-pg4jmvw4 134 48 cells cell NNS cord-009561-pg4jmvw4 134 49 during during IN cord-009561-pg4jmvw4 134 50 nacural nacural JJ cord-009561-pg4jmvw4 134 51 measles measles NNP cord-009561-pg4jmvw4 134 52 virus virus NN cord-009561-pg4jmvw4 134 53 infection infection NN cord-009561-pg4jmvw4 134 54 : : : cord-009561-pg4jmvw4 134 55 cell cell NN cord-009561-pg4jmvw4 134 56 surface surface NN cord-009561-pg4jmvw4 134 57 phenotypes phenotype NNS cord-009561-pg4jmvw4 134 58 and and CC cord-009561-pg4jmvw4 134 59 evidence evidence NN cord-009561-pg4jmvw4 134 60 for for IN cord-009561-pg4jmvw4 134 61 activation activation NN cord-009561-pg4jmvw4 134 62 Prospective prospective JJ cord-009561-pg4jmvw4 134 63 study study NN cord-009561-pg4jmvw4 134 64 of of IN cord-009561-pg4jmvw4 134 65 the the DT cord-009561-pg4jmvw4 134 66 magnitude magnitude NN cord-009561-pg4jmvw4 134 67 and and CC cord-009561-pg4jmvw4 134 68 duration duration NN cord-009561-pg4jmvw4 134 69 of of IN cord-009561-pg4jmvw4 134 70 changes change NNS cord-009561-pg4jmvw4 134 71 in in IN cord-009561-pg4jmvw4 134 72 tuberculin tuberculin NN cord-009561-pg4jmvw4 134 73 reactivity reactivity NN cord-009561-pg4jmvw4 134 74 during during IN cord-009561-pg4jmvw4 134 75 complicated complicated JJ cord-009561-pg4jmvw4 134 76 and and CC cord-009561-pg4jmvw4 134 77 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 134 78 measles measle NNS cord-009561-pg4jmvw4 134 79 Development Development NNP cord-009561-pg4jmvw4 134 80 of of IN cord-009561-pg4jmvw4 134 81 antibody antibody NN cord-009561-pg4jmvw4 134 82 to to IN cord-009561-pg4jmvw4 134 83 measles measles NN cord-009561-pg4jmvw4 134 84 virus virus NN cord-009561-pg4jmvw4 134 85 polypeptides polypeptide NNS cord-009561-pg4jmvw4 134 86 during during IN cord-009561-pg4jmvw4 134 87 complicated complicated JJ cord-009561-pg4jmvw4 134 88 and and CC cord-009561-pg4jmvw4 134 89 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 134 90 measles measle NNS cord-009561-pg4jmvw4 134 91 virus virus NN cord-009561-pg4jmvw4 134 92 infections infection NNS cord-009561-pg4jmvw4 134 93 Immune immune VBP cord-009561-pg4jmvw4 134 94 activation activation NN cord-009561-pg4jmvw4 134 95 during during IN cord-009561-pg4jmvw4 134 96 measles measle NNS cord-009561-pg4jmvw4 134 97 Spontaneous spontaneous JJ cord-009561-pg4jmvw4 134 98 proliferation proliferation NN cord-009561-pg4jmvw4 134 99 of of IN cord-009561-pg4jmvw4 134 100 peripheral peripheral JJ cord-009561-pg4jmvw4 134 101 mononuclear mononuclear JJ cord-009561-pg4jmvw4 134 102 cells cell NNS cord-009561-pg4jmvw4 134 103 in in IN cord-009561-pg4jmvw4 134 104 natural natural JJ cord-009561-pg4jmvw4 134 105 measles measle NNS cord-009561-pg4jmvw4 134 106 virus virus NN cord-009561-pg4jmvw4 134 107 infection infection NN cord-009561-pg4jmvw4 134 108 : : : cord-009561-pg4jmvw4 134 109 identification identification NN cord-009561-pg4jmvw4 134 110 of of IN cord-009561-pg4jmvw4 134 111 dividing divide VBG cord-009561-pg4jmvw4 134 112 cells cell NNS cord-009561-pg4jmvw4 134 113 and and CC cord-009561-pg4jmvw4 134 114 correlation correlation NN cord-009561-pg4jmvw4 134 115 with with IN cord-009561-pg4jmvw4 134 116 mitogen mitogen NN cord-009561-pg4jmvw4 134 117 responsiveness responsiveness NN cord-009561-pg4jmvw4 134 118 Changes change NNS cord-009561-pg4jmvw4 134 119 in in IN cord-009561-pg4jmvw4 134 120 plasma plasma NN cord-009561-pg4jmvw4 134 121 IgE IgE NNP cord-009561-pg4jmvw4 134 122 levels level NNS cord-009561-pg4jmvw4 134 123 during during IN cord-009561-pg4jmvw4 134 124 complicated complicated JJ cord-009561-pg4jmvw4 134 125 and and CC cord-009561-pg4jmvw4 134 126 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 134 127 measles measle NNS cord-009561-pg4jmvw4 134 128 virus virus NN cord-009561-pg4jmvw4 