id	sid	tid	token	lemma	pos
cord-023168-cd7adns8	1	1	key	key	NN
cord-023168-cd7adns8	1	2	:	:	:
cord-023168-cd7adns8	1	3	cord-023168-cd7adns8	cord-023168-cd7adns8	NNP
cord-023168-cd7adns8	2	1	authors	author	NNS
cord-023168-cd7adns8	2	2	:	:	:
cord-023168-cd7adns8	2	3	Thachil	Thachil	NNP
cord-023168-cd7adns8	2	4	,	,	,
cord-023168-cd7adns8	2	5	Jecko	Jecko	NNP
cord-023168-cd7adns8	2	6	;	;	:
cord-023168-cd7adns8	2	7	Owusu	Owusu	NNP
cord-023168-cd7adns8	2	8	-	-	HYPH
cord-023168-cd7adns8	2	9	Ofori	Ofori	NNP
cord-023168-cd7adns8	2	10	,	,	,
cord-023168-cd7adns8	2	11	Shirley	Shirley	NNP
cord-023168-cd7adns8	2	12	;	;	:
cord-023168-cd7adns8	2	13	Bates	Bates	NNP
cord-023168-cd7adns8	2	14	,	,	,
cord-023168-cd7adns8	2	15	Imelda	Imelda	NNP
cord-023168-cd7adns8	2	16	title	title	NN
cord-023168-cd7adns8	2	17	:	:	:
cord-023168-cd7adns8	2	18	Haematological	Haematological	NNP
cord-023168-cd7adns8	2	19	Diseases	Diseases	NNPS
cord-023168-cd7adns8	2	20	in	in	IN
cord-023168-cd7adns8	2	21	the	the	DT
cord-023168-cd7adns8	2	22	Tropics	Tropics	NNPS
cord-023168-cd7adns8	2	23	date	date	NN
cord-023168-cd7adns8	2	24	:	:	:
cord-023168-cd7adns8	2	25	2013	2013	CD
cord-023168-cd7adns8	2	26	-	-	SYM
cord-023168-cd7adns8	2	27	10	10	CD
cord-023168-cd7adns8	2	28	-	-	SYM
cord-023168-cd7adns8	2	29	21	21	CD
cord-023168-cd7adns8	2	30	journal	journal	NN
cord-023168-cd7adns8	2	31	:	:	:
cord-023168-cd7adns8	3	1	Manson	Manson	NNP
cord-023168-cd7adns8	3	2	's	's	POS
cord-023168-cd7adns8	3	3	Tropical	Tropical	NNP
cord-023168-cd7adns8	3	4	Infectious	Infectious	NNP
cord-023168-cd7adns8	3	5	Diseases	Diseases	NNPS
cord-023168-cd7adns8	3	6	DOI	doi	NN
cord-023168-cd7adns8	3	7	:	:	:
cord-023168-cd7adns8	4	1	10.1016	10.1016	CD
cord-023168-cd7adns8	4	2	/	/	SYM
cord-023168-cd7adns8	4	3	b978	b978	NN
cord-023168-cd7adns8	4	4	-	-	HYPH
cord-023168-cd7adns8	4	5	0	0	CD
cord-023168-cd7adns8	4	6	-	-	HYPH
cord-023168-cd7adns8	4	7	7020	7020	CD
cord-023168-cd7adns8	4	8	-	-	HYPH
cord-023168-cd7adns8	4	9	5101	5101	CD
cord-023168-cd7adns8	5	1	-2.00066	-2.00066	:
cord-023168-cd7adns8	5	2	-	-	HYPH
cord-023168-cd7adns8	5	3	2	2	CD
cord-023168-cd7adns8	5	4	sha	sha	NN
cord-023168-cd7adns8	5	5	:	:	:
cord-023168-cd7adns8	5	6	5cd27157498bed68b662069c144fd832d65f583e	5cd27157498bed68b662069c144fd832d65f583e	CD
cord-023168-cd7adns8	5	7	doc_id	doc_id	CD
cord-023168-cd7adns8	5	8	:	:	:
cord-023168-cd7adns8	6	1	23168	23168	CD
cord-023168-cd7adns8	6	2	cord_uid	cord_uid	NNS
cord-023168-cd7adns8	6	3	:	:	:
cord-023168-cd7adns8	7	1	cd7adns8	cd7adns8	NNP
cord-023168-cd7adns8	7	2	nan	nan	NNP
cord-023168-cd7adns8	7	3	Haematological	Haematological	NNP
cord-023168-cd7adns8	7	4	disorders	disorder	NNS
cord-023168-cd7adns8	7	5	are	be	VBP
cord-023168-cd7adns8	7	6	common	common	JJ
cord-023168-cd7adns8	7	7	in	in	IN
cord-023168-cd7adns8	7	8	low	low	JJ
cord-023168-cd7adns8	7	9	-	-	HYPH
cord-023168-cd7adns8	7	10	income	income	NN
cord-023168-cd7adns8	7	11	countries	country	NNS
cord-023168-cd7adns8	7	12	.	.	.
cord-023168-cd7adns8	8	1	They	-PRON-	PRP
cord-023168-cd7adns8	8	2	make	make	VBP
cord-023168-cd7adns8	8	3	a	a	DT
cord-023168-cd7adns8	8	4	substantial	substantial	JJ
cord-023168-cd7adns8	8	5	contribution	contribution	NN
cord-023168-cd7adns8	8	6	to	to	IN
cord-023168-cd7adns8	8	7	morbidity	morbidity	NN
cord-023168-cd7adns8	8	8	and	and	CC
cord-023168-cd7adns8	8	9	mortality	mortality	NN
cord-023168-cd7adns8	8	10	of	of	IN
cord-023168-cd7adns8	8	11	individuals	individual	NNS
cord-023168-cd7adns8	8	12	in	in	IN
cord-023168-cd7adns8	8	13	these	these	DT
cord-023168-cd7adns8	8	14	regions	region	NNS
cord-023168-cd7adns8	8	15	and	and	CC
cord-023168-cd7adns8	8	16	have	have	VBP
cord-023168-cd7adns8	8	17	a	a	DT
cord-023168-cd7adns8	8	18	negative	negative	JJ
cord-023168-cd7adns8	8	19	impact	impact	NN
cord-023168-cd7adns8	8	20	on	on	IN
cord-023168-cd7adns8	8	21	the	the	DT
cord-023168-cd7adns8	8	22	growth	growth	NN
cord-023168-cd7adns8	8	23	and	and	CC
cord-023168-cd7adns8	8	24	development	development	NN
cord-023168-cd7adns8	8	25	of	of	IN
cord-023168-cd7adns8	8	26	under	under	RB
cord-023168-cd7adns8	8	27	-	-	HYPH
cord-023168-cd7adns8	8	28	resourced	resource	VBN
cord-023168-cd7adns8	8	29	nations	nation	NNS
cord-023168-cd7adns8	8	30	.	.	.
cord-023168-cd7adns8	9	1	Genetic	genetic	JJ
cord-023168-cd7adns8	9	2	red	red	JJ
cord-023168-cd7adns8	9	3	cells	cell	NNS
cord-023168-cd7adns8	9	4	abnormalities	abnormality	NNS
cord-023168-cd7adns8	9	5	are	be	VBP
cord-023168-cd7adns8	9	6	common	common	JJ
cord-023168-cd7adns8	9	7	in	in	IN
cord-023168-cd7adns8	9	8	lowincome	lowincome	JJ
cord-023168-cd7adns8	9	9	countries	country	NNS
cord-023168-cd7adns8	9	10	because	because	IN
cord-023168-cd7adns8	9	11	they	-PRON-	PRP
cord-023168-cd7adns8	9	12	provide	provide	VBP
cord-023168-cd7adns8	9	13	protection	protection	NN
cord-023168-cd7adns8	9	14	against	against	IN
cord-023168-cd7adns8	9	15	malaria	malaria	NN
cord-023168-cd7adns8	9	16	and	and	CC
cord-023168-cd7adns8	9	17	they	-PRON-	PRP
cord-023168-cd7adns8	9	18	often	often	RB
cord-023168-cd7adns8	9	19	co	co	VBP
cord-023168-cd7adns8	9	20	-	-	VBP
cord-023168-cd7adns8	9	21	exist	exist	VB
cord-023168-cd7adns8	9	22	with	with	IN
cord-023168-cd7adns8	9	23	other	other	JJ
cord-023168-cd7adns8	9	24	causes	cause	NNS
cord-023168-cd7adns8	9	25	of	of	IN
cord-023168-cd7adns8	9	26	anaemia	anaemia	NN
cord-023168-cd7adns8	9	27	such	such	JJ
cord-023168-cd7adns8	9	28	as	as	IN
cord-023168-cd7adns8	9	29	malnutrition	malnutrition	NN
cord-023168-cd7adns8	9	30	and	and	CC
cord-023168-cd7adns8	9	31	chronic	chronic	JJ
cord-023168-cd7adns8	9	32	illnesses	illness	NNS
cord-023168-cd7adns8	9	33	.	.	.
cord-023168-cd7adns8	10	1	There	there	EX
cord-023168-cd7adns8	10	2	is	be	VBZ
cord-023168-cd7adns8	10	3	a	a	DT
cord-023168-cd7adns8	10	4	close	close	JJ
cord-023168-cd7adns8	10	5	association	association	NN
cord-023168-cd7adns8	10	6	between	between	IN
cord-023168-cd7adns8	10	7	haematological	haematological	JJ
cord-023168-cd7adns8	10	8	abnormalities	abnormality	NNS
cord-023168-cd7adns8	10	9	and	and	CC
cord-023168-cd7adns8	10	10	infections	infection	NNS
cord-023168-cd7adns8	10	11	which	which	WDT
cord-023168-cd7adns8	10	12	are	be	VBP
cord-023168-cd7adns8	10	13	a	a	DT
cord-023168-cd7adns8	10	14	major	major	JJ
cord-023168-cd7adns8	10	15	cause	cause	NN
cord-023168-cd7adns8	10	16	of	of	IN
cord-023168-cd7adns8	10	17	illness	illness	NN
cord-023168-cd7adns8	10	18	and	and	CC
cord-023168-cd7adns8	10	19	death	death	NN
cord-023168-cd7adns8	10	20	in	in	IN
cord-023168-cd7adns8	10	21	these	these	DT
cord-023168-cd7adns8	10	22	populations	population	NNS
cord-023168-cd7adns8	10	23	.	.	.
cord-023168-cd7adns8	11	1	Morphological	morphological	JJ
cord-023168-cd7adns8	11	2	abnormalities	abnormality	NNS
cord-023168-cd7adns8	11	3	of	of	IN
cord-023168-cd7adns8	11	4	blood	blood	NN
cord-023168-cd7adns8	11	5	can	can	MD
cord-023168-cd7adns8	11	6	often	often	RB
cord-023168-cd7adns8	11	7	provide	provide	VB
cord-023168-cd7adns8	11	8	clues	clue	NNS
cord-023168-cd7adns8	11	9	about	about	IN
cord-023168-cd7adns8	11	10	the	the	DT
cord-023168-cd7adns8	11	11	underlying	underlie	VBG
cord-023168-cd7adns8	11	12	diagnosis	diagnosis	NN
cord-023168-cd7adns8	11	13	and	and	CC
cord-023168-cd7adns8	11	14	blood	blood	NN
cord-023168-cd7adns8	11	15	film	film	NN
cord-023168-cd7adns8	11	16	examination	examination	NN
cord-023168-cd7adns8	11	17	is	be	VBZ
cord-023168-cd7adns8	11	18	particularly	particularly	RB
cord-023168-cd7adns8	11	19	important	important	JJ
cord-023168-cd7adns8	11	20	where	where	WRB
cord-023168-cd7adns8	11	21	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	11	22	facilities	facility	NNS
cord-023168-cd7adns8	11	23	are	be	VBP
cord-023168-cd7adns8	11	24	limited	limited	JJ
cord-023168-cd7adns8	11	25	.	.	.
cord-023168-cd7adns8	12	1	Abnormal	abnormal	JJ
cord-023168-cd7adns8	12	2	blood	blood	NN
cord-023168-cd7adns8	12	3	counts	count	NNS
cord-023168-cd7adns8	12	4	can	can	MD
cord-023168-cd7adns8	12	5	manifest	manifest	VB
cord-023168-cd7adns8	12	6	as	as	IN
cord-023168-cd7adns8	12	7	various	various	JJ
cord-023168-cd7adns8	12	8	combinations	combination	NNS
cord-023168-cd7adns8	12	9	of	of	IN
cord-023168-cd7adns8	12	10	alterations	alteration	NNS
cord-023168-cd7adns8	12	11	of	of	IN
cord-023168-cd7adns8	12	12	numbers	number	NNS
cord-023168-cd7adns8	12	13	of	of	IN
cord-023168-cd7adns8	12	14	red	red	JJ
cord-023168-cd7adns8	12	15	cells	cell	NNS
cord-023168-cd7adns8	12	16	,	,	,
cord-023168-cd7adns8	12	17	white	white	JJ
cord-023168-cd7adns8	12	18	cells	cell	NNS
cord-023168-cd7adns8	12	19	or	or	CC
cord-023168-cd7adns8	12	20	platelets	platelet	NNS
cord-023168-cd7adns8	12	21	.	.	.
cord-023168-cd7adns8	13	1	This	this	DT
cord-023168-cd7adns8	13	2	section	section	NN
cord-023168-cd7adns8	13	3	will	will	MD
cord-023168-cd7adns8	13	4	outline	outline	VB
cord-023168-cd7adns8	13	5	some	some	DT
cord-023168-cd7adns8	13	6	of	of	IN
cord-023168-cd7adns8	13	7	the	the	DT
cord-023168-cd7adns8	13	8	most	most	RBS
cord-023168-cd7adns8	13	9	common	common	JJ
cord-023168-cd7adns8	13	10	causes	cause	NNS
cord-023168-cd7adns8	13	11	of	of	IN
cord-023168-cd7adns8	13	12	abnormal	abnormal	JJ
cord-023168-cd7adns8	13	13	blood	blood	NN
cord-023168-cd7adns8	13	14	counts	count	VBZ
cord-023168-cd7adns8	13	15	likely	likely	JJ
cord-023168-cd7adns8	13	16	to	to	TO
cord-023168-cd7adns8	13	17	be	be	VB
cord-023168-cd7adns8	13	18	encountered	encounter	VBN
cord-023168-cd7adns8	13	19	in	in	IN
cord-023168-cd7adns8	13	20	clinical	clinical	JJ
cord-023168-cd7adns8	13	21	practice	practice	NN
cord-023168-cd7adns8	13	22	in	in	IN
cord-023168-cd7adns8	13	23	low	low	JJ
cord-023168-cd7adns8	13	24	-	-	HYPH
cord-023168-cd7adns8	13	25	income	income	NN
cord-023168-cd7adns8	13	26	countries	country	NNS
cord-023168-cd7adns8	13	27	.	.	.
cord-023168-cd7adns8	14	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	14	2	is	be	VBZ
cord-023168-cd7adns8	14	3	one	one	CD
cord-023168-cd7adns8	14	4	of	of	IN
cord-023168-cd7adns8	14	5	the	the	DT
cord-023168-cd7adns8	14	6	most	most	RBS
cord-023168-cd7adns8	14	7	common	common	JJ
cord-023168-cd7adns8	14	8	causes	cause	NNS
cord-023168-cd7adns8	14	9	of	of	IN
cord-023168-cd7adns8	14	10	morbidity	morbidity	NN
cord-023168-cd7adns8	14	11	in	in	IN
cord-023168-cd7adns8	14	12	the	the	DT
cord-023168-cd7adns8	14	13	world	world	NN
cord-023168-cd7adns8	14	14	and	and	CC
cord-023168-cd7adns8	14	15	its	-PRON-	PRP$
cord-023168-cd7adns8	14	16	impact	impact	NN
cord-023168-cd7adns8	14	17	is	be	VBZ
cord-023168-cd7adns8	14	18	reflected	reflect	VBN
cord-023168-cd7adns8	14	19	in	in	IN
cord-023168-cd7adns8	14	20	several	several	JJ
cord-023168-cd7adns8	14	21	of	of	IN
cord-023168-cd7adns8	14	22	the	the	DT
cord-023168-cd7adns8	14	23	health	health	NN
cord-023168-cd7adns8	14	24	-	-	HYPH
cord-023168-cd7adns8	14	25	related	relate	VBN
cord-023168-cd7adns8	14	26	Millennium	Millennium	NNP
cord-023168-cd7adns8	14	27	Development	Development	NNP
cord-023168-cd7adns8	14	28	Goals	Goals	NNPS
cord-023168-cd7adns8	14	29	.	.	.
cord-023168-cd7adns8	15	1	Although	although	IN
cord-023168-cd7adns8	15	2	anaemia	anaemia	NN
cord-023168-cd7adns8	15	3	by	by	IN
cord-023168-cd7adns8	15	4	itself	-PRON-	PRP
cord-023168-cd7adns8	15	5	is	be	VBZ
cord-023168-cd7adns8	15	6	not	not	RB
cord-023168-cd7adns8	15	7	a	a	DT
cord-023168-cd7adns8	15	8	diagnosis	diagnosis	NN
cord-023168-cd7adns8	15	9	,	,	,
cord-023168-cd7adns8	15	10	it	-PRON-	PRP
cord-023168-cd7adns8	15	11	suggests	suggest	VBZ
cord-023168-cd7adns8	15	12	that	that	IN
cord-023168-cd7adns8	15	13	there	there	EX
cord-023168-cd7adns8	15	14	is	be	VBZ
cord-023168-cd7adns8	15	15	an	an	DT
cord-023168-cd7adns8	15	16	underlying	underlie	VBG
cord-023168-cd7adns8	15	17	disease	disease	NN
cord-023168-cd7adns8	15	18	state	state	NN
cord-023168-cd7adns8	15	19	which	which	WDT
cord-023168-cd7adns8	15	20	needs	need	VBZ
cord-023168-cd7adns8	15	21	to	to	TO
cord-023168-cd7adns8	15	22	be	be	VB
cord-023168-cd7adns8	15	23	recognized	recognize	VBN
cord-023168-cd7adns8	15	24	and	and	CC
cord-023168-cd7adns8	15	25	treated	treat	VBN
cord-023168-cd7adns8	15	26	.	.	.
cord-023168-cd7adns8	16	1	It	-PRON-	PRP
cord-023168-cd7adns8	16	2	is	be	VBZ
cord-023168-cd7adns8	16	3	also	also	RB
cord-023168-cd7adns8	16	4	a	a	DT
cord-023168-cd7adns8	16	5	useful	useful	JJ
cord-023168-cd7adns8	16	6	indicator	indicator	NN
cord-023168-cd7adns8	16	7	of	of	IN
cord-023168-cd7adns8	16	8	the	the	DT
cord-023168-cd7adns8	16	9	general	general	JJ
cord-023168-cd7adns8	16	10	health	health	NN
cord-023168-cd7adns8	16	11	of	of	IN
cord-023168-cd7adns8	16	12	the	the	DT
cord-023168-cd7adns8	16	13	population	population	NN
cord-023168-cd7adns8	16	14	.	.	.
cord-023168-cd7adns8	17	1	The	the	DT
cord-023168-cd7adns8	17	2	causes	cause	NNS
cord-023168-cd7adns8	17	3	of	of	IN
cord-023168-cd7adns8	17	4	anaemia	anaemia	NN
cord-023168-cd7adns8	17	5	may	may	MD
cord-023168-cd7adns8	17	6	be	be	VB
cord-023168-cd7adns8	17	7	identified	identify	VBN
cord-023168-cd7adns8	17	8	systematically	systematically	RB
cord-023168-cd7adns8	17	9	by	by	IN
cord-023168-cd7adns8	17	10	considering	consider	VBG
cord-023168-cd7adns8	17	11	the	the	DT
cord-023168-cd7adns8	17	12	life	life	NN
cord-023168-cd7adns8	17	13	cycle	cycle	NN
cord-023168-cd7adns8	17	14	of	of	IN
cord-023168-cd7adns8	17	15	the	the	DT
cord-023168-cd7adns8	17	16	red	red	JJ
cord-023168-cd7adns8	17	17	cells	cell	NNS
cord-023168-cd7adns8	17	18	(	(	-LRB-
cord-023168-cd7adns8	17	19	Figure	figure	NN
cord-023168-cd7adns8	17	20	65	65	CD
cord-023168-cd7adns8	17	21	.1	.1	CD
cord-023168-cd7adns8	17	22	)	)	-RRB-
cord-023168-cd7adns8	17	23	.	.	.
cord-023168-cd7adns8	18	1	Nutrients	nutrient	NNS
cord-023168-cd7adns8	18	2	necessary	necessary	JJ
cord-023168-cd7adns8	18	3	for	for	IN
cord-023168-cd7adns8	18	4	red	red	JJ
cord-023168-cd7adns8	18	5	cell	cell	NN
cord-023168-cd7adns8	18	6	production	production	NN
cord-023168-cd7adns8	18	7	are	be	VBP
cord-023168-cd7adns8	18	8	absorbed	absorb	VBN
cord-023168-cd7adns8	18	9	from	from	IN
cord-023168-cd7adns8	18	10	the	the	DT
cord-023168-cd7adns8	18	11	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	18	12	tract	tract	NN
cord-023168-cd7adns8	18	13	and	and	CC
cord-023168-cd7adns8	18	14	carried	carry	VBD
cord-023168-cd7adns8	18	15	through	through	IN
cord-023168-cd7adns8	18	16	the	the	DT
cord-023168-cd7adns8	18	17	portal	portal	JJ
cord-023168-cd7adns8	18	18	vein	vein	NN
cord-023168-cd7adns8	18	19	to	to	IN
cord-023168-cd7adns8	18	20	the	the	DT
cord-023168-cd7adns8	18	21	liver	liver	NN
cord-023168-cd7adns8	18	22	and	and	CC
cord-023168-cd7adns8	18	23	ultimately	ultimately	RB
cord-023168-cd7adns8	18	24	reach	reach	VB
cord-023168-cd7adns8	18	25	the	the	DT
cord-023168-cd7adns8	18	26	bone	bone	NN
cord-023168-cd7adns8	18	27	marrow	marrow	NN
cord-023168-cd7adns8	18	28	where	where	WRB
cord-023168-cd7adns8	18	29	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	18	30	occurs	occur	VBZ
cord-023168-cd7adns8	18	31	.	.	.
cord-023168-cd7adns8	19	1	This	this	DT
cord-023168-cd7adns8	19	2	process	process	NN
cord-023168-cd7adns8	19	3	is	be	VBZ
cord-023168-cd7adns8	19	4	regulated	regulate	VBN
cord-023168-cd7adns8	19	5	by	by	IN
cord-023168-cd7adns8	19	6	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	19	7	,	,	,
cord-023168-cd7adns8	19	8	a	a	DT
cord-023168-cd7adns8	19	9	hormone	hormone	NN
cord-023168-cd7adns8	19	10	released	release	VBN
cord-023168-cd7adns8	19	11	from	from	IN
cord-023168-cd7adns8	19	12	the	the	DT
cord-023168-cd7adns8	19	13	kidneys	kidney	NNS
cord-023168-cd7adns8	19	14	mainly	mainly	RB
cord-023168-cd7adns8	19	15	in	in	IN
cord-023168-cd7adns8	19	16	response	response	NN
cord-023168-cd7adns8	19	17	to	to	IN
cord-023168-cd7adns8	19	18	hypoxia	hypoxia	NN
cord-023168-cd7adns8	19	19	.	.	.
cord-023168-cd7adns8	20	1	Mature	Mature	NNP
cord-023168-cd7adns8	20	2	•	•	NNP
cord-023168-cd7adns8	20	3	Africa	Africa	NNP
cord-023168-cd7adns8	20	4	and	and	CC
cord-023168-cd7adns8	20	5	Asia	Asia	NNP
cord-023168-cd7adns8	20	6	have	have	VBP
cord-023168-cd7adns8	20	7	more	more	JJR
cord-023168-cd7adns8	20	8	than	than	IN
cord-023168-cd7adns8	20	9	85	85	CD
cord-023168-cd7adns8	20	10	%	%	NN
cord-023168-cd7adns8	20	11	of	of	IN
cord-023168-cd7adns8	20	12	the	the	DT
cord-023168-cd7adns8	20	13	world	world	NN
cord-023168-cd7adns8	20	14	's	's	POS
cord-023168-cd7adns8	20	15	anaemic	anaemic	JJ
cord-023168-cd7adns8	20	16	populations	population	NNS
cord-023168-cd7adns8	20	17	and	and	CC
cord-023168-cd7adns8	20	18	anaemia	anaemia	NN
cord-023168-cd7adns8	20	19	burden	burden	NN
cord-023168-cd7adns8	20	20	is	be	VBZ
cord-023168-cd7adns8	20	21	highest	high	JJS
cord-023168-cd7adns8	20	22	among	among	IN
cord-023168-cd7adns8	20	23	children	child	NNS
cord-023168-cd7adns8	20	24	and	and	CC
cord-023168-cd7adns8	20	25	women	woman	NNS
cord-023168-cd7adns8	20	26	of	of	IN
cord-023168-cd7adns8	20	27	reproductive	reproductive	JJ
cord-023168-cd7adns8	20	28	age	age	NN
cord-023168-cd7adns8	20	29	.	.	.
cord-023168-cd7adns8	21	1	•	•	NNP
cord-023168-cd7adns8	22	1	The	the	DT
cord-023168-cd7adns8	22	2	accurate	accurate	JJ
cord-023168-cd7adns8	22	3	diagnosis	diagnosis	NN
cord-023168-cd7adns8	22	4	of	of	IN
cord-023168-cd7adns8	22	5	anaemia	anaemia	NN
cord-023168-cd7adns8	22	6	has	have	VBZ
cord-023168-cd7adns8	22	7	been	be	VBN
cord-023168-cd7adns8	22	8	neglected	neglect	VBN
cord-023168-cd7adns8	22	9	;	;	:
cord-023168-cd7adns8	22	10	clinical	clinical	JJ
cord-023168-cd7adns8	22	11	assessment	assessment	NN
cord-023168-cd7adns8	22	12	of	of	IN
cord-023168-cd7adns8	22	13	anaemia	anaemia	NN
cord-023168-cd7adns8	22	14	is	be	VBZ
cord-023168-cd7adns8	22	15	unreliable	unreliable	JJ
cord-023168-cd7adns8	22	16	unless	unless	IN
cord-023168-cd7adns8	22	17	the	the	DT
cord-023168-cd7adns8	22	18	anaemia	anaemia	NN
cord-023168-cd7adns8	22	19	is	be	VBZ
cord-023168-cd7adns8	22	20	severe	severe	JJ
cord-023168-cd7adns8	22	21	.	.	.
cord-023168-cd7adns8	23	1	•	•	NNP
cord-023168-cd7adns8	24	1	In	in	IN
cord-023168-cd7adns8	24	2	low	low	JJ
cord-023168-cd7adns8	24	3	-	-	HYPH
cord-023168-cd7adns8	24	4	income	income	NN
cord-023168-cd7adns8	24	5	countries	country	NNS
cord-023168-cd7adns8	24	6	,	,	,
cord-023168-cd7adns8	24	7	anaemia	anaemia	NN
cord-023168-cd7adns8	24	8	in	in	IN
cord-023168-cd7adns8	24	9	an	an	DT
cord-023168-cd7adns8	24	10	individual	individual	NN
cord-023168-cd7adns8	24	11	is	be	VBZ
cord-023168-cd7adns8	24	12	often	often	RB
cord-023168-cd7adns8	24	13	due	due	JJ
cord-023168-cd7adns8	24	14	to	to	IN
cord-023168-cd7adns8	24	15	multiple	multiple	JJ
cord-023168-cd7adns8	24	16	interdependent	interdependent	JJ
cord-023168-cd7adns8	24	17	factors	factor	NNS
cord-023168-cd7adns8	24	18	.	.	.
cord-023168-cd7adns8	25	1	Removing	remove	VBG
cord-023168-cd7adns8	25	2	or	or	CC
cord-023168-cd7adns8	25	3	treating	treat	VBG
cord-023168-cd7adns8	25	4	a	a	DT
cord-023168-cd7adns8	25	5	single	single	JJ
cord-023168-cd7adns8	25	6	factor	factor	NN
cord-023168-cd7adns8	25	7	may	may	MD
cord-023168-cd7adns8	25	8	not	not	RB
cord-023168-cd7adns8	25	9	resolve	resolve	VB
cord-023168-cd7adns8	25	10	the	the	DT
cord-023168-cd7adns8	25	11	anaemia	anaemia	NN
cord-023168-cd7adns8	25	12	.	.	.
cord-023168-cd7adns8	26	1	•	•	NNP
cord-023168-cd7adns8	26	2	Early	early	JJ
cord-023168-cd7adns8	26	3	diagnosis	diagnosis	NN
cord-023168-cd7adns8	26	4	of	of	IN
cord-023168-cd7adns8	26	5	sickle	sickle	NN
cord-023168-cd7adns8	26	6	cell	cell	NN
cord-023168-cd7adns8	26	7	disease	disease	NN
cord-023168-cd7adns8	26	8	and	and	CC
cord-023168-cd7adns8	26	9	rapid	rapid	JJ
cord-023168-cd7adns8	26	10	access	access	NN
cord-023168-cd7adns8	26	11	to	to	IN
cord-023168-cd7adns8	26	12	a	a	DT
cord-023168-cd7adns8	26	13	specialist	specialist	JJ
cord-023168-cd7adns8	26	14	centre	centre	NN
cord-023168-cd7adns8	26	15	for	for	IN
cord-023168-cd7adns8	26	16	emergencies	emergency	NNS
cord-023168-cd7adns8	26	17	such	such	JJ
cord-023168-cd7adns8	26	18	as	as	IN
cord-023168-cd7adns8	26	19	severe	severe	JJ
cord-023168-cd7adns8	26	20	pain	pain	NN
cord-023168-cd7adns8	26	21	crises	crisis	NNS
cord-023168-cd7adns8	26	22	,	,	,
cord-023168-cd7adns8	26	23	strokes	stroke	NNS
cord-023168-cd7adns8	26	24	and	and	CC
cord-023168-cd7adns8	26	25	acute	acute	JJ
cord-023168-cd7adns8	26	26	chest	chest	NN
cord-023168-cd7adns8	26	27	syndrome	syndrome	NN
cord-023168-cd7adns8	26	28	,	,	,
cord-023168-cd7adns8	26	29	can	can	MD
cord-023168-cd7adns8	26	30	help	help	VB
cord-023168-cd7adns8	26	31	to	to	TO
cord-023168-cd7adns8	26	32	prevent	prevent	VB
cord-023168-cd7adns8	26	33	permanent	permanent	JJ
cord-023168-cd7adns8	26	34	long	long	JJ
cord-023168-cd7adns8	26	35	-	-	HYPH
cord-023168-cd7adns8	26	36	term	term	NN
cord-023168-cd7adns8	26	37	complications	complication	NNS
cord-023168-cd7adns8	26	38	.	.	.
cord-023168-cd7adns8	27	1	•	•	NNP
cord-023168-cd7adns8	28	1	Beta	beta	JJ
cord-023168-cd7adns8	28	2	-	-	HYPH
cord-023168-cd7adns8	28	3	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	28	4	major	major	NN
cord-023168-cd7adns8	28	5	is	be	VBZ
cord-023168-cd7adns8	28	6	fatal	fatal	JJ
cord-023168-cd7adns8	28	7	in	in	IN
cord-023168-cd7adns8	28	8	the	the	DT
cord-023168-cd7adns8	28	9	first	first	JJ
cord-023168-cd7adns8	28	10	few	few	JJ
cord-023168-cd7adns8	28	11	years	year	NNS
cord-023168-cd7adns8	28	12	of	of	IN
cord-023168-cd7adns8	28	13	life	life	NN
cord-023168-cd7adns8	28	14	unless	unless	IN
cord-023168-cd7adns8	28	15	regular	regular	JJ
cord-023168-cd7adns8	28	16	blood	blood	NN
cord-023168-cd7adns8	28	17	transfusions	transfusion	NNS
cord-023168-cd7adns8	28	18	are	be	VBP
cord-023168-cd7adns8	28	19	given	give	VBN
cord-023168-cd7adns8	28	20	;	;	:
cord-023168-cd7adns8	28	21	unless	unless	IN
cord-023168-cd7adns8	28	22	they	-PRON-	PRP
cord-023168-cd7adns8	28	23	are	be	VBP
cord-023168-cd7adns8	28	24	accompanied	accompany	VBN
cord-023168-cd7adns8	28	25	by	by	IN
cord-023168-cd7adns8	28	26	iron	iron	NN
cord-023168-cd7adns8	28	27	chelation	chelation	NN
cord-023168-cd7adns8	28	28	,	,	,
cord-023168-cd7adns8	28	29	these	these	DT
cord-023168-cd7adns8	28	30	transfusions	transfusion	NNS
cord-023168-cd7adns8	28	31	will	will	MD
cord-023168-cd7adns8	28	32	eventually	eventually	RB
cord-023168-cd7adns8	28	33	cause	cause	VB
cord-023168-cd7adns8	28	34	death	death	NN
cord-023168-cd7adns8	28	35	due	due	IN
cord-023168-cd7adns8	28	36	to	to	IN
cord-023168-cd7adns8	28	37	irreversible	irreversible	JJ
cord-023168-cd7adns8	28	38	organ	organ	NN
cord-023168-cd7adns8	28	39	damage	damage	NN
cord-023168-cd7adns8	28	40	from	from	IN
cord-023168-cd7adns8	28	41	iron	iron	NN
cord-023168-cd7adns8	28	42	overload	overload	NN
cord-023168-cd7adns8	28	43	.	.	.
cord-023168-cd7adns8	29	1	•	•	NNP
cord-023168-cd7adns8	30	1	Malarial	malarial	JJ
cord-023168-cd7adns8	30	2	anaemia	anaemia	NN
cord-023168-cd7adns8	30	3	is	be	VBZ
cord-023168-cd7adns8	30	4	a	a	DT
cord-023168-cd7adns8	30	5	particular	particular	JJ
cord-023168-cd7adns8	30	6	problem	problem	NN
cord-023168-cd7adns8	30	7	for	for	IN
cord-023168-cd7adns8	30	8	children	child	NNS
cord-023168-cd7adns8	30	9	and	and	CC
cord-023168-cd7adns8	30	10	pregnant	pregnant	JJ
cord-023168-cd7adns8	30	11	women	woman	NNS
cord-023168-cd7adns8	30	12	and	and	CC
cord-023168-cd7adns8	30	13	severe	severe	JJ
cord-023168-cd7adns8	30	14	anaemia	anaemia	NN
cord-023168-cd7adns8	30	15	can	can	MD
cord-023168-cd7adns8	30	16	be	be	VB
cord-023168-cd7adns8	30	17	caused	cause	VBN
cord-023168-cd7adns8	30	18	by	by	IN
cord-023168-cd7adns8	30	19	P.	P.	NNP
cord-023168-cd7adns8	30	20	falciparum	falciparum	NNP
cord-023168-cd7adns8	30	21	and	and	CC
cord-023168-cd7adns8	30	22	P.	P.	NNP
cord-023168-cd7adns8	30	23	vivax	vivax	NN
cord-023168-cd7adns8	30	24	.	.	.
cord-023168-cd7adns8	31	1	Malarial	malarial	JJ
cord-023168-cd7adns8	31	2	anaemia	anaemia	NN
cord-023168-cd7adns8	31	3	can	can	MD
cord-023168-cd7adns8	31	4	be	be	VB
cord-023168-cd7adns8	31	5	reduced	reduce	VBN
cord-023168-cd7adns8	31	6	with	with	IN
cord-023168-cd7adns8	31	7	chemoprophylaxis	chemoprophylaxis	JJ
cord-023168-cd7adns8	31	8	and	and	CC
cord-023168-cd7adns8	31	9	intermittent	intermittent	JJ
cord-023168-cd7adns8	31	10	treatment	treatment	NN
cord-023168-cd7adns8	31	11	,	,	,
cord-023168-cd7adns8	31	12	and	and	CC
cord-023168-cd7adns8	31	13	by	by	IN
cord-023168-cd7adns8	31	14	anti	anti	JJ
cord-023168-cd7adns8	31	15	-	-	JJ
cord-023168-cd7adns8	31	16	mosquito	mosquito	JJ
cord-023168-cd7adns8	31	17	measures	measure	NNS
cord-023168-cd7adns8	31	18	such	such	JJ
cord-023168-cd7adns8	31	19	as	as	IN
cord-023168-cd7adns8	31	20	insecticidetreated	insecticidetreate	VBN
cord-023168-cd7adns8	31	21	bed	bed	NN
cord-023168-cd7adns8	31	22	nets	net	NNS
cord-023168-cd7adns8	31	23	and	and	CC
cord-023168-cd7adns8	31	24	vector	vector	NN
cord-023168-cd7adns8	31	25	control	control	NN
cord-023168-cd7adns8	31	26	.	.	.
cord-023168-cd7adns8	32	1	•	•	NNP
cord-023168-cd7adns8	33	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	33	2	occurs	occur	VBZ
cord-023168-cd7adns8	33	3	in	in	IN
cord-023168-cd7adns8	33	4	70	70	CD
cord-023168-cd7adns8	33	5	%	%	NN
cord-023168-cd7adns8	33	6	of	of	IN
cord-023168-cd7adns8	33	7	HIV	HIV	NNP
cord-023168-cd7adns8	33	8	-	-	HYPH
cord-023168-cd7adns8	33	9	infected	infect	VBN
cord-023168-cd7adns8	33	10	patients	patient	NNS
cord-023168-cd7adns8	33	11	and	and	CC
cord-023168-cd7adns8	33	12	is	be	VBZ
cord-023168-cd7adns8	33	13	an	an	DT
cord-023168-cd7adns8	33	14	independent	independent	JJ
cord-023168-cd7adns8	33	15	risk	risk	NN
cord-023168-cd7adns8	33	16	factor	factor	NN
cord-023168-cd7adns8	33	17	for	for	IN
cord-023168-cd7adns8	33	18	death	death	NN
cord-023168-cd7adns8	33	19	.	.	.
cord-023168-cd7adns8	34	1	Prompt	prompt	JJ
cord-023168-cd7adns8	34	2	treatment	treatment	NN
cord-023168-cd7adns8	34	3	of	of	IN
cord-023168-cd7adns8	34	4	factors	factor	NNS
cord-023168-cd7adns8	34	5	associated	associate	VBN
cord-023168-cd7adns8	34	6	with	with	IN
cord-023168-cd7adns8	34	7	anaemia	anaemia	NN
cord-023168-cd7adns8	34	8	,	,	,
cord-023168-cd7adns8	34	9	such	such	JJ
cord-023168-cd7adns8	34	10	as	as	IN
cord-023168-cd7adns8	34	11	infections	infection	NNS
cord-023168-cd7adns8	34	12	and	and	CC
cord-023168-cd7adns8	34	13	poor	poor	JJ
cord-023168-cd7adns8	34	14	nutrition	nutrition	NN
cord-023168-cd7adns8	34	15	,	,	,
cord-023168-cd7adns8	34	16	and	and	CC
cord-023168-cd7adns8	34	17	commencement	commencement	NN
cord-023168-cd7adns8	34	18	of	of	IN
cord-023168-cd7adns8	34	19	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	34	20	treatment	treatment	NN
cord-023168-cd7adns8	34	21	will	will	MD
cord-023168-cd7adns8	34	22	reduce	reduce	VB
cord-023168-cd7adns8	34	23	deaths	death	NNS
cord-023168-cd7adns8	34	24	.	.	.
cord-023168-cd7adns8	35	1	•	•	NNP
cord-023168-cd7adns8	36	1	Blood	blood	NN
cord-023168-cd7adns8	36	2	shortages	shortage	NNS
cord-023168-cd7adns8	36	3	are	be	VBP
cord-023168-cd7adns8	36	4	common	common	JJ
cord-023168-cd7adns8	36	5	in	in	IN
cord-023168-cd7adns8	36	6	tropical	tropical	JJ
cord-023168-cd7adns8	36	7	countries	country	NNS
cord-023168-cd7adns8	36	8	.	.	.
cord-023168-cd7adns8	37	1	To	to	TO
cord-023168-cd7adns8	37	2	increase	increase	VB
cord-023168-cd7adns8	37	3	the	the	DT
cord-023168-cd7adns8	37	4	availability	availability	NN
cord-023168-cd7adns8	37	5	of	of	IN
cord-023168-cd7adns8	37	6	blood	blood	NN
cord-023168-cd7adns8	37	7	,	,	,
cord-023168-cd7adns8	37	8	transfusions	transfusion	NNS
cord-023168-cd7adns8	37	9	should	should	MD
cord-023168-cd7adns8	37	10	be	be	VB
cord-023168-cd7adns8	37	11	prescribed	prescribe	VBN
cord-023168-cd7adns8	37	12	in	in	IN
cord-023168-cd7adns8	37	13	accordance	accordance	NN
cord-023168-cd7adns8	37	14	with	with	IN
cord-023168-cd7adns8	37	15	guidelines	guideline	NNS
cord-023168-cd7adns8	37	16	and	and	CC
cord-023168-cd7adns8	37	17	efforts	effort	NNS
cord-023168-cd7adns8	37	18	made	make	VBN
cord-023168-cd7adns8	37	19	to	to	TO
cord-023168-cd7adns8	37	20	encourage	encourage	VB
cord-023168-cd7adns8	37	21	blood	blood	NN
cord-023168-cd7adns8	37	22	donors	donor	NNS
cord-023168-cd7adns8	37	23	to	to	TO
cord-023168-cd7adns8	37	24	donate	donate	VB
cord-023168-cd7adns8	37	25	regularly	regularly	RB
cord-023168-cd7adns8	37	26	as	as	IN
cord-023168-cd7adns8	37	27	repeat	repeat	NN
cord-023168-cd7adns8	37	28	donors	donor	NNS
cord-023168-cd7adns8	37	29	are	be	VBP
cord-023168-cd7adns8	37	30	the	the	DT
cord-023168-cd7adns8	37	31	safest	safe	JJS
cord-023168-cd7adns8	37	32	type	type	NN
cord-023168-cd7adns8	37	33	of	of	IN
cord-023168-cd7adns8	37	34	donor	donor	NN
cord-023168-cd7adns8	37	35	.	.	.
cord-023168-cd7adns8	38	1	reaction	reaction	NN
cord-023168-cd7adns8	38	2	'	'	''
cord-023168-cd7adns8	38	3	,	,	,
cord-023168-cd7adns8	38	4	characterized	characterize	VBN
cord-023168-cd7adns8	38	5	by	by	IN
cord-023168-cd7adns8	38	6	circulating	circulate	VBG
cord-023168-cd7adns8	38	7	myelocytes	myelocyte	NNS
cord-023168-cd7adns8	38	8	and	and	CC
cord-023168-cd7adns8	38	9	metamyelocytes	metamyelocyte	NNS
cord-023168-cd7adns8	38	10	,	,	,
cord-023168-cd7adns8	38	11	can	can	MD
cord-023168-cd7adns8	38	12	be	be	VB
cord-023168-cd7adns8	38	13	mistaken	mistake	VBN
cord-023168-cd7adns8	38	14	for	for	IN
cord-023168-cd7adns8	38	15	leukaemia	leukaemia	NN
cord-023168-cd7adns8	38	16	but	but	CC
cord-023168-cd7adns8	38	17	,	,	,
cord-023168-cd7adns8	38	18	unlike	unlike	IN
cord-023168-cd7adns8	38	19	leukaemia	leukaemia	NN
cord-023168-cd7adns8	38	20	,	,	,
cord-023168-cd7adns8	38	21	there	there	EX
cord-023168-cd7adns8	38	22	is	be	VBZ
cord-023168-cd7adns8	38	23	an	an	DT
cord-023168-cd7adns8	38	24	orderly	orderly	JJ
cord-023168-cd7adns8	38	25	maturation	maturation	NN
cord-023168-cd7adns8	38	26	and	and	CC
cord-023168-cd7adns8	38	27	proliferation	proliferation	NN
cord-023168-cd7adns8	38	28	of	of	IN
cord-023168-cd7adns8	38	29	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	38	30	.	.	.
cord-023168-cd7adns8	39	1	Leukaemoid	Leukaemoid	NNP
cord-023168-cd7adns8	39	2	reactions	reaction	NNS
cord-023168-cd7adns8	39	3	have	have	VBP
cord-023168-cd7adns8	39	4	also	also	RB
cord-023168-cd7adns8	39	5	been	be	VBN
cord-023168-cd7adns8	39	6	described	describe	VBN
cord-023168-cd7adns8	39	7	in	in	IN
cord-023168-cd7adns8	39	8	patients	patient	NNS
cord-023168-cd7adns8	39	9	with	with	IN
cord-023168-cd7adns8	39	10	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	39	11	,	,	,
cord-023168-cd7adns8	39	12	juvenile	juvenile	JJ
cord-023168-cd7adns8	39	13	rheumatoid	rheumatoid	NN
cord-023168-cd7adns8	39	14	arthritis	arthritis	NN
cord-023168-cd7adns8	39	15	and	and	CC
cord-023168-cd7adns8	39	16	dermatitis	dermatitis	NN
cord-023168-cd7adns8	39	17	herpetiformis	herpetiformis	NNP
cord-023168-cd7adns8	39	18	.	.	.
cord-023168-cd7adns8	40	1	2	2	LS
cord-023168-cd7adns8	40	2	,	,	,
cord-023168-cd7adns8	40	3	3	3	CD
cord-023168-cd7adns8	40	4	Decreased	decrease	VBD
cord-023168-cd7adns8	40	5	margination	margination	NN
cord-023168-cd7adns8	40	6	of	of	IN
cord-023168-cd7adns8	40	7	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	40	8	with	with	IN
cord-023168-cd7adns8	40	9	egress	egress	NN
cord-023168-cd7adns8	40	10	of	of	IN
cord-023168-cd7adns8	40	11	cells	cell	NNS
cord-023168-cd7adns8	40	12	into	into	IN
cord-023168-cd7adns8	40	13	the	the	DT
cord-023168-cd7adns8	40	14	circulation	circulation	NN
cord-023168-cd7adns8	40	15	can	can	MD
cord-023168-cd7adns8	40	16	occur	occur	VB
cord-023168-cd7adns8	40	17	with	with	IN
cord-023168-cd7adns8	40	18	exercise	exercise	NN
cord-023168-cd7adns8	40	19	,	,	,
cord-023168-cd7adns8	40	20	adrenaline	adrenaline	NN
cord-023168-cd7adns8	40	21	(	(	-LRB-
cord-023168-cd7adns8	40	22	epinephrine	epinephrine	NN
cord-023168-cd7adns8	40	23	)	)	-RRB-
cord-023168-cd7adns8	40	24	injection	injection	NN
cord-023168-cd7adns8	40	25	,	,	,
cord-023168-cd7adns8	40	26	emotional	emotional	JJ
cord-023168-cd7adns8	40	27	stress	stress	NN
cord-023168-cd7adns8	40	28	and	and	CC
cord-023168-cd7adns8	40	29	postoperatively	postoperatively	RB
cord-023168-cd7adns8	40	30	or	or	CC
cord-023168-cd7adns8	40	31	in	in	IN
cord-023168-cd7adns8	40	32	response	response	NN
cord-023168-cd7adns8	40	33	to	to	IN
cord-023168-cd7adns8	40	34	drugs	drug	NNS
cord-023168-cd7adns8	40	35	(	(	-LRB-
cord-023168-cd7adns8	40	36	e.g.	e.g.	IN
cord-023168-cd7adns8	40	37	steroids	steroid	NNS
cord-023168-cd7adns8	40	38	,	,	,
cord-023168-cd7adns8	40	39	β	β	NN
cord-023168-cd7adns8	40	40	-	-	HYPH
cord-023168-cd7adns8	40	41	agonists	agonist	NNS
cord-023168-cd7adns8	40	42	)	)	-RRB-
cord-023168-cd7adns8	40	43	.	.	.
cord-023168-cd7adns8	41	1	Other	other	JJ
cord-023168-cd7adns8	41	2	drugs	drug	NNS
cord-023168-cd7adns8	41	3	,	,	,
cord-023168-cd7adns8	41	4	such	such	JJ
cord-023168-cd7adns8	41	5	as	as	IN
cord-023168-cd7adns8	41	6	lithium	lithium	NN
cord-023168-cd7adns8	41	7	and	and	CC
cord-023168-cd7adns8	41	8	tetracycline	tetracycline	NN
cord-023168-cd7adns8	41	9	,	,	,
cord-023168-cd7adns8	41	10	produce	produce	VB
cord-023168-cd7adns8	41	11	neutrophilia	neutrophilia	NNS
cord-023168-cd7adns8	41	12	through	through	IN
cord-023168-cd7adns8	41	13	increased	increase	VBN
cord-023168-cd7adns8	41	14	production	production	NN
cord-023168-cd7adns8	41	15	.	.	.
cord-023168-cd7adns8	42	1	Neutrophilia	Neutrophilia	NNP
cord-023168-cd7adns8	42	2	is	be	VBZ
cord-023168-cd7adns8	42	3	also	also	RB
cord-023168-cd7adns8	42	4	a	a	DT
cord-023168-cd7adns8	42	5	feature	feature	NN
cord-023168-cd7adns8	42	6	of	of	IN
cord-023168-cd7adns8	42	7	bone	bone	NN
cord-023168-cd7adns8	42	8	marrow	marrow	NN
cord-023168-cd7adns8	42	9	proliferation	proliferation	NN
cord-023168-cd7adns8	42	10	which	which	WDT
cord-023168-cd7adns8	42	11	occurs	occur	VBZ
cord-023168-cd7adns8	42	12	in	in	IN
cord-023168-cd7adns8	42	13	myeloproliferative	myeloproliferative	JJ
cord-023168-cd7adns8	42	14	neoplasms	neoplasm	NNS
cord-023168-cd7adns8	42	15	,	,	,
cord-023168-cd7adns8	42	16	particularly	particularly	RB
cord-023168-cd7adns8	42	17	chronic	chronic	JJ
cord-023168-cd7adns8	42	18	myeloid	myeloid	NN
cord-023168-cd7adns8	42	19	leukemia	leukemia	NN
cord-023168-cd7adns8	42	20	and	and	CC
cord-023168-cd7adns8	42	21	myelofibrosis	myelofibrosis	NNP
cord-023168-cd7adns8	42	22	.	.	.
cord-023168-cd7adns8	43	1	Teardrop	teardrop	NN
cord-023168-cd7adns8	43	2	cells	cell	NNS
cord-023168-cd7adns8	43	3	and	and	CC
cord-023168-cd7adns8	43	4	nucleated	nucleated	JJ
cord-023168-cd7adns8	43	5	red	red	JJ
cord-023168-cd7adns8	43	6	blood	blood	NN
cord-023168-cd7adns8	43	7	cells	cell	NNS
cord-023168-cd7adns8	43	8	are	be	VBP
cord-023168-cd7adns8	43	9	features	feature	NNS
cord-023168-cd7adns8	43	10	of	of	IN
cord-023168-cd7adns8	43	11	myelofibrosis	myelofibrosis	NN
cord-023168-cd7adns8	43	12	on	on	IN
cord-023168-cd7adns8	43	13	the	the	DT
cord-023168-cd7adns8	43	14	blood	blood	NN
cord-023168-cd7adns8	43	15	film	film	NN
cord-023168-cd7adns8	43	16	;	;	:
cord-023168-cd7adns8	43	17	basophilia	basophilia	NNP
cord-023168-cd7adns8	43	18	and	and	CC
cord-023168-cd7adns8	43	19	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	43	20	are	be	VBP
cord-023168-cd7adns8	43	21	common	common	JJ
cord-023168-cd7adns8	43	22	with	with	IN
cord-023168-cd7adns8	43	23	chronic	chronic	JJ
cord-023168-cd7adns8	43	24	myeloid	myeloid	NN
cord-023168-cd7adns8	43	25	leukaemia	leukaemia	NN
cord-023168-cd7adns8	43	26	.	.	.
cord-023168-cd7adns8	44	1	Molecular	molecular	JJ
cord-023168-cd7adns8	44	2	testing	testing	NN
cord-023168-cd7adns8	44	3	for	for	IN
cord-023168-cd7adns8	44	4	the	the	DT
cord-023168-cd7adns8	44	5	JAK-2	JAK-2	NNP
cord-023168-cd7adns8	44	6	mutation	mutation	NN
cord-023168-cd7adns8	44	7	or	or	CC
cord-023168-cd7adns8	44	8	BCR	BCR	NNP
cord-023168-cd7adns8	44	9	-	-	HYPH
cord-023168-cd7adns8	44	10	ABL	ABL	NNP
cord-023168-cd7adns8	44	11	fusion	fusion	NN
cord-023168-cd7adns8	44	12	gene	gene	NN
cord-023168-cd7adns8	44	13	can	can	MD
cord-023168-cd7adns8	44	14	also	also	RB
cord-023168-cd7adns8	44	15	help	help	VB
cord-023168-cd7adns8	44	16	to	to	TO
cord-023168-cd7adns8	44	17	differentiate	differentiate	VB
cord-023168-cd7adns8	44	18	between	between	IN
cord-023168-cd7adns8	44	19	myeloproliferative	myeloproliferative	JJ
cord-023168-cd7adns8	44	20	neoplasms	neoplasm	NNS
cord-023168-cd7adns8	44	21	.	.	.
cord-023168-cd7adns8	45	1	Rebound	Rebound	NNP
cord-023168-cd7adns8	45	2	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	45	3	can	can	MD
cord-023168-cd7adns8	45	4	occur	occur	VB
cord-023168-cd7adns8	45	5	following	follow	VBG
cord-023168-cd7adns8	45	6	treatment	treatment	NN
cord-023168-cd7adns8	45	7	of	of	IN
cord-023168-cd7adns8	45	8	megaloblastic	megaloblastic	JJ
cord-023168-cd7adns8	45	9	anaemia	anaemia	NN
cord-023168-cd7adns8	45	10	or	or	CC
cord-023168-cd7adns8	45	11	after	after	IN
cord-023168-cd7adns8	45	12	recovery	recovery	NN
cord-023168-cd7adns8	45	13	from	from	IN
cord-023168-cd7adns8	45	14	neutropenia	neutropenia	NN
cord-023168-cd7adns8	45	15	induced	induce	VBN
cord-023168-cd7adns8	45	16	by	by	IN
cord-023168-cd7adns8	45	17	drugs	drug	NNS
cord-023168-cd7adns8	45	18	.	.	.
cord-023168-cd7adns8	46	1	Acute	acute	JJ
cord-023168-cd7adns8	46	2	haemorrhage	haemorrhage	NN
cord-023168-cd7adns8	46	3	can	can	MD
cord-023168-cd7adns8	46	4	cause	cause	VB
cord-023168-cd7adns8	46	5	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	46	6	,	,	,
cord-023168-cd7adns8	46	7	especially	especially	RB
cord-023168-cd7adns8	46	8	if	if	IN
cord-023168-cd7adns8	46	9	bleeding	bleeding	NN
cord-023168-cd7adns8	46	10	occurs	occur	VBZ
cord-023168-cd7adns8	46	11	into	into	IN
cord-023168-cd7adns8	46	12	the	the	DT
cord-023168-cd7adns8	46	13	peritoneal	peritoneal	JJ
cord-023168-cd7adns8	46	14	cavity	cavity	NN
cord-023168-cd7adns8	46	15	,	,	,
cord-023168-cd7adns8	46	16	pleural	pleural	JJ
cord-023168-cd7adns8	46	17	space	space	NN
cord-023168-cd7adns8	46	18	,	,	,
cord-023168-cd7adns8	46	19	joints	joint	NNS
cord-023168-cd7adns8	46	20	or	or	CC
cord-023168-cd7adns8	46	21	adjacent	adjacent	JJ
cord-023168-cd7adns8	46	22	to	to	IN
cord-023168-cd7adns8	46	23	the	the	DT
cord-023168-cd7adns8	46	24	dura	dura	NN
cord-023168-cd7adns8	46	25	.	.	.
cord-023168-cd7adns8	47	1	This	this	DT
cord-023168-cd7adns8	47	2	is	be	VBZ
cord-023168-cd7adns8	47	3	possibly	possibly	RB
cord-023168-cd7adns8	47	4	due	due	JJ
cord-023168-cd7adns8	47	5	to	to	IN
cord-023168-cd7adns8	47	6	the	the	DT
cord-023168-cd7adns8	47	7	release	release	NN
cord-023168-cd7adns8	47	8	of	of	IN
cord-023168-cd7adns8	47	9	adrenaline	adrenaline	NN
cord-023168-cd7adns8	47	10	and	and	CC
cord-023168-cd7adns8	47	11	chemokines	chemokine	NNS
cord-023168-cd7adns8	47	12	in	in	IN
cord-023168-cd7adns8	47	13	response	response	NN
cord-023168-cd7adns8	47	14	to	to	IN
cord-023168-cd7adns8	47	15	local	local	JJ
cord-023168-cd7adns8	47	16	inflammation	inflammation	NN
cord-023168-cd7adns8	47	17	.	.	.
cord-023168-cd7adns8	48	1	The	the	DT
cord-023168-cd7adns8	48	2	presence	presence	NN
cord-023168-cd7adns8	48	3	of	of	IN
cord-023168-cd7adns8	48	4	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	48	5	can	can	MD
cord-023168-cd7adns8	48	6	be	be	VB
cord-023168-cd7adns8	48	7	useful	useful	JJ
cord-023168-cd7adns8	48	8	in	in	IN
cord-023168-cd7adns8	48	9	raising	raise	VBG
cord-023168-cd7adns8	48	10	suspicions	suspicion	NNS
cord-023168-cd7adns8	48	11	about	about	IN
cord-023168-cd7adns8	48	12	the	the	DT
cord-023168-cd7adns8	48	13	onset	onset	NN
cord-023168-cd7adns8	48	14	of	of	IN
cord-023168-cd7adns8	48	15	complications	complication	NNS
cord-023168-cd7adns8	48	16	in	in	IN
cord-023168-cd7adns8	48	17	infections	infection	NNS
cord-023168-cd7adns8	48	18	that	that	WDT
cord-023168-cd7adns8	48	19	are	be	VBP
cord-023168-cd7adns8	48	20	not	not	RB
cord-023168-cd7adns8	48	21	primarily	primarily	RB
cord-023168-cd7adns8	48	22	associated	associate	VBN
cord-023168-cd7adns8	48	23	with	with	IN
cord-023168-cd7adns8	48	24	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	48	25	.	.	.
cord-023168-cd7adns8	49	1	Examples	example	NNS
cord-023168-cd7adns8	49	2	include	include	VBP
cord-023168-cd7adns8	49	3	meningitis	meningitis	NN
cord-023168-cd7adns8	49	4	in	in	IN
cord-023168-cd7adns8	49	5	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	49	6	,	,	,
cord-023168-cd7adns8	49	7	orchitis	orchitis	NN
cord-023168-cd7adns8	49	8	in	in	IN
cord-023168-cd7adns8	49	9	mumps	mumps	NN
cord-023168-cd7adns8	49	10	,	,	,
cord-023168-cd7adns8	49	11	bowel	bowel	NN
cord-023168-cd7adns8	49	12	perforation	perforation	NN
cord-023168-cd7adns8	49	13	in	in	IN
cord-023168-cd7adns8	49	14	typhoid	typhoid	NN
cord-023168-cd7adns8	49	15	fever	fever	NN
cord-023168-cd7adns8	49	16	and	and	CC
cord-023168-cd7adns8	49	17	superadded	superadde	VBN
cord-023168-cd7adns8	49	18	bacterial	bacterial	JJ
cord-023168-cd7adns8	49	19	infection	infection	NN
cord-023168-cd7adns8	49	20	in	in	IN
cord-023168-cd7adns8	49	21	measles	measle	NNS
cord-023168-cd7adns8	49	22	.	.	.
cord-023168-cd7adns8	50	1	The	the	DT
cord-023168-cd7adns8	50	2	absence	absence	NN
cord-023168-cd7adns8	50	3	of	of	IN
cord-023168-cd7adns8	50	4	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	50	5	can	can	MD
cord-023168-cd7adns8	50	6	be	be	VB
cord-023168-cd7adns8	50	7	helpful	helpful	JJ
cord-023168-cd7adns8	50	8	in	in	IN
cord-023168-cd7adns8	50	9	differentiating	differentiate	VBG
cord-023168-cd7adns8	50	10	typhoid	typhoid	NN
cord-023168-cd7adns8	50	11	and	and	CC
cord-023168-cd7adns8	50	12	paratyphoid	paratyphoid	NN
cord-023168-cd7adns8	50	13	fever	fever	NN
cord-023168-cd7adns8	50	14	from	from	IN
cord-023168-cd7adns8	50	15	pyogenic	pyogenic	JJ
cord-023168-cd7adns8	50	16	infections	infection	NNS
cord-023168-cd7adns8	50	17	.	.	.
cord-023168-cd7adns8	51	1	Neutropenia	neutropenia	NN
cord-023168-cd7adns8	51	2	is	be	VBZ
cord-023168-cd7adns8	51	3	defined	define	VBN
cord-023168-cd7adns8	51	4	as	as	IN
cord-023168-cd7adns8	51	5	an	an	DT
cord-023168-cd7adns8	51	6	absolute	absolute	JJ
cord-023168-cd7adns8	51	7	neutrophil	neutrophil	NN
cord-023168-cd7adns8	51	8	count	count	NN
cord-023168-cd7adns8	51	9	<	<	XX
cord-023168-cd7adns8	51	10	1.5	1.5	CD
cord-023168-cd7adns8	51	11	×	×	NN
cord-023168-cd7adns8	51	12	10	10	CD
cord-023168-cd7adns8	51	13	9	9	CD
cord-023168-cd7adns8	51	14	/L.	/L.	.
cord-023168-cd7adns8	52	1	It	-PRON-	PRP
cord-023168-cd7adns8	52	2	is	be	VBZ
cord-023168-cd7adns8	52	3	usually	usually	RB
cord-023168-cd7adns8	52	4	classified	classify	VBN
cord-023168-cd7adns8	52	5	into	into	IN
cord-023168-cd7adns8	52	6	severe	severe	JJ
cord-023168-cd7adns8	52	7	(	(	-LRB-
cord-023168-cd7adns8	52	8	<	<	NNP
cord-023168-cd7adns8	52	9	0.5	0.5	CD
cord-023168-cd7adns8	52	10	×	×	CD
cord-023168-cd7adns8	52	11	10	10	CD
cord-023168-cd7adns8	52	12	9	9	CD
cord-023168-cd7adns8	52	13	/L	/L	.
cord-023168-cd7adns8	52	14	)	)	-RRB-
cord-023168-cd7adns8	52	15	,	,	,
cord-023168-cd7adns8	52	16	moderate	moderate	JJ
cord-023168-cd7adns8	52	17	red	red	JJ
cord-023168-cd7adns8	52	18	cells	cell	NNS
cord-023168-cd7adns8	52	19	are	be	VBP
cord-023168-cd7adns8	52	20	released	release	VBN
cord-023168-cd7adns8	52	21	into	into	IN
cord-023168-cd7adns8	52	22	the	the	DT
cord-023168-cd7adns8	52	23	circulation	circulation	NN
cord-023168-cd7adns8	52	24	from	from	IN
cord-023168-cd7adns8	52	25	the	the	DT
cord-023168-cd7adns8	52	26	bone	bone	NN
cord-023168-cd7adns8	52	27	marrow	marrow	NN
cord-023168-cd7adns8	52	28	and	and	CC
cord-023168-cd7adns8	52	29	percolate	percolate	VB
cord-023168-cd7adns8	52	30	through	through	IN
cord-023168-cd7adns8	52	31	the	the	DT
cord-023168-cd7adns8	52	32	tissues	tissue	NNS
cord-023168-cd7adns8	52	33	and	and	CC
cord-023168-cd7adns8	52	34	organs	organ	NNS
cord-023168-cd7adns8	52	35	.	.	.
cord-023168-cd7adns8	53	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	53	2	can	can	MD
cord-023168-cd7adns8	53	3	result	result	VB
cord-023168-cd7adns8	53	4	from	from	IN
cord-023168-cd7adns8	53	5	defects	defect	NNS
cord-023168-cd7adns8	53	6	in	in	IN
cord-023168-cd7adns8	53	7	any	any	DT
cord-023168-cd7adns8	53	8	of	of	IN
cord-023168-cd7adns8	53	9	these	these	DT
cord-023168-cd7adns8	53	10	stages	stage	NNS
cord-023168-cd7adns8	53	11	.	.	.
cord-023168-cd7adns8	54	1	Inadequate	inadequate	JJ
cord-023168-cd7adns8	54	2	production	production	NN
cord-023168-cd7adns8	54	3	of	of	IN
cord-023168-cd7adns8	54	4	red	red	JJ
cord-023168-cd7adns8	54	5	cells	cell	NNS
cord-023168-cd7adns8	54	6	in	in	IN
cord-023168-cd7adns8	54	7	the	the	DT
cord-023168-cd7adns8	54	8	bone	bone	NN
cord-023168-cd7adns8	54	9	marrow	marrow	NN
cord-023168-cd7adns8	54	10	can	can	MD
cord-023168-cd7adns8	54	11	be	be	VB
cord-023168-cd7adns8	54	12	due	due	JJ
cord-023168-cd7adns8	54	13	to	to	IN
cord-023168-cd7adns8	54	14	lack	lack	NN
cord-023168-cd7adns8	54	15	of	of	IN
cord-023168-cd7adns8	54	16	nutrients	nutrient	NNS
cord-023168-cd7adns8	54	17	(	(	-LRB-
cord-023168-cd7adns8	54	18	e.g.	e.g.	RB
cord-023168-cd7adns8	54	19	iron	iron	NN
cord-023168-cd7adns8	54	20	,	,	,
cord-023168-cd7adns8	54	21	B	B	NNP
cord-023168-cd7adns8	54	22	12	12	CD
cord-023168-cd7adns8	54	23	,	,	,
cord-023168-cd7adns8	54	24	folate	folate	NN
cord-023168-cd7adns8	54	25	,	,	,
cord-023168-cd7adns8	54	26	vitamin	vitamin	NN
cord-023168-cd7adns8	54	27	A	a	NN
cord-023168-cd7adns8	54	28	,	,	,
cord-023168-cd7adns8	54	29	copper	copper	NN
cord-023168-cd7adns8	54	30	or	or	CC
cord-023168-cd7adns8	54	31	zinc	zinc	NN
cord-023168-cd7adns8	54	32	)	)	-RRB-
cord-023168-cd7adns8	54	33	,	,	,
cord-023168-cd7adns8	54	34	abnormal	abnormal	JJ
cord-023168-cd7adns8	54	35	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	54	36	synthesis	synthesis	NN
cord-023168-cd7adns8	54	37	(	(	-LRB-
cord-023168-cd7adns8	54	38	i.e.	i.e.	FW
cord-023168-cd7adns8	54	39	haemoglobinopathies	haemoglobinopathies	NNP
cord-023168-cd7adns8	54	40	)	)	-RRB-
cord-023168-cd7adns8	54	41	or	or	CC
cord-023168-cd7adns8	54	42	ineffective	ineffective	JJ
cord-023168-cd7adns8	54	43	erythropoeisis	erythropoeisis	NN
cord-023168-cd7adns8	54	44	from	from	IN
cord-023168-cd7adns8	54	45	myelodysplasia	myelodysplasia	NNP
cord-023168-cd7adns8	54	46	or	or	CC
cord-023168-cd7adns8	54	47	infections	infection	NNS
cord-023168-cd7adns8	54	48	.	.	.
cord-023168-cd7adns8	55	1	Red	red	JJ
cord-023168-cd7adns8	55	2	cells	cell	NNS
cord-023168-cd7adns8	55	3	can	can	MD
cord-023168-cd7adns8	55	4	be	be	VB
cord-023168-cd7adns8	55	5	lost	lose	VBN
cord-023168-cd7adns8	55	6	from	from	IN
cord-023168-cd7adns8	55	7	the	the	DT
cord-023168-cd7adns8	55	8	body	body	NN
cord-023168-cd7adns8	55	9	(	(	-LRB-
cord-023168-cd7adns8	55	10	e.g.	e.g.	DT
cord-023168-cd7adns8	55	11	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	55	12	bleeding	bleeding	NN
cord-023168-cd7adns8	55	13	)	)	-RRB-
cord-023168-cd7adns8	55	14	or	or	CC
cord-023168-cd7adns8	55	15	removed	remove	VBN
cord-023168-cd7adns8	55	16	prematurely	prematurely	RB
cord-023168-cd7adns8	55	17	if	if	IN
cord-023168-cd7adns8	55	18	they	-PRON-	PRP
cord-023168-cd7adns8	55	19	are	be	VBP
cord-023168-cd7adns8	55	20	abnormal	abnormal	JJ
cord-023168-cd7adns8	55	21	or	or	CC
cord-023168-cd7adns8	55	22	the	the	DT
cord-023168-cd7adns8	55	23	spleen	spleen	NN
cord-023168-cd7adns8	55	24	is	be	VBZ
cord-023168-cd7adns8	55	25	enlarged	enlarge	VBN
cord-023168-cd7adns8	55	26	(	(	-LRB-
cord-023168-cd7adns8	55	27	i.e.	i.e.	FW
cord-023168-cd7adns8	55	28	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	55	29	)	)	-RRB-
cord-023168-cd7adns8	55	30	.	.	.
cord-023168-cd7adns8	56	1	Kidney	kidney	NN
cord-023168-cd7adns8	56	2	disease	disease	NN
cord-023168-cd7adns8	56	3	can	can	MD
cord-023168-cd7adns8	56	4	result	result	VB
cord-023168-cd7adns8	56	5	in	in	IN
cord-023168-cd7adns8	56	6	decreased	decreased	JJ
cord-023168-cd7adns8	56	7	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	56	8	.	.	.
cord-023168-cd7adns8	57	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	57	2	of	of	IN
cord-023168-cd7adns8	57	3	chronic	chronic	JJ
cord-023168-cd7adns8	57	4	disease	disease	NN
cord-023168-cd7adns8	57	5	(	(	-LRB-
cord-023168-cd7adns8	57	6	or	or	CC
cord-023168-cd7adns8	57	7	'	'	``
cord-023168-cd7adns8	57	8	anaemia	anaemia	NN
cord-023168-cd7adns8	57	9	of	of	IN
cord-023168-cd7adns8	57	10	inflammation	inflammation	NN
cord-023168-cd7adns8	57	11	'	'	''
cord-023168-cd7adns8	57	12	)	)	-RRB-
cord-023168-cd7adns8	57	13	is	be	VBZ
cord-023168-cd7adns8	57	14	due	due	JJ
cord-023168-cd7adns8	57	15	to	to	IN
cord-023168-cd7adns8	57	16	an	an	DT
cord-023168-cd7adns8	57	17	inadequate	inadequate	JJ
cord-023168-cd7adns8	57	18	response	response	NN
cord-023168-cd7adns8	57	19	to	to	IN
cord-023168-cd7adns8	57	20	erythropoieitin	erythropoieitin	NNP
cord-023168-cd7adns8	57	21	or	or	CC
cord-023168-cd7adns8	57	22	to	to	TO
cord-023168-cd7adns8	57	23	increased	increase	VBN
cord-023168-cd7adns8	57	24	cytokine	cytokine	NN
cord-023168-cd7adns8	57	25	-	-	HYPH
cord-023168-cd7adns8	57	26	induced	induce	VBN
cord-023168-cd7adns8	57	27	hepcidin	hepcidin	NNP
cord-023168-cd7adns8	57	28	release	release	NN
cord-023168-cd7adns8	57	29	in	in	IN
cord-023168-cd7adns8	57	30	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	57	31	states	state	NNS
cord-023168-cd7adns8	57	32	which	which	WDT
cord-023168-cd7adns8	57	33	interferes	interfere	VBZ
cord-023168-cd7adns8	57	34	with	with	IN
cord-023168-cd7adns8	57	35	iron	iron	NN
cord-023168-cd7adns8	57	36	absorption	absorption	NN
cord-023168-cd7adns8	57	37	or	or	CC
cord-023168-cd7adns8	57	38	iron	iron	NN
cord-023168-cd7adns8	57	39	utilization	utilization	NN
cord-023168-cd7adns8	57	40	.	.	.
cord-023168-cd7adns8	58	1	Diagnostic	diagnostic	JJ
cord-023168-cd7adns8	58	2	algorithms	algorithm	NNS
cord-023168-cd7adns8	58	3	to	to	TO
cord-023168-cd7adns8	58	4	determine	determine	VB
cord-023168-cd7adns8	58	5	the	the	DT
cord-023168-cd7adns8	58	6	cause	cause	NN
cord-023168-cd7adns8	58	7	of	of	IN
cord-023168-cd7adns8	58	8	anaemia	anaemia	NN
cord-023168-cd7adns8	58	9	are	be	VBP
cord-023168-cd7adns8	58	10	usually	usually	RB
cord-023168-cd7adns8	58	11	based	base	VBN
cord-023168-cd7adns8	58	12	on	on	IN
cord-023168-cd7adns8	58	13	a	a	DT
cord-023168-cd7adns8	58	14	combination	combination	NN
cord-023168-cd7adns8	58	15	of	of	IN
cord-023168-cd7adns8	58	16	the	the	DT
cord-023168-cd7adns8	58	17	mean	mean	JJ
cord-023168-cd7adns8	58	18	cell	cell	NN
cord-023168-cd7adns8	58	19	volume	volume	NN
cord-023168-cd7adns8	58	20	of	of	IN
cord-023168-cd7adns8	58	21	the	the	DT
cord-023168-cd7adns8	58	22	red	red	JJ
cord-023168-cd7adns8	58	23	cells	cell	NNS
cord-023168-cd7adns8	58	24	,	,	,
cord-023168-cd7adns8	58	25	the	the	DT
cord-023168-cd7adns8	58	26	reticulocyte	reticulocyte	NNP
cord-023168-cd7adns8	58	27	count	count	NN
cord-023168-cd7adns8	58	28	and	and	CC
cord-023168-cd7adns8	58	29	blood	blood	NN
cord-023168-cd7adns8	58	30	film	film	NN
cord-023168-cd7adns8	58	31	appearance	appearance	NN
cord-023168-cd7adns8	58	32	(	(	-LRB-
cord-023168-cd7adns8	58	33	Figures	figure	NNS
cord-023168-cd7adns8	58	34	65.2	65.2	CD
cord-023168-cd7adns8	58	35	,	,	,
cord-023168-cd7adns8	58	36	65.3	65.3	CD
cord-023168-cd7adns8	58	37	)	)	-RRB-
cord-023168-cd7adns8	58	38	.	.	.
cord-023168-cd7adns8	59	1	This	this	DT
cord-023168-cd7adns8	59	2	approach	approach	NN
cord-023168-cd7adns8	59	3	is	be	VBZ
cord-023168-cd7adns8	59	4	based	base	VBN
cord-023168-cd7adns8	59	5	on	on	IN
cord-023168-cd7adns8	59	6	the	the	DT
cord-023168-cd7adns8	59	7	availability	availability	NN
cord-023168-cd7adns8	59	8	of	of	IN
cord-023168-cd7adns8	59	9	a	a	DT
cord-023168-cd7adns8	59	10	haematology	haematology	NN
cord-023168-cd7adns8	59	11	analyser	analyser	NN
cord-023168-cd7adns8	59	12	and	and	CC
cord-023168-cd7adns8	59	13	an	an	DT
cord-023168-cd7adns8	59	14	experienced	experienced	JJ
cord-023168-cd7adns8	59	15	microscopist	microscopist	NN
cord-023168-cd7adns8	59	16	.	.	.
cord-023168-cd7adns8	60	1	Several	several	JJ
cord-023168-cd7adns8	60	2	conditions	condition	NNS
cord-023168-cd7adns8	60	3	which	which	WDT
cord-023168-cd7adns8	60	4	cause	cause	VBP
cord-023168-cd7adns8	60	5	anaemia	anaemia	NN
cord-023168-cd7adns8	60	6	may	may	MD
cord-023168-cd7adns8	60	7	co	co	VB
cord-023168-cd7adns8	60	8	-	-	VB
cord-023168-cd7adns8	60	9	exist	exist	VB
cord-023168-cd7adns8	60	10	in	in	IN
cord-023168-cd7adns8	60	11	the	the	DT
cord-023168-cd7adns8	60	12	same	same	JJ
cord-023168-cd7adns8	60	13	individual	individual	NN
cord-023168-cd7adns8	60	14	(	(	-LRB-
cord-023168-cd7adns8	60	15	e.g.	e.g.	IN
cord-023168-cd7adns8	60	16	intestinal	intestinal	JJ
cord-023168-cd7adns8	60	17	parasites	parasite	NNS
cord-023168-cd7adns8	60	18	,	,	,
cord-023168-cd7adns8	60	19	malaria	malaria	NN
cord-023168-cd7adns8	60	20	and	and	CC
cord-023168-cd7adns8	60	21	sickle	sickle	NN
cord-023168-cd7adns8	60	22	cell	cell	NN
cord-023168-cd7adns8	60	23	disease	disease	NN
cord-023168-cd7adns8	60	24	)	)	-RRB-
cord-023168-cd7adns8	60	25	and	and	CC
cord-023168-cd7adns8	60	26	hence	hence	RB
cord-023168-cd7adns8	60	27	a	a	DT
cord-023168-cd7adns8	60	28	thorough	thorough	JJ
cord-023168-cd7adns8	60	29	investigation	investigation	NN
cord-023168-cd7adns8	60	30	is	be	VBZ
cord-023168-cd7adns8	60	31	crucial	crucial	JJ
cord-023168-cd7adns8	60	32	to	to	TO
cord-023168-cd7adns8	60	33	identify	identify	VB
cord-023168-cd7adns8	60	34	all	all	DT
cord-023168-cd7adns8	60	35	potential	potential	JJ
cord-023168-cd7adns8	60	36	causes	cause	NNS
cord-023168-cd7adns8	60	37	of	of	IN
cord-023168-cd7adns8	60	38	anaemia	anaemia	NN
cord-023168-cd7adns8	60	39	.	.	.
cord-023168-cd7adns8	61	1	Neutrophils	neutrophils	NN
cord-023168-cd7adns8	61	2	released	release	VBN
cord-023168-cd7adns8	61	3	from	from	IN
cord-023168-cd7adns8	61	4	the	the	DT
cord-023168-cd7adns8	61	5	marrow	marrow	NN
cord-023168-cd7adns8	61	6	after	after	IN
cord-023168-cd7adns8	61	7	maturation	maturation	NN
cord-023168-cd7adns8	61	8	can	can	MD
cord-023168-cd7adns8	61	9	either	either	CC
cord-023168-cd7adns8	61	10	enter	enter	VB
cord-023168-cd7adns8	61	11	the	the	DT
cord-023168-cd7adns8	61	12	'	'	``
cord-023168-cd7adns8	61	13	circulating	circulate	VBG
cord-023168-cd7adns8	61	14	pool	pool	NN
cord-023168-cd7adns8	61	15	'	'	''
cord-023168-cd7adns8	61	16	or	or	CC
cord-023168-cd7adns8	61	17	they	-PRON-	PRP
cord-023168-cd7adns8	61	18	can	can	MD
cord-023168-cd7adns8	61	19	remain	remain	VB
cord-023168-cd7adns8	61	20	in	in	IN
cord-023168-cd7adns8	61	21	the	the	DT
cord-023168-cd7adns8	61	22	'	'	``
cord-023168-cd7adns8	61	23	marginal	marginal	JJ
cord-023168-cd7adns8	61	24	pool	pool	NN
cord-023168-cd7adns8	61	25	'	'	''
cord-023168-cd7adns8	61	26	where	where	WRB
cord-023168-cd7adns8	61	27	they	-PRON-	PRP
cord-023168-cd7adns8	61	28	are	be	VBP
cord-023168-cd7adns8	61	29	loosely	loosely	RB
cord-023168-cd7adns8	61	30	attached	attach	VBN
cord-023168-cd7adns8	61	31	to	to	IN
cord-023168-cd7adns8	61	32	the	the	DT
cord-023168-cd7adns8	61	33	blood	blood	NN
cord-023168-cd7adns8	61	34	vessel	vessel	NN
cord-023168-cd7adns8	61	35	wall	wall	NN
cord-023168-cd7adns8	61	36	.	.	.
cord-023168-cd7adns8	62	1	Cells	cell	NNS
cord-023168-cd7adns8	62	2	in	in	IN
cord-023168-cd7adns8	62	3	the	the	DT
cord-023168-cd7adns8	62	4	marginal	marginal	JJ
cord-023168-cd7adns8	62	5	pool	pool	NN
cord-023168-cd7adns8	62	6	are	be	VBP
cord-023168-cd7adns8	62	7	not	not	RB
cord-023168-cd7adns8	62	8	sampled	sample	VBN
cord-023168-cd7adns8	62	9	when	when	WRB
cord-023168-cd7adns8	62	10	blood	blood	NN
cord-023168-cd7adns8	62	11	is	be	VBZ
cord-023168-cd7adns8	62	12	taken	take	VBN
cord-023168-cd7adns8	62	13	for	for	IN
cord-023168-cd7adns8	62	14	a	a	DT
cord-023168-cd7adns8	62	15	full	full	JJ
cord-023168-cd7adns8	62	16	blood	blood	NN
cord-023168-cd7adns8	62	17	count	count	NN
cord-023168-cd7adns8	62	18	.	.	.
cord-023168-cd7adns8	63	1	1	1	LS
cord-023168-cd7adns8	64	1	Neutrophilia	Neutrophilia	NNP
cord-023168-cd7adns8	64	2	can	can	MD
cord-023168-cd7adns8	64	3	therefore	therefore	RB
cord-023168-cd7adns8	64	4	result	result	VB
cord-023168-cd7adns8	64	5	from	from	IN
cord-023168-cd7adns8	64	6	increased	increase	VBN
cord-023168-cd7adns8	64	7	bone	bone	NN
cord-023168-cd7adns8	64	8	marrow	marrow	NN
cord-023168-cd7adns8	64	9	synthesis	synthesis	NN
cord-023168-cd7adns8	64	10	and	and	CC
cord-023168-cd7adns8	64	11	also	also	RB
cord-023168-cd7adns8	64	12	from	from	IN
cord-023168-cd7adns8	64	13	decreased	decrease	VBN
cord-023168-cd7adns8	64	14	margination	margination	NN
cord-023168-cd7adns8	64	15	which	which	WDT
cord-023168-cd7adns8	64	16	increases	increase	VBZ
cord-023168-cd7adns8	64	17	the	the	DT
cord-023168-cd7adns8	64	18	circulating	circulate	VBG
cord-023168-cd7adns8	64	19	pool	pool	NN
cord-023168-cd7adns8	64	20	.	.	.
cord-023168-cd7adns8	65	1	There	there	EX
cord-023168-cd7adns8	65	2	are	be	VBP
cord-023168-cd7adns8	65	3	many	many	JJ
cord-023168-cd7adns8	65	4	causes	cause	NNS
cord-023168-cd7adns8	65	5	of	of	IN
cord-023168-cd7adns8	65	6	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	65	7	(	(	-LRB-
cord-023168-cd7adns8	65	8	Box	Box	NNP
cord-023168-cd7adns8	65	9	65.1	65.1	CD
cord-023168-cd7adns8	65	10	)	)	-RRB-
cord-023168-cd7adns8	65	11	but	but	CC
cord-023168-cd7adns8	65	12	the	the	DT
cord-023168-cd7adns8	65	13	commonest	common	JJS
cord-023168-cd7adns8	65	14	is	be	VBZ
cord-023168-cd7adns8	65	15	bacterial	bacterial	JJ
cord-023168-cd7adns8	65	16	infection	infection	NN
cord-023168-cd7adns8	65	17	in	in	IN
cord-023168-cd7adns8	65	18	which	which	WDT
cord-023168-cd7adns8	65	19	there	there	EX
cord-023168-cd7adns8	65	20	is	be	VBZ
cord-023168-cd7adns8	65	21	increased	increase	VBN
cord-023168-cd7adns8	65	22	bone	bone	NN
cord-023168-cd7adns8	65	23	marrow	marrow	NN
cord-023168-cd7adns8	65	24	production	production	NN
cord-023168-cd7adns8	65	25	of	of	IN
cord-023168-cd7adns8	65	26	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	65	27	and	and	CC
cord-023168-cd7adns8	65	28	release	release	NN
cord-023168-cd7adns8	65	29	of	of	IN
cord-023168-cd7adns8	65	30	neutrophil	neutrophil	NN
cord-023168-cd7adns8	65	31	precursors	precursor	NNS
cord-023168-cd7adns8	65	32	into	into	IN
cord-023168-cd7adns8	65	33	the	the	DT
cord-023168-cd7adns8	65	34	peripheral	peripheral	JJ
cord-023168-cd7adns8	65	35	blood	blood	NN
cord-023168-cd7adns8	65	36	.	.	.
cord-023168-cd7adns8	66	1	This	this	DT
cord-023168-cd7adns8	66	2	'	'	``
cord-023168-cd7adns8	66	3	leukaemoid	leukaemoid	NN
cord-023168-cd7adns8	66	4	(	(	-LRB-
cord-023168-cd7adns8	66	5	0.5	0.5	CD
cord-023168-cd7adns8	66	6	-	-	SYM
cord-023168-cd7adns8	66	7	1.0	1.0	CD
cord-023168-cd7adns8	66	8	×	×	NN
cord-023168-cd7adns8	66	9	10	10	CD
cord-023168-cd7adns8	66	10	9	9	CD
cord-023168-cd7adns8	66	11	/L	/L	.
cord-023168-cd7adns8	66	12	)	)	-RRB-
cord-023168-cd7adns8	66	13	or	or	CC
cord-023168-cd7adns8	66	14	mild	mild	JJ
cord-023168-cd7adns8	66	15	(	(	-LRB-
cord-023168-cd7adns8	66	16	1.0	1.0	CD
cord-023168-cd7adns8	66	17	-	-	SYM
cord-023168-cd7adns8	66	18	1.5	1.5	CD
cord-023168-cd7adns8	66	19	×	×	NN
cord-023168-cd7adns8	66	20	10	10	CD
cord-023168-cd7adns8	66	21	9	9	CD
cord-023168-cd7adns8	66	22	/L	/L	.
cord-023168-cd7adns8	66	23	)	)	-RRB-
cord-023168-cd7adns8	66	24	.	.	.
cord-023168-cd7adns8	67	1	The	the	DT
cord-023168-cd7adns8	67	2	propensity	propensity	NN
cord-023168-cd7adns8	67	3	to	to	TO
cord-023168-cd7adns8	67	4	develop	develop	VB
cord-023168-cd7adns8	67	5	infections	infection	NNS
cord-023168-cd7adns8	67	6	is	be	VBZ
cord-023168-cd7adns8	67	7	related	relate	VBN
cord-023168-cd7adns8	67	8	to	to	IN
cord-023168-cd7adns8	67	9	the	the	DT
cord-023168-cd7adns8	67	10	degree	degree	NN
cord-023168-cd7adns8	67	11	and	and	CC
cord-023168-cd7adns8	67	12	duration	duration	NN
cord-023168-cd7adns8	67	13	of	of	IN
cord-023168-cd7adns8	67	14	neutropenia	neutropenia	NN
cord-023168-cd7adns8	67	15	,	,	,
cord-023168-cd7adns8	67	16	with	with	IN
cord-023168-cd7adns8	67	17	higher	high	JJR
cord-023168-cd7adns8	67	18	risk	risk	NN
cord-023168-cd7adns8	67	19	associated	associate	VBN
cord-023168-cd7adns8	67	20	with	with	IN
cord-023168-cd7adns8	67	21	counts	count	NNS
cord-023168-cd7adns8	67	22	below	below	IN
cord-023168-cd7adns8	67	23	0.5	0.5	CD
cord-023168-cd7adns8	67	24	×	×	CD
cord-023168-cd7adns8	67	25	10	10	CD
cord-023168-cd7adns8	67	26	9	9	CD
cord-023168-cd7adns8	68	1	/L.	/L.	NFP
cord-023168-cd7adns8	68	2	Africans	Africans	NNPS
cord-023168-cd7adns8	68	3	,	,	,
cord-023168-cd7adns8	68	4	African	African	NNPS
cord-023168-cd7adns8	68	5	Americans	Americans	NNPS
cord-023168-cd7adns8	68	6	,	,	,
cord-023168-cd7adns8	68	7	Yemenite	Yemenite	NNPS
cord-023168-cd7adns8	68	8	Jews	Jews	NNPS
cord-023168-cd7adns8	68	9	,	,	,
cord-023168-cd7adns8	68	10	Palestinians	Palestinians	NNPS
cord-023168-cd7adns8	68	11	and	and	CC
cord-023168-cd7adns8	68	12	Saudi	Saudi	NNP
cord-023168-cd7adns8	68	13	Arabians	Arabians	NNPS
cord-023168-cd7adns8	68	14	generally	generally	RB
cord-023168-cd7adns8	68	15	have	have	VBP
cord-023168-cd7adns8	68	16	slightly	slightly	RB
cord-023168-cd7adns8	68	17	lower	low	JJR
cord-023168-cd7adns8	68	18	neutrophil	neutrophil	NN
cord-023168-cd7adns8	68	19	counts	count	NNS
cord-023168-cd7adns8	68	20	compared	compare	VBN
cord-023168-cd7adns8	68	21	with	with	IN
cord-023168-cd7adns8	68	22	other	other	JJ
cord-023168-cd7adns8	68	23	races	race	NNS
cord-023168-cd7adns8	68	24	.	.	.
cord-023168-cd7adns8	69	1	This	this	DT
cord-023168-cd7adns8	69	2	is	be	VBZ
cord-023168-cd7adns8	69	3	thought	think	VBN
cord-023168-cd7adns8	69	4	to	to	TO
cord-023168-cd7adns8	69	5	be	be	VB
cord-023168-cd7adns8	69	6	due	due	JJ
cord-023168-cd7adns8	69	7	to	to	IN
cord-023168-cd7adns8	69	8	an	an	DT
cord-023168-cd7adns8	69	9	increase	increase	NN
cord-023168-cd7adns8	69	10	in	in	IN
cord-023168-cd7adns8	69	11	the	the	DT
cord-023168-cd7adns8	69	12	bone	bone	NN
cord-023168-cd7adns8	69	13	marrow	marrow	NN
cord-023168-cd7adns8	69	14	storage	storage	NN
cord-023168-cd7adns8	69	15	pool	pool	NN
cord-023168-cd7adns8	69	16	as	as	IN
cord-023168-cd7adns8	69	17	ethnic	ethnic	JJ
cord-023168-cd7adns8	69	18	neutropenia	neutropenia	NN
cord-023168-cd7adns8	69	19	is	be	VBZ
cord-023168-cd7adns8	69	20	associated	associate	VBN
cord-023168-cd7adns8	69	21	with	with	IN
cord-023168-cd7adns8	69	22	good	good	JJ
cord-023168-cd7adns8	69	23	neutrophil	neutrophil	NN
cord-023168-cd7adns8	69	24	responses	response	NNS
cord-023168-cd7adns8	69	25	to	to	IN
cord-023168-cd7adns8	69	26	infections	infection	NNS
cord-023168-cd7adns8	69	27	.	.	.
cord-023168-cd7adns8	70	1	Neutropenia	neutropenia	NN
cord-023168-cd7adns8	70	2	can	can	MD
cord-023168-cd7adns8	70	3	be	be	VB
cord-023168-cd7adns8	70	4	due	due	JJ
cord-023168-cd7adns8	70	5	to	to	IN
cord-023168-cd7adns8	70	6	impaired	impaired	JJ
cord-023168-cd7adns8	70	7	or	or	CC
cord-023168-cd7adns8	70	8	ineffective	ineffective	JJ
cord-023168-cd7adns8	70	9	(	(	-LRB-
cord-023168-cd7adns8	70	10	intramedullary	intramedullary	JJ
cord-023168-cd7adns8	70	11	death	death	NN
cord-023168-cd7adns8	70	12	of	of	IN
cord-023168-cd7adns8	70	13	neutrophil	neutrophil	NN
cord-023168-cd7adns8	70	14	precursors	precursor	NNS
cord-023168-cd7adns8	70	15	despite	despite	IN
cord-023168-cd7adns8	70	16	normal	normal	JJ
cord-023168-cd7adns8	70	17	bone	bone	NN
cord-023168-cd7adns8	70	18	marrow	marrow	NN
cord-023168-cd7adns8	70	19	production	production	NN
cord-023168-cd7adns8	70	20	)	)	-RRB-
cord-023168-cd7adns8	70	21	synthesis	synthesis	NN
cord-023168-cd7adns8	70	22	by	by	IN
cord-023168-cd7adns8	70	23	the	the	DT
cord-023168-cd7adns8	70	24	bone	bone	NN
cord-023168-cd7adns8	70	25	marrow	marrow	NN
cord-023168-cd7adns8	70	26	(	(	-LRB-
cord-023168-cd7adns8	70	27	e.g.	e.g.	IN
cord-023168-cd7adns8	70	28	myelodysplasia	myelodysplasia	NNP
cord-023168-cd7adns8	70	29	,	,	,
cord-023168-cd7adns8	70	30	megaloblastic	megaloblastic	JJ
cord-023168-cd7adns8	70	31	anaemia	anaemia	NN
cord-023168-cd7adns8	70	32	,	,	,
cord-023168-cd7adns8	70	33	treatment	treatment	NN
cord-023168-cd7adns8	70	34	with	with	IN
cord-023168-cd7adns8	70	35	phenytoin	phenytoin	NN
cord-023168-cd7adns8	70	36	or	or	CC
cord-023168-cd7adns8	70	37	methotrexate	methotrexate	NNP
cord-023168-cd7adns8	70	38	)	)	-RRB-
cord-023168-cd7adns8	70	39	;	;	:
cord-023168-cd7adns8	70	40	a	a	DT
cord-023168-cd7adns8	70	41	shift	shift	NN
cord-023168-cd7adns8	70	42	from	from	IN
cord-023168-cd7adns8	70	43	the	the	DT
cord-023168-cd7adns8	70	44	circulating	circulate	VBG
cord-023168-cd7adns8	70	45	pool	pool	NN
cord-023168-cd7adns8	70	46	to	to	IN
cord-023168-cd7adns8	70	47	marginated	marginate	VBN
cord-023168-cd7adns8	70	48	pool	pool	NN
cord-023168-cd7adns8	70	49	(	(	-LRB-
cord-023168-cd7adns8	70	50	pseudoneutropenia	pseudoneutropenia	NNP
cord-023168-cd7adns8	70	51	)	)	-RRB-
cord-023168-cd7adns8	70	52	and	and	CC
cord-023168-cd7adns8	70	53	increased	increase	VBN
cord-023168-cd7adns8	70	54	peripheral	peripheral	JJ
cord-023168-cd7adns8	70	55	destruction	destruction	NN
cord-023168-cd7adns8	70	56	(	(	-LRB-
cord-023168-cd7adns8	70	57	e.g.	e.g.	RB
cord-023168-cd7adns8	70	58	secondary	secondary	JJ
cord-023168-cd7adns8	70	59	to	to	IN
cord-023168-cd7adns8	70	60	antibodies	antibody	NNS
cord-023168-cd7adns8	70	61	against	against	IN
cord-023168-cd7adns8	70	62	the	the	DT
cord-023168-cd7adns8	70	63	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	70	64	or	or	CC
cord-023168-cd7adns8	70	65	increased	increase	VBN
cord-023168-cd7adns8	70	66	reticulo	reticulo	NN
cord-023168-cd7adns8	70	67	-	-	HYPH
cord-023168-cd7adns8	70	68	endothelial	endothelial	JJ
cord-023168-cd7adns8	70	69	activity	activity	NN
cord-023168-cd7adns8	70	70	in	in	IN
cord-023168-cd7adns8	70	71	sepsis	sepsis	NN
cord-023168-cd7adns8	70	72	or	or	CC
cord-023168-cd7adns8	70	73	haemophagocytic	haemophagocytic	JJ
cord-023168-cd7adns8	70	74	syndrome	syndrome	NN
cord-023168-cd7adns8	70	75	)	)	-RRB-
cord-023168-cd7adns8	70	76	(	(	-LRB-
cord-023168-cd7adns8	70	77	Box	Box	NNP
cord-023168-cd7adns8	70	78	65.2	65.2	CD
cord-023168-cd7adns8	70	79	)	)	-RRB-
cord-023168-cd7adns8	70	80	.	.	.
cord-023168-cd7adns8	71	1	Increased	increase	VBN
cord-023168-cd7adns8	71	2	consumption	consumption	NN
cord-023168-cd7adns8	71	3	of	of	IN
cord-023168-cd7adns8	71	4	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	71	5	can	can	MD
cord-023168-cd7adns8	71	6	result	result	VB
cord-023168-cd7adns8	71	7	from	from	IN
cord-023168-cd7adns8	71	8	increased	increase	VBN
cord-023168-cd7adns8	71	9	attachment	attachment	NN
cord-023168-cd7adns8	71	10	of	of	IN
cord-023168-cd7adns8	71	11	cells	cell	NNS
cord-023168-cd7adns8	71	12	to	to	IN
cord-023168-cd7adns8	71	13	endothelium	endothelium	NN
cord-023168-cd7adns8	71	14	or	or	CC
cord-023168-cd7adns8	71	15	other	other	JJ
cord-023168-cd7adns8	71	16	leukocytes	leukocyte	NNS
cord-023168-cd7adns8	71	17	in	in	IN
cord-023168-cd7adns8	71	18	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	71	19	states	state	NNS
cord-023168-cd7adns8	71	20	.	.	.
cord-023168-cd7adns8	72	1	Neutropenia	neutropenia	NN
cord-023168-cd7adns8	72	2	is	be	VBZ
cord-023168-cd7adns8	72	3	often	often	RB
cord-023168-cd7adns8	72	4	the	the	DT
cord-023168-cd7adns8	72	5	result	result	NN
cord-023168-cd7adns8	72	6	of	of	IN
cord-023168-cd7adns8	72	7	a	a	DT
cord-023168-cd7adns8	72	8	combination	combination	NN
cord-023168-cd7adns8	72	9	of	of	IN
cord-023168-cd7adns8	72	10	several	several	JJ
cord-023168-cd7adns8	72	11	of	of	IN
cord-023168-cd7adns8	72	12	these	these	DT
cord-023168-cd7adns8	72	13	mechanisms	mechanism	NNS
cord-023168-cd7adns8	72	14	.	.	.
cord-023168-cd7adns8	73	1	Infants	infant	NNS
cord-023168-cd7adns8	73	2	of	of	IN
cord-023168-cd7adns8	73	3	hypertensive	hypertensive	JJ
cord-023168-cd7adns8	73	4	mothers	mother	NNS
cord-023168-cd7adns8	73	5	may	may	MD
cord-023168-cd7adns8	73	6	have	have	VB
cord-023168-cd7adns8	73	7	moderate	moderate	JJ
cord-023168-cd7adns8	73	8	to	to	IN
cord-023168-cd7adns8	73	9	severe	severe	JJ
cord-023168-cd7adns8	73	10	neutropenia	neutropenia	NN
cord-023168-cd7adns8	73	11	,	,	,
cord-023168-cd7adns8	73	12	which	which	WDT
cord-023168-cd7adns8	73	13	can	can	MD
cord-023168-cd7adns8	73	14	last	last	VB
cord-023168-cd7adns8	73	15	for	for	IN
cord-023168-cd7adns8	73	16	several	several	JJ
cord-023168-cd7adns8	73	17	days	day	NNS
cord-023168-cd7adns8	73	18	.	.	.
cord-023168-cd7adns8	74	1	This	this	DT
cord-023168-cd7adns8	74	2	is	be	VBZ
cord-023168-cd7adns8	74	3	probably	probably	RB
cord-023168-cd7adns8	74	4	related	relate	VBN
cord-023168-cd7adns8	74	5	to	to	IN
cord-023168-cd7adns8	74	6	bone	bone	NN
cord-023168-cd7adns8	74	7	marrow	marrow	NN
cord-023168-cd7adns8	74	8	suppression	suppression	NN
cord-023168-cd7adns8	74	9	.	.	.
cord-023168-cd7adns8	75	1	Moderate	moderate	JJ
cord-023168-cd7adns8	75	2	to	to	IN
cord-023168-cd7adns8	75	3	severe	severe	JJ
cord-023168-cd7adns8	75	4	neutropenia	neutropenia	NN
cord-023168-cd7adns8	75	5	can	can	MD
cord-023168-cd7adns8	75	6	also	also	RB
cord-023168-cd7adns8	75	7	occur	occur	VB
cord-023168-cd7adns8	75	8	in	in	IN
cord-023168-cd7adns8	75	9	newborn	newborn	JJ
cord-023168-cd7adns8	75	10	infants	infant	NNS
cord-023168-cd7adns8	75	11	as	as	IN
cord-023168-cd7adns8	75	12	a	a	DT
cord-023168-cd7adns8	75	13	result	result	NN
cord-023168-cd7adns8	75	14	of	of	IN
cord-023168-cd7adns8	75	15	the	the	DT
cord-023168-cd7adns8	75	16	transfer	transfer	NN
cord-023168-cd7adns8	75	17	of	of	IN
cord-023168-cd7adns8	75	18	maternal	maternal	JJ
cord-023168-cd7adns8	75	19	IgG	IgG	NNP
cord-023168-cd7adns8	75	20	anti	anti	JJ
cord-023168-cd7adns8	75	21	-	-	JJ
cord-023168-cd7adns8	75	22	neutrophil	neutrophil	JJ
cord-023168-cd7adns8	75	23	antibodies	antibody	NNS
cord-023168-cd7adns8	75	24	in	in	IN
cord-023168-cd7adns8	75	25	a	a	DT
cord-023168-cd7adns8	75	26	manner	manner	NN
cord-023168-cd7adns8	75	27	similar	similar	JJ
cord-023168-cd7adns8	75	28	to	to	IN
cord-023168-cd7adns8	75	29	rhesus	rhesu	NNS
cord-023168-cd7adns8	75	30	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	75	31	disease	disease	NN
cord-023168-cd7adns8	75	32	of	of	IN
cord-023168-cd7adns8	75	33	the	the	DT
cord-023168-cd7adns8	75	34	newborn	newborn	NN
cord-023168-cd7adns8	75	35	.	.	.
cord-023168-cd7adns8	76	1	4	4	LS
cord-023168-cd7adns8	77	1	Although	although	IN
cord-023168-cd7adns8	77	2	neutropenia	neutropenia	NN
cord-023168-cd7adns8	77	3	has	have	VBZ
cord-023168-cd7adns8	77	4	been	be	VBN
cord-023168-cd7adns8	77	5	described	describe	VBN
cord-023168-cd7adns8	77	6	with	with	IN
cord-023168-cd7adns8	77	7	typhoid	typhoid	NN
cord-023168-cd7adns8	77	8	fever	fever	NN
cord-023168-cd7adns8	77	9	,	,	,
cord-023168-cd7adns8	77	10	minimum	minimum	JJ
cord-023168-cd7adns8	77	11	neutrophil	neutrophil	NN
cord-023168-cd7adns8	77	12	count	count	NN
cord-023168-cd7adns8	77	13	seldom	seldom	RB
cord-023168-cd7adns8	77	14	falls	fall	VBZ
cord-023168-cd7adns8	77	15	below	below	IN
cord-023168-cd7adns8	77	16	0.6	0.6	CD
cord-023168-cd7adns8	77	17	×	×	CD
cord-023168-cd7adns8	77	18	10	10	CD
cord-023168-cd7adns8	77	19	9	9	CD
cord-023168-cd7adns8	77	20	/L	/L	.
cord-023168-cd7adns8	77	21	and	and	CC
cord-023168-cd7adns8	77	22	the	the	DT
cord-023168-cd7adns8	77	23	BOX	BOX	NNP
cord-023168-cd7adns8	77	24	neutropenia	neutropenia	NN
cord-023168-cd7adns8	77	25	may	may	MD
cord-023168-cd7adns8	77	26	not	not	RB
cord-023168-cd7adns8	77	27	develop	develop	VB
cord-023168-cd7adns8	77	28	until	until	IN
cord-023168-cd7adns8	77	29	after	after	IN
cord-023168-cd7adns8	77	30	the	the	DT
cord-023168-cd7adns8	77	31	first	first	JJ
cord-023168-cd7adns8	77	32	week	week	NN
cord-023168-cd7adns8	77	33	of	of	IN
cord-023168-cd7adns8	77	34	illness	illness	NN
cord-023168-cd7adns8	77	35	.	.	.
cord-023168-cd7adns8	78	1	Infectious	infectious	JJ
cord-023168-cd7adns8	78	2	hepatitis	hepatitis	NN
cord-023168-cd7adns8	78	3	and	and	CC
cord-023168-cd7adns8	78	4	yellow	yellow	JJ
cord-023168-cd7adns8	78	5	fever	fever	NN
cord-023168-cd7adns8	78	6	can	can	MD
cord-023168-cd7adns8	78	7	both	both	DT
cord-023168-cd7adns8	78	8	cause	cause	VB
cord-023168-cd7adns8	78	9	neutropenia	neutropenia	NN
cord-023168-cd7adns8	78	10	.	.	.
cord-023168-cd7adns8	79	1	Overwhelming	overwhelming	JJ
cord-023168-cd7adns8	79	2	infections	infection	NNS
cord-023168-cd7adns8	79	3	can	can	MD
cord-023168-cd7adns8	79	4	lead	lead	VB
cord-023168-cd7adns8	79	5	to	to	IN
cord-023168-cd7adns8	79	6	a	a	DT
cord-023168-cd7adns8	79	7	failure	failure	NN
cord-023168-cd7adns8	79	8	of	of	IN
cord-023168-cd7adns8	79	9	bone	bone	NN
cord-023168-cd7adns8	79	10	marrow	marrow	NN
cord-023168-cd7adns8	79	11	production	production	NN
cord-023168-cd7adns8	79	12	of	of	IN
cord-023168-cd7adns8	79	13	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	79	14	,	,	,
cord-023168-cd7adns8	79	15	especially	especially	RB
cord-023168-cd7adns8	79	16	in	in	IN
cord-023168-cd7adns8	79	17	undernourished	undernourished	JJ
cord-023168-cd7adns8	79	18	individuals	individual	NNS
cord-023168-cd7adns8	79	19	and	and	CC
cord-023168-cd7adns8	79	20	alcoholics	alcoholic	NNS
cord-023168-cd7adns8	79	21	.	.	.
cord-023168-cd7adns8	80	1	Individuals	individual	NNS
cord-023168-cd7adns8	80	2	with	with	IN
cord-023168-cd7adns8	80	3	severe	severe	JJ
cord-023168-cd7adns8	80	4	neutropenia	neutropenia	NN
cord-023168-cd7adns8	80	5	can	can	MD
cord-023168-cd7adns8	80	6	develop	develop	VB
cord-023168-cd7adns8	80	7	lifethreatening	lifethreatening	JJ
cord-023168-cd7adns8	80	8	septicaemia	septicaemia	NN
cord-023168-cd7adns8	80	9	,	,	,
cord-023168-cd7adns8	80	10	often	often	RB
cord-023168-cd7adns8	80	11	from	from	IN
cord-023168-cd7adns8	80	12	endogenous	endogenous	JJ
cord-023168-cd7adns8	80	13	flora	flora	NNS
cord-023168-cd7adns8	80	14	(	(	-LRB-
cord-023168-cd7adns8	80	15	e.g.	e.g.	DT
cord-023168-cd7adns8	80	16	oral	oral	JJ
cord-023168-cd7adns8	80	17	cavity	cavity	NN
cord-023168-cd7adns8	80	18	)	)	-RRB-
cord-023168-cd7adns8	80	19	,	,	,
cord-023168-cd7adns8	80	20	and	and	CC
cord-023168-cd7adns8	80	21	stringent	stringent	JJ
cord-023168-cd7adns8	80	22	measures	measure	NNS
cord-023168-cd7adns8	80	23	should	should	MD
cord-023168-cd7adns8	80	24	be	be	VB
cord-023168-cd7adns8	80	25	taken	take	VBN
cord-023168-cd7adns8	80	26	to	to	TO
cord-023168-cd7adns8	80	27	avoid	avoid	VB
cord-023168-cd7adns8	80	28	situations	situation	NNS
cord-023168-cd7adns8	80	29	which	which	WDT
cord-023168-cd7adns8	80	30	may	may	MD
cord-023168-cd7adns8	80	31	predispose	predispose	VB
cord-023168-cd7adns8	80	32	these	these	DT
cord-023168-cd7adns8	80	33	individuals	individual	NNS
cord-023168-cd7adns8	80	34	to	to	IN
cord-023168-cd7adns8	80	35	infections	infection	NNS
cord-023168-cd7adns8	80	36	.	.	.
cord-023168-cd7adns8	81	1	They	-PRON-	PRP
cord-023168-cd7adns8	81	2	may	may	MD
cord-023168-cd7adns8	81	3	need	need	VB
cord-023168-cd7adns8	81	4	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	81	5	antimicrobials	antimicrobial	NNS
cord-023168-cd7adns8	81	6	and	and	CC
cord-023168-cd7adns8	81	7	should	should	MD
cord-023168-cd7adns8	81	8	have	have	VB
cord-023168-cd7adns8	81	9	rapid	rapid	JJ
cord-023168-cd7adns8	81	10	access	access	NN
cord-023168-cd7adns8	81	11	to	to	IN
cord-023168-cd7adns8	81	12	medical	medical	JJ
cord-023168-cd7adns8	81	13	care	care	NN
cord-023168-cd7adns8	81	14	.	.	.
cord-023168-cd7adns8	82	1	Fungal	fungal	JJ
cord-023168-cd7adns8	82	2	infections	infection	NNS
cord-023168-cd7adns8	82	3	are	be	VBP
cord-023168-cd7adns8	82	4	less	less	RBR
cord-023168-cd7adns8	82	5	common	common	JJ
cord-023168-cd7adns8	82	6	than	than	IN
cord-023168-cd7adns8	82	7	bacterial	bacterial	JJ
cord-023168-cd7adns8	82	8	infections	infection	NNS
cord-023168-cd7adns8	82	9	in	in	IN
cord-023168-cd7adns8	82	10	neutropenic	neutropenic	JJ
cord-023168-cd7adns8	82	11	individuals	individual	NNS
cord-023168-cd7adns8	82	12	,	,	,
cord-023168-cd7adns8	82	13	and	and	CC
cord-023168-cd7adns8	82	14	viral	viral	JJ
cord-023168-cd7adns8	82	15	or	or	CC
cord-023168-cd7adns8	82	16	parasitic	parasitic	JJ
cord-023168-cd7adns8	82	17	infections	infection	NNS
cord-023168-cd7adns8	82	18	rarely	rarely	RB
cord-023168-cd7adns8	82	19	occur	occur	VBP
cord-023168-cd7adns8	82	20	with	with	IN
cord-023168-cd7adns8	82	21	isolated	isolated	JJ
cord-023168-cd7adns8	82	22	neutropenia	neutropenia	NN
cord-023168-cd7adns8	82	23	.	.	.
cord-023168-cd7adns8	83	1	Granulocyte	Granulocyte	NNP
cord-023168-cd7adns8	83	2	colony	colony	NN
cord-023168-cd7adns8	83	3	stimulating	stimulate	VBG
cord-023168-cd7adns8	83	4	factor	factor	NN
cord-023168-cd7adns8	84	1	(	(	-LRB-
cord-023168-cd7adns8	84	2	GCSF	GCSF	NNP
cord-023168-cd7adns8	84	3	)	)	-RRB-
cord-023168-cd7adns8	84	4	injections	injection	NNS
cord-023168-cd7adns8	84	5	can	can	MD
cord-023168-cd7adns8	84	6	be	be	VB
cord-023168-cd7adns8	84	7	helpful	helpful	JJ
cord-023168-cd7adns8	84	8	in	in	IN
cord-023168-cd7adns8	84	9	raising	raise	VBG
cord-023168-cd7adns8	84	10	the	the	DT
cord-023168-cd7adns8	84	11	neutrophil	neutrophil	NN
cord-023168-cd7adns8	84	12	count	count	NN
cord-023168-cd7adns8	84	13	in	in	IN
cord-023168-cd7adns8	84	14	patients	patient	NNS
cord-023168-cd7adns8	84	15	with	with	IN
cord-023168-cd7adns8	84	16	complicating	complicate	VBG
cord-023168-cd7adns8	84	17	infections	infection	NNS
cord-023168-cd7adns8	84	18	since	since	IN
cord-023168-cd7adns8	84	19	it	-PRON-	PRP
cord-023168-cd7adns8	84	20	stimulates	stimulate	VBZ
cord-023168-cd7adns8	84	21	the	the	DT
cord-023168-cd7adns8	84	22	release	release	NN
cord-023168-cd7adns8	84	23	of	of	IN
cord-023168-cd7adns8	84	24	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	84	25	from	from	IN
cord-023168-cd7adns8	84	26	the	the	DT
cord-023168-cd7adns8	84	27	marrow	marrow	NN
cord-023168-cd7adns8	84	28	,	,	,
cord-023168-cd7adns8	84	29	but	but	CC
cord-023168-cd7adns8	84	30	GCSF	GCSF	NNP
cord-023168-cd7adns8	84	31	is	be	VBZ
cord-023168-cd7adns8	84	32	only	only	RB
cord-023168-cd7adns8	84	33	useful	useful	JJ
cord-023168-cd7adns8	84	34	if	if	IN
cord-023168-cd7adns8	84	35	there	there	EX
cord-023168-cd7adns8	84	36	is	be	VBZ
cord-023168-cd7adns8	84	37	some	some	DT
cord-023168-cd7adns8	84	38	bone	bone	NN
cord-023168-cd7adns8	84	39	marrow	marrow	NN
cord-023168-cd7adns8	84	40	reserve	reserve	NN
cord-023168-cd7adns8	84	41	.	.	.
cord-023168-cd7adns8	85	1	Patients	patient	NNS
cord-023168-cd7adns8	85	2	with	with	IN
cord-023168-cd7adns8	85	3	some	some	DT
cord-023168-cd7adns8	85	4	congenital	congenital	JJ
cord-023168-cd7adns8	85	5	or	or	CC
cord-023168-cd7adns8	85	6	immune	immune	JJ
cord-023168-cd7adns8	85	7	forms	form	NNS
cord-023168-cd7adns8	85	8	of	of	IN
cord-023168-cd7adns8	85	9	neutropenia	neutropenia	NN
cord-023168-cd7adns8	85	10	can	can	MD
cord-023168-cd7adns8	85	11	tolerate	tolerate	VB
cord-023168-cd7adns8	85	12	persistently	persistently	RB
cord-023168-cd7adns8	85	13	low	low	JJ
cord-023168-cd7adns8	85	14	counts	count	NNS
cord-023168-cd7adns8	85	15	without	without	IN
cord-023168-cd7adns8	85	16	any	any	DT
cord-023168-cd7adns8	85	17	increase	increase	NN
cord-023168-cd7adns8	85	18	in	in	IN
cord-023168-cd7adns8	85	19	the	the	DT
cord-023168-cd7adns8	85	20	incidence	incidence	NN
cord-023168-cd7adns8	85	21	of	of	IN
cord-023168-cd7adns8	85	22	infections	infection	NNS
cord-023168-cd7adns8	85	23	.	.	.
cord-023168-cd7adns8	86	1	Monocytosis	Monocytosis	NNP
cord-023168-cd7adns8	86	2	occurs	occur	VBZ
cord-023168-cd7adns8	86	3	in	in	IN
cord-023168-cd7adns8	86	4	chronic	chronic	JJ
cord-023168-cd7adns8	86	5	infections	infection	NNS
cord-023168-cd7adns8	86	6	and	and	CC
cord-023168-cd7adns8	86	7	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	86	8	conditions	condition	NNS
cord-023168-cd7adns8	86	9	.	.	.
cord-023168-cd7adns8	87	1	Protozoan	protozoan	NN
cord-023168-cd7adns8	87	2	infections	infection	NNS
cord-023168-cd7adns8	87	3	such	such	JJ
cord-023168-cd7adns8	87	4	as	as	IN
cord-023168-cd7adns8	87	5	typhus	typhus	NN
cord-023168-cd7adns8	87	6	,	,	,
cord-023168-cd7adns8	87	7	trypanosomiasis	trypanosomiasis	NN
cord-023168-cd7adns8	87	8	and	and	CC
cord-023168-cd7adns8	87	9	kala	kala	NNP
cord-023168-cd7adns8	87	10	-	-	HYPH
cord-023168-cd7adns8	87	11	azar	azar	NNP
cord-023168-cd7adns8	87	12	may	may	MD
cord-023168-cd7adns8	87	13	be	be	VB
cord-023168-cd7adns8	87	14	associated	associate	VBN
cord-023168-cd7adns8	87	15	with	with	IN
cord-023168-cd7adns8	87	16	monocytosis	monocytosis	NNP
cord-023168-cd7adns8	87	17	.	.	.
cord-023168-cd7adns8	88	1	Chronic	chronic	JJ
cord-023168-cd7adns8	88	2	and	and	CC
cord-023168-cd7adns8	88	3	juvenile	juvenile	JJ
cord-023168-cd7adns8	88	4	myelomonocytic	myelomonocytic	NN
cord-023168-cd7adns8	88	5	leukaemias	leukaemias	NNP
cord-023168-cd7adns8	88	6	are	be	VBP
cord-023168-cd7adns8	88	7	malignant	malignant	JJ
cord-023168-cd7adns8	88	8	disorders	disorder	NNS
cord-023168-cd7adns8	88	9	in	in	IN
cord-023168-cd7adns8	88	10	which	which	WDT
cord-023168-cd7adns8	88	11	monocytosis	monocytosis	NNP
cord-023168-cd7adns8	88	12	may	may	MD
cord-023168-cd7adns8	88	13	be	be	VB
cord-023168-cd7adns8	88	14	severe	severe	JJ
cord-023168-cd7adns8	88	15	;	;	:
cord-023168-cd7adns8	88	16	acute	acute	JJ
cord-023168-cd7adns8	88	17	monocytic	monocytic	JJ
cord-023168-cd7adns8	88	18	leukaemias	leukaemias	NNP
cord-023168-cd7adns8	88	19	may	may	MD
cord-023168-cd7adns8	88	20	present	present	VB
cord-023168-cd7adns8	88	21	with	with	IN
cord-023168-cd7adns8	88	22	mild	mild	JJ
cord-023168-cd7adns8	88	23	to	to	IN
cord-023168-cd7adns8	88	24	moderate	moderate	JJ
cord-023168-cd7adns8	88	25	monocytosis	monocytosis	NN
cord-023168-cd7adns8	88	26	.	.	.
cord-023168-cd7adns8	89	1	Monocytosis	Monocytosis	NNP
cord-023168-cd7adns8	89	2	,	,	,
cord-023168-cd7adns8	89	3	and	and	CC
cord-023168-cd7adns8	89	4	particularly	particularly	RB
cord-023168-cd7adns8	89	5	a	a	DT
cord-023168-cd7adns8	89	6	monocyte	monocyte	NNP
cord-023168-cd7adns8	89	7	:	:	:
cord-023168-cd7adns8	89	8	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	89	9	ratio	ratio	NN
cord-023168-cd7adns8	89	10	greater	great	JJR
cord-023168-cd7adns8	89	11	than	than	IN
cord-023168-cd7adns8	89	12	0.8	0.8	CD
cord-023168-cd7adns8	89	13	-	-	SYM
cord-023168-cd7adns8	89	14	1.0	1.0	CD
cord-023168-cd7adns8	89	15	,	,	,
cord-023168-cd7adns8	89	16	may	may	MD
cord-023168-cd7adns8	89	17	indicate	indicate	VB
cord-023168-cd7adns8	89	18	active	active	JJ
cord-023168-cd7adns8	89	19	progression	progression	NN
cord-023168-cd7adns8	89	20	of	of	IN
cord-023168-cd7adns8	89	21	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	89	22	and	and	CC
cord-023168-cd7adns8	89	23	an	an	DT
cord-023168-cd7adns8	89	24	unfavourable	unfavourable	JJ
cord-023168-cd7adns8	89	25	prognosis	prognosis	NN
cord-023168-cd7adns8	89	26	.	.	.
cord-023168-cd7adns8	90	1	The	the	DT
cord-023168-cd7adns8	90	2	normal	normal	JJ
cord-023168-cd7adns8	90	3	ratio	ratio	NN
cord-023168-cd7adns8	90	4	of	of	IN
cord-023168-cd7adns8	90	5	0.3	0.3	CD
cord-023168-cd7adns8	90	6	or	or	CC
cord-023168-cd7adns8	90	7	less	less	JJR
cord-023168-cd7adns8	90	8	is	be	VBZ
cord-023168-cd7adns8	90	9	restored	restore	VBN
cord-023168-cd7adns8	90	10	when	when	WRB
cord-023168-cd7adns8	90	11	the	the	DT
cord-023168-cd7adns8	90	12	healing	healing	NN
cord-023168-cd7adns8	90	13	process	process	NN
cord-023168-cd7adns8	90	14	is	be	VBZ
cord-023168-cd7adns8	90	15	complete	complete	JJ
cord-023168-cd7adns8	90	16	.	.	.
cord-023168-cd7adns8	91	1	A	a	DT
cord-023168-cd7adns8	91	2	decreased	decrease	VBN
cord-023168-cd7adns8	91	3	absolute	absolute	JJ
cord-023168-cd7adns8	91	4	monocyte	monocyte	NNP
cord-023168-cd7adns8	91	5	count	count	NN
cord-023168-cd7adns8	91	6	occurs	occur	VBZ
cord-023168-cd7adns8	91	7	in	in	IN
cord-023168-cd7adns8	91	8	bone	bone	NN
cord-023168-cd7adns8	91	9	marrow	marrow	NN
cord-023168-cd7adns8	91	10	failure	failure	NN
cord-023168-cd7adns8	91	11	states	state	NNS
cord-023168-cd7adns8	91	12	such	such	JJ
cord-023168-cd7adns8	91	13	as	as	IN
cord-023168-cd7adns8	91	14	aplastic	aplastic	JJ
cord-023168-cd7adns8	91	15	anaemia	anaemia	NN
cord-023168-cd7adns8	91	16	or	or	CC
cord-023168-cd7adns8	91	17	after	after	IN
cord-023168-cd7adns8	91	18	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	91	19	.	.	.
cord-023168-cd7adns8	92	1	Low	low	JJ
cord-023168-cd7adns8	92	2	monocyte	monocyte	NNP
cord-023168-cd7adns8	92	3	counts	count	NNS
cord-023168-cd7adns8	92	4	can	can	MD
cord-023168-cd7adns8	92	5	occur	occur	VB
cord-023168-cd7adns8	92	6	with	with	IN
cord-023168-cd7adns8	92	7	overwhelming	overwhelming	JJ
cord-023168-cd7adns8	92	8	sepsis	sepsis	NN
cord-023168-cd7adns8	92	9	and	and	CC
cord-023168-cd7adns8	92	10	with	with	IN
cord-023168-cd7adns8	92	11	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	92	12	.	.	.
cord-023168-cd7adns8	93	1	Monocytopenia	Monocytopenia	NNP
cord-023168-cd7adns8	93	2	is	be	VBZ
cord-023168-cd7adns8	93	3	a	a	DT
cord-023168-cd7adns8	93	4	characteristic	characteristic	JJ
cord-023168-cd7adns8	93	5	feature	feature	NN
cord-023168-cd7adns8	93	6	of	of	IN
cord-023168-cd7adns8	93	7	hairy	hairy	JJ
cord-023168-cd7adns8	93	8	cell	cell	NN
cord-023168-cd7adns8	93	9	leukaemia	leukaemia	NN
cord-023168-cd7adns8	93	10	and	and	CC
cord-023168-cd7adns8	93	11	is	be	VBZ
cord-023168-cd7adns8	93	12	considered	consider	VBN
cord-023168-cd7adns8	93	13	to	to	TO
cord-023168-cd7adns8	93	14	be	be	VB
cord-023168-cd7adns8	93	15	a	a	DT
cord-023168-cd7adns8	93	16	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	93	17	hallmark	hallmark	NN
cord-023168-cd7adns8	93	18	of	of	IN
cord-023168-cd7adns8	93	19	this	this	DT
cord-023168-cd7adns8	93	20	disease	disease	NN
cord-023168-cd7adns8	93	21	.	.	.
cord-023168-cd7adns8	94	1	Peripheral	peripheral	JJ
cord-023168-cd7adns8	94	2	blood	blood	NN
cord-023168-cd7adns8	94	3	contains	contain	VBZ
cord-023168-cd7adns8	94	4	only	only	RB
cord-023168-cd7adns8	94	5	around	around	RB
cord-023168-cd7adns8	94	6	2	2	CD
cord-023168-cd7adns8	94	7	%	%	NN
cord-023168-cd7adns8	94	8	of	of	IN
cord-023168-cd7adns8	94	9	the	the	DT
cord-023168-cd7adns8	94	10	total	total	JJ
cord-023168-cd7adns8	94	11	body	body	NN
cord-023168-cd7adns8	94	12	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	94	13	population	population	NN
cord-023168-cd7adns8	94	14	since	since	IN
cord-023168-cd7adns8	94	15	these	these	DT
cord-023168-cd7adns8	94	16	represent	represent	VBP
cord-023168-cd7adns8	94	17	the	the	DT
cord-023168-cd7adns8	94	18	cells	cell	NNS
cord-023168-cd7adns8	94	19	present	present	JJ
cord-023168-cd7adns8	94	20	in	in	IN
cord-023168-cd7adns8	94	21	the	the	DT
cord-023168-cd7adns8	94	22	blood	blood	NN
cord-023168-cd7adns8	94	23	during	during	IN
cord-023168-cd7adns8	94	24	their	-PRON-	PRP$
cord-023168-cd7adns8	94	25	transit	transit	NN
cord-023168-cd7adns8	94	26	into	into	IN
cord-023168-cd7adns8	94	27	secondary	secondary	JJ
cord-023168-cd7adns8	94	28	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	94	29	organs	organ	NNS
cord-023168-cd7adns8	94	30	.	.	.
cord-023168-cd7adns8	95	1	Wide	wide	JJ
cord-023168-cd7adns8	95	2	variations	variation	NNS
cord-023168-cd7adns8	95	3	exist	exist	VBP
cord-023168-cd7adns8	95	4	in	in	IN
cord-023168-cd7adns8	95	5	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	95	6	counts	count	NNS
cord-023168-cd7adns8	95	7	between	between	IN
cord-023168-cd7adns8	95	8	individuals	individual	NNS
cord-023168-cd7adns8	95	9	especially	especially	RB
cord-023168-cd7adns8	95	10	in	in	IN
cord-023168-cd7adns8	95	11	childhood	childhood	NN
cord-023168-cd7adns8	95	12	.	.	.
cord-023168-cd7adns8	96	1	Lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	96	2	counts	count	NNS
cord-023168-cd7adns8	96	3	exhibit	exhibit	VBP
cord-023168-cd7adns8	96	4	a	a	DT
cord-023168-cd7adns8	96	5	diurnal	diurnal	JJ
cord-023168-cd7adns8	96	6	pattern	pattern	NN
cord-023168-cd7adns8	96	7	;	;	:
cord-023168-cd7adns8	96	8	peaking	peak	VBG
cord-023168-cd7adns8	96	9	at	at	IN
cord-023168-cd7adns8	96	10	night	night	NN
cord-023168-cd7adns8	96	11	with	with	IN
cord-023168-cd7adns8	96	12	a	a	DT
cord-023168-cd7adns8	96	13	nadir	nadir	NN
cord-023168-cd7adns8	96	14	in	in	IN
cord-023168-cd7adns8	96	15	the	the	DT
cord-023168-cd7adns8	96	16	morning	morning	NN
cord-023168-cd7adns8	96	17	.	.	.
cord-023168-cd7adns8	97	1	Lymphocytosis	Lymphocytosis	NNP
cord-023168-cd7adns8	97	2	is	be	VBZ
cord-023168-cd7adns8	97	3	characteristic	characteristic	JJ
cord-023168-cd7adns8	97	4	of	of	IN
cord-023168-cd7adns8	97	5	infectious	infectious	JJ
cord-023168-cd7adns8	97	6	mononucleosis	mononucleosis	NN
cord-023168-cd7adns8	97	7	and	and	CC
cord-023168-cd7adns8	97	8	many	many	JJ
cord-023168-cd7adns8	97	9	atypical	atypical	JJ
cord-023168-cd7adns8	97	10	and	and	CC
cord-023168-cd7adns8	97	11	large	large	JJ
cord-023168-cd7adns8	97	12	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	97	13	can	can	MD
cord-023168-cd7adns8	97	14	be	be	VB
cord-023168-cd7adns8	97	15	seen	see	VBN
cord-023168-cd7adns8	97	16	in	in	IN
cord-023168-cd7adns8	97	17	the	the	DT
cord-023168-cd7adns8	97	18	peripheral	peripheral	JJ
cord-023168-cd7adns8	97	19	blood	blood	NN
cord-023168-cd7adns8	97	20	film	film	NN
cord-023168-cd7adns8	97	21	.	.	.
cord-023168-cd7adns8	98	1	These	these	DT
cord-023168-cd7adns8	98	2	atypical	atypical	JJ
cord-023168-cd7adns8	98	3	cells	cell	NNS
cord-023168-cd7adns8	98	4	can	can	MD
cord-023168-cd7adns8	98	5	also	also	RB
cord-023168-cd7adns8	98	6	occur	occur	VB
cord-023168-cd7adns8	98	7	in	in	IN
cord-023168-cd7adns8	98	8	cytomegalovirus	cytomegalovirus	JJ
cord-023168-cd7adns8	98	9	infection	infection	NN
cord-023168-cd7adns8	98	10	and	and	CC
cord-023168-cd7adns8	98	11	infectious	infectious	JJ
cord-023168-cd7adns8	98	12	hepatitis	hepatitis	NN
cord-023168-cd7adns8	98	13	.	.	.
cord-023168-cd7adns8	99	1	Absolute	absolute	JJ
cord-023168-cd7adns8	99	2	lymphocytosis	lymphocytosis	NN
cord-023168-cd7adns8	99	3	can	can	MD
cord-023168-cd7adns8	99	4	occur	occur	VB
cord-023168-cd7adns8	99	5	with	with	IN
cord-023168-cd7adns8	99	6	chronic	chronic	JJ
cord-023168-cd7adns8	99	7	infections	infection	NNS
cord-023168-cd7adns8	99	8	such	such	JJ
cord-023168-cd7adns8	99	9	as	as	IN
cord-023168-cd7adns8	99	10	brucellosis	brucellosis	NN
cord-023168-cd7adns8	99	11	and	and	CC
cord-023168-cd7adns8	99	12	in	in	IN
cord-023168-cd7adns8	99	13	the	the	DT
cord-023168-cd7adns8	99	14	recovery	recovery	NN
cord-023168-cd7adns8	99	15	stages	stage	NNS
cord-023168-cd7adns8	99	16	of	of	IN
cord-023168-cd7adns8	99	17	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	99	18	.	.	.
cord-023168-cd7adns8	100	1	Lymphocytosis	Lymphocytosis	NNP
cord-023168-cd7adns8	100	2	is	be	VBZ
cord-023168-cd7adns8	100	3	unusual	unusual	JJ
cord-023168-cd7adns8	100	4	in	in	IN
cord-023168-cd7adns8	100	5	bacterial	bacterial	JJ
cord-023168-cd7adns8	100	6	infections	infection	NNS
cord-023168-cd7adns8	100	7	except	except	IN
cord-023168-cd7adns8	100	8	in	in	IN
cord-023168-cd7adns8	100	9	the	the	DT
cord-023168-cd7adns8	100	10	case	case	NN
cord-023168-cd7adns8	100	11	of	of	IN
cord-023168-cd7adns8	100	12	pertussis	pertussis	NN
cord-023168-cd7adns8	100	13	.	.	.
cord-023168-cd7adns8	101	1	Heavy	heavy	JJ
cord-023168-cd7adns8	101	2	smoking	smoking	NN
cord-023168-cd7adns8	101	3	is	be	VBZ
cord-023168-cd7adns8	101	4	also	also	RB
cord-023168-cd7adns8	101	5	an	an	DT
cord-023168-cd7adns8	101	6	often	often	RB
cord-023168-cd7adns8	101	7	overlooked	overlook	VBN
cord-023168-cd7adns8	101	8	cause	cause	NN
cord-023168-cd7adns8	101	9	of	of	IN
cord-023168-cd7adns8	101	10	lymphocytosis	lymphocytosis	NN
cord-023168-cd7adns8	101	11	and	and	CC
cord-023168-cd7adns8	101	12	is	be	VBZ
cord-023168-cd7adns8	101	13	probably	probably	RB
cord-023168-cd7adns8	101	14	one	one	CD
cord-023168-cd7adns8	101	15	of	of	IN
cord-023168-cd7adns8	101	16	the	the	DT
cord-023168-cd7adns8	101	17	commonest	common	JJS
cord-023168-cd7adns8	101	18	reasons	reason	NNS
cord-023168-cd7adns8	101	19	for	for	IN
cord-023168-cd7adns8	101	20	a	a	DT
cord-023168-cd7adns8	101	21	mild	mild	JJ
cord-023168-cd7adns8	101	22	to	to	TO
cord-023168-cd7adns8	101	23	moderate	moderate	JJ
cord-023168-cd7adns8	101	24	increase	increase	NN
cord-023168-cd7adns8	101	25	in	in	IN
cord-023168-cd7adns8	101	26	the	the	DT
cord-023168-cd7adns8	101	27	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	101	28	count	count	NN
cord-023168-cd7adns8	101	29	.	.	.
cord-023168-cd7adns8	102	1	Malignant	malignant	JJ
cord-023168-cd7adns8	102	2	bone	bone	NN
cord-023168-cd7adns8	102	3	marrow	marrow	NN
cord-023168-cd7adns8	102	4	disorders	disorder	NNS
cord-023168-cd7adns8	102	5	,	,	,
cord-023168-cd7adns8	102	6	predominantly	predominantly	RB
cord-023168-cd7adns8	102	7	acute	acute	JJ
cord-023168-cd7adns8	102	8	lymphoblastic	lymphoblastic	JJ
cord-023168-cd7adns8	102	9	and	and	CC
cord-023168-cd7adns8	102	10	chronic	chronic	JJ
cord-023168-cd7adns8	102	11	lymphocytic	lymphocytic	JJ
cord-023168-cd7adns8	102	12	leukaemia	leukaemia	NN
cord-023168-cd7adns8	102	13	and	and	CC
cord-023168-cd7adns8	102	14	non	non	JJ
cord-023168-cd7adns8	102	15	-	-	NNP
cord-023168-cd7adns8	102	16	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	102	17	's	's	POS
cord-023168-cd7adns8	102	18	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	102	19	,	,	,
cord-023168-cd7adns8	102	20	can	can	MD
cord-023168-cd7adns8	102	21	cause	cause	VB
cord-023168-cd7adns8	102	22	lymphocytosis	lymphocytosis	NNP
cord-023168-cd7adns8	102	23	.	.	.
cord-023168-cd7adns8	103	1	These	these	DT
cord-023168-cd7adns8	103	2	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	103	3	may	may	MD
cord-023168-cd7adns8	103	4	have	have	VB
cord-023168-cd7adns8	103	5	characteristic	characteristic	JJ
cord-023168-cd7adns8	103	6	morphological	morphological	JJ
cord-023168-cd7adns8	103	7	changes	change	NNS
cord-023168-cd7adns8	103	8	identifiable	identifiable	JJ
cord-023168-cd7adns8	103	9	in	in	IN
cord-023168-cd7adns8	103	10	the	the	DT
cord-023168-cd7adns8	103	11	blood	blood	NN
cord-023168-cd7adns8	103	12	film	film	NN
cord-023168-cd7adns8	103	13	(	(	-LRB-
cord-023168-cd7adns8	103	14	e.g.	e.g.	IN
cord-023168-cd7adns8	103	15	smear	smear	NN
cord-023168-cd7adns8	103	16	cells	cell	NNS
cord-023168-cd7adns8	103	17	with	with	IN
cord-023168-cd7adns8	103	18	chronic	chronic	JJ
cord-023168-cd7adns8	103	19	lymphocytic	lymphocytic	JJ
cord-023168-cd7adns8	103	20	leukaemia	leukaemia	NN
cord-023168-cd7adns8	103	21	)	)	-RRB-
cord-023168-cd7adns8	103	22	and	and	CC
cord-023168-cd7adns8	103	23	the	the	DT
cord-023168-cd7adns8	103	24	correct	correct	JJ
cord-023168-cd7adns8	103	25	diagnosis	diagnosis	NN
cord-023168-cd7adns8	103	26	can	can	MD
cord-023168-cd7adns8	103	27	be	be	VB
cord-023168-cd7adns8	103	28	confirmed	confirm	VBN
cord-023168-cd7adns8	103	29	by	by	IN
cord-023168-cd7adns8	103	30	immunophenotyping	immunophenotype	VBG
cord-023168-cd7adns8	103	31	for	for	IN
cord-023168-cd7adns8	103	32	specific	specific	JJ
cord-023168-cd7adns8	103	33	combinations	combination	NNS
cord-023168-cd7adns8	103	34	of	of	IN
cord-023168-cd7adns8	103	35	cell	cell	NN
cord-023168-cd7adns8	103	36	markers	marker	NNS
cord-023168-cd7adns8	103	37	.	.	.
cord-023168-cd7adns8	104	1	Lymphopenia	Lymphopenia	NNP
cord-023168-cd7adns8	104	2	is	be	VBZ
cord-023168-cd7adns8	104	3	due	due	JJ
cord-023168-cd7adns8	104	4	to	to	IN
cord-023168-cd7adns8	104	5	decreased	decrease	VBN
cord-023168-cd7adns8	104	6	production	production	NN
cord-023168-cd7adns8	104	7	,	,	,
cord-023168-cd7adns8	104	8	redistribution	redistribution	NN
cord-023168-cd7adns8	104	9	or	or	CC
cord-023168-cd7adns8	104	10	increased	increase	VBN
cord-023168-cd7adns8	104	11	rate	rate	NN
cord-023168-cd7adns8	104	12	of	of	IN
cord-023168-cd7adns8	104	13	death	death	NN
cord-023168-cd7adns8	104	14	of	of	IN
cord-023168-cd7adns8	104	15	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	104	16	.	.	.
cord-023168-cd7adns8	105	1	Decreased	decrease	VBN
cord-023168-cd7adns8	105	2	production	production	NN
cord-023168-cd7adns8	105	3	usually	usually	RB
cord-023168-cd7adns8	105	4	results	result	VBZ
cord-023168-cd7adns8	105	5	from	from	IN
cord-023168-cd7adns8	105	6	cytotoxic	cytotoxic	JJ
cord-023168-cd7adns8	105	7	drugs	drug	NNS
cord-023168-cd7adns8	105	8	and	and	CC
cord-023168-cd7adns8	105	9	radiotherapy	radiotherapy	NN
cord-023168-cd7adns8	105	10	,	,	,
cord-023168-cd7adns8	105	11	while	while	IN
cord-023168-cd7adns8	105	12	increased	increase	VBN
cord-023168-cd7adns8	105	13	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	105	14	death	death	NN
cord-023168-cd7adns8	105	15	can	can	MD
cord-023168-cd7adns8	105	16	occur	occur	VB
cord-023168-cd7adns8	105	17	in	in	IN
cord-023168-cd7adns8	105	18	infections	infection	NNS
cord-023168-cd7adns8	105	19	such	such	JJ
cord-023168-cd7adns8	105	20	as	as	IN
cord-023168-cd7adns8	105	21	influenza	influenza	NN
cord-023168-cd7adns8	105	22	and	and	CC
cord-023168-cd7adns8	105	23	HIV	HIV	NNP
cord-023168-cd7adns8	105	24	.	.	.
cord-023168-cd7adns8	106	1	Occasionally	occasionally	RB
cord-023168-cd7adns8	106	2	,	,	,
cord-023168-cd7adns8	106	3	an	an	DT
cord-023168-cd7adns8	106	4	isolated	isolated	JJ
cord-023168-cd7adns8	106	5	low	low	JJ
cord-023168-cd7adns8	106	6	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	106	7	count	count	NN
cord-023168-cd7adns8	106	8	in	in	IN
cord-023168-cd7adns8	106	9	the	the	DT
cord-023168-cd7adns8	106	10	context	context	NN
cord-023168-cd7adns8	106	11	of	of	IN
cord-023168-cd7adns8	106	12	an	an	DT
cord-023168-cd7adns8	106	13	otherwise	otherwise	RB
cord-023168-cd7adns8	106	14	normal	normal	JJ
cord-023168-cd7adns8	106	15	full	full	JJ
cord-023168-cd7adns8	106	16	blood	blood	NN
cord-023168-cd7adns8	106	17	count	count	NN
cord-023168-cd7adns8	106	18	can	can	MD
cord-023168-cd7adns8	106	19	be	be	VB
cord-023168-cd7adns8	106	20	a	a	DT
cord-023168-cd7adns8	106	21	clue	clue	NN
cord-023168-cd7adns8	106	22	to	to	IN
cord-023168-cd7adns8	106	23	the	the	DT
cord-023168-cd7adns8	106	24	diagnosis	diagnosis	NN
cord-023168-cd7adns8	106	25	of	of	IN
cord-023168-cd7adns8	106	26	HIV	HIV	NNP
cord-023168-cd7adns8	106	27	.	.	.
cord-023168-cd7adns8	107	1	This	this	DT
cord-023168-cd7adns8	107	2	reflects	reflect	VBZ
cord-023168-cd7adns8	107	3	the	the	DT
cord-023168-cd7adns8	107	4	destruction	destruction	NN
cord-023168-cd7adns8	107	5	of	of	IN
cord-023168-cd7adns8	107	6	CD4	CD4	NNP
cord-023168-cd7adns8	107	7	+	+	CC
cord-023168-cd7adns8	107	8	T	t	NN
cord-023168-cd7adns8	107	9	cells	cell	NNS
cord-023168-cd7adns8	107	10	by	by	IN
cord-023168-cd7adns8	107	11	the	the	DT
cord-023168-cd7adns8	107	12	virus	virus	NN
cord-023168-cd7adns8	107	13	although	although	IN
cord-023168-cd7adns8	107	14	an	an	DT
cord-023168-cd7adns8	107	15	expansion	expansion	NN
cord-023168-cd7adns8	107	16	of	of	IN
cord-023168-cd7adns8	107	17	CD8	CD8	NNP
cord-023168-cd7adns8	107	18	+	+	CC
cord-023168-cd7adns8	107	19	T	T	NNP
cord-023168-cd7adns8	107	20	cells	cell	NNS
cord-023168-cd7adns8	107	21	may	may	MD
cord-023168-cd7adns8	107	22	raise	raise	VB
cord-023168-cd7adns8	107	23	the	the	DT
cord-023168-cd7adns8	107	24	total	total	JJ
cord-023168-cd7adns8	107	25	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	107	26	count	count	NN
cord-023168-cd7adns8	107	27	to	to	IN
cord-023168-cd7adns8	107	28	normal	normal	JJ
cord-023168-cd7adns8	107	29	levels	level	NNS
cord-023168-cd7adns8	107	30	.	.	.
cord-023168-cd7adns8	108	1	Redistribution	redistribution	NN
cord-023168-cd7adns8	108	2	rather	rather	RB
cord-023168-cd7adns8	108	3	than	than	IN
cord-023168-cd7adns8	108	4	depletion	depletion	NN
cord-023168-cd7adns8	108	5	of	of	IN
cord-023168-cd7adns8	108	6	total	total	JJ
cord-023168-cd7adns8	108	7	body	body	NN
cord-023168-cd7adns8	108	8	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	108	9	numbers	number	NNS
cord-023168-cd7adns8	108	10	occurs	occur	VBZ
cord-023168-cd7adns8	108	11	with	with	IN
cord-023168-cd7adns8	108	12	steroid	steroid	NN
cord-023168-cd7adns8	108	13	treatment	treatment	NN
cord-023168-cd7adns8	108	14	or	or	CC
cord-023168-cd7adns8	108	15	with	with	IN
cord-023168-cd7adns8	108	16	endogenous	endogenous	JJ
cord-023168-cd7adns8	108	17	secretion	secretion	NN
cord-023168-cd7adns8	108	18	of	of	IN
cord-023168-cd7adns8	108	19	corticosteroids	corticosteroid	NNS
cord-023168-cd7adns8	108	20	during	during	IN
cord-023168-cd7adns8	108	21	acute	acute	JJ
cord-023168-cd7adns8	108	22	illnesses	illness	NNS
cord-023168-cd7adns8	108	23	due	due	JJ
cord-023168-cd7adns8	108	24	to	to	IN
cord-023168-cd7adns8	108	25	the	the	DT
cord-023168-cd7adns8	108	26	retention	retention	NN
cord-023168-cd7adns8	108	27	of	of	IN
cord-023168-cd7adns8	108	28	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	108	29	in	in	IN
cord-023168-cd7adns8	108	30	secondary	secondary	JJ
cord-023168-cd7adns8	108	31	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	108	32	organs	organ	NNS
cord-023168-cd7adns8	108	33	.	.	.
cord-023168-cd7adns8	109	1	EOSINOPHILIA	EOSINOPHILIA	NNP
cord-023168-cd7adns8	109	2	Eosinophils	Eosinophils	NNP
cord-023168-cd7adns8	109	3	are	be	VBP
cord-023168-cd7adns8	109	4	involved	involve	VBN
cord-023168-cd7adns8	109	5	in	in	IN
cord-023168-cd7adns8	109	6	innate	innate	JJ
cord-023168-cd7adns8	109	7	immunity	immunity	NN
cord-023168-cd7adns8	109	8	and	and	CC
cord-023168-cd7adns8	109	9	hypersensitivity	hypersensitivity	NN
cord-023168-cd7adns8	109	10	.	.	.
cord-023168-cd7adns8	110	1	Their	-PRON-	PRP$
cord-023168-cd7adns8	110	2	number	number	NN
cord-023168-cd7adns8	110	3	in	in	IN
cord-023168-cd7adns8	110	4	the	the	DT
cord-023168-cd7adns8	110	5	circulation	circulation	NN
cord-023168-cd7adns8	110	6	is	be	VBZ
cord-023168-cd7adns8	110	7	relatively	relatively	RB
cord-023168-cd7adns8	110	8	small	small	JJ
cord-023168-cd7adns8	110	9	compared	compare	VBN
cord-023168-cd7adns8	110	10	to	to	IN
cord-023168-cd7adns8	110	11	other	other	JJ
cord-023168-cd7adns8	110	12	leukocytes	leukocyte	NNS
cord-023168-cd7adns8	110	13	because	because	IN
cord-023168-cd7adns8	110	14	they	-PRON-	PRP
cord-023168-cd7adns8	110	15	predominantly	predominantly	RB
cord-023168-cd7adns8	110	16	reside	reside	VBP
cord-023168-cd7adns8	110	17	in	in	IN
cord-023168-cd7adns8	110	18	tissues	tissue	NNS
cord-023168-cd7adns8	110	19	such	such	JJ
cord-023168-cd7adns8	110	20	as	as	IN
cord-023168-cd7adns8	110	21	the	the	DT
cord-023168-cd7adns8	110	22	gut	gut	NN
cord-023168-cd7adns8	110	23	,	,	,
cord-023168-cd7adns8	110	24	skin	skin	NN
cord-023168-cd7adns8	110	25	and	and	CC
cord-023168-cd7adns8	110	26	lungs	lung	NNS
cord-023168-cd7adns8	110	27	which	which	WDT
cord-023168-cd7adns8	110	28	are	be	VBP
cord-023168-cd7adns8	110	29	entry	entry	NN
cord-023168-cd7adns8	110	30	points	point	NNS
cord-023168-cd7adns8	110	31	for	for	IN
cord-023168-cd7adns8	110	32	allergens	allergen	NNS
cord-023168-cd7adns8	110	33	and	and	CC
cord-023168-cd7adns8	110	34	infections	infection	NNS
cord-023168-cd7adns8	110	35	.	.	.
cord-023168-cd7adns8	111	1	The	the	DT
cord-023168-cd7adns8	111	2	commonest	common	JJS
cord-023168-cd7adns8	111	3	causes	cause	NNS
cord-023168-cd7adns8	111	4	of	of	IN
cord-023168-cd7adns8	111	5	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	111	6	are	be	VBP
cord-023168-cd7adns8	111	7	helminthic	helminthic	JJ
cord-023168-cd7adns8	111	8	infections	infection	NNS
cord-023168-cd7adns8	111	9	,	,	,
cord-023168-cd7adns8	111	10	atopy	atopy	NN
cord-023168-cd7adns8	111	11	and	and	CC
cord-023168-cd7adns8	111	12	allergic	allergic	JJ
cord-023168-cd7adns8	111	13	diseases	disease	NNS
cord-023168-cd7adns8	111	14	,	,	,
cord-023168-cd7adns8	111	15	and	and	CC
cord-023168-cd7adns8	111	16	adverse	adverse	JJ
cord-023168-cd7adns8	111	17	drug	drug	NN
cord-023168-cd7adns8	111	18	reactions	reaction	NNS
cord-023168-cd7adns8	111	19	.	.	.
cord-023168-cd7adns8	112	1	Less	less	RBR
cord-023168-cd7adns8	112	2	common	common	JJ
cord-023168-cd7adns8	112	3	causes	cause	NNS
cord-023168-cd7adns8	112	4	are	be	VBP
cord-023168-cd7adns8	112	5	classified	classify	VBN
cord-023168-cd7adns8	112	6	under	under	IN
cord-023168-cd7adns8	112	7	the	the	DT
cord-023168-cd7adns8	112	8	umbrella	umbrella	NN
cord-023168-cd7adns8	112	9	term	term	NN
cord-023168-cd7adns8	112	10	of	of	IN
cord-023168-cd7adns8	112	11	hypereosinophilic	hypereosinophilic	NN
cord-023168-cd7adns8	112	12	syndromes	syndrome	NNS
cord-023168-cd7adns8	112	13	(	(	-LRB-
cord-023168-cd7adns8	112	14	Table	table	NN
cord-023168-cd7adns8	112	15	65	65	CD
cord-023168-cd7adns8	112	16	.1	.1	CD
cord-023168-cd7adns8	112	17	)	)	-RRB-
cord-023168-cd7adns8	112	18	.	.	.
cord-023168-cd7adns8	113	1	Since	since	IN
cord-023168-cd7adns8	113	2	parasitic	parasitic	JJ
cord-023168-cd7adns8	113	3	infections	infection	NNS
cord-023168-cd7adns8	113	4	are	be	VBP
cord-023168-cd7adns8	113	5	likely	likely	JJ
cord-023168-cd7adns8	113	6	to	to	TO
cord-023168-cd7adns8	113	7	be	be	VB
cord-023168-cd7adns8	113	8	the	the	DT
cord-023168-cd7adns8	113	9	commonest	common	JJS
cord-023168-cd7adns8	113	10	cause	cause	NN
cord-023168-cd7adns8	113	11	of	of	IN
cord-023168-cd7adns8	113	12	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	113	13	in	in	IN
cord-023168-cd7adns8	113	14	the	the	DT
cord-023168-cd7adns8	113	15	tropics	tropic	NNS
cord-023168-cd7adns8	113	16	and	and	CC
cord-023168-cd7adns8	113	17	in	in	IN
cord-023168-cd7adns8	113	18	returning	return	VBG
cord-023168-cd7adns8	113	19	travellers	traveller	NNS
cord-023168-cd7adns8	113	20	,	,	,
cord-023168-cd7adns8	113	21	an	an	DT
cord-023168-cd7adns8	113	22	extensive	extensive	JJ
cord-023168-cd7adns8	113	23	search	search	NN
cord-023168-cd7adns8	113	24	for	for	IN
cord-023168-cd7adns8	113	25	such	such	JJ
cord-023168-cd7adns8	113	26	infections	infection	NNS
cord-023168-cd7adns8	113	27	should	should	MD
cord-023168-cd7adns8	113	28	be	be	VB
cord-023168-cd7adns8	113	29	undertaken	undertake	VBN
cord-023168-cd7adns8	113	30	in	in	IN
cord-023168-cd7adns8	113	31	patients	patient	NNS
cord-023168-cd7adns8	113	32	with	with	IN
cord-023168-cd7adns8	113	33	persistent	persistent	JJ
cord-023168-cd7adns8	113	34	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	113	35	;	;	,
cord-023168-cd7adns8	113	36	initial	initial	JJ
cord-023168-cd7adns8	113	37	investigations	investigation	NNS
cord-023168-cd7adns8	113	38	should	should	MD
cord-023168-cd7adns8	113	39	be	be	VB
cord-023168-cd7adns8	113	40	determined	determine	VBN
cord-023168-cd7adns8	113	41	by	by	IN
cord-023168-cd7adns8	113	42	the	the	DT
cord-023168-cd7adns8	113	43	patient	patient	NN
cord-023168-cd7adns8	113	44	's	's	POS
cord-023168-cd7adns8	113	45	history	history	NN
cord-023168-cd7adns8	113	46	of	of	IN
cord-023168-cd7adns8	113	47	geographical	geographical	JJ
cord-023168-cd7adns8	113	48	exposure	exposure	NN
cord-023168-cd7adns8	113	49	(	(	-LRB-
cord-023168-cd7adns8	113	50	Figure	figure	NN
cord-023168-cd7adns8	113	51	65.4	65.4	CD
cord-023168-cd7adns8	113	52	)	)	-RRB-
cord-023168-cd7adns8	113	53	.	.	.
cord-023168-cd7adns8	114	1	[	[	-LRB-
cord-023168-cd7adns8	114	2	5	5	CD
cord-023168-cd7adns8	114	3	]	]	-RRB-
cord-023168-cd7adns8	114	4	[	[	-LRB-
cord-023168-cd7adns8	114	5	6	6	CD
cord-023168-cd7adns8	114	6	]	]	-RRB-
cord-023168-cd7adns8	114	7	[	[	-LRB-
cord-023168-cd7adns8	114	8	7	7	CD
cord-023168-cd7adns8	114	9	]	]	-RRB-
cord-023168-cd7adns8	115	1	The	the	DT
cord-023168-cd7adns8	115	2	absolute	absolute	JJ
cord-023168-cd7adns8	115	3	number	number	NN
cord-023168-cd7adns8	115	4	of	of	IN
cord-023168-cd7adns8	115	5	eosinophils	eosinophil	NNS
cord-023168-cd7adns8	115	6	in	in	IN
cord-023168-cd7adns8	115	7	the	the	DT
cord-023168-cd7adns8	115	8	peripheral	peripheral	JJ
cord-023168-cd7adns8	115	9	blood	blood	NN
cord-023168-cd7adns8	115	10	may	may	MD
cord-023168-cd7adns8	115	11	not	not	RB
cord-023168-cd7adns8	115	12	correlate	correlate	VB
cord-023168-cd7adns8	115	13	with	with	IN
cord-023168-cd7adns8	115	14	their	-PRON-	PRP$
cord-023168-cd7adns8	115	15	tissue	tissue	NN
cord-023168-cd7adns8	115	16	distribution	distribution	NN
cord-023168-cd7adns8	115	17	or	or	CC
cord-023168-cd7adns8	115	18	with	with	IN
cord-023168-cd7adns8	115	19	their	-PRON-	PRP$
cord-023168-cd7adns8	115	20	potential	potential	NN
cord-023168-cd7adns8	115	21	to	to	TO
cord-023168-cd7adns8	115	22	cause	cause	VB
cord-023168-cd7adns8	115	23	tissue	tissue	NN
cord-023168-cd7adns8	115	24	damage	damage	NN
cord-023168-cd7adns8	115	25	from	from	IN
cord-023168-cd7adns8	115	26	their	-PRON-	PRP$
cord-023168-cd7adns8	115	27	granule	granule	NN
cord-023168-cd7adns8	115	28	release	release	NN
cord-023168-cd7adns8	115	29	.	.	.
cord-023168-cd7adns8	116	1	This	this	DT
cord-023168-cd7adns8	116	2	is	be	VBZ
cord-023168-cd7adns8	116	3	because	because	IN
cord-023168-cd7adns8	116	4	the	the	DT
cord-023168-cd7adns8	116	5	degree	degree	NN
cord-023168-cd7adns8	116	6	of	of	IN
cord-023168-cd7adns8	116	7	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	116	8	depends	depend	VBZ
cord-023168-cd7adns8	116	9	on	on	IN
cord-023168-cd7adns8	116	10	the	the	DT
cord-023168-cd7adns8	116	11	extent	extent	NN
cord-023168-cd7adns8	116	12	of	of	IN
cord-023168-cd7adns8	116	13	tissue	tissue	NN
cord-023168-cd7adns8	116	14	invasion	invasion	NN
cord-023168-cd7adns8	116	15	and	and	CC
cord-023168-cd7adns8	116	16	is	be	VBZ
cord-023168-cd7adns8	116	17	therefore	therefore	RB
cord-023168-cd7adns8	116	18	modest	modest	JJ
cord-023168-cd7adns8	116	19	with	with	IN
cord-023168-cd7adns8	116	20	tapeworms	tapeworm	NNS
cord-023168-cd7adns8	116	21	and	and	CC
cord-023168-cd7adns8	116	22	roundworms	roundworm	NNS
cord-023168-cd7adns8	116	23	resident	resident	NN
cord-023168-cd7adns8	116	24	in	in	IN
cord-023168-cd7adns8	116	25	the	the	DT
cord-023168-cd7adns8	116	26	bowel	bowel	NN
cord-023168-cd7adns8	116	27	but	but	CC
cord-023168-cd7adns8	116	28	much	much	RB
cord-023168-cd7adns8	116	29	higher	high	JJR
cord-023168-cd7adns8	116	30	where	where	WRB
cord-023168-cd7adns8	116	31	invasion	invasion	NN
cord-023168-cd7adns8	116	32	occurs	occur	VBZ
cord-023168-cd7adns8	116	33	,	,	,
cord-023168-cd7adns8	116	34	for	for	IN
cord-023168-cd7adns8	116	35	example	example	NN
cord-023168-cd7adns8	116	36	with	with	IN
cord-023168-cd7adns8	116	37	,	,	,
cord-023168-cd7adns8	116	38	Toxocara	Toxocara	NNP
cord-023168-cd7adns8	116	39	canis	canis	NN
cord-023168-cd7adns8	116	40	or	or	CC
cord-023168-cd7adns8	116	41	filaria	filaria	NN
cord-023168-cd7adns8	116	42	.	.	.
cord-023168-cd7adns8	117	1	Schistosomiasis	Schistosomiasis	NNP
cord-023168-cd7adns8	117	2	almost	almost	RB
cord-023168-cd7adns8	117	3	always	always	RB
cord-023168-cd7adns8	117	4	causes	cause	VBZ
cord-023168-cd7adns8	117	5	eosinophilia	eosinophilia	JJ
cord-023168-cd7adns8	117	6	.	.	.
cord-023168-cd7adns8	118	1	Strongyloides	Strongyloides	NNP
cord-023168-cd7adns8	118	2	stercoralis	stercoralis	NNP
cord-023168-cd7adns8	118	3	has	have	VBZ
cord-023168-cd7adns8	118	4	the	the	DT
cord-023168-cd7adns8	118	5	capacity	capacity	NN
cord-023168-cd7adns8	118	6	to	to	TO
cord-023168-cd7adns8	118	7	remain	remain	VB
cord-023168-cd7adns8	118	8	in	in	IN
cord-023168-cd7adns8	118	9	the	the	DT
cord-023168-cd7adns8	118	10	host	host	NN
cord-023168-cd7adns8	118	11	for	for	IN
cord-023168-cd7adns8	118	12	decades	decade	NNS
cord-023168-cd7adns8	118	13	after	after	IN
cord-023168-cd7adns8	118	14	initial	initial	JJ
cord-023168-cd7adns8	118	15	infection	infection	NN
cord-023168-cd7adns8	118	16	and	and	CC
cord-023168-cd7adns8	118	17	causes	cause	NNS
cord-023168-cd7adns8	118	18	varying	vary	VBG
cord-023168-cd7adns8	118	19	degrees	degree	NNS
cord-023168-cd7adns8	118	20	of	of	IN
cord-023168-cd7adns8	118	21	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	118	22	,	,	,
cord-023168-cd7adns8	118	23	with	with	IN
cord-023168-cd7adns8	118	24	or	or	CC
cord-023168-cd7adns8	118	25	without	without	IN
cord-023168-cd7adns8	118	26	other	other	JJ
cord-023168-cd7adns8	118	27	symptoms	symptom	NNS
cord-023168-cd7adns8	118	28	.	.	.
cord-023168-cd7adns8	119	1	Steroid	steroid	NN
cord-023168-cd7adns8	119	2	treatment	treatment	NN
cord-023168-cd7adns8	119	3	,	,	,
cord-023168-cd7adns8	119	4	which	which	WDT
cord-023168-cd7adns8	119	5	may	may	MD
cord-023168-cd7adns8	119	6	be	be	VB
cord-023168-cd7adns8	119	7	necessary	necessary	JJ
cord-023168-cd7adns8	119	8	in	in	IN
cord-023168-cd7adns8	119	9	cases	case	NNS
cord-023168-cd7adns8	119	10	of	of	IN
cord-023168-cd7adns8	119	11	eosinophilic	eosinophilic	JJ
cord-023168-cd7adns8	119	12	tissue	tissue	NN
cord-023168-cd7adns8	119	13	damage	damage	NN
cord-023168-cd7adns8	119	14	,	,	,
cord-023168-cd7adns8	119	15	can	can	MD
cord-023168-cd7adns8	119	16	exacerbate	exacerbate	VB
cord-023168-cd7adns8	119	17	clinical	clinical	JJ
cord-023168-cd7adns8	119	18	problems	problem	NNS
cord-023168-cd7adns8	119	19	in	in	IN
cord-023168-cd7adns8	119	20	patients	patient	NNS
cord-023168-cd7adns8	119	21	with	with	IN
cord-023168-cd7adns8	119	22	Strongyloides	Strongyloides	NNP
cord-023168-cd7adns8	119	23	infection	infection	NN
cord-023168-cd7adns8	119	24	so	so	IN
cord-023168-cd7adns8	119	25	this	this	DT
cord-023168-cd7adns8	119	26	parasitic	parasitic	JJ
cord-023168-cd7adns8	119	27	infestation	infestation	NN
cord-023168-cd7adns8	119	28	should	should	MD
cord-023168-cd7adns8	119	29	be	be	VB
cord-023168-cd7adns8	119	30	excluded	exclude	VBN
cord-023168-cd7adns8	119	31	before	before	IN
cord-023168-cd7adns8	119	32	starting	start	VBG
cord-023168-cd7adns8	119	33	steroids	steroid	NNS
cord-023168-cd7adns8	119	34	for	for	IN
cord-023168-cd7adns8	119	35	hypereosinophilia	hypereosinophilia	NNP
cord-023168-cd7adns8	119	36	.	.	.
cord-023168-cd7adns8	120	1	Mild	mild	JJ
cord-023168-cd7adns8	120	2	to	to	IN
cord-023168-cd7adns8	120	3	moderate	moderate	JJ
cord-023168-cd7adns8	120	4	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	120	5	is	be	VBZ
cord-023168-cd7adns8	120	6	common	common	JJ
cord-023168-cd7adns8	120	7	in	in	IN
cord-023168-cd7adns8	120	8	asthma	asthma	NN
cord-023168-cd7adns8	120	9	although	although	IN
cord-023168-cd7adns8	120	10	a	a	DT
cord-023168-cd7adns8	120	11	very	very	RB
cord-023168-cd7adns8	120	12	high	high	JJ
cord-023168-cd7adns8	120	13	count	count	NN
cord-023168-cd7adns8	120	14	should	should	MD
cord-023168-cd7adns8	120	15	prompt	prompt	VB
cord-023168-cd7adns8	120	16	a	a	DT
cord-023168-cd7adns8	120	17	search	search	NN
cord-023168-cd7adns8	120	18	for	for	IN
cord-023168-cd7adns8	120	19	Churg	Churg	NNP
cord-023168-cd7adns8	120	20	-	-	HYPH
cord-023168-cd7adns8	120	21	Strauss	Strauss	NNP
cord-023168-cd7adns8	120	22	syndrome	syndrome	NN
cord-023168-cd7adns8	120	23	or	or	CC
cord-023168-cd7adns8	120	24	allergic	allergic	JJ
cord-023168-cd7adns8	120	25	bronchopulmonary	bronchopulmonary	NNP
cord-023168-cd7adns8	120	26	aspergillosis	aspergillosis	NNP
cord-023168-cd7adns8	120	27	.	.	.
cord-023168-cd7adns8	121	1	Most	Most	JJS
cord-023168-cd7adns8	121	2	drugs	drug	NNS
cord-023168-cd7adns8	121	3	including	include	VBG
cord-023168-cd7adns8	121	4	penicillins	penicillin	NNS
cord-023168-cd7adns8	121	5	can	can	MD
cord-023168-cd7adns8	121	6	cause	cause	VB
cord-023168-cd7adns8	121	7	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	121	8	but	but	CC
cord-023168-cd7adns8	121	9	the	the	DT
cord-023168-cd7adns8	121	10	diagnosis	diagnosis	NN
cord-023168-cd7adns8	121	11	can	can	MD
cord-023168-cd7adns8	121	12	only	only	RB
cord-023168-cd7adns8	121	13	be	be	VB
cord-023168-cd7adns8	121	14	made	make	VBN
cord-023168-cd7adns8	121	15	by	by	IN
cord-023168-cd7adns8	121	16	noting	note	VBG
cord-023168-cd7adns8	121	17	recovery	recovery	NN
cord-023168-cd7adns8	121	18	when	when	WRB
cord-023168-cd7adns8	121	19	the	the	DT
cord-023168-cd7adns8	121	20	drug	drug	NN
cord-023168-cd7adns8	121	21	is	be	VBZ
cord-023168-cd7adns8	121	22	discontinued	discontinue	VBN
cord-023168-cd7adns8	121	23	.	.	.
cord-023168-cd7adns8	122	1	Eosinophilia	Eosinophilia	NNP
cord-023168-cd7adns8	122	2	can	can	MD
cord-023168-cd7adns8	122	3	be	be	VB
cord-023168-cd7adns8	122	4	a	a	DT
cord-023168-cd7adns8	122	5	feature	feature	NN
cord-023168-cd7adns8	122	6	of	of	IN
cord-023168-cd7adns8	122	7	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	122	8	's	's	POS
cord-023168-cd7adns8	122	9	lymphoma	lymphoma	NN
cord-023168-cd7adns8	122	10	.	.	.
cord-023168-cd7adns8	123	1	It	-PRON-	PRP
cord-023168-cd7adns8	123	2	signifies	signify	VBZ
cord-023168-cd7adns8	123	3	a	a	DT
cord-023168-cd7adns8	123	4	more	more	RBR
cord-023168-cd7adns8	123	5	favourable	favourable	JJ
cord-023168-cd7adns8	123	6	prognosis	prognosis	NN
cord-023168-cd7adns8	123	7	and	and	CC
cord-023168-cd7adns8	123	8	may	may	MD
cord-023168-cd7adns8	123	9	precede	precede	VB
cord-023168-cd7adns8	123	10	the	the	DT
cord-023168-cd7adns8	123	11	original	original	JJ
cord-023168-cd7adns8	123	12	diagnosis	diagnosis	NN
cord-023168-cd7adns8	123	13	of	of	IN
cord-023168-cd7adns8	123	14	lymphoma	lymphoma	NN
cord-023168-cd7adns8	123	15	or	or	CC
cord-023168-cd7adns8	123	16	relapses	relapse	NNS
cord-023168-cd7adns8	123	17	.	.	.
cord-023168-cd7adns8	124	1	In	in	IN
cord-023168-cd7adns8	124	2	immunocompromised	immunocompromised	JJ
cord-023168-cd7adns8	124	3	patients	patient	NNS
cord-023168-cd7adns8	124	4	,	,	,
cord-023168-cd7adns8	124	5	such	such	JJ
cord-023168-cd7adns8	124	6	as	as	IN
cord-023168-cd7adns8	124	7	those	those	DT
cord-023168-cd7adns8	124	8	with	with	IN
cord-023168-cd7adns8	124	9	HIV	HIV	NNP
cord-023168-cd7adns8	124	10	infection	infection	NN
cord-023168-cd7adns8	124	11	,	,	,
cord-023168-cd7adns8	124	12	the	the	DT
cord-023168-cd7adns8	124	13	finding	finding	NN
cord-023168-cd7adns8	124	14	of	of	IN
cord-023168-cd7adns8	124	15	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	124	16	may	may	MD
cord-023168-cd7adns8	124	17	be	be	VB
cord-023168-cd7adns8	124	18	crucial	crucial	JJ
cord-023168-cd7adns8	124	19	since	since	IN
cord-023168-cd7adns8	124	20	the	the	DT
cord-023168-cd7adns8	124	21	success	success	NN
cord-023168-cd7adns8	124	22	of	of	IN
cord-023168-cd7adns8	124	23	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	124	24	treatment	treatment	NN
cord-023168-cd7adns8	124	25	may	may	MD
cord-023168-cd7adns8	124	26	depend	depend	VB
cord-023168-cd7adns8	124	27	on	on	IN
cord-023168-cd7adns8	124	28	concomitant	concomitant	JJ
cord-023168-cd7adns8	124	29	eradication	eradication	NN
cord-023168-cd7adns8	124	30	of	of	IN
cord-023168-cd7adns8	124	31	parasites	parasite	NNS
cord-023168-cd7adns8	124	32	.	.	.
cord-023168-cd7adns8	124	33	 	 	_SP
cord-023168-cd7adns8	125	1	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	125	2	is	be	VBZ
cord-023168-cd7adns8	125	3	often	often	RB
cord-023168-cd7adns8	125	4	discovered	discover	VBN
cord-023168-cd7adns8	125	5	incidentally	incidentally	RB
cord-023168-cd7adns8	125	6	in	in	IN
cord-023168-cd7adns8	125	7	patients	patient	NNS
cord-023168-cd7adns8	125	8	during	during	IN
cord-023168-cd7adns8	125	9	full	full	JJ
cord-023168-cd7adns8	125	10	blood	blood	NN
cord-023168-cd7adns8	125	11	count	count	NN
cord-023168-cd7adns8	125	12	estimation	estimation	NN
cord-023168-cd7adns8	125	13	.	.	.
cord-023168-cd7adns8	126	1	A	a	DT
cord-023168-cd7adns8	126	2	platelet	platelet	NN
cord-023168-cd7adns8	126	3	count	count	NN
cord-023168-cd7adns8	126	4	above	above	IN
cord-023168-cd7adns8	126	5	20	20	CD
cord-023168-cd7adns8	126	6	-	-	SYM
cord-023168-cd7adns8	126	7	30	30	CD
cord-023168-cd7adns8	126	8	×	×	NN
cord-023168-cd7adns8	126	9	10	10	CD
cord-023168-cd7adns8	126	10	9	9	CD
cord-023168-cd7adns8	126	11	/L	/L	.
cord-023168-cd7adns8	126	12	is	be	VBZ
cord-023168-cd7adns8	126	13	usually	usually	RB
cord-023168-cd7adns8	126	14	not	not	RB
cord-023168-cd7adns8	126	15	associated	associate	VBN
cord-023168-cd7adns8	126	16	with	with	IN
cord-023168-cd7adns8	126	17	any	any	DT
cord-023168-cd7adns8	126	18	symptoms	symptom	NNS
cord-023168-cd7adns8	126	19	such	such	JJ
cord-023168-cd7adns8	126	20	as	as	IN
cord-023168-cd7adns8	126	21	bleeding	bleed	VBG
cord-023168-cd7adns8	126	22	.	.	.
cord-023168-cd7adns8	127	1	If	if	IN
cord-023168-cd7adns8	127	2	clinically	clinically	RB
cord-023168-cd7adns8	127	3	evident	evident	JJ
cord-023168-cd7adns8	127	4	haemorrhage	haemorrhage	NN
cord-023168-cd7adns8	127	5	does	do	VBZ
cord-023168-cd7adns8	127	6	occur	occur	VB
cord-023168-cd7adns8	127	7	at	at	IN
cord-023168-cd7adns8	127	8	counts	count	NNS
cord-023168-cd7adns8	127	9	above	above	IN
cord-023168-cd7adns8	127	10	this	this	DT
cord-023168-cd7adns8	127	11	level	level	NN
cord-023168-cd7adns8	127	12	,	,	,
cord-023168-cd7adns8	127	13	other	other	JJ
cord-023168-cd7adns8	127	14	conditions	condition	NNS
cord-023168-cd7adns8	127	15	such	such	JJ
cord-023168-cd7adns8	127	16	as	as	IN
cord-023168-cd7adns8	127	17	coagulation	coagulation	NN
cord-023168-cd7adns8	127	18	defects	defect	NNS
cord-023168-cd7adns8	127	19	,	,	,
cord-023168-cd7adns8	127	20	vascular	vascular	JJ
cord-023168-cd7adns8	127	21	problems	problem	NNS
cord-023168-cd7adns8	127	22	or	or	CC
cord-023168-cd7adns8	127	23	rarely	rarely	RB
cord-023168-cd7adns8	127	24	platelet	platelet	JJ
cord-023168-cd7adns8	127	25	dysfunction	dysfunction	NN
cord-023168-cd7adns8	127	26	should	should	MD
cord-023168-cd7adns8	127	27	be	be	VB
cord-023168-cd7adns8	127	28	suspected	suspect	VBN
cord-023168-cd7adns8	127	29	.	.	.
cord-023168-cd7adns8	128	1	Although	although	IN
cord-023168-cd7adns8	128	2	the	the	DT
cord-023168-cd7adns8	128	3	prime	prime	JJ
cord-023168-cd7adns8	128	4	role	role	NN
cord-023168-cd7adns8	128	5	of	of	IN
cord-023168-cd7adns8	128	6	platelets	platelet	NNS
cord-023168-cd7adns8	128	7	is	be	VBZ
cord-023168-cd7adns8	128	8	in	in	IN
cord-023168-cd7adns8	128	9	haemostasis	haemostasis	NN
cord-023168-cd7adns8	128	10	,	,	,
cord-023168-cd7adns8	128	11	several	several	JJ
cord-023168-cd7adns8	128	12	other	other	JJ
cord-023168-cd7adns8	128	13	important	important	JJ
cord-023168-cd7adns8	128	14	roles	role	NNS
cord-023168-cd7adns8	128	15	have	have	VBP
cord-023168-cd7adns8	128	16	been	be	VBN
cord-023168-cd7adns8	128	17	recognized	recognize	VBN
cord-023168-cd7adns8	128	18	in	in	IN
cord-023168-cd7adns8	128	19	recent	recent	JJ
cord-023168-cd7adns8	128	20	years	year	NNS
cord-023168-cd7adns8	128	21	including	include	VBG
cord-023168-cd7adns8	128	22	wound	wound	NN
cord-023168-cd7adns8	128	23	repair	repair	NN
cord-023168-cd7adns8	128	24	,	,	,
cord-023168-cd7adns8	128	25	tissue	tissue	NN
cord-023168-cd7adns8	128	26	healing	healing	NN
cord-023168-cd7adns8	128	27	,	,	,
cord-023168-cd7adns8	128	28	antimicrobicidal	antimicrobicidal	JJ
cord-023168-cd7adns8	128	29	properties	property	NNS
cord-023168-cd7adns8	128	30	,	,	,
cord-023168-cd7adns8	128	31	lymphangiogenesis	lymphangiogenesis	NNP
cord-023168-cd7adns8	128	32	,	,	,
cord-023168-cd7adns8	128	33	tumour	tumour	NN
cord-023168-cd7adns8	128	34	metastasization	metastasization	NN
cord-023168-cd7adns8	128	35	and	and	CC
cord-023168-cd7adns8	128	36	maintenance	maintenance	NN
cord-023168-cd7adns8	128	37	of	of	IN
cord-023168-cd7adns8	128	38	blood	blood	NN
cord-023168-cd7adns8	128	39	vessel	vessel	NN
cord-023168-cd7adns8	128	40	integrity	integrity	NN
cord-023168-cd7adns8	128	41	.	.	.
cord-023168-cd7adns8	129	1	Congenital	congenital	JJ
cord-023168-cd7adns8	129	2	platelet	platelet	NN
cord-023168-cd7adns8	129	3	disorders	disorder	NNS
cord-023168-cd7adns8	129	4	are	be	VBP
cord-023168-cd7adns8	129	5	often	often	RB
cord-023168-cd7adns8	129	6	part	part	NN
cord-023168-cd7adns8	129	7	of	of	IN
cord-023168-cd7adns8	129	8	a	a	DT
cord-023168-cd7adns8	129	9	syndrome	syndrome	NN
cord-023168-cd7adns8	129	10	.	.	.
cord-023168-cd7adns8	130	1	Patients	patient	NNS
cord-023168-cd7adns8	130	2	with	with	IN
cord-023168-cd7adns8	130	3	Wiskott	Wiskott	NNP
cord-023168-cd7adns8	130	4	-	-	HYPH
cord-023168-cd7adns8	130	5	Aldrich	Aldrich	NNP
cord-023168-cd7adns8	130	6	syndrome	syndrome	NN
cord-023168-cd7adns8	130	7	have	have	VBP
cord-023168-cd7adns8	130	8	small	small	JJ
cord-023168-cd7adns8	130	9	platelets	platelet	NNS
cord-023168-cd7adns8	130	10	in	in	IN
cord-023168-cd7adns8	130	11	association	association	NN
cord-023168-cd7adns8	130	12	with	with	IN
cord-023168-cd7adns8	130	13	eczema	eczema	NN
cord-023168-cd7adns8	130	14	and	and	CC
cord-023168-cd7adns8	130	15	recurrent	recurrent	JJ
cord-023168-cd7adns8	130	16	infections	infection	NNS
cord-023168-cd7adns8	130	17	.	.	.
cord-023168-cd7adns8	131	1	Other	other	JJ
cord-023168-cd7adns8	131	2	congenital	congenital	JJ
cord-023168-cd7adns8	131	3	platelet	platelet	NN
cord-023168-cd7adns8	131	4	disorders	disorder	NNS
cord-023168-cd7adns8	131	5	,	,	,
cord-023168-cd7adns8	131	6	such	such	JJ
cord-023168-cd7adns8	131	7	as	as	IN
cord-023168-cd7adns8	131	8	MYH9-related	myh9-relate	VBN
cord-023168-cd7adns8	131	9	disorders	disorder	NNS
cord-023168-cd7adns8	131	10	,	,	,
cord-023168-cd7adns8	131	11	can	can	MD
cord-023168-cd7adns8	131	12	present	present	VB
cord-023168-cd7adns8	131	13	with	with	IN
cord-023168-cd7adns8	131	14	deafness	deafness	NN
cord-023168-cd7adns8	131	15	or	or	CC
cord-023168-cd7adns8	131	16	cataracts	cataract	NNS
cord-023168-cd7adns8	131	17	while	while	IN
cord-023168-cd7adns8	131	18	skeletal	skeletal	JJ
cord-023168-cd7adns8	131	19	deformities	deformity	NNS
cord-023168-cd7adns8	131	20	and	and	CC
cord-023168-cd7adns8	131	21	oculocutaneous	oculocutaneous	JJ
cord-023168-cd7adns8	131	22	albinism	albinism	NN
cord-023168-cd7adns8	131	23	are	be	VBP
cord-023168-cd7adns8	131	24	common	common	JJ
cord-023168-cd7adns8	131	25	in	in	IN
cord-023168-cd7adns8	131	26	other	other	JJ
cord-023168-cd7adns8	131	27	syndromic	syndromic	JJ
cord-023168-cd7adns8	131	28	presentations	presentation	NNS
cord-023168-cd7adns8	131	29	.	.	.
cord-023168-cd7adns8	132	1	Blood	blood	NN
cord-023168-cd7adns8	132	2	film	film	NN
cord-023168-cd7adns8	132	3	morphology	morphology	NN
cord-023168-cd7adns8	132	4	can	can	MD
cord-023168-cd7adns8	132	5	provide	provide	VB
cord-023168-cd7adns8	132	6	important	important	JJ
cord-023168-cd7adns8	132	7	clues	clue	NNS
cord-023168-cd7adns8	132	8	about	about	IN
cord-023168-cd7adns8	132	9	the	the	DT
cord-023168-cd7adns8	132	10	causes	cause	NNS
cord-023168-cd7adns8	132	11	of	of	IN
cord-023168-cd7adns8	132	12	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	132	13	(	(	-LRB-
cord-023168-cd7adns8	132	14	Figure	figure	NN
cord-023168-cd7adns8	132	15	65	65	CD
cord-023168-cd7adns8	132	16	.5	.5	CD
cord-023168-cd7adns8	132	17	)	)	-RRB-
cord-023168-cd7adns8	132	18	.	.	.
cord-023168-cd7adns8	133	1	Fragmented	fragmented	JJ
cord-023168-cd7adns8	133	2	red	red	JJ
cord-023168-cd7adns8	133	3	cells	cell	NNS
cord-023168-cd7adns8	133	4	(	(	-LRB-
cord-023168-cd7adns8	133	5	schistocytes	schistocytes	NNP
cord-023168-cd7adns8	133	6	)	)	-RRB-
cord-023168-cd7adns8	133	7	increase	increase	VB
cord-023168-cd7adns8	133	8	the	the	DT
cord-023168-cd7adns8	133	9	possibility	possibility	NN
cord-023168-cd7adns8	133	10	of	of	IN
cord-023168-cd7adns8	133	11	microangiopathic	microangiopathic	JJ
cord-023168-cd7adns8	133	12	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	133	13	anaemia	anaemia	NN
cord-023168-cd7adns8	133	14	,	,	,
cord-023168-cd7adns8	133	15	where	where	WRB
cord-023168-cd7adns8	133	16	an	an	DT
cord-023168-cd7adns8	133	17	altered	altered	JJ
cord-023168-cd7adns8	133	18	vessel	vessel	NN
cord-023168-cd7adns8	133	19	wall	wall	NN
cord-023168-cd7adns8	133	20	and	and	CC
cord-023168-cd7adns8	133	21	fibrin	fibrin	NN
cord-023168-cd7adns8	133	22	formation	formation	NN
cord-023168-cd7adns8	133	23	in	in	IN
cord-023168-cd7adns8	133	24	the	the	DT
cord-023168-cd7adns8	133	25	blood	blood	NN
cord-023168-cd7adns8	133	26	vessels	vessel	NNS
cord-023168-cd7adns8	133	27	shred	shred	VBP
cord-023168-cd7adns8	133	28	the	the	DT
cord-023168-cd7adns8	133	29	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	133	30	and	and	CC
cord-023168-cd7adns8	133	31	consume	consume	VBP
cord-023168-cd7adns8	133	32	platelets	platelet	NNS
cord-023168-cd7adns8	133	33	.	.	.
cord-023168-cd7adns8	134	1	Thrombotic	thrombotic	JJ
cord-023168-cd7adns8	134	2	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	134	3	purpura	purpura	NN
cord-023168-cd7adns8	134	4	,	,	,
cord-023168-cd7adns8	134	5	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	134	6	uremic	uremic	JJ
cord-023168-cd7adns8	134	7	syndrome	syndrome	NN
cord-023168-cd7adns8	134	8	and	and	CC
cord-023168-cd7adns8	134	9	disseminated	disseminate	VBN
cord-023168-cd7adns8	134	10	intravascular	intravascular	JJ
cord-023168-cd7adns8	134	11	coagulation	coagulation	NN
cord-023168-cd7adns8	134	12	can	can	MD
cord-023168-cd7adns8	134	13	all	all	DT
cord-023168-cd7adns8	134	14	present	present	JJ
cord-023168-cd7adns8	134	15	with	with	IN
cord-023168-cd7adns8	134	16	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	134	17	.	.	.
cord-023168-cd7adns8	135	1	Dysplastic	dysplastic	JJ
cord-023168-cd7adns8	135	2	red	red	JJ
cord-023168-cd7adns8	135	3	or	or	CC
cord-023168-cd7adns8	135	4	white	white	JJ
cord-023168-cd7adns8	135	5	cells	cell	NNS
cord-023168-cd7adns8	135	6	should	should	MD
cord-023168-cd7adns8	135	7	raise	raise	VB
cord-023168-cd7adns8	135	8	the	the	DT
cord-023168-cd7adns8	135	9	suspicion	suspicion	NN
cord-023168-cd7adns8	135	10	of	of	IN
cord-023168-cd7adns8	135	11	myelodysplasia	myelodysplasia	NNP
cord-023168-cd7adns8	135	12	which	which	WDT
cord-023168-cd7adns8	135	13	can	can	MD
cord-023168-cd7adns8	135	14	be	be	VB
cord-023168-cd7adns8	135	15	confirmed	confirm	VBN
cord-023168-cd7adns8	135	16	by	by	IN
cord-023168-cd7adns8	135	17	bone	bone	NN
cord-023168-cd7adns8	135	18	marrow	marrow	NN
cord-023168-cd7adns8	135	19	examination	examination	NN
cord-023168-cd7adns8	135	20	and	and	CC
cord-023168-cd7adns8	135	21	cytogenetic	cytogenetic	JJ
cord-023168-cd7adns8	135	22	analysis	analysis	NN
cord-023168-cd7adns8	135	23	.	.	.
cord-023168-cd7adns8	136	1	It	-PRON-	PRP
cord-023168-cd7adns8	136	2	is	be	VBZ
cord-023168-cd7adns8	136	3	important	important	JJ
cord-023168-cd7adns8	136	4	to	to	TO
cord-023168-cd7adns8	136	5	exclude	exclude	VB
cord-023168-cd7adns8	136	6	in	in	IN
cord-023168-cd7adns8	136	7	vitro	vitro	FW
cord-023168-cd7adns8	136	8	platelet	platelet	NN
cord-023168-cd7adns8	136	9	agglutination	agglutination	NN
cord-023168-cd7adns8	136	10	as	as	IN
cord-023168-cd7adns8	136	11	a	a	DT
cord-023168-cd7adns8	136	12	cause	cause	NN
cord-023168-cd7adns8	136	13	for	for	IN
cord-023168-cd7adns8	136	14	apparent	apparent	JJ
cord-023168-cd7adns8	136	15	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	136	16	.	.	.
cord-023168-cd7adns8	137	1	This	this	DT
cord-023168-cd7adns8	137	2	can	can	MD
cord-023168-cd7adns8	137	3	be	be	VB
cord-023168-cd7adns8	137	4	an	an	DT
cord-023168-cd7adns8	137	5	anticoagulant	anticoagulant	NN
cord-023168-cd7adns8	137	6	(	(	-LRB-
cord-023168-cd7adns8	137	7	EDTA)-dependent	edta)-dependent	NN
cord-023168-cd7adns8	137	8	phenomenon	phenomenon	NN
cord-023168-cd7adns8	137	9	so	so	IN
cord-023168-cd7adns8	137	10	a	a	DT
cord-023168-cd7adns8	137	11	repeat	repeat	NN
cord-023168-cd7adns8	137	12	sample	sample	NN
cord-023168-cd7adns8	137	13	should	should	MD
cord-023168-cd7adns8	137	14	be	be	VB
cord-023168-cd7adns8	137	15	examined	examine	VBN
cord-023168-cd7adns8	137	16	using	use	VBG
cord-023168-cd7adns8	137	17	citrate	citrate	NN
cord-023168-cd7adns8	137	18	anticoagulant	anticoagulant	NN
cord-023168-cd7adns8	137	19	.	.	.
cord-023168-cd7adns8	138	1	Rarely	rarely	RB
cord-023168-cd7adns8	138	2	,	,	,
cord-023168-cd7adns8	138	3	platelet	platelet	NN
cord-023168-cd7adns8	138	4	satellitism	satellitism	NN
cord-023168-cd7adns8	138	5	where	where	WRB
cord-023168-cd7adns8	138	6	the	the	DT
cord-023168-cd7adns8	138	7	platelets	platelet	NNS
cord-023168-cd7adns8	138	8	clump	clump	VBP
cord-023168-cd7adns8	138	9	round	round	IN
cord-023168-cd7adns8	138	10	the	the	DT
cord-023168-cd7adns8	138	11	neutrophils	neutrophil	NNS
cord-023168-cd7adns8	138	12	,	,	,
cord-023168-cd7adns8	138	13	can	can	MD
cord-023168-cd7adns8	138	14	cause	cause	VB
cord-023168-cd7adns8	138	15	artefactual	artefactual	JJ
cord-023168-cd7adns8	138	16	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	138	17	.	.	.
cord-023168-cd7adns8	139	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	139	2	affects	affect	VBZ
cord-023168-cd7adns8	139	3	nearly	nearly	RB
cord-023168-cd7adns8	139	4	two	two	CD
cord-023168-cd7adns8	139	5	billion	billion	CD
cord-023168-cd7adns8	139	6	people	people	NNS
cord-023168-cd7adns8	139	7	globally	globally	RB
cord-023168-cd7adns8	139	8	with	with	IN
cord-023168-cd7adns8	139	9	a	a	DT
cord-023168-cd7adns8	139	10	much	much	RB
cord-023168-cd7adns8	139	11	higher	high	JJR
cord-023168-cd7adns8	139	12	prevalence	prevalence	NN
cord-023168-cd7adns8	139	13	in	in	IN
cord-023168-cd7adns8	139	14	developing	develop	VBG
cord-023168-cd7adns8	139	15	countries	country	NNS
cord-023168-cd7adns8	139	16	compared	compare	VBN
cord-023168-cd7adns8	139	17	with	with	IN
cord-023168-cd7adns8	139	18	more	more	JJR
cord-023168-cd7adns8	139	19	wealthy	wealthy	JJ
cord-023168-cd7adns8	139	20	nations	nation	NNS
cord-023168-cd7adns8	139	21	(	(	-LRB-
cord-023168-cd7adns8	139	22	43	43	CD
cord-023168-cd7adns8	139	23	%	%	NN
cord-023168-cd7adns8	139	24	vs	vs	IN
cord-023168-cd7adns8	139	25	9	9	CD
cord-023168-cd7adns8	139	26	%	%	NN
cord-023168-cd7adns8	139	27	)	)	-RRB-
cord-023168-cd7adns8	139	28	.	.	.
cord-023168-cd7adns8	140	1	8	8	CD
cord-023168-cd7adns8	141	1	The	the	DT
cord-023168-cd7adns8	141	2	continents	continent	NNS
cord-023168-cd7adns8	141	3	of	of	IN
cord-023168-cd7adns8	141	4	Africa	Africa	NNP
cord-023168-cd7adns8	141	5	(	(	-LRB-
cord-023168-cd7adns8	141	6	highest	high	JJS
cord-023168-cd7adns8	141	7	prevalence	prevalence	NN
cord-023168-cd7adns8	141	8	)	)	-RRB-
cord-023168-cd7adns8	141	9	and	and	CC
cord-023168-cd7adns8	141	10	Asia	Asia	NNP
cord-023168-cd7adns8	141	11	(	(	-LRB-
cord-023168-cd7adns8	141	12	greatest	great	JJS
cord-023168-cd7adns8	141	13	absolute	absolute	JJ
cord-023168-cd7adns8	141	14	burden	burden	NN
cord-023168-cd7adns8	141	15	)	)	-RRB-
cord-023168-cd7adns8	141	16	account	account	VBP
cord-023168-cd7adns8	141	17	for	for	IN
cord-023168-cd7adns8	141	18	more	more	JJR
cord-023168-cd7adns8	141	19	than	than	IN
cord-023168-cd7adns8	141	20	85	85	CD
cord-023168-cd7adns8	141	21	%	%	NN
cord-023168-cd7adns8	141	22	of	of	IN
cord-023168-cd7adns8	141	23	the	the	DT
cord-023168-cd7adns8	141	24	anaemic	anaemic	JJ
cord-023168-cd7adns8	141	25	population	population	NN
cord-023168-cd7adns8	141	26	.	.	.
cord-023168-cd7adns8	142	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	142	2	burden	burden	NN
cord-023168-cd7adns8	142	3	is	be	VBZ
cord-023168-cd7adns8	142	4	highest	high	JJS
cord-023168-cd7adns8	142	5	among	among	IN
cord-023168-cd7adns8	142	6	children	child	NNS
cord-023168-cd7adns8	142	7	and	and	CC
cord-023168-cd7adns8	142	8	women	woman	NNS
cord-023168-cd7adns8	142	9	of	of	IN
cord-023168-cd7adns8	142	10	reproductive	reproductive	JJ
cord-023168-cd7adns8	142	11	age	age	NN
cord-023168-cd7adns8	142	12	.	.	.
cord-023168-cd7adns8	143	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	143	2	contributes	contribute	VBZ
cord-023168-cd7adns8	143	3	to	to	IN
cord-023168-cd7adns8	143	4	more	more	JJR
cord-023168-cd7adns8	143	5	than	than	IN
cord-023168-cd7adns8	143	6	115	115	CD
cord-023168-cd7adns8	143	7	000	000	CD
cord-023168-cd7adns8	143	8	maternal	maternal	JJ
cord-023168-cd7adns8	143	9	deaths	death	NNS
cord-023168-cd7adns8	143	10	and	and	CC
cord-023168-cd7adns8	143	11	591	591	CD
cord-023168-cd7adns8	143	12	000	000	CD
cord-023168-cd7adns8	143	13	perinatal	perinatal	JJ
cord-023168-cd7adns8	143	14	deaths	death	NNS
cord-023168-cd7adns8	143	15	globally	globally	RB
cord-023168-cd7adns8	143	16	per	per	IN
cord-023168-cd7adns8	143	17	year	year	NN
cord-023168-cd7adns8	143	18	.	.	.
cord-023168-cd7adns8	144	1	9	9	LS
cord-023168-cd7adns8	144	2	WHO	who	WP
cord-023168-cd7adns8	144	3	have	have	VBP
cord-023168-cd7adns8	144	4	defined	define	VBN
cord-023168-cd7adns8	144	5	anaemia	anaemia	NN
cord-023168-cd7adns8	144	6	according	accord	VBG
cord-023168-cd7adns8	144	7	to	to	IN
cord-023168-cd7adns8	144	8	various	various	JJ
cord-023168-cd7adns8	144	9	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	144	10	concentrations	concentration	NNS
cord-023168-cd7adns8	144	11	(	(	-LRB-
cord-023168-cd7adns8	144	12	Table	table	NN
cord-023168-cd7adns8	144	13	65	65	CD
cord-023168-cd7adns8	144	14	.	.	.
cord-023168-cd7adns8	144	15	2	2	CD
cord-023168-cd7adns8	144	16	)	)	-RRB-
cord-023168-cd7adns8	144	17	10	10	CD
cord-023168-cd7adns8	144	18	but	but	CC
cord-023168-cd7adns8	144	19	the	the	DT
cord-023168-cd7adns8	144	20	appropriateness	appropriateness	NN
cord-023168-cd7adns8	144	21	of	of	IN
cord-023168-cd7adns8	144	22	these	these	DT
cord-023168-cd7adns8	144	23	thresholds	threshold	NNS
cord-023168-cd7adns8	144	24	has	have	VBZ
cord-023168-cd7adns8	144	25	been	be	VBN
cord-023168-cd7adns8	144	26	questioned	question	VBN
cord-023168-cd7adns8	144	27	because	because	IN
cord-023168-cd7adns8	144	28	there	there	EX
cord-023168-cd7adns8	144	29	are	be	VBP
cord-023168-cd7adns8	144	30	wide	wide	JJ
cord-023168-cd7adns8	144	31	variations	variation	NNS
cord-023168-cd7adns8	144	32	in	in	IN
cord-023168-cd7adns8	144	33	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	144	34	concentration	concentration	NN
cord-023168-cd7adns8	144	35	among	among	IN
cord-023168-cd7adns8	144	36	people	people	NNS
cord-023168-cd7adns8	144	37	of	of	IN
cord-023168-cd7adns8	144	38	different	different	JJ
cord-023168-cd7adns8	144	39	races	race	NNS
cord-023168-cd7adns8	144	40	.	.	.
cord-023168-cd7adns8	145	1	11	11	CD
cord-023168-cd7adns8	146	1	The	the	DT
cord-023168-cd7adns8	146	2	prevalence	prevalence	NN
cord-023168-cd7adns8	146	3	of	of	IN
cord-023168-cd7adns8	146	4	anaemia	anaemia	NN
cord-023168-cd7adns8	146	5	can	can	MD
cord-023168-cd7adns8	146	6	be	be	VB
cord-023168-cd7adns8	146	7	a	a	DT
cord-023168-cd7adns8	146	8	useful	useful	JJ
cord-023168-cd7adns8	146	9	indicator	indicator	NN
cord-023168-cd7adns8	146	10	of	of	IN
cord-023168-cd7adns8	146	11	public	public	JJ
cord-023168-cd7adns8	146	12	health	health	NN
cord-023168-cd7adns8	146	13	status	status	NN
cord-023168-cd7adns8	146	14	of	of	IN
cord-023168-cd7adns8	146	15	a	a	DT
cord-023168-cd7adns8	146	16	nation	nation	NN
cord-023168-cd7adns8	146	17	because	because	IN
cord-023168-cd7adns8	146	18	:	:	:
cord-023168-cd7adns8	146	19	•	•	NNP
cord-023168-cd7adns8	146	20	The	the	DT
cord-023168-cd7adns8	146	21	prevalence	prevalence	NN
cord-023168-cd7adns8	146	22	of	of	IN
cord-023168-cd7adns8	146	23	anaemia	anaemia	NN
cord-023168-cd7adns8	146	24	is	be	VBZ
cord-023168-cd7adns8	146	25	objective	objective	JJ
cord-023168-cd7adns8	146	26	and	and	CC
cord-023168-cd7adns8	146	27	quantifiable	quantifiable	JJ
cord-023168-cd7adns8	146	28	•	•	NNS
cord-023168-cd7adns8	147	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	147	2	is	be	VBZ
cord-023168-cd7adns8	147	3	a	a	DT
cord-023168-cd7adns8	147	4	major	major	JJ
cord-023168-cd7adns8	147	5	complication	complication	NN
cord-023168-cd7adns8	147	6	of	of	IN
cord-023168-cd7adns8	147	7	several	several	JJ
cord-023168-cd7adns8	147	8	infections	infection	NNS
cord-023168-cd7adns8	147	9	,	,	,
cord-023168-cd7adns8	147	10	including	include	VBG
cord-023168-cd7adns8	147	11	malaria	malaria	NN
cord-023168-cd7adns8	147	12	,	,	,
cord-023168-cd7adns8	147	13	HIV	HIV	NNP
cord-023168-cd7adns8	147	14	,	,	,
cord-023168-cd7adns8	147	15	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	147	16	,	,	,
cord-023168-cd7adns8	147	17	and	and	CC
cord-023168-cd7adns8	147	18	the	the	DT
cord-023168-cd7adns8	147	19	neglected	neglect	VBN
cord-023168-cd7adns8	147	20	tropical	tropical	JJ
cord-023168-cd7adns8	147	21	diseases	disease	NNS
cord-023168-cd7adns8	147	22	,	,	,
cord-023168-cd7adns8	147	23	which	which	WDT
cord-023168-cd7adns8	147	24	are	be	VBP
cord-023168-cd7adns8	147	25	among	among	IN
cord-023168-cd7adns8	147	26	the	the	DT
cord-023168-cd7adns8	147	27	commonest	common	JJS
cord-023168-cd7adns8	147	28	problems	problem	NNS
cord-023168-cd7adns8	147	29	in	in	IN
cord-023168-cd7adns8	147	30	most	most	JJS
cord-023168-cd7adns8	147	31	tropical	tropical	JJ
cord-023168-cd7adns8	147	32	countries	country	NNS
cord-023168-cd7adns8	148	1	•	•	NNP
cord-023168-cd7adns8	149	1	The	the	DT
cord-023168-cd7adns8	149	2	incidence	incidence	NN
cord-023168-cd7adns8	149	3	of	of	IN
cord-023168-cd7adns8	149	4	anaemia	anaemia	NN
cord-023168-cd7adns8	149	5	changes	change	VBZ
cord-023168-cd7adns8	149	6	in	in	IN
cord-023168-cd7adns8	149	7	a	a	DT
cord-023168-cd7adns8	149	8	predictable	predictable	JJ
cord-023168-cd7adns8	149	9	fashion	fashion	NN
cord-023168-cd7adns8	149	10	with	with	IN
cord-023168-cd7adns8	149	11	alterations	alteration	NNS
cord-023168-cd7adns8	149	12	in	in	IN
cord-023168-cd7adns8	149	13	disease	disease	NN
cord-023168-cd7adns8	149	14	burden	burden	NN
cord-023168-cd7adns8	150	1	•	•	NNP
cord-023168-cd7adns8	151	1	The	the	DT
cord-023168-cd7adns8	151	2	prevalence	prevalence	NN
cord-023168-cd7adns8	151	3	of	of	IN
cord-023168-cd7adns8	151	4	anaemia	anaemia	NN
cord-023168-cd7adns8	151	5	can	can	MD
cord-023168-cd7adns8	151	6	be	be	VB
cord-023168-cd7adns8	151	7	used	use	VBN
cord-023168-cd7adns8	151	8	to	to	TO
cord-023168-cd7adns8	151	9	assess	assess	VB
cord-023168-cd7adns8	151	10	whether	whether	IN
cord-023168-cd7adns8	151	11	an	an	DT
cord-023168-cd7adns8	151	12	intervention	intervention	NN
cord-023168-cd7adns8	151	13	has	have	VBZ
cord-023168-cd7adns8	151	14	reached	reach	VBN
cord-023168-cd7adns8	151	15	the	the	DT
cord-023168-cd7adns8	151	16	poorest	poor	JJS
cord-023168-cd7adns8	151	17	communities	community	NNS
cord-023168-cd7adns8	151	18	.	.	.
cord-023168-cd7adns8	152	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	152	2	concentration	concentration	NN
cord-023168-cd7adns8	152	3	of	of	IN
cord-023168-cd7adns8	152	4	<	<	XX
cord-023168-cd7adns8	152	5	90	90	CD
cord-023168-cd7adns8	152	6	g	g	NN
cord-023168-cd7adns8	152	7	/	/	SYM
cord-023168-cd7adns8	152	8	L	L	NNP
cord-023168-cd7adns8	152	9	has	have	VBZ
cord-023168-cd7adns8	152	10	been	be	VBN
cord-023168-cd7adns8	152	11	recommended	recommend	VBN
cord-023168-cd7adns8	152	12	for	for	IN
cord-023168-cd7adns8	152	13	disease	disease	NN
cord-023168-cd7adns8	152	14	surveillance	surveillance	NN
cord-023168-cd7adns8	152	15	in	in	IN
cord-023168-cd7adns8	152	16	high	high	JJ
cord-023168-cd7adns8	152	17	-	-	HYPH
cord-023168-cd7adns8	152	18	prevalence	prevalence	NN
cord-023168-cd7adns8	152	19	countries	country	NNS
cord-023168-cd7adns8	152	20	where	where	WRB
cord-023168-cd7adns8	152	21	changes	change	NNS
cord-023168-cd7adns8	152	22	in	in	IN
cord-023168-cd7adns8	152	23	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	152	24	are	be	VBP
cord-023168-cd7adns8	152	25	used	use	VBN
cord-023168-cd7adns8	152	26	for	for	IN
cord-023168-cd7adns8	152	27	monitoring	monitor	VBG
cord-023168-cd7adns8	152	28	the	the	DT
cord-023168-cd7adns8	152	29	impact	impact	NN
cord-023168-cd7adns8	152	30	of	of	IN
cord-023168-cd7adns8	152	31	interventions	intervention	NNS
cord-023168-cd7adns8	152	32	.	.	.
cord-023168-cd7adns8	153	1	11	11	CD
cord-023168-cd7adns8	153	2	Anaemia	anaemia	NN
cord-023168-cd7adns8	153	3	in	in	IN
cord-023168-cd7adns8	153	4	tropical	tropical	JJ
cord-023168-cd7adns8	153	5	countries	country	NNS
cord-023168-cd7adns8	153	6	(	(	-LRB-
cord-023168-cd7adns8	153	7	Box	Box	NNP
cord-023168-cd7adns8	153	8	65.3	65.3	CD
cord-023168-cd7adns8	153	9	)	)	-RRB-
cord-023168-cd7adns8	153	10	is	be	VBZ
cord-023168-cd7adns8	153	11	often	often	RB
cord-023168-cd7adns8	153	12	due	due	JJ
cord-023168-cd7adns8	153	13	to	to	IN
cord-023168-cd7adns8	153	14	infections	infection	NNS
cord-023168-cd7adns8	153	15	but	but	CC
cord-023168-cd7adns8	153	16	chronic	chronic	JJ
cord-023168-cd7adns8	153	17	health	health	NN
cord-023168-cd7adns8	153	18	problems	problem	NNS
cord-023168-cd7adns8	153	19	,	,	,
cord-023168-cd7adns8	153	20	such	such	JJ
cord-023168-cd7adns8	153	21	as	as	IN
cord-023168-cd7adns8	153	22	diabetes	diabetes	NN
cord-023168-cd7adns8	153	23	and	and	CC
cord-023168-cd7adns8	153	24	chronic	chronic	JJ
cord-023168-cd7adns8	153	25	respiratory	respiratory	JJ
cord-023168-cd7adns8	153	26	disease	disease	NN
cord-023168-cd7adns8	153	27	,	,	,
cord-023168-cd7adns8	153	28	and	and	CC
cord-023168-cd7adns8	153	29	cancer	cancer	NN
cord-023168-cd7adns8	153	30	and	and	CC
cord-023168-cd7adns8	153	31	related	relate	VBN
cord-023168-cd7adns8	153	32	complications	complication	NNS
cord-023168-cd7adns8	153	33	are	be	VBP
cord-023168-cd7adns8	153	34	increasing	increase	VBG
cord-023168-cd7adns8	153	35	as	as	IN
cord-023168-cd7adns8	153	36	causes	cause	NNS
cord-023168-cd7adns8	153	37	partly	partly	RB
cord-023168-cd7adns8	153	38	due	due	JJ
cord-023168-cd7adns8	153	39	to	to	IN
cord-023168-cd7adns8	153	40	lifestyle	lifestyle	NN
cord-023168-cd7adns8	153	41	changes	change	NNS
cord-023168-cd7adns8	153	42	.	.	.
cord-023168-cd7adns8	154	1	the	the	DT
cord-023168-cd7adns8	154	2	body	body	NN
cord-023168-cd7adns8	154	3	to	to	TO
cord-023168-cd7adns8	154	4	compensate	compensate	VB
cord-023168-cd7adns8	154	5	for	for	IN
cord-023168-cd7adns8	154	6	the	the	DT
cord-023168-cd7adns8	154	7	drop	drop	NN
cord-023168-cd7adns8	154	8	in	in	IN
cord-023168-cd7adns8	154	9	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	154	10	content	content	NN
cord-023168-cd7adns8	154	11	.	.	.
cord-023168-cd7adns8	155	1	For	for	IN
cord-023168-cd7adns8	155	2	this	this	DT
cord-023168-cd7adns8	155	3	reason	reason	NN
cord-023168-cd7adns8	155	4	the	the	DT
cord-023168-cd7adns8	155	5	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	155	6	level	level	NN
cord-023168-cd7adns8	155	7	can	can	MD
cord-023168-cd7adns8	155	8	drop	drop	VB
cord-023168-cd7adns8	155	9	to	to	IN
cord-023168-cd7adns8	155	10	extremely	extremely	RB
cord-023168-cd7adns8	155	11	low	low	JJ
cord-023168-cd7adns8	155	12	levels	level	NNS
cord-023168-cd7adns8	155	13	before	before	IN
cord-023168-cd7adns8	155	14	symptoms	symptom	NNS
cord-023168-cd7adns8	155	15	develop	develop	VBP
cord-023168-cd7adns8	155	16	.	.	.
cord-023168-cd7adns8	156	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	156	2	presents	present	VBZ
cord-023168-cd7adns8	156	3	with	with	IN
cord-023168-cd7adns8	156	4	symptoms	symptom	NNS
cord-023168-cd7adns8	156	5	such	such	JJ
cord-023168-cd7adns8	156	6	as	as	IN
cord-023168-cd7adns8	156	7	exertional	exertional	JJ
cord-023168-cd7adns8	156	8	breathlessness	breathlessness	NN
cord-023168-cd7adns8	156	9	,	,	,
cord-023168-cd7adns8	156	10	palpitations	palpitation	NNS
cord-023168-cd7adns8	156	11	and	and	CC
cord-023168-cd7adns8	156	12	in	in	IN
cord-023168-cd7adns8	156	13	some	some	DT
cord-023168-cd7adns8	156	14	cases	case	NNS
cord-023168-cd7adns8	156	15	,	,	,
cord-023168-cd7adns8	156	16	syncopal	syncopal	JJ
cord-023168-cd7adns8	156	17	attacks	attack	NNS
cord-023168-cd7adns8	156	18	.	.	.
cord-023168-cd7adns8	157	1	Patients	patient	NNS
cord-023168-cd7adns8	157	2	with	with	IN
cord-023168-cd7adns8	157	3	chronic	chronic	JJ
cord-023168-cd7adns8	157	4	anaemia	anaemia	NN
cord-023168-cd7adns8	157	5	may	may	MD
cord-023168-cd7adns8	157	6	also	also	RB
cord-023168-cd7adns8	157	7	have	have	VB
cord-023168-cd7adns8	157	8	a	a	DT
cord-023168-cd7adns8	157	9	multitude	multitude	NN
cord-023168-cd7adns8	157	10	of	of	IN
cord-023168-cd7adns8	157	11	nonspecific	nonspecific	JJ
cord-023168-cd7adns8	157	12	symptoms	symptom	NNS
cord-023168-cd7adns8	157	13	including	include	VBG
cord-023168-cd7adns8	157	14	poor	poor	JJ
cord-023168-cd7adns8	157	15	concentration	concentration	NN
cord-023168-cd7adns8	157	16	,	,	,
cord-023168-cd7adns8	157	17	decreased	decrease	VBD
cord-023168-cd7adns8	157	18	work	work	NN
cord-023168-cd7adns8	157	19	performance	performance	NN
cord-023168-cd7adns8	157	20	and	and	CC
cord-023168-cd7adns8	157	21	easy	easy	JJ
cord-023168-cd7adns8	157	22	exhaustion	exhaustion	NN
cord-023168-cd7adns8	157	23	(	(	-LRB-
cord-023168-cd7adns8	157	24	Table	table	NN
cord-023168-cd7adns8	157	25	65	65	CD
cord-023168-cd7adns8	157	26	.	.	.
cord-023168-cd7adns8	157	27	3	3	CD
cord-023168-cd7adns8	157	28	)	)	-RRB-
cord-023168-cd7adns8	157	29	.	.	.
cord-023168-cd7adns8	158	1	A	a	DT
cord-023168-cd7adns8	158	2	thorough	thorough	JJ
cord-023168-cd7adns8	158	3	history	history	NN
cord-023168-cd7adns8	158	4	and	and	CC
cord-023168-cd7adns8	158	5	clinical	clinical	JJ
cord-023168-cd7adns8	158	6	examination	examination	NN
cord-023168-cd7adns8	158	7	may	may	MD
cord-023168-cd7adns8	158	8	provide	provide	VB
cord-023168-cd7adns8	158	9	clues	clue	NNS
cord-023168-cd7adns8	158	10	about	about	IN
cord-023168-cd7adns8	158	11	the	the	DT
cord-023168-cd7adns8	158	12	cause	cause	NN
cord-023168-cd7adns8	158	13	of	of	IN
cord-023168-cd7adns8	158	14	anaemia	anaemia	NN
cord-023168-cd7adns8	158	15	but	but	CC
cord-023168-cd7adns8	158	16	further	further	JJ
cord-023168-cd7adns8	158	17	investigations	investigation	NNS
cord-023168-cd7adns8	158	18	are	be	VBP
cord-023168-cd7adns8	158	19	often	often	RB
cord-023168-cd7adns8	158	20	necessary	necessary	JJ
cord-023168-cd7adns8	158	21	to	to	TO
cord-023168-cd7adns8	158	22	confirm	confirm	VB
cord-023168-cd7adns8	158	23	the	the	DT
cord-023168-cd7adns8	158	24	diagnosis	diagnosis	NN
cord-023168-cd7adns8	158	25	and	and	CC
cord-023168-cd7adns8	158	26	guide	guide	NN
cord-023168-cd7adns8	158	27	treatment	treatment	NN
cord-023168-cd7adns8	158	28	.	.	.
cord-023168-cd7adns8	159	1	However	however	RB
cord-023168-cd7adns8	159	2	,	,	,
cord-023168-cd7adns8	159	3	in	in	IN
cord-023168-cd7adns8	159	4	many	many	JJ
cord-023168-cd7adns8	159	5	resource	resource	NN
cord-023168-cd7adns8	159	6	-	-	HYPH
cord-023168-cd7adns8	159	7	poor	poor	JJ
cord-023168-cd7adns8	159	8	settings	setting	NNS
cord-023168-cd7adns8	159	9	,	,	,
cord-023168-cd7adns8	159	10	access	access	NN
cord-023168-cd7adns8	159	11	to	to	IN
cord-023168-cd7adns8	159	12	routine	routine	JJ
cord-023168-cd7adns8	159	13	biochemical	biochemical	JJ
cord-023168-cd7adns8	159	14	and	and	CC
cord-023168-cd7adns8	159	15	haematological	haematological	JJ
cord-023168-cd7adns8	159	16	testing	testing	NN
cord-023168-cd7adns8	159	17	is	be	VBZ
cord-023168-cd7adns8	159	18	scarce	scarce	JJ
cord-023168-cd7adns8	159	19	,	,	,
cord-023168-cd7adns8	159	20	so	so	RB
cord-023168-cd7adns8	159	21	much	much	JJ
cord-023168-cd7adns8	159	22	reliance	reliance	NN
cord-023168-cd7adns8	159	23	is	be	VBZ
cord-023168-cd7adns8	159	24	placed	place	VBN
cord-023168-cd7adns8	159	25	on	on	IN
cord-023168-cd7adns8	159	26	clinical	clinical	JJ
cord-023168-cd7adns8	159	27	examination	examination	NN
cord-023168-cd7adns8	159	28	.	.	.
cord-023168-cd7adns8	160	1	The	the	DT
cord-023168-cd7adns8	160	2	international	international	JJ
cord-023168-cd7adns8	160	3	guidelines	guideline	NNS
cord-023168-cd7adns8	160	4	for	for	IN
cord-023168-cd7adns8	160	5	the	the	DT
cord-023168-cd7adns8	160	6	Integrated	Integrated	NNP
cord-023168-cd7adns8	160	7	Management	Management	NNP
cord-023168-cd7adns8	160	8	of	of	IN
cord-023168-cd7adns8	160	9	Childhood	Childhood	NNP
cord-023168-cd7adns8	160	10	Illness	Illness	NNP
cord-023168-cd7adns8	160	11	recommend	recommend	VBP
cord-023168-cd7adns8	160	12	that	that	IN
cord-023168-cd7adns8	160	13	a	a	DT
cord-023168-cd7adns8	160	14	diagnosis	diagnosis	NN
cord-023168-cd7adns8	160	15	of	of	IN
cord-023168-cd7adns8	160	16	anaemia	anaemia	NN
cord-023168-cd7adns8	160	17	in	in	IN
cord-023168-cd7adns8	160	18	sick	sick	JJ
cord-023168-cd7adns8	160	19	children	child	NNS
cord-023168-cd7adns8	160	20	is	be	VBZ
cord-023168-cd7adns8	160	21	based	base	VBN
cord-023168-cd7adns8	160	22	on	on	IN
cord-023168-cd7adns8	160	23	the	the	DT
cord-023168-cd7adns8	160	24	assessment	assessment	NN
cord-023168-cd7adns8	160	25	of	of	IN
cord-023168-cd7adns8	160	26	palmar	palmar	NN
cord-023168-cd7adns8	160	27	pallor	pallor	NN
cord-023168-cd7adns8	160	28	.	.	.
cord-023168-cd7adns8	161	1	For	for	IN
cord-023168-cd7adns8	161	2	pregnant	pregnant	JJ
cord-023168-cd7adns8	161	3	women	woman	NNS
cord-023168-cd7adns8	161	4	,	,	,
cord-023168-cd7adns8	161	5	symptoms	symptom	NNS
cord-023168-cd7adns8	161	6	of	of	IN
cord-023168-cd7adns8	161	7	fatigue	fatigue	NN
cord-023168-cd7adns8	161	8	and	and	CC
cord-023168-cd7adns8	161	9	dyspnoea	dyspnoea	NNS
cord-023168-cd7adns8	161	10	,	,	,
cord-023168-cd7adns8	161	11	combined	combine	VBN
cord-023168-cd7adns8	161	12	with	with	IN
cord-023168-cd7adns8	161	13	signs	sign	NNS
cord-023168-cd7adns8	161	14	of	of	IN
cord-023168-cd7adns8	161	15	conjunctival	conjunctival	NN
cord-023168-cd7adns8	161	16	and	and	CC
cord-023168-cd7adns8	161	17	palmar	palmar	NN
cord-023168-cd7adns8	161	18	pallor	pallor	NN
cord-023168-cd7adns8	161	19	,	,	,
cord-023168-cd7adns8	161	20	and	and	CC
cord-023168-cd7adns8	161	21	increased	increase	VBN
cord-023168-cd7adns8	161	22	respiratory	respiratory	JJ
cord-023168-cd7adns8	161	23	rate	rate	NN
cord-023168-cd7adns8	161	24	suggest	suggest	VBP
cord-023168-cd7adns8	161	25	anaemia	anaemia	NN
cord-023168-cd7adns8	161	26	.	.	.
cord-023168-cd7adns8	162	1	However	however	RB
cord-023168-cd7adns8	162	2	,	,	,
cord-023168-cd7adns8	162	3	making	make	VBG
cord-023168-cd7adns8	162	4	a	a	DT
cord-023168-cd7adns8	162	5	diagnosis	diagnosis	NN
cord-023168-cd7adns8	162	6	of	of	IN
cord-023168-cd7adns8	162	7	anaemia	anaemia	NN
cord-023168-cd7adns8	162	8	based	base	VBN
cord-023168-cd7adns8	162	9	on	on	IN
cord-023168-cd7adns8	162	10	clinical	clinical	JJ
cord-023168-cd7adns8	162	11	assessment	assessment	NN
cord-023168-cd7adns8	162	12	alone	alone	RB
cord-023168-cd7adns8	162	13	is	be	VBZ
cord-023168-cd7adns8	162	14	unreliable	unreliable	JJ
cord-023168-cd7adns8	162	15	unless	unless	IN
cord-023168-cd7adns8	162	16	the	the	DT
cord-023168-cd7adns8	162	17	anaemia	anaemia	NN
cord-023168-cd7adns8	162	18	is	be	VBZ
cord-023168-cd7adns8	162	19	severe	severe	JJ
cord-023168-cd7adns8	162	20	.	.	.
cord-023168-cd7adns8	163	1	12	12	CD
cord-023168-cd7adns8	163	2	No	no	DT
cord-023168-cd7adns8	163	3	specific	specific	JJ
cord-023168-cd7adns8	163	4	anatomical	anatomical	JJ
cord-023168-cd7adns8	163	5	site	site	NN
cord-023168-cd7adns8	163	6	is	be	VBZ
cord-023168-cd7adns8	163	7	particularly	particularly	RB
cord-023168-cd7adns8	163	8	accurate	accurate	JJ
cord-023168-cd7adns8	163	9	for	for	IN
cord-023168-cd7adns8	163	10	the	the	DT
cord-023168-cd7adns8	163	11	prediction	prediction	NN
cord-023168-cd7adns8	163	12	of	of	IN
cord-023168-cd7adns8	163	13	anaemia	anaemia	NN
cord-023168-cd7adns8	163	14	11	11	CD
cord-023168-cd7adns8	163	15	though	though	IN
cord-023168-cd7adns8	163	16	sensitivity	sensitivity	NN
cord-023168-cd7adns8	163	17	may	may	MD
cord-023168-cd7adns8	163	18	be	be	VB
cord-023168-cd7adns8	163	19	increased	increase	VBN
cord-023168-cd7adns8	163	20	by	by	IN
cord-023168-cd7adns8	163	21	using	use	VBG
cord-023168-cd7adns8	163	22	multiple	multiple	JJ
cord-023168-cd7adns8	163	23	sites	site	NNS
cord-023168-cd7adns8	163	24	.	.	.
cord-023168-cd7adns8	164	1	12	12	CD
cord-023168-cd7adns8	164	2	 	 	_SP
cord-023168-cd7adns8	165	1	Most	Most	JJS
cord-023168-cd7adns8	165	2	central	central	JJ
cord-023168-cd7adns8	165	3	laboratories	laboratory	NNS
cord-023168-cd7adns8	165	4	in	in	IN
cord-023168-cd7adns8	165	5	low	low	JJ
cord-023168-cd7adns8	165	6	-	-	HYPH
cord-023168-cd7adns8	165	7	income	income	NN
cord-023168-cd7adns8	165	8	countries	country	NNS
cord-023168-cd7adns8	165	9	have	have	VBP
cord-023168-cd7adns8	165	10	automated	automate	VBN
cord-023168-cd7adns8	165	11	haematology	haematology	NN
cord-023168-cd7adns8	165	12	analysers	analyser	NNS
cord-023168-cd7adns8	165	13	and	and	CC
cord-023168-cd7adns8	165	14	several	several	JJ
cord-023168-cd7adns8	165	15	manual	manual	JJ
cord-023168-cd7adns8	165	16	methods	method	NNS
cord-023168-cd7adns8	165	17	exist	exist	VBP
cord-023168-cd7adns8	165	18	for	for	IN
cord-023168-cd7adns8	165	19	assessment	assessment	NN
cord-023168-cd7adns8	165	20	of	of	IN
cord-023168-cd7adns8	165	21	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	165	22	concentration	concentration	NN
cord-023168-cd7adns8	165	23	,	,	,
cord-023168-cd7adns8	165	24	which	which	WDT
cord-023168-cd7adns8	165	25	are	be	VBP
cord-023168-cd7adns8	165	26	suitable	suitable	JJ
cord-023168-cd7adns8	165	27	for	for	IN
cord-023168-cd7adns8	165	28	rural	rural	JJ
cord-023168-cd7adns8	165	29	areas	area	NNS
cord-023168-cd7adns8	165	30	where	where	WRB
cord-023168-cd7adns8	165	31	there	there	EX
cord-023168-cd7adns8	165	32	is	be	VBZ
cord-023168-cd7adns8	165	33	no	no	DT
cord-023168-cd7adns8	165	34	mains	main	NNS
cord-023168-cd7adns8	165	35	electricity	electricity	NN
cord-023168-cd7adns8	166	1	(	(	-LRB-
cord-023168-cd7adns8	166	2	e.g.	e.g.	DT
cord-023168-cd7adns8	166	3	Haemoglobin	Haemoglobin	NNP
cord-023168-cd7adns8	166	4	Colour	Colour	NNP
cord-023168-cd7adns8	166	5	Scale	Scale	NNP
cord-023168-cd7adns8	166	6	;	;	:
cord-023168-cd7adns8	166	7	HemoCue	HemoCue	NNP
cord-023168-cd7adns8	166	8	technique	technique	NN
cord-023168-cd7adns8	166	9	)	)	-RRB-
cord-023168-cd7adns8	166	10	.	.	.
cord-023168-cd7adns8	167	1	[	[	-LRB-
cord-023168-cd7adns8	167	2	13	13	CD
cord-023168-cd7adns8	167	3	]	]	-RRB-
cord-023168-cd7adns8	167	4	[	[	-LRB-
cord-023168-cd7adns8	167	5	14	14	CD
cord-023168-cd7adns8	167	6	]	]	-RRB-
cord-023168-cd7adns8	167	7	[	[	-LRB-
cord-023168-cd7adns8	167	8	15	15	CD
cord-023168-cd7adns8	167	9	]	]	-RRB-
cord-023168-cd7adns8	167	10	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	167	11	Colour	colour	NN
cord-023168-cd7adns8	167	12	Scale	Scale	NNP
cord-023168-cd7adns8	167	13	16	16	CD
cord-023168-cd7adns8	167	14	Principle	Principle	NNP
cord-023168-cd7adns8	167	15	.	.	.
cord-023168-cd7adns8	168	1	The	the	DT
cord-023168-cd7adns8	168	2	colour	colour	NN
cord-023168-cd7adns8	168	3	of	of	IN
cord-023168-cd7adns8	168	4	a	a	DT
cord-023168-cd7adns8	168	5	finger	finger	NN
cord-023168-cd7adns8	168	6	-	-	HYPH
cord-023168-cd7adns8	168	7	prick	prick	NN
cord-023168-cd7adns8	168	8	blood	blood	NN
cord-023168-cd7adns8	168	9	sample	sample	NN
cord-023168-cd7adns8	168	10	,	,	,
cord-023168-cd7adns8	168	11	soaked	soak	VBN
cord-023168-cd7adns8	168	12	into	into	IN
cord-023168-cd7adns8	168	13	special	special	JJ
cord-023168-cd7adns8	168	14	chromatography	chromatography	NN
cord-023168-cd7adns8	168	15	paper	paper	NN
cord-023168-cd7adns8	168	16	,	,	,
cord-023168-cd7adns8	168	17	is	be	VBZ
cord-023168-cd7adns8	168	18	compared	compare	VBN
cord-023168-cd7adns8	168	19	with	with	IN
cord-023168-cd7adns8	168	20	The	the	DT
cord-023168-cd7adns8	168	21	clinical	clinical	JJ
cord-023168-cd7adns8	168	22	symptoms	symptom	NNS
cord-023168-cd7adns8	168	23	and	and	CC
cord-023168-cd7adns8	168	24	signs	sign	NNS
cord-023168-cd7adns8	168	25	of	of	IN
cord-023168-cd7adns8	168	26	anaemia	anaemia	NN
cord-023168-cd7adns8	168	27	vary	vary	VBP
cord-023168-cd7adns8	168	28	and	and	CC
cord-023168-cd7adns8	168	29	depend	depend	VB
cord-023168-cd7adns8	168	30	on	on	IN
cord-023168-cd7adns8	168	31	the	the	DT
cord-023168-cd7adns8	168	32	cause	cause	NN
cord-023168-cd7adns8	168	33	and	and	CC
cord-023168-cd7adns8	168	34	the	the	DT
cord-023168-cd7adns8	168	35	speed	speed	NN
cord-023168-cd7adns8	168	36	of	of	IN
cord-023168-cd7adns8	168	37	onset	onset	NN
cord-023168-cd7adns8	168	38	.	.	.
cord-023168-cd7adns8	169	1	A	a	DT
cord-023168-cd7adns8	169	2	rapid	rapid	JJ
cord-023168-cd7adns8	169	3	drop	drop	NN
cord-023168-cd7adns8	169	4	in	in	IN
cord-023168-cd7adns8	169	5	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	169	6	is	be	VBZ
cord-023168-cd7adns8	169	7	much	much	RB
cord-023168-cd7adns8	169	8	more	more	RBR
cord-023168-cd7adns8	169	9	likely	likely	JJ
cord-023168-cd7adns8	169	10	to	to	TO
cord-023168-cd7adns8	169	11	cause	cause	VB
cord-023168-cd7adns8	169	12	symptoms	symptom	NNS
cord-023168-cd7adns8	169	13	of	of	IN
cord-023168-cd7adns8	169	14	anaemia	anaemia	NN
cord-023168-cd7adns8	169	15	than	than	IN
cord-023168-cd7adns8	169	16	chronic	chronic	JJ
cord-023168-cd7adns8	169	17	anaemia	anaemia	NN
cord-023168-cd7adns8	169	18	.	.	.
cord-023168-cd7adns8	170	1	Slowly	slowly	RB
cord-023168-cd7adns8	170	2	developing	develop	VBG
cord-023168-cd7adns8	170	3	anaemia	anaemia	NN
cord-023168-cd7adns8	170	4	allows	allow	VBZ
cord-023168-cd7adns8	170	5	time	time	NN
cord-023168-cd7adns8	170	6	for	for	IN
cord-023168-cd7adns8	170	7	 	 	_SP
cord-023168-cd7adns8	171	1	In	in	IN
cord-023168-cd7adns8	171	2	many	many	JJ
cord-023168-cd7adns8	171	3	cases	case	NNS
cord-023168-cd7adns8	171	4	,	,	,
cord-023168-cd7adns8	171	5	there	there	EX
cord-023168-cd7adns8	171	6	will	will	MD
cord-023168-cd7adns8	171	7	be	be	VB
cord-023168-cd7adns8	171	8	more	more	JJR
cord-023168-cd7adns8	171	9	than	than	IN
cord-023168-cd7adns8	171	10	one	one	CD
cord-023168-cd7adns8	171	11	of	of	IN
cord-023168-cd7adns8	171	12	these	these	DT
cord-023168-cd7adns8	171	13	conditions	condition	NNS
cord-023168-cd7adns8	171	14	coexisting	coexist	VBG
cord-023168-cd7adns8	171	15	in	in	IN
cord-023168-cd7adns8	171	16	the	the	DT
cord-023168-cd7adns8	171	17	same	same	JJ
cord-023168-cd7adns8	171	18	individual	individual	NN
cord-023168-cd7adns8	171	19	.	.	.
cord-023168-cd7adns8	172	1	An	an	DT
cord-023168-cd7adns8	172	2	adequate	adequate	JJ
cord-023168-cd7adns8	172	3	response	response	NN
cord-023168-cd7adns8	172	4	to	to	IN
cord-023168-cd7adns8	172	5	the	the	DT
cord-023168-cd7adns8	172	6	treatment	treatment	NN
cord-023168-cd7adns8	172	7	of	of	IN
cord-023168-cd7adns8	172	8	anaemia	anaemia	NN
cord-023168-cd7adns8	172	9	requires	require	VBZ
cord-023168-cd7adns8	172	10	management	management	NN
cord-023168-cd7adns8	172	11	of	of	IN
cord-023168-cd7adns8	172	12	ALL	all	PDT
cord-023168-cd7adns8	172	13	the	the	DT
cord-023168-cd7adns8	172	14	contributory	contributory	JJ
cord-023168-cd7adns8	172	15	factors	factor	NNS
cord-023168-cd7adns8	172	16	.	.	.
cord-023168-cd7adns8	173	1	intrauterine	intrauterine	JJ
cord-023168-cd7adns8	173	2	growth	growth	NN
cord-023168-cd7adns8	173	3	.	.	.
cord-023168-cd7adns8	174	1	Thus	thus	RB
cord-023168-cd7adns8	174	2	,	,	,
cord-023168-cd7adns8	174	3	low	low	JJ
cord-023168-cd7adns8	174	4	birth	birth	NN
cord-023168-cd7adns8	174	5	weight	weight	NN
cord-023168-cd7adns8	174	6	and	and	CC
cord-023168-cd7adns8	174	7	prematurity	prematurity	NN
cord-023168-cd7adns8	174	8	are	be	VBP
cord-023168-cd7adns8	174	9	both	both	DT
cord-023168-cd7adns8	174	10	associated	associate	VBN
cord-023168-cd7adns8	174	11	with	with	IN
cord-023168-cd7adns8	174	12	iron	iron	NN
cord-023168-cd7adns8	174	13	depletion	depletion	NN
cord-023168-cd7adns8	174	14	in	in	IN
cord-023168-cd7adns8	174	15	the	the	DT
cord-023168-cd7adns8	174	16	postnatal	postnatal	JJ
cord-023168-cd7adns8	174	17	period	period	NN
cord-023168-cd7adns8	174	18	.	.	.
cord-023168-cd7adns8	175	1	Several	several	JJ
cord-023168-cd7adns8	175	2	interventions	intervention	NNS
cord-023168-cd7adns8	175	3	have	have	VBP
cord-023168-cd7adns8	175	4	been	be	VBN
cord-023168-cd7adns8	175	5	suggested	suggest	VBN
cord-023168-cd7adns8	175	6	to	to	TO
cord-023168-cd7adns8	175	7	improve	improve	VB
cord-023168-cd7adns8	175	8	infantile	infantile	JJ
cord-023168-cd7adns8	175	9	iron	iron	NN
cord-023168-cd7adns8	175	10	deficiency	deficiency	NN
cord-023168-cd7adns8	175	11	,	,	,
cord-023168-cd7adns8	175	12	including	include	VBG
cord-023168-cd7adns8	175	13	:	:	:
cord-023168-cd7adns8	175	14	[	[	-LRB-
cord-023168-cd7adns8	175	15	17	17	CD
cord-023168-cd7adns8	175	16	]	]	-RRB-
cord-023168-cd7adns8	175	17	[	[	-LRB-
cord-023168-cd7adns8	175	18	18	18	CD
cord-023168-cd7adns8	175	19	]	]	-RRB-
cord-023168-cd7adns8	175	20	[	[	-LRB-
cord-023168-cd7adns8	175	21	19	19	CD
cord-023168-cd7adns8	175	22	]	]	-RRB-
cord-023168-cd7adns8	175	23	•	•	NNP
cord-023168-cd7adns8	175	24	Delayed	delay	VBN
cord-023168-cd7adns8	175	25	cord	cord	NN
cord-023168-cd7adns8	175	26	clamping	clamp	VBG
cord-023168-cd7adns8	175	27	at	at	IN
cord-023168-cd7adns8	175	28	delivery	delivery	NN
cord-023168-cd7adns8	175	29	;	;	:
cord-023168-cd7adns8	175	30	the	the	DT
cord-023168-cd7adns8	175	31	short	short	JJ
cord-023168-cd7adns8	175	32	delay	delay	NN
cord-023168-cd7adns8	175	33	of	of	IN
cord-023168-cd7adns8	175	34	2	2	CD
cord-023168-cd7adns8	175	35	-	-	SYM
cord-023168-cd7adns8	175	36	3	3	CD
cord-023168-cd7adns8	175	37	minutes	minute	NNS
cord-023168-cd7adns8	175	38	allows	allow	VBZ
cord-023168-cd7adns8	175	39	a	a	DT
cord-023168-cd7adns8	175	40	small	small	JJ
cord-023168-cd7adns8	175	41	but	but	CC
cord-023168-cd7adns8	175	42	important	important	JJ
cord-023168-cd7adns8	175	43	amount	amount	NN
cord-023168-cd7adns8	175	44	of	of	IN
cord-023168-cd7adns8	175	45	blood	blood	NN
cord-023168-cd7adns8	175	46	to	to	TO
cord-023168-cd7adns8	175	47	continue	continue	VB
cord-023168-cd7adns8	175	48	to	to	TO
cord-023168-cd7adns8	175	49	flow	flow	VB
cord-023168-cd7adns8	175	50	to	to	IN
cord-023168-cd7adns8	175	51	the	the	DT
cord-023168-cd7adns8	175	52	foetus	foetus	NN
cord-023168-cd7adns8	175	53	from	from	IN
cord-023168-cd7adns8	175	54	the	the	DT
cord-023168-cd7adns8	175	55	placenta	placenta	NN
cord-023168-cd7adns8	176	1	•	•	NNP
cord-023168-cd7adns8	176	2	Improvement	improvement	NN
cord-023168-cd7adns8	176	3	of	of	IN
cord-023168-cd7adns8	176	4	infant	infant	NN
cord-023168-cd7adns8	176	5	feeding	feeding	NN
cord-023168-cd7adns8	176	6	practices	practice	NNS
cord-023168-cd7adns8	177	1	•	•	NNP
cord-023168-cd7adns8	178	1	Prevention	prevention	NN
cord-023168-cd7adns8	178	2	and	and	CC
cord-023168-cd7adns8	178	3	treatment	treatment	NN
cord-023168-cd7adns8	178	4	of	of	IN
cord-023168-cd7adns8	178	5	infectious	infectious	JJ
cord-023168-cd7adns8	178	6	diseases	disease	NNS
cord-023168-cd7adns8	179	1	•	•	NNP
cord-023168-cd7adns8	180	1	Interventions	intervention	NNS
cord-023168-cd7adns8	180	2	to	to	TO
cord-023168-cd7adns8	180	3	prevent	prevent	VB
cord-023168-cd7adns8	180	4	low	low	JJ
cord-023168-cd7adns8	180	5	birth	birth	NN
cord-023168-cd7adns8	180	6	weight	weight	NN
cord-023168-cd7adns8	180	7	,	,	,
cord-023168-cd7adns8	180	8	such	such	JJ
cord-023168-cd7adns8	180	9	as	as	IN
cord-023168-cd7adns8	180	10	maternal	maternal	JJ
cord-023168-cd7adns8	180	11	nutritional	nutritional	JJ
cord-023168-cd7adns8	180	12	supplementation	supplementation	NN
cord-023168-cd7adns8	180	13	,	,	,
cord-023168-cd7adns8	180	14	the	the	DT
cord-023168-cd7adns8	180	15	control	control	NN
cord-023168-cd7adns8	180	16	of	of	IN
cord-023168-cd7adns8	180	17	infections	infection	NNS
cord-023168-cd7adns8	180	18	and	and	CC
cord-023168-cd7adns8	180	19	chronic	chronic	JJ
cord-023168-cd7adns8	180	20	health	health	NN
cord-023168-cd7adns8	180	21	problems	problem	NNS
cord-023168-cd7adns8	180	22	in	in	IN
cord-023168-cd7adns8	180	23	pregnancy	pregnancy	NN
cord-023168-cd7adns8	180	24	.	.	.
cord-023168-cd7adns8	181	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	181	2	in	in	IN
cord-023168-cd7adns8	181	3	young	young	JJ
cord-023168-cd7adns8	181	4	children	child	NNS
cord-023168-cd7adns8	181	5	can	can	MD
cord-023168-cd7adns8	181	6	be	be	VB
cord-023168-cd7adns8	181	7	due	due	JJ
cord-023168-cd7adns8	181	8	to	to	IN
cord-023168-cd7adns8	181	9	increased	increase	VBN
cord-023168-cd7adns8	181	10	nutrition	nutrition	NN
cord-023168-cd7adns8	181	11	requirements	requirement	NNS
cord-023168-cd7adns8	181	12	during	during	IN
cord-023168-cd7adns8	181	13	periods	period	NNS
cord-023168-cd7adns8	181	14	of	of	IN
cord-023168-cd7adns8	181	15	rapid	rapid	JJ
cord-023168-cd7adns8	181	16	growth	growth	NN
cord-023168-cd7adns8	181	17	;	;	:
cord-023168-cd7adns8	181	18	these	these	DT
cord-023168-cd7adns8	181	19	requirements	requirement	NNS
cord-023168-cd7adns8	181	20	may	may	MD
cord-023168-cd7adns8	181	21	be	be	VB
cord-023168-cd7adns8	181	22	up	up	IN
cord-023168-cd7adns8	181	23	to	to	TO
cord-023168-cd7adns8	181	24	10	10	CD
cord-023168-cd7adns8	181	25	times	time	NNS
cord-023168-cd7adns8	181	26	higher	high	JJR
cord-023168-cd7adns8	181	27	per	per	IN
cord-023168-cd7adns8	181	28	kilogram	kilogram	NN
cord-023168-cd7adns8	181	29	of	of	IN
cord-023168-cd7adns8	181	30	body	body	NN
cord-023168-cd7adns8	181	31	weight	weight	NN
cord-023168-cd7adns8	181	32	than	than	IN
cord-023168-cd7adns8	181	33	that	that	DT
cord-023168-cd7adns8	181	34	of	of	IN
cord-023168-cd7adns8	181	35	an	an	DT
cord-023168-cd7adns8	181	36	adult	adult	NN
cord-023168-cd7adns8	181	37	male	male	NN
cord-023168-cd7adns8	181	38	.	.	.
cord-023168-cd7adns8	182	1	In	in	IN
cord-023168-cd7adns8	182	2	addition	addition	NN
cord-023168-cd7adns8	182	3	,	,	,
cord-023168-cd7adns8	182	4	infant	infant	NN
cord-023168-cd7adns8	182	5	and	and	CC
cord-023168-cd7adns8	182	6	toddler	toddler	NN
cord-023168-cd7adns8	182	7	diets	diet	NNS
cord-023168-cd7adns8	182	8	often	often	RB
cord-023168-cd7adns8	182	9	lack	lack	VBP
cord-023168-cd7adns8	182	10	bio	bio	JJ
cord-023168-cd7adns8	182	11	-	-	HYPH
cord-023168-cd7adns8	182	12	available	available	JJ
cord-023168-cd7adns8	182	13	iron	iron	NN
cord-023168-cd7adns8	182	14	.	.	.
cord-023168-cd7adns8	183	1	A	a	DT
cord-023168-cd7adns8	183	2	case	case	NN
cord-023168-cd7adns8	183	3	-	-	HYPH
cord-023168-cd7adns8	183	4	control	control	NN
cord-023168-cd7adns8	183	5	study	study	NN
cord-023168-cd7adns8	183	6	of	of	IN
cord-023168-cd7adns8	183	7	preschool	preschool	NN
cord-023168-cd7adns8	183	8	children	child	NNS
cord-023168-cd7adns8	183	9	in	in	IN
cord-023168-cd7adns8	183	10	Malawi	Malawi	NNP
cord-023168-cd7adns8	183	11	with	with	IN
cord-023168-cd7adns8	183	12	severe	severe	JJ
cord-023168-cd7adns8	183	13	anaemia	anaemia	NN
cord-023168-cd7adns8	183	14	(	(	-LRB-
cord-023168-cd7adns8	183	15	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	183	16	concentration	concentration	NN
cord-023168-cd7adns8	183	17	,	,	,
cord-023168-cd7adns8	183	18	<	<	XX
cord-023168-cd7adns8	183	19	50	50	CD
cord-023168-cd7adns8	183	20	g	g	NN
cord-023168-cd7adns8	183	21	/	/	SYM
cord-023168-cd7adns8	183	22	L	L	NNP
cord-023168-cd7adns8	183	23	)	)	-RRB-
cord-023168-cd7adns8	183	24	identified	identify	VBD
cord-023168-cd7adns8	183	25	bacteraemia	bacteraemia	NN
cord-023168-cd7adns8	183	26	,	,	,
cord-023168-cd7adns8	183	27	malaria	malaria	NN
cord-023168-cd7adns8	183	28	,	,	,
cord-023168-cd7adns8	183	29	hookworm	hookworm	NN
cord-023168-cd7adns8	183	30	,	,	,
cord-023168-cd7adns8	183	31	HIV	HIV	NNP
cord-023168-cd7adns8	183	32	infections	infection	NNS
cord-023168-cd7adns8	183	33	and	and	CC
cord-023168-cd7adns8	183	34	deficiencies	deficiency	NNS
cord-023168-cd7adns8	183	35	of	of	IN
cord-023168-cd7adns8	184	1	vitamins	vitamin	NNS
cord-023168-cd7adns8	184	2	A	A	NNP
cord-023168-cd7adns8	184	3	and	and	CC
cord-023168-cd7adns8	184	4	B	B	NNP
cord-023168-cd7adns8	184	5	12	12	CD
cord-023168-cd7adns8	184	6	as	as	IN
cord-023168-cd7adns8	184	7	the	the	DT
cord-023168-cd7adns8	184	8	commonest	common	JJS
cord-023168-cd7adns8	184	9	causes	cause	NNS
cord-023168-cd7adns8	184	10	of	of	IN
cord-023168-cd7adns8	184	11	anaemia	anaemia	NN
cord-023168-cd7adns8	184	12	.	.	.
cord-023168-cd7adns8	185	1	Lack	lack	NN
cord-023168-cd7adns8	185	2	of	of	IN
cord-023168-cd7adns8	185	3	folate	folate	NN
cord-023168-cd7adns8	185	4	and	and	CC
cord-023168-cd7adns8	185	5	iron	iron	NN
cord-023168-cd7adns8	185	6	were	be	VBD
cord-023168-cd7adns8	185	7	uncommon	uncommon	JJ
cord-023168-cd7adns8	185	8	.	.	.
cord-023168-cd7adns8	186	1	In	in	IN
cord-023168-cd7adns8	186	2	low	low	JJ
cord-023168-cd7adns8	186	3	-	-	HYPH
cord-023168-cd7adns8	186	4	income	income	NN
cord-023168-cd7adns8	186	5	countries	country	NNS
cord-023168-cd7adns8	186	6	multiple	multiple	JJ
cord-023168-cd7adns8	186	7	interdependent	interdependent	JJ
cord-023168-cd7adns8	186	8	causes	cause	NNS
cord-023168-cd7adns8	186	9	of	of	IN
cord-023168-cd7adns8	186	10	anaemia	anaemia	NN
cord-023168-cd7adns8	186	11	often	often	RB
cord-023168-cd7adns8	186	12	operate	operate	VBP
cord-023168-cd7adns8	186	13	in	in	IN
cord-023168-cd7adns8	186	14	one	one	CD
cord-023168-cd7adns8	186	15	individual	individual	NN
cord-023168-cd7adns8	186	16	so	so	RB
cord-023168-cd7adns8	186	17	rectifying	rectify	VBG
cord-023168-cd7adns8	186	18	a	a	DT
cord-023168-cd7adns8	186	19	single	single	JJ
cord-023168-cd7adns8	186	20	factor	factor	NN
cord-023168-cd7adns8	186	21	is	be	VBZ
cord-023168-cd7adns8	186	22	unlikely	unlikely	JJ
cord-023168-cd7adns8	186	23	to	to	TO
cord-023168-cd7adns8	186	24	make	make	VB
cord-023168-cd7adns8	186	25	a	a	DT
cord-023168-cd7adns8	186	26	big	big	JJ
cord-023168-cd7adns8	186	27	impact	impact	NN
cord-023168-cd7adns8	186	28	on	on	IN
cord-023168-cd7adns8	186	29	resolving	resolve	VBG
cord-023168-cd7adns8	186	30	anaemia	anaemia	NN
cord-023168-cd7adns8	186	31	.	.	.
cord-023168-cd7adns8	187	1	Interventions	intervention	NNS
cord-023168-cd7adns8	187	2	which	which	WDT
cord-023168-cd7adns8	187	3	are	be	VBP
cord-023168-cd7adns8	187	4	useful	useful	JJ
cord-023168-cd7adns8	187	5	in	in	IN
cord-023168-cd7adns8	187	6	preventing	prevent	VBG
cord-023168-cd7adns8	187	7	anaemia	anaemia	NN
cord-023168-cd7adns8	187	8	in	in	IN
cord-023168-cd7adns8	187	9	younger	young	JJR
cord-023168-cd7adns8	187	10	children	child	NNS
cord-023168-cd7adns8	187	11	include	include	VBP
cord-023168-cd7adns8	187	12	micronutrient	micronutrient	JJ
cord-023168-cd7adns8	187	13	supplementation	supplementation	NN
cord-023168-cd7adns8	187	14	(	(	-LRB-
cord-023168-cd7adns8	187	15	food	food	NN
cord-023168-cd7adns8	187	16	fortification	fortification	NN
cord-023168-cd7adns8	187	17	)	)	-RRB-
cord-023168-cd7adns8	187	18	,	,	,
cord-023168-cd7adns8	187	19	de	de	NN
cord-023168-cd7adns8	187	20	-	-	JJ
cord-023168-cd7adns8	187	21	worming	worming	JJ
cord-023168-cd7adns8	187	22	,	,	,
cord-023168-cd7adns8	187	23	prevention	prevention	NN
cord-023168-cd7adns8	187	24	and	and	CC
cord-023168-cd7adns8	187	25	treatment	treatment	NN
cord-023168-cd7adns8	187	26	of	of	IN
cord-023168-cd7adns8	187	27	infectious	infectious	JJ
cord-023168-cd7adns8	187	28	diseases	disease	NNS
cord-023168-cd7adns8	187	29	,	,	,
cord-023168-cd7adns8	187	30	school	school	NN
cord-023168-cd7adns8	187	31	nutrition	nutrition	NN
cord-023168-cd7adns8	187	32	programmes	programme	NNS
cord-023168-cd7adns8	187	33	and	and	CC
cord-023168-cd7adns8	187	34	community	community	NN
cord-023168-cd7adns8	187	35	-	-	HYPH
cord-023168-cd7adns8	187	36	based	base	VBN
cord-023168-cd7adns8	187	37	nutrition	nutrition	NN
cord-023168-cd7adns8	187	38	promotion	promotion	NN
cord-023168-cd7adns8	187	39	.	.	.
cord-023168-cd7adns8	188	1	WHO	who	WP
cord-023168-cd7adns8	188	2	defines	define	VBZ
cord-023168-cd7adns8	188	3	anaemia	anaemia	NN
cord-023168-cd7adns8	188	4	of	of	IN
cord-023168-cd7adns8	188	5	pregnancy	pregnancy	NN
cord-023168-cd7adns8	188	6	as	as	IN
cord-023168-cd7adns8	188	7	a	a	DT
cord-023168-cd7adns8	188	8	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	188	9	level	level	NN
cord-023168-cd7adns8	188	10	less	less	JJR
cord-023168-cd7adns8	188	11	than	than	IN
cord-023168-cd7adns8	188	12	110	110	CD
cord-023168-cd7adns8	188	13	g	g	NN
cord-023168-cd7adns8	188	14	/	/	SYM
cord-023168-cd7adns8	188	15	L	L	NNP
cord-023168-cd7adns8	188	16	,	,	,
cord-023168-cd7adns8	188	17	or	or	CC
cord-023168-cd7adns8	188	18	haematocrit	haematocrit	NNP
cord-023168-cd7adns8	188	19	less	less	JJR
cord-023168-cd7adns8	188	20	than	than	IN
cord-023168-cd7adns8	188	21	33	33	CD
cord-023168-cd7adns8	188	22	%	%	NN
cord-023168-cd7adns8	188	23	,	,	,
cord-023168-cd7adns8	188	24	at	at	IN
cord-023168-cd7adns8	188	25	any	any	DT
cord-023168-cd7adns8	188	26	time	time	NN
cord-023168-cd7adns8	188	27	during	during	IN
cord-023168-cd7adns8	188	28	pregnancy	pregnancy	NN
cord-023168-cd7adns8	188	29	.	.	.
cord-023168-cd7adns8	189	1	About	about	RB
cord-023168-cd7adns8	189	2	one	one	CD
cord-023168-cd7adns8	189	3	-	-	HYPH
cord-023168-cd7adns8	189	4	fifth	fifth	NN
cord-023168-cd7adns8	189	5	of	of	IN
cord-023168-cd7adns8	189	6	maternal	maternal	JJ
cord-023168-cd7adns8	189	7	mortality	mortality	NN
cord-023168-cd7adns8	189	8	is	be	VBZ
cord-023168-cd7adns8	189	9	attributable	attributable	JJ
cord-023168-cd7adns8	189	10	to	to	IN
cord-023168-cd7adns8	189	11	anaemia	anaemia	NN
cord-023168-cd7adns8	189	12	in	in	IN
cord-023168-cd7adns8	189	13	pregnancy	pregnancy	NN
cord-023168-cd7adns8	189	14	20	20	CD
cord-023168-cd7adns8	189	15	and	and	CC
cord-023168-cd7adns8	189	16	anaemia	anaemia	NN
cord-023168-cd7adns8	189	17	affects	affect	VBZ
cord-023168-cd7adns8	189	18	nearly	nearly	RB
cord-023168-cd7adns8	189	19	half	half	NN
cord-023168-cd7adns8	189	20	of	of	IN
cord-023168-cd7adns8	189	21	all	all	DT
cord-023168-cd7adns8	189	22	pregnant	pregnant	JJ
cord-023168-cd7adns8	189	23	women	woman	NNS
cord-023168-cd7adns8	189	24	worldwide	worldwide	RB
cord-023168-cd7adns8	189	25	.	.	.
cord-023168-cd7adns8	190	1	Maternal	maternal	JJ
cord-023168-cd7adns8	190	2	anaemia	anaemia	NN
cord-023168-cd7adns8	190	3	is	be	VBZ
cord-023168-cd7adns8	190	4	associated	associate	VBN
cord-023168-cd7adns8	190	5	with	with	IN
cord-023168-cd7adns8	190	6	many	many	JJ
cord-023168-cd7adns8	190	7	factors	factor	NNS
cord-023168-cd7adns8	190	8	that	that	WDT
cord-023168-cd7adns8	190	9	might	may	MD
cord-023168-cd7adns8	190	10	also	also	RB
cord-023168-cd7adns8	190	11	be	be	VB
cord-023168-cd7adns8	190	12	causally	causally	RB
cord-023168-cd7adns8	190	13	associated	associate	VBN
cord-023168-cd7adns8	190	14	with	with	IN
cord-023168-cd7adns8	190	15	mortality	mortality	NN
cord-023168-cd7adns8	190	16	including	include	VBG
cord-023168-cd7adns8	190	17	poverty	poverty	NN
cord-023168-cd7adns8	190	18	,	,	,
cord-023168-cd7adns8	190	19	infections	infection	NNS
cord-023168-cd7adns8	190	20	and	and	CC
cord-023168-cd7adns8	190	21	inadequate	inadequate	JJ
cord-023168-cd7adns8	190	22	health	health	NN
cord-023168-cd7adns8	190	23	-	-	HYPH
cord-023168-cd7adns8	190	24	seeking	seek	VBG
cord-023168-cd7adns8	190	25	behaviour	behaviour	NN
cord-023168-cd7adns8	190	26	.	.	.
cord-023168-cd7adns8	191	1	Globally	globally	RB
cord-023168-cd7adns8	191	2	,	,	,
cord-023168-cd7adns8	191	3	the	the	DT
cord-023168-cd7adns8	191	4	most	most	RBS
cord-023168-cd7adns8	191	5	important	important	JJ
cord-023168-cd7adns8	191	6	cause	cause	NN
cord-023168-cd7adns8	191	7	of	of	IN
cord-023168-cd7adns8	191	8	anaemia	anaemia	NN
cord-023168-cd7adns8	191	9	in	in	IN
cord-023168-cd7adns8	191	10	pregnancy	pregnancy	NN
cord-023168-cd7adns8	191	11	is	be	VBZ
cord-023168-cd7adns8	191	12	iron	iron	NN
cord-023168-cd7adns8	191	13	deficiency	deficiency	NN
cord-023168-cd7adns8	191	14	although	although	IN
cord-023168-cd7adns8	191	15	hookworm	hookworm	NN
cord-023168-cd7adns8	191	16	,	,	,
cord-023168-cd7adns8	191	17	malaria	malaria	NN
cord-023168-cd7adns8	191	18	,	,	,
cord-023168-cd7adns8	191	19	HIV	HIV	NNP
cord-023168-cd7adns8	191	20	infection	infection	NN
cord-023168-cd7adns8	191	21	,	,	,
cord-023168-cd7adns8	191	22	and	and	CC
cord-023168-cd7adns8	191	23	deficiencies	deficiency	NNS
cord-023168-cd7adns8	191	24	in	in	IN
cord-023168-cd7adns8	191	25	folate	folate	NN
cord-023168-cd7adns8	191	26	and	and	CC
cord-023168-cd7adns8	191	27	other	other	JJ
cord-023168-cd7adns8	191	28	micronutrients	micronutrient	NNS
cord-023168-cd7adns8	191	29	may	may	MD
cord-023168-cd7adns8	191	30	contribute	contribute	VB
cord-023168-cd7adns8	191	31	.	.	.
cord-023168-cd7adns8	192	1	Pregnancy	pregnancy	NN
cord-023168-cd7adns8	192	2	-	-	HYPH
cord-023168-cd7adns8	192	3	associated	associate	VBN
cord-023168-cd7adns8	192	4	complications	complication	NNS
cord-023168-cd7adns8	192	5	,	,	,
cord-023168-cd7adns8	192	6	including	include	VBG
cord-023168-cd7adns8	192	7	septicaemia	septicaemia	NN
cord-023168-cd7adns8	192	8	,	,	,
cord-023168-cd7adns8	192	9	pre	pre	JJ
cord-023168-cd7adns8	192	10	-	-	VB
cord-023168-cd7adns8	192	11	eclampsia	eclampsia	JJ
cord-023168-cd7adns8	192	12	and	and	CC
cord-023168-cd7adns8	192	13	other	other	JJ
cord-023168-cd7adns8	192	14	obstetric	obstetric	JJ
cord-023168-cd7adns8	192	15	problems	problem	NNS
cord-023168-cd7adns8	192	16	can	can	MD
cord-023168-cd7adns8	192	17	precipitate	precipitate	VB
cord-023168-cd7adns8	192	18	anaemia	anaemia	NN
cord-023168-cd7adns8	192	19	.	.	.
cord-023168-cd7adns8	193	1	21	21	CD
cord-023168-cd7adns8	194	1	It	-PRON-	PRP
cord-023168-cd7adns8	194	2	is	be	VBZ
cord-023168-cd7adns8	194	3	important	important	JJ
cord-023168-cd7adns8	194	4	to	to	TO
cord-023168-cd7adns8	194	5	note	note	VB
cord-023168-cd7adns8	194	6	that	that	IN
cord-023168-cd7adns8	194	7	a	a	DT
cord-023168-cd7adns8	194	8	diagnosis	diagnosis	NN
cord-023168-cd7adns8	194	9	of	of	IN
cord-023168-cd7adns8	194	10	iron	iron	NN
cord-023168-cd7adns8	194	11	deficiency	deficiency	NN
cord-023168-cd7adns8	194	12	in	in	IN
cord-023168-cd7adns8	194	13	pregnancy	pregnancy	NN
cord-023168-cd7adns8	194	14	which	which	WDT
cord-023168-cd7adns8	194	15	relies	rely	VBZ
cord-023168-cd7adns8	194	16	on	on	IN
cord-023168-cd7adns8	194	17	ferritin	ferritin	NN
cord-023168-cd7adns8	194	18	measurements	measurement	NNS
cord-023168-cd7adns8	194	19	may	may	MD
cord-023168-cd7adns8	194	20	be	be	VB
cord-023168-cd7adns8	194	21	misleading	misleading	JJ
cord-023168-cd7adns8	194	22	because	because	IN
cord-023168-cd7adns8	194	23	of	of	IN
cord-023168-cd7adns8	194	24	high	high	JJ
cord-023168-cd7adns8	194	25	-	-	HYPH
cord-023168-cd7adns8	194	26	quality	quality	NN
cord-023168-cd7adns8	194	27	digital	digital	JJ
cord-023168-cd7adns8	194	28	examples	example	NNS
cord-023168-cd7adns8	194	29	of	of	IN
cord-023168-cd7adns8	194	30	known	know	VBN
cord-023168-cd7adns8	194	31	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	194	32	concentration	concentration	NN
cord-023168-cd7adns8	194	33	.	.	.
cord-023168-cd7adns8	195	1	The	the	DT
cord-023168-cd7adns8	195	2	colours	colour	NNS
cord-023168-cd7adns8	195	3	are	be	VBP
cord-023168-cd7adns8	195	4	represented	represent	VBN
cord-023168-cd7adns8	195	5	in	in	IN
cord-023168-cd7adns8	195	6	20	20	CD
cord-023168-cd7adns8	195	7	g	g	NN
cord-023168-cd7adns8	195	8	/	/	SYM
cord-023168-cd7adns8	195	9	L	L	NNP
cord-023168-cd7adns8	195	10	increments	increment	NNS
cord-023168-cd7adns8	195	11	from	from	IN
cord-023168-cd7adns8	195	12	40	40	CD
cord-023168-cd7adns8	195	13	g	g	NN
cord-023168-cd7adns8	195	14	/	/	SYM
cord-023168-cd7adns8	195	15	L	l	NN
cord-023168-cd7adns8	195	16	to	to	IN
cord-023168-cd7adns8	195	17	140	140	CD
cord-023168-cd7adns8	195	18	g	g	NN
cord-023168-cd7adns8	195	19	/	/	SYM
cord-023168-cd7adns8	195	20	L.	L.	NNP
cord-023168-cd7adns8	196	1	This	this	DT
cord-023168-cd7adns8	196	2	method	method	NN
cord-023168-cd7adns8	196	3	is	be	VBZ
cord-023168-cd7adns8	196	4	inexpensive	inexpensive	JJ
cord-023168-cd7adns8	196	5	,	,	,
cord-023168-cd7adns8	196	6	does	do	VBZ
cord-023168-cd7adns8	196	7	not	not	RB
cord-023168-cd7adns8	196	8	depend	depend	VB
cord-023168-cd7adns8	196	9	on	on	IN
cord-023168-cd7adns8	196	10	skilled	skilled	JJ
cord-023168-cd7adns8	196	11	scientists	scientist	NNS
cord-023168-cd7adns8	196	12	,	,	,
cord-023168-cd7adns8	196	13	is	be	VBZ
cord-023168-cd7adns8	196	14	durable	durable	JJ
cord-023168-cd7adns8	196	15	in	in	IN
cord-023168-cd7adns8	196	16	dusty	dusty	JJ
cord-023168-cd7adns8	196	17	,	,	,
cord-023168-cd7adns8	196	18	hot	hot	JJ
cord-023168-cd7adns8	196	19	,	,	,
cord-023168-cd7adns8	196	20	dry	dry	JJ
cord-023168-cd7adns8	196	21	and	and	CC
cord-023168-cd7adns8	196	22	humid	humid	JJ
cord-023168-cd7adns8	196	23	conditions	condition	NNS
cord-023168-cd7adns8	196	24	and	and	CC
cord-023168-cd7adns8	196	25	is	be	VBZ
cord-023168-cd7adns8	196	26	probably	probably	RB
cord-023168-cd7adns8	196	27	better	well	JJR
cord-023168-cd7adns8	196	28	than	than	IN
cord-023168-cd7adns8	196	29	clinical	clinical	JJ
cord-023168-cd7adns8	196	30	diagnosis	diagnosis	NN
cord-023168-cd7adns8	196	31	for	for	IN
cord-023168-cd7adns8	196	32	detecting	detect	VBG
cord-023168-cd7adns8	196	33	mild	mild	JJ
cord-023168-cd7adns8	196	34	and	and	CC
cord-023168-cd7adns8	196	35	moderate	moderate	JJ
cord-023168-cd7adns8	196	36	degrees	degree	NNS
cord-023168-cd7adns8	196	37	of	of	IN
cord-023168-cd7adns8	196	38	anaemia	anaemia	NN
cord-023168-cd7adns8	196	39	.	.	.
cord-023168-cd7adns8	197	1	The	the	DT
cord-023168-cd7adns8	197	2	disadvantages	disadvantage	NNS
cord-023168-cd7adns8	197	3	are	be	VBP
cord-023168-cd7adns8	197	4	that	that	IN
cord-023168-cd7adns8	197	5	it	-PRON-	PRP
cord-023168-cd7adns8	197	6	requires	require	VBZ
cord-023168-cd7adns8	197	7	specific	specific	JJ
cord-023168-cd7adns8	197	8	chromatography	chromatography	NN
cord-023168-cd7adns8	197	9	paper	paper	NN
cord-023168-cd7adns8	197	10	and	and	CC
cord-023168-cd7adns8	197	11	good	good	JJ
cord-023168-cd7adns8	197	12	natural	natural	JJ
cord-023168-cd7adns8	197	13	light	light	NN
cord-023168-cd7adns8	198	1	and	and	CC
cord-023168-cd7adns8	198	2	it	-PRON-	PRP
cord-023168-cd7adns8	198	3	can	can	MD
cord-023168-cd7adns8	198	4	not	not	RB
cord-023168-cd7adns8	198	5	detect	detect	VB
cord-023168-cd7adns8	198	6	changes	change	NNS
cord-023168-cd7adns8	198	7	in	in	IN
cord-023168-cd7adns8	198	8	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	199	1	less	less	JJR
cord-023168-cd7adns8	199	2	than	than	IN
cord-023168-cd7adns8	199	3	10	10	CD
cord-023168-cd7adns8	199	4	g	g	NN
cord-023168-cd7adns8	199	5	/	/	SYM
cord-023168-cd7adns8	199	6	L.	L.	NNP
cord-023168-cd7adns8	200	1	This	this	DT
cord-023168-cd7adns8	200	2	is	be	VBZ
cord-023168-cd7adns8	200	3	a	a	DT
cord-023168-cd7adns8	200	4	small	small	JJ
cord-023168-cd7adns8	200	5	battery	battery	NN
cord-023168-cd7adns8	200	6	-	-	HYPH
cord-023168-cd7adns8	200	7	or	or	CC
cord-023168-cd7adns8	200	8	mains	main	NNS
cord-023168-cd7adns8	200	9	-	-	HYPH
cord-023168-cd7adns8	200	10	operated	operate	VBN
cord-023168-cd7adns8	200	11	machine	machine	NN
cord-023168-cd7adns8	200	12	,	,	,
cord-023168-cd7adns8	200	13	which	which	WDT
cord-023168-cd7adns8	200	14	uses	use	VBZ
cord-023168-cd7adns8	200	15	a	a	DT
cord-023168-cd7adns8	200	16	drop	drop	NN
cord-023168-cd7adns8	200	17	of	of	IN
cord-023168-cd7adns8	200	18	blood	blood	NN
cord-023168-cd7adns8	200	19	in	in	IN
cord-023168-cd7adns8	200	20	a	a	DT
cord-023168-cd7adns8	200	21	plastic	plastic	JJ
cord-023168-cd7adns8	200	22	cuvette	cuvette	NN
cord-023168-cd7adns8	200	23	to	to	TO
cord-023168-cd7adns8	200	24	produce	produce	VB
cord-023168-cd7adns8	200	25	a	a	DT
cord-023168-cd7adns8	200	26	direct	direct	JJ
cord-023168-cd7adns8	200	27	read	read	NN
cord-023168-cd7adns8	200	28	-	-	HYPH
cord-023168-cd7adns8	200	29	out	out	NN
cord-023168-cd7adns8	200	30	of	of	IN
cord-023168-cd7adns8	200	31	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	200	32	in	in	IN
cord-023168-cd7adns8	200	33	a	a	DT
cord-023168-cd7adns8	200	34	few	few	JJ
cord-023168-cd7adns8	200	35	seconds	second	NNS
cord-023168-cd7adns8	200	36	.	.	.
cord-023168-cd7adns8	201	1	It	-PRON-	PRP
cord-023168-cd7adns8	201	2	is	be	VBZ
cord-023168-cd7adns8	201	3	simple	simple	JJ
cord-023168-cd7adns8	201	4	to	to	TO
cord-023168-cd7adns8	201	5	use	use	VB
cord-023168-cd7adns8	201	6	,	,	,
cord-023168-cd7adns8	201	7	produces	produce	VBZ
cord-023168-cd7adns8	201	8	accurate	accurate	JJ
cord-023168-cd7adns8	201	9	and	and	CC
cord-023168-cd7adns8	201	10	consistent	consistent	JJ
cord-023168-cd7adns8	201	11	results	result	NNS
cord-023168-cd7adns8	201	12	to	to	IN
cord-023168-cd7adns8	201	13	one	one	CD
cord-023168-cd7adns8	201	14	decimal	decimal	JJ
cord-023168-cd7adns8	201	15	place	place	NN
cord-023168-cd7adns8	201	16	and	and	CC
cord-023168-cd7adns8	202	1	it	-PRON-	PRP
cord-023168-cd7adns8	202	2	has	have	VBZ
cord-023168-cd7adns8	202	3	an	an	DT
cord-023168-cd7adns8	202	4	in	in	RB
cord-023168-cd7adns8	202	5	-	-	HYPH
cord-023168-cd7adns8	202	6	built	build	VBN
cord-023168-cd7adns8	202	7	quality	quality	NN
cord-023168-cd7adns8	202	8	-	-	HYPH
cord-023168-cd7adns8	202	9	checking	check	VBG
cord-023168-cd7adns8	202	10	mechanism	mechanism	NN
cord-023168-cd7adns8	202	11	.	.	.
cord-023168-cd7adns8	203	1	The	the	DT
cord-023168-cd7adns8	203	2	HemoCue	HemoCue	NNP
cord-023168-cd7adns8	203	3	Hb-301	Hb-301	NNP
cord-023168-cd7adns8	203	4	has	have	VBZ
cord-023168-cd7adns8	203	5	been	be	VBN
cord-023168-cd7adns8	203	6	specifically	specifically	RB
cord-023168-cd7adns8	203	7	designed	design	VBN
cord-023168-cd7adns8	203	8	for	for	IN
cord-023168-cd7adns8	203	9	tropical	tropical	JJ
cord-023168-cd7adns8	203	10	conditions	condition	NNS
cord-023168-cd7adns8	203	11	and	and	CC
cord-023168-cd7adns8	203	12	operates	operate	VBZ
cord-023168-cd7adns8	203	13	in	in	IN
cord-023168-cd7adns8	203	14	temperatures	temperature	NNS
cord-023168-cd7adns8	203	15	up	up	IN
cord-023168-cd7adns8	203	16	to	to	TO
cord-023168-cd7adns8	203	17	50	50	CD
cord-023168-cd7adns8	203	18	°	°	NN
cord-023168-cd7adns8	203	19	C	c	NN
cord-023168-cd7adns8	203	20	,	,	,
cord-023168-cd7adns8	203	21	in	in	IN
cord-023168-cd7adns8	203	22	dusty	dusty	JJ
cord-023168-cd7adns8	203	23	and	and	CC
cord-023168-cd7adns8	203	24	humid	humid	JJ
cord-023168-cd7adns8	203	25	conditions	condition	NNS
cord-023168-cd7adns8	203	26	.	.	.
cord-023168-cd7adns8	204	1	However	however	RB
cord-023168-cd7adns8	204	2	the	the	DT
cord-023168-cd7adns8	204	3	recurrent	recurrent	JJ
cord-023168-cd7adns8	204	4	costs	cost	NNS
cord-023168-cd7adns8	204	5	associated	associate	VBN
cord-023168-cd7adns8	204	6	with	with	IN
cord-023168-cd7adns8	204	7	disposable	disposable	JJ
cord-023168-cd7adns8	204	8	plastic	plastic	JJ
cord-023168-cd7adns8	204	9	cuvettes	cuvette	NNS
cord-023168-cd7adns8	204	10	mean	mean	VBP
cord-023168-cd7adns8	204	11	there	there	EX
cord-023168-cd7adns8	204	12	is	be	VBZ
cord-023168-cd7adns8	204	13	little	little	JJ
cord-023168-cd7adns8	204	14	opportunity	opportunity	NN
cord-023168-cd7adns8	204	15	for	for	IN
cord-023168-cd7adns8	204	16	cost	cost	NN
cord-023168-cd7adns8	204	17	-	-	HYPH
cord-023168-cd7adns8	204	18	saving	saving	NN
cord-023168-cd7adns8	204	19	with	with	IN
cord-023168-cd7adns8	204	20	high	high	JJ
cord-023168-cd7adns8	204	21	-	-	HYPH
cord-023168-cd7adns8	204	22	volume	volume	NN
cord-023168-cd7adns8	204	23	workloads	workload	NNS
cord-023168-cd7adns8	204	24	.	.	.
cord-023168-cd7adns8	205	1	The	the	DT
cord-023168-cd7adns8	205	2	iron	iron	NN
cord-023168-cd7adns8	205	3	status	status	NN
cord-023168-cd7adns8	205	4	of	of	IN
cord-023168-cd7adns8	205	5	an	an	DT
cord-023168-cd7adns8	205	6	infant	infant	NN
cord-023168-cd7adns8	205	7	is	be	VBZ
cord-023168-cd7adns8	205	8	directly	directly	RB
cord-023168-cd7adns8	205	9	proportional	proportional	JJ
cord-023168-cd7adns8	205	10	to	to	IN
cord-023168-cd7adns8	205	11	its	-PRON-	PRP$
cord-023168-cd7adns8	205	12	body	body	NN
cord-023168-cd7adns8	205	13	mass	mass	NN
cord-023168-cd7adns8	205	14	and	and	CC
cord-023168-cd7adns8	205	15	blood	blood	NN
cord-023168-cd7adns8	205	16	volume	volume	NN
cord-023168-cd7adns8	205	17	,	,	,
cord-023168-cd7adns8	205	18	both	both	DT
cord-023168-cd7adns8	205	19	of	of	IN
cord-023168-cd7adns8	205	20	which	which	WDT
cord-023168-cd7adns8	205	21	are	be	VBP
cord-023168-cd7adns8	205	22	reflections	reflection	NNS
cord-023168-cd7adns8	205	23	of	of	IN
cord-023168-cd7adns8	205	24	The	the	DT
cord-023168-cd7adns8	205	25	major	major	JJ
cord-023168-cd7adns8	205	26	cause	cause	NN
cord-023168-cd7adns8	205	27	of	of	IN
cord-023168-cd7adns8	205	28	anaemia	anaemia	NN
cord-023168-cd7adns8	205	29	in	in	IN
cord-023168-cd7adns8	205	30	most	most	JJS
cord-023168-cd7adns8	205	31	of	of	IN
cord-023168-cd7adns8	205	32	these	these	DT
cord-023168-cd7adns8	205	33	cases	case	NNS
cord-023168-cd7adns8	205	34	is	be	VBZ
cord-023168-cd7adns8	205	35	iron	iron	NN
cord-023168-cd7adns8	205	36	deficiency	deficiency	NN
cord-023168-cd7adns8	205	37	.	.	.
cord-023168-cd7adns8	206	1	Some	some	DT
cord-023168-cd7adns8	206	2	of	of	IN
cord-023168-cd7adns8	206	3	the	the	DT
cord-023168-cd7adns8	206	4	effects	effect	NNS
cord-023168-cd7adns8	206	5	have	have	VBP
cord-023168-cd7adns8	206	6	been	be	VBN
cord-023168-cd7adns8	206	7	described	describe	VBN
cord-023168-cd7adns8	206	8	in	in	IN
cord-023168-cd7adns8	206	9	individuals	individual	NNS
cord-023168-cd7adns8	206	10	with	with	IN
cord-023168-cd7adns8	206	11	iron	iron	NN
cord-023168-cd7adns8	206	12	deficiency	deficiency	NN
cord-023168-cd7adns8	206	13	without	without	IN
cord-023168-cd7adns8	206	14	obvious	obvious	JJ
cord-023168-cd7adns8	206	15	features	feature	NNS
cord-023168-cd7adns8	206	16	of	of	IN
cord-023168-cd7adns8	206	17	anaemia	anaemia	NN
cord-023168-cd7adns8	206	18	.	.	.
cord-023168-cd7adns8	207	1	There	there	EX
cord-023168-cd7adns8	207	2	are	be	VBP
cord-023168-cd7adns8	207	3	three	three	CD
cord-023168-cd7adns8	207	4	intervention	intervention	NN
cord-023168-cd7adns8	207	5	strategies	strategy	NNS
cord-023168-cd7adns8	207	6	recommended	recommend	VBN
cord-023168-cd7adns8	207	7	by	by	IN
cord-023168-cd7adns8	207	8	WHO	who	WP
cord-023168-cd7adns8	207	9	to	to	TO
cord-023168-cd7adns8	207	10	prevent	prevent	VB
cord-023168-cd7adns8	207	11	anaemia	anaemia	NN
cord-023168-cd7adns8	207	12	in	in	IN
cord-023168-cd7adns8	207	13	pregnancy	pregnancy	NN
cord-023168-cd7adns8	207	14	:	:	:
cord-023168-cd7adns8	207	15	1	1	CD
cord-023168-cd7adns8	207	16	.	.	.
cord-023168-cd7adns8	208	1	Weekly	weekly	JJ
cord-023168-cd7adns8	208	2	iron	iron	NN
cord-023168-cd7adns8	208	3	and	and	CC
cord-023168-cd7adns8	208	4	folic	folic	JJ
cord-023168-cd7adns8	208	5	acid	acid	JJ
cord-023168-cd7adns8	208	6	supplementation	supplementation	NN
cord-023168-cd7adns8	208	7	in	in	IN
cord-023168-cd7adns8	208	8	women	woman	NNS
cord-023168-cd7adns8	208	9	of	of	IN
cord-023168-cd7adns8	208	10	reproductive	reproductive	JJ
cord-023168-cd7adns8	208	11	age	age	NN
cord-023168-cd7adns8	208	12	22	22	CD
cord-023168-cd7adns8	208	13	2	2	CD
cord-023168-cd7adns8	208	14	.	.	.
cord-023168-cd7adns8	209	1	Daily	daily	JJ
cord-023168-cd7adns8	209	2	iron	iron	NN
cord-023168-cd7adns8	209	3	and	and	CC
cord-023168-cd7adns8	209	4	folic	folic	JJ
cord-023168-cd7adns8	209	5	acid	acid	JJ
cord-023168-cd7adns8	209	6	supplementation	supplementation	NN
cord-023168-cd7adns8	209	7	during	during	IN
cord-023168-cd7adns8	209	8	pregnancy	pregnancy	NN
cord-023168-cd7adns8	209	9	3	3	CD
cord-023168-cd7adns8	209	10	.	.	.
cord-023168-cd7adns8	210	1	Presumptive	presumptive	JJ
cord-023168-cd7adns8	210	2	treatment	treatment	NN
cord-023168-cd7adns8	210	3	of	of	IN
cord-023168-cd7adns8	210	4	hookworm	hookworm	NN
cord-023168-cd7adns8	210	5	infection	infection	NN
cord-023168-cd7adns8	210	6	during	during	IN
cord-023168-cd7adns8	210	7	pregnancy	pregnancy	NN
cord-023168-cd7adns8	210	8	in	in	IN
cord-023168-cd7adns8	210	9	areas	area	NNS
cord-023168-cd7adns8	210	10	where	where	WRB
cord-023168-cd7adns8	210	11	hookworm	hookworm	NN
cord-023168-cd7adns8	210	12	infection	infection	NN
cord-023168-cd7adns8	210	13	is	be	VBZ
cord-023168-cd7adns8	210	14	known	know	VBN
cord-023168-cd7adns8	210	15	to	to	TO
cord-023168-cd7adns8	210	16	be	be	VB
cord-023168-cd7adns8	210	17	endemic	endemic	JJ
cord-023168-cd7adns8	210	18	.	.	.
cord-023168-cd7adns8	211	1	23	23	CD
cord-023168-cd7adns8	212	1	Several	several	JJ
cord-023168-cd7adns8	212	2	factors	factor	NNS
cord-023168-cd7adns8	212	3	may	may	MD
cord-023168-cd7adns8	212	4	interfere	interfere	VB
cord-023168-cd7adns8	212	5	with	with	IN
cord-023168-cd7adns8	212	6	the	the	DT
cord-023168-cd7adns8	212	7	efficacy	efficacy	NN
cord-023168-cd7adns8	212	8	of	of	IN
cord-023168-cd7adns8	212	9	these	these	DT
cord-023168-cd7adns8	212	10	interventions	intervention	NNS
cord-023168-cd7adns8	212	11	.	.	.
cord-023168-cd7adns8	213	1	Under	under	IN
cord-023168-cd7adns8	213	2	-	-	HYPH
cord-023168-cd7adns8	213	3	participation	participation	NN
cord-023168-cd7adns8	213	4	in	in	IN
cord-023168-cd7adns8	213	5	antenatal	antenatal	JJ
cord-023168-cd7adns8	213	6	care	care	NN
cord-023168-cd7adns8	213	7	may	may	MD
cord-023168-cd7adns8	213	8	be	be	VB
cord-023168-cd7adns8	213	9	common	common	JJ
cord-023168-cd7adns8	213	10	due	due	IN
cord-023168-cd7adns8	213	11	to	to	IN
cord-023168-cd7adns8	213	12	factors	factor	NNS
cord-023168-cd7adns8	213	13	such	such	JJ
cord-023168-cd7adns8	213	14	as	as	IN
cord-023168-cd7adns8	213	15	geographic	geographic	JJ
cord-023168-cd7adns8	213	16	distance	distance	NN
cord-023168-cd7adns8	213	17	,	,	,
cord-023168-cd7adns8	213	18	low	low	JJ
cord-023168-cd7adns8	213	19	motivation	motivation	NN
cord-023168-cd7adns8	213	20	and	and	CC
cord-023168-cd7adns8	213	21	poor	poor	JJ
cord-023168-cd7adns8	213	22	interpersonal	interpersonal	JJ
cord-023168-cd7adns8	213	23	skills	skill	NNS
cord-023168-cd7adns8	213	24	of	of	IN
cord-023168-cd7adns8	213	25	health	health	NN
cord-023168-cd7adns8	213	26	staff	staff	NN
cord-023168-cd7adns8	213	27	,	,	,
cord-023168-cd7adns8	213	28	poor	poor	JJ
cord-023168-cd7adns8	213	29	quality	quality	NN
cord-023168-cd7adns8	213	30	of	of	IN
cord-023168-cd7adns8	213	31	supplies	supply	NNS
cord-023168-cd7adns8	213	32	and	and	CC
cord-023168-cd7adns8	213	33	facilities	facility	NNS
cord-023168-cd7adns8	213	34	,	,	,
cord-023168-cd7adns8	213	35	insufficient	insufficient	JJ
cord-023168-cd7adns8	213	36	supply	supply	NN
cord-023168-cd7adns8	213	37	of	of	IN
cord-023168-cd7adns8	213	38	iron	iron	NN
cord-023168-cd7adns8	213	39	and	and	CC
cord-023168-cd7adns8	213	40	folic	folic	JJ
cord-023168-cd7adns8	213	41	acid	acid	NN
cord-023168-cd7adns8	213	42	pills	pill	NNS
cord-023168-cd7adns8	213	43	and	and	CC
cord-023168-cd7adns8	213	44	womens	womens	JJ
cord-023168-cd7adns8	213	45	'	'	POS
cord-023168-cd7adns8	213	46	poor	poor	JJ
cord-023168-cd7adns8	213	47	understanding	understanding	NN
cord-023168-cd7adns8	213	48	about	about	IN
cord-023168-cd7adns8	213	49	the	the	DT
cord-023168-cd7adns8	213	50	daily	daily	JJ
cord-023168-cd7adns8	213	51	use	use	NN
cord-023168-cd7adns8	213	52	of	of	IN
cord-023168-cd7adns8	213	53	supplements	supplement	NNS
cord-023168-cd7adns8	213	54	,	,	,
cord-023168-cd7adns8	213	55	especially	especially	RB
cord-023168-cd7adns8	213	56	in	in	IN
cord-023168-cd7adns8	213	57	the	the	DT
cord-023168-cd7adns8	213	58	face	face	NN
cord-023168-cd7adns8	213	59	of	of	IN
cord-023168-cd7adns8	213	60	common	common	JJ
cord-023168-cd7adns8	213	61	side	side	NN
cord-023168-cd7adns8	213	62	effects	effect	NNS
cord-023168-cd7adns8	213	63	.	.	.
cord-023168-cd7adns8	214	1	23	23	CD
cord-023168-cd7adns8	215	1	In	in	IN
cord-023168-cd7adns8	215	2	sub	sub	JJ
cord-023168-cd7adns8	215	3	-	-	JJ
cord-023168-cd7adns8	215	4	Saharan	Saharan	NNP
cord-023168-cd7adns8	215	5	Africa	Africa	NNP
cord-023168-cd7adns8	215	6	,	,	,
cord-023168-cd7adns8	215	7	the	the	DT
cord-023168-cd7adns8	215	8	acute	acute	JJ
cord-023168-cd7adns8	215	9	shortage	shortage	NN
cord-023168-cd7adns8	215	10	and	and	CC
cord-023168-cd7adns8	215	11	high	high	JJ
cord-023168-cd7adns8	215	12	turnover	turnover	NN
cord-023168-cd7adns8	215	13	of	of	IN
cord-023168-cd7adns8	215	14	health	health	NN
cord-023168-cd7adns8	215	15	workers	worker	NNS
cord-023168-cd7adns8	215	16	,	,	,
cord-023168-cd7adns8	215	17	and	and	CC
cord-023168-cd7adns8	215	18	lack	lack	NN
cord-023168-cd7adns8	215	19	of	of	IN
cord-023168-cd7adns8	215	20	time	time	NN
cord-023168-cd7adns8	215	21	have	have	VBP
cord-023168-cd7adns8	215	22	also	also	RB
cord-023168-cd7adns8	215	23	been	be	VBN
cord-023168-cd7adns8	215	24	shown	show	VBN
cord-023168-cd7adns8	215	25	to	to	TO
cord-023168-cd7adns8	215	26	contribute	contribute	VB
cord-023168-cd7adns8	215	27	to	to	IN
cord-023168-cd7adns8	215	28	ineffective	ineffective	JJ
cord-023168-cd7adns8	215	29	antenatal	antenatal	JJ
cord-023168-cd7adns8	215	30	measures	measure	NNS
cord-023168-cd7adns8	215	31	for	for	IN
cord-023168-cd7adns8	215	32	reducing	reduce	VBG
cord-023168-cd7adns8	215	33	anaemia	anaemia	NN
cord-023168-cd7adns8	215	34	.	.	.
cord-023168-cd7adns8	216	1	24	24	CD
cord-023168-cd7adns8	217	1	Interestingly	interestingly	RB
cord-023168-cd7adns8	217	2	,	,	,
cord-023168-cd7adns8	217	3	a	a	DT
cord-023168-cd7adns8	217	4	study	study	NN
cord-023168-cd7adns8	217	5	from	from	IN
cord-023168-cd7adns8	217	6	Bangladesh	Bangladesh	NNP
cord-023168-cd7adns8	217	7	showed	show	VBD
cord-023168-cd7adns8	217	8	that	that	IN
cord-023168-cd7adns8	217	9	the	the	DT
cord-023168-cd7adns8	217	10	first	first	JJ
cord-023168-cd7adns8	217	11	20	20	CD
cord-023168-cd7adns8	217	12	pills	pill	NNS
cord-023168-cd7adns8	217	13	(	(	-LRB-
cord-023168-cd7adns8	217	14	whether	whether	IN
cord-023168-cd7adns8	217	15	taken	take	VBN
cord-023168-cd7adns8	217	16	on	on	RP
cord-023168-cd7adns8	217	17	a	a	DT
cord-023168-cd7adns8	217	18	daily	daily	JJ
cord-023168-cd7adns8	217	19	basis	basis	NN
cord-023168-cd7adns8	217	20	or	or	CC
cord-023168-cd7adns8	217	21	less	less	RBR
cord-023168-cd7adns8	217	22	frequently	frequently	RB
cord-023168-cd7adns8	217	23	)	)	-RRB-
cord-023168-cd7adns8	217	24	yielded	yield	VBD
cord-023168-cd7adns8	217	25	most	most	JJS
cord-023168-cd7adns8	217	26	of	of	IN
cord-023168-cd7adns8	217	27	the	the	DT
cord-023168-cd7adns8	217	28	benefit	benefit	NN
cord-023168-cd7adns8	217	29	for	for	IN
cord-023168-cd7adns8	217	30	raising	raise	VBG
cord-023168-cd7adns8	217	31	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	217	32	levels	level	NNS
cord-023168-cd7adns8	217	33	,	,	,
cord-023168-cd7adns8	217	34	which	which	WDT
cord-023168-cd7adns8	217	35	suggests	suggest	VBZ
cord-023168-cd7adns8	217	36	that	that	IN
cord-023168-cd7adns8	217	37	currently	currently	RB
cord-023168-cd7adns8	217	38	recommended	recommend	VBN
cord-023168-cd7adns8	217	39	doses	dose	NNS
cord-023168-cd7adns8	217	40	may	may	MD
cord-023168-cd7adns8	217	41	be	be	VB
cord-023168-cd7adns8	217	42	higher	high	JJR
cord-023168-cd7adns8	217	43	than	than	IN
cord-023168-cd7adns8	217	44	necessary	necessary	JJ
cord-023168-cd7adns8	217	45	to	to	TO
cord-023168-cd7adns8	217	46	achieve	achieve	VB
cord-023168-cd7adns8	217	47	optimal	optimal	JJ
cord-023168-cd7adns8	217	48	outcomes	outcome	NNS
cord-023168-cd7adns8	217	49	,	,	,
cord-023168-cd7adns8	217	50	except	except	IN
cord-023168-cd7adns8	217	51	when	when	WRB
cord-023168-cd7adns8	217	52	anaemia	anaemia	NN
cord-023168-cd7adns8	217	53	is	be	VBZ
cord-023168-cd7adns8	217	54	very	very	RB
cord-023168-cd7adns8	217	55	severe	severe	JJ
cord-023168-cd7adns8	217	56	.	.	.
cord-023168-cd7adns8	218	1	25	25	CD
cord-023168-cd7adns8	218	2	 	 	_SP
cord-023168-cd7adns8	219	1	The	the	DT
cord-023168-cd7adns8	219	2	global	global	JJ
cord-023168-cd7adns8	219	3	burden	burden	NN
cord-023168-cd7adns8	219	4	of	of	IN
cord-023168-cd7adns8	219	5	iron	iron	NN
cord-023168-cd7adns8	219	6	deficiency	deficiency	NN
cord-023168-cd7adns8	219	7	has	have	VBZ
cord-023168-cd7adns8	219	8	been	be	VBN
cord-023168-cd7adns8	219	9	estimated	estimate	VBN
cord-023168-cd7adns8	219	10	from	from	IN
cord-023168-cd7adns8	219	11	anaemia	anaemia	NN
cord-023168-cd7adns8	219	12	prevalence	prevalence	NN
cord-023168-cd7adns8	219	13	surveys	survey	NNS
cord-023168-cd7adns8	219	14	,	,	,
cord-023168-cd7adns8	219	15	which	which	WDT
cord-023168-cd7adns8	219	16	include	include	VBP
cord-023168-cd7adns8	219	17	many	many	JJ
cord-023168-cd7adns8	219	18	different	different	JJ
cord-023168-cd7adns8	219	19	causes	cause	NNS
cord-023168-cd7adns8	219	20	of	of	IN
cord-023168-cd7adns8	219	21	anaemia	anaemia	NN
cord-023168-cd7adns8	219	22	so	so	IN
cord-023168-cd7adns8	219	23	data	datum	NNS
cord-023168-cd7adns8	219	24	may	may	MD
cord-023168-cd7adns8	219	25	be	be	VB
cord-023168-cd7adns8	219	26	unreliable	unreliable	JJ
cord-023168-cd7adns8	219	27	as	as	IN
cord-023168-cd7adns8	219	28	they	-PRON-	PRP
cord-023168-cd7adns8	219	29	are	be	VBP
cord-023168-cd7adns8	219	30	often	often	RB
cord-023168-cd7adns8	219	31	not	not	RB
cord-023168-cd7adns8	219	32	based	base	VBN
cord-023168-cd7adns8	219	33	on	on	IN
cord-023168-cd7adns8	219	34	proven	prove	VBN
cord-023168-cd7adns8	219	35	cases	case	NNS
cord-023168-cd7adns8	219	36	of	of	IN
cord-023168-cd7adns8	219	37	iron	iron	NN
cord-023168-cd7adns8	219	38	deficiency	deficiency	NN
cord-023168-cd7adns8	219	39	.	.	.
cord-023168-cd7adns8	220	1	WHO	who	WP
cord-023168-cd7adns8	220	2	estimates	estimate	VBZ
cord-023168-cd7adns8	220	3	that	that	IN
cord-023168-cd7adns8	220	4	globally	globally	RB
cord-023168-cd7adns8	220	5	41	41	CD
cord-023168-cd7adns8	220	6	%	%	NN
cord-023168-cd7adns8	220	7	of	of	IN
cord-023168-cd7adns8	220	8	women	woman	NNS
cord-023168-cd7adns8	220	9	and	and	CC
cord-023168-cd7adns8	220	10	27	27	CD
cord-023168-cd7adns8	220	11	%	%	NN
cord-023168-cd7adns8	220	12	of	of	IN
cord-023168-cd7adns8	220	13	pre	pre	JJ
cord-023168-cd7adns8	220	14	-	-	JJ
cord-023168-cd7adns8	220	15	school	school	JJ
cord-023168-cd7adns8	220	16	children	child	NNS
cord-023168-cd7adns8	220	17	are	be	VBP
cord-023168-cd7adns8	220	18	affected	affect	VBN
cord-023168-cd7adns8	220	19	by	by	IN
cord-023168-cd7adns8	220	20	iron	iron	NN
cord-023168-cd7adns8	220	21	-	-	HYPH
cord-023168-cd7adns8	220	22	deficiency	deficiency	NN
cord-023168-cd7adns8	220	23	anaemia	anaemia	NN
cord-023168-cd7adns8	220	24	,	,	,
cord-023168-cd7adns8	220	25	making	make	VBG
cord-023168-cd7adns8	220	26	it	-PRON-	PRP
cord-023168-cd7adns8	220	27	number	number	NN
cord-023168-cd7adns8	220	28	15	15	CD
cord-023168-cd7adns8	220	29	of	of	IN
cord-023168-cd7adns8	220	30	selected	select	VBN
cord-023168-cd7adns8	220	31	risk	risk	NN
cord-023168-cd7adns8	220	32	factors	factor	NNS
cord-023168-cd7adns8	220	33	for	for	IN
cord-023168-cd7adns8	220	34	preventable	preventable	JJ
cord-023168-cd7adns8	220	35	death	death	NN
cord-023168-cd7adns8	220	36	and	and	CC
cord-023168-cd7adns8	220	37	disability	disability	NN
cord-023168-cd7adns8	220	38	worldwide	worldwide	RB
cord-023168-cd7adns8	220	39	.	.	.
cord-023168-cd7adns8	221	1	20	20	CD
cord-023168-cd7adns8	221	2	Iron	Iron	NNP
cord-023168-cd7adns8	221	3	deficiency	deficiency	NN
cord-023168-cd7adns8	221	4	begins	begin	VBZ
cord-023168-cd7adns8	221	5	in	in	IN
cord-023168-cd7adns8	221	6	childhood	childhood	NN
cord-023168-cd7adns8	221	7	,	,	,
cord-023168-cd7adns8	221	8	worsens	worsen	VBZ
cord-023168-cd7adns8	221	9	during	during	IN
cord-023168-cd7adns8	221	10	adolescence	adolescence	NN
cord-023168-cd7adns8	221	11	in	in	IN
cord-023168-cd7adns8	221	12	girls	girl	NNS
cord-023168-cd7adns8	221	13	and	and	CC
cord-023168-cd7adns8	221	14	is	be	VBZ
cord-023168-cd7adns8	221	15	aggravated	aggravate	VBN
cord-023168-cd7adns8	221	16	during	during	IN
cord-023168-cd7adns8	221	17	pregnancy	pregnancy	NN
cord-023168-cd7adns8	221	18	.	.	.
cord-023168-cd7adns8	222	1	Poor	poor	JJ
cord-023168-cd7adns8	222	2	iron	iron	NN
cord-023168-cd7adns8	222	3	stores	store	NNS
cord-023168-cd7adns8	222	4	at	at	IN
cord-023168-cd7adns8	222	5	birth	birth	NN
cord-023168-cd7adns8	222	6	,	,	,
cord-023168-cd7adns8	222	7	low	low	JJ
cord-023168-cd7adns8	222	8	iron	iron	NN
cord-023168-cd7adns8	222	9	content	content	NN
cord-023168-cd7adns8	222	10	of	of	IN
cord-023168-cd7adns8	222	11	breast	breast	NN
cord-023168-cd7adns8	222	12	milk	milk	NN
cord-023168-cd7adns8	222	13	and	and	CC
cord-023168-cd7adns8	222	14	low	low	JJ
cord-023168-cd7adns8	222	15	dietary	dietary	JJ
cord-023168-cd7adns8	222	16	iron	iron	NN
cord-023168-cd7adns8	222	17	intake	intake	NN
cord-023168-cd7adns8	222	18	throughout	throughout	IN
cord-023168-cd7adns8	222	19	infancy	infancy	NN
cord-023168-cd7adns8	222	20	and	and	CC
cord-023168-cd7adns8	222	21	childhood	childhood	NN
cord-023168-cd7adns8	222	22	result	result	NN
cord-023168-cd7adns8	222	23	in	in	IN
cord-023168-cd7adns8	222	24	high	high	JJ
cord-023168-cd7adns8	222	25	prevalence	prevalence	NN
cord-023168-cd7adns8	222	26	of	of	IN
cord-023168-cd7adns8	222	27	anaemia	anaemia	NN
cord-023168-cd7adns8	222	28	in	in	IN
cord-023168-cd7adns8	222	29	childhood	childhood	NN
cord-023168-cd7adns8	222	30	.	.	.
cord-023168-cd7adns8	223	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	223	2	is	be	VBZ
cord-023168-cd7adns8	223	3	exacerbated	exacerbate	VBN
cord-023168-cd7adns8	223	4	by	by	IN
cord-023168-cd7adns8	223	5	increased	increase	VBN
cord-023168-cd7adns8	223	6	requirements	requirement	NNS
cord-023168-cd7adns8	223	7	during	during	IN
cord-023168-cd7adns8	223	8	adolescence	adolescence	NN
cord-023168-cd7adns8	223	9	and	and	CC
cord-023168-cd7adns8	223	10	iron	iron	NN
cord-023168-cd7adns8	223	11	loss	loss	NN
cord-023168-cd7adns8	223	12	from	from	IN
cord-023168-cd7adns8	223	13	menstruation	menstruation	NN
cord-023168-cd7adns8	223	14	and	and	CC
cord-023168-cd7adns8	223	15	is	be	VBZ
cord-023168-cd7adns8	223	16	often	often	RB
cord-023168-cd7adns8	223	17	compounded	compound	VBN
cord-023168-cd7adns8	223	18	by	by	IN
cord-023168-cd7adns8	223	19	the	the	DT
cord-023168-cd7adns8	223	20	lack	lack	NN
cord-023168-cd7adns8	223	21	of	of	IN
cord-023168-cd7adns8	223	22	adequate	adequate	JJ
cord-023168-cd7adns8	223	23	nutrition	nutrition	NN
cord-023168-cd7adns8	223	24	.	.	.
cord-023168-cd7adns8	224	1	The	the	DT
cord-023168-cd7adns8	224	2	situation	situation	NN
cord-023168-cd7adns8	224	3	is	be	VBZ
cord-023168-cd7adns8	224	4	worsened	worsen	VBN
cord-023168-cd7adns8	224	5	by	by	IN
cord-023168-cd7adns8	224	6	pregnancy	pregnancy	NN
cord-023168-cd7adns8	224	7	when	when	WRB
cord-023168-cd7adns8	224	8	iron	iron	NN
cord-023168-cd7adns8	224	9	requirement	requirement	NN
cord-023168-cd7adns8	224	10	is	be	VBZ
cord-023168-cd7adns8	224	11	approximately	approximately	RB
cord-023168-cd7adns8	224	12	two	two	CD
cord-023168-cd7adns8	224	13	times	time	NNS
cord-023168-cd7adns8	224	14	higher	high	JJR
cord-023168-cd7adns8	224	15	than	than	IN
cord-023168-cd7adns8	224	16	in	in	IN
cord-023168-cd7adns8	224	17	a	a	DT
cord-023168-cd7adns8	224	18	nonpregnant	nonpregnant	JJ
cord-023168-cd7adns8	224	19	state	state	NN
cord-023168-cd7adns8	224	20	.	.	.
cord-023168-cd7adns8	225	1	Iron	iron	NN
cord-023168-cd7adns8	225	2	deficiency	deficiency	NN
cord-023168-cd7adns8	225	3	should	should	MD
cord-023168-cd7adns8	225	4	not	not	RB
cord-023168-cd7adns8	225	5	be	be	VB
cord-023168-cd7adns8	225	6	considered	consider	VBN
cord-023168-cd7adns8	225	7	a	a	DT
cord-023168-cd7adns8	225	8	diagnosis	diagnosis	NN
cord-023168-cd7adns8	225	9	but	but	CC
cord-023168-cd7adns8	225	10	a	a	DT
cord-023168-cd7adns8	225	11	secondary	secondary	JJ
cord-023168-cd7adns8	225	12	outcome	outcome	NN
cord-023168-cd7adns8	225	13	due	due	IN
cord-023168-cd7adns8	225	14	to	to	IN
cord-023168-cd7adns8	225	15	an	an	DT
cord-023168-cd7adns8	225	16	underlying	underlying	JJ
cord-023168-cd7adns8	225	17	medical	medical	JJ
cord-023168-cd7adns8	225	18	condition	condition	NN
cord-023168-cd7adns8	225	19	.	.	.
cord-023168-cd7adns8	226	1	Although	although	IN
cord-023168-cd7adns8	226	2	it	-PRON-	PRP
cord-023168-cd7adns8	226	3	may	may	MD
cord-023168-cd7adns8	226	4	be	be	VB
cord-023168-cd7adns8	226	5	a	a	DT
cord-023168-cd7adns8	226	6	physiological	physiological	JJ
cord-023168-cd7adns8	226	7	response	response	NN
cord-023168-cd7adns8	226	8	to	to	IN
cord-023168-cd7adns8	226	9	rapid	rapid	JJ
cord-023168-cd7adns8	226	10	growth	growth	NN
cord-023168-cd7adns8	226	11	or	or	CC
cord-023168-cd7adns8	226	12	increased	increase	VBN
cord-023168-cd7adns8	226	13	requirements	requirement	NNS
cord-023168-cd7adns8	226	14	during	during	IN
cord-023168-cd7adns8	226	15	childhood	childhood	NN
cord-023168-cd7adns8	226	16	and	and	CC
cord-023168-cd7adns8	226	17	pregnancy	pregnancy	NN
cord-023168-cd7adns8	226	18	,	,	,
cord-023168-cd7adns8	226	19	it	-PRON-	PRP
cord-023168-cd7adns8	226	20	still	still	RB
cord-023168-cd7adns8	226	21	requires	require	VBZ
cord-023168-cd7adns8	226	22	treatment	treatment	NN
cord-023168-cd7adns8	226	23	due	due	IN
cord-023168-cd7adns8	226	24	to	to	IN
cord-023168-cd7adns8	226	25	potential	potential	JJ
cord-023168-cd7adns8	226	26	deleterious	deleterious	JJ
cord-023168-cd7adns8	226	27	consequences	consequence	NNS
cord-023168-cd7adns8	226	28	.	.	.
cord-023168-cd7adns8	227	1	Many	many	JJ
cord-023168-cd7adns8	227	2	of	of	IN
cord-023168-cd7adns8	227	3	the	the	DT
cord-023168-cd7adns8	227	4	chronic	chronic	JJ
cord-023168-cd7adns8	227	5	effects	effect	NNS
cord-023168-cd7adns8	227	6	of	of	IN
cord-023168-cd7adns8	227	7	iron	iron	NN
cord-023168-cd7adns8	227	8	deficiency	deficiency	NN
cord-023168-cd7adns8	227	9	may	may	MD
cord-023168-cd7adns8	227	10	develop	develop	VB
cord-023168-cd7adns8	227	11	before	before	IN
cord-023168-cd7adns8	227	12	the	the	DT
cord-023168-cd7adns8	227	13	clinical	clinical	JJ
cord-023168-cd7adns8	227	14	and	and	CC
cord-023168-cd7adns8	227	15	laboratory	laboratory	JJ
cord-023168-cd7adns8	227	16	evidence	evidence	NN
cord-023168-cd7adns8	227	17	of	of	IN
cord-023168-cd7adns8	227	18	anaemia	anaemia	NN
cord-023168-cd7adns8	227	19	becomes	become	VBZ
cord-023168-cd7adns8	227	20	apparent	apparent	JJ
cord-023168-cd7adns8	227	21	.	.	.
cord-023168-cd7adns8	228	1	The	the	DT
cord-023168-cd7adns8	228	2	biochemical	biochemical	JJ
cord-023168-cd7adns8	228	3	evidence	evidence	NN
cord-023168-cd7adns8	228	4	for	for	IN
cord-023168-cd7adns8	228	5	iron	iron	NN
cord-023168-cd7adns8	228	6	deficiency	deficiency	NN
cord-023168-cd7adns8	228	7	occurs	occur	VBZ
cord-023168-cd7adns8	228	8	in	in	IN
cord-023168-cd7adns8	228	9	several	several	JJ
cord-023168-cd7adns8	228	10	steps	step	NNS
cord-023168-cd7adns8	228	11	.	.	.
cord-023168-cd7adns8	229	1	26	26	CD
cord-023168-cd7adns8	230	1	Initially	initially	RB
cord-023168-cd7adns8	230	2	,	,	,
cord-023168-cd7adns8	230	3	iron	iron	NN
cord-023168-cd7adns8	230	4	stores	store	NNS
cord-023168-cd7adns8	230	5	in	in	IN
cord-023168-cd7adns8	230	6	the	the	DT
cord-023168-cd7adns8	230	7	bone	bone	NN
cord-023168-cd7adns8	230	8	marrow	marrow	NN
cord-023168-cd7adns8	230	9	are	be	VBP
cord-023168-cd7adns8	230	10	depleted	deplete	VBN
cord-023168-cd7adns8	230	11	as	as	IN
cord-023168-cd7adns8	230	12	reflected	reflect	VBN
cord-023168-cd7adns8	230	13	by	by	IN
cord-023168-cd7adns8	230	14	a	a	DT
cord-023168-cd7adns8	230	15	decreased	decrease	VBN
cord-023168-cd7adns8	230	16	serum	serum	NN
cord-023168-cd7adns8	230	17	ferritin	ferritin	NN
cord-023168-cd7adns8	230	18	.	.	.
