id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-102874-6z5f2gz3	Barreiro, Luis B.	The Heritage of Pathogen Pressures and Ancient Demography in the Human Innate-Immunity CD209/CD209L Region	2005-11-30		.txt	text/plain	9851	439	47	Our results, which are based on diversity levels, neutrality tests, population genetic distances, and neck-region length variation, provide genetic evidence that CD209 has been under a strong selective constraint that prevents accumulation of any amino acid changes, whereas CD209L variability has most likely been shaped by the action of balancing selection in non-African populations. Sequence variation of the CD209/CD209L region was determined in 41 sub-Saharan Africans, 43 Europeans, and 43 East Asians, in a total of 254 chromosomes from the Human Genome Diversity Panel (HGDP)-CEPH panel ). To estimate Ϫ4 8 # 10 the substitution rate of each region and evince possible mutational differences that could explain the strong contrast observed in nucleotide-diversity patterns, we determined the human-chimpanzee divergence for both genes. Overall, differences in genomic forces seem to be insufficient to explain the contrasting patterns observed at both the sequence and neck-region length variation levels; therefore, the action of differential selective pressures acting on these genes becomes the most plausible scenario.	./cache/cord-102874-6z5f2gz3.txt	./txt/cord-102874-6z5f2gz3.txt