134 129 infections infection NNS cord-009561-pg4jmvw4 134 130 Changes change NNS cord-009561-pg4jmvw4 134 131 in in IN cord-009561-pg4jmvw4 134 132 serum serum NN cord-009561-pg4jmvw4 134 133 C c NN cord-009561-pg4jmvw4 134 134 - - HYPH cord-009561-pg4jmvw4 134 135 reactive reactive JJ cord-009561-pg4jmvw4 134 136 protein protein NN cord-009561-pg4jmvw4 134 137 during during IN cord-009561-pg4jmvw4 134 138 complicated complicated JJ cord-009561-pg4jmvw4 134 139 and and CC cord-009561-pg4jmvw4 134 140 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 134 141 measles measle NNS cord-009561-pg4jmvw4 134 142 virus virus NN cord-009561-pg4jmvw4 134 143 infections infection NNS cord-009561-pg4jmvw4 134 144 Immune immune VBP cord-009561-pg4jmvw4 134 145 activation activation NN cord-009561-pg4jmvw4 134 146 during during IN cord-009561-pg4jmvw4 134 147 measles measle NNS cord-009561-pg4jmvw4 134 148 . . . cord-009561-pg4jmvw4 135 1 p-2 p-2 NNP cord-009561-pg4jmvw4 135 2 microglobulin microglobulin NN cord-009561-pg4jmvw4 135 3 in in IN cord-009561-pg4jmvw4 135 4 plasma plasma NN cord-009561-pg4jmvw4 135 5 and and CC cord-009561-pg4jmvw4 135 6 cerebrospinal cerebrospinal JJ cord-009561-pg4jmvw4 135 7 fluid fluid NN cord-009561-pg4jmvw4 135 8 in in IN cord-009561-pg4jmvw4 135 9 complicated complicated JJ cord-009561-pg4jmvw4 135 10 disease disease NN cord-009561-pg4jmvw4 135 11 Cytokine cytokine NN cord-009561-pg4jmvw4 135 12 production production NN cord-009561-pg4jmvw4 135 13 in in IN cord-009561-pg4jmvw4 135 14 vitro vitro FW cord-009561-pg4jmvw4 135 15 and and CC cord-009561-pg4jmvw4 135 16 the the DT cord-009561-pg4jmvw4 135 17 lymphoproliferative lymphoproliferative JJ cord-009561-pg4jmvw4 135 18 defect defect NN cord-009561-pg4jmvw4 135 19 of of IN cord-009561-pg4jmvw4 135 20 natural natural JJ cord-009561-pg4jmvw4 135 21 measles measle NNS cord-009561-pg4jmvw4 135 22 virus virus NN cord-009561-pg4jmvw4 135 23 infection infection NN cord-009561-pg4jmvw4 135 24 Measles Measles NNP cord-009561-pg4jmvw4 135 25 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 135 26 : : : cord-009561-pg4jmvw4 135 27 clinical clinical JJ cord-009561-pg4jmvw4 135 28 and and CC cord-009561-pg4jmvw4 135 29 immunological immunological JJ cord-009561-pg4jmvw4 135 30 studies study NNS cord-009561-pg4jmvw4 135 31 Dulac Dulac NNP cord-009561-pg4jmvw4 135 32 0 0 CD cord-009561-pg4jmvw4 135 33 , , , cord-009561-pg4jmvw4 135 34 et et NNP cord-009561-pg4jmvw4 135 35 al al NNP cord-009561-pg4jmvw4 135 36 . . . cord-009561-pg4jmvw4 136 1 Interferon interferon NN cord-009561-pg4jmvw4 136 2 - - HYPH cord-009561-pg4jmvw4 136 3 r r NN cord-009561-pg4jmvw4 136 4 in in IN cord-009561-pg4jmvw4 137 1 acute acute JJ cord-009561-pg4jmvw4 137 2 and and CC cord-009561-pg4jmvw4 137 3 subacute subacute JJ cord-009561-pg4jmvw4 137 4 encephalitis encephalitis NN cord-009561-pg4jmvw4 137 5 Johnson Johnson NNP cord-009561-pg4jmvw4 137 6 : : : cord-009561-pg4jmvw4 137 7 Virology virology NN cord-009561-pg4jmvw4 137 8 of of IN cord-009561-pg4jmvw4 137 9 Demyelinating Demyelinating NNP cord-009561-pg4jmvw4 137 10 Diseases Diseases NNPS cord-009561-pg4jmvw4 137 11 S59 S59 NNP cord-009561-pg4jmvw4 137 12 Immune Immune NNP cord-009561-pg4jmvw4 137 13 activation activation NN cord-009561-pg4jmvw4 137 14 during during IN cord-009561-pg4jmvw4 137 15 measles measle NNS cord-009561-pg4jmvw4 137 16 : : : cord-009561-pg4jmvw4 137 17 P2-microglobulin P2-microglobulin NNP cord-009561-pg4jmvw4 137 18 in in IN cord-009561-pg4jmvw4 137 19 plasma plasma NN cord-009561-pg4jmvw4 137 20 and and CC cord-009561-pg4jmvw4 137 21 cerebrospinal cerebrospinal JJ cord-009561-pg4jmvw4 137 22 fluid fluid NN cord-009561-pg4jmvw4 137 23 in in IN cord-009561-pg4jmvw4 137 24 complicated complicated JJ cord-009561-pg4jmvw4 137 25 and and CC cord-009561-pg4jmvw4 137 26 uncomplicated uncomplicated JJ cord-009561-pg4jmvw4 137 27 disease disease NN cord-009561-pg4jmvw4 137 28 Distribution distribution NN cord-009561-pg4jmvw4 137 29 of of IN cord-009561-pg4jmvw4 137 30 measles measle NNS cord-009561-pg4jmvw4 137 31 virus virus NN cord-009561-pg4jmvw4 137 32 antigen antigen NNP cord-009561-pg4jmvw4 137 33 and and CC cord-009561-pg4jmvw4 137 34 RNA RNA NNP cord-009561-pg4jmvw4 137 35 in in IN cord-009561-pg4jmvw4 137 36 acute acute JJ cord-009561-pg4jmvw4 137 37 measles measle NNS cord-009561-pg4jmvw4 137 38 with with IN cord-009561-pg4jmvw4 137 39 and and CC cord-009561-pg4jmvw4 137 40 without without IN cord-009561-pg4jmvw4 137 41 neurologic neurologic JJ cord-009561-pg4jmvw4 137 42 involvement involvement NN cord-009561-pg4jmvw4 137 43 Infection infection NN cord-009561-pg4jmvw4 137 44 of of IN cord-009561-pg4jmvw4 137 45 monocytes monocyte NNS cord-009561-pg4jmvw4 137 46 during during IN cord-009561-pg4jmvw4 137 47 measles measle NNS cord-009561-pg4jmvw4 137 48 Pneumocystis Pneumocystis NNP cord-009561-pg4jmvw4 137 49 pneumonia pneumonia NN cord-009561-pg4jmvw4 137 50 - - HYPH cord-009561-pg4jmvw4 137 51 hs hs NNP cord-009561-pg4jmvw4 137 52 Angeles Angeles NNP cord-009561-pg4jmvw4 137 53 Kaposi Kaposi NNP cord-009561-pg4jmvw4 137 54 's 's POS cord-009561-pg4jmvw4 137 55 sarcoma sarcoma NN cord-009561-pg4jmvw4 137 56 and and CC cord-009561-pg4jmvw4 137 57 Pneumocystis Pneumocystis NNP cord-009561-pg4jmvw4 137 58 pneumonia pneumonia NN cord-009561-pg4jmvw4 137 59 among among IN cord-009561-pg4jmvw4 137 60 homosexual homosexual JJ cord-009561-pg4jmvw4 137 61 men man NNS cord-009561-pg4jmvw4 137 62 Isolation isolation NN cord-009561-pg4jmvw4 137 63 of of IN cord-009561-pg4jmvw4 137 64 HTLV-111 HTLV-111 NNP cord-009561-pg4jmvw4 137 65 from from IN cord-009561-pg4jmvw4 137 66 cerebrospinal cerebrospinal JJ cord-009561-pg4jmvw4 137 67 fluid fluid NN cord-009561-pg4jmvw4 137 68 and and CC cord-009561-pg4jmvw4 137 69 neural neural JJ cord-009561-pg4jmvw4 137 70 tissues tissue NNS cord-009561-pg4jmvw4 137 71 of of IN cord-009561-pg4jmvw4 137 72 patients patient NNS cord-009561-pg4jmvw4 137 73 with with IN cord-009561-pg4jmvw4 137 74 neurologic neurologic JJ cord-009561-pg4jmvw4 137 75 syndromes syndrome NNS cord-009561-pg4jmvw4 137 76 related relate VBN cord-009561-pg4jmvw4 137 77 to to IN cord-009561-pg4jmvw4 137 78 the the DT cord-009561-pg4jmvw4 137 79 acquired acquire VBN cord-009561-pg4jmvw4 137 80 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 137 81 syndrome syndrome NN cord-009561-pg4jmvw4 137 82 Isolation isolation NN cord-009561-pg4jmvw4 137 83 of of IN cord-009561-pg4jmvw4 137 84 AIDSassociated aidsassociate VBN cord-009561-pg4jmvw4 137 85 retroviruses retrovirus NNS cord-009561-pg4jmvw4 137 86 from from IN cord-009561-pg4jmvw4 137 87 cerebrospinal cerebrospinal JJ cord-009561-pg4jmvw4 137 88 fluid fluid NN cord-009561-pg4jmvw4 137 89 and and CC cord-009561-pg4jmvw4 137 90 brain brain NN cord-009561-pg4jmvw4 137 91 of of IN cord-009561-pg4jmvw4 137 92 patients patient NNS cord-009561-pg4jmvw4 137 93 with with IN cord-009561-pg4jmvw4 137 94 neurological neurological JJ cord-009561-pg4jmvw4 137 95 symptoms symptom NNS cord-009561-pg4jmvw4 137 96 HTLV-111 htlv-111 JJ cord-009561-pg4jmvw4 137 97 infection infection NN cord-009561-pg4jmvw4 137 98 in in IN cord-009561-pg4jmvw4 137 99 brains brain NNS cord-009561-pg4jmvw4 137 100 of of IN cord-009561-pg4jmvw4 137 101 children child NNS cord-009561-pg4jmvw4 137 102 and and CC cord-009561-pg4jmvw4 137 103 adults adult NNS cord-009561-pg4jmvw4 137 104 with with IN cord-009561-pg4jmvw4 137 105 Intrablood Intrablood NNP cord-009561-pg4jmvw4 137 106 - - HYPH cord-009561-pg4jmvw4 137 107 brain brain