cord-023168-cd7adns8	231	1	The	the	DT
cord-023168-cd7adns8	231	2	total	total	JJ
cord-023168-cd7adns8	231	3	iron	iron	NN
cord-023168-cd7adns8	231	4	-	-	HYPH
cord-023168-cd7adns8	231	5	binding	bind	VBG
cord-023168-cd7adns8	231	6	capacity	capacity	NN
cord-023168-cd7adns8	231	7	then	then	RB
cord-023168-cd7adns8	231	8	starts	start	VBZ
cord-023168-cd7adns8	231	9	to	to	TO
cord-023168-cd7adns8	231	10	rise	rise	VB
cord-023168-cd7adns8	231	11	,	,	,
cord-023168-cd7adns8	231	12	while	while	IN
cord-023168-cd7adns8	231	13	the	the	DT
cord-023168-cd7adns8	231	14	serum	serum	NN
cord-023168-cd7adns8	231	15	iron	iron	NN
cord-023168-cd7adns8	231	16	saturation	saturation	NN
cord-023168-cd7adns8	231	17	begins	begin	VBZ
cord-023168-cd7adns8	231	18	to	to	TO
cord-023168-cd7adns8	231	19	fall	fall	VB
cord-023168-cd7adns8	231	20	before	before	IN
cord-023168-cd7adns8	231	21	microcytosis	microcytosis	NNP
cord-023168-cd7adns8	231	22	and	and	CC
cord-023168-cd7adns8	231	23	a	a	DT
cord-023168-cd7adns8	231	24	drop	drop	NN
cord-023168-cd7adns8	231	25	in	in	IN
cord-023168-cd7adns8	231	26	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	231	27	ensue	ensue	NN
cord-023168-cd7adns8	231	28	.	.	.
cord-023168-cd7adns8	232	1	There	there	EX
cord-023168-cd7adns8	232	2	have	have	VBP
cord-023168-cd7adns8	232	3	been	be	VBN
cord-023168-cd7adns8	232	4	attempts	attempt	NNS
cord-023168-cd7adns8	232	5	to	to	TO
cord-023168-cd7adns8	232	6	identify	identify	VB
cord-023168-cd7adns8	232	7	this	this	DT
cord-023168-cd7adns8	232	8	early	early	JJ
cord-023168-cd7adns8	232	9	iron	iron	NN
cord-023168-cd7adns8	232	10	deficiency	deficiency	NN
cord-023168-cd7adns8	232	11	before	before	IN
cord-023168-cd7adns8	232	12	anaemia	anaemia	NN
cord-023168-cd7adns8	232	13	develops	develop	VBZ
cord-023168-cd7adns8	232	14	in	in	IN
cord-023168-cd7adns8	232	15	order	order	NN
cord-023168-cd7adns8	232	16	to	to	TO
cord-023168-cd7adns8	232	17	improve	improve	VB
cord-023168-cd7adns8	232	18	neurological	neurological	JJ
cord-023168-cd7adns8	232	19	and	and	CC
cord-023168-cd7adns8	232	20	psychomotor	psychomotor	JJ
cord-023168-cd7adns8	232	21	functions	function	NNS
cord-023168-cd7adns8	232	22	in	in	IN
cord-023168-cd7adns8	232	23	children	child	NNS
cord-023168-cd7adns8	232	24	and	and	CC
cord-023168-cd7adns8	232	25	work	work	NN
cord-023168-cd7adns8	232	26	performance	performance	NN
cord-023168-cd7adns8	232	27	in	in	IN
cord-023168-cd7adns8	232	28	adults	adult	NNS
cord-023168-cd7adns8	232	29	through	through	IN
cord-023168-cd7adns8	232	30	widespread	widespread	JJ
cord-023168-cd7adns8	232	31	iron	iron	NN
cord-023168-cd7adns8	232	32	supplementation	supplementation	NN
cord-023168-cd7adns8	232	33	.	.	.
cord-023168-cd7adns8	233	1	However	however	RB
cord-023168-cd7adns8	233	2	,	,	,
cord-023168-cd7adns8	233	3	there	there	EX
cord-023168-cd7adns8	233	4	are	be	VBP
cord-023168-cd7adns8	233	5	concerns	concern	NNS
cord-023168-cd7adns8	233	6	that	that	IN
cord-023168-cd7adns8	233	7	iron	iron	NN
cord-023168-cd7adns8	233	8	excess	excess	NN
cord-023168-cd7adns8	233	9	may	may	MD
cord-023168-cd7adns8	233	10	promote	promote	VB
cord-023168-cd7adns8	233	11	infections	infection	NNS
cord-023168-cd7adns8	233	12	,	,	,
cord-023168-cd7adns8	233	13	especially	especially	RB
cord-023168-cd7adns8	233	14	in	in	IN
cord-023168-cd7adns8	233	15	malarious	malarious	JJ
cord-023168-cd7adns8	233	16	areas	area	NNS
cord-023168-cd7adns8	233	17	.	.	.
cord-023168-cd7adns8	234	1	A	a	DT
cord-023168-cd7adns8	234	2	range	range	NN
cord-023168-cd7adns8	234	3	of	of	IN
cord-023168-cd7adns8	234	4	laboratory	laboratory	NN
cord-023168-cd7adns8	234	5	investigations	investigation	NNS
cord-023168-cd7adns8	234	6	are	be	VBP
cord-023168-cd7adns8	234	7	usually	usually	RB
cord-023168-cd7adns8	234	8	necessary	necessary	JJ
cord-023168-cd7adns8	234	9	if	if	IN
cord-023168-cd7adns8	234	10	iron	iron	NN
cord-023168-cd7adns8	234	11	deficiency	deficiency	NN
cord-023168-cd7adns8	234	12	is	be	VBZ
cord-023168-cd7adns8	234	13	suspected	suspect	VBN
cord-023168-cd7adns8	234	14	(	(	-LRB-
cord-023168-cd7adns8	234	15	Table	table	NN
cord-023168-cd7adns8	234	16	65	65	CD
cord-023168-cd7adns8	234	17	.4	.4	CD
cord-023168-cd7adns8	234	18	)	)	-RRB-
cord-023168-cd7adns8	235	1	27	27	CD
cord-023168-cd7adns8	235	2	-	-	SYM
cord-023168-cd7adns8	235	3	30	30	CD
cord-023168-cd7adns8	235	4	because	because	IN
cord-023168-cd7adns8	235	5	once	once	IN
cord-023168-cd7adns8	235	6	the	the	DT
cord-023168-cd7adns8	235	7	diagnosis	diagnosis	NN
cord-023168-cd7adns8	235	8	is	be	VBZ
cord-023168-cd7adns8	235	9	confirmed	confirm	VBN
cord-023168-cd7adns8	235	10	,	,	,
cord-023168-cd7adns8	235	11	a	a	DT
cord-023168-cd7adns8	235	12	search	search	NN
cord-023168-cd7adns8	235	13	for	for	IN
cord-023168-cd7adns8	235	14	the	the	DT
cord-023168-cd7adns8	235	15	precise	precise	JJ
cord-023168-cd7adns8	235	16	cause	cause	NN
cord-023168-cd7adns8	235	17	is	be	VBZ
cord-023168-cd7adns8	235	18	necessary	necessary	JJ
cord-023168-cd7adns8	235	19	.	.	.
cord-023168-cd7adns8	236	1	A	a	DT
cord-023168-cd7adns8	236	2	systematic	systematic	JJ
cord-023168-cd7adns8	236	3	approach	approach	NN
cord-023168-cd7adns8	236	4	to	to	IN
cord-023168-cd7adns8	236	5	the	the	DT
cord-023168-cd7adns8	236	6	investigation	investigation	NN
cord-023168-cd7adns8	236	7	of	of	IN
cord-023168-cd7adns8	236	8	iron	iron	NN
cord-023168-cd7adns8	236	9	deficiency	deficiency	NN
cord-023168-cd7adns8	236	10	(	(	-LRB-
cord-023168-cd7adns8	236	11	see	see	VB
cord-023168-cd7adns8	236	12	below	below	RB
cord-023168-cd7adns8	236	13	)	)	-RRB-
cord-023168-cd7adns8	236	14	is	be	VBZ
cord-023168-cd7adns8	236	15	required	require	VBN
cord-023168-cd7adns8	236	16	based	base	VBN
cord-023168-cd7adns8	236	17	on	on	IN
cord-023168-cd7adns8	236	18	an	an	DT
cord-023168-cd7adns8	236	19	understanding	understanding	NN
cord-023168-cd7adns8	236	20	of	of	IN
cord-023168-cd7adns8	236	21	alterations	alteration	NNS
cord-023168-cd7adns8	236	22	in	in	IN
cord-023168-cd7adns8	236	23	the	the	DT
cord-023168-cd7adns8	236	24	iron	iron	NN
cord-023168-cd7adns8	236	25	absorption	absorption	NN
cord-023168-cd7adns8	236	26	and	and	CC
cord-023168-cd7adns8	236	27	transport	transport	NN
cord-023168-cd7adns8	236	28	cycle	cycle	NN
cord-023168-cd7adns8	236	29	.	.	.
cord-023168-cd7adns8	237	1	•	•	NNP
cord-023168-cd7adns8	238	1	Deficient	deficient	JJ
cord-023168-cd7adns8	238	2	intake	intake	NN
cord-023168-cd7adns8	239	1	(	(	-LRB-
cord-023168-cd7adns8	239	2	cow	cow	NN
cord-023168-cd7adns8	239	3	's	's	POS
cord-023168-cd7adns8	239	4	milk	milk	NN
cord-023168-cd7adns8	239	5	has	have	VBZ
cord-023168-cd7adns8	239	6	poor	poor	JJ
cord-023168-cd7adns8	239	7	iron	iron	NN
cord-023168-cd7adns8	239	8	content	content	NN
cord-023168-cd7adns8	239	9	and	and	CC
cord-023168-cd7adns8	239	10	can	can	MD
cord-023168-cd7adns8	239	11	cause	cause	VB
cord-023168-cd7adns8	239	12	gut	gut	NN
cord-023168-cd7adns8	239	13	blood	blood	NN
cord-023168-cd7adns8	239	14	loss	loss	NN
cord-023168-cd7adns8	239	15	in	in	IN
cord-023168-cd7adns8	239	16	some	some	DT
cord-023168-cd7adns8	239	17	infants	infant	NNS
cord-023168-cd7adns8	239	18	)	)	-RRB-
cord-023168-cd7adns8	240	1	•	•	NFP
cord-023168-cd7adns8	240	2	Rare	rare	JJ
cord-023168-cd7adns8	240	3	defects	defect	NNS
cord-023168-cd7adns8	240	4	of	of	IN
cord-023168-cd7adns8	240	5	haem	haem	NN
cord-023168-cd7adns8	240	6	biosynthesis	biosynthesis	NN
cord-023168-cd7adns8	240	7	and	and	CC
cord-023168-cd7adns8	240	8	iron	iron	NN
cord-023168-cd7adns8	240	9	transport	transport	NN
cord-023168-cd7adns8	240	10	.	.	.
cord-023168-cd7adns8	241	1	Iron	iron	NN
cord-023168-cd7adns8	241	2	-	-	HYPH
cord-023168-cd7adns8	241	3	deficient	deficient	JJ
cord-023168-cd7adns8	241	4	individuals	individual	NNS
cord-023168-cd7adns8	241	5	may	may	MD
cord-023168-cd7adns8	241	6	have	have	VB
cord-023168-cd7adns8	241	7	no	no	DT
cord-023168-cd7adns8	241	8	symptoms	symptom	NNS
cord-023168-cd7adns8	241	9	.	.	.
cord-023168-cd7adns8	242	1	Excessive	excessive	JJ
cord-023168-cd7adns8	242	2	fatigue	fatigue	NN
cord-023168-cd7adns8	242	3	and	and	CC
cord-023168-cd7adns8	242	4	other	other	JJ
cord-023168-cd7adns8	242	5	nonspecific	nonspecific	JJ
cord-023168-cd7adns8	242	6	signs	sign	NNS
cord-023168-cd7adns8	242	7	of	of	IN
cord-023168-cd7adns8	242	8	anaemia	anaemia	NN
cord-023168-cd7adns8	242	9	become	become	VBP
cord-023168-cd7adns8	242	10	more	more	RBR
cord-023168-cd7adns8	242	11	pronounced	pronounced	JJ
cord-023168-cd7adns8	242	12	as	as	IN
cord-023168-cd7adns8	242	13	anaemia	anaemia	NN
cord-023168-cd7adns8	242	14	develops	develop	VBZ
cord-023168-cd7adns8	242	15	.	.	.
cord-023168-cd7adns8	243	1	Consumption	consumption	NN
cord-023168-cd7adns8	243	2	of	of	IN
cord-023168-cd7adns8	243	3	unusual	unusual	JJ
cord-023168-cd7adns8	243	4	'	'	``
cord-023168-cd7adns8	243	5	foods	food	NNS
cord-023168-cd7adns8	243	6	'	'	POS
cord-023168-cd7adns8	243	7	such	such	JJ
cord-023168-cd7adns8	243	8	as	as	IN
cord-023168-cd7adns8	243	9	ice	ice	NN
cord-023168-cd7adns8	243	10	and	and	CC
cord-023168-cd7adns8	243	11	paint	paint	NN
cord-023168-cd7adns8	243	12	or	or	CC
cord-023168-cd7adns8	243	13	'	'	``
cord-023168-cd7adns8	243	14	pica	pica	NN
cord-023168-cd7adns8	243	15	'	'	''
cord-023168-cd7adns8	243	16	only	only	RB
cord-023168-cd7adns8	243	17	occurs	occur	VBZ
cord-023168-cd7adns8	243	18	in	in	IN
cord-023168-cd7adns8	243	19	a	a	DT
cord-023168-cd7adns8	243	20	minority	minority	NN
cord-023168-cd7adns8	243	21	of	of	IN
cord-023168-cd7adns8	243	22	individuals	individual	NNS
cord-023168-cd7adns8	243	23	.	.	.
cord-023168-cd7adns8	244	1	Physical	physical	JJ
cord-023168-cd7adns8	244	2	examination	examination	NN
cord-023168-cd7adns8	244	3	may	may	MD
cord-023168-cd7adns8	244	4	reveal	reveal	VB
cord-023168-cd7adns8	244	5	stomatitis	stomatitis	NN
cord-023168-cd7adns8	244	6	,	,	,
cord-023168-cd7adns8	244	7	glossitis	glossitis	NNP
cord-023168-cd7adns8	244	8	,	,	,
cord-023168-cd7adns8	244	9	koilonychia	koilonychia	NNP
cord-023168-cd7adns8	244	10	(	(	-LRB-
cord-023168-cd7adns8	244	11	spoon	spoon	NN
cord-023168-cd7adns8	244	12	-	-	HYPH
cord-023168-cd7adns8	244	13	shaped	shape	VBN
cord-023168-cd7adns8	244	14	nails	nail	NNS
cord-023168-cd7adns8	244	15	)	)	-RRB-
cord-023168-cd7adns8	244	16	and	and	CC
cord-023168-cd7adns8	244	17	hair	hair	NN
cord-023168-cd7adns8	244	18	loss	loss	NN
cord-023168-cd7adns8	244	19	.	.	.
cord-023168-cd7adns8	245	1	Oesophageal	Oesophageal	NNP
cord-023168-cd7adns8	245	2	webs	web	NNS
cord-023168-cd7adns8	245	3	have	have	VBP
cord-023168-cd7adns8	245	4	been	be	VBN
cord-023168-cd7adns8	245	5	described	describe	VBN
cord-023168-cd7adns8	245	6	in	in	IN
cord-023168-cd7adns8	245	7	the	the	DT
cord-023168-cd7adns8	245	8	Plummer	Plummer	NNP
cord-023168-cd7adns8	245	9	-	-	HYPH
cord-023168-cd7adns8	245	10	Vinson	Vinson	NNP
cord-023168-cd7adns8	245	11	syndrome	syndrome	NN
cord-023168-cd7adns8	245	12	but	but	CC
cord-023168-cd7adns8	245	13	are	be	VBP
cord-023168-cd7adns8	245	14	rare	rare	JJ
cord-023168-cd7adns8	245	15	and	and	CC
cord-023168-cd7adns8	245	16	may	may	MD
cord-023168-cd7adns8	245	17	respond	respond	VB
cord-023168-cd7adns8	245	18	to	to	IN
cord-023168-cd7adns8	245	19	iron	iron	NN
cord-023168-cd7adns8	245	20	replacement	replacement	NN
cord-023168-cd7adns8	245	21	.	.	.
cord-023168-cd7adns8	246	1	Since	since	IN
cord-023168-cd7adns8	246	2	iron	iron	NN
cord-023168-cd7adns8	246	3	is	be	VBZ
cord-023168-cd7adns8	246	4	important	important	JJ
cord-023168-cd7adns8	246	5	in	in	IN
cord-023168-cd7adns8	246	6	neuromuscular	neuromuscular	JJ
cord-023168-cd7adns8	246	7	development	development	NN
cord-023168-cd7adns8	246	8	,	,	,
cord-023168-cd7adns8	246	9	several	several	JJ
cord-023168-cd7adns8	246	10	features	feature	NNS
cord-023168-cd7adns8	246	11	of	of	IN
cord-023168-cd7adns8	246	12	anaemia	anaemia	NN
cord-023168-cd7adns8	246	13	described	describe	VBN
cord-023168-cd7adns8	246	14	in	in	IN
cord-023168-cd7adns8	246	15	Table	Table	NNP
cord-023168-cd7adns8	246	16	65	65	CD
cord-023168-cd7adns8	246	17	.3	.3	NFP
cord-023168-cd7adns8	246	18	may	may	MD
cord-023168-cd7adns8	246	19	be	be	VB
cord-023168-cd7adns8	246	20	related	relate	VBN
cord-023168-cd7adns8	246	21	to	to	IN
cord-023168-cd7adns8	246	22	iron	iron	NN
cord-023168-cd7adns8	246	23	deficiency	deficiency	NN
cord-023168-cd7adns8	246	24	.	.	.
cord-023168-cd7adns8	247	1	Treatment	treatment	NN
cord-023168-cd7adns8	247	2	of	of	IN
cord-023168-cd7adns8	247	3	iron	iron	NN
cord-023168-cd7adns8	247	4	deficiency	deficiency	NN
cord-023168-cd7adns8	247	5	is	be	VBZ
cord-023168-cd7adns8	247	6	with	with	IN
cord-023168-cd7adns8	247	7	dietary	dietary	JJ
cord-023168-cd7adns8	247	8	modifications	modification	NNS
cord-023168-cd7adns8	247	9	and	and	CC
cord-023168-cd7adns8	247	10	oral	oral	JJ
cord-023168-cd7adns8	247	11	or	or	CC
cord-023168-cd7adns8	247	12	parenteral	parenteral	JJ
cord-023168-cd7adns8	247	13	iron	iron	NN
cord-023168-cd7adns8	247	14	.	.	.
cord-023168-cd7adns8	248	1	31	31	CD
cord-023168-cd7adns8	248	2	Blood	blood	NN
cord-023168-cd7adns8	248	3	transfusions	transfusion	NNS
cord-023168-cd7adns8	248	4	should	should	MD
cord-023168-cd7adns8	248	5	be	be	VB
cord-023168-cd7adns8	248	6	reserved	reserve	VBN
cord-023168-cd7adns8	248	7	for	for	IN
cord-023168-cd7adns8	248	8	those	those	DT
cord-023168-cd7adns8	248	9	with	with	IN
cord-023168-cd7adns8	248	10	severe	severe	JJ
cord-023168-cd7adns8	248	11	symptoms	symptom	NNS
cord-023168-cd7adns8	248	12	especially	especially	RB
cord-023168-cd7adns8	248	13	if	if	IN
cord-023168-cd7adns8	248	14	the	the	DT
cord-023168-cd7adns8	248	15	anaemia	anaemia	NN
cord-023168-cd7adns8	248	16	developed	develop	VBD
cord-023168-cd7adns8	248	17	rapidly	rapidly	RB
cord-023168-cd7adns8	248	18	.	.	.
cord-023168-cd7adns8	249	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	249	2	levels	level	NNS
cord-023168-cd7adns8	249	3	alone	alone	RB
cord-023168-cd7adns8	249	4	should	should	MD
cord-023168-cd7adns8	249	5	not	not	RB
cord-023168-cd7adns8	249	6	be	be	VB
cord-023168-cd7adns8	249	7	considered	consider	VBN
cord-023168-cd7adns8	249	8	as	as	IN
cord-023168-cd7adns8	249	9	a	a	DT
cord-023168-cd7adns8	249	10	criterion	criterion	NN
cord-023168-cd7adns8	249	11	for	for	IN
cord-023168-cd7adns8	249	12	transfusion	transfusion	NN
cord-023168-cd7adns8	249	13	since	since	IN
cord-023168-cd7adns8	249	14	very	very	RB
cord-023168-cd7adns8	249	15	low	low	JJ
cord-023168-cd7adns8	249	16	levels	level	NNS
cord-023168-cd7adns8	249	17	(	(	-LRB-
cord-023168-cd7adns8	249	18	e.g.	e.g.	RB
cord-023168-cd7adns8	249	19	10	10	CD
cord-023168-cd7adns8	249	20	-	-	SYM
cord-023168-cd7adns8	249	21	30	30	CD
cord-023168-cd7adns8	249	22	g	g	NN
cord-023168-cd7adns8	249	23	/	/	SYM
cord-023168-cd7adns8	249	24	L	L	NNP
cord-023168-cd7adns8	249	25	)	)	-RRB-
cord-023168-cd7adns8	249	26	may	may	MD
cord-023168-cd7adns8	249	27	be	be	VB
cord-023168-cd7adns8	249	28	appropriately	appropriately	RB
cord-023168-cd7adns8	249	29	treated	treat	VBN
cord-023168-cd7adns8	249	30	with	with	IN
cord-023168-cd7adns8	249	31	oral	oral	JJ
cord-023168-cd7adns8	249	32	iron	iron	NN
cord-023168-cd7adns8	249	33	if	if	IN
cord-023168-cd7adns8	249	34	anaemia	anaemia	NN
cord-023168-cd7adns8	249	35	has	have	VBZ
cord-023168-cd7adns8	249	36	developed	develop	VBN
cord-023168-cd7adns8	249	37	slowly	slowly	RB
cord-023168-cd7adns8	249	38	.	.	.
cord-023168-cd7adns8	250	1	Intravenous	intravenous	JJ
cord-023168-cd7adns8	250	2	iron	iron	NN
cord-023168-cd7adns8	250	3	should	should	MD
cord-023168-cd7adns8	250	4	only	only	RB
cord-023168-cd7adns8	250	5	be	be	VB
cord-023168-cd7adns8	250	6	considered	consider	VBN
cord-023168-cd7adns8	250	7	in	in	IN
cord-023168-cd7adns8	250	8	cases	case	NNS
cord-023168-cd7adns8	250	9	of	of	IN
cord-023168-cd7adns8	250	10	poor	poor	JJ
cord-023168-cd7adns8	250	11	response	response	NN
cord-023168-cd7adns8	250	12	or	or	CC
cord-023168-cd7adns8	250	13	intolerance	intolerance	NN
cord-023168-cd7adns8	250	14	to	to	IN
cord-023168-cd7adns8	250	15	oral	oral	JJ
cord-023168-cd7adns8	250	16	iron	iron	NN
cord-023168-cd7adns8	250	17	.	.	.
cord-023168-cd7adns8	251	1	Cereals	cereal	NNS
cord-023168-cd7adns8	251	2	,	,	,
cord-023168-cd7adns8	251	3	poultry	poultry	NN
cord-023168-cd7adns8	251	4	and	and	CC
cord-023168-cd7adns8	251	5	green	green	JJ
cord-023168-cd7adns8	251	6	leafy	leafy	JJ
cord-023168-cd7adns8	251	7	vegetables	vegetable	NNS
cord-023168-cd7adns8	251	8	,	,	,
cord-023168-cd7adns8	251	9	contain	contain	VBP
cord-023168-cd7adns8	251	10	non	non	JJ
cord-023168-cd7adns8	251	11	-	-	JJ
cord-023168-cd7adns8	251	12	haem	haem	JJ
cord-023168-cd7adns8	251	13	iron	iron	NN
cord-023168-cd7adns8	251	14	,	,	,
cord-023168-cd7adns8	251	15	which	which	WDT
cord-023168-cd7adns8	251	16	is	be	VBZ
cord-023168-cd7adns8	251	17	often	often	RB
cord-023168-cd7adns8	251	18	poorly	poorly	RB
cord-023168-cd7adns8	251	19	absorbed	absorb	VBN
cord-023168-cd7adns8	251	20	.	.	.
cord-023168-cd7adns8	252	1	If	if	IN
cord-023168-cd7adns8	252	2	dietary	dietary	JJ
cord-023168-cd7adns8	252	3	history	history	NN
cord-023168-cd7adns8	252	4	suggests	suggest	VBZ
cord-023168-cd7adns8	252	5	a	a	DT
cord-023168-cd7adns8	252	6	deficiency	deficiency	NN
cord-023168-cd7adns8	252	7	,	,	,
cord-023168-cd7adns8	252	8	diet	diet	NN
cord-023168-cd7adns8	252	9	with	with	IN
cord-023168-cd7adns8	252	10	foods	food	NNS
cord-023168-cd7adns8	252	11	rich	rich	JJ
cord-023168-cd7adns8	252	12	in	in	IN
cord-023168-cd7adns8	252	13	haem	haem	NN
cord-023168-cd7adns8	252	14	iron	iron	NN
cord-023168-cd7adns8	252	15	,	,	,
cord-023168-cd7adns8	252	16	such	such	JJ
cord-023168-cd7adns8	252	17	as	as	IN
cord-023168-cd7adns8	252	18	red	red	JJ
cord-023168-cd7adns8	252	19	meat	meat	NN
cord-023168-cd7adns8	252	20	or	or	CC
cord-023168-cd7adns8	252	21	liver	liver	NN
cord-023168-cd7adns8	252	22	should	should	MD
cord-023168-cd7adns8	252	23	be	be	VB
cord-023168-cd7adns8	252	24	recommended	recommend	VBN
cord-023168-cd7adns8	252	25	if	if	IN
cord-023168-cd7adns8	252	26	social	social	JJ
cord-023168-cd7adns8	252	27	and	and	CC
cord-023168-cd7adns8	252	28	religious	religious	JJ
cord-023168-cd7adns8	252	29	customs	custom	NNS
cord-023168-cd7adns8	252	30	and	and	CC
cord-023168-cd7adns8	252	31	financial	financial	JJ
cord-023168-cd7adns8	252	32	status	status	NN
cord-023168-cd7adns8	252	33	allow	allow	VBP
cord-023168-cd7adns8	252	34	,	,	,
cord-023168-cd7adns8	252	35	ideally	ideally	RB
cord-023168-cd7adns8	252	36	with	with	IN
cord-023168-cd7adns8	252	37	a	a	DT
cord-023168-cd7adns8	252	38	drink	drink	NN
cord-023168-cd7adns8	252	39	containing	contain	VBG
cord-023168-cd7adns8	252	40	vitamin	vitamin	NN
cord-023168-cd7adns8	252	41	C	c	NN
cord-023168-cd7adns8	252	42	to	to	TO
cord-023168-cd7adns8	252	43	facilitate	facilitate	VB
cord-023168-cd7adns8	252	44	iron	iron	NN
cord-023168-cd7adns8	252	45	absorption	absorption	NN
cord-023168-cd7adns8	252	46	.	.	.
cord-023168-cd7adns8	253	1	Absorption	absorption	NN
cord-023168-cd7adns8	253	2	is	be	VBZ
cord-023168-cd7adns8	253	3	also	also	RB
cord-023168-cd7adns8	253	4	facilitated	facilitate	VBN
cord-023168-cd7adns8	253	5	by	by	IN
cord-023168-cd7adns8	253	6	taking	take	VBG
cord-023168-cd7adns8	253	7	supplements	supplement	NNS
cord-023168-cd7adns8	253	8	on	on	IN
cord-023168-cd7adns8	253	9	an	an	DT
cord-023168-cd7adns8	253	10	empty	empty	JJ
cord-023168-cd7adns8	253	11	stomach	stomach	NN
cord-023168-cd7adns8	253	12	although	although	IN
cord-023168-cd7adns8	253	13	side	side	JJ
cord-023168-cd7adns8	253	14	effects	effect	NNS
cord-023168-cd7adns8	253	15	of	of	IN
cord-023168-cd7adns8	253	16	dyspepsia	dyspepsia	NN
cord-023168-cd7adns8	253	17	may	may	MD
cord-023168-cd7adns8	253	18	not	not	RB
cord-023168-cd7adns8	253	19	always	always	RB
cord-023168-cd7adns8	253	20	allow	allow	VB
cord-023168-cd7adns8	253	21	this	this	DT
cord-023168-cd7adns8	253	22	strategy	strategy	NN
cord-023168-cd7adns8	253	23	.	.	.
cord-023168-cd7adns8	254	1	Heavy	heavy	JJ
cord-023168-cd7adns8	254	2	tea	tea	NN
cord-023168-cd7adns8	254	3	intake	intake	NN
cord-023168-cd7adns8	254	4	can	can	MD
cord-023168-cd7adns8	254	5	interfere	interfere	VB
cord-023168-cd7adns8	254	6	with	with	IN
cord-023168-cd7adns8	254	7	iron	iron	NN
cord-023168-cd7adns8	254	8	absorption	absorption	NN
cord-023168-cd7adns8	254	9	and	and	CC
cord-023168-cd7adns8	254	10	should	should	MD
cord-023168-cd7adns8	254	11	be	be	VB
cord-023168-cd7adns8	254	12	avoided	avoid	VBN
cord-023168-cd7adns8	254	13	.	.	.
cord-023168-cd7adns8	255	1	Multivitamin	multivitamin	NN
cord-023168-cd7adns8	255	2	or	or	CC
cord-023168-cd7adns8	255	3	dietary	dietary	JJ
cord-023168-cd7adns8	255	4	supplements	supplement	NNS
cord-023168-cd7adns8	255	5	containing	contain	VBG
cord-023168-cd7adns8	255	6	calcium	calcium	NN
cord-023168-cd7adns8	255	7	,	,	,
cord-023168-cd7adns8	255	8	zinc	zinc	NN
cord-023168-cd7adns8	255	9	or	or	CC
cord-023168-cd7adns8	255	10	copper	copper	NN
cord-023168-cd7adns8	255	11	can	can	MD
cord-023168-cd7adns8	255	12	also	also	RB
cord-023168-cd7adns8	255	13	interfere	interfere	VB
cord-023168-cd7adns8	255	14	with	with	IN
cord-023168-cd7adns8	255	15	iron	iron	NN
cord-023168-cd7adns8	255	16	absorption	absorption	NN
cord-023168-cd7adns8	255	17	.	.	.
cord-023168-cd7adns8	256	1	Absorption	absorption	NN
cord-023168-cd7adns8	256	2	may	may	MD
cord-023168-cd7adns8	256	3	be	be	VB
cord-023168-cd7adns8	256	4	delayed	delay	VBN
cord-023168-cd7adns8	256	5	by	by	IN
cord-023168-cd7adns8	256	6	tetracyclines	tetracycline	NNS
cord-023168-cd7adns8	256	7	,	,	,
cord-023168-cd7adns8	256	8	milk	milk	NN
cord-023168-cd7adns8	256	9	and	and	CC
cord-023168-cd7adns8	256	10	soft	soft	JJ
cord-023168-cd7adns8	256	11	drinks	drink	NNS
cord-023168-cd7adns8	256	12	.	.	.
cord-023168-cd7adns8	257	1	Since	since	IN
cord-023168-cd7adns8	257	2	acid	acid	NN
cord-023168-cd7adns8	257	3	is	be	VBZ
cord-023168-cd7adns8	257	4	necessary	necessary	JJ
cord-023168-cd7adns8	257	5	for	for	IN
cord-023168-cd7adns8	257	6	iron	iron	NN
cord-023168-cd7adns8	257	7	absorption	absorption	NN
cord-023168-cd7adns8	257	8	,	,	,
cord-023168-cd7adns8	257	9	antacids	antacid	NNS
cord-023168-cd7adns8	257	10	may	may	MD
cord-023168-cd7adns8	257	11	account	account	VB
cord-023168-cd7adns8	257	12	for	for	IN
cord-023168-cd7adns8	257	13	a	a	DT
cord-023168-cd7adns8	257	14	poor	poor	JJ
cord-023168-cd7adns8	257	15	response	response	NN
cord-023168-cd7adns8	257	16	to	to	IN
cord-023168-cd7adns8	257	17	oral	oral	JJ
cord-023168-cd7adns8	257	18	iron	iron	NN
cord-023168-cd7adns8	257	19	.	.	.
cord-023168-cd7adns8	258	1	Iron	iron	NN
cord-023168-cd7adns8	258	2	is	be	VBZ
cord-023168-cd7adns8	258	3	usually	usually	RB
cord-023168-cd7adns8	258	4	prescribed	prescribe	VBN
cord-023168-cd7adns8	258	5	as	as	IN
cord-023168-cd7adns8	258	6	a	a	DT
cord-023168-cd7adns8	258	7	daily	daily	JJ
cord-023168-cd7adns8	258	8	dose	dose	NN
cord-023168-cd7adns8	258	9	of	of	IN
cord-023168-cd7adns8	258	10	150	150	CD
cord-023168-cd7adns8	258	11	-	-	SYM
cord-023168-cd7adns8	258	12	200	200	CD
cord-023168-cd7adns8	258	13	mg	mg	NNS
cord-023168-cd7adns8	258	14	of	of	IN
cord-023168-cd7adns8	258	15	elemental	elemental	JJ
cord-023168-cd7adns8	258	16	iron	iron	NN
cord-023168-cd7adns8	258	17	,	,	,
cord-023168-cd7adns8	258	18	commonly	commonly	RB
cord-023168-cd7adns8	258	19	ferrous	ferrous	JJ
cord-023168-cd7adns8	258	20	sulphate	sulphate	NN
cord-023168-cd7adns8	258	21	,	,	,
cord-023168-cd7adns8	258	22	1	1	CD
cord-023168-cd7adns8	258	23	tablet	tablet	NN
cord-023168-cd7adns8	258	24	three	three	CD
cord-023168-cd7adns8	258	25	times	time	NNS
cord-023168-cd7adns8	258	26	daily	daily	RB
cord-023168-cd7adns8	258	27	.	.	.
cord-023168-cd7adns8	259	1	The	the	DT
cord-023168-cd7adns8	259	2	dose	dose	NN
cord-023168-cd7adns8	259	3	in	in	IN
cord-023168-cd7adns8	259	4	children	child	NNS
cord-023168-cd7adns8	259	5	is	be	VBZ
cord-023168-cd7adns8	259	6	3	3	CD
cord-023168-cd7adns8	259	7	-	-	SYM
cord-023168-cd7adns8	259	8	6	6	CD
cord-023168-cd7adns8	259	9	mg	mg	NNP
cord-023168-cd7adns8	259	10	/	/	SYM
cord-023168-cd7adns8	259	11	kg	kg	NN
cord-023168-cd7adns8	259	12	per	per	IN
cord-023168-cd7adns8	259	13	day	day	NN
cord-023168-cd7adns8	259	14	split	split	NN
cord-023168-cd7adns8	259	15	into	into	IN
cord-023168-cd7adns8	259	16	divided	divide	VBN
cord-023168-cd7adns8	259	17	doses	dose	NNS
cord-023168-cd7adns8	259	18	.	.	.
cord-023168-cd7adns8	260	1	Assuming	assume	VBG
cord-023168-cd7adns8	260	2	good	good	JJ
cord-023168-cd7adns8	260	3	compliance	compliance	NN
cord-023168-cd7adns8	260	4	and	and	CC
cord-023168-cd7adns8	260	5	absorption	absorption	NN
cord-023168-cd7adns8	260	6	,	,	,
cord-023168-cd7adns8	260	7	this	this	DT
cord-023168-cd7adns8	260	8	should	should	MD
cord-023168-cd7adns8	260	9	result	result	VB
cord-023168-cd7adns8	260	10	in	in	IN
cord-023168-cd7adns8	260	11	an	an	DT
cord-023168-cd7adns8	260	12	increase	increase	NN
cord-023168-cd7adns8	260	13	in	in	IN
cord-023168-cd7adns8	260	14	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	260	15	within	within	IN
cord-023168-cd7adns8	260	16	4	4	CD
cord-023168-cd7adns8	260	17	weeks	week	NNS
cord-023168-cd7adns8	260	18	.	.	.
cord-023168-cd7adns8	261	1	Once	once	IN
cord-023168-cd7adns8	261	2	the	the	DT
cord-023168-cd7adns8	261	3	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	261	4	is	be	VBZ
cord-023168-cd7adns8	261	5	normalized	normalize	VBN
cord-023168-cd7adns8	261	6	,	,	,
cord-023168-cd7adns8	261	7	iron	iron	NN
cord-023168-cd7adns8	261	8	should	should	MD
cord-023168-cd7adns8	261	9	be	be	VB
cord-023168-cd7adns8	261	10	continued	continue	VBN
cord-023168-cd7adns8	261	11	for	for	IN
cord-023168-cd7adns8	261	12	3	3	CD
cord-023168-cd7adns8	261	13	months	month	NNS
cord-023168-cd7adns8	261	14	to	to	TO
cord-023168-cd7adns8	261	15	replenish	replenish	VB
cord-023168-cd7adns8	261	16	the	the	DT
cord-023168-cd7adns8	261	17	iron	iron	NN
cord-023168-cd7adns8	261	18	stores	store	NNS
cord-023168-cd7adns8	261	19	.	.	.
cord-023168-cd7adns8	262	1	The	the	DT
cord-023168-cd7adns8	262	2	major	major	JJ
cord-023168-cd7adns8	262	3	problem	problem	NN
cord-023168-cd7adns8	262	4	with	with	IN
cord-023168-cd7adns8	262	5	oral	oral	JJ
cord-023168-cd7adns8	262	6	iron	iron	NN
cord-023168-cd7adns8	262	7	is	be	VBZ
cord-023168-cd7adns8	262	8	upper	upper	JJ
cord-023168-cd7adns8	262	9	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	262	10	side	side	NN
cord-023168-cd7adns8	262	11	-	-	HYPH
cord-023168-cd7adns8	262	12	effects	effect	NNS
cord-023168-cd7adns8	262	13	,	,	,
cord-023168-cd7adns8	262	14	which	which	WDT
cord-023168-cd7adns8	262	15	can	can	MD
cord-023168-cd7adns8	262	16	be	be	VB
cord-023168-cd7adns8	262	17	dose	dose	NN
cord-023168-cd7adns8	262	18	-	-	HYPH
cord-023168-cd7adns8	262	19	dependent	dependent	JJ
cord-023168-cd7adns8	262	20	.	.	.
cord-023168-cd7adns8	263	1	A	a	DT
cord-023168-cd7adns8	263	2	reduction	reduction	NN
cord-023168-cd7adns8	263	3	in	in	IN
cord-023168-cd7adns8	263	4	the	the	DT
cord-023168-cd7adns8	263	5	dose	dose	NN
cord-023168-cd7adns8	263	6	or	or	CC
cord-023168-cd7adns8	263	7	change	change	NN
cord-023168-cd7adns8	263	8	in	in	IN
cord-023168-cd7adns8	263	9	the	the	DT
cord-023168-cd7adns8	263	10	formulation	formulation	NN
cord-023168-cd7adns8	263	11	to	to	TO
cord-023168-cd7adns8	263	12	gluconate	gluconate	VB
cord-023168-cd7adns8	263	13	or	or	CC
cord-023168-cd7adns8	263	14	fumarate	fumarate	NN
cord-023168-cd7adns8	263	15	or	or	CC
cord-023168-cd7adns8	263	16	even	even	RB
cord-023168-cd7adns8	263	17	liquid	liquid	JJ
cord-023168-cd7adns8	263	18	forms	form	NNS
cord-023168-cd7adns8	263	19	,	,	,
cord-023168-cd7adns8	263	20	may	may	MD
cord-023168-cd7adns8	263	21	be	be	VB
cord-023168-cd7adns8	263	22	successful	successful	JJ
cord-023168-cd7adns8	263	23	.	.	.
cord-023168-cd7adns8	264	1	Liquid	liquid	JJ
cord-023168-cd7adns8	264	2	iron	iron	NN
cord-023168-cd7adns8	264	3	preparations	preparation	NNS
cord-023168-cd7adns8	264	4	may	may	MD
cord-023168-cd7adns8	264	5	stain	stain	VB
cord-023168-cd7adns8	264	6	the	the	DT
cord-023168-cd7adns8	264	7	teeth	tooth	NNS
cord-023168-cd7adns8	264	8	and	and	CC
cord-023168-cd7adns8	264	9	should	should	MD
cord-023168-cd7adns8	264	10	therefore	therefore	RB
cord-023168-cd7adns8	264	11	be	be	VB
cord-023168-cd7adns8	264	12	taken	take	VBN
cord-023168-cd7adns8	264	13	through	through	IN
cord-023168-cd7adns8	264	14	a	a	DT
cord-023168-cd7adns8	264	15	straw	straw	NN
cord-023168-cd7adns8	264	16	.	.	.
cord-023168-cd7adns8	265	1	Oral	oral	JJ
cord-023168-cd7adns8	265	2	iron	iron	NN
cord-023168-cd7adns8	265	3	can	can	MD
cord-023168-cd7adns8	265	4	also	also	RB
cord-023168-cd7adns8	265	5	cause	cause	VB
cord-023168-cd7adns8	265	6	constipation	constipation	NN
cord-023168-cd7adns8	265	7	or	or	CC
cord-023168-cd7adns8	265	8	diarrhoea	diarrhoea	NN
cord-023168-cd7adns8	265	9	which	which	WDT
cord-023168-cd7adns8	265	10	is	be	VBZ
cord-023168-cd7adns8	265	11	not	not	RB
cord-023168-cd7adns8	265	12	dose	dose	NN
cord-023168-cd7adns8	265	13	-	-	HYPH
cord-023168-cd7adns8	265	14	dependent	dependent	JJ
cord-023168-cd7adns8	265	15	.	.	.
cord-023168-cd7adns8	266	1	Parenteral	parenteral	JJ
cord-023168-cd7adns8	266	2	iron	iron	NN
cord-023168-cd7adns8	266	3	is	be	VBZ
cord-023168-cd7adns8	266	4	best	well	RBS
cord-023168-cd7adns8	266	5	given	give	VBN
cord-023168-cd7adns8	266	6	intravenously	intravenously	RB
cord-023168-cd7adns8	266	7	because	because	IN
cord-023168-cd7adns8	266	8	intramuscular	intramuscular	JJ
cord-023168-cd7adns8	266	9	iron	iron	NN
cord-023168-cd7adns8	266	10	is	be	VBZ
cord-023168-cd7adns8	266	11	painful	painful	JJ
cord-023168-cd7adns8	266	12	and	and	CC
cord-023168-cd7adns8	266	13	has	have	VBZ
cord-023168-cd7adns8	266	14	been	be	VBN
cord-023168-cd7adns8	266	15	associated	associate	VBN
cord-023168-cd7adns8	266	16	with	with	IN
cord-023168-cd7adns8	266	17	development	development	NN
cord-023168-cd7adns8	266	18	of	of	IN
cord-023168-cd7adns8	266	19	soft	soft	JJ
cord-023168-cd7adns8	266	20	tissue	tissue	NN
cord-023168-cd7adns8	266	21	sarcomas	sarcoma	NNS
cord-023168-cd7adns8	266	22	.	.	.
cord-023168-cd7adns8	267	1	32	32	CD
cord-023168-cd7adns8	267	2	High	high	JJ
cord-023168-cd7adns8	267	3	-	-	HYPH
cord-023168-cd7adns8	267	4	molecular	molecular	JJ
cord-023168-cd7adns8	267	5	-	-	HYPH
cord-023168-cd7adns8	267	6	weight	weight	NN
cord-023168-cd7adns8	267	7	iron	iron	NN
cord-023168-cd7adns8	267	8	dextran	dextran	NN
cord-023168-cd7adns8	267	9	carries	carry	VBZ
cord-023168-cd7adns8	267	10	a	a	DT
cord-023168-cd7adns8	267	11	low	low	JJ
cord-023168-cd7adns8	267	12	but	but	CC
cord-023168-cd7adns8	267	13	significant	significant	JJ
cord-023168-cd7adns8	267	14	risk	risk	NN
cord-023168-cd7adns8	267	15	of	of	IN
cord-023168-cd7adns8	267	16	anaphylaxis	anaphylaxis	NN
cord-023168-cd7adns8	267	17	,	,	,
cord-023168-cd7adns8	267	18	but	but	CC
cord-023168-cd7adns8	267	19	the	the	DT
cord-023168-cd7adns8	267	20	newer	new	JJR
cord-023168-cd7adns8	267	21	formulations	formulation	NNS
cord-023168-cd7adns8	267	22	including	include	VBG
cord-023168-cd7adns8	267	23	low	low	JJ
cord-023168-cd7adns8	267	24	-	-	HYPH
cord-023168-cd7adns8	267	25	molecular	molecular	JJ
cord-023168-cd7adns8	267	26	-	-	HYPH
cord-023168-cd7adns8	267	27	weight	weight	NN
cord-023168-cd7adns8	267	28	iron	iron	NN
cord-023168-cd7adns8	267	29	dextran	dextran	NN
cord-023168-cd7adns8	267	30	,	,	,
cord-023168-cd7adns8	267	31	iron	iron	NN
cord-023168-cd7adns8	267	32	sucrose	sucrose	NN
cord-023168-cd7adns8	267	33	,	,	,
cord-023168-cd7adns8	267	34	ferumoxytol	ferumoxytol	NN
cord-023168-cd7adns8	267	35	and	and	CC
cord-023168-cd7adns8	267	36	iron	iron	NN
cord-023168-cd7adns8	267	37	gluconate	gluconate	NN
cord-023168-cd7adns8	267	38	have	have	VBP
cord-023168-cd7adns8	267	39	minimal	minimal	JJ
cord-023168-cd7adns8	267	40	risks	risk	NNS
cord-023168-cd7adns8	267	41	.	.	.
cord-023168-cd7adns8	268	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	268	2	B	b	NN
cord-023168-cd7adns8	268	3	12	12	CD
cord-023168-cd7adns8	268	4	or	or	CC
cord-023168-cd7adns8	268	5	cobalamin	cobalamin	JJ
cord-023168-cd7adns8	268	6	deficiency	deficiency	NN
cord-023168-cd7adns8	268	7	is	be	VBZ
cord-023168-cd7adns8	268	8	a	a	DT
cord-023168-cd7adns8	268	9	well	well	RB
cord-023168-cd7adns8	268	10	-	-	HYPH
cord-023168-cd7adns8	268	11	recognized	recognize	VBN
cord-023168-cd7adns8	268	12	cause	cause	NN
cord-023168-cd7adns8	268	13	of	of	IN
cord-023168-cd7adns8	268	14	macrocytic	macrocytic	JJ
cord-023168-cd7adns8	268	15	anaemia	anaemia	NN
cord-023168-cd7adns8	268	16	(	(	-LRB-
cord-023168-cd7adns8	268	17	Box	Box	NNP
cord-023168-cd7adns8	268	18	65.5	65.5	CD
cord-023168-cd7adns8	268	19	)	)	-RRB-
cord-023168-cd7adns8	268	20	.	.	.
cord-023168-cd7adns8	269	1	Although	although	IN
cord-023168-cd7adns8	269	2	some	some	DT
cord-023168-cd7adns8	269	3	microorganisms	microorganism	NNS
cord-023168-cd7adns8	269	4	can	can	MD
cord-023168-cd7adns8	269	5	synthesize	synthesize	VB
cord-023168-cd7adns8	269	6	cobalamin	cobalamin	NN
cord-023168-cd7adns8	269	7	,	,	,
cord-023168-cd7adns8	269	8	humans	human	NNS
cord-023168-cd7adns8	269	9	need	need	VBP
cord-023168-cd7adns8	269	10	to	to	TO
cord-023168-cd7adns8	269	11	obtain	obtain	VB
cord-023168-cd7adns8	269	12	this	this	DT
cord-023168-cd7adns8	269	13	essential	essential	JJ
cord-023168-cd7adns8	269	14	vitamin	vitamin	NN
cord-023168-cd7adns8	269	15	from	from	IN
cord-023168-cd7adns8	269	16	foods	food	NNS
cord-023168-cd7adns8	269	17	,	,	,
cord-023168-cd7adns8	269	18	mainly	mainly	RB
cord-023168-cd7adns8	269	19	meat	meat	NN
cord-023168-cd7adns8	269	20	,	,	,
cord-023168-cd7adns8	269	21	poultry	poultry	NN
cord-023168-cd7adns8	269	22	and	and	CC
cord-023168-cd7adns8	269	23	dairy	dairy	NN
cord-023168-cd7adns8	269	24	products	product	NNS
cord-023168-cd7adns8	269	25	.	.	.
cord-023168-cd7adns8	270	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	270	2	B	B	NNP
cord-023168-cd7adns8	270	3	12	12	CD
cord-023168-cd7adns8	270	4	is	be	VBZ
cord-023168-cd7adns8	270	5	an	an	DT
cord-023168-cd7adns8	270	6	essential	essential	JJ
cord-023168-cd7adns8	270	7	co	co	NN
cord-023168-cd7adns8	270	8	-	-	NN
cord-023168-cd7adns8	270	9	factor	factor	NN
cord-023168-cd7adns8	270	10	in	in	IN
cord-023168-cd7adns8	270	11	DNA	dna	NN
cord-023168-cd7adns8	270	12	synthesis	synthesis	NN
cord-023168-cd7adns8	270	13	,	,	,
cord-023168-cd7adns8	270	14	serving	serve	VBG
cord-023168-cd7adns8	270	15	as	as	IN
cord-023168-cd7adns8	270	16	a	a	DT
cord-023168-cd7adns8	270	17	co	co	NN
cord-023168-cd7adns8	270	18	-	-	NN
cord-023168-cd7adns8	270	19	factor	factor	NN
cord-023168-cd7adns8	270	20	in	in	IN
cord-023168-cd7adns8	270	21	two	two	CD
cord-023168-cd7adns8	270	22	key	key	JJ
cord-023168-cd7adns8	270	23	biochemical	biochemical	JJ
cord-023168-cd7adns8	270	24	processes	process	NNS
cord-023168-cd7adns8	270	25	involving	involve	VBG
cord-023168-cd7adns8	270	26	methylmalonic	methylmalonic	NNP
cord-023168-cd7adns8	270	27	acid	acid	NN
cord-023168-cd7adns8	270	28	and	and	CC
cord-023168-cd7adns8	270	29	homocysteine	homocysteine	NN
cord-023168-cd7adns8	270	30	as	as	IN
cord-023168-cd7adns8	270	31	precursors	precursor	NNS
cord-023168-cd7adns8	270	32	.	.	.
cord-023168-cd7adns8	271	1	Consequently	consequently	RB
cord-023168-cd7adns8	271	2	vitamin	vitamin	NN
cord-023168-cd7adns8	271	3	B	b	NN
cord-023168-cd7adns8	271	4	12	12	CD
cord-023168-cd7adns8	271	5	deficiency	deficiency	NN
cord-023168-cd7adns8	271	6	can	can	MD
cord-023168-cd7adns8	271	7	interfere	interfere	VB
cord-023168-cd7adns8	271	8	with	with	IN
cord-023168-cd7adns8	271	9	DNA	dna	NN
cord-023168-cd7adns8	271	10	synthesis	synthesis	NN
cord-023168-cd7adns8	271	11	.	.	.
cord-023168-cd7adns8	272	1	Clinical	clinical	JJ
cord-023168-cd7adns8	272	2	manifestations	manifestation	NNS
cord-023168-cd7adns8	272	3	include	include	VBP
cord-023168-cd7adns8	272	4	haematological	haematological	JJ
cord-023168-cd7adns8	272	5	(	(	-LRB-
cord-023168-cd7adns8	272	6	megaloblastic	megaloblastic	JJ
cord-023168-cd7adns8	272	7	anaemia	anaemia	NN
cord-023168-cd7adns8	272	8	and	and	CC
cord-023168-cd7adns8	272	9	pancytopenia	pancytopenia	NNP
cord-023168-cd7adns8	272	10	)	)	-RRB-
cord-023168-cd7adns8	272	11	,	,	,
cord-023168-cd7adns8	272	12	and	and	CC
cord-023168-cd7adns8	272	13	neuropsychiatric	neuropsychiatric	JJ
cord-023168-cd7adns8	272	14	disorders	disorder	NNS
cord-023168-cd7adns8	272	15	(	(	-LRB-
cord-023168-cd7adns8	272	16	paraesthesia	paraesthesia	NNP
cord-023168-cd7adns8	272	17	,	,	,
cord-023168-cd7adns8	272	18	peripheral	peripheral	JJ
cord-023168-cd7adns8	272	19	neuropathy	neuropathy	NN
cord-023168-cd7adns8	272	20	,	,	,
cord-023168-cd7adns8	272	21	psychosis	psychosis	NN
cord-023168-cd7adns8	272	22	and	and	CC
cord-023168-cd7adns8	272	23	dementia	dementia	NN
cord-023168-cd7adns8	272	24	)	)	-RRB-
cord-023168-cd7adns8	272	25	and	and	CC
cord-023168-cd7adns8	272	26	an	an	DT
cord-023168-cd7adns8	272	27	increased	increase	VBN
cord-023168-cd7adns8	272	28	risk	risk	NN
cord-023168-cd7adns8	272	29	of	of	IN
cord-023168-cd7adns8	272	30	cardiovascular	cardiovascular	JJ
cord-023168-cd7adns8	272	31	disease	disease	NN
cord-023168-cd7adns8	272	32	because	because	IN
cord-023168-cd7adns8	272	33	of	of	IN
cord-023168-cd7adns8	272	34	hyperhomocystinaemia	hyperhomocystinaemia	NNP
cord-023168-cd7adns8	272	35	.	.	.
cord-023168-cd7adns8	273	1	[	[	-LRB-
cord-023168-cd7adns8	273	2	32	32	CD
cord-023168-cd7adns8	273	3	]	]	-RRB-
cord-023168-cd7adns8	273	4	[	[	-LRB-
cord-023168-cd7adns8	273	5	33	33	CD
cord-023168-cd7adns8	273	6	]	]	-RRB-
cord-023168-cd7adns8	273	7	[	[	-LRB-
cord-023168-cd7adns8	273	8	34	34	CD
cord-023168-cd7adns8	273	9	]	]	-RRB-
cord-023168-cd7adns8	273	10	A	a	DT
cord-023168-cd7adns8	273	11	systematic	systematic	JJ
cord-023168-cd7adns8	273	12	approach	approach	NN
cord-023168-cd7adns8	273	13	to	to	IN
cord-023168-cd7adns8	273	14	the	the	DT
cord-023168-cd7adns8	273	15	investigation	investigation	NN
cord-023168-cd7adns8	273	16	of	of	IN
cord-023168-cd7adns8	273	17	vitamin	vitamin	NN
cord-023168-cd7adns8	273	18	B	b	NN
cord-023168-cd7adns8	273	19	12	12	CD
cord-023168-cd7adns8	273	20	deficiency	deficiency	NN
cord-023168-cd7adns8	273	21	requires	require	VBZ
cord-023168-cd7adns8	273	22	an	an	DT
cord-023168-cd7adns8	273	23	understanding	understanding	NN
cord-023168-cd7adns8	273	24	of	of	IN
cord-023168-cd7adns8	273	25	the	the	DT
cord-023168-cd7adns8	273	26	absorption	absorption	NN
cord-023168-cd7adns8	273	27	cycle	cycle	NN
cord-023168-cd7adns8	273	28	.	.	.
cord-023168-cd7adns8	274	1	35	35	CD
cord-023168-cd7adns8	275	1	Ingested	ingested	JJ
cord-023168-cd7adns8	275	2	vitamin	vitamin	NN
cord-023168-cd7adns8	275	3	B	b	NN
cord-023168-cd7adns8	275	4	12	12	CD
cord-023168-cd7adns8	275	5	is	be	VBZ
cord-023168-cd7adns8	275	6	broken	break	VBN
cord-023168-cd7adns8	275	7	down	down	RP
cord-023168-cd7adns8	275	8	in	in	IN
cord-023168-cd7adns8	275	9	the	the	DT
cord-023168-cd7adns8	275	10	acidic	acidic	JJ
cord-023168-cd7adns8	275	11	environment	environment	NN
cord-023168-cd7adns8	275	12	of	of	IN
cord-023168-cd7adns8	275	13	the	the	DT
cord-023168-cd7adns8	275	14	stomach	stomach	NN
cord-023168-cd7adns8	275	15	.	.	.
cord-023168-cd7adns8	276	1	It	-PRON-	PRP
cord-023168-cd7adns8	276	2	binds	bind	VBZ
cord-023168-cd7adns8	276	3	to	to	IN
cord-023168-cd7adns8	276	4	R	r	NN
cord-023168-cd7adns8	276	5	-	-	HYPH
cord-023168-cd7adns8	276	6	binders	binder	NNS
cord-023168-cd7adns8	276	7	in	in	IN
cord-023168-cd7adns8	276	8	gastric	gastric	JJ
cord-023168-cd7adns8	276	9	secretions	secretion	NNS
cord-023168-cd7adns8	276	10	and	and	CC
cord-023168-cd7adns8	276	11	saliva	saliva	NN
cord-023168-cd7adns8	276	12	which	which	WDT
cord-023168-cd7adns8	276	13	stabilize	stabilize	VBP
cord-023168-cd7adns8	276	14	the	the	DT
cord-023168-cd7adns8	276	15	vitamin	vitamin	NN
cord-023168-cd7adns8	276	16	B	b	NN
cord-023168-cd7adns8	276	17	12	12	CD
cord-023168-cd7adns8	276	18	.	.	.
cord-023168-cd7adns8	277	1	In	in	IN
cord-023168-cd7adns8	277	2	the	the	DT
cord-023168-cd7adns8	277	3	alkaline	alkaline	JJ
cord-023168-cd7adns8	277	4	environment	environment	NN
cord-023168-cd7adns8	277	5	of	of	IN
cord-023168-cd7adns8	277	6	the	the	DT
cord-023168-cd7adns8	277	7	small	small	JJ
cord-023168-cd7adns8	277	8	intestine	intestine	NN
cord-023168-cd7adns8	277	9	,	,	,
cord-023168-cd7adns8	277	10	vitamin	vitamin	NN
cord-023168-cd7adns8	277	11	B	b	NN
cord-023168-cd7adns8	277	12	12	12	CD
cord-023168-cd7adns8	277	13	is	be	VBZ
cord-023168-cd7adns8	277	14	released	release	VBN
cord-023168-cd7adns8	277	15	from	from	IN
cord-023168-cd7adns8	277	16	R	r	NN
cord-023168-cd7adns8	277	17	-	-	HYPH
cord-023168-cd7adns8	277	18	binders	binder	NNS
cord-023168-cd7adns8	277	19	to	to	TO
cord-023168-cd7adns8	277	20	bind	bind	VB
cord-023168-cd7adns8	277	21	to	to	IN
cord-023168-cd7adns8	277	22	intrinsic	intrinsic	JJ
cord-023168-cd7adns8	277	23	factor	factor	NN
cord-023168-cd7adns8	277	24	,	,	,
cord-023168-cd7adns8	277	25	synthesized	synthesize	VBN
cord-023168-cd7adns8	277	26	in	in	IN
cord-023168-cd7adns8	277	27	the	the	DT
cord-023168-cd7adns8	277	28	gastric	gastric	JJ
cord-023168-cd7adns8	277	29	parietal	parietal	JJ
cord-023168-cd7adns8	277	30	cells	cell	NNS
cord-023168-cd7adns8	277	31	.	.	.
cord-023168-cd7adns8	278	1	This	this	DT
cord-023168-cd7adns8	278	2	vitamin	vitamin	NN
cord-023168-cd7adns8	278	3	B	b	NN
cord-023168-cd7adns8	278	4	12	12	CD
cord-023168-cd7adns8	278	5	-intrinsic	-intrinsic	NN
cord-023168-cd7adns8	278	6	factor	factor	NN
cord-023168-cd7adns8	278	7	complex	complex	NN
cord-023168-cd7adns8	278	8	is	be	VBZ
cord-023168-cd7adns8	278	9	absorbed	absorb	VBN
cord-023168-cd7adns8	278	10	from	from	IN
cord-023168-cd7adns8	278	11	the	the	DT
cord-023168-cd7adns8	278	12	terminal	terminal	JJ
cord-023168-cd7adns8	278	13	ileum	ileum	NN
cord-023168-cd7adns8	278	14	.	.	.
cord-023168-cd7adns8	279	1	Recently	recently	RB
cord-023168-cd7adns8	279	2	,	,	,
cord-023168-cd7adns8	279	3	an	an	DT
cord-023168-cd7adns8	279	4	alternative	alternative	JJ
cord-023168-cd7adns8	279	5	absorption	absorption	NN
cord-023168-cd7adns8	279	6	system	system	NN
cord-023168-cd7adns8	279	7	independent	independent	JJ
cord-023168-cd7adns8	279	8	of	of	IN
cord-023168-cd7adns8	279	9	intrinsic	intrinsic	JJ
cord-023168-cd7adns8	279	10	factor	factor	NN
cord-023168-cd7adns8	279	11	and	and	CC
cord-023168-cd7adns8	279	12	the	the	DT
cord-023168-cd7adns8	279	13	terminal	terminal	JJ
cord-023168-cd7adns8	279	14	ileum	ileum	NN
cord-023168-cd7adns8	279	15	has	have	VBZ
cord-023168-cd7adns8	279	16	been	be	VBN
cord-023168-cd7adns8	279	17	postulated	postulate	VBN
cord-023168-cd7adns8	279	18	which	which	WDT
cord-023168-cd7adns8	279	19	provides	provide	VBZ
cord-023168-cd7adns8	279	20	a	a	DT
cord-023168-cd7adns8	279	21	rationale	rationale	NN
cord-023168-cd7adns8	279	22	for	for	IN
cord-023168-cd7adns8	279	23	Mean	mean	JJ
cord-023168-cd7adns8	279	24	cell	cell	NN
cord-023168-cd7adns8	279	25	volume	volume	NN
cord-023168-cd7adns8	279	26	Useful	useful	JJ
cord-023168-cd7adns8	279	27	as	as	IN
cord-023168-cd7adns8	279	28	a	a	DT
cord-023168-cd7adns8	279	29	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	279	30	clue	clue	NN
cord-023168-cd7adns8	279	31	but	but	CC
cord-023168-cd7adns8	279	32	not	not	RB
cord-023168-cd7adns8	279	33	confirmatory	confirmatory	JJ
cord-023168-cd7adns8	279	34	Can	Can	MD
cord-023168-cd7adns8	279	35	also	also	RB
cord-023168-cd7adns8	279	36	be	be	VB
cord-023168-cd7adns8	279	37	low	low	JJ
cord-023168-cd7adns8	279	38	in	in	IN
cord-023168-cd7adns8	279	39	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	279	40	,	,	,
cord-023168-cd7adns8	279	41	sideroblastic	sideroblastic	JJ
cord-023168-cd7adns8	279	42	anaemia	anaemia	NN
cord-023168-cd7adns8	279	43	and	and	CC
cord-023168-cd7adns8	279	44	rarely	rarely	RB
cord-023168-cd7adns8	279	45	lead	lead	VBP
cord-023168-cd7adns8	279	46	poisoning	poisoning	NN
cord-023168-cd7adns8	279	47	Can	Can	MD
cord-023168-cd7adns8	279	48	be	be	VB
cord-023168-cd7adns8	279	49	falsely	falsely	RB
cord-023168-cd7adns8	279	50	normal	normal	JJ
cord-023168-cd7adns8	279	51	in	in	IN
cord-023168-cd7adns8	279	52	the	the	DT
cord-023168-cd7adns8	279	53	presence	presence	NN
cord-023168-cd7adns8	279	54	of	of	IN
cord-023168-cd7adns8	279	55	iron	iron	NN
cord-023168-cd7adns8	279	56	deficiency	deficiency	NN
cord-023168-cd7adns8	279	57	in	in	IN
cord-023168-cd7adns8	279	58	older	old	JJR
cord-023168-cd7adns8	279	59	people	people	NNS
cord-023168-cd7adns8	279	60	or	or	CC
cord-023168-cd7adns8	279	61	with	with	IN
cord-023168-cd7adns8	279	62	coexistent	coexistent	JJ
cord-023168-cd7adns8	279	63	megaloblastic	megaloblastic	JJ
cord-023168-cd7adns8	279	64	anaemia	anaemia	NN
cord-023168-cd7adns8	279	65	Anaemia	anaemia	NN
cord-023168-cd7adns8	279	66	of	of	IN
cord-023168-cd7adns8	279	67	chronic	chronic	JJ
cord-023168-cd7adns8	279	68	disease	disease	NN
cord-023168-cd7adns8	279	69	can	can	MD
cord-023168-cd7adns8	279	70	occasionally	occasionally	RB
cord-023168-cd7adns8	279	71	cause	cause	VB
cord-023168-cd7adns8	279	72	microcytosis	microcytosis	NNP
cord-023168-cd7adns8	279	73	Serum	serum	NN
cord-023168-cd7adns8	279	74	ferritin	ferritin	NN
cord-023168-cd7adns8	280	1	The	the	DT
cord-023168-cd7adns8	280	2	most	most	RBS
cord-023168-cd7adns8	280	3	useful	useful	JJ
cord-023168-cd7adns8	280	4	laboratory	laboratory	NN
cord-023168-cd7adns8	280	5	measure	measure	NN
cord-023168-cd7adns8	280	6	of	of	IN
cord-023168-cd7adns8	280	7	iron	iron	NN
cord-023168-cd7adns8	280	8	status	status	NN
cord-023168-cd7adns8	280	9	Low	low	JJ
cord-023168-cd7adns8	280	10	value	value	NN
cord-023168-cd7adns8	280	11	is	be	VBZ
cord-023168-cd7adns8	280	12	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	280	13	in	in	IN
cord-023168-cd7adns8	280	14	the	the	DT
cord-023168-cd7adns8	280	15	presence	presence	NN
cord-023168-cd7adns8	280	16	of	of	IN
cord-023168-cd7adns8	280	17	anaemia	anaemia	NN
cord-023168-cd7adns8	280	18	Very	very	RB
cord-023168-cd7adns8	280	19	high	high	JJ
cord-023168-cd7adns8	280	20	values	value	NNS
cord-023168-cd7adns8	280	21	(	(	-LRB-
cord-023168-cd7adns8	280	22	>	>	NFP
cord-023168-cd7adns8	280	23	100	100	CD
cord-023168-cd7adns8	280	24	µg	µg	NN
cord-023168-cd7adns8	280	25	/	/	SYM
cord-023168-cd7adns8	280	26	L	L	NNP
cord-023168-cd7adns8	280	27	)	)	-RRB-
cord-023168-cd7adns8	280	28	usually	usually	RB
cord-023168-cd7adns8	280	29	exclude	exclude	VBP
cord-023168-cd7adns8	280	30	iron	iron	NN
cord-023168-cd7adns8	280	31	deficiency	deficiency	NN
cord-023168-cd7adns8	280	32	'	'	''
cord-023168-cd7adns8	280	33	Being	be	VBG
cord-023168-cd7adns8	280	34	an	an	DT
cord-023168-cd7adns8	280	35	acute	acute	JJ
cord-023168-cd7adns8	280	36	-	-	HYPH
cord-023168-cd7adns8	280	37	phase	phase	NN
cord-023168-cd7adns8	280	38	protein	protein	NN
cord-023168-cd7adns8	280	39	,	,	,
cord-023168-cd7adns8	280	40	it	-PRON-	PRP
cord-023168-cd7adns8	280	41	increases	increase	VBZ
cord-023168-cd7adns8	280	42	in	in	IN
cord-023168-cd7adns8	280	43	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	280	44	conditions	condition	NNS
cord-023168-cd7adns8	280	45	,	,	,
cord-023168-cd7adns8	280	46	and	and	CC
cord-023168-cd7adns8	280	47	certain	certain	JJ
cord-023168-cd7adns8	280	48	malignancies	malignancy	NNS
cord-023168-cd7adns8	280	49	,	,	,
cord-023168-cd7adns8	280	50	making	make	VBG
cord-023168-cd7adns8	280	51	it	-PRON-	PRP
cord-023168-cd7adns8	280	52	unreliable	unreliable	JJ
cord-023168-cd7adns8	280	53	Also	also	RB
cord-023168-cd7adns8	280	54	increased	increase	VBD
cord-023168-cd7adns8	280	55	in	in	IN
cord-023168-cd7adns8	280	56	tissue	tissue	NN
cord-023168-cd7adns8	280	57	damage	damage	NN
cord-023168-cd7adns8	280	58	especially	especially	RB
cord-023168-cd7adns8	280	59	of	of	IN
cord-023168-cd7adns8	280	60	the	the	DT
cord-023168-cd7adns8	280	61	liver	liver	NN
cord-023168-cd7adns8	280	62	Levels	level	NNS
cord-023168-cd7adns8	280	63	are	be	VBP
cord-023168-cd7adns8	280	64	falsely	falsely	RB
cord-023168-cd7adns8	280	65	decreased	decrease	VBN
cord-023168-cd7adns8	280	66	in	in	IN
cord-023168-cd7adns8	280	67	vitamin	vitamin	NN
cord-023168-cd7adns8	280	68	C	C	NNP
cord-023168-cd7adns8	280	69	deficiency	deficiency	NN
cord-023168-cd7adns8	280	70	and	and	CC
cord-023168-cd7adns8	280	71	hypothyroidism	hypothyroidism	NN
cord-023168-cd7adns8	280	72	Erythrocyte	Erythrocyte	NNP
cord-023168-cd7adns8	280	73	zinc	zinc	NN
cord-023168-cd7adns8	280	74	protoporphyrin	protoporphyrin	NNP
cord-023168-cd7adns8	281	1	An	an	DT
cord-023168-cd7adns8	281	2	intermediate	intermediate	JJ
cord-023168-cd7adns8	281	3	in	in	IN
cord-023168-cd7adns8	281	4	haem	haem	NN
cord-023168-cd7adns8	281	5	biosynthesis	biosynthesis	NN
cord-023168-cd7adns8	281	6	and	and	CC
cord-023168-cd7adns8	281	7	elevated	elevated	JJ
cord-023168-cd7adns8	281	8	concentrations	concentration	NNS
cord-023168-cd7adns8	281	9	indicate	indicate	VBP
cord-023168-cd7adns8	281	10	interrupted	interrupt	VBN
cord-023168-cd7adns8	281	11	haem	haem	NN
cord-023168-cd7adns8	281	12	synthesis	synthesis	NN
cord-023168-cd7adns8	281	13	due	due	IN
cord-023168-cd7adns8	281	14	to	to	IN
cord-023168-cd7adns8	281	15	iron	iron	NN
cord-023168-cd7adns8	281	16	deficiency	deficiency	NN
cord-023168-cd7adns8	281	17	when	when	WRB
cord-023168-cd7adns8	281	18	zinc	zinc	NN
cord-023168-cd7adns8	281	19	is	be	VBZ
cord-023168-cd7adns8	281	20	incorporated	incorporate	VBN
cord-023168-cd7adns8	281	21	in	in	IN
cord-023168-cd7adns8	281	22	place	place	NN
cord-023168-cd7adns8	281	23	of	of	IN
cord-023168-cd7adns8	281	24	iron	iron	NN
cord-023168-cd7adns8	281	25	Can	Can	MD
cord-023168-cd7adns8	281	26	be	be	VB
cord-023168-cd7adns8	281	27	measured	measure	VBN
cord-023168-cd7adns8	281	28	on	on	IN
cord-023168-cd7adns8	281	29	a	a	DT
cord-023168-cd7adns8	281	30	drop	drop	NN
cord-023168-cd7adns8	281	31	of	of	IN
cord-023168-cd7adns8	281	32	blood	blood	NN
cord-023168-cd7adns8	281	33	with	with	IN
cord-023168-cd7adns8	281	34	a	a	DT
cord-023168-cd7adns8	281	35	portable	portable	JJ
cord-023168-cd7adns8	281	36	haematofluorometer	haematofluorometer	NN
cord-023168-cd7adns8	281	37	Small	small	JJ
cord-023168-cd7adns8	281	38	sample	sample	NN
cord-023168-cd7adns8	281	39	size	size	NN
cord-023168-cd7adns8	281	40	makes	make	VBZ
cord-023168-cd7adns8	281	41	it	-PRON-	PRP
cord-023168-cd7adns8	281	42	very	very	RB
cord-023168-cd7adns8	281	43	useful	useful	JJ
cord-023168-cd7adns8	281	44	as	as	IN
cord-023168-cd7adns8	281	45	a	a	DT
cord-023168-cd7adns8	281	46	screening	screening	NN
cord-023168-cd7adns8	281	47	test	test	NN
cord-023168-cd7adns8	281	48	in	in	IN
cord-023168-cd7adns8	281	49	field	field	NN
cord-023168-cd7adns8	281	50	surveys	survey	NNS
cord-023168-cd7adns8	281	51	,	,	,
cord-023168-cd7adns8	281	52	particularly	particularly	RB
cord-023168-cd7adns8	281	53	in	in	IN
cord-023168-cd7adns8	281	54	children	child	NNS
cord-023168-cd7adns8	281	55	,	,	,
cord-023168-cd7adns8	281	56	and	and	CC
cord-023168-cd7adns8	281	57	pregnant	pregnant	JJ
cord-023168-cd7adns8	281	58	women	woman	NNS
cord-023168-cd7adns8	281	59	where	where	WRB
cord-023168-cd7adns8	281	60	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	281	61	states	state	NNS
cord-023168-cd7adns8	281	62	may	may	MD
cord-023168-cd7adns8	281	63	not	not	RB
cord-023168-cd7adns8	281	64	co	co	VB
cord-023168-cd7adns8	281	65	-	-	VB
cord-023168-cd7adns8	281	66	exist	exist	VB
cord-023168-cd7adns8	281	67	Red	red	JJ
cord-023168-cd7adns8	281	68	cells	cell	NNS
cord-023168-cd7adns8	281	69	should	should	MD
cord-023168-cd7adns8	281	70	be	be	VB
cord-023168-cd7adns8	281	71	washed	wash	VBN
cord-023168-cd7adns8	281	72	before	before	IN
cord-023168-cd7adns8	281	73	measurement	measurement	NN
cord-023168-cd7adns8	281	74	(	(	-LRB-
cord-023168-cd7adns8	281	75	serum	serum	NN
cord-023168-cd7adns8	281	76	bilirubin	bilirubin	NN
cord-023168-cd7adns8	281	77	and	and	CC
cord-023168-cd7adns8	281	78	fluorescent	fluorescent	NN
cord-023168-cd7adns8	281	79	compounds	compound	NNS
cord-023168-cd7adns8	281	80	like	like	IN
cord-023168-cd7adns8	281	81	some	some	DT
cord-023168-cd7adns8	281	82	drugs	drug	NNS
cord-023168-cd7adns8	281	83	can	can	MD
cord-023168-cd7adns8	281	84	give	give	VB
cord-023168-cd7adns8	281	85	falsely	falsely	RB
cord-023168-cd7adns8	281	86	high	high	JJ
cord-023168-cd7adns8	281	87	values	value	NNS
cord-023168-cd7adns8	281	88	)	)	-RRB-
cord-023168-cd7adns8	281	89	although	although	IN
cord-023168-cd7adns8	281	90	not	not	RB
cord-023168-cd7adns8	281	91	often	often	RB
cord-023168-cd7adns8	281	92	done	do	VBN
cord-023168-cd7adns8	281	93	Lead	lead	NN
cord-023168-cd7adns8	281	94	poisoning	poisoning	NN
cord-023168-cd7adns8	281	95	can	can	MD
cord-023168-cd7adns8	281	96	give	give	VB
cord-023168-cd7adns8	281	97	falsely	falsely	RB
cord-023168-cd7adns8	281	98	high	high	JJ
cord-023168-cd7adns8	281	99	values	value	NNS
cord-023168-cd7adns8	281	100	Rarely	rarely	RB
cord-023168-cd7adns8	281	101	acute	acute	JJ
cord-023168-cd7adns8	281	102	myeloid	myeloid	JJ
cord-023168-cd7adns8	281	103	leukaemia	leukaemia	NN
cord-023168-cd7adns8	281	104	and	and	CC
cord-023168-cd7adns8	281	105	sideroblastic	sideroblastic	JJ
cord-023168-cd7adns8	281	106	anaemia	anaemia	NN
cord-023168-cd7adns8	281	107	give	give	VBP
cord-023168-cd7adns8	281	108	slightly	slightly	RB
cord-023168-cd7adns8	281	109	high	high	JJ
cord-023168-cd7adns8	281	110	values	value	NNS
cord-023168-cd7adns8	282	1	Useful	useful	JJ
cord-023168-cd7adns8	282	2	in	in	IN
cord-023168-cd7adns8	282	3	that	that	IN
cord-023168-cd7adns8	282	4	it	-PRON-	PRP
cord-023168-cd7adns8	282	5	is	be	VBZ
cord-023168-cd7adns8	282	6	not	not	RB
cord-023168-cd7adns8	282	7	increased	increase	VBN
cord-023168-cd7adns8	282	8	in	in	IN
cord-023168-cd7adns8	282	9	thalassaemias	thalassaemias	NNP
cord-023168-cd7adns8	282	10	WHO	who	WP
cord-023168-cd7adns8	282	11	recommends	recommend	VBZ
cord-023168-cd7adns8	282	12	normal	normal	JJ
cord-023168-cd7adns8	282	13	level	level	NN
cord-023168-cd7adns8	282	14	>	>	XX
cord-023168-cd7adns8	282	15	70	70	CD
cord-023168-cd7adns8	282	16	µmol	µmol	NNP
cord-023168-cd7adns8	282	17	/	/	SYM
cord-023168-cd7adns8	282	18	mol	mol	NN
cord-023168-cd7adns8	282	19	haem	haem	NN
cord-023168-cd7adns8	282	20	Iron	Iron	NNP
cord-023168-cd7adns8	282	21	studies	study	NNS
cord-023168-cd7adns8	283	1	Serum	serum	NN
cord-023168-cd7adns8	283	2	iron	iron	NN
cord-023168-cd7adns8	283	3	concentration	concentration	NN
cord-023168-cd7adns8	283	4	represents	represent	VBZ
cord-023168-cd7adns8	283	5	the	the	DT
cord-023168-cd7adns8	283	6	iron	iron	NN
cord-023168-cd7adns8	283	7	entering	enter	VBG
cord-023168-cd7adns8	283	8	and	and	CC
cord-023168-cd7adns8	283	9	leaving	leave	VBG
cord-023168-cd7adns8	283	10	the	the	DT
cord-023168-cd7adns8	283	11	circulation	circulation	NN
cord-023168-cd7adns8	283	12	.	.	.
cord-023168-cd7adns8	284	1	Its	-PRON-	PRP$
cord-023168-cd7adns8	284	2	range	range	NN
cord-023168-cd7adns8	284	3	varies	vary	VBZ
cord-023168-cd7adns8	284	4	widely	widely	RB
cord-023168-cd7adns8	284	5	with	with	IN
cord-023168-cd7adns8	284	6	age	age	NN
cord-023168-cd7adns8	284	7	,	,	,
cord-023168-cd7adns8	284	8	circadian	circadian	JJ
cord-023168-cd7adns8	284	9	rhythm	rhythm	NN
cord-023168-cd7adns8	284	10	,	,	,
cord-023168-cd7adns8	284	11	infections	infection	NNS
cord-023168-cd7adns8	284	12	and	and	CC
cord-023168-cd7adns8	284	13	iron	iron	NN
cord-023168-cd7adns8	284	14	ingestion	ingestion	NN
cord-023168-cd7adns8	284	15	Total	total	JJ
cord-023168-cd7adns8	284	16	iron	iron	NN
cord-023168-cd7adns8	284	17	binding	bind	VBG
cord-023168-cd7adns8	284	18	capacity	capacity	NN
cord-023168-cd7adns8	284	19	measures	measure	NNS
cord-023168-cd7adns8	284	20	iron	iron	NN
cord-023168-cd7adns8	284	21	bound	bind	VBN
cord-023168-cd7adns8	284	22	to	to	IN
cord-023168-cd7adns8	284	23	transferrin	transferrin	NN
cord-023168-cd7adns8	284	24	.	.	.
cord-023168-cd7adns8	285	1	Raised	raise	VBN
cord-023168-cd7adns8	285	2	levels	level	NNS
cord-023168-cd7adns8	285	3	are	be	VBP
cord-023168-cd7adns8	285	4	suggestive	suggestive	JJ
cord-023168-cd7adns8	285	5	of	of	IN
cord-023168-cd7adns8	285	6	iron	iron	NN
cord-023168-cd7adns8	285	7	deficiency	deficiency	NN
cord-023168-cd7adns8	285	8	Transferrin	Transferrin	NNP
cord-023168-cd7adns8	285	9	saturation	saturation	NN
cord-023168-cd7adns8	285	10	is	be	VBZ
cord-023168-cd7adns8	285	11	the	the	DT
cord-023168-cd7adns8	285	12	ratio	ratio	NN
cord-023168-cd7adns8	285	13	of	of	IN
cord-023168-cd7adns8	285	14	serum	serum	NN
cord-023168-cd7adns8	285	15	iron	iron	NN
cord-023168-cd7adns8	285	16	and	and	CC
cord-023168-cd7adns8	285	17	the	the	DT
cord-023168-cd7adns8	285	18	TIBC	TIBC	NNP
cord-023168-cd7adns8	285	19	expressed	express	VBD
cord-023168-cd7adns8	285	20	as	as	IN
cord-023168-cd7adns8	285	21	a	a	DT
cord-023168-cd7adns8	285	22	percentage	percentage	NN
cord-023168-cd7adns8	286	1	-It	-It	:
cord-023168-cd7adns8	286	2	is	be	VBZ
cord-023168-cd7adns8	286	3	probably	probably	RB
cord-023168-cd7adns8	286	4	more	more	RBR
cord-023168-cd7adns8	286	5	useful	useful	JJ
cord-023168-cd7adns8	286	6	in	in	IN
cord-023168-cd7adns8	286	7	detecting	detect	VBG
cord-023168-cd7adns8	286	8	iron	iron	NN
cord-023168-cd7adns8	286	9	overload	overload	NN
cord-023168-cd7adns8	286	10	rather	rather	RB
cord-023168-cd7adns8	286	11	than	than	IN
cord-023168-cd7adns8	286	12	low	low	JJ
cord-023168-cd7adns8	286	13	levels	level	NNS
cord-023168-cd7adns8	286	14	.	.	.
cord-023168-cd7adns8	287	1	Sensitive	sensitive	JJ
cord-023168-cd7adns8	287	2	indicator	indicator	NN
cord-023168-cd7adns8	287	3	that	that	WDT
cord-023168-cd7adns8	287	4	falls	fall	VBZ
cord-023168-cd7adns8	287	5	within	within	IN
cord-023168-cd7adns8	287	6	days	day	NNS
cord-023168-cd7adns8	287	7	of	of	IN
cord-023168-cd7adns8	287	8	onset	onset	NN
cord-023168-cd7adns8	287	9	of	of	IN
cord-023168-cd7adns8	287	10	iron	iron	NN
cord-023168-cd7adns8	287	11	-	-	HYPH
cord-023168-cd7adns8	287	12	deficiency	deficiency	NN
cord-023168-cd7adns8	287	13	Reduced	reduce	VBN
cord-023168-cd7adns8	287	14	levels	level	NNS
cord-023168-cd7adns8	287	15	shown	show	VBN
cord-023168-cd7adns8	287	16	to	to	TO
cord-023168-cd7adns8	287	17	be	be	VB
cord-023168-cd7adns8	287	18	predictor	predictor	NN
cord-023168-cd7adns8	287	19	of	of	IN
cord-023168-cd7adns8	287	20	iron	iron	NN
cord-023168-cd7adns8	287	21	deficiency	deficiency	NN
cord-023168-cd7adns8	287	22	especially	especially	RB
cord-023168-cd7adns8	287	23	in	in	IN
cord-023168-cd7adns8	287	24	the	the	DT
cord-023168-cd7adns8	287	25	setting	setting	NN
cord-023168-cd7adns8	287	26	of	of	IN
cord-023168-cd7adns8	287	27	renal	renal	JJ
cord-023168-cd7adns8	287	28	insufficiency	insufficiency	NN
cord-023168-cd7adns8	287	29	False	false	JJ
cord-023168-cd7adns8	287	30	normal	normal	JJ
cord-023168-cd7adns8	287	31	values	value	NNS
cord-023168-cd7adns8	287	32	can	can	MD
cord-023168-cd7adns8	287	33	occur	occur	VB
cord-023168-cd7adns8	287	34	when	when	WRB
cord-023168-cd7adns8	287	35	MCV	MCV	NNP
cord-023168-cd7adns8	287	36	is	be	VBZ
cord-023168-cd7adns8	287	37	increased	increase	VBN
cord-023168-cd7adns8	287	38	or	or	CC
cord-023168-cd7adns8	287	39	in	in	IN
cord-023168-cd7adns8	287	40	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	287	41	Serum	Serum	NNP
cord-023168-cd7adns8	287	42	transferrin	transferrin	NN
cord-023168-cd7adns8	287	43	receptor	receptor	NN
cord-023168-cd7adns8	288	1	It	-PRON-	PRP
cord-023168-cd7adns8	288	2	is	be	VBZ
cord-023168-cd7adns8	288	3	not	not	RB
cord-023168-cd7adns8	288	4	increased	increase	VBN
cord-023168-cd7adns8	288	5	in	in	IN
cord-023168-cd7adns8	288	6	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	288	7	conditions	condition	NNS
cord-023168-cd7adns8	288	8	May	May	MD
cord-023168-cd7adns8	288	9	be	be	VB
cord-023168-cd7adns8	288	10	upregulated	upregulate	VBN
cord-023168-cd7adns8	288	11	by	by	IN
cord-023168-cd7adns8	288	12	increased	increase	VBN
cord-023168-cd7adns8	288	13	erythropoiesis	erythropoiesis	NNP
cord-023168-cd7adns8	288	14	(	(	-LRB-
cord-023168-cd7adns8	288	15	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	288	16	diseases	disease	NNS
cord-023168-cd7adns8	288	17	)	)	-RRB-
cord-023168-cd7adns8	288	18	giving	give	VBG
cord-023168-cd7adns8	288	19	falsely	falsely	RB
cord-023168-cd7adns8	288	20	high	high	JJ
cord-023168-cd7adns8	288	21	values	value	NNS
cord-023168-cd7adns8	288	22	-serum	-serum	.
cord-023168-cd7adns8	289	1	transferrin	transferrin	NN
cord-023168-cd7adns8	289	2	receptor	receptor	NN
cord-023168-cd7adns8	289	3	to	to	IN
cord-023168-cd7adns8	289	4	ferritin	ferritin	NN
cord-023168-cd7adns8	289	5	ratio	ratio	NN
cord-023168-cd7adns8	289	6	has	have	VBZ
cord-023168-cd7adns8	289	7	been	be	VBN
cord-023168-cd7adns8	289	8	suggested	suggest	VBN
cord-023168-cd7adns8	289	9	in	in	IN
cord-023168-cd7adns8	289	10	these	these	DT
cord-023168-cd7adns8	289	11	cases	case	NNS
cord-023168-cd7adns8	289	12	Bone	Bone	NNP
cord-023168-cd7adns8	289	13	marrow	marrow	NN
cord-023168-cd7adns8	289	14	examination	examination	NN
cord-023168-cd7adns8	289	15	with	with	IN
cord-023168-cd7adns8	289	16	special	special	JJ
cord-023168-cd7adns8	289	17	iron	iron	NN
cord-023168-cd7adns8	289	18	staining	staining	NN
cord-023168-cd7adns8	289	19	(	(	-LRB-
cord-023168-cd7adns8	289	20	Perl	Perl	NNP
cord-023168-cd7adns8	289	21	's	's	POS
cord-023168-cd7adns8	289	22	)	)	-RRB-
cord-023168-cd7adns8	289	23	Absence	absence	NN
cord-023168-cd7adns8	289	24	of	of	IN
cord-023168-cd7adns8	289	25	stainable	stainable	JJ
cord-023168-cd7adns8	289	26	iron	iron	NN
cord-023168-cd7adns8	289	27	in	in	IN
cord-023168-cd7adns8	289	28	a	a	DT
cord-023168-cd7adns8	289	29	sample	sample	NN
cord-023168-cd7adns8	289	30	that	that	WDT
cord-023168-cd7adns8	289	31	contains	contain	VBZ
cord-023168-cd7adns8	289	32	particles	particle	NNS
cord-023168-cd7adns8	289	33	can	can	MD
cord-023168-cd7adns8	289	34	establish	establish	VB
cord-023168-cd7adns8	289	35	the	the	DT
cord-023168-cd7adns8	289	36	diagnosis	diagnosis	NN
cord-023168-cd7adns8	289	37	without	without	IN
cord-023168-cd7adns8	289	38	other	other	JJ
cord-023168-cd7adns8	289	39	laboratory	laboratory	NN
cord-023168-cd7adns8	289	40	tests	test	NNS
cord-023168-cd7adns8	290	1	A	a	DT
cord-023168-cd7adns8	290	2	simultaneous	simultaneous	JJ
cord-023168-cd7adns8	290	3	control	control	NN
cord-023168-cd7adns8	290	4	specimen	specimen	NN
cord-023168-cd7adns8	290	5	containing	contain	VBG
cord-023168-cd7adns8	290	6	stainable	stainable	JJ
cord-023168-cd7adns8	290	7	iron	iron	NN
cord-023168-cd7adns8	290	8	should	should	MD
cord-023168-cd7adns8	290	9	also	also	RB
cord-023168-cd7adns8	290	10	be	be	VB
cord-023168-cd7adns8	290	11	assessed	assess	VBN
cord-023168-cd7adns8	290	12	Useful	useful	JJ
cord-023168-cd7adns8	290	13	in	in	IN
cord-023168-cd7adns8	290	14	differentiating	differentiate	VBG
cord-023168-cd7adns8	290	15	from	from	IN
cord-023168-cd7adns8	290	16	anaemia	anaemia	NN
cord-023168-cd7adns8	290	17	of	of	IN
cord-023168-cd7adns8	290	18	chronic	chronic	JJ
cord-023168-cd7adns8	290	19	disorders	disorder	NNS
cord-023168-cd7adns8	290	20	or	or	CC
cord-023168-cd7adns8	290	21	α	α	NN
cord-023168-cd7adns8	290	22	-	-	HYPH
cord-023168-cd7adns8	290	23	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	290	24	or	or	CC
cord-023168-cd7adns8	290	25	milder	mild	JJR
cord-023168-cd7adns8	290	26	forms	form	NNS
cord-023168-cd7adns8	290	27	of	of	IN
cord-023168-cd7adns8	290	28	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	290	29	Can	Can	MD
cord-023168-cd7adns8	290	30	help	help	VB
cord-023168-cd7adns8	290	31	in	in	IN
cord-023168-cd7adns8	290	32	identifying	identify	VBG
cord-023168-cd7adns8	290	33	the	the	DT
cord-023168-cd7adns8	290	34	sideroblastic	sideroblastic	JJ
cord-023168-cd7adns8	290	35	anaemias	anaemias	NNP
cord-023168-cd7adns8	290	36	(	(	-LRB-
cord-023168-cd7adns8	290	37	ring	ring	VB
cord-023168-cd7adns8	290	38	sideroblasts	sideroblast	NNS
cord-023168-cd7adns8	290	39	with	with	IN
cord-023168-cd7adns8	290	40	Perls	Perls	NNP
cord-023168-cd7adns8	290	41	stain	stain	NN
cord-023168-cd7adns8	290	42	)	)	-RRB-
cord-023168-cd7adns8	290	43	,	,	,
cord-023168-cd7adns8	290	44	and	and	CC
cord-023168-cd7adns8	290	45	some	some	DT
cord-023168-cd7adns8	290	46	forms	form	NNS
cord-023168-cd7adns8	290	47	of	of	IN
cord-023168-cd7adns8	290	48	congenital	congenital	JJ
cord-023168-cd7adns8	290	49	dyserythropoietic	dyserythropoietic	JJ
cord-023168-cd7adns8	290	50	anaemia	anaemia	NN
cord-023168-cd7adns8	290	51	which	which	WDT
cord-023168-cd7adns8	290	52	can	can	MD
cord-023168-cd7adns8	290	53	also	also	RB
cord-023168-cd7adns8	290	54	cause	cause	VB
cord-023168-cd7adns8	290	55	microcytosis	microcytosis	NNP
cord-023168-cd7adns8	290	56	.	.	.
cord-023168-cd7adns8	291	1	An	an	DT
cord-023168-cd7adns8	291	2	improvement	improvement	NN
cord-023168-cd7adns8	291	3	in	in	IN
cord-023168-cd7adns8	291	4	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	291	5	and	and	CC
cord-023168-cd7adns8	291	6	clinical	clinical	JJ
cord-023168-cd7adns8	291	7	symptoms	symptom	NNS
cord-023168-cd7adns8	291	8	with	with	IN
cord-023168-cd7adns8	291	9	iron	iron	NN
cord-023168-cd7adns8	291	10	replacement	replacement	NN
cord-023168-cd7adns8	291	11	is	be	VBZ
cord-023168-cd7adns8	291	12	probably	probably	RB
cord-023168-cd7adns8	291	13	the	the	DT
cord-023168-cd7adns8	291	14	simplest	simple	JJS
cord-023168-cd7adns8	291	15	way	way	NN
cord-023168-cd7adns8	291	16	to	to	TO
cord-023168-cd7adns8	291	17	diagnose	diagnose	VB
cord-023168-cd7adns8	291	18	iron	iron	NN
cord-023168-cd7adns8	291	19	deficiency	deficiency	NN
cord-023168-cd7adns8	291	20	.	.	.
cord-023168-cd7adns8	292	1	Peripheral	peripheral	JJ
cord-023168-cd7adns8	292	2	smear	smear	NN
cord-023168-cd7adns8	292	3	may	may	MD
cord-023168-cd7adns8	292	4	help	help	VB
cord-023168-cd7adns8	292	5	by	by	IN
cord-023168-cd7adns8	292	6	demonstrating	demonstrate	VBG
cord-023168-cd7adns8	292	7	pencil	pencil	NN
cord-023168-cd7adns8	292	8	cells	cell	NNS
cord-023168-cd7adns8	292	9	,	,	,
cord-023168-cd7adns8	292	10	anisopoikilocytosis	anisopoikilocytosis	NN
cord-023168-cd7adns8	292	11	and	and	CC
cord-023168-cd7adns8	292	12	high	high	JJ
cord-023168-cd7adns8	292	13	platelet	platelet	NN
cord-023168-cd7adns8	292	14	number	number	NN
cord-023168-cd7adns8	292	15	in	in	IN
cord-023168-cd7adns8	292	16	cases	case	NNS
cord-023168-cd7adns8	292	17	of	of	IN
cord-023168-cd7adns8	292	18	blood	blood	NN
cord-023168-cd7adns8	292	19	loss	loss	NN
cord-023168-cd7adns8	292	20	.	.	.
cord-023168-cd7adns8	293	1	The	the	DT
cord-023168-cd7adns8	293	2	treatment	treatment	NN
cord-023168-cd7adns8	293	3	of	of	IN
cord-023168-cd7adns8	293	4	vitamin	vitamin	NN
cord-023168-cd7adns8	293	5	B	b	NN
cord-023168-cd7adns8	293	6	12	12	CD
cord-023168-cd7adns8	293	7	deficiency	deficiency	NN
cord-023168-cd7adns8	293	8	can	can	MD
cord-023168-cd7adns8	293	9	be	be	VB
cord-023168-cd7adns8	293	10	by	by	IN
cord-023168-cd7adns8	293	11	the	the	DT
cord-023168-cd7adns8	293	12	oral	oral	JJ
cord-023168-cd7adns8	293	13	or	or	CC
cord-023168-cd7adns8	293	14	parenteral	parenteral	JJ
cord-023168-cd7adns8	293	15	route	route	NN
cord-023168-cd7adns8	293	16	.	.	.
cord-023168-cd7adns8	294	1	37	37	CD
cord-023168-cd7adns8	294	2	Increasing	increase	VBG
cord-023168-cd7adns8	294	3	evidence	evidence	NN
cord-023168-cd7adns8	294	4	suggests	suggest	VBZ
cord-023168-cd7adns8	294	5	that	that	IN
cord-023168-cd7adns8	294	6	oral	oral	JJ
cord-023168-cd7adns8	294	7	supplementation	supplementation	NN
cord-023168-cd7adns8	294	8	may	may	MD
cord-023168-cd7adns8	294	9	be	be	VB
cord-023168-cd7adns8	294	10	adequate	adequate	JJ
cord-023168-cd7adns8	294	11	even	even	RB
cord-023168-cd7adns8	294	12	in	in	IN
cord-023168-cd7adns8	294	13	the	the	DT
cord-023168-cd7adns8	294	14	presence	presence	NN
cord-023168-cd7adns8	294	15	of	of	IN
cord-023168-cd7adns8	294	16	malabsorption	malabsorption	NN
cord-023168-cd7adns8	294	17	or	or	CC
cord-023168-cd7adns8	294	18	pernicious	pernicious	JJ
cord-023168-cd7adns8	294	19	anaemia	anaemia	NN
cord-023168-cd7adns8	294	20	.	.	.
cord-023168-cd7adns8	295	1	38	38	CD
cord-023168-cd7adns8	295	2	,	,	,
cord-023168-cd7adns8	295	3	39	39	CD
cord-023168-cd7adns8	296	1	The	the	DT
cord-023168-cd7adns8	296	2	recommended	recommend	VBN
cord-023168-cd7adns8	296	3	initial	initial	JJ
cord-023168-cd7adns8	296	4	oral	oral	JJ
cord-023168-cd7adns8	296	5	replacement	replacement	NN
cord-023168-cd7adns8	296	6	dosage	dosage	NN
cord-023168-cd7adns8	296	7	is	be	VBZ
cord-023168-cd7adns8	296	8	1	1	CD
cord-023168-cd7adns8	296	9	-	-	SYM
cord-023168-cd7adns8	296	10	2	2	CD
cord-023168-cd7adns8	296	11	mg	mg	NN
cord-023168-cd7adns8	296	12	but	but	CC
cord-023168-cd7adns8	296	13	higher	high	JJR
cord-023168-cd7adns8	296	14	doses	dose	NNS
cord-023168-cd7adns8	296	15	may	may	MD
cord-023168-cd7adns8	296	16	be	be	VB
cord-023168-cd7adns8	296	17	needed	need	VBN
cord-023168-cd7adns8	296	18	for	for	IN
cord-023168-cd7adns8	296	19	malabsorption	malabsorption	NN
cord-023168-cd7adns8	296	20	or	or	CC
cord-023168-cd7adns8	296	21	pernicious	pernicious	JJ
cord-023168-cd7adns8	296	22	anaemia	anaemia	NN
cord-023168-cd7adns8	296	23	.	.	.
cord-023168-cd7adns8	297	1	40	40	CD
cord-023168-cd7adns8	298	1	For	for	IN
cord-023168-cd7adns8	298	2	patients	patient	NNS
cord-023168-cd7adns8	298	3	with	with	IN
cord-023168-cd7adns8	298	4	severe	severe	JJ
cord-023168-cd7adns8	298	5	anaemia	anaemia	NN
cord-023168-cd7adns8	298	6	and/or	and/or	CC
cord-023168-cd7adns8	298	7	neurological	neurological	JJ
cord-023168-cd7adns8	298	8	disease	disease	NN
cord-023168-cd7adns8	298	9	,	,	,
cord-023168-cd7adns8	298	10	daily	daily	JJ
cord-023168-cd7adns8	298	11	or	or	CC
cord-023168-cd7adns8	298	12	alternate	alternate	JJ
cord-023168-cd7adns8	298	13	day	day	NN
cord-023168-cd7adns8	298	14	intramuscular	intramuscular	JJ
cord-023168-cd7adns8	298	15	injections	injection	NNS
cord-023168-cd7adns8	298	16	should	should	MD
cord-023168-cd7adns8	298	17	be	be	VB
cord-023168-cd7adns8	298	18	initiated	initiate	VBN
cord-023168-cd7adns8	298	19	for	for	IN
cord-023168-cd7adns8	298	20	the	the	DT
cord-023168-cd7adns8	298	21	first	first	JJ
cord-023168-cd7adns8	298	22	2	2	CD
cord-023168-cd7adns8	298	23	-	-	SYM
cord-023168-cd7adns8	298	24	4	4	CD
cord-023168-cd7adns8	298	25	weeks	week	NNS
cord-023168-cd7adns8	298	26	before	before	IN
cord-023168-cd7adns8	298	27	reverting	revert	VBG
cord-023168-cd7adns8	298	28	to	to	IN
cord-023168-cd7adns8	298	29	the	the	DT
cord-023168-cd7adns8	298	30	maintenance	maintenance	NN
cord-023168-cd7adns8	298	31	threemonthly	threemonthly	RB
cord-023168-cd7adns8	298	32	dose	dose	NN
cord-023168-cd7adns8	298	33	.	.	.
cord-023168-cd7adns8	299	1	Reticulocytosis	Reticulocytosis	NNP
cord-023168-cd7adns8	299	2	is	be	VBZ
cord-023168-cd7adns8	299	3	an	an	DT
cord-023168-cd7adns8	299	4	early	early	JJ
cord-023168-cd7adns8	299	5	marker	marker	NN
cord-023168-cd7adns8	299	6	of	of	IN
cord-023168-cd7adns8	299	7	response	response	NN
cord-023168-cd7adns8	299	8	to	to	IN
cord-023168-cd7adns8	299	9	treatment	treatment	NN
cord-023168-cd7adns8	299	10	and	and	CC
cord-023168-cd7adns8	299	11	is	be	VBZ
cord-023168-cd7adns8	299	12	noticeable	noticeable	JJ
cord-023168-cd7adns8	299	13	within	within	IN
cord-023168-cd7adns8	299	14	1	1	CD
cord-023168-cd7adns8	299	15	-	-	SYM
cord-023168-cd7adns8	299	16	2	2	CD
cord-023168-cd7adns8	299	17	weeks	week	NNS
cord-023168-cd7adns8	299	18	.	.	.
cord-023168-cd7adns8	300	1	Folic	folic	JJ
cord-023168-cd7adns8	300	2	acid	acid	JJ
cord-023168-cd7adns8	300	3	deficiency	deficiency	NN
cord-023168-cd7adns8	300	4	causes	cause	VBZ
cord-023168-cd7adns8	300	5	similar	similar	JJ
cord-023168-cd7adns8	300	6	haematological	haematological	JJ
cord-023168-cd7adns8	300	7	manifestations	manifestation	NNS
cord-023168-cd7adns8	300	8	to	to	IN
cord-023168-cd7adns8	300	9	vitamin	vitamin	NN
cord-023168-cd7adns8	300	10	B	b	NN
cord-023168-cd7adns8	300	11	12	12	CD
cord-023168-cd7adns8	300	12	deficiency	deficiency	NN
cord-023168-cd7adns8	300	13	though	though	IN
cord-023168-cd7adns8	300	14	neuropsychiatric	neuropsychiatric	JJ
cord-023168-cd7adns8	300	15	manifestations	manifestation	NNS
cord-023168-cd7adns8	300	16	are	be	VBP
cord-023168-cd7adns8	300	17	less	less	RBR
cord-023168-cd7adns8	300	18	common	common	JJ
cord-023168-cd7adns8	300	19	.	.	.
cord-023168-cd7adns8	301	1	The	the	DT
cord-023168-cd7adns8	301	2	ability	ability	NN
cord-023168-cd7adns8	301	3	of	of	IN
cord-023168-cd7adns8	301	4	nerve	nerve	JJ
cord-023168-cd7adns8	301	5	tissue	tissue	NN
cord-023168-cd7adns8	301	6	to	to	TO
cord-023168-cd7adns8	301	7	concentrate	concentrate	VB
cord-023168-cd7adns8	301	8	folate	folate	NN
cord-023168-cd7adns8	301	9	to	to	IN
cord-023168-cd7adns8	301	10	levels	level	NNS
cord-023168-cd7adns8	301	11	five	five	CD
cord-023168-cd7adns8	301	12	times	time	NNS
cord-023168-cd7adns8	301	13	greater	great	JJR
cord-023168-cd7adns8	301	14	than	than	IN
cord-023168-cd7adns8	301	15	those	those	DT
cord-023168-cd7adns8	301	16	in	in	IN
cord-023168-cd7adns8	301	17	the	the	DT
cord-023168-cd7adns8	301	18	plasma	plasma	NN
cord-023168-cd7adns8	301	19	has	have	VBZ
cord-023168-cd7adns8	301	20	been	be	VBN
cord-023168-cd7adns8	301	21	suggested	suggest	VBN
cord-023168-cd7adns8	301	22	as	as	IN
cord-023168-cd7adns8	301	23	a	a	DT
cord-023168-cd7adns8	301	24	reason	reason	NN
cord-023168-cd7adns8	301	25	for	for	IN
cord-023168-cd7adns8	301	26	the	the	DT
cord-023168-cd7adns8	301	27	absence	absence	NN
cord-023168-cd7adns8	301	28	of	of	IN
cord-023168-cd7adns8	301	29	neuropathy	neuropathy	NN
cord-023168-cd7adns8	301	30	in	in	IN
cord-023168-cd7adns8	301	31	folate	folate	JJ
cord-023168-cd7adns8	301	32	deficiency	deficiency	NN
cord-023168-cd7adns8	301	33	.	.	.
cord-023168-cd7adns8	302	1	Folic	folic	JJ
cord-023168-cd7adns8	302	2	acid	acid	JJ
cord-023168-cd7adns8	302	3	deficiency	deficiency	NN
cord-023168-cd7adns8	302	4	is	be	VBZ
cord-023168-cd7adns8	302	5	associated	associate	VBN
cord-023168-cd7adns8	302	6	with	with	IN
cord-023168-cd7adns8	302	7	fetal	fetal	JJ
cord-023168-cd7adns8	302	8	neural	neural	JJ
cord-023168-cd7adns8	302	9	tube	tube	NN
cord-023168-cd7adns8	302	10	defects	defect	NNS
cord-023168-cd7adns8	302	11	,	,	,
cord-023168-cd7adns8	302	12	and	and	CC
cord-023168-cd7adns8	302	13	possibly	possibly	RB
cord-023168-cd7adns8	302	14	with	with	IN
cord-023168-cd7adns8	302	15	an	an	DT
cord-023168-cd7adns8	302	16	increase	increase	NN
cord-023168-cd7adns8	302	17	in	in	IN
cord-023168-cd7adns8	302	18	atherosclerosis	atherosclerosis	NN
cord-023168-cd7adns8	302	19	and	and	CC
cord-023168-cd7adns8	302	20	arteriovenous	arteriovenous	JJ
cord-023168-cd7adns8	302	21	thrombosis	thrombosis	NN
cord-023168-cd7adns8	302	22	,	,	,
cord-023168-cd7adns8	302	23	dementia	dementia	NN
cord-023168-cd7adns8	302	24	and	and	CC
cord-023168-cd7adns8	302	25	colonic	colonic	JJ
cord-023168-cd7adns8	302	26	cancer	cancer	NN
cord-023168-cd7adns8	302	27	.	.	.
cord-023168-cd7adns8	303	1	Dietary	dietary	JJ
cord-023168-cd7adns8	303	2	folic	folic	JJ
cord-023168-cd7adns8	303	3	acid	acid	NN
cord-023168-cd7adns8	303	4	is	be	VBZ
cord-023168-cd7adns8	303	5	present	present	JJ
cord-023168-cd7adns8	303	6	in	in	IN
cord-023168-cd7adns8	303	7	the	the	DT
cord-023168-cd7adns8	303	8	form	form	NN
cord-023168-cd7adns8	303	9	of	of	IN
cord-023168-cd7adns8	303	10	polyglutamates	polyglutamate	NNS
cord-023168-cd7adns8	303	11	,	,	,
cord-023168-cd7adns8	303	12	which	which	WDT
cord-023168-cd7adns8	303	13	are	be	VBP
cord-023168-cd7adns8	303	14	converted	convert	VBN
cord-023168-cd7adns8	303	15	to	to	IN
cord-023168-cd7adns8	303	16	folate	folate	VB
cord-023168-cd7adns8	303	17	monoglutamates	monoglutamate	NNS
cord-023168-cd7adns8	303	18	by	by	IN
cord-023168-cd7adns8	303	19	the	the	DT
cord-023168-cd7adns8	303	20	enzyme	enzyme	NN
cord-023168-cd7adns8	303	21	folate	folate	NN
cord-023168-cd7adns8	303	22	conjugase	conjugase	NN
cord-023168-cd7adns8	303	23	in	in	IN
cord-023168-cd7adns8	303	24	the	the	DT
cord-023168-cd7adns8	303	25	intestinal	intestinal	JJ
cord-023168-cd7adns8	303	26	brush	brush	NN
cord-023168-cd7adns8	303	27	border	border	NN
cord-023168-cd7adns8	303	28	,	,	,
cord-023168-cd7adns8	303	29	prior	prior	RB
cord-023168-cd7adns8	303	30	to	to	IN
cord-023168-cd7adns8	303	31	absorption	absorption	NN
cord-023168-cd7adns8	303	32	.	.	.
cord-023168-cd7adns8	304	1	The	the	DT
cord-023168-cd7adns8	304	2	monoglutamates	monoglutamate	NNS
cord-023168-cd7adns8	304	3	function	function	VBP
cord-023168-cd7adns8	304	4	as	as	IN
cord-023168-cd7adns8	304	5	a	a	DT
cord-023168-cd7adns8	304	6	carbon	carbon	NN
cord-023168-cd7adns8	304	7	transporter	transporter	NN
cord-023168-cd7adns8	304	8	and	and	CC
cord-023168-cd7adns8	304	9	are	be	VBP
cord-023168-cd7adns8	304	10	essential	essential	JJ
cord-023168-cd7adns8	304	11	for	for	IN
cord-023168-cd7adns8	304	12	DNA	dna	NN
cord-023168-cd7adns8	304	13	biosynthesis	biosynthesis	NN
cord-023168-cd7adns8	304	14	.	.	.
cord-023168-cd7adns8	305	1	Folate	folate	NN
cord-023168-cd7adns8	305	2	is	be	VBZ
cord-023168-cd7adns8	305	3	found	find	VBN
cord-023168-cd7adns8	305	4	in	in	IN
cord-023168-cd7adns8	305	5	green	green	JJ
cord-023168-cd7adns8	305	6	vegetables	vegetable	NNS
cord-023168-cd7adns8	305	7	and	and	CC
cord-023168-cd7adns8	305	8	fruits	fruit	NNS
cord-023168-cd7adns8	305	9	and	and	CC
cord-023168-cd7adns8	305	10	deficiency	deficiency	NN
cord-023168-cd7adns8	305	11	can	can	MD
cord-023168-cd7adns8	305	12	result	result	VB
cord-023168-cd7adns8	305	13	from	from	IN
cord-023168-cd7adns8	305	14	decreased	decrease	VBN
cord-023168-cd7adns8	305	15	intake	intake	NN
cord-023168-cd7adns8	305	16	,	,	,
cord-023168-cd7adns8	305	17	impaired	impaired	JJ
cord-023168-cd7adns8	305	18	absorption	absorption	NN
cord-023168-cd7adns8	305	19	and	and	CC
cord-023168-cd7adns8	305	20	increased	increase	VBN
cord-023168-cd7adns8	305	21	utilization	utilization	NN
cord-023168-cd7adns8	305	22	,	,	,
cord-023168-cd7adns8	305	23	although	although	IN
cord-023168-cd7adns8	305	24	the	the	DT
cord-023168-cd7adns8	305	25	commonest	common	JJS
cord-023168-cd7adns8	305	26	cause	cause	NN
cord-023168-cd7adns8	305	27	is	be	VBZ
cord-023168-cd7adns8	305	28	dietary	dietary	JJ
cord-023168-cd7adns8	305	29	insufficiency	insufficiency	NN
cord-023168-cd7adns8	305	30	.	.	.
cord-023168-cd7adns8	306	1	41	41	CD
cord-023168-cd7adns8	307	1	In	in	IN
cord-023168-cd7adns8	307	2	some	some	DT
cord-023168-cd7adns8	307	3	wealthy	wealthy	JJ
cord-023168-cd7adns8	307	4	countries	country	NNS
cord-023168-cd7adns8	307	5	,	,	,
cord-023168-cd7adns8	307	6	cereals	cereal	NNS
cord-023168-cd7adns8	307	7	have	have	VBP
cord-023168-cd7adns8	307	8	been	be	VBN
cord-023168-cd7adns8	307	9	fortified	fortify	VBN
cord-023168-cd7adns8	307	10	with	with	IN
cord-023168-cd7adns8	307	11	folic	folic	JJ
cord-023168-cd7adns8	307	12	acid	acid	NN
cord-023168-cd7adns8	307	13	to	to	TO
cord-023168-cd7adns8	307	14	successfully	successfully	RB
cord-023168-cd7adns8	307	15	prevent	prevent	VB
cord-023168-cd7adns8	307	16	vitamin	vitamin	NN
cord-023168-cd7adns8	307	17	deficiency	deficiency	NN
cord-023168-cd7adns8	307	18	.	.	.
cord-023168-cd7adns8	308	1	However	however	WRB
cord-023168-cd7adns8	308	2	folate	folate	JJ
cord-023168-cd7adns8	308	3	deficiency	deficiency	NN
cord-023168-cd7adns8	308	4	continues	continue	VBZ
cord-023168-cd7adns8	308	5	to	to	TO
cord-023168-cd7adns8	308	6	be	be	VB
cord-023168-cd7adns8	308	7	a	a	DT
cord-023168-cd7adns8	308	8	problem	problem	NN
cord-023168-cd7adns8	308	9	in	in	IN
cord-023168-cd7adns8	308	10	less	less	RBR
cord-023168-cd7adns8	308	11	wealthy	wealthy	JJ
cord-023168-cd7adns8	308	12	countries	country	NNS
cord-023168-cd7adns8	308	13	and	and	CC
cord-023168-cd7adns8	308	14	particularly	particularly	RB
cord-023168-cd7adns8	308	15	among	among	IN
cord-023168-cd7adns8	308	16	children	child	NNS
cord-023168-cd7adns8	308	17	and	and	CC
cord-023168-cd7adns8	308	18	pregnant	pregnant	JJ
cord-023168-cd7adns8	308	19	women	woman	NNS
cord-023168-cd7adns8	308	20	.	.	.
cord-023168-cd7adns8	309	1	42	42	CD
cord-023168-cd7adns8	309	2	,	,	,
cord-023168-cd7adns8	309	3	43	43	CD
cord-023168-cd7adns8	309	4	Exclusive	exclusive	JJ
cord-023168-cd7adns8	309	5	feeding	feeding	NN
cord-023168-cd7adns8	309	6	of	of	IN
cord-023168-cd7adns8	309	7	goat	goat	NN
cord-023168-cd7adns8	309	8	's	's	POS
cord-023168-cd7adns8	309	9	milk	milk	NN
cord-023168-cd7adns8	309	10	to	to	IN
cord-023168-cd7adns8	309	11	infants	infant	NNS
cord-023168-cd7adns8	309	12	can	can	MD
cord-023168-cd7adns8	309	13	lead	lead	VB
cord-023168-cd7adns8	309	14	to	to	IN
cord-023168-cd7adns8	309	15	folate	folate	JJ
cord-023168-cd7adns8	309	16	deficiency	deficiency	NN
cord-023168-cd7adns8	309	17	.	.	.
cord-023168-cd7adns8	310	1	Other	other	JJ
cord-023168-cd7adns8	310	2	causes	cause	NNS
cord-023168-cd7adns8	310	3	include	include	VBP
cord-023168-cd7adns8	310	4	alcoholism	alcoholism	NN
cord-023168-cd7adns8	310	5	,	,	,
cord-023168-cd7adns8	310	6	excessive	excessive	JJ
cord-023168-cd7adns8	310	7	cooking	cooking	NN
cord-023168-cd7adns8	310	8	of	of	IN
cord-023168-cd7adns8	310	9	vegetables	vegetable	NNS
cord-023168-cd7adns8	310	10	,	,	,
cord-023168-cd7adns8	310	11	and	and	CC
cord-023168-cd7adns8	310	12	malabsorption	malabsorption	NN
cord-023168-cd7adns8	310	13	(	(	-LRB-
cord-023168-cd7adns8	310	14	e.g.	e.g.	JJ
cord-023168-cd7adns8	310	15	abnormalities	abnormality	NNS
cord-023168-cd7adns8	310	16	of	of	IN
cord-023168-cd7adns8	310	17	the	the	DT
cord-023168-cd7adns8	310	18	small	small	JJ
cord-023168-cd7adns8	310	19	bowel	bowel	NN
cord-023168-cd7adns8	310	20	)	)	-RRB-
cord-023168-cd7adns8	310	21	.	.	.
cord-023168-cd7adns8	311	1	Increased	increase	VBN
cord-023168-cd7adns8	311	2	demand	demand	NN
cord-023168-cd7adns8	311	3	for	for	IN
cord-023168-cd7adns8	311	4	folic	folic	JJ
cord-023168-cd7adns8	311	5	acid	acid	NN
cord-023168-cd7adns8	311	6	occurs	occur	VBZ
cord-023168-cd7adns8	311	7	in	in	IN
cord-023168-cd7adns8	311	8	pregnancy	pregnancy	NN
cord-023168-cd7adns8	311	9	because	because	IN
cord-023168-cd7adns8	311	10	the	the	DT
cord-023168-cd7adns8	311	11	growing	grow	VBG
cord-023168-cd7adns8	311	12	foetus	foetus	NN
cord-023168-cd7adns8	311	13	has	have	VBZ
cord-023168-cd7adns8	311	14	a	a	DT
cord-023168-cd7adns8	311	15	high	high	JJ
cord-023168-cd7adns8	311	16	avidity	avidity	NN
cord-023168-cd7adns8	311	17	for	for	IN
cord-023168-cd7adns8	311	18	folate	folate	NN
cord-023168-cd7adns8	311	19	.	.	.
cord-023168-cd7adns8	312	1	For	for	IN
cord-023168-cd7adns8	312	2	this	this	DT
cord-023168-cd7adns8	312	3	reason	reason	NN
cord-023168-cd7adns8	312	4	,	,	,
cord-023168-cd7adns8	312	5	folate	folate	JJ
cord-023168-cd7adns8	312	6	supplementation	supplementation	NN
cord-023168-cd7adns8	312	7	has	have	VBZ
cord-023168-cd7adns8	312	8	been	be	VBN
cord-023168-cd7adns8	312	9	widely	widely	RB
cord-023168-cd7adns8	312	10	recognized	recognize	VBN
cord-023168-cd7adns8	312	11	as	as	IN
cord-023168-cd7adns8	312	12	an	an	DT
cord-023168-cd7adns8	312	13	essential	essential	JJ
cord-023168-cd7adns8	312	14	part	part	NN
cord-023168-cd7adns8	312	15	of	of	IN
cord-023168-cd7adns8	312	16	routine	routine	JJ
cord-023168-cd7adns8	312	17	antenatal	antenatal	JJ
cord-023168-cd7adns8	312	18	care	care	NN
cord-023168-cd7adns8	312	19	to	to	TO
cord-023168-cd7adns8	312	20	reduce	reduce	VB
cord-023168-cd7adns8	312	21	the	the	DT
cord-023168-cd7adns8	312	22	risks	risk	NNS
cord-023168-cd7adns8	312	23	of	of	IN
cord-023168-cd7adns8	312	24	neural	neural	JJ
cord-023168-cd7adns8	312	25	tube	tube	NN
cord-023168-cd7adns8	312	26	defects	defect	NNS
cord-023168-cd7adns8	312	27	.	.	.
cord-023168-cd7adns8	313	1	High	high	JJ
cord-023168-cd7adns8	313	2	folate	folate	NN
cord-023168-cd7adns8	313	3	utilization	utilization	NN
cord-023168-cd7adns8	313	4	also	also	RB
cord-023168-cd7adns8	313	5	occurs	occur	VBZ
cord-023168-cd7adns8	313	6	in	in	IN
cord-023168-cd7adns8	313	7	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	313	8	anaemias	anaemias	NNP
cord-023168-cd7adns8	313	9	such	such	JJ
cord-023168-cd7adns8	313	10	as	as	IN
cord-023168-cd7adns8	313	11	sickle	sickle	NN
cord-023168-cd7adns8	313	12	cell	cell	NN
cord-023168-cd7adns8	313	13	disease	disease	NN
cord-023168-cd7adns8	313	14	due	due	JJ
cord-023168-cd7adns8	313	15	to	to	IN
cord-023168-cd7adns8	313	16	high	high	JJ
cord-023168-cd7adns8	313	17	red	red	JJ
cord-023168-cd7adns8	313	18	cell	cell	NN
cord-023168-cd7adns8	313	19	turnover	turnover	NN
cord-023168-cd7adns8	313	20	and	and	CC
cord-023168-cd7adns8	313	21	exfoliative	exfoliative	JJ
cord-023168-cd7adns8	313	22	dermatitis	dermatitis	NN
cord-023168-cd7adns8	313	23	.	.	.
cord-023168-cd7adns8	314	1	Several	several	JJ
cord-023168-cd7adns8	314	2	drugs	drug	NNS
cord-023168-cd7adns8	314	3	,	,	,
cord-023168-cd7adns8	314	4	including	include	VBG
cord-023168-cd7adns8	314	5	sulfasalazine	sulfasalazine	NN
cord-023168-cd7adns8	314	6	,	,	,
cord-023168-cd7adns8	314	7	trimethoprim	trimethoprim	NNP
cord-023168-cd7adns8	314	8	,	,	,
cord-023168-cd7adns8	314	9	methotrexate	methotrexate	NNP
cord-023168-cd7adns8	314	10	,	,	,
cord-023168-cd7adns8	314	11	pyrimethamine	pyrimethamine	NNP
cord-023168-cd7adns8	314	12	and	and	CC
cord-023168-cd7adns8	314	13	phenytoin	phenytoin	NN
cord-023168-cd7adns8	314	14	,	,	,
cord-023168-cd7adns8	314	15	can	can	MD
cord-023168-cd7adns8	314	16	also	also	RB
cord-023168-cd7adns8	314	17	interfere	interfere	VB
cord-023168-cd7adns8	314	18	with	with	IN
cord-023168-cd7adns8	314	19	folate	folate	JJ
cord-023168-cd7adns8	314	20	metabolism	metabolism	NN
cord-023168-cd7adns8	314	21	.	.	.
cord-023168-cd7adns8	315	1	Folate	folate	NN
cord-023168-cd7adns8	315	2	-	-	HYPH
cord-023168-cd7adns8	315	3	deficient	deficient	JJ
cord-023168-cd7adns8	315	4	individuals	individual	NNS
cord-023168-cd7adns8	315	5	develop	develop	VBP
cord-023168-cd7adns8	315	6	a	a	DT
cord-023168-cd7adns8	315	7	macrocytic	macrocytic	JJ
cord-023168-cd7adns8	315	8	anaemia	anaemia	NN
cord-023168-cd7adns8	315	9	with	with	IN
cord-023168-cd7adns8	315	10	peripheral	peripheral	JJ
cord-023168-cd7adns8	315	11	blood	blood	NN
cord-023168-cd7adns8	315	12	and	and	CC
cord-023168-cd7adns8	315	13	bone	bone	NN
cord-023168-cd7adns8	315	14	marrow	marrow	NN
cord-023168-cd7adns8	315	15	findings	finding	NNS
cord-023168-cd7adns8	315	16	similar	similar	JJ
cord-023168-cd7adns8	315	17	to	to	IN
cord-023168-cd7adns8	315	18	that	that	DT
cord-023168-cd7adns8	315	19	found	find	VBN
cord-023168-cd7adns8	315	20	in	in	IN
cord-023168-cd7adns8	315	21	vitamin	vitamin	NN
cord-023168-cd7adns8	315	22	B	b	NN
cord-023168-cd7adns8	315	23	12	12	CD
cord-023168-cd7adns8	315	24	deficiency	deficiency	NN
cord-023168-cd7adns8	315	25	.	.	.
cord-023168-cd7adns8	316	1	32	32	CD
cord-023168-cd7adns8	316	2	Diagnosis	diagnosis	NN
cord-023168-cd7adns8	316	3	of	of	IN
cord-023168-cd7adns8	316	4	folate	folate	JJ
cord-023168-cd7adns8	316	5	deficiency	deficiency	NN
cord-023168-cd7adns8	316	6	is	be	VBZ
cord-023168-cd7adns8	316	7	confirmed	confirm	VBN
cord-023168-cd7adns8	316	8	by	by	IN
cord-023168-cd7adns8	316	9	the	the	DT
cord-023168-cd7adns8	316	10	presence	presence	NN
cord-023168-cd7adns8	316	11	of	of	IN
cord-023168-cd7adns8	316	12	low	low	JJ
cord-023168-cd7adns8	316	13	serum	serum	NN
cord-023168-cd7adns8	316	14	folate	folate	NN
cord-023168-cd7adns8	316	15	.	.	.
cord-023168-cd7adns8	317	1	Red	red	JJ
cord-023168-cd7adns8	317	2	cell	cell	NN
cord-023168-cd7adns8	317	3	folate	folate	NN
cord-023168-cd7adns8	317	4	levels	level	NNS
cord-023168-cd7adns8	317	5	decrease	decrease	VBP
cord-023168-cd7adns8	317	6	more	more	RBR
cord-023168-cd7adns8	317	7	slowly	slowly	RB
cord-023168-cd7adns8	317	8	than	than	IN
cord-023168-cd7adns8	317	9	serum	serum	NN
cord-023168-cd7adns8	317	10	levels	level	NNS
cord-023168-cd7adns8	317	11	during	during	IN
cord-023168-cd7adns8	317	12	the	the	DT
cord-023168-cd7adns8	317	13	120-day	120-day	JJ
cord-023168-cd7adns8	317	14	turnover	turnover	NN
cord-023168-cd7adns8	317	15	of	of	IN
cord-023168-cd7adns8	317	16	the	the	DT
cord-023168-cd7adns8	317	17	red	red	JJ
cord-023168-cd7adns8	317	18	cells	cell	NNS
cord-023168-cd7adns8	317	19	.	.	.
cord-023168-cd7adns8	318	1	Red	red	JJ
cord-023168-cd7adns8	318	2	cell	cell	NN
cord-023168-cd7adns8	318	3	folate	folate	NN
cord-023168-cd7adns8	318	4	levels	level	NNS
cord-023168-cd7adns8	318	5	may	may	MD
cord-023168-cd7adns8	318	6	be	be	VB
cord-023168-cd7adns8	318	7	a	a	DT
cord-023168-cd7adns8	318	8	better	well	JJR
cord-023168-cd7adns8	318	9	indicator	indicator	NN
cord-023168-cd7adns8	318	10	of	of	IN
cord-023168-cd7adns8	318	11	tissue	tissue	NN
cord-023168-cd7adns8	318	12	folate	folate	NN
cord-023168-cd7adns8	318	13	levels	level	NNS
cord-023168-cd7adns8	318	14	than	than	IN
cord-023168-cd7adns8	318	15	serum	serum	NN
cord-023168-cd7adns8	318	16	folate	folate	NN
cord-023168-cd7adns8	318	17	,	,	,
cord-023168-cd7adns8	318	18	although	although	IN
cord-023168-cd7adns8	318	19	red	red	JJ
cord-023168-cd7adns8	318	20	cell	cell	NN
cord-023168-cd7adns8	318	21	folate	folate	NN
cord-023168-cd7adns8	318	22	can	can	MD
cord-023168-cd7adns8	318	23	be	be	VB
cord-023168-cd7adns8	318	24	more	more	RBR
cord-023168-cd7adns8	318	25	expensive	expensive	JJ
cord-023168-cd7adns8	318	26	and	and	CC
cord-023168-cd7adns8	318	27	falsely	falsely	RB
cord-023168-cd7adns8	318	28	low	low	JJ
cord-023168-cd7adns8	318	29	in	in	IN
cord-023168-cd7adns8	318	30	vitamin	vitamin	NN
cord-023168-cd7adns8	318	31	B	b	NN
cord-023168-cd7adns8	318	32	12	12	CD
cord-023168-cd7adns8	318	33	deficiency	deficiency	NN
cord-023168-cd7adns8	318	34	.	.	.
cord-023168-cd7adns8	319	1	45	45	CD
cord-023168-cd7adns8	319	2	,	,	,
cord-023168-cd7adns8	319	3	44	44	CD
cord-023168-cd7adns8	319	4	Treatment	treatment	NN
cord-023168-cd7adns8	319	5	of	of	IN
cord-023168-cd7adns8	319	6	folate	folate	JJ
cord-023168-cd7adns8	319	7	deficiency	deficiency	NN
cord-023168-cd7adns8	319	8	is	be	VBZ
cord-023168-cd7adns8	319	9	with	with	IN
cord-023168-cd7adns8	319	10	oral	oral	JJ
cord-023168-cd7adns8	319	11	folate	folate	NN
cord-023168-cd7adns8	319	12	(	(	-LRB-
cord-023168-cd7adns8	319	13	5	5	CD
cord-023168-cd7adns8	319	14	mg	mg	NNP
cord-023168-cd7adns8	319	15	daily	daily	NN
cord-023168-cd7adns8	319	16	)	)	-RRB-
cord-023168-cd7adns8	319	17	which	which	WDT
cord-023168-cd7adns8	319	18	is	be	VBZ
cord-023168-cd7adns8	319	19	sufficient	sufficient	JJ
cord-023168-cd7adns8	319	20	even	even	RB
cord-023168-cd7adns8	319	21	in	in	IN
cord-023168-cd7adns8	319	22	malabsorptive	malabsorptive	JJ
cord-023168-cd7adns8	319	23	states	state	NNS
cord-023168-cd7adns8	319	24	.	.	.
cord-023168-cd7adns8	320	1	It	-PRON-	PRP
cord-023168-cd7adns8	320	2	is	be	VBZ
cord-023168-cd7adns8	320	3	crucial	crucial	JJ
cord-023168-cd7adns8	320	4	that	that	IN
cord-023168-cd7adns8	320	5	any	any	DT
cord-023168-cd7adns8	320	6	co	co	JJ
cord-023168-cd7adns8	320	7	-	-	JJ
cord-023168-cd7adns8	320	8	existing	existing	JJ
cord-023168-cd7adns8	320	9	vitamin	vitamin	NN
cord-023168-cd7adns8	320	10	B	b	NN
cord-023168-cd7adns8	320	11	12	12	CD
cord-023168-cd7adns8	320	12	deficiency	deficiency	NN
cord-023168-cd7adns8	320	13	is	be	VBZ
cord-023168-cd7adns8	320	14	ruled	rule	VBN
cord-023168-cd7adns8	320	15	out	out	RP
cord-023168-cd7adns8	320	16	before	before	IN
cord-023168-cd7adns8	320	17	initiating	initiate	VBG
cord-023168-cd7adns8	320	18	folic	folic	JJ
cord-023168-cd7adns8	320	19	acid	acid	NN
cord-023168-cd7adns8	320	20	therapy	therapy	NN
cord-023168-cd7adns8	320	21	,	,	,
cord-023168-cd7adns8	320	22	otherwise	otherwise	RB
cord-023168-cd7adns8	320	23	the	the	DT
cord-023168-cd7adns8	320	24	neurological	neurological	JJ
cord-023168-cd7adns8	320	25	manifestations	manifestation	NNS
cord-023168-cd7adns8	320	26	of	of	IN
cord-023168-cd7adns8	320	27	B	b	NN
cord-023168-cd7adns8	320	28	12	12	CD
cord-023168-cd7adns8	320	29	deficiency	deficiency	NN
cord-023168-cd7adns8	320	30	may	may	MD
cord-023168-cd7adns8	320	31	deteriorate	deteriorate	VB
cord-023168-cd7adns8	320	32	rapidly	rapidly	RB
cord-023168-cd7adns8	320	33	.	.	.
cord-023168-cd7adns8	321	1	It	-PRON-	PRP
cord-023168-cd7adns8	321	2	is	be	VBZ
cord-023168-cd7adns8	321	3	also	also	RB
cord-023168-cd7adns8	321	4	important	important	JJ
cord-023168-cd7adns8	321	5	increasingly	increasingly	RB
cord-023168-cd7adns8	321	6	popular	popular	JJ
cord-023168-cd7adns8	321	7	oral	oral	JJ
cord-023168-cd7adns8	321	8	replacement	replacement	NN
cord-023168-cd7adns8	321	9	therapies	therapy	NNS
cord-023168-cd7adns8	321	10	.	.	.
cord-023168-cd7adns8	322	1	Once	once	RB
cord-023168-cd7adns8	322	2	absorbed	absorb	VBN
cord-023168-cd7adns8	322	3	,	,	,
cord-023168-cd7adns8	322	4	vitamin	vitamin	NN
cord-023168-cd7adns8	322	5	B	b	NN
cord-023168-cd7adns8	322	6	12	12	CD
cord-023168-cd7adns8	322	7	binds	bind	NNS
cord-023168-cd7adns8	322	8	to	to	IN
cord-023168-cd7adns8	322	9	transcobalamin	transcobalamin	NNP
cord-023168-cd7adns8	322	10	II	II	NNP
cord-023168-cd7adns8	322	11	to	to	TO
cord-023168-cd7adns8	322	12	be	be	VB
cord-023168-cd7adns8	322	13	transported	transport	VBN
cord-023168-cd7adns8	322	14	around	around	IN
cord-023168-cd7adns8	322	15	the	the	DT
cord-023168-cd7adns8	322	16	body	body	NN
cord-023168-cd7adns8	322	17	.	.	.
cord-023168-cd7adns8	323	1	The	the	DT
cord-023168-cd7adns8	323	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	323	3	of	of	IN
cord-023168-cd7adns8	323	4	vitamin	vitamin	NN
cord-023168-cd7adns8	323	5	B	b	NN
cord-023168-cd7adns8	323	6	12	12	CD
cord-023168-cd7adns8	323	7	deficiency	deficiency	NN
cord-023168-cd7adns8	323	8	is	be	VBZ
cord-023168-cd7adns8	323	9	based	base	VBN
cord-023168-cd7adns8	323	10	on	on	IN
cord-023168-cd7adns8	323	11	the	the	DT
cord-023168-cd7adns8	323	12	measurement	measurement	NN
cord-023168-cd7adns8	323	13	of	of	IN
cord-023168-cd7adns8	323	14	serum	serum	NN
cord-023168-cd7adns8	323	15	vitamin	vitamin	NN
cord-023168-cd7adns8	323	16	levels	level	NNS
cord-023168-cd7adns8	323	17	in	in	IN
cord-023168-cd7adns8	323	18	a	a	DT
cord-023168-cd7adns8	323	19	patient	patient	NN
cord-023168-cd7adns8	323	20	with	with	IN
cord-023168-cd7adns8	323	21	clinical	clinical	JJ
cord-023168-cd7adns8	323	22	evidence	evidence	NN
cord-023168-cd7adns8	323	23	of	of	IN
cord-023168-cd7adns8	323	24	deficiency	deficiency	NN
cord-023168-cd7adns8	323	25	.	.	.
cord-023168-cd7adns8	324	1	A	a	DT
cord-023168-cd7adns8	324	2	note	note	NN
cord-023168-cd7adns8	324	3	of	of	IN
cord-023168-cd7adns8	324	4	caution	caution	NN
cord-023168-cd7adns8	324	5	is	be	VBZ
cord-023168-cd7adns8	324	6	that	that	IN
cord-023168-cd7adns8	324	7	folic	folic	JJ
cord-023168-cd7adns8	324	8	acid	acid	JJ
cord-023168-cd7adns8	324	9	deficiency	deficiency	NN
cord-023168-cd7adns8	324	10	can	can	MD
cord-023168-cd7adns8	324	11	cause	cause	VB
cord-023168-cd7adns8	324	12	falsely	falsely	RB
cord-023168-cd7adns8	324	13	low	low	JJ
cord-023168-cd7adns8	324	14	serum	serum	NN
cord-023168-cd7adns8	324	15	vitamin	vitamin	NN
cord-023168-cd7adns8	324	16	B	b	NN
cord-023168-cd7adns8	324	17	12	12	CD
cord-023168-cd7adns8	324	18	levels	level	NNS
cord-023168-cd7adns8	324	19	.	.	.
cord-023168-cd7adns8	325	1	Diagnostic	diagnostic	JJ
cord-023168-cd7adns8	325	2	clues	clue	NNS
cord-023168-cd7adns8	325	3	for	for	IN
cord-023168-cd7adns8	325	4	vitamin	vitamin	NN
cord-023168-cd7adns8	325	5	B	b	NN
cord-023168-cd7adns8	325	6	12	12	CD
cord-023168-cd7adns8	325	7	deficiency	deficiency	NN
cord-023168-cd7adns8	325	8	include	include	VBP
cord-023168-cd7adns8	325	9	marked	mark	VBN
cord-023168-cd7adns8	325	10	macrocytosis	macrocytosis	NN
cord-023168-cd7adns8	325	11	(	(	-LRB-
cord-023168-cd7adns8	325	12	often	often	RB
cord-023168-cd7adns8	325	13	>	>	NFP
cord-023168-cd7adns8	325	14	130	130	CD
cord-023168-cd7adns8	325	15	fl	fl	NNP
cord-023168-cd7adns8	325	16	)	)	-RRB-
cord-023168-cd7adns8	325	17	,	,	,
cord-023168-cd7adns8	325	18	neutrophil	neutrophil	NN
cord-023168-cd7adns8	325	19	nuclear	nuclear	JJ
cord-023168-cd7adns8	325	20	hypersegmentation	hypersegmentation	NN
cord-023168-cd7adns8	325	21	and	and	CC
cord-023168-cd7adns8	325	22	oval	oval	JJ
cord-023168-cd7adns8	325	23	macrocytes	macrocyte	NNS
cord-023168-cd7adns8	325	24	in	in	IN
cord-023168-cd7adns8	325	25	the	the	DT
cord-023168-cd7adns8	325	26	peripheral	peripheral	JJ
cord-023168-cd7adns8	325	27	blood	blood	NN
cord-023168-cd7adns8	325	28	film	film	NN
cord-023168-cd7adns8	325	29	.	.	.
cord-023168-cd7adns8	326	1	Blood	blood	NN
cord-023168-cd7adns8	326	2	tests	test	NNS
cord-023168-cd7adns8	326	3	may	may	MD
cord-023168-cd7adns8	326	4	demonstrate	demonstrate	VB
cord-023168-cd7adns8	326	5	increased	increase	VBN
cord-023168-cd7adns8	326	6	lactate	lactate	NN
cord-023168-cd7adns8	326	7	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	326	8	and	and	CC
cord-023168-cd7adns8	326	9	low	low	JJ
cord-023168-cd7adns8	326	10	haptoglobin	haptoglobin	NN
cord-023168-cd7adns8	326	11	levels	level	NNS
cord-023168-cd7adns8	326	12	due	due	JJ
cord-023168-cd7adns8	326	13	to	to	IN
cord-023168-cd7adns8	326	14	haemolysis	haemolysis	NN
cord-023168-cd7adns8	326	15	within	within	IN
cord-023168-cd7adns8	326	16	the	the	DT
cord-023168-cd7adns8	326	17	bone	bone	NN
cord-023168-cd7adns8	326	18	marrow	marrow	NN
cord-023168-cd7adns8	326	19	.	.	.
cord-023168-cd7adns8	327	1	The	the	DT
cord-023168-cd7adns8	327	2	cause	cause	NN
cord-023168-cd7adns8	327	3	of	of	IN
cord-023168-cd7adns8	327	4	the	the	DT
cord-023168-cd7adns8	327	5	macrocytosis	macrocytosis	NN
cord-023168-cd7adns8	327	6	can	can	MD
cord-023168-cd7adns8	327	7	be	be	VB
cord-023168-cd7adns8	327	8	confirmed	confirm	VBN
cord-023168-cd7adns8	327	9	by	by	IN
cord-023168-cd7adns8	327	10	bone	bone	NN
cord-023168-cd7adns8	327	11	marrow	marrow	NN
cord-023168-cd7adns8	327	12	examination	examination	NN
cord-023168-cd7adns8	327	13	which	which	WDT
cord-023168-cd7adns8	327	14	reveals	reveal	VBZ
cord-023168-cd7adns8	327	15	a	a	DT
cord-023168-cd7adns8	327	16	megaloblastic	megaloblastic	JJ
cord-023168-cd7adns8	327	17	picture	picture	NN
cord-023168-cd7adns8	327	18	.	.	.
cord-023168-cd7adns8	328	1	Although	although	IN
cord-023168-cd7adns8	328	2	macrocytic	macrocytic	JJ
cord-023168-cd7adns8	328	3	anaemia	anaemia	NN
cord-023168-cd7adns8	328	4	is	be	VBZ
cord-023168-cd7adns8	328	5	a	a	DT
cord-023168-cd7adns8	328	6	typical	typical	JJ
cord-023168-cd7adns8	328	7	feature	feature	NN
cord-023168-cd7adns8	328	8	of	of	IN
cord-023168-cd7adns8	328	9	vitamin	vitamin	NN
cord-023168-cd7adns8	328	10	B	b	NN
cord-023168-cd7adns8	328	11	12	12	CD
cord-023168-cd7adns8	328	12	deficiency	deficiency	NN
cord-023168-cd7adns8	328	13	,	,	,
cord-023168-cd7adns8	328	14	it	-PRON-	PRP
cord-023168-cd7adns8	328	15	can	can	MD
cord-023168-cd7adns8	328	16	be	be	VB
cord-023168-cd7adns8	328	17	absent	absent	JJ
cord-023168-cd7adns8	328	18	in	in	IN
cord-023168-cd7adns8	328	19	older	old	JJR
cord-023168-cd7adns8	328	20	individuals	individual	NNS
cord-023168-cd7adns8	328	21	who	who	WP
cord-023168-cd7adns8	328	22	may	may	MD
cord-023168-cd7adns8	328	23	only	only	RB
cord-023168-cd7adns8	328	24	have	have	VB
cord-023168-cd7adns8	328	25	neuropsychiatric	neuropsychiatric	JJ
cord-023168-cd7adns8	328	26	features	feature	NNS
cord-023168-cd7adns8	328	27	.	.	.
cord-023168-cd7adns8	329	1	Measurements	measurement	NNS
cord-023168-cd7adns8	329	2	of	of	IN
cord-023168-cd7adns8	329	3	methylmalonic	methylmalonic	NNP
cord-023168-cd7adns8	329	4	acid	acid	NN
cord-023168-cd7adns8	329	5	and	and	CC
cord-023168-cd7adns8	329	6	homocysteine	homocysteine	NN
cord-023168-cd7adns8	329	7	levels	level	NNS
cord-023168-cd7adns8	329	8	,	,	,
cord-023168-cd7adns8	329	9	two	two	CD
cord-023168-cd7adns8	329	10	markers	marker	NNS
cord-023168-cd7adns8	329	11	which	which	WDT
cord-023168-cd7adns8	329	12	are	be	VBP
cord-023168-cd7adns8	329	13	very	very	RB
cord-023168-cd7adns8	329	14	sensitive	sensitive	JJ
cord-023168-cd7adns8	329	15	for	for	IN
cord-023168-cd7adns8	329	16	detecting	detect	VBG
cord-023168-cd7adns8	329	17	B	b	NN
cord-023168-cd7adns8	329	18	12	12	CD
cord-023168-cd7adns8	329	19	deficiency	deficiency	NN
cord-023168-cd7adns8	329	20	,	,	,
cord-023168-cd7adns8	329	21	have	have	VBP
cord-023168-cd7adns8	329	22	shown	show	VBN
cord-023168-cd7adns8	329	23	that	that	DT
cord-023168-cd7adns8	329	24	vitamin	vitamin	NN
cord-023168-cd7adns8	329	25	B	b	NN
cord-023168-cd7adns8	329	26	12	12	CD
cord-023168-cd7adns8	329	27	deficiency	deficiency	NN
cord-023168-cd7adns8	329	28	can	can	MD
cord-023168-cd7adns8	329	29	occur	occur	VB
cord-023168-cd7adns8	329	30	with	with	IN
cord-023168-cd7adns8	329	31	normal	normal	JJ
cord-023168-cd7adns8	329	32	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	329	33	levels	level	NNS
cord-023168-cd7adns8	329	34	and	and	CC
cord-023168-cd7adns8	329	35	without	without	IN
cord-023168-cd7adns8	329	36	macrocytosis	macrocytosis	NN
cord-023168-cd7adns8	329	37	.	.	.
cord-023168-cd7adns8	330	1	36	36	CD
cord-023168-cd7adns8	330	2	Pernicious	pernicious	JJ
cord-023168-cd7adns8	330	3	anaemia	anaemia	NN
cord-023168-cd7adns8	330	4	is	be	VBZ
cord-023168-cd7adns8	330	5	probably	probably	RB
cord-023168-cd7adns8	330	6	the	the	DT
cord-023168-cd7adns8	330	7	commonest	common	JJS
cord-023168-cd7adns8	330	8	cause	cause	NN
cord-023168-cd7adns8	330	9	of	of	IN
cord-023168-cd7adns8	330	10	vitamin	vitamin	NN
cord-023168-cd7adns8	330	11	B	b	NN
cord-023168-cd7adns8	330	12	12	12	CD
cord-023168-cd7adns8	330	13	deficiency	deficiency	NN
cord-023168-cd7adns8	330	14	.	.	.
cord-023168-cd7adns8	331	1	The	the	DT
cord-023168-cd7adns8	331	2	presence	presence	NN
cord-023168-cd7adns8	331	3	of	of	IN
cord-023168-cd7adns8	331	4	parietal	parietal	JJ
cord-023168-cd7adns8	331	5	cell	cell	NN
cord-023168-cd7adns8	331	6	or	or	CC
cord-023168-cd7adns8	331	7	intrinsic	intrinsic	JJ
cord-023168-cd7adns8	331	8	factor	factor	NN
cord-023168-cd7adns8	331	9	antibodies	antibody	NNS
cord-023168-cd7adns8	331	10	supports	support	VBZ
cord-023168-cd7adns8	331	11	a	a	DT
cord-023168-cd7adns8	331	12	diagnosis	diagnosis	NN
cord-023168-cd7adns8	331	13	of	of	IN
cord-023168-cd7adns8	331	14	pernicious	pernicious	JJ
cord-023168-cd7adns8	331	15	anaemia	anaemia	NN
cord-023168-cd7adns8	331	16	.	.	.
cord-023168-cd7adns8	332	1	[	[	-LRB-
cord-023168-cd7adns8	332	2	33	33	CD
cord-023168-cd7adns8	332	3	]	]	-RRB-
cord-023168-cd7adns8	332	4	[	[	-LRB-
cord-023168-cd7adns8	332	5	34	34	CD
cord-023168-cd7adns8	332	6	]	]	-RRB-
cord-023168-cd7adns8	332	7	[	[	-LRB-
cord-023168-cd7adns8	332	8	35	35	CD
cord-023168-cd7adns8	332	9	]	]	-RRB-
cord-023168-cd7adns8	332	10	[	[	-LRB-
cord-023168-cd7adns8	332	11	36	36	CD
cord-023168-cd7adns8	332	12	]	]	-RRB-
cord-023168-cd7adns8	333	1	Schilling	Schilling	NNP
cord-023168-cd7adns8	333	2	tests	test	NNS
cord-023168-cd7adns8	333	3	are	be	VBP
cord-023168-cd7adns8	333	4	rarely	rarely	RB
cord-023168-cd7adns8	333	5	performed	perform	VBN
cord-023168-cd7adns8	333	6	because	because	IN
cord-023168-cd7adns8	333	7	of	of	IN
cord-023168-cd7adns8	333	8	the	the	DT
cord-023168-cd7adns8	333	9	unavailability	unavailability	NN
cord-023168-cd7adns8	333	10	of	of	IN
cord-023168-cd7adns8	333	11	the	the	DT
cord-023168-cd7adns8	333	12	radio	radio	NN
cord-023168-cd7adns8	333	13	-	-	HYPH
cord-023168-cd7adns8	333	14	labelled	label	VBN
cord-023168-cd7adns8	333	15	vitamin	vitamin	NN
cord-023168-cd7adns8	333	16	B	b	NN
cord-023168-cd7adns8	333	17	12	12	CD
cord-023168-cd7adns8	333	18	and	and	CC
cord-023168-cd7adns8	333	19	the	the	DT
cord-023168-cd7adns8	333	20	difficulty	difficulty	NN
cord-023168-cd7adns8	333	21	in	in	IN
cord-023168-cd7adns8	333	22	interpreting	interpret	VBG
cord-023168-cd7adns8	333	23	the	the	DT
cord-023168-cd7adns8	333	24	results	result	NNS
cord-023168-cd7adns8	333	25	in	in	IN
cord-023168-cd7adns8	333	26	the	the	DT
cord-023168-cd7adns8	333	27	presence	presence	NN
cord-023168-cd7adns8	333	28	of	of	IN
cord-023168-cd7adns8	333	29	renal	renal	JJ
cord-023168-cd7adns8	333	30	insufficiency	insufficiency	NN
cord-023168-cd7adns8	333	31	.	.	.
cord-023168-cd7adns8	333	32	 	 	_SP
cord-023168-cd7adns8	334	1	•	•	NNP
cord-023168-cd7adns8	335	1	Pernicious	pernicious	JJ
cord-023168-cd7adns8	335	2	anaemia	anaemia	NN
cord-023168-cd7adns8	335	3	(	(	-LRB-
cord-023168-cd7adns8	335	4	begins	begin	VBZ
cord-023168-cd7adns8	335	5	after	after	IN
cord-023168-cd7adns8	335	6	40	40	CD
cord-023168-cd7adns8	335	7	)	)	-RRB-
cord-023168-cd7adns8	335	8	,	,	,
cord-023168-cd7adns8	335	9	increased	increase	VBN
cord-023168-cd7adns8	335	10	risk	risk	NN
cord-023168-cd7adns8	335	11	of	of	IN
cord-023168-cd7adns8	335	12	gastric	gastric	JJ
cord-023168-cd7adns8	335	13	carcinoma	carcinoma	NN
cord-023168-cd7adns8	335	14	and	and	CC
cord-023168-cd7adns8	335	15	carcinoid	carcinoid	NN
cord-023168-cd7adns8	335	16	tumours	tumour	NNS
cord-023168-cd7adns8	336	1	•	•	NNP
cord-023168-cd7adns8	337	1	Rare	rare	JJ
cord-023168-cd7adns8	337	2	congenital	congenital	JJ
cord-023168-cd7adns8	337	3	disorders	disorder	NNS
cord-023168-cd7adns8	337	4	,	,	,
cord-023168-cd7adns8	337	5	e.g.	e.g.	RB
cord-023168-cd7adns8	337	6	Imerslund	Imerslund	NNP
cord-023168-cd7adns8	337	7	-	-	HYPH
cord-023168-cd7adns8	337	8	Grasbeck	Grasbeck	NNP
cord-023168-cd7adns8	337	9	syndrome	syndrome	NN
cord-023168-cd7adns8	337	10	.	.	.
cord-023168-cd7adns8	338	1	The	the	DT
cord-023168-cd7adns8	338	2	neglected	neglected	JJ
cord-023168-cd7adns8	338	3	tropical	tropical	JJ
cord-023168-cd7adns8	338	4	diseases	disease	NNS
cord-023168-cd7adns8	338	5	are	be	VBP
cord-023168-cd7adns8	338	6	a	a	DT
cord-023168-cd7adns8	338	7	group	group	NN
cord-023168-cd7adns8	338	8	of	of	IN
cord-023168-cd7adns8	338	9	infections	infection	NNS
cord-023168-cd7adns8	338	10	which	which	WDT
cord-023168-cd7adns8	338	11	are	be	VBP
cord-023168-cd7adns8	338	12	endemic	endemic	JJ
cord-023168-cd7adns8	338	13	in	in	IN
cord-023168-cd7adns8	338	14	developing	develop	VBG
cord-023168-cd7adns8	338	15	countries	country	NNS
cord-023168-cd7adns8	338	16	.	.	.
