id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-332856-96z48gpg	Ruocco, Eleonora	Kaposi’s sarcoma: Etiology and pathogenesis, inducing factors, causal associations, and treatments: Facts and controversies	2013-06-24		.txt	text/plain	6866	356	42	Based on these assessments, it is possible to hypothesize that the role of cofactors in KS pathogenesis can move toward an effect either favoring or inhibiting the onset of the disease, depending on the presence of other agents modulating the pathogenesis itself, such as genetic predisposition, environmental factors, drug intake, or lymph flow disorders. 37 HHV-8 virus interferes with p53 pathway at several levels: (1) the latency-associated nuclear antigen, encoded by ORF 73 of the HHV-8 genome, suppresses p53 transcription and transactivation activity, and interacts directly with the p53 protein inhibiting the ability of p53 to induce cell death 35,38 ; (2) the viral interferon (IFN) regulatory factor 4 (vIRF4), encoded by ORFK10/K10.1 of HHV-8, specifically interacts with and stabilizes murine double minute 2 (MDM2) human homologue, a well-known negative regulator of p53 via proteasome-mediated degradation, leading to the consequent reduction of p53 levels and thereby concurring to the suppression of p53-mediated apoptosis.	./cache/cord-332856-96z48gpg.txt	./txt/cord-332856-96z48gpg.txt