NN cord-009561-pg4jmvw4 137 108 - - HYPH cord-009561-pg4jmvw4 137 109 barrier barrier NN cord-009561-pg4jmvw4 137 110 synthesis synthesis NN cord-009561-pg4jmvw4 137 111 of of IN cord-009561-pg4jmvw4 137 112 HTLV-111-specific HTLV-111-specific NNP cord-009561-pg4jmvw4 137 113 IgG igg NN cord-009561-pg4jmvw4 137 114 in in IN cord-009561-pg4jmvw4 137 115 patients patient NNS cord-009561-pg4jmvw4 137 116 with with IN cord-009561-pg4jmvw4 137 117 neurologic neurologic JJ cord-009561-pg4jmvw4 137 118 symptoms symptom NNS cord-009561-pg4jmvw4 137 119 associated associate VBN cord-009561-pg4jmvw4 137 120 with with IN cord-009561-pg4jmvw4 137 121 AIDS AIDS NNP cord-009561-pg4jmvw4 137 122 or or CC cord-009561-pg4jmvw4 137 123 AIDS AIDS NNP cord-009561-pg4jmvw4 137 124 - - HYPH cord-009561-pg4jmvw4 137 125 related relate VBN cord-009561-pg4jmvw4 137 126 complex complex JJ cord-009561-pg4jmvw4 137 127 Sequence sequence NN cord-009561-pg4jmvw4 137 128 homology homology NN cord-009561-pg4jmvw4 137 129 and and CC cord-009561-pg4jmvw4 137 130 morphologic morphologic JJ cord-009561-pg4jmvw4 137 131 similarity similarity NN cord-009561-pg4jmvw4 137 132 of of IN cord-009561-pg4jmvw4 137 133 HTLV HTLV NNP cord-009561-pg4jmvw4 137 134 - - HYPH cord-009561-pg4jmvw4 137 135 I11 I11 NNP cord-009561-pg4jmvw4 137 136 and and CC cord-009561-pg4jmvw4 137 137 visna visna NNP cord-009561-pg4jmvw4 137 138 virus virus NN cord-009561-pg4jmvw4 137 139 , , , cord-009561-pg4jmvw4 137 140 a a DT cord-009561-pg4jmvw4 137 141 pathogenic pathogenic JJ cord-009561-pg4jmvw4 137 142 lentivirus lentivirus NN cord-009561-pg4jmvw4 137 143 Neurologic neurologic JJ cord-009561-pg4jmvw4 137 144 manifestations manifestation NNS cord-009561-pg4jmvw4 137 145 of of IN cord-009561-pg4jmvw4 137 146 AIDS AIDS NNP cord-009561-pg4jmvw4 138 1 The the DT cord-009561-pg4jmvw4 138 2 neurobiology neurobiology NN cord-009561-pg4jmvw4 138 3 of of IN cord-009561-pg4jmvw4 138 4 human human JJ cord-009561-pg4jmvw4 138 5 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 138 6 virus virus NN cord-009561-pg4jmvw4 138 7 infections infection NNS cord-009561-pg4jmvw4 139 1 The the DT cord-009561-pg4jmvw4 139 2 AIDS AIDS NNP cord-009561-pg4jmvw4 139 3 dementia dementia NN cord-009561-pg4jmvw4 139 4 complex complex NN cord-009561-pg4jmvw4 139 5 : : : cord-009561-pg4jmvw4 140 1 11 11 CD cord-009561-pg4jmvw4 140 2 Vacuolar Vacuolar NNP cord-009561-pg4jmvw4 140 3 myelopathy myelopathy NN cord-009561-pg4jmvw4 140 4 pathologically pathologically RB cord-009561-pg4jmvw4 140 5 resembling resemble VBG cord-009561-pg4jmvw4 140 6 subacute subacute JJ cord-009561-pg4jmvw4 140 7 combined combine VBN cord-009561-pg4jmvw4 140 8 degeneration degeneration NN cord-009561-pg4jmvw4 140 9 in in IN cord-009561-pg4jmvw4 140 10 patients patient NNS cord-009561-pg4jmvw4 140 11 with with IN cord-009561-pg4jmvw4 140 12 the the DT cord-009561-pg4jmvw4 140 13 acquired acquire VBN cord-009561-pg4jmvw4 140 14 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 140 15 syndrome syndrome NN cord-009561-pg4jmvw4 140 16 Morphological morphological JJ cord-009561-pg4jmvw4 140 17 spectrum spectrum NN cord-009561-pg4jmvw4 140 18 , , , cord-009561-pg4jmvw4 140 19 distribution distribution NN cord-009561-pg4jmvw4 140 20 and and CC cord-009561-pg4jmvw4 140 21 clinical clinical JJ cord-009561-pg4jmvw4 140 22 correlation correlation NN cord-009561-pg4jmvw4 140 23 of of IN cord-009561-pg4jmvw4 140 24 white white JJ cord-009561-pg4jmvw4 140 25 matter matter NN cord-009561-pg4jmvw4 140 26 lesions lesion NNS cord-009561-pg4jmvw4 140 27 in in IN cord-009561-pg4jmvw4 140 28 AIDS AIDS NNP cord-009561-pg4jmvw4 140 29 brains brain NNS cord-009561-pg4jmvw4 141 1 Cerebral cerebral JJ cord-009561-pg4jmvw4 141 2 white white JJ cord-009561-pg4jmvw4 141 3 