cord-023168-cd7adns8	339	1	Several	several	JJ
cord-023168-cd7adns8	339	2	of	of	IN
cord-023168-cd7adns8	339	3	these	these	DT
cord-023168-cd7adns8	339	4	neglected	neglect	VBN
cord-023168-cd7adns8	339	5	tropical	tropical	JJ
cord-023168-cd7adns8	339	6	diseases	disease	NNS
cord-023168-cd7adns8	339	7	cause	cause	VBP
cord-023168-cd7adns8	339	8	anaemia	anaemia	NN
cord-023168-cd7adns8	339	9	and	and	CC
cord-023168-cd7adns8	339	10	many	many	JJ
cord-023168-cd7adns8	339	11	can	can	MD
cord-023168-cd7adns8	339	12	be	be	VB
cord-023168-cd7adns8	339	13	managed	manage	VBN
cord-023168-cd7adns8	339	14	using	use	VBG
cord-023168-cd7adns8	339	15	inexpensive	inexpensive	JJ
cord-023168-cd7adns8	339	16	interventions	intervention	NNS
cord-023168-cd7adns8	339	17	to	to	TO
cord-023168-cd7adns8	339	18	treat	treat	VB
cord-023168-cd7adns8	339	19	the	the	DT
cord-023168-cd7adns8	339	20	underlying	underlying	JJ
cord-023168-cd7adns8	339	21	parasitic	parasitic	JJ
cord-023168-cd7adns8	339	22	infections	infection	NNS
cord-023168-cd7adns8	339	23	.	.	.
cord-023168-cd7adns8	340	1	14	14	CD
cord-023168-cd7adns8	341	1	The	the	DT
cord-023168-cd7adns8	341	2	mechanisms	mechanism	NNS
cord-023168-cd7adns8	341	3	of	of	IN
cord-023168-cd7adns8	341	4	anaemia	anaemia	NN
cord-023168-cd7adns8	341	5	in	in	IN
cord-023168-cd7adns8	341	6	these	these	DT
cord-023168-cd7adns8	341	7	conditions	condition	NNS
cord-023168-cd7adns8	341	8	are	be	VBP
cord-023168-cd7adns8	341	9	predominantly	predominantly	RB
cord-023168-cd7adns8	341	10	blood	blood	NN
cord-023168-cd7adns8	341	11	loss	loss	NN
cord-023168-cd7adns8	341	12	from	from	IN
cord-023168-cd7adns8	341	13	the	the	DT
cord-023168-cd7adns8	341	14	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	341	15	or	or	CC
cord-023168-cd7adns8	341	16	genitourinary	genitourinary	JJ
cord-023168-cd7adns8	341	17	tracts	tract	NNS
cord-023168-cd7adns8	341	18	but	but	CC
cord-023168-cd7adns8	341	19	also	also	RB
cord-023168-cd7adns8	341	20	poor	poor	JJ
cord-023168-cd7adns8	341	21	nutrition	nutrition	NN
cord-023168-cd7adns8	341	22	,	,	,
cord-023168-cd7adns8	341	23	bone	bone	NN
cord-023168-cd7adns8	341	24	marrow	marrow	NN
cord-023168-cd7adns8	341	25	suppression	suppression	NN
cord-023168-cd7adns8	341	26	,	,	,
cord-023168-cd7adns8	341	27	inflammation	inflammation	NN
cord-023168-cd7adns8	341	28	,	,	,
cord-023168-cd7adns8	341	29	hypersplenism	hypersplenism	NNP
cord-023168-cd7adns8	341	30	and	and	CC
cord-023168-cd7adns8	341	31	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	341	32	.	.	.
cord-023168-cd7adns8	342	1	58	58	CD
cord-023168-cd7adns8	342	2	Anaemia	anaemia	NN
cord-023168-cd7adns8	342	3	is	be	VBZ
cord-023168-cd7adns8	342	4	a	a	DT
cord-023168-cd7adns8	342	5	common	common	JJ
cord-023168-cd7adns8	342	6	consequence	consequence	NN
cord-023168-cd7adns8	342	7	of	of	IN
cord-023168-cd7adns8	342	8	infections	infection	NNS
cord-023168-cd7adns8	342	9	with	with	IN
cord-023168-cd7adns8	342	10	soiltransmitted	soiltransmitted	JJ
cord-023168-cd7adns8	342	11	helminths	helminth	NNS
cord-023168-cd7adns8	342	12	or	or	CC
cord-023168-cd7adns8	342	13	schistosoma	schistosoma	NN
cord-023168-cd7adns8	342	14	with	with	IN
cord-023168-cd7adns8	342	15	a	a	DT
cord-023168-cd7adns8	342	16	strong	strong	JJ
cord-023168-cd7adns8	342	17	correlation	correlation	NN
cord-023168-cd7adns8	342	18	between	between	IN
cord-023168-cd7adns8	342	19	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	342	20	level	level	NN
cord-023168-cd7adns8	342	21	and	and	CC
cord-023168-cd7adns8	342	22	worm	worm	NN
cord-023168-cd7adns8	342	23	load	load	NN
cord-023168-cd7adns8	342	24	or	or	CC
cord-023168-cd7adns8	342	25	faecal	faecal	JJ
cord-023168-cd7adns8	342	26	egg	egg	NN
cord-023168-cd7adns8	342	27	count	count	NN
cord-023168-cd7adns8	342	28	.	.	.
cord-023168-cd7adns8	343	1	Even	even	RB
cord-023168-cd7adns8	343	2	mild	mild	JJ
cord-023168-cd7adns8	343	3	infections	infection	NNS
cord-023168-cd7adns8	343	4	can	can	MD
cord-023168-cd7adns8	343	5	lead	lead	VB
cord-023168-cd7adns8	343	6	to	to	IN
cord-023168-cd7adns8	343	7	anaemia	anaemia	NN
cord-023168-cd7adns8	343	8	.	.	.
cord-023168-cd7adns8	344	1	59	59	CD
cord-023168-cd7adns8	344	2	Polyparasitism	Polyparasitism	NNP
cord-023168-cd7adns8	344	3	(	(	-LRB-
cord-023168-cd7adns8	344	4	i.e.	i.e.	FW
cord-023168-cd7adns8	344	5	infection	infection	NN
cord-023168-cd7adns8	344	6	with	with	IN
cord-023168-cd7adns8	344	7	several	several	JJ
cord-023168-cd7adns8	344	8	parasites	parasite	NNS
cord-023168-cd7adns8	344	9	simultaneously	simultaneously	RB
cord-023168-cd7adns8	344	10	)	)	-RRB-
cord-023168-cd7adns8	344	11	can	can	MD
cord-023168-cd7adns8	344	12	be	be	VB
cord-023168-cd7adns8	344	13	responsible	responsible	JJ
cord-023168-cd7adns8	344	14	for	for	IN
cord-023168-cd7adns8	344	15	unresponsiveness	unresponsiveness	NN
cord-023168-cd7adns8	344	16	of	of	IN
cord-023168-cd7adns8	344	17	the	the	DT
cord-023168-cd7adns8	344	18	anaemia	anaemia	NN
cord-023168-cd7adns8	344	19	to	to	IN
cord-023168-cd7adns8	344	20	eradication	eradication	NN
cord-023168-cd7adns8	344	21	of	of	IN
cord-023168-cd7adns8	344	22	one	one	CD
cord-023168-cd7adns8	344	23	organism	organism	NN
cord-023168-cd7adns8	344	24	.	.	.
cord-023168-cd7adns8	345	1	60	60	CD
cord-023168-cd7adns8	345	2	Treatment	treatment	NN
cord-023168-cd7adns8	345	3	of	of	IN
cord-023168-cd7adns8	345	4	communities	community	NNS
cord-023168-cd7adns8	345	5	at	at	IN
cord-023168-cd7adns8	345	6	high	high	JJ
cord-023168-cd7adns8	345	7	risk	risk	NN
cord-023168-cd7adns8	345	8	of	of	IN
cord-023168-cd7adns8	345	9	soiltransmitted	soiltransmitted	JJ
cord-023168-cd7adns8	345	10	helminths	helminth	NNS
cord-023168-cd7adns8	345	11	improves	improve	VBZ
cord-023168-cd7adns8	345	12	growth	growth	NN
cord-023168-cd7adns8	345	13	and	and	CC
cord-023168-cd7adns8	345	14	iron	iron	NN
cord-023168-cd7adns8	345	15	stores	store	NNS
cord-023168-cd7adns8	345	16	in	in	IN
cord-023168-cd7adns8	345	17	children	child	NNS
cord-023168-cd7adns8	345	18	and	and	CC
cord-023168-cd7adns8	345	19	reduces	reduce	VBZ
cord-023168-cd7adns8	345	20	anaemia	anaemia	NN
cord-023168-cd7adns8	345	21	in	in	IN
cord-023168-cd7adns8	345	22	pregnant	pregnant	JJ
cord-023168-cd7adns8	345	23	women	woman	NNS
cord-023168-cd7adns8	345	24	.	.	.
cord-023168-cd7adns8	346	1	61	61	CD
cord-023168-cd7adns8	347	1	The	the	DT
cord-023168-cd7adns8	347	2	treatment	treatment	NN
cord-023168-cd7adns8	347	3	of	of	IN
cord-023168-cd7adns8	347	4	anaemia	anaemia	NN
cord-023168-cd7adns8	347	5	due	due	JJ
cord-023168-cd7adns8	347	6	to	to	IN
cord-023168-cd7adns8	347	7	neglected	neglect	VBN
cord-023168-cd7adns8	347	8	tropical	tropical	JJ
cord-023168-cd7adns8	347	9	diseases	disease	NNS
cord-023168-cd7adns8	347	10	depends	depend	VBZ
cord-023168-cd7adns8	347	11	on	on	IN
cord-023168-cd7adns8	347	12	eradication	eradication	NN
cord-023168-cd7adns8	347	13	of	of	IN
cord-023168-cd7adns8	347	14	the	the	DT
cord-023168-cd7adns8	347	15	parasite	parasite	NN
cord-023168-cd7adns8	347	16	with	with	IN
cord-023168-cd7adns8	347	17	drugs	drug	NNS
cord-023168-cd7adns8	347	18	such	such	JJ
cord-023168-cd7adns8	347	19	as	as	IN
cord-023168-cd7adns8	347	20	albendazole	albendazole	NN
cord-023168-cd7adns8	347	21	and	and	CC
cord-023168-cd7adns8	347	22	praziquantel	praziquantel	NN
cord-023168-cd7adns8	347	23	though	though	IN
cord-023168-cd7adns8	347	24	anaemia	anaemia	NN
cord-023168-cd7adns8	347	25	resolution	resolution	NN
cord-023168-cd7adns8	347	26	may	may	MD
cord-023168-cd7adns8	347	27	be	be	VB
cord-023168-cd7adns8	347	28	less	less	RBR
cord-023168-cd7adns8	347	29	successful	successful	JJ
cord-023168-cd7adns8	347	30	if	if	IN
cord-023168-cd7adns8	347	31	it	-PRON-	PRP
cord-023168-cd7adns8	347	32	is	be	VBZ
cord-023168-cd7adns8	347	33	due	due	JJ
cord-023168-cd7adns8	347	34	to	to	IN
cord-023168-cd7adns8	347	35	trichuriasis	trichuriasis	NNP
cord-023168-cd7adns8	347	36	.	.	.
cord-023168-cd7adns8	348	1	62	62	CD
cord-023168-cd7adns8	348	2	-	-	SYM
cord-023168-cd7adns8	348	3	64	64	CD
cord-023168-cd7adns8	349	1	The	the	DT
cord-023168-cd7adns8	349	2	addition	addition	NN
cord-023168-cd7adns8	349	3	of	of	IN
cord-023168-cd7adns8	349	4	iron	iron	NN
cord-023168-cd7adns8	349	5	to	to	IN
cord-023168-cd7adns8	349	6	anthelmintic	anthelmintic	JJ
cord-023168-cd7adns8	349	7	treatment	treatment	NN
cord-023168-cd7adns8	349	8	has	have	VBZ
cord-023168-cd7adns8	349	9	met	meet	VBN
cord-023168-cd7adns8	349	10	with	with	IN
cord-023168-cd7adns8	349	11	variable	variable	JJ
cord-023168-cd7adns8	349	12	success	success	NN
cord-023168-cd7adns8	349	13	rates	rate	NNS
cord-023168-cd7adns8	349	14	probably	probably	RB
cord-023168-cd7adns8	349	15	because	because	IN
cord-023168-cd7adns8	349	16	there	there	EX
cord-023168-cd7adns8	349	17	is	be	VBZ
cord-023168-cd7adns8	349	18	associated	associate	VBN
cord-023168-cd7adns8	349	19	anaemia	anaemia	NN
cord-023168-cd7adns8	349	20	related	relate	VBN
cord-023168-cd7adns8	349	21	to	to	IN
cord-023168-cd7adns8	349	22	inflammation	inflammation	NN
cord-023168-cd7adns8	349	23	.	.	.
cord-023168-cd7adns8	350	1	However	however	RB
cord-023168-cd7adns8	350	2	it	-PRON-	PRP
cord-023168-cd7adns8	350	3	is	be	VBZ
cord-023168-cd7adns8	350	4	still	still	RB
cord-023168-cd7adns8	350	5	generally	generally	RB
cord-023168-cd7adns8	350	6	recommended	recommend	VBN
cord-023168-cd7adns8	350	7	that	that	IN
cord-023168-cd7adns8	350	8	iron	iron	NN
cord-023168-cd7adns8	350	9	supplementation	supplementation	NN
cord-023168-cd7adns8	350	10	should	should	MD
cord-023168-cd7adns8	350	11	be	be	VB
cord-023168-cd7adns8	350	12	included	include	VBN
cord-023168-cd7adns8	350	13	with	with	IN
cord-023168-cd7adns8	350	14	anthelmintic	anthelmintic	JJ
cord-023168-cd7adns8	350	15	therapy	therapy	NN
cord-023168-cd7adns8	350	16	in	in	IN
cord-023168-cd7adns8	350	17	treatment	treatment	NN
cord-023168-cd7adns8	350	18	programmes	programme	NNS
cord-023168-cd7adns8	350	19	for	for	IN
cord-023168-cd7adns8	350	20	neglected	neglect	VBN
cord-023168-cd7adns8	350	21	tropical	tropical	JJ
cord-023168-cd7adns8	350	22	diseases	disease	NNS
cord-023168-cd7adns8	350	23	.	.	.
cord-023168-cd7adns8	351	1	[	[	-LRB-
cord-023168-cd7adns8	351	2	65	65	CD
cord-023168-cd7adns8	351	3	]	]	-RRB-
cord-023168-cd7adns8	351	4	[	[	-LRB-
cord-023168-cd7adns8	351	5	66	66	CD
cord-023168-cd7adns8	351	6	]	]	-RRB-
cord-023168-cd7adns8	351	7	[	[	-LRB-
cord-023168-cd7adns8	351	8	67	67	CD
cord-023168-cd7adns8	351	9	]	]	-RRB-
cord-023168-cd7adns8	351	10	INTRODUCTION	introduction	JJ
cord-023168-cd7adns8	351	11	Haemoglobin	Haemoglobin	NNP
cord-023168-cd7adns8	351	12	S	S	NNP
cord-023168-cd7adns8	351	13	(	(	-LRB-
cord-023168-cd7adns8	351	14	HbS	HbS	NNP
cord-023168-cd7adns8	351	15	)	)	-RRB-
cord-023168-cd7adns8	351	16	has	have	VBZ
cord-023168-cd7adns8	351	17	a	a	DT
cord-023168-cd7adns8	351	18	prevalence	prevalence	NN
cord-023168-cd7adns8	351	19	of	of	IN
cord-023168-cd7adns8	351	20	25	25	CD
cord-023168-cd7adns8	351	21	-	-	SYM
cord-023168-cd7adns8	351	22	30	30	CD
cord-023168-cd7adns8	351	23	%	%	NN
cord-023168-cd7adns8	351	24	in	in	IN
cord-023168-cd7adns8	351	25	many	many	JJ
cord-023168-cd7adns8	351	26	parts	part	NNS
cord-023168-cd7adns8	351	27	of	of	IN
cord-023168-cd7adns8	351	28	Africa	Africa	NNP
cord-023168-cd7adns8	351	29	and	and	CC
cord-023168-cd7adns8	351	30	also	also	RB
cord-023168-cd7adns8	351	31	some	some	DT
cord-023168-cd7adns8	351	32	areas	area	NNS
cord-023168-cd7adns8	351	33	in	in	IN
cord-023168-cd7adns8	351	34	the	the	DT
cord-023168-cd7adns8	351	35	Middle	Middle	NNP
cord-023168-cd7adns8	351	36	East	East	NNP
cord-023168-cd7adns8	352	1	(	(	-LRB-
cord-023168-cd7adns8	352	2	Figure	figure	NN
cord-023168-cd7adns8	352	3	 	 	_SP
cord-023168-cd7adns8	352	4	65	65	CD
cord-023168-cd7adns8	352	5	.6	.6	CD
cord-023168-cd7adns8	352	6	)	)	-RRB-
cord-023168-cd7adns8	352	7	.	.	.
cord-023168-cd7adns8	353	1	HbS	HbS	NNP
cord-023168-cd7adns8	353	2	tends	tend	VBZ
cord-023168-cd7adns8	353	3	to	to	TO
cord-023168-cd7adns8	353	4	be	be	VB
cord-023168-cd7adns8	353	5	common	common	JJ
cord-023168-cd7adns8	353	6	among	among	IN
cord-023168-cd7adns8	353	7	ethnic	ethnic	JJ
cord-023168-cd7adns8	353	8	groups	group	NNS
cord-023168-cd7adns8	353	9	that	that	WDT
cord-023168-cd7adns8	353	10	have	have	VBP
cord-023168-cd7adns8	353	11	traditionally	traditionally	RB
cord-023168-cd7adns8	353	12	had	have	VBN
cord-023168-cd7adns8	353	13	high	high	JJ
cord-023168-cd7adns8	353	14	exposure	exposure	NN
cord-023168-cd7adns8	353	15	to	to	IN
cord-023168-cd7adns8	353	16	Plasmodium	plasmodium	NN
cord-023168-cd7adns8	353	17	falciparum	falciparum	NN
cord-023168-cd7adns8	353	18	malaria	malaria	NN
cord-023168-cd7adns8	353	19	.	.	.
cord-023168-cd7adns8	354	1	In	in	IN
cord-023168-cd7adns8	354	2	sub	sub	JJ
cord-023168-cd7adns8	354	3	-	-	JJ
cord-023168-cd7adns8	354	4	Saharan	Saharan	NNP
cord-023168-cd7adns8	354	5	Africa	Africa	NNP
cord-023168-cd7adns8	354	6	approximately	approximately	RB
cord-023168-cd7adns8	354	7	230	230	CD
cord-023168-cd7adns8	354	8	000	000	CD
cord-023168-cd7adns8	354	9	infants	infant	NNS
cord-023168-cd7adns8	354	10	are	be	VBP
cord-023168-cd7adns8	354	11	born	bear	VBN
cord-023168-cd7adns8	354	12	with	with	IN
cord-023168-cd7adns8	354	13	sickle	sickle	NN
cord-023168-cd7adns8	354	14	cell	cell	NN
cord-023168-cd7adns8	354	15	disease	disease	NN
cord-023168-cd7adns8	354	16	each	each	DT
cord-023168-cd7adns8	354	17	year	year	NN
cord-023168-cd7adns8	354	18	,	,	,
cord-023168-cd7adns8	354	19	mostly	mostly	RB
cord-023168-cd7adns8	354	20	with	with	IN
cord-023168-cd7adns8	354	21	HbSS	HbSS	NNP
cord-023168-cd7adns8	354	22	.	.	.
cord-023168-cd7adns8	355	1	Sickle	sickle	NN
cord-023168-cd7adns8	355	2	cell	cell	NN
cord-023168-cd7adns8	355	3	disease	disease	NN
cord-023168-cd7adns8	355	4	(	(	-LRB-
cord-023168-cd7adns8	355	5	SCD	SCD	NNP
cord-023168-cd7adns8	355	6	)	)	-RRB-
cord-023168-cd7adns8	355	7	is	be	VBZ
cord-023168-cd7adns8	355	8	an	an	DT
cord-023168-cd7adns8	355	9	autosomal	autosomal	JJ
cord-023168-cd7adns8	355	10	recessive	recessive	JJ
cord-023168-cd7adns8	355	11	disorder	disorder	NN
cord-023168-cd7adns8	355	12	characterized	characterize	VBN
cord-023168-cd7adns8	355	13	by	by	IN
cord-023168-cd7adns8	355	14	production	production	NN
cord-023168-cd7adns8	355	15	of	of	IN
cord-023168-cd7adns8	355	16	an	an	DT
cord-023168-cd7adns8	355	17	abnormal	abnormal	JJ
cord-023168-cd7adns8	355	18	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	355	19	,	,	,
cord-023168-cd7adns8	355	20	sickle	sickle	NN
cord-023168-cd7adns8	355	21	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	355	22	.	.	.
cord-023168-cd7adns8	356	1	Sickle	sickle	NN
cord-023168-cd7adns8	356	2	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	356	3	(	(	-LRB-
cord-023168-cd7adns8	356	4	HbS	HbS	NNP
cord-023168-cd7adns8	356	5	)	)	-RRB-
cord-023168-cd7adns8	356	6	arises	arise	VBZ
cord-023168-cd7adns8	356	7	from	from	IN
cord-023168-cd7adns8	356	8	a	a	DT
cord-023168-cd7adns8	356	9	mutation	mutation	NN
cord-023168-cd7adns8	356	10	in	in	IN
cord-023168-cd7adns8	356	11	codon	codon	NN
cord-023168-cd7adns8	356	12	6	6	CD
cord-023168-cd7adns8	356	13	of	of	IN
cord-023168-cd7adns8	356	14	the	the	DT
cord-023168-cd7adns8	356	15	β	β	NN
cord-023168-cd7adns8	356	16	-	-	HYPH
cord-023168-cd7adns8	356	17	globin	globin	NN
cord-023168-cd7adns8	356	18	gene	gene	NN
cord-023168-cd7adns8	356	19	resulting	result	VBG
cord-023168-cd7adns8	356	20	in	in	IN
cord-023168-cd7adns8	356	21	replacement	replacement	NN
cord-023168-cd7adns8	356	22	of	of	IN
cord-023168-cd7adns8	356	23	the	the	DT
cord-023168-cd7adns8	356	24	normal	normal	JJ
cord-023168-cd7adns8	356	25	glutamic	glutamic	NN
cord-023168-cd7adns8	356	26	acid	acid	NN
cord-023168-cd7adns8	356	27	residue	residue	NN
cord-023168-cd7adns8	356	28	by	by	IN
cord-023168-cd7adns8	356	29	a	a	DT
cord-023168-cd7adns8	356	30	valine	valine	NN
cord-023168-cd7adns8	356	31	.	.	.
cord-023168-cd7adns8	357	1	68	68	CD
cord-023168-cd7adns8	358	1	SCD	SCD	NNP
cord-023168-cd7adns8	358	2	is	be	VBZ
cord-023168-cd7adns8	358	3	most	most	RBS
cord-023168-cd7adns8	358	4	commonly	commonly	RB
cord-023168-cd7adns8	358	5	caused	cause	VBN
cord-023168-cd7adns8	358	6	by	by	IN
cord-023168-cd7adns8	358	7	the	the	DT
cord-023168-cd7adns8	358	8	co	co	NN
cord-023168-cd7adns8	358	9	-	-	NN
cord-023168-cd7adns8	358	10	inheritance	inheritance	NN
cord-023168-cd7adns8	358	11	of	of	IN
cord-023168-cd7adns8	358	12	two	two	CD
cord-023168-cd7adns8	358	13	sickle	sickle	NN
cord-023168-cd7adns8	358	14	cell	cell	NN
cord-023168-cd7adns8	358	15	genes	gene	NNS
cord-023168-cd7adns8	358	16	(	(	-LRB-
cord-023168-cd7adns8	358	17	homozygous	homozygous	JJ
cord-023168-cd7adns8	358	18	Hb	Hb	NNP
cord-023168-cd7adns8	358	19	SS	SS	NNP
cord-023168-cd7adns8	358	20	disease	disease	NN
cord-023168-cd7adns8	358	21	)	)	-RRB-
cord-023168-cd7adns8	358	22	but	but	CC
cord-023168-cd7adns8	358	23	patients	patient	NNS
cord-023168-cd7adns8	358	24	who	who	WP
cord-023168-cd7adns8	358	25	are	be	VBP
cord-023168-cd7adns8	358	26	heterozygous	heterozygous	JJ
cord-023168-cd7adns8	358	27	for	for	IN
cord-023168-cd7adns8	358	28	HbS	HbS	NNP
cord-023168-cd7adns8	358	29	and	and	CC
cord-023168-cd7adns8	358	30	for	for	IN
cord-023168-cd7adns8	358	31	another	another	DT
cord-023168-cd7adns8	358	32	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	358	33	mutation	mutation	NN
cord-023168-cd7adns8	358	34	such	such	JJ
cord-023168-cd7adns8	358	35	as	as	IN
cord-023168-cd7adns8	358	36	HbC	hbc	NN
cord-023168-cd7adns8	358	37	(	(	-LRB-
cord-023168-cd7adns8	358	38	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	358	39	SC	SC	NNP
cord-023168-cd7adns8	358	40	disease	disease	NN
cord-023168-cd7adns8	358	41	)	)	-RRB-
cord-023168-cd7adns8	358	42	or	or	CC
cord-023168-cd7adns8	358	43	β	β	NN
cord-023168-cd7adns8	358	44	-	-	HYPH
cord-023168-cd7adns8	358	45	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	358	46	(	(	-LRB-
cord-023168-cd7adns8	359	1	Sβ	Sβ	NNP
cord-023168-cd7adns8	359	2	0	0	CD
cord-023168-cd7adns8	359	3	and	and	CC
cord-023168-cd7adns8	359	4	Sβ	Sβ	NNP
cord-023168-cd7adns8	359	5	+	+	NN
cord-023168-cd7adns8	359	6	)	)	-RRB-
cord-023168-cd7adns8	359	7	can	can	MD
cord-023168-cd7adns8	359	8	also	also	RB
cord-023168-cd7adns8	359	9	present	present	VB
cord-023168-cd7adns8	359	10	with	with	IN
cord-023168-cd7adns8	359	11	features	feature	NNS
cord-023168-cd7adns8	359	12	of	of	IN
cord-023168-cd7adns8	359	13	SCD	SCD	NNP
cord-023168-cd7adns8	359	14	.	.	.
cord-023168-cd7adns8	360	1	69	69	CD
cord-023168-cd7adns8	360	2	SS	SS	NNP
cord-023168-cd7adns8	360	3	disease	disease	NN
cord-023168-cd7adns8	360	4	and	and	CC
cord-023168-cd7adns8	360	5	Sβ	Sβ	NNP
cord-023168-cd7adns8	360	6	0	0	CD
cord-023168-cd7adns8	360	7	disease	disease	NN
cord-023168-cd7adns8	360	8	are	be	VBP
cord-023168-cd7adns8	360	9	more	more	RBR
cord-023168-cd7adns8	360	10	severe	severe	JJ
cord-023168-cd7adns8	360	11	than	than	IN
cord-023168-cd7adns8	360	12	SC	SC	NNP
cord-023168-cd7adns8	360	13	disease	disease	NN
cord-023168-cd7adns8	360	14	and	and	CC
cord-023168-cd7adns8	360	15	Sβ	Sβ	NNP
cord-023168-cd7adns8	360	16	+	+	CC
cord-023168-cd7adns8	360	17	disease	disease	NN
cord-023168-cd7adns8	360	18	(	(	-LRB-
cord-023168-cd7adns8	360	19	Box	Box	NNP
cord-023168-cd7adns8	360	20	65.6	65.6	CD
cord-023168-cd7adns8	360	21	)	)	-RRB-
cord-023168-cd7adns8	360	22	.	.	.
cord-023168-cd7adns8	361	1	70	70	CD
cord-023168-cd7adns8	361	2	SCD	SCD	NNP
cord-023168-cd7adns8	361	3	can	can	MD
cord-023168-cd7adns8	361	4	affect	affect	VB
cord-023168-cd7adns8	361	5	multiple	multiple	JJ
cord-023168-cd7adns8	361	6	organs	organ	NNS
cord-023168-cd7adns8	361	7	and	and	CC
cord-023168-cd7adns8	361	8	its	-PRON-	PRP$
cord-023168-cd7adns8	361	9	clinical	clinical	JJ
cord-023168-cd7adns8	361	10	course	course	NN
cord-023168-cd7adns8	361	11	is	be	VBZ
cord-023168-cd7adns8	361	12	punctuated	punctuate	VBN
cord-023168-cd7adns8	361	13	by	by	IN
cord-023168-cd7adns8	361	14	episodes	episode	NNS
cord-023168-cd7adns8	361	15	of	of	IN
cord-023168-cd7adns8	361	16	acute	acute	JJ
cord-023168-cd7adns8	361	17	illness	illness	NN
cord-023168-cd7adns8	361	18	on	on	IN
cord-023168-cd7adns8	361	19	a	a	DT
cord-023168-cd7adns8	361	20	background	background	NN
cord-023168-cd7adns8	361	21	of	of	IN
cord-023168-cd7adns8	361	22	progressive	progressive	JJ
cord-023168-cd7adns8	361	23	organ	organ	NN
cord-023168-cd7adns8	361	24	damage	damage	NN
cord-023168-cd7adns8	361	25	,	,	,
cord-023168-cd7adns8	361	26	especially	especially	RB
cord-023168-cd7adns8	361	27	of	of	IN
cord-023168-cd7adns8	361	28	the	the	DT
cord-023168-cd7adns8	361	29	central	central	JJ
cord-023168-cd7adns8	361	30	nervous	nervous	JJ
cord-023168-cd7adns8	361	31	system	system	NN
cord-023168-cd7adns8	361	32	and	and	CC
cord-023168-cd7adns8	361	33	the	the	DT
cord-023168-cd7adns8	361	34	lungs	lung	NNS
cord-023168-cd7adns8	361	35	.	.	.
cord-023168-cd7adns8	362	1	70	70	CD
cord-023168-cd7adns8	362	2	 	 	_SP
cord-023168-cd7adns8	363	1	The	the	DT
cord-023168-cd7adns8	363	2	first	first	JJ
cord-023168-cd7adns8	363	3	description	description	NN
cord-023168-cd7adns8	363	4	of	of	IN
cord-023168-cd7adns8	363	5	SCD	SCD	NNP
cord-023168-cd7adns8	363	6	was	be	VBD
cord-023168-cd7adns8	363	7	in	in	IN
cord-023168-cd7adns8	363	8	1910	1910	CD
cord-023168-cd7adns8	363	9	in	in	IN
cord-023168-cd7adns8	363	10	an	an	DT
cord-023168-cd7adns8	363	11	anaemic	anaemic	JJ
cord-023168-cd7adns8	363	12	Grenadian	grenadian	JJ
cord-023168-cd7adns8	363	13	dental	dental	JJ
cord-023168-cd7adns8	363	14	student	student	NN
cord-023168-cd7adns8	363	15	71	71	CD
cord-023168-cd7adns8	363	16	and	and	CC
cord-023168-cd7adns8	363	17	over	over	IN
cord-023168-cd7adns8	363	18	the	the	DT
cord-023168-cd7adns8	363	19	next	next	JJ
cord-023168-cd7adns8	363	20	30	30	CD
cord-023168-cd7adns8	363	21	years	year	NNS
cord-023168-cd7adns8	364	1	it	-PRON-	PRP
cord-023168-cd7adns8	364	2	was	be	VBD
cord-023168-cd7adns8	364	3	that	that	IN
cord-023168-cd7adns8	364	4	the	the	DT
cord-023168-cd7adns8	364	5	underlying	underlying	JJ
cord-023168-cd7adns8	364	6	cause	cause	NN
cord-023168-cd7adns8	364	7	of	of	IN
cord-023168-cd7adns8	364	8	folate	folate	JJ
cord-023168-cd7adns8	364	9	deficiency	deficiency	NN
cord-023168-cd7adns8	364	10	is	be	VBZ
cord-023168-cd7adns8	364	11	identified	identify	VBN
cord-023168-cd7adns8	364	12	and	and	CC
cord-023168-cd7adns8	364	13	treated	treat	VBN
cord-023168-cd7adns8	364	14	.	.	.
cord-023168-cd7adns8	365	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	365	2	A	a	NN
cord-023168-cd7adns8	365	3	is	be	VBZ
cord-023168-cd7adns8	365	4	important	important	JJ
cord-023168-cd7adns8	365	5	in	in	IN
cord-023168-cd7adns8	365	6	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	365	7	,	,	,
cord-023168-cd7adns8	365	8	iron	iron	NN
cord-023168-cd7adns8	365	9	metabolism	metabolism	NN
cord-023168-cd7adns8	365	10	(	(	-LRB-
cord-023168-cd7adns8	365	11	enhances	enhance	VBZ
cord-023168-cd7adns8	365	12	iron	iron	NN
cord-023168-cd7adns8	365	13	absorption	absorption	NN
cord-023168-cd7adns8	365	14	and	and	CC
cord-023168-cd7adns8	365	15	its	-PRON-	PRP$
cord-023168-cd7adns8	365	16	release	release	NN
cord-023168-cd7adns8	365	17	from	from	IN
cord-023168-cd7adns8	365	18	stores	store	NNS
cord-023168-cd7adns8	365	19	to	to	IN
cord-023168-cd7adns8	365	20	the	the	DT
cord-023168-cd7adns8	365	21	bone	bone	NN
cord-023168-cd7adns8	365	22	marrow	marrow	NN
cord-023168-cd7adns8	365	23	)	)	-RRB-
cord-023168-cd7adns8	365	24	and	and	CC
cord-023168-cd7adns8	365	25	for	for	IN
cord-023168-cd7adns8	365	26	decreasing	decrease	VBG
cord-023168-cd7adns8	365	27	the	the	DT
cord-023168-cd7adns8	365	28	risk	risk	NN
cord-023168-cd7adns8	365	29	of	of	IN
cord-023168-cd7adns8	365	30	infections	infection	NNS
cord-023168-cd7adns8	365	31	.	.	.
cord-023168-cd7adns8	366	1	45	45	CD
cord-023168-cd7adns8	367	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	367	2	A	a	DT
cord-023168-cd7adns8	367	3	deficiency	deficiency	NN
cord-023168-cd7adns8	367	4	is	be	VBZ
cord-023168-cd7adns8	367	5	a	a	DT
cord-023168-cd7adns8	367	6	major	major	JJ
cord-023168-cd7adns8	367	7	public	public	JJ
cord-023168-cd7adns8	367	8	health	health	NN
cord-023168-cd7adns8	367	9	problem	problem	NN
cord-023168-cd7adns8	367	10	in	in	IN
cord-023168-cd7adns8	367	11	lowincome	lowincome	NNP
cord-023168-cd7adns8	367	12	countries	country	NNS
cord-023168-cd7adns8	367	13	,	,	,
cord-023168-cd7adns8	367	14	with	with	IN
cord-023168-cd7adns8	367	15	an	an	DT
cord-023168-cd7adns8	367	16	estimated	estimate	VBN
cord-023168-cd7adns8	367	17	200	200	CD
cord-023168-cd7adns8	367	18	million	million	CD
cord-023168-cd7adns8	367	19	preschool	preschool	NN
cord-023168-cd7adns8	367	20	children	child	NNS
cord-023168-cd7adns8	367	21	affected	affect	VBN
cord-023168-cd7adns8	367	22	.	.	.
cord-023168-cd7adns8	368	1	47	47	CD
cord-023168-cd7adns8	368	2	Pregnant	pregnant	JJ
cord-023168-cd7adns8	368	3	women	woman	NNS
cord-023168-cd7adns8	368	4	and	and	CC
cord-023168-cd7adns8	368	5	women	woman	NNS
cord-023168-cd7adns8	368	6	of	of	IN
cord-023168-cd7adns8	368	7	childbearing	childbeare	VBG
cord-023168-cd7adns8	368	8	age	age	NN
cord-023168-cd7adns8	368	9	also	also	RB
cord-023168-cd7adns8	368	10	constitute	constitute	VBP
cord-023168-cd7adns8	368	11	high	high	JJ
cord-023168-cd7adns8	368	12	-	-	HYPH
cord-023168-cd7adns8	368	13	risk	risk	NN
cord-023168-cd7adns8	368	14	groups	group	NNS
cord-023168-cd7adns8	368	15	for	for	IN
cord-023168-cd7adns8	368	16	vitamin	vitamin	NN
cord-023168-cd7adns8	368	17	A	a	DT
cord-023168-cd7adns8	368	18	deficiency	deficiency	NN
cord-023168-cd7adns8	368	19	.	.	.
cord-023168-cd7adns8	369	1	46	46	CD
cord-023168-cd7adns8	369	2	Vitamin	vitamin	NN
cord-023168-cd7adns8	369	3	A	a	DT
cord-023168-cd7adns8	369	4	given	give	VBN
cord-023168-cd7adns8	369	5	to	to	IN
cord-023168-cd7adns8	369	6	Thai	thai	JJ
cord-023168-cd7adns8	369	7	school	school	NN
cord-023168-cd7adns8	369	8	children	child	NNS
cord-023168-cd7adns8	369	9	with	with	IN
cord-023168-cd7adns8	369	10	conjunctival	conjunctival	NN
cord-023168-cd7adns8	369	11	xerosis	xerosis	NN
cord-023168-cd7adns8	369	12	led	lead	VBD
cord-023168-cd7adns8	369	13	to	to	IN
cord-023168-cd7adns8	369	14	a	a	DT
cord-023168-cd7adns8	369	15	significant	significant	JJ
cord-023168-cd7adns8	369	16	increase	increase	NN
cord-023168-cd7adns8	369	17	in	in	IN
cord-023168-cd7adns8	369	18	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	369	19	level	level	NN
cord-023168-cd7adns8	369	20	47	47	CD
cord-023168-cd7adns8	369	21	and	and	CC
cord-023168-cd7adns8	369	22	in	in	IN
cord-023168-cd7adns8	369	23	anaemic	anaemic	JJ
cord-023168-cd7adns8	369	24	school	school	NN
cord-023168-cd7adns8	369	25	children	child	NNS
cord-023168-cd7adns8	369	26	in	in	IN
cord-023168-cd7adns8	369	27	Tanzania	Tanzania	NNP
cord-023168-cd7adns8	369	28	,	,	,
cord-023168-cd7adns8	369	29	vitamin	vitamin	NN
cord-023168-cd7adns8	369	30	A	a	DT
cord-023168-cd7adns8	369	31	supplementation	supplementation	NN
cord-023168-cd7adns8	369	32	produced	produce	VBD
cord-023168-cd7adns8	369	33	a	a	DT
cord-023168-cd7adns8	369	34	marked	marked	JJ
cord-023168-cd7adns8	369	35	increase	increase	NN
cord-023168-cd7adns8	369	36	in	in	IN
cord-023168-cd7adns8	369	37	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	369	38	which	which	WDT
cord-023168-cd7adns8	369	39	was	be	VBD
cord-023168-cd7adns8	369	40	enhanced	enhance	VBN
cord-023168-cd7adns8	369	41	by	by	IN
cord-023168-cd7adns8	369	42	co	co	NN
cord-023168-cd7adns8	369	43	-	-	NN
cord-023168-cd7adns8	369	44	administration	administration	NN
cord-023168-cd7adns8	369	45	of	of	IN
cord-023168-cd7adns8	369	46	iron	iron	NN
cord-023168-cd7adns8	369	47	.	.	.
cord-023168-cd7adns8	370	1	48	48	CD
cord-023168-cd7adns8	370	2	Vitamin	vitamin	NN
cord-023168-cd7adns8	370	3	A	a	NN
cord-023168-cd7adns8	370	4	can	can	MD
cord-023168-cd7adns8	370	5	also	also	RB
cord-023168-cd7adns8	370	6	improve	improve	VB
cord-023168-cd7adns8	370	7	anaemia	anaemia	NN
cord-023168-cd7adns8	370	8	in	in	IN
cord-023168-cd7adns8	370	9	pregnant	pregnant	JJ
cord-023168-cd7adns8	370	10	women	woman	NNS
cord-023168-cd7adns8	370	11	,	,	,
cord-023168-cd7adns8	370	12	depending	depend	VBG
cord-023168-cd7adns8	370	13	on	on	IN
cord-023168-cd7adns8	370	14	the	the	DT
cord-023168-cd7adns8	370	15	local	local	JJ
cord-023168-cd7adns8	370	16	prevalence	prevalence	NN
cord-023168-cd7adns8	370	17	of	of	IN
cord-023168-cd7adns8	370	18	deficiency	deficiency	NN
cord-023168-cd7adns8	370	19	[	[	-LRB-
cord-023168-cd7adns8	370	20	49	49	CD
cord-023168-cd7adns8	370	21	]	]	-RRB-
cord-023168-cd7adns8	370	22	[	[	-LRB-
cord-023168-cd7adns8	370	23	50	50	CD
cord-023168-cd7adns8	370	24	]	]	-RRB-
cord-023168-cd7adns8	370	25	[	[	-LRB-
cord-023168-cd7adns8	370	26	51	51	CD
cord-023168-cd7adns8	370	27	]	]	-RRB-
cord-023168-cd7adns8	370	28	[	[	-LRB-
cord-023168-cd7adns8	370	29	52	52	CD
cord-023168-cd7adns8	370	30	]	]	-RRB-
cord-023168-cd7adns8	370	31	though	though	IN
cord-023168-cd7adns8	370	32	the	the	DT
cord-023168-cd7adns8	370	33	response	response	NN
cord-023168-cd7adns8	370	34	may	may	MD
cord-023168-cd7adns8	370	35	be	be	VB
cord-023168-cd7adns8	370	36	suboptimal	suboptimal	JJ
cord-023168-cd7adns8	370	37	in	in	IN
cord-023168-cd7adns8	370	38	pregnant	pregnant	JJ
cord-023168-cd7adns8	370	39	women	woman	NNS
cord-023168-cd7adns8	370	40	infected	infect	VBN
cord-023168-cd7adns8	370	41	with	with	IN
cord-023168-cd7adns8	370	42	HIV	HIV	NNP
cord-023168-cd7adns8	370	43	.	.	.
cord-023168-cd7adns8	371	1	53	53	CD
cord-023168-cd7adns8	372	1	Copper	copper	NN
cord-023168-cd7adns8	372	2	is	be	VBZ
cord-023168-cd7adns8	372	3	a	a	DT
cord-023168-cd7adns8	372	4	trace	trace	NN
cord-023168-cd7adns8	372	5	element	element	NN
cord-023168-cd7adns8	372	6	necessary	necessary	JJ
cord-023168-cd7adns8	372	7	for	for	IN
cord-023168-cd7adns8	372	8	normal	normal	JJ
cord-023168-cd7adns8	372	9	haematopoiesis	haematopoiesis	NN
cord-023168-cd7adns8	372	10	and	and	CC
cord-023168-cd7adns8	372	11	myelopoiesis	myelopoiesis	NN
cord-023168-cd7adns8	372	12	.	.	.
cord-023168-cd7adns8	373	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	373	2	in	in	IN
cord-023168-cd7adns8	373	3	copper	copper	NN
cord-023168-cd7adns8	373	4	deficiency	deficiency	NN
cord-023168-cd7adns8	373	5	is	be	VBZ
cord-023168-cd7adns8	373	6	due	due	JJ
cord-023168-cd7adns8	373	7	to	to	IN
cord-023168-cd7adns8	373	8	decreased	decrease	VBN
cord-023168-cd7adns8	373	9	activity	activity	NN
cord-023168-cd7adns8	373	10	of	of	IN
cord-023168-cd7adns8	373	11	the	the	DT
cord-023168-cd7adns8	373	12	copper	copper	NN
cord-023168-cd7adns8	373	13	-	-	HYPH
cord-023168-cd7adns8	373	14	dependent	dependent	JJ
cord-023168-cd7adns8	373	15	enzymes	enzyme	NNS
cord-023168-cd7adns8	373	16	,	,	,
cord-023168-cd7adns8	373	17	hephaestin	hephaestin	NNP
cord-023168-cd7adns8	373	18	,	,	,
cord-023168-cd7adns8	373	19	ceruloplasmin	ceruloplasmin	NNP
cord-023168-cd7adns8	373	20	and	and	CC
cord-023168-cd7adns8	373	21	cytochrome	cytochrome	NN
cord-023168-cd7adns8	373	22	C	c	NN
cord-023168-cd7adns8	373	23	oxidase	oxidase	NN
cord-023168-cd7adns8	373	24	.	.	.
cord-023168-cd7adns8	374	1	These	these	DT
cord-023168-cd7adns8	374	2	are	be	VBP
cord-023168-cd7adns8	374	3	important	important	JJ
cord-023168-cd7adns8	374	4	in	in	IN
cord-023168-cd7adns8	374	5	ferrous	ferrous	JJ
cord-023168-cd7adns8	374	6	-	-	HYPH
cord-023168-cd7adns8	374	7	ferric	ferric	JJ
cord-023168-cd7adns8	374	8	iron	iron	NN
cord-023168-cd7adns8	374	9	conversions	conversion	NNS
cord-023168-cd7adns8	374	10	and	and	CC
cord-023168-cd7adns8	374	11	their	-PRON-	PRP$
cord-023168-cd7adns8	374	12	decrease	decrease	NN
cord-023168-cd7adns8	374	13	leads	lead	VBZ
cord-023168-cd7adns8	374	14	to	to	IN
cord-023168-cd7adns8	374	15	abnormalities	abnormality	NNS
cord-023168-cd7adns8	374	16	in	in	IN
cord-023168-cd7adns8	374	17	iron	iron	NN
cord-023168-cd7adns8	374	18	absorption	absorption	NN
cord-023168-cd7adns8	374	19	and	and	CC
cord-023168-cd7adns8	374	20	its	-PRON-	PRP$
cord-023168-cd7adns8	374	21	incorporation	incorporation	NN
cord-023168-cd7adns8	374	22	into	into	IN
cord-023168-cd7adns8	374	23	the	the	DT
cord-023168-cd7adns8	374	24	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	374	25	molecule	molecule	NN
cord-023168-cd7adns8	374	26	.	.	.
cord-023168-cd7adns8	375	1	Acquired	acquire	VBN
cord-023168-cd7adns8	375	2	copper	copper	NN
cord-023168-cd7adns8	375	3	deficiency	deficiency	NN
cord-023168-cd7adns8	375	4	occurs	occur	VBZ
cord-023168-cd7adns8	375	5	with	with	IN
cord-023168-cd7adns8	375	6	malnutrition	malnutrition	NN
cord-023168-cd7adns8	375	7	and	and	CC
cord-023168-cd7adns8	375	8	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	375	9	malabsorption	malabsorption	NN
cord-023168-cd7adns8	375	10	syndromes	syndrome	NNS
cord-023168-cd7adns8	375	11	.	.	.
cord-023168-cd7adns8	376	1	Coeliac	coeliac	JJ
cord-023168-cd7adns8	376	2	disease	disease	NN
cord-023168-cd7adns8	376	3	,	,	,
cord-023168-cd7adns8	376	4	cystic	cystic	JJ
cord-023168-cd7adns8	376	5	fibrosis	fibrosis	NN
cord-023168-cd7adns8	376	6	and	and	CC
cord-023168-cd7adns8	376	7	individuals	individual	NNS
cord-023168-cd7adns8	376	8	who	who	WP
cord-023168-cd7adns8	376	9	have	have	VBP
cord-023168-cd7adns8	376	10	had	have	VBN
cord-023168-cd7adns8	376	11	gastrectomy	gastrectomy	NN
cord-023168-cd7adns8	376	12	or	or	CC
cord-023168-cd7adns8	376	13	surgery	surgery	NN
cord-023168-cd7adns8	376	14	resulting	result	VBG
cord-023168-cd7adns8	376	15	in	in	IN
cord-023168-cd7adns8	376	16	'	'	``
cord-023168-cd7adns8	376	17	short	short	JJ
cord-023168-cd7adns8	376	18	bowel	bowel	NN
cord-023168-cd7adns8	376	19	'	'	''
cord-023168-cd7adns8	376	20	are	be	VBP
cord-023168-cd7adns8	376	21	also	also	RB
cord-023168-cd7adns8	376	22	at	at	IN
cord-023168-cd7adns8	376	23	risk	risk	NN
cord-023168-cd7adns8	376	24	.	.	.
cord-023168-cd7adns8	377	1	Copper	copper	NN
cord-023168-cd7adns8	377	2	deficiency	deficiency	NN
cord-023168-cd7adns8	377	3	has	have	VBZ
cord-023168-cd7adns8	377	4	also	also	RB
cord-023168-cd7adns8	377	5	been	be	VBN
cord-023168-cd7adns8	377	6	described	describe	VBN
cord-023168-cd7adns8	377	7	in	in	IN
cord-023168-cd7adns8	377	8	persons	person	NNS
cord-023168-cd7adns8	377	9	ingesting	ingest	VBG
cord-023168-cd7adns8	377	10	excessive	excessive	JJ
cord-023168-cd7adns8	377	11	amounts	amount	NNS
cord-023168-cd7adns8	377	12	of	of	IN
cord-023168-cd7adns8	377	13	zinc	zinc	NN
cord-023168-cd7adns8	377	14	-	-	HYPH
cord-023168-cd7adns8	377	15	containing	contain	VBG
cord-023168-cd7adns8	377	16	supplements	supplement	NNS
cord-023168-cd7adns8	377	17	and	and	CC
cord-023168-cd7adns8	377	18	those	those	DT
cord-023168-cd7adns8	377	19	who	who	WP
cord-023168-cd7adns8	377	20	have	have	VBP
cord-023168-cd7adns8	377	21	swallowed	swallow	VBN
cord-023168-cd7adns8	377	22	zinc	zinc	NN
cord-023168-cd7adns8	377	23	-	-	HYPH
cord-023168-cd7adns8	377	24	containing	contain	VBG
cord-023168-cd7adns8	377	25	coins	coin	NNS
cord-023168-cd7adns8	377	26	.	.	.
cord-023168-cd7adns8	378	1	54	54	CD
cord-023168-cd7adns8	378	2	,	,	,
cord-023168-cd7adns8	378	3	55	55	CD
cord-023168-cd7adns8	378	4	Anaemia	anaemia	NN
cord-023168-cd7adns8	378	5	related	relate	VBN
cord-023168-cd7adns8	378	6	to	to	IN
cord-023168-cd7adns8	378	7	copper	copper	NN
cord-023168-cd7adns8	378	8	deficiency	deficiency	NN
cord-023168-cd7adns8	378	9	is	be	VBZ
cord-023168-cd7adns8	378	10	normocytic	normocytic	JJ
cord-023168-cd7adns8	378	11	or	or	CC
cord-023168-cd7adns8	378	12	macrocytic	macrocytic	JJ
cord-023168-cd7adns8	378	13	and	and	CC
cord-023168-cd7adns8	378	14	can	can	MD
cord-023168-cd7adns8	378	15	be	be	VB
cord-023168-cd7adns8	378	16	associated	associate	VBN
cord-023168-cd7adns8	378	17	with	with	IN
cord-023168-cd7adns8	378	18	neutropenia	neutropenia	NN
cord-023168-cd7adns8	378	19	;	;	:
cord-023168-cd7adns8	378	20	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	378	21	is	be	VBZ
cord-023168-cd7adns8	378	22	rare	rare	JJ
cord-023168-cd7adns8	378	23	.	.	.
cord-023168-cd7adns8	379	1	Bone	bone	NN
cord-023168-cd7adns8	379	2	marrow	marrow	NN
cord-023168-cd7adns8	379	3	findings	finding	NNS
cord-023168-cd7adns8	379	4	are	be	VBP
cord-023168-cd7adns8	379	5	characteristic	characteristic	JJ
cord-023168-cd7adns8	379	6	with	with	IN
cord-023168-cd7adns8	379	7	cytoplasmic	cytoplasmic	JJ
cord-023168-cd7adns8	379	8	vacuolization	vacuolization	NN
cord-023168-cd7adns8	379	9	of	of	IN
cord-023168-cd7adns8	379	10	both	both	CC
cord-023168-cd7adns8	379	11	erythroid	erythroid	JJ
cord-023168-cd7adns8	379	12	and	and	CC
cord-023168-cd7adns8	379	13	myeloid	myeloid	JJ
cord-023168-cd7adns8	379	14	precursor	precursor	NN
cord-023168-cd7adns8	379	15	cells	cell	NNS
cord-023168-cd7adns8	379	16	with	with	IN
cord-023168-cd7adns8	379	17	ringed	ringed	JJ
cord-023168-cd7adns8	379	18	sideroblasts	sideroblast	NNS
cord-023168-cd7adns8	379	19	and	and	CC
cord-023168-cd7adns8	379	20	an	an	DT
cord-023168-cd7adns8	379	21	unusual	unusual	JJ
cord-023168-cd7adns8	379	22	finding	finding	NN
cord-023168-cd7adns8	379	23	of	of	IN
cord-023168-cd7adns8	379	24	iron	iron	NN
cord-023168-cd7adns8	379	25	granules	granule	NNS
cord-023168-cd7adns8	379	26	in	in	IN
cord-023168-cd7adns8	379	27	plasma	plasma	NN
cord-023168-cd7adns8	379	28	cells	cell	NNS
cord-023168-cd7adns8	379	29	.	.	.
cord-023168-cd7adns8	380	1	These	these	DT
cord-023168-cd7adns8	380	2	findings	finding	NNS
cord-023168-cd7adns8	380	3	may	may	MD
cord-023168-cd7adns8	380	4	be	be	VB
cord-023168-cd7adns8	380	5	misdiagnosed	misdiagnose	VBN
cord-023168-cd7adns8	380	6	as	as	IN
cord-023168-cd7adns8	380	7	myelodysplastic	myelodysplastic	JJ
cord-023168-cd7adns8	380	8	neoplasm	neoplasm	NN
cord-023168-cd7adns8	380	9	.	.	.
cord-023168-cd7adns8	381	1	Measurement	Measurement	NNP
cord-023168-cd7adns8	381	2	of	of	IN
cord-023168-cd7adns8	381	3	serum	serum	NN
cord-023168-cd7adns8	381	4	copper	copper	NN
cord-023168-cd7adns8	381	5	levels	level	NNS
cord-023168-cd7adns8	381	6	is	be	VBZ
cord-023168-cd7adns8	381	7	helpful	helpful	JJ
cord-023168-cd7adns8	381	8	in	in	IN
cord-023168-cd7adns8	381	9	confirming	confirm	VBG
cord-023168-cd7adns8	381	10	the	the	DT
cord-023168-cd7adns8	381	11	diagnosis	diagnosis	NN
cord-023168-cd7adns8	381	12	although	although	IN
cord-023168-cd7adns8	381	13	the	the	DT
cord-023168-cd7adns8	381	14	test	test	NN
cord-023168-cd7adns8	381	15	is	be	VBZ
cord-023168-cd7adns8	381	16	fairly	fairly	RB
cord-023168-cd7adns8	381	17	insensitive	insensitive	JJ
cord-023168-cd7adns8	381	18	.	.	.
cord-023168-cd7adns8	382	1	Since	since	IN
cord-023168-cd7adns8	382	2	almost	almost	RB
cord-023168-cd7adns8	382	3	complete	complete	JJ
cord-023168-cd7adns8	382	4	haematological	haematological	JJ
cord-023168-cd7adns8	382	5	recovery	recovery	NN
cord-023168-cd7adns8	382	6	can	can	MD
cord-023168-cd7adns8	382	7	occur	occur	VB
cord-023168-cd7adns8	382	8	with	with	IN
cord-023168-cd7adns8	382	9	copper	copper	NN
cord-023168-cd7adns8	382	10	replacement	replacement	NN
cord-023168-cd7adns8	382	11	,	,	,
cord-023168-cd7adns8	382	12	this	this	DT
cord-023168-cd7adns8	382	13	may	may	MD
cord-023168-cd7adns8	382	14	be	be	VB
cord-023168-cd7adns8	382	15	a	a	DT
cord-023168-cd7adns8	382	16	useful	useful	JJ
cord-023168-cd7adns8	382	17	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	382	18	test	test	NN
cord-023168-cd7adns8	382	19	.	.	.
cord-023168-cd7adns8	383	1	Oral	oral	JJ
cord-023168-cd7adns8	383	2	copper	copper	NN
cord-023168-cd7adns8	383	3	supplements	supplement	NNS
cord-023168-cd7adns8	383	4	can	can	MD
cord-023168-cd7adns8	383	5	be	be	VB
cord-023168-cd7adns8	383	6	started	start	VBN
cord-023168-cd7adns8	383	7	with	with	IN
cord-023168-cd7adns8	383	8	8	8	CD
cord-023168-cd7adns8	383	9	mg	mg	NNS
cord-023168-cd7adns8	383	10	of	of	IN
cord-023168-cd7adns8	383	11	elemental	elemental	JJ
cord-023168-cd7adns8	383	12	copper	copper	NN
cord-023168-cd7adns8	383	13	a	a	DT
cord-023168-cd7adns8	383	14	day	day	NN
cord-023168-cd7adns8	383	15	slowly	slowly	RB
cord-023168-cd7adns8	383	16	decreasing	decrease	VBG
cord-023168-cd7adns8	383	17	over	over	IN
cord-023168-cd7adns8	383	18	the	the	DT
cord-023168-cd7adns8	383	19	next	next	JJ
cord-023168-cd7adns8	383	20	few	few	JJ
cord-023168-cd7adns8	383	21	weeks	week	NNS
cord-023168-cd7adns8	383	22	to	to	IN
cord-023168-cd7adns8	383	23	2	2	CD
cord-023168-cd7adns8	383	24	mg	mg	NN
cord-023168-cd7adns8	383	25	until	until	IN
cord-023168-cd7adns8	383	26	a	a	DT
cord-023168-cd7adns8	383	27	good	good	JJ
cord-023168-cd7adns8	383	28	response	response	NN
cord-023168-cd7adns8	383	29	is	be	VBZ
cord-023168-cd7adns8	383	30	noted	note	VBN
cord-023168-cd7adns8	383	31	.	.	.
cord-023168-cd7adns8	384	1	Although	although	IN
cord-023168-cd7adns8	384	2	low	low	JJ
cord-023168-cd7adns8	384	3	zinc	zinc	NN
cord-023168-cd7adns8	384	4	levels	level	NNS
cord-023168-cd7adns8	384	5	do	do	VBP
cord-023168-cd7adns8	384	6	not	not	RB
cord-023168-cd7adns8	384	7	cause	cause	VB
cord-023168-cd7adns8	384	8	anaemia	anaemia	NN
cord-023168-cd7adns8	384	9	they	-PRON-	PRP
cord-023168-cd7adns8	384	10	have	have	VBP
cord-023168-cd7adns8	384	11	been	be	VBN
cord-023168-cd7adns8	384	12	linked	link	VBN
cord-023168-cd7adns8	384	13	to	to	IN
cord-023168-cd7adns8	384	14	growth	growth	NN
cord-023168-cd7adns8	384	15	retardation	retardation	NN
cord-023168-cd7adns8	384	16	,	,	,
cord-023168-cd7adns8	384	17	heightened	heightened	JJ
cord-023168-cd7adns8	384	18	susceptibility	susceptibility	NN
cord-023168-cd7adns8	384	19	to	to	IN
cord-023168-cd7adns8	384	20	infection	infection	NN
cord-023168-cd7adns8	384	21	and	and	CC
cord-023168-cd7adns8	384	22	male	male	JJ
cord-023168-cd7adns8	384	23	hypogonadism	hypogonadism	NN
cord-023168-cd7adns8	384	24	in	in	IN
cord-023168-cd7adns8	384	25	relation	relation	NN
cord-023168-cd7adns8	384	26	to	to	IN
cord-023168-cd7adns8	384	27	sickle	sickle	NN
cord-023168-cd7adns8	384	28	cell	cell	NN
cord-023168-cd7adns8	384	29	disease	disease	NN
cord-023168-cd7adns8	384	30	.	.	.
cord-023168-cd7adns8	385	1	56	56	CD
cord-023168-cd7adns8	385	2	Zinc	zinc	NN
cord-023168-cd7adns8	385	3	deficiency	deficiency	NN
cord-023168-cd7adns8	385	4	has	have	VBZ
cord-023168-cd7adns8	385	5	been	be	VBN
cord-023168-cd7adns8	385	6	described	describe	VBN
cord-023168-cd7adns8	385	7	in	in	IN
cord-023168-cd7adns8	385	8	nearly	nearly	RB
cord-023168-cd7adns8	385	9	half	half	NN
cord-023168-cd7adns8	385	10	of	of	IN
cord-023168-cd7adns8	385	11	children	child	NNS
cord-023168-cd7adns8	385	12	and	and	CC
cord-023168-cd7adns8	385	13	70	70	CD
cord-023168-cd7adns8	385	14	%	%	NN
cord-023168-cd7adns8	385	15	of	of	IN
cord-023168-cd7adns8	385	16	adults	adult	NNS
cord-023168-cd7adns8	385	17	with	with	IN
cord-023168-cd7adns8	385	18	sickle	sickle	NN
cord-023168-cd7adns8	385	19	cell	cell	NN
cord-023168-cd7adns8	385	20	disease	disease	NN
cord-023168-cd7adns8	385	21	possibly	possibly	RB
cord-023168-cd7adns8	385	22	due	due	JJ
cord-023168-cd7adns8	385	23	to	to	IN
cord-023168-cd7adns8	385	24	increased	increase	VBN
cord-023168-cd7adns8	385	25	loss	loss	NN
cord-023168-cd7adns8	385	26	of	of	IN
cord-023168-cd7adns8	385	27	zinc	zinc	NN
cord-023168-cd7adns8	385	28	in	in	IN
cord-023168-cd7adns8	385	29	the	the	DT
cord-023168-cd7adns8	385	30	urine	urine	NN
cord-023168-cd7adns8	385	31	and	and	CC
cord-023168-cd7adns8	385	32	high	high	JJ
cord-023168-cd7adns8	385	33	cell	cell	NN
cord-023168-cd7adns8	385	34	turnover	turnover	NN
cord-023168-cd7adns8	385	35	with	with	IN
cord-023168-cd7adns8	385	36	decreased	decrease	VBN
cord-023168-cd7adns8	385	37	dietary	dietary	JJ
cord-023168-cd7adns8	385	38	intake	intake	NN
cord-023168-cd7adns8	385	39	.	.	.
cord-023168-cd7adns8	386	1	57	57	CD
cord-023168-cd7adns8	387	1	In	in	IN
cord-023168-cd7adns8	387	2	contrast	contrast	NN
cord-023168-cd7adns8	387	3	zinc	zinc	NN
cord-023168-cd7adns8	387	4	excess	excess	NN
cord-023168-cd7adns8	387	5	can	can	MD
cord-023168-cd7adns8	387	6	cause	cause	VB
cord-023168-cd7adns8	387	7	anaemia	anaemia	NN
cord-023168-cd7adns8	387	8	through	through	IN
cord-023168-cd7adns8	387	9	interference	interference	NN
cord-023168-cd7adns8	387	10	with	with	IN
cord-023168-cd7adns8	387	11	copper	copper	NN
cord-023168-cd7adns8	387	12	absorption	absorption	NN
cord-023168-cd7adns8	387	13	by	by	IN
cord-023168-cd7adns8	387	14	sequestering	sequester	VBG
cord-023168-cd7adns8	387	15	it	-PRON-	PRP
cord-023168-cd7adns8	387	16	in	in	IN
cord-023168-cd7adns8	387	17	the	the	DT
cord-023168-cd7adns8	387	18	gut	gut	NN
cord-023168-cd7adns8	387	19	lumen	lumen	NN
cord-023168-cd7adns8	387	20	.	.	.
cord-023168-cd7adns8	388	1	For	for	IN
cord-023168-cd7adns8	388	2	this	this	DT
cord-023168-cd7adns8	388	3	reason	reason	NN
cord-023168-cd7adns8	388	4	,	,	,
cord-023168-cd7adns8	388	5	zinc	zinc	NN
cord-023168-cd7adns8	388	6	compounds	compound	NNS
cord-023168-cd7adns8	388	7	have	have	VBP
cord-023168-cd7adns8	388	8	been	be	VBN
cord-023168-cd7adns8	388	9	used	use	VBN
cord-023168-cd7adns8	388	10	to	to	TO
cord-023168-cd7adns8	388	11	treat	treat	VB
cord-023168-cd7adns8	388	12	Wilson	Wilson	NNP
cord-023168-cd7adns8	388	13	's	's	POS
cord-023168-cd7adns8	388	14	disease	disease	NN
cord-023168-cd7adns8	388	15	which	which	WDT
cord-023168-cd7adns8	388	16	is	be	VBZ
cord-023168-cd7adns8	388	17	characterized	characterize	VBN
cord-023168-cd7adns8	388	18	by	by	IN
cord-023168-cd7adns8	388	19	copper	copper	NN
cord-023168-cd7adns8	388	20	excess	excess	NN
cord-023168-cd7adns8	388	21	.	.	.
cord-023168-cd7adns8	389	1	However	however	RB
cord-023168-cd7adns8	389	2	repeated	repeat	VBN
cord-023168-cd7adns8	389	3	sickling	sickling	NN
cord-023168-cd7adns8	389	4	and	and	CC
cord-023168-cd7adns8	389	5	unsickling	unsickling	NN
cord-023168-cd7adns8	389	6	eventually	eventually	RB
cord-023168-cd7adns8	389	7	causes	cause	VBZ
cord-023168-cd7adns8	389	8	irreversible	irreversible	JJ
cord-023168-cd7adns8	389	9	changes	change	NNS
cord-023168-cd7adns8	389	10	,	,	,
cord-023168-cd7adns8	389	11	77	77	CD
cord-023168-cd7adns8	389	12	so	so	RB
cord-023168-cd7adns8	389	13	early	early	JJ
cord-023168-cd7adns8	389	14	management	management	NN
cord-023168-cd7adns8	389	15	to	to	TO
cord-023168-cd7adns8	389	16	avoid	avoid	VB
cord-023168-cd7adns8	389	17	repeated	repeat	VBN
cord-023168-cd7adns8	389	18	crises	crisis	NNS
cord-023168-cd7adns8	389	19	is	be	VBZ
cord-023168-cd7adns8	389	20	important	important	JJ
cord-023168-cd7adns8	389	21	to	to	TO
cord-023168-cd7adns8	389	22	prevent	prevent	VB
cord-023168-cd7adns8	389	23	disease	disease	NN
cord-023168-cd7adns8	389	24	progression	progression	NN
cord-023168-cd7adns8	389	25	.	.	.
cord-023168-cd7adns8	390	1	Polymerization	polymerization	NN
cord-023168-cd7adns8	390	2	,	,	,
cord-023168-cd7adns8	390	3	and	and	CC
cord-023168-cd7adns8	390	4	therefore	therefore	RB
cord-023168-cd7adns8	390	5	the	the	DT
cord-023168-cd7adns8	390	6	clinical	clinical	JJ
cord-023168-cd7adns8	390	7	features	feature	NNS
cord-023168-cd7adns8	390	8	of	of	IN
cord-023168-cd7adns8	390	9	SCD	SCD	NNP
cord-023168-cd7adns8	390	10	,	,	,
cord-023168-cd7adns8	390	11	are	be	VBP
cord-023168-cd7adns8	390	12	influenced	influence	VBN
cord-023168-cd7adns8	390	13	by	by	IN
cord-023168-cd7adns8	390	14	three	three	CD
cord-023168-cd7adns8	390	15	main	main	JJ
cord-023168-cd7adns8	390	16	factors	factor	NNS
cord-023168-cd7adns8	390	17	78	78	CD
cord-023168-cd7adns8	390	18	;	;	:
cord-023168-cd7adns8	390	19	hypoxia	hypoxia	NN
cord-023168-cd7adns8	390	20	,	,	,
cord-023168-cd7adns8	390	21	the	the	DT
cord-023168-cd7adns8	390	22	intracellular	intracellular	JJ
cord-023168-cd7adns8	390	23	HbS	hbs	JJ
cord-023168-cd7adns8	390	24	concentration	concentration	NN
cord-023168-cd7adns8	390	25	and	and	CC
cord-023168-cd7adns8	390	26	the	the	DT
cord-023168-cd7adns8	390	27	co	co	NN
cord-023168-cd7adns8	390	28	-	-	NN
cord-023168-cd7adns8	390	29	existence	existence	NN
cord-023168-cd7adns8	390	30	of	of	IN
cord-023168-cd7adns8	390	31	other	other	JJ
cord-023168-cd7adns8	390	32	genetic	genetic	JJ
cord-023168-cd7adns8	390	33	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	390	34	abnormalities	abnormality	NNS
cord-023168-cd7adns8	390	35	(	(	-LRB-
cord-023168-cd7adns8	390	36	e.g.	e.g.	RB
cord-023168-cd7adns8	390	37	α	α	NN
cord-023168-cd7adns8	390	38	-	-	HYPH
cord-023168-cd7adns8	390	39	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	390	40	or	or	CC
cord-023168-cd7adns8	390	41	hereditary	hereditary	JJ
cord-023168-cd7adns8	390	42	persistence	persistence	NN
cord-023168-cd7adns8	390	43	of	of	IN
cord-023168-cd7adns8	390	44	fetal	fetal	JJ
cord-023168-cd7adns8	390	45	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	390	46	-	-	HYPH
cord-023168-cd7adns8	390	47	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	390	48	F	F	NNP
cord-023168-cd7adns8	390	49	)	)	-RRB-
cord-023168-cd7adns8	390	50	.	.	.
cord-023168-cd7adns8	391	1	79	79	CD
cord-023168-cd7adns8	392	1	Sickled	sickled	JJ
cord-023168-cd7adns8	392	2	red	red	JJ
cord-023168-cd7adns8	392	3	cells	cell	NNS
cord-023168-cd7adns8	392	4	lead	lead	VBP
cord-023168-cd7adns8	392	5	to	to	IN
cord-023168-cd7adns8	392	6	vaso	vaso	NNP
cord-023168-cd7adns8	392	7	-	-	HYPH
cord-023168-cd7adns8	392	8	occlusion	occlusion	NNP
cord-023168-cd7adns8	392	9	and	and	CC
cord-023168-cd7adns8	392	10	haemolysis	haemolysis	NN
cord-023168-cd7adns8	392	11	due	due	IN
cord-023168-cd7adns8	392	12	to	to	IN
cord-023168-cd7adns8	392	13	the	the	DT
cord-023168-cd7adns8	392	14	entrapment	entrapment	NN
cord-023168-cd7adns8	392	15	of	of	IN
cord-023168-cd7adns8	392	16	sickled	sickled	JJ
cord-023168-cd7adns8	392	17	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	392	18	in	in	IN
cord-023168-cd7adns8	392	19	the	the	DT
cord-023168-cd7adns8	392	20	microvasculature	microvasculature	NN
cord-023168-cd7adns8	392	21	and	and	CC
cord-023168-cd7adns8	392	22	upregulation	upregulation	NN
cord-023168-cd7adns8	392	23	of	of	IN
cord-023168-cd7adns8	392	24	adhesion	adhesion	NN
cord-023168-cd7adns8	392	25	receptors	receptor	NNS
cord-023168-cd7adns8	392	26	.	.	.
cord-023168-cd7adns8	393	1	76	76	CD
cord-023168-cd7adns8	393	2	,	,	,
cord-023168-cd7adns8	393	3	80	80	CD
cord-023168-cd7adns8	393	4	,	,	,
cord-023168-cd7adns8	393	5	81	81	CD
cord-023168-cd7adns8	393	6	White	white	JJ
cord-023168-cd7adns8	393	7	blood	blood	NN
cord-023168-cd7adns8	393	8	cells	cell	NNS
cord-023168-cd7adns8	393	9	contribute	contribute	VBP
cord-023168-cd7adns8	393	10	to	to	IN
cord-023168-cd7adns8	393	11	this	this	DT
cord-023168-cd7adns8	393	12	process	process	NN
cord-023168-cd7adns8	393	13	by	by	IN
cord-023168-cd7adns8	393	14	providing	provide	VBG
cord-023168-cd7adns8	393	15	an	an	DT
cord-023168-cd7adns8	393	16	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	393	17	discovered	discover	VBN
cord-023168-cd7adns8	393	18	hypoxia	hypoxia	NN
cord-023168-cd7adns8	393	19	led	lead	VBN
cord-023168-cd7adns8	393	20	to	to	IN
cord-023168-cd7adns8	393	21	red	red	JJ
cord-023168-cd7adns8	393	22	cell	cell	NN
cord-023168-cd7adns8	393	23	sickling	sickle	VBG
cord-023168-cd7adns8	393	24	72	72	CD
cord-023168-cd7adns8	393	25	SCD	SCD	NNP
cord-023168-cd7adns8	393	26	arises	arise	VBZ
cord-023168-cd7adns8	393	27	from	from	IN
cord-023168-cd7adns8	393	28	the	the	DT
cord-023168-cd7adns8	393	29	tendency	tendency	NN
cord-023168-cd7adns8	393	30	of	of	IN
cord-023168-cd7adns8	393	31	HbS	hbs	NN
cord-023168-cd7adns8	393	32	to	to	TO
cord-023168-cd7adns8	393	33	polymerize	polymerize	VB
cord-023168-cd7adns8	393	34	in	in	IN
cord-023168-cd7adns8	393	35	hypoxic	hypoxic	JJ
cord-023168-cd7adns8	393	36	states	state	NNS
cord-023168-cd7adns8	393	37	.	.	.
cord-023168-cd7adns8	394	1	This	this	DT
cord-023168-cd7adns8	394	2	phenomenon	phenomenon	NN
cord-023168-cd7adns8	394	3	occurs	occur	VBZ
cord-023168-cd7adns8	394	4	where	where	WRB
cord-023168-cd7adns8	394	5	there	there	EX
cord-023168-cd7adns8	394	6	is	be	VBZ
cord-023168-cd7adns8	394	7	deoxygenation	deoxygenation	NN
cord-023168-cd7adns8	394	8	and	and	CC
cord-023168-cd7adns8	394	9	is	be	VBZ
cord-023168-cd7adns8	394	10	due	due	JJ
cord-023168-cd7adns8	394	11	to	to	IN
cord-023168-cd7adns8	394	12	the	the	DT
cord-023168-cd7adns8	394	13	binding	binding	NN
cord-023168-cd7adns8	394	14	between	between	IN
cord-023168-cd7adns8	394	15	β1	β1	NNP
cord-023168-cd7adns8	394	16	and	and	CC
cord-023168-cd7adns8	394	17	β2	β2	NN
cord-023168-cd7adns8	394	18	chains	chain	NNS
cord-023168-cd7adns8	394	19	of	of	IN
cord-023168-cd7adns8	394	20	two	two	CD
cord-023168-cd7adns8	394	21	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	394	22	molecules	molecule	NNS
cord-023168-cd7adns8	394	23	,	,	,
cord-023168-cd7adns8	394	24	a	a	DT
cord-023168-cd7adns8	394	25	property	property	NN
cord-023168-cd7adns8	394	26	unique	unique	JJ
cord-023168-cd7adns8	394	27	to	to	IN
cord-023168-cd7adns8	394	28	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	394	29	variants	variant	NNS
cord-023168-cd7adns8	394	30	that	that	WDT
cord-023168-cd7adns8	394	31	have	have	VBP
cord-023168-cd7adns8	394	32	the	the	DT
cord-023168-cd7adns8	394	33	Glu-6-Val	Glu-6-Val	NNP
cord-023168-cd7adns8	394	34	substitution	substitution	NN
cord-023168-cd7adns8	394	35	.	.	.
cord-023168-cd7adns8	395	1	74	74	CD
cord-023168-cd7adns8	396	1	The	the	DT
cord-023168-cd7adns8	396	2	polymerized	polymerize	VBN
cord-023168-cd7adns8	396	3	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	396	4	fills	fill	VBZ
cord-023168-cd7adns8	396	5	the	the	DT
cord-023168-cd7adns8	396	6	erythrocyte	erythrocyte	NN
cord-023168-cd7adns8	396	7	and	and	CC
cord-023168-cd7adns8	396	8	deforms	deform	VBZ
cord-023168-cd7adns8	396	9	its	-PRON-	PRP$
cord-023168-cd7adns8	396	10	architecture	architecture	NN
cord-023168-cd7adns8	396	11	and	and	CC
cord-023168-cd7adns8	396	12	flexibility	flexibility	NN
cord-023168-cd7adns8	396	13	to	to	TO
cord-023168-cd7adns8	396	14	form	form	VB
cord-023168-cd7adns8	396	15	a	a	DT
cord-023168-cd7adns8	396	16	sickle	sickle	NN
cord-023168-cd7adns8	396	17	shape	shape	NN
cord-023168-cd7adns8	396	18	.	.	.
cord-023168-cd7adns8	397	1	This	this	DT
cord-023168-cd7adns8	397	2	alteration	alteration	NN
cord-023168-cd7adns8	397	3	in	in	IN
cord-023168-cd7adns8	397	4	the	the	DT
cord-023168-cd7adns8	397	5	structure	structure	NN
cord-023168-cd7adns8	397	6	promotes	promote	VBZ
cord-023168-cd7adns8	397	7	cellular	cellular	JJ
cord-023168-cd7adns8	397	8	dehydration	dehydration	NN
cord-023168-cd7adns8	397	9	,	,	,
cord-023168-cd7adns8	397	10	70	70	CD
cord-023168-cd7adns8	397	11	,	,	,
cord-023168-cd7adns8	397	12	75	75	CD
cord-023168-cd7adns8	397	13	,	,	,
cord-023168-cd7adns8	397	14	76	76	CD
cord-023168-cd7adns8	398	1	Upon	upon	IN
cord-023168-cd7adns8	398	2	reoxygenation	reoxygenation	NN
cord-023168-cd7adns8	398	3	,	,	,
cord-023168-cd7adns8	398	4	the	the	DT
cord-023168-cd7adns8	398	5	polymers	polymer	NNS
cord-023168-cd7adns8	398	6	dissolve	dissolve	VBP
cord-023168-cd7adns8	398	7	thus	thus	RB
cord-023168-cd7adns8	398	8	reversing	reverse	VBG
cord-023168-cd7adns8	398	9	the	the	DT
cord-023168-cd7adns8	398	10	sickling	sickling	NN
cord-023168-cd7adns8	398	11	process	process	NN
cord-023168-cd7adns8	398	12	.	.	.
cord-023168-cd7adns8	399	1	90	90	CD
cord-023168-cd7adns8	399	2	Exposure	exposure	NN
cord-023168-cd7adns8	399	3	to	to	IN
cord-023168-cd7adns8	399	4	cold	cold	JJ
cord-023168-cd7adns8	399	5	,	,	,
cord-023168-cd7adns8	399	6	fever	fever	NN
cord-023168-cd7adns8	399	7	,	,	,
cord-023168-cd7adns8	399	8	menstruation	menstruation	NN
cord-023168-cd7adns8	399	9	,	,	,
cord-023168-cd7adns8	399	10	alcohol	alcohol	NN
cord-023168-cd7adns8	399	11	intake	intake	NN
cord-023168-cd7adns8	399	12	and	and	CC
cord-023168-cd7adns8	399	13	dehydration	dehydration	NN
cord-023168-cd7adns8	399	14	can	can	MD
cord-023168-cd7adns8	399	15	precipitate	precipitate	VB
cord-023168-cd7adns8	399	16	pain	pain	NN
cord-023168-cd7adns8	399	17	crises	crisis	NNS
cord-023168-cd7adns8	399	18	.	.	.
cord-023168-cd7adns8	400	1	Unlike	unlike	IN
cord-023168-cd7adns8	400	2	acute	acute	JJ
cord-023168-cd7adns8	400	3	pain	pain	NN
cord-023168-cd7adns8	400	4	crises	crisis	NNS
cord-023168-cd7adns8	400	5	,	,	,
cord-023168-cd7adns8	400	6	chronic	chronic	JJ
cord-023168-cd7adns8	400	7	pain	pain	NN
cord-023168-cd7adns8	400	8	in	in	IN
cord-023168-cd7adns8	400	9	SCD	SCD	NNP
cord-023168-cd7adns8	400	10	usually	usually	RB
cord-023168-cd7adns8	400	11	has	have	VBZ
cord-023168-cd7adns8	400	12	an	an	DT
cord-023168-cd7adns8	400	13	identifiable	identifiable	JJ
cord-023168-cd7adns8	400	14	basis	basis	NN
cord-023168-cd7adns8	400	15	such	such	JJ
cord-023168-cd7adns8	400	16	as	as	IN
cord-023168-cd7adns8	400	17	femoral	femoral	JJ
cord-023168-cd7adns8	400	18	head	head	NN
cord-023168-cd7adns8	400	19	necrosis	necrosis	NN
cord-023168-cd7adns8	400	20	,	,	,
cord-023168-cd7adns8	400	21	osteoarthritis	osteoarthritis	NN
cord-023168-cd7adns8	400	22	or	or	CC
cord-023168-cd7adns8	400	23	chronic	chronic	JJ
cord-023168-cd7adns8	400	24	skin	skin	NN
cord-023168-cd7adns8	400	25	ulcers	ulcer	NNS
cord-023168-cd7adns8	400	26	.	.	.
cord-023168-cd7adns8	401	1	Sickle	sickle	NN
cord-023168-cd7adns8	401	2	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	401	3	have	have	VBP
cord-023168-cd7adns8	401	4	an	an	DT
cord-023168-cd7adns8	401	5	average	average	JJ
cord-023168-cd7adns8	401	6	life	life	NN
cord-023168-cd7adns8	401	7	span	span	NN
cord-023168-cd7adns8	401	8	of	of	IN
cord-023168-cd7adns8	401	9	17	17	CD
cord-023168-cd7adns8	401	10	days	day	NNS
cord-023168-cd7adns8	401	11	and	and	CC
cord-023168-cd7adns8	401	12	anaemia	anaemia	NN
cord-023168-cd7adns8	401	13	can	can	MD
cord-023168-cd7adns8	401	14	be	be	VB
cord-023168-cd7adns8	401	15	due	due	JJ
cord-023168-cd7adns8	401	16	to	to	IN
cord-023168-cd7adns8	401	17	several	several	JJ
cord-023168-cd7adns8	401	18	causes	cause	NNS
cord-023168-cd7adns8	401	19	(	(	-LRB-
cord-023168-cd7adns8	401	20	Box	Box	NNP
cord-023168-cd7adns8	401	21	65.8	65.8	CD
cord-023168-cd7adns8	401	22	)	)	-RRB-
cord-023168-cd7adns8	401	23	.	.	.
cord-023168-cd7adns8	402	1	Red	red	JJ
cord-023168-cd7adns8	402	2	cell	cell	NN
cord-023168-cd7adns8	402	3	haemolysis	haemolysis	NN
cord-023168-cd7adns8	402	4	causes	cause	VBZ
cord-023168-cd7adns8	402	5	anaemia	anaemia	NN
cord-023168-cd7adns8	402	6	and	and	CC
cord-023168-cd7adns8	402	7	gall	gall	NN
cord-023168-cd7adns8	402	8	stones	stone	NNS
cord-023168-cd7adns8	402	9	and	and	CC
cord-023168-cd7adns8	402	10	can	can	MD
cord-023168-cd7adns8	402	11	cause	cause	VB
cord-023168-cd7adns8	402	12	fatigue	fatigue	NN
cord-023168-cd7adns8	402	13	out	out	IN
cord-023168-cd7adns8	402	14	of	of	IN
cord-023168-cd7adns8	402	15	proportion	proportion	NN
cord-023168-cd7adns8	402	16	to	to	IN
cord-023168-cd7adns8	402	17	the	the	DT
cord-023168-cd7adns8	402	18	anaemia	anaemia	NN
cord-023168-cd7adns8	402	19	.	.	.
cord-023168-cd7adns8	403	1	91	91	CD
cord-023168-cd7adns8	403	2	,	,	,
cord-023168-cd7adns8	403	3	92	92	CD
cord-023168-cd7adns8	404	1	There	there	EX
cord-023168-cd7adns8	404	2	are	be	VBP
cord-023168-cd7adns8	404	3	suggestions	suggestion	NNS
cord-023168-cd7adns8	404	4	that	that	IN
cord-023168-cd7adns8	404	5	patients	patient	NNS
cord-023168-cd7adns8	404	6	with	with	IN
cord-023168-cd7adns8	404	7	low	low	JJ
cord-023168-cd7adns8	404	8	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	404	9	concentrations	concentration	NNS
cord-023168-cd7adns8	404	10	and	and	CC
cord-023168-cd7adns8	404	11	high	high	JJ
cord-023168-cd7adns8	404	12	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	404	13	rates	rate	NNS
cord-023168-cd7adns8	404	14	are	be	VBP
cord-023168-cd7adns8	404	15	more	more	RBR
cord-023168-cd7adns8	404	16	likely	likely	JJ
cord-023168-cd7adns8	404	17	to	to	TO
cord-023168-cd7adns8	404	18	develop	develop	VB
cord-023168-cd7adns8	404	19	vascular	vascular	JJ
cord-023168-cd7adns8	404	20	problems	problem	NNS
cord-023168-cd7adns8	404	21	compared	compare	VBN
cord-023168-cd7adns8	404	22	with	with	IN
cord-023168-cd7adns8	404	23	those	those	DT
cord-023168-cd7adns8	404	24	with	with	IN
cord-023168-cd7adns8	404	25	higher	high	JJR
cord-023168-cd7adns8	404	26	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	404	27	concentrations	concentration	NNS
cord-023168-cd7adns8	404	28	.	.	.
cord-023168-cd7adns8	405	1	Splenic	splenic	JJ
cord-023168-cd7adns8	405	2	sequestration	sequestration	NN
cord-023168-cd7adns8	405	3	with	with	IN
cord-023168-cd7adns8	405	4	a	a	DT
cord-023168-cd7adns8	405	5	sudden	sudden	JJ
cord-023168-cd7adns8	405	6	rapid	rapid	JJ
cord-023168-cd7adns8	405	7	drop	drop	NN
cord-023168-cd7adns8	405	8	in	in	IN
cord-023168-cd7adns8	405	9	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	405	10	occurs	occur	VBZ
cord-023168-cd7adns8	405	11	in	in	IN
cord-023168-cd7adns8	405	12	those	those	DT
cord-023168-cd7adns8	405	13	who	who	WP
cord-023168-cd7adns8	405	14	have	have	VBP
cord-023168-cd7adns8	405	15	not	not	RB
cord-023168-cd7adns8	405	16	yet	yet	RB
cord-023168-cd7adns8	405	17	developed	develop	VBN
cord-023168-cd7adns8	405	18	autosplenectomy	autosplenectomy	NN
cord-023168-cd7adns8	405	19	so	so	IN
cord-023168-cd7adns8	405	20	it	-PRON-	PRP
cord-023168-cd7adns8	405	21	can	can	MD
cord-023168-cd7adns8	405	22	occur	occur	VB
cord-023168-cd7adns8	405	23	in	in	IN
cord-023168-cd7adns8	405	24	young	young	JJ
cord-023168-cd7adns8	405	25	children	child	NNS
cord-023168-cd7adns8	405	26	with	with	IN
cord-023168-cd7adns8	405	27	HbSS	HbSS	NNP
cord-023168-cd7adns8	405	28	and	and	CC
cord-023168-cd7adns8	405	29	adults	adult	NNS
cord-023168-cd7adns8	405	30	with	with	IN
cord-023168-cd7adns8	405	31	HbSC	HbSC	NNP
cord-023168-cd7adns8	405	32	disease	disease	NN
cord-023168-cd7adns8	405	33	or	or	CC
cord-023168-cd7adns8	405	34	sickle	sickle	NN
cord-023168-cd7adns8	405	35	cell	cell	NN
cord-023168-cd7adns8	405	36	-	-	:
cord-023168-cd7adns8	405	37	β	β	NN
cord-023168-cd7adns8	405	38	+	+	CC
cord-023168-cd7adns8	405	39	-thalassaemia	-thalassaemia	CD
cord-023168-cd7adns8	405	40	.	.	.
cord-023168-cd7adns8	406	1	Treatment	treatment	NN
cord-023168-cd7adns8	406	2	may	may	MD
cord-023168-cd7adns8	406	3	require	require	VB
cord-023168-cd7adns8	406	4	blood	blood	NN
cord-023168-cd7adns8	406	5	transfusion	transfusion	NN
cord-023168-cd7adns8	406	6	and	and	CC
cord-023168-cd7adns8	406	7	in	in	IN
cord-023168-cd7adns8	406	8	rare	rare	JJ
cord-023168-cd7adns8	406	9	cases	case	NNS
cord-023168-cd7adns8	406	10	,	,	,
cord-023168-cd7adns8	406	11	sequestration	sequestration	NN
cord-023168-cd7adns8	406	12	can	can	MD
cord-023168-cd7adns8	406	13	be	be	VB
cord-023168-cd7adns8	406	14	fatal	fatal	JJ
cord-023168-cd7adns8	406	15	.	.	.
cord-023168-cd7adns8	407	1	Splenectomy	Splenectomy	NNP
cord-023168-cd7adns8	407	2	may	may	MD
cord-023168-cd7adns8	407	3	be	be	VB
cord-023168-cd7adns8	407	4	needed	need	VBN
cord-023168-cd7adns8	407	5	for	for	IN
cord-023168-cd7adns8	407	6	recurrent	recurrent	JJ
cord-023168-cd7adns8	407	7	severe	severe	JJ
cord-023168-cd7adns8	407	8	sequestration	sequestration	NN
cord-023168-cd7adns8	407	9	.	.	.
cord-023168-cd7adns8	408	1	Parents	parent	NNS
cord-023168-cd7adns8	408	2	can	can	MD
cord-023168-cd7adns8	408	3	be	be	VB
cord-023168-cd7adns8	408	4	taught	teach	VBN
cord-023168-cd7adns8	408	5	to	to	TO
cord-023168-cd7adns8	408	6	feel	feel	VB
cord-023168-cd7adns8	408	7	their	-PRON-	PRP$
cord-023168-cd7adns8	408	8	infant	infant	NN
cord-023168-cd7adns8	408	9	's	's	POS
cord-023168-cd7adns8	408	10	abdomen	abdomen	NN
cord-023168-cd7adns8	408	11	for	for	IN
cord-023168-cd7adns8	408	12	an	an	DT
cord-023168-cd7adns8	408	13	enlarging	enlarge	VBG
cord-023168-cd7adns8	408	14	spleen	spleen	NN
cord-023168-cd7adns8	408	15	and	and	CC
cord-023168-cd7adns8	408	16	report	report	NN
cord-023168-cd7adns8	408	17	to	to	IN
cord-023168-cd7adns8	408	18	hospital	hospital	NN
cord-023168-cd7adns8	408	19	if	if	IN
cord-023168-cd7adns8	408	20	there	there	EX
cord-023168-cd7adns8	408	21	is	be	VBZ
cord-023168-cd7adns8	408	22	a	a	DT
cord-023168-cd7adns8	408	23	sudden	sudden	JJ
cord-023168-cd7adns8	408	24	increase	increase	NN
cord-023168-cd7adns8	408	25	in	in	IN
cord-023168-cd7adns8	408	26	spleen	spleen	NN
cord-023168-cd7adns8	408	27	size	size	NN
cord-023168-cd7adns8	408	28	.	.	.
cord-023168-cd7adns8	409	1	Red	red	JJ
cord-023168-cd7adns8	409	2	cell	cell	NN
cord-023168-cd7adns8	409	3	aplasia	aplasia	NNP
cord-023168-cd7adns8	409	4	can	can	MD
cord-023168-cd7adns8	409	5	develop	develop	VB
cord-023168-cd7adns8	409	6	due	due	IN
cord-023168-cd7adns8	409	7	to	to	IN
cord-023168-cd7adns8	409	8	secondary	secondary	JJ
cord-023168-cd7adns8	409	9	parvovirus	parvovirus	NN
cord-023168-cd7adns8	409	10	infection	infection	NN
cord-023168-cd7adns8	409	11	which	which	WDT
cord-023168-cd7adns8	409	12	has	have	VBZ
cord-023168-cd7adns8	409	13	a	a	DT
cord-023168-cd7adns8	409	14	predilection	predilection	NN
cord-023168-cd7adns8	409	15	for	for	IN
cord-023168-cd7adns8	409	16	erythroid	erythroid	NN
cord-023168-cd7adns8	409	17	progenitors	progenitor	NNS
cord-023168-cd7adns8	409	18	.	.	.
cord-023168-cd7adns8	410	1	Alloimmunization	Alloimmunization	NNP
cord-023168-cd7adns8	410	2	is	be	VBZ
cord-023168-cd7adns8	410	3	common	common	JJ
cord-023168-cd7adns8	410	4	in	in	IN
cord-023168-cd7adns8	410	5	SCD	SCD	NNP
cord-023168-cd7adns8	410	6	patients	patient	NNS
cord-023168-cd7adns8	410	7	who	who	WP
cord-023168-cd7adns8	410	8	have	have	VBP
cord-023168-cd7adns8	410	9	had	have	VBN
cord-023168-cd7adns8	410	10	frequent	frequent	JJ
cord-023168-cd7adns8	410	11	transfusions	transfusion	NNS
cord-023168-cd7adns8	410	12	so	so	RB
cord-023168-cd7adns8	410	13	,	,	,
cord-023168-cd7adns8	410	14	if	if	IN
cord-023168-cd7adns8	410	15	possible	possible	JJ
cord-023168-cd7adns8	410	16	,	,	,
cord-023168-cd7adns8	410	17	extended	extended	JJ
cord-023168-cd7adns8	410	18	red	red	JJ
cord-023168-cd7adns8	410	19	cell	cell	NN
cord-023168-cd7adns8	410	20	phenotyping	phenotyping	NN
cord-023168-cd7adns8	410	21	should	should	MD
cord-023168-cd7adns8	410	22	be	be	VB
cord-023168-cd7adns8	410	23	undertaken	undertake	VBN
cord-023168-cd7adns8	410	24	.	.	.
cord-023168-cd7adns8	411	1	Hyperhaemolytic	Hyperhaemolytic	NNP
cord-023168-cd7adns8	411	2	crisis	crisis	NN
cord-023168-cd7adns8	411	3	is	be	VBZ
cord-023168-cd7adns8	411	4	suspected	suspect	VBN
cord-023168-cd7adns8	411	5	when	when	WRB
cord-023168-cd7adns8	411	6	there	there	EX
cord-023168-cd7adns8	411	7	is	be	VBZ
cord-023168-cd7adns8	411	8	sudden	sudden	JJ
cord-023168-cd7adns8	411	9	exacerbation	exacerbation	NN
cord-023168-cd7adns8	411	10	of	of	IN
cord-023168-cd7adns8	411	11	anaemia	anaemia	NN
cord-023168-cd7adns8	411	12	with	with	IN
cord-023168-cd7adns8	411	13	increased	increase	VBN
cord-023168-cd7adns8	411	14	reticulocytosis	reticulocytosis	NN
cord-023168-cd7adns8	411	15	and	and	CC
cord-023168-cd7adns8	411	16	bilirubin	bilirubin	JJ
cord-023168-cd7adns8	411	17	level	level	NN
cord-023168-cd7adns8	411	18	.	.	.
cord-023168-cd7adns8	412	1	Infectious	infectious	JJ
cord-023168-cd7adns8	412	2	complications	complication	NNS
cord-023168-cd7adns8	412	3	of	of	IN
cord-023168-cd7adns8	412	4	SCD	SCD	NNP
cord-023168-cd7adns8	412	5	are	be	VBP
cord-023168-cd7adns8	412	6	a	a	DT
cord-023168-cd7adns8	412	7	major	major	JJ
cord-023168-cd7adns8	412	8	cause	cause	NN
cord-023168-cd7adns8	412	9	of	of	IN
cord-023168-cd7adns8	412	10	morbidity	morbidity	NN
cord-023168-cd7adns8	412	11	and	and	CC
cord-023168-cd7adns8	412	12	mortality	mortality	NN
cord-023168-cd7adns8	412	13	,	,	,
cord-023168-cd7adns8	412	14	even	even	RB
cord-023168-cd7adns8	412	15	with	with	IN
cord-023168-cd7adns8	412	16	adequate	adequate	JJ
cord-023168-cd7adns8	412	17	vaccination	vaccination	NN
cord-023168-cd7adns8	412	18	and	and	CC
cord-023168-cd7adns8	412	19	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	412	20	antibiotic	antibiotic	JJ
cord-023168-cd7adns8	412	21	regimens	regimen	NNS
cord-023168-cd7adns8	412	22	.	.	.
cord-023168-cd7adns8	413	1	This	this	DT
cord-023168-cd7adns8	413	2	propensity	propensity	NN
cord-023168-cd7adns8	413	3	to	to	IN
cord-023168-cd7adns8	413	4	infection	infection	NN
cord-023168-cd7adns8	413	5	is	be	VBZ
cord-023168-cd7adns8	413	6	related	relate	VBN
cord-023168-cd7adns8	413	7	to	to	IN
cord-023168-cd7adns8	413	8	impaired	impaired	JJ
cord-023168-cd7adns8	413	9	splenic	splenic	JJ
cord-023168-cd7adns8	413	10	function	function	NN
cord-023168-cd7adns8	413	11	although	although	IN
cord-023168-cd7adns8	413	12	tissue	tissue	NN
cord-023168-cd7adns8	413	13	ischaemia	ischaemia	NN
cord-023168-cd7adns8	413	14	,	,	,
cord-023168-cd7adns8	413	15	especially	especially	RB
cord-023168-cd7adns8	413	16	in	in	IN
cord-023168-cd7adns8	413	17	the	the	DT
cord-023168-cd7adns8	413	18	lungs	lung	NNS
cord-023168-cd7adns8	413	19	and	and	CC
cord-023168-cd7adns8	413	20	renal	renal	JJ
cord-023168-cd7adns8	413	21	system	system	NN
cord-023168-cd7adns8	413	22	,	,	,
cord-023168-cd7adns8	413	23	can	can	MD
cord-023168-cd7adns8	413	24	contribute	contribute	VB
cord-023168-cd7adns8	413	25	.	.	.
cord-023168-cd7adns8	414	1	Hyposplenism	Hyposplenism	NNP
cord-023168-cd7adns8	414	2	is	be	VBZ
cord-023168-cd7adns8	414	3	demonstrable	demonstrable	JJ
cord-023168-cd7adns8	414	4	in	in	IN
cord-023168-cd7adns8	414	5	the	the	DT
cord-023168-cd7adns8	414	6	peripheral	peripheral	JJ
cord-023168-cd7adns8	414	7	blood	blood	NN
cord-023168-cd7adns8	414	8	film	film	NN
cord-023168-cd7adns8	414	9	by	by	IN
cord-023168-cd7adns8	414	10	the	the	DT
cord-023168-cd7adns8	414	11	presence	presence	NN
cord-023168-cd7adns8	414	12	of	of	IN
cord-023168-cd7adns8	414	13	Howell	Howell	NNP
cord-023168-cd7adns8	414	14	-	-	HYPH
cord-023168-cd7adns8	414	15	Jolly	Jolly	NNP
cord-023168-cd7adns8	414	16	bodies	body	NNS
cord-023168-cd7adns8	414	17	.	.	.
cord-023168-cd7adns8	415	1	Most	Most	JJS
cord-023168-cd7adns8	415	2	children	child	NNS
cord-023168-cd7adns8	415	3	with	with	IN
cord-023168-cd7adns8	415	4	SCD	SCD	NNP
cord-023168-cd7adns8	415	5	have	have	VBP
cord-023168-cd7adns8	415	6	undergone	undergo	VBN
cord-023168-cd7adns8	415	7	autosplenectomy	autosplenectomy	NN
cord-023168-cd7adns8	415	8	by	by	IN
cord-023168-cd7adns8	415	9	the	the	DT
cord-023168-cd7adns8	415	10	age	age	NN
cord-023168-cd7adns8	415	11	of	of	IN
cord-023168-cd7adns8	415	12	5	5	CD
cord-023168-cd7adns8	415	13	years	year	NNS
cord-023168-cd7adns8	415	14	and	and	CC
cord-023168-cd7adns8	415	15	therefore	therefore	RB
cord-023168-cd7adns8	415	16	have	have	VBP
cord-023168-cd7adns8	415	17	increased	increase	VBN
cord-023168-cd7adns8	415	18	risk	risk	NN
cord-023168-cd7adns8	415	19	of	of	IN
cord-023168-cd7adns8	415	20	infection	infection	NN
cord-023168-cd7adns8	415	21	from	from	IN
cord-023168-cd7adns8	415	22	encapsulated	encapsulate	VBN
cord-023168-cd7adns8	415	23	microorganisms	microorganism	NNS
cord-023168-cd7adns8	415	24	.	.	.
cord-023168-cd7adns8	416	1	93	93	CD
cord-023168-cd7adns8	417	1	Typical	typical	JJ
cord-023168-cd7adns8	417	2	infectious	infectious	JJ
cord-023168-cd7adns8	417	3	complications	complication	NNS
cord-023168-cd7adns8	417	4	include	include	VBP
cord-023168-cd7adns8	417	5	pneumococcal	pneumococcal	JJ
cord-023168-cd7adns8	417	6	sepsis	sepsis	NN
cord-023168-cd7adns8	417	7	,	,	,
cord-023168-cd7adns8	417	8	Neisseria	Neisseria	NNP
cord-023168-cd7adns8	417	9	meningitis	meningitis	NN
cord-023168-cd7adns8	417	10	,	,	,
cord-023168-cd7adns8	417	11	osteomyelitis	osteomyelitis	NN
cord-023168-cd7adns8	417	12	caused	cause	VBN
cord-023168-cd7adns8	417	13	by	by	IN
cord-023168-cd7adns8	417	14	Salmonella	Salmonella	NNP
cord-023168-cd7adns8	417	15	species	specie	NNS
cord-023168-cd7adns8	417	16	,	,	,
cord-023168-cd7adns8	417	17	urinary	urinary	JJ
cord-023168-cd7adns8	417	18	tract	tract	JJ
cord-023168-cd7adns8	417	19	infections	infection	NNS
cord-023168-cd7adns8	417	20	and	and	CC
cord-023168-cd7adns8	417	21	pyelonephritis	pyelonephritis	NN
cord-023168-cd7adns8	417	22	due	due	IN
cord-023168-cd7adns8	417	23	to	to	IN
cord-023168-cd7adns8	417	24	Escherichia	escherichia	NN
cord-023168-cd7adns8	417	25	coli	coli	NNS
cord-023168-cd7adns8	417	26	.	.	.
cord-023168-cd7adns8	418	1	Anatomical	anatomical	JJ
cord-023168-cd7adns8	418	2	abnormalities	abnormality	NNS
cord-023168-cd7adns8	418	3	such	such	JJ
cord-023168-cd7adns8	418	4	as	as	IN
cord-023168-cd7adns8	418	5	renal	renal	JJ
cord-023168-cd7adns8	418	6	papillary	papillary	JJ
cord-023168-cd7adns8	418	7	necrosis	necrosis	NN
cord-023168-cd7adns8	418	8	can	can	MD
cord-023168-cd7adns8	418	9	predispose	predispose	VB
cord-023168-cd7adns8	418	10	to	to	IN
cord-023168-cd7adns8	418	11	urinary	urinary	JJ
cord-023168-cd7adns8	418	12	complications	complication	NNS
cord-023168-cd7adns8	418	13	which	which	WDT
cord-023168-cd7adns8	418	14	may	may	MD
cord-023168-cd7adns8	418	15	require	require	VB
cord-023168-cd7adns8	418	16	long	long	JJ
cord-023168-cd7adns8	418	17	-	-	HYPH
cord-023168-cd7adns8	418	18	term	term	NN
cord-023168-cd7adns8	418	19	antibiotics	antibiotic	NNS
cord-023168-cd7adns8	418	20	.	.	.
cord-023168-cd7adns8	419	1	Acute	acute	JJ
cord-023168-cd7adns8	419	2	chest	chest	NN
cord-023168-cd7adns8	419	3	syndrome	syndrome	NN
cord-023168-cd7adns8	419	4	(	(	-LRB-
cord-023168-cd7adns8	419	5	ACS	ACS	NNP
cord-023168-cd7adns8	419	6	)	)	-RRB-
cord-023168-cd7adns8	419	7	is	be	VBZ
cord-023168-cd7adns8	419	8	defined	define	VBN
cord-023168-cd7adns8	419	9	as	as	IN
cord-023168-cd7adns8	419	10	a	a	DT
cord-023168-cd7adns8	419	11	new	new	JJ
cord-023168-cd7adns8	419	12	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	419	13	infiltrate	infiltrate	NN
cord-023168-cd7adns8	419	14	on	on	IN
cord-023168-cd7adns8	419	15	the	the	DT
cord-023168-cd7adns8	419	16	chest	chest	NN
cord-023168-cd7adns8	419	17	radiograph	radiograph	NN
cord-023168-cd7adns8	419	18	combined	combine	VBN
cord-023168-cd7adns8	419	19	with	with	IN
cord-023168-cd7adns8	419	20	one	one	CD
cord-023168-cd7adns8	419	21	or	or	CC
cord-023168-cd7adns8	419	22	more	more	JJR
cord-023168-cd7adns8	419	23	environment	environment	NN
cord-023168-cd7adns8	419	24	.	.	.
cord-023168-cd7adns8	420	1	Activation	activation	NN
cord-023168-cd7adns8	420	2	of	of	IN
cord-023168-cd7adns8	420	3	platelets	platelet	NNS
cord-023168-cd7adns8	420	4	and	and	CC
cord-023168-cd7adns8	420	5	the	the	DT
cord-023168-cd7adns8	420	6	coagulation	coagulation	NN
cord-023168-cd7adns8	420	7	system	system	NN
cord-023168-cd7adns8	420	8	also	also	RB
cord-023168-cd7adns8	420	9	contribute	contribute	VBP
cord-023168-cd7adns8	420	10	to	to	IN
cord-023168-cd7adns8	420	11	the	the	DT
cord-023168-cd7adns8	420	12	vaso	vaso	NN
cord-023168-cd7adns8	420	13	-	-	HYPH
cord-023168-cd7adns8	420	14	occlusion	occlusion	NN
cord-023168-cd7adns8	420	15	in	in	IN
cord-023168-cd7adns8	420	16	SCD	SCD	NNP
cord-023168-cd7adns8	420	17	.	.	.
cord-023168-cd7adns8	421	1	[	[	-LRB-
cord-023168-cd7adns8	421	2	82	82	CD
cord-023168-cd7adns8	421	3	]	]	-RRB-
cord-023168-cd7adns8	421	4	[	[	-LRB-
cord-023168-cd7adns8	421	5	83	83	CD
cord-023168-cd7adns8	421	6	]	]	-RRB-
cord-023168-cd7adns8	422	1	[	[	-LRB-
cord-023168-cd7adns8	422	2	84	84	CD
cord-023168-cd7adns8	422	3	]	]	-RRB-
cord-023168-cd7adns8	422	4	[	[	-LRB-
cord-023168-cd7adns8	422	5	85	85	CD
cord-023168-cd7adns8	422	6	]	]	-RRB-
cord-023168-cd7adns8	422	7	[	[	-LRB-
cord-023168-cd7adns8	422	8	86	86	CD
cord-023168-cd7adns8	422	9	]	]	-RRB-
cord-023168-cd7adns8	422	10	 	 	_SP
cord-023168-cd7adns8	423	1	Infants	infant	NNS
cord-023168-cd7adns8	423	2	with	with	IN
cord-023168-cd7adns8	423	3	SCD	SCD	NNP
cord-023168-cd7adns8	423	4	are	be	VBP
cord-023168-cd7adns8	423	5	protected	protect	VBN
cord-023168-cd7adns8	423	6	during	during	IN
cord-023168-cd7adns8	423	7	the	the	DT
cord-023168-cd7adns8	423	8	first	first	JJ
cord-023168-cd7adns8	423	9	few	few	JJ
cord-023168-cd7adns8	423	10	months	month	NNS
cord-023168-cd7adns8	423	11	of	of	IN
cord-023168-cd7adns8	423	12	life	life	NN
cord-023168-cd7adns8	423	13	by	by	IN
cord-023168-cd7adns8	423	14	the	the	DT
cord-023168-cd7adns8	423	15	high	high	JJ
cord-023168-cd7adns8	423	16	levels	level	NNS
cord-023168-cd7adns8	423	17	of	of	IN
cord-023168-cd7adns8	423	18	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	423	19	F	f	NN
cord-023168-cd7adns8	423	20	in	in	IN
cord-023168-cd7adns8	423	21	the	the	DT
cord-023168-cd7adns8	423	22	red	red	JJ
cord-023168-cd7adns8	423	23	cells	cell	NNS
cord-023168-cd7adns8	423	24	.	.	.
cord-023168-cd7adns8	424	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	424	2	usually	usually	RB
cord-023168-cd7adns8	424	3	develops	develop	VBZ
cord-023168-cd7adns8	424	4	by	by	IN
cord-023168-cd7adns8	424	5	3	3	CD
cord-023168-cd7adns8	424	6	months	month	NNS
cord-023168-cd7adns8	424	7	.	.	.
cord-023168-cd7adns8	425	1	At	at	IN
cord-023168-cd7adns8	425	2	all	all	DT
cord-023168-cd7adns8	425	3	ages	age	NNS
cord-023168-cd7adns8	425	4	,	,	,
cord-023168-cd7adns8	425	5	chronic	chronic	JJ
cord-023168-cd7adns8	425	6	haemolysis	haemolysis	NN
cord-023168-cd7adns8	425	7	of	of	IN
cord-023168-cd7adns8	425	8	abnormal	abnormal	JJ
cord-023168-cd7adns8	425	9	red	red	JJ
cord-023168-cd7adns8	425	10	cells	cell	NNS
cord-023168-cd7adns8	425	11	means	mean	VBZ
cord-023168-cd7adns8	425	12	that	that	IN
cord-023168-cd7adns8	425	13	SCD	SCD	NNP
cord-023168-cd7adns8	425	14	is	be	VBZ
cord-023168-cd7adns8	425	15	associated	associate	VBN
cord-023168-cd7adns8	425	16	with	with	IN
cord-023168-cd7adns8	425	17	steady	steady	JJ
cord-023168-cd7adns8	425	18	state	state	NN
cord-023168-cd7adns8	425	19	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	425	20	levels	level	NNS
cord-023168-cd7adns8	425	21	of	of	IN
cord-023168-cd7adns8	425	22	60	60	CD
cord-023168-cd7adns8	425	23	-	-	SYM
cord-023168-cd7adns8	425	24	80	80	CD
cord-023168-cd7adns8	425	25	g	g	NN
cord-023168-cd7adns8	425	26	/	/	SYM
cord-023168-cd7adns8	425	27	L.	L.	NNP
cord-023168-cd7adns8	426	1	Although	although	IN
cord-023168-cd7adns8	426	2	any	any	DT
cord-023168-cd7adns8	426	3	organ	organ	NN
cord-023168-cd7adns8	426	4	can	can	MD
cord-023168-cd7adns8	426	5	be	be	VB
cord-023168-cd7adns8	426	6	affected	affect	VBN
cord-023168-cd7adns8	426	7	by	by	IN
cord-023168-cd7adns8	426	8	SCD	SCD	NNP
cord-023168-cd7adns8	426	9	and	and	CC
cord-023168-cd7adns8	426	10	complications	complication	NNS
cord-023168-cd7adns8	426	11	can	can	MD
cord-023168-cd7adns8	426	12	occur	occur	VB
cord-023168-cd7adns8	426	13	at	at	IN
cord-023168-cd7adns8	426	14	any	any	DT
cord-023168-cd7adns8	426	15	age	age	NN
cord-023168-cd7adns8	426	16	,	,	,
cord-023168-cd7adns8	426	17	certain	certain	JJ
cord-023168-cd7adns8	426	18	features	feature	NNS
cord-023168-cd7adns8	426	19	tend	tend	VBP
cord-023168-cd7adns8	426	20	to	to	TO
cord-023168-cd7adns8	426	21	predominate	predominate	VB
cord-023168-cd7adns8	426	22	in	in	IN
cord-023168-cd7adns8	426	23	different	different	JJ
cord-023168-cd7adns8	426	24	age	age	NN
cord-023168-cd7adns8	426	25	groups	group	NNS
cord-023168-cd7adns8	426	26	(	(	-LRB-
cord-023168-cd7adns8	426	27	Box	Box	NNP
cord-023168-cd7adns8	426	28	65.7	65.7	CD
cord-023168-cd7adns8	426	29	)	)	-RRB-
cord-023168-cd7adns8	426	30	.	.	.
cord-023168-cd7adns8	427	1	Pain	pain	NN
cord-023168-cd7adns8	427	2	is	be	VBZ
cord-023168-cd7adns8	427	3	the	the	DT
cord-023168-cd7adns8	427	4	hallmark	hallmark	NN
cord-023168-cd7adns8	427	5	of	of	IN
cord-023168-cd7adns8	427	6	SCD	SCD	NNP
cord-023168-cd7adns8	427	7	87	87	CD
cord-023168-cd7adns8	427	8	and	and	CC
cord-023168-cd7adns8	427	9	four	four	CD
cord-023168-cd7adns8	427	10	different	different	JJ
cord-023168-cd7adns8	427	11	patterns	pattern	NNS
cord-023168-cd7adns8	427	12	of	of	IN
cord-023168-cd7adns8	427	13	pain	pain	NN
cord-023168-cd7adns8	427	14	have	have	VBP
cord-023168-cd7adns8	427	15	been	be	VBN
cord-023168-cd7adns8	427	16	described	describe	VBN
cord-023168-cd7adns8	427	17	with	with	IN
cord-023168-cd7adns8	427	18	SCD	SCD	NNP
cord-023168-cd7adns8	427	19	each	each	DT
cord-023168-cd7adns8	427	20	with	with	IN
cord-023168-cd7adns8	427	21	different	different	JJ
cord-023168-cd7adns8	427	22	underlying	underlying	JJ
cord-023168-cd7adns8	427	23	mechanisms	mechanism	NNS
cord-023168-cd7adns8	427	24	:	:	:
cord-023168-cd7adns8	427	25	88	88	CD
cord-023168-cd7adns8	428	1	•	•	NNP
cord-023168-cd7adns8	428	2	Vaso	Vaso	NNP
cord-023168-cd7adns8	428	3	-	-	HYPH
cord-023168-cd7adns8	428	4	occlusive	occlusive	JJ
cord-023168-cd7adns8	428	5	(	(	-LRB-
cord-023168-cd7adns8	428	6	acute	acute	JJ
cord-023168-cd7adns8	428	7	and	and	CC
cord-023168-cd7adns8	428	8	intermittent	intermittent	JJ
cord-023168-cd7adns8	428	9	)	)	-RRB-
cord-023168-cd7adns8	429	1	•	•	NNP
cord-023168-cd7adns8	430	1	Pain	pain	NN
cord-023168-cd7adns8	430	2	from	from	IN
cord-023168-cd7adns8	430	3	bone	bone	NN
cord-023168-cd7adns8	430	4	and	and	CC
cord-023168-cd7adns8	430	5	tissue	tissue	NN
cord-023168-cd7adns8	430	6	necrosis	necrosis	NN
cord-023168-cd7adns8	430	7	(	(	-LRB-
cord-023168-cd7adns8	430	8	chronic	chronic	NN
cord-023168-cd7adns8	430	9	)	)	-RRB-
cord-023168-cd7adns8	431	1	•	•	NNP
cord-023168-cd7adns8	432	1	Neuroplasticity	neuroplasticity	NN
cord-023168-cd7adns8	432	2	(	(	-LRB-
cord-023168-cd7adns8	432	3	chronic	chronic	JJ
cord-023168-cd7adns8	432	4	,	,	,
cord-023168-cd7adns8	432	5	neuropathic	neuropathic	JJ
cord-023168-cd7adns8	432	6	)	)	-RRB-
cord-023168-cd7adns8	432	7	-functional	-functional	JJ
cord-023168-cd7adns8	432	8	brain	brain	NN
cord-023168-cd7adns8	432	9	changes	change	NNS
cord-023168-cd7adns8	433	1	•	•	NNP
cord-023168-cd7adns8	434	1	Opioid	opioid	NN
cord-023168-cd7adns8	434	2	-	-	HYPH
cord-023168-cd7adns8	434	3	induced	induce	VBN
cord-023168-cd7adns8	434	4	hyperalgesia	hyperalgesia	NN
cord-023168-cd7adns8	434	5	(	(	-LRB-
cord-023168-cd7adns8	434	6	acute	acute	JJ
cord-023168-cd7adns8	434	7	or	or	CC
cord-023168-cd7adns8	434	8	chronic	chronic	JJ
cord-023168-cd7adns8	434	9	)	)	-RRB-
cord-023168-cd7adns8	434	10	.	.	.
cord-023168-cd7adns8	435	1	Painful	painful	JJ
cord-023168-cd7adns8	435	2	crises	crisis	NNS
cord-023168-cd7adns8	435	3	often	often	RB
cord-023168-cd7adns8	435	4	start	start	VBP
cord-023168-cd7adns8	435	5	in	in	IN
cord-023168-cd7adns8	435	6	young	young	JJ
cord-023168-cd7adns8	435	7	children	child	NNS
cord-023168-cd7adns8	435	8	as	as	IN
cord-023168-cd7adns8	435	9	dactylitis	dactylitis	NNP
cord-023168-cd7adns8	435	10	or	or	CC
cord-023168-cd7adns8	435	11	handfoot	handfoot	NNP
cord-023168-cd7adns8	435	12	syndrome	syndrome	NN
cord-023168-cd7adns8	435	13	,	,	,
cord-023168-cd7adns8	435	14	in	in	IN
cord-023168-cd7adns8	435	15	which	which	WDT
cord-023168-cd7adns8	435	16	painful	painful	JJ
cord-023168-cd7adns8	435	17	swelling	swelling	NN
cord-023168-cd7adns8	435	18	of	of	IN
cord-023168-cd7adns8	435	19	the	the	DT
cord-023168-cd7adns8	435	20	hands	hand	NNS
cord-023168-cd7adns8	435	21	and	and	CC
cord-023168-cd7adns8	435	22	feet	foot	NNS
cord-023168-cd7adns8	435	23	results	result	NNS
cord-023168-cd7adns8	435	24	from	from	IN
cord-023168-cd7adns8	435	25	the	the	DT
cord-023168-cd7adns8	435	26	inflammation	inflammation	NN
cord-023168-cd7adns8	435	27	of	of	IN
cord-023168-cd7adns8	435	28	metacarpal	metacarpal	NN
cord-023168-cd7adns8	435	29	and	and	CC
cord-023168-cd7adns8	435	30	metatarsal	metatarsal	NN
cord-023168-cd7adns8	435	31	periosteum	periosteum	NN
cord-023168-cd7adns8	435	32	.	.	.
cord-023168-cd7adns8	436	1	These	these	DT
cord-023168-cd7adns8	436	2	crises	crisis	NNS
cord-023168-cd7adns8	436	3	are	be	VBP
cord-023168-cd7adns8	436	4	the	the	DT
cord-023168-cd7adns8	436	5	result	result	NN
cord-023168-cd7adns8	436	6	of	of	IN
cord-023168-cd7adns8	436	7	vaso	vaso	NNP
cord-023168-cd7adns8	436	8	-	-	HYPH
cord-023168-cd7adns8	436	9	occlusion	occlusion	NN
cord-023168-cd7adns8	436	10	of	of	IN
cord-023168-cd7adns8	436	11	the	the	DT
cord-023168-cd7adns8	436	12	bone	bone	NN
cord-023168-cd7adns8	436	13	marrow	marrow	NN
cord-023168-cd7adns8	436	14	causing	cause	VBG
cord-023168-cd7adns8	436	15	bone	bone	NN
cord-023168-cd7adns8	436	16	infarction	infarction	NN
cord-023168-cd7adns8	436	17	and	and	CC
cord-023168-cd7adns8	436	18	release	release	NN
cord-023168-cd7adns8	436	19	of	of	IN
cord-023168-cd7adns8	436	20	mediators	mediator	NNS
cord-023168-cd7adns8	436	21	that	that	WDT
cord-023168-cd7adns8	436	22	activate	activate	VBP
cord-023168-cd7adns8	436	23	pain	pain	NN
cord-023168-cd7adns8	436	24	receptors	receptor	NNS
cord-023168-cd7adns8	436	25	.	.	.
cord-023168-cd7adns8	437	1	82	82	CD
cord-023168-cd7adns8	438	1	The	the	DT
cord-023168-cd7adns8	438	2	number	number	NN
cord-023168-cd7adns8	438	3	,	,	,
cord-023168-cd7adns8	438	4	severity	severity	NN
cord-023168-cd7adns8	438	5	and	and	CC
cord-023168-cd7adns8	438	6	frequency	frequency	NN
cord-023168-cd7adns8	438	7	of	of	IN
cord-023168-cd7adns8	438	8	painful	painful	JJ
cord-023168-cd7adns8	438	9	episodes	episode	NNS
cord-023168-cd7adns8	438	10	vary	vary	VBP
cord-023168-cd7adns8	438	11	widely	widely	RB
cord-023168-cd7adns8	438	12	in	in	IN
cord-023168-cd7adns8	438	13	individuals	individual	NNS
cord-023168-cd7adns8	438	14	.	.	.
cord-023168-cd7adns8	439	1	Half	half	NN
cord-023168-cd7adns8	439	2	may	may	MD
cord-023168-cd7adns8	439	3	never	never	RB
cord-023168-cd7adns8	439	4	have	have	VB
cord-023168-cd7adns8	439	5	any	any	DT
cord-023168-cd7adns8	439	6	episodes	episode	NNS
cord-023168-cd7adns8	439	7	whereas	whereas	IN
cord-023168-cd7adns8	439	8	about	about	RB
cord-023168-cd7adns8	439	9	3	3	CD
cord-023168-cd7adns8	439	10	%	%	NN
cord-023168-cd7adns8	439	11	may	may	MD
cord-023168-cd7adns8	439	12	need	need	VB
cord-023168-cd7adns8	439	13	hospital	hospital	NN
cord-023168-cd7adns8	439	14	admission	admission	NN
cord-023168-cd7adns8	439	15	up	up	IN
cord-023168-cd7adns8	439	16	to	to	TO
cord-023168-cd7adns8	439	17	6	6	CD
cord-023168-cd7adns8	439	18	times	time	NNS
cord-023168-cd7adns8	439	19	a	a	DT
cord-023168-cd7adns8	439	20	year	year	NN
cord-023168-cd7adns8	439	21	.	.	.
cord-023168-cd7adns8	440	1	89	89	CD
cord-023168-cd7adns8	440	2	More	More	JJR
cord-023168-cd7adns8	440	3	than	than	IN
cord-023168-cd7adns8	440	4	three	three	CD
cord-023168-cd7adns8	440	5	pain	pain	NN
cord-023168-cd7adns8	440	6	episodes	episode	NNS
cord-023168-cd7adns8	440	7	requiring	require	VBG
cord-023168-cd7adns8	440	8	hospitalization	hospitalization	NN
cord-023168-cd7adns8	440	9	per	per	IN
cord-023168-cd7adns8	440	10	year	year	NN
cord-023168-cd7adns8	440	11	is	be	VBZ
cord-023168-cd7adns8	440	12	associated	associate	VBN
cord-023168-cd7adns8	440	13	with	with	IN
cord-023168-cd7adns8	440	14	increased	increase	VBN
cord-023168-cd7adns8	440	15	mortality	mortality	NN
cord-023168-cd7adns8	440	16	among	among	IN
cord-023168-cd7adns8	440	17	patients	patient	NNS
cord-023168-cd7adns8	440	18	over	over	IN
cord-023168-cd7adns8	440	19	20	20	CD
cord-023168-cd7adns8	440	20	years	year	NNS
cord-023168-cd7adns8	440	21	old	old	JJ
cord-023168-cd7adns8	440	22	.	.	.
cord-023168-cd7adns8	441	1	In	in	IN
cord-023168-cd7adns8	441	2	under	under	RB
cord-023168-cd7adns8	441	3	-	-	HYPH
cord-023168-cd7adns8	441	4	resourced	resource	VBN
cord-023168-cd7adns8	441	5	settings	setting	NNS
cord-023168-cd7adns8	441	6	,	,	,
cord-023168-cd7adns8	441	7	hospital	hospital	NN
cord-023168-cd7adns8	441	8	visits	visit	NNS
cord-023168-cd7adns8	441	9	underestimate	underestimate	VBP
cord-023168-cd7adns8	441	10	the	the	DT
cord-023168-cd7adns8	441	11	frequency	frequency	NN
cord-023168-cd7adns8	441	12	of	of	IN
cord-023168-cd7adns8	441	13	pain	pain	NN
cord-023168-cd7adns8	441	14	BOX	BOX	NNP
cord-023168-cd7adns8	441	15	manifestations	manifestation	NNS
cord-023168-cd7adns8	441	16	such	such	JJ
cord-023168-cd7adns8	441	17	as	as	IN
cord-023168-cd7adns8	441	18	fever	fever	NN
cord-023168-cd7adns8	441	19	,	,	,
cord-023168-cd7adns8	441	20	cough	cough	NN
cord-023168-cd7adns8	441	21	,	,	,
cord-023168-cd7adns8	441	22	sputum	sputum	NN
cord-023168-cd7adns8	441	23	production	production	NN
cord-023168-cd7adns8	441	24	,	,	,
cord-023168-cd7adns8	441	25	tachypnoea	tachypnoea	NNP
cord-023168-cd7adns8	441	26	,	,	,
cord-023168-cd7adns8	441	27	dyspnoea	dyspnoea	NNS
cord-023168-cd7adns8	441	28	or	or	CC
cord-023168-cd7adns8	441	29	new	new	JJ
cord-023168-cd7adns8	441	30	-	-	HYPH
cord-023168-cd7adns8	441	31	onset	onset	NN
cord-023168-cd7adns8	441	32	hypoxia	hypoxia	NN
cord-023168-cd7adns8	441	33	.	.	.
cord-023168-cd7adns8	442	1	94	94	CD
cord-023168-cd7adns8	443	1	ACS	ACS	NNP
cord-023168-cd7adns8	443	2	is	be	VBZ
cord-023168-cd7adns8	443	3	the	the	DT
cord-023168-cd7adns8	443	4	most	most	RBS
cord-023168-cd7adns8	443	5	common	common	JJ
cord-023168-cd7adns8	443	6	cause	cause	NN
cord-023168-cd7adns8	443	7	of	of	IN
cord-023168-cd7adns8	443	8	death	death	NN
cord-023168-cd7adns8	443	9	in	in	IN
cord-023168-cd7adns8	443	10	SCD	SCD	NNP
cord-023168-cd7adns8	443	11	patients	patient	NNS
cord-023168-cd7adns8	443	12	and	and	CC
cord-023168-cd7adns8	443	13	a	a	DT
cord-023168-cd7adns8	443	14	frequent	frequent	JJ
cord-023168-cd7adns8	443	15	cause	cause	NN
cord-023168-cd7adns8	443	16	of	of	IN
cord-023168-cd7adns8	443	17	hospitalization	hospitalization	NN
cord-023168-cd7adns8	443	18	,	,	,
cord-023168-cd7adns8	443	19	second	second	RB
cord-023168-cd7adns8	443	20	only	only	RB
cord-023168-cd7adns8	443	21	to	to	IN
cord-023168-cd7adns8	443	22	painful	painful	JJ
cord-023168-cd7adns8	443	23	crisis	crisis	NN
cord-023168-cd7adns8	443	24	.	.	.
cord-023168-cd7adns8	444	1	Mortality	mortality	NN
cord-023168-cd7adns8	444	2	in	in	IN
cord-023168-cd7adns8	444	3	patients	patient	NNS
cord-023168-cd7adns8	444	4	with	with	IN
cord-023168-cd7adns8	444	5	ACS	ACS	NNP
cord-023168-cd7adns8	444	6	in	in	IN
cord-023168-cd7adns8	444	7	a	a	DT
cord-023168-cd7adns8	444	8	wealthy	wealthy	JJ
cord-023168-cd7adns8	444	9	country	country	NN
cord-023168-cd7adns8	444	10	setting	setting	NN
cord-023168-cd7adns8	444	11	is	be	VBZ
cord-023168-cd7adns8	444	12	1	1	CD
cord-023168-cd7adns8	444	13	%	%	NN
cord-023168-cd7adns8	444	14	in	in	IN
cord-023168-cd7adns8	444	15	children	child	NNS
cord-023168-cd7adns8	444	16	and	and	CC
cord-023168-cd7adns8	444	17	4.3	4.3	CD
cord-023168-cd7adns8	444	18	%	%	NN
cord-023168-cd7adns8	444	19	in	in	IN
cord-023168-cd7adns8	444	20	adults	adult	NNS
cord-023168-cd7adns8	444	21	.	.	.
cord-023168-cd7adns8	445	1	95	95	CD
cord-023168-cd7adns8	446	1	The	the	DT
cord-023168-cd7adns8	446	2	peak	peak	NN
cord-023168-cd7adns8	446	3	incidence	incidence	NN
cord-023168-cd7adns8	446	4	for	for	IN
cord-023168-cd7adns8	446	5	ACS	ACS	NNP
cord-023168-cd7adns8	446	6	is	be	VBZ
cord-023168-cd7adns8	446	7	2	2	CD
cord-023168-cd7adns8	446	8	-	-	SYM
cord-023168-cd7adns8	446	9	4	4	CD
cord-023168-cd7adns8	446	10	years	year	NNS
cord-023168-cd7adns8	446	11	of	of	IN
cord-023168-cd7adns8	446	12	age	age	NN
cord-023168-cd7adns8	446	13	and	and	CC
cord-023168-cd7adns8	446	14	gradually	gradually	RB
cord-023168-cd7adns8	446	15	declines	decline	VBZ
cord-023168-cd7adns8	446	16	to	to	IN
cord-023168-cd7adns8	446	17	8.8	8.8	CD
cord-023168-cd7adns8	446	18	per	per	IN
cord-023168-cd7adns8	446	19	100	100	CD
cord-023168-cd7adns8	446	20	patient	patient	NN
cord-023168-cd7adns8	446	21	-	-	HYPH
cord-023168-cd7adns8	446	22	years	year	NNS
cord-023168-cd7adns8	446	23	in	in	IN
cord-023168-cd7adns8	446	24	subjects	subject	NNS
cord-023168-cd7adns8	446	25	older	old	JJR
cord-023168-cd7adns8	446	26	than	than	IN
cord-023168-cd7adns8	446	27	20	20	CD
cord-023168-cd7adns8	446	28	years	year	NNS
cord-023168-cd7adns8	446	29	.	.	.
cord-023168-cd7adns8	447	1	96	96	CD
cord-023168-cd7adns8	447	2	,	,	,
cord-023168-cd7adns8	447	3	97	97	CD
cord-023168-cd7adns8	447	4	Fever	fever	NN
cord-023168-cd7adns8	447	5	and	and	CC
cord-023168-cd7adns8	447	6	cough	cough	NN
cord-023168-cd7adns8	447	7	are	be	VBP
cord-023168-cd7adns8	447	8	more	more	RBR
cord-023168-cd7adns8	447	9	common	common	JJ
cord-023168-cd7adns8	447	10	in	in	IN
cord-023168-cd7adns8	447	11	children	child	NNS
cord-023168-cd7adns8	447	12	with	with	IN
cord-023168-cd7adns8	447	13	ACS	ACS	NNP
cord-023168-cd7adns8	447	14	and	and	CC
cord-023168-cd7adns8	447	15	chest	chest	NN
cord-023168-cd7adns8	447	16	pain	pain	NN
cord-023168-cd7adns8	447	17	and	and	CC
cord-023168-cd7adns8	447	18	dyspnoea	dyspnoea	NNS
cord-023168-cd7adns8	447	19	are	be	VBP
cord-023168-cd7adns8	447	20	more	more	RBR
cord-023168-cd7adns8	447	21	common	common	JJ
cord-023168-cd7adns8	447	22	in	in	IN
cord-023168-cd7adns8	447	23	adults	adult	NNS
cord-023168-cd7adns8	447	24	.	.	.
cord-023168-cd7adns8	448	1	96	96	CD
cord-023168-cd7adns8	449	1	ACS	ACS	NNP
cord-023168-cd7adns8	449	2	is	be	VBZ
cord-023168-cd7adns8	449	3	often	often	RB
cord-023168-cd7adns8	449	4	preceded	precede	VBN
cord-023168-cd7adns8	449	5	by	by	IN
cord-023168-cd7adns8	449	6	febrile	febrile	JJ
cord-023168-cd7adns8	449	7	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	449	8	infection	infection	NN
cord-023168-cd7adns8	449	9	in	in	IN
cord-023168-cd7adns8	449	10	children	child	NNS
cord-023168-cd7adns8	449	11	and	and	CC
cord-023168-cd7adns8	449	12	by	by	IN
cord-023168-cd7adns8	449	13	vaso	vaso	JJ
cord-023168-cd7adns8	449	14	-	-	HYPH
cord-023168-cd7adns8	449	15	occlusive	occlusive	JJ
cord-023168-cd7adns8	449	16	pain	pain	NN
cord-023168-cd7adns8	449	17	crisis	crisis	NN
cord-023168-cd7adns8	449	18	and	and	CC
cord-023168-cd7adns8	449	19	lung	lung	NN
cord-023168-cd7adns8	449	20	infarction	infarction	NN
cord-023168-cd7adns8	449	21	in	in	IN
cord-023168-cd7adns8	449	22	adults	adult	NNS
cord-023168-cd7adns8	449	23	.	.	.
cord-023168-cd7adns8	450	1	It	-PRON-	PRP
cord-023168-cd7adns8	450	2	is	be	VBZ
cord-023168-cd7adns8	450	3	important	important	JJ
cord-023168-cd7adns8	450	4	to	to	TO
cord-023168-cd7adns8	450	5	note	note	VB
cord-023168-cd7adns8	450	6	that	that	IN
cord-023168-cd7adns8	450	7	although	although	IN
cord-023168-cd7adns8	450	8	tachypnoea	tachypnoea	NNP
cord-023168-cd7adns8	450	9	,	,	,
cord-023168-cd7adns8	450	10	wheezing	wheezing	NN
cord-023168-cd7adns8	450	11	and	and	CC
cord-023168-cd7adns8	450	12	features	feature	NNS
cord-023168-cd7adns8	450	13	of	of	IN
cord-023168-cd7adns8	450	14	chest	chest	NN
cord-023168-cd7adns8	450	15	infection	infection	NN
cord-023168-cd7adns8	450	16	may	may	MD
cord-023168-cd7adns8	450	17	be	be	VB
cord-023168-cd7adns8	450	18	identified	identify	VBN
cord-023168-cd7adns8	450	19	,	,	,
cord-023168-cd7adns8	450	20	a	a	DT
cord-023168-cd7adns8	450	21	third	third	NN
cord-023168-cd7adns8	450	22	of	of	IN
cord-023168-cd7adns8	450	23	the	the	DT
cord-023168-cd7adns8	450	24	patients	patient	NNS
cord-023168-cd7adns8	450	25	may	may	MD
cord-023168-cd7adns8	450	26	have	have	VB
cord-023168-cd7adns8	450	27	a	a	DT
cord-023168-cd7adns8	450	28	normal	normal	JJ
cord-023168-cd7adns8	450	29	physical	physical	JJ
cord-023168-cd7adns8	450	30	examination	examination	NN
cord-023168-cd7adns8	450	31	.	.	.
cord-023168-cd7adns8	451	1	More	More	JJR
cord-023168-cd7adns8	451	2	than	than	IN
cord-023168-cd7adns8	451	3	one	one	CD
cord-023168-cd7adns8	451	4	-	-	HYPH
cord-023168-cd7adns8	451	5	third	third	NN
cord-023168-cd7adns8	451	6	of	of	IN
cord-023168-cd7adns8	451	7	patients	patient	NNS
cord-023168-cd7adns8	451	8	with	with	IN
cord-023168-cd7adns8	451	9	ACS	ACS	NNP
cord-023168-cd7adns8	451	10	are	be	VBP
cord-023168-cd7adns8	451	11	hypoxaemic	hypoxaemic	JJ
cord-023168-cd7adns8	451	12	(	(	-LRB-
cord-023168-cd7adns8	451	13	oxygen	oxygen	NN
cord-023168-cd7adns8	451	14	saturation	saturation	NN
cord-023168-cd7adns8	451	15	<	<	XX
cord-023168-cd7adns8	451	16	90	90	CD
cord-023168-cd7adns8	451	17	%	%	NN
cord-023168-cd7adns8	451	18	)	)	-RRB-
cord-023168-cd7adns8	451	19	.	.	.
cord-023168-cd7adns8	452	1	98	98	CD
cord-023168-cd7adns8	453	1	Chest	chest	NN
cord-023168-cd7adns8	453	2	radiography	radiography	NN
cord-023168-cd7adns8	453	3	is	be	VBZ
cord-023168-cd7adns8	453	4	essential	essential	JJ
cord-023168-cd7adns8	453	5	although	although	IN
cord-023168-cd7adns8	453	6	infiltrates	infiltrate	NNS
cord-023168-cd7adns8	453	7	may	may	MD
cord-023168-cd7adns8	453	8	lag	lag	VB
cord-023168-cd7adns8	453	9	behind	behind	IN
cord-023168-cd7adns8	453	10	clinical	clinical	JJ
cord-023168-cd7adns8	453	11	symptoms	symptom	NNS
cord-023168-cd7adns8	453	12	by	by	IN
cord-023168-cd7adns8	453	13	up	up	IN
cord-023168-cd7adns8	453	14	to	to	TO
cord-023168-cd7adns8	453	15	3	3	CD
cord-023168-cd7adns8	453	16	days	day	NNS
cord-023168-cd7adns8	453	17	.	.	.
cord-023168-cd7adns8	454	1	Repeat	repeat	VB
cord-023168-cd7adns8	454	2	chest	chest	NN
cord-023168-cd7adns8	455	1	X	X	NNS
cord-023168-cd7adns8	455	2	-	-	NNS
cord-023168-cd7adns8	455	3	rays	ray	NNS
cord-023168-cd7adns8	455	4	are	be	VBP
cord-023168-cd7adns8	455	5	recommended	recommend	VBN
cord-023168-cd7adns8	455	6	if	if	IN
cord-023168-cd7adns8	455	7	there	there	EX
cord-023168-cd7adns8	455	8	is	be	VBZ
cord-023168-cd7adns8	455	9	a	a	DT
cord-023168-cd7adns8	455	10	strong	strong	JJ
cord-023168-cd7adns8	455	11	clinical	clinical	JJ
cord-023168-cd7adns8	455	12	suspicion	suspicion	NN
cord-023168-cd7adns8	455	13	of	of	IN
cord-023168-cd7adns8	455	14	ACS	ACS	NNP
cord-023168-cd7adns8	455	15	.	.	.
cord-023168-cd7adns8	456	1	Bilateral	bilateral	JJ
cord-023168-cd7adns8	456	2	infiltrates	infiltrate	NNS
cord-023168-cd7adns8	456	3	or	or	CC
cord-023168-cd7adns8	456	4	involvement	involvement	NN
cord-023168-cd7adns8	456	5	of	of	IN
cord-023168-cd7adns8	456	6	multiple	multiple	JJ
cord-023168-cd7adns8	456	7	lobes	lobe	NNS
cord-023168-cd7adns8	456	8	may	may	MD
cord-023168-cd7adns8	456	9	predict	predict	VB
cord-023168-cd7adns8	456	10	a	a	DT
cord-023168-cd7adns8	456	11	poorer	poor	JJR
cord-023168-cd7adns8	456	12	prognosis	prognosis	NN
cord-023168-cd7adns8	456	13	.	.	.
cord-023168-cd7adns8	457	1	Risk	risk	NN
cord-023168-cd7adns8	457	2	factors	factor	NNS
cord-023168-cd7adns8	457	3	for	for	IN
cord-023168-cd7adns8	457	4	ACS	ACS	NNP
cord-023168-cd7adns8	457	5	(	(	-LRB-
cord-023168-cd7adns8	457	6	Box	Box	NNP
cord-023168-cd7adns8	457	7	65.9	65.9	CD
cord-023168-cd7adns8	457	8	)	)	-RRB-
cord-023168-cd7adns8	457	9	include	include	VBP
cord-023168-cd7adns8	457	10	fat	fat	JJ
cord-023168-cd7adns8	457	11	embolus	embolus	NN
cord-023168-cd7adns8	457	12	which	which	WDT
cord-023168-cd7adns8	457	13	can	can	MD
cord-023168-cd7adns8	457	14	be	be	VB
cord-023168-cd7adns8	457	15	confirmed	confirm	VBN
cord-023168-cd7adns8	457	16	by	by	IN
cord-023168-cd7adns8	457	17	finding	find	VBG
cord-023168-cd7adns8	457	18	stainable	stainable	JJ
cord-023168-cd7adns8	457	19	fat	fat	NN
cord-023168-cd7adns8	457	20	in	in	IN
cord-023168-cd7adns8	457	21	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	457	22	macrophages	macrophage	NNS
cord-023168-cd7adns8	457	23	.	.	.
cord-023168-cd7adns8	458	1	99	99	CD
cord-023168-cd7adns8	458	2	Chronic	chronic	JJ
cord-023168-cd7adns8	458	3	complications	complication	NNS
cord-023168-cd7adns8	458	4	such	such	JJ
cord-023168-cd7adns8	458	5	as	as	IN
cord-023168-cd7adns8	458	6	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	458	7	hypertension	hypertension	NN
cord-023168-cd7adns8	458	8	occur	occur	VBP
cord-023168-cd7adns8	458	9	in	in	IN
cord-023168-cd7adns8	458	10	as	as	RB
cord-023168-cd7adns8	458	11	many	many	JJ
cord-023168-cd7adns8	458	12	as	as	IN
cord-023168-cd7adns8	458	13	60	60	CD
cord-023168-cd7adns8	458	14	%	%	NN
cord-023168-cd7adns8	458	15	of	of	IN
cord-023168-cd7adns8	458	16	patients	patient	NNS
cord-023168-cd7adns8	458	17	and	and	CC
cord-023168-cd7adns8	458	18	do	do	VBP
cord-023168-cd7adns8	458	19	not	not	RB
cord-023168-cd7adns8	458	20	appear	appear	VB
cord-023168-cd7adns8	458	21	to	to	TO
cord-023168-cd7adns8	458	22	be	be	VB
cord-023168-cd7adns8	458	23	associated	associate	VBN
cord-023168-cd7adns8	458	24	with	with	IN
cord-023168-cd7adns8	458	25	prior	prior	JJ
cord-023168-cd7adns8	458	26	episodes	episode	NNS
cord-023168-cd7adns8	458	27	of	of	IN
cord-023168-cd7adns8	458	28	ACS	ACS	NNP
cord-023168-cd7adns8	458	29	.	.	.
cord-023168-cd7adns8	459	1	High	high	JJ
cord-023168-cd7adns8	459	2	serum	serum	NN
cord-023168-cd7adns8	459	3	phospholipase	phospholipase	NN
cord-023168-cd7adns8	459	4	A2	A2	NNP
cord-023168-cd7adns8	459	5	,	,	,
cord-023168-cd7adns8	459	6	and	and	CC
cord-023168-cd7adns8	459	7	the	the	DT
cord-023168-cd7adns8	459	8	surrogate	surrogate	JJ
cord-023168-cd7adns8	459	9	marker	marker	NN
cord-023168-cd7adns8	459	10	C	C	NNP
cord-023168-cd7adns8	459	11	-	-	HYPH
cord-023168-cd7adns8	459	12	reactive	reactive	JJ
cord-023168-cd7adns8	459	13	protein	protein	NN
cord-023168-cd7adns8	459	14	,	,	,
cord-023168-cd7adns8	459	15	have	have	VBP
cord-023168-cd7adns8	459	16	been	be	VBN
cord-023168-cd7adns8	459	17	noted	note	VBN
cord-023168-cd7adns8	459	18	in	in	IN
cord-023168-cd7adns8	459	19	patients	patient	NNS
cord-023168-cd7adns8	459	20	admitted	admit	VBN
cord-023168-cd7adns8	459	21	with	with	IN
cord-023168-cd7adns8	459	22	vaso	vaso	JJ
cord-023168-cd7adns8	459	23	-	-	HYPH
cord-023168-cd7adns8	459	24	occlusive	occlusive	JJ
cord-023168-cd7adns8	459	25	crisis	crisis	NN
cord-023168-cd7adns8	459	26	24	24	CD
cord-023168-cd7adns8	459	27	-	-	SYM
cord-023168-cd7adns8	459	28	48	48	CD
cord-023168-cd7adns8	459	29	hours	hour	NNS
cord-023168-cd7adns8	459	30	before	before	IN
cord-023168-cd7adns8	459	31	the	the	DT
cord-023168-cd7adns8	459	32	development	development	NN
cord-023168-cd7adns8	459	33	of	of	IN
cord-023168-cd7adns8	459	34	ACS	ACS	NNP
cord-023168-cd7adns8	459	35	.	.	.
cord-023168-cd7adns8	460	1	100	100	CD
cord-023168-cd7adns8	460	2	,	,	,
cord-023168-cd7adns8	460	3	101	101	CD
cord-023168-cd7adns8	460	4	Stroke	stroke	NN
cord-023168-cd7adns8	460	5	Neurological	neurological	JJ
cord-023168-cd7adns8	460	6	complications	complication	NNS
cord-023168-cd7adns8	460	7	occur	occur	VBP
cord-023168-cd7adns8	460	8	in	in	IN
cord-023168-cd7adns8	460	9	at	at	RB
cord-023168-cd7adns8	460	10	least	least	RBS
cord-023168-cd7adns8	460	11	25	25	CD
cord-023168-cd7adns8	460	12	%	%	NN
cord-023168-cd7adns8	460	13	of	of	IN
cord-023168-cd7adns8	460	14	patients	patient	NNS
cord-023168-cd7adns8	460	15	with	with	IN
cord-023168-cd7adns8	460	16	SCD	SCD	NNP
cord-023168-cd7adns8	460	17	and	and	CC
cord-023168-cd7adns8	460	18	SCD	SCD	NNP
cord-023168-cd7adns8	461	1	is	be	VBZ
cord-023168-cd7adns8	461	2	one	one	CD
cord-023168-cd7adns8	461	3	of	of	IN
cord-023168-cd7adns8	461	4	the	the	DT
cord-023168-cd7adns8	461	5	most	most	RBS
cord-023168-cd7adns8	461	6	common	common	JJ
cord-023168-cd7adns8	461	7	causes	cause	NNS
cord-023168-cd7adns8	461	8	of	of	IN
cord-023168-cd7adns8	461	9	stroke	stroke	NN
cord-023168-cd7adns8	461	10	in	in	IN
cord-023168-cd7adns8	461	11	children	child	NNS
cord-023168-cd7adns8	461	12	.	.	.
cord-023168-cd7adns8	462	1	102	102	CD
cord-023168-cd7adns8	462	2	,	,	,
cord-023168-cd7adns8	462	3	103	103	CD
cord-023168-cd7adns8	463	1	In	in	IN
cord-023168-cd7adns8	463	2	SCD	SCD	NNP
cord-023168-cd7adns8	463	3	,	,	,
cord-023168-cd7adns8	463	4	the	the	DT
cord-023168-cd7adns8	463	5	risk	risk	NN
cord-023168-cd7adns8	463	6	of	of	IN
cord-023168-cd7adns8	463	7	having	have	VBG
cord-023168-cd7adns8	463	8	a	a	DT
cord-023168-cd7adns8	463	9	first	first	JJ
cord-023168-cd7adns8	463	10	stroke	stroke	NN
cord-023168-cd7adns8	463	11	is	be	VBZ
cord-023168-cd7adns8	463	12	11	11	CD
cord-023168-cd7adns8	463	13	%	%	NN
cord-023168-cd7adns8	463	14	by	by	IN
cord-023168-cd7adns8	463	15	the	the	DT
cord-023168-cd7adns8	463	16	age	age	NN
cord-023168-cd7adns8	463	17	of	of	IN
cord-023168-cd7adns8	463	18	20	20	CD
cord-023168-cd7adns8	463	19	,	,	,
cord-023168-cd7adns8	463	20	15	15	CD
cord-023168-cd7adns8	463	21	%	%	NN
cord-023168-cd7adns8	463	22	by	by	IN
cord-023168-cd7adns8	463	23	age	age	NN
cord-023168-cd7adns8	463	24	30	30	CD
cord-023168-cd7adns8	463	25	years	year	NNS
cord-023168-cd7adns8	463	26	and	and	CC
cord-023168-cd7adns8	463	27	24	24	CD
cord-023168-cd7adns8	463	28	%	%	NN
cord-023168-cd7adns8	463	29	by	by	IN
cord-023168-cd7adns8	463	30	age	age	NN
cord-023168-cd7adns8	463	31	45	45	CD
cord-023168-cd7adns8	463	32	years	year	NNS
cord-023168-cd7adns8	463	33	.	.	.
cord-023168-cd7adns8	464	1	Both	both	DT
cord-023168-cd7adns8	464	2	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	464	3	and	and	CC
cord-023168-cd7adns8	464	4	haemorrhagic	haemorrhagic	JJ
cord-023168-cd7adns8	464	5	strokes	stroke	NNS
cord-023168-cd7adns8	464	6	occur	occur	VBP
cord-023168-cd7adns8	464	7	,	,	,
cord-023168-cd7adns8	464	8	although	although	IN
cord-023168-cd7adns8	464	9	the	the	DT
cord-023168-cd7adns8	464	10	former	former	JJ
cord-023168-cd7adns8	464	11	is	be	VBZ
cord-023168-cd7adns8	464	12	more	more	RBR
cord-023168-cd7adns8	464	13	common	common	JJ
cord-023168-cd7adns8	464	14	in	in	IN
cord-023168-cd7adns8	464	15	children	child	NNS
cord-023168-cd7adns8	464	16	and	and	CC
cord-023168-cd7adns8	464	17	those	those	DT
cord-023168-cd7adns8	464	18	over	over	IN
cord-023168-cd7adns8	464	19	30	30	CD
cord-023168-cd7adns8	464	20	years	year	NNS
cord-023168-cd7adns8	464	21	of	of	IN
cord-023168-cd7adns8	464	22	age	age	NN
cord-023168-cd7adns8	464	23	,	,	,
cord-023168-cd7adns8	464	24	whereas	whereas	IN
cord-023168-cd7adns8	464	25	the	the	DT
cord-023168-cd7adns8	464	26	latter	latter	NN
cord-023168-cd7adns8	464	27	is	be	VBZ
cord-023168-cd7adns8	464	28	more	more	RBR
cord-023168-cd7adns8	464	29	common	common	JJ
cord-023168-cd7adns8	464	30	between	between	IN
cord-023168-cd7adns8	464	31	the	the	DT
cord-023168-cd7adns8	464	32	ages	age	NNS
cord-023168-cd7adns8	464	33	of	of	IN
cord-023168-cd7adns8	464	34	20	20	CD
cord-023168-cd7adns8	464	35	and	and	CC
cord-023168-cd7adns8	464	36	30	30	CD
cord-023168-cd7adns8	464	37	years	year	NNS
cord-023168-cd7adns8	464	38	.	.	.
cord-023168-cd7adns8	465	1	108	108	CD
cord-023168-cd7adns8	466	1	This	this	DT
cord-023168-cd7adns8	466	2	age	age	NN
cord-023168-cd7adns8	466	3	-	-	HYPH
cord-023168-cd7adns8	466	4	specific	specific	JJ
cord-023168-cd7adns8	466	5	pattern	pattern	NN
cord-023168-cd7adns8	466	6	may	may	MD
cord-023168-cd7adns8	466	7	be	be	VB
cord-023168-cd7adns8	466	8	related	relate	VBN
cord-023168-cd7adns8	466	9	to	to	IN
cord-023168-cd7adns8	466	10	the	the	DT
cord-023168-cd7adns8	466	11	higher	high	JJR
cord-023168-cd7adns8	466	12	cerebral	cerebral	JJ
cord-023168-cd7adns8	466	13	flow	flow	NN
cord-023168-cd7adns8	466	14	rates	rate	NNS
cord-023168-cd7adns8	466	15	in	in	IN
cord-023168-cd7adns8	466	16	early	early	JJ
cord-023168-cd7adns8	466	17	childhood	childhood	NN
cord-023168-cd7adns8	466	18	.	.	.
