id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-297257-lzybfwc2	Savarino, Andrea	Chloroquine and beyond: exploring anti-rheumatic drugs to reduce immune hyperactivation in HIV/AIDS	2015-06-18		.txt	text/plain	4904	239	40	The quest for clinical candidates to counteract immune activation has become a "hot topic" in AIDS research, because HIV infection is characterized by malignant immune hyperactivation which correlates with disease progression and poor response to antiretroviral therapy (ART) [1] [2] [3] [4] [5] . We here provide a state of the art of the studies investigating the use of chloroquine/hydroxychloroquine as a therapeutic tool for HIV/AIDS and suggest the possible biological grounds for the clinical results obtained. This view is supported by another recent study which shows that chloroquine sensitizes to apoptosis the latently infected cells upon viral reactivation, likely by removing the anti-apoptotic effect of the virus structural gag gene products [50] . Published clinical studies evaluating the effects of chloroquine/hydroxychloroquine administration, alone or in combination with other drugs, in HIV infected subjects.	./cache/cord-297257-lzybfwc2.txt	./txt/cord-297257-lzybfwc2.txt