matter matter NN cord-009561-pg4jmvw4 141 4 changes change NNS cord-009561-pg4jmvw4 141 5 in in IN cord-009561-pg4jmvw4 141 6 acquired acquire VBN cord-009561-pg4jmvw4 141 7 immunodeficiency immunodeficiency NNP cord-009561-pg4jmvw4 141 8 syndrome syndrome NN cord-009561-pg4jmvw4 141 9 dementia dementia NN cord-009561-pg4jmvw4 141 10 : : : cord-009561-pg4jmvw4 141 11 alterations alteration NNS cord-009561-pg4jmvw4 141 12 of of IN cord-009561-pg4jmvw4 141 13 the the DT cord-009561-pg4jmvw4 141 14 blood blood NN cord-009561-pg4jmvw4 141 15 - - HYPH cord-009561-pg4jmvw4 141 16 brain brain NN cord-009561-pg4jmvw4 141 17 barrier barrier NN cord-009561-pg4jmvw4 141 18 Vacuolar Vacuolar NNP cord-009561-pg4jmvw4 141 19 myelopathy myelopathy NN cord-009561-pg4jmvw4 141 20 in in IN cord-009561-pg4jmvw4 141 21 human human JJ cord-009561-pg4jmvw4 141 22 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 141 23 virus virus NN cord-009561-pg4jmvw4 141 24 ( ( -LRB- cord-009561-pg4jmvw4 141 25 HIV HIV NNP cord-009561-pg4jmvw4 141 26 ) ) -RRB- cord-009561-pg4jmvw4 141 27 infection infection NN cord-009561-pg4jmvw4 141 28 : : : cord-009561-pg4jmvw4 141 29 central central JJ cord-009561-pg4jmvw4 141 30 remyelination remyelination NN cord-009561-pg4jmvw4 141 31 Cytokines Cytokines NNPS cord-009561-pg4jmvw4 141 32 and and CC cord-009561-pg4jmvw4 141 33 arachidonic arachidonic JJ cord-009561-pg4jmvw4 141 34 metabolites metabolite NNS cord-009561-pg4jmvw4 141 35 produced produce VBN cord-009561-pg4jmvw4 141 36 during during IN cord-009561-pg4jmvw4 141 37 human human JJ cord-009561-pg4jmvw4 141 38 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 141 39 virus virus NN cord-009561-pg4jmvw4 141 40 ( ( -LRB- cord-009561-pg4jmvw4 141 41 H1V)-infected h1v)-infected CD cord-009561-pg4jmvw4 141 42 macrophage macrophage NN cord-009561-pg4jmvw4 141 43 - - HYPH cord-009561-pg4jmvw4 141 44 astroglia astroglia JJ cord-009561-pg4jmvw4 141 45 interactions interaction NNS cord-009561-pg4jmvw4 141 46 : : : cord-009561-pg4jmvw4 141 47 implications implication NNS cord-009561-pg4jmvw4 141 48 for for IN cord-009561-pg4jmvw4 141 49 the the DT cord-009561-pg4jmvw4 141 50 neuropathogenesis neuropathogenesis NN cord-009561-pg4jmvw4 141 51 of of IN cord-009561-pg4jmvw4 141 52 HIV HIV NNP cord-009561-pg4jmvw4 141 53 disease disease NN cord-009561-pg4jmvw4 141 54 HIV HIV NNP cord-009561-pg4jmvw4 141 55 - - HYPH cord-009561-pg4jmvw4 141 56 related relate VBN cord-009561-pg4jmvw4 141 57 neurotoxicity neurotoxicity NN cord-009561-pg4jmvw4 141 58 Ghotbi Ghotbi NNP cord-009561-pg4jmvw4 141 59 2 2 CD cord-009561-pg4jmvw4 141 60 , , , cord-009561-pg4jmvw4 141 61 et et NNP cord-009561-pg4jmvw4 141 62 al al NNP cord-009561-pg4jmvw4 141 63 . . . cord-009561-pg4jmvw4 142 1 Persistent persistent JJ cord-009561-pg4jmvw4 142 2 expression expression NN cord-009561-pg4jmvw4 142 3 of of IN cord-009561-pg4jmvw4 142 4 Ia Ia NNP cord-009561-pg4jmvw4 142 5 antigen antigen NNP cord-009561-pg4jmvw4 142 6 and and CC cord-009561-pg4jmvw4 142 7 viral viral JJ cord-009561-pg4jmvw4 142 8 genome genome NN cord-009561-pg4jmvw4 142 9 in in IN cord-009561-pg4jmvw4 142 10 visna visna NNP cord-009561-pg4jmvw4 142 11 - - HYPH cord-009561-pg4jmvw4 142 12 maedi maedi JJ cord-009561-pg4jmvw4 142 13 virus virus NN cord-009561-pg4jmvw4 142 14 - - HYPH cord-009561-pg4jmvw4 142 15 induced induce VBN cord-009561-pg4jmvw4 142 16 inflammatory inflammatory JJ cord-009561-pg4jmvw4 142 17 cells cell NNS cord-009561-pg4jmvw4 142 18 : : : cord-009561-pg4jmvw4 142 19 possible possible JJ cord-009561-pg4jmvw4 142 20 role role NN cord-009561-pg4jmvw4 142 21 of of IN cord-009561-pg4jmvw4 142 22 lentivirus lentivirus NN cord-009561-pg4jmvw4 142 23 - - HYPH cord-009561-pg4jmvw4 142 24 induced induce VBN cord-009561-pg4jmvw4 142 25 