cord-023168-cd7adns8	467	1	Although	although	IN
cord-023168-cd7adns8	467	2	the	the	DT
cord-023168-cd7adns8	467	3	prevalence	prevalence	NN
cord-023168-cd7adns8	467	4	of	of	IN
cord-023168-cd7adns8	467	5	clinically	clinically	RB
cord-023168-cd7adns8	467	6	overt	overt	JJ
cord-023168-cd7adns8	467	7	stroke	stroke	NN
cord-023168-cd7adns8	467	8	is	be	VBZ
cord-023168-cd7adns8	467	9	of	of	IN
cord-023168-cd7adns8	467	10	the	the	DT
cord-023168-cd7adns8	467	11	order	order	NN
cord-023168-cd7adns8	467	12	of	of	IN
cord-023168-cd7adns8	467	13	11	11	CD
cord-023168-cd7adns8	467	14	%	%	NN
cord-023168-cd7adns8	467	15	,	,	,
cord-023168-cd7adns8	467	16	clinically	clinically	RB
cord-023168-cd7adns8	467	17	silent	silent	JJ
cord-023168-cd7adns8	467	18	infarction	infarction	NN
cord-023168-cd7adns8	467	19	,	,	,
cord-023168-cd7adns8	467	20	detectable	detectable	JJ
cord-023168-cd7adns8	467	21	by	by	IN
cord-023168-cd7adns8	467	22	magnetic	magnetic	JJ
cord-023168-cd7adns8	467	23	resonance	resonance	NN
cord-023168-cd7adns8	467	24	scans	scan	NNS
cord-023168-cd7adns8	467	25	,	,	,
cord-023168-cd7adns8	467	26	affect	affect	VBP
cord-023168-cd7adns8	467	27	nearly	nearly	RB
cord-023168-cd7adns8	467	28	double	double	PDT
cord-023168-cd7adns8	467	29	this	this	DT
cord-023168-cd7adns8	467	30	number	number	NN
cord-023168-cd7adns8	467	31	by	by	IN
cord-023168-cd7adns8	467	32	the	the	DT
cord-023168-cd7adns8	467	33	age	age	NN
cord-023168-cd7adns8	467	34	of	of	IN
cord-023168-cd7adns8	467	35	20	20	CD
cord-023168-cd7adns8	467	36	.	.	.
cord-023168-cd7adns8	468	1	Silent	silent	JJ
cord-023168-cd7adns8	468	2	infarcts	infarct	NNS
cord-023168-cd7adns8	468	3	are	be	VBP
cord-023168-cd7adns8	468	4	associated	associate	VBN
cord-023168-cd7adns8	468	5	with	with	IN
cord-023168-cd7adns8	468	6	cognitive	cognitive	JJ
cord-023168-cd7adns8	468	7	impairment	impairment	NN
cord-023168-cd7adns8	468	8	and	and	CC
cord-023168-cd7adns8	468	9	the	the	DT
cord-023168-cd7adns8	468	10	majority	majority	NN
cord-023168-cd7adns8	468	11	of	of	IN
cord-023168-cd7adns8	468	12	these	these	DT
cord-023168-cd7adns8	468	13	children	child	NNS
cord-023168-cd7adns8	468	14	require	require	VBP
cord-023168-cd7adns8	468	15	lifelong	lifelong	JJ
cord-023168-cd7adns8	468	16	specialist	specialist	NN
cord-023168-cd7adns8	468	17	care	care	NN
cord-023168-cd7adns8	468	18	.	.	.
cord-023168-cd7adns8	469	1	104	104	CD
cord-023168-cd7adns8	469	2	Cerebral	cerebral	JJ
cord-023168-cd7adns8	469	3	thrombosis	thrombosis	NN
cord-023168-cd7adns8	469	4	,	,	,
cord-023168-cd7adns8	469	5	which	which	WDT
cord-023168-cd7adns8	469	6	accounts	account	VBZ
cord-023168-cd7adns8	469	7	for	for	IN
cord-023168-cd7adns8	469	8	70	70	CD
cord-023168-cd7adns8	469	9	-	-	SYM
cord-023168-cd7adns8	469	10	80	80	CD
cord-023168-cd7adns8	469	11	%	%	NN
cord-023168-cd7adns8	469	12	of	of	IN
cord-023168-cd7adns8	469	13	all	all	DT
cord-023168-cd7adns8	469	14	strokes	stroke	NNS
cord-023168-cd7adns8	469	15	in	in	IN
cord-023168-cd7adns8	469	16	SCD	SCD	NNP
cord-023168-cd7adns8	469	17	,	,	,
cord-023168-cd7adns8	469	18	results	result	NNS
cord-023168-cd7adns8	469	19	from	from	IN
cord-023168-cd7adns8	469	20	large	large	JJ
cord-023168-cd7adns8	469	21	-	-	HYPH
cord-023168-cd7adns8	469	22	vessel	vessel	NN
cord-023168-cd7adns8	469	23	occlusion	occlusion	NN
cord-023168-cd7adns8	469	24	whereas	whereas	IN
cord-023168-cd7adns8	469	25	silent	silent	JJ
cord-023168-cd7adns8	469	26	infarcts	infarct	NNS
cord-023168-cd7adns8	469	27	are	be	VBP
cord-023168-cd7adns8	469	28	the	the	DT
cord-023168-cd7adns8	469	29	result	result	NN
cord-023168-cd7adns8	469	30	of	of	IN
cord-023168-cd7adns8	469	31	microvascular	microvascular	JJ
cord-023168-cd7adns8	469	32	occlusion	occlusion	NN
cord-023168-cd7adns8	469	33	or	or	CC
cord-023168-cd7adns8	469	34	thrombosis	thrombosis	NN
cord-023168-cd7adns8	469	35	or	or	CC
cord-023168-cd7adns8	469	36	hypoxia	hypoxia	NN
cord-023168-cd7adns8	469	37	secondary	secondary	JJ
cord-023168-cd7adns8	469	38	to	to	IN
cord-023168-cd7adns8	469	39	large	large	JJ
cord-023168-cd7adns8	469	40	-	-	HYPH
cord-023168-cd7adns8	469	41	vessel	vessel	NN
cord-023168-cd7adns8	469	42	disease	disease	NN
cord-023168-cd7adns8	469	43	.	.	.
cord-023168-cd7adns8	470	1	In	in	IN
cord-023168-cd7adns8	470	2	a	a	DT
cord-023168-cd7adns8	470	3	third	third	NN
cord-023168-cd7adns8	470	4	of	of	IN
cord-023168-cd7adns8	470	5	SCD	SCD	NNP
cord-023168-cd7adns8	470	6	patients	patient	NNS
cord-023168-cd7adns8	470	7	,	,	,
cord-023168-cd7adns8	470	8	major	major	JJ
cord-023168-cd7adns8	470	9	-	-	HYPH
cord-023168-cd7adns8	470	10	vessel	vessel	NN
cord-023168-cd7adns8	470	11	stenosis	stenosis	NN
cord-023168-cd7adns8	470	12	is	be	VBZ
cord-023168-cd7adns8	470	13	accompanied	accompany	VBN
cord-023168-cd7adns8	470	14	by	by	IN
cord-023168-cd7adns8	470	15	collateral	collateral	JJ
cord-023168-cd7adns8	470	16	vessels	vessel	NNS
cord-023168-cd7adns8	470	17	that	that	WDT
cord-023168-cd7adns8	470	18	appear	appear	VBP
cord-023168-cd7adns8	470	19	as	as	IN
cord-023168-cd7adns8	470	20	'	'	``
cord-023168-cd7adns8	470	21	puffs	puff	NNS
cord-023168-cd7adns8	470	22	of	of	IN
cord-023168-cd7adns8	470	23	smoke	smoke	NN
cord-023168-cd7adns8	470	24	'	'	''
cord-023168-cd7adns8	470	25	(	(	-LRB-
cord-023168-cd7adns8	470	26	moyamoya	moyamoya	NNP
cord-023168-cd7adns8	470	27	)	)	-RRB-
cord-023168-cd7adns8	470	28	on	on	IN
cord-023168-cd7adns8	470	29	angiography	angiography	NN
cord-023168-cd7adns8	470	30	.	.	.
cord-023168-cd7adns8	471	1	Risk	risk	NN
cord-023168-cd7adns8	471	2	factors	factor	NNS
cord-023168-cd7adns8	471	3	for	for	IN
cord-023168-cd7adns8	471	4	ischaemic	ischaemic	JJ
cord-023168-cd7adns8	471	5	strokes	stroke	NNS
cord-023168-cd7adns8	471	6	in	in	IN
cord-023168-cd7adns8	471	7	SCD	SCD	NNP
cord-023168-cd7adns8	471	8	include	include	VBP
cord-023168-cd7adns8	471	9	increased	increase	VBN
cord-023168-cd7adns8	471	10	cerebral	cerebral	JJ
cord-023168-cd7adns8	471	11	blood	blood	NN
cord-023168-cd7adns8	471	12	flow	flow	NN
cord-023168-cd7adns8	471	13	velocity	velocity	NN
cord-023168-cd7adns8	471	14	,	,	,
cord-023168-cd7adns8	471	15	previous	previous	JJ
cord-023168-cd7adns8	471	16	silent	silent	JJ
cord-023168-cd7adns8	471	17	infarcts	infarct	NNS
cord-023168-cd7adns8	471	18	,	,	,
cord-023168-cd7adns8	471	19	nocturnal	nocturnal	JJ
cord-023168-cd7adns8	471	20	hypoxaemia	hypoxaemia	NN
cord-023168-cd7adns8	471	21	,	,	,
cord-023168-cd7adns8	471	22	severe	severe	JJ
cord-023168-cd7adns8	471	23	anaemia	anaemia	NN
cord-023168-cd7adns8	471	24	,	,	,
cord-023168-cd7adns8	471	25	acute	acute	JJ
cord-023168-cd7adns8	471	26	chest	chest	NN
cord-023168-cd7adns8	471	27	syndrome	syndrome	NN
cord-023168-cd7adns8	471	28	and	and	CC
cord-023168-cd7adns8	471	29	elevated	elevated	JJ
cord-023168-cd7adns8	471	30	systolic	systolic	JJ
cord-023168-cd7adns8	471	31	blood	blood	NN
cord-023168-cd7adns8	471	32	pressure	pressure	NN
cord-023168-cd7adns8	471	33	.	.	.
cord-023168-cd7adns8	472	1	An	an	DT
cord-023168-cd7adns8	472	2	elevated	elevated	JJ
cord-023168-cd7adns8	472	3	leukocyte	leukocyte	NN
cord-023168-cd7adns8	472	4	count	count	NN
cord-023168-cd7adns8	472	5	is	be	VBZ
cord-023168-cd7adns8	472	6	a	a	DT
cord-023168-cd7adns8	472	7	risk	risk	NN
cord-023168-cd7adns8	472	8	factor	factor	NN
cord-023168-cd7adns8	472	9	for	for	IN
cord-023168-cd7adns8	472	10	haemorrhagic	haemorrhagic	JJ
cord-023168-cd7adns8	472	11	stroke	stroke	NN
cord-023168-cd7adns8	472	12	.	.	.
cord-023168-cd7adns8	473	1	[	[	-LRB-
cord-023168-cd7adns8	473	2	105	105	CD
cord-023168-cd7adns8	473	3	]	]	-RRB-
cord-023168-cd7adns8	473	4	[	[	-LRB-
cord-023168-cd7adns8	473	5	106	106	CD
cord-023168-cd7adns8	473	6	]	]	-RRB-
cord-023168-cd7adns8	473	7	[	[	-LRB-
cord-023168-cd7adns8	473	8	107	107	CD
cord-023168-cd7adns8	473	9	]	]	-RRB-
cord-023168-cd7adns8	474	1	[	[	-LRB-
cord-023168-cd7adns8	474	2	108	108	CD
cord-023168-cd7adns8	474	3	]	]	-RRB-
cord-023168-cd7adns8	474	4	DIAGNOSIS	DIAGNOSIS	NNP
cord-023168-cd7adns8	474	5	Often	often	RB
cord-023168-cd7adns8	474	6	the	the	DT
cord-023168-cd7adns8	474	7	family	family	NN
cord-023168-cd7adns8	474	8	history	history	NN
cord-023168-cd7adns8	474	9	and	and	CC
cord-023168-cd7adns8	474	10	clinical	clinical	JJ
cord-023168-cd7adns8	474	11	findings	finding	NNS
cord-023168-cd7adns8	474	12	clearly	clearly	RB
cord-023168-cd7adns8	474	13	point	point	VBP
cord-023168-cd7adns8	474	14	towards	towards	IN
cord-023168-cd7adns8	474	15	a	a	DT
cord-023168-cd7adns8	474	16	diagnosis	diagnosis	NN
cord-023168-cd7adns8	474	17	of	of	IN
cord-023168-cd7adns8	474	18	SCD	SCD	NNP
cord-023168-cd7adns8	474	19	and	and	CC
cord-023168-cd7adns8	474	20	during	during	IN
cord-023168-cd7adns8	474	21	an	an	DT
cord-023168-cd7adns8	474	22	acute	acute	JJ
cord-023168-cd7adns8	474	23	crisis	crisis	NN
cord-023168-cd7adns8	474	24	,	,	,
cord-023168-cd7adns8	474	25	abundant	abundant	JJ
cord-023168-cd7adns8	474	26	sickled	sickled	JJ
cord-023168-cd7adns8	474	27	red	red	JJ
cord-023168-cd7adns8	474	28	cells	cell	NNS
cord-023168-cd7adns8	474	29	can	can	MD
cord-023168-cd7adns8	474	30	be	be	VB
cord-023168-cd7adns8	474	31	seen	see	VBN
cord-023168-cd7adns8	474	32	on	on	IN
cord-023168-cd7adns8	474	33	a	a	DT
cord-023168-cd7adns8	474	34	blood	blood	NN
cord-023168-cd7adns8	474	35	film	film	NN
cord-023168-cd7adns8	474	36	.	.	.
cord-023168-cd7adns8	475	1	White	white	JJ
cord-023168-cd7adns8	475	2	cell	cell	NN
cord-023168-cd7adns8	475	3	counts	count	NNS
cord-023168-cd7adns8	475	4	are	be	VBP
cord-023168-cd7adns8	475	5	higher	high	JJR
cord-023168-cd7adns8	475	6	than	than	IN
cord-023168-cd7adns8	475	7	normal	normal	JJ
cord-023168-cd7adns8	475	8	in	in	IN
cord-023168-cd7adns8	475	9	SCD	SCD	NNP
cord-023168-cd7adns8	475	10	disease	disease	NN
cord-023168-cd7adns8	475	11	,	,	,
cord-023168-cd7adns8	475	12	particularly	particularly	RB
cord-023168-cd7adns8	475	13	in	in	IN
cord-023168-cd7adns8	475	14	patients	patient	NNS
cord-023168-cd7adns8	475	15	under	under	IN
cord-023168-cd7adns8	475	16	age	age	NN
cord-023168-cd7adns8	475	17	10	10	CD
cord-023168-cd7adns8	475	18	years	year	NNS
cord-023168-cd7adns8	475	19	.	.	.
cord-023168-cd7adns8	476	1	The	the	DT
cord-023168-cd7adns8	476	2	presence	presence	NN
cord-023168-cd7adns8	476	3	of	of	IN
cord-023168-cd7adns8	476	4	sickle	sickle	NN
cord-023168-cd7adns8	476	5	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	476	6	in	in	IN
cord-023168-cd7adns8	476	7	different	different	JJ
cord-023168-cd7adns8	476	8	sickle	sickle	NN
cord-023168-cd7adns8	476	9	syndromes	syndrome	NNS
cord-023168-cd7adns8	476	10	(	(	-LRB-
cord-023168-cd7adns8	476	11	e.g.	e.g.	RB
cord-023168-cd7adns8	476	12	HbAS	HbAS	NNP
cord-023168-cd7adns8	476	13	,	,	,
cord-023168-cd7adns8	476	14	HbSS	HbSS	NNP
cord-023168-cd7adns8	476	15	,	,	,
cord-023168-cd7adns8	476	16	HbSC	HbSC	NNP
cord-023168-cd7adns8	476	17	)	)	-RRB-
cord-023168-cd7adns8	477	1	(	(	-LRB-
cord-023168-cd7adns8	477	2	Table	table	NN
cord-023168-cd7adns8	477	3	 	 	_SP
cord-023168-cd7adns8	477	4	65	65	CD
cord-023168-cd7adns8	477	5	.5	.5	NFP
cord-023168-cd7adns8	477	6	)	)	-RRB-
cord-023168-cd7adns8	477	7	can	can	MD
cord-023168-cd7adns8	477	8	be	be	VB
cord-023168-cd7adns8	477	9	confirmed	confirm	VBN
cord-023168-cd7adns8	477	10	by	by	IN
cord-023168-cd7adns8	477	11	a	a	DT
cord-023168-cd7adns8	477	12	simple	simple	JJ
cord-023168-cd7adns8	477	13	sickle	sickle	NN
cord-023168-cd7adns8	477	14	slide	slide	NN
cord-023168-cd7adns8	477	15	or	or	CC
cord-023168-cd7adns8	477	16	solubility	solubility	NN
cord-023168-cd7adns8	477	17	test	test	NN
cord-023168-cd7adns8	477	18	.	.	.
cord-023168-cd7adns8	478	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	478	2	electrophoresis	electrophoresis	NN
cord-023168-cd7adns8	478	3	will	will	MD
cord-023168-cd7adns8	478	4	distinguish	distinguish	VB
cord-023168-cd7adns8	478	5	between	between	IN
cord-023168-cd7adns8	478	6	many	many	JJ
cord-023168-cd7adns8	478	7	of	of	IN
cord-023168-cd7adns8	478	8	these	these	DT
cord-023168-cd7adns8	478	9	variants	variant	NNS
cord-023168-cd7adns8	478	10	but	but	CC
cord-023168-cd7adns8	478	11	high	high	JJ
cord-023168-cd7adns8	478	12	-	-	HYPH
cord-023168-cd7adns8	478	13	performance	performance	NN
cord-023168-cd7adns8	478	14	liquid	liquid	NN
cord-023168-cd7adns8	478	15	chromatography	chromatography	NN
cord-023168-cd7adns8	478	16	and	and	CC
cord-023168-cd7adns8	478	17	iso	iso	NN
cord-023168-cd7adns8	478	18	-	-	HYPH
cord-023168-cd7adns8	478	19	electric	electric	JJ
cord-023168-cd7adns8	478	20	focusing	focusing	NN
cord-023168-cd7adns8	478	21	are	be	VBP
cord-023168-cd7adns8	478	22	preferred	prefer	VBN
cord-023168-cd7adns8	478	23	for	for	IN
cord-023168-cd7adns8	478	24	a	a	DT
cord-023168-cd7adns8	478	25	definitive	definitive	JJ
cord-023168-cd7adns8	478	26	diagnosis	diagnosis	NN
cord-023168-cd7adns8	478	27	.	.	.
cord-023168-cd7adns8	478	28	 	 	_SP
cord-023168-cd7adns8	479	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	479	2	mass	mass	NN
cord-023168-cd7adns8	479	3	spectrometry	spectrometry	NN
cord-023168-cd7adns8	479	4	and	and	CC
cord-023168-cd7adns8	479	5	DNA	dna	NN
cord-023168-cd7adns8	479	6	analysis	analysis	NN
cord-023168-cd7adns8	479	7	are	be	VBP
cord-023168-cd7adns8	479	8	being	be	VBG
cord-023168-cd7adns8	479	9	increasingly	increasingly	RB
cord-023168-cd7adns8	479	10	used	use	VBN
cord-023168-cd7adns8	479	11	.	.	.
cord-023168-cd7adns8	480	1	Antenatal	antenatal	JJ
cord-023168-cd7adns8	480	2	screening	screening	NN
cord-023168-cd7adns8	480	3	is	be	VBZ
cord-023168-cd7adns8	480	4	available	available	JJ
cord-023168-cd7adns8	480	5	to	to	IN
cord-023168-cd7adns8	480	6	women	woman	NNS
cord-023168-cd7adns8	480	7	in	in	IN
cord-023168-cd7adns8	480	8	some	some	DT
cord-023168-cd7adns8	480	9	countries	country	NNS
cord-023168-cd7adns8	480	10	to	to	TO
cord-023168-cd7adns8	480	11	help	help	VB
cord-023168-cd7adns8	480	12	to	to	TO
cord-023168-cd7adns8	480	13	identify	identify	VB
cord-023168-cd7adns8	480	14	couples	couple	NNS
cord-023168-cd7adns8	480	15	who	who	WP
cord-023168-cd7adns8	480	16	are	be	VBP
cord-023168-cd7adns8	480	17	at	at	IN
cord-023168-cd7adns8	480	18	risk	risk	NN
cord-023168-cd7adns8	480	19	of	of	IN
cord-023168-cd7adns8	480	20	having	have	VBG
cord-023168-cd7adns8	480	21	a	a	DT
cord-023168-cd7adns8	480	22	baby	baby	NN
cord-023168-cd7adns8	480	23	with	with	IN
cord-023168-cd7adns8	480	24	SCD	SCD	NNP
cord-023168-cd7adns8	480	25	.	.	.
cord-023168-cd7adns8	481	1	Community	community	NN
cord-023168-cd7adns8	481	2	acceptance	acceptance	NN
cord-023168-cd7adns8	481	3	of	of	IN
cord-023168-cd7adns8	481	4	reproductive	reproductive	JJ
cord-023168-cd7adns8	481	5	genetic	genetic	JJ
cord-023168-cd7adns8	481	6	services	service	NNS
cord-023168-cd7adns8	481	7	however	however	RB
cord-023168-cd7adns8	481	8	depends	depend	VBZ
cord-023168-cd7adns8	481	9	on	on	IN
cord-023168-cd7adns8	481	10	the	the	DT
cord-023168-cd7adns8	481	11	effectiveness	effectiveness	NN
cord-023168-cd7adns8	481	12	of	of	IN
cord-023168-cd7adns8	481	13	education	education	NN
cord-023168-cd7adns8	481	14	and	and	CC
cord-023168-cd7adns8	481	15	counselling	counselling	NN
cord-023168-cd7adns8	481	16	.	.	.
cord-023168-cd7adns8	482	1	The	the	DT
cord-023168-cd7adns8	482	2	use	use	NN
cord-023168-cd7adns8	482	3	of	of	IN
cord-023168-cd7adns8	482	4	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	482	5	penicillin	penicillin	NN
cord-023168-cd7adns8	482	6	and	and	CC
cord-023168-cd7adns8	482	7	the	the	DT
cord-023168-cd7adns8	482	8	provision	provision	NN
cord-023168-cd7adns8	482	9	of	of	IN
cord-023168-cd7adns8	482	10	comprehensive	comprehensive	JJ
cord-023168-cd7adns8	482	11	medical	medical	JJ
cord-023168-cd7adns8	482	12	care	care	NN
cord-023168-cd7adns8	482	13	during	during	IN
cord-023168-cd7adns8	482	14	the	the	DT
cord-023168-cd7adns8	482	15	first	first	JJ
cord-023168-cd7adns8	482	16	5	5	CD
cord-023168-cd7adns8	482	17	years	year	NNS
cord-023168-cd7adns8	482	18	of	of	IN
cord-023168-cd7adns8	482	19	life	life	NN
cord-023168-cd7adns8	482	20	have	have	VBP
cord-023168-cd7adns8	482	21	reduced	reduce	VBN
cord-023168-cd7adns8	482	22	mortality	mortality	NN
cord-023168-cd7adns8	482	23	related	relate	VBN
cord-023168-cd7adns8	482	24	to	to	IN
cord-023168-cd7adns8	482	25	SCD	SCD	NNP
cord-023168-cd7adns8	482	26	from	from	IN
cord-023168-cd7adns8	482	27	25	25	CD
cord-023168-cd7adns8	482	28	%	%	NN
cord-023168-cd7adns8	482	29	to	to	IN
cord-023168-cd7adns8	482	30	less	less	JJR
cord-023168-cd7adns8	482	31	than	than	IN
cord-023168-cd7adns8	482	32	3	3	CD
cord-023168-cd7adns8	482	33	%	%	NN
cord-023168-cd7adns8	482	34	.	.	.
cord-023168-cd7adns8	483	1	109	109	CD
cord-023168-cd7adns8	483	2	MANAGEMENT	management	NN
cord-023168-cd7adns8	483	3	(	(	-LRB-
cord-023168-cd7adns8	483	4	Box	Box	NNP
cord-023168-cd7adns8	483	5	65.10	65.10	CD
cord-023168-cd7adns8	483	6	)	)	-RRB-
cord-023168-cd7adns8	484	1	Individuals	individual	NNS
cord-023168-cd7adns8	484	2	with	with	IN
cord-023168-cd7adns8	484	3	SCD	SCD	NNP
cord-023168-cd7adns8	484	4	are	be	VBP
cord-023168-cd7adns8	484	5	best	well	RBS
cord-023168-cd7adns8	484	6	managed	manage	VBN
cord-023168-cd7adns8	484	7	by	by	IN
cord-023168-cd7adns8	484	8	a	a	DT
cord-023168-cd7adns8	484	9	multidisciplinary	multidisciplinary	JJ
cord-023168-cd7adns8	484	10	team	team	NN
cord-023168-cd7adns8	484	11	as	as	IN
cord-023168-cd7adns8	484	12	they	-PRON-	PRP
cord-023168-cd7adns8	484	13	may	may	MD
cord-023168-cd7adns8	484	14	require	require	VB
cord-023168-cd7adns8	484	15	a	a	DT
cord-023168-cd7adns8	484	16	variety	variety	NN
cord-023168-cd7adns8	484	17	of	of	IN
cord-023168-cd7adns8	484	18	specialist	specialist	NN
cord-023168-cd7adns8	484	19	inputs	input	NNS
cord-023168-cd7adns8	484	20	including	include	VBG
cord-023168-cd7adns8	484	21	haematology	haematology	NNP
cord-023168-cd7adns8	484	22	,	,	,
cord-023168-cd7adns8	484	23	ophthalmology	ophthalmology	NN
cord-023168-cd7adns8	484	24	,	,	,
cord-023168-cd7adns8	484	25	nephrology	nephrology	NN
cord-023168-cd7adns8	484	26	,	,	,
cord-023168-cd7adns8	484	27	obstetrics	obstetric	NNS
cord-023168-cd7adns8	484	28	,	,	,
cord-023168-cd7adns8	484	29	orthopaedics	orthopaedic	NNS
cord-023168-cd7adns8	484	30	and	and	CC
cord-023168-cd7adns8	484	31	physiotherapy	physiotherapy	NN
cord-023168-cd7adns8	484	32	.	.	.
cord-023168-cd7adns8	485	1	The	the	DT
cord-023168-cd7adns8	485	2	cornerstones	cornerstone	NNS
cord-023168-cd7adns8	485	3	of	of	IN
cord-023168-cd7adns8	485	4	SCD	SCD	NNP
cord-023168-cd7adns8	485	5	therapy	therapy	NN
cord-023168-cd7adns8	485	6	are	be	VBP
cord-023168-cd7adns8	485	7	disease	disease	NN
cord-023168-cd7adns8	485	8	modification	modification	NN
cord-023168-cd7adns8	485	9	and	and	CC
cord-023168-cd7adns8	485	10	prompt	prompt	JJ
cord-023168-cd7adns8	485	11	and	and	CC
cord-023168-cd7adns8	485	12	effective	effective	JJ
cord-023168-cd7adns8	485	13	management	management	NN
cord-023168-cd7adns8	485	14	of	of	IN
cord-023168-cd7adns8	485	15	crises	crisis	NNS
cord-023168-cd7adns8	485	16	.	.	.
cord-023168-cd7adns8	486	1	Severe	severe	JJ
cord-023168-cd7adns8	486	2	pain	pain	NN
cord-023168-cd7adns8	486	3	crises	crisis	NNS
cord-023168-cd7adns8	486	4	generally	generally	RB
cord-023168-cd7adns8	486	5	require	require	VBP
cord-023168-cd7adns8	486	6	intravenous	intravenous	JJ
cord-023168-cd7adns8	486	7	fluids	fluid	NNS
cord-023168-cd7adns8	486	8	and	and	CC
cord-023168-cd7adns8	486	9	adequate	adequate	JJ
cord-023168-cd7adns8	486	10	,	,	,
cord-023168-cd7adns8	486	11	often	often	RB
cord-023168-cd7adns8	486	12	opiate	opiate	NN
cord-023168-cd7adns8	486	13	,	,	,
cord-023168-cd7adns8	486	14	analgesia	analgesia	FW
cord-023168-cd7adns8	486	15	(	(	-LRB-
cord-023168-cd7adns8	486	16	Box	Box	NNP
cord-023168-cd7adns8	486	17	65.11	65.11	CD
cord-023168-cd7adns8	486	18	)	)	-RRB-
cord-023168-cd7adns8	486	19	,	,	,
cord-023168-cd7adns8	486	20	while	while	IN
cord-023168-cd7adns8	486	21	disease	disease	NN
cord-023168-cd7adns8	486	22	modification	modification	NN
cord-023168-cd7adns8	486	23	is	be	VBZ
cord-023168-cd7adns8	486	24	based	base	VBN
cord-023168-cd7adns8	486	25	on	on	IN
cord-023168-cd7adns8	486	26	interventions	intervention	NNS
cord-023168-cd7adns8	486	27	to	to	TO
cord-023168-cd7adns8	486	28	increase	increase	VB
cord-023168-cd7adns8	486	29	HbF	hbf	JJ
cord-023168-cd7adns8	486	30	levels	level	NNS
cord-023168-cd7adns8	486	31	.	.	.
cord-023168-cd7adns8	487	1	In	in	IN
cord-023168-cd7adns8	487	2	steady	steady	JJ
cord-023168-cd7adns8	487	3	state	state	NN
cord-023168-cd7adns8	487	4	it	-PRON-	PRP
cord-023168-cd7adns8	487	5	is	be	VBZ
cord-023168-cd7adns8	487	6	usual	usual	JJ
cord-023168-cd7adns8	487	7	practice	practice	NN
cord-023168-cd7adns8	487	8	to	to	TO
cord-023168-cd7adns8	487	9	give	give	VB
cord-023168-cd7adns8	487	10	sickle	sickle	NN
cord-023168-cd7adns8	487	11	cell	cell	NN
cord-023168-cd7adns8	487	12	patients	patient	NNS
cord-023168-cd7adns8	487	13	folate	folate	VBP
cord-023168-cd7adns8	487	14	supplements	supplement	NNS
cord-023168-cd7adns8	487	15	(	(	-LRB-
cord-023168-cd7adns8	487	16	1	1	CD
cord-023168-cd7adns8	487	17	-	-	SYM
cord-023168-cd7adns8	487	18	5	5	CD
cord-023168-cd7adns8	487	19	mg	mg	NNP
cord-023168-cd7adns8	487	20	/	/	SYM
cord-023168-cd7adns8	487	21	day	day	NN
cord-023168-cd7adns8	487	22	)	)	-RRB-
cord-023168-cd7adns8	487	23	because	because	IN
cord-023168-cd7adns8	487	24	their	-PRON-	PRP$
cord-023168-cd7adns8	487	25	high	high	JJ
cord-023168-cd7adns8	487	26	rates	rate	NNS
cord-023168-cd7adns8	487	27	of	of	IN
cord-023168-cd7adns8	487	28	haemopoiesis	haemopoiesis	NN
cord-023168-cd7adns8	487	29	put	put	VBD
cord-023168-cd7adns8	487	30	them	-PRON-	PRP
cord-023168-cd7adns8	487	31	at	at	IN
cord-023168-cd7adns8	487	32	risk	risk	NN
cord-023168-cd7adns8	487	33	of	of	IN
cord-023168-cd7adns8	487	34	deficiency	deficiency	NN
cord-023168-cd7adns8	487	35	.	.	.
cord-023168-cd7adns8	488	1	SCD	SCD	NNP
cord-023168-cd7adns8	488	2	is	be	VBZ
cord-023168-cd7adns8	488	3	associated	associate	VBN
cord-023168-cd7adns8	488	4	with	with	IN
cord-023168-cd7adns8	488	5	functional	functional	JJ
cord-023168-cd7adns8	488	6	asplenia	asplenia	NN
cord-023168-cd7adns8	488	7	so	so	IN
cord-023168-cd7adns8	488	8	patients	patient	NNS
cord-023168-cd7adns8	488	9	should	should	MD
cord-023168-cd7adns8	488	10	also	also	RB
cord-023168-cd7adns8	488	11	receive	receive	VB
cord-023168-cd7adns8	488	12	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	488	13	oral	oral	JJ
cord-023168-cd7adns8	488	14	penicillin	penicillin	NN
cord-023168-cd7adns8	488	15	(	(	-LRB-
cord-023168-cd7adns8	488	16	250	250	CD
cord-023168-cd7adns8	488	17	mg	mg	NNS
cord-023168-cd7adns8	488	18	twice	twice	PDT
cord-023168-cd7adns8	488	19	a	a	DT
cord-023168-cd7adns8	488	20	day	day	NN
cord-023168-cd7adns8	488	21	)	)	-RRB-
cord-023168-cd7adns8	488	22	and	and	CC
cord-023168-cd7adns8	488	23	vaccinations	vaccination	NNS
cord-023168-cd7adns8	488	24	against	against	IN
cord-023168-cd7adns8	488	25	encapsulated	encapsulate	VBN
cord-023168-cd7adns8	488	26	organisms	organism	NNS
cord-023168-cd7adns8	488	27	.	.	.
cord-023168-cd7adns8	489	1	Hydroxycarbamide	Hydroxycarbamide	NNP
cord-023168-cd7adns8	489	2	is	be	VBZ
cord-023168-cd7adns8	489	3	the	the	DT
cord-023168-cd7adns8	489	4	main	main	JJ
cord-023168-cd7adns8	489	5	agent	agent	NN
cord-023168-cd7adns8	489	6	used	use	VBD
cord-023168-cd7adns8	489	7	to	to	TO
cord-023168-cd7adns8	489	8	increase	increase	VB
cord-023168-cd7adns8	489	9	HbF	HbF	NNP
cord-023168-cd7adns8	489	10	(	(	-LRB-
cord-023168-cd7adns8	489	11	Box	Box	NNP
cord-023168-cd7adns8	489	12	65.12	65.12	CD
cord-023168-cd7adns8	489	13	)	)	-RRB-
cord-023168-cd7adns8	489	14	and	and	CC
cord-023168-cd7adns8	489	15	is	be	VBZ
cord-023168-cd7adns8	489	16	associated	associate	VBN
cord-023168-cd7adns8	489	17	with	with	IN
cord-023168-cd7adns8	489	18	significant	significant	JJ
cord-023168-cd7adns8	489	19	reductions	reduction	NNS
cord-023168-cd7adns8	489	20	in	in	IN
cord-023168-cd7adns8	489	21	acute	acute	JJ
cord-023168-cd7adns8	489	22	pain	pain	NN
cord-023168-cd7adns8	489	23	crises	crisis	NNS
cord-023168-cd7adns8	489	24	,	,	,
cord-023168-cd7adns8	489	25	hospitalization	hospitalization	NN
cord-023168-cd7adns8	489	26	rate	rate	NN
cord-023168-cd7adns8	489	27	,	,	,
cord-023168-cd7adns8	489	28	time	time	NN
cord-023168-cd7adns8	489	29	to	to	IN
cord-023168-cd7adns8	489	30	first	first	JJ
cord-023168-cd7adns8	489	31	and	and	CC
cord-023168-cd7adns8	489	32	second	second	JJ
cord-023168-cd7adns8	489	33	pain	pain	NN
cord-023168-cd7adns8	489	34	crises	crisis	NNS
cord-023168-cd7adns8	489	35	,	,	,
cord-023168-cd7adns8	489	36	episodes	episode	NNS
cord-023168-cd7adns8	489	37	of	of	IN
cord-023168-cd7adns8	489	38	acute	acute	JJ
cord-023168-cd7adns8	489	39	chest	chest	NN
cord-023168-cd7adns8	489	40	syndrome	syndrome	NN
cord-023168-cd7adns8	489	41	,	,	,
cord-023168-cd7adns8	489	42	and	and	CC
cord-023168-cd7adns8	489	43	the	the	DT
cord-023168-cd7adns8	489	44	need	need	NN
cord-023168-cd7adns8	489	45	for	for	IN
cord-023168-cd7adns8	489	46	transfusions	transfusion	NNS
cord-023168-cd7adns8	489	47	and	and	CC
cord-023168-cd7adns8	489	48	the	the	DT
cord-023168-cd7adns8	489	49	number	number	NN
cord-023168-cd7adns8	489	50	of	of	IN
cord-023168-cd7adns8	489	51	units	unit	NNS
cord-023168-cd7adns8	489	52	transfused	transfuse	VBN
cord-023168-cd7adns8	489	53	.	.	.
cord-023168-cd7adns8	490	1	110	110	CD
cord-023168-cd7adns8	490	2	Other	other	JJ
cord-023168-cd7adns8	490	3	beneficial	beneficial	JJ
cord-023168-cd7adns8	490	4	effects	effect	NNS
cord-023168-cd7adns8	490	5	of	of	IN
cord-023168-cd7adns8	490	6	hydroxycarbamide	hydroxycarbamide	NN
cord-023168-cd7adns8	490	7	,	,	,
cord-023168-cd7adns8	490	8	which	which	WDT
cord-023168-cd7adns8	490	9	are	be	VBP
cord-023168-cd7adns8	490	10	independent	independent	JJ
cord-023168-cd7adns8	490	11	of	of	IN
cord-023168-cd7adns8	490	12	the	the	DT
cord-023168-cd7adns8	490	13	increase	increase	NN
cord-023168-cd7adns8	490	14	in	in	IN
cord-023168-cd7adns8	490	15	HbF	HbF	NNP
cord-023168-cd7adns8	490	16	,	,	,
cord-023168-cd7adns8	490	17	include	include	VBP
cord-023168-cd7adns8	490	18	reduced	reduce	VBN
cord-023168-cd7adns8	490	19	neutrophil	neutrophil	NN
cord-023168-cd7adns8	490	20	count	count	NN
cord-023168-cd7adns8	490	21	,	,	,
cord-023168-cd7adns8	490	22	increased	increase	VBD
cord-023168-cd7adns8	490	23	cellular	cellular	JJ
cord-023168-cd7adns8	490	24	water	water	NN
cord-023168-cd7adns8	490	25	content	content	NN
cord-023168-cd7adns8	490	26	,	,	,
cord-023168-cd7adns8	490	27	decreased	decrease	VBD
cord-023168-cd7adns8	490	28	HbS	hbs	JJ
cord-023168-cd7adns8	490	29	concentration	concentration	NN
cord-023168-cd7adns8	490	30	,	,	,
cord-023168-cd7adns8	490	31	changing	change	VBG
cord-023168-cd7adns8	490	32	expression	expression	NN
cord-023168-cd7adns8	490	33	of	of	IN
cord-023168-cd7adns8	490	34	adhesion	adhesion	NN
cord-023168-cd7adns8	490	35	molecules	molecule	NNS
cord-023168-cd7adns8	490	36	and	and	CC
cord-023168-cd7adns8	490	37	nitric	nitric	JJ
cord-023168-cd7adns8	490	38	oxide	oxide	NN
cord-023168-cd7adns8	490	39	generation	generation	NN
cord-023168-cd7adns8	490	40	.	.	.
cord-023168-cd7adns8	491	1	111	111	CD
cord-023168-cd7adns8	492	1	Hydroxycarbamide	Hydroxycarbamide	NNP
cord-023168-cd7adns8	492	2	may	may	MD
cord-023168-cd7adns8	492	3	also	also	RB
cord-023168-cd7adns8	492	4	be	be	VB
cord-023168-cd7adns8	492	5	an	an	DT
cord-023168-cd7adns8	492	6	alternative	alternative	NN
cord-023168-cd7adns8	492	7	to	to	IN
cord-023168-cd7adns8	492	8	frequent	frequent	JJ
cord-023168-cd7adns8	492	9	blood	blood	NN
cord-023168-cd7adns8	492	10	transfusions	transfusion	NNS
cord-023168-cd7adns8	492	11	for	for	IN
cord-023168-cd7adns8	492	12	the	the	DT
cord-023168-cd7adns8	492	13	prevention	prevention	NN
cord-023168-cd7adns8	492	14	of	of	IN
cord-023168-cd7adns8	492	15	recurrent	recurrent	JJ
cord-023168-cd7adns8	492	16	stroke	stroke	NN
cord-023168-cd7adns8	492	17	in	in	IN
cord-023168-cd7adns8	492	18	children	child	NNS
cord-023168-cd7adns8	492	19	as	as	IN
cord-023168-cd7adns8	492	20	it	-PRON-	PRP
cord-023168-cd7adns8	492	21	can	can	MD
cord-023168-cd7adns8	492	22	lower	lower	VB
cord-023168-cd7adns8	492	23	transcranial	transcranial	JJ
cord-023168-cd7adns8	492	24	Doppler	Doppler	NNP
cord-023168-cd7adns8	492	25	velocities	velocity	NNS
cord-023168-cd7adns8	492	26	.	.	.
cord-023168-cd7adns8	493	1	112	112	CD
cord-023168-cd7adns8	493	2	,	,	,
cord-023168-cd7adns8	493	3	113	113	CD
cord-023168-cd7adns8	493	4	Under	under	IN
cord-023168-cd7adns8	493	5	-	-	HYPH
cord-023168-cd7adns8	493	6	use	use	NN
cord-023168-cd7adns8	493	7	of	of	IN
cord-023168-cd7adns8	493	8	this	this	DT
cord-023168-cd7adns8	493	9	cheap	cheap	JJ
cord-023168-cd7adns8	493	10	,	,	,
cord-023168-cd7adns8	493	11	effective	effective	JJ
cord-023168-cd7adns8	493	12	drug	drug	NN
cord-023168-cd7adns8	493	13	is	be	VBZ
cord-023168-cd7adns8	493	14	related	relate	VBN
cord-023168-cd7adns8	493	15	to	to	IN
cord-023168-cd7adns8	493	16	concerns	concern	NNS
cord-023168-cd7adns8	493	17	about	about	IN
cord-023168-cd7adns8	493	18	leukaemogenicity	leukaemogenicity	NN
cord-023168-cd7adns8	493	19	but	but	CC
cord-023168-cd7adns8	493	20	this	this	DT
cord-023168-cd7adns8	493	21	has	have	VBZ
cord-023168-cd7adns8	493	22	not	not	RB
cord-023168-cd7adns8	493	23	been	be	VBN
cord-023168-cd7adns8	493	24	shown	show	VBN
cord-023168-cd7adns8	493	25	to	to	TO
cord-023168-cd7adns8	493	26	be	be	VB
cord-023168-cd7adns8	493	27	a	a	DT
cord-023168-cd7adns8	493	28	problem	problem	NN
cord-023168-cd7adns8	493	29	when	when	WRB
cord-023168-cd7adns8	493	30	used	use	VBN
cord-023168-cd7adns8	493	31	for	for	IN
cord-023168-cd7adns8	493	32	a	a	DT
cord-023168-cd7adns8	493	33	non	non	JJ
cord-023168-cd7adns8	493	34	-	-	JJ
cord-023168-cd7adns8	493	35	malignant	malignant	JJ
cord-023168-cd7adns8	493	36	condition	condition	NN
cord-023168-cd7adns8	493	37	like	like	IN
cord-023168-cd7adns8	493	38	SCD	SCD	NNP
cord-023168-cd7adns8	493	39	.	.	.
cord-023168-cd7adns8	494	1	The	the	DT
cord-023168-cd7adns8	494	2	two	two	CD
cord-023168-cd7adns8	494	3	main	main	JJ
cord-023168-cd7adns8	494	4	approaches	approach	NNS
cord-023168-cd7adns8	494	5	to	to	IN
cord-023168-cd7adns8	494	6	transfusion	transfusion	NN
cord-023168-cd7adns8	494	7	74	74	CD
cord-023168-cd7adns8	494	8	in	in	IN
cord-023168-cd7adns8	494	9	SCD	SCD	NNP
cord-023168-cd7adns8	494	10	are	be	VBP
cord-023168-cd7adns8	494	11	simple	simple	JJ
cord-023168-cd7adns8	494	12	top	top	JJ
cord-023168-cd7adns8	494	13	-	-	HYPH
cord-023168-cd7adns8	494	14	up	up	RP
cord-023168-cd7adns8	494	15	transfusion	transfusion	NN
cord-023168-cd7adns8	494	16	and	and	CC
cord-023168-cd7adns8	494	17	exchange	exchange	NN
cord-023168-cd7adns8	494	18	transfusion	transfusion	NN
cord-023168-cd7adns8	494	19	.	.	.
cord-023168-cd7adns8	495	1	Target	target	VB
cord-023168-cd7adns8	495	2	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	495	3	level	level	NN
cord-023168-cd7adns8	495	4	in	in	IN
cord-023168-cd7adns8	495	5	SCD	SCD	NNP
cord-023168-cd7adns8	495	6	therapy	therapy	NN
cord-023168-cd7adns8	495	7	is	be	VBZ
cord-023168-cd7adns8	495	8	100	100	CD
cord-023168-cd7adns8	495	9	g	g	NN
cord-023168-cd7adns8	495	10	/	/	SYM
cord-023168-cd7adns8	495	11	L	L	NNP
cord-023168-cd7adns8	495	12	or	or	CC
cord-023168-cd7adns8	495	13	a	a	DT
cord-023168-cd7adns8	495	14	haematocrit	haematocrit	NN
cord-023168-cd7adns8	495	15	of	of	IN
cord-023168-cd7adns8	495	16	30	30	CD
cord-023168-cd7adns8	495	17	%	%	NN
cord-023168-cd7adns8	495	18	;	;	,
cord-023168-cd7adns8	495	19	higher	high	JJR
cord-023168-cd7adns8	495	20	target	target	NN
cord-023168-cd7adns8	495	21	levels	level	NNS
cord-023168-cd7adns8	495	22	are	be	VBP
cord-023168-cd7adns8	495	23	associated	associate	VBN
cord-023168-cd7adns8	495	24	with	with	IN
cord-023168-cd7adns8	495	25	hyperviscosity	hyperviscosity	NN
cord-023168-cd7adns8	495	26	and	and	CC
cord-023168-cd7adns8	495	27	BOX	BOX	NNP
cord-023168-cd7adns8	495	28	65.10	65.10	CD
cord-023168-cd7adns8	495	29	MANAGEMENT	management	NN
cord-023168-cd7adns8	495	30	OF	of	IN
cord-023168-cd7adns8	495	31	COMPLICATIONS	complication	NNS
cord-023168-cd7adns8	495	32	OF	of	IN
cord-023168-cd7adns8	495	33	SICKLE	sickle	NN
cord-023168-cd7adns8	495	34	CELL	cell	NN
cord-023168-cd7adns8	495	35	DISEASE	disease	NN
cord-023168-cd7adns8	496	1	•	•	NNP
cord-023168-cd7adns8	497	1	Inability	inability	NN
cord-023168-cd7adns8	497	2	to	to	TO
cord-023168-cd7adns8	497	3	maximally	maximally	RB
cord-023168-cd7adns8	497	4	concentrate	concentrate	VB
cord-023168-cd7adns8	497	5	urine	urine	NN
cord-023168-cd7adns8	497	6	(	(	-LRB-
cord-023168-cd7adns8	497	7	hyposthenuria	hyposthenuria	NNP
cord-023168-cd7adns8	497	8	)	)	-RRB-
cord-023168-cd7adns8	497	9	in	in	IN
cord-023168-cd7adns8	497	10	response	response	NN
cord-023168-cd7adns8	497	11	to	to	IN
cord-023168-cd7adns8	497	12	water	water	NN
cord-023168-cd7adns8	497	13	deprivation	deprivation	NN
cord-023168-cd7adns8	497	14	is	be	VBZ
cord-023168-cd7adns8	497	15	an	an	DT
cord-023168-cd7adns8	497	16	early	early	JJ
cord-023168-cd7adns8	497	17	finding	finding	NN
cord-023168-cd7adns8	498	1	•	•	NNP
cord-023168-cd7adns8	499	1	Renal	renal	JJ
cord-023168-cd7adns8	499	2	tubular	tubular	JJ
cord-023168-cd7adns8	499	3	acidosis	acidosis	NN
cord-023168-cd7adns8	500	1	•	•	NNP
cord-023168-cd7adns8	501	1	Increased	increase	VBN
cord-023168-cd7adns8	501	2	urinary	urinary	JJ
cord-023168-cd7adns8	501	3	tract	tract	NN
cord-023168-cd7adns8	501	4	infections	infection	NNS
cord-023168-cd7adns8	502	1	•	•	NNP
cord-023168-cd7adns8	503	1	Glomerular	glomerular	JJ
cord-023168-cd7adns8	503	2	hyperfiltration	hyperfiltration	NN
cord-023168-cd7adns8	503	3	,	,	,
cord-023168-cd7adns8	503	4	increased	increase	VBN
cord-023168-cd7adns8	503	5	creatinine	creatinine	NN
cord-023168-cd7adns8	503	6	secretion	secretion	NN
cord-023168-cd7adns8	503	7	,	,	,
cord-023168-cd7adns8	503	8	and	and	CC
cord-023168-cd7adns8	503	9	a	a	DT
cord-023168-cd7adns8	503	10	very	very	RB
cord-023168-cd7adns8	503	11	low	low	JJ
cord-023168-cd7adns8	503	12	serum	serum	NN
cord-023168-cd7adns8	503	13	creatinine	creatinine	NN
cord-023168-cd7adns8	503	14	are	be	VBP
cord-023168-cd7adns8	503	15	characteristic	characteristic	JJ
cord-023168-cd7adns8	503	16	of	of	IN
cord-023168-cd7adns8	503	17	young	young	JJ
cord-023168-cd7adns8	503	18	patients	patient	NNS
cord-023168-cd7adns8	503	19	with	with	IN
cord-023168-cd7adns8	503	20	sickle	sickle	NN
cord-023168-cd7adns8	503	21	cell	cell	NN
cord-023168-cd7adns8	503	22	anaemia	anaemia	NN
cord-023168-cd7adns8	503	23	,	,	,
cord-023168-cd7adns8	503	24	so	so	RB
cord-023168-cd7adns8	503	25	renal	renal	JJ
cord-023168-cd7adns8	503	26	dysfunction	dysfunction	NN
cord-023168-cd7adns8	503	27	can	can	MD
cord-023168-cd7adns8	503	28	be	be	VB
cord-023168-cd7adns8	503	29	present	present	JJ
cord-023168-cd7adns8	503	30	even	even	RB
cord-023168-cd7adns8	503	31	with	with	IN
cord-023168-cd7adns8	503	32	normal	normal	JJ
cord-023168-cd7adns8	503	33	serum	serum	NN
cord-023168-cd7adns8	503	34	creatinine	creatinine	NN
cord-023168-cd7adns8	503	35	values	value	NNS
cord-023168-cd7adns8	504	1	•	•	NNP
cord-023168-cd7adns8	505	1	Microalbuminuria	Microalbuminuria	NNP
cord-023168-cd7adns8	505	2	is	be	VBZ
cord-023168-cd7adns8	505	3	common	common	JJ
cord-023168-cd7adns8	505	4	in	in	IN
cord-023168-cd7adns8	505	5	childhood	childhood	NN
cord-023168-cd7adns8	505	6	and	and	CC
cord-023168-cd7adns8	505	7	up	up	IN
cord-023168-cd7adns8	505	8	to	to	TO
cord-023168-cd7adns8	505	9	20	20	CD
cord-023168-cd7adns8	505	10	%	%	NN
cord-023168-cd7adns8	505	11	of	of	IN
cord-023168-cd7adns8	505	12	adults	adult	NNS
cord-023168-cd7adns8	505	13	develop	develop	VBP
cord-023168-cd7adns8	505	14	nephrotic	nephrotic	JJ
cord-023168-cd7adns8	505	15	-	-	HYPH
cord-023168-cd7adns8	505	16	range	range	NN
cord-023168-cd7adns8	505	17	protein	protein	NN
cord-023168-cd7adns8	505	18	loss	loss	NN
cord-023168-cd7adns8	506	1	•	•	NNP
cord-023168-cd7adns8	507	1	Gross	gross	JJ
cord-023168-cd7adns8	507	2	haematuria	haematuria	NNS
cord-023168-cd7adns8	507	3	can	can	MD
cord-023168-cd7adns8	507	4	develop	develop	VB
cord-023168-cd7adns8	507	5	due	due	IN
cord-023168-cd7adns8	507	6	to	to	IN
cord-023168-cd7adns8	507	7	microthrombin	microthrombin	NNP
cord-023168-cd7adns8	507	8	in	in	IN
cord-023168-cd7adns8	507	9	renal	renal	JJ
cord-023168-cd7adns8	507	10	vessels	vessel	NNS
cord-023168-cd7adns8	507	11	,	,	,
cord-023168-cd7adns8	507	12	renal	renal	JJ
cord-023168-cd7adns8	507	13	medullary	medullary	JJ
cord-023168-cd7adns8	507	14	carcinoma	carcinoma	NN
cord-023168-cd7adns8	507	15	,	,	,
cord-023168-cd7adns8	507	16	and	and	CC
cord-023168-cd7adns8	507	17	nocturnal	nocturnal	JJ
cord-023168-cd7adns8	507	18	enuresis	enuresis	NN
cord-023168-cd7adns8	508	1	•	•	NNP
cord-023168-cd7adns8	509	1	Treatment	treatment	NN
cord-023168-cd7adns8	509	2	is	be	VBZ
cord-023168-cd7adns8	509	3	based	base	VBN
cord-023168-cd7adns8	509	4	on	on	IN
cord-023168-cd7adns8	509	5	the	the	DT
cord-023168-cd7adns8	509	6	early	early	JJ
cord-023168-cd7adns8	509	7	use	use	NN
cord-023168-cd7adns8	509	8	of	of	IN
cord-023168-cd7adns8	509	9	hydroxycarbamide	hydroxycarbamide	NN
cord-023168-cd7adns8	509	10	and	and	CC
cord-023168-cd7adns8	509	11	angiotensin	angiotensin	NN
cord-023168-cd7adns8	509	12	-	-	HYPH
cord-023168-cd7adns8	509	13	converting	convert	VBG
cord-023168-cd7adns8	509	14	enzyme	enzyme	NN
cord-023168-cd7adns8	509	15	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	509	16	in	in	IN
cord-023168-cd7adns8	509	17	children	child	NNS
cord-023168-cd7adns8	509	18	with	with	IN
cord-023168-cd7adns8	509	19	clinically	clinically	RB
cord-023168-cd7adns8	509	20	significant	significant	JJ
cord-023168-cd7adns8	509	21	albuminuria	albuminuria	NNS
cord-023168-cd7adns8	509	22	.	.	.
cord-023168-cd7adns8	510	1	•	•	NNP
cord-023168-cd7adns8	511	1	Noted	note	VBN
cord-023168-cd7adns8	511	2	in	in	IN
cord-023168-cd7adns8	511	3	up	up	IN
cord-023168-cd7adns8	511	4	to	to	TO
cord-023168-cd7adns8	511	5	60	60	CD
cord-023168-cd7adns8	511	6	%	%	NN
cord-023168-cd7adns8	511	7	of	of	IN
cord-023168-cd7adns8	511	8	SCD	SCD	NNP
cord-023168-cd7adns8	511	9	cases	case	NNS
cord-023168-cd7adns8	512	1	•	•	NNP
cord-023168-cd7adns8	513	1	No	no	DT
cord-023168-cd7adns8	513	2	relationship	relationship	NN
cord-023168-cd7adns8	513	3	to	to	IN
cord-023168-cd7adns8	513	4	acute	acute	JJ
cord-023168-cd7adns8	513	5	chest	chest	NN
cord-023168-cd7adns8	513	6	syndrome	syndrome	NN
cord-023168-cd7adns8	513	7	(	(	-LRB-
cord-023168-cd7adns8	513	8	different	different	JJ
cord-023168-cd7adns8	513	9	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	513	10	)	)	-RRB-
cord-023168-cd7adns8	514	1	•	•	NNP
cord-023168-cd7adns8	515	1	Mortality	mortality	NN
cord-023168-cd7adns8	515	2	risk	risk	NN
cord-023168-cd7adns8	515	3	with	with	IN
cord-023168-cd7adns8	515	4	even	even	RB
cord-023168-cd7adns8	515	5	mild	mild	JJ
cord-023168-cd7adns8	515	6	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	515	7	hypertension	hypertension	NN
cord-023168-cd7adns8	515	8	is	be	VBZ
cord-023168-cd7adns8	515	9	high	high	JJ
cord-023168-cd7adns8	516	1	•	•	NNP
cord-023168-cd7adns8	517	1	Regular	regular	JJ
cord-023168-cd7adns8	517	2	blood	blood	NN
cord-023168-cd7adns8	517	3	transfusions	transfusion	NNS
cord-023168-cd7adns8	517	4	and	and	CC
cord-023168-cd7adns8	517	5	long	long	JJ
cord-023168-cd7adns8	517	6	-	-	HYPH
cord-023168-cd7adns8	517	7	term	term	NN
cord-023168-cd7adns8	517	8	anticoagulation	anticoagulation	NN
cord-023168-cd7adns8	517	9	have	have	VBP
cord-023168-cd7adns8	517	10	been	be	VBN
cord-023168-cd7adns8	517	11	tried	try	VBN
cord-023168-cd7adns8	518	1	•	•	NNP
cord-023168-cd7adns8	519	1	Hydroxycarbamide	Hydroxycarbamide	NNP
cord-023168-cd7adns8	519	2	may	may	MD
cord-023168-cd7adns8	519	3	decrease	decrease	VB
cord-023168-cd7adns8	519	4	the	the	DT
cord-023168-cd7adns8	519	5	risk	risk	NN
cord-023168-cd7adns8	519	6	•	•	XX
cord-023168-cd7adns8	520	1	Prostacycline	Prostacycline	NNP
cord-023168-cd7adns8	520	2	analogues	analogue	NNS
cord-023168-cd7adns8	520	3	(	(	-LRB-
cord-023168-cd7adns8	520	4	epoprostenol	epoprostenol	NNP
cord-023168-cd7adns8	520	5	,	,	,
cord-023168-cd7adns8	520	6	and	and	CC
cord-023168-cd7adns8	520	7	iloprost	iloprost	NN
cord-023168-cd7adns8	520	8	)	)	-RRB-
cord-023168-cd7adns8	520	9	,	,	,
cord-023168-cd7adns8	520	10	endothelin-1	endothelin-1	NNP
cord-023168-cd7adns8	520	11	receptor	receptor	NN
cord-023168-cd7adns8	520	12	antagonists	antagonist	NNS
cord-023168-cd7adns8	520	13	(	(	-LRB-
cord-023168-cd7adns8	520	14	bosentan	bosentan	NNP
cord-023168-cd7adns8	520	15	)	)	-RRB-
cord-023168-cd7adns8	520	16	,	,	,
cord-023168-cd7adns8	520	17	phosphodiesterase	phosphodiesterase	NN
cord-023168-cd7adns8	520	18	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	520	19	(	(	-LRB-
cord-023168-cd7adns8	520	20	including	include	VBG
cord-023168-cd7adns8	520	21	sildenafil	sildenafil	NNP
cord-023168-cd7adns8	520	22	)	)	-RRB-
cord-023168-cd7adns8	520	23	,	,	,
cord-023168-cd7adns8	520	24	and	and	CC
cord-023168-cd7adns8	520	25	calcium	calcium	NN
cord-023168-cd7adns8	520	26	channel	channel	NN
cord-023168-cd7adns8	520	27	blockers	blocker	NNS
cord-023168-cd7adns8	520	28	are	be	VBP
cord-023168-cd7adns8	520	29	being	be	VBG
cord-023168-cd7adns8	520	30	evaluated	evaluate	VBN
cord-023168-cd7adns8	520	31	.	.	.
cord-023168-cd7adns8	521	1	•	•	NNP
cord-023168-cd7adns8	522	1	Brief	brief	JJ
cord-023168-cd7adns8	522	2	but	but	CC
cord-023168-cd7adns8	522	3	recurrent	recurrent	JJ
cord-023168-cd7adns8	522	4	(	(	-LRB-
cord-023168-cd7adns8	522	5	stuttering	stutter	VBG
cord-023168-cd7adns8	522	6	)	)	-RRB-
cord-023168-cd7adns8	522	7	;	;	:
cord-023168-cd7adns8	522	8	may	may	MD
cord-023168-cd7adns8	522	9	occasionally	occasionally	RB
cord-023168-cd7adns8	522	10	last	last	VB
cord-023168-cd7adns8	522	11	for	for	IN
cord-023168-cd7adns8	522	12	many	many	JJ
cord-023168-cd7adns8	522	13	hours	hour	NNS
cord-023168-cd7adns8	522	14	and	and	CC
cord-023168-cd7adns8	522	15	can	can	MD
cord-023168-cd7adns8	522	16	lead	lead	VB
cord-023168-cd7adns8	522	17	to	to	IN
cord-023168-cd7adns8	522	18	impotence	impotence	NN
cord-023168-cd7adns8	522	19	•	•	XX
cord-023168-cd7adns8	523	1	Usually	usually	RB
cord-023168-cd7adns8	523	2	ischaemic	ischaemic	JJ
cord-023168-cd7adns8	523	3	,	,	,
cord-023168-cd7adns8	523	4	or	or	CC
cord-023168-cd7adns8	523	5	low	low	JJ
cord-023168-cd7adns8	523	6	-	-	HYPH
cord-023168-cd7adns8	523	7	flow	flow	NN
cord-023168-cd7adns8	524	1	,	,	,
cord-023168-cd7adns8	524	2	priapism	priapism	NN
cord-023168-cd7adns8	524	3	•	•	NNP
cord-023168-cd7adns8	525	1	Patients	patient	NNS
cord-023168-cd7adns8	525	2	should	should	MD
cord-023168-cd7adns8	525	3	be	be	VB
cord-023168-cd7adns8	525	4	educated	educate	VBN
cord-023168-cd7adns8	525	5	to	to	TO
cord-023168-cd7adns8	525	6	seek	seek	VB
cord-023168-cd7adns8	525	7	medical	medical	JJ
cord-023168-cd7adns8	525	8	attention	attention	NN
cord-023168-cd7adns8	525	9	if	if	IN
cord-023168-cd7adns8	525	10	more	more	JJR
cord-023168-cd7adns8	525	11	than	than	IN
cord-023168-cd7adns8	525	12	2	2	CD
cord-023168-cd7adns8	525	13	hours	hour	NNS
cord-023168-cd7adns8	525	14	duration	duration	NN
cord-023168-cd7adns8	526	1	•	•	NNP
cord-023168-cd7adns8	527	1	Detumescence	Detumescence	NNP
cord-023168-cd7adns8	527	2	within	within	IN
cord-023168-cd7adns8	527	3	12	12	CD
cord-023168-cd7adns8	527	4	hours	hour	NNS
cord-023168-cd7adns8	527	5	is	be	VBZ
cord-023168-cd7adns8	527	6	necessary	necessary	JJ
cord-023168-cd7adns8	527	7	to	to	TO
cord-023168-cd7adns8	527	8	retain	retain	VB
cord-023168-cd7adns8	527	9	potency	potency	NN
cord-023168-cd7adns8	527	10	•	•	NN
cord-023168-cd7adns8	528	1	Intravenous	intravenous	JJ
cord-023168-cd7adns8	528	2	hydration	hydration	NN
cord-023168-cd7adns8	528	3	and	and	CC
cord-023168-cd7adns8	528	4	analgesia	analgesia	NN
cord-023168-cd7adns8	528	5	initially	initially	RB
cord-023168-cd7adns8	528	6	with	with	IN
cord-023168-cd7adns8	528	7	consideration	consideration	NN
cord-023168-cd7adns8	528	8	for	for	IN
cord-023168-cd7adns8	528	9	α	α	NN
cord-023168-cd7adns8	528	10	-	-	HYPH
cord-023168-cd7adns8	528	11	adrenergic	adrenergic	NN
cord-023168-cd7adns8	528	12	agonists	agonist	NNS
cord-023168-cd7adns8	528	13	(	(	-LRB-
cord-023168-cd7adns8	528	14	etilefrine	etilefrine	NNP
cord-023168-cd7adns8	528	15	or	or	CC
cord-023168-cd7adns8	528	16	phenylephrine	phenylephrine	NN
cord-023168-cd7adns8	528	17	)	)	-RRB-
cord-023168-cd7adns8	529	1	•	•	NNP
cord-023168-cd7adns8	530	1	Penile	penile	JJ
cord-023168-cd7adns8	530	2	aspiration	aspiration	NN
cord-023168-cd7adns8	530	3	and	and	CC
cord-023168-cd7adns8	530	4	irrigation	irrigation	NN
cord-023168-cd7adns8	530	5	with	with	IN
cord-023168-cd7adns8	530	6	saline	saline	NN
cord-023168-cd7adns8	530	7	and	and	CC
cord-023168-cd7adns8	530	8	α	α	NN
cord-023168-cd7adns8	530	9	-	-	HYPH
cord-023168-cd7adns8	530	10	adrenergic	adrenergic	NN
cord-023168-cd7adns8	530	11	agents	agent	NNS
cord-023168-cd7adns8	530	12	or	or	CC
cord-023168-cd7adns8	530	13	shunting	shunting	NN
cord-023168-cd7adns8	530	14	may	may	MD
cord-023168-cd7adns8	530	15	be	be	VB
cord-023168-cd7adns8	530	16	required	require	VBN
cord-023168-cd7adns8	530	17	in	in	IN
cord-023168-cd7adns8	530	18	severe	severe	JJ
cord-023168-cd7adns8	530	19	cases	case	NNS
cord-023168-cd7adns8	530	20	in	in	IN
cord-023168-cd7adns8	530	21	combination	combination	NN
cord-023168-cd7adns8	530	22	with	with	IN
cord-023168-cd7adns8	530	23	an	an	DT
cord-023168-cd7adns8	530	24	exchange	exchange	NN
cord-023168-cd7adns8	530	25	transfusion	transfusion	NN
cord-023168-cd7adns8	530	26	.	.	.
cord-023168-cd7adns8	531	1	•	•	NNP
cord-023168-cd7adns8	532	1	Assess	assess	VB
cord-023168-cd7adns8	532	2	pain	pain	NN
cord-023168-cd7adns8	532	3	intensity	intensity	NN
cord-023168-cd7adns8	533	1	•	•	NNP
cord-023168-cd7adns8	533	2	Choose	choose	VB
cord-023168-cd7adns8	533	3	the	the	DT
cord-023168-cd7adns8	533	4	analgesic	analgesic	JJ
cord-023168-cd7adns8	533	5	,	,	,
cord-023168-cd7adns8	533	6	dosage	dosage	NN
cord-023168-cd7adns8	533	7	,	,	,
cord-023168-cd7adns8	533	8	and	and	CC
cord-023168-cd7adns8	533	9	route	route	NN
cord-023168-cd7adns8	533	10	of	of	IN
cord-023168-cd7adns8	533	11	administration	administration	NN
cord-023168-cd7adns8	534	1	•	•	NNP
cord-023168-cd7adns8	535	1	Paracetamol	Paracetamol	NNP
cord-023168-cd7adns8	535	2	and	and	CC
cord-023168-cd7adns8	535	3	hydration	hydration	NN
cord-023168-cd7adns8	535	4	should	should	MD
cord-023168-cd7adns8	535	5	be	be	VB
cord-023168-cd7adns8	535	6	considered	consider	VBN
cord-023168-cd7adns8	535	7	in	in	IN
cord-023168-cd7adns8	535	8	all	all	DT
cord-023168-cd7adns8	535	9	patients	patient	NNS
cord-023168-cd7adns8	536	1	•	•	NNP
cord-023168-cd7adns8	537	1	Oral	oral	JJ
cord-023168-cd7adns8	537	2	,	,	,
cord-023168-cd7adns8	537	3	sustained	sustain	VBN
cord-023168-cd7adns8	537	4	-	-	HYPH
cord-023168-cd7adns8	537	5	release	release	NN
cord-023168-cd7adns8	537	6	morphine	morphine	NN
cord-023168-cd7adns8	537	7	is	be	VBZ
cord-023168-cd7adns8	537	8	as	as	RB
cord-023168-cd7adns8	537	9	good	good	JJ
cord-023168-cd7adns8	537	10	as	as	IN
cord-023168-cd7adns8	537	11	intravenous	intravenous	JJ
cord-023168-cd7adns8	537	12	morphine	morphine	NN
cord-023168-cd7adns8	537	13	infusion	infusion	NN
cord-023168-cd7adns8	537	14	in	in	IN
cord-023168-cd7adns8	537	15	children	child	NNS
cord-023168-cd7adns8	537	16	and	and	CC
cord-023168-cd7adns8	537	17	young	young	JJ
cord-023168-cd7adns8	537	18	adults	adult	NNS
cord-023168-cd7adns8	538	1	•	•	NNP
cord-023168-cd7adns8	539	1	Manage	manage	VB
cord-023168-cd7adns8	539	2	mild	mild	JJ
cord-023168-cd7adns8	539	3	pain	pain	NN
cord-023168-cd7adns8	539	4	with	with	IN
cord-023168-cd7adns8	539	5	rest	rest	NN
cord-023168-cd7adns8	539	6	,	,	,
cord-023168-cd7adns8	539	7	hydration	hydration	NN
cord-023168-cd7adns8	539	8	,	,	,
cord-023168-cd7adns8	539	9	and	and	CC
cord-023168-cd7adns8	539	10	weak	weak	JJ
cord-023168-cd7adns8	539	11	opioids	opioid	NNS
cord-023168-cd7adns8	539	12	(	(	-LRB-
cord-023168-cd7adns8	539	13	such	such	JJ
cord-023168-cd7adns8	539	14	as	as	IN
cord-023168-cd7adns8	539	15	codeine	codeine	NN
cord-023168-cd7adns8	539	16	)	)	-RRB-
cord-023168-cd7adns8	539	17	.	.	.
cord-023168-cd7adns8	540	1	Admit	admit	VBP
cord-023168-cd7adns8	540	2	patients	patient	NNS
cord-023168-cd7adns8	540	3	in	in	IN
cord-023168-cd7adns8	540	4	whom	whom	WP
cord-023168-cd7adns8	540	5	pain	pain	NN
cord-023168-cd7adns8	540	6	that	that	WDT
cord-023168-cd7adns8	540	7	does	do	VBZ
cord-023168-cd7adns8	540	8	not	not	RB
cord-023168-cd7adns8	540	9	subside	subside	VB
cord-023168-cd7adns8	540	10	promptly	promptly	RB
cord-023168-cd7adns8	540	11	or	or	CC
cord-023168-cd7adns8	540	12	require	require	VB
cord-023168-cd7adns8	540	13	opioid	opioid	JJ
cord-023168-cd7adns8	540	14	treatment	treatment	NN
cord-023168-cd7adns8	540	15	;	;	:
cord-023168-cd7adns8	540	16	fever	fever	NN
cord-023168-cd7adns8	540	17	,	,	,
cord-023168-cd7adns8	540	18	pallor	pallor	NN
cord-023168-cd7adns8	540	19	,	,	,
cord-023168-cd7adns8	540	20	or	or	CC
cord-023168-cd7adns8	540	21	signs	sign	NNS
cord-023168-cd7adns8	540	22	of	of	IN
cord-023168-cd7adns8	540	23	respiratory	respiratory	JJ
cord-023168-cd7adns8	540	24	compromise	compromise	NN
cord-023168-cd7adns8	540	25	;	;	:
cord-023168-cd7adns8	540	26	a	a	DT
cord-023168-cd7adns8	540	27	low	low	JJ
cord-023168-cd7adns8	540	28	likelihood	likelihood	NN
cord-023168-cd7adns8	540	29	of	of	IN
cord-023168-cd7adns8	540	30	receiving	receive	VBG
cord-023168-cd7adns8	540	31	appropriate	appropriate	JJ
cord-023168-cd7adns8	540	32	care	care	NN
cord-023168-cd7adns8	540	33	at	at	IN
cord-023168-cd7adns8	540	34	home	home	NN
cord-023168-cd7adns8	541	1	•	•	NNP
cord-023168-cd7adns8	542	1	Pain	pain	NN
cord-023168-cd7adns8	542	2	management	management	NN
cord-023168-cd7adns8	542	3	should	should	MD
cord-023168-cd7adns8	542	4	be	be	VB
cord-023168-cd7adns8	542	5	individualized	individualized	JJ
cord-023168-cd7adns8	542	6	and	and	CC
cord-023168-cd7adns8	542	7	dosing	dosing	NN
cord-023168-cd7adns8	542	8	should	should	MD
cord-023168-cd7adns8	542	9	take	take	VB
cord-023168-cd7adns8	542	10	into	into	IN
cord-023168-cd7adns8	542	11	account	account	NN
cord-023168-cd7adns8	542	12	prior	prior	JJ
cord-023168-cd7adns8	542	13	pain	pain	NN
cord-023168-cd7adns8	542	14	management	management	NN
cord-023168-cd7adns8	542	15	and	and	CC
cord-023168-cd7adns8	542	16	use	use	NN
cord-023168-cd7adns8	542	17	of	of	IN
cord-023168-cd7adns8	542	18	opioids	opioid	NNS
cord-023168-cd7adns8	542	19	•	•	XX
cord-023168-cd7adns8	543	1	The	the	DT
cord-023168-cd7adns8	543	2	pain	pain	NN
cord-023168-cd7adns8	543	3	pathway	pathway	NN
cord-023168-cd7adns8	543	4	should	should	MD
cord-023168-cd7adns8	543	5	be	be	VB
cord-023168-cd7adns8	543	6	targeted	target	VBN
cord-023168-cd7adns8	543	7	at	at	IN
cord-023168-cd7adns8	543	8	different	different	JJ
cord-023168-cd7adns8	543	9	points	point	NNS
cord-023168-cd7adns8	543	10	with	with	IN
cord-023168-cd7adns8	543	11	different	different	JJ
cord-023168-cd7adns8	543	12	agents	agent	NNS
cord-023168-cd7adns8	543	13	,	,	,
cord-023168-cd7adns8	543	14	avoiding	avoid	VBG
cord-023168-cd7adns8	543	15	toxicity	toxicity	NN
cord-023168-cd7adns8	543	16	with	with	IN
cord-023168-cd7adns8	543	17	any	any	DT
cord-023168-cd7adns8	543	18	one	one	CD
cord-023168-cd7adns8	543	19	class	class	NN
cord-023168-cd7adns8	544	1	•	•	NNP
cord-023168-cd7adns8	545	1	Always	always	RB
cord-023168-cd7adns8	545	2	look	look	VB
cord-023168-cd7adns8	545	3	for	for	IN
cord-023168-cd7adns8	545	4	a	a	DT
cord-023168-cd7adns8	545	5	cause	cause	NN
cord-023168-cd7adns8	545	6	,	,	,
cord-023168-cd7adns8	545	7	e.g.	e.g.	RB
cord-023168-cd7adns8	545	8	infection	infection	NN
cord-023168-cd7adns8	545	9	,	,	,
cord-023168-cd7adns8	545	10	dehydration	dehydration	NN
cord-023168-cd7adns8	545	11	,	,	,
cord-023168-cd7adns8	545	12	etc	etc	FW
cord-023168-cd7adns8	545	13	.	.	.
cord-023168-cd7adns8	546	1	•	•	NNP
cord-023168-cd7adns8	547	1	Education	education	NN
cord-023168-cd7adns8	547	2	about	about	IN
cord-023168-cd7adns8	547	3	avoiding	avoid	VBG
cord-023168-cd7adns8	547	4	exposure	exposure	NN
cord-023168-cd7adns8	547	5	to	to	IN
cord-023168-cd7adns8	547	6	precipitants	precipitant	NNS
cord-023168-cd7adns8	547	7	•	•	NNP
cord-023168-cd7adns8	548	1	Be	be	VB
cord-023168-cd7adns8	548	2	empathetic	empathetic	JJ
cord-023168-cd7adns8	548	3	,	,	,
cord-023168-cd7adns8	548	4	reassuring	reassuring	JJ
cord-023168-cd7adns8	548	5	,	,	,
cord-023168-cd7adns8	548	6	and	and	CC
cord-023168-cd7adns8	548	7	supportive	supportive	JJ
cord-023168-cd7adns8	548	8	•	•	NN
cord-023168-cd7adns8	549	1	Benzodiazepines	benzodiazepine	NNS
cord-023168-cd7adns8	549	2	may	may	MD
cord-023168-cd7adns8	549	3	be	be	VB
cord-023168-cd7adns8	549	4	helpful	helpful	JJ
cord-023168-cd7adns8	549	5	to	to	TO
cord-023168-cd7adns8	549	6	reduce	reduce	VB
cord-023168-cd7adns8	549	7	anxiety	anxiety	NN
cord-023168-cd7adns8	550	1	•	•	NNP
cord-023168-cd7adns8	550	2	Re	re	IN
cord-023168-cd7adns8	550	3	-	-	VB
cord-023168-cd7adns8	550	4	examine	examine	VB
cord-023168-cd7adns8	550	5	the	the	DT
cord-023168-cd7adns8	550	6	patient	patient	NN
cord-023168-cd7adns8	550	7	often	often	RB
cord-023168-cd7adns8	550	8	to	to	TO
cord-023168-cd7adns8	550	9	ensure	ensure	VB
cord-023168-cd7adns8	550	10	adequate	adequate	JJ
cord-023168-cd7adns8	550	11	pain	pain	NN
cord-023168-cd7adns8	550	12	relief	relief	NN
cord-023168-cd7adns8	550	13	,	,	,
cord-023168-cd7adns8	550	14	to	to	TO
cord-023168-cd7adns8	550	15	assess	assess	VB
cord-023168-cd7adns8	550	16	sedation	sedation	NN
cord-023168-cd7adns8	550	17	and	and	CC
cord-023168-cd7adns8	550	18	respiratory	respiratory	JJ
cord-023168-cd7adns8	550	19	rate	rate	NN
cord-023168-cd7adns8	550	20	(	(	-LRB-
cord-023168-cd7adns8	550	21	to	to	TO
cord-023168-cd7adns8	550	22	avoid	avoid	VB
cord-023168-cd7adns8	550	23	opioid	opioid	JJ
cord-023168-cd7adns8	550	24	overdose	overdose	NN
cord-023168-cd7adns8	550	25	)	)	-RRB-
cord-023168-cd7adns8	550	26	.	.	.
cord-023168-cd7adns8	551	1	In	in	IN
cord-023168-cd7adns8	551	2	assessing	assess	VBG
cord-023168-cd7adns8	551	3	patient	patient	NN
cord-023168-cd7adns8	551	4	responses	response	NNS
cord-023168-cd7adns8	551	5	to	to	IN
cord-023168-cd7adns8	551	6	conventional	conventional	JJ
cord-023168-cd7adns8	551	7	doses	dose	NNS
cord-023168-cd7adns8	551	8	of	of	IN
cord-023168-cd7adns8	551	9	analgesia	analgesia	NN
cord-023168-cd7adns8	551	10	,	,	,
cord-023168-cd7adns8	551	11	it	-PRON-	PRP
cord-023168-cd7adns8	551	12	must	must	MD
cord-023168-cd7adns8	551	13	be	be	VB
cord-023168-cd7adns8	551	14	remembered	remember	VBN
cord-023168-cd7adns8	551	15	that	that	IN
cord-023168-cd7adns8	551	16	those	those	DT
cord-023168-cd7adns8	551	17	with	with	IN
cord-023168-cd7adns8	551	18	sickle	sickle	NN
cord-023168-cd7adns8	551	19	cell	cell	NN
cord-023168-cd7adns8	551	20	disease	disease	NN
cord-023168-cd7adns8	551	21	metabolize	metabolize	VB
cord-023168-cd7adns8	551	22	narcotics	narcotic	NNS
cord-023168-cd7adns8	551	23	rapidly	rapidly	RB
cord-023168-cd7adns8	551	24	•	•	NNP
cord-023168-cd7adns8	552	1	Re	re	NN
cord-023168-cd7adns8	552	2	-	-	NN
cord-023168-cd7adns8	552	3	search	search	VB
cord-023168-cd7adns8	552	4	for	for	IN
cord-023168-cd7adns8	552	5	evidence	evidence	NN
cord-023168-cd7adns8	552	6	of	of	IN
cord-023168-cd7adns8	552	7	any	any	DT
cord-023168-cd7adns8	552	8	complications	complication	NNS
cord-023168-cd7adns8	552	9	such	such	JJ
cord-023168-cd7adns8	552	10	as	as	IN
cord-023168-cd7adns8	552	11	acute	acute	JJ
cord-023168-cd7adns8	552	12	chest	chest	NN
cord-023168-cd7adns8	552	13	syndrome	syndrome	NN
cord-023168-cd7adns8	552	14	or	or	CC
cord-023168-cd7adns8	552	15	anaemia	anaemia	NN
cord-023168-cd7adns8	553	1	•	•	NNP
cord-023168-cd7adns8	554	1	Always	always	RB
cord-023168-cd7adns8	554	2	look	look	VB
cord-023168-cd7adns8	554	3	for	for	IN
cord-023168-cd7adns8	554	4	a	a	DT
cord-023168-cd7adns8	554	5	cause	cause	NN
cord-023168-cd7adns8	554	6	,	,	,
cord-023168-cd7adns8	554	7	e.g.	e.g.	RB
cord-023168-cd7adns8	554	8	infection	infection	NN
cord-023168-cd7adns8	554	9	.	.	.
cord-023168-cd7adns8	555	1	of	of	IN
cord-023168-cd7adns8	555	2	multi	multi	JJ
cord-023168-cd7adns8	555	3	-	-	JJ
cord-023168-cd7adns8	555	4	organ	organ	JJ
cord-023168-cd7adns8	555	5	failure	failure	NN
cord-023168-cd7adns8	555	6	.	.	.
cord-023168-cd7adns8	556	1	116	116	CD
cord-023168-cd7adns8	557	1	Both	both	DT
cord-023168-cd7adns8	557	2	simple	simple	JJ
cord-023168-cd7adns8	557	3	transfusion	transfusion	NN
cord-023168-cd7adns8	557	4	and	and	CC
cord-023168-cd7adns8	557	5	exchange	exchange	NN
cord-023168-cd7adns8	557	6	transfusions	transfusion	NNS
cord-023168-cd7adns8	557	7	have	have	VBP
cord-023168-cd7adns8	557	8	been	be	VBN
cord-023168-cd7adns8	557	9	used	use	VBN
cord-023168-cd7adns8	557	10	and	and	CC
cord-023168-cd7adns8	557	11	neither	neither	DT
cord-023168-cd7adns8	557	12	appears	appear	VBZ
cord-023168-cd7adns8	557	13	to	to	TO
cord-023168-cd7adns8	557	14	be	be	VB
cord-023168-cd7adns8	557	15	superior	superior	JJ
cord-023168-cd7adns8	557	16	.	.	.
cord-023168-cd7adns8	558	1	A	a	DT
cord-023168-cd7adns8	558	2	short	short	JJ
cord-023168-cd7adns8	558	3	course	course	NN
cord-023168-cd7adns8	558	4	of	of	IN
cord-023168-cd7adns8	558	5	steroids	steroid	NNS
cord-023168-cd7adns8	558	6	may	may	MD
cord-023168-cd7adns8	558	7	attenuate	attenuate	VB
cord-023168-cd7adns8	558	8	ACS	ACS	NNP
cord-023168-cd7adns8	559	1	but	but	CC
cord-023168-cd7adns8	559	2	it	-PRON-	PRP
cord-023168-cd7adns8	559	3	may	may	MD
cord-023168-cd7adns8	559	4	also	also	RB
cord-023168-cd7adns8	559	5	increase	increase	VB
cord-023168-cd7adns8	559	6	the	the	DT
cord-023168-cd7adns8	559	7	risk	risk	NN
cord-023168-cd7adns8	559	8	of	of	IN
cord-023168-cd7adns8	559	9	re	re	NN
cord-023168-cd7adns8	559	10	-	-	NN
cord-023168-cd7adns8	559	11	hospitalization	hospitalization	NN
cord-023168-cd7adns8	559	12	.	.	.
cord-023168-cd7adns8	560	1	117	117	CD
cord-023168-cd7adns8	560	2	Bronchodilators	Bronchodilators	NNP
cord-023168-cd7adns8	560	3	may	may	MD
cord-023168-cd7adns8	560	4	help	help	VB
cord-023168-cd7adns8	560	5	patients	patient	NNS
cord-023168-cd7adns8	560	6	with	with	IN
cord-023168-cd7adns8	560	7	wheezing	wheeze	VBG
cord-023168-cd7adns8	560	8	118	118	CD
cord-023168-cd7adns8	560	9	but	but	CC
cord-023168-cd7adns8	560	10	inhaled	inhale	VBN
cord-023168-cd7adns8	560	11	nitric	nitric	NN
cord-023168-cd7adns8	560	12	oxide	oxide	NN
cord-023168-cd7adns8	560	13	has	have	VBZ
cord-023168-cd7adns8	560	14	not	not	RB
cord-023168-cd7adns8	560	15	shown	show	VBN
cord-023168-cd7adns8	560	16	any	any	DT
cord-023168-cd7adns8	560	17	clear	clear	JJ
cord-023168-cd7adns8	560	18	benefits	benefit	NNS
cord-023168-cd7adns8	560	19	.	.	.
cord-023168-cd7adns8	561	1	119	119	CD
cord-023168-cd7adns8	562	1	Since	since	IN
cord-023168-cd7adns8	562	2	coagulation	coagulation	NN
cord-023168-cd7adns8	562	3	activation	activation	NN
cord-023168-cd7adns8	562	4	is	be	VBZ
cord-023168-cd7adns8	562	5	important	important	JJ
cord-023168-cd7adns8	562	6	in	in	IN
cord-023168-cd7adns8	562	7	the	the	DT
cord-023168-cd7adns8	562	8	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	562	9	of	of	IN
cord-023168-cd7adns8	562	10	acute	acute	JJ
cord-023168-cd7adns8	562	11	chest	chest	NN
cord-023168-cd7adns8	562	12	syndrome	syndrome	NN
cord-023168-cd7adns8	562	13	,	,	,
cord-023168-cd7adns8	562	14	treatment	treatment	NN
cord-023168-cd7adns8	562	15	with	with	IN
cord-023168-cd7adns8	562	16	low	low	JJ
cord-023168-cd7adns8	562	17	-	-	HYPH
cord-023168-cd7adns8	562	18	molecular	molecular	JJ
cord-023168-cd7adns8	562	19	-	-	HYPH
cord-023168-cd7adns8	562	20	weight	weight	NN
cord-023168-cd7adns8	562	21	heparin	heparin	NN
cord-023168-cd7adns8	562	22	may	may	MD
cord-023168-cd7adns8	562	23	reduce	reduce	VB
cord-023168-cd7adns8	562	24	clinical	clinical	JJ
cord-023168-cd7adns8	562	25	complications	complication	NNS
cord-023168-cd7adns8	562	26	.	.	.
cord-023168-cd7adns8	563	1	120	120	CD
cord-023168-cd7adns8	563	2	Transcranial	Transcranial	NNP
cord-023168-cd7adns8	563	3	Doppler	Doppler	NNP
cord-023168-cd7adns8	563	4	measurement	measurement	NN
cord-023168-cd7adns8	563	5	of	of	IN
cord-023168-cd7adns8	563	6	cerebral	cerebral	JJ
cord-023168-cd7adns8	563	7	blood	blood	NN
cord-023168-cd7adns8	563	8	flow	flow	NN
cord-023168-cd7adns8	563	9	has	have	VBZ
cord-023168-cd7adns8	563	10	been	be	VBN
cord-023168-cd7adns8	563	11	a	a	DT
cord-023168-cd7adns8	563	12	major	major	JJ
cord-023168-cd7adns8	563	13	step	step	NN
cord-023168-cd7adns8	563	14	forwards	forwards	RB
cord-023168-cd7adns8	563	15	in	in	IN
cord-023168-cd7adns8	563	16	identifying	identify	VBG
cord-023168-cd7adns8	563	17	individuals	individual	NNS
cord-023168-cd7adns8	563	18	with	with	IN
cord-023168-cd7adns8	563	19	an	an	DT
cord-023168-cd7adns8	563	20	increased	increase	VBN
cord-023168-cd7adns8	563	21	risk	risk	NN
cord-023168-cd7adns8	563	22	of	of	IN
cord-023168-cd7adns8	563	23	ischaemic	ischaemic	JJ
cord-023168-cd7adns8	563	24	stroke	stroke	NN
cord-023168-cd7adns8	563	25	.	.	.
cord-023168-cd7adns8	564	1	A	a	DT
cord-023168-cd7adns8	564	2	value	value	NN
cord-023168-cd7adns8	564	3	more	more	JJR
cord-023168-cd7adns8	564	4	than	than	IN
cord-023168-cd7adns8	564	5	200	200	CD
cord-023168-cd7adns8	564	6	cm/	cm/	NN
cord-023168-cd7adns8	564	7	second	second	NN
cord-023168-cd7adns8	564	8	imparts	impart	VBZ
cord-023168-cd7adns8	564	9	a	a	DT
cord-023168-cd7adns8	564	10	40	40	CD
cord-023168-cd7adns8	564	11	%	%	NN
cord-023168-cd7adns8	564	12	risk	risk	NN
cord-023168-cd7adns8	564	13	of	of	IN
cord-023168-cd7adns8	564	14	stroke	stroke	NN
cord-023168-cd7adns8	564	15	within	within	IN
cord-023168-cd7adns8	564	16	the	the	DT
cord-023168-cd7adns8	564	17	next	next	JJ
cord-023168-cd7adns8	564	18	3	3	CD
cord-023168-cd7adns8	564	19	years	year	NNS
cord-023168-cd7adns8	564	20	.	.	.
cord-023168-cd7adns8	565	1	121	121	CD
cord-023168-cd7adns8	565	2	Regular	regular	JJ
cord-023168-cd7adns8	565	3	blood	blood	NN
cord-023168-cd7adns8	565	4	transfusions	transfusion	NNS
cord-023168-cd7adns8	565	5	can	can	MD
cord-023168-cd7adns8	565	6	reduce	reduce	VB
cord-023168-cd7adns8	565	7	the	the	DT
cord-023168-cd7adns8	565	8	incidence	incidence	NN
cord-023168-cd7adns8	565	9	of	of	IN
cord-023168-cd7adns8	565	10	stroke	stroke	NN
cord-023168-cd7adns8	565	11	in	in	IN
cord-023168-cd7adns8	565	12	children	child	NNS
cord-023168-cd7adns8	565	13	.	.	.
cord-023168-cd7adns8	566	1	105	105	CD
cord-023168-cd7adns8	567	1	Due	due	IN
cord-023168-cd7adns8	567	2	to	to	IN
cord-023168-cd7adns8	567	3	a	a	DT
cord-023168-cd7adns8	567	4	high	high	JJ
cord-023168-cd7adns8	567	5	recurrence	recurrence	NN
cord-023168-cd7adns8	567	6	of	of	IN
cord-023168-cd7adns8	567	7	stroke	stroke	NN
cord-023168-cd7adns8	567	8	(	(	-LRB-
cord-023168-cd7adns8	567	9	60	60	CD
cord-023168-cd7adns8	567	10	%	%	NN
cord-023168-cd7adns8	567	11	)	)	-RRB-
cord-023168-cd7adns8	567	12	on	on	IN
cord-023168-cd7adns8	567	13	stopping	stop	VBG
cord-023168-cd7adns8	567	14	transfusions	transfusion	NNS
cord-023168-cd7adns8	567	15	,	,	,
cord-023168-cd7adns8	567	16	continuation	continuation	NN
cord-023168-cd7adns8	567	17	of	of	IN
cord-023168-cd7adns8	567	18	transfusions	transfusion	NNS
cord-023168-cd7adns8	567	19	should	should	MD
cord-023168-cd7adns8	567	20	be	be	VB
cord-023168-cd7adns8	567	21	guided	guide	VBN
cord-023168-cd7adns8	567	22	by	by	IN
cord-023168-cd7adns8	567	23	transcranial	transcranial	JJ
cord-023168-cd7adns8	567	24	Doppler	Doppler	NNP
cord-023168-cd7adns8	567	25	measurements	measurement	NNS
cord-023168-cd7adns8	567	26	.	.	.
cord-023168-cd7adns8	568	1	122	122	CD
cord-023168-cd7adns8	568	2	,	,	,
cord-023168-cd7adns8	568	3	123	123	CD
cord-023168-cd7adns8	568	4	Once	once	IN
cord-023168-cd7adns8	568	5	a	a	DT
cord-023168-cd7adns8	568	6	stroke	stroke	NN
cord-023168-cd7adns8	568	7	has	have	VBZ
cord-023168-cd7adns8	568	8	developed	develop	VBN
cord-023168-cd7adns8	568	9	,	,	,
cord-023168-cd7adns8	568	10	the	the	DT
cord-023168-cd7adns8	568	11	best	good	JJS
cord-023168-cd7adns8	568	12	therapeutic	therapeutic	JJ
cord-023168-cd7adns8	568	13	strategy	strategy	NN
cord-023168-cd7adns8	568	14	is	be	VBZ
cord-023168-cd7adns8	568	15	exchange	exchange	NN
cord-023168-cd7adns8	568	16	transfusion	transfusion	NN
cord-023168-cd7adns8	568	17	which	which	WDT
cord-023168-cd7adns8	568	18	probably	probably	RB
cord-023168-cd7adns8	568	19	needs	need	VBZ
cord-023168-cd7adns8	568	20	to	to	TO
cord-023168-cd7adns8	568	21	be	be	VB
cord-023168-cd7adns8	568	22	done	do	VBN
cord-023168-cd7adns8	568	23	monthly	monthly	RB
cord-023168-cd7adns8	568	24	.	.	.
cord-023168-cd7adns8	569	1	70	70	CD
cord-023168-cd7adns8	569	2	,	,	,
cord-023168-cd7adns8	569	3	73	73	CD
cord-023168-cd7adns8	569	4	Neurosurgical	neurosurgical	JJ
cord-023168-cd7adns8	569	5	re	re	NN
cord-023168-cd7adns8	569	6	-	-	NN
cord-023168-cd7adns8	569	7	vascularization	vascularization	NN
cord-023168-cd7adns8	569	8	should	should	MD
cord-023168-cd7adns8	569	9	be	be	VB
cord-023168-cd7adns8	569	10	considered	consider	VBN
cord-023168-cd7adns8	569	11	for	for	IN
cord-023168-cd7adns8	569	12	moyamoya	moyamoya	NNP
cord-023168-cd7adns8	569	13	-	-	HYPH
cord-023168-cd7adns8	569	14	like	like	JJ
cord-023168-cd7adns8	569	15	syndromes	syndrome	NNS
cord-023168-cd7adns8	569	16	when	when	WRB
cord-023168-cd7adns8	569	17	new	new	JJ
cord-023168-cd7adns8	569	18	strokes	stroke	NNS
cord-023168-cd7adns8	569	19	occur	occur	VBP
cord-023168-cd7adns8	569	20	despite	despite	IN
cord-023168-cd7adns8	569	21	transfusion	transfusion	NN
cord-023168-cd7adns8	569	22	.	.	.
cord-023168-cd7adns8	570	1	Haemoglobin	Haemoglobin	NNP
cord-023168-cd7adns8	570	2	SC	SC	NNP
cord-023168-cd7adns8	570	3	results	result	NNS
cord-023168-cd7adns8	570	4	from	from	IN
cord-023168-cd7adns8	570	5	the	the	DT
cord-023168-cd7adns8	570	6	co	co	NN
cord-023168-cd7adns8	570	7	-	-	NN
cord-023168-cd7adns8	570	8	inheritance	inheritance	NN
cord-023168-cd7adns8	570	9	of	of	IN
cord-023168-cd7adns8	570	10	HbS	hbs	NN
cord-023168-cd7adns8	570	11	and	and	CC
cord-023168-cd7adns8	570	12	HbC	HbC	NNP
cord-023168-cd7adns8	570	13	and	and	CC
cord-023168-cd7adns8	570	14	has	have	VBZ
cord-023168-cd7adns8	570	15	its	-PRON-	PRP$
cord-023168-cd7adns8	570	16	highest	high	JJS
cord-023168-cd7adns8	570	17	prevalence	prevalence	NN
cord-023168-cd7adns8	570	18	in	in	IN
cord-023168-cd7adns8	570	19	West	West	NNP
cord-023168-cd7adns8	570	20	Africa	Africa	NNP
cord-023168-cd7adns8	570	21	.	.	.
cord-023168-cd7adns8	571	1	Clinical	clinical	JJ
cord-023168-cd7adns8	571	2	features	feature	NNS
cord-023168-cd7adns8	571	3	and	and	CC
cord-023168-cd7adns8	571	4	disease	disease	NN
cord-023168-cd7adns8	571	5	management	management	NN
cord-023168-cd7adns8	571	6	are	be	VBP
cord-023168-cd7adns8	571	7	similar	similar	JJ
cord-023168-cd7adns8	571	8	to	to	IN
cord-023168-cd7adns8	571	9	those	those	DT
cord-023168-cd7adns8	571	10	of	of	IN
cord-023168-cd7adns8	571	11	HbSS	HbSS	NNP
cord-023168-cd7adns8	571	12	disease	disease	NN
cord-023168-cd7adns8	571	13	but	but	CC
cord-023168-cd7adns8	571	14	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	571	15	,	,	,
cord-023168-cd7adns8	571	16	splenic	splenic	JJ
cord-023168-cd7adns8	571	17	infarcts	infarct	NNS
cord-023168-cd7adns8	571	18	and	and	CC
cord-023168-cd7adns8	571	19	splenic	splenic	JJ
cord-023168-cd7adns8	571	20	sequestration	sequestration	NN
cord-023168-cd7adns8	571	21	may	may	MD
cord-023168-cd7adns8	571	22	occur	occur	VB
cord-023168-cd7adns8	571	23	into	into	IN
cord-023168-cd7adns8	571	24	adulthood	adulthood	NN
cord-023168-cd7adns8	571	25	.	.	.
cord-023168-cd7adns8	572	1	Proliferative	proliferative	JJ
cord-023168-cd7adns8	572	2	retinopathy	retinopathy	NN
cord-023168-cd7adns8	572	3	necessitates	necessitate	VBZ
cord-023168-cd7adns8	572	4	regular	regular	JJ
cord-023168-cd7adns8	572	5	ophthalmic	ophthalmic	JJ
cord-023168-cd7adns8	572	6	review	review	NN
cord-023168-cd7adns8	572	7	in	in	IN
cord-023168-cd7adns8	572	8	those	those	DT
cord-023168-cd7adns8	572	9	aged	age	VBN
cord-023168-cd7adns8	572	10	over	over	IN
cord-023168-cd7adns8	572	11	10	10	CD
cord-023168-cd7adns8	572	12	years	year	NNS
cord-023168-cd7adns8	572	13	.	.	.
cord-023168-cd7adns8	573	1	Compared	compare	VBN
cord-023168-cd7adns8	573	2	with	with	IN
cord-023168-cd7adns8	573	3	HbSS	HbSS	NNP
cord-023168-cd7adns8	573	4	,	,	,
cord-023168-cd7adns8	573	5	anaemia	anaemia	NN
cord-023168-cd7adns8	573	6	is	be	VBZ
cord-023168-cd7adns8	573	7	less	less	RBR
cord-023168-cd7adns8	573	8	marked	mark	VBN
cord-023168-cd7adns8	573	9	in	in	IN
cord-023168-cd7adns8	573	10	Hb	Hb	NNP
cord-023168-cd7adns8	573	11	SC	SC	NNP
cord-023168-cd7adns8	573	12	(	(	-LRB-
cord-023168-cd7adns8	573	13	8	8	CD
cord-023168-cd7adns8	573	14	-	-	SYM
cord-023168-cd7adns8	573	15	140	140	CD
cord-023168-cd7adns8	573	16	g	g	NN
cord-023168-cd7adns8	573	17	/	/	SYM
cord-023168-cd7adns8	573	18	L	L	NNP
cord-023168-cd7adns8	573	19	)	)	-RRB-
cord-023168-cd7adns8	573	20	and	and	CC
cord-023168-cd7adns8	573	21	there	there	EX
cord-023168-cd7adns8	573	22	are	be	VBP
cord-023168-cd7adns8	573	23	fewer	few	JJR
cord-023168-cd7adns8	573	24	sickle	sickle	NN
cord-023168-cd7adns8	573	25	cells	cell	NNS
cord-023168-cd7adns8	573	26	and	and	CC
cord-023168-cd7adns8	573	27	more	more	JJR
cord-023168-cd7adns8	573	28	target	target	NN
cord-023168-cd7adns8	573	29	cells	cell	NNS
cord-023168-cd7adns8	573	30	on	on	IN
cord-023168-cd7adns8	573	31	the	the	DT
cord-023168-cd7adns8	573	32	blood	blood	NN
cord-023168-cd7adns8	573	33	film	film	NN
cord-023168-cd7adns8	573	34	.	.	.
cord-023168-cd7adns8	574	1	The	the	DT
cord-023168-cd7adns8	574	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	574	3	can	can	MD
cord-023168-cd7adns8	574	4	be	be	VB
cord-023168-cd7adns8	574	5	confirmed	confirm	VBN
cord-023168-cd7adns8	574	6	by	by	IN
cord-023168-cd7adns8	574	7	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	574	8	electrophoresis	electrophoresis	NN
cord-023168-cd7adns8	574	9	,	,	,
cord-023168-cd7adns8	574	10	HPLC	HPLC	NNP
cord-023168-cd7adns8	574	11	or	or	CC
cord-023168-cd7adns8	574	12	iso	iso	JJ
cord-023168-cd7adns8	574	13	-	-	HYPH
cord-023168-cd7adns8	574	14	electric	electric	JJ
cord-023168-cd7adns8	574	15	focussing	focussing	NN
cord-023168-cd7adns8	574	16	.	.	.
cord-023168-cd7adns8	575	1	worsening	worsen	VBG
cord-023168-cd7adns8	575	2	of	of	IN
cord-023168-cd7adns8	575	3	complications	complication	NNS
cord-023168-cd7adns8	575	4	.	.	.
cord-023168-cd7adns8	576	1	In	in	IN
cord-023168-cd7adns8	576	2	exchange	exchange	NN
cord-023168-cd7adns8	576	3	transfusion	transfusion	NN
cord-023168-cd7adns8	576	4	,	,	,
cord-023168-cd7adns8	576	5	the	the	DT
cord-023168-cd7adns8	576	6	aim	aim	NN
cord-023168-cd7adns8	576	7	is	be	VBZ
cord-023168-cd7adns8	576	8	to	to	TO
cord-023168-cd7adns8	576	9	achieve	achieve	VB
cord-023168-cd7adns8	576	10	an	an	DT
cord-023168-cd7adns8	576	11	HbS%	hbs%	NN
cord-023168-cd7adns8	576	12	of	of	IN
cord-023168-cd7adns8	576	13	<	<	NNP
cord-023168-cd7adns8	576	14	30	30	CD
cord-023168-cd7adns8	576	15	%	%	NN
cord-023168-cd7adns8	576	16	.	.	.
cord-023168-cd7adns8	577	1	Complications	complication	NNS
cord-023168-cd7adns8	577	2	of	of	IN
cord-023168-cd7adns8	577	3	transfusion	transfusion	NN
cord-023168-cd7adns8	577	4	in	in	IN
cord-023168-cd7adns8	577	5	SCD	SCD	NNP
cord-023168-cd7adns8	577	6	include	include	VBP
cord-023168-cd7adns8	577	7	alloimmunization	alloimmunization	NN
cord-023168-cd7adns8	577	8	,	,	,
cord-023168-cd7adns8	577	9	114	114	CD
cord-023168-cd7adns8	577	10	delayed	delay	VBN
cord-023168-cd7adns8	577	11	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	577	12	transfusion	transfusion	NN
cord-023168-cd7adns8	577	13	reactions	reaction	NNS
cord-023168-cd7adns8	577	14	and	and	CC
cord-023168-cd7adns8	577	15	iron	iron	NN
cord-023168-cd7adns8	577	16	overload	overload	NN
cord-023168-cd7adns8	577	17	.	.	.
cord-023168-cd7adns8	578	1	The	the	DT
cord-023168-cd7adns8	578	2	high	high	JJ
cord-023168-cd7adns8	578	3	rates	rate	NNS
cord-023168-cd7adns8	578	4	of	of	IN
cord-023168-cd7adns8	578	5	red	red	JJ
cord-023168-cd7adns8	578	6	cell	cell	NN
cord-023168-cd7adns8	578	7	antibody	antibody	NN
cord-023168-cd7adns8	578	8	formation	formation	NN
cord-023168-cd7adns8	578	9	(	(	-LRB-
cord-023168-cd7adns8	578	10	30	30	CD
cord-023168-cd7adns8	578	11	%	%	NN
cord-023168-cd7adns8	578	12	)	)	-RRB-
cord-023168-cd7adns8	578	13	noted	note	VBN
cord-023168-cd7adns8	578	14	in	in	IN
cord-023168-cd7adns8	578	15	wealthy	wealthy	JJ
cord-023168-cd7adns8	578	16	countries	country	NNS
cord-023168-cd7adns8	578	17	are	be	VBP
cord-023168-cd7adns8	578	18	due	due	JJ
cord-023168-cd7adns8	578	19	to	to	IN
cord-023168-cd7adns8	578	20	minor	minor	JJ
cord-023168-cd7adns8	578	21	blood	blood	NN
cord-023168-cd7adns8	578	22	group	group	NN
cord-023168-cd7adns8	578	23	incompatibilities	incompatibility	NNS
cord-023168-cd7adns8	578	24	between	between	IN
cord-023168-cd7adns8	578	25	the	the	DT
cord-023168-cd7adns8	578	26	recipient	recipient	NN
cord-023168-cd7adns8	578	27	and	and	CC
cord-023168-cd7adns8	578	28	the	the	DT
cord-023168-cd7adns8	578	29	blood	blood	NN
cord-023168-cd7adns8	578	30	donor	donor	NN
cord-023168-cd7adns8	578	31	who	who	WP
cord-023168-cd7adns8	578	32	is	be	VBZ
cord-023168-cd7adns8	578	33	often	often	RB
cord-023168-cd7adns8	578	34	of	of	IN
cord-023168-cd7adns8	578	35	a	a	DT
cord-023168-cd7adns8	578	36	different	different	JJ
cord-023168-cd7adns8	578	37	ethnicity	ethnicity	NN
cord-023168-cd7adns8	578	38	.	.	.
cord-023168-cd7adns8	579	1	Leukocyte	Leukocyte	NNP
cord-023168-cd7adns8	579	2	reduction	reduction	NN
cord-023168-cd7adns8	579	3	of	of	IN
cord-023168-cd7adns8	579	4	transfused	transfuse	VBN
cord-023168-cd7adns8	579	5	blood	blood	NN
cord-023168-cd7adns8	579	6	,	,	,
cord-023168-cd7adns8	579	7	routine	routine	JJ
cord-023168-cd7adns8	579	8	ABO	ABO	NNP
cord-023168-cd7adns8	579	9	,	,	,
cord-023168-cd7adns8	579	10	Rh	Rh	NNP
cord-023168-cd7adns8	579	11	and	and	CC
cord-023168-cd7adns8	579	12	Kell	Kell	NNP
cord-023168-cd7adns8	579	13	matching	match	VBG
cord-023168-cd7adns8	579	14	for	for	IN
cord-023168-cd7adns8	579	15	all	all	DT
cord-023168-cd7adns8	579	16	patients	patient	NNS
cord-023168-cd7adns8	579	17	and	and	CC
cord-023168-cd7adns8	579	18	extended	extended	JJ
cord-023168-cd7adns8	579	19	phenotype	phenotype	NN
cord-023168-cd7adns8	579	20	matching	match	VBG
cord-023168-cd7adns8	579	21	for	for	IN
cord-023168-cd7adns8	579	22	those	those	DT
cord-023168-cd7adns8	579	23	with	with	IN
cord-023168-cd7adns8	579	24	alloantibodies	alloantibody	NNS
cord-023168-cd7adns8	579	25	may	may	MD
cord-023168-cd7adns8	579	26	be	be	VB
cord-023168-cd7adns8	579	27	useful	useful	JJ
cord-023168-cd7adns8	579	28	for	for	IN
cord-023168-cd7adns8	579	29	reducing	reduce	VBG
cord-023168-cd7adns8	579	30	transfusion	transfusion	NN
cord-023168-cd7adns8	579	31	reactions	reaction	NNS
cord-023168-cd7adns8	579	32	.	.	.
cord-023168-cd7adns8	580	1	Treatment	treatment	NN
cord-023168-cd7adns8	580	2	for	for	IN
cord-023168-cd7adns8	580	3	ACS	ACS	NNP
cord-023168-cd7adns8	580	4	is	be	VBZ
cord-023168-cd7adns8	580	5	predominantly	predominantly	RB
cord-023168-cd7adns8	580	6	supportive	supportive	JJ
cord-023168-cd7adns8	580	7	and	and	CC
cord-023168-cd7adns8	580	8	includes	include	VBZ
cord-023168-cd7adns8	580	9	adequate	adequate	JJ
cord-023168-cd7adns8	580	10	pain	pain	NN
cord-023168-cd7adns8	580	11	relief	relief	NN
cord-023168-cd7adns8	580	12	,	,	,
cord-023168-cd7adns8	580	13	antibiotics	antibiotic	NNS
cord-023168-cd7adns8	580	14	(	(	-LRB-
cord-023168-cd7adns8	580	15	e.g.	e.g.	RB
cord-023168-cd7adns8	580	16	a	a	DT
cord-023168-cd7adns8	580	17	macrolide	macrolide	NN
cord-023168-cd7adns8	580	18	with	with	IN
cord-023168-cd7adns8	580	19	a	a	DT
cord-023168-cd7adns8	580	20	cephalosporin	cephalosporin	NN
cord-023168-cd7adns8	580	21	)	)	-RRB-
cord-023168-cd7adns8	580	22	,	,	,
cord-023168-cd7adns8	580	23	continuous	continuous	JJ
cord-023168-cd7adns8	580	24	pulse	pulse	NN
cord-023168-cd7adns8	580	25	oximetry	oximetry	NN
cord-023168-cd7adns8	580	26	and	and	CC
cord-023168-cd7adns8	580	27	delivery	delivery	NN
cord-023168-cd7adns8	580	28	of	of	IN
cord-023168-cd7adns8	580	29	supplemental	supplemental	JJ
cord-023168-cd7adns8	580	30	oxygen	oxygen	NN
cord-023168-cd7adns8	580	31	to	to	IN
cord-023168-cd7adns8	580	32	patients	patient	NNS
cord-023168-cd7adns8	580	33	with	with	IN
cord-023168-cd7adns8	580	34	hypoxaemia	hypoxaemia	NNP
cord-023168-cd7adns8	580	35	.	.	.
cord-023168-cd7adns8	581	1	Incentive	incentive	JJ
cord-023168-cd7adns8	581	2	spirometry	spirometry	NN
cord-023168-cd7adns8	581	3	can	can	MD
cord-023168-cd7adns8	581	4	prevent	prevent	VB
cord-023168-cd7adns8	581	5	atelectasis	atelectasis	NN
cord-023168-cd7adns8	581	6	and	and	CC
cord-023168-cd7adns8	581	7	infiltrates	infiltrate	VBZ
cord-023168-cd7adns8	581	8	115	115	CD
cord-023168-cd7adns8	581	9	and	and	CC
cord-023168-cd7adns8	581	10	blood	blood	NN
cord-023168-cd7adns8	581	11	transfusion	transfusion	NN
cord-023168-cd7adns8	581	12	is	be	VBZ
cord-023168-cd7adns8	581	13	indicated	indicate	VBN
cord-023168-cd7adns8	581	14	when	when	WRB
cord-023168-cd7adns8	581	15	a	a	DT
cord-023168-cd7adns8	581	16	patient	patient	NN
cord-023168-cd7adns8	581	17	develops	develop	VBZ
cord-023168-cd7adns8	581	18	respiratory	respiratory	JJ
cord-023168-cd7adns8	581	19	distress	distress	NN
cord-023168-cd7adns8	581	20	,	,	,
cord-023168-cd7adns8	581	21	a	a	DT
cord-023168-cd7adns8	581	22	clinically	clinically	RB
cord-023168-cd7adns8	581	23	significant	significant	JJ
cord-023168-cd7adns8	581	24	fall	fall	NN
cord-023168-cd7adns8	581	25	in	in	IN
cord-023168-cd7adns8	581	26	the	the	DT
cord-023168-cd7adns8	581	27	haematocrit	haematocrit	NNP
cord-023168-cd7adns8	581	28	or	or	CC
cord-023168-cd7adns8	581	29	signs	sign	NNS
cord-023168-cd7adns8	582	1	The	the	DT
cord-023168-cd7adns8	582	2	following	follow	VBG
cord-023168-cd7adns8	582	3	predict	predict	VBP
cord-023168-cd7adns8	582	4	a	a	DT
cord-023168-cd7adns8	582	5	more	more	RBR
cord-023168-cd7adns8	582	6	severe	severe	JJ
cord-023168-cd7adns8	582	7	clinical	clinical	JJ
cord-023168-cd7adns8	582	8	course	course	NN
cord-023168-cd7adns8	582	9	and	and	CC
cord-023168-cd7adns8	582	10	are	be	VBP
cord-023168-cd7adns8	582	11	additional	additional	JJ
cord-023168-cd7adns8	582	12	reasons	reason	NNS
cord-023168-cd7adns8	582	13	to	to	TO
cord-023168-cd7adns8	582	14	consider	consider	VB
cord-023168-cd7adns8	582	15	offering	offer	VBG
cord-023168-cd7adns8	582	16	hydroxyurea	hydroxyurea	NN
cord-023168-cd7adns8	582	17	:	:	:
cord-023168-cd7adns8	583	1	Hb	Hb	NNP
cord-023168-cd7adns8	583	2	<	<	XX
cord-023168-cd7adns8	583	3	70	70	CD
cord-023168-cd7adns8	583	4	g	g	NN
cord-023168-cd7adns8	583	5	/	/	SYM
cord-023168-cd7adns8	583	6	L	L	NNP
cord-023168-cd7adns8	583	7	,	,	,
cord-023168-cd7adns8	583	8	WBC	WBC	NNP
cord-023168-cd7adns8	583	9	>	>	XX
cord-023168-cd7adns8	584	1	15	15	CD
cord-023168-cd7adns8	584	2	×	×	NN
cord-023168-cd7adns8	584	3	10	10	CD
cord-023168-cd7adns8	584	4	9	9	CD
cord-023168-cd7adns8	584	5	/L	/l	CD
cord-023168-cd7adns8	584	6	,	,	,
cord-023168-cd7adns8	584	7	HbF	HbF	NNP
cord-023168-cd7adns8	584	8	<	<	XX
cord-023168-cd7adns8	584	9	6	6	CD
cord-023168-cd7adns8	584	10	%	%	NN
cord-023168-cd7adns8	584	11	and	and	CC
cord-023168-cd7adns8	584	12	renal	renal	JJ
cord-023168-cd7adns8	584	13	insufficiency	insufficiency	NN
cord-023168-cd7adns8	584	14	due	due	IN
cord-023168-cd7adns8	584	15	to	to	IN
cord-023168-cd7adns8	584	16	SCD	SCD	NNP
cord-023168-cd7adns8	584	17	.	.	.
cord-023168-cd7adns8	585	1	•	•	NNP
cord-023168-cd7adns8	585	2	Start	start	VB
cord-023168-cd7adns8	585	3	at	at	IN
cord-023168-cd7adns8	585	4	10	10	CD
cord-023168-cd7adns8	585	5	-	-	SYM
cord-023168-cd7adns8	585	6	15	15	CD
cord-023168-cd7adns8	585	7	mg	mg	NNP
cord-023168-cd7adns8	585	8	/	/	SYM
cord-023168-cd7adns8	585	9	kg	kg	NN
cord-023168-cd7adns8	585	10	per	per	IN
cord-023168-cd7adns8	585	11	day	day	NN
cord-023168-cd7adns8	585	12	(	(	-LRB-
cord-023168-cd7adns8	585	13	to	to	IN
cord-023168-cd7adns8	585	14	the	the	DT
cord-023168-cd7adns8	585	15	nearest	near	JJS
cord-023168-cd7adns8	585	16	500	500	CD
cord-023168-cd7adns8	585	17	mg	mg	NNP
cord-023168-cd7adns8	585	18	/	/	SYM
cord-023168-cd7adns8	585	19	day	day	NN
cord-023168-cd7adns8	585	20	)	)	-RRB-
cord-023168-cd7adns8	586	1	•	•	NNP
cord-023168-cd7adns8	587	1	If	if	IN
cord-023168-cd7adns8	587	2	no	no	DT
cord-023168-cd7adns8	587	3	or	or	CC
cord-023168-cd7adns8	587	4	poor	poor	JJ
cord-023168-cd7adns8	587	5	response	response	NN
cord-023168-cd7adns8	587	6	,	,	,
cord-023168-cd7adns8	587	7	increase	increase	VB
cord-023168-cd7adns8	587	8	dose	dose	NN
cord-023168-cd7adns8	587	9	by	by	IN
cord-023168-cd7adns8	587	10	increments	increment	NNS
cord-023168-cd7adns8	587	11	of	of	IN
cord-023168-cd7adns8	587	12	5	5	CD
cord-023168-cd7adns8	587	13	mg/	mg/	NN
cord-023168-cd7adns8	587	14	kg	kg	NN
cord-023168-cd7adns8	587	15	per	per	IN
cord-023168-cd7adns8	587	16	day	day	NN
cord-023168-cd7adns8	587	17	every	every	DT
cord-023168-cd7adns8	587	18	4	4	CD
cord-023168-cd7adns8	587	19	weeks	week	NNS
cord-023168-cd7adns8	588	1	(	(	-LRB-
cord-023168-cd7adns8	588	2	max	max	NNP
cord-023168-cd7adns8	588	3	:	:	:
cord-023168-cd7adns8	588	4	30	30	CD
cord-023168-cd7adns8	588	5	mg	mg	NN
cord-023168-cd7adns8	588	6	/	/	SYM
cord-023168-cd7adns8	588	7	kg	kg	NN
cord-023168-cd7adns8	588	8	per	per	IN
cord-023168-cd7adns8	588	9	day	day	NN
cord-023168-cd7adns8	588	10	)	)	-RRB-
cord-023168-cd7adns8	588	11	.	.	.
cord-023168-cd7adns8	589	1	Most	Most	JJS
cord-023168-cd7adns8	589	2	good	good	JJ
cord-023168-cd7adns8	589	3	responses	response	NNS
cord-023168-cd7adns8	589	4	require	require	VBP
cord-023168-cd7adns8	589	5	about	about	IN
cord-023168-cd7adns8	589	6	1	1	CD
cord-023168-cd7adns8	589	7	-	-	SYM
cord-023168-cd7adns8	589	8	2	2	CD
cord-023168-cd7adns8	589	9	g	g	NN
cord-023168-cd7adns8	589	10	/	/	SYM
cord-023168-cd7adns8	589	11	day	day	NN
cord-023168-cd7adns8	589	12	in	in	IN
cord-023168-cd7adns8	589	13	adults	adult	NNS
cord-023168-cd7adns8	590	1	•	•	NNP
cord-023168-cd7adns8	590	2	Monitor	Monitor	NNP
cord-023168-cd7adns8	590	3	FBC	FBC	NNP
cord-023168-cd7adns8	590	4	,	,	,
cord-023168-cd7adns8	590	5	HbF%	HbF%	NNP
cord-023168-cd7adns8	590	6	,	,	,
cord-023168-cd7adns8	590	7	and	and	CC
cord-023168-cd7adns8	590	8	reticulocytes	reticulocytes	NNPS
cord-023168-cd7adns8	590	9	every	every	DT
cord-023168-cd7adns8	590	10	1	1	CD
cord-023168-cd7adns8	590	11	or	or	CC
cord-023168-cd7adns8	590	12	2	2	CD
cord-023168-cd7adns8	590	13	weeks	week	NNS
cord-023168-cd7adns8	590	14	initially	initially	RB
cord-023168-cd7adns8	590	15	,	,	,
cord-023168-cd7adns8	590	16	then	then	RB
cord-023168-cd7adns8	590	17	every	every	DT
cord-023168-cd7adns8	590	18	4	4	CD
cord-023168-cd7adns8	590	19	weeks	week	NNS
cord-023168-cd7adns8	590	20	when	when	WRB
cord-023168-cd7adns8	590	21	on	on	IN
cord-023168-cd7adns8	590	22	a	a	DT
cord-023168-cd7adns8	590	23	stable	stable	JJ
cord-023168-cd7adns8	590	24	dose	dose	NN
cord-023168-cd7adns8	591	1	•	•	NNP
cord-023168-cd7adns8	591	2	Monitor	monitor	VB
cord-023168-cd7adns8	591	3	biochemistry	biochemistry	NN
cord-023168-cd7adns8	591	4	profile	profile	NN
cord-023168-cd7adns8	592	1	(	(	-LRB-
cord-023168-cd7adns8	592	2	hydroxyurea	hydroxyurea	NNP
cord-023168-cd7adns8	592	3	has	have	VBZ
cord-023168-cd7adns8	592	4	renal	renal	JJ
cord-023168-cd7adns8	592	5	excretion	excretion	NN
cord-023168-cd7adns8	592	6	and	and	CC
cord-023168-cd7adns8	592	7	hepatic	hepatic	JJ
cord-023168-cd7adns8	592	8	toxicity	toxicity	NN
cord-023168-cd7adns8	592	9	)	)	-RRB-
cord-023168-cd7adns8	592	10	.	.	.
cord-023168-cd7adns8	593	1	•	•	NNP
cord-023168-cd7adns8	594	1	Less	Less	JJR
cord-023168-cd7adns8	594	2	pain	pain	NN
cord-023168-cd7adns8	595	1	•	•	NNP
cord-023168-cd7adns8	596	1	Persistent	persistent	JJ
cord-023168-cd7adns8	596	2	increase	increase	NN
cord-023168-cd7adns8	596	3	in	in	IN
cord-023168-cd7adns8	596	4	HbF	HbF	NNP
cord-023168-cd7adns8	596	5	(	(	-LRB-
cord-023168-cd7adns8	596	6	usually	usually	RB
cord-023168-cd7adns8	596	7	measured	measure	VBN
cord-023168-cd7adns8	596	8	every	every	DT
cord-023168-cd7adns8	596	9	6	6	CD
cord-023168-cd7adns8	596	10	-	-	SYM
cord-023168-cd7adns8	596	11	8	8	CD
cord-023168-cd7adns8	596	12	weeks	week	NNS
cord-023168-cd7adns8	596	13	)	)	-RRB-
cord-023168-cd7adns8	596	14	or	or	CC
cord-023168-cd7adns8	596	15	mean	mean	VB
cord-023168-cd7adns8	596	16	cell	cell	NN
cord-023168-cd7adns8	596	17	volume	volume	NN
cord-023168-cd7adns8	597	1	•	•	NNP
cord-023168-cd7adns8	598	1	Persistent	persistent	JJ
cord-023168-cd7adns8	598	2	increase	increase	NN
cord-023168-cd7adns8	598	3	in	in	IN
cord-023168-cd7adns8	598	4	haematocrit	haematocrit	NNP
cord-023168-cd7adns8	598	5	if	if	IN
cord-023168-cd7adns8	598	6	severely	severely	RB
cord-023168-cd7adns8	598	7	anaemic	anaemic	JJ
cord-023168-cd7adns8	599	1	•	•	NNP
cord-023168-cd7adns8	600	1	Decrease	decrease	VB
cord-023168-cd7adns8	600	2	in	in	IN
cord-023168-cd7adns8	600	3	LDH	LDH	NNP
cord-023168-cd7adns8	601	1	•	•	NNP
cord-023168-cd7adns8	602	1	Acceptable	acceptable	JJ
cord-023168-cd7adns8	602	2	toxicity	toxicity	NN
cord-023168-cd7adns8	602	3	.	.	.
cord-023168-cd7adns8	603	1	Improvement	improvement	NN
cord-023168-cd7adns8	603	2	in	in	IN
cord-023168-cd7adns8	603	3	symptoms	symptom	NNS
cord-023168-cd7adns8	603	4	and	and	CC
cord-023168-cd7adns8	603	5	blood	blood	NN
cord-023168-cd7adns8	603	6	parameters	parameter	NNS
cord-023168-cd7adns8	603	7	may	may	MD
cord-023168-cd7adns8	603	8	take	take	VB
cord-023168-cd7adns8	603	9	3	3	CD
cord-023168-cd7adns8	603	10	-	-	SYM
cord-023168-cd7adns8	603	11	4	4	CD
cord-023168-cd7adns8	603	12	months	month	NNS
cord-023168-cd7adns8	603	13	of	of	IN
cord-023168-cd7adns8	603	14	therapy	therapy	NN
cord-023168-cd7adns8	603	15	,	,	,
cord-023168-cd7adns8	603	16	but	but	CC
cord-023168-cd7adns8	603	17	can	can	MD
cord-023168-cd7adns8	603	18	be	be	VB
cord-023168-cd7adns8	603	19	seen	see	VBN
cord-023168-cd7adns8	603	20	after	after	IN
cord-023168-cd7adns8	603	21	approximately	approximately	RB
cord-023168-cd7adns8	603	22	6	6	CD
cord-023168-cd7adns8	603	23	weeks	week	NNS
cord-023168-cd7adns8	603	24	.	.	.
cord-023168-cd7adns8	604	1	If	if	IN
cord-023168-cd7adns8	604	2	the	the	DT
cord-023168-cd7adns8	604	3	reticulocyte	reticulocyte	NNP
cord-023168-cd7adns8	604	4	count	count	NN
cord-023168-cd7adns8	604	5	is	be	VBZ
cord-023168-cd7adns8	604	6	less	less	JJR
cord-023168-cd7adns8	604	7	than	than	IN
cord-023168-cd7adns8	604	8	expected	expect	VBN
cord-023168-cd7adns8	604	9	for	for	IN
cord-023168-cd7adns8	604	10	the	the	DT
cord-023168-cd7adns8	604	11	degree	degree	NN
cord-023168-cd7adns8	604	12	of	of	IN
cord-023168-cd7adns8	604	13	anaemia	anaemia	NN
cord-023168-cd7adns8	604	14	,	,	,
cord-023168-cd7adns8	604	15	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	604	16	deficiency	deficiency	NN
cord-023168-cd7adns8	604	17	should	should	MD
cord-023168-cd7adns8	604	18	be	be	VB
cord-023168-cd7adns8	604	19	considered	consider	VBN
cord-023168-cd7adns8	604	20	.	.	.
cord-023168-cd7adns8	604	21	 	 	_SP
cord-023168-cd7adns8	605	1	•	•	NNP
cord-023168-cd7adns8	606	1	Aim	aim	VB
cord-023168-cd7adns8	606	2	in	in	IN
cord-023168-cd7adns8	606	3	all	all	DT
cord-023168-cd7adns8	606	4	cases	case	NNS
cord-023168-cd7adns8	606	5	to	to	TO
cord-023168-cd7adns8	606	6	reduce	reduce	VB
cord-023168-cd7adns8	606	7	HbS	hbs	JJ
cord-023168-cd7adns8	606	8	level	level	NN
cord-023168-cd7adns8	606	9	to	to	IN
cord-023168-cd7adns8	606	10	<	<	XX
cord-023168-cd7adns8	606	11	30	30	CD
cord-023168-cd7adns8	606	12	%	%	NN
cord-023168-cd7adns8	607	1	•	•	NNP
cord-023168-cd7adns8	608	1	Exchange	exchange	NN
cord-023168-cd7adns8	608	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	608	3	may	may	MD
cord-023168-cd7adns8	608	4	be	be	VB
cord-023168-cd7adns8	608	5	considered	consider	VBN
cord-023168-cd7adns8	608	6	in	in	IN
cord-023168-cd7adns8	608	7	cases	case	NNS
cord-023168-cd7adns8	608	8	of	of	IN
cord-023168-cd7adns8	608	9	stroke	stroke	NN
cord-023168-cd7adns8	608	10	,	,	,
cord-023168-cd7adns8	608	11	acute	acute	JJ
cord-023168-cd7adns8	608	12	chest	chest	NN
cord-023168-cd7adns8	608	13	syndrome	syndrome	NN
cord-023168-cd7adns8	608	14	not	not	RB
cord-023168-cd7adns8	608	15	responding	respond	VBG
cord-023168-cd7adns8	608	16	to	to	IN
cord-023168-cd7adns8	608	17	top	top	JJ
cord-023168-cd7adns8	608	18	-	-	HYPH
cord-023168-cd7adns8	608	19	up	up	RP
cord-023168-cd7adns8	608	20	transfusion	transfusion	NN
cord-023168-cd7adns8	608	21	and	and	CC
cord-023168-cd7adns8	608	22	major	major	JJ
cord-023168-cd7adns8	608	23	surgeries	surgery	NNS
cord-023168-cd7adns8	609	1	•	•	NNP
cord-023168-cd7adns8	610	1	Target	target	VB
cord-023168-cd7adns8	610	2	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	610	3	concentration	concentration	NN
cord-023168-cd7adns8	610	4	of	of	IN
cord-023168-cd7adns8	610	5	100	100	CD
cord-023168-cd7adns8	610	6	g	g	NN
cord-023168-cd7adns8	610	7	/	/	SYM
cord-023168-cd7adns8	610	8	L	L	NNP
cord-023168-cd7adns8	610	9	may	may	MD
cord-023168-cd7adns8	610	10	be	be	VB
cord-023168-cd7adns8	610	11	considered	consider	VBN
cord-023168-cd7adns8	610	12	in	in	IN
cord-023168-cd7adns8	610	13	cases	case	NNS
cord-023168-cd7adns8	610	14	of	of	IN
cord-023168-cd7adns8	610	15	organ	organ	NN
cord-023168-cd7adns8	610	16	failure	failure	NN
cord-023168-cd7adns8	610	17	and	and	CC
cord-023168-cd7adns8	610	18	surgery	surgery	NN
cord-023168-cd7adns8	610	19	.	.	.
cord-023168-cd7adns8	611	1	Individuals	individual	NNS
cord-023168-cd7adns8	611	2	with	with	IN
cord-023168-cd7adns8	611	3	sickle	sickle	NN
cord-023168-cd7adns8	611	4	cell	cell	NN
cord-023168-cd7adns8	611	5	trait	trait	NN
cord-023168-cd7adns8	611	6	(	(	-LRB-
cord-023168-cd7adns8	611	7	Hb	Hb	NNP
cord-023168-cd7adns8	611	8	AS	AS	NNP
cord-023168-cd7adns8	611	9	)	)	-RRB-
cord-023168-cd7adns8	611	10	have	have	VB
cord-023168-cd7adns8	611	11	10-fold	10-fold	JJ
cord-023168-cd7adns8	611	12	protection	protection	NN
cord-023168-cd7adns8	611	13	against	against	IN
cord-023168-cd7adns8	611	14	severe	severe	JJ
cord-023168-cd7adns8	611	15	malaria	malaria	NN
cord-023168-cd7adns8	611	16	compared	compare	VBN
cord-023168-cd7adns8	611	17	to	to	IN
cord-023168-cd7adns8	611	18	individuals	individual	NNS
cord-023168-cd7adns8	611	19	with	with	IN
cord-023168-cd7adns8	611	20	normal	normal	JJ
cord-023168-cd7adns8	611	21	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	611	22	(	(	-LRB-
cord-023168-cd7adns8	611	23	HbAA	HbAA	NNP
cord-023168-cd7adns8	611	24	)	)	-RRB-
cord-023168-cd7adns8	611	25	probably	probably	RB
cord-023168-cd7adns8	611	26	due	due	JJ
cord-023168-cd7adns8	611	27	to	to	IN
cord-023168-cd7adns8	611	28	both	both	DT
cord-023168-cd7adns8	611	29	innate	innate	JJ
cord-023168-cd7adns8	611	30	and	and	CC
cord-023168-cd7adns8	611	31	immune	immune	JJ
cord-023168-cd7adns8	611	32	-	-	HYPH
cord-023168-cd7adns8	611	33	mediated	mediate	VBN
cord-023168-cd7adns8	611	34	mechanisms	mechanism	NNS
cord-023168-cd7adns8	611	35	.	.	.
cord-023168-cd7adns8	612	1	Individuals	individual	NNS
cord-023168-cd7adns8	612	2	with	with	IN
cord-023168-cd7adns8	612	3	sickle	sickle	NN
cord-023168-cd7adns8	612	4	cell	cell	NN
cord-023168-cd7adns8	612	5	trait	trait	NN
cord-023168-cd7adns8	612	6	(	(	-LRB-
cord-023168-cd7adns8	612	7	HbAS	HbAS	NNP
cord-023168-cd7adns8	612	8	)	)	-RRB-
cord-023168-cd7adns8	612	9	are	be	VBP
cord-023168-cd7adns8	612	10	generally	generally	RB
cord-023168-cd7adns8	612	11	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	612	12	and	and	CC
cord-023168-cd7adns8	612	13	they	-PRON-	PRP
cord-023168-cd7adns8	612	14	have	have	VBP
cord-023168-cd7adns8	612	15	a	a	DT
cord-023168-cd7adns8	612	16	normal	normal	JJ
cord-023168-cd7adns8	612	17	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	612	18	and	and	CC
cord-023168-cd7adns8	612	19	normal	normal	JJ
cord-023168-cd7adns8	612	20	life	life	NN
cord-023168-cd7adns8	612	21	expectancy	expectancy	NN
cord-023168-cd7adns8	612	22	.	.	.
cord-023168-cd7adns8	613	1	Uncommonly	uncommonly	RB
cord-023168-cd7adns8	613	2	,	,	,
cord-023168-cd7adns8	613	3	complications	complication	NNS
cord-023168-cd7adns8	613	4	such	such	JJ
cord-023168-cd7adns8	613	5	as	as	IN
cord-023168-cd7adns8	613	6	poor	poor	JJ
cord-023168-cd7adns8	613	7	perfusion	perfusion	NN
cord-023168-cd7adns8	613	8	of	of	IN
cord-023168-cd7adns8	613	9	the	the	DT
cord-023168-cd7adns8	613	10	renal	renal	JJ
cord-023168-cd7adns8	613	11	papillae	papilla	NNS
cord-023168-cd7adns8	613	12	and	and	CC
cord-023168-cd7adns8	613	13	increased	increase	VBN
cord-023168-cd7adns8	613	14	bacteruria	bacteruria	NNP
cord-023168-cd7adns8	613	15	may	may	MD
cord-023168-cd7adns8	613	16	occur	occur	VB
cord-023168-cd7adns8	613	17	.	.	.
cord-023168-cd7adns8	614	1	124	124	CD
cord-023168-cd7adns8	615	1	The	the	DT
cord-023168-cd7adns8	615	2	blood	blood	NN
cord-023168-cd7adns8	615	3	film	film	NN
cord-023168-cd7adns8	615	4	is	be	VBZ
cord-023168-cd7adns8	615	5	generally	generally	RB
cord-023168-cd7adns8	615	6	normal	normal	JJ
cord-023168-cd7adns8	615	7	and	and	CC
cord-023168-cd7adns8	615	8	the	the	DT
cord-023168-cd7adns8	615	9	diagnosis	diagnosis	NN
cord-023168-cd7adns8	615	10	can	can	MD
cord-023168-cd7adns8	615	11	be	be	VB
cord-023168-cd7adns8	615	12	confirmed	confirm	VBN
cord-023168-cd7adns8	615	13	by	by	IN
cord-023168-cd7adns8	615	14	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	615	15	electrophoresis	electrophoresis	NN
cord-023168-cd7adns8	615	16	,	,	,
cord-023168-cd7adns8	615	17	HPLC	HPLC	NNP
cord-023168-cd7adns8	615	18	or	or	CC
cord-023168-cd7adns8	615	19	iso	iso	JJ
cord-023168-cd7adns8	615	20	-	-	HYPH
cord-023168-cd7adns8	615	21	electric	electric	JJ
cord-023168-cd7adns8	615	22	focusing	focusing	NN
cord-023168-cd7adns8	615	23	.	.	.
cord-023168-cd7adns8	616	1	The	the	DT
cord-023168-cd7adns8	616	2	original	original	JJ
cord-023168-cd7adns8	616	3	descriptions	description	NNS
cord-023168-cd7adns8	616	4	of	of	IN
cord-023168-cd7adns8	616	5	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	616	6	originated	originate	VBD
cord-023168-cd7adns8	616	7	from	from	IN
cord-023168-cd7adns8	616	8	areas	area	NNS
cord-023168-cd7adns8	616	9	round	round	IN
cord-023168-cd7adns8	616	10	the	the	DT
cord-023168-cd7adns8	616	11	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	616	12	and	and	CC
cord-023168-cd7adns8	616	13	the	the	DT
cord-023168-cd7adns8	616	14	term	term	NN
cord-023168-cd7adns8	616	15	derives	derive	VBZ
cord-023168-cd7adns8	616	16	from	from	IN
cord-023168-cd7adns8	616	17	the	the	DT
cord-023168-cd7adns8	616	18	Greek	greek	JJ
cord-023168-cd7adns8	616	19	thalassos	thalassos	NN
cord-023168-cd7adns8	616	20	(	(	-LRB-
cord-023168-cd7adns8	616	21	sea	sea	NN
cord-023168-cd7adns8	616	22	)	)	-RRB-
cord-023168-cd7adns8	616	23	and	and	CC
cord-023168-cd7adns8	616	24	haima	haima	NNP
cord-023168-cd7adns8	616	25	(	(	-LRB-
cord-023168-cd7adns8	616	26	blood	blood	NN
cord-023168-cd7adns8	616	27	)	)	-RRB-
cord-023168-cd7adns8	616	28	.	.	.
cord-023168-cd7adns8	617	1	[	[	-LRB-
cord-023168-cd7adns8	617	2	125	125	CD
cord-023168-cd7adns8	617	3	]	]	-RRB-
cord-023168-cd7adns8	617	4	[	[	-LRB-
cord-023168-cd7adns8	617	5	126	126	CD
cord-023168-cd7adns8	617	6	]	]	-RRB-
cord-023168-cd7adns8	617	7	[	[	-LRB-
cord-023168-cd7adns8	617	8	127	127	CD
cord-023168-cd7adns8	617	9	]	]	-RRB-
cord-023168-cd7adns8	617	10	EPIDEMIOLOGY	EPIDEMIOLOGY	NNP
cord-023168-cd7adns8	617	11	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	617	12	is	be	VBZ
cord-023168-cd7adns8	617	13	one	one	CD
cord-023168-cd7adns8	617	14	of	of	IN
cord-023168-cd7adns8	617	15	the	the	DT
cord-023168-cd7adns8	617	16	most	most	RBS
cord-023168-cd7adns8	617	17	common	common	JJ
cord-023168-cd7adns8	617	18	single	single	JJ
cord-023168-cd7adns8	617	19	gene	gene	NN
cord-023168-cd7adns8	617	20	disorders	disorder	NNS
cord-023168-cd7adns8	617	21	and	and	CC
cord-023168-cd7adns8	617	22	approximately	approximately	RB
cord-023168-cd7adns8	617	23	5	5	CD
cord-023168-cd7adns8	617	24	-	-	SYM
cord-023168-cd7adns8	617	25	7	7	CD
cord-023168-cd7adns8	617	26	%	%	NN
cord-023168-cd7adns8	617	27	of	of	IN
cord-023168-cd7adns8	617	28	the	the	DT
cord-023168-cd7adns8	617	29	global	global	JJ
cord-023168-cd7adns8	617	30	population	population	NN
cord-023168-cd7adns8	617	31	are	be	VBP
cord-023168-cd7adns8	617	32	carriers	carrier	NNS
cord-023168-cd7adns8	617	33	.	.	.
cord-023168-cd7adns8	618	1	α	α	NNP
cord-023168-cd7adns8	618	2	+	+	CC
cord-023168-cd7adns8	618	3	-Thalassaemia	-thalassaemia	NN
cord-023168-cd7adns8	618	4	occurs	occur	VBZ
cord-023168-cd7adns8	618	5	throughout	throughout	IN
cord-023168-cd7adns8	618	6	the	the	DT
cord-023168-cd7adns8	618	7	tropics	tropic	NNS
cord-023168-cd7adns8	618	8	,	,	,
cord-023168-cd7adns8	618	9	whereas	whereas	IN
cord-023168-cd7adns8	618	10	α	α	NNP
cord-023168-cd7adns8	618	11	0thalassaemia	0thalassaemia	CD
cord-023168-cd7adns8	618	12	,	,	,
cord-023168-cd7adns8	618	13	which	which	WDT
cord-023168-cd7adns8	618	14	is	be	VBZ
cord-023168-cd7adns8	618	15	responsible	responsible	JJ
cord-023168-cd7adns8	618	16	for	for	IN
cord-023168-cd7adns8	618	17	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	618	18	Bart	Bart	NNP
cord-023168-cd7adns8	618	19	's	's	POS
cord-023168-cd7adns8	618	20	hydrops	hydrops	NNP
cord-023168-cd7adns8	618	21	fetalis	fetalis	NNP
cord-023168-cd7adns8	618	22	,	,	,
cord-023168-cd7adns8	618	23	is	be	VBZ
cord-023168-cd7adns8	618	24	concentrated	concentrate	VBN
cord-023168-cd7adns8	618	25	predominantly	predominantly	RB
cord-023168-cd7adns8	618	26	in	in	IN
cord-023168-cd7adns8	618	27	South	South	NNP
cord-023168-cd7adns8	618	28	-	-	HYPH
cord-023168-cd7adns8	618	29	east	east	NN
cord-023168-cd7adns8	618	30	Asia	Asia	NNP
cord-023168-cd7adns8	618	31	and	and	CC
cord-023168-cd7adns8	618	32	to	to	IN
cord-023168-cd7adns8	618	33	a	a	DT
cord-023168-cd7adns8	618	34	lesser	less	JJR
cord-023168-cd7adns8	618	35	extent	extent	NN
cord-023168-cd7adns8	618	36	around	around	IN
cord-023168-cd7adns8	618	37	the	the	DT
cord-023168-cd7adns8	618	38	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	618	39	.	.	.
cord-023168-cd7adns8	619	1	128	128	CD
cord-023168-cd7adns8	619	2	,	,	,
cord-023168-cd7adns8	619	3	129	129	CD
cord-023168-cd7adns8	619	4	β	β	NN
cord-023168-cd7adns8	619	5	-	-	HYPH
cord-023168-cd7adns8	619	6	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	619	7	is	be	VBZ
cord-023168-cd7adns8	619	8	common	common	JJ
cord-023168-cd7adns8	619	9	in	in	IN
cord-023168-cd7adns8	619	10	the	the	DT
cord-023168-cd7adns8	619	11	Mediterranean	mediterranean	JJ
cord-023168-cd7adns8	619	12	countries	country	NNS
cord-023168-cd7adns8	619	13	,	,	,
cord-023168-cd7adns8	619	14	parts	part	NNS
cord-023168-cd7adns8	619	15	of	of	IN
cord-023168-cd7adns8	619	16	Africa	Africa	NNP
cord-023168-cd7adns8	619	17	,	,	,
cord-023168-cd7adns8	619	18	throughout	throughout	IN
cord-023168-cd7adns8	619	19	the	the	DT
cord-023168-cd7adns8	619	20	Middle	Middle	NNP
cord-023168-cd7adns8	619	21	East	East	NNP
cord-023168-cd7adns8	619	22	,	,	,
cord-023168-cd7adns8	619	23	the	the	DT
cord-023168-cd7adns8	619	24	Indian	indian	JJ
cord-023168-cd7adns8	619	25	subcontinent	subcontinent	NN
cord-023168-cd7adns8	619	26	and	and	CC
cord-023168-cd7adns8	619	27	South	South	NNP
cord-023168-cd7adns8	619	28	-	-	HYPH
cord-023168-cd7adns8	619	29	east	east	NN
cord-023168-cd7adns8	619	30	Asia	Asia	NNP
cord-023168-cd7adns8	619	31	.	.	.
cord-023168-cd7adns8	620	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	620	2	E	e	NN
cord-023168-cd7adns8	620	3	prevalence	prevalence	NN
cord-023168-cd7adns8	620	4	is	be	VBZ
cord-023168-cd7adns8	620	5	highest	high	JJS
cord-023168-cd7adns8	620	6	in	in	IN
cord-023168-cd7adns8	620	7	Cambodia	Cambodia	NNP
cord-023168-cd7adns8	620	8	,	,	,
cord-023168-cd7adns8	620	9	Laos	Laos	NNP
cord-023168-cd7adns8	620	10	and	and	CC
cord-023168-cd7adns8	620	11	Thailand	Thailand	NNP
cord-023168-cd7adns8	620	12	and	and	CC
cord-023168-cd7adns8	620	13	can	can	MD
cord-023168-cd7adns8	620	14	reach	reach	VB
cord-023168-cd7adns8	620	15	50	50	CD
cord-023168-cd7adns8	620	16	-	-	SYM
cord-023168-cd7adns8	620	17	60	60	CD
cord-023168-cd7adns8	620	18	%	%	NN
cord-023168-cd7adns8	620	19	with	with	IN
cord-023168-cd7adns8	620	20	lower	low	JJR
cord-023168-cd7adns8	620	21	prevalence	prevalence	NN
cord-023168-cd7adns8	620	22	rates	rate	NNS
cord-023168-cd7adns8	620	23	in	in	IN
cord-023168-cd7adns8	620	24	Indonesia	Indonesia	NNP
cord-023168-cd7adns8	620	25	,	,	,
cord-023168-cd7adns8	620	26	Malaysia	Malaysia	NNP
cord-023168-cd7adns8	620	27	,	,	,
cord-023168-cd7adns8	620	28	Singapore	Singapore	NNP
cord-023168-cd7adns8	620	29	and	and	CC
cord-023168-cd7adns8	620	30	Vietnam	Vietnam	NNP
cord-023168-cd7adns8	620	31	.	.	.
cord-023168-cd7adns8	621	1	β	β	LS
cord-023168-cd7adns8	621	2	-	-	HYPH
cord-023168-cd7adns8	621	3	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	621	4	β	β	NN
cord-023168-cd7adns8	621	5	-	-	HYPH
cord-023168-cd7adns8	621	6	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	621	7	is	be	VBZ
cord-023168-cd7adns8	621	8	an	an	DT
cord-023168-cd7adns8	621	9	inherited	inherit	VBN
cord-023168-cd7adns8	621	10	quantitative	quantitative	JJ
cord-023168-cd7adns8	621	11	deficiency	deficiency	NN
cord-023168-cd7adns8	621	12	of	of	IN
cord-023168-cd7adns8	621	13	β	β	NN
cord-023168-cd7adns8	621	14	-	-	HYPH
cord-023168-cd7adns8	621	15	globin	globin	NN
cord-023168-cd7adns8	621	16	chains	chain	NNS
cord-023168-cd7adns8	621	17	which	which	WDT
cord-023168-cd7adns8	621	18	are	be	VBP
cord-023168-cd7adns8	621	19	required	require	VBN
cord-023168-cd7adns8	621	20	to	to	TO
cord-023168-cd7adns8	621	21	make	make	VB
cord-023168-cd7adns8	621	22	normal	normal	JJ
cord-023168-cd7adns8	621	23	adult	adult	NN
cord-023168-cd7adns8	621	24	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	621	25	.	.	.
cord-023168-cd7adns8	622	1	130	130	CD
cord-023168-cd7adns8	622	2	More	More	JJR
cord-023168-cd7adns8	622	3	than	than	IN
cord-023168-cd7adns8	622	4	200	200	CD
cord-023168-cd7adns8	622	5	mutations	mutation	NNS
cord-023168-cd7adns8	622	6	have	have	VBP
cord-023168-cd7adns8	622	7	been	be	VBN
cord-023168-cd7adns8	622	8	associated	associate	VBN
cord-023168-cd7adns8	622	9	with	with	IN
cord-023168-cd7adns8	622	10	the	the	DT
cord-023168-cd7adns8	622	11	development	development	NN
cord-023168-cd7adns8	622	12	of	of	IN
cord-023168-cd7adns8	622	13	β	β	NN
cord-023168-cd7adns8	622	14	-	-	HYPH
cord-023168-cd7adns8	622	15	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	622	16	(	(	-LRB-
cord-023168-cd7adns8	622	17	a	a	DT
cord-023168-cd7adns8	622	18	complete	complete	JJ
cord-023168-cd7adns8	622	19	list	list	NN
cord-023168-cd7adns8	622	20	is	be	VBZ
cord-023168-cd7adns8	622	21	available	available	JJ
cord-023168-cd7adns8	622	22	at	at	IN
cord-023168-cd7adns8	622	23	the	the	DT
cord-023168-cd7adns8	622	24	Globin	Globin	NNP
cord-023168-cd7adns8	622	25	Gene	Gene	NNP
cord-023168-cd7adns8	622	26	Server	Server	NNP
cord-023168-cd7adns8	622	27	website	website	NN
cord-023168-cd7adns8	622	28	,	,	,
cord-023168-cd7adns8	622	29	at	at	IN
cord-023168-cd7adns8	622	30	:	:	:
cord-023168-cd7adns8	622	31	http://globin.cse	http://globin.cse	ADD
cord-023168-cd7adns8	622	32	.	.	.
cord-023168-cd7adns8	623	1	psu.edu	psu.edu	NNP
cord-023168-cd7adns8	623	2	)	)	-RRB-
cord-023168-cd7adns8	624	1	and	and	CC
cord-023168-cd7adns8	624	2	they	-PRON-	PRP
cord-023168-cd7adns8	624	3	affect	affect	VBP
cord-023168-cd7adns8	624	4	protein	protein	NN
cord-023168-cd7adns8	624	5	synthesis	synthesis	NN
cord-023168-cd7adns8	624	6	130	130	CD
cord-023168-cd7adns8	624	7	,	,	,
cord-023168-cd7adns8	624	8	131	131	CD
cord-023168-cd7adns8	624	9	leading	lead	VBG
cord-023168-cd7adns8	624	10	to	to	IN
cord-023168-cd7adns8	624	11	reduced	reduce	VBN
cord-023168-cd7adns8	624	12	(	(	-LRB-
cord-023168-cd7adns8	624	13	designated	designate	VBN
cord-023168-cd7adns8	624	14	β	β	NN
cord-023168-cd7adns8	624	15	+	+	CC
cord-023168-cd7adns8	624	16	)	)	-RRB-
cord-023168-cd7adns8	624	17	or	or	CC
cord-023168-cd7adns8	624	18	absent	absent	JJ
cord-023168-cd7adns8	624	19	(	(	-LRB-
cord-023168-cd7adns8	624	20	designated	designate	VBN
cord-023168-cd7adns8	624	21	β	β	NN
cord-023168-cd7adns8	624	22	0	0	CD
cord-023168-cd7adns8	624	23	)	)	-RRB-
cord-023168-cd7adns8	624	24	production	production	NN
cord-023168-cd7adns8	624	25	of	of	IN
cord-023168-cd7adns8	624	26	the	the	DT
cord-023168-cd7adns8	624	27	β	β	NN
cord-023168-cd7adns8	624	28	-	-	HYPH
cord-023168-cd7adns8	624	29	globin	globin	NN
cord-023168-cd7adns8	624	30	chains	chain	NNS
cord-023168-cd7adns8	624	31	.	.	.
cord-023168-cd7adns8	625	1	The	the	DT
cord-023168-cd7adns8	625	2	clinical	clinical	JJ
cord-023168-cd7adns8	625	3	severity	severity	NN
cord-023168-cd7adns8	625	4	of	of	IN
cord-023168-cd7adns8	625	5	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	625	6	can	can	MD
cord-023168-cd7adns8	625	7	be	be	VB
cord-023168-cd7adns8	625	8	lessened	lessen	VBN
cord-023168-cd7adns8	625	9	by	by	IN
cord-023168-cd7adns8	625	10	co	co	JJ
cord-023168-cd7adns8	625	11	-	-	JJ
cord-023168-cd7adns8	625	12	existing	existing	JJ
cord-023168-cd7adns8	625	13	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	625	14	abnormalities	abnormality	NNS
cord-023168-cd7adns8	625	15	such	such	JJ
cord-023168-cd7adns8	625	16	as	as	IN
cord-023168-cd7adns8	625	17	the	the	DT
cord-023168-cd7adns8	625	18	co	co	NN
cord-023168-cd7adns8	625	19	-	-	NN
cord-023168-cd7adns8	625	20	inheritance	inheritance	NN
cord-023168-cd7adns8	625	21	of	of	IN
cord-023168-cd7adns8	625	22	α	α	NN
cord-023168-cd7adns8	625	23	-	-	HYPH
cord-023168-cd7adns8	625	24	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	625	25	and	and	CC
cord-023168-cd7adns8	625	26	increased	increase	VBN
cord-023168-cd7adns8	625	27	production	production	NN
cord-023168-cd7adns8	625	28	of	of	IN
cord-023168-cd7adns8	625	29	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	625	30	F.	F.	NNP
cord-023168-cd7adns8	625	31	132	132	CD
cord-023168-cd7adns8	625	32	,	,	,
cord-023168-cd7adns8	625	33	133	133	CD
cord-023168-cd7adns8	625	34	α	α	NN
cord-023168-cd7adns8	625	35	-	-	HYPH
cord-023168-cd7adns8	625	36	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	625	37	Normal	Normal	NNP
cord-023168-cd7adns8	625	38	α	α	NN
cord-023168-cd7adns8	625	39	-	-	HYPH
cord-023168-cd7adns8	625	40	globin	globin	NN
cord-023168-cd7adns8	625	41	synthesis	synthesis	NN
cord-023168-cd7adns8	625	42	is	be	VBZ
cord-023168-cd7adns8	625	43	regulated	regulate	VBN
cord-023168-cd7adns8	625	44	by	by	IN
cord-023168-cd7adns8	625	45	duplicate	duplicate	JJ
cord-023168-cd7adns8	625	46	α	α	NN
cord-023168-cd7adns8	625	47	-	-	HYPH
cord-023168-cd7adns8	625	48	globin	globin	NN
cord-023168-cd7adns8	625	49	genes	gene	NNS
cord-023168-cd7adns8	625	50	on	on	IN
cord-023168-cd7adns8	625	51	chromosome	chromosome	NN
cord-023168-cd7adns8	625	52	16	16	CD
cord-023168-cd7adns8	625	53	.	.	.
cord-023168-cd7adns8	626	1	The	the	DT
cord-023168-cd7adns8	626	2	genotype	genotype	NN
cord-023168-cd7adns8	626	3	is	be	VBZ
cord-023168-cd7adns8	626	4	usually	usually	RB
cord-023168-cd7adns8	626	5	represented	represent	VBN
cord-023168-cd7adns8	626	6	as	as	IN
cord-023168-cd7adns8	626	7	αα	αα	NN
cord-023168-cd7adns8	626	8	/	/	SYM
cord-023168-cd7adns8	626	9	αα	αα	NN
cord-023168-cd7adns8	626	10	and	and	CC
cord-023168-cd7adns8	626	11	α	α	NN
cord-023168-cd7adns8	626	12	-	-	HYPH
cord-023168-cd7adns8	626	13	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	626	14	usually	usually	RB
cord-023168-cd7adns8	626	15	results	result	VBZ
cord-023168-cd7adns8	626	16	from	from	IN
cord-023168-cd7adns8	626	17	deletion	deletion	NN
cord-023168-cd7adns8	626	18	of	of	IN
cord-023168-cd7adns8	626	19	one	one	CD
cord-023168-cd7adns8	626	20	or	or	CC
cord-023168-cd7adns8	626	21	both	both	CC
cord-023168-cd7adns8	626	22	α	α	NN
cord-023168-cd7adns8	626	23	-	-	HYPH
cord-023168-cd7adns8	626	24	genes	gene	NNS
cord-023168-cd7adns8	626	25	.	.	.
cord-023168-cd7adns8	627	1	Occasionally	occasionally	RB
cord-023168-cd7adns8	627	2	point	point	NN
cord-023168-cd7adns8	627	3	mutations	mutation	NNS
cord-023168-cd7adns8	627	4	in	in	IN
cord-023168-cd7adns8	627	5	critical	critical	JJ
cord-023168-cd7adns8	627	6	regions	region	NNS
cord-023168-cd7adns8	627	7	of	of	IN
cord-023168-cd7adns8	627	8	the	the	DT
cord-023168-cd7adns8	627	9	α	α	NN
cord-023168-cd7adns8	627	10	-	-	HYPH
cord-023168-cd7adns8	627	11	genes	gene	NNS
cord-023168-cd7adns8	627	12	may	may	MD
cord-023168-cd7adns8	627	13	cause	cause	VB
cord-023168-cd7adns8	627	14	non	non	JJ
cord-023168-cd7adns8	627	15	-	-	JJ
cord-023168-cd7adns8	627	16	deletional	deletional	JJ
cord-023168-cd7adns8	627	17	α	α	NN
cord-023168-cd7adns8	627	18	-	-	HYPH
cord-023168-cd7adns8	627	19	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	627	20	(	(	-LRB-
cord-023168-cd7adns8	627	21	α	α	NN
cord-023168-cd7adns8	627	22	T	T	NNP
cord-023168-cd7adns8	627	23	)	)	-RRB-
cord-023168-cd7adns8	627	24	.	.	.
cord-023168-cd7adns8	628	1	130	130	CD
cord-023168-cd7adns8	628	2	Mutations	mutation	NNS
cord-023168-cd7adns8	628	3	can	can	MD
cord-023168-cd7adns8	628	4	completely	completely	RB
cord-023168-cd7adns8	628	5	abolish	abolish	VB
cord-023168-cd7adns8	628	6	expression	expression	NN
cord-023168-cd7adns8	628	7	of	of	IN
cord-023168-cd7adns8	628	8	the	the	DT
cord-023168-cd7adns8	628	9	αgenes	αgene	NNS
cord-023168-cd7adns8	628	10	(	(	-LRB-
cord-023168-cd7adns8	628	11	i.e.	i.e.	FW
cord-023168-cd7adns8	628	12	α	α	NN
cord-023168-cd7adns8	628	13	0	0	CD
cord-023168-cd7adns8	628	14	-thalassaemia	-thalassaemia	CD
cord-023168-cd7adns8	628	15	)	)	-RRB-
cord-023168-cd7adns8	628	16	or	or	CC
cord-023168-cd7adns8	628	17	partially	partially	RB
cord-023168-cd7adns8	628	18	down	down	RB
cord-023168-cd7adns8	628	19	-	-	HYPH
cord-023168-cd7adns8	628	20	regulate	regulate	VB
cord-023168-cd7adns8	628	21	expression	expression	NN
cord-023168-cd7adns8	628	22	(	(	-LRB-
cord-023168-cd7adns8	628	23	α	α	NN
cord-023168-cd7adns8	628	24	+	+	SYM
cord-023168-cd7adns8	628	25	-thalassaemia	-thalassaemia	CD
cord-023168-cd7adns8	628	26	)	)	-RRB-
cord-023168-cd7adns8	628	27	.	.	.
cord-023168-cd7adns8	629	1	130	130	CD
cord-023168-cd7adns8	629	2	Both	both	DT
cord-023168-cd7adns8	629	3	α	α	NN
cord-023168-cd7adns8	629	4	0	0	CD
cord-023168-cd7adns8	629	5	and	and	CC
cord-023168-cd7adns8	629	6	α	α	NN
cord-023168-cd7adns8	629	7	+	+	SYM
cord-023168-cd7adns8	629	8	thalassaemias	thalassaemias	NN
cord-023168-cd7adns8	629	9	can	can	MD
cord-023168-cd7adns8	629	10	occur	occur	VB
cord-023168-cd7adns8	629	11	in	in	IN
cord-023168-cd7adns8	629	12	the	the	DT
cord-023168-cd7adns8	629	13	heterozygous	heterozygous	JJ
cord-023168-cd7adns8	629	14	or	or	CC
cord-023168-cd7adns8	629	15	homozygous	homozygous	JJ
cord-023168-cd7adns8	629	16	state	state	NN
cord-023168-cd7adns8	629	17	or	or	CC
cord-023168-cd7adns8	629	18	as	as	IN
cord-023168-cd7adns8	629	19	a	a	DT
cord-023168-cd7adns8	629	20	compound	compound	NN
cord-023168-cd7adns8	629	21	α	α	NN
cord-023168-cd7adns8	629	22	0	0	CD
cord-023168-cd7adns8	629	23	/α	/α	NN
cord-023168-cd7adns8	629	24	+	+	CC
cord-023168-cd7adns8	629	25	heterozygote	heterozygote	NN
cord-023168-cd7adns8	629	26	form	form	NN
cord-023168-cd7adns8	629	27	(	(	-LRB-
cord-023168-cd7adns8	629	28	Table	table	NN
cord-023168-cd7adns8	629	29	65	65	CD
cord-023168-cd7adns8	629	30	.6	.6	CD
cord-023168-cd7adns8	629	31	)	)	-RRB-
cord-023168-cd7adns8	629	32	.	.	.
cord-023168-cd7adns8	630	1	Underproduction	underproduction	NN
cord-023168-cd7adns8	630	2	of	of	IN
cord-023168-cd7adns8	630	3	α	α	NN
cord-023168-cd7adns8	630	4	-	-	HYPH
cord-023168-cd7adns8	630	5	globin	globin	NN
cord-023168-cd7adns8	630	6	chains	chain	NNS
cord-023168-cd7adns8	630	7	due	due	JJ
cord-023168-cd7adns8	630	8	to	to	IN
cord-023168-cd7adns8	630	9	three	three	CD
cord-023168-cd7adns8	630	10	or	or	CC
cord-023168-cd7adns8	630	11	four	four	CD
cord-023168-cd7adns8	630	12	gene	gene	NN
cord-023168-cd7adns8	630	13	deletions	deletion	NNS
cord-023168-cd7adns8	630	14	gives	give	VBZ
cord-023168-cd7adns8	630	15	rise	rise	NN
cord-023168-cd7adns8	630	16	to	to	IN
cord-023168-cd7adns8	630	17	excess	excess	JJ
cord-023168-cd7adns8	630	18	γ	γ	NN
cord-023168-cd7adns8	630	19	(	(	-LRB-
cord-023168-cd7adns8	630	20	fetal	fetal	JJ
cord-023168-cd7adns8	630	21	)	)	-RRB-
cord-023168-cd7adns8	630	22	or	or	CC
cord-023168-cd7adns8	630	23	β	β	NN
cord-023168-cd7adns8	630	24	(	(	-LRB-
cord-023168-cd7adns8	630	25	adult	adult	NN
cord-023168-cd7adns8	630	26	)	)	-RRB-
cord-023168-cd7adns8	630	27	globin	globin	NN
cord-023168-cd7adns8	630	28	chains	chain	NNS
cord-023168-cd7adns8	630	29	which	which	WDT
cord-023168-cd7adns8	630	30	form	form	VBP
cord-023168-cd7adns8	630	31	tetramers	tetramer	NNS
cord-023168-cd7adns8	630	32	,	,	,
cord-023168-cd7adns8	630	33	called	call	VBD
cord-023168-cd7adns8	630	34	Hb	Hb	NNP
cord-023168-cd7adns8	630	35	Bart	Bart	NNP
cord-023168-cd7adns8	630	36	's	's	POS
cord-023168-cd7adns8	630	37	(	(	-LRB-
cord-023168-cd7adns8	630	38	fetal	fetal	JJ
cord-023168-cd7adns8	630	39	)	)	-RRB-
cord-023168-cd7adns8	630	40	or	or	CC
cord-023168-cd7adns8	630	41	HbH	HbH	NNS
cord-023168-cd7adns8	630	42	(	(	-LRB-
cord-023168-cd7adns8	630	43	adult	adult	NN
cord-023168-cd7adns8	630	44	)	)	-RRB-
cord-023168-cd7adns8	630	45	.	.	.
cord-023168-cd7adns8	631	1	134	134	CD
cord-023168-cd7adns8	631	2	Rare	rare	JJ
cord-023168-cd7adns8	631	3	forms	form	NNS
cord-023168-cd7adns8	631	4	of	of	IN
cord-023168-cd7adns8	631	5	α	α	NN
cord-023168-cd7adns8	631	6	-	-	HYPH
cord-023168-cd7adns8	631	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	631	8	occur	occur	VBP
cord-023168-cd7adns8	631	9	in	in	IN
cord-023168-cd7adns8	631	10	association	association	NN
cord-023168-cd7adns8	631	11	with	with	IN
cord-023168-cd7adns8	631	12	other	other	JJ
cord-023168-cd7adns8	631	13	conditions	condition	NNS
cord-023168-cd7adns8	631	14	such	such	JJ
cord-023168-cd7adns8	631	15	as	as	IN
cord-023168-cd7adns8	631	16	mental	mental	JJ
cord-023168-cd7adns8	631	17	retardation	retardation	NN
cord-023168-cd7adns8	631	18	and	and	CC
cord-023168-cd7adns8	631	19	myelodysplastic/	myelodysplastic/	JJ
cord-023168-cd7adns8	631	20	leukaemia	leukaemia	NN
cord-023168-cd7adns8	631	21	syndrome	syndrome	NN
cord-023168-cd7adns8	631	22	.	.	.
cord-023168-cd7adns8	632	1	135	135	CD
cord-023168-cd7adns8	632	2	,	,	,
cord-023168-cd7adns8	632	3	136	136	CD
cord-023168-cd7adns8	632	4	PATHOPHYSIOLOGY	PATHOPHYSIOLOGY	NNP
cord-023168-cd7adns8	632	5	β	β	NN
cord-023168-cd7adns8	632	6	-	-	HYPH
cord-023168-cd7adns8	632	7	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	632	8	(	(	-LRB-
cord-023168-cd7adns8	632	9	Figure	figure	NN
cord-023168-cd7adns8	632	10	65	65	CD
cord-023168-cd7adns8	632	11	.8	.8	CD
cord-023168-cd7adns8	632	12	)	)	-RRB-
cord-023168-cd7adns8	633	1	Thalassaemias	Thalassaemias	NNP
cord-023168-cd7adns8	633	2	131	131	CD
cord-023168-cd7adns8	633	3	,	,	,
cord-023168-cd7adns8	633	4	137	137	CD
cord-023168-cd7adns8	633	5	,	,	,
cord-023168-cd7adns8	633	6	138	138	CD
cord-023168-cd7adns8	633	7	cause	cause	VB
cord-023168-cd7adns8	633	8	an	an	DT
cord-023168-cd7adns8	633	9	imbalance	imbalance	NN
cord-023168-cd7adns8	633	10	of	of	IN
cord-023168-cd7adns8	633	11	αand	αand	NNP
cord-023168-cd7adns8	633	12	β	β	NN
cord-023168-cd7adns8	633	13	-	-	HYPH
cord-023168-cd7adns8	633	14	globin	globin	NN
cord-023168-cd7adns8	633	15	chain	chain	NN
cord-023168-cd7adns8	633	16	synthesis	synthesis	NN
cord-023168-cd7adns8	633	17	.	.	.
cord-023168-cd7adns8	634	1	In	in	IN
cord-023168-cd7adns8	634	2	homozygous	homozygous	JJ
cord-023168-cd7adns8	634	3	β	β	NN
cord-023168-cd7adns8	634	4	-	-	HYPH
cord-023168-cd7adns8	634	5	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	634	6	,	,	,
cord-023168-cd7adns8	634	7	excess	excess	JJ
cord-023168-cd7adns8	634	8	α	α	NN
cord-023168-cd7adns8	634	9	-	-	HYPH
cord-023168-cd7adns8	634	10	chains	chain	NNS
cord-023168-cd7adns8	634	11	precipitate	precipitate	VBP
cord-023168-cd7adns8	634	12	in	in	IN
cord-023168-cd7adns8	634	13	the	the	DT
cord-023168-cd7adns8	634	14	red	red	JJ
cord-023168-cd7adns8	634	15	cell	cell	NN
cord-023168-cd7adns8	634	16	precursors	precursor	NNS
cord-023168-cd7adns8	634	17	and	and	CC
cord-023168-cd7adns8	634	18	up	up	IN
cord-023168-cd7adns8	634	19	to	to	TO
cord-023168-cd7adns8	634	20	75	75	CD
cord-023168-cd7adns8	634	21	%	%	NN
cord-023168-cd7adns8	634	22	of	of	IN
cord-023168-cd7adns8	634	23	cells	cell	NNS
cord-023168-cd7adns8	634	24	are	be	VBP
cord-023168-cd7adns8	634	25	destroyed	destroy	VBN
cord-023168-cd7adns8	634	26	in	in	IN
cord-023168-cd7adns8	634	27	the	the	DT
cord-023168-cd7adns8	634	28	bone	bone	NN
cord-023168-cd7adns8	634	29	marrow	marrow	NN
cord-023168-cd7adns8	634	30	resulting	result	VBG
cord-023168-cd7adns8	634	31	in	in	IN
cord-023168-cd7adns8	634	32	ineffective	ineffective	JJ
cord-023168-cd7adns8	634	33	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	634	34	and	and	CC
cord-023168-cd7adns8	634	35	a	a	DT
cord-023168-cd7adns8	634	36	shortened	shorten	VBN
cord-023168-cd7adns8	634	37	red	red	JJ
cord-023168-cd7adns8	634	38	cell	cell	NN
cord-023168-cd7adns8	634	39	survival	survival	NN
cord-023168-cd7adns8	634	40	.	.	.
cord-023168-cd7adns8	635	1	The	the	DT
cord-023168-cd7adns8	635	2	red	red	JJ
cord-023168-cd7adns8	635	3	cells	cell	NNS
cord-023168-cd7adns8	635	4	released	release	VBN
cord-023168-cd7adns8	635	5	from	from	IN
cord-023168-cd7adns8	635	6	the	the	DT
cord-023168-cd7adns8	635	7	bone	bone	NN
cord-023168-cd7adns8	635	8	marrow	marrow	NN
cord-023168-cd7adns8	635	9	contain	contain	VBP
cord-023168-cd7adns8	635	10	abnormal	abnormal	JJ
cord-023168-cd7adns8	635	11	α	α	NN
cord-023168-cd7adns8	635	12	-	-	HYPH
cord-023168-cd7adns8	635	13	chains	chain	NNS
cord-023168-cd7adns8	635	14	and	and	CC
cord-023168-cd7adns8	635	15	these	these	DT
cord-023168-cd7adns8	635	16	inclusions	inclusion	NNS
cord-023168-cd7adns8	635	17	promote	promote	VBP
cord-023168-cd7adns8	635	18	destruction	destruction	NN
cord-023168-cd7adns8	635	19	of	of	IN
cord-023168-cd7adns8	635	20	the	the	DT
cord-023168-cd7adns8	635	21	cells	cell	NNS
cord-023168-cd7adns8	635	22	by	by	IN
cord-023168-cd7adns8	635	23	the	the	DT
cord-023168-cd7adns8	635	24	spleen	spleen	NN
cord-023168-cd7adns8	635	25	leading	lead	VBG
cord-023168-cd7adns8	635	26	to	to	IN
cord-023168-cd7adns8	635	27	clinical	clinical	JJ
cord-023168-cd7adns8	635	28	symptoms	symptom	NNS
cord-023168-cd7adns8	635	29	and	and	CC
cord-023168-cd7adns8	635	30	signs	sign	NNS
cord-023168-cd7adns8	635	31	of	of	IN
cord-023168-cd7adns8	635	32	haemolysis	haemolysis	NN
cord-023168-cd7adns8	635	33	.	.	.
cord-023168-cd7adns8	636	1	In	in	IN
cord-023168-cd7adns8	636	2	heterozygotes	heterozygote	NNS
cord-023168-cd7adns8	636	3	,	,	,
cord-023168-cd7adns8	636	4	the	the	DT
cord-023168-cd7adns8	636	5	α	α	NN
cord-023168-cd7adns8	636	6	-	-	HYPH
cord-023168-cd7adns8	636	7	chain	chain	NN
cord-023168-cd7adns8	636	8	excess	excess	NN
cord-023168-cd7adns8	636	9	and	and	CC
cord-023168-cd7adns8	636	10	the	the	DT
cord-023168-cd7adns8	636	11	degree	degree	NN
cord-023168-cd7adns8	636	12	of	of	IN
cord-023168-cd7adns8	636	13	inadequate	inadequate	JJ
cord-023168-cd7adns8	636	14	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	636	15	is	be	VBZ
cord-023168-cd7adns8	636	16	much	much	RB
cord-023168-cd7adns8	636	17	less	less	JJR
cord-023168-cd7adns8	636	18	than	than	IN
cord-023168-cd7adns8	636	19	in	in	IN
cord-023168-cd7adns8	636	20	homozygous	homozygous	JJ
cord-023168-cd7adns8	636	21	β	β	NN
cord-023168-cd7adns8	636	22	-	-	HYPH
cord-023168-cd7adns8	636	23	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	636	24	.	.	.
cord-023168-cd7adns8	637	1	HbF	HbF	NNP
cord-023168-cd7adns8	637	2	production	production	NN
cord-023168-cd7adns8	637	3	normally	normally	RB
cord-023168-cd7adns8	637	4	tails	tail	VBZ
cord-023168-cd7adns8	637	5	off	off	RP
cord-023168-cd7adns8	637	6	within	within	IN
cord-023168-cd7adns8	637	7	a	a	DT
cord-023168-cd7adns8	637	8	few	few	JJ
cord-023168-cd7adns8	637	9	months	month	NNS
cord-023168-cd7adns8	637	10	of	of	IN
cord-023168-cd7adns8	637	11	birth	birth	NN
cord-023168-cd7adns8	637	12	but	but	CC
cord-023168-cd7adns8	637	13	in	in	IN
cord-023168-cd7adns8	637	14	β	β	NNP
cord-023168-cd7adns8	637	15	-	-	HYPH
cord-023168-cd7adns8	637	16	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	637	17	HbF	HbF	NNP
cord-023168-cd7adns8	637	18	production	production	NN
cord-023168-cd7adns8	637	19	can	can	MD
cord-023168-cd7adns8	637	20	continue	continue	VB
cord-023168-cd7adns8	637	21	into	into	IN
cord-023168-cd7adns8	637	22	adulthood	adulthood	NN
cord-023168-cd7adns8	637	23	.	.	.
cord-023168-cd7adns8	638	1	The	the	DT
cord-023168-cd7adns8	638	2	effect	effect	NN
cord-023168-cd7adns8	638	3	of	of	IN
cord-023168-cd7adns8	638	4	increased	increase	VBN
cord-023168-cd7adns8	638	5	HbF	hbf	JJ
cord-023168-cd7adns8	638	6	production	production	NN
cord-023168-cd7adns8	638	7	is	be	VBZ
cord-023168-cd7adns8	638	8	to	to	TO
cord-023168-cd7adns8	638	9	prevent	prevent	VB
cord-023168-cd7adns8	638	10	precipitation	precipitation	NN
cord-023168-cd7adns8	638	11	of	of	IN
cord-023168-cd7adns8	638	12	the	the	DT
cord-023168-cd7adns8	638	13	excess	excess	JJ
cord-023168-cd7adns8	638	14	globin	globin	NN
cord-023168-cd7adns8	638	15	chains	chain	NNS
cord-023168-cd7adns8	638	16	and	and	CC
cord-023168-cd7adns8	638	17	consequent	consequent	JJ
cord-023168-cd7adns8	638	18	ineffective	ineffective	JJ
cord-023168-cd7adns8	638	19	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	638	20	.	.	.
cord-023168-cd7adns8	639	1	However	however	RB
cord-023168-cd7adns8	639	2	HbF	HbF	NNP
cord-023168-cd7adns8	639	3	has	have	VBZ
cord-023168-cd7adns8	639	4	a	a	DT
cord-023168-cd7adns8	639	5	high	high	JJ
cord-023168-cd7adns8	639	6	oxygen	oxygen	NN
cord-023168-cd7adns8	639	7	affinity	affinity	NN
cord-023168-cd7adns8	639	8	,	,	,
cord-023168-cd7adns8	639	9	which	which	WDT
cord-023168-cd7adns8	639	10	can	can	MD
cord-023168-cd7adns8	639	11	lead	lead	VB
cord-023168-cd7adns8	639	12	to	to	IN
cord-023168-cd7adns8	639	13	increased	increase	VBN
cord-023168-cd7adns8	639	14	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	639	15	production	production	NN
cord-023168-cd7adns8	639	16	and	and	CC
cord-023168-cd7adns8	639	17	thus	thus	RB
cord-023168-cd7adns8	639	18	,	,	,
cord-023168-cd7adns8	639	19	increased	increase	VBN
cord-023168-cd7adns8	639	20	bone	bone	NN
cord-023168-cd7adns8	639	21	marrow	marrow	NN
cord-023168-cd7adns8	639	22	expansion	expansion	NN
cord-023168-cd7adns8	639	23	.	.	.
cord-023168-cd7adns8	640	1	The	the	DT
cord-023168-cd7adns8	640	2	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	640	3	of	of	IN
cord-023168-cd7adns8	640	4	α	α	NN
cord-023168-cd7adns8	640	5	-	-	HYPH
cord-023168-cd7adns8	640	6	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	640	7	,	,	,
cord-023168-cd7adns8	640	8	and	and	CC
cord-023168-cd7adns8	640	9	hence	hence	RB
cord-023168-cd7adns8	640	10	the	the	DT
cord-023168-cd7adns8	640	11	clinical	clinical	JJ
cord-023168-cd7adns8	640	12	manifestations	manifestation	NNS
cord-023168-cd7adns8	640	13	,	,	,
cord-023168-cd7adns8	640	14	is	be	VBZ
cord-023168-cd7adns8	640	15	quite	quite	RB
cord-023168-cd7adns8	640	16	different	different	JJ
cord-023168-cd7adns8	640	17	from	from	IN
cord-023168-cd7adns8	640	18	β	β	NN
cord-023168-cd7adns8	640	19	-	-	HYPH
cord-023168-cd7adns8	640	20	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	640	21	.	.	.
cord-023168-cd7adns8	641	1	The	the	DT
cord-023168-cd7adns8	641	2	excess	excess	JJ
cord-023168-cd7adns8	641	3	non	non	AFX
cord-023168-cd7adns8	641	4	-	-	JJ
cord-023168-cd7adns8	641	5	α	α	JJ
cord-023168-cd7adns8	641	6	-	-	HYPH
cord-023168-cd7adns8	641	7	globin	globin	NN
cord-023168-cd7adns8	641	8	chains	chain	NNS
cord-023168-cd7adns8	641	9	form	form	VBP
cord-023168-cd7adns8	641	10	soluble	soluble	JJ
cord-023168-cd7adns8	641	11	tetramers	tetramer	NNS
cord-023168-cd7adns8	641	12	rather	rather	RB
cord-023168-cd7adns8	641	13	than	than	IN
cord-023168-cd7adns8	641	14	precipitates	precipitate	VBZ
cord-023168-cd7adns8	641	15	so	so	RB
cord-023168-cd7adns8	641	16	there	there	EX
cord-023168-cd7adns8	641	17	is	be	VBZ
cord-023168-cd7adns8	641	18	only	only	RB
cord-023168-cd7adns8	641	19	minimal	minimal	JJ
cord-023168-cd7adns8	641	20	ineffective	ineffective	JJ
cord-023168-cd7adns8	641	21	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	641	22	.	.	.
cord-023168-cd7adns8	642	1	The	the	DT
cord-023168-cd7adns8	642	2	only	only	JJ
cord-023168-cd7adns8	642	3	clinical	clinical	JJ
cord-023168-cd7adns8	642	4	abnormality	abnormality	NN
cord-023168-cd7adns8	642	5	in	in	IN
cord-023168-cd7adns8	642	6	those	those	DT
cord-023168-cd7adns8	642	7	with	with	IN
cord-023168-cd7adns8	642	8	HbH	HbH	NNS
cord-023168-cd7adns8	642	9	may	may	MD
cord-023168-cd7adns8	642	10	be	be	VB
cord-023168-cd7adns8	642	11	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	642	12	secondary	secondary	JJ
cord-023168-cd7adns8	642	13	to	to	IN
cord-023168-cd7adns8	642	14	increased	increase	VBN
cord-023168-cd7adns8	642	15	work	work	NN
cord-023168-cd7adns8	642	16	load	load	NN
cord-023168-cd7adns8	642	17	from	from	IN
cord-023168-cd7adns8	642	18	destruction	destruction	NN
cord-023168-cd7adns8	642	19	of	of	IN
cord-023168-cd7adns8	642	20	red	red	JJ
cord-023168-cd7adns8	642	21	cells	cell	NNS
cord-023168-cd7adns8	642	22	containing	contain	VBG
cord-023168-cd7adns8	642	23	inclusions	inclusion	NNS
cord-023168-cd7adns8	642	24	.	.	.
cord-023168-cd7adns8	643	1	Rarely	rarely	RB
cord-023168-cd7adns8	643	2	anaemia	anaemia	NN
cord-023168-cd7adns8	643	3	may	may	MD
cord-023168-cd7adns8	643	4	be	be	VB
cord-023168-cd7adns8	643	5	severe	severe	JJ
cord-023168-cd7adns8	643	6	enough	enough	RB
cord-023168-cd7adns8	643	7	to	to	TO
cord-023168-cd7adns8	643	8	require	require	VB
cord-023168-cd7adns8	643	9	blood	blood	NN
cord-023168-cd7adns8	643	10	transfusions	transfusion	NNS
cord-023168-cd7adns8	643	11	.	.	.
cord-023168-cd7adns8	644	1	Classification	classification	NN
cord-023168-cd7adns8	644	2	of	of	IN
cord-023168-cd7adns8	644	3	α	α	NN
cord-023168-cd7adns8	644	4	-	-	HYPH
cord-023168-cd7adns8	644	5	Thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	644	6	divide	divide	VB
cord-023168-cd7adns8	644	7	β	β	NN
cord-023168-cd7adns8	644	8	-	-	HYPH
cord-023168-cd7adns8	644	9	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	644	10	into	into	IN
cord-023168-cd7adns8	644	11	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	644	12	major	major	JJ
cord-023168-cd7adns8	644	13	(	(	-LRB-
cord-023168-cd7adns8	644	14	transfusiondependent	transfusiondependent	NNP
cord-023168-cd7adns8	644	15	)	)	-RRB-
cord-023168-cd7adns8	644	16	,	,	,
cord-023168-cd7adns8	644	17	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	644	18	intermedia	intermedia	NNP
cord-023168-cd7adns8	644	19	(	(	-LRB-
cord-023168-cd7adns8	644	20	able	able	JJ
cord-023168-cd7adns8	644	21	to	to	TO
cord-023168-cd7adns8	644	22	maintain	maintain	VB
cord-023168-cd7adns8	644	23	adequate	adequate	JJ
cord-023168-cd7adns8	644	24	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	644	25	without	without	IN
cord-023168-cd7adns8	644	26	transfusions	transfusion	NNS
cord-023168-cd7adns8	644	27	or	or	CC
cord-023168-cd7adns8	644	28	requiring	require	VBG
cord-023168-cd7adns8	644	29	less	less	JJR
cord-023168-cd7adns8	644	30	than	than	IN
cord-023168-cd7adns8	644	31	8	8	CD
cord-023168-cd7adns8	644	32	units	unit	NNS
cord-023168-cd7adns8	644	33	/	/	SYM
cord-023168-cd7adns8	644	34	year	year	NN
cord-023168-cd7adns8	644	35	)	)	-RRB-
cord-023168-cd7adns8	644	36	and	and	CC
cord-023168-cd7adns8	644	37	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	644	38	minor	minor	JJ
cord-023168-cd7adns8	644	39	(	(	-LRB-
cord-023168-cd7adns8	644	40	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	644	41	)	)	-RRB-
cord-023168-cd7adns8	644	42	.	.	.
cord-023168-cd7adns8	645	1	139	139	CD
cord-023168-cd7adns8	645	2	Infants	infant	NNS
cord-023168-cd7adns8	645	3	with	with	IN
cord-023168-cd7adns8	645	4	β	β	NN
cord-023168-cd7adns8	645	5	-	-	HYPH
cord-023168-cd7adns8	645	6	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	645	7	are	be	VBP
cord-023168-cd7adns8	645	8	protected	protect	VBN
cord-023168-cd7adns8	645	9	from	from	IN
cord-023168-cd7adns8	645	10	severe	severe	JJ
cord-023168-cd7adns8	645	11	anaemia	anaemia	NN
cord-023168-cd7adns8	645	12	by	by	IN
cord-023168-cd7adns8	645	13	the	the	DT
cord-023168-cd7adns8	645	14	presence	presence	NN
cord-023168-cd7adns8	645	15	of	of	IN
cord-023168-cd7adns8	645	16	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	645	17	F	F	NNP
cord-023168-cd7adns8	645	18	and	and	CC
cord-023168-cd7adns8	645	19	are	be	VBP
cord-023168-cd7adns8	645	20	usually	usually	RB
cord-023168-cd7adns8	645	21	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	645	22	.	.	.
cord-023168-cd7adns8	646	1	Clinical	clinical	JJ
cord-023168-cd7adns8	646	2	manifestations	manifestation	NNS
cord-023168-cd7adns8	646	3	of	of	IN
cord-023168-cd7adns8	646	4	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	646	5	major	major	JJ
cord-023168-cd7adns8	646	6	depend	depend	NN
cord-023168-cd7adns8	646	7	on	on	IN
cord-023168-cd7adns8	646	8	whether	whether	IN
cord-023168-cd7adns8	646	9	adequate	adequate	JJ
cord-023168-cd7adns8	646	10	blood	blood	NN
cord-023168-cd7adns8	646	11	transfusions	transfusion	NNS
cord-023168-cd7adns8	646	12	are	be	VBP
cord-023168-cd7adns8	646	13	available	available	JJ
cord-023168-cd7adns8	646	14	and	and	CC
cord-023168-cd7adns8	646	15	the	the	DT
cord-023168-cd7adns8	646	16	stringency	stringency	NN
cord-023168-cd7adns8	646	17	with	with	IN
cord-023168-cd7adns8	646	18	which	which	WDT
cord-023168-cd7adns8	646	19	iron	iron	NN
cord-023168-cd7adns8	646	20	chelation	chelation	NN
cord-023168-cd7adns8	646	21	is	be	VBZ
cord-023168-cd7adns8	646	22	undertaken	undertake	VBN
cord-023168-cd7adns8	646	23	.	.	.
cord-023168-cd7adns8	647	1	Untreated	untreated	JJ
cord-023168-cd7adns8	647	2	patients	patient	NNS
cord-023168-cd7adns8	647	3	with	with	IN
cord-023168-cd7adns8	647	4	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	647	5	major	major	JJ
cord-023168-cd7adns8	647	6	will	will	MD
cord-023168-cd7adns8	647	7	die	die	VB
cord-023168-cd7adns8	647	8	in	in	IN
cord-023168-cd7adns8	647	9	late	late	JJ
cord-023168-cd7adns8	647	10	infancy	infancy	NN
cord-023168-cd7adns8	647	11	or	or	CC
cord-023168-cd7adns8	647	12	early	early	JJ
cord-023168-cd7adns8	647	13	childhood	childhood	NN
cord-023168-cd7adns8	647	14	from	from	IN
cord-023168-cd7adns8	647	15	the	the	DT
cord-023168-cd7adns8	647	16	effects	effect	NNS
cord-023168-cd7adns8	647	17	of	of	IN
cord-023168-cd7adns8	647	18	severe	severe	JJ
cord-023168-cd7adns8	647	19	anaemia	anaemia	NN
cord-023168-cd7adns8	647	20	.	.	.
cord-023168-cd7adns8	648	1	Those	those	DT
cord-023168-cd7adns8	648	2	who	who	WP
cord-023168-cd7adns8	648	3	receive	receive	VBP
cord-023168-cd7adns8	648	4	sporadic	sporadic	JJ
cord-023168-cd7adns8	648	5	transfusions	transfusion	NNS
cord-023168-cd7adns8	648	6	may	may	MD
cord-023168-cd7adns8	648	7	survive	survive	VB
cord-023168-cd7adns8	648	8	longer	long	RBR
cord-023168-cd7adns8	648	9	but	but	CC
cord-023168-cd7adns8	648	10	suffer	suffer	VB
cord-023168-cd7adns8	648	11	from	from	IN
cord-023168-cd7adns8	648	12	the	the	DT
cord-023168-cd7adns8	648	13	secondary	secondary	JJ
cord-023168-cd7adns8	648	14	effects	effect	NNS
cord-023168-cd7adns8	648	15	of	of	IN
cord-023168-cd7adns8	648	16	anaemia	anaemia	NN
cord-023168-cd7adns8	648	17	,	,	,
cord-023168-cd7adns8	648	18	bony	bony	JJ
cord-023168-cd7adns8	648	19	deformities	deformity	NNS
cord-023168-cd7adns8	648	20	and	and	CC
cord-023168-cd7adns8	648	21	growth	growth	NN
cord-023168-cd7adns8	648	22	retardation	retardation	NN
cord-023168-cd7adns8	648	23	.	.	.
cord-023168-cd7adns8	649	1	The	the	DT
cord-023168-cd7adns8	649	2	clinical	clinical	JJ
cord-023168-cd7adns8	649	3	features	feature	NNS
cord-023168-cd7adns8	649	4	of	of	IN
cord-023168-cd7adns8	649	5	β	β	NN
cord-023168-cd7adns8	649	6	-	-	HYPH
cord-023168-cd7adns8	649	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	649	8	major	major	NN
cord-023168-cd7adns8	649	9	are	be	VBP
cord-023168-cd7adns8	649	10	divided	divide	VBN
cord-023168-cd7adns8	649	11	into	into	IN
cord-023168-cd7adns8	649	12	those	those	DT
cord-023168-cd7adns8	649	13	resulting	result	VBG
cord-023168-cd7adns8	649	14	from	from	IN
cord-023168-cd7adns8	649	15	anaemia	anaemia	NN
cord-023168-cd7adns8	649	16	,	,	,
cord-023168-cd7adns8	649	17	bony	bony	JJ
cord-023168-cd7adns8	649	18	changes	change	NNS
cord-023168-cd7adns8	649	19	and	and	CC
cord-023168-cd7adns8	649	20	iron	iron	NN
cord-023168-cd7adns8	649	21	overload	overload	NN
cord-023168-cd7adns8	649	22	.	.	.
cord-023168-cd7adns8	650	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	650	2	from	from	IN
cord-023168-cd7adns8	650	3	defective	defective	JJ
cord-023168-cd7adns8	650	4	erythropoeisis	erythropoeisis	NN
cord-023168-cd7adns8	650	5	,	,	,
cord-023168-cd7adns8	650	6	decreased	decrease	VBD
cord-023168-cd7adns8	650	7	red	red	JJ
cord-023168-cd7adns8	650	8	cell	cell	NN
cord-023168-cd7adns8	650	9	survival	survival	NN
cord-023168-cd7adns8	650	10	and	and	CC
cord-023168-cd7adns8	650	11	increased	increase	VBN
cord-023168-cd7adns8	650	12	haemolysis	haemolysis	NN
cord-023168-cd7adns8	650	13	in	in	IN
cord-023168-cd7adns8	650	14	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	650	15	major	major	JJ
cord-023168-cd7adns8	650	16	leads	lead	VBZ
cord-023168-cd7adns8	650	17	to	to	IN
cord-023168-cd7adns8	650	18	cardiac	cardiac	JJ
cord-023168-cd7adns8	650	19	decompensation	decompensation	NN
cord-023168-cd7adns8	650	20	,	,	,
cord-023168-cd7adns8	650	21	failure	failure	NN
cord-023168-cd7adns8	650	22	to	to	TO
cord-023168-cd7adns8	650	23	thrive	thrive	VB
cord-023168-cd7adns8	650	24	and	and	CC
cord-023168-cd7adns8	650	25	growth	growth	NN
cord-023168-cd7adns8	650	26	retardation	retardation	NN
cord-023168-cd7adns8	650	27	in	in	IN
cord-023168-cd7adns8	650	28	children	child	NNS
cord-023168-cd7adns8	650	29	.	.	.
cord-023168-cd7adns8	651	1	Splenomegaly	Splenomegaly	NNP
cord-023168-cd7adns8	651	2	,	,	,
cord-023168-cd7adns8	651	3	from	from	IN
cord-023168-cd7adns8	651	4	the	the	DT
cord-023168-cd7adns8	651	5	increased	increase	VBN
cord-023168-cd7adns8	651	6	work	work	NN
cord-023168-cd7adns8	651	7	load	load	NN
cord-023168-cd7adns8	651	8	of	of	IN
cord-023168-cd7adns8	651	9	culling	cull	VBG
cord-023168-cd7adns8	651	10	red	red	JJ
cord-023168-cd7adns8	651	11	cells	cell	NNS
cord-023168-cd7adns8	651	12	with	with	IN
cord-023168-cd7adns8	651	13	inclusion	inclusion	NN
cord-023168-cd7adns8	651	14	bodies	body	NNS
cord-023168-cd7adns8	651	15	,	,	,
cord-023168-cd7adns8	651	16	can	can	MD
cord-023168-cd7adns8	651	17	cause	cause	VB
cord-023168-cd7adns8	651	18	dilutional	dilutional	JJ
cord-023168-cd7adns8	651	19	anaemia	anaemia	NN
cord-023168-cd7adns8	651	20	and	and	CC
cord-023168-cd7adns8	651	21	a	a	DT
cord-023168-cd7adns8	651	22	further	further	JJ
cord-023168-cd7adns8	651	23	drop	drop	NN
cord-023168-cd7adns8	651	24	in	in	IN
cord-023168-cd7adns8	651	25	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	651	26	.	.	.
cord-023168-cd7adns8	652	1	Compensatory	compensatory	JJ
cord-023168-cd7adns8	652	2	extra	extra	JJ
cord-023168-cd7adns8	652	3	-	-	JJ
cord-023168-cd7adns8	652	4	medullary	medullary	JJ
cord-023168-cd7adns8	652	5	haematopoiesis	haematopoiesis	NN
cord-023168-cd7adns8	652	6	can	can	MD
cord-023168-cd7adns8	652	7	lead	lead	VB
cord-023168-cd7adns8	652	8	to	to	IN
cord-023168-cd7adns8	652	9	hepatomegaly	hepatomegaly	NNP
cord-023168-cd7adns8	652	10	and	and	CC
cord-023168-cd7adns8	652	11	occasionally	occasionally	RB
cord-023168-cd7adns8	652	12	vertebral	vertebral	JJ
cord-023168-cd7adns8	652	13	compression	compression	NN
cord-023168-cd7adns8	652	14	and	and	CC
cord-023168-cd7adns8	652	15	neurological	neurological	JJ
cord-023168-cd7adns8	652	16	defects	defect	NNS
cord-023168-cd7adns8	652	17	.	.	.
cord-023168-cd7adns8	653	1	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	653	2	from	from	IN
cord-023168-cd7adns8	653	3	increased	increase	VBN
cord-023168-cd7adns8	653	4	red	red	JJ
cord-023168-cd7adns8	653	5	cell	cell	NN
cord-023168-cd7adns8	653	6	destruction	destruction	NN
cord-023168-cd7adns8	653	7	is	be	VBZ
cord-023168-cd7adns8	653	8	associated	associate	VBN
cord-023168-cd7adns8	653	9	with	with	IN
cord-023168-cd7adns8	653	10	gall	gall	NN
cord-023168-cd7adns8	653	11	stones	stone	NNS
cord-023168-cd7adns8	653	12	in	in	IN
cord-023168-cd7adns8	653	13	up	up	IN
cord-023168-cd7adns8	653	14	to	to	TO
cord-023168-cd7adns8	653	15	20	20	CD
cord-023168-cd7adns8	653	16	%	%	NN
cord-023168-cd7adns8	653	17	of	of	IN
cord-023168-cd7adns8	653	18	individuals	individual	NNS
cord-023168-cd7adns8	653	19	with	with	IN
cord-023168-cd7adns8	653	20	β	β	NN
cord-023168-cd7adns8	653	21	-	-	HYPH
cord-023168-cd7adns8	653	22	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	653	23	.	.	.
cord-023168-cd7adns8	654	1	140	140	CD
cord-023168-cd7adns8	655	1	Another	another	DT
cord-023168-cd7adns8	655	2	consequence	consequence	NN
cord-023168-cd7adns8	655	3	of	of	IN
cord-023168-cd7adns8	655	4	accelerated	accelerated	JJ
cord-023168-cd7adns8	655	5	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	655	6	is	be	VBZ
cord-023168-cd7adns8	655	7	the	the	DT
cord-023168-cd7adns8	655	8	increased	increase	VBN
cord-023168-cd7adns8	655	9	incidence	incidence	NN
cord-023168-cd7adns8	655	10	of	of	IN
cord-023168-cd7adns8	655	11	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	655	12	(	(	-LRB-
cord-023168-cd7adns8	655	13	4	4	CD
cord-023168-cd7adns8	655	14	%	%	NN
cord-023168-cd7adns8	655	15	in	in	IN
cord-023168-cd7adns8	655	16	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	655	17	major	major	NN
cord-023168-cd7adns8	655	18	and	and	CC
cord-023168-cd7adns8	655	19	10	10	CD
cord-023168-cd7adns8	655	20	%	%	NN
cord-023168-cd7adns8	655	21	with	with	IN
cord-023168-cd7adns8	655	22	intermedia	intermedia	NN
cord-023168-cd7adns8	655	23	)	)	-RRB-
cord-023168-cd7adns8	655	24	from	from	IN
cord-023168-cd7adns8	655	25	the	the	DT
cord-023168-cd7adns8	655	26	exposure	exposure	NN
cord-023168-cd7adns8	655	27	of	of	IN
cord-023168-cd7adns8	655	28	negatively	negatively	RB
cord-023168-cd7adns8	655	29	charged	charge	VBN
cord-023168-cd7adns8	655	30	phospholipids	phospholipid	NNS
cord-023168-cd7adns8	655	31	on	on	IN
cord-023168-cd7adns8	655	32	the	the	DT
cord-023168-cd7adns8	655	33	red	red	JJ
cord-023168-cd7adns8	655	34	cell	cell	NN
cord-023168-cd7adns8	655	35	membrane	membrane	NN
cord-023168-cd7adns8	655	36	and	and	CC
cord-023168-cd7adns8	655	37	the	the	DT
cord-023168-cd7adns8	655	38	generation	generation	NN
cord-023168-cd7adns8	655	39	of	of	IN
cord-023168-cd7adns8	655	40	red	red	JJ
cord-023168-cd7adns8	655	41	cell	cell	NN
cord-023168-cd7adns8	655	42	and	and	CC
cord-023168-cd7adns8	655	43	platelet	platelet	NN
cord-023168-cd7adns8	655	44	microparticles	microparticle	NNS
cord-023168-cd7adns8	655	45	.	.	.
cord-023168-cd7adns8	656	1	141	141	CD
cord-023168-cd7adns8	656	2	Splenectomy	Splenectomy	NNP
cord-023168-cd7adns8	656	3	with	with	IN
cord-023168-cd7adns8	656	4	postoperative	postoperative	JJ
cord-023168-cd7adns8	656	5	thrombocytosis	thrombocytosis	NN
cord-023168-cd7adns8	656	6	is	be	VBZ
cord-023168-cd7adns8	656	7	a	a	DT
cord-023168-cd7adns8	656	8	risk	risk	NN
cord-023168-cd7adns8	656	9	factor	factor	NN
cord-023168-cd7adns8	656	10	for	for	IN
cord-023168-cd7adns8	656	11	thrombosis	thrombosis	NN
cord-023168-cd7adns8	656	12	especially	especially	RB
cord-023168-cd7adns8	656	13	if	if	IN
cord-023168-cd7adns8	656	14	combined	combine	VBN
cord-023168-cd7adns8	656	15	with	with	IN
cord-023168-cd7adns8	656	16	endothelial	endothelial	JJ
cord-023168-cd7adns8	656	17	oxidative	oxidative	JJ
cord-023168-cd7adns8	656	18	stress	stress	NN
cord-023168-cd7adns8	656	19	from	from	IN
cord-023168-cd7adns8	656	20	iron	iron	NN
cord-023168-cd7adns8	656	21	overload	overload	NN
cord-023168-cd7adns8	656	22	,	,	,
cord-023168-cd7adns8	656	23	or	or	CC
cord-023168-cd7adns8	656	24	procoagulant	procoagulant	NN
cord-023168-cd7adns8	656	25	co	co	JJ
cord-023168-cd7adns8	656	26	-	-	JJ
cord-023168-cd7adns8	656	27	morbid	morbid	JJ
cord-023168-cd7adns8	656	28	conditions	condition	NNS
cord-023168-cd7adns8	656	29	such	such	JJ
cord-023168-cd7adns8	656	30	as	as	IN
cord-023168-cd7adns8	656	31	diabetes	diabetes	NN
cord-023168-cd7adns8	656	32	mellitus	mellitus	NN
cord-023168-cd7adns8	656	33	,	,	,
cord-023168-cd7adns8	656	34	hormone	hormone	NN
cord-023168-cd7adns8	656	35	therapy	therapy	NN
cord-023168-cd7adns8	656	36	,	,	,
cord-023168-cd7adns8	656	37	thrombophilic	thrombophilic	NNP
cord-023168-cd7adns8	656	38	mutations	mutation	NNS
cord-023168-cd7adns8	656	39	and	and	CC
cord-023168-cd7adns8	656	40	atrial	atrial	JJ
cord-023168-cd7adns8	656	41	fibrillation	fibrillation	NN
cord-023168-cd7adns8	656	42	.	.	.
cord-023168-cd7adns8	657	1	142	142	CD
cord-023168-cd7adns8	657	2	Folate	folate	NN
cord-023168-cd7adns8	657	3	deficiency	deficiency	NN
cord-023168-cd7adns8	657	4	,	,	,
cord-023168-cd7adns8	657	5	hyperuricaemia	hyperuricaemia	NN
cord-023168-cd7adns8	657	6	and	and	CC
cord-023168-cd7adns8	657	7	occasionally	occasionally	RB
cord-023168-cd7adns8	657	8	gout	gout	NN
cord-023168-cd7adns8	657	9	have	have	VBP
cord-023168-cd7adns8	657	10	been	be	VBN
cord-023168-cd7adns8	657	11	observed	observe	VBN
cord-023168-cd7adns8	657	12	in	in	IN
cord-023168-cd7adns8	657	13	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	657	14	major	major	JJ
cord-023168-cd7adns8	657	15	due	due	IN
cord-023168-cd7adns8	657	16	to	to	IN
cord-023168-cd7adns8	657	17	the	the	DT
cord-023168-cd7adns8	657	18	high	high	JJ
cord-023168-cd7adns8	657	19	turnover	turnover	NN
cord-023168-cd7adns8	657	20	of	of	IN
cord-023168-cd7adns8	657	21	red	red	JJ
cord-023168-cd7adns8	657	22	cells	cell	NNS
cord-023168-cd7adns8	657	23	.	.	.
cord-023168-cd7adns8	658	1	The	the	DT
cord-023168-cd7adns8	658	2	enhanced	enhanced	JJ
cord-023168-cd7adns8	658	3	erythropoietic	erythropoietic	NN
cord-023168-cd7adns8	658	4	drive	drive	NN
cord-023168-cd7adns8	658	5	from	from	IN
cord-023168-cd7adns8	658	6	anaemia	anaemia	NN
cord-023168-cd7adns8	658	7	in	in	IN
cord-023168-cd7adns8	658	8	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	658	9	can	can	MD
cord-023168-cd7adns8	658	10	lead	lead	VB
cord-023168-cd7adns8	658	11	to	to	IN
cord-023168-cd7adns8	658	12	increased	increase	VBN
cord-023168-cd7adns8	658	13	marrow	marrow	NN
cord-023168-cd7adns8	658	14	expansion	expansion	NN
cord-023168-cd7adns8	658	15	with	with	IN
cord-023168-cd7adns8	658	16	In	in	IN
cord-023168-cd7adns8	658	17	homozygous	homozygous	JJ
cord-023168-cd7adns8	658	18	β	β	NN
cord-023168-cd7adns8	658	19	-	-	HYPH
cord-023168-cd7adns8	658	20	thalassemia	thalassemia	NN
cord-023168-cd7adns8	658	21	,	,	,
cord-023168-cd7adns8	658	22	β	β	NN
cord-023168-cd7adns8	658	23	-	-	HYPH
cord-023168-cd7adns8	658	24	globin	globin	NN
cord-023168-cd7adns8	658	25	synthesis	synthesis	NN
cord-023168-cd7adns8	658	26	is	be	VBZ
cord-023168-cd7adns8	658	27	markedly	markedly	RB
cord-023168-cd7adns8	658	28	reduced	reduce	VBN
cord-023168-cd7adns8	658	29	or	or	CC
cord-023168-cd7adns8	658	30	absent	absent	JJ
cord-023168-cd7adns8	658	31	.	.	.
cord-023168-cd7adns8	659	1	The	the	DT
cord-023168-cd7adns8	659	2	excess	excess	JJ
cord-023168-cd7adns8	659	3	α	α	NN
cord-023168-cd7adns8	659	4	-	-	HYPH
cord-023168-cd7adns8	659	5	chains	chain	NNS
cord-023168-cd7adns8	659	6	can	can	MD
cord-023168-cd7adns8	659	7	not	not	RB
cord-023168-cd7adns8	659	8	form	form	VB
cord-023168-cd7adns8	659	9	a	a	DT
cord-023168-cd7adns8	659	10	tetramer	tetramer	NN
cord-023168-cd7adns8	659	11	but	but	CC
cord-023168-cd7adns8	659	12	form	form	VB
cord-023168-cd7adns8	659	13	a	a	DT
cord-023168-cd7adns8	659	14	precipitate	precipitate	NN
cord-023168-cd7adns8	659	15	in	in	IN
cord-023168-cd7adns8	659	16	the	the	DT
cord-023168-cd7adns8	659	17	red	red	JJ
cord-023168-cd7adns8	659	18	cell	cell	NN
cord-023168-cd7adns8	659	19	precursors	precursor	NNS
cord-023168-cd7adns8	659	20	leading	lead	VBG
cord-023168-cd7adns8	659	21	to	to	IN
cord-023168-cd7adns8	659	22	intra	intra	JJ
cord-023168-cd7adns8	659	23	-	-	JJ
cord-023168-cd7adns8	659	24	medullary	medullary	JJ
cord-023168-cd7adns8	659	25	destruction	destruction	NN
cord-023168-cd7adns8	659	26	of	of	IN
cord-023168-cd7adns8	659	27	these	these	DT
cord-023168-cd7adns8	659	28	cells	cell	NNS
cord-023168-cd7adns8	659	29	.	.	.
cord-023168-cd7adns8	660	1	This	this	DT
cord-023168-cd7adns8	660	2	destructive	destructive	JJ
cord-023168-cd7adns8	660	3	process	process	NN
cord-023168-cd7adns8	660	4	of	of	IN
cord-023168-cd7adns8	660	5	the	the	DT
cord-023168-cd7adns8	660	6	red	red	JJ
cord-023168-cd7adns8	660	7	cell	cell	NN
cord-023168-cd7adns8	660	8	membrane	membrane	NN
cord-023168-cd7adns8	660	9	occurs	occur	VBZ
cord-023168-cd7adns8	660	10	from	from	IN
cord-023168-cd7adns8	660	11	the	the	DT
cord-023168-cd7adns8	660	12	formation	formation	NN
cord-023168-cd7adns8	660	13	of	of	IN
cord-023168-cd7adns8	660	14	α	α	NN
cord-023168-cd7adns8	660	15	-	-	HYPH
cord-023168-cd7adns8	660	16	chain	chain	NN
cord-023168-cd7adns8	660	17	hemichromes	hemichrome	NNS
cord-023168-cd7adns8	660	18	(	(	-LRB-
cord-023168-cd7adns8	660	19	shown	show	VBN
cord-023168-cd7adns8	660	20	as	as	IN
cord-023168-cd7adns8	660	21	red	red	JJ
cord-023168-cd7adns8	660	22	cell	cell	NN
cord-023168-cd7adns8	660	23	inclusions	inclusion	NNS
cord-023168-cd7adns8	660	24	)	)	-RRB-
cord-023168-cd7adns8	660	25	and	and	CC
cord-023168-cd7adns8	660	26	degradation	degradation	NN
cord-023168-cd7adns8	660	27	products	product	NNS
cord-023168-cd7adns8	660	28	of	of	IN
cord-023168-cd7adns8	660	29	the	the	DT
cord-023168-cd7adns8	660	30	excess	excess	JJ
cord-023168-cd7adns8	660	31	α	α	NN
cord-023168-cd7adns8	660	32	-	-	HYPH
cord-023168-cd7adns8	660	33	chains	chain	NNS
cord-023168-cd7adns8	660	34	.	.	.
cord-023168-cd7adns8	661	1	The	the	DT
cord-023168-cd7adns8	661	2	red	red	JJ
cord-023168-cd7adns8	661	3	cells	cell	NNS
cord-023168-cd7adns8	661	4	which	which	WDT
cord-023168-cd7adns8	661	5	may	may	MD
cord-023168-cd7adns8	661	6	be	be	VB
cord-023168-cd7adns8	661	7	released	release	VBN
cord-023168-cd7adns8	661	8	from	from	IN
cord-023168-cd7adns8	661	9	the	the	DT
cord-023168-cd7adns8	661	10	bone	bone	NN
cord-023168-cd7adns8	661	11	marrow	marrow	NN
cord-023168-cd7adns8	661	12	are	be	VBP
cord-023168-cd7adns8	661	13	destroyed	destroy	VBN
cord-023168-cd7adns8	661	14	by	by	IN
cord-023168-cd7adns8	661	15	the	the	DT
cord-023168-cd7adns8	661	16	spleen	spleen	NN
cord-023168-cd7adns8	661	17	leading	lead	VBG
cord-023168-cd7adns8	661	18	to	to	IN
cord-023168-cd7adns8	661	19	clinical	clinical	JJ
cord-023168-cd7adns8	661	20	symptoms	symptom	NNS
cord-023168-cd7adns8	661	21	and	and	CC
cord-023168-cd7adns8	661	22	signs	sign	NNS
cord-023168-cd7adns8	661	23	of	of	IN
cord-023168-cd7adns8	661	24	haemolysis	haemolysis	NN
cord-023168-cd7adns8	661	25	.	.	.
cord-023168-cd7adns8	662	1	Since	since	IN
cord-023168-cd7adns8	662	2	only	only	RB
cord-023168-cd7adns8	662	3	the	the	DT
cord-023168-cd7adns8	662	4	β	β	NN
cord-023168-cd7adns8	662	5	-	-	HYPH
cord-023168-cd7adns8	662	6	chain	chain	NN
cord-023168-cd7adns8	662	7	is	be	VBZ
cord-023168-cd7adns8	662	8	affected	affect	VBN
cord-023168-cd7adns8	662	9	in	in	IN
cord-023168-cd7adns8	662	10	these	these	DT
cord-023168-cd7adns8	662	11	individuals	individual	NNS
cord-023168-cd7adns8	662	12	,	,	,
cord-023168-cd7adns8	662	13	the	the	DT
cord-023168-cd7adns8	662	14	synthesis	synthesis	NN
cord-023168-cd7adns8	662	15	of	of	IN
cord-023168-cd7adns8	662	16	HbF	HbF	NNP
cord-023168-cd7adns8	662	17	and	and	CC
cord-023168-cd7adns8	662	18	HbA	HbA	NNP
cord-023168-cd7adns8	662	19	2	2	CD
cord-023168-cd7adns8	662	20	continues	continue	VBZ
cord-023168-cd7adns8	662	21	unabated	unabated	JJ
cord-023168-cd7adns8	662	22	.	.	.
cord-023168-cd7adns8	663	1	These	these	DT
cord-023168-cd7adns8	663	2	haemoglobins	haemoglobin	NNS
cord-023168-cd7adns8	663	3	have	have	VBP
cord-023168-cd7adns8	663	4	very	very	RB
cord-023168-cd7adns8	663	5	high	high	JJ
cord-023168-cd7adns8	663	6	oxygen	oxygen	NN
cord-023168-cd7adns8	663	7	affinity	affinity	NN
cord-023168-cd7adns8	663	8	,	,	,
cord-023168-cd7adns8	663	9	which	which	WDT
cord-023168-cd7adns8	663	10	can	can	MD
cord-023168-cd7adns8	663	11	lead	lead	VB
cord-023168-cd7adns8	663	12	to	to	IN
cord-023168-cd7adns8	663	13	increased	increase	VBN
cord-023168-cd7adns8	663	14	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	663	15	production	production	NN
cord-023168-cd7adns8	663	16	and	and	CC
cord-023168-cd7adns8	663	17	thus	thus	RB
cord-023168-cd7adns8	663	18	,	,	,
cord-023168-cd7adns8	663	19	increased	increase	VBN
cord-023168-cd7adns8	663	20	bone	bone	NN
cord-023168-cd7adns8	663	21	marrow	marrow	NN
cord-023168-cd7adns8	663	22	expansion	expansion	NN
cord-023168-cd7adns8	663	23	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	663	24	,	,	,
cord-023168-cd7adns8	663	25	which	which	WDT
cord-023168-cd7adns8	663	26	may	may	MD
cord-023168-cd7adns8	663	27	be	be	VB
cord-023168-cd7adns8	663	28	massive	massive	JJ
cord-023168-cd7adns8	663	29	,	,	,
cord-023168-cd7adns8	663	30	and	and	CC
cord-023168-cd7adns8	663	31	growth	growth	NN
cord-023168-cd7adns8	663	32	retardation	retardation	NN
cord-023168-cd7adns8	663	33	in	in	IN
cord-023168-cd7adns8	663	34	children	child	NNS
cord-023168-cd7adns8	663	35	.	.	.
cord-023168-cd7adns8	664	1	Bony	bony	JJ
cord-023168-cd7adns8	664	2	changes	change	NNS
cord-023168-cd7adns8	664	3	are	be	VBP
cord-023168-cd7adns8	664	4	unusual	unusual	JJ
cord-023168-cd7adns8	664	5	.	.	.
cord-023168-cd7adns8	665	1	Other	other	JJ
cord-023168-cd7adns8	665	2	complications	complication	NNS
cord-023168-cd7adns8	665	3	include	include	VBP
cord-023168-cd7adns8	665	4	infections	infection	NNS
cord-023168-cd7adns8	665	5	,	,	,
cord-023168-cd7adns8	665	6	leg	leg	NN
cord-023168-cd7adns8	665	7	ulcers	ulcer	NNS
cord-023168-cd7adns8	665	8	,	,	,
cord-023168-cd7adns8	665	9	gall	gall	NN
cord-023168-cd7adns8	665	10	stones	stone	NNS
cord-023168-cd7adns8	665	11	and	and	CC
cord-023168-cd7adns8	665	12	acute	acute	JJ
cord-023168-cd7adns8	665	13	haemolysis	haemolysis	NN
cord-023168-cd7adns8	665	14	in	in	IN
cord-023168-cd7adns8	665	15	response	response	NN
cord-023168-cd7adns8	665	16	to	to	IN
cord-023168-cd7adns8	665	17	drugs	drug	NNS
cord-023168-cd7adns8	665	18	and	and	CC
cord-023168-cd7adns8	665	19	infections	infection	NNS
cord-023168-cd7adns8	665	20	.	.	.
cord-023168-cd7adns8	666	1	The	the	DT
cord-023168-cd7adns8	666	2	severity	severity	NN
cord-023168-cd7adns8	666	3	of	of	IN
cord-023168-cd7adns8	666	4	the	the	DT
cord-023168-cd7adns8	666	5	clinical	clinical	JJ
cord-023168-cd7adns8	666	6	features	feature	NNS
cord-023168-cd7adns8	666	7	is	be	VBZ
cord-023168-cd7adns8	666	8	related	relate	VBN
cord-023168-cd7adns8	666	9	to	to	IN
cord-023168-cd7adns8	666	10	the	the	DT
cord-023168-cd7adns8	666	11	molecular	molecular	JJ
cord-023168-cd7adns8	666	12	basis	basis	NN
cord-023168-cd7adns8	666	13	with	with	IN
cord-023168-cd7adns8	666	14	non	non	JJ
cord-023168-cd7adns8	666	15	-	-	JJ
cord-023168-cd7adns8	666	16	deletional	deletional	JJ
cord-023168-cd7adns8	666	17	types	type	NNS
cord-023168-cd7adns8	666	18	of	of	IN
cord-023168-cd7adns8	666	19	HbH	hbh	NN
cord-023168-cd7adns8	666	20	disease	disease	NN
cord-023168-cd7adns8	666	21	more	more	RBR
cord-023168-cd7adns8	666	22	severely	severely	RB
cord-023168-cd7adns8	666	23	affected	affect	VBN
cord-023168-cd7adns8	666	24	.	.	.
cord-023168-cd7adns8	667	1	Haemoglobin	Haemoglobin	NNP
cord-023168-cd7adns8	667	2	Bart	Bart	NNP
cord-023168-cd7adns8	667	3	's	's	POS
cord-023168-cd7adns8	667	4	(	(	-LRB-
cord-023168-cd7adns8	667	5	−/−	−/−	NNP
cord-023168-cd7adns8	667	6	)	)	-RRB-
cord-023168-cd7adns8	667	7	occurs	occur	VBZ
cord-023168-cd7adns8	667	8	almost	almost	RB
cord-023168-cd7adns8	667	9	exclusively	exclusively	RB
cord-023168-cd7adns8	667	10	in	in	IN
cord-023168-cd7adns8	667	11	Asians	Asians	NNPS
cord-023168-cd7adns8	667	12	,	,	,
cord-023168-cd7adns8	667	13	especially	especially	RB
cord-023168-cd7adns8	667	14	Chinese	chinese	JJ
cord-023168-cd7adns8	667	15	,	,	,
cord-023168-cd7adns8	667	16	Cambodian	cambodian	JJ
cord-023168-cd7adns8	667	17	and	and	CC
cord-023168-cd7adns8	667	18	Thai	thai	JJ
cord-023168-cd7adns8	667	19	populations	population	NNS
cord-023168-cd7adns8	667	20	.	.	.
cord-023168-cd7adns8	668	1	An	an	DT
cord-023168-cd7adns8	668	2	infant	infant	NN
cord-023168-cd7adns8	668	3	with	with	IN
cord-023168-cd7adns8	668	4	Hb	Hb	NNP
cord-023168-cd7adns8	668	5	Bart	Bart	NNP
cord-023168-cd7adns8	668	6	's	's	POS
cord-023168-cd7adns8	668	7	hydrops	hydrops	NNP
cord-023168-cd7adns8	668	8	fetalis	fetalis	NNP
cord-023168-cd7adns8	668	9	syndrome	syndrome	NN
cord-023168-cd7adns8	668	10	has	have	VBZ
cord-023168-cd7adns8	668	11	pallor	pallor	NN
cord-023168-cd7adns8	668	12	and	and	CC
cord-023168-cd7adns8	668	13	gross	gross	JJ
cord-023168-cd7adns8	668	14	oedema	oedema	NN
cord-023168-cd7adns8	668	15	with	with	IN
cord-023168-cd7adns8	668	16	signs	sign	NNS
cord-023168-cd7adns8	668	17	of	of	IN
cord-023168-cd7adns8	668	18	cardiac	cardiac	JJ
cord-023168-cd7adns8	668	19	failure	failure	NN
cord-023168-cd7adns8	668	20	,	,	,
cord-023168-cd7adns8	668	21	marked	mark	VBN
cord-023168-cd7adns8	668	22	hepatosplenomegaly	hepatosplenomegaly	NNS
cord-023168-cd7adns8	668	23	and	and	CC
cord-023168-cd7adns8	668	24	skeletal	skeletal	JJ
cord-023168-cd7adns8	668	25	and	and	CC
cord-023168-cd7adns8	668	26	cardiovascular	cardiovascular	JJ
cord-023168-cd7adns8	668	27	deformities	deformity	NNS
cord-023168-cd7adns8	668	28	.	.	.
cord-023168-cd7adns8	669	1	There	there	EX
cord-023168-cd7adns8	669	2	is	be	VBZ
cord-023168-cd7adns8	669	3	often	often	RB
cord-023168-cd7adns8	669	4	gross	gross	JJ
cord-023168-cd7adns8	669	5	hypertrophy	hypertrophy	NN
cord-023168-cd7adns8	669	6	of	of	IN
cord-023168-cd7adns8	669	7	the	the	DT
cord-023168-cd7adns8	669	8	placenta	placenta	NN
cord-023168-cd7adns8	669	9	.	.	.
cord-023168-cd7adns8	670	1	Many	many	JJ
cord-023168-cd7adns8	670	2	of	of	IN
cord-023168-cd7adns8	670	3	the	the	DT
cord-023168-cd7adns8	670	4	clinical	clinical	JJ
cord-023168-cd7adns8	670	5	manifestations	manifestation	NNS
cord-023168-cd7adns8	670	6	of	of	IN
cord-023168-cd7adns8	670	7	this	this	DT
cord-023168-cd7adns8	670	8	condition	condition	NN
cord-023168-cd7adns8	670	9	can	can	MD
cord-023168-cd7adns8	670	10	be	be	VB
cord-023168-cd7adns8	670	11	explained	explain	VBN
cord-023168-cd7adns8	670	12	by	by	IN
cord-023168-cd7adns8	670	13	the	the	DT
cord-023168-cd7adns8	670	14	characteristic	characteristic	JJ
cord-023168-cd7adns8	670	15	bossing	bossing	NN
cord-023168-cd7adns8	670	16	of	of	IN
cord-023168-cd7adns8	670	17	the	the	DT
cord-023168-cd7adns8	670	18	skull	skull	NN
cord-023168-cd7adns8	670	19	and	and	CC
cord-023168-cd7adns8	670	20	overgrowth	overgrowth	NN
cord-023168-cd7adns8	670	21	of	of	IN
cord-023168-cd7adns8	670	22	maxillary	maxillary	JJ
cord-023168-cd7adns8	670	23	region	region	NN
cord-023168-cd7adns8	670	24	,	,	,
cord-023168-cd7adns8	670	25	radiologically	radiologically	RB
cord-023168-cd7adns8	670	26	noted	note	VBN
cord-023168-cd7adns8	670	27	as	as	IN
cord-023168-cd7adns8	670	28	'	'	``
cord-023168-cd7adns8	670	29	hair	hair	NN
cord-023168-cd7adns8	670	30	on	on	IN
cord-023168-cd7adns8	670	31	end	end	NN
cord-023168-cd7adns8	670	32	'	'	''
cord-023168-cd7adns8	670	33	or	or	CC
cord-023168-cd7adns8	670	34	'	'	``
cord-023168-cd7adns8	670	35	sun	sun	NN
cord-023168-cd7adns8	670	36	-	-	HYPH
cord-023168-cd7adns8	670	37	ray	ray	NN
cord-023168-cd7adns8	670	38	'	'	''
cord-023168-cd7adns8	670	39	appearance	appearance	NN
cord-023168-cd7adns8	670	40	.	.	.
cord-023168-cd7adns8	671	1	Metatarsal	Metatarsal	NNP
cord-023168-cd7adns8	671	2	and	and	CC
cord-023168-cd7adns8	671	3	metacarpal	metacarpal	JJ
cord-023168-cd7adns8	671	4	bones	bone	NNS
cord-023168-cd7adns8	671	5	are	be	VBP
cord-023168-cd7adns8	671	6	the	the	DT
cord-023168-cd7adns8	671	7	first	first	JJ
cord-023168-cd7adns8	671	8	to	to	TO
cord-023168-cd7adns8	671	9	expand	expand	VB
cord-023168-cd7adns8	671	10	so	so	RB
cord-023168-cd7adns8	671	11	measurement	measurement	NN
cord-023168-cd7adns8	671	12	of	of	IN
cord-023168-cd7adns8	671	13	the	the	DT
cord-023168-cd7adns8	671	14	metacarpal	metacarpal	JJ
cord-023168-cd7adns8	671	15	bones	bone	NNS
cord-023168-cd7adns8	671	16	has	have	VBZ
cord-023168-cd7adns8	671	17	been	be	VBN
cord-023168-cd7adns8	671	18	considered	consider	VBN
cord-023168-cd7adns8	671	19	a	a	DT
cord-023168-cd7adns8	671	20	good	good	JJ
cord-023168-cd7adns8	671	21	indicator	indicator	NN
cord-023168-cd7adns8	671	22	for	for	IN
cord-023168-cd7adns8	671	23	initiation	initiation	NN
cord-023168-cd7adns8	671	24	of	of	IN
cord-023168-cd7adns8	671	25	transfusion	transfusion	NN
cord-023168-cd7adns8	671	26	therapy	therapy	NN
cord-023168-cd7adns8	671	27	.	.	.
cord-023168-cd7adns8	672	1	143	143	CD
cord-023168-cd7adns8	672	2	Other	other	JJ
cord-023168-cd7adns8	672	3	skeletal	skeletal	JJ
cord-023168-cd7adns8	672	4	deformities	deformity	NNS
cord-023168-cd7adns8	672	5	include	include	VBP
cord-023168-cd7adns8	672	6	shortening	shorten	VBG
cord-023168-cd7adns8	672	7	of	of	IN
cord-023168-cd7adns8	672	8	long	long	JJ
cord-023168-cd7adns8	672	9	bones	bone	NNS
cord-023168-cd7adns8	672	10	due	due	JJ
cord-023168-cd7adns8	672	11	to	to	IN
cord-023168-cd7adns8	672	12	early	early	JJ
cord-023168-cd7adns8	672	13	epiphyseal	epiphyseal	JJ
cord-023168-cd7adns8	672	14	fusion	fusion	NN
cord-023168-cd7adns8	672	15	and	and	CC
cord-023168-cd7adns8	672	16	overgrowth	overgrowth	NN
cord-023168-cd7adns8	672	17	of	of	IN
cord-023168-cd7adns8	672	18	the	the	DT
cord-023168-cd7adns8	672	19	maxilla	maxilla	NN
cord-023168-cd7adns8	672	20	causing	cause	VBG
cord-023168-cd7adns8	672	21	dental	dental	JJ
cord-023168-cd7adns8	672	22	malocclusion	malocclusion	NN
cord-023168-cd7adns8	672	23	.	.	.
cord-023168-cd7adns8	673	1	The	the	DT
cord-023168-cd7adns8	673	2	marrow	marrow	NN
cord-023168-cd7adns8	673	3	expansion	expansion	NN
cord-023168-cd7adns8	673	4	can	can	MD
cord-023168-cd7adns8	673	5	also	also	RB
cord-023168-cd7adns8	673	6	lead	lead	VB
cord-023168-cd7adns8	673	7	to	to	IN
cord-023168-cd7adns8	673	8	pathological	pathological	JJ
cord-023168-cd7adns8	673	9	fractures	fracture	NNS
cord-023168-cd7adns8	673	10	,	,	,
cord-023168-cd7adns8	673	11	early	early	JJ
cord-023168-cd7adns8	673	12	bone	bone	NN
cord-023168-cd7adns8	673	13	thinning	thinning	NN
cord-023168-cd7adns8	673	14	and	and	CC
cord-023168-cd7adns8	673	15	osteoporosis	osteoporosis	NN
cord-023168-cd7adns8	673	16	144	144	CD
cord-023168-cd7adns8	673	17	,	,	,
cord-023168-cd7adns8	673	18	145	145	CD
cord-023168-cd7adns8	673	19	while	while	IN
cord-023168-cd7adns8	673	20	ineffective	ineffective	JJ
cord-023168-cd7adns8	673	21	drainage	drainage	NN
cord-023168-cd7adns8	673	22	of	of	IN
cord-023168-cd7adns8	673	23	the	the	DT
cord-023168-cd7adns8	673	24	sinuses	sinus	NNS
cord-023168-cd7adns8	673	25	and	and	CC
cord-023168-cd7adns8	673	26	middle	middle	JJ
cord-023168-cd7adns8	673	27	ear	ear	NN
cord-023168-cd7adns8	673	28	from	from	IN
cord-023168-cd7adns8	673	29	skull	skull	NN
cord-023168-cd7adns8	673	30	bone	bone	NN
cord-023168-cd7adns8	673	31	overgrowth	overgrowth	NN
cord-023168-cd7adns8	673	32	can	can	MD
cord-023168-cd7adns8	673	33	cause	cause	VB
cord-023168-cd7adns8	673	34	chronic	chronic	JJ
cord-023168-cd7adns8	673	35	sinus	sinus	NN
cord-023168-cd7adns8	673	36	and	and	CC
cord-023168-cd7adns8	673	37	ear	ear	NN
cord-023168-cd7adns8	673	38	infections	infection	NNS
cord-023168-cd7adns8	673	39	.	.	.
cord-023168-cd7adns8	674	1	Growth	growth	NN
cord-023168-cd7adns8	674	2	retardation	retardation	NN
cord-023168-cd7adns8	674	3	is	be	VBZ
cord-023168-cd7adns8	674	4	primarily	primarily	RB
cord-023168-cd7adns8	674	5	the	the	DT
cord-023168-cd7adns8	674	6	result	result	NN
cord-023168-cd7adns8	674	7	of	of	IN
cord-023168-cd7adns8	674	8	anaemia	anaemia	NN
cord-023168-cd7adns8	674	9	with	with	IN
cord-023168-cd7adns8	674	10	contributions	contribution	NNS
cord-023168-cd7adns8	674	11	from	from	IN
cord-023168-cd7adns8	674	12	iron	iron	NN
cord-023168-cd7adns8	674	13	overload	overload	NN
cord-023168-cd7adns8	674	14	,	,	,
cord-023168-cd7adns8	674	15	hypersplenism	hypersplenism	NN
cord-023168-cd7adns8	674	16	,	,	,
cord-023168-cd7adns8	674	17	deficiencies	deficiency	NNS
cord-023168-cd7adns8	674	18	of	of	IN
cord-023168-cd7adns8	674	19	thyroid	thyroid	NN
cord-023168-cd7adns8	674	20	and	and	CC
cord-023168-cd7adns8	674	21	growth	growth	NN
cord-023168-cd7adns8	674	22	hormone	hormone	NN
cord-023168-cd7adns8	674	23	,	,	,
cord-023168-cd7adns8	674	24	hypogonadism	hypogonadism	NN
cord-023168-cd7adns8	674	25	,	,	,
cord-023168-cd7adns8	674	26	zinc	zinc	NN
cord-023168-cd7adns8	674	27	deficiency	deficiency	NN
cord-023168-cd7adns8	674	28	,	,	,
cord-023168-cd7adns8	674	29	chronic	chronic	JJ
cord-023168-cd7adns8	674	30	liver	liver	NN
cord-023168-cd7adns8	674	31	disease	disease	NN
cord-023168-cd7adns8	674	32	,	,	,
cord-023168-cd7adns8	674	33	malnutrition	malnutrition	NN
cord-023168-cd7adns8	674	34	and	and	CC
cord-023168-cd7adns8	674	35	psychosocial	psychosocial	JJ
cord-023168-cd7adns8	674	36	stress	stress	NN
cord-023168-cd7adns8	674	37	.	.	.
cord-023168-cd7adns8	675	1	146	146	CD
cord-023168-cd7adns8	675	2	Patients	patient	NNS
cord-023168-cd7adns8	675	3	with	with	IN
cord-023168-cd7adns8	675	4	β	β	NN
cord-023168-cd7adns8	675	5	-	-	HYPH
cord-023168-cd7adns8	675	6	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	675	7	have	have	VBP
cord-023168-cd7adns8	675	8	increased	increase	VBN
cord-023168-cd7adns8	675	9	iron	iron	NN
cord-023168-cd7adns8	675	10	absorption	absorption	NN
cord-023168-cd7adns8	675	11	mediated	mediate	VBN
cord-023168-cd7adns8	675	12	by	by	IN
cord-023168-cd7adns8	675	13	reduced	reduce	VBN
cord-023168-cd7adns8	675	14	hepcidin	hepcidin	NNS
cord-023168-cd7adns8	675	15	and	and	CC
cord-023168-cd7adns8	675	16	those	those	DT
cord-023168-cd7adns8	675	17	who	who	WP
cord-023168-cd7adns8	675	18	receive	receive	VBP
cord-023168-cd7adns8	675	19	regular	regular	JJ
cord-023168-cd7adns8	675	20	transfusions	transfusion	NNS
cord-023168-cd7adns8	675	21	may	may	MD
cord-023168-cd7adns8	675	22	also	also	RB
cord-023168-cd7adns8	675	23	develop	develop	VB
cord-023168-cd7adns8	675	24	transfusion	transfusion	NN
cord-023168-cd7adns8	675	25	siderosis	siderosis	NN
cord-023168-cd7adns8	675	26	if	if	IN
cord-023168-cd7adns8	675	27	they	-PRON-	PRP
cord-023168-cd7adns8	675	28	are	be	VBP
cord-023168-cd7adns8	675	29	inadequately	inadequately	RB
cord-023168-cd7adns8	675	30	chelated	chelate	VBN
cord-023168-cd7adns8	675	31	.	.	.
cord-023168-cd7adns8	676	1	The	the	DT
cord-023168-cd7adns8	676	2	iron	iron	NN
cord-023168-cd7adns8	676	3	is	be	VBZ
cord-023168-cd7adns8	676	4	deposited	deposit	VBN
cord-023168-cd7adns8	676	5	in	in	IN
cord-023168-cd7adns8	676	6	the	the	DT
cord-023168-cd7adns8	676	7	parenchymal	parenchymal	NN
cord-023168-cd7adns8	676	8	tissues	tissue	NNS
cord-023168-cd7adns8	676	9	with	with	IN
cord-023168-cd7adns8	676	10	a	a	DT
cord-023168-cd7adns8	676	11	variety	variety	NN
cord-023168-cd7adns8	676	12	of	of	IN
cord-023168-cd7adns8	676	13	clinical	clinical	JJ
cord-023168-cd7adns8	676	14	consequences	consequence	NNS
cord-023168-cd7adns8	676	15	(	(	-LRB-
cord-023168-cd7adns8	676	16	Box	Box	NNP
cord-023168-cd7adns8	676	17	65.14	65.14	CD
cord-023168-cd7adns8	676	18	)	)	-RRB-
cord-023168-cd7adns8	676	19	,	,	,
cord-023168-cd7adns8	676	20	[	[	-LRB-
cord-023168-cd7adns8	676	21	147	147	CD
cord-023168-cd7adns8	676	22	]	]	-RRB-
cord-023168-cd7adns8	676	23	[	[	-LRB-
cord-023168-cd7adns8	676	24	148	148	CD
cord-023168-cd7adns8	676	25	]	]	-RRB-
cord-023168-cd7adns8	676	26	[	[	-LRB-
cord-023168-cd7adns8	676	27	149	149	CD
cord-023168-cd7adns8	676	28	]	]	-RRB-
cord-023168-cd7adns8	676	29	[	[	-LRB-
cord-023168-cd7adns8	676	30	150	150	CD
cord-023168-cd7adns8	676	31	]	]	-RRB-
cord-023168-cd7adns8	676	32	[	[	-LRB-
cord-023168-cd7adns8	676	33	151	151	CD
cord-023168-cd7adns8	676	34	]	]	-RRB-
cord-023168-cd7adns8	676	35	[	[	-LRB-
cord-023168-cd7adns8	676	36	152	152	CD
cord-023168-cd7adns8	676	37	]	]	-RRB-
cord-023168-cd7adns8	676	38	[	[	-LRB-
cord-023168-cd7adns8	676	39	153	153	CD
cord-023168-cd7adns8	676	40	]	]	-RRB-
cord-023168-cd7adns8	676	41	[	[	-LRB-
cord-023168-cd7adns8	676	42	154	154	CD
cord-023168-cd7adns8	676	43	]	]	-RRB-
cord-023168-cd7adns8	676	44	a	a	DT
cord-023168-cd7adns8	676	45	process	process	NN
cord-023168-cd7adns8	676	46	which	which	WDT
cord-023168-cd7adns8	676	47	may	may	MD
cord-023168-cd7adns8	676	48	be	be	VB
cord-023168-cd7adns8	676	49	modulated	modulate	VBN
cord-023168-cd7adns8	676	50	by	by	IN
cord-023168-cd7adns8	676	51	variants	variant	NNS
cord-023168-cd7adns8	676	52	in	in	IN
cord-023168-cd7adns8	676	53	the	the	DT
cord-023168-cd7adns8	676	54	haemochromatosis	haemochromatosis	NNP
cord-023168-cd7adns8	676	55	(	(	-LRB-
cord-023168-cd7adns8	676	56	HFE	HFE	NNP
cord-023168-cd7adns8	676	57	)	)	-RRB-
cord-023168-cd7adns8	676	58	gene	gene	NN
cord-023168-cd7adns8	676	59	.	.	.
cord-023168-cd7adns8	677	1	155	155	CD
cord-023168-cd7adns8	677	2	 	 	_SP
cord-023168-cd7adns8	678	1	Thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	678	2	intermedia	intermedia	NN
cord-023168-cd7adns8	678	3	is	be	VBZ
cord-023168-cd7adns8	678	4	characterized	characterize	VBN
cord-023168-cd7adns8	678	5	by	by	IN
cord-023168-cd7adns8	678	6	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	678	7	concentrations	concentration	NNS
cord-023168-cd7adns8	678	8	of	of	IN
cord-023168-cd7adns8	678	9	70	70	CD
cord-023168-cd7adns8	678	10	-	-	SYM
cord-023168-cd7adns8	678	11	100	100	CD
cord-023168-cd7adns8	678	12	g	g	NN
cord-023168-cd7adns8	678	13	/	/	SYM
cord-023168-cd7adns8	678	14	L	l	NN
cord-023168-cd7adns8	678	15	and	and	CC
cord-023168-cd7adns8	678	16	children	child	NNS
cord-023168-cd7adns8	678	17	usually	usually	RB
cord-023168-cd7adns8	678	18	present	present	VBP
cord-023168-cd7adns8	678	19	at	at	IN
cord-023168-cd7adns8	678	20	around	around	RB
cord-023168-cd7adns8	678	21	2	2	CD
cord-023168-cd7adns8	678	22	-	-	SYM
cord-023168-cd7adns8	678	23	4	4	CD
cord-023168-cd7adns8	678	24	years	year	NNS
cord-023168-cd7adns8	678	25	of	of	IN
cord-023168-cd7adns8	678	26	age	age	NN
cord-023168-cd7adns8	678	27	with	with	IN
cord-023168-cd7adns8	678	28	symptoms	symptom	NNS
cord-023168-cd7adns8	678	29	of	of	IN
cord-023168-cd7adns8	678	30	anaemia	anaemia	NN
cord-023168-cd7adns8	678	31	,	,	,
cord-023168-cd7adns8	678	32	jaundice	jaundice	NN
cord-023168-cd7adns8	678	33	and	and	CC
cord-023168-cd7adns8	678	34	hepatosplenomegaly	hepatosplenomegaly	NNS
cord-023168-cd7adns8	678	35	.	.	.
cord-023168-cd7adns8	679	1	156	156	CD
cord-023168-cd7adns8	680	1	There	there	EX
cord-023168-cd7adns8	680	2	may	may	MD
cord-023168-cd7adns8	680	3	also	also	RB
cord-023168-cd7adns8	680	4	be	be	VB
cord-023168-cd7adns8	680	5	skeletal	skeletal	JJ
cord-023168-cd7adns8	680	6	changes	change	NNS
cord-023168-cd7adns8	680	7	such	such	JJ
cord-023168-cd7adns8	680	8	as	as	IN
cord-023168-cd7adns8	680	9	expansion	expansion	NN
cord-023168-cd7adns8	680	10	of	of	IN
cord-023168-cd7adns8	680	11	the	the	DT
cord-023168-cd7adns8	680	12	facial	facial	JJ
cord-023168-cd7adns8	680	13	bones	bone	NNS
cord-023168-cd7adns8	680	14	and	and	CC
cord-023168-cd7adns8	680	15	obliteration	obliteration	NN
cord-023168-cd7adns8	680	16	of	of	IN
cord-023168-cd7adns8	680	17	the	the	DT
cord-023168-cd7adns8	680	18	maxillary	maxillary	JJ
cord-023168-cd7adns8	680	19	sinuses	sinus	NNS
cord-023168-cd7adns8	680	20	.	.	.
cord-023168-cd7adns8	681	1	157	157	CD
cord-023168-cd7adns8	681	2	Several	several	JJ
cord-023168-cd7adns8	681	3	molecular	molecular	JJ
cord-023168-cd7adns8	681	4	factors	factor	NNS
cord-023168-cd7adns8	681	5	including	include	VBG
cord-023168-cd7adns8	681	6	:	:	:
cord-023168-cd7adns8	681	7	(	(	-LRB-
cord-023168-cd7adns8	681	8	a	a	LS
cord-023168-cd7adns8	681	9	)	)	-RRB-
cord-023168-cd7adns8	681	10	coinheritance	coinheritance	NN
cord-023168-cd7adns8	681	11	of	of	IN
cord-023168-cd7adns8	681	12	α	α	NN
cord-023168-cd7adns8	681	13	-	-	HYPH
cord-023168-cd7adns8	681	14	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	681	15	;	;	,
cord-023168-cd7adns8	681	16	(	(	-LRB-
cord-023168-cd7adns8	681	17	b	b	NN
cord-023168-cd7adns8	681	18	)	)	-RRB-
cord-023168-cd7adns8	681	19	hereditary	hereditary	JJ
cord-023168-cd7adns8	681	20	persistence	persistence	NN
cord-023168-cd7adns8	681	21	of	of	IN
cord-023168-cd7adns8	681	22	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	681	23	F	F	NNP
cord-023168-cd7adns8	681	24	;	;	:
cord-023168-cd7adns8	681	25	(	(	-LRB-
cord-023168-cd7adns8	681	26	c	c	NN
cord-023168-cd7adns8	681	27	)	)	-RRB-
cord-023168-cd7adns8	681	28	δβ	δβ	JJ
cord-023168-cd7adns8	681	29	-	-	HYPH
cord-023168-cd7adns8	681	30	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	681	31	and	and	CC
cord-023168-cd7adns8	681	32	(	(	-LRB-
cord-023168-cd7adns8	681	33	d	d	LS
cord-023168-cd7adns8	681	34	)	)	-RRB-
cord-023168-cd7adns8	681	35	the	the	DT
cord-023168-cd7adns8	681	36	specific	specific	JJ
cord-023168-cd7adns8	681	37	GγXmn1	gγxmn1	NN
cord-023168-cd7adns8	681	38	polymorphism	polymorphism	NN
cord-023168-cd7adns8	681	39	contribute	contribute	VBP
cord-023168-cd7adns8	681	40	to	to	IN
cord-023168-cd7adns8	681	41	the	the	DT
cord-023168-cd7adns8	681	42	'	'	``
cord-023168-cd7adns8	681	43	conversion	conversion	NN
cord-023168-cd7adns8	681	44	'	'	''
cord-023168-cd7adns8	681	45	of	of	IN
cord-023168-cd7adns8	681	46	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	681	47	from	from	IN
cord-023168-cd7adns8	681	48	major	major	JJ
cord-023168-cd7adns8	681	49	to	to	IN
cord-023168-cd7adns8	681	50	intermedia	intermedia	NN
cord-023168-cd7adns8	681	51	type	type	NN
cord-023168-cd7adns8	681	52	.	.	.
cord-023168-cd7adns8	682	1	158	158	CD
cord-023168-cd7adns8	683	1	In	in	IN
cord-023168-cd7adns8	683	2	contrast	contrast	NN
cord-023168-cd7adns8	683	3	to	to	IN
cord-023168-cd7adns8	683	4	patients	patient	NNS
cord-023168-cd7adns8	683	5	with	with	IN
cord-023168-cd7adns8	683	6	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	683	7	major	major	NN
cord-023168-cd7adns8	683	8	,	,	,
cord-023168-cd7adns8	683	9	iron	iron	NN
cord-023168-cd7adns8	683	10	loading	loading	NN
cord-023168-cd7adns8	683	11	in	in	IN
cord-023168-cd7adns8	683	12	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	683	13	intermedia	intermedia	NNP
cord-023168-cd7adns8	683	14	occurs	occur	VBZ
cord-023168-cd7adns8	683	15	mainly	mainly	RB
cord-023168-cd7adns8	683	16	as	as	IN
cord-023168-cd7adns8	683	17	a	a	DT
cord-023168-cd7adns8	683	18	result	result	NN
cord-023168-cd7adns8	683	19	of	of	IN
cord-023168-cd7adns8	683	20	increased	increase	VBN
cord-023168-cd7adns8	683	21	intestinal	intestinal	JJ
cord-023168-cd7adns8	683	22	iron	iron	NN
cord-023168-cd7adns8	683	23	absorption	absorption	NN
cord-023168-cd7adns8	683	24	rather	rather	RB
cord-023168-cd7adns8	683	25	than	than	IN
cord-023168-cd7adns8	683	26	transfusion	transfusion	NN
cord-023168-cd7adns8	683	27	therapy	therapy	NN
cord-023168-cd7adns8	683	28	.	.	.
cord-023168-cd7adns8	684	1	Ineffective	ineffective	JJ
cord-023168-cd7adns8	684	2	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	684	3	with	with	IN
cord-023168-cd7adns8	684	4	resultant	resultant	JJ
cord-023168-cd7adns8	684	5	chronic	chronic	JJ
cord-023168-cd7adns8	684	6	anaemia	anaemia	NN
cord-023168-cd7adns8	684	7	and	and	CC
cord-023168-cd7adns8	684	8	hypoxia	hypoxia	NN
cord-023168-cd7adns8	684	9	can	can	MD
cord-023168-cd7adns8	684	10	suppress	suppress	VB
cord-023168-cd7adns8	684	11	hepcidin	hepcidin	NNS
cord-023168-cd7adns8	684	12	,	,	,
cord-023168-cd7adns8	684	13	the	the	DT
cord-023168-cd7adns8	684	14	regulator	regulator	NN
cord-023168-cd7adns8	684	15	of	of	IN
cord-023168-cd7adns8	684	16	iron	iron	NN
cord-023168-cd7adns8	684	17	metabolism	metabolism	NN
cord-023168-cd7adns8	684	18	,	,	,
cord-023168-cd7adns8	684	19	leading	lead	VBG
cord-023168-cd7adns8	684	20	to	to	IN
cord-023168-cd7adns8	684	21	increased	increase	VBN
cord-023168-cd7adns8	684	22	iron	iron	NN
cord-023168-cd7adns8	684	23	absorption	absorption	NN
cord-023168-cd7adns8	684	24	.	.	.
cord-023168-cd7adns8	685	1	158	158	CD
cord-023168-cd7adns8	686	1	The	the	DT
cord-023168-cd7adns8	686	2	excess	excess	JJ
cord-023168-cd7adns8	686	3	iron	iron	NN
cord-023168-cd7adns8	686	4	tends	tend	VBZ
cord-023168-cd7adns8	686	5	to	to	TO
cord-023168-cd7adns8	686	6	accumulate	accumulate	VB
cord-023168-cd7adns8	686	7	in	in	IN
cord-023168-cd7adns8	686	8	the	the	DT
cord-023168-cd7adns8	686	9	liver	liver	NN
cord-023168-cd7adns8	686	10	rather	rather	RB
cord-023168-cd7adns8	686	11	than	than	IN
cord-023168-cd7adns8	686	12	the	the	DT
cord-023168-cd7adns8	686	13	heart	heart	NN
cord-023168-cd7adns8	686	14	.	.	.
cord-023168-cd7adns8	687	1	159	159	CD
cord-023168-cd7adns8	688	1	Other	other	JJ
cord-023168-cd7adns8	688	2	clinical	clinical	JJ
cord-023168-cd7adns8	688	3	complications	complication	NNS
cord-023168-cd7adns8	688	4	in	in	IN
cord-023168-cd7adns8	688	5	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	688	6	intermedia	intermedia	NN
cord-023168-cd7adns8	688	7	include	include	VBP
cord-023168-cd7adns8	688	8	gallstones	gallstone	NNS
cord-023168-cd7adns8	688	9	,	,	,
cord-023168-cd7adns8	688	10	extramedullary	extramedullary	JJ
cord-023168-cd7adns8	688	11	haemopoiesis	haemopoiesis	NNP
cord-023168-cd7adns8	688	12	leg	leg	NN
cord-023168-cd7adns8	688	13	ulcers	ulcer	NNS
cord-023168-cd7adns8	688	14	,	,	,
cord-023168-cd7adns8	688	15	thromboembolic	thromboembolic	JJ
cord-023168-cd7adns8	688	16	events	event	NNS
cord-023168-cd7adns8	688	17	and	and	CC
cord-023168-cd7adns8	688	18	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	688	19	hypertension	hypertension	NN
cord-023168-cd7adns8	688	20	,	,	,
cord-023168-cd7adns8	688	21	which	which	WDT
cord-023168-cd7adns8	688	22	is	be	VBZ
cord-023168-cd7adns8	688	23	the	the	DT
cord-023168-cd7adns8	688	24	major	major	JJ
cord-023168-cd7adns8	688	25	cause	cause	NN
cord-023168-cd7adns8	688	26	of	of	IN
cord-023168-cd7adns8	688	27	heart	heart	NN
cord-023168-cd7adns8	688	28	failure	failure	NN
cord-023168-cd7adns8	688	29	in	in	IN
cord-023168-cd7adns8	688	30	these	these	DT
cord-023168-cd7adns8	688	31	individuals	individual	NNS
cord-023168-cd7adns8	688	32	.	.	.
cord-023168-cd7adns8	689	1	160	160	CD
cord-023168-cd7adns8	690	1	Although	although	IN
cord-023168-cd7adns8	690	2	individuals	individual	NNS
cord-023168-cd7adns8	690	3	with	with	IN
cord-023168-cd7adns8	690	4	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	690	5	intermedia	intermedia	NNP
cord-023168-cd7adns8	690	6	do	do	VBP
cord-023168-cd7adns8	690	7	not	not	RB
cord-023168-cd7adns8	690	8	usually	usually	RB
cord-023168-cd7adns8	690	9	need	need	VB
cord-023168-cd7adns8	690	10	regular	regular	JJ
cord-023168-cd7adns8	690	11	blood	blood	NN
cord-023168-cd7adns8	690	12	transfusions	transfusion	NNS
cord-023168-cd7adns8	690	13	,	,	,
cord-023168-cd7adns8	690	14	there	there	EX
cord-023168-cd7adns8	690	15	is	be	VBZ
cord-023168-cd7adns8	690	16	some	some	DT
cord-023168-cd7adns8	690	17	evidence	evidence	NN
cord-023168-cd7adns8	690	18	that	that	IN
cord-023168-cd7adns8	690	19	complications	complication	NNS
cord-023168-cd7adns8	690	20	,	,	,
cord-023168-cd7adns8	690	21	particularly	particularly	RB
cord-023168-cd7adns8	690	22	later	later	RB
cord-023168-cd7adns8	690	23	in	in	IN
cord-023168-cd7adns8	690	24	life	life	NN
cord-023168-cd7adns8	690	25	,	,	,
cord-023168-cd7adns8	690	26	may	may	MD
cord-023168-cd7adns8	690	27	be	be	VB
cord-023168-cd7adns8	690	28	less	less	RBR
cord-023168-cd7adns8	690	29	common	common	JJ
cord-023168-cd7adns8	690	30	in	in	IN
cord-023168-cd7adns8	690	31	regularly	regularly	RB
cord-023168-cd7adns8	690	32	transfused	transfuse	VBN
cord-023168-cd7adns8	690	33	patients	patient	NNS
cord-023168-cd7adns8	690	34	.	.	.
cord-023168-cd7adns8	691	1	159	159	CD
cord-023168-cd7adns8	691	2	α	α	NN
cord-023168-cd7adns8	691	3	-	-	HYPH
cord-023168-cd7adns8	691	4	Thalassaemias	Thalassaemias	NNP
cord-023168-cd7adns8	691	5	130	130	CD
cord-023168-cd7adns8	691	6	,	,	,
cord-023168-cd7adns8	691	7	134	134	CD
cord-023168-cd7adns8	691	8	Carriers	carrier	NNS
cord-023168-cd7adns8	691	9	of	of	IN
cord-023168-cd7adns8	691	10	α	α	NN
cord-023168-cd7adns8	691	11	-	-	HYPH
cord-023168-cd7adns8	691	12	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	691	13	(	(	-LRB-
cord-023168-cd7adns8	691	14	traits	trait	NNS
cord-023168-cd7adns8	691	15	,	,	,
cord-023168-cd7adns8	691	16	with	with	IN
cord-023168-cd7adns8	691	17	loss	loss	NN
cord-023168-cd7adns8	691	18	of	of	IN
cord-023168-cd7adns8	691	19	1	1	CD
cord-023168-cd7adns8	691	20	or	or	CC
cord-023168-cd7adns8	691	21	2	2	CD
cord-023168-cd7adns8	691	22	α	α	NN
cord-023168-cd7adns8	691	23	genes	gene	NNS
cord-023168-cd7adns8	691	24	)	)	-RRB-
cord-023168-cd7adns8	691	25	are	be	VBP
cord-023168-cd7adns8	691	26	usually	usually	RB
cord-023168-cd7adns8	691	27	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	691	28	and	and	CC
cord-023168-cd7adns8	691	29	may	may	MD
cord-023168-cd7adns8	691	30	only	only	RB
cord-023168-cd7adns8	691	31	be	be	VB
cord-023168-cd7adns8	691	32	detected	detect	VBN
cord-023168-cd7adns8	691	33	through	through	IN
cord-023168-cd7adns8	691	34	a	a	DT
cord-023168-cd7adns8	691	35	routine	routine	JJ
cord-023168-cd7adns8	691	36	blood	blood	NN
cord-023168-cd7adns8	691	37	count	count	NN
cord-023168-cd7adns8	691	38	which	which	WDT
cord-023168-cd7adns8	691	39	shows	show	VBZ
cord-023168-cd7adns8	691	40	mild	mild	JJ
cord-023168-cd7adns8	691	41	to	to	IN
cord-023168-cd7adns8	691	42	moderate	moderate	JJ
cord-023168-cd7adns8	691	43	microcytic	microcytic	JJ
cord-023168-cd7adns8	691	44	,	,	,
cord-023168-cd7adns8	691	45	hypochromic	hypochromic	JJ
cord-023168-cd7adns8	691	46	anaemia	anaemia	NN
cord-023168-cd7adns8	691	47	.	.	.
cord-023168-cd7adns8	692	1	Antenatal	Antenatal	NNP
cord-023168-cd7adns8	692	2	counselling	counselling	NN
cord-023168-cd7adns8	692	3	may	may	MD
cord-023168-cd7adns8	692	4	be	be	VB
cord-023168-cd7adns8	692	5	indicated	indicate	VBN
cord-023168-cd7adns8	692	6	if	if	IN
cord-023168-cd7adns8	692	7	the	the	DT
cord-023168-cd7adns8	692	8	mother	mother	NN
cord-023168-cd7adns8	692	9	has	have	VBZ
cord-023168-cd7adns8	692	10	αα/−	αα/−	NN
cord-023168-cd7adns8	692	11	as	as	IN
cord-023168-cd7adns8	692	12	there	there	EX
cord-023168-cd7adns8	692	13	is	be	VBZ
cord-023168-cd7adns8	692	14	a	a	DT
cord-023168-cd7adns8	692	15	possibility	possibility	NN
cord-023168-cd7adns8	692	16	that	that	IN
cord-023168-cd7adns8	692	17	the	the	DT
cord-023168-cd7adns8	692	18	fetus	fetus	NN
cord-023168-cd7adns8	692	19	may	may	MD
cord-023168-cd7adns8	692	20	be	be	VB
cord-023168-cd7adns8	692	21	at	at	IN
cord-023168-cd7adns8	692	22	risk	risk	NN
cord-023168-cd7adns8	692	23	of	of	IN
cord-023168-cd7adns8	692	24	having	have	VBG
cord-023168-cd7adns8	692	25	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	692	26	Bart	Bart	NNP
cord-023168-cd7adns8	692	27	's	's	POS
cord-023168-cd7adns8	692	28	.	.	.
cord-023168-cd7adns8	693	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	693	2	H	H	NNP
cord-023168-cd7adns8	693	3	disease	disease	NN
cord-023168-cd7adns8	693	4	occurs	occur	VBZ
cord-023168-cd7adns8	693	5	mainly	mainly	RB
cord-023168-cd7adns8	693	6	in	in	IN
cord-023168-cd7adns8	693	7	Asians	Asians	NNPS
cord-023168-cd7adns8	693	8	and	and	CC
cord-023168-cd7adns8	693	9	occasionally	occasionally	RB
cord-023168-cd7adns8	693	10	in	in	IN
cord-023168-cd7adns8	693	11	the	the	DT
cord-023168-cd7adns8	693	12	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	693	13	population	population	NN
cord-023168-cd7adns8	693	14	.	.	.
cord-023168-cd7adns8	694	1	It	-PRON-	PRP
cord-023168-cd7adns8	694	2	is	be	VBZ
cord-023168-cd7adns8	694	3	the	the	DT
cord-023168-cd7adns8	694	4	result	result	NN
cord-023168-cd7adns8	694	5	of	of	IN
cord-023168-cd7adns8	694	6	deletion	deletion	NN
cord-023168-cd7adns8	694	7	of	of	IN
cord-023168-cd7adns8	694	8	three	three	CD
cord-023168-cd7adns8	694	9	α	α	NN
cord-023168-cd7adns8	694	10	genes	gene	NNS
cord-023168-cd7adns8	694	11	(	(	-LRB-
cord-023168-cd7adns8	694	12	α−/−	α−/−	UH
cord-023168-cd7adns8	694	13	)	)	-RRB-
cord-023168-cd7adns8	694	14	and	and	CC
cord-023168-cd7adns8	694	15	can	can	MD
cord-023168-cd7adns8	694	16	produce	produce	VB
cord-023168-cd7adns8	694	17	anaemia	anaemia	NN
cord-023168-cd7adns8	694	18	varying	vary	VBG
cord-023168-cd7adns8	694	19	from	from	IN
cord-023168-cd7adns8	694	20	30	30	CD
cord-023168-cd7adns8	694	21	-	-	SYM
cord-023168-cd7adns8	694	22	130	130	CD
cord-023168-cd7adns8	695	1	g	g	NNP
cord-023168-cd7adns8	695	2	/	/	SYM
cord-023168-cd7adns8	695	3	L.	L.	NNP
cord-023168-cd7adns8	695	4	There	there	EX
cord-023168-cd7adns8	695	5	is	be	VBZ
cord-023168-cd7adns8	695	6	usually	usually	RB
cord-023168-cd7adns8	695	7	associated	associate	VBN
cord-023168-cd7adns8	695	8	 	 	_SP
cord-023168-cd7adns8	696	1	•	•	NNP
cord-023168-cd7adns8	697	1	Hypogonadism	hypogonadism	NN
cord-023168-cd7adns8	697	2	is	be	VBZ
cord-023168-cd7adns8	697	3	the	the	DT
cord-023168-cd7adns8	697	4	most	most	RBS
cord-023168-cd7adns8	697	5	frequent	frequent	JJ
cord-023168-cd7adns8	697	6	complication	complication	NN
cord-023168-cd7adns8	697	7	in	in	IN
cord-023168-cd7adns8	697	8	patients	patient	NNS
cord-023168-cd7adns8	697	9	with	with	IN
cord-023168-cd7adns8	697	10	prevalence	prevalence	NN
cord-023168-cd7adns8	697	11	over	over	IN
cord-023168-cd7adns8	697	12	50	50	CD
cord-023168-cd7adns8	697	13	%	%	NN
cord-023168-cd7adns8	697	14	in	in	IN
cord-023168-cd7adns8	697	15	both	both	DT
cord-023168-cd7adns8	697	16	males	male	NNS
cord-023168-cd7adns8	697	17	and	and	CC
cord-023168-cd7adns8	697	18	females	female	NNS
cord-023168-cd7adns8	697	19	.	.	.
cord-023168-cd7adns8	698	1	It	-PRON-	PRP
cord-023168-cd7adns8	698	2	is	be	VBZ
cord-023168-cd7adns8	698	3	usually	usually	RB
cord-023168-cd7adns8	698	4	hypogonadotrophic	hypogonadotrophic	JJ
cord-023168-cd7adns8	698	5	suggesting	suggest	VBG
cord-023168-cd7adns8	698	6	iron	iron	NN
cord-023168-cd7adns8	698	7	damage	damage	NN
cord-023168-cd7adns8	698	8	to	to	IN
cord-023168-cd7adns8	698	9	the	the	DT
cord-023168-cd7adns8	698	10	anterior	anterior	JJ
cord-023168-cd7adns8	698	11	pituitary	pituitary	NN
cord-023168-cd7adns8	698	12	or	or	CC
cord-023168-cd7adns8	698	13	hypothalamus	hypothalamus	NN
cord-023168-cd7adns8	698	14	.	.	.
cord-023168-cd7adns8	699	1	The	the	DT
cord-023168-cd7adns8	699	2	features	feature	NNS
cord-023168-cd7adns8	699	3	range	range	VBP
cord-023168-cd7adns8	699	4	from	from	IN
cord-023168-cd7adns8	699	5	total	total	JJ
cord-023168-cd7adns8	699	6	absence	absence	NN
cord-023168-cd7adns8	699	7	of	of	IN
cord-023168-cd7adns8	699	8	sexual	sexual	JJ
cord-023168-cd7adns8	699	9	development	development	NN
cord-023168-cd7adns8	699	10	to	to	IN
cord-023168-cd7adns8	699	11	delayed	delay	VBN
cord-023168-cd7adns8	699	12	puberty	puberty	NN
cord-023168-cd7adns8	699	13	.	.	.
cord-023168-cd7adns8	700	1	In	in	IN
cord-023168-cd7adns8	700	2	females	female	NNS
cord-023168-cd7adns8	700	3	with	with	IN
cord-023168-cd7adns8	700	4	normal	normal	JJ
cord-023168-cd7adns8	700	5	menstrual	menstrual	JJ
cord-023168-cd7adns8	700	6	function	function	NN
cord-023168-cd7adns8	700	7	,	,	,
cord-023168-cd7adns8	700	8	fertility	fertility	NN
cord-023168-cd7adns8	700	9	is	be	VBZ
cord-023168-cd7adns8	700	10	normal	normal	JJ
cord-023168-cd7adns8	700	11	with	with	IN
cord-023168-cd7adns8	700	12	the	the	DT
cord-023168-cd7adns8	700	13	ovarian	ovarian	JJ
cord-023168-cd7adns8	700	14	function	function	NN
cord-023168-cd7adns8	700	15	preserved	preserve	VBN
cord-023168-cd7adns8	700	16	in	in	IN
cord-023168-cd7adns8	700	17	most	most	RBS
cord-023168-cd7adns8	700	18	although	although	IN
cord-023168-cd7adns8	700	19	secondary	secondary	JJ
cord-023168-cd7adns8	700	20	amenorrhoea	amenorrhoea	NNS
cord-023168-cd7adns8	700	21	can	can	MD
cord-023168-cd7adns8	700	22	develop	develop	VB
cord-023168-cd7adns8	700	23	.	.	.
cord-023168-cd7adns8	701	1	Damage	damage	NN
cord-023168-cd7adns8	701	2	of	of	IN
cord-023168-cd7adns8	701	3	the	the	DT
cord-023168-cd7adns8	701	4	ovaries	ovary	NNS
cord-023168-cd7adns8	701	5	is	be	VBZ
cord-023168-cd7adns8	701	6	rare	rare	JJ
cord-023168-cd7adns8	701	7	and	and	CC
cord-023168-cd7adns8	701	8	is	be	VBZ
cord-023168-cd7adns8	701	9	more	more	RBR
cord-023168-cd7adns8	701	10	likely	likely	JJ
cord-023168-cd7adns8	701	11	to	to	TO
cord-023168-cd7adns8	701	12	appear	appear	VB
cord-023168-cd7adns8	701	13	in	in	IN
cord-023168-cd7adns8	701	14	older	old	JJR
cord-023168-cd7adns8	701	15	women	woman	NNS
cord-023168-cd7adns8	701	16	(	(	-LRB-
cord-023168-cd7adns8	701	17	around	around	RB
cord-023168-cd7adns8	701	18	30	30	CD
cord-023168-cd7adns8	701	19	)	)	-RRB-
cord-023168-cd7adns8	701	20	because	because	IN
cord-023168-cd7adns8	701	21	of	of	IN
cord-023168-cd7adns8	701	22	high	high	JJ
cord-023168-cd7adns8	701	23	vascular	vascular	JJ
cord-023168-cd7adns8	701	24	activity	activity	NN
cord-023168-cd7adns8	701	25	on	on	IN
cord-023168-cd7adns8	701	26	the	the	DT
cord-023168-cd7adns8	701	27	ovaries	ovary	NNS
cord-023168-cd7adns8	701	28	at	at	IN
cord-023168-cd7adns8	701	29	this	this	DT
cord-023168-cd7adns8	701	30	age	age	NN
cord-023168-cd7adns8	701	31	.	.	.
cord-023168-cd7adns8	702	1	Secondary	secondary	JJ
cord-023168-cd7adns8	702	2	hypogonadism	hypogonadism	NN
cord-023168-cd7adns8	702	3	is	be	VBZ
cord-023168-cd7adns8	702	4	common	common	JJ
cord-023168-cd7adns8	702	5	(	(	-LRB-
cord-023168-cd7adns8	702	6	50	50	CD
cord-023168-cd7adns8	702	7	%	%	NN
cord-023168-cd7adns8	702	8	)	)	-RRB-
cord-023168-cd7adns8	702	9	in	in	IN
cord-023168-cd7adns8	702	10	older	old	JJR
cord-023168-cd7adns8	702	11	men	man	NNS
cord-023168-cd7adns8	702	12	.	.	.
cord-023168-cd7adns8	703	1	Serum	serum	NN
cord-023168-cd7adns8	703	2	ferritin	ferritin	NN
cord-023168-cd7adns8	703	3	>	>	XX
cord-023168-cd7adns8	704	1	2000	2000	CD
cord-023168-cd7adns8	704	2	ng	ng	NN
cord-023168-cd7adns8	704	3	/	/	SYM
cord-023168-cd7adns8	704	4	mL	mL	NNP
cord-023168-cd7adns8	704	5	is	be	VBZ
cord-023168-cd7adns8	704	6	a	a	DT
cord-023168-cd7adns8	704	7	risk	risk	NN
cord-023168-cd7adns8	704	8	factor	factor	NN
cord-023168-cd7adns8	704	9	.	.	.
cord-023168-cd7adns8	705	1	•	•	NNP
cord-023168-cd7adns8	706	1	Hypothyroidism	hypothyroidism	NN
cord-023168-cd7adns8	706	2	is	be	VBZ
cord-023168-cd7adns8	706	3	the	the	DT
cord-023168-cd7adns8	706	4	second	second	JJ
cord-023168-cd7adns8	706	5	most	most	RBS
cord-023168-cd7adns8	706	6	common	common	JJ
cord-023168-cd7adns8	706	7	endocrine	endocrine	JJ
cord-023168-cd7adns8	706	8	disorder	disorder	NN
cord-023168-cd7adns8	706	9	(	(	-LRB-
cord-023168-cd7adns8	706	10	about	about	RB
cord-023168-cd7adns8	706	11	20	20	CD
cord-023168-cd7adns8	706	12	%	%	NN
cord-023168-cd7adns8	706	13	)	)	-RRB-
cord-023168-cd7adns8	706	14	although	although	IN
cord-023168-cd7adns8	706	15	many	many	JJ
cord-023168-cd7adns8	706	16	of	of	IN
cord-023168-cd7adns8	706	17	them	-PRON-	PRP
cord-023168-cd7adns8	706	18	may	may	MD
cord-023168-cd7adns8	706	19	have	have	VB
cord-023168-cd7adns8	706	20	the	the	DT
cord-023168-cd7adns8	706	21	subclinical	subclinical	JJ
cord-023168-cd7adns8	706	22	variety	variety	NN
cord-023168-cd7adns8	706	23	.	.	.
cord-023168-cd7adns8	707	1	Most	most	RBS
cord-023168-cd7adns8	707	2	commonly	commonly	RB
cord-023168-cd7adns8	707	3	hypothyroidism	hypothyroidism	NN
cord-023168-cd7adns8	707	4	is	be	VBZ
cord-023168-cd7adns8	707	5	of	of	IN
cord-023168-cd7adns8	707	6	the	the	DT
cord-023168-cd7adns8	707	7	primary	primary	JJ
cord-023168-cd7adns8	707	8	type	type	NN
cord-023168-cd7adns8	707	9	with	with	IN
cord-023168-cd7adns8	707	10	secondary	secondary	JJ
cord-023168-cd7adns8	707	11	,	,	,
cord-023168-cd7adns8	707	12	central	central	JJ
cord-023168-cd7adns8	707	13	hypothyroidism	hypothyroidism	NN
cord-023168-cd7adns8	707	14	increasingly	increasingly	RB
cord-023168-cd7adns8	707	15	being	be	VBG
cord-023168-cd7adns8	707	16	diagnosed	diagnose	VBN
cord-023168-cd7adns8	707	17	in	in	IN
cord-023168-cd7adns8	707	18	recent	recent	JJ
cord-023168-cd7adns8	707	19	years	year	NNS
cord-023168-cd7adns8	707	20	.	.	.
cord-023168-cd7adns8	708	1	•	•	NNP
cord-023168-cd7adns8	709	1	The	the	DT
cord-023168-cd7adns8	709	2	prevalence	prevalence	NN
cord-023168-cd7adns8	709	3	of	of	IN
cord-023168-cd7adns8	709	4	diabetes	diabetes	NN
cord-023168-cd7adns8	709	5	mellitus	mellitus	NN
cord-023168-cd7adns8	709	6	is	be	VBZ
cord-023168-cd7adns8	709	7	around	around	RB
cord-023168-cd7adns8	709	8	5	5	CD
cord-023168-cd7adns8	709	9	%	%	NN
cord-023168-cd7adns8	709	10	with	with	IN
cord-023168-cd7adns8	709	11	the	the	DT
cord-023168-cd7adns8	709	12	mean	mean	JJ
cord-023168-cd7adns8	709	13	age	age	NN
cord-023168-cd7adns8	709	14	of	of	IN
cord-023168-cd7adns8	709	15	diagnosis	diagnosis	NN
cord-023168-cd7adns8	709	16	being	be	VBG
cord-023168-cd7adns8	709	17	18	18	CD
cord-023168-cd7adns8	709	18	years	year	NNS
cord-023168-cd7adns8	709	19	.	.	.
cord-023168-cd7adns8	710	1	Impaired	impaired	JJ
cord-023168-cd7adns8	710	2	glucose	glucose	NN
cord-023168-cd7adns8	710	3	tolerance	tolerance	NN
cord-023168-cd7adns8	710	4	occurs	occur	VBZ
cord-023168-cd7adns8	710	5	first	first	RB
cord-023168-cd7adns8	710	6	with	with	IN
cord-023168-cd7adns8	710	7	microvascular	microvascular	JJ
cord-023168-cd7adns8	710	8	damage	damage	NN
cord-023168-cd7adns8	710	9	like	like	IN
cord-023168-cd7adns8	710	10	retinal	retinal	JJ
cord-023168-cd7adns8	710	11	changes	change	NNS
cord-023168-cd7adns8	710	12	being	be	VBG
cord-023168-cd7adns8	710	13	less	less	RBR
cord-023168-cd7adns8	710	14	common	common	JJ
cord-023168-cd7adns8	710	15	than	than	IN
cord-023168-cd7adns8	710	16	the	the	DT
cord-023168-cd7adns8	710	17	conventional	conventional	JJ
cord-023168-cd7adns8	710	18	form	form	NN
cord-023168-cd7adns8	710	19	.	.	.
cord-023168-cd7adns8	711	1	erythroid	erythroid	JJ
cord-023168-cd7adns8	711	2	precursor	precursor	NN
cord-023168-cd7adns8	711	3	destruction	destruction	NN
cord-023168-cd7adns8	711	4	.	.	.
cord-023168-cd7adns8	712	1	Osmotic	osmotic	JJ
cord-023168-cd7adns8	712	2	fragility	fragility	NN
cord-023168-cd7adns8	712	3	is	be	VBZ
cord-023168-cd7adns8	712	4	reduced	reduce	VBN
cord-023168-cd7adns8	712	5	,	,	,
cord-023168-cd7adns8	712	6	sometimes	sometimes	RB
cord-023168-cd7adns8	712	7	strikingly	strikingly	RB
cord-023168-cd7adns8	712	8	so	so	RB
cord-023168-cd7adns8	712	9	since	since	IN
cord-023168-cd7adns8	712	10	in	in	IN
cord-023168-cd7adns8	712	11	some	some	DT
cord-023168-cd7adns8	712	12	cases	case	NNS
cord-023168-cd7adns8	712	13	the	the	DT
cord-023168-cd7adns8	712	14	red	red	JJ
cord-023168-cd7adns8	712	15	blood	blood	NN
cord-023168-cd7adns8	712	16	cells	cell	NNS
cord-023168-cd7adns8	712	17	do	do	VBP
cord-023168-cd7adns8	712	18	not	not	RB
cord-023168-cd7adns8	712	19	haemolyse	haemolyse	NNP
cord-023168-cd7adns8	712	20	even	even	RB
cord-023168-cd7adns8	712	21	in	in	IN
cord-023168-cd7adns8	712	22	distilled	distil	VBN
cord-023168-cd7adns8	712	23	water	water	NN
cord-023168-cd7adns8	712	24	.	.	.
cord-023168-cd7adns8	713	1	161	161	CD
cord-023168-cd7adns8	714	1	For	for	IN
cord-023168-cd7adns8	714	2	this	this	DT
cord-023168-cd7adns8	714	3	reason	reason	NN
cord-023168-cd7adns8	714	4	,	,	,
cord-023168-cd7adns8	714	5	if	if	IN
cord-023168-cd7adns8	714	6	sophisticated	sophisticated	JJ
cord-023168-cd7adns8	714	7	tests	test	NNS
cord-023168-cd7adns8	714	8	are	be	VBP
cord-023168-cd7adns8	714	9	not	not	RB
cord-023168-cd7adns8	714	10	available	available	JJ
cord-023168-cd7adns8	714	11	,	,	,
cord-023168-cd7adns8	714	12	osmotic	osmotic	JJ
cord-023168-cd7adns8	714	13	fragility	fragility	NN
cord-023168-cd7adns8	714	14	can	can	MD
cord-023168-cd7adns8	714	15	be	be	VB
cord-023168-cd7adns8	714	16	used	use	VBN
cord-023168-cd7adns8	714	17	as	as	IN
cord-023168-cd7adns8	714	18	a	a	DT
cord-023168-cd7adns8	714	19	screening	screening	NN
cord-023168-cd7adns8	714	20	test	test	NN
cord-023168-cd7adns8	714	21	for	for	IN
cord-023168-cd7adns8	714	22	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	714	23	trait	trait	NN
cord-023168-cd7adns8	714	24	.	.	.
cord-023168-cd7adns8	715	1	Serum	serum	NN
cord-023168-cd7adns8	715	2	zinc	zinc	NN
cord-023168-cd7adns8	715	3	levels	level	NNS
cord-023168-cd7adns8	715	4	may	may	MD
cord-023168-cd7adns8	715	5	be	be	VB
cord-023168-cd7adns8	715	6	low	low	JJ
cord-023168-cd7adns8	715	7	and	and	CC
cord-023168-cd7adns8	715	8	this	this	DT
cord-023168-cd7adns8	715	9	may	may	MD
cord-023168-cd7adns8	715	10	be	be	VB
cord-023168-cd7adns8	715	11	related	relate	VBN
cord-023168-cd7adns8	715	12	to	to	IN
cord-023168-cd7adns8	715	13	abnormal	abnormal	JJ
cord-023168-cd7adns8	715	14	growth	growth	NN
cord-023168-cd7adns8	715	15	.	.	.
cord-023168-cd7adns8	716	1	162	162	CD
cord-023168-cd7adns8	716	2	Vitamin	vitamin	NN
cord-023168-cd7adns8	716	3	C	c	NN
cord-023168-cd7adns8	716	4	levels	level	NNS
cord-023168-cd7adns8	716	5	may	may	MD
cord-023168-cd7adns8	716	6	also	also	RB
cord-023168-cd7adns8	716	7	be	be	VB
cord-023168-cd7adns8	716	8	low	low	JJ
cord-023168-cd7adns8	716	9	due	due	IN
cord-023168-cd7adns8	716	10	to	to	IN
cord-023168-cd7adns8	716	11	its	-PRON-	PRP$
cord-023168-cd7adns8	716	12	increased	increased	JJ
cord-023168-cd7adns8	716	13	conversion	conversion	NN
cord-023168-cd7adns8	716	14	to	to	IN
cord-023168-cd7adns8	716	15	oxalic	oxalic	JJ
cord-023168-cd7adns8	716	16	acid	acid	NN
cord-023168-cd7adns8	716	17	in	in	IN
cord-023168-cd7adns8	716	18	the	the	DT
cord-023168-cd7adns8	716	19	presence	presence	NN
cord-023168-cd7adns8	716	20	of	of	IN
cord-023168-cd7adns8	716	21	iron	iron	NN
cord-023168-cd7adns8	716	22	overload	overload	NN
cord-023168-cd7adns8	716	23	.	.	.
cord-023168-cd7adns8	717	1	163	163	CD
cord-023168-cd7adns8	717	2	Care	Care	NNP
cord-023168-cd7adns8	717	3	may	may	MD
cord-023168-cd7adns8	717	4	be	be	VB
cord-023168-cd7adns8	717	5	needed	need	VBN
cord-023168-cd7adns8	717	6	if	if	IN
cord-023168-cd7adns8	717	7	folic	folic	JJ
cord-023168-cd7adns8	717	8	acid	acid	NN
cord-023168-cd7adns8	717	9	is	be	VBZ
cord-023168-cd7adns8	717	10	commenced	commence	VBN
cord-023168-cd7adns8	717	11	on	on	IN
cord-023168-cd7adns8	717	12	a	a	DT
cord-023168-cd7adns8	717	13	background	background	NN
cord-023168-cd7adns8	717	14	of	of	IN
cord-023168-cd7adns8	717	15	bone	bone	NN
cord-023168-cd7adns8	717	16	marrow	marrow	NN
cord-023168-cd7adns8	717	17	failure	failure	NN
cord-023168-cd7adns8	717	18	due	due	JJ
cord-023168-cd7adns8	717	19	to	to	IN
cord-023168-cd7adns8	717	20	folate	folate	JJ
cord-023168-cd7adns8	717	21	deficiency	deficiency	NN
cord-023168-cd7adns8	717	22	as	as	IN
cord-023168-cd7adns8	717	23	it	-PRON-	PRP
cord-023168-cd7adns8	717	24	may	may	MD
cord-023168-cd7adns8	717	25	precipitate	precipitate	VB
cord-023168-cd7adns8	717	26	painful	painful	JJ
cord-023168-cd7adns8	717	27	erythropoietic	erythropoietic	JJ
cord-023168-cd7adns8	717	28	crises	crisis	NNS
cord-023168-cd7adns8	717	29	.	.	.
cord-023168-cd7adns8	718	1	164	164	CD
cord-023168-cd7adns8	718	2	MANAGEMENT	MANAGEMENT	NNP
cord-023168-cd7adns8	718	3	A	a	DT
cord-023168-cd7adns8	718	4	comprehensive	comprehensive	JJ
cord-023168-cd7adns8	718	5	management	management	NN
cord-023168-cd7adns8	718	6	plan	plan	NN
cord-023168-cd7adns8	718	7	for	for	IN
cord-023168-cd7adns8	718	8	patients	patient	NNS
cord-023168-cd7adns8	718	9	with	with	IN
cord-023168-cd7adns8	718	10	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	718	11	may	may	MD
cord-023168-cd7adns8	718	12	involve	involve	VB
cord-023168-cd7adns8	718	13	transfusion	transfusion	NN
cord-023168-cd7adns8	718	14	therapy	therapy	NN
cord-023168-cd7adns8	718	15	,	,	,
cord-023168-cd7adns8	718	16	iron	iron	NN
cord-023168-cd7adns8	718	17	chelation	chelation	NN
cord-023168-cd7adns8	718	18	,	,	,
cord-023168-cd7adns8	718	19	splenectomy	splenectomy	NN
cord-023168-cd7adns8	718	20	,	,	,
cord-023168-cd7adns8	718	21	prevention	prevention	NN
cord-023168-cd7adns8	718	22	or	or	CC
cord-023168-cd7adns8	718	23	early	early	JJ
cord-023168-cd7adns8	718	24	treatment	treatment	NN
cord-023168-cd7adns8	718	25	of	of	IN
cord-023168-cd7adns8	718	26	complications	complication	NNS
cord-023168-cd7adns8	718	27	and	and	CC
cord-023168-cd7adns8	718	28	stem	stem	NN
cord-023168-cd7adns8	718	29	cell	cell	NN
cord-023168-cd7adns8	718	30	transplant	transplant	NN
cord-023168-cd7adns8	718	31	.	.	.
cord-023168-cd7adns8	719	1	The	the	DT
cord-023168-cd7adns8	719	2	mainstay	mainstay	NN
cord-023168-cd7adns8	719	3	of	of	IN
cord-023168-cd7adns8	719	4	treatment	treatment	NN
cord-023168-cd7adns8	719	5	for	for	IN
cord-023168-cd7adns8	719	6	the	the	DT
cord-023168-cd7adns8	719	7	severe	severe	JJ
cord-023168-cd7adns8	719	8	forms	form	NNS
cord-023168-cd7adns8	719	9	of	of	IN
cord-023168-cd7adns8	719	10	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	719	11	is	be	VBZ
cord-023168-cd7adns8	719	12	blood	blood	NN
cord-023168-cd7adns8	719	13	transfusion	transfusion	NN
cord-023168-cd7adns8	719	14	with	with	IN
cord-023168-cd7adns8	719	15	the	the	DT
cord-023168-cd7adns8	719	16	aim	aim	NN
cord-023168-cd7adns8	719	17	of	of	IN
cord-023168-cd7adns8	719	18	reducing	reduce	VBG
cord-023168-cd7adns8	719	19	anaemia	anaemia	NN
cord-023168-cd7adns8	719	20	and	and	CC
cord-023168-cd7adns8	719	21	erythropoietic	erythropoietic	NN
cord-023168-cd7adns8	719	22	drive	drive	NN
cord-023168-cd7adns8	719	23	.	.	.
cord-023168-cd7adns8	720	1	However	however	RB
cord-023168-cd7adns8	720	2	,	,	,
cord-023168-cd7adns8	720	3	in	in	IN
cord-023168-cd7adns8	720	4	many	many	JJ
cord-023168-cd7adns8	720	5	low	low	JJ
cord-023168-cd7adns8	720	6	-	-	HYPH
cord-023168-cd7adns8	720	7	income	income	NN
cord-023168-cd7adns8	720	8	settings	setting	NNS
cord-023168-cd7adns8	720	9	blood	blood	NN
cord-023168-cd7adns8	720	10	supplies	supply	NNS
cord-023168-cd7adns8	720	11	are	be	VBP
cord-023168-cd7adns8	720	12	inadequate	inadequate	JJ
cord-023168-cd7adns8	720	13	and	and	CC
cord-023168-cd7adns8	720	14	many	many	JJ
cord-023168-cd7adns8	720	15	thalassaemic	thalassaemic	JJ
cord-023168-cd7adns8	720	16	patients	patient	NNS
cord-023168-cd7adns8	720	17	are	be	VBP
cord-023168-cd7adns8	720	18	chronically	chronically	RB
cord-023168-cd7adns8	720	19	under	under	RB
cord-023168-cd7adns8	720	20	-	-	HYPH
cord-023168-cd7adns8	720	21	transfused	transfuse	VBN
cord-023168-cd7adns8	721	1	(	(	-LRB-
cord-023168-cd7adns8	721	2	Table	table	NN
cord-023168-cd7adns8	721	3	65	65	CD
cord-023168-cd7adns8	721	4	.7	.7	NFP
cord-023168-cd7adns8	721	5	)	)	-RRB-
cord-023168-cd7adns8	721	6	.	.	.
cord-023168-cd7adns8	722	1	165	165	CD
cord-023168-cd7adns8	722	2	Transfusion	transfusion	NN
cord-023168-cd7adns8	722	3	frequency	frequency	NN
cord-023168-cd7adns8	722	4	should	should	MD
cord-023168-cd7adns8	722	5	be	be	VB
cord-023168-cd7adns8	722	6	guided	guide	VBN
cord-023168-cd7adns8	722	7	by	by	IN
cord-023168-cd7adns8	722	8	clinical	clinical	JJ
cord-023168-cd7adns8	722	9	symptoms	symptom	NNS
cord-023168-cd7adns8	722	10	and	and	CC
cord-023168-cd7adns8	722	11	signs	sign	NNS
cord-023168-cd7adns8	722	12	such	such	JJ
cord-023168-cd7adns8	722	13	as	as	IN
cord-023168-cd7adns8	722	14	poor	poor	JJ
cord-023168-cd7adns8	722	15	growth	growth	NN
cord-023168-cd7adns8	722	16	and	and	CC
cord-023168-cd7adns8	722	17	facial	facial	JJ
cord-023168-cd7adns8	722	18	or	or	CC
cord-023168-cd7adns8	722	19	other	other	JJ
cord-023168-cd7adns8	722	20	bone	bone	NN
cord-023168-cd7adns8	722	21	abnormalities	abnormality	NNS
cord-023168-cd7adns8	722	22	,	,	,
cord-023168-cd7adns8	722	23	and	and	CC
cord-023168-cd7adns8	722	24	should	should	MD
cord-023168-cd7adns8	722	25	take	take	VB
cord-023168-cd7adns8	722	26	into	into	IN
cord-023168-cd7adns8	722	27	account	account	NN
cord-023168-cd7adns8	722	28	any	any	DT
cord-023168-cd7adns8	722	29	potential	potential	JJ
cord-023168-cd7adns8	722	30	disease	disease	NN
cord-023168-cd7adns8	722	31	-	-	HYPH
cord-023168-cd7adns8	722	32	modifying	modify	VBG
cord-023168-cd7adns8	722	33	comorbidities	comorbiditie	NNS
cord-023168-cd7adns8	722	34	.	.	.
cord-023168-cd7adns8	723	1	156	156	CD
cord-023168-cd7adns8	724	1	Although	although	IN
cord-023168-cd7adns8	724	2	the	the	DT
cord-023168-cd7adns8	724	3	decision	decision	NN
cord-023168-cd7adns8	724	4	to	to	TO
cord-023168-cd7adns8	724	5	transfuse	transfuse	VB
cord-023168-cd7adns8	724	6	should	should	MD
cord-023168-cd7adns8	724	7	not	not	RB
cord-023168-cd7adns8	724	8	be	be	VB
cord-023168-cd7adns8	724	9	based	base	VBN
cord-023168-cd7adns8	724	10	purely	purely	RB
cord-023168-cd7adns8	724	11	on	on	IN
cord-023168-cd7adns8	724	12	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	724	13	levels	level	NNS
cord-023168-cd7adns8	724	14	,	,	,
cord-023168-cd7adns8	724	15	a	a	DT
cord-023168-cd7adns8	724	16	value	value	NN
cord-023168-cd7adns8	724	17	of	of	IN
cord-023168-cd7adns8	724	18	<	<	$
cord-023168-cd7adns8	724	19	70	70	CD
cord-023168-cd7adns8	724	20	g	g	NN
cord-023168-cd7adns8	724	21	/	/	SYM
cord-023168-cd7adns8	724	22	L	L	NNP
cord-023168-cd7adns8	724	23	is	be	VBZ
cord-023168-cd7adns8	724	24	often	often	RB
cord-023168-cd7adns8	724	25	used	use	VBN
cord-023168-cd7adns8	724	26	as	as	IN
cord-023168-cd7adns8	724	27	a	a	DT
cord-023168-cd7adns8	724	28	trigger	trigger	NN
cord-023168-cd7adns8	724	29	for	for	IN
cord-023168-cd7adns8	724	30	regular	regular	JJ
cord-023168-cd7adns8	724	31	transfusions	transfusion	NNS
cord-023168-cd7adns8	724	32	.	.	.
cord-023168-cd7adns8	725	1	To	to	TO
cord-023168-cd7adns8	725	2	prevent	prevent	VB
cord-023168-cd7adns8	725	3	alloimmunization	alloimmunization	NN
cord-023168-cd7adns8	725	4	,	,	,
cord-023168-cd7adns8	725	5	extended	extended	JJ
cord-023168-cd7adns8	725	6	red	red	JJ
cord-023168-cd7adns8	725	7	cell	cell	NN
cord-023168-cd7adns8	725	8	antigen	antigen	NN
cord-023168-cd7adns8	725	9	typing	type	VBG
cord-023168-cd7adns8	725	10	for	for	IN
cord-023168-cd7adns8	725	11	C	C	NNP
cord-023168-cd7adns8	725	12	,	,	,
cord-023168-cd7adns8	725	13	E	E	NNP
cord-023168-cd7adns8	725	14	and	and	CC
cord-023168-cd7adns8	725	15	Kell	Kell	NNP
cord-023168-cd7adns8	725	16	in	in	IN
cord-023168-cd7adns8	725	17	addition	addition	NN
cord-023168-cd7adns8	725	18	to	to	IN
cord-023168-cd7adns8	725	19	ABO	ABO	NNP
cord-023168-cd7adns8	725	20	and	and	CC
cord-023168-cd7adns8	725	21	Rh(D	Rh(D	NNP
cord-023168-cd7adns8	725	22	)	)	-RRB-
cord-023168-cd7adns8	726	1	typing	typing	NN
cord-023168-cd7adns8	726	2	should	should	MD
cord-023168-cd7adns8	726	3	be	be	VB
cord-023168-cd7adns8	726	4	carried	carry	VBN
cord-023168-cd7adns8	726	5	out	out	RP
cord-023168-cd7adns8	726	6	prior	prior	RB
cord-023168-cd7adns8	726	7	to	to	IN
cord-023168-cd7adns8	726	8	the	the	DT
cord-023168-cd7adns8	726	9	first	first	JJ
cord-023168-cd7adns8	726	10	transfusion	transfusion	NN
cord-023168-cd7adns8	726	11	,	,	,
cord-023168-cd7adns8	726	12	and	and	CC
cord-023168-cd7adns8	726	13	before	before	IN
cord-023168-cd7adns8	726	14	each	each	DT
cord-023168-cd7adns8	726	15	transfusion	transfusion	NN
cord-023168-cd7adns8	726	16	,	,	,
cord-023168-cd7adns8	726	17	full	full	JJ
cord-023168-cd7adns8	726	18	cross	cross	NN
cord-023168-cd7adns8	726	19	-	-	JJ
cord-023168-cd7adns8	726	20	match	match	NN
cord-023168-cd7adns8	726	21	and	and	CC
cord-023168-cd7adns8	726	22	screening	screening	NN
cord-023168-cd7adns8	726	23	for	for	IN
cord-023168-cd7adns8	726	24	new	new	JJ
cord-023168-cd7adns8	726	25	antibodies	antibody	NNS
cord-023168-cd7adns8	726	26	should	should	MD
cord-023168-cd7adns8	726	27	be	be	VB
cord-023168-cd7adns8	726	28	undertaken	undertake	VBN
cord-023168-cd7adns8	726	29	.	.	.
cord-023168-cd7adns8	727	1	166	166	CD
cord-023168-cd7adns8	728	1	The	the	DT
cord-023168-cd7adns8	728	2	risk	risk	NN
cord-023168-cd7adns8	728	3	of	of	IN
cord-023168-cd7adns8	728	4	alloimmunization	alloimmunization	NN
cord-023168-cd7adns8	728	5	appears	appear	VBZ
cord-023168-cd7adns8	728	6	to	to	TO
cord-023168-cd7adns8	728	7	be	be	VB
cord-023168-cd7adns8	728	8	greater	great	JJR
cord-023168-cd7adns8	728	9	in	in	IN
cord-023168-cd7adns8	728	10	patients	patient	NNS
cord-023168-cd7adns8	728	11	who	who	WP
cord-023168-cd7adns8	728	12	begin	begin	VBP
cord-023168-cd7adns8	728	13	transfusion	transfusion	NN
cord-023168-cd7adns8	728	14	therapy	therapy	NN
cord-023168-cd7adns8	728	15	after	after	IN
cord-023168-cd7adns8	728	16	the	the	DT
cord-023168-cd7adns8	728	17	first	first	JJ
cord-023168-cd7adns8	728	18	few	few	JJ
cord-023168-cd7adns8	728	19	years	year	NNS
cord-023168-cd7adns8	728	20	of	of	IN
cord-023168-cd7adns8	728	21	life	life	NN
cord-023168-cd7adns8	728	22	.	.	.
cord-023168-cd7adns8	729	1	128	128	CD
cord-023168-cd7adns8	729	2	Development	Development	NNP
cord-023168-cd7adns8	729	3	of	of	IN
cord-023168-cd7adns8	729	4	alloantibodies	alloantibody	NNS
cord-023168-cd7adns8	729	5	and	and	CC
cord-023168-cd7adns8	729	6	autoantibodies	autoantibody	NNS
cord-023168-cd7adns8	729	7	may	may	MD
cord-023168-cd7adns8	729	8	result	result	VB
cord-023168-cd7adns8	729	9	in	in	IN
cord-023168-cd7adns8	729	10	increased	increase	VBN
cord-023168-cd7adns8	729	11	transfusion	transfusion	NN
cord-023168-cd7adns8	729	12	requirements	requirement	NNS
cord-023168-cd7adns8	729	13	or	or	CC
cord-023168-cd7adns8	729	14	haemolysis	haemolysis	NN
cord-023168-cd7adns8	729	15	.	.	.
cord-023168-cd7adns8	730	1	Use	use	NN
cord-023168-cd7adns8	730	2	of	of	IN
cord-023168-cd7adns8	730	3	leukodepletion	leukodepletion	NN
cord-023168-cd7adns8	730	4	techniques	technique	NNS
cord-023168-cd7adns8	730	5	can	can	MD
cord-023168-cd7adns8	730	6	result	result	VB
cord-023168-cd7adns8	730	7	in	in	IN
cord-023168-cd7adns8	730	8	less	less	JJR
cord-023168-cd7adns8	730	9	alloimmunization	alloimmunization	NN
cord-023168-cd7adns8	730	10	and	and	CC
cord-023168-cd7adns8	730	11	fewer	few	JJR
cord-023168-cd7adns8	730	12	febrile	febrile	JJ
cord-023168-cd7adns8	730	13	transfusion	transfusion	NN
cord-023168-cd7adns8	730	14	reactions	reaction	NNS
cord-023168-cd7adns8	730	15	.	.	.
cord-023168-cd7adns8	731	1	Since	since	IN
cord-023168-cd7adns8	731	2	storage	storage	NN
cord-023168-cd7adns8	731	3	of	of	IN
cord-023168-cd7adns8	731	4	red	red	JJ
cord-023168-cd7adns8	731	5	cells	cell	NNS
cord-023168-cd7adns8	731	6	in	in	IN
cord-023168-cd7adns8	731	7	anticoagulant	anticoagulant	JJ
cord-023168-cd7adns8	731	8	solutions	solution	NNS
cord-023168-cd7adns8	731	9	may	may	MD
cord-023168-cd7adns8	731	10	decrease	decrease	VB
cord-023168-cd7adns8	731	11	their	-PRON-	PRP$
cord-023168-cd7adns8	731	12	efficacy	efficacy	NN
cord-023168-cd7adns8	731	13	,	,	,
cord-023168-cd7adns8	731	14	the	the	DT
cord-023168-cd7adns8	731	15	use	use	NN
cord-023168-cd7adns8	731	16	of	of	IN
cord-023168-cd7adns8	731	17	blood	blood	NN
cord-023168-cd7adns8	731	18	that	that	WDT
cord-023168-cd7adns8	731	19	has	have	VBZ
cord-023168-cd7adns8	731	20	been	be	VBN
cord-023168-cd7adns8	731	21	stored	store	VBN
cord-023168-cd7adns8	731	22	for	for	IN
cord-023168-cd7adns8	731	23	less	less	JJR
cord-023168-cd7adns8	731	24	than	than	IN
cord-023168-cd7adns8	731	25	7	7	CD
cord-023168-cd7adns8	731	26	-	-	SYM
cord-023168-cd7adns8	731	27	10	10	CD
cord-023168-cd7adns8	731	28	days	day	NNS
cord-023168-cd7adns8	731	29	may	may	MD
cord-023168-cd7adns8	731	30	be	be	VB
cord-023168-cd7adns8	731	31	beneficial	beneficial	JJ
cord-023168-cd7adns8	731	32	for	for	IN
cord-023168-cd7adns8	731	33	patients	patient	NNS
cord-023168-cd7adns8	731	34	who	who	WP
cord-023168-cd7adns8	731	35	require	require	VBP
cord-023168-cd7adns8	731	36	frequent	frequent	JJ
cord-023168-cd7adns8	731	37	transfusions	transfusion	NNS
cord-023168-cd7adns8	731	38	.	.	.
cord-023168-cd7adns8	732	1	The	the	DT
cord-023168-cd7adns8	732	2	use	use	NN
cord-023168-cd7adns8	732	3	of	of	IN
cord-023168-cd7adns8	732	4	1st	1st	JJ
cord-023168-cd7adns8	732	5	-	-	HYPH
cord-023168-cd7adns8	732	6	degree	degree	NN
cord-023168-cd7adns8	732	7	relatives	relative	NNS
cord-023168-cd7adns8	732	8	as	as	IN
cord-023168-cd7adns8	732	9	blood	blood	NN
cord-023168-cd7adns8	732	10	donors	donor	NNS
cord-023168-cd7adns8	732	11	should	should	MD
cord-023168-cd7adns8	732	12	be	be	VB
cord-023168-cd7adns8	732	13	discouraged	discourage	VBN
cord-023168-cd7adns8	732	14	,	,	,
cord-023168-cd7adns8	732	15	especially	especially	RB
cord-023168-cd7adns8	732	16	if	if	IN
cord-023168-cd7adns8	732	17	the	the	DT
cord-023168-cd7adns8	732	18	patient	patient	NN
cord-023168-cd7adns8	732	19	is	be	VBZ
cord-023168-cd7adns8	732	20	a	a	DT
cord-023168-cd7adns8	732	21	candidate	candidate	NN
cord-023168-cd7adns8	732	22	for	for	IN
cord-023168-cd7adns8	732	23	stem	stem	NN
cord-023168-cd7adns8	732	24	cell	cell	NN
cord-023168-cd7adns8	732	25	transplant	transplant	NN
cord-023168-cd7adns8	732	26	.	.	.
cord-023168-cd7adns8	733	1	Patients	patient	NNS
cord-023168-cd7adns8	733	2	with	with	IN
cord-023168-cd7adns8	733	3	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	733	4	major	major	JJ
cord-023168-cd7adns8	733	5	need	need	VBP
cord-023168-cd7adns8	733	6	lifelong	lifelong	JJ
cord-023168-cd7adns8	733	7	regular	regular	JJ
cord-023168-cd7adns8	733	8	blood	blood	NN
cord-023168-cd7adns8	733	9	transfusions	transfusion	NNS
cord-023168-cd7adns8	733	10	,	,	,
cord-023168-cd7adns8	733	11	15	15	CD
cord-023168-cd7adns8	733	12	mL	ml	NN
cord-023168-cd7adns8	733	13	/	/	SYM
cord-023168-cd7adns8	733	14	kg	kg	NN
cord-023168-cd7adns8	733	15	per	per	IN
cord-023168-cd7adns8	733	16	month	month	NN
cord-023168-cd7adns8	733	17	or	or	CC
cord-023168-cd7adns8	733	18	1	1	CD
cord-023168-cd7adns8	733	19	-	-	SYM
cord-023168-cd7adns8	733	20	2	2	CD
cord-023168-cd7adns8	733	21	units	unit	NNS
cord-023168-cd7adns8	733	22	of	of	IN
cord-023168-cd7adns8	733	23	blood	blood	NN
cord-023168-cd7adns8	733	24	every	every	DT
cord-023168-cd7adns8	733	25	2	2	CD
cord-023168-cd7adns8	733	26	-	-	SYM
cord-023168-cd7adns8	733	27	5	5	CD
cord-023168-cd7adns8	733	28	weeks	week	NNS
cord-023168-cd7adns8	733	29	,	,	,
cord-023168-cd7adns8	733	30	to	to	TO
cord-023168-cd7adns8	733	31	maintain	maintain	VB
cord-023168-cd7adns8	733	32	the	the	DT
cord-023168-cd7adns8	733	33	pre	pre	JJ
cord-023168-cd7adns8	733	34	-	-	JJ
cord-023168-cd7adns8	733	35	transfusion	transfusion	JJ
cord-023168-cd7adns8	733	36	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	733	37	level	level	NN
cord-023168-cd7adns8	733	38	above	above	IN
cord-023168-cd7adns8	733	39	90	90	CD
cord-023168-cd7adns8	733	40	-	-	SYM
cord-023168-cd7adns8	733	41	105	105	CD
cord-023168-cd7adns8	733	42	g	g	NN
cord-023168-cd7adns8	733	43	/	/	SYM
cord-023168-cd7adns8	733	44	L.	L.	NNP
cord-023168-cd7adns8	734	1	The	the	DT
cord-023168-cd7adns8	734	2	clinical	clinical	JJ
cord-023168-cd7adns8	734	3	benefits	benefit	NNS
cord-023168-cd7adns8	734	4	of	of	IN
cord-023168-cd7adns8	734	5	this	this	DT
cord-023168-cd7adns8	734	6	regular	regular	JJ
cord-023168-cd7adns8	734	7	transfusion	transfusion	NN
cord-023168-cd7adns8	734	8	programme	programme	NN
cord-023168-cd7adns8	734	9	include	include	VBP
cord-023168-cd7adns8	734	10	normal	normal	JJ
cord-023168-cd7adns8	734	11	growth	growth	NN
cord-023168-cd7adns8	734	12	,	,	,
cord-023168-cd7adns8	734	13	suppression	suppression	NN
cord-023168-cd7adns8	734	14	of	of	IN
cord-023168-cd7adns8	734	15	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	734	16	and	and	CC
cord-023168-cd7adns8	734	17	bone	bone	NN
cord-023168-cd7adns8	734	18	marrow	marrow	NN
cord-023168-cd7adns8	734	19	expansion	expansion	NN
cord-023168-cd7adns8	734	20	,	,	,
cord-023168-cd7adns8	734	21	reduced	reduce	VBN
cord-023168-cd7adns8	734	22	hepatosplenomegaly	hepatosplenomegaly	NNP
cord-023168-cd7adns8	734	23	and	and	CC
cord-023168-cd7adns8	734	24	an	an	DT
cord-023168-cd7adns8	734	25	overall	overall	JJ
cord-023168-cd7adns8	734	26	sense	sense	NN
cord-023168-cd7adns8	734	27	of	of	IN
cord-023168-cd7adns8	734	28	wellbeing	wellbeing	NN
cord-023168-cd7adns8	734	29	,	,	,
cord-023168-cd7adns8	734	30	which	which	WDT
cord-023168-cd7adns8	734	31	allows	allow	VBZ
cord-023168-cd7adns8	734	32	normal	normal	JJ
cord-023168-cd7adns8	734	33	age	age	NN
cord-023168-cd7adns8	734	34	-	-	HYPH
cord-023168-cd7adns8	734	35	appropriate	appropriate	JJ
cord-023168-cd7adns8	734	36	activities	activity	NNS
cord-023168-cd7adns8	734	37	.	.	.
cord-023168-cd7adns8	735	1	A	a	DT
cord-023168-cd7adns8	735	2	higher	high	JJR
cord-023168-cd7adns8	735	3	target	target	NN
cord-023168-cd7adns8	735	4	pretransfusion	pretransfusion	NN
cord-023168-cd7adns8	735	5	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	735	6	level	level	NN
cord-023168-cd7adns8	735	7	of	of	IN
cord-023168-cd7adns8	735	8	110	110	CD
cord-023168-cd7adns8	735	9	-	-	SYM
cord-023168-cd7adns8	735	10	120	120	CD
cord-023168-cd7adns8	735	11	g	g	NN
cord-023168-cd7adns8	735	12	/	/	SYM
cord-023168-cd7adns8	735	13	L	L	NNP
cord-023168-cd7adns8	735	14	may	may	MD
cord-023168-cd7adns8	735	15	be	be	VB
cord-023168-cd7adns8	735	16	necessary	necessary	JJ
cord-023168-cd7adns8	735	17	for	for	IN
cord-023168-cd7adns8	735	18	patients	patient	NNS
cord-023168-cd7adns8	735	19	with	with	IN
cord-023168-cd7adns8	735	20	heart	heart	NN
cord-023168-cd7adns8	735	21	disease	disease	NN
cord-023168-cd7adns8	735	22	or	or	CC
cord-023168-cd7adns8	735	23	other	other	JJ
cord-023168-cd7adns8	735	24	medical	medical	JJ
cord-023168-cd7adns8	735	25	conditions	condition	NNS
cord-023168-cd7adns8	735	26	and	and	CC
cord-023168-cd7adns8	735	27	for	for	IN
cord-023168-cd7adns8	735	28	those	those	DT
cord-023168-cd7adns8	735	29	patients	patient	NNS
cord-023168-cd7adns8	735	30	who	who	WP
cord-023168-cd7adns8	735	31	do	do	VBP
cord-023168-cd7adns8	735	32	not	not	RB
cord-023168-cd7adns8	735	33	achieve	achieve	VB
cord-023168-cd7adns8	735	34	adequate	adequate	JJ
cord-023168-cd7adns8	735	35	suppression	suppression	NN
cord-023168-cd7adns8	735	36	of	of	IN
cord-023168-cd7adns8	735	37	bone	bone	NN
cord-023168-cd7adns8	735	38	marrow	marrow	NN
cord-023168-cd7adns8	735	39	activity	activity	NN
cord-023168-cd7adns8	735	40	at	at	IN
cord-023168-cd7adns8	735	41	the	the	DT
cord-023168-cd7adns8	735	42	lower	low	JJR
cord-023168-cd7adns8	735	43	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	735	44	level	level	NN
cord-023168-cd7adns8	735	45	.	.	.
cord-023168-cd7adns8	736	1	Shorter	short	JJR
cord-023168-cd7adns8	736	2	intervals	interval	NNS
cord-023168-cd7adns8	736	3	between	between	IN
cord-023168-cd7adns8	736	4	transfusions	transfusion	NNS
cord-023168-cd7adns8	736	5	may	may	MD
cord-023168-cd7adns8	736	6	reduce	reduce	VB
cord-023168-cd7adns8	736	7	overall	overall	JJ
cord-023168-cd7adns8	736	8	blood	blood	NN
cord-023168-cd7adns8	736	9	requirements	requirement	NNS
cord-023168-cd7adns8	736	10	but	but	CC
cord-023168-cd7adns8	736	11	need	need	VBP
cord-023168-cd7adns8	736	12	to	to	TO
cord-023168-cd7adns8	736	13	be	be	VB
cord-023168-cd7adns8	736	14	balanced	balance	VBN
cord-023168-cd7adns8	736	15	against	against	IN
cord-023168-cd7adns8	736	16	the	the	DT
cord-023168-cd7adns8	736	17	patient	patient	NN
cord-023168-cd7adns8	736	18	's	's	POS
cord-023168-cd7adns8	736	19	work	work	NN
cord-023168-cd7adns8	736	20	or	or	CC
cord-023168-cd7adns8	736	21	school	school	NN
cord-023168-cd7adns8	736	22	schedule	schedule	NN
cord-023168-cd7adns8	736	23	and	and	CC
cord-023168-cd7adns8	736	24	other	other	JJ
cord-023168-cd7adns8	736	25	lifestyle	lifestyle	NN
cord-023168-cd7adns8	736	26	issues	issue	NNS
cord-023168-cd7adns8	736	27	.	.	.
cord-023168-cd7adns8	737	1	Iron	iron	NN
cord-023168-cd7adns8	737	2	chelation	chelation	NN
cord-023168-cd7adns8	737	3	therapy	therapy	NN
cord-023168-cd7adns8	737	4	167	167	CD
cord-023168-cd7adns8	737	5	,	,	,
cord-023168-cd7adns8	737	6	168	168	CD
cord-023168-cd7adns8	737	7	has	have	VBZ
cord-023168-cd7adns8	737	8	improved	improve	VBN
cord-023168-cd7adns8	737	9	survival	survival	NN
cord-023168-cd7adns8	737	10	rates	rate	NNS
cord-023168-cd7adns8	737	11	for	for	IN
cord-023168-cd7adns8	737	12	thalassaemic	thalassaemic	JJ
cord-023168-cd7adns8	737	13	patients	patient	NNS
cord-023168-cd7adns8	737	14	,	,	,
cord-023168-cd7adns8	737	15	and	and	CC
cord-023168-cd7adns8	737	16	prevented	prevent	VBD
cord-023168-cd7adns8	737	17	hepatic	hepatic	JJ
cord-023168-cd7adns8	737	18	fibrosis	fibrosis	NN
cord-023168-cd7adns8	737	19	and	and	CC
cord-023168-cd7adns8	737	20	ironinduced	ironinduced	JJ
cord-023168-cd7adns8	737	21	cardiac	cardiac	JJ
cord-023168-cd7adns8	737	22	disease	disease	NN
cord-023168-cd7adns8	737	23	;	;	:
cord-023168-cd7adns8	737	24	most	most	JJS
cord-023168-cd7adns8	737	25	patients	patient	NNS
cord-023168-cd7adns8	737	26	who	who	WP
cord-023168-cd7adns8	737	27	are	be	VBP
cord-023168-cd7adns8	737	28	compliant	compliant	JJ
cord-023168-cd7adns8	737	29	with	with	IN
cord-023168-cd7adns8	737	30	chelation	chelation	NN
cord-023168-cd7adns8	737	31	therapy	therapy	NN
cord-023168-cd7adns8	737	32	have	have	VBP
cord-023168-cd7adns8	737	33	normal	normal	JJ
cord-023168-cd7adns8	737	34	growth	growth	NN
cord-023168-cd7adns8	737	35	and	and	CC
cord-023168-cd7adns8	737	36	sexual	sexual	JJ
cord-023168-cd7adns8	737	37	development	development	NN
cord-023168-cd7adns8	737	38	.	.	.
cord-023168-cd7adns8	738	1	Iron	iron	NN
cord-023168-cd7adns8	738	2	chelators	chelator	NNS
cord-023168-cd7adns8	738	3	(	(	-LRB-
cord-023168-cd7adns8	738	4	Box	Box	NNP
cord-023168-cd7adns8	738	5	65.16	65.16	CD
cord-023168-cd7adns8	738	6	)	)	-RRB-
cord-023168-cd7adns8	738	7	are	be	VBP
cord-023168-cd7adns8	738	8	usually	usually	RB
cord-023168-cd7adns8	738	9	initiated	initiate	VBN
cord-023168-cd7adns8	738	10	in	in	IN
cord-023168-cd7adns8	738	11	children	child	NNS
cord-023168-cd7adns8	738	12	over	over	IN
cord-023168-cd7adns8	738	13	2	2	CD
cord-023168-cd7adns8	738	14	years	year	NNS
cord-023168-cd7adns8	738	15	who	who	WP
cord-023168-cd7adns8	738	16	have	have	VBP
cord-023168-cd7adns8	738	17	received	receive	VBN
cord-023168-cd7adns8	738	18	10	10	CD
cord-023168-cd7adns8	738	19	units	unit	NNS
cord-023168-cd7adns8	738	20	of	of	IN
cord-023168-cd7adns8	738	21	blood	blood	NN
cord-023168-cd7adns8	738	22	and/or	and/or	CC
cord-023168-cd7adns8	738	23	have	have	VB
cord-023168-cd7adns8	738	24	a	a	DT
cord-023168-cd7adns8	738	25	steady	steady	JJ
cord-023168-cd7adns8	738	26	-	-	HYPH
cord-023168-cd7adns8	738	27	state	state	NN
cord-023168-cd7adns8	738	28	serum	serum	NN
cord-023168-cd7adns8	738	29	ferritin	ferritin	NN
cord-023168-cd7adns8	738	30	level	level	NN
cord-023168-cd7adns8	738	31	above	above	IN
cord-023168-cd7adns8	738	32	1000	1000	CD
cord-023168-cd7adns8	738	33	ng	ng	NN
cord-023168-cd7adns8	738	34	/	/	SYM
cord-023168-cd7adns8	738	35	mL	ml	NN
cord-023168-cd7adns8	738	36	on	on	RP
cord-023168-cd7adns8	738	37	at	at	RB
cord-023168-cd7adns8	738	38	least	least	RBS
cord-023168-cd7adns8	738	39	two	two	CD
cord-023168-cd7adns8	738	40	occasions	occasion	NNS
cord-023168-cd7adns8	738	41	.	.	.
cord-023168-cd7adns8	739	1	This	this	DT
cord-023168-cd7adns8	739	2	level	level	NN
cord-023168-cd7adns8	739	3	of	of	IN
cord-023168-cd7adns8	739	4	iron	iron	NN
cord-023168-cd7adns8	739	5	overload	overload	NN
cord-023168-cd7adns8	739	6	typically	typically	RB
cord-023168-cd7adns8	739	7	occurs	occur	VBZ
cord-023168-cd7adns8	739	8	after	after	IN
cord-023168-cd7adns8	739	9	1	1	CD
cord-023168-cd7adns8	739	10	-	-	SYM
cord-023168-cd7adns8	739	11	2	2	CD
cord-023168-cd7adns8	739	12	years	year	NNS
cord-023168-cd7adns8	739	13	of	of	IN
cord-023168-cd7adns8	739	14	transfusions	transfusion	NNS
cord-023168-cd7adns8	739	15	.	.	.
cord-023168-cd7adns8	740	1	Desferrioxamine	Desferrioxamine	NNP
cord-023168-cd7adns8	740	2	is	be	VBZ
cord-023168-cd7adns8	740	3	started	start	VBN
cord-023168-cd7adns8	740	4	at	at	IN
cord-023168-cd7adns8	740	5	25	25	CD
cord-023168-cd7adns8	740	6	-	-	SYM
cord-023168-cd7adns8	740	7	30	30	CD
cord-023168-cd7adns8	740	8	mg	mg	NNP
cord-023168-cd7adns8	740	9	/	/	SYM
cord-023168-cd7adns8	740	10	kg	kg	NN
cord-023168-cd7adns8	740	11	per	per	IN
cord-023168-cd7adns8	740	12	day	day	NN
cord-023168-cd7adns8	740	13	in	in	IN
cord-023168-cd7adns8	740	14	these	these	DT
cord-023168-cd7adns8	740	15	children	child	NNS
cord-023168-cd7adns8	740	16	initially	initially	RB
cord-023168-cd7adns8	740	17	,	,	,
cord-023168-cd7adns8	740	18	to	to	TO
cord-023168-cd7adns8	740	19	avoid	avoid	VB
cord-023168-cd7adns8	740	20	toxicity	toxicity	NN
cord-023168-cd7adns8	740	21	due	due	IN
cord-023168-cd7adns8	740	22	to	to	IN
cord-023168-cd7adns8	740	23	over	over	IN
cord-023168-cd7adns8	740	24	chelation	chelation	NN
cord-023168-cd7adns8	740	25	.	.	.
cord-023168-cd7adns8	741	1	Marked	marked	JJ
cord-023168-cd7adns8	741	2	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	741	3	,	,	,
cord-023168-cd7adns8	741	4	often	often	RB
cord-023168-cd7adns8	741	5	treated	treat	VBN
cord-023168-cd7adns8	741	6	with	with	IN
cord-023168-cd7adns8	741	7	splenectomy	splenectomy	NN
cord-023168-cd7adns8	741	8	,	,	,
cord-023168-cd7adns8	741	9	was	be	VBD
cord-023168-cd7adns8	741	10	common	common	JJ
cord-023168-cd7adns8	741	11	in	in	IN
cord-023168-cd7adns8	741	12	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	741	13	patients	patient	NNS
cord-023168-cd7adns8	741	14	before	before	IN
cord-023168-cd7adns8	741	15	the	the	DT
cord-023168-cd7adns8	741	16	advent	advent	NN
cord-023168-cd7adns8	741	17	of	of	IN
cord-023168-cd7adns8	741	18	regular	regular	JJ
cord-023168-cd7adns8	741	19	transfusion	transfusion	NN
cord-023168-cd7adns8	741	20	programmes	programme	NNS
cord-023168-cd7adns8	741	21	.	.	.
cord-023168-cd7adns8	742	1	Severe	severe	JJ
cord-023168-cd7adns8	742	2	haemolysis	haemolysis	NN
cord-023168-cd7adns8	742	3	in	in	IN
cord-023168-cd7adns8	742	4	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	742	5	is	be	VBZ
cord-023168-cd7adns8	742	6	related	relate	VBN
cord-023168-cd7adns8	742	7	to	to	IN
cord-023168-cd7adns8	742	8	a	a	DT
cord-023168-cd7adns8	742	9	hyperactive	hyperactive	JJ
cord-023168-cd7adns8	742	10	spleen	spleen	NN
cord-023168-cd7adns8	742	11	,	,	,
cord-023168-cd7adns8	742	12	which	which	WDT
cord-023168-cd7adns8	742	13	aggravates	aggravate	VBZ
cord-023168-cd7adns8	742	14	anaemia	anaemia	NN
cord-023168-cd7adns8	742	15	and	and	CC
cord-023168-cd7adns8	742	16	can	can	MD
cord-023168-cd7adns8	742	17	increase	increase	VB
cord-023168-cd7adns8	742	18	transfusion	transfusion	NN
cord-023168-cd7adns8	742	19	requirements	requirement	NNS
cord-023168-cd7adns8	742	20	.	.	.
cord-023168-cd7adns8	743	1	Although	although	IN
cord-023168-cd7adns8	743	2	early	early	RB
cord-023168-cd7adns8	743	3	The	the	DT
cord-023168-cd7adns8	743	4	initiation	initiation	NN
cord-023168-cd7adns8	743	5	of	of	IN
cord-023168-cd7adns8	743	6	regular	regular	JJ
cord-023168-cd7adns8	743	7	transfusion	transfusion	NN
cord-023168-cd7adns8	743	8	therapy	therapy	NN
cord-023168-cd7adns8	743	9	for	for	IN
cord-023168-cd7adns8	743	10	severe	severe	JJ
cord-023168-cd7adns8	743	11	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	743	12	usually	usually	RB
cord-023168-cd7adns8	743	13	occurs	occur	VBZ
cord-023168-cd7adns8	743	14	in	in	IN
cord-023168-cd7adns8	743	15	the	the	DT
cord-023168-cd7adns8	743	16	first	first	JJ
cord-023168-cd7adns8	743	17	2	2	CD
cord-023168-cd7adns8	743	18	years	year	NNS
cord-023168-cd7adns8	743	19	of	of	IN
cord-023168-cd7adns8	743	20	life	life	NN
cord-023168-cd7adns8	743	21	.	.	.
cord-023168-cd7adns8	744	1	Some	some	DT
cord-023168-cd7adns8	744	2	patients	patient	NNS
cord-023168-cd7adns8	744	3	with	with	IN
cord-023168-cd7adns8	744	4	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	744	5	intermedia	intermedia	NN
cord-023168-cd7adns8	744	6	who	who	WP
cord-023168-cd7adns8	744	7	only	only	RB
cord-023168-cd7adns8	744	8	need	need	VBP
cord-023168-cd7adns8	744	9	sporadic	sporadic	JJ
cord-023168-cd7adns8	744	10	transfusions	transfusion	NNS
cord-023168-cd7adns8	744	11	in	in	IN
cord-023168-cd7adns8	744	12	the	the	DT
cord-023168-cd7adns8	744	13	first	first	JJ
cord-023168-cd7adns8	744	14	two	two	CD
cord-023168-cd7adns8	744	15	decades	decade	NNS
cord-023168-cd7adns8	744	16	of	of	IN
cord-023168-cd7adns8	744	17	life	life	NN
cord-023168-cd7adns8	744	18	may	may	MD
cord-023168-cd7adns8	744	19	later	later	RB
cord-023168-cd7adns8	744	20	need	need	VB
cord-023168-cd7adns8	744	21	regular	regular	JJ
cord-023168-cd7adns8	744	22	transfusions	transfusion	NNS
cord-023168-cd7adns8	744	23	because	because	IN
cord-023168-cd7adns8	744	24	of	of	IN
cord-023168-cd7adns8	744	25	a	a	DT
cord-023168-cd7adns8	744	26	falling	fall	VBG
cord-023168-cd7adns8	744	27	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	744	28	level	level	NN
cord-023168-cd7adns8	744	29	or	or	CC
cord-023168-cd7adns8	744	30	the	the	DT
cord-023168-cd7adns8	744	31	development	development	NN
cord-023168-cd7adns8	744	32	of	of	IN
cord-023168-cd7adns8	744	33	serious	serious	JJ
cord-023168-cd7adns8	744	34	complications	complication	NNS
cord-023168-cd7adns8	744	35	.	.	.
cord-023168-cd7adns8	745	1	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	745	2	should	should	MD
cord-023168-cd7adns8	745	3	be	be	VB
cord-023168-cd7adns8	745	4	monitored	monitor	VBN
cord-023168-cd7adns8	745	5	to	to	TO
cord-023168-cd7adns8	745	6	assess	assess	VB
cord-023168-cd7adns8	745	7	the	the	DT
cord-023168-cd7adns8	745	8	rate	rate	NN
cord-023168-cd7adns8	745	9	of	of	IN
cord-023168-cd7adns8	745	10	fall	fall	NN
cord-023168-cd7adns8	745	11	in	in	IN
cord-023168-cd7adns8	745	12	the	the	DT
cord-023168-cd7adns8	745	13	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	745	14	level	level	NN
cord-023168-cd7adns8	745	15	between	between	IN
cord-023168-cd7adns8	745	16	transfusions	transfusion	NNS
cord-023168-cd7adns8	745	17	and	and	CC
cord-023168-cd7adns8	745	18	this	this	DT
cord-023168-cd7adns8	745	19	can	can	MD
cord-023168-cd7adns8	745	20	be	be	VB
cord-023168-cd7adns8	745	21	used	use	VBN
cord-023168-cd7adns8	745	22	to	to	TO
cord-023168-cd7adns8	745	23	indicate	indicate	VB
cord-023168-cd7adns8	745	24	the	the	DT
cord-023168-cd7adns8	745	25	frequency	frequency	NN
cord-023168-cd7adns8	745	26	of	of	IN
cord-023168-cd7adns8	745	27	transfusions	transfusion	NNS
cord-023168-cd7adns8	745	28	.	.	.
cord-023168-cd7adns8	746	1	Exchange	exchange	NN
cord-023168-cd7adns8	746	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	746	3	have	have	VBP
cord-023168-cd7adns8	746	4	been	be	VBN
cord-023168-cd7adns8	746	5	tried	try	VBN
cord-023168-cd7adns8	746	6	as	as	IN
cord-023168-cd7adns8	746	7	a	a	DT
cord-023168-cd7adns8	746	8	way	way	NN
cord-023168-cd7adns8	746	9	of	of	IN
cord-023168-cd7adns8	746	10	reducing	reduce	VBG
cord-023168-cd7adns8	746	11	iron	iron	NN
cord-023168-cd7adns8	746	12	loading	loading	NN
cord-023168-cd7adns8	746	13	and	and	CC
cord-023168-cd7adns8	746	14	are	be	VBP
cord-023168-cd7adns8	746	15	associated	associate	VBN
cord-023168-cd7adns8	746	16	with	with	IN
cord-023168-cd7adns8	746	17	a	a	DT
cord-023168-cd7adns8	746	18	reduction	reduction	NN
cord-023168-cd7adns8	746	19	in	in	IN
cord-023168-cd7adns8	746	20	blood	blood	NN
cord-023168-cd7adns8	746	21	requirements	requirement	NNS
cord-023168-cd7adns8	746	22	by	by	IN
cord-023168-cd7adns8	746	23	about	about	RB
cord-023168-cd7adns8	746	24	one	one	CD
cord-023168-cd7adns8	746	25	-	-	HYPH
cord-023168-cd7adns8	746	26	third	third	NN
cord-023168-cd7adns8	746	27	.	.	.
cord-023168-cd7adns8	747	1	(	(	-LRB-
cord-023168-cd7adns8	747	2	Table	table	NN
cord-023168-cd7adns8	747	3	65	65	CD
cord-023168-cd7adns8	747	4	.	.	.
cord-023168-cd7adns8	747	5	 	 	_SP
cord-023168-cd7adns8	748	1	Since	since	IN
cord-023168-cd7adns8	748	2	each	each	DT
cord-023168-cd7adns8	748	3	unit	unit	NN
cord-023168-cd7adns8	748	4	of	of	IN
cord-023168-cd7adns8	748	5	red	red	JJ
cord-023168-cd7adns8	748	6	cells	cell	NNS
cord-023168-cd7adns8	748	7	can	can	MD
cord-023168-cd7adns8	748	8	contain	contain	VB
cord-023168-cd7adns8	748	9	up	up	IN
cord-023168-cd7adns8	748	10	to	to	TO
cord-023168-cd7adns8	748	11	200	200	CD
cord-023168-cd7adns8	748	12	mg	mg	NN
cord-023168-cd7adns8	748	13	of	of	IN
cord-023168-cd7adns8	748	14	iron	iron	NN
cord-023168-cd7adns8	748	15	,	,	,
cord-023168-cd7adns8	748	16	cumulative	cumulative	JJ
cord-023168-cd7adns8	748	17	iron	iron	NN
cord-023168-cd7adns8	748	18	burden	burden	NN
cord-023168-cd7adns8	748	19	is	be	VBZ
cord-023168-cd7adns8	748	20	an	an	DT
cord-023168-cd7adns8	748	21	inevitable	inevitable	JJ
cord-023168-cd7adns8	748	22	consequence	consequence	NN
cord-023168-cd7adns8	748	23	of	of	IN
cord-023168-cd7adns8	748	24	a	a	DT
cord-023168-cd7adns8	748	25	longterm	longterm	JJ
cord-023168-cd7adns8	748	26	transfusion	transfusion	NN
cord-023168-cd7adns8	748	27	programme	programme	NN
cord-023168-cd7adns8	748	28	.	.	.
cord-023168-cd7adns8	749	1	In	in	IN
cord-023168-cd7adns8	749	2	addition	addition	NN
cord-023168-cd7adns8	749	3	there	there	EX
cord-023168-cd7adns8	749	4	is	be	VBZ
cord-023168-cd7adns8	749	5	increased	increase	VBN
cord-023168-cd7adns8	749	6	iron	iron	NN
cord-023168-cd7adns8	749	7	absorption	absorption	NN
cord-023168-cd7adns8	749	8	from	from	IN
cord-023168-cd7adns8	749	9	the	the	DT
cord-023168-cd7adns8	749	10	gut	gut	NN
cord-023168-cd7adns8	749	11	(	(	-LRB-
cord-023168-cd7adns8	749	12	0.3	0.3	CD
cord-023168-cd7adns8	749	13	-	-	SYM
cord-023168-cd7adns8	749	14	0.6	0.6	CD
cord-023168-cd7adns8	749	15	mg	mg	NNP
cord-023168-cd7adns8	749	16	/	/	SYM
cord-023168-cd7adns8	749	17	kg	kg	NN
cord-023168-cd7adns8	749	18	per	per	IN
cord-023168-cd7adns8	749	19	day	day	NN
cord-023168-cd7adns8	749	20	)	)	-RRB-
cord-023168-cd7adns8	749	21	as	as	IN
cord-023168-cd7adns8	749	22	a	a	DT
cord-023168-cd7adns8	749	23	response	response	NN
cord-023168-cd7adns8	749	24	to	to	IN
cord-023168-cd7adns8	749	25	severe	severe	JJ
cord-023168-cd7adns8	749	26	anaemia	anaemia	NN
cord-023168-cd7adns8	749	27	and	and	CC
cord-023168-cd7adns8	749	28	down	down	JJ
cord-023168-cd7adns8	749	29	-	-	HYPH
cord-023168-cd7adns8	749	30	regulation	regulation	NN
cord-023168-cd7adns8	749	31	of	of	IN
cord-023168-cd7adns8	749	32	hepcidin	hepcidin	NNP
cord-023168-cd7adns8	749	33	.	.	.
cord-023168-cd7adns8	749	34	 	 	_SP
cord-023168-cd7adns8	750	1	transfusion	transfusion	NN
cord-023168-cd7adns8	750	2	therapy	therapy	NN
cord-023168-cd7adns8	750	3	can	can	MD
cord-023168-cd7adns8	750	4	avert	avert	VB
cord-023168-cd7adns8	750	5	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	750	6	,	,	,
cord-023168-cd7adns8	750	7	hypersplenism	hypersplenism	NN
cord-023168-cd7adns8	750	8	still	still	RB
cord-023168-cd7adns8	750	9	can	can	MD
cord-023168-cd7adns8	750	10	develop	develop	VB
cord-023168-cd7adns8	750	11	,	,	,
cord-023168-cd7adns8	750	12	usually	usually	RB
cord-023168-cd7adns8	750	13	in	in	IN
cord-023168-cd7adns8	750	14	children	child	NNS
cord-023168-cd7adns8	750	15	between	between	IN
cord-023168-cd7adns8	750	16	5	5	CD
cord-023168-cd7adns8	750	17	and	and	CC
cord-023168-cd7adns8	750	18	10	10	CD
cord-023168-cd7adns8	750	19	years	year	NNS
cord-023168-cd7adns8	750	20	of	of	IN
cord-023168-cd7adns8	750	21	age	age	NN
cord-023168-cd7adns8	750	22	.	.	.
cord-023168-cd7adns8	751	1	In	in	IN
cord-023168-cd7adns8	751	2	these	these	DT
cord-023168-cd7adns8	751	3	individuals	individual	NNS
cord-023168-cd7adns8	751	4	,	,	,
cord-023168-cd7adns8	751	5	splenectomy	splenectomy	NN
cord-023168-cd7adns8	751	6	can	can	MD
cord-023168-cd7adns8	751	7	limit	limit	VB
cord-023168-cd7adns8	751	8	the	the	DT
cord-023168-cd7adns8	751	9	complications	complication	NNS
cord-023168-cd7adns8	751	10	from	from	IN
cord-023168-cd7adns8	751	11	extramedullary	extramedullary	NNP
cord-023168-cd7adns8	751	12	hematopoiesis	hematopoiesis	NNP
cord-023168-cd7adns8	751	13	.	.	.
cord-023168-cd7adns8	752	1	Splenectomy	Splenectomy	NNP
cord-023168-cd7adns8	752	2	should	should	MD
cord-023168-cd7adns8	752	3	be	be	VB
cord-023168-cd7adns8	752	4	considered	consider	VBN
cord-023168-cd7adns8	752	5	when	when	WRB
cord-023168-cd7adns8	752	6	the	the	DT
cord-023168-cd7adns8	752	7	annual	annual	JJ
cord-023168-cd7adns8	752	8	transfusion	transfusion	NN
cord-023168-cd7adns8	752	9	requirement	requirement	NN
cord-023168-cd7adns8	752	10	reaches	reach	VBZ
cord-023168-cd7adns8	752	11	200	200	CD
cord-023168-cd7adns8	752	12	-	-	SYM
cord-023168-cd7adns8	752	13	250	250	CD
cord-023168-cd7adns8	752	14	mL	ml	NN
cord-023168-cd7adns8	752	15	red	red	JJ
cord-023168-cd7adns8	752	16	blood	blood	NN
cord-023168-cd7adns8	752	17	cells	cell	NNS
cord-023168-cd7adns8	752	18	/	/	SYM
cord-023168-cd7adns8	752	19	kg	kg	NN
cord-023168-cd7adns8	752	20	per	per	IN
cord-023168-cd7adns8	752	21	year	year	NN
cord-023168-cd7adns8	752	22	and	and	CC
cord-023168-cd7adns8	752	23	usually	usually	RB
cord-023168-cd7adns8	752	24	results	result	VBZ
cord-023168-cd7adns8	752	25	in	in	IN
cord-023168-cd7adns8	752	26	a	a	DT
cord-023168-cd7adns8	752	27	halving	halving	NN
cord-023168-cd7adns8	752	28	of	of	IN
cord-023168-cd7adns8	752	29	the	the	DT
cord-023168-cd7adns8	752	30	transfusion	transfusion	NN
cord-023168-cd7adns8	752	31	requirements	requirement	NNS
cord-023168-cd7adns8	752	32	.	.	.
cord-023168-cd7adns8	753	1	Splenectomy	Splenectomy	NNP
cord-023168-cd7adns8	753	2	complications	complication	NNS
cord-023168-cd7adns8	753	3	include	include	VBP
cord-023168-cd7adns8	753	4	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	753	5	infections	infection	NNS
cord-023168-cd7adns8	753	6	with	with	IN
cord-023168-cd7adns8	753	7	encapsulated	encapsulate	VBN
cord-023168-cd7adns8	753	8	organisms	organism	NNS
cord-023168-cd7adns8	753	9	.	.	.
cord-023168-cd7adns8	754	1	Patients	patient	NNS
cord-023168-cd7adns8	754	2	should	should	MD
cord-023168-cd7adns8	754	3	therefore	therefore	RB
cord-023168-cd7adns8	754	4	receive	receive	VB
cord-023168-cd7adns8	754	5	appropriate	appropriate	JJ
cord-023168-cd7adns8	754	6	vaccinations	vaccination	NNS
cord-023168-cd7adns8	754	7	preoperatively	preoperatively	RB
cord-023168-cd7adns8	754	8	and	and	CC
cord-023168-cd7adns8	754	9	should	should	MD
cord-023168-cd7adns8	754	10	be	be	VB
cord-023168-cd7adns8	754	11	advised	advise	VBN
cord-023168-cd7adns8	754	12	to	to	TO
cord-023168-cd7adns8	754	13	seek	seek	VB
cord-023168-cd7adns8	754	14	medical	medical	JJ
cord-023168-cd7adns8	754	15	advice	advice	NN
cord-023168-cd7adns8	754	16	at	at	IN
cord-023168-cd7adns8	754	17	the	the	DT
cord-023168-cd7adns8	754	18	first	first	JJ
cord-023168-cd7adns8	754	19	sign	sign	NN
cord-023168-cd7adns8	754	20	of	of	IN
cord-023168-cd7adns8	754	21	infection	infection	NN
cord-023168-cd7adns8	754	22	.	.	.
cord-023168-cd7adns8	755	1	It	-PRON-	PRP
cord-023168-cd7adns8	755	2	is	be	VBZ
cord-023168-cd7adns8	755	3	advisable	advisable	JJ
cord-023168-cd7adns8	755	4	to	to	TO
cord-023168-cd7adns8	755	5	delay	delay	VB
cord-023168-cd7adns8	755	6	splenectomy	splenectomy	NN
cord-023168-cd7adns8	755	7	until	until	IN
cord-023168-cd7adns8	755	8	patients	patient	NNS
cord-023168-cd7adns8	755	9	are	be	VBP
cord-023168-cd7adns8	755	10	at	at	IN
cord-023168-cd7adns8	755	11	least	least	JJS
cord-023168-cd7adns8	755	12	5	5	CD
cord-023168-cd7adns8	755	13	years	year	NNS
cord-023168-cd7adns8	755	14	old	old	JJ
cord-023168-cd7adns8	755	15	because	because	IN
cord-023168-cd7adns8	755	16	of	of	IN
cord-023168-cd7adns8	755	17	the	the	DT
cord-023168-cd7adns8	755	18	increased	increase	VBN
cord-023168-cd7adns8	755	19	risk	risk	NN
cord-023168-cd7adns8	755	20	of	of	IN
cord-023168-cd7adns8	755	21	overwhelming	overwhelming	JJ
cord-023168-cd7adns8	755	22	sepsis	sepsis	NN
cord-023168-cd7adns8	755	23	below	below	IN
cord-023168-cd7adns8	755	24	this	this	DT
cord-023168-cd7adns8	755	25	age	age	NN
cord-023168-cd7adns8	755	26	.	.	.
cord-023168-cd7adns8	756	1	Thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	756	2	patients	patient	NNS
cord-023168-cd7adns8	756	3	can	can	MD
cord-023168-cd7adns8	756	4	develop	develop	VB
cord-023168-cd7adns8	756	5	thromboembolic	thromboembolic	JJ
cord-023168-cd7adns8	756	6	complications	complication	NNS
cord-023168-cd7adns8	756	7	and	and	CC
cord-023168-cd7adns8	756	8	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	756	9	hypertension	hypertension	NN
cord-023168-cd7adns8	756	10	after	after	IN
cord-023168-cd7adns8	756	11	splenectomy	splenectomy	NN
cord-023168-cd7adns8	756	12	so	so	RB
cord-023168-cd7adns8	756	13	partial	partial	JJ
cord-023168-cd7adns8	756	14	splenectomy	splenectomy	NN
cord-023168-cd7adns8	756	15	and	and	CC
cord-023168-cd7adns8	756	16	splenic	splenic	JJ
cord-023168-cd7adns8	756	17	embolization	embolization	NN
cord-023168-cd7adns8	756	18	have	have	VBP
cord-023168-cd7adns8	756	19	been	be	VBN
cord-023168-cd7adns8	756	20	attempted	attempt	VBN
cord-023168-cd7adns8	756	21	to	to	TO
cord-023168-cd7adns8	756	22	minimize	minimize	VB
cord-023168-cd7adns8	756	23	these	these	DT
cord-023168-cd7adns8	756	24	complications	complication	NNS
cord-023168-cd7adns8	756	25	but	but	CC
cord-023168-cd7adns8	756	26	have	have	VBP
cord-023168-cd7adns8	756	27	not	not	RB
cord-023168-cd7adns8	756	28	been	be	VBN
cord-023168-cd7adns8	756	29	studied	study	VBN
cord-023168-cd7adns8	756	30	in	in	IN
cord-023168-cd7adns8	756	31	large	large	JJ
cord-023168-cd7adns8	756	32	trials	trial	NNS
cord-023168-cd7adns8	756	33	.	.	.
cord-023168-cd7adns8	757	1	Iron	iron	NN
cord-023168-cd7adns8	757	2	overload	overload	NN
cord-023168-cd7adns8	757	3	can	can	MD
cord-023168-cd7adns8	757	4	occur	occur	VB
cord-023168-cd7adns8	757	5	in	in	IN
cord-023168-cd7adns8	757	6	any	any	DT
cord-023168-cd7adns8	757	7	organ	organ	NN
cord-023168-cd7adns8	757	8	in	in	IN
cord-023168-cd7adns8	757	9	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	757	10	patients	patient	NNS
cord-023168-cd7adns8	757	11	but	but	CC
cord-023168-cd7adns8	757	12	particularly	particularly	RB
cord-023168-cd7adns8	757	13	affects	affect	VBZ
cord-023168-cd7adns8	757	14	the	the	DT
cord-023168-cd7adns8	757	15	heart	heart	NN
cord-023168-cd7adns8	757	16	,	,	,
cord-023168-cd7adns8	757	17	liver	liver	NN
cord-023168-cd7adns8	757	18	,	,	,
cord-023168-cd7adns8	757	19	the	the	DT
cord-023168-cd7adns8	757	20	endocrine	endocrine	NN
cord-023168-cd7adns8	757	21	system	system	NN
cord-023168-cd7adns8	757	22	,	,	,
cord-023168-cd7adns8	757	23	the	the	DT
cord-023168-cd7adns8	757	24	bone	bone	NN
cord-023168-cd7adns8	757	25	and	and	CC
cord-023168-cd7adns8	757	26	occasionally	occasionally	RB
cord-023168-cd7adns8	757	27	the	the	DT
cord-023168-cd7adns8	757	28	pancreas	pancrea	NNS
cord-023168-cd7adns8	757	29	and	and	CC
cord-023168-cd7adns8	757	30	lungs	lung	NNS
cord-023168-cd7adns8	757	31	.	.	.
cord-023168-cd7adns8	758	1	Iron	iron	NN
cord-023168-cd7adns8	758	2	overload	overload	NN
cord-023168-cd7adns8	758	3	needs	need	VBZ
cord-023168-cd7adns8	758	4	to	to	TO
cord-023168-cd7adns8	758	5	be	be	VB
cord-023168-cd7adns8	758	6	detected	detect	VBN
cord-023168-cd7adns8	758	7	early	early	RB
cord-023168-cd7adns8	758	8	and	and	CC
cord-023168-cd7adns8	758	9	treated	treat	VBN
cord-023168-cd7adns8	758	10	to	to	TO
cord-023168-cd7adns8	758	11	prevent	prevent	VB
cord-023168-cd7adns8	758	12	long	long	JJ
cord-023168-cd7adns8	758	13	-	-	HYPH
cord-023168-cd7adns8	758	14	term	term	NN
cord-023168-cd7adns8	758	15	damage	damage	NN
cord-023168-cd7adns8	758	16	.	.	.
cord-023168-cd7adns8	759	1	Annual	annual	JJ
cord-023168-cd7adns8	759	2	assessment	assessment	NN
cord-023168-cd7adns8	759	3	of	of	IN
cord-023168-cd7adns8	759	4	the	the	DT
cord-023168-cd7adns8	759	5	iron	iron	NN
cord-023168-cd7adns8	759	6	loading	loading	NN
cord-023168-cd7adns8	759	7	of	of	IN
cord-023168-cd7adns8	759	8	the	the	DT
cord-023168-cd7adns8	759	9	liver	liver	NN
cord-023168-cd7adns8	759	10	and	and	CC
cord-023168-cd7adns8	759	11	heart	heart	NN
cord-023168-cd7adns8	759	12	can	can	MD
cord-023168-cd7adns8	759	13	be	be	VB
cord-023168-cd7adns8	759	14	achieved	achieve	VBN
cord-023168-cd7adns8	759	15	using	use	VBG
cord-023168-cd7adns8	759	16	non	non	JJ
cord-023168-cd7adns8	759	17	-	-	JJ
cord-023168-cd7adns8	759	18	invasive	invasive	JJ
cord-023168-cd7adns8	759	19	methods	method	NNS
cord-023168-cd7adns8	759	20	such	such	JJ
cord-023168-cd7adns8	759	21	as	as	IN
cord-023168-cd7adns8	759	22	magnetic	magnetic	JJ
cord-023168-cd7adns8	759	23	resonance	resonance	NN
cord-023168-cd7adns8	759	24	scanning	scanning	NN
cord-023168-cd7adns8	759	25	to	to	TO
cord-023168-cd7adns8	759	26	detect	detect	VB
cord-023168-cd7adns8	759	27	early	early	JJ
cord-023168-cd7adns8	759	28	changes	change	NNS
cord-023168-cd7adns8	759	29	.	.	.
cord-023168-cd7adns8	760	1	Children	child	NNS
cord-023168-cd7adns8	760	2	should	should	MD
cord-023168-cd7adns8	760	3	have	have	VB
cord-023168-cd7adns8	760	4	regular	regular	JJ
cord-023168-cd7adns8	760	5	growth	growth	NN
cord-023168-cd7adns8	760	6	and	and	CC
cord-023168-cd7adns8	760	7	endocrine	endocrine	JJ
cord-023168-cd7adns8	760	8	assessments	assessment	NNS
cord-023168-cd7adns8	760	9	and	and	CC
cord-023168-cd7adns8	760	10	appropriate	appropriate	JJ
cord-023168-cd7adns8	760	11	investigations	investigation	NNS
cord-023168-cd7adns8	760	12	should	should	MD
cord-023168-cd7adns8	760	13	be	be	VB
cord-023168-cd7adns8	760	14	carried	carry	VBN
cord-023168-cd7adns8	760	15	out	out	RP
cord-023168-cd7adns8	760	16	if	if	IN
cord-023168-cd7adns8	760	17	there	there	EX
cord-023168-cd7adns8	760	18	are	be	VBP
cord-023168-cd7adns8	760	19	any	any	DT
cord-023168-cd7adns8	760	20	signs	sign	NNS
cord-023168-cd7adns8	760	21	of	of	IN
cord-023168-cd7adns8	760	22	developmental	developmental	JJ
cord-023168-cd7adns8	760	23	delay	delay	NN
cord-023168-cd7adns8	760	24	or	or	CC
cord-023168-cd7adns8	760	25	hormonal	hormonal	JJ
cord-023168-cd7adns8	760	26	deficiencies	deficiency	NNS
cord-023168-cd7adns8	760	27	.	.	.
cord-023168-cd7adns8	761	1	Osteoporosis	osteoporosis	NN
cord-023168-cd7adns8	761	2	is	be	VBZ
cord-023168-cd7adns8	761	3	increasingly	increasingly	RB
cord-023168-cd7adns8	761	4	being	be	VBG
cord-023168-cd7adns8	761	5	recognized	recognize	VBN
cord-023168-cd7adns8	761	6	and	and	CC
cord-023168-cd7adns8	761	7	should	should	MD
cord-023168-cd7adns8	761	8	be	be	VB
cord-023168-cd7adns8	761	9	prevented	prevent	VBN
cord-023168-cd7adns8	761	10	by	by	IN
cord-023168-cd7adns8	761	11	ensuring	ensure	VBG
cord-023168-cd7adns8	761	12	adequate	adequate	JJ
cord-023168-cd7adns8	761	13	dietary	dietary	JJ
cord-023168-cd7adns8	761	14	calcium	calcium	NN
cord-023168-cd7adns8	761	15	intake	intake	NN
cord-023168-cd7adns8	761	16	and	and	CC
cord-023168-cd7adns8	761	17	sun	sun	NN
cord-023168-cd7adns8	761	18	exposure	exposure	NN
cord-023168-cd7adns8	761	19	.	.	.
cord-023168-cd7adns8	762	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	762	2	supplementation	supplementation	NN
cord-023168-cd7adns8	762	3	with	with	IN
cord-023168-cd7adns8	762	4	folic	folic	JJ
cord-023168-cd7adns8	762	5	acid	acid	NN
cord-023168-cd7adns8	762	6	,	,	,
cord-023168-cd7adns8	762	7	zinc	zinc	NN
cord-023168-cd7adns8	762	8	,	,	,
cord-023168-cd7adns8	762	9	vitamin	vitamin	NN
cord-023168-cd7adns8	762	10	E	e	NN
cord-023168-cd7adns8	762	11	and	and	CC
cord-023168-cd7adns8	762	12	vitamin	vitamin	NN
cord-023168-cd7adns8	762	13	C	c	NN
cord-023168-cd7adns8	762	14	may	may	MD
cord-023168-cd7adns8	762	15	be	be	VB
cord-023168-cd7adns8	762	16	useful	useful	JJ
cord-023168-cd7adns8	762	17	although	although	IN
cord-023168-cd7adns8	762	18	the	the	DT
cord-023168-cd7adns8	762	19	combination	combination	NN
cord-023168-cd7adns8	762	20	of	of	IN
cord-023168-cd7adns8	762	21	vitamin	vitamin	NN
cord-023168-cd7adns8	762	22	C	c	NN
cord-023168-cd7adns8	762	23	and	and	CC
cord-023168-cd7adns8	762	24	desferrioxamine	desferrioxamine	NN
cord-023168-cd7adns8	762	25	carries	carry	VBZ
cord-023168-cd7adns8	762	26	a	a	DT
cord-023168-cd7adns8	762	27	risk	risk	NN
cord-023168-cd7adns8	762	28	of	of	IN
cord-023168-cd7adns8	762	29	cardiac	cardiac	JJ
cord-023168-cd7adns8	762	30	toxicity	toxicity	NN
cord-023168-cd7adns8	762	31	.	.	.
cord-023168-cd7adns8	763	1	Allogeneic	allogeneic	IN
cord-023168-cd7adns8	763	2	stem	stem	NN
cord-023168-cd7adns8	763	3	cell	cell	NN
cord-023168-cd7adns8	763	4	transplant	transplant	NN
cord-023168-cd7adns8	763	5	169	169	CD
cord-023168-cd7adns8	763	6	,	,	,
cord-023168-cd7adns8	763	7	170	170	CD
cord-023168-cd7adns8	763	8	is	be	VBZ
cord-023168-cd7adns8	763	9	currently	currently	RB
cord-023168-cd7adns8	763	10	the	the	DT
cord-023168-cd7adns8	763	11	only	only	JJ
cord-023168-cd7adns8	763	12	means	mean	NNS
cord-023168-cd7adns8	763	13	of	of	IN
cord-023168-cd7adns8	763	14	curing	cure	VBG
cord-023168-cd7adns8	763	15	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	763	16	.	.	.
cord-023168-cd7adns8	764	1	The	the	DT
cord-023168-cd7adns8	764	2	outcome	outcome	NN
cord-023168-cd7adns8	764	3	in	in	IN
cord-023168-cd7adns8	764	4	carefully	carefully	RB
cord-023168-cd7adns8	764	5	selected	select	VBN
cord-023168-cd7adns8	764	6	patients	patient	NNS
cord-023168-cd7adns8	764	7	,	,	,
cord-023168-cd7adns8	764	8	measured	measure	VBN
cord-023168-cd7adns8	764	9	by	by	IN
cord-023168-cd7adns8	764	10	overall	overall	JJ
cord-023168-cd7adns8	764	11	event	event	NN
cord-023168-cd7adns8	764	12	-	-	HYPH
cord-023168-cd7adns8	764	13	free	free	JJ
cord-023168-cd7adns8	764	14	survival	survival	NN
cord-023168-cd7adns8	764	15	,	,	,
cord-023168-cd7adns8	764	16	is	be	VBZ
cord-023168-cd7adns8	764	17	around	around	RB
cord-023168-cd7adns8	764	18	90	90	CD
cord-023168-cd7adns8	764	19	%	%	NN
cord-023168-cd7adns8	764	20	with	with	IN
cord-023168-cd7adns8	764	21	a	a	DT
cord-023168-cd7adns8	764	22	transplant	transplant	NN
cord-023168-cd7adns8	764	23	-	-	HYPH
cord-023168-cd7adns8	764	24	related	relate	VBN
cord-023168-cd7adns8	764	25	mortality	mortality	NN
cord-023168-cd7adns8	764	26	of	of	IN
cord-023168-cd7adns8	764	27	3	3	CD
cord-023168-cd7adns8	764	28	%	%	NN
cord-023168-cd7adns8	764	29	.	.	.
cord-023168-cd7adns8	765	1	Hepatomegaly	Hepatomegaly	NNP
cord-023168-cd7adns8	765	2	,	,	,
cord-023168-cd7adns8	765	3	liver	liver	NN
cord-023168-cd7adns8	765	4	fibrosis	fibrosis	NN
cord-023168-cd7adns8	765	5	,	,	,
cord-023168-cd7adns8	765	6	and	and	CC
cord-023168-cd7adns8	765	7	inadequate	inadequate	JJ
cord-023168-cd7adns8	765	8	iron	iron	NN
cord-023168-cd7adns8	765	9	chelation	chelation	NN
cord-023168-cd7adns8	765	10	therapy	therapy	NN
cord-023168-cd7adns8	765	11	predict	predict	VBP
cord-023168-cd7adns8	765	12	a	a	DT
cord-023168-cd7adns8	765	13	poor	poor	JJ
cord-023168-cd7adns8	765	14	outcome	outcome	NN
cord-023168-cd7adns8	765	15	.	.	.
cord-023168-cd7adns8	766	1	The	the	DT
cord-023168-cd7adns8	766	2	best	good	JJS
cord-023168-cd7adns8	766	3	results	result	NNS
cord-023168-cd7adns8	766	4	from	from	IN
cord-023168-cd7adns8	766	5	transplant	transplant	NN
cord-023168-cd7adns8	766	6	have	have	VBP
cord-023168-cd7adns8	766	7	been	be	VBN
cord-023168-cd7adns8	766	8	obtained	obtain	VBN
cord-023168-cd7adns8	766	9	with	with	IN
cord-023168-cd7adns8	766	10	HLA	HLA	NNP
cord-023168-cd7adns8	766	11	-	-	HYPH
cord-023168-cd7adns8	766	12	matched	match	VBN
cord-023168-cd7adns8	766	13	siblings	sibling	NNS
cord-023168-cd7adns8	766	14	.	.	.
cord-023168-cd7adns8	767	1	Umbilical	umbilical	JJ
cord-023168-cd7adns8	767	2	cord	cord	NN
cord-023168-cd7adns8	767	3	blood	blood	NN
cord-023168-cd7adns8	767	4	is	be	VBZ
cord-023168-cd7adns8	767	5	a	a	DT
cord-023168-cd7adns8	767	6	useful	useful	JJ
cord-023168-cd7adns8	767	7	source	source	NN
cord-023168-cd7adns8	767	8	of	of	IN
cord-023168-cd7adns8	767	9	stem	stem	NN
cord-023168-cd7adns8	767	10	cells	cell	NNS
cord-023168-cd7adns8	767	11	for	for	IN
cord-023168-cd7adns8	767	12	young	young	JJ
cord-023168-cd7adns8	767	13	children	child	NNS
cord-023168-cd7adns8	767	14	.	.	.
cord-023168-cd7adns8	768	1	Other	other	JJ
cord-023168-cd7adns8	768	2	potential	potential	JJ
cord-023168-cd7adns8	768	3	treatment	treatment	NN
cord-023168-cd7adns8	768	4	options	option	NNS
cord-023168-cd7adns8	768	5	for	for	IN
cord-023168-cd7adns8	768	6	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	768	7	are	be	VBP
cord-023168-cd7adns8	768	8	outlined	outline	VBN
cord-023168-cd7adns8	768	9	in	in	IN
cord-023168-cd7adns8	768	10	Box	Box	NNP
cord-023168-cd7adns8	768	11	65.16	65.16	CD
cord-023168-cd7adns8	768	12	.	.	.
cord-023168-cd7adns8	769	1	[	[	-LRB-
cord-023168-cd7adns8	769	2	171	171	CD
cord-023168-cd7adns8	769	3	]	]	-RRB-
cord-023168-cd7adns8	769	4	[	[	-LRB-
cord-023168-cd7adns8	769	5	172	172	CD
cord-023168-cd7adns8	769	6	]	]	-RRB-
cord-023168-cd7adns8	770	1	[	[	-LRB-
cord-023168-cd7adns8	770	2	173	173	CD
cord-023168-cd7adns8	770	3	]	]	-RRB-
cord-023168-cd7adns8	771	1	[	[	-LRB-
cord-023168-cd7adns8	771	2	174	174	CD
cord-023168-cd7adns8	771	3	]	]	-RRB-
cord-023168-cd7adns8	771	4	 	 	_SP
cord-023168-cd7adns8	771	5	Prevention	Prevention	NNP
cord-023168-cd7adns8	771	6	of	of	IN
cord-023168-cd7adns8	771	7	severe	severe	JJ
cord-023168-cd7adns8	771	8	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	771	9	births	birth	NNS
cord-023168-cd7adns8	771	10	by	by	IN
cord-023168-cd7adns8	771	11	prenatal	prenatal	JJ
cord-023168-cd7adns8	771	12	diagnosis	diagnosis	NN
cord-023168-cd7adns8	771	13	and	and	CC
cord-023168-cd7adns8	771	14	termination	termination	NN
cord-023168-cd7adns8	771	15	of	of	IN
cord-023168-cd7adns8	771	16	pregnancies	pregnancy	NNS
cord-023168-cd7adns8	771	17	has	have	VBZ
cord-023168-cd7adns8	771	18	been	be	VBN
cord-023168-cd7adns8	771	19	successful	successful	JJ
cord-023168-cd7adns8	771	20	in	in	IN
cord-023168-cd7adns8	771	21	countries	country	NNS
cord-023168-cd7adns8	771	22	with	with	IN
cord-023168-cd7adns8	771	23	a	a	DT
cord-023168-cd7adns8	771	24	high	high	JJ
cord-023168-cd7adns8	771	25	prevalence	prevalence	NN
cord-023168-cd7adns8	771	26	of	of	IN
cord-023168-cd7adns8	771	27	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	771	28	.	.	.
cord-023168-cd7adns8	772	1	175	175	CD
cord-023168-cd7adns8	772	2	Early	early	JJ
cord-023168-cd7adns8	772	3	identification	identification	NN
cord-023168-cd7adns8	772	4	of	of	IN
cord-023168-cd7adns8	772	5	couples	couple	NNS
cord-023168-cd7adns8	772	6	at	at	IN
cord-023168-cd7adns8	772	7	risk	risk	NN
cord-023168-cd7adns8	772	8	and	and	CC
cord-023168-cd7adns8	772	9	culturally	culturally	RB
cord-023168-cd7adns8	772	10	sensitive	sensitive	JJ
cord-023168-cd7adns8	772	11	genetic	genetic	JJ
cord-023168-cd7adns8	772	12	counselling	counselling	NN
cord-023168-cd7adns8	772	13	facilitate	facilitate	VBP
cord-023168-cd7adns8	772	14	decision	decision	NN
cord-023168-cd7adns8	772	15	-	-	HYPH
cord-023168-cd7adns8	772	16	making	making	NN
cord-023168-cd7adns8	772	17	for	for	IN
cord-023168-cd7adns8	772	18	termination	termination	NN
cord-023168-cd7adns8	772	19	or	or	CC
cord-023168-cd7adns8	772	20	continuation	continuation	NN
cord-023168-cd7adns8	772	21	of	of	IN
cord-023168-cd7adns8	772	22	pregnancy	pregnancy	NN
cord-023168-cd7adns8	772	23	.	.	.
cord-023168-cd7adns8	773	1	The	the	DT
cord-023168-cd7adns8	773	2	mean	mean	JJ
cord-023168-cd7adns8	773	3	corpuscular	corpuscular	JJ
cord-023168-cd7adns8	773	4	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	773	5	(	(	-LRB-
cord-023168-cd7adns8	773	6	MCH	MCH	NNP
cord-023168-cd7adns8	773	7	)	)	-RRB-
cord-023168-cd7adns8	773	8	is	be	VBZ
cord-023168-cd7adns8	773	9	used	use	VBN
cord-023168-cd7adns8	773	10	to	to	TO
cord-023168-cd7adns8	773	11	screen	screen	VB
cord-023168-cd7adns8	773	12	for	for	IN
cord-023168-cd7adns8	773	13	the	the	DT
cord-023168-cd7adns8	773	14	presence	presence	NN
cord-023168-cd7adns8	773	15	of	of	IN
cord-023168-cd7adns8	773	16	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	773	17	using	use	VBG
cord-023168-cd7adns8	773	18	a	a	DT
cord-023168-cd7adns8	773	19	cut	cut	NN
cord-023168-cd7adns8	773	20	-	-	HYPH
cord-023168-cd7adns8	773	21	off	off	NN
cord-023168-cd7adns8	773	22	of	of	IN
cord-023168-cd7adns8	773	23	less	less	JJR
cord-023168-cd7adns8	773	24	than	than	IN
cord-023168-cd7adns8	773	25	27	27	CD
cord-023168-cd7adns8	773	26	pg	pg	NN
cord-023168-cd7adns8	773	27	.	.	.
cord-023168-cd7adns8	774	1	Rarely	rarely	RB
cord-023168-cd7adns8	774	2	,	,	,
cord-023168-cd7adns8	774	3	silent	silent	JJ
cord-023168-cd7adns8	774	4	β	β	NN
cord-023168-cd7adns8	774	5	-	-	HYPH
cord-023168-cd7adns8	774	6	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	774	7	mutation	mutation	NN
cord-023168-cd7adns8	774	8	may	may	MD
cord-023168-cd7adns8	774	9	present	present	VB
cord-023168-cd7adns8	774	10	with	with	IN
cord-023168-cd7adns8	774	11	an	an	DT
cord-023168-cd7adns8	774	12	MCV	MCV	NNP
cord-023168-cd7adns8	774	13	over	over	IN
cord-023168-cd7adns8	774	14	27	27	CD
cord-023168-cd7adns8	774	15	pg	pg	NN
cord-023168-cd7adns8	774	16	and	and	CC
cord-023168-cd7adns8	774	17	should	should	MD
cord-023168-cd7adns8	774	18	be	be	VB
cord-023168-cd7adns8	774	19	considered	consider	VBN
cord-023168-cd7adns8	774	20	in	in	IN
cord-023168-cd7adns8	774	21	those	those	DT
cord-023168-cd7adns8	774	22	with	with	IN
cord-023168-cd7adns8	774	23	a	a	DT
cord-023168-cd7adns8	774	24	positive	positive	JJ
cord-023168-cd7adns8	774	25	family	family	NN
cord-023168-cd7adns8	774	26	history	history	NN
cord-023168-cd7adns8	774	27	.	.	.
cord-023168-cd7adns8	775	1	At	at	IN
cord-023168-cd7adns8	775	2	-	-	HYPH
cord-023168-cd7adns8	775	3	risk	risk	NN
cord-023168-cd7adns8	775	4	couples	couple	NNS
cord-023168-cd7adns8	775	5	should	should	MD
cord-023168-cd7adns8	775	6	be	be	VB
cord-023168-cd7adns8	775	7	referred	refer	VBN
cord-023168-cd7adns8	775	8	for	for	IN
cord-023168-cd7adns8	775	9	detailed	detailed	JJ
cord-023168-cd7adns8	775	10	counselling	counselling	NN
cord-023168-cd7adns8	775	11	on	on	IN
cord-023168-cd7adns8	775	12	the	the	DT
cord-023168-cd7adns8	775	13	options	option	NNS
cord-023168-cd7adns8	775	14	for	for	IN
cord-023168-cd7adns8	775	15	prenatal	prenatal	JJ
cord-023168-cd7adns8	775	16	diagnosis	diagnosis	NN
cord-023168-cd7adns8	775	17	.	.	.
cord-023168-cd7adns8	776	1	These	these	DT
cord-023168-cd7adns8	776	2	include	include	VBP
cord-023168-cd7adns8	776	3	chorionic	chorionic	JJ
cord-023168-cd7adns8	776	4	villous	villous	NN
cord-023168-cd7adns8	776	5	sampling	sampling	NN
cord-023168-cd7adns8	776	6	or	or	CC
cord-023168-cd7adns8	776	7	amniocentesis	amniocentesis	NN
cord-023168-cd7adns8	776	8	,	,	,
cord-023168-cd7adns8	776	9	which	which	WDT
cord-023168-cd7adns8	776	10	are	be	VBP
cord-023168-cd7adns8	776	11	used	use	VBN
cord-023168-cd7adns8	776	12	to	to	TO
cord-023168-cd7adns8	776	13	obtain	obtain	VB
cord-023168-cd7adns8	776	14	fetal	fetal	JJ
cord-023168-cd7adns8	776	15	DNA	dna	NN
cord-023168-cd7adns8	776	16	samples	sample	NNS
cord-023168-cd7adns8	776	17	for	for	IN
cord-023168-cd7adns8	776	18	genetic	genetic	JJ
cord-023168-cd7adns8	776	19	analysis	analysis	NN
cord-023168-cd7adns8	776	20	.	.	.
cord-023168-cd7adns8	777	1	Polymerase	polymerase	NN
cord-023168-cd7adns8	777	2	chain	chain	NN
cord-023168-cd7adns8	777	3	reactions	reaction	NNS
cord-023168-cd7adns8	777	4	and	and	CC
cord-023168-cd7adns8	777	5	precise	precise	JJ
cord-023168-cd7adns8	777	6	hybridization	hybridization	NN
cord-023168-cd7adns8	777	7	assays	assay	NNS
cord-023168-cd7adns8	778	1	to	to	TO
cord-023168-cd7adns8	778	2	detect	detect	VB
cord-023168-cd7adns8	778	3	single	single	JJ
cord-023168-cd7adns8	778	4	point	point	NN
cord-023168-cd7adns8	778	5	mutations	mutation	NNS
cord-023168-cd7adns8	778	6	using	use	VBG
cord-023168-cd7adns8	778	7	very	very	RB
cord-023168-cd7adns8	778	8	small	small	JJ
cord-023168-cd7adns8	778	9	DNA	dna	NN
cord-023168-cd7adns8	778	10	samples	sample	NNS
cord-023168-cd7adns8	778	11	have	have	VBP
cord-023168-cd7adns8	778	12	also	also	RB
cord-023168-cd7adns8	778	13	been	be	VBN
cord-023168-cd7adns8	778	14	developed	develop	VBN
cord-023168-cd7adns8	778	15	.	.	.
cord-023168-cd7adns8	779	1	A	a	DT
cord-023168-cd7adns8	779	2	less	less	RBR
cord-023168-cd7adns8	779	3	invasive	invasive	JJ
cord-023168-cd7adns8	779	4	and	and	CC
cord-023168-cd7adns8	779	5	less	less	RBR
cord-023168-cd7adns8	779	6	risky	risky	JJ
cord-023168-cd7adns8	779	7	option	option	NN
cord-023168-cd7adns8	779	8	is	be	VBZ
cord-023168-cd7adns8	779	9	to	to	TO
cord-023168-cd7adns8	779	10	isolate	isolate	VB
cord-023168-cd7adns8	779	11	fetal	fetal	JJ
cord-023168-cd7adns8	779	12	DNA	dna	NN
cord-023168-cd7adns8	779	13	circulating	circulating	NN
cord-023168-cd7adns8	779	14	in	in	IN
cord-023168-cd7adns8	779	15	the	the	DT
cord-023168-cd7adns8	779	16	maternal	maternal	JJ
cord-023168-cd7adns8	779	17	blood	blood	NN
cord-023168-cd7adns8	779	18	for	for	IN
cord-023168-cd7adns8	779	19	genetic	genetic	JJ
cord-023168-cd7adns8	779	20	analysis	analysis	NN
cord-023168-cd7adns8	779	21	.	.	.
cord-023168-cd7adns8	780	1	Pre	pre	JJ
cord-023168-cd7adns8	780	2	-	-	JJ
cord-023168-cd7adns8	780	3	implantation	implantation	JJ
cord-023168-cd7adns8	780	4	genetic	genetic	JJ
cord-023168-cd7adns8	780	5	diagnosis	diagnosis	NN
cord-023168-cd7adns8	780	6	is	be	VBZ
cord-023168-cd7adns8	780	7	a	a	DT
cord-023168-cd7adns8	780	8	newer	new	JJR
cord-023168-cd7adns8	780	9	technique	technique	NN
cord-023168-cd7adns8	780	10	where	where	WRB
cord-023168-cd7adns8	780	11	DNA	dna	NN
cord-023168-cd7adns8	780	12	from	from	IN
cord-023168-cd7adns8	780	13	the	the	DT
cord-023168-cd7adns8	780	14	blastomere	blastomere	NN
cord-023168-cd7adns8	780	15	is	be	VBZ
cord-023168-cd7adns8	780	16	used	use	VBN
cord-023168-cd7adns8	780	17	for	for	IN
cord-023168-cd7adns8	780	18	genetic	genetic	JJ
cord-023168-cd7adns8	780	19	diagnosis	diagnosis	NN
cord-023168-cd7adns8	780	20	.	.	.
cord-023168-cd7adns8	781	1	Ultrasound	ultrasound	NN
cord-023168-cd7adns8	781	2	can	can	MD
cord-023168-cd7adns8	781	3	be	be	VB
cord-023168-cd7adns8	781	4	used	use	VBN
cord-023168-cd7adns8	781	5	from	from	IN
cord-023168-cd7adns8	781	6	the	the	DT
cord-023168-cd7adns8	781	7	2nd	2nd	JJ
cord-023168-cd7adns8	781	8	trimester	trimester	NN
cord-023168-cd7adns8	781	9	for	for	IN
cord-023168-cd7adns8	781	10	fetuses	fetus	NNS
cord-023168-cd7adns8	781	11	suspected	suspect	VBN
cord-023168-cd7adns8	781	12	of	of	IN
cord-023168-cd7adns8	781	13	having	have	VBG
cord-023168-cd7adns8	781	14	α	α	NN
cord-023168-cd7adns8	781	15	-	-	HYPH
cord-023168-cd7adns8	781	16	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	781	17	to	to	TO
cord-023168-cd7adns8	781	18	detect	detect	VB
cord-023168-cd7adns8	781	19	signs	sign	NNS
cord-023168-cd7adns8	781	20	of	of	IN
cord-023168-cd7adns8	781	21	hydrops	hydrops	NNP
cord-023168-cd7adns8	781	22	fetalis	fetalis	NNP
cord-023168-cd7adns8	781	23	and	and	CC
cord-023168-cd7adns8	781	24	enlarged	enlarged	JJ
cord-023168-cd7adns8	781	25	placenta	placenta	NN
cord-023168-cd7adns8	781	26	(	(	-LRB-
cord-023168-cd7adns8	781	27	Figure	figure	NN
cord-023168-cd7adns8	781	28	65.9	65.9	CD
cord-023168-cd7adns8	781	29	)	)	-RRB-
cord-023168-cd7adns8	781	30	.	.	.
cord-023168-cd7adns8	782	1	175	175	CD
cord-023168-cd7adns8	782	2	 	 	_SP
cord-023168-cd7adns8	783	1	•	•	NNP
cord-023168-cd7adns8	784	1	Hydroxyurea	Hydroxyurea	NNP
cord-023168-cd7adns8	784	2	-helpful	-helpful	.
cord-023168-cd7adns8	785	1	in	in	IN
cord-023168-cd7adns8	785	2	some	some	DT
cord-023168-cd7adns8	785	3	patients	patient	NNS
cord-023168-cd7adns8	785	4	with	with	IN
cord-023168-cd7adns8	785	5	β	β	NN
cord-023168-cd7adns8	785	6	-	-	HYPH
cord-023168-cd7adns8	785	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	785	8	intermedia	intermedia	NN
cord-023168-cd7adns8	785	9	,	,	,
cord-023168-cd7adns8	785	10	but	but	CC
cord-023168-cd7adns8	785	11	not	not	RB
cord-023168-cd7adns8	785	12	as	as	RB
cord-023168-cd7adns8	785	13	effective	effective	JJ
cord-023168-cd7adns8	785	14	in	in	IN
cord-023168-cd7adns8	785	15	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	785	16	major	major	JJ
cord-023168-cd7adns8	786	1	•	•	NNP
cord-023168-cd7adns8	787	1	Histone	histone	JJ
cord-023168-cd7adns8	787	2	deacetylase	deacetylase	NN
cord-023168-cd7adns8	787	3	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	787	4	-derivatives	-derivative	NNS
cord-023168-cd7adns8	787	5	of	of	IN
cord-023168-cd7adns8	787	6	butyric	butyric	NN
cord-023168-cd7adns8	787	7	acid	acid	NN
cord-023168-cd7adns8	788	1	;	;	:
cord-023168-cd7adns8	788	2	intermittent	intermittent	JJ
cord-023168-cd7adns8	788	3	pulses	pulse	NNS
cord-023168-cd7adns8	788	4	with	with	IN
cord-023168-cd7adns8	788	5	hydroxycarbamide	hydroxycarbamide	NN
cord-023168-cd7adns8	788	6	has	have	VBZ
cord-023168-cd7adns8	788	7	been	be	VBN
cord-023168-cd7adns8	788	8	tried	try	VBN
cord-023168-cd7adns8	788	9	•	•	NNP
cord-023168-cd7adns8	788	10	Kit	kit	NN
cord-023168-cd7adns8	788	11	ligand	ligand	NN
cord-023168-cd7adns8	789	1	•	•	NNP
cord-023168-cd7adns8	790	1	Decitabine	Decitabine	NNP
cord-023168-cd7adns8	791	1	•	•	NNP
cord-023168-cd7adns8	792	1	Knockdown	knockdown	NN
cord-023168-cd7adns8	792	2	of	of	IN
cord-023168-cd7adns8	792	3	BCL11A	bcl11a	NN
cord-023168-cd7adns8	793	1	(	(	-LRB-
cord-023168-cd7adns8	793	2	regulator	regulator	NN
cord-023168-cd7adns8	793	3	of	of	IN
cord-023168-cd7adns8	793	4	γ	γ	NN
cord-023168-cd7adns8	793	5	-	-	HYPH
cord-023168-cd7adns8	793	6	globin	globin	NN
cord-023168-cd7adns8	793	7	expression	expression	NN
cord-023168-cd7adns8	793	8	)	)	-RRB-
cord-023168-cd7adns8	794	1	•	•	NNP
cord-023168-cd7adns8	795	1	Erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	795	2	.	.	.
cord-023168-cd7adns8	796	1	•	•	NNP
cord-023168-cd7adns8	797	1	Vitamins	Vitamins	NNP
cord-023168-cd7adns8	797	2	C	c	NN
cord-023168-cd7adns8	797	3	and	and	CC
cord-023168-cd7adns8	797	4	E	e	NN
cord-023168-cd7adns8	797	5	•	•	NN
cord-023168-cd7adns8	798	1	Fermented	ferment	VBN
cord-023168-cd7adns8	798	2	papaya	papaya	NN
cord-023168-cd7adns8	798	3	preparations	preparation	NNS
cord-023168-cd7adns8	798	4	.	.	.
cord-023168-cd7adns8	799	1	•	•	NNP
cord-023168-cd7adns8	800	1	Successful	successful	JJ
cord-023168-cd7adns8	800	2	in	in	IN
cord-023168-cd7adns8	800	3	β	β	NN
cord-023168-cd7adns8	800	4	-	-	HYPH
cord-023168-cd7adns8	800	5	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	800	6	animal	animal	NN
cord-023168-cd7adns8	800	7	models	model	NNS
cord-023168-cd7adns8	800	8	using	use	VBG
cord-023168-cd7adns8	800	9	a	a	DT
cord-023168-cd7adns8	800	10	retroviral	retroviral	JJ
cord-023168-cd7adns8	800	11	vector	vector	NN
cord-023168-cd7adns8	800	12	transferring	transfer	VBG
cord-023168-cd7adns8	800	13	the	the	DT
cord-023168-cd7adns8	800	14	human	human	NN
cord-023168-cd7adns8	800	15	β	β	NN
cord-023168-cd7adns8	800	16	-	-	HYPH
cord-023168-cd7adns8	800	17	globin	globin	NN
cord-023168-cd7adns8	800	18	gene	gene	NN
cord-023168-cd7adns8	800	19	sequence	sequence	NN
cord-023168-cd7adns8	800	20	and	and	CC
cord-023168-cd7adns8	800	21	its	-PRON-	PRP$
cord-023168-cd7adns8	800	22	promoter	promoter	NN
cord-023168-cd7adns8	800	23	region	region	NN
cord-023168-cd7adns8	800	24	into	into	IN
cord-023168-cd7adns8	800	25	mice	mouse	NNS
cord-023168-cd7adns8	800	26	stem	stem	NN
cord-023168-cd7adns8	800	27	cells	cell	NNS
cord-023168-cd7adns8	801	1	•	•	NNP
cord-023168-cd7adns8	802	1	β	β	LS
cord-023168-cd7adns8	802	2	-	-	:
cord-023168-cd7adns8	802	3	Globin	Globin	NNP
cord-023168-cd7adns8	802	4	gene	gene	NN
cord-023168-cd7adns8	802	5	transfer	transfer	NN
cord-023168-cd7adns8	802	6	into	into	IN
cord-023168-cd7adns8	802	7	progenitor	progenitor	JJ
cord-023168-cd7adns8	802	8	hematopoietic	hematopoietic	JJ
cord-023168-cd7adns8	802	9	cells	cell	NNS
cord-023168-cd7adns8	802	10	of	of	IN
cord-023168-cd7adns8	802	11	humans	human	NNS
cord-023168-cd7adns8	802	12	is	be	VBZ
cord-023168-cd7adns8	802	13	also	also	RB
cord-023168-cd7adns8	802	14	being	be	VBG
cord-023168-cd7adns8	802	15	studied	study	VBN
cord-023168-cd7adns8	803	1	•	•	NNP
cord-023168-cd7adns8	804	1	Other	other	JJ
cord-023168-cd7adns8	804	2	molecular	molecular	JJ
cord-023168-cd7adns8	804	3	approaches	approach	NNS
cord-023168-cd7adns8	804	4	being	be	VBG
cord-023168-cd7adns8	804	5	tried	try	VBN
cord-023168-cd7adns8	804	6	include	include	VBP
cord-023168-cd7adns8	804	7	using	use	VBG
cord-023168-cd7adns8	804	8	different	different	JJ
cord-023168-cd7adns8	804	9	mutations	mutation	NNS
cord-023168-cd7adns8	804	10	of	of	IN
cord-023168-cd7adns8	804	11	stop	stop	NN
cord-023168-cd7adns8	804	12	codons	codon	NNS
cord-023168-cd7adns8	804	13	and	and	CC
cord-023168-cd7adns8	804	14	aberrant	aberrant	JJ
cord-023168-cd7adns8	804	15	splicing	splicing	NN
cord-023168-cd7adns8	804	16	.	.	.
cord-023168-cd7adns8	805	1	Partner	partner	NN
cord-023168-cd7adns8	805	2	testing	testing	NN
cord-023168-cd7adns8	805	3	in	in	IN
cord-023168-cd7adns8	805	4	all	all	DT
cord-023168-cd7adns8	805	5	cases	case	NNS
cord-023168-cd7adns8	805	6	β	β	NN
cord-023168-cd7adns8	805	7	-	-	HYPH
cord-023168-cd7adns8	805	8	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	805	9	trait	trait	NN
cord-023168-cd7adns8	805	10	protecting	protect	VBG
cord-023168-cd7adns8	805	11	red	red	JJ
cord-023168-cd7adns8	805	12	cells	cell	NNS
cord-023168-cd7adns8	805	13	.	.	.
cord-023168-cd7adns8	806	1	Red	red	JJ
cord-023168-cd7adns8	806	2	cells	cell	NNS
cord-023168-cd7adns8	806	3	lack	lack	VBP
cord-023168-cd7adns8	806	4	any	any	DT
cord-023168-cd7adns8	806	5	other	other	JJ
cord-023168-cd7adns8	806	6	source	source	NN
cord-023168-cd7adns8	806	7	of	of	IN
cord-023168-cd7adns8	806	8	NADPH	NADPH	NNP
cord-023168-cd7adns8	806	9	and	and	CC
cord-023168-cd7adns8	806	10	are	be	VBP
cord-023168-cd7adns8	806	11	solely	solely	RB
cord-023168-cd7adns8	806	12	dependent	dependent	JJ
cord-023168-cd7adns8	806	13	on	on	IN
cord-023168-cd7adns8	806	14	the	the	DT
cord-023168-cd7adns8	806	15	pentose	pentose	NN
cord-023168-cd7adns8	806	16	phosphate	phosphate	NN
cord-023168-cd7adns8	806	17	pathway	pathway	NN
cord-023168-cd7adns8	806	18	so	so	IN
cord-023168-cd7adns8	806	19	G6PD	G6PD	NNP
cord-023168-cd7adns8	806	20	deficiency	deficiency	NN
cord-023168-cd7adns8	806	21	leaves	leave	VBZ
cord-023168-cd7adns8	806	22	these	these	DT
cord-023168-cd7adns8	806	23	cells	cell	NNS
cord-023168-cd7adns8	806	24	with	with	IN
cord-023168-cd7adns8	806	25	no	no	DT
cord-023168-cd7adns8	806	26	defence	defence	NN
cord-023168-cd7adns8	806	27	against	against	IN
cord-023168-cd7adns8	806	28	oxidative	oxidative	JJ
cord-023168-cd7adns8	806	29	damage	damage	NN
cord-023168-cd7adns8	806	30	.	.	.
cord-023168-cd7adns8	807	1	Oxidative	oxidative	JJ
cord-023168-cd7adns8	807	2	damage	damage	NN
cord-023168-cd7adns8	807	3	results	result	NNS
cord-023168-cd7adns8	807	4	in	in	IN
cord-023168-cd7adns8	807	5	denatured	denatured	JJ
cord-023168-cd7adns8	807	6	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	807	7	aggregates	aggregate	NNS
cord-023168-cd7adns8	807	8	which	which	WDT
cord-023168-cd7adns8	807	9	form	form	VBP
cord-023168-cd7adns8	807	10	Heinz	Heinz	NNP
cord-023168-cd7adns8	807	11	bodies	body	NNS
cord-023168-cd7adns8	807	12	(	(	-LRB-
cord-023168-cd7adns8	807	13	denatured	denature	VBN
cord-023168-cd7adns8	807	14	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	807	15	precipitates	precipitate	VBZ
cord-023168-cd7adns8	807	16	)	)	-RRB-
cord-023168-cd7adns8	807	17	.	.	.
cord-023168-cd7adns8	808	1	These	these	DT
cord-023168-cd7adns8	808	2	damaged	damage	VBN
cord-023168-cd7adns8	808	3	cells	cell	NNS
cord-023168-cd7adns8	808	4	bind	bind	VBP
cord-023168-cd7adns8	808	5	to	to	IN
cord-023168-cd7adns8	808	6	the	the	DT
cord-023168-cd7adns8	808	7	membrane	membrane	NN
cord-023168-cd7adns8	808	8	cytoskeleton	cytoskeleton	NN
cord-023168-cd7adns8	808	9	resulting	result	VBG
cord-023168-cd7adns8	808	10	in	in	IN
cord-023168-cd7adns8	808	11	decreased	decrease	VBN
cord-023168-cd7adns8	808	12	cellular	cellular	JJ
cord-023168-cd7adns8	808	13	deformability	deformability	NN
cord-023168-cd7adns8	808	14	,	,	,
cord-023168-cd7adns8	808	15	and	and	CC
cord-023168-cd7adns8	808	16	are	be	VBP
cord-023168-cd7adns8	808	17	also	also	RB
cord-023168-cd7adns8	808	18	destroyed	destroy	VBN
cord-023168-cd7adns8	808	19	in	in	IN
cord-023168-cd7adns8	808	20	the	the	DT
cord-023168-cd7adns8	808	21	spleen	spleen	NN
cord-023168-cd7adns8	808	22	,	,	,
cord-023168-cd7adns8	808	23	resulting	result	VBG
cord-023168-cd7adns8	808	24	in	in	IN
cord-023168-cd7adns8	808	25	haemolysis	haemolysis	NN
cord-023168-cd7adns8	808	26	.	.	.
cord-023168-cd7adns8	809	1	The	the	DT
cord-023168-cd7adns8	809	2	level	level	NN
cord-023168-cd7adns8	809	3	of	of	IN
cord-023168-cd7adns8	809	4	enzyme	enzyme	NN
cord-023168-cd7adns8	809	5	activity	activity	NN
cord-023168-cd7adns8	809	6	is	be	VBZ
cord-023168-cd7adns8	809	7	higher	high	JJR
cord-023168-cd7adns8	809	8	in	in	IN
cord-023168-cd7adns8	809	9	young	young	JJ
cord-023168-cd7adns8	809	10	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	809	11	than	than	IN
cord-023168-cd7adns8	809	12	in	in	IN
cord-023168-cd7adns8	809	13	more	more	JJR
cord-023168-cd7adns8	809	14	mature	mature	JJ
cord-023168-cd7adns8	809	15	cells	cell	NNS
cord-023168-cd7adns8	809	16	so	so	RB
cord-023168-cd7adns8	809	17	older	old	JJR
cord-023168-cd7adns8	809	18	cells	cell	NNS
cord-023168-cd7adns8	809	19	are	be	VBP
cord-023168-cd7adns8	809	20	more	more	RBR
cord-023168-cd7adns8	809	21	susceptible	susceptible	JJ
cord-023168-cd7adns8	809	22	to	to	IN
cord-023168-cd7adns8	809	23	haemolysis	haemolysis	NN
cord-023168-cd7adns8	809	24	.	.	.
cord-023168-cd7adns8	810	1	The	the	DT
cord-023168-cd7adns8	810	2	global	global	JJ
cord-023168-cd7adns8	810	3	distribution	distribution	NN
cord-023168-cd7adns8	810	4	of	of	IN
cord-023168-cd7adns8	810	5	G6PD	G6PD	NNP
cord-023168-cd7adns8	810	6	deficiency	deficiency	NN
cord-023168-cd7adns8	810	7	mirrors	mirror	VBZ
cord-023168-cd7adns8	810	8	that	that	WDT
cord-023168-cd7adns8	810	9	of	of	IN
cord-023168-cd7adns8	810	10	malaria	malaria	NN
cord-023168-cd7adns8	810	11	,	,	,
cord-023168-cd7adns8	810	12	and	and	CC
cord-023168-cd7adns8	810	13	where	where	WRB
cord-023168-cd7adns8	810	14	malaria	malaria	NN
cord-023168-cd7adns8	810	15	has	have	VBZ
cord-023168-cd7adns8	810	16	historically	historically	RB
cord-023168-cd7adns8	810	17	been	be	VBN
cord-023168-cd7adns8	810	18	prevalent	prevalent	JJ
cord-023168-cd7adns8	810	19	,	,	,
cord-023168-cd7adns8	810	20	and	and	CC
cord-023168-cd7adns8	810	21	it	-PRON-	PRP
cord-023168-cd7adns8	810	22	provides	provide	VBZ
cord-023168-cd7adns8	810	23	a	a	DT
cord-023168-cd7adns8	810	24	degree	degree	NN
cord-023168-cd7adns8	810	25	of	of	IN
cord-023168-cd7adns8	810	26	protection	protection	NN
cord-023168-cd7adns8	810	27	against	against	IN
cord-023168-cd7adns8	810	28	malaria	malaria	NN
cord-023168-cd7adns8	810	29	.	.	.
cord-023168-cd7adns8	811	1	181	181	CD
cord-023168-cd7adns8	812	1	•	•	NNP
cord-023168-cd7adns8	812	2	Class	Class	NNP
cord-023168-cd7adns8	812	3	IV	IV	NNP
cord-023168-cd7adns8	813	1	-Normal	-normal	JJ
cord-023168-cd7adns8	813	2	(	(	-LRB-
cord-023168-cd7adns8	813	3	60	60	CD
cord-023168-cd7adns8	813	4	-	-	SYM
cord-023168-cd7adns8	813	5	150	150	CD
cord-023168-cd7adns8	813	6	%	%	NN
cord-023168-cd7adns8	813	7	enzyme	enzyme	NN
cord-023168-cd7adns8	813	8	activity	activity	NN
cord-023168-cd7adns8	813	9	)	)	-RRB-
cord-023168-cd7adns8	814	1	•	•	NNP
cord-023168-cd7adns8	815	1	Class	class	NN
cord-023168-cd7adns8	815	2	V	v	NN
cord-023168-cd7adns8	815	3	-Increased	-increase	VBD
cord-023168-cd7adns8	815	4	activity	activity	NN
cord-023168-cd7adns8	815	5	(	(	-LRB-
cord-023168-cd7adns8	815	6	>	>	VBZ
cord-023168-cd7adns8	815	7	150	150	CD
cord-023168-cd7adns8	815	8	%	%	NN
cord-023168-cd7adns8	815	9	enzyme	enzyme	NN
cord-023168-cd7adns8	815	10	activity	activity	NN
cord-023168-cd7adns8	815	11	)	)	-RRB-
cord-023168-cd7adns8	815	12	.	.	.
cord-023168-cd7adns8	816	1	G6PD	G6PD	NNP
cord-023168-cd7adns8	816	2	enzyme	enzyme	NN
cord-023168-cd7adns8	816	3	variants	variant	NNS
cord-023168-cd7adns8	816	4	can	can	MD
cord-023168-cd7adns8	816	5	be	be	VB
cord-023168-cd7adns8	816	6	distinguished	distinguish	VBN
cord-023168-cd7adns8	816	7	by	by	IN
cord-023168-cd7adns8	816	8	their	-PRON-	PRP$
cord-023168-cd7adns8	816	9	electrophoretic	electrophoretic	JJ
cord-023168-cd7adns8	816	10	mobility	mobility	NN
cord-023168-cd7adns8	816	11	.	.	.
cord-023168-cd7adns8	817	1	184	184	CD
cord-023168-cd7adns8	817	2	G6PD	G6PD	NNP
cord-023168-cd7adns8	817	3	B	B	NNP
cord-023168-cd7adns8	817	4	,	,	,
cord-023168-cd7adns8	817	5	the	the	DT
cord-023168-cd7adns8	817	6	wild	wild	JJ
cord-023168-cd7adns8	817	7	-	-	HYPH
cord-023168-cd7adns8	817	8	type	type	NN
cord-023168-cd7adns8	817	9	enzyme	enzyme	NN
cord-023168-cd7adns8	817	10	,	,	,
cord-023168-cd7adns8	817	11	and	and	CC
cord-023168-cd7adns8	818	1	G6PD	G6PD	NNP
cord-023168-cd7adns8	818	2	A	A	NNP
cord-023168-cd7adns8	818	3	+	+	CC
cord-023168-cd7adns8	818	4	,	,	,
cord-023168-cd7adns8	818	5	a	a	DT
cord-023168-cd7adns8	818	6	common	common	JJ
cord-023168-cd7adns8	818	7	variant	variant	NN
cord-023168-cd7adns8	818	8	in	in	IN
cord-023168-cd7adns8	818	9	populations	population	NNS
cord-023168-cd7adns8	818	10	of	of	IN
cord-023168-cd7adns8	818	11	African	african	JJ
cord-023168-cd7adns8	818	12	descent	descent	NN
cord-023168-cd7adns8	818	13	,	,	,
cord-023168-cd7adns8	818	14	demonstrate	demonstrate	VBP
cord-023168-cd7adns8	818	15	normal	normal	JJ
cord-023168-cd7adns8	818	16	enzyme	enzyme	NN
cord-023168-cd7adns8	818	17	activity	activity	NN
cord-023168-cd7adns8	818	18	and	and	CC
cord-023168-cd7adns8	818	19	are	be	VBP
cord-023168-cd7adns8	818	20	not	not	RB
cord-023168-cd7adns8	818	21	associated	associate	VBN
cord-023168-cd7adns8	818	22	with	with	IN
cord-023168-cd7adns8	818	23	haemolysis	haemolysis	NN
cord-023168-cd7adns8	818	24	.	.	.
cord-023168-cd7adns8	819	1	G6PD	G6PD	NNP
cord-023168-cd7adns8	820	1	A	a	DT
cord-023168-cd7adns8	820	2	−	−	NN
cord-023168-cd7adns8	820	3	is	be	VBZ
cord-023168-cd7adns8	820	4	the	the	DT
cord-023168-cd7adns8	820	5	most	most	RBS
cord-023168-cd7adns8	820	6	common	common	JJ
cord-023168-cd7adns8	820	7	variant	variant	NN
cord-023168-cd7adns8	820	8	associated	associate	VBN
cord-023168-cd7adns8	820	9	with	with	IN
cord-023168-cd7adns8	820	10	mild	mild	JJ
cord-023168-cd7adns8	820	11	to	to	IN
cord-023168-cd7adns8	820	12	moderate	moderate	JJ
cord-023168-cd7adns8	820	13	haemolysis	haemolysis	NN
cord-023168-cd7adns8	820	14	with	with	IN
cord-023168-cd7adns8	820	15	approximately	approximately	RB
cord-023168-cd7adns8	820	16	10	10	CD
cord-023168-cd7adns8	820	17	-	-	SYM
cord-023168-cd7adns8	820	18	25	25	CD
cord-023168-cd7adns8	820	19	%	%	NN
cord-023168-cd7adns8	820	20	Hb	Hb	NNP
cord-023168-cd7adns8	820	21	E	E	NNP
cord-023168-cd7adns8	820	22	is	be	VBZ
cord-023168-cd7adns8	820	23	caused	cause	VBN
cord-023168-cd7adns8	820	24	by	by	IN
cord-023168-cd7adns8	820	25	a	a	DT
cord-023168-cd7adns8	820	26	substitution	substitution	NN
cord-023168-cd7adns8	820	27	of	of	IN
cord-023168-cd7adns8	820	28	glutamic	glutamic	NN
cord-023168-cd7adns8	820	29	acid	acid	NN
cord-023168-cd7adns8	820	30	by	by	IN
cord-023168-cd7adns8	820	31	lysine	lysine	NN
cord-023168-cd7adns8	820	32	at	at	IN
cord-023168-cd7adns8	820	33	codon	codon	NN
cord-023168-cd7adns8	820	34	26	26	CD
cord-023168-cd7adns8	820	35	of	of	IN
cord-023168-cd7adns8	820	36	the	the	DT
cord-023168-cd7adns8	820	37	β	β	NN
cord-023168-cd7adns8	820	38	-	-	HYPH
cord-023168-cd7adns8	820	39	globin	globin	NN
cord-023168-cd7adns8	820	40	gene	gene	NN
cord-023168-cd7adns8	820	41	.	.	.
cord-023168-cd7adns8	821	1	177	177	CD
cord-023168-cd7adns8	822	1	This	this	DT
cord-023168-cd7adns8	822	2	causes	cause	VBZ
cord-023168-cd7adns8	822	3	reduced	reduce	VBN
cord-023168-cd7adns8	822	4	synthesis	synthesis	NN
cord-023168-cd7adns8	822	5	of	of	IN
cord-023168-cd7adns8	822	6	the	the	DT
cord-023168-cd7adns8	822	7	β	β	NN
cord-023168-cd7adns8	822	8	-	-	HYPH
cord-023168-cd7adns8	822	9	E	e	NN
cord-023168-cd7adns8	822	10	chain	chain	NN
cord-023168-cd7adns8	822	11	and	and	CC
cord-023168-cd7adns8	822	12	leads	lead	VBZ
cord-023168-cd7adns8	822	13	to	to	IN
cord-023168-cd7adns8	822	14	a	a	DT
cord-023168-cd7adns8	822	15	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	822	16	phenotype	phenotype	NN
cord-023168-cd7adns8	822	17	.	.	.
cord-023168-cd7adns8	823	1	Hb	Hb	NNP
cord-023168-cd7adns8	823	2	E	E	NNP
cord-023168-cd7adns8	823	3	β	β	NN
cord-023168-cd7adns8	823	4	-	-	HYPH
cord-023168-cd7adns8	823	5	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	823	6	affects	affect	VBZ
cord-023168-cd7adns8	823	7	at	at	IN
cord-023168-cd7adns8	823	8	least	least	JJS
cord-023168-cd7adns8	823	9	a	a	DT
cord-023168-cd7adns8	823	10	million	million	CD
cord-023168-cd7adns8	823	11	people	people	NNS
cord-023168-cd7adns8	823	12	worldwide	worldwide	RB
cord-023168-cd7adns8	823	13	and	and	CC
cord-023168-cd7adns8	823	14	is	be	VBZ
cord-023168-cd7adns8	823	15	an	an	DT
cord-023168-cd7adns8	823	16	important	important	JJ
cord-023168-cd7adns8	823	17	health	health	NN
cord-023168-cd7adns8	823	18	problem	problem	NN
cord-023168-cd7adns8	823	19	particularly	particularly	RB
cord-023168-cd7adns8	823	20	in	in	IN
cord-023168-cd7adns8	823	21	the	the	DT
cord-023168-cd7adns8	823	22	Indian	indian	JJ
cord-023168-cd7adns8	823	23	subcontinent	subcontinent	NN
cord-023168-cd7adns8	823	24	and	and	CC
cord-023168-cd7adns8	823	25	South	South	NNP
cord-023168-cd7adns8	823	26	-	-	HYPH
cord-023168-cd7adns8	823	27	east	east	NN
cord-023168-cd7adns8	823	28	Asia	Asia	NNP
cord-023168-cd7adns8	823	29	.	.	.
cord-023168-cd7adns8	824	1	In	in	IN
cord-023168-cd7adns8	824	2	some	some	DT
cord-023168-cd7adns8	824	3	areas	area	NNS
cord-023168-cd7adns8	824	4	,	,	,
cord-023168-cd7adns8	824	5	it	-PRON-	PRP
cord-023168-cd7adns8	824	6	has	have	VBZ
cord-023168-cd7adns8	824	7	replaced	replace	VBN
cord-023168-cd7adns8	824	8	β	β	NN
cord-023168-cd7adns8	824	9	-	-	HYPH
cord-023168-cd7adns8	824	10	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	824	11	as	as	IN
cord-023168-cd7adns8	824	12	the	the	DT
cord-023168-cd7adns8	824	13	most	most	RBS
cord-023168-cd7adns8	824	14	common	common	JJ
cord-023168-cd7adns8	824	15	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	824	16	disorder	disorder	NN
cord-023168-cd7adns8	824	17	.	.	.
cord-023168-cd7adns8	825	1	The	the	DT
cord-023168-cd7adns8	825	2	frequency	frequency	NN
cord-023168-cd7adns8	825	3	of	of	IN
cord-023168-cd7adns8	825	4	HbE	hbe	NN
cord-023168-cd7adns8	825	5	reaches	reach	VBZ
cord-023168-cd7adns8	825	6	60	60	CD
cord-023168-cd7adns8	825	7	%	%	NN
cord-023168-cd7adns8	825	8	in	in	IN
cord-023168-cd7adns8	825	9	many	many	JJ
cord-023168-cd7adns8	825	10	regions	region	NNS
cord-023168-cd7adns8	825	11	of	of	IN
cord-023168-cd7adns8	825	12	Thailand	Thailand	NNP
cord-023168-cd7adns8	825	13	,	,	,
cord-023168-cd7adns8	825	14	Laos	Laos	NNP
cord-023168-cd7adns8	825	15	and	and	CC
cord-023168-cd7adns8	825	16	Cambodia	Cambodia	NNP
cord-023168-cd7adns8	825	17	with	with	IN
cord-023168-cd7adns8	825	18	estimates	estimate	NNS
cord-023168-cd7adns8	825	19	of	of	IN
cord-023168-cd7adns8	825	20	at	at	RB
cord-023168-cd7adns8	825	21	least	least	JJS
cord-023168-cd7adns8	825	22	100	100	CD
cord-023168-cd7adns8	825	23	000	000	CD
cord-023168-cd7adns8	825	24	new	new	JJ
cord-023168-cd7adns8	825	25	cases	case	NNS
cord-023168-cd7adns8	825	26	of	of	IN
cord-023168-cd7adns8	825	27	HbE	HbE	NNP
cord-023168-cd7adns8	825	28	β	β	NNP
cord-023168-cd7adns8	825	29	-	-	HYPH
cord-023168-cd7adns8	825	30	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	825	31	expected	expect	VBN
cord-023168-cd7adns8	825	32	in	in	IN
cord-023168-cd7adns8	825	33	the	the	DT
cord-023168-cd7adns8	825	34	next	next	JJ
cord-023168-cd7adns8	825	35	few	few	JJ
cord-023168-cd7adns8	825	36	decades	decade	NNS
cord-023168-cd7adns8	825	37	in	in	IN
cord-023168-cd7adns8	825	38	Thailand	Thailand	NNP
cord-023168-cd7adns8	825	39	alone	alone	JJ
cord-023168-cd7adns8	825	40	.	.	.
cord-023168-cd7adns8	826	1	The	the	DT
cord-023168-cd7adns8	826	2	natural	natural	JJ
cord-023168-cd7adns8	826	3	history	history	NN
cord-023168-cd7adns8	826	4	of	of	IN
cord-023168-cd7adns8	826	5	HbE	HbE	NNP
cord-023168-cd7adns8	826	6	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	826	7	is	be	VBZ
cord-023168-cd7adns8	826	8	highly	highly	RB
cord-023168-cd7adns8	826	9	variable	variable	JJ
cord-023168-cd7adns8	826	10	;	;	:
cord-023168-cd7adns8	826	11	some	some	DT
cord-023168-cd7adns8	826	12	patients	patient	NNS
cord-023168-cd7adns8	826	13	are	be	VBP
cord-023168-cd7adns8	826	14	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	826	15	(	(	-LRB-
cord-023168-cd7adns8	826	16	e.g.	e.g.	IN
cord-023168-cd7adns8	826	17	heterozygotes	heterozygote	NNS
cord-023168-cd7adns8	826	18	,	,	,
cord-023168-cd7adns8	826	19	HbE	HbE	NNP
cord-023168-cd7adns8	826	20	20	20	CD
cord-023168-cd7adns8	826	21	-	-	SYM
cord-023168-cd7adns8	826	22	30	30	CD
cord-023168-cd7adns8	826	23	%	%	NN
cord-023168-cd7adns8	826	24	or	or	CC
cord-023168-cd7adns8	826	25	homozygotes	homozygote	NNS
cord-023168-cd7adns8	826	26	HbE	hbe	NN
cord-023168-cd7adns8	826	27	,	,	,
cord-023168-cd7adns8	826	28	80	80	CD
cord-023168-cd7adns8	826	29	-	-	SYM
cord-023168-cd7adns8	826	30	90	90	CD
cord-023168-cd7adns8	826	31	%	%	NN
cord-023168-cd7adns8	826	32	)	)	-RRB-
cord-023168-cd7adns8	826	33	while	while	IN
cord-023168-cd7adns8	826	34	others	other	NNS
cord-023168-cd7adns8	826	35	(	(	-LRB-
cord-023168-cd7adns8	826	36	e.g.	e.g.	IN
cord-023168-cd7adns8	826	37	HbE	hbe	NN
cord-023168-cd7adns8	826	38	with	with	IN
cord-023168-cd7adns8	826	39	β	β	NN
cord-023168-cd7adns8	826	40	-	-	HYPH
cord-023168-cd7adns8	826	41	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	826	42	)	)	-RRB-
cord-023168-cd7adns8	826	43	may	may	MD
cord-023168-cd7adns8	826	44	be	be	VB
cord-023168-cd7adns8	826	45	transfusiondependent	transfusiondependent	NN
cord-023168-cd7adns8	826	46	.	.	.
cord-023168-cd7adns8	827	1	PATHOPHYSIOLOGY	PATHOPHYSIOLOGY	NNP
cord-023168-cd7adns8	827	2	Glucose-6-phosphate	Glucose-6-phosphate	NNP
cord-023168-cd7adns8	827	3	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	827	4	(	(	-LRB-
cord-023168-cd7adns8	827	5	G6PD	G6PD	NNP
cord-023168-cd7adns8	827	6	)	)	-RRB-
cord-023168-cd7adns8	827	7	deficiency	deficiency	NN
cord-023168-cd7adns8	827	8	was	be	VBD
cord-023168-cd7adns8	827	9	originally	originally	RB
cord-023168-cd7adns8	827	10	recognized	recognize	VBN
cord-023168-cd7adns8	827	11	through	through	IN
cord-023168-cd7adns8	827	12	its	-PRON-	PRP$
cord-023168-cd7adns8	827	13	association	association	NN
cord-023168-cd7adns8	827	14	with	with	IN
cord-023168-cd7adns8	827	15	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	827	16	related	relate	VBN
cord-023168-cd7adns8	827	17	to	to	IN
cord-023168-cd7adns8	827	18	eating	eat	VBG
cord-023168-cd7adns8	827	19	fava	fava	NN
cord-023168-cd7adns8	827	20	beans	bean	NNS
cord-023168-cd7adns8	827	21	(	(	-LRB-
cord-023168-cd7adns8	827	22	'	'	``
cord-023168-cd7adns8	827	23	favism	favism	NN
cord-023168-cd7adns8	827	24	'	'	''
cord-023168-cd7adns8	827	25	)	)	-RRB-
cord-023168-cd7adns8	827	26	and	and	CC
cord-023168-cd7adns8	827	27	primaquine	primaquine	NN
cord-023168-cd7adns8	827	28	ingestion	ingestion	NN
cord-023168-cd7adns8	827	29	.	.	.
cord-023168-cd7adns8	828	1	178	178	CD
cord-023168-cd7adns8	828	2	G6PD	G6PD	NNP
cord-023168-cd7adns8	828	3	deficiency	deficiency	NN
cord-023168-cd7adns8	828	4	is	be	VBZ
cord-023168-cd7adns8	828	5	the	the	DT
cord-023168-cd7adns8	828	6	most	most	RBS
cord-023168-cd7adns8	828	7	common	common	JJ
cord-023168-cd7adns8	828	8	enzyme	enzyme	NN
cord-023168-cd7adns8	828	9	defect	defect	NN
cord-023168-cd7adns8	828	10	in	in	IN
cord-023168-cd7adns8	828	11	humans	human	NNS
cord-023168-cd7adns8	828	12	and	and	CC
cord-023168-cd7adns8	828	13	is	be	VBZ
cord-023168-cd7adns8	828	14	present	present	JJ
cord-023168-cd7adns8	828	15	in	in	IN
cord-023168-cd7adns8	828	16	about	about	RB
cord-023168-cd7adns8	828	17	400	400	CD
cord-023168-cd7adns8	828	18	million	million	CD
cord-023168-cd7adns8	828	19	people	people	NNS
cord-023168-cd7adns8	828	20	worldwide	worldwide	RB
cord-023168-cd7adns8	828	21	(	(	-LRB-
cord-023168-cd7adns8	828	22	Figure	figure	NN
cord-023168-cd7adns8	828	23	65	65	CD
cord-023168-cd7adns8	828	24	.10	.10	CD
cord-023168-cd7adns8	828	25	)	)	-RRB-
cord-023168-cd7adns8	828	26	.	.	.
cord-023168-cd7adns8	829	1	179	179	CD
cord-023168-cd7adns8	829	2	,	,	,
cord-023168-cd7adns8	829	3	180	180	CD
cord-023168-cd7adns8	830	1	It	-PRON-	PRP
cord-023168-cd7adns8	830	2	is	be	VBZ
cord-023168-cd7adns8	830	3	an	an	DT
cord-023168-cd7adns8	830	4	X	x	NN
cord-023168-cd7adns8	830	5	-	-	HYPH
cord-023168-cd7adns8	830	6	linked	link	VBN
cord-023168-cd7adns8	830	7	,	,	,
cord-023168-cd7adns8	830	8	hereditary	hereditary	JJ
cord-023168-cd7adns8	830	9	defect	defect	NN
cord-023168-cd7adns8	830	10	caused	cause	VBN
cord-023168-cd7adns8	830	11	by	by	IN
cord-023168-cd7adns8	830	12	mutations	mutation	NNS
cord-023168-cd7adns8	830	13	in	in	IN
cord-023168-cd7adns8	830	14	the	the	DT
cord-023168-cd7adns8	830	15	G6PD	G6PD	NNP
cord-023168-cd7adns8	830	16	gene	gene	NN
cord-023168-cd7adns8	830	17	.	.	.
cord-023168-cd7adns8	831	1	G6PD	G6PD	NNP
cord-023168-cd7adns8	831	2	is	be	VBZ
cord-023168-cd7adns8	831	3	an	an	DT
cord-023168-cd7adns8	831	4	enzyme	enzyme	NN
cord-023168-cd7adns8	831	5	that	that	WDT
cord-023168-cd7adns8	831	6	catalyses	catalyse	VBZ
cord-023168-cd7adns8	831	7	the	the	DT
cord-023168-cd7adns8	831	8	first	first	JJ
cord-023168-cd7adns8	831	9	reaction	reaction	NN
cord-023168-cd7adns8	831	10	in	in	IN
cord-023168-cd7adns8	831	11	the	the	DT
cord-023168-cd7adns8	831	12	pentose	pentose	NN
cord-023168-cd7adns8	831	13	phosphate	phosphate	NN
cord-023168-cd7adns8	831	14	pathway	pathway	NN
cord-023168-cd7adns8	831	15	,	,	,
cord-023168-cd7adns8	831	16	to	to	TO
cord-023168-cd7adns8	831	17	produce	produce	VB
cord-023168-cd7adns8	831	18	NADPH	NADPH	NNP
cord-023168-cd7adns8	831	19	,	,	,
cord-023168-cd7adns8	831	20	which	which	WDT
cord-023168-cd7adns8	831	21	is	be	VBZ
cord-023168-cd7adns8	831	22	an	an	DT
cord-023168-cd7adns8	831	23	important	important	JJ
cord-023168-cd7adns8	831	24	antioxidant	antioxidant	NN
cord-023168-cd7adns8	831	25	used	use	VBN
cord-023168-cd7adns8	831	26	to	to	TO
cord-023168-cd7adns8	831	27	preserve	preserve	VB
cord-023168-cd7adns8	831	28	the	the	DT
cord-023168-cd7adns8	831	29	reduced	reduce	VBN
cord-023168-cd7adns8	831	30	form	form	NN
cord-023168-cd7adns8	831	31	of	of	IN
cord-023168-cd7adns8	831	32	glutathione	glutathione	NN
cord-023168-cd7adns8	831	33	.	.	.
cord-023168-cd7adns8	832	1	178	178	CD
cord-023168-cd7adns8	832	2	,	,	,
cord-023168-cd7adns8	832	3	181	181	CD
cord-023168-cd7adns8	832	4	Reduced	reduce	VBN
cord-023168-cd7adns8	832	5	glutathione	glutathione	NN
cord-023168-cd7adns8	832	6	acts	act	VBZ
cord-023168-cd7adns8	832	7	as	as	IN
cord-023168-cd7adns8	832	8	a	a	DT
cord-023168-cd7adns8	832	9	scavenger	scavenger	NN
cord-023168-cd7adns8	832	10	for	for	IN
cord-023168-cd7adns8	832	11	oxidative	oxidative	JJ
cord-023168-cd7adns8	832	12	metabolites	metabolite	NNS
cord-023168-cd7adns8	832	13	thereby	thereby	RB
cord-023168-cd7adns8	832	14	<	<	XX
cord-023168-cd7adns8	832	15	0.5	0.5	CD
cord-023168-cd7adns8	832	16	%	%	NN
cord-023168-cd7adns8	832	17	0.5	0.5	CD
cord-023168-cd7adns8	832	18	-	-	SYM
cord-023168-cd7adns8	832	19	2.9	2.9	CD
cord-023168-cd7adns8	832	20	%	%	NN
cord-023168-cd7adns8	832	21	3	3	CD
cord-023168-cd7adns8	832	22	-	-	SYM
cord-023168-cd7adns8	832	23	6.9	6.9	CD
cord-023168-cd7adns8	832	24	%	%	NN
cord-023168-cd7adns8	832	25	7	7	CD
cord-023168-cd7adns8	832	26	-	-	SYM
cord-023168-cd7adns8	832	27	9.9	9.9	CD
cord-023168-cd7adns8	832	28	%	%	NN
cord-023168-cd7adns8	832	29	10	10	CD
cord-023168-cd7adns8	832	30	-	-	SYM
cord-023168-cd7adns8	832	31	11.9	11.9	CD
cord-023168-cd7adns8	832	32	%	%	NN
cord-023168-cd7adns8	832	33	15	15	CD
cord-023168-cd7adns8	832	34	-	-	SYM
cord-023168-cd7adns8	832	35	25	25	CD
cord-023168-cd7adns8	832	36	%	%	NN
cord-023168-cd7adns8	832	37	of	of	IN
cord-023168-cd7adns8	832	38	Africans	Africans	NNPS
cord-023168-cd7adns8	832	39	carrying	carry	VBG
cord-023168-cd7adns8	832	40	this	this	DT
cord-023168-cd7adns8	832	41	variant	variant	NN
cord-023168-cd7adns8	832	42	.	.	.
cord-023168-cd7adns8	833	1	G6PD	G6PD	NNP
cord-023168-cd7adns8	833	2	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	833	3	,	,	,
cord-023168-cd7adns8	833	4	present	present	JJ
cord-023168-cd7adns8	833	5	in	in	IN
cord-023168-cd7adns8	833	6	all	all	DT
cord-023168-cd7adns8	833	7	countries	country	NNS
cord-023168-cd7adns8	833	8	surrounding	surround	VBG
cord-023168-cd7adns8	833	9	the	the	DT
cord-023168-cd7adns8	833	10	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	833	11	Sea	Sea	NNP
cord-023168-cd7adns8	833	12	,	,	,
cord-023168-cd7adns8	833	13	Middle	Middle	NNP
cord-023168-cd7adns8	833	14	East	East	NNP
cord-023168-cd7adns8	833	15	,	,	,
cord-023168-cd7adns8	833	16	India	India	NNP
cord-023168-cd7adns8	833	17	and	and	CC
cord-023168-cd7adns8	833	18	Indonesia	Indonesia	NNP
cord-023168-cd7adns8	833	19	,	,	,
cord-023168-cd7adns8	833	20	has	have	VBZ
cord-023168-cd7adns8	833	21	the	the	DT
cord-023168-cd7adns8	833	22	same	same	JJ
cord-023168-cd7adns8	833	23	electrophoretic	electrophoretic	JJ
cord-023168-cd7adns8	833	24	mobility	mobility	NN
cord-023168-cd7adns8	833	25	as	as	IN
cord-023168-cd7adns8	833	26	G6PD	G6PD	NNP
cord-023168-cd7adns8	833	27	B	B	NNP
cord-023168-cd7adns8	834	1	but	but	CC
cord-023168-cd7adns8	834	2	the	the	DT
cord-023168-cd7adns8	834	3	enzyme	enzyme	NN
cord-023168-cd7adns8	834	4	synthesis	synthesis	NN
cord-023168-cd7adns8	834	5	and	and	CC
cord-023168-cd7adns8	834	6	catalytic	catalytic	JJ
cord-023168-cd7adns8	834	7	activity	activity	NN
cord-023168-cd7adns8	834	8	are	be	VBP
cord-023168-cd7adns8	834	9	reduced	reduce	VBN
cord-023168-cd7adns8	834	10	.	.	.
cord-023168-cd7adns8	835	1	In	in	IN
cord-023168-cd7adns8	835	2	several	several	JJ
cord-023168-cd7adns8	835	3	populations	population	NNS
cord-023168-cd7adns8	835	4	,	,	,
cord-023168-cd7adns8	835	5	G6PD	G6PD	NNP
cord-023168-cd7adns8	835	6	A	A	NNP
cord-023168-cd7adns8	835	7	−	−	NNP
cord-023168-cd7adns8	835	8	and	and	CC
cord-023168-cd7adns8	836	1	G6PD	G6PD	NNP
cord-023168-cd7adns8	836	2	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	836	3	co	co	NN
cord-023168-cd7adns8	836	4	-	-	NN
cord-023168-cd7adns8	836	5	exist	exist	VB
cord-023168-cd7adns8	836	6	.	.	.
cord-023168-cd7adns8	837	1	The	the	DT
cord-023168-cd7adns8	837	2	clinical	clinical	JJ
cord-023168-cd7adns8	837	3	manifestations	manifestation	NNS
cord-023168-cd7adns8	837	4	of	of	IN
cord-023168-cd7adns8	837	5	G6PD	G6PD	NNP
cord-023168-cd7adns8	837	6	deficiency	deficiency	NN
cord-023168-cd7adns8	837	7	can	can	MD
cord-023168-cd7adns8	837	8	be	be	VB
cord-023168-cd7adns8	837	9	classified	classify	VBN
cord-023168-cd7adns8	837	10	into	into	IN
cord-023168-cd7adns8	837	11	:	:	:
cord-023168-cd7adns8	837	12	(	(	-LRB-
cord-023168-cd7adns8	837	13	i	i	NN
cord-023168-cd7adns8	837	14	)	)	-RRB-
cord-023168-cd7adns8	837	15	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	837	16	;	;	:
cord-023168-cd7adns8	837	17	(	(	-LRB-
cord-023168-cd7adns8	837	18	ii	ii	NN
cord-023168-cd7adns8	837	19	)	)	-RRB-
cord-023168-cd7adns8	837	20	acute	acute	JJ
cord-023168-cd7adns8	837	21	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	837	22	anaemia	anaemia	NN
cord-023168-cd7adns8	837	23	;	;	,
cord-023168-cd7adns8	837	24	(	(	-LRB-
cord-023168-cd7adns8	837	25	iii	iii	NN
cord-023168-cd7adns8	837	26	)	)	-RRB-
cord-023168-cd7adns8	837	27	favism	favism	NNP
cord-023168-cd7adns8	837	28	;	;	,
cord-023168-cd7adns8	837	29	(	(	-LRB-
cord-023168-cd7adns8	837	30	iv	iv	LS
cord-023168-cd7adns8	837	31	)	)	-RRB-
cord-023168-cd7adns8	837	32	neonatal	neonatal	JJ
cord-023168-cd7adns8	837	33	jaundice	jaundice	NN
cord-023168-cd7adns8	837	34	;	;	:
cord-023168-cd7adns8	837	35	and	and	CC
cord-023168-cd7adns8	837	36	(	(	-LRB-
cord-023168-cd7adns8	837	37	v	v	LS
cord-023168-cd7adns8	837	38	)	)	-RRB-
cord-023168-cd7adns8	837	39	chronic	chronic	JJ
cord-023168-cd7adns8	837	40	non	non	JJ
cord-023168-cd7adns8	837	41	-	-	JJ
cord-023168-cd7adns8	837	42	spherocytic	spherocytic	JJ
cord-023168-cd7adns8	837	43	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	837	44	anaemia	anaemia	NN
cord-023168-cd7adns8	837	45	.	.	.
cord-023168-cd7adns8	838	1	Acute	acute	JJ
cord-023168-cd7adns8	838	2	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	838	3	anaemia	anaemia	NN
cord-023168-cd7adns8	838	4	in	in	IN
cord-023168-cd7adns8	838	5	G6PD	G6PD	NNP
cord-023168-cd7adns8	838	6	deficiency	deficiency	NN
cord-023168-cd7adns8	838	7	can	can	MD
cord-023168-cd7adns8	838	8	be	be	VB
cord-023168-cd7adns8	838	9	secondary	secondary	JJ
cord-023168-cd7adns8	838	10	to	to	IN
cord-023168-cd7adns8	838	11	infection	infection	NN
cord-023168-cd7adns8	838	12	(	(	-LRB-
cord-023168-cd7adns8	838	13	e.g.	e.g.	RB
cord-023168-cd7adns8	838	14	pneumonia	pneumonia	NN
cord-023168-cd7adns8	838	15	,	,	,
cord-023168-cd7adns8	838	16	hepatitis	hepatitis	NNP
cord-023168-cd7adns8	838	17	A	A	NNP
cord-023168-cd7adns8	838	18	and	and	CC
cord-023168-cd7adns8	838	19	B	b	NN
cord-023168-cd7adns8	838	20	,	,	,
cord-023168-cd7adns8	838	21	and	and	CC
cord-023168-cd7adns8	838	22	typhoid	typhoid	NN
cord-023168-cd7adns8	838	23	fever	fever	NN
cord-023168-cd7adns8	838	24	)	)	-RRB-
cord-023168-cd7adns8	838	25	or	or	CC
cord-023168-cd7adns8	838	26	oxidant	oxidant	JJ
cord-023168-cd7adns8	838	27	drugs	drug	NNS
cord-023168-cd7adns8	838	28	,	,	,
cord-023168-cd7adns8	838	29	or	or	CC
cord-023168-cd7adns8	838	30	may	may	MD
cord-023168-cd7adns8	838	31	be	be	VB
cord-023168-cd7adns8	838	32	precipitated	precipitate	VBN
cord-023168-cd7adns8	838	33	by	by	IN
cord-023168-cd7adns8	838	34	diabetic	diabetic	JJ
cord-023168-cd7adns8	838	35	ketoacidosis	ketoacidosis	NN
cord-023168-cd7adns8	838	36	,	,	,
cord-023168-cd7adns8	838	37	myocardial	myocardial	JJ
cord-023168-cd7adns8	838	38	infarction	infarction	NN
cord-023168-cd7adns8	838	39	and	and	CC
cord-023168-cd7adns8	838	40	strenuous	strenuous	JJ
cord-023168-cd7adns8	838	41	physical	physical	JJ
cord-023168-cd7adns8	838	42	exercise	exercise	NN
cord-023168-cd7adns8	838	43	.	.	.
cord-023168-cd7adns8	839	1	185	185	CD
cord-023168-cd7adns8	839	2	,	,	,
cord-023168-cd7adns8	839	3	186	186	CD
cord-023168-cd7adns8	840	1	A	a	DT
cord-023168-cd7adns8	840	2	list	list	NN
cord-023168-cd7adns8	840	3	of	of	IN
cord-023168-cd7adns8	840	4	the	the	DT
cord-023168-cd7adns8	840	5	drugs	drug	NNS
cord-023168-cd7adns8	840	6	which	which	WDT
cord-023168-cd7adns8	840	7	may	may	MD
cord-023168-cd7adns8	840	8	cause	cause	VB
cord-023168-cd7adns8	840	9	haemolysis	haemolysis	NN
cord-023168-cd7adns8	840	10	in	in	IN
cord-023168-cd7adns8	840	11	G6PD	G6PD	NNP
cord-023168-cd7adns8	840	12	-	-	HYPH
cord-023168-cd7adns8	840	13	deficient	deficient	JJ
cord-023168-cd7adns8	840	14	individuals	individual	NNS
cord-023168-cd7adns8	840	15	(	(	-LRB-
cord-023168-cd7adns8	840	16	Table	table	NN
cord-023168-cd7adns8	840	17	65	65	CD
cord-023168-cd7adns8	840	18	.9	.9	NFP
cord-023168-cd7adns8	840	19	)	)	-RRB-
cord-023168-cd7adns8	841	1	187	187	CD
cord-023168-cd7adns8	841	2	can	can	MD
cord-023168-cd7adns8	841	3	be	be	VB
cord-023168-cd7adns8	841	4	obtained	obtain	VBN
cord-023168-cd7adns8	841	5	from	from	IN
cord-023168-cd7adns8	841	6	:	:	:
cord-023168-cd7adns8	841	7	http://www.g6pd.org/favism/english/index.mv	http://www.g6pd.org/favism/english/index.mv	CD
cord-023168-cd7adns8	841	8	.	.	.
cord-023168-cd7adns8	842	1	A	a	DT
cord-023168-cd7adns8	842	2	drug	drug	NN
cord-023168-cd7adns8	842	3	which	which	WDT
cord-023168-cd7adns8	842	4	is	be	VBZ
cord-023168-cd7adns8	842	5	deemed	deem	VBN
cord-023168-cd7adns8	842	6	to	to	TO
cord-023168-cd7adns8	842	7	be	be	VB
cord-023168-cd7adns8	842	8	safe	safe	JJ
cord-023168-cd7adns8	842	9	for	for	IN
cord-023168-cd7adns8	842	10	some	some	DT
cord-023168-cd7adns8	842	11	G6PD	G6PD	NNP
cord-023168-cd7adns8	842	12	-	-	HYPH
cord-023168-cd7adns8	842	13	deficient	deficient	JJ
cord-023168-cd7adns8	842	14	individuals	individual	NNS
cord-023168-cd7adns8	842	15	may	may	MD
cord-023168-cd7adns8	842	16	cause	cause	VB
cord-023168-cd7adns8	842	17	haemolysis	haemolysis	NN
cord-023168-cd7adns8	842	18	in	in	IN
cord-023168-cd7adns8	842	19	others	other	NNS
cord-023168-cd7adns8	842	20	due	due	JJ
cord-023168-cd7adns8	842	21	to	to	IN
cord-023168-cd7adns8	842	22	the	the	DT
cord-023168-cd7adns8	842	23	heterogeneity	heterogeneity	NN
cord-023168-cd7adns8	842	24	of	of	IN
cord-023168-cd7adns8	842	25	the	the	DT
cord-023168-cd7adns8	842	26	underlying	underlying	JJ
cord-023168-cd7adns8	842	27	genetic	genetic	JJ
cord-023168-cd7adns8	842	28	variants	variant	NNS
cord-023168-cd7adns8	842	29	.	.	.
cord-023168-cd7adns8	843	1	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	843	2	typically	typically	RB
cord-023168-cd7adns8	843	3	occurs	occur	VBZ
cord-023168-cd7adns8	843	4	within	within	IN
cord-023168-cd7adns8	843	5	1	1	CD
cord-023168-cd7adns8	843	6	-	-	SYM
cord-023168-cd7adns8	843	7	3	3	CD
cord-023168-cd7adns8	843	8	days	day	NNS
cord-023168-cd7adns8	843	9	after	after	IN
cord-023168-cd7adns8	843	10	commencing	commence	VBG
cord-023168-cd7adns8	843	11	the	the	DT
cord-023168-cd7adns8	843	12	drug	drug	NN
cord-023168-cd7adns8	843	13	and	and	CC
cord-023168-cd7adns8	843	14	can	can	MD
cord-023168-cd7adns8	843	15	produce	produce	VB
cord-023168-cd7adns8	843	16	intense	intense	JJ
cord-023168-cd7adns8	843	17	haemoglobinuria	haemoglobinuria	NNS
cord-023168-cd7adns8	843	18	.	.	.
cord-023168-cd7adns8	844	1	Fortunately	fortunately	RB
cord-023168-cd7adns8	844	2	,	,	,
cord-023168-cd7adns8	844	3	the	the	DT
cord-023168-cd7adns8	844	4	disorder	disorder	NN
cord-023168-cd7adns8	844	5	is	be	VBZ
cord-023168-cd7adns8	844	6	self	self	NN
cord-023168-cd7adns8	844	7	-	-	HYPH
cord-023168-cd7adns8	844	8	limiting	limit	VBG
cord-023168-cd7adns8	844	9	and	and	CC
cord-023168-cd7adns8	844	10	most	most	JJS
cord-023168-cd7adns8	844	11	patients	patient	NNS
cord-023168-cd7adns8	844	12	do	do	VBP
cord-023168-cd7adns8	844	13	not	not	RB
cord-023168-cd7adns8	844	14	develop	develop	VB
cord-023168-cd7adns8	844	15	renal	renal	JJ
cord-023168-cd7adns8	844	16	impairment	impairment	NN
cord-023168-cd7adns8	844	17	or	or	CC
cord-023168-cd7adns8	844	18	anaemia	anaemia	NN
cord-023168-cd7adns8	844	19	requiring	require	VBG
cord-023168-cd7adns8	844	20	transfusion	transfusion	NN
cord-023168-cd7adns8	844	21	.	.	.
cord-023168-cd7adns8	845	1	The	the	DT
cord-023168-cd7adns8	845	2	spontaneous	spontaneous	JJ
cord-023168-cd7adns8	845	3	recovery	recovery	NN
cord-023168-cd7adns8	845	4	reflects	reflect	VBZ
cord-023168-cd7adns8	845	5	replacement	replacement	NN
cord-023168-cd7adns8	845	6	of	of	IN
cord-023168-cd7adns8	845	7	the	the	DT
cord-023168-cd7adns8	845	8	older	old	JJR
cord-023168-cd7adns8	845	9	,	,	,
cord-023168-cd7adns8	845	10	enzyme	enzyme	NN
cord-023168-cd7adns8	845	11	-	-	HYPH
cord-023168-cd7adns8	845	12	deficient	deficient	JJ
cord-023168-cd7adns8	845	13	red	red	JJ
cord-023168-cd7adns8	845	14	cells	cell	NNS
cord-023168-cd7adns8	845	15	by	by	IN
cord-023168-cd7adns8	845	16	younger	young	JJR
cord-023168-cd7adns8	845	17	reticulocytes	reticulocyte	NNS
cord-023168-cd7adns8	845	18	which	which	WDT
cord-023168-cd7adns8	845	19	can	can	MD
cord-023168-cd7adns8	845	20	withstand	withstand	VB
cord-023168-cd7adns8	845	21	oxidative	oxidative	JJ
cord-023168-cd7adns8	845	22	injury	injury	NN
cord-023168-cd7adns8	845	23	.	.	.
cord-023168-cd7adns8	846	1	186	186	CD
cord-023168-cd7adns8	847	1	If	if	IN
cord-023168-cd7adns8	847	2	the	the	DT
cord-023168-cd7adns8	847	3	precipitating	precipitate	VBG
cord-023168-cd7adns8	847	4	cause	cause	NN
cord-023168-cd7adns8	847	5	has	have	VBZ
cord-023168-cd7adns8	847	6	been	be	VBN
cord-023168-cd7adns8	847	7	removed	remove	VBN
cord-023168-cd7adns8	847	8	the	the	DT
cord-023168-cd7adns8	847	9	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	847	10	begins	begin	VBZ
cord-023168-cd7adns8	847	11	to	to	TO
cord-023168-cd7adns8	847	12	recover	recover	VB
cord-023168-cd7adns8	847	13	after	after	IN
cord-023168-cd7adns8	847	14	8	8	CD
cord-023168-cd7adns8	847	15	-	-	SYM
cord-023168-cd7adns8	847	16	10	10	CD
cord-023168-cd7adns8	847	17	days	day	NNS
cord-023168-cd7adns8	847	18	.	.	.
cord-023168-cd7adns8	848	1	Acute	acute	JJ
cord-023168-cd7adns8	848	2	renal	renal	JJ
cord-023168-cd7adns8	848	3	failure	failure	NN
cord-023168-cd7adns8	848	4	due	due	JJ
cord-023168-cd7adns8	848	5	to	to	IN
cord-023168-cd7adns8	848	6	acute	acute	JJ
cord-023168-cd7adns8	848	7	tubular	tubular	JJ
cord-023168-cd7adns8	848	8	necrosis	necrosis	NN
cord-023168-cd7adns8	848	9	and	and	CC
cord-023168-cd7adns8	848	10	tubular	tubular	JJ
cord-023168-cd7adns8	848	11	obstruction	obstruction	NN
cord-023168-cd7adns8	848	12	by	by	IN
cord-023168-cd7adns8	848	13	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	848	14	casts	cast	NNS
cord-023168-cd7adns8	848	15	can	can	MD
cord-023168-cd7adns8	848	16	develop	develop	VB
cord-023168-cd7adns8	848	17	as	as	IN
cord-023168-cd7adns8	848	18	a	a	DT
cord-023168-cd7adns8	848	19	complication	complication	NN
cord-023168-cd7adns8	848	20	of	of	IN
cord-023168-cd7adns8	848	21	haemolysis	haemolysis	NN
cord-023168-cd7adns8	848	22	in	in	IN
cord-023168-cd7adns8	848	23	G6PD	G6PD	NNP
cord-023168-cd7adns8	848	24	deficiency	deficiency	NN
cord-023168-cd7adns8	848	25	.	.	.
cord-023168-cd7adns8	849	1	This	this	DT
cord-023168-cd7adns8	849	2	occurs	occur	VBZ
cord-023168-cd7adns8	849	3	more	more	RBR
cord-023168-cd7adns8	849	4	often	often	RB
cord-023168-cd7adns8	849	5	in	in	IN
cord-023168-cd7adns8	849	6	adults	adult	NNS
cord-023168-cd7adns8	849	7	than	than	IN
cord-023168-cd7adns8	849	8	children	child	NNS
cord-023168-cd7adns8	849	9	and	and	CC
cord-023168-cd7adns8	849	10	may	may	MD
cord-023168-cd7adns8	849	11	require	require	VB
cord-023168-cd7adns8	849	12	haemodialysis	haemodialysis	NNP
cord-023168-cd7adns8	849	13	.	.	.
cord-023168-cd7adns8	850	1	This	this	DT
cord-023168-cd7adns8	850	2	occurs	occur	VBZ
cord-023168-cd7adns8	850	3	predominantly	predominantly	RB
cord-023168-cd7adns8	850	4	in	in	IN
cord-023168-cd7adns8	850	5	boys	boy	NNS
cord-023168-cd7adns8	850	6	aged	age	VBN
cord-023168-cd7adns8	850	7	1	1	CD
cord-023168-cd7adns8	850	8	-	-	SYM
cord-023168-cd7adns8	850	9	5	5	CD
cord-023168-cd7adns8	850	10	years	year	NNS
cord-023168-cd7adns8	850	11	in	in	IN
cord-023168-cd7adns8	850	12	Mediterranean	mediterranean	JJ
cord-023168-cd7adns8	850	13	countries	country	NNS
cord-023168-cd7adns8	850	14	,	,	,
cord-023168-cd7adns8	850	15	but	but	CC
cord-023168-cd7adns8	850	16	it	-PRON-	PRP
cord-023168-cd7adns8	850	17	has	have	VBZ
cord-023168-cd7adns8	850	18	also	also	RB
cord-023168-cd7adns8	850	19	been	be	VBN
cord-023168-cd7adns8	850	20	observed	observe	VBN
cord-023168-cd7adns8	850	21	in	in	IN
cord-023168-cd7adns8	850	22	the	the	DT
cord-023168-cd7adns8	850	23	Middle	Middle	NNP
cord-023168-cd7adns8	850	24	East	East	NNP
cord-023168-cd7adns8	850	25	,	,	,
cord-023168-cd7adns8	850	26	Asia	Asia	NNP
cord-023168-cd7adns8	850	27	and	and	CC
cord-023168-cd7adns8	850	28	North	North	NNP
cord-023168-cd7adns8	850	29	Africa	Africa	NNP
cord-023168-cd7adns8	850	30	.	.	.
cord-023168-cd7adns8	851	1	Both	both	DT
cord-023168-cd7adns8	851	2	intravascular	intravascular	JJ
cord-023168-cd7adns8	851	3	and	and	CC
cord-023168-cd7adns8	851	4	extravascular	extravascular	NNP
cord-023168-cd7adns8	851	5	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	851	6	,	,	,
cord-023168-cd7adns8	851	7	occasionally	occasionally	RB
cord-023168-cd7adns8	851	8	severe	severe	JJ
cord-023168-cd7adns8	851	9	enough	enough	RB
cord-023168-cd7adns8	851	10	to	to	TO
cord-023168-cd7adns8	851	11	cause	cause	VB
cord-023168-cd7adns8	851	12	renal	renal	JJ
cord-023168-cd7adns8	851	13	impairment	impairment	NN
cord-023168-cd7adns8	851	14	,	,	,
cord-023168-cd7adns8	851	15	can	can	MD
cord-023168-cd7adns8	851	16	occur	occur	VB
cord-023168-cd7adns8	851	17	after	after	IN
cord-023168-cd7adns8	851	18	eating	eat	VBG
cord-023168-cd7adns8	851	19	fresh	fresh	JJ
cord-023168-cd7adns8	851	20	or	or	CC
cord-023168-cd7adns8	851	21	cooked	cooked	JJ
cord-023168-cd7adns8	851	22	fava	fava	NN
cord-023168-cd7adns8	851	23	beans	bean	NNS
cord-023168-cd7adns8	851	24	,	,	,
cord-023168-cd7adns8	851	25	and	and	CC
cord-023168-cd7adns8	851	26	favism	favism	NN
cord-023168-cd7adns8	851	27	has	have	VBZ
cord-023168-cd7adns8	851	28	been	be	VBN
cord-023168-cd7adns8	851	29	reported	report	VBN
cord-023168-cd7adns8	851	30	in	in	IN
cord-023168-cd7adns8	851	31	breastfed	breastfed	JJ
cord-023168-cd7adns8	851	32	babies	baby	NNS
cord-023168-cd7adns8	851	33	of	of	IN
cord-023168-cd7adns8	851	34	mothers	mother	NNS
cord-023168-cd7adns8	851	35	who	who	WP
cord-023168-cd7adns8	851	36	have	have	VBP
cord-023168-cd7adns8	851	37	eaten	eat	VBN
cord-023168-cd7adns8	851	38	fava	fava	NN
cord-023168-cd7adns8	851	39	beans	bean	NNS
cord-023168-cd7adns8	851	40	.	.	.
cord-023168-cd7adns8	852	1	179	179	CD
cord-023168-cd7adns8	852	2	Divicine	Divicine	NNP
cord-023168-cd7adns8	852	3	and	and	CC
cord-023168-cd7adns8	852	4	isouramil	isouramil	RB
cord-023168-cd7adns8	852	5	have	have	VBP
cord-023168-cd7adns8	852	6	been	be	VBN
cord-023168-cd7adns8	852	7	implicated	implicate	VBN
cord-023168-cd7adns8	852	8	as	as	IN
cord-023168-cd7adns8	852	9	the	the	DT
cord-023168-cd7adns8	852	10	toxic	toxic	JJ
cord-023168-cd7adns8	852	11	components	component	NNS
cord-023168-cd7adns8	852	12	of	of	IN
cord-023168-cd7adns8	852	13	fava	fava	NN
cord-023168-cd7adns8	852	14	beans	bean	NNS
cord-023168-cd7adns8	852	15	.	.	.
cord-023168-cd7adns8	853	1	188	188	CD
cord-023168-cd7adns8	853	2	Neonatal	neonatal	JJ
cord-023168-cd7adns8	853	3	Jaundice	jaundice	NN
cord-023168-cd7adns8	854	1	This	this	DT
cord-023168-cd7adns8	854	2	occurs	occur	VBZ
cord-023168-cd7adns8	854	3	in	in	IN
cord-023168-cd7adns8	854	4	one	one	CD
cord-023168-cd7adns8	854	5	-	-	HYPH
cord-023168-cd7adns8	854	6	third	third	NN
cord-023168-cd7adns8	854	7	of	of	IN
cord-023168-cd7adns8	854	8	male	male	JJ
cord-023168-cd7adns8	854	9	babies	baby	NNS
cord-023168-cd7adns8	854	10	in	in	IN
cord-023168-cd7adns8	854	11	areas	area	NNS
cord-023168-cd7adns8	854	12	where	where	WRB
cord-023168-cd7adns8	854	13	G6PD	G6PD	NNP
cord-023168-cd7adns8	854	14	deficiency	deficiency	NN
cord-023168-cd7adns8	854	15	is	be	VBZ
cord-023168-cd7adns8	854	16	common	common	JJ
cord-023168-cd7adns8	854	17	and	and	CC
cord-023168-cd7adns8	854	18	is	be	VBZ
cord-023168-cd7adns8	854	19	likely	likely	JJ
cord-023168-cd7adns8	854	20	due	due	IN
cord-023168-cd7adns8	854	21	to	to	IN
cord-023168-cd7adns8	854	22	G6PD	G6PD	NNP
cord-023168-cd7adns8	854	23	deficiency	deficiency	NN
cord-023168-cd7adns8	854	24	.	.	.
cord-023168-cd7adns8	855	1	179	179	CD
cord-023168-cd7adns8	856	1	It	-PRON-	PRP
cord-023168-cd7adns8	856	2	presents	present	VBZ
cord-023168-cd7adns8	856	3	1	1	CD
cord-023168-cd7adns8	856	4	-	-	SYM
cord-023168-cd7adns8	856	5	4	4	CD
cord-023168-cd7adns8	856	6	days	day	NNS
cord-023168-cd7adns8	856	7	after	after	IN
cord-023168-cd7adns8	856	8	birth	birth	NN
cord-023168-cd7adns8	856	9	and	and	CC
cord-023168-cd7adns8	856	10	can	can	MD
cord-023168-cd7adns8	856	11	lead	lead	VB
cord-023168-cd7adns8	856	12	to	to	IN
cord-023168-cd7adns8	856	13	kernicterus	kernicterus	NNP
cord-023168-cd7adns8	856	14	.	.	.
cord-023168-cd7adns8	857	1	189	189	CD
cord-023168-cd7adns8	857	2	,	,	,
cord-023168-cd7adns8	857	3	190	190	CD
cord-023168-cd7adns8	857	4	Maternal	maternal	JJ
cord-023168-cd7adns8	857	5	exposure	exposure	NN
cord-023168-cd7adns8	857	6	to	to	IN
cord-023168-cd7adns8	857	7	oxidant	oxidant	JJ
cord-023168-cd7adns8	857	8	drugs	drug	NNS
cord-023168-cd7adns8	857	9	,	,	,
cord-023168-cd7adns8	857	10	and	and	CC
cord-023168-cd7adns8	857	11	even	even	RB
cord-023168-cd7adns8	857	12	naphthalenecamphor	naphthalenecamphor	NN
cord-023168-cd7adns8	857	13	mothballs	mothball	NNS
cord-023168-cd7adns8	857	14	,	,	,
cord-023168-cd7adns8	857	15	can	can	MD
cord-023168-cd7adns8	857	16	precipitate	precipitate	VB
cord-023168-cd7adns8	857	17	haemolysis	haemolysis	NN
cord-023168-cd7adns8	857	18	in	in	IN
cord-023168-cd7adns8	857	19	affected	affected	JJ
cord-023168-cd7adns8	857	20	babies	baby	NNS
cord-023168-cd7adns8	857	21	.	.	.
cord-023168-cd7adns8	858	1	Breast	breast	NN
cord-023168-cd7adns8	858	2	-	-	HYPH
cord-023168-cd7adns8	858	3	feeding	feed	VBG
cord-023168-cd7adns8	858	4	mothers	mother	NNS
cord-023168-cd7adns8	858	5	should	should	MD
cord-023168-cd7adns8	858	6	therefore	therefore	RB
cord-023168-cd7adns8	858	7	be	be	VB
cord-023168-cd7adns8	858	8	warned	warn	VBN
cord-023168-cd7adns8	858	9	to	to	TO
cord-023168-cd7adns8	858	10	avoid	avoid	VB
cord-023168-cd7adns8	858	11	offending	offend	VBG
cord-023168-cd7adns8	858	12	drugs	drug	NNS
cord-023168-cd7adns8	858	13	,	,	,
cord-023168-cd7adns8	858	14	umbilical	umbilical	JJ
cord-023168-cd7adns8	858	15	potions	potion	NNS
cord-023168-cd7adns8	858	16	containing	contain	VBG
cord-023168-cd7adns8	858	17	fava	fava	NN
cord-023168-cd7adns8	858	18	,	,	,
cord-023168-cd7adns8	858	19	triple	triple	JJ
cord-023168-cd7adns8	858	20	dye	dye	NN
cord-023168-cd7adns8	858	21	or	or	CC
cord-023168-cd7adns8	858	22	menthol	menthol	NN
cord-023168-cd7adns8	858	23	,	,	,
cord-023168-cd7adns8	858	24	and	and	CC
cord-023168-cd7adns8	858	25	should	should	MD
cord-023168-cd7adns8	858	26	not	not	RB
cord-023168-cd7adns8	858	27	apply	apply	VB
cord-023168-cd7adns8	858	28	henna	henna	NN
cord-023168-cd7adns8	858	29	to	to	IN
cord-023168-cd7adns8	858	30	the	the	DT
cord-023168-cd7adns8	858	31	skin	skin	NN
cord-023168-cd7adns8	858	32	or	or	CC
cord-023168-cd7adns8	858	33	use	use	VB
cord-023168-cd7adns8	858	34	clothes	clothe	NNS
cord-023168-cd7adns8	858	35	that	that	WDT
cord-023168-cd7adns8	858	36	have	have	VBP
cord-023168-cd7adns8	858	37	been	be	VBN
cord-023168-cd7adns8	858	38	stored	store	VBN
cord-023168-cd7adns8	858	39	in	in	IN
cord-023168-cd7adns8	858	40	naphthalene	naphthalene	NN
cord-023168-cd7adns8	858	41	.	.	.
cord-023168-cd7adns8	859	1	190	190	CD
cord-023168-cd7adns8	859	2	Premature	premature	JJ
cord-023168-cd7adns8	859	3	infants	infant	NNS
cord-023168-cd7adns8	859	4	and	and	CC
cord-023168-cd7adns8	859	5	babies	baby	NNS
cord-023168-cd7adns8	859	6	who	who	WP
cord-023168-cd7adns8	859	7	have	have	VBP
cord-023168-cd7adns8	859	8	co	co	VBN
cord-023168-cd7adns8	859	9	-	-	VBN
cord-023168-cd7adns8	859	10	inherited	inherit	VBD
cord-023168-cd7adns8	859	11	the	the	DT
cord-023168-cd7adns8	859	12	mutation	mutation	NN
cord-023168-cd7adns8	859	13	for	for	IN
cord-023168-cd7adns8	859	14	Gilbert	Gilbert	NNP
cord-023168-cd7adns8	859	15	's	's	POS
cord-023168-cd7adns8	859	16	syndrome	syndrome	NN
cord-023168-cd7adns8	859	17	are	be	VBP
cord-023168-cd7adns8	859	18	at	at	IN
cord-023168-cd7adns8	859	19	particular	particular	JJ
cord-023168-cd7adns8	859	20	risk	risk	NN
cord-023168-cd7adns8	859	21	.	.	.
cord-023168-cd7adns8	860	1	Phototherapy	Phototherapy	NNP
cord-023168-cd7adns8	860	2	and	and	CC
cord-023168-cd7adns8	860	3	exchange	exchange	NN
cord-023168-cd7adns8	860	4	transfusion	transfusion	NN
cord-023168-cd7adns8	860	5	therapy	therapy	NN
cord-023168-cd7adns8	860	6	may	may	MD
cord-023168-cd7adns8	860	7	be	be	VB
cord-023168-cd7adns8	860	8	required	require	VBN
cord-023168-cd7adns8	860	9	to	to	TO
cord-023168-cd7adns8	860	10	reduce	reduce	VB
cord-023168-cd7adns8	860	11	the	the	DT
cord-023168-cd7adns8	860	12	level	level	NN
cord-023168-cd7adns8	860	13	of	of	IN
cord-023168-cd7adns8	860	14	unconjugated	unconjugated	JJ
cord-023168-cd7adns8	860	15	bilirubin	bilirubin	NN
cord-023168-cd7adns8	860	16	.	.	.
cord-023168-cd7adns8	861	1	The	the	DT
cord-023168-cd7adns8	861	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	861	3	may	may	MD
cord-023168-cd7adns8	861	4	be	be	VB
cord-023168-cd7adns8	861	5	easily	easily	RB
cord-023168-cd7adns8	861	6	missed	miss	VBN
cord-023168-cd7adns8	861	7	so	so	RB
cord-023168-cd7adns8	861	8	assessment	assessment	NN
cord-023168-cd7adns8	861	9	of	of	IN
cord-023168-cd7adns8	861	10	G6PD	G6PD	NNP
cord-023168-cd7adns8	861	11	status	status	NN
cord-023168-cd7adns8	861	12	should	should	MD
cord-023168-cd7adns8	861	13	be	be	VB
cord-023168-cd7adns8	861	14	undertaken	undertake	VBN
cord-023168-cd7adns8	861	15	for	for	IN
cord-023168-cd7adns8	861	16	any	any	DT
cord-023168-cd7adns8	861	17	jaundiced	jaundiced	JJ
cord-023168-cd7adns8	861	18	infant	infant	NN
cord-023168-cd7adns8	861	19	whose	whose	WP$
cord-023168-cd7adns8	861	20	family	family	NN
cord-023168-cd7adns8	861	21	history	history	NN
cord-023168-cd7adns8	861	22	or	or	CC
cord-023168-cd7adns8	861	23	ethnic	ethnic	JJ
cord-023168-cd7adns8	861	24	or	or	CC
cord-023168-cd7adns8	861	25	geographic	geographic	JJ
cord-023168-cd7adns8	861	26	origin	origin	NN
cord-023168-cd7adns8	861	27	suggest	suggest	VBP
cord-023168-cd7adns8	861	28	the	the	DT
cord-023168-cd7adns8	861	29	likelihood	likelihood	NN
cord-023168-cd7adns8	861	30	of	of	IN
cord-023168-cd7adns8	861	31	G6PD	G6PD	NNP
cord-023168-cd7adns8	861	32	deficiency	deficiency	NN
cord-023168-cd7adns8	861	33	,	,	,
cord-023168-cd7adns8	861	34	and	and	CC
cord-023168-cd7adns8	861	35	in	in	IN
cord-023168-cd7adns8	861	36	infants	infant	NNS
cord-023168-cd7adns8	861	37	who	who	WP
cord-023168-cd7adns8	861	38	respond	respond	VBP
cord-023168-cd7adns8	861	39	poorly	poorly	RB
cord-023168-cd7adns8	861	40	to	to	IN
cord-023168-cd7adns8	861	41	phototherapy	phototherapy	NN
cord-023168-cd7adns8	861	42	.	.	.
cord-023168-cd7adns8	862	1	191	191	CD
cord-023168-cd7adns8	863	1	This	this	DT
cord-023168-cd7adns8	863	2	is	be	VBZ
cord-023168-cd7adns8	863	3	an	an	DT
cord-023168-cd7adns8	863	4	unusual	unusual	JJ
cord-023168-cd7adns8	863	5	manifestation	manifestation	NN
cord-023168-cd7adns8	863	6	of	of	IN
cord-023168-cd7adns8	863	7	G6PD	G6PD	NNP
cord-023168-cd7adns8	863	8	deficiency	deficiency	NN
cord-023168-cd7adns8	863	9	and	and	CC
cord-023168-cd7adns8	863	10	usually	usually	RB
cord-023168-cd7adns8	863	11	presents	present	VBZ
cord-023168-cd7adns8	863	12	in	in	IN
cord-023168-cd7adns8	863	13	childhood	childhood	NN
cord-023168-cd7adns8	863	14	.	.	.
cord-023168-cd7adns8	864	1	179	179	CD
cord-023168-cd7adns8	864	2	,	,	,
cord-023168-cd7adns8	864	3	184	184	CD
cord-023168-cd7adns8	864	4	There	there	EX
cord-023168-cd7adns8	864	5	may	may	MD
cord-023168-cd7adns8	864	6	be	be	VB
cord-023168-cd7adns8	864	7	a	a	DT
cord-023168-cd7adns8	864	8	history	history	NN
cord-023168-cd7adns8	864	9	of	of	IN
cord-023168-cd7adns8	864	10	severe	severe	JJ
cord-023168-cd7adns8	864	11	neonatal	neonatal	JJ
cord-023168-cd7adns8	864	12	jaundice	jaundice	NN
cord-023168-cd7adns8	864	13	,	,	,
cord-023168-cd7adns8	864	14	episodic	episodic	JJ
cord-023168-cd7adns8	864	15	or	or	CC
cord-023168-cd7adns8	864	16	worsening	worsen	VBG
cord-023168-cd7adns8	864	17	anaemia	anaemia	NN
cord-023168-cd7adns8	864	18	which	which	WDT
cord-023168-cd7adns8	864	19	requires	require	VBZ
cord-023168-cd7adns8	864	20	blood	blood	NN
cord-023168-cd7adns8	864	21	transfusions	transfusion	NNS
cord-023168-cd7adns8	864	22	,	,	,
cord-023168-cd7adns8	864	23	and	and	CC
cord-023168-cd7adns8	864	24	complications	complication	NNS
cord-023168-cd7adns8	864	25	from	from	IN
cord-023168-cd7adns8	864	26	gallstones	gallstone	NNS
cord-023168-cd7adns8	864	27	.	.	.
cord-023168-cd7adns8	865	1	Although	although	IN
cord-023168-cd7adns8	865	2	these	these	DT
cord-023168-cd7adns8	865	3	individuals	individual	NNS
cord-023168-cd7adns8	865	4	usually	usually	RB
cord-023168-cd7adns8	865	5	have	have	VBP
cord-023168-cd7adns8	865	6	a	a	DT
cord-023168-cd7adns8	865	7	well	well	RB
cord-023168-cd7adns8	865	8	-	-	HYPH
cord-023168-cd7adns8	865	9	compensated	compensate	VBN
cord-023168-cd7adns8	865	10	anaemia	anaemia	NN
cord-023168-cd7adns8	865	11	,	,	,
cord-023168-cd7adns8	865	12	and	and	CC
cord-023168-cd7adns8	865	13	require	require	VB
cord-023168-cd7adns8	865	14	transfusions	transfusion	NNS
cord-023168-cd7adns8	865	15	only	only	RB
cord-023168-cd7adns8	865	16	for	for	IN
cord-023168-cd7adns8	865	17	exacerbations	exacerbation	NNS
cord-023168-cd7adns8	865	18	,	,	,
cord-023168-cd7adns8	865	19	rarely	rarely	RB
cord-023168-cd7adns8	865	20	some	some	DT
cord-023168-cd7adns8	865	21	may	may	MD
cord-023168-cd7adns8	865	22	become	become	VB
cord-023168-cd7adns8	865	23	transfusion	transfusion	NN
cord-023168-cd7adns8	865	24	-	-	HYPH
cord-023168-cd7adns8	865	25	dependent	dependent	JJ
cord-023168-cd7adns8	865	26	.	.	.
cord-023168-cd7adns8	866	1	Antioxidants	antioxidant	NNS
cord-023168-cd7adns8	866	2	such	such	JJ
cord-023168-cd7adns8	866	3	as	as	IN
cord-023168-cd7adns8	866	4	vitamin	vitamin	NN
cord-023168-cd7adns8	866	5	E	e	NN
cord-023168-cd7adns8	866	6	and	and	CC
cord-023168-cd7adns8	866	7	selenium	selenium	NN
cord-023168-cd7adns8	866	8	may	may	MD
cord-023168-cd7adns8	866	9	be	be	VB
cord-023168-cd7adns8	866	10	of	of	IN
cord-023168-cd7adns8	866	11	benefit	benefit	NN
cord-023168-cd7adns8	866	12	in	in	IN
cord-023168-cd7adns8	866	13	some	some	DT
cord-023168-cd7adns8	866	14	cases	case	NNS
cord-023168-cd7adns8	866	15	.	.	.
cord-023168-cd7adns8	867	1	The	the	DT
cord-023168-cd7adns8	867	2	haemolysis	haemolysis	NN
cord-023168-cd7adns8	867	3	does	do	VBZ
cord-023168-cd7adns8	867	4	not	not	RB
cord-023168-cd7adns8	867	5	resolve	resolve	VB
cord-023168-cd7adns8	867	6	following	follow	VBG
cord-023168-cd7adns8	867	7	splenectomy	splenectomy	NN
cord-023168-cd7adns8	867	8	.	.	.
cord-023168-cd7adns8	868	1	Folic	folic	JJ
cord-023168-cd7adns8	868	2	acid	acid	JJ
cord-023168-cd7adns8	868	3	supplementation	supplementation	NN
cord-023168-cd7adns8	868	4	is	be	VBZ
cord-023168-cd7adns8	868	5	necessary	necessary	JJ
cord-023168-cd7adns8	868	6	to	to	TO
cord-023168-cd7adns8	868	7	support	support	VB
cord-023168-cd7adns8	868	8	the	the	DT
cord-023168-cd7adns8	868	9	increased	increase	VBN
cord-023168-cd7adns8	868	10	compensatory	compensatory	JJ
cord-023168-cd7adns8	868	11	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	868	12	.	.	.
cord-023168-cd7adns8	869	1	The	the	DT
cord-023168-cd7adns8	869	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	869	3	of	of	IN
cord-023168-cd7adns8	869	4	G6PD	G6PD	NNP
cord-023168-cd7adns8	869	5	deficiency	deficiency	NN
cord-023168-cd7adns8	869	6	is	be	VBZ
cord-023168-cd7adns8	869	7	usually	usually	RB
cord-023168-cd7adns8	869	8	suspected	suspect	VBN
cord-023168-cd7adns8	869	9	when	when	WRB
cord-023168-cd7adns8	869	10	neonatal	neonatal	JJ
cord-023168-cd7adns8	869	11	jaundice	jaundice	NN
cord-023168-cd7adns8	869	12	occurs	occur	VBZ
cord-023168-cd7adns8	869	13	in	in	IN
cord-023168-cd7adns8	869	14	an	an	DT
cord-023168-cd7adns8	869	15	area	area	NN
cord-023168-cd7adns8	869	16	where	where	WRB
cord-023168-cd7adns8	869	17	G6PD	G6PD	NNP
cord-023168-cd7adns8	869	18	deficiency	deficiency	NN
cord-023168-cd7adns8	869	19	is	be	VBZ
cord-023168-cd7adns8	869	20	Drugs	drug	NNS
cord-023168-cd7adns8	869	21	Which	which	WDT
cord-023168-cd7adns8	869	22	May	May	MD
cord-023168-cd7adns8	869	23	Cause	cause	VB
cord-023168-cd7adns8	869	24	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	869	25	in	in	IN
cord-023168-cd7adns8	869	26	G6PD	G6PD	NNP
cord-023168-cd7adns8	869	27	-	-	HYPH
cord-023168-cd7adns8	869	28	Deficient	Deficient	NNP
cord-023168-cd7adns8	869	29	Individuals	Individuals	NNPS
cord-023168-cd7adns8	869	30	common	common	JJ
cord-023168-cd7adns8	869	31	or	or	CC
cord-023168-cd7adns8	869	32	when	when	WRB
cord-023168-cd7adns8	869	33	an	an	DT
cord-023168-cd7adns8	869	34	episode	episode	NN
cord-023168-cd7adns8	869	35	of	of	IN
cord-023168-cd7adns8	869	36	non	non	JJ
cord-023168-cd7adns8	869	37	-	-	JJ
cord-023168-cd7adns8	869	38	immune	immune	JJ
cord-023168-cd7adns8	869	39	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	869	40	anaemia	anaemia	NN
cord-023168-cd7adns8	869	41	occurs	occur	VBZ
cord-023168-cd7adns8	869	42	in	in	IN
cord-023168-cd7adns8	869	43	association	association	NN
cord-023168-cd7adns8	869	44	with	with	IN
cord-023168-cd7adns8	869	45	an	an	DT
cord-023168-cd7adns8	869	46	infection	infection	NN
cord-023168-cd7adns8	869	47	or	or	CC
cord-023168-cd7adns8	869	48	drug	drug	NN
cord-023168-cd7adns8	869	49	.	.	.
cord-023168-cd7adns8	870	1	The	the	DT
cord-023168-cd7adns8	870	2	appearance	appearance	NN
cord-023168-cd7adns8	870	3	of	of	IN
cord-023168-cd7adns8	870	4	the	the	DT
cord-023168-cd7adns8	870	5	red	red	JJ
cord-023168-cd7adns8	870	6	cells	cell	NNS
cord-023168-cd7adns8	870	7	on	on	IN
cord-023168-cd7adns8	870	8	the	the	DT
cord-023168-cd7adns8	870	9	blood	blood	NN
cord-023168-cd7adns8	870	10	film	film	NN
cord-023168-cd7adns8	870	11	is	be	VBZ
cord-023168-cd7adns8	870	12	characteristic	characteristic	JJ
cord-023168-cd7adns8	870	13	because	because	IN
cord-023168-cd7adns8	870	14	denatured	denatured	JJ
cord-023168-cd7adns8	870	15	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	870	16	concentrates	concentrate	VBZ
cord-023168-cd7adns8	870	17	in	in	IN
cord-023168-cd7adns8	870	18	one	one	CD
cord-023168-cd7adns8	870	19	area	area	NN
cord-023168-cd7adns8	870	20	within	within	IN
cord-023168-cd7adns8	870	21	the	the	DT
cord-023168-cd7adns8	870	22	cell	cell	NN
cord-023168-cd7adns8	870	23	creating	create	VBG
cord-023168-cd7adns8	870	24	'	'	``
cord-023168-cd7adns8	870	25	helmet	helmet	NN
cord-023168-cd7adns8	870	26	'	'	''
cord-023168-cd7adns8	870	27	or	or	CC
cord-023168-cd7adns8	870	28	'	'	``
cord-023168-cd7adns8	870	29	bite	bite	NN
cord-023168-cd7adns8	870	30	'	'	''
cord-023168-cd7adns8	870	31	cells	cell	NNS
cord-023168-cd7adns8	870	32	.	.	.
cord-023168-cd7adns8	871	1	192	192	CD
cord-023168-cd7adns8	871	2	Denatured	denatured	JJ
cord-023168-cd7adns8	871	3	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	871	4	precipitates	precipitate	VBZ
cord-023168-cd7adns8	871	5	in	in	IN
cord-023168-cd7adns8	871	6	peripheral	peripheral	JJ
cord-023168-cd7adns8	871	7	red	red	JJ
cord-023168-cd7adns8	871	8	blood	blood	NN
cord-023168-cd7adns8	871	9	cells	cell	NNS
cord-023168-cd7adns8	871	10	as	as	IN
cord-023168-cd7adns8	871	11	Heinz	Heinz	NNP
cord-023168-cd7adns8	871	12	bodies	body	NNS
cord-023168-cd7adns8	871	13	which	which	WDT
cord-023168-cd7adns8	871	14	can	can	MD
cord-023168-cd7adns8	871	15	be	be	VB
cord-023168-cd7adns8	871	16	detected	detect	VBN
cord-023168-cd7adns8	871	17	by	by	IN
cord-023168-cd7adns8	871	18	staining	stain	VBG
cord-023168-cd7adns8	871	19	with	with	IN
cord-023168-cd7adns8	871	20	methyl	methyl	NN
cord-023168-cd7adns8	871	21	violet	violet	NN
cord-023168-cd7adns8	871	22	.	.	.
cord-023168-cd7adns8	872	1	Definitive	definitive	JJ
cord-023168-cd7adns8	872	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	872	3	of	of	IN
cord-023168-cd7adns8	872	4	G6PD	G6PD	NNP
cord-023168-cd7adns8	872	5	deficiency	deficiency	NN
cord-023168-cd7adns8	872	6	is	be	VBZ
cord-023168-cd7adns8	872	7	by	by	IN
cord-023168-cd7adns8	872	8	quantitative	quantitative	JJ
cord-023168-cd7adns8	872	9	spectrophotometric	spectrophotometric	JJ
cord-023168-cd7adns8	872	10	analysis	analysis	NN
cord-023168-cd7adns8	872	11	of	of	IN
cord-023168-cd7adns8	872	12	the	the	DT
cord-023168-cd7adns8	872	13	rate	rate	NN
cord-023168-cd7adns8	872	14	of	of	IN
cord-023168-cd7adns8	872	15	NADPH	NADPH	NNP
cord-023168-cd7adns8	872	16	production	production	NN
cord-023168-cd7adns8	872	17	.	.	.
cord-023168-cd7adns8	873	1	Point	point	NN
cord-023168-cd7adns8	873	2	of	of	IN
cord-023168-cd7adns8	873	3	care	care	NN
cord-023168-cd7adns8	873	4	tests	test	NNS
cord-023168-cd7adns8	873	5	for	for	IN
cord-023168-cd7adns8	873	6	G6PD	G6PD	NNP
cord-023168-cd7adns8	873	7	deficiency	deficiency	NN
cord-023168-cd7adns8	873	8	are	be	VBP
cord-023168-cd7adns8	873	9	being	be	VBG
cord-023168-cd7adns8	873	10	developed	develop	VBN
cord-023168-cd7adns8	873	11	but	but	CC
cord-023168-cd7adns8	873	12	have	have	VBP
cord-023168-cd7adns8	873	13	not	not	RB
cord-023168-cd7adns8	873	14	yet	yet	RB
cord-023168-cd7adns8	873	15	been	be	VBN
cord-023168-cd7adns8	873	16	validated	validate	VBN
cord-023168-cd7adns8	873	17	for	for	IN
cord-023168-cd7adns8	873	18	routine	routine	JJ
cord-023168-cd7adns8	873	19	use	use	NN
cord-023168-cd7adns8	873	20	.	.	.
cord-023168-cd7adns8	874	1	Measuring	measure	VBG
cord-023168-cd7adns8	874	2	enzyme	enzyme	NN
cord-023168-cd7adns8	874	3	activity	activity	NN
cord-023168-cd7adns8	874	4	during	during	IN
cord-023168-cd7adns8	874	5	an	an	DT
cord-023168-cd7adns8	874	6	episode	episode	NN
cord-023168-cd7adns8	874	7	of	of	IN
cord-023168-cd7adns8	874	8	acute	acute	JJ
cord-023168-cd7adns8	874	9	haemolysis	haemolysis	NN
cord-023168-cd7adns8	874	10	is	be	VBZ
cord-023168-cd7adns8	874	11	not	not	RB
cord-023168-cd7adns8	874	12	helpful	helpful	JJ
cord-023168-cd7adns8	874	13	since	since	IN
cord-023168-cd7adns8	874	14	reticulocytosis	reticulocytosis	NNP
cord-023168-cd7adns8	874	15	,	,	,
cord-023168-cd7adns8	874	16	which	which	WDT
cord-023168-cd7adns8	874	17	is	be	VBZ
cord-023168-cd7adns8	874	18	a	a	DT
cord-023168-cd7adns8	874	19	feature	feature	NN
cord-023168-cd7adns8	874	20	of	of	IN
cord-023168-cd7adns8	874	21	acute	acute	JJ
cord-023168-cd7adns8	874	22	haemolysis	haemolysis	NN
cord-023168-cd7adns8	874	23	,	,	,
cord-023168-cd7adns8	874	24	produces	produce	VBZ
cord-023168-cd7adns8	874	25	a	a	DT
cord-023168-cd7adns8	874	26	false	false	JJ
cord-023168-cd7adns8	874	27	-	-	HYPH
cord-023168-cd7adns8	874	28	negative	negative	JJ
cord-023168-cd7adns8	874	29	result	result	NN
cord-023168-cd7adns8	874	30	because	because	IN
cord-023168-cd7adns8	874	31	of	of	IN
cord-023168-cd7adns8	874	32	the	the	DT
cord-023168-cd7adns8	874	33	high	high	JJ
cord-023168-cd7adns8	874	34	enzyme	enzyme	NN
cord-023168-cd7adns8	874	35	levels	level	NNS
cord-023168-cd7adns8	874	36	in	in	IN
cord-023168-cd7adns8	874	37	younger	young	JJR
cord-023168-cd7adns8	874	38	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	874	39	.	.	.
cord-023168-cd7adns8	875	1	179	179	CD
cord-023168-cd7adns8	875	2	,	,	,
cord-023168-cd7adns8	875	3	186	186	CD
cord-023168-cd7adns8	875	4	MANAGEMENT	management	NN
cord-023168-cd7adns8	876	1	The	the	DT
cord-023168-cd7adns8	876	2	most	most	RBS
cord-023168-cd7adns8	876	3	effective	effective	JJ
cord-023168-cd7adns8	876	4	management	management	NN
cord-023168-cd7adns8	876	5	strategy	strategy	NN
cord-023168-cd7adns8	876	6	for	for	IN
cord-023168-cd7adns8	876	7	G6PD	G6PD	NNP
cord-023168-cd7adns8	876	8	deficiency	deficiency	NN
cord-023168-cd7adns8	876	9	is	be	VBZ
cord-023168-cd7adns8	876	10	to	to	TO
cord-023168-cd7adns8	876	11	prevent	prevent	VB
cord-023168-cd7adns8	876	12	haemolysis	haemolysis	NN
cord-023168-cd7adns8	876	13	by	by	IN
cord-023168-cd7adns8	876	14	avoiding	avoid	VBG
cord-023168-cd7adns8	876	15	triggering	trigger	VBG
cord-023168-cd7adns8	876	16	agents	agent	NNS
cord-023168-cd7adns8	876	17	like	like	IN
cord-023168-cd7adns8	876	18	infections	infection	NNS
cord-023168-cd7adns8	876	19	,	,	,
cord-023168-cd7adns8	876	20	drugs	drug	NNS
cord-023168-cd7adns8	876	21	and	and	CC
cord-023168-cd7adns8	876	22	fava	fava	NN
cord-023168-cd7adns8	876	23	beans	bean	NNS
cord-023168-cd7adns8	876	24	.	.	.
cord-023168-cd7adns8	877	1	For	for	IN
cord-023168-cd7adns8	877	2	the	the	DT
cord-023168-cd7adns8	877	3	milder	mild	JJR
cord-023168-cd7adns8	877	4	variants	variant	NNS
cord-023168-cd7adns8	877	5	(	(	-LRB-
cord-023168-cd7adns8	877	6	e.g.	e.g.	NNP
cord-023168-cd7adns8	877	7	Class	Class	NNP
cord-023168-cd7adns8	877	8	III	III	NNP
cord-023168-cd7adns8	877	9	and	and	CC
cord-023168-cd7adns8	877	10	IV	IV	NNP
cord-023168-cd7adns8	877	11	)	)	-RRB-
cord-023168-cd7adns8	877	12	,	,	,
cord-023168-cd7adns8	877	13	drugs	drug	NNS
cord-023168-cd7adns8	877	14	known	know	VBN
cord-023168-cd7adns8	877	15	to	to	TO
cord-023168-cd7adns8	877	16	trigger	trigger	VB
cord-023168-cd7adns8	877	17	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	877	18	may	may	MD
cord-023168-cd7adns8	877	19	be	be	VB
cord-023168-cd7adns8	877	20	given	give	VBN
cord-023168-cd7adns8	877	21	to	to	IN
cord-023168-cd7adns8	877	22	individuals	individual	NNS
cord-023168-cd7adns8	877	23	with	with	IN
cord-023168-cd7adns8	877	24	G6PD	G6PD	NNP
cord-023168-cd7adns8	877	25	deficiency	deficiency	NN
cord-023168-cd7adns8	877	26	if	if	IN
cord-023168-cd7adns8	877	27	the	the	DT
cord-023168-cd7adns8	877	28	benefits	benefit	NNS
cord-023168-cd7adns8	877	29	outweigh	outweigh	VBP
cord-023168-cd7adns8	877	30	the	the	DT
cord-023168-cd7adns8	877	31	risks	risk	NNS
cord-023168-cd7adns8	877	32	and	and	CC
cord-023168-cd7adns8	877	33	the	the	DT
cord-023168-cd7adns8	877	34	blood	blood	NN
cord-023168-cd7adns8	877	35	count	count	NN
cord-023168-cd7adns8	877	36	is	be	VBZ
cord-023168-cd7adns8	877	37	closely	closely	RB
cord-023168-cd7adns8	877	38	monitored	monitor	VBN
cord-023168-cd7adns8	877	39	(	(	-LRB-
cord-023168-cd7adns8	877	40	e.g.	e.g.	IN
cord-023168-cd7adns8	877	41	use	use	NN
cord-023168-cd7adns8	877	42	of	of	IN
cord-023168-cd7adns8	877	43	low	low	JJ
cord-023168-cd7adns8	877	44	-	-	HYPH
cord-023168-cd7adns8	877	45	dose	dose	NN
cord-023168-cd7adns8	877	46	primaquine	primaquine	NN
cord-023168-cd7adns8	877	47	for	for	IN
cord-023168-cd7adns8	877	48	individuals	individual	NNS
cord-023168-cd7adns8	877	49	with	with	IN
cord-023168-cd7adns8	877	50	G6PD	G6PD	NNP
cord-023168-cd7adns8	877	51	Avariant	Avariant	NNP
cord-023168-cd7adns8	877	52	)	)	-RRB-
cord-023168-cd7adns8	877	53	.	.	.
cord-023168-cd7adns8	878	1	Screening	screening	NN
cord-023168-cd7adns8	878	2	programmes	programme	NNS
cord-023168-cd7adns8	878	3	have	have	VBP
cord-023168-cd7adns8	878	4	been	be	VBN
cord-023168-cd7adns8	878	5	established	establish	VBN
cord-023168-cd7adns8	878	6	in	in	IN
cord-023168-cd7adns8	878	7	some	some	DT
cord-023168-cd7adns8	878	8	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	878	9	and	and	CC
cord-023168-cd7adns8	878	10	other	other	JJ
cord-023168-cd7adns8	878	11	populations	population	NNS
cord-023168-cd7adns8	878	12	where	where	WRB
cord-023168-cd7adns8	878	13	G6PD	G6PD	NNP
cord-023168-cd7adns8	878	14	deficiency	deficiency	NN
cord-023168-cd7adns8	878	15	is	be	VBZ
cord-023168-cd7adns8	878	16	prevalent	prevalent	JJ
cord-023168-cd7adns8	878	17	.	.	.
cord-023168-cd7adns8	879	1	193	193	CD
cord-023168-cd7adns8	879	2	Haematological	Haematological	NNP
cord-023168-cd7adns8	879	3	Complications	Complications	NNPS
cord-023168-cd7adns8	879	4	of	of	IN
cord-023168-cd7adns8	879	5	Malaria	Malaria	NNP
cord-023168-cd7adns8	879	6	(	(	-LRB-
cord-023168-cd7adns8	879	7	see	see	VB
cord-023168-cd7adns8	879	8	Chapter	chapter	NN
cord-023168-cd7adns8	879	9	43	43	CD
cord-023168-cd7adns8	879	10	)	)	-RRB-
cord-023168-cd7adns8	880	1	The	the	DT
cord-023168-cd7adns8	880	2	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	880	3	of	of	IN
cord-023168-cd7adns8	880	4	anaemia	anaemia	NN
cord-023168-cd7adns8	880	5	in	in	IN
cord-023168-cd7adns8	880	6	malaria	malaria	NN
cord-023168-cd7adns8	880	7	is	be	VBZ
cord-023168-cd7adns8	880	8	multi	multi	JJ
cord-023168-cd7adns8	880	9	-	-	JJ
cord-023168-cd7adns8	880	10	factorial	factorial	JJ
cord-023168-cd7adns8	880	11	and	and	CC
cord-023168-cd7adns8	880	12	influenced	influence	VBN
cord-023168-cd7adns8	880	13	by	by	IN
cord-023168-cd7adns8	880	14	the	the	DT
cord-023168-cd7adns8	880	15	age	age	NN
cord-023168-cd7adns8	880	16	of	of	IN
cord-023168-cd7adns8	880	17	the	the	DT
cord-023168-cd7adns8	880	18	individual	individual	NN
cord-023168-cd7adns8	880	19	and	and	CC
cord-023168-cd7adns8	880	20	their	-PRON-	PRP$
cord-023168-cd7adns8	880	21	antimalarial	antimalarial	JJ
cord-023168-cd7adns8	880	22	immune	immune	JJ
cord-023168-cd7adns8	880	23	status	status	NN
cord-023168-cd7adns8	880	24	.	.	.
cord-023168-cd7adns8	881	1	Anaemia	anaemia	NN
cord-023168-cd7adns8	881	2	mechanisms	mechanism	NNS
cord-023168-cd7adns8	881	3	in	in	IN
cord-023168-cd7adns8	881	4	malaria	malaria	NN
cord-023168-cd7adns8	881	5	involve	involve	NN
cord-023168-cd7adns8	881	6	:	:	:
cord-023168-cd7adns8	882	1	•	•	NNP
cord-023168-cd7adns8	883	1	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	883	2	with	with	IN
cord-023168-cd7adns8	883	3	increased	increase	VBN
cord-023168-cd7adns8	883	4	red	red	JJ
cord-023168-cd7adns8	883	5	cell	cell	NN
cord-023168-cd7adns8	883	6	destruction	destruction	NN
cord-023168-cd7adns8	883	7	of	of	IN
cord-023168-cd7adns8	883	8	both	both	CC
cord-023168-cd7adns8	883	9	infected	infect	VBN
cord-023168-cd7adns8	883	10	and	and	CC
cord-023168-cd7adns8	883	11	bystander	bystander	NN
cord-023168-cd7adns8	883	12	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	884	1	•	•	NNP
cord-023168-cd7adns8	885	1	Dyserythropoiesis	Dyserythropoiesis	NNP
cord-023168-cd7adns8	886	1	•	•	NNP
cord-023168-cd7adns8	887	1	Hypersplenism	hypersplenism	NN
cord-023168-cd7adns8	888	1	•	•	NNP
cord-023168-cd7adns8	889	1	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	890	1	•	•	NNP
cord-023168-cd7adns8	890	2	Co	co	NN
cord-023168-cd7adns8	890	3	-	-	JJ
cord-023168-cd7adns8	890	4	existent	existent	JJ
cord-023168-cd7adns8	890	5	conditions	condition	NNS
cord-023168-cd7adns8	890	6	which	which	WDT
cord-023168-cd7adns8	890	7	can	can	MD
cord-023168-cd7adns8	890	8	cause	cause	VB
cord-023168-cd7adns8	890	9	anaemia	anaemia	NN
cord-023168-cd7adns8	890	10	.	.	.
cord-023168-cd7adns8	891	1	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	891	2	is	be	VBZ
cord-023168-cd7adns8	891	3	more	more	RBR
cord-023168-cd7adns8	891	4	common	common	JJ
cord-023168-cd7adns8	891	5	in	in	IN
cord-023168-cd7adns8	891	6	non	non	JJ
cord-023168-cd7adns8	891	7	-	-	JJ
cord-023168-cd7adns8	891	8	immune	immune	JJ
cord-023168-cd7adns8	891	9	individuals	individual	NNS
cord-023168-cd7adns8	891	10	with	with	IN
cord-023168-cd7adns8	891	11	acute	acute	JJ
cord-023168-cd7adns8	891	12	malaria	malaria	NN
cord-023168-cd7adns8	891	13	,	,	,
cord-023168-cd7adns8	891	14	whereas	whereas	IN
cord-023168-cd7adns8	891	15	dyserythropoiesis	dyserythropoiesis	NN
cord-023168-cd7adns8	891	16	is	be	VBZ
cord-023168-cd7adns8	891	17	the	the	DT
cord-023168-cd7adns8	891	18	predominant	predominant	JJ
cord-023168-cd7adns8	891	19	mechanism	mechanism	NN
cord-023168-cd7adns8	891	20	for	for	IN
cord-023168-cd7adns8	891	21	anaemia	anaemia	NN
cord-023168-cd7adns8	891	22	in	in	IN
cord-023168-cd7adns8	891	23	recurrent	recurrent	JJ
cord-023168-cd7adns8	891	24	falciparum	falciparum	NN
cord-023168-cd7adns8	891	25	malaria	malaria	NN
cord-023168-cd7adns8	891	26	.	.	.
cord-023168-cd7adns8	892	1	207	207	CD
cord-023168-cd7adns8	892	2	,	,	,
cord-023168-cd7adns8	892	3	194	194	CD
cord-023168-cd7adns8	892	4	Haemolysis	Haemolysis	NNP
cord-023168-cd7adns8	892	5	is	be	VBZ
cord-023168-cd7adns8	892	6	the	the	DT
cord-023168-cd7adns8	892	7	result	result	NN
cord-023168-cd7adns8	892	8	of	of	IN
cord-023168-cd7adns8	892	9	red	red	JJ
cord-023168-cd7adns8	892	10	cell	cell	NN
cord-023168-cd7adns8	892	11	phagocytosis	phagocytosis	NN
cord-023168-cd7adns8	892	12	by	by	IN
cord-023168-cd7adns8	892	13	the	the	DT
cord-023168-cd7adns8	892	14	reticuloendothelial	reticuloendothelial	JJ
cord-023168-cd7adns8	892	15	system	system	NN
cord-023168-cd7adns8	892	16	and	and	CC
cord-023168-cd7adns8	892	17	is	be	VBZ
cord-023168-cd7adns8	892	18	triggered	trigger	VBN
cord-023168-cd7adns8	892	19	by	by	IN
cord-023168-cd7adns8	892	20	damage	damage	NN
cord-023168-cd7adns8	892	21	to	to	IN
cord-023168-cd7adns8	892	22	the	the	DT
cord-023168-cd7adns8	892	23	red	red	JJ
cord-023168-cd7adns8	892	24	cell	cell	NN
cord-023168-cd7adns8	892	25	membranes	membrane	NNS
cord-023168-cd7adns8	892	26	and	and	CC
cord-023168-cd7adns8	892	27	exposure	exposure	NN
cord-023168-cd7adns8	892	28	of	of	IN
cord-023168-cd7adns8	892	29	abnormal	abnormal	JJ
cord-023168-cd7adns8	892	30	surface	surface	NN
cord-023168-cd7adns8	892	31	antigens	antigen	NNS
cord-023168-cd7adns8	892	32	on	on	IN
cord-023168-cd7adns8	892	33	their	-PRON-	PRP$
cord-023168-cd7adns8	892	34	surface	surface	NN
cord-023168-cd7adns8	892	35	.	.	.
cord-023168-cd7adns8	893	1	[	[	-LRB-
cord-023168-cd7adns8	893	2	195	195	CD
cord-023168-cd7adns8	893	3	]	]	-RRB-
cord-023168-cd7adns8	893	4	[	[	-LRB-
cord-023168-cd7adns8	893	5	196	196	CD
cord-023168-cd7adns8	893	6	]	]	-RRB-
cord-023168-cd7adns8	893	7	[	[	-LRB-
cord-023168-cd7adns8	893	8	197	197	CD
cord-023168-cd7adns8	893	9	]	]	-RRB-
cord-023168-cd7adns8	894	1	[	[	-LRB-
cord-023168-cd7adns8	894	2	198	198	CD
cord-023168-cd7adns8	894	3	]	]	-RRB-
cord-023168-cd7adns8	895	1	Ten	ten	CD
cord-023168-cd7adns8	895	2	uninfected	uninfected	JJ
cord-023168-cd7adns8	895	3	red	red	JJ
cord-023168-cd7adns8	895	4	cells	cell	NNS
cord-023168-cd7adns8	895	5	are	be	VBP
cord-023168-cd7adns8	895	6	removed	remove	VBN
cord-023168-cd7adns8	895	7	from	from	IN
cord-023168-cd7adns8	895	8	the	the	DT
cord-023168-cd7adns8	895	9	circulation	circulation	NN
cord-023168-cd7adns8	895	10	for	for	IN
cord-023168-cd7adns8	895	11	each	each	DT
cord-023168-cd7adns8	895	12	infected	infect	VBN
cord-023168-cd7adns8	895	13	red	red	JJ
cord-023168-cd7adns8	895	14	cell	cell	NN
cord-023168-cd7adns8	895	15	destroyed	destroy	VBN
cord-023168-cd7adns8	895	16	,	,	,
cord-023168-cd7adns8	895	17	199	199	CD
cord-023168-cd7adns8	895	18	possibly	possibly	RB
cord-023168-cd7adns8	895	19	related	relate	VBN
cord-023168-cd7adns8	895	20	to	to	IN
cord-023168-cd7adns8	895	21	loss	loss	NN
cord-023168-cd7adns8	895	22	of	of	IN
cord-023168-cd7adns8	895	23	red	red	JJ
cord-023168-cd7adns8	895	24	cell	cell	NN
cord-023168-cd7adns8	895	25	complement	complement	NN
cord-023168-cd7adns8	895	26	regulatory	regulatory	JJ
cord-023168-cd7adns8	895	27	proteins	protein	NNS
cord-023168-cd7adns8	895	28	and	and	CC
cord-023168-cd7adns8	895	29	increased	increase	VBN
cord-023168-cd7adns8	895	30	levels	level	NNS
cord-023168-cd7adns8	895	31	of	of	IN
cord-023168-cd7adns8	895	32	circulating	circulate	VBG
cord-023168-cd7adns8	895	33	immune	immune	JJ
cord-023168-cd7adns8	895	34	complexes	complex	NNS
cord-023168-cd7adns8	895	35	.	.	.
cord-023168-cd7adns8	896	1	200	200	CD
cord-023168-cd7adns8	897	1	This	this	DT
cord-023168-cd7adns8	897	2	may	may	MD
cord-023168-cd7adns8	897	3	partly	partly	RB
cord-023168-cd7adns8	897	4	explain	explain	VB
cord-023168-cd7adns8	897	5	the	the	DT
cord-023168-cd7adns8	897	6	persistent	persistent	JJ
cord-023168-cd7adns8	897	7	or	or	CC
cord-023168-cd7adns8	897	8	worsening	worsen	VBG
cord-023168-cd7adns8	897	9	anaemia	anaemia	NN
cord-023168-cd7adns8	897	10	following	follow	VBG
cord-023168-cd7adns8	897	11	parasite	parasite	NN
cord-023168-cd7adns8	897	12	clearance	clearance	NN
cord-023168-cd7adns8	897	13	and	and	CC
cord-023168-cd7adns8	897	14	the	the	DT
cord-023168-cd7adns8	897	15	poor	poor	JJ
cord-023168-cd7adns8	897	16	correlation	correlation	NN
cord-023168-cd7adns8	897	17	between	between	IN
cord-023168-cd7adns8	897	18	parasitaemia	parasitaemia	NN
cord-023168-cd7adns8	897	19	and	and	CC
cord-023168-cd7adns8	897	20	the	the	DT
cord-023168-cd7adns8	897	21	severity	severity	NN
cord-023168-cd7adns8	897	22	of	of	IN
cord-023168-cd7adns8	897	23	anaemia	anaemia	NN
cord-023168-cd7adns8	897	24	noted	note	VBN
cord-023168-cd7adns8	897	25	in	in	IN
cord-023168-cd7adns8	897	26	some	some	DT
cord-023168-cd7adns8	897	27	studies	study	NNS
cord-023168-cd7adns8	897	28	.	.	.
cord-023168-cd7adns8	898	1	207	207	CD
cord-023168-cd7adns8	899	1	An	an	DT
cord-023168-cd7adns8	899	2	increased	increase	VBN
cord-023168-cd7adns8	899	3	incidence	incidence	NN
cord-023168-cd7adns8	899	4	of	of	IN
cord-023168-cd7adns8	899	5	anaemia	anaemia	NN
cord-023168-cd7adns8	899	6	has	have	VBZ
cord-023168-cd7adns8	899	7	been	be	VBN
cord-023168-cd7adns8	899	8	noted	note	VBN
cord-023168-cd7adns8	899	9	in	in	IN
cord-023168-cd7adns8	899	10	malaria	malaria	NN
cord-023168-cd7adns8	899	11	vaccine	vaccine	NN
cord-023168-cd7adns8	899	12	trials	trial	NNS
cord-023168-cd7adns8	899	13	possibly	possibly	RB
cord-023168-cd7adns8	899	14	due	due	JJ
cord-023168-cd7adns8	899	15	to	to	IN
cord-023168-cd7adns8	899	16	enhanced	enhanced	JJ
cord-023168-cd7adns8	899	17	clearance	clearance	NN
cord-023168-cd7adns8	899	18	of	of	IN
cord-023168-cd7adns8	899	19	uninfected	uninfected	JJ
cord-023168-cd7adns8	899	20	red	red	JJ
cord-023168-cd7adns8	899	21	blood	blood	NN
cord-023168-cd7adns8	899	22	cells	cell	NNS
cord-023168-cd7adns8	899	23	.	.	.
cord-023168-cd7adns8	900	1	201	201	CD
cord-023168-cd7adns8	900	2	Decreased	decrease	VBD
cord-023168-cd7adns8	900	3	erythropoeisis	erythropoeisis	NN
cord-023168-cd7adns8	900	4	with	with	IN
cord-023168-cd7adns8	900	5	abnormalities	abnormality	NNS
cord-023168-cd7adns8	900	6	in	in	IN
cord-023168-cd7adns8	900	7	red	red	JJ
cord-023168-cd7adns8	900	8	cell	cell	NN
cord-023168-cd7adns8	900	9	precursors	precursor	NNS
cord-023168-cd7adns8	900	10	and	and	CC
cord-023168-cd7adns8	900	11	reticulocytopenia	reticulocytopenia	NNP
cord-023168-cd7adns8	900	12	is	be	VBZ
cord-023168-cd7adns8	900	13	found	find	VBN
cord-023168-cd7adns8	900	14	consistently	consistently	RB
cord-023168-cd7adns8	900	15	on	on	IN
cord-023168-cd7adns8	900	16	examination	examination	NN
cord-023168-cd7adns8	900	17	of	of	IN
cord-023168-cd7adns8	900	18	bone	bone	NN
cord-023168-cd7adns8	900	19	marrow	marrow	NN
cord-023168-cd7adns8	900	20	from	from	IN
cord-023168-cd7adns8	900	21	malaria	malaria	NN
cord-023168-cd7adns8	900	22	-	-	HYPH
cord-023168-cd7adns8	900	23	infected	infect	VBN
cord-023168-cd7adns8	900	24	patients	patient	NNS
cord-023168-cd7adns8	900	25	.	.	.
cord-023168-cd7adns8	901	1	202	202	CD
cord-023168-cd7adns8	902	1	The	the	DT
cord-023168-cd7adns8	902	2	decreased	decrease	VBN
cord-023168-cd7adns8	902	3	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	902	4	is	be	VBZ
cord-023168-cd7adns8	902	5	due	due	JJ
cord-023168-cd7adns8	902	6	to	to	IN
cord-023168-cd7adns8	902	7	many	many	JJ
cord-023168-cd7adns8	902	8	factors	factor	NNS
cord-023168-cd7adns8	902	9	including	include	VBG
cord-023168-cd7adns8	902	10	low	low	JJ
cord-023168-cd7adns8	902	11	levels	level	NNS
cord-023168-cd7adns8	902	12	of	of	IN
cord-023168-cd7adns8	902	13	TNF	TNF	NNP
cord-023168-cd7adns8	902	14	-	-	HYPH
cord-023168-cd7adns8	902	15	α	α	NNP
cord-023168-cd7adns8	902	16	,	,	,
cord-023168-cd7adns8	902	17	high	high	JJ
cord-023168-cd7adns8	902	18	levels	level	NNS
cord-023168-cd7adns8	902	19	of	of	IN
cord-023168-cd7adns8	902	20	interleukin-10	interleukin-10	NN
cord-023168-cd7adns8	902	21	,	,	,
cord-023168-cd7adns8	902	22	abnormalities	abnormality	NNS
cord-023168-cd7adns8	902	23	of	of	IN
cord-023168-cd7adns8	902	24	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	902	25	,	,	,
cord-023168-cd7adns8	902	26	a	a	DT
cord-023168-cd7adns8	902	27	decrease	decrease	NN
cord-023168-cd7adns8	902	28	in	in	IN
cord-023168-cd7adns8	902	29	burst	burst	NN
cord-023168-cd7adns8	902	30	colony	colony	NN
cord-023168-cd7adns8	902	31	forming	form	VBG
cord-023168-cd7adns8	902	32	units	unit	NNS
cord-023168-cd7adns8	902	33	,	,	,
cord-023168-cd7adns8	902	34	cytokine	cytokine	NN
cord-023168-cd7adns8	902	35	-	-	HYPH
cord-023168-cd7adns8	902	36	induced	induce	VBN
cord-023168-cd7adns8	902	37	suppression	suppression	NN
cord-023168-cd7adns8	902	38	of	of	IN
cord-023168-cd7adns8	902	39	red	red	JJ
cord-023168-cd7adns8	902	40	cell	cell	NN
cord-023168-cd7adns8	902	41	production	production	NN
cord-023168-cd7adns8	902	42	and	and	CC
cord-023168-cd7adns8	902	43	the	the	DT
cord-023168-cd7adns8	902	44	inhibitory	inhibitory	JJ
cord-023168-cd7adns8	902	45	effect	effect	NN
cord-023168-cd7adns8	902	46	of	of	IN
cord-023168-cd7adns8	902	47	the	the	DT
cord-023168-cd7adns8	902	48	malarial	malarial	JJ
cord-023168-cd7adns8	902	49	pigment	pigment	NN
cord-023168-cd7adns8	902	50	haemozoin	haemozoin	NN
cord-023168-cd7adns8	902	51	.	.	.
cord-023168-cd7adns8	903	1	[	[	-LRB-
cord-023168-cd7adns8	903	2	203	203	CD
cord-023168-cd7adns8	903	3	]	]	-RRB-
cord-023168-cd7adns8	903	4	[	[	-LRB-
cord-023168-cd7adns8	903	5	204	204	CD
cord-023168-cd7adns8	903	6	]	]	-RRB-
cord-023168-cd7adns8	904	1	[	[	-LRB-
cord-023168-cd7adns8	904	2	205	205	CD
cord-023168-cd7adns8	904	3	]	]	-RRB-
cord-023168-cd7adns8	904	4	[	[	-LRB-
cord-023168-cd7adns8	904	5	206	206	CD
cord-023168-cd7adns8	904	6	]	]	-RRB-
cord-023168-cd7adns8	905	1	Epidemiology	Epidemiology	NNP
cord-023168-cd7adns8	905	2	Malaria	Malaria	NNP
cord-023168-cd7adns8	905	3	-	-	HYPH
cord-023168-cd7adns8	905	4	related	relate	VBN
cord-023168-cd7adns8	905	5	anaemia	anaemia	NN
cord-023168-cd7adns8	905	6	is	be	VBZ
cord-023168-cd7adns8	905	7	most	most	RBS
cord-023168-cd7adns8	905	8	commonly	commonly	RB
cord-023168-cd7adns8	905	9	seen	see	VBN
cord-023168-cd7adns8	905	10	in	in	IN
cord-023168-cd7adns8	905	11	children	child	NNS
cord-023168-cd7adns8	905	12	and	and	CC
cord-023168-cd7adns8	905	13	pregnant	pregnant	JJ
cord-023168-cd7adns8	905	14	women	woman	NNS
cord-023168-cd7adns8	905	15	.	.	.
cord-023168-cd7adns8	906	1	The	the	DT
cord-023168-cd7adns8	906	2	prevalence	prevalence	NN
cord-023168-cd7adns8	906	3	of	of	IN
cord-023168-cd7adns8	906	4	malarial	malarial	JJ
cord-023168-cd7adns8	906	5	anaemia	anaemia	NN
cord-023168-cd7adns8	906	6	in	in	IN
cord-023168-cd7adns8	906	7	sub	sub	JJ
cord-023168-cd7adns8	906	8	-	-	JJ
cord-023168-cd7adns8	906	9	Saharan	Saharan	NNP
cord-023168-cd7adns8	906	10	Africa	Africa	NNP
cord-023168-cd7adns8	906	11	in	in	IN
cord-023168-cd7adns8	906	12	children	child	NNS
cord-023168-cd7adns8	906	13	is	be	VBZ
cord-023168-cd7adns8	906	14	30	30	CD
cord-023168-cd7adns8	906	15	-	-	SYM
cord-023168-cd7adns8	906	16	90	90	CD
cord-023168-cd7adns8	906	17	%	%	NN
cord-023168-cd7adns8	906	18	and	and	CC
cord-023168-cd7adns8	906	19	in	in	IN
cord-023168-cd7adns8	906	20	pregnant	pregnant	JJ
cord-023168-cd7adns8	906	21	women	woman	NNS
cord-023168-cd7adns8	906	22	it	-PRON-	PRP
cord-023168-cd7adns8	906	23	is	be	VBZ
cord-023168-cd7adns8	906	24	60	60	CD
cord-023168-cd7adns8	906	25	-	-	SYM
cord-023168-cd7adns8	906	26	80	80	CD
cord-023168-cd7adns8	906	27	%	%	NN
cord-023168-cd7adns8	906	28	.	.	.
cord-023168-cd7adns8	907	1	207	207	CD
cord-023168-cd7adns8	908	1	The	the	DT
cord-023168-cd7adns8	908	2	highest	high	JJS
cord-023168-cd7adns8	908	3	prevalence	prevalence	NN
cord-023168-cd7adns8	908	4	is	be	VBZ
cord-023168-cd7adns8	908	5	in	in	IN
cord-023168-cd7adns8	908	6	infants	infant	NNS
cord-023168-cd7adns8	908	7	and	and	CC
cord-023168-cd7adns8	908	8	children	child	NNS
cord-023168-cd7adns8	908	9	less	less	JJR
cord-023168-cd7adns8	908	10	than	than	IN
cord-023168-cd7adns8	908	11	3	3	CD
cord-023168-cd7adns8	908	12	years	year	NNS
cord-023168-cd7adns8	908	13	of	of	IN
cord-023168-cd7adns8	908	14	age	age	NN
cord-023168-cd7adns8	908	15	.	.	.
cord-023168-cd7adns8	909	1	Infants	infant	NNS
cord-023168-cd7adns8	909	2	may	may	MD
cord-023168-cd7adns8	909	3	acquire	acquire	VB
cord-023168-cd7adns8	909	4	malaria	malaria	NN
cord-023168-cd7adns8	909	5	through	through	IN
cord-023168-cd7adns8	909	6	the	the	DT
cord-023168-cd7adns8	909	7	placenta	placenta	NN
cord-023168-cd7adns8	909	8	.	.	.
cord-023168-cd7adns8	910	1	208	208	CD
cord-023168-cd7adns8	910	2	,	,	,
cord-023168-cd7adns8	910	3	209	209	CD
cord-023168-cd7adns8	910	4	Individuals	individual	NNS
cord-023168-cd7adns8	910	5	living	live	VBG
cord-023168-cd7adns8	910	6	in	in	IN
cord-023168-cd7adns8	910	7	malarious	malarious	JJ
cord-023168-cd7adns8	910	8	areas	area	NNS
cord-023168-cd7adns8	910	9	may	may	MD
cord-023168-cd7adns8	910	10	have	have	VB
cord-023168-cd7adns8	910	11	multiple	multiple	JJ
cord-023168-cd7adns8	910	12	reasons	reason	NNS
cord-023168-cd7adns8	910	13	for	for	IN
cord-023168-cd7adns8	910	14	anaemia	anaemia	NN
cord-023168-cd7adns8	910	15	such	such	JJ
cord-023168-cd7adns8	910	16	as	as	IN
cord-023168-cd7adns8	910	17	bacteraemia	bacteraemia	NN
cord-023168-cd7adns8	910	18	,	,	,
cord-023168-cd7adns8	910	19	hookworm	hookworm	NN
cord-023168-cd7adns8	910	20	infections	infection	NNS
cord-023168-cd7adns8	910	21	and	and	CC
cord-023168-cd7adns8	910	22	vitamin	vitamin	NN
cord-023168-cd7adns8	910	23	A	a	DT
cord-023168-cd7adns8	910	24	deficiency	deficiency	NN
cord-023168-cd7adns8	910	25	208	208	CD
cord-023168-cd7adns8	910	26	making	make	VBG
cord-023168-cd7adns8	910	27	it	-PRON-	PRP
cord-023168-cd7adns8	910	28	difficult	difficult	JJ
cord-023168-cd7adns8	910	29	to	to	TO
cord-023168-cd7adns8	910	30	assign	assign	VB
cord-023168-cd7adns8	910	31	anaemia	anaemia	NN
cord-023168-cd7adns8	910	32	solely	solely	RB
cord-023168-cd7adns8	910	33	to	to	IN
cord-023168-cd7adns8	910	34	malaria	malaria	NN
cord-023168-cd7adns8	910	35	.	.	.
cord-023168-cd7adns8	911	1	However	however	RB
cord-023168-cd7adns8	911	2	,	,	,
cord-023168-cd7adns8	911	3	animal	animal	NN
cord-023168-cd7adns8	911	4	studies	study	NNS
cord-023168-cd7adns8	911	5	and	and	CC
cord-023168-cd7adns8	911	6	the	the	DT
cord-023168-cd7adns8	911	7	fact	fact	NN
cord-023168-cd7adns8	911	8	that	that	IN
cord-023168-cd7adns8	911	9	anaemia	anaemia	NN
cord-023168-cd7adns8	911	10	improves	improve	VBZ
cord-023168-cd7adns8	911	11	with	with	IN
cord-023168-cd7adns8	911	12	anti	anti	JJ
cord-023168-cd7adns8	911	13	-	-	JJ
cord-023168-cd7adns8	911	14	malarial	malarial	JJ
cord-023168-cd7adns8	911	15	treatment	treatment	NN
cord-023168-cd7adns8	911	16	suggest	suggest	VBP
cord-023168-cd7adns8	911	17	a	a	DT
cord-023168-cd7adns8	911	18	direct	direct	JJ
cord-023168-cd7adns8	911	19	relationship	relationship	NN
cord-023168-cd7adns8	911	20	between	between	IN
cord-023168-cd7adns8	911	21	malaria	malaria	NN
cord-023168-cd7adns8	911	22	infection	infection	NN
cord-023168-cd7adns8	911	23	and	and	CC
cord-023168-cd7adns8	911	24	anaemia	anaemia	NN
cord-023168-cd7adns8	911	25	.	.	.
cord-023168-cd7adns8	912	1	210	210	CD
cord-023168-cd7adns8	912	2	,	,	,
cord-023168-cd7adns8	912	3	211	211	CD
cord-023168-cd7adns8	913	1	For	for	IN
cord-023168-cd7adns8	913	2	example	example	NN
cord-023168-cd7adns8	913	3	,	,	,
cord-023168-cd7adns8	913	4	in	in	IN
cord-023168-cd7adns8	913	5	Tanzanian	tanzanian	JJ
cord-023168-cd7adns8	913	6	children	child	NNS
cord-023168-cd7adns8	913	7	about	about	RB
cord-023168-cd7adns8	913	8	60	60	CD
cord-023168-cd7adns8	913	9	%	%	NN
cord-023168-cd7adns8	913	10	of	of	IN
cord-023168-cd7adns8	913	11	anaemic	anaemic	JJ
cord-023168-cd7adns8	913	12	episodes	episode	NNS
cord-023168-cd7adns8	913	13	were	be	VBD
cord-023168-cd7adns8	913	14	thought	think	VBN
cord-023168-cd7adns8	913	15	to	to	TO
cord-023168-cd7adns8	913	16	be	be	VB
cord-023168-cd7adns8	913	17	caused	cause	VBN
cord-023168-cd7adns8	913	18	by	by	IN
cord-023168-cd7adns8	913	19	malaria	malaria	NN
cord-023168-cd7adns8	913	20	.	.	.
cord-023168-cd7adns8	914	1	212	212	CD
cord-023168-cd7adns8	914	2	WHO	who	WP
cord-023168-cd7adns8	914	3	defines	define	VBZ
cord-023168-cd7adns8	914	4	severe	severe	JJ
cord-023168-cd7adns8	914	5	anaemia	anaemia	NN
cord-023168-cd7adns8	914	6	attributable	attributable	JJ
cord-023168-cd7adns8	914	7	to	to	IN
cord-023168-cd7adns8	914	8	malaria	malaria	NN
cord-023168-cd7adns8	914	9	as	as	IN
cord-023168-cd7adns8	914	10	:	:	:
cord-023168-cd7adns8	915	1	(	(	-LRB-
cord-023168-cd7adns8	915	2	i	i	NN
cord-023168-cd7adns8	915	3	)	)	-RRB-
cord-023168-cd7adns8	915	4	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	915	5	concentration	concentration	NN
cord-023168-cd7adns8	916	1	<	<	XX
cord-023168-cd7adns8	916	2	50	50	CD
cord-023168-cd7adns8	916	3	g	g	NN
cord-023168-cd7adns8	916	4	/	/	SYM
cord-023168-cd7adns8	916	5	L	L	NNP
cord-023168-cd7adns8	916	6	or	or	CC
cord-023168-cd7adns8	916	7	haematocrit	haematocrit	NNP
cord-023168-cd7adns8	916	8	<	<	XX
cord-023168-cd7adns8	916	9	15	15	CD
cord-023168-cd7adns8	916	10	%	%	NN
cord-023168-cd7adns8	916	11	;	;	.
cord-023168-cd7adns8	917	1	(	(	-LRB-
cord-023168-cd7adns8	917	2	ii	ii	LS
cord-023168-cd7adns8	917	3	)	)	-RRB-
cord-023168-cd7adns8	917	4	parasitaemia	parasitaemia	NNP
cord-023168-cd7adns8	917	5	with	with	IN
cord-023168-cd7adns8	917	6	>	>	XX
cord-023168-cd7adns8	918	1	10	10	CD
cord-023168-cd7adns8	918	2	000	000	CD
cord-023168-cd7adns8	918	3	parasites/µL	parasites/µl	XX
cord-023168-cd7adns8	918	4	of	of	IN
cord-023168-cd7adns8	918	5	blood	blood	NN
cord-023168-cd7adns8	918	6	and	and	CC
cord-023168-cd7adns8	918	7	(	(	-LRB-
cord-023168-cd7adns8	918	8	iii	iii	NN
cord-023168-cd7adns8	918	9	)	)	-RRB-
cord-023168-cd7adns8	918	10	normocytic	normocytic	JJ
cord-023168-cd7adns8	918	11	blood	blood	NN
cord-023168-cd7adns8	918	12	film	film	NN
cord-023168-cd7adns8	918	13	(	(	-LRB-
cord-023168-cd7adns8	919	1	to	to	TO
cord-023168-cd7adns8	919	2	exclude	exclude	VB
cord-023168-cd7adns8	919	3	other	other	JJ
cord-023168-cd7adns8	919	4	common	common	JJ
cord-023168-cd7adns8	919	5	causes	cause	NNS
cord-023168-cd7adns8	919	6	of	of	IN
cord-023168-cd7adns8	919	7	anaemia	anaemia	NN
cord-023168-cd7adns8	919	8	)	)	-RRB-
cord-023168-cd7adns8	919	9	.	.	.
cord-023168-cd7adns8	920	1	213	213	CD
cord-023168-cd7adns8	921	1	However	however	RB
cord-023168-cd7adns8	921	2	,	,	,
cord-023168-cd7adns8	921	3	aspects	aspect	NNS
cord-023168-cd7adns8	921	4	of	of	IN
cord-023168-cd7adns8	921	5	this	this	DT
cord-023168-cd7adns8	921	6	definition	definition	NN
cord-023168-cd7adns8	921	7	have	have	VBP
cord-023168-cd7adns8	921	8	been	be	VBN
cord-023168-cd7adns8	921	9	criticized	criticize	VBN
cord-023168-cd7adns8	921	10	because	because	IN
cord-023168-cd7adns8	921	11	blood	blood	NN
cord-023168-cd7adns8	921	12	films	film	NNS
cord-023168-cd7adns8	921	13	are	be	VBP
cord-023168-cd7adns8	921	14	not	not	RB
cord-023168-cd7adns8	921	15	examined	examine	VBN
cord-023168-cd7adns8	921	16	routinely	routinely	RB
cord-023168-cd7adns8	921	17	and	and	CC
cord-023168-cd7adns8	921	18	parasite	parasite	JJ
cord-023168-cd7adns8	921	19	density	density	NN
cord-023168-cd7adns8	921	20	varies	vary	VBZ
cord-023168-cd7adns8	921	21	with	with	IN
cord-023168-cd7adns8	921	22	endemicity	endemicity	NN
cord-023168-cd7adns8	921	23	and	and	CC
cord-023168-cd7adns8	921	24	age	age	NN
cord-023168-cd7adns8	921	25	.	.	.
cord-023168-cd7adns8	922	1	207	207	CD
cord-023168-cd7adns8	923	1	Although	although	IN
cord-023168-cd7adns8	923	2	traditionally	traditionally	RB
cord-023168-cd7adns8	923	3	it	-PRON-	PRP
cord-023168-cd7adns8	923	4	is	be	VBZ
cord-023168-cd7adns8	923	5	P.	P.	NNP
cord-023168-cd7adns8	923	6	falciparum	falciparum	NN
cord-023168-cd7adns8	923	7	that	that	WDT
cord-023168-cd7adns8	923	8	has	have	VBZ
cord-023168-cd7adns8	923	9	been	be	VBN
cord-023168-cd7adns8	923	10	associated	associate	VBN
cord-023168-cd7adns8	923	11	with	with	IN
cord-023168-cd7adns8	923	12	the	the	DT
cord-023168-cd7adns8	923	13	most	most	RBS
cord-023168-cd7adns8	923	14	severe	severe	JJ
cord-023168-cd7adns8	923	15	malaria	malaria	NN
cord-023168-cd7adns8	923	16	-	-	HYPH
cord-023168-cd7adns8	923	17	related	relate	VBN
cord-023168-cd7adns8	923	18	anaemia	anaemia	NN
cord-023168-cd7adns8	923	19	,	,	,
cord-023168-cd7adns8	923	20	P.	p.	NN
cord-023168-cd7adns8	923	21	vivax	vivax	NN
cord-023168-cd7adns8	923	22	is	be	VBZ
cord-023168-cd7adns8	923	23	also	also	RB
cord-023168-cd7adns8	923	24	a	a	DT
cord-023168-cd7adns8	923	25	major	major	JJ
cord-023168-cd7adns8	923	26	risk	risk	NN
cord-023168-cd7adns8	923	27	factor	factor	NN
cord-023168-cd7adns8	923	28	for	for	IN
cord-023168-cd7adns8	923	29	severe	severe	JJ
cord-023168-cd7adns8	923	30	anaemia	anaemia	NN
cord-023168-cd7adns8	923	31	especially	especially	RB
cord-023168-cd7adns8	923	32	in	in	IN
cord-023168-cd7adns8	923	33	young	young	JJ
cord-023168-cd7adns8	923	34	children	child	NNS
cord-023168-cd7adns8	923	35	or	or	CC
cord-023168-cd7adns8	923	36	those	those	DT
cord-023168-cd7adns8	923	37	with	with	IN
cord-023168-cd7adns8	923	38	chronic	chronic	JJ
cord-023168-cd7adns8	923	39	and	and	CC
cord-023168-cd7adns8	923	40	recurrent	recurrent	JJ
cord-023168-cd7adns8	923	41	infections	infection	NNS
cord-023168-cd7adns8	923	42	.	.	.
cord-023168-cd7adns8	924	1	P.	p.	NN
cord-023168-cd7adns8	924	2	vivax	vivax	JJ
cord-023168-cd7adns8	924	3	anaemia	anaemia	NN
cord-023168-cd7adns8	924	4	is	be	VBZ
cord-023168-cd7adns8	924	5	associated	associate	VBN
cord-023168-cd7adns8	924	6	with	with	IN
cord-023168-cd7adns8	924	7	recurrent	recurrent	JJ
cord-023168-cd7adns8	924	8	bouts	bout	NNS
cord-023168-cd7adns8	924	9	of	of	IN
cord-023168-cd7adns8	924	10	haemolysis	haemolysis	NN
cord-023168-cd7adns8	924	11	of	of	IN
cord-023168-cd7adns8	924	12	predominantly	predominantly	RB
cord-023168-cd7adns8	924	13	uninfected	uninfected	JJ
cord-023168-cd7adns8	924	14	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	924	15	with	with	IN
cord-023168-cd7adns8	924	16	increased	increase	VBN
cord-023168-cd7adns8	924	17	fragility	fragility	NN
cord-023168-cd7adns8	924	18	.	.	.
cord-023168-cd7adns8	925	1	214	214	CD
cord-023168-cd7adns8	925	2	 	 	_SP
cord-023168-cd7adns8	925	3	Symptoms	symptom	NNS
cord-023168-cd7adns8	925	4	of	of	IN
cord-023168-cd7adns8	925	5	malarial	malarial	JJ
cord-023168-cd7adns8	925	6	anaemia	anaemia	NN
cord-023168-cd7adns8	925	7	can	can	MD
cord-023168-cd7adns8	925	8	vary	vary	VB
cord-023168-cd7adns8	925	9	from	from	IN
cord-023168-cd7adns8	925	10	negligible	negligible	JJ
cord-023168-cd7adns8	925	11	to	to	IN
cord-023168-cd7adns8	925	12	profound	profound	JJ
cord-023168-cd7adns8	925	13	depending	depending	NN
cord-023168-cd7adns8	925	14	on	on	IN
cord-023168-cd7adns8	925	15	the	the	DT
cord-023168-cd7adns8	925	16	degree	degree	NN
cord-023168-cd7adns8	925	17	of	of	IN
cord-023168-cd7adns8	925	18	anaemia	anaemia	NN
cord-023168-cd7adns8	925	19	and	and	CC
cord-023168-cd7adns8	925	20	the	the	DT
cord-023168-cd7adns8	925	21	rapidity	rapidity	NN
cord-023168-cd7adns8	925	22	of	of	IN
cord-023168-cd7adns8	925	23	onset	onset	NN
cord-023168-cd7adns8	925	24	.	.	.
cord-023168-cd7adns8	926	1	Splenomegaly	Splenomegaly	NNP
cord-023168-cd7adns8	926	2	is	be	VBZ
cord-023168-cd7adns8	926	3	a	a	DT
cord-023168-cd7adns8	926	4	common	common	JJ
cord-023168-cd7adns8	926	5	feature	feature	NN
cord-023168-cd7adns8	926	6	of	of	IN
cord-023168-cd7adns8	926	7	malarial	malarial	JJ
cord-023168-cd7adns8	926	8	anaemia	anaemia	NN
cord-023168-cd7adns8	926	9	because	because	IN
cord-023168-cd7adns8	926	10	of	of	IN
cord-023168-cd7adns8	926	11	the	the	DT
cord-023168-cd7adns8	926	12	role	role	NN
cord-023168-cd7adns8	926	13	of	of	IN
cord-023168-cd7adns8	926	14	the	the	DT
cord-023168-cd7adns8	926	15	spleen	spleen	NNS
cord-023168-cd7adns8	926	16	in	in	IN
cord-023168-cd7adns8	926	17	the	the	DT
cord-023168-cd7adns8	926	18	removal	removal	NN
cord-023168-cd7adns8	926	19	of	of	IN
cord-023168-cd7adns8	926	20	both	both	CC
cord-023168-cd7adns8	926	21	infected	infected	JJ
cord-023168-cd7adns8	926	22	and	and	CC
cord-023168-cd7adns8	926	23	uninfected	uninfected	JJ
cord-023168-cd7adns8	926	24	red	red	JJ
cord-023168-cd7adns8	926	25	cells	cell	NNS
cord-023168-cd7adns8	926	26	.	.	.
cord-023168-cd7adns8	927	1	215	215	CD
cord-023168-cd7adns8	927	2	Blackwater	Blackwater	NNP
cord-023168-cd7adns8	927	3	fever	fever	NN
cord-023168-cd7adns8	927	4	,	,	,
cord-023168-cd7adns8	927	5	characterized	characterize	VBN
cord-023168-cd7adns8	927	6	by	by	IN
cord-023168-cd7adns8	927	7	intense	intense	JJ
cord-023168-cd7adns8	927	8	intravascular	intravascular	JJ
cord-023168-cd7adns8	927	9	haemolysis	haemolysis	NN
cord-023168-cd7adns8	927	10	with	with	IN
cord-023168-cd7adns8	927	11	haemoglobinuria	haemoglobinuria	NNP
cord-023168-cd7adns8	927	12	and	and	CC
cord-023168-cd7adns8	927	13	occasionally	occasionally	RB
cord-023168-cd7adns8	927	14	renal	renal	JJ
cord-023168-cd7adns8	927	15	failure	failure	NN
cord-023168-cd7adns8	927	16	in	in	IN
cord-023168-cd7adns8	927	17	a	a	DT
cord-023168-cd7adns8	927	18	patient	patient	NN
cord-023168-cd7adns8	927	19	with	with	IN
cord-023168-cd7adns8	927	20	malaria	malaria	NN
cord-023168-cd7adns8	927	21	,	,	,
cord-023168-cd7adns8	927	22	may	may	MD
cord-023168-cd7adns8	927	23	be	be	VB
cord-023168-cd7adns8	927	24	related	relate	VBN
cord-023168-cd7adns8	927	25	to	to	IN
cord-023168-cd7adns8	927	26	underlying	underlie	VBG
cord-023168-cd7adns8	927	27	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-023168-cd7adns8	927	28	deficiency	deficiency	NN
cord-023168-cd7adns8	927	29	.	.	.
cord-023168-cd7adns8	928	1	216	216	CD
cord-023168-cd7adns8	928	2	,	,	,
cord-023168-cd7adns8	928	3	217	217	CD
cord-023168-cd7adns8	928	4	Factors	factor	NNS
cord-023168-cd7adns8	928	5	such	such	JJ
cord-023168-cd7adns8	928	6	as	as	IN
cord-023168-cd7adns8	928	7	poor	poor	JJ
cord-023168-cd7adns8	928	8	nutrition	nutrition	NN
cord-023168-cd7adns8	928	9	,	,	,
cord-023168-cd7adns8	928	10	deficiencies	deficiency	NNS
cord-023168-cd7adns8	928	11	of	of	IN
cord-023168-cd7adns8	928	12	vitamins	vitamin	NNS
cord-023168-cd7adns8	928	13	and	and	CC
cord-023168-cd7adns8	928	14	micronutrients	micronutrient	NNS
cord-023168-cd7adns8	928	15	,	,	,
cord-023168-cd7adns8	928	16	bacteraemia	bacteraemia	NN
cord-023168-cd7adns8	928	17	,	,	,
cord-023168-cd7adns8	928	18	and	and	CC
cord-023168-cd7adns8	928	19	hookworm	hookworm	NN
cord-023168-cd7adns8	928	20	or	or	CC
cord-023168-cd7adns8	928	21	HIV	HIV	NNP
cord-023168-cd7adns8	928	22	infection	infection	NN
cord-023168-cd7adns8	928	23	may	may	MD
cord-023168-cd7adns8	928	24	co	co	VB
cord-023168-cd7adns8	928	25	-	-	VB
cord-023168-cd7adns8	928	26	exist	exist	VB
cord-023168-cd7adns8	928	27	with	with	IN
cord-023168-cd7adns8	928	28	malaria	malaria	NN
cord-023168-cd7adns8	928	29	and	and	CC
cord-023168-cd7adns8	928	30	contribute	contribute	VB
cord-023168-cd7adns8	928	31	to	to	IN
cord-023168-cd7adns8	928	32	anaemia	anaemia	NN
cord-023168-cd7adns8	928	33	209	209	CD
cord-023168-cd7adns8	929	1	so	so	IN
cord-023168-cd7adns8	929	2	nonmalarial	nonmalarial	JJ
cord-023168-cd7adns8	929	3	causes	cause	NNS
cord-023168-cd7adns8	929	4	of	of	IN
cord-023168-cd7adns8	929	5	anaemia	anaemia	NN
cord-023168-cd7adns8	929	6	should	should	MD
cord-023168-cd7adns8	929	7	be	be	VB
cord-023168-cd7adns8	929	8	considered	consider	VBN
cord-023168-cd7adns8	929	9	in	in	IN
cord-023168-cd7adns8	929	10	patients	patient	NNS
cord-023168-cd7adns8	929	11	whose	whose	WP$
cord-023168-cd7adns8	929	12	anaemia	anaemia	NN
cord-023168-cd7adns8	929	13	does	do	VBZ
cord-023168-cd7adns8	929	14	not	not	RB
cord-023168-cd7adns8	929	15	respond	respond	VB
cord-023168-cd7adns8	929	16	to	to	IN
cord-023168-cd7adns8	929	17	malaria	malaria	NN
cord-023168-cd7adns8	929	18	treatment	treatment	NN
cord-023168-cd7adns8	929	19	.	.	.
cord-023168-cd7adns8	930	1	The	the	DT
cord-023168-cd7adns8	930	2	management	management	NN
cord-023168-cd7adns8	930	3	of	of	IN
cord-023168-cd7adns8	930	4	severe	severe	JJ
cord-023168-cd7adns8	930	5	malarial	malarial	JJ
cord-023168-cd7adns8	930	6	anaemia	anaemia	NN
cord-023168-cd7adns8	930	7	involves	involve	VBZ
cord-023168-cd7adns8	930	8	supportive	supportive	JJ
cord-023168-cd7adns8	930	9	care	care	NN
cord-023168-cd7adns8	930	10	and	and	CC
cord-023168-cd7adns8	930	11	treatment	treatment	NN
cord-023168-cd7adns8	930	12	of	of	IN
cord-023168-cd7adns8	930	13	the	the	DT
cord-023168-cd7adns8	930	14	malaria	malaria	NN
cord-023168-cd7adns8	930	15	and	and	CC
cord-023168-cd7adns8	930	16	any	any	DT
cord-023168-cd7adns8	930	17	other	other	JJ
cord-023168-cd7adns8	930	18	underlying	underlying	JJ
cord-023168-cd7adns8	930	19	conditions	condition	NNS
cord-023168-cd7adns8	930	20	.	.	.
cord-023168-cd7adns8	931	1	Recovery	recovery	NN
cord-023168-cd7adns8	931	2	from	from	IN
cord-023168-cd7adns8	931	3	malaria	malaria	NN
cord-023168-cd7adns8	931	4	-	-	HYPH
cord-023168-cd7adns8	931	5	associated	associate	VBN
cord-023168-cd7adns8	931	6	anaemia	anaemia	NN
cord-023168-cd7adns8	931	7	can	can	MD
cord-023168-cd7adns8	931	8	be	be	VB
cord-023168-cd7adns8	931	9	slow	slow	JJ
cord-023168-cd7adns8	931	10	,	,	,
cord-023168-cd7adns8	931	11	taking	take	VBG
cord-023168-cd7adns8	931	12	6	6	CD
cord-023168-cd7adns8	931	13	weeks	week	NNS
cord-023168-cd7adns8	931	14	or	or	CC
cord-023168-cd7adns8	931	15	even	even	RB
cord-023168-cd7adns8	931	16	longer	long	RBR
cord-023168-cd7adns8	931	17	if	if	IN
cord-023168-cd7adns8	931	18	there	there	EX
cord-023168-cd7adns8	931	19	are	be	VBP
cord-023168-cd7adns8	931	20	episodes	episode	NNS
cord-023168-cd7adns8	931	21	of	of	IN
cord-023168-cd7adns8	931	22	re	re	NN
cord-023168-cd7adns8	931	23	-	-	NN
cord-023168-cd7adns8	931	24	infection	infection	NN
cord-023168-cd7adns8	931	25	.	.	.
cord-023168-cd7adns8	932	1	212	212	CD
cord-023168-cd7adns8	933	1	In	in	IN
cord-023168-cd7adns8	933	2	children	child	NNS
cord-023168-cd7adns8	933	3	,	,	,
cord-023168-cd7adns8	933	4	blood	blood	NN
cord-023168-cd7adns8	933	5	transfusion	transfusion	NN
cord-023168-cd7adns8	933	6	is	be	VBZ
cord-023168-cd7adns8	933	7	usually	usually	RB
cord-023168-cd7adns8	933	8	reserved	reserve	VBN
cord-023168-cd7adns8	933	9	for	for	IN
cord-023168-cd7adns8	933	10	those	those	DT
cord-023168-cd7adns8	933	11	with	with	IN
cord-023168-cd7adns8	933	12	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	933	13	levels	level	NNS
cord-023168-cd7adns8	933	14	of	of	IN
cord-023168-cd7adns8	933	15	less	less	JJR
cord-023168-cd7adns8	933	16	than	than	IN
cord-023168-cd7adns8	933	17	40	40	CD
cord-023168-cd7adns8	933	18	g	g	NN
cord-023168-cd7adns8	933	19	/	/	SYM
cord-023168-cd7adns8	933	20	L	L	NNP
cord-023168-cd7adns8	933	21	(	(	-LRB-
cord-023168-cd7adns8	933	22	<	<	XX
cord-023168-cd7adns8	933	23	50	50	CD
cord-023168-cd7adns8	933	24	g	g	NN
cord-023168-cd7adns8	933	25	/	/	SYM
cord-023168-cd7adns8	933	26	L	l	NN
cord-023168-cd7adns8	933	27	if	if	IN
cord-023168-cd7adns8	933	28	there	there	EX
cord-023168-cd7adns8	933	29	are	be	VBP
cord-023168-cd7adns8	933	30	complications	complication	NNS
cord-023168-cd7adns8	933	31	such	such	JJ
cord-023168-cd7adns8	933	32	as	as	IN
cord-023168-cd7adns8	933	33	respiratory	respiratory	JJ
cord-023168-cd7adns8	933	34	distress	distress	NN
cord-023168-cd7adns8	933	35	207	207	CD
cord-023168-cd7adns8	933	36	)	)	-RRB-
cord-023168-cd7adns8	933	37	.	.	.
cord-023168-cd7adns8	934	1	There	there	EX
cord-023168-cd7adns8	934	2	of	of	IN
cord-023168-cd7adns8	934	3	parasitized	parasitize	VBN
cord-023168-cd7adns8	934	4	red	red	JJ
cord-023168-cd7adns8	934	5	cells	cell	NNS
cord-023168-cd7adns8	934	6	227	227	CD
cord-023168-cd7adns8	934	7	and	and	CC
cord-023168-cd7adns8	934	8	the	the	DT
cord-023168-cd7adns8	934	9	release	release	NN
cord-023168-cd7adns8	934	10	of	of	IN
cord-023168-cd7adns8	934	11	von	von	NNP
cord-023168-cd7adns8	934	12	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	934	13	factor	factor	NN
cord-023168-cd7adns8	934	14	multimers	multimer	NNS
cord-023168-cd7adns8	934	15	which	which	WDT
cord-023168-cd7adns8	934	16	cause	cause	VBP
cord-023168-cd7adns8	934	17	widespread	widespread	JJ
cord-023168-cd7adns8	934	18	platelet	platelet	NN
cord-023168-cd7adns8	934	19	aggregation	aggregation	NN
cord-023168-cd7adns8	934	20	leading	lead	VBG
cord-023168-cd7adns8	934	21	to	to	IN
cord-023168-cd7adns8	934	22	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	934	23	228	228	CD
cord-023168-cd7adns8	934	24	,	,	,
cord-023168-cd7adns8	934	25	84	84	CD
cord-023168-cd7adns8	934	26	,	,	,
cord-023168-cd7adns8	934	27	231	231	CD
cord-023168-cd7adns8	934	28	Platelet	platelet	NN
cord-023168-cd7adns8	934	29	synthesis	synthesis	NN
cord-023168-cd7adns8	934	30	by	by	IN
cord-023168-cd7adns8	934	31	the	the	DT
cord-023168-cd7adns8	934	32	bone	bone	NN
cord-023168-cd7adns8	934	33	marrow	marrow	NN
cord-023168-cd7adns8	934	34	is	be	VBZ
cord-023168-cd7adns8	934	35	relatively	relatively	RB
cord-023168-cd7adns8	934	36	well	well	RB
cord-023168-cd7adns8	934	37	maintained	maintain	VBN
cord-023168-cd7adns8	934	38	during	during	IN
cord-023168-cd7adns8	934	39	infection	infection	NN
cord-023168-cd7adns8	934	40	231	231	CD
cord-023168-cd7adns8	934	41	,	,	,
cord-023168-cd7adns8	934	42	229	229	CD
cord-023168-cd7adns8	934	43	but	but	CC
cord-023168-cd7adns8	934	44	antiplatelet	antiplatelet	JJ
cord-023168-cd7adns8	934	45	antibodies	antibody	NNS
cord-023168-cd7adns8	934	46	,	,	,
cord-023168-cd7adns8	934	47	immune	immune	JJ
cord-023168-cd7adns8	934	48	complexes	complex	NNS
cord-023168-cd7adns8	934	49	and	and	CC
cord-023168-cd7adns8	934	50	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	935	1	all	all	DT
cord-023168-cd7adns8	935	2	contribute	contribute	VBP
cord-023168-cd7adns8	935	3	to	to	IN
cord-023168-cd7adns8	935	4	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	935	5	.	.	.
cord-023168-cd7adns8	936	1	230	230	CD
cord-023168-cd7adns8	936	2	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	936	3	occurs	occur	VBZ
cord-023168-cd7adns8	936	4	in	in	IN
cord-023168-cd7adns8	936	5	60	60	CD
cord-023168-cd7adns8	936	6	-	-	SYM
cord-023168-cd7adns8	936	7	90	90	CD
cord-023168-cd7adns8	936	8	%	%	NN
cord-023168-cd7adns8	936	9	of	of	IN
cord-023168-cd7adns8	936	10	individuals	individual	NNS
cord-023168-cd7adns8	936	11	infected	infect	VBN
cord-023168-cd7adns8	936	12	with	with	IN
cord-023168-cd7adns8	936	13	malaria	malaria	NN
cord-023168-cd7adns8	936	14	irrespective	irrespective	RB
cord-023168-cd7adns8	936	15	of	of	IN
cord-023168-cd7adns8	936	16	the	the	DT
cord-023168-cd7adns8	936	17	species	specie	NNS
cord-023168-cd7adns8	936	18	of	of	IN
cord-023168-cd7adns8	936	19	plasmodium	plasmodium	NN
cord-023168-cd7adns8	936	20	.	.	.
cord-023168-cd7adns8	937	1	214	214	CD
cord-023168-cd7adns8	937	2	,	,	,
cord-023168-cd7adns8	937	3	231	231	CD
cord-023168-cd7adns8	937	4	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	937	5	in	in	IN
cord-023168-cd7adns8	937	6	febrile	febrile	JJ
cord-023168-cd7adns8	937	7	patients	patient	NNS
cord-023168-cd7adns8	937	8	in	in	IN
cord-023168-cd7adns8	937	9	an	an	DT
cord-023168-cd7adns8	937	10	endemic	endemic	JJ
cord-023168-cd7adns8	937	11	area	area	NN
cord-023168-cd7adns8	937	12	increases	increase	VBZ
cord-023168-cd7adns8	937	13	the	the	DT
cord-023168-cd7adns8	937	14	probability	probability	NN
cord-023168-cd7adns8	937	15	of	of	IN
cord-023168-cd7adns8	937	16	malaria	malaria	NN
cord-023168-cd7adns8	937	17	by	by	IN
cord-023168-cd7adns8	937	18	a	a	DT
cord-023168-cd7adns8	937	19	factor	factor	NN
cord-023168-cd7adns8	937	20	of	of	IN
cord-023168-cd7adns8	937	21	5	5	CD
cord-023168-cd7adns8	937	22	232	232	CD
cord-023168-cd7adns8	937	23	and	and	CC
cord-023168-cd7adns8	937	24	in	in	IN
cord-023168-cd7adns8	937	25	individuals	individual	NNS
cord-023168-cd7adns8	937	26	returning	return	VBG
cord-023168-cd7adns8	937	27	from	from	IN
cord-023168-cd7adns8	937	28	tropical	tropical	JJ
cord-023168-cd7adns8	937	29	countries	country	NNS
cord-023168-cd7adns8	937	30	with	with	IN
cord-023168-cd7adns8	937	31	a	a	DT
cord-023168-cd7adns8	937	32	fever	fever	NN
cord-023168-cd7adns8	937	33	,	,	,
cord-023168-cd7adns8	937	34	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	937	35	is	be	VBZ
cord-023168-cd7adns8	937	36	highly	highly	RB
cord-023168-cd7adns8	937	37	specific	specific	JJ
cord-023168-cd7adns8	937	38	for	for	IN
cord-023168-cd7adns8	937	39	malaria	malaria	NN
cord-023168-cd7adns8	937	40	infection	infection	NN
cord-023168-cd7adns8	937	41	.	.	.
cord-023168-cd7adns8	938	1	233	233	CD
cord-023168-cd7adns8	939	1	Profound	profound	JJ
cord-023168-cd7adns8	939	2	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	939	3	is	be	VBZ
cord-023168-cd7adns8	939	4	unusual	unusual	JJ
cord-023168-cd7adns8	939	5	and	and	CC
cord-023168-cd7adns8	939	6	malaria	malaria	NN
cord-023168-cd7adns8	939	7	-	-	HYPH
cord-023168-cd7adns8	939	8	associated	associate	VBN
cord-023168-cd7adns8	939	9	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	939	10	is	be	VBZ
cord-023168-cd7adns8	939	11	rarely	rarely	RB
cord-023168-cd7adns8	939	12	associated	associate	VBN
cord-023168-cd7adns8	939	13	with	with	IN
cord-023168-cd7adns8	939	14	haemorrhagic	haemorrhagic	JJ
cord-023168-cd7adns8	939	15	manifestations	manifestation	NNS
cord-023168-cd7adns8	939	16	.	.	.
cord-023168-cd7adns8	940	1	234	234	CD
cord-023168-cd7adns8	941	1	The	the	DT
cord-023168-cd7adns8	941	2	clinical	clinical	JJ
cord-023168-cd7adns8	941	3	consequences	consequence	NNS
cord-023168-cd7adns8	941	4	of	of	IN
cord-023168-cd7adns8	941	5	platelet	platelet	NN
cord-023168-cd7adns8	941	6	aggregation	aggregation	NN
cord-023168-cd7adns8	941	7	and	and	CC
cord-023168-cd7adns8	941	8	endothelial	endothelial	JJ
cord-023168-cd7adns8	941	9	binding	binding	NN
cord-023168-cd7adns8	941	10	are	be	VBP
cord-023168-cd7adns8	941	11	primarily	primarily	RB
cord-023168-cd7adns8	941	12	microvascular	microvascular	JJ
cord-023168-cd7adns8	941	13	ischaemia	ischaemia	NN
cord-023168-cd7adns8	941	14	.	.	.
cord-023168-cd7adns8	942	1	This	this	DT
cord-023168-cd7adns8	942	2	may	may	MD
cord-023168-cd7adns8	942	3	manifest	manifest	VB
cord-023168-cd7adns8	942	4	as	as	IN
cord-023168-cd7adns8	942	5	renal	renal	JJ
cord-023168-cd7adns8	942	6	impairment	impairment	NN
cord-023168-cd7adns8	942	7	,	,	,
cord-023168-cd7adns8	942	8	cerebral	cerebral	JJ
cord-023168-cd7adns8	942	9	ischaemia	ischaemia	NN
cord-023168-cd7adns8	942	10	,	,	,
cord-023168-cd7adns8	942	11	and	and	CC
cord-023168-cd7adns8	942	12	occlusion	occlusion	NN
cord-023168-cd7adns8	942	13	of	of	IN
cord-023168-cd7adns8	942	14	retinal	retinal	JJ
cord-023168-cd7adns8	942	15	vasculature	vasculature	NN
cord-023168-cd7adns8	942	16	or	or	CC
cord-023168-cd7adns8	942	17	even	even	RB
cord-023168-cd7adns8	942	18	in	in	IN
cord-023168-cd7adns8	942	19	some	some	DT
cord-023168-cd7adns8	942	20	cases	case	NNS
cord-023168-cd7adns8	942	21	,	,	,
cord-023168-cd7adns8	942	22	skin	skin	NN
cord-023168-cd7adns8	942	23	necrosis	necrosis	NN
cord-023168-cd7adns8	942	24	.	.	.
cord-023168-cd7adns8	943	1	Bleeding	bleed	VBG
cord-023168-cd7adns8	943	2	is	be	VBZ
cord-023168-cd7adns8	943	3	unlikely	unlikely	JJ
cord-023168-cd7adns8	943	4	,	,	,
cord-023168-cd7adns8	943	5	although	although	IN
cord-023168-cd7adns8	943	6	in	in	IN
cord-023168-cd7adns8	943	7	severe	severe	JJ
cord-023168-cd7adns8	943	8	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	943	9	,	,	,
cord-023168-cd7adns8	943	10	petechiae	petechia	NNS
cord-023168-cd7adns8	943	11	or	or	CC
cord-023168-cd7adns8	943	12	purpura	purpura	NN
cord-023168-cd7adns8	943	13	may	may	MD
cord-023168-cd7adns8	943	14	develop	develop	VB
cord-023168-cd7adns8	943	15	which	which	WDT
cord-023168-cd7adns8	943	16	denotes	denote	VBZ
cord-023168-cd7adns8	943	17	extravasation	extravasation	NN
cord-023168-cd7adns8	943	18	of	of	IN
cord-023168-cd7adns8	943	19	red	red	JJ
cord-023168-cd7adns8	943	20	cells	cell	NNS
cord-023168-cd7adns8	943	21	into	into	IN
cord-023168-cd7adns8	943	22	the	the	DT
cord-023168-cd7adns8	943	23	subcutaneous	subcutaneous	JJ
cord-023168-cd7adns8	943	24	tissue	tissue	NN
cord-023168-cd7adns8	943	25	.	.	.
cord-023168-cd7adns8	944	1	235	235	CD
cord-023168-cd7adns8	944	2	Continued	continued	JJ
cord-023168-cd7adns8	944	3	platelet	platelet	NN
cord-023168-cd7adns8	944	4	activation	activation	NN
cord-023168-cd7adns8	944	5	and	and	CC
cord-023168-cd7adns8	944	6	consumption	consumption	NN
cord-023168-cd7adns8	944	7	can	can	MD
cord-023168-cd7adns8	944	8	exacerbate	exacerbate	VB
cord-023168-cd7adns8	944	9	bleeding	bleed	VBG
cord-023168-cd7adns8	944	10	and	and	CC
cord-023168-cd7adns8	944	11	decreased	decrease	VBD
cord-023168-cd7adns8	944	12	circulating	circulate	VBG
cord-023168-cd7adns8	944	13	platelets	platelet	NNS
cord-023168-cd7adns8	944	14	are	be	VBP
cord-023168-cd7adns8	944	15	associated	associate	VBN
cord-023168-cd7adns8	944	16	with	with	IN
cord-023168-cd7adns8	944	17	increased	increase	VBN
cord-023168-cd7adns8	944	18	vascular	vascular	JJ
cord-023168-cd7adns8	944	19	leakage	leakage	NN
cord-023168-cd7adns8	944	20	and	and	CC
cord-023168-cd7adns8	944	21	the	the	DT
cord-023168-cd7adns8	944	22	development	development	NN
cord-023168-cd7adns8	944	23	of	of	IN
cord-023168-cd7adns8	944	24	oedema	oedema	NN
cord-023168-cd7adns8	944	25	.	.	.
cord-023168-cd7adns8	945	1	236	236	CD
cord-023168-cd7adns8	945	2	Platelet	platelet	NN
cord-023168-cd7adns8	945	3	transfusions	transfusion	NNS
cord-023168-cd7adns8	945	4	are	be	VBP
cord-023168-cd7adns8	945	5	rarely	rarely	RB
cord-023168-cd7adns8	945	6	required	require	VBN
cord-023168-cd7adns8	945	7	because	because	IN
cord-023168-cd7adns8	945	8	the	the	DT
cord-023168-cd7adns8	945	9	platelet	platelet	NN
cord-023168-cd7adns8	945	10	count	count	NN
cord-023168-cd7adns8	945	11	generally	generally	RB
cord-023168-cd7adns8	945	12	rises	rise	VBZ
cord-023168-cd7adns8	945	13	rapidly	rapidly	RB
cord-023168-cd7adns8	945	14	on	on	IN
cord-023168-cd7adns8	945	15	treating	treat	VBG
cord-023168-cd7adns8	945	16	the	the	DT
cord-023168-cd7adns8	945	17	underlying	underlie	VBG
cord-023168-cd7adns8	945	18	malaria	malaria	NN
cord-023168-cd7adns8	945	19	.	.	.
cord-023168-cd7adns8	946	1	Coagulopathy	Coagulopathy	NNP
cord-023168-cd7adns8	946	2	is	be	VBZ
cord-023168-cd7adns8	946	3	a	a	DT
cord-023168-cd7adns8	946	4	disturbance	disturbance	NN
cord-023168-cd7adns8	946	5	of	of	IN
cord-023168-cd7adns8	946	6	the	the	DT
cord-023168-cd7adns8	946	7	whole	whole	JJ
cord-023168-cd7adns8	946	8	coagulation	coagulation	NN
cord-023168-cd7adns8	946	9	system	system	NN
cord-023168-cd7adns8	946	10	involving	involve	VBG
cord-023168-cd7adns8	946	11	not	not	RB
cord-023168-cd7adns8	946	12	just	just	RB
cord-023168-cd7adns8	946	13	coagulation	coagulation	NN
cord-023168-cd7adns8	946	14	factors	factor	NNS
cord-023168-cd7adns8	946	15	but	but	CC
cord-023168-cd7adns8	946	16	platelets	platelet	NNS
cord-023168-cd7adns8	946	17	,	,	,
cord-023168-cd7adns8	946	18	anticoagulant	anticoagulant	NN
cord-023168-cd7adns8	946	19	factors	factor	NNS
cord-023168-cd7adns8	946	20	,	,	,
cord-023168-cd7adns8	946	21	fibrinolytic	fibrinolytic	JJ
cord-023168-cd7adns8	946	22	system	system	NN
cord-023168-cd7adns8	946	23	and	and	CC
cord-023168-cd7adns8	946	24	,	,	,
cord-023168-cd7adns8	946	25	in	in	IN
cord-023168-cd7adns8	946	26	the	the	DT
cord-023168-cd7adns8	946	27	case	case	NN
cord-023168-cd7adns8	946	28	of	of	IN
cord-023168-cd7adns8	946	29	malaria	malaria	NN
cord-023168-cd7adns8	946	30	,	,	,
cord-023168-cd7adns8	946	31	the	the	DT
cord-023168-cd7adns8	946	32	parasitized	parasitize	VBN
cord-023168-cd7adns8	946	33	red	red	JJ
cord-023168-cd7adns8	946	34	cells	cell	NNS
cord-023168-cd7adns8	946	35	and	and	CC
cord-023168-cd7adns8	946	36	the	the	DT
cord-023168-cd7adns8	946	37	vascular	vascular	JJ
cord-023168-cd7adns8	946	38	endothelium	endothelium	NN
cord-023168-cd7adns8	946	39	.	.	.
cord-023168-cd7adns8	947	1	Parasitized	parasitized	JJ
cord-023168-cd7adns8	947	2	red	red	JJ
cord-023168-cd7adns8	947	3	cells	cell	NNS
cord-023168-cd7adns8	947	4	induce	induce	VBP
cord-023168-cd7adns8	947	5	expression	expression	NN
cord-023168-cd7adns8	947	6	of	of	IN
cord-023168-cd7adns8	947	7	tissue	tissue	NN
cord-023168-cd7adns8	947	8	factor	factor	NN
cord-023168-cd7adns8	947	9	on	on	IN
cord-023168-cd7adns8	947	10	endothelial	endothelial	JJ
cord-023168-cd7adns8	947	11	cells	cell	NNS
cord-023168-cd7adns8	947	12	and	and	CC
cord-023168-cd7adns8	947	13	monocytes	monocyte	NNS
cord-023168-cd7adns8	947	14	,	,	,
cord-023168-cd7adns8	947	15	release	release	NN
cord-023168-cd7adns8	947	16	of	of	IN
cord-023168-cd7adns8	947	17	microparticles	microparticle	NNS
cord-023168-cd7adns8	947	18	,	,	,
cord-023168-cd7adns8	947	19	cytokine	cytokine	NN
cord-023168-cd7adns8	947	20	release	release	NN
cord-023168-cd7adns8	947	21	and	and	CC
cord-023168-cd7adns8	947	22	platelet	platelet	NN
cord-023168-cd7adns8	947	23	clumping	clumping	NN
cord-023168-cd7adns8	947	24	,	,	,
cord-023168-cd7adns8	947	25	all	all	DT
cord-023168-cd7adns8	947	26	of	of	IN
cord-023168-cd7adns8	947	27	which	which	WDT
cord-023168-cd7adns8	947	28	initiate	initiate	VBP
cord-023168-cd7adns8	947	29	blood	blood	NN
cord-023168-cd7adns8	947	30	coagulation	coagulation	NN
cord-023168-cd7adns8	947	31	and	and	CC
cord-023168-cd7adns8	947	32	tilt	tilt	VB
cord-023168-cd7adns8	947	33	the	the	DT
cord-023168-cd7adns8	947	34	balance	balance	NN
cord-023168-cd7adns8	947	35	towards	towards	IN
cord-023168-cd7adns8	947	36	the	the	DT
cord-023168-cd7adns8	947	37	pro	pro	JJ
cord-023168-cd7adns8	947	38	-	-	JJ
cord-023168-cd7adns8	947	39	coagulant	coagulant	JJ
cord-023168-cd7adns8	947	40	state	state	NN
cord-023168-cd7adns8	947	41	(	(	-LRB-
cord-023168-cd7adns8	947	42	Figure	Figure	NNP
cord-023168-cd7adns8	947	43	 	 	_SP
cord-023168-cd7adns8	947	44	65.12	65.12	CD
cord-023168-cd7adns8	947	45	)	)	-RRB-
cord-023168-cd7adns8	947	46	.	.	.
cord-023168-cd7adns8	948	1	234	234	CD
cord-023168-cd7adns8	948	2	,	,	,
cord-023168-cd7adns8	948	3	[	[	-LRB-
cord-023168-cd7adns8	948	4	237	237	CD
cord-023168-cd7adns8	948	5	]	]	-RRB-
cord-023168-cd7adns8	948	6	[	[	-LRB-
cord-023168-cd7adns8	948	7	238	238	CD
cord-023168-cd7adns8	948	8	]	]	-RRB-
cord-023168-cd7adns8	948	9	[	[	-LRB-
cord-023168-cd7adns8	948	10	239	239	CD
cord-023168-cd7adns8	948	11	]	]	-RRB-
cord-023168-cd7adns8	948	12	[	[	-LRB-
cord-023168-cd7adns8	948	13	240	240	CD
cord-023168-cd7adns8	948	14	]	]	-RRB-
cord-023168-cd7adns8	948	15	[	[	-LRB-
cord-023168-cd7adns8	948	16	241	241	CD
cord-023168-cd7adns8	948	17	]	]	-RRB-
cord-023168-cd7adns8	948	18	[	[	-LRB-
cord-023168-cd7adns8	948	19	242	242	CD
cord-023168-cd7adns8	948	20	]	]	-RRB-
cord-023168-cd7adns8	949	1	Anticoagulant	anticoagulant	JJ
cord-023168-cd7adns8	949	2	factors	factor	NNS
cord-023168-cd7adns8	949	3	are	be	VBP
cord-023168-cd7adns8	949	4	severely	severely	RB
cord-023168-cd7adns8	949	5	depleted	deplete	VBN
cord-023168-cd7adns8	949	6	in	in	IN
cord-023168-cd7adns8	949	7	malaria	malaria	NN
cord-023168-cd7adns8	949	8	.	.	.
cord-023168-cd7adns8	950	1	Protein	protein	NN
cord-023168-cd7adns8	950	2	C	c	NN
cord-023168-cd7adns8	950	3	and	and	CC
cord-023168-cd7adns8	950	4	antithrombin	antithrombin	NN
cord-023168-cd7adns8	950	5	levels	level	NNS
cord-023168-cd7adns8	950	6	are	be	VBP
cord-023168-cd7adns8	950	7	inversely	inversely	RB
cord-023168-cd7adns8	950	8	correlated	correlate	VBN
cord-023168-cd7adns8	950	9	with	with	IN
cord-023168-cd7adns8	950	10	severity	severity	NN
cord-023168-cd7adns8	950	11	of	of	IN
cord-023168-cd7adns8	950	12	falciparum	falciparum	NN
cord-023168-cd7adns8	950	13	malaria	malaria	NN
cord-023168-cd7adns8	950	14	and	and	CC
cord-023168-cd7adns8	950	15	return	return	VB
cord-023168-cd7adns8	950	16	to	to	IN
cord-023168-cd7adns8	950	17	normal	normal	JJ
cord-023168-cd7adns8	950	18	with	with	IN
cord-023168-cd7adns8	950	19	treatment	treatment	NN
cord-023168-cd7adns8	950	20	of	of	IN
cord-023168-cd7adns8	950	21	the	the	DT
cord-023168-cd7adns8	950	22	malaria	malaria	NN
cord-023168-cd7adns8	950	23	.	.	.
cord-023168-cd7adns8	951	1	245	245	CD
cord-023168-cd7adns8	951	2	have	have	VBP
cord-023168-cd7adns8	951	3	been	be	VBN
cord-023168-cd7adns8	951	4	some	some	DT
cord-023168-cd7adns8	951	5	concerns	concern	NNS
cord-023168-cd7adns8	951	6	about	about	IN
cord-023168-cd7adns8	951	7	a	a	DT
cord-023168-cd7adns8	951	8	possible	possible	JJ
cord-023168-cd7adns8	951	9	increased	increase	VBN
cord-023168-cd7adns8	951	10	risk	risk	NN
cord-023168-cd7adns8	951	11	of	of	IN
cord-023168-cd7adns8	951	12	infection	infection	NN
cord-023168-cd7adns8	951	13	associated	associate	VBN
cord-023168-cd7adns8	951	14	with	with	IN
cord-023168-cd7adns8	951	15	iron	iron	NN
cord-023168-cd7adns8	951	16	supplementation	supplementation	NN
cord-023168-cd7adns8	951	17	for	for	IN
cord-023168-cd7adns8	951	18	children	child	NNS
cord-023168-cd7adns8	951	19	in	in	IN
cord-023168-cd7adns8	951	20	malarious	malarious	JJ
cord-023168-cd7adns8	951	21	areas	area	NNS
cord-023168-cd7adns8	951	22	218	218	CD
cord-023168-cd7adns8	951	23	,	,	,
cord-023168-cd7adns8	951	24	219	219	CD
cord-023168-cd7adns8	951	25	but	but	CC
cord-023168-cd7adns8	951	26	current	current	JJ
cord-023168-cd7adns8	951	27	recommendations	recommendation	NNS
cord-023168-cd7adns8	951	28	advocate	advocate	VBP
cord-023168-cd7adns8	951	29	that	that	IN
cord-023168-cd7adns8	951	30	where	where	WRB
cord-023168-cd7adns8	951	31	iron	iron	NN
cord-023168-cd7adns8	951	32	deficiency	deficiency	NN
cord-023168-cd7adns8	951	33	and	and	CC
cord-023168-cd7adns8	951	34	malaria	malaria	NN
cord-023168-cd7adns8	951	35	are	be	VBP
cord-023168-cd7adns8	951	36	common	common	JJ
cord-023168-cd7adns8	951	37	,	,	,
cord-023168-cd7adns8	951	38	iron	iron	NN
cord-023168-cd7adns8	951	39	supplements	supplement	NNS
cord-023168-cd7adns8	951	40	should	should	MD
cord-023168-cd7adns8	951	41	not	not	RB
cord-023168-cd7adns8	951	42	be	be	VB
cord-023168-cd7adns8	951	43	withheld	withhold	VBN
cord-023168-cd7adns8	951	44	and	and	CC
cord-023168-cd7adns8	951	45	appropriate	appropriate	JJ
cord-023168-cd7adns8	951	46	anti	anti	JJ
cord-023168-cd7adns8	951	47	-	-	JJ
cord-023168-cd7adns8	951	48	malarial	malarial	JJ
cord-023168-cd7adns8	951	49	treatment	treatment	NN
cord-023168-cd7adns8	951	50	or	or	CC
cord-023168-cd7adns8	951	51	prevention	prevention	NN
cord-023168-cd7adns8	951	52	should	should	MD
cord-023168-cd7adns8	951	53	also	also	RB
cord-023168-cd7adns8	951	54	be	be	VB
cord-023168-cd7adns8	951	55	offered	offer	VBN
cord-023168-cd7adns8	951	56	.	.	.
cord-023168-cd7adns8	952	1	220	220	CD
cord-023168-cd7adns8	953	1	The	the	DT
cord-023168-cd7adns8	953	2	best	good	JJS
cord-023168-cd7adns8	953	3	way	way	NN
cord-023168-cd7adns8	953	4	to	to	TO
cord-023168-cd7adns8	953	5	prevent	prevent	VB
cord-023168-cd7adns8	953	6	malarial	malarial	JJ
cord-023168-cd7adns8	953	7	anaemia	anaemia	NN
cord-023168-cd7adns8	953	8	is	be	VBZ
cord-023168-cd7adns8	953	9	to	to	TO
cord-023168-cd7adns8	953	10	prevent	prevent	VB
cord-023168-cd7adns8	953	11	malaria	malaria	NN
cord-023168-cd7adns8	953	12	infection	infection	NN
cord-023168-cd7adns8	953	13	by	by	IN
cord-023168-cd7adns8	953	14	avoiding	avoid	VBG
cord-023168-cd7adns8	953	15	mosquito	mosquito	NN
cord-023168-cd7adns8	953	16	bites	bite	NNS
cord-023168-cd7adns8	953	17	(	(	-LRB-
cord-023168-cd7adns8	953	18	e.g.	e.g.	RB
cord-023168-cd7adns8	953	19	through	through	IN
cord-023168-cd7adns8	953	20	the	the	DT
cord-023168-cd7adns8	953	21	use	use	NN
cord-023168-cd7adns8	953	22	of	of	IN
cord-023168-cd7adns8	953	23	bed	bed	NN
cord-023168-cd7adns8	953	24	nets	net	NNS
cord-023168-cd7adns8	953	25	)	)	-RRB-
cord-023168-cd7adns8	953	26	or	or	CC
cord-023168-cd7adns8	953	27	through	through	IN
cord-023168-cd7adns8	953	28	chemoprophylaxis	chemoprophylaxis	NNP
cord-023168-cd7adns8	953	29	.	.	.
cord-023168-cd7adns8	954	1	Malaria	malaria	NN
cord-023168-cd7adns8	954	2	chemoprophylaxis	chemoprophylaxis	NNP
cord-023168-cd7adns8	954	3	during	during	IN
cord-023168-cd7adns8	954	4	infancy	infancy	NN
cord-023168-cd7adns8	954	5	can	can	MD
cord-023168-cd7adns8	954	6	reduce	reduce	VB
cord-023168-cd7adns8	954	7	both	both	DT
cord-023168-cd7adns8	954	8	malaria	malaria	NN
cord-023168-cd7adns8	954	9	and	and	CC
cord-023168-cd7adns8	954	10	anaemia	anaemia	NN
cord-023168-cd7adns8	954	11	.	.	.
cord-023168-cd7adns8	955	1	221	221	CD
cord-023168-cd7adns8	955	2	Children	child	NNS
cord-023168-cd7adns8	955	3	who	who	WP
cord-023168-cd7adns8	955	4	have	have	VBP
cord-023168-cd7adns8	955	5	been	be	VBN
cord-023168-cd7adns8	955	6	hospitalized	hospitalize	VBN
cord-023168-cd7adns8	955	7	with	with	IN
cord-023168-cd7adns8	955	8	severe	severe	JJ
cord-023168-cd7adns8	955	9	malarial	malarial	JJ
cord-023168-cd7adns8	955	10	anaemia	anaemia	NN
cord-023168-cd7adns8	955	11	may	may	MD
cord-023168-cd7adns8	955	12	benefit	benefit	VB
cord-023168-cd7adns8	955	13	from	from	IN
cord-023168-cd7adns8	955	14	intermittent	intermittent	JJ
cord-023168-cd7adns8	955	15	preventive	preventive	JJ
cord-023168-cd7adns8	955	16	malarial	malarial	JJ
cord-023168-cd7adns8	955	17	therapy	therapy	NN
cord-023168-cd7adns8	955	18	after	after	IN
cord-023168-cd7adns8	955	19	discharge	discharge	NN
cord-023168-cd7adns8	955	20	to	to	TO
cord-023168-cd7adns8	955	21	prevent	prevent	VB
cord-023168-cd7adns8	955	22	recurrence	recurrence	NN
cord-023168-cd7adns8	955	23	of	of	IN
cord-023168-cd7adns8	955	24	anaemia	anaemia	NN
cord-023168-cd7adns8	955	25	.	.	.
cord-023168-cd7adns8	956	1	222	222	CD
cord-023168-cd7adns8	957	1	Daily	Daily	NNP
cord-023168-cd7adns8	957	2	co	co	JJ
cord-023168-cd7adns8	957	3	-	-	JJ
cord-023168-cd7adns8	957	4	trimoxazole	trimoxazole	JJ
cord-023168-cd7adns8	957	5	prophylaxis	prophylaxis	NN
cord-023168-cd7adns8	957	6	which	which	WDT
cord-023168-cd7adns8	957	7	is	be	VBZ
cord-023168-cd7adns8	957	8	used	use	VBN
cord-023168-cd7adns8	957	9	for	for	IN
cord-023168-cd7adns8	957	10	HIV	HIV	NNP
cord-023168-cd7adns8	957	11	-	-	HYPH
cord-023168-cd7adns8	957	12	infected	infect	VBN
cord-023168-cd7adns8	957	13	individuals	individual	NNS
cord-023168-cd7adns8	957	14	has	have	VBZ
cord-023168-cd7adns8	957	15	been	be	VBN
cord-023168-cd7adns8	957	16	shown	show	VBN
cord-023168-cd7adns8	957	17	to	to	TO
cord-023168-cd7adns8	957	18	reduce	reduce	VB
cord-023168-cd7adns8	957	19	malaria	malaria	NN
cord-023168-cd7adns8	957	20	parasitaemia	parasitaemia	NN
cord-023168-cd7adns8	957	21	and	and	CC
cord-023168-cd7adns8	957	22	anaemia	anaemia	NN
cord-023168-cd7adns8	957	23	.	.	.
cord-023168-cd7adns8	958	1	223	223	CD
cord-023168-cd7adns8	958	2	 	 	_SP
cord-023168-cd7adns8	959	1	The	the	DT
cord-023168-cd7adns8	959	2	normal	normal	JJ
cord-023168-cd7adns8	959	3	platelet	platelet	NN
cord-023168-cd7adns8	959	4	life	life	NN
cord-023168-cd7adns8	959	5	span	span	NN
cord-023168-cd7adns8	959	6	of	of	IN
cord-023168-cd7adns8	959	7	7	7	CD
cord-023168-cd7adns8	959	8	-	-	SYM
cord-023168-cd7adns8	959	9	10	10	CD
cord-023168-cd7adns8	959	10	days	day	NNS
cord-023168-cd7adns8	959	11	is	be	VBZ
cord-023168-cd7adns8	959	12	reduced	reduce	VBN
cord-023168-cd7adns8	959	13	to	to	IN
cord-023168-cd7adns8	959	14	less	less	JJR
cord-023168-cd7adns8	959	15	than	than	IN
cord-023168-cd7adns8	959	16	4	4	CD
cord-023168-cd7adns8	959	17	days	day	NNS
cord-023168-cd7adns8	959	18	in	in	IN
cord-023168-cd7adns8	959	19	malaria	malaria	NN
cord-023168-cd7adns8	959	20	infection	infection	NN
cord-023168-cd7adns8	959	21	.	.	.
cord-023168-cd7adns8	960	1	224	224	CD
cord-023168-cd7adns8	960	2	Several	several	JJ
cord-023168-cd7adns8	960	3	factors	factor	NNS
cord-023168-cd7adns8	960	4	are	be	VBP
cord-023168-cd7adns8	960	5	responsible	responsible	JJ
cord-023168-cd7adns8	960	6	for	for	IN
cord-023168-cd7adns8	960	7	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	960	8	in	in	IN
cord-023168-cd7adns8	960	9	malaria	malaria	NN
cord-023168-cd7adns8	960	10	infection	infection	NN
cord-023168-cd7adns8	960	11	,	,	,
cord-023168-cd7adns8	960	12	the	the	DT
cord-023168-cd7adns8	960	13	most	most	RBS
cord-023168-cd7adns8	960	14	common	common	JJ
cord-023168-cd7adns8	960	15	being	be	VBG
cord-023168-cd7adns8	960	16	increased	increase	VBN
cord-023168-cd7adns8	960	17	platelet	platelet	NN
cord-023168-cd7adns8	960	18	activation	activation	NN
cord-023168-cd7adns8	960	19	and	and	CC
cord-023168-cd7adns8	960	20	aggregation	aggregation	NN
cord-023168-cd7adns8	960	21	(	(	-LRB-
cord-023168-cd7adns8	960	22	Figure	figure	VB
cord-023168-cd7adns8	960	23	 	 	_SP
cord-023168-cd7adns8	960	24	65	65	CD
cord-023168-cd7adns8	960	25	.11	.11	CD
cord-023168-cd7adns8	960	26	)	)	-RRB-
cord-023168-cd7adns8	960	27	.	.	.
cord-023168-cd7adns8	961	1	225	225	CD
cord-023168-cd7adns8	961	2	Platelet	platelet	NN
cord-023168-cd7adns8	961	3	activation	activation	NN
cord-023168-cd7adns8	961	4	is	be	VBZ
cord-023168-cd7adns8	961	5	by	by	IN
cord-023168-cd7adns8	961	6	parasitized	parasitize	VBN
cord-023168-cd7adns8	961	7	red	red	JJ
cord-023168-cd7adns8	961	8	cells	cell	NNS
cord-023168-cd7adns8	961	9	which	which	WDT
cord-023168-cd7adns8	961	10	express	express	VBP
cord-023168-cd7adns8	961	11	surface	surface	NN
cord-023168-cd7adns8	961	12	tissue	tissue	NN
cord-023168-cd7adns8	961	13	factor	factor	NN
cord-023168-cd7adns8	961	14	and	and	CC
cord-023168-cd7adns8	961	15	initiate	initiate	VB
cord-023168-cd7adns8	961	16	coagulation	coagulation	NN
cord-023168-cd7adns8	961	17	and	and	CC
cord-023168-cd7adns8	961	18	platelet	platelet	NN
cord-023168-cd7adns8	961	19	aggregation	aggregation	NN
cord-023168-cd7adns8	961	20	.	.	.
cord-023168-cd7adns8	962	1	The	the	DT
cord-023168-cd7adns8	962	2	resultant	resultant	JJ
cord-023168-cd7adns8	962	3	activated	activate	VBN
cord-023168-cd7adns8	962	4	endothelium	endothelium	NN
cord-023168-cd7adns8	962	5	binds	bind	VBZ
cord-023168-cd7adns8	962	6	platelets	platelet	NNS
cord-023168-cd7adns8	962	7	and	and	CC
cord-023168-cd7adns8	962	8	sequesters	sequester	VBZ
cord-023168-cd7adns8	962	9	them	-PRON-	PRP
cord-023168-cd7adns8	962	10	in	in	IN
cord-023168-cd7adns8	962	11	vascular	vascular	JJ
cord-023168-cd7adns8	962	12	beds	bed	NNS
cord-023168-cd7adns8	962	13	including	include	VBG
cord-023168-cd7adns8	962	14	in	in	IN
cord-023168-cd7adns8	962	15	the	the	DT
cord-023168-cd7adns8	962	16	cerebral	cerebral	JJ
cord-023168-cd7adns8	962	17	vasculature	vasculature	NN
cord-023168-cd7adns8	962	18	.	.	.
cord-023168-cd7adns8	963	1	226	226	CD
cord-023168-cd7adns8	963	2	,	,	,
cord-023168-cd7adns8	963	3	234	234	CD
cord-023168-cd7adns8	964	1	These	these	DT
cord-023168-cd7adns8	964	2	platelets	platelet	NNS
cord-023168-cd7adns8	964	3	facilitate	facilitate	VBP
cord-023168-cd7adns8	964	4	the	the	DT
cord-023168-cd7adns8	964	5	adhesion	adhesion	NN
cord-023168-cd7adns8	964	6	and	and	CC
cord-023168-cd7adns8	964	7	to	to	IN
cord-023168-cd7adns8	964	8	46	46	CD
cord-023168-cd7adns8	964	9	%	%	NN
cord-023168-cd7adns8	964	10	after	after	IN
cord-023168-cd7adns8	964	11	a	a	DT
cord-023168-cd7adns8	964	12	year	year	NN
cord-023168-cd7adns8	964	13	.	.	.
cord-023168-cd7adns8	965	1	253	253	CD
cord-023168-cd7adns8	965	2	,	,	,
cord-023168-cd7adns8	965	3	247	247	CD
cord-023168-cd7adns8	966	1	Although	although	IN
cord-023168-cd7adns8	966	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	966	3	may	may	MD
cord-023168-cd7adns8	966	4	be	be	VB
cord-023168-cd7adns8	966	5	required	require	VBN
cord-023168-cd7adns8	966	6	in	in	IN
cord-023168-cd7adns8	966	7	severe	severe	JJ
cord-023168-cd7adns8	966	8	life	life	NN
cord-023168-cd7adns8	966	9	-	-	HYPH
cord-023168-cd7adns8	966	10	threatening	threaten	VBG
cord-023168-cd7adns8	966	11	cases	case	NNS
cord-023168-cd7adns8	966	12	of	of	IN
cord-023168-cd7adns8	966	13	anaemia	anaemia	NN
cord-023168-cd7adns8	966	14	,	,	,
cord-023168-cd7adns8	966	15	aggressive	aggressive	JJ
cord-023168-cd7adns8	966	16	transfusion	transfusion	NN
cord-023168-cd7adns8	966	17	therapy	therapy	NN
cord-023168-cd7adns8	966	18	has	have	VBZ
cord-023168-cd7adns8	966	19	been	be	VBN
cord-023168-cd7adns8	966	20	associated	associate	VBN
cord-023168-cd7adns8	966	21	with	with	IN
cord-023168-cd7adns8	966	22	fatal	fatal	JJ
cord-023168-cd7adns8	966	23	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	966	24	emboli	emboli	NN
cord-023168-cd7adns8	966	25	due	due	IN
cord-023168-cd7adns8	966	26	to	to	IN
cord-023168-cd7adns8	966	27	accelerated	accelerated	JJ
cord-023168-cd7adns8	966	28	haemolysis	haemolysis	NN
cord-023168-cd7adns8	966	29	and	and	CC
cord-023168-cd7adns8	966	30	disseminated	disseminate	VBN
cord-023168-cd7adns8	966	31	intravascular	intravascular	JJ
cord-023168-cd7adns8	966	32	coagulation	coagulation	NN
cord-023168-cd7adns8	966	33	.	.	.
cord-023168-cd7adns8	967	1	254	254	CD
cord-023168-cd7adns8	968	1	In	in	IN
cord-023168-cd7adns8	968	2	those	those	DT
cord-023168-cd7adns8	968	3	who	who	WP
cord-023168-cd7adns8	968	4	do	do	VBP
cord-023168-cd7adns8	968	5	not	not	RB
cord-023168-cd7adns8	968	6	respond	respond	VB
cord-023168-cd7adns8	968	7	to	to	IN
cord-023168-cd7adns8	968	8	ART	art	NN
cord-023168-cd7adns8	968	9	,	,	,
cord-023168-cd7adns8	968	10	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	968	11	may	may	MD
cord-023168-cd7adns8	968	12	be	be	VB
cord-023168-cd7adns8	968	13	considered	consider	VBN
cord-023168-cd7adns8	968	14	since	since	IN
cord-023168-cd7adns8	968	15	reduced	reduce	VBN
cord-023168-cd7adns8	968	16	responsiveness	responsiveness	NN
cord-023168-cd7adns8	968	17	to	to	IN
cord-023168-cd7adns8	968	18	this	this	DT
cord-023168-cd7adns8	968	19	hormone	hormone	NN
cord-023168-cd7adns8	968	20	and	and	CC
cord-023168-cd7adns8	968	21	antierythropoietin	antierythropoietin	NN
cord-023168-cd7adns8	968	22	antibodies	antibody	NNS
cord-023168-cd7adns8	968	23	have	have	VBP
cord-023168-cd7adns8	968	24	been	be	VBN
cord-023168-cd7adns8	968	25	noted	note	VBN
cord-023168-cd7adns8	968	26	in	in	IN
cord-023168-cd7adns8	968	27	HIV	HIV	NNP
cord-023168-cd7adns8	968	28	patients	patient	NNS
cord-023168-cd7adns8	968	29	.	.	.
cord-023168-cd7adns8	969	1	Erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	969	2	is	be	VBZ
cord-023168-cd7adns8	969	3	particularly	particularly	RB
cord-023168-cd7adns8	969	4	useful	useful	JJ
cord-023168-cd7adns8	969	5	in	in	IN
cord-023168-cd7adns8	969	6	individuals	individual	NNS
cord-023168-cd7adns8	969	7	whose	whose	WP$
cord-023168-cd7adns8	969	8	erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	969	9	levels	level	NNS
cord-023168-cd7adns8	969	10	are	be	VBP
cord-023168-cd7adns8	969	11	less	less	JJR
cord-023168-cd7adns8	969	12	than	than	IN
cord-023168-cd7adns8	969	13	500	500	CD
cord-023168-cd7adns8	969	14	IU	IU	NNP
cord-023168-cd7adns8	969	15	/	/	SYM
cord-023168-cd7adns8	969	16	L	l	NN
cord-023168-cd7adns8	969	17	255	255	CD
cord-023168-cd7adns8	969	18	because	because	IN
cord-023168-cd7adns8	969	19	in	in	IN
cord-023168-cd7adns8	969	20	addition	addition	NN
cord-023168-cd7adns8	969	21	to	to	IN
cord-023168-cd7adns8	969	22	increasing	increase	VBG
cord-023168-cd7adns8	969	23	the	the	DT
cord-023168-cd7adns8	969	24	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	969	25	it	-PRON-	PRP
cord-023168-cd7adns8	969	26	can	can	MD
cord-023168-cd7adns8	969	27	also	also	RB
cord-023168-cd7adns8	969	28	improve	improve	VB
cord-023168-cd7adns8	969	29	the	the	DT
cord-023168-cd7adns8	969	30	quality	quality	NN
cord-023168-cd7adns8	969	31	of	of	IN
cord-023168-cd7adns8	969	32	life	life	NN
cord-023168-cd7adns8	969	33	.	.	.
cord-023168-cd7adns8	970	1	256	256	CD
cord-023168-cd7adns8	971	1	Erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	971	2	may	may	MD
cord-023168-cd7adns8	971	3	take	take	VB
cord-023168-cd7adns8	971	4	several	several	JJ
cord-023168-cd7adns8	971	5	weeks	week	NNS
cord-023168-cd7adns8	971	6	to	to	TO
cord-023168-cd7adns8	971	7	achieve	achieve	VB
cord-023168-cd7adns8	971	8	full	full	JJ
cord-023168-cd7adns8	971	9	effect	effect	NN
cord-023168-cd7adns8	971	10	and	and	CC
cord-023168-cd7adns8	971	11	patients	patient	NNS
cord-023168-cd7adns8	971	12	should	should	MD
cord-023168-cd7adns8	971	13	be	be	VB
cord-023168-cd7adns8	971	14	replete	replete	JJ
cord-023168-cd7adns8	971	15	in	in	IN
cord-023168-cd7adns8	971	16	haematinics	haematinic	NNS
cord-023168-cd7adns8	971	17	.	.	.
cord-023168-cd7adns8	972	1	Erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	972	2	can	can	MD
cord-023168-cd7adns8	972	3	very	very	RB
cord-023168-cd7adns8	972	4	rarely	rarely	RB
cord-023168-cd7adns8	972	5	be	be	VB
cord-023168-cd7adns8	972	6	associated	associate	VBN
cord-023168-cd7adns8	972	7	with	with	IN
cord-023168-cd7adns8	972	8	thrombosis	thrombosis	NN
cord-023168-cd7adns8	972	9	or	or	CC
cord-023168-cd7adns8	972	10	pure	pure	JJ
cord-023168-cd7adns8	972	11	red	red	JJ
cord-023168-cd7adns8	972	12	cell	cell	NN
cord-023168-cd7adns8	972	13	aplasia	aplasia	NNP
cord-023168-cd7adns8	972	14	.	.	.
cord-023168-cd7adns8	973	1	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	973	2	is	be	VBZ
cord-023168-cd7adns8	973	3	a	a	DT
cord-023168-cd7adns8	973	4	common	common	JJ
cord-023168-cd7adns8	973	5	finding	finding	NN
cord-023168-cd7adns8	973	6	in	in	IN
cord-023168-cd7adns8	973	7	HIV	HIV	NNP
cord-023168-cd7adns8	973	8	-	-	HYPH
cord-023168-cd7adns8	973	9	infected	infect	VBN
cord-023168-cd7adns8	973	10	patients	patient	NNS
cord-023168-cd7adns8	973	11	and	and	CC
cord-023168-cd7adns8	973	12	it	-PRON-	PRP
cord-023168-cd7adns8	973	13	may	may	MD
cord-023168-cd7adns8	973	14	be	be	VB
cord-023168-cd7adns8	973	15	the	the	DT
cord-023168-cd7adns8	973	16	initial	initial	JJ
cord-023168-cd7adns8	973	17	manifestation	manifestation	NN
cord-023168-cd7adns8	973	18	of	of	IN
cord-023168-cd7adns8	973	19	HIV	HIV	NNP
cord-023168-cd7adns8	973	20	infection	infection	NN
cord-023168-cd7adns8	973	21	in	in	IN
cord-023168-cd7adns8	973	22	as	as	RB
cord-023168-cd7adns8	973	23	many	many	JJ
cord-023168-cd7adns8	973	24	as	as	IN
cord-023168-cd7adns8	973	25	10	10	CD
cord-023168-cd7adns8	973	26	%	%	NN
cord-023168-cd7adns8	973	27	of	of	IN
cord-023168-cd7adns8	973	28	patients	patient	NNS
cord-023168-cd7adns8	973	29	.	.	.
cord-023168-cd7adns8	974	1	Data	datum	NNS
cord-023168-cd7adns8	974	2	from	from	IN
cord-023168-cd7adns8	974	3	wealthy	wealthy	JJ
cord-023168-cd7adns8	974	4	countries	country	NNS
cord-023168-cd7adns8	974	5	demonstrate	demonstrate	VBP
cord-023168-cd7adns8	974	6	platelet	platelet	NN
cord-023168-cd7adns8	974	7	counts	count	VBZ
cord-023168-cd7adns8	974	8	less	less	JJR
cord-023168-cd7adns8	974	9	than	than	IN
cord-023168-cd7adns8	974	10	150	150	CD
cord-023168-cd7adns8	974	11	×	×	NN
cord-023168-cd7adns8	974	12	10	10	CD
cord-023168-cd7adns8	974	13	9	9	CD
cord-023168-cd7adns8	974	14	/L	/l	CD
cord-023168-cd7adns8	974	15	in	in	IN
cord-023168-cd7adns8	974	16	11	11	CD
cord-023168-cd7adns8	974	17	%	%	NN
cord-023168-cd7adns8	974	18	of	of	IN
cord-023168-cd7adns8	974	19	patients	patient	NNS
cord-023168-cd7adns8	974	20	,	,	,
cord-023168-cd7adns8	974	21	and	and	CC
cord-023168-cd7adns8	974	22	less	less	JJR
cord-023168-cd7adns8	974	23	than	than	IN
cord-023168-cd7adns8	974	24	50	50	CD
cord-023168-cd7adns8	974	25	×	×	NN
cord-023168-cd7adns8	974	26	10	10	CD
cord-023168-cd7adns8	974	27	9	9	CD
cord-023168-cd7adns8	974	28	/L	/L	.
cord-023168-cd7adns8	974	29	in	in	IN
cord-023168-cd7adns8	974	30	1.5	1.5	CD
cord-023168-cd7adns8	974	31	%	%	NN
cord-023168-cd7adns8	974	32	.	.	.
cord-023168-cd7adns8	975	1	Overall	overall	RB
cord-023168-cd7adns8	975	2	the	the	DT
cord-023168-cd7adns8	975	3	1-year	1-year	CD
cord-023168-cd7adns8	975	4	Coagulopathy	Coagulopathy	NNP
cord-023168-cd7adns8	975	5	in	in	IN
cord-023168-cd7adns8	975	6	malaria	malaria	NN
cord-023168-cd7adns8	975	7	infection	infection	NN
cord-023168-cd7adns8	975	8	is	be	VBZ
cord-023168-cd7adns8	975	9	unusual	unusual	JJ
cord-023168-cd7adns8	975	10	,	,	,
cord-023168-cd7adns8	975	11	occurring	occur	VBG
cord-023168-cd7adns8	975	12	in	in	IN
cord-023168-cd7adns8	975	13	less	less	JJR
cord-023168-cd7adns8	975	14	than	than	IN
cord-023168-cd7adns8	975	15	5	5	CD
cord-023168-cd7adns8	975	16	%	%	NN
cord-023168-cd7adns8	975	17	of	of	IN
cord-023168-cd7adns8	975	18	cases	case	NNS
cord-023168-cd7adns8	975	19	.	.	.
cord-023168-cd7adns8	976	1	It	-PRON-	PRP
cord-023168-cd7adns8	976	2	appears	appear	VBZ
cord-023168-cd7adns8	976	3	to	to	TO
cord-023168-cd7adns8	976	4	be	be	VB
cord-023168-cd7adns8	976	5	most	most	RBS
cord-023168-cd7adns8	976	6	common	common	JJ
cord-023168-cd7adns8	976	7	in	in	IN
cord-023168-cd7adns8	976	8	adults	adult	NNS
cord-023168-cd7adns8	976	9	with	with	IN
cord-023168-cd7adns8	976	10	cerebral	cerebral	JJ
cord-023168-cd7adns8	976	11	malaria	malaria	NN
cord-023168-cd7adns8	976	12	who	who	WP
cord-023168-cd7adns8	976	13	may	may	MD
cord-023168-cd7adns8	976	14	present	present	VB
cord-023168-cd7adns8	976	15	with	with	IN
cord-023168-cd7adns8	976	16	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	976	17	bleeding	bleed	VBG
cord-023168-cd7adns8	976	18	243	243	CD
cord-023168-cd7adns8	976	19	or	or	CC
cord-023168-cd7adns8	976	20	with	with	IN
cord-023168-cd7adns8	976	21	microvascular	microvascular	JJ
cord-023168-cd7adns8	976	22	ischaemia	ischaemia	NN
cord-023168-cd7adns8	976	23	in	in	IN
cord-023168-cd7adns8	976	24	the	the	DT
cord-023168-cd7adns8	976	25	brain	brain	NN
cord-023168-cd7adns8	976	26	,	,	,
cord-023168-cd7adns8	976	27	kidneys	kidney	NNS
cord-023168-cd7adns8	976	28	,	,	,
cord-023168-cd7adns8	976	29	retina	retina	NN
cord-023168-cd7adns8	976	30	and	and	CC
cord-023168-cd7adns8	976	31	occasionally	occasionally	RB
cord-023168-cd7adns8	976	32	,	,	,
cord-023168-cd7adns8	976	33	the	the	DT
cord-023168-cd7adns8	976	34	dermal	dermal	JJ
cord-023168-cd7adns8	976	35	vasculature	vasculature	NN
cord-023168-cd7adns8	976	36	.	.	.
cord-023168-cd7adns8	977	1	244	244	CD
cord-023168-cd7adns8	977	2	Prolongation	prolongation	NN
cord-023168-cd7adns8	977	3	of	of	IN
cord-023168-cd7adns8	977	4	prothrombin	prothrombin	JJ
cord-023168-cd7adns8	977	5	time	time	NN
cord-023168-cd7adns8	977	6	and	and	CC
cord-023168-cd7adns8	977	7	activated	activate	VBD
cord-023168-cd7adns8	977	8	partial	partial	JJ
cord-023168-cd7adns8	977	9	thromboplastin	thromboplastin	NN
cord-023168-cd7adns8	977	10	time	time	NN
cord-023168-cd7adns8	977	11	only	only	RB
cord-023168-cd7adns8	977	12	occur	occur	VBP
cord-023168-cd7adns8	977	13	in	in	IN
cord-023168-cd7adns8	977	14	4	4	CD
cord-023168-cd7adns8	977	15	-	-	SYM
cord-023168-cd7adns8	977	16	8	8	CD
cord-023168-cd7adns8	977	17	%	%	NN
cord-023168-cd7adns8	977	18	of	of	IN
cord-023168-cd7adns8	977	19	patients	patient	NNS
cord-023168-cd7adns8	977	20	with	with	IN
cord-023168-cd7adns8	977	21	P.	P.	NNP
cord-023168-cd7adns8	977	22	falciparum	falciparum	NN
cord-023168-cd7adns8	977	23	infection	infection	NN
cord-023168-cd7adns8	977	24	and	and	CC
cord-023168-cd7adns8	977	25	coagulopathy	coagulopathy	NN
cord-023168-cd7adns8	977	26	does	do	VBZ
cord-023168-cd7adns8	977	27	not	not	RB
cord-023168-cd7adns8	977	28	appear	appear	VB
cord-023168-cd7adns8	977	29	to	to	TO
cord-023168-cd7adns8	977	30	be	be	VB
cord-023168-cd7adns8	977	31	a	a	DT
cord-023168-cd7adns8	977	32	feature	feature	NN
cord-023168-cd7adns8	977	33	of	of	IN
cord-023168-cd7adns8	977	34	P.	p.	NN
cord-023168-cd7adns8	977	35	vivax	vivax	JJ
cord-023168-cd7adns8	977	36	infection	infection	NN
cord-023168-cd7adns8	977	37	.	.	.
cord-023168-cd7adns8	978	1	245	245	CD
cord-023168-cd7adns8	979	1	Since	since	IN
cord-023168-cd7adns8	979	2	coagulation	coagulation	NN
cord-023168-cd7adns8	979	3	factors	factor	NNS
cord-023168-cd7adns8	979	4	need	need	VBP
cord-023168-cd7adns8	979	5	to	to	TO
cord-023168-cd7adns8	979	6	be	be	VB
cord-023168-cd7adns8	979	7	depleted	deplete	VBN
cord-023168-cd7adns8	979	8	to	to	IN
cord-023168-cd7adns8	979	9	less	less	JJR
cord-023168-cd7adns8	979	10	than	than	IN
cord-023168-cd7adns8	979	11	20	20	CD
cord-023168-cd7adns8	979	12	%	%	NN
cord-023168-cd7adns8	979	13	of	of	IN
cord-023168-cd7adns8	979	14	normal	normal	JJ
cord-023168-cd7adns8	979	15	to	to	TO
cord-023168-cd7adns8	979	16	prolong	prolong	VB
cord-023168-cd7adns8	979	17	the	the	DT
cord-023168-cd7adns8	979	18	clotting	clotting	NN
cord-023168-cd7adns8	979	19	times	time	NNS
cord-023168-cd7adns8	979	20	,	,	,
cord-023168-cd7adns8	979	21	these	these	DT
cord-023168-cd7adns8	979	22	tests	test	NNS
cord-023168-cd7adns8	979	23	can	can	MD
cord-023168-cd7adns8	979	24	be	be	VB
cord-023168-cd7adns8	979	25	normal	normal	JJ
cord-023168-cd7adns8	979	26	despite	despite	IN
cord-023168-cd7adns8	979	27	active	active	JJ
cord-023168-cd7adns8	979	28	coagulopathy	coagulopathy	NN
cord-023168-cd7adns8	979	29	.	.	.
cord-023168-cd7adns8	980	1	Management	management	NN
cord-023168-cd7adns8	980	2	of	of	IN
cord-023168-cd7adns8	980	3	coagulopathy	coagulopathy	NN
cord-023168-cd7adns8	980	4	aims	aim	VBZ
cord-023168-cd7adns8	980	5	to	to	TO
cord-023168-cd7adns8	980	6	restore	restore	VB
cord-023168-cd7adns8	980	7	the	the	DT
cord-023168-cd7adns8	980	8	balance	balance	NN
cord-023168-cd7adns8	980	9	between	between	IN
cord-023168-cd7adns8	980	10	pro	pro	JJ
cord-023168-cd7adns8	980	11	-	-	JJ
cord-023168-cd7adns8	980	12	and	and	CC
cord-023168-cd7adns8	980	13	anticoagulant	anticoagulant	JJ
cord-023168-cd7adns8	980	14	processes	process	NNS
cord-023168-cd7adns8	980	15	.	.	.
cord-023168-cd7adns8	981	1	This	this	DT
cord-023168-cd7adns8	981	2	is	be	VBZ
cord-023168-cd7adns8	981	3	complex	complex	JJ
cord-023168-cd7adns8	981	4	and	and	CC
cord-023168-cd7adns8	981	5	requires	require	VBZ
cord-023168-cd7adns8	981	6	input	input	NN
cord-023168-cd7adns8	981	7	from	from	IN
cord-023168-cd7adns8	981	8	a	a	DT
cord-023168-cd7adns8	981	9	coagulation	coagulation	NN
cord-023168-cd7adns8	981	10	specialist	specialist	NN
cord-023168-cd7adns8	981	11	and	and	CC
cord-023168-cd7adns8	981	12	ideally	ideally	RB
cord-023168-cd7adns8	981	13	,	,	,
cord-023168-cd7adns8	981	14	access	access	VBP
cord-023168-cd7adns8	981	15	to	to	IN
cord-023168-cd7adns8	981	16	plasma	plasma	NN
cord-023168-cd7adns8	981	17	,	,	,
cord-023168-cd7adns8	981	18	heparin	heparin	NN
cord-023168-cd7adns8	981	19	and	and	CC
cord-023168-cd7adns8	981	20	factor	factor	NN
cord-023168-cd7adns8	981	21	concentrates	concentrate	VBZ
cord-023168-cd7adns8	981	22	and	and	CC
cord-023168-cd7adns8	981	23	a	a	DT
cord-023168-cd7adns8	981	24	well	well	RB
cord-023168-cd7adns8	981	25	-	-	HYPH
cord-023168-cd7adns8	981	26	equipped	equip	VBN
cord-023168-cd7adns8	981	27	coagulation	coagulation	NN
cord-023168-cd7adns8	981	28	laboratory	laboratory	NN
cord-023168-cd7adns8	981	29	.	.	.
cord-023168-cd7adns8	982	1	ANAEMIA	ANAEMIA	NNP
cord-023168-cd7adns8	982	2	Anaemia	Anaemia	NNP
cord-023168-cd7adns8	982	3	is	be	VBZ
cord-023168-cd7adns8	982	4	very	very	RB
cord-023168-cd7adns8	982	5	common	common	JJ
cord-023168-cd7adns8	982	6	in	in	IN
cord-023168-cd7adns8	982	7	HIV	HIV	NNP
cord-023168-cd7adns8	982	8	-	-	HYPH
cord-023168-cd7adns8	982	9	infected	infect	VBN
cord-023168-cd7adns8	982	10	individuals	individual	NNS
cord-023168-cd7adns8	982	11	occurring	occur	VBG
cord-023168-cd7adns8	982	12	in	in	IN
cord-023168-cd7adns8	982	13	up	up	IN
cord-023168-cd7adns8	982	14	to	to	TO
cord-023168-cd7adns8	982	15	20	20	CD
cord-023168-cd7adns8	982	16	%	%	NN
cord-023168-cd7adns8	982	17	at	at	IN
cord-023168-cd7adns8	982	18	initial	initial	JJ
cord-023168-cd7adns8	982	19	presentation	presentation	NN
cord-023168-cd7adns8	982	20	and	and	CC
cord-023168-cd7adns8	982	21	about	about	RB
cord-023168-cd7adns8	982	22	70	70	CD
cord-023168-cd7adns8	982	23	%	%	NN
cord-023168-cd7adns8	982	24	at	at	IN
cord-023168-cd7adns8	982	25	some	some	DT
cord-023168-cd7adns8	982	26	stage	stage	NN
cord-023168-cd7adns8	982	27	during	during	IN
cord-023168-cd7adns8	982	28	their	-PRON-	PRP$
cord-023168-cd7adns8	982	29	disease	disease	NN
cord-023168-cd7adns8	982	30	.	.	.
cord-023168-cd7adns8	983	1	246	246	CD
cord-023168-cd7adns8	983	2	Thirty	thirty	CD
cord-023168-cd7adns8	983	3	-	-	HYPH
cord-023168-cd7adns8	983	4	seven	seven	CD
cord-023168-cd7adns8	983	5	percent	percent	NN
cord-023168-cd7adns8	983	6	of	of	IN
cord-023168-cd7adns8	983	7	patients	patient	NNS
cord-023168-cd7adns8	983	8	with	with	IN
cord-023168-cd7adns8	983	9	clinical	clinical	JJ
cord-023168-cd7adns8	983	10	AIDS	AIDS	NNP
cord-023168-cd7adns8	983	11	have	have	VBP
cord-023168-cd7adns8	983	12	a	a	DT
cord-023168-cd7adns8	983	13	1-year	1-year	CD
cord-023168-cd7adns8	983	14	incidence	incidence	NN
cord-023168-cd7adns8	983	15	of	of	IN
cord-023168-cd7adns8	983	16	anaemia	anaemia	NN
cord-023168-cd7adns8	983	17	(	(	-LRB-
cord-023168-cd7adns8	984	1	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	984	2	<	<	XX
cord-023168-cd7adns8	984	3	100	100	CD
cord-023168-cd7adns8	984	4	g	g	NN
cord-023168-cd7adns8	984	5	/	/	SYM
cord-023168-cd7adns8	984	6	L	L	NNP
cord-023168-cd7adns8	984	7	)	)	-RRB-
cord-023168-cd7adns8	984	8	246	246	CD
cord-023168-cd7adns8	984	9	and	and	CC
cord-023168-cd7adns8	984	10	high	high	JJ
cord-023168-cd7adns8	984	11	rates	rate	NNS
cord-023168-cd7adns8	984	12	of	of	IN
cord-023168-cd7adns8	984	13	anaemia	anaemia	NN
cord-023168-cd7adns8	984	14	persist	persist	VBP
cord-023168-cd7adns8	984	15	despite	despite	IN
cord-023168-cd7adns8	984	16	combination	combination	NN
cord-023168-cd7adns8	984	17	anti	anti	JJ
cord-023168-cd7adns8	984	18	retroviral	retroviral	JJ
cord-023168-cd7adns8	984	19	treatment	treatment	NN
cord-023168-cd7adns8	984	20	(	(	-LRB-
cord-023168-cd7adns8	984	21	ART	art	NN
cord-023168-cd7adns8	984	22	)	)	-RRB-
cord-023168-cd7adns8	984	23	.	.	.
cord-023168-cd7adns8	985	1	247	247	CD
cord-023168-cd7adns8	985	2	Anaemia	anaemia	NN
cord-023168-cd7adns8	985	3	is	be	VBZ
cord-023168-cd7adns8	985	4	directly	directly	RB
cord-023168-cd7adns8	985	5	related	relate	VBN
cord-023168-cd7adns8	985	6	to	to	IN
cord-023168-cd7adns8	985	7	mortality	mortality	NN
cord-023168-cd7adns8	985	8	in	in	IN
cord-023168-cd7adns8	985	9	HIV	HIV	NNP
cord-023168-cd7adns8	985	10	infection	infection	NN
cord-023168-cd7adns8	985	11	and	and	CC
cord-023168-cd7adns8	985	12	is	be	VBZ
cord-023168-cd7adns8	985	13	independent	independent	JJ
cord-023168-cd7adns8	985	14	of	of	IN
cord-023168-cd7adns8	985	15	other	other	JJ
cord-023168-cd7adns8	985	16	risk	risk	NN
cord-023168-cd7adns8	985	17	factors	factor	NNS
cord-023168-cd7adns8	985	18	including	include	VBG
cord-023168-cd7adns8	985	19	CD4	CD4	NNP
cord-023168-cd7adns8	985	20	count	count	VB
cord-023168-cd7adns8	985	21	.	.	.
cord-023168-cd7adns8	986	1	248	248	CD
cord-023168-cd7adns8	987	1	There	there	EX
cord-023168-cd7adns8	987	2	are	be	VBP
cord-023168-cd7adns8	987	3	multiple	multiple	JJ
cord-023168-cd7adns8	987	4	reasons	reason	NNS
cord-023168-cd7adns8	987	5	for	for	IN
cord-023168-cd7adns8	987	6	anaemia	anaemia	NN
cord-023168-cd7adns8	987	7	in	in	IN
cord-023168-cd7adns8	987	8	HIV	HIV	NNP
cord-023168-cd7adns8	987	9	-	-	HYPH
cord-023168-cd7adns8	987	10	infected	infect	VBN
cord-023168-cd7adns8	987	11	patients	patient	NNS
cord-023168-cd7adns8	987	12	(	(	-LRB-
cord-023168-cd7adns8	987	13	Box	Box	NNP
cord-023168-cd7adns8	987	14	65.17	65.17	CD
cord-023168-cd7adns8	987	15	)	)	-RRB-
cord-023168-cd7adns8	987	16	,	,	,
cord-023168-cd7adns8	987	17	which	which	WDT
cord-023168-cd7adns8	987	18	often	often	RB
cord-023168-cd7adns8	987	19	co	co	VBD
cord-023168-cd7adns8	987	20	-	-	NN
cord-023168-cd7adns8	987	21	exist	exist	VB
cord-023168-cd7adns8	987	22	in	in	IN
cord-023168-cd7adns8	987	23	individual	individual	JJ
cord-023168-cd7adns8	987	24	patients	patient	NNS
cord-023168-cd7adns8	987	25	.	.	.
cord-023168-cd7adns8	988	1	Bone	bone	NN
cord-023168-cd7adns8	988	2	marrow	marrow	NN
cord-023168-cd7adns8	988	3	infection	infection	NN
cord-023168-cd7adns8	988	4	by	by	IN
cord-023168-cd7adns8	988	5	mycobacteria	mycobacterium	NNS
cord-023168-cd7adns8	988	6	species	specie	NNS
cord-023168-cd7adns8	988	7	,	,	,
cord-023168-cd7adns8	988	8	Histoplasma	Histoplasma	NNP
cord-023168-cd7adns8	988	9	,	,	,
cord-023168-cd7adns8	988	10	Cryptococcus	Cryptococcus	NNP
cord-023168-cd7adns8	988	11	and	and	CC
cord-023168-cd7adns8	988	12	Penicillium	Penicillium	NNP
cord-023168-cd7adns8	988	13	marneffei	marneffei	NNP
cord-023168-cd7adns8	988	14	can	can	MD
cord-023168-cd7adns8	988	15	all	all	DT
cord-023168-cd7adns8	988	16	decrease	decrease	VB
cord-023168-cd7adns8	988	17	red	red	JJ
cord-023168-cd7adns8	988	18	cell	cell	NN
cord-023168-cd7adns8	988	19	production	production	NN
cord-023168-cd7adns8	988	20	249	249	CD
cord-023168-cd7adns8	988	21	and	and	CC
cord-023168-cd7adns8	988	22	can	can	MD
cord-023168-cd7adns8	988	23	be	be	VB
cord-023168-cd7adns8	988	24	detected	detect	VBN
cord-023168-cd7adns8	988	25	by	by	IN
cord-023168-cd7adns8	988	26	bone	bone	NN
cord-023168-cd7adns8	988	27	marrow	marrow	NN
cord-023168-cd7adns8	988	28	examination	examination	NN
cord-023168-cd7adns8	988	29	and	and	CC
cord-023168-cd7adns8	988	30	cultures	culture	NNS
cord-023168-cd7adns8	988	31	.	.	.
cord-023168-cd7adns8	989	1	Parvovirus	parvovirus	NN
cord-023168-cd7adns8	989	2	has	have	VBZ
cord-023168-cd7adns8	989	3	a	a	DT
cord-023168-cd7adns8	989	4	predilection	predilection	NN
cord-023168-cd7adns8	989	5	for	for	IN
cord-023168-cd7adns8	989	6	the	the	DT
cord-023168-cd7adns8	989	7	erythroid	erythroid	JJ
cord-023168-cd7adns8	989	8	progenitor	progenitor	NN
cord-023168-cd7adns8	989	9	cells	cell	NNS
cord-023168-cd7adns8	989	10	and	and	CC
cord-023168-cd7adns8	989	11	can	can	MD
cord-023168-cd7adns8	989	12	cause	cause	VB
cord-023168-cd7adns8	989	13	severe	severe	JJ
cord-023168-cd7adns8	989	14	anaemia	anaemia	NN
cord-023168-cd7adns8	989	15	in	in	IN
cord-023168-cd7adns8	989	16	HIV	HIV	NNP
cord-023168-cd7adns8	989	17	-	-	HYPH
cord-023168-cd7adns8	989	18	infected	infect	VBN
cord-023168-cd7adns8	989	19	patients	patient	NNS
cord-023168-cd7adns8	989	20	.	.	.
cord-023168-cd7adns8	990	1	Serological	serological	JJ
cord-023168-cd7adns8	990	2	tests	test	NNS
cord-023168-cd7adns8	990	3	for	for	IN
cord-023168-cd7adns8	990	4	parvovirus	parvovirus	NN
cord-023168-cd7adns8	990	5	are	be	VBP
cord-023168-cd7adns8	990	6	unhelpful	unhelpful	JJ
cord-023168-cd7adns8	990	7	in	in	IN
cord-023168-cd7adns8	990	8	HIVinfected	hivinfecte	VBN
cord-023168-cd7adns8	990	9	patients	patient	NNS
cord-023168-cd7adns8	990	10	and	and	CC
cord-023168-cd7adns8	990	11	viral	viral	JJ
cord-023168-cd7adns8	990	12	polymerase	polymerase	NN
cord-023168-cd7adns8	990	13	chain	chain	NN
cord-023168-cd7adns8	990	14	reaction	reaction	NN
cord-023168-cd7adns8	990	15	is	be	VBZ
cord-023168-cd7adns8	990	16	needed	need	VBN
cord-023168-cd7adns8	990	17	to	to	TO
cord-023168-cd7adns8	990	18	confirm	confirm	VB
cord-023168-cd7adns8	990	19	the	the	DT
cord-023168-cd7adns8	990	20	diagnosis	diagnosis	NN
cord-023168-cd7adns8	990	21	.	.	.
cord-023168-cd7adns8	991	1	250	250	CD
cord-023168-cd7adns8	992	1	The	the	DT
cord-023168-cd7adns8	992	2	likelihood	likelihood	NN
cord-023168-cd7adns8	992	3	of	of	IN
cord-023168-cd7adns8	992	4	parvovirusinduced	parvovirusinduced	JJ
cord-023168-cd7adns8	992	5	anaemia	anaemia	NN
cord-023168-cd7adns8	992	6	increases	increase	VBZ
cord-023168-cd7adns8	992	7	with	with	IN
cord-023168-cd7adns8	992	8	the	the	DT
cord-023168-cd7adns8	992	9	severity	severity	NN
cord-023168-cd7adns8	992	10	of	of	IN
cord-023168-cd7adns8	992	11	anaemia	anaemia	NN
cord-023168-cd7adns8	992	12	and	and	CC
cord-023168-cd7adns8	992	13	has	have	VBZ
cord-023168-cd7adns8	992	14	been	be	VBN
cord-023168-cd7adns8	992	15	found	find	VBN
cord-023168-cd7adns8	992	16	in	in	IN
cord-023168-cd7adns8	992	17	31	31	CD
cord-023168-cd7adns8	992	18	%	%	NN
cord-023168-cd7adns8	992	19	of	of	IN
cord-023168-cd7adns8	992	20	individuals	individual	NNS
cord-023168-cd7adns8	992	21	with	with	IN
cord-023168-cd7adns8	992	22	HIV	HIV	NNP
cord-023168-cd7adns8	992	23	and	and	CC
cord-023168-cd7adns8	992	24	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	992	25	less	less	JJR
cord-023168-cd7adns8	992	26	than	than	IN
cord-023168-cd7adns8	992	27	70	70	CD
cord-023168-cd7adns8	992	28	g	g	NN
cord-023168-cd7adns8	992	29	/	/	SYM
cord-023168-cd7adns8	992	30	L.	L.	NNP
cord-023168-cd7adns8	992	31	251	251	CD
cord-023168-cd7adns8	992	32	Haemophagocytosis	Haemophagocytosis	NNP
cord-023168-cd7adns8	992	33	occurs	occur	VBZ
cord-023168-cd7adns8	992	34	in	in	IN
cord-023168-cd7adns8	992	35	HIV	HIV	NNP
cord-023168-cd7adns8	992	36	infections	infection	NNS
cord-023168-cd7adns8	992	37	and	and	CC
cord-023168-cd7adns8	992	38	may	may	MD
cord-023168-cd7adns8	992	39	be	be	VB
cord-023168-cd7adns8	992	40	secondary	secondary	JJ
cord-023168-cd7adns8	992	41	to	to	TO
cord-023168-cd7adns8	992	42	co	co	VB
cord-023168-cd7adns8	992	43	-	-	VB
cord-023168-cd7adns8	992	44	infection	infection	NN
cord-023168-cd7adns8	992	45	with	with	IN
cord-023168-cd7adns8	992	46	mycobacteria	mycobacterium	NNS
cord-023168-cd7adns8	992	47	,	,	,
cord-023168-cd7adns8	992	48	cytomegalovirus	cytomegalovirus	NNP
cord-023168-cd7adns8	992	49	,	,	,
cord-023168-cd7adns8	992	50	Epstein	Epstein	NNP
cord-023168-cd7adns8	992	51	-	-	HYPH
cord-023168-cd7adns8	992	52	Barr	Barr	NNP
cord-023168-cd7adns8	992	53	or	or	CC
cord-023168-cd7adns8	992	54	other	other	JJ
cord-023168-cd7adns8	992	55	herpesviruses	herpesviruse	NNS
cord-023168-cd7adns8	992	56	.	.	.
cord-023168-cd7adns8	993	1	Poor	poor	JJ
cord-023168-cd7adns8	993	2	nutrition	nutrition	NN
cord-023168-cd7adns8	993	3	due	due	IN
cord-023168-cd7adns8	993	4	to	to	IN
cord-023168-cd7adns8	993	5	socioeconomic	socioeconomic	JJ
cord-023168-cd7adns8	993	6	reasons	reason	NNS
cord-023168-cd7adns8	993	7	,	,	,
cord-023168-cd7adns8	993	8	HIV	HIV	NNP
cord-023168-cd7adns8	993	9	-	-	HYPH
cord-023168-cd7adns8	993	10	related	relate	VBN
cord-023168-cd7adns8	993	11	anorexia	anorexia	NN
cord-023168-cd7adns8	993	12	,	,	,
cord-023168-cd7adns8	993	13	malabsorption	malabsorption	NN
cord-023168-cd7adns8	993	14	from	from	IN
cord-023168-cd7adns8	993	15	conditions	condition	NNS
cord-023168-cd7adns8	993	16	affecting	affect	VBG
cord-023168-cd7adns8	993	17	the	the	DT
cord-023168-cd7adns8	993	18	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	993	19	tract	tract	NN
cord-023168-cd7adns8	993	20	,	,	,
cord-023168-cd7adns8	993	21	and	and	CC
cord-023168-cd7adns8	993	22	achlorhydria	achlorhydria	NNP
cord-023168-cd7adns8	993	23	may	may	MD
cord-023168-cd7adns8	993	24	contribute	contribute	VB
cord-023168-cd7adns8	993	25	to	to	IN
cord-023168-cd7adns8	993	26	anaemia	anaemia	NN
cord-023168-cd7adns8	993	27	.	.	.
cord-023168-cd7adns8	994	1	Haemolytic	haemolytic	JJ
cord-023168-cd7adns8	994	2	anaemia	anaemia	NN
cord-023168-cd7adns8	994	3	occurs	occur	VBZ
cord-023168-cd7adns8	994	4	secondary	secondary	JJ
cord-023168-cd7adns8	994	5	to	to	IN
cord-023168-cd7adns8	994	6	drugs	drug	NNS
cord-023168-cd7adns8	994	7	or	or	CC
cord-023168-cd7adns8	994	8	concomitant	concomitant	JJ
cord-023168-cd7adns8	994	9	glucose-6	glucose-6	NN
cord-023168-cd7adns8	994	10	phosphate	phosphate	NN
cord-023168-cd7adns8	994	11	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	994	12	deficiency	deficiency	NN
cord-023168-cd7adns8	994	13	and	and	CC
cord-023168-cd7adns8	994	14	because	because	IN
cord-023168-cd7adns8	994	15	reticulocytopenia	reticulocytopenia	NNP
cord-023168-cd7adns8	994	16	is	be	VBZ
cord-023168-cd7adns8	994	17	common	common	JJ
cord-023168-cd7adns8	994	18	in	in	IN
cord-023168-cd7adns8	994	19	those	those	DT
cord-023168-cd7adns8	994	20	with	with	IN
cord-023168-cd7adns8	994	21	HIV	HIV	NNP
cord-023168-cd7adns8	994	22	infection	infection	NN
cord-023168-cd7adns8	994	23	,	,	,
cord-023168-cd7adns8	994	24	reticulocyte	reticulocyte	NNP
cord-023168-cd7adns8	994	25	counts	count	NNS
cord-023168-cd7adns8	994	26	can	can	MD
cord-023168-cd7adns8	994	27	not	not	RB
cord-023168-cd7adns8	994	28	be	be	VB
cord-023168-cd7adns8	994	29	used	use	VBN
cord-023168-cd7adns8	994	30	to	to	TO
cord-023168-cd7adns8	994	31	exclude	exclude	VB
cord-023168-cd7adns8	994	32	haemolysis	haemolysis	NN
cord-023168-cd7adns8	994	33	.	.	.
cord-023168-cd7adns8	995	1	Although	although	IN
cord-023168-cd7adns8	995	2	the	the	DT
cord-023168-cd7adns8	995	3	direct	direct	JJ
cord-023168-cd7adns8	995	4	Coombs	Coombs	NNP
cord-023168-cd7adns8	995	5	test	test	NN
cord-023168-cd7adns8	995	6	may	may	MD
cord-023168-cd7adns8	995	7	be	be	VB
cord-023168-cd7adns8	995	8	positive	positive	JJ
cord-023168-cd7adns8	995	9	in	in	IN
cord-023168-cd7adns8	995	10	patients	patient	NNS
cord-023168-cd7adns8	995	11	with	with	IN
cord-023168-cd7adns8	995	12	HIV	HIV	NNP
cord-023168-cd7adns8	995	13	infection	infection	NN
cord-023168-cd7adns8	995	14	,	,	,
cord-023168-cd7adns8	995	15	autoimmune	autoimmune	NNP
cord-023168-cd7adns8	995	16	haemolysis	haemolysis	NNP
cord-023168-cd7adns8	995	17	is	be	VBZ
cord-023168-cd7adns8	995	18	not	not	RB
cord-023168-cd7adns8	995	19	a	a	DT
cord-023168-cd7adns8	995	20	common	common	JJ
cord-023168-cd7adns8	995	21	cause	cause	NN
cord-023168-cd7adns8	995	22	of	of	IN
cord-023168-cd7adns8	995	23	anaemia	anaemia	NN
cord-023168-cd7adns8	995	24	.	.	.
cord-023168-cd7adns8	996	1	A	a	DT
cord-023168-cd7adns8	996	2	reduction	reduction	NN
cord-023168-cd7adns8	996	3	in	in	IN
cord-023168-cd7adns8	996	4	red	red	JJ
cord-023168-cd7adns8	996	5	cell	cell	NN
cord-023168-cd7adns8	996	6	precursors	precursor	NNS
cord-023168-cd7adns8	996	7	has	have	VBZ
cord-023168-cd7adns8	996	8	also	also	RB
cord-023168-cd7adns8	996	9	been	be	VBN
cord-023168-cd7adns8	996	10	noted	note	VBN
cord-023168-cd7adns8	996	11	in	in	IN
cord-023168-cd7adns8	996	12	children	child	NNS
cord-023168-cd7adns8	996	13	in	in	IN
cord-023168-cd7adns8	996	14	Africa	Africa	NNP
cord-023168-cd7adns8	996	15	with	with	IN
cord-023168-cd7adns8	996	16	severe	severe	JJ
cord-023168-cd7adns8	996	17	anaemia	anaemia	NN
cord-023168-cd7adns8	996	18	.	.	.
cord-023168-cd7adns8	997	1	252	252	CD
cord-023168-cd7adns8	997	2	Treatment	Treatment	NNP
cord-023168-cd7adns8	997	3	of	of	IN
cord-023168-cd7adns8	997	4	HIV	HIV	NNP
cord-023168-cd7adns8	997	5	-	-	HYPH
cord-023168-cd7adns8	997	6	related	relate	VBN
cord-023168-cd7adns8	997	7	anaemia	anaemia	NN
cord-023168-cd7adns8	997	8	should	should	MD
cord-023168-cd7adns8	997	9	focus	focus	VB
cord-023168-cd7adns8	997	10	on	on	IN
cord-023168-cd7adns8	997	11	starting	start	VBG
cord-023168-cd7adns8	997	12	ART	art	NN
cord-023168-cd7adns8	997	13	and	and	CC
cord-023168-cd7adns8	997	14	eliminating	eliminate	VBG
cord-023168-cd7adns8	997	15	any	any	DT
cord-023168-cd7adns8	997	16	other	other	JJ
cord-023168-cd7adns8	997	17	factors	factor	NNS
cord-023168-cd7adns8	997	18	,	,	,
cord-023168-cd7adns8	997	19	such	such	JJ
cord-023168-cd7adns8	997	20	as	as	IN
cord-023168-cd7adns8	997	21	infections	infection	NNS
cord-023168-cd7adns8	997	22	or	or	CC
cord-023168-cd7adns8	997	23	vitamin	vitamin	NN
cord-023168-cd7adns8	997	24	deficiencies	deficiency	NNS
cord-023168-cd7adns8	997	25	,	,	,
cord-023168-cd7adns8	997	26	which	which	WDT
cord-023168-cd7adns8	997	27	may	may	MD
cord-023168-cd7adns8	997	28	contribute	contribute	VB
cord-023168-cd7adns8	997	29	to	to	IN
cord-023168-cd7adns8	997	30	the	the	DT
cord-023168-cd7adns8	997	31	anaemia	anaemia	NN
cord-023168-cd7adns8	997	32	.	.	.
cord-023168-cd7adns8	998	1	In	in	IN
cord-023168-cd7adns8	998	2	wealthy	wealthy	JJ
cord-023168-cd7adns8	998	3	countries	country	NNS
cord-023168-cd7adns8	998	4	ART	art	NN
cord-023168-cd7adns8	998	5	has	have	VBZ
cord-023168-cd7adns8	998	6	been	be	VBN
cord-023168-cd7adns8	998	7	shown	show	VBN
cord-023168-cd7adns8	998	8	to	to	TO
cord-023168-cd7adns8	998	9	reduce	reduce	VB
cord-023168-cd7adns8	998	10	anaemia	anaemia	NN
cord-023168-cd7adns8	998	11	prevalence	prevalence	NN
cord-023168-cd7adns8	998	12	from	from	IN
cord-023168-cd7adns8	998	13	65	65	CD
cord-023168-cd7adns8	998	14	%	%	NN
cord-023168-cd7adns8	998	15	to	to	IN
cord-023168-cd7adns8	998	16	53	53	CD
cord-023168-cd7adns8	998	17	%	%	NN
cord-023168-cd7adns8	998	18	within	within	IN
cord-023168-cd7adns8	998	19	6	6	CD
cord-023168-cd7adns8	998	20	months	month	NNS
cord-023168-cd7adns8	998	21	of	of	IN
cord-023168-cd7adns8	998	22	starting	start	VBG
cord-023168-cd7adns8	998	23	treatment	treatment	NN
cord-023168-cd7adns8	998	24	,	,	,
cord-023168-cd7adns8	998	25	 	 	_SP
cord-023168-cd7adns8	998	26	Non	Non	NNP
cord-023168-cd7adns8	998	27	-	-	NNP
cord-023168-cd7adns8	998	28	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	998	29	's	's	POS
cord-023168-cd7adns8	998	30	lymphoma	lymphoma	NN
cord-023168-cd7adns8	998	31	(	(	-LRB-
cord-023168-cd7adns8	998	32	NHL	NHL	NNP
cord-023168-cd7adns8	998	33	)	)	-RRB-
cord-023168-cd7adns8	998	