interferon interferon NN cord-009561-pg4jmvw4 142 26 messenger messenger NN cord-009561-pg4jmvw4 142 27 RNA RNA NNP cord-009561-pg4jmvw4 142 28 expression expression NN cord-009561-pg4jmvw4 142 29 in in IN cord-009561-pg4jmvw4 142 30 acquired acquire VBN cord-009561-pg4jmvw4 142 31 immunodeficiency immunodeficiency NN cord-009561-pg4jmvw4 142 32 syndrome syndrome NN cord-009561-pg4jmvw4 142 33 dementia dementia NN cord-009561-pg4jmvw4 142 34 Cytokine cytokine JJ cord-009561-pg4jmvw4 142 35 expression expression NN cord-009561-pg4jmvw4 142 36 of of IN cord-009561-pg4jmvw4 142 37 macrophages macrophage NNS cord-009561-pg4jmvw4 142 38 in in IN cord-009561-pg4jmvw4 142 39 HIV-1-associated hiv-1-associate VBN cord-009561-pg4jmvw4 142 40 vacuolar vacuolar NNP cord-009561-pg4jmvw4 142 41 myelopathy myelopathy NN cord-009561-pg4jmvw4 142 42 Aetiology Aetiology NNP cord-009561-pg4jmvw4 142 43 and and CC cord-009561-pg4jmvw4 142 44 pathogenesis pathogenesis NN cord-009561-pg4jmvw4 142 45 of of IN cord-009561-pg4jmvw4 142 46 acute acute JJ cord-009561-pg4jmvw4 142 47 sporadic sporadic JJ cord-009561-pg4jmvw4 142 48 disseminated disseminate VBN cord-009561-pg4jmvw4 142 49 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 142 50 and and CC cord-009561-pg4jmvw4 142 51 multiple multiple JJ cord-009561-pg4jmvw4 142 52 sclerosis sclerosis NN cord-009561-pg4jmvw4 142 53 Viruses virus NNS cord-009561-pg4jmvw4 142 54 isolated isolate VBN cord-009561-pg4jmvw4 142 55 from from IN cord-009561-pg4jmvw4 142 56 patients patient NNS cord-009561-pg4jmvw4 142 57 with with IN cord-009561-pg4jmvw4 142 58 encephalomyelitis encephalomyelitis NN cord-009561-pg4jmvw4 142 59 and and CC cord-009561-pg4jmvw4 142 60 multiple multiple JJ cord-009561-pg4jmvw4 142 61 sclerosis sclerosis NN cord-009561-pg4jmvw4 142 62 . . . cord-009561-pg4jmvw4 143 1 I. I. NNP cord-009561-pg4jmvw4 143 2 Pathogenic pathogenic JJ cord-009561-pg4jmvw4 143 3 and and CC cord-009561-pg4jmvw4 143 4 antigenic antigenic JJ cord-009561-pg4jmvw4 143 5 properties property NNS cord-009561-pg4jmvw4 144 1 Virus virus NN cord-009561-pg4jmvw4 144 2 isolated isolate VBN cord-009561-pg4jmvw4 144 3 from from IN cord-009561-pg4jmvw4 144 4 the the DT cord-009561-pg4jmvw4 144 5 brain brain NN cord-009561-pg4jmvw4 144 6 of of IN cord-009561-pg4jmvw4 144 7 a a DT cord-009561-pg4jmvw4 144 8 patient patient NN cord-009561-pg4jmvw4 144 9 with with IN cord-009561-pg4jmvw4 144 10 multiple multiple JJ cord-009561-pg4jmvw4 144 11 sclerosis sclerosis NN cord-009561-pg4jmvw4 144 12 Transmission transmission NN cord-009561-pg4jmvw4 144 13 experiments experiment NNS cord-009561-pg4jmvw4 144 14 with with IN cord-009561-pg4jmvw4 144 15 multiple multiple JJ cord-009561-pg4jmvw4 144 16 sclerosis sclerosis NN cord-009561-pg4jmvw4 144 17 Decreased decrease VBD cord-009561-pg4jmvw4 144 18 percentage percentage NN cord-009561-pg4jmvw4 144 19 of of IN cord-009561-pg4jmvw4 144 20 polyrnorphonuclear polyrnorphonuclear JJ cord-009561-pg4jmvw4 144 21 neutrophils neutrophil NNS cord-009561-pg4jmvw4 144 22 in in IN cord-009561-pg4jmvw4 144 23 mouse mouse NN cord-009561-pg4jmvw4 144 24 peripheral peripheral JJ cord-009561-pg4jmvw4 144 25 blood blood NN cord-009561-pg4jmvw4 144 26 after after IN cord-009561-pg4jmvw4 144 27 inoculation inoculation NN cord-009561-pg4jmvw4 144 28 with with IN cord-009561-pg4jmvw4 144 29 material material NN cord-009561-pg4jmvw4 144 30 from from IN cord-009561-pg4jmvw4 144 31 multiple multiple JJ cord-009561-pg4jmvw4 144 32 sclerosis sclerosis NN cord-009561-pg4jmvw4 144 33 patients patient NNS cord-009561-pg4jmvw4 144 34 Fusion Fusion NNP cord-009561-pg4jmvw4 144 35 of of IN cord-009561-pg4jmvw4 144 36 culcured culcure VBN cord-009561-pg4jmvw4 144 37 multiple multiple JJ cord-009561-pg4jmvw4 144 38 sclerosis sclerosis NN cord-009561-pg4jmvw4 144 39 brain brain NN cord-009561-pg4jmvw4 144 40 cells cell NNS cord-009561-pg4jmvw4 144 41 with with IN cord-009561-pg4jmvw4 144 42 indicator indicator NN cord-009561-pg4jmvw4 144 43 cellspresence cellspresence NNP cord-009561-pg4jmvw4 144 44 of of IN cord-009561-pg4jmvw4 144 45 nucleocapsids nucleocapsid NNS cord-009561-pg4jmvw4 144 46 and and CC cord-009561-pg4jmvw4 144 47 virions virion NNS cord-009561-pg4jmvw4 144 48 and and CC cord-009561-pg4jmvw4 144 49 isolation isolation NN cord-009561-pg4jmvw4 144 50 of of IN cord-009561-pg4jmvw4 144 51 parainfluenza parainfluenza JJ cord-009561-pg4jmvw4 144 52 - - HYPH cord-009561-pg4jmvw4 144 53 type type NN cord-009561-pg4jmvw4 144 54 virus virus NN cord-009561-pg4jmvw4 144 55 Viruses virus NNS cord-009561-pg4jmvw4 144 56 in in IN cord-009561-pg4jmvw4 144 57 multiple multiple JJ cord-009561-pg4jmvw4 144 58 sclerosis sclerosis NN cord-009561-pg4jmvw4 144 59 ? ? . cord-009561-pg4jmvw4 145 1 Isolation isolation NN cord-009561-pg4jmvw4 145 2 of of IN cord-009561-pg4jmvw4 145 3 an an DT cord-009561-pg4jmvw4 145 4 infectious infectious JJ cord-009561-pg4jmvw4 145 5 agent agent NN cord-009561-pg4jmvw4 145 6 from from IN cord-009561-pg4jmvw4 145 7 bone bone NN cord-009561-pg4jmvw4 145 8 - - HYPH cord-009561-pg4jmvw4 145 9 marrows marrow NNS cord-009561-pg4jmvw4 145 10 of of IN cord-009561-pg4jmvw4 145 11 patients patient NNS cord-009561-pg4jmvw4 145 12 with with IN cord-009561-pg4jmvw4 145 13 multiple multiple JJ cord-009561-pg4jmvw4 145 14 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 15 Cytomegalovirus Cytomegalovirus NNP cord-009561-pg4jmvw4 145 16 isolation isolation NN cord-009561-pg4jmvw4 145 17 from from IN cord-009561-pg4jmvw4 145 18 a a DT cord-009561-pg4jmvw4 145 19 chimpanzee chimpanzee NN cord-009561-pg4jmvw4 145 20 with with IN cord-009561-pg4jmvw4 145 21 acute acute JJ cord-009561-pg4jmvw4 145 22 demyelinating demyelinate VBG cord-009561-pg4jmvw4 145 23 disease disease NN cord-009561-pg4jmvw4 145 24 after after IN cord-009561-pg4jmvw4 145 25 inoculation inoculation NN cord-009561-pg4jmvw4 145 26 of of IN cord-009561-pg4jmvw4 145 27 multiple multiple JJ cord-009561-pg4jmvw4 145 28 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 29 brain brain NN cord-009561-pg4jmvw4 145 30 cells cell NNS cord-009561-pg4jmvw4 145 31 Two two CD cord-009561-pg4jmvw4 145 32 coronaviruses coronaviruse NNS cord-009561-pg4jmvw4 145 33 isolated isolate VBN cord-009561-pg4jmvw4 145 34 from from IN cord-009561-pg4jmvw4 145 35 central central JJ cord-009561-pg4jmvw4 145 36 nervous nervous JJ cord-009561-pg4jmvw4 145 37 system system NN cord-009561-pg4jmvw4 145 38 tissue tissue NN cord-009561-pg4jmvw4 145 39 of of IN cord-009561-pg4jmvw4 145 40 two two CD cord-009561-pg4jmvw4 145 41 multiple multiple JJ cord-009561-pg4jmvw4 145 42 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 43 patients patient NNS cord-009561-pg4jmvw4 145 44 Isolation Isolation NNP cord-009561-pg4jmvw4 145 45 of of IN cord-009561-pg4jmvw4 145 46 virus virus NN cord-009561-pg4jmvw4 145 47 from from IN cord-009561-pg4jmvw4 145 48 the the DT cord-009561-pg4jmvw4 145 49 spinal spinal JJ cord-009561-pg4jmvw4 145 50 fluid fluid NN cord-009561-pg4jmvw4 145 51 of of IN cord-009561-pg4jmvw4 145 52 three three CD cord-009561-pg4jmvw4 145 53 patients patient NNS cord-009561-pg4jmvw4 145 54 with with IN cord-009561-pg4jmvw4 145 55 multiple multiple JJ cord-009561-pg4jmvw4 145 56 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 57 and and CC cord-009561-pg4jmvw4 145 58 one one CD cord-009561-pg4jmvw4 145 59 with with IN cord-009561-pg4jmvw4 145 60 amyotrophic amyotrophic JJ cord-009561-pg4jmvw4 145 61 lateral lateral JJ cord-009561-pg4jmvw4 145 62 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 63 Isolation Isolation NNP cord-009561-pg4jmvw4 145 64 of of IN cord-009561-pg4jmvw4 145 65 the the DT cord-009561-pg4jmvw4 145 66 ack ack NN cord-009561-pg4jmvw4 145 67 - - HYPH cord-009561-pg4jmvw4 145 68 borne bear VBN cord-009561-pg4jmvw4 145 69 encephalitis encephalitis JJ cord-009561-pg4jmvw4 145 70 virus virus NN cord-009561-pg4jmvw4 145 71 from from IN cord-009561-pg4jmvw4 145 72 a a DT cord-009561-pg4jmvw4 145 73 patient patient NN cord-009561-pg4jmvw4 145 74 with with IN cord-009561-pg4jmvw4 145 75 multiple multiple JJ cord-009561-pg4jmvw4 145 76 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 77 Multiple multiple JJ cord-009561-pg4jmvw4 145 78 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 79 and and CC cord-009561-pg4jmvw4 145 80 human human JJ cord-009561-pg4jmvw4 145 81 T T NNP cord-009561-pg4jmvw4 145 82 - - HYPH cord-009561-pg4jmvw4 145 83 cell cell NN cord-009561-pg4jmvw4 145 84 lymphotropic lymphotropic NNS cord-009561-pg4jmvw4 145 85 retroviruses retrovirus NNS cord-009561-pg4jmvw4 145 86 Leptomeningeal Leptomeningeal NNP cord-009561-pg4jmvw4 145 87 cell cell NN cord-009561-pg4jmvw4 145 88 line line NN cord-009561-pg4jmvw4 145 89 from from IN cord-009561-pg4jmvw4 145 90 multiple multiple JJ cord-009561-pg4jmvw4 145 91 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 92 with with IN cord-009561-pg4jmvw4 145 93 reverse reverse JJ cord-009561-pg4jmvw4 145 94 transcriptase transcriptase NN cord-009561-pg4jmvw4 145 95 activity activity NN cord-009561-pg4jmvw4 145 96 and and CC cord-009561-pg4jmvw4 145 97 viral viral JJ cord-009561-pg4jmvw4 145 98 particles particle NNS cord-009561-pg4jmvw4 145 99 Isolation isolation NN cord-009561-pg4jmvw4 145 100 of of IN cord-009561-pg4jmvw4 145 101 herpes herpes NNP cord-009561-pg4jmvw4 145 102 simplex simplex NNP cord-009561-pg4jmvw4 145 103 virus virus NN cord-009561-pg4jmvw4 145 104 type type NN cord-009561-pg4jmvw4 145 105 1 1 CD cord-009561-pg4jmvw4 145 106 during during IN cord-009561-pg4jmvw4 145 107 first first JJ cord-009561-pg4jmvw4 145 108 attack attack NN cord-009561-pg4jmvw4 145 109 of of IN cord-009561-pg4jmvw4 145 110 multiple multiple JJ cord-009561-pg4jmvw4 145 111 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 112 Viral viral JJ cord-009561-pg4jmvw4 145 113 aspects aspect NNS cord-009561-pg4jmvw4 145 114 of of IN cord-009561-pg4jmvw4 145 115 multiple multiple JJ cord-009561-pg4jmvw4 145 116 sclerosis sclerosis NN cord-009561-pg4jmvw4 145 117 Koch Koch NNP cord-009561-pg4jmvw4 145 118 's 's POS cord-009561-pg4jmvw4 145 119 postulates postulate NNS cord-009561-pg4jmvw4 145 120 and and CC cord-009561-pg4jmvw4 145 121 slow slow JJ cord-009561-pg4jmvw4 145 122 infections infection NNS cord-009561-pg4jmvw4 145 123 of of IN cord-009561-pg4jmvw4 145 124 the the DT cord-009561-pg4jmvw4 145 125 nervous nervous JJ cord-009561-pg4jmvw4 145 126 system system NN cord-009561-pg4jmvw4 145 127 Alexander Alexander NNP cord-009561-pg4jmvw4 145 128 von von NNP cord-009561-pg4jmvw4 145 129 Humboldt Humboldt NNP cord-009561-pg4jmvw4 145 130 foundation foundation NN cord-009561-pg4jmvw4 145 131 , , , cord-009561-pg4jmvw4 145 132 bi bi JJ cord-009561-pg4jmvw4 145 133 - - JJ cord-009561-pg4jmvw4 145 134 national national JJ cord-009561-pg4jmvw4 145 135 colloquium colloquium NN cord-009561-pg4jmvw4 145 136 for for IN cord-009561-pg4jmvw4 145 137 Humboldt Humboldt NNP cord-009561-pg4jmvw4 145 138 awardees awardee NNS cord-009561-pg4jmvw4 145 139 in in IN cord-009561-pg4jmvw4 145 140 cooperation cooperation NN cord-009561-pg4jmvw4 145 141 with with IN cord-009561-pg4jmvw4 145 142 the the DT cord-009561-pg4jmvw4 145 143 Institute Institute NNP cord-009561-pg4jmvw4 145 144 for for IN cord-009561-pg4jmvw4 145 145 Advanced Advanced NNP cord-009561-pg4jmvw4 145 146 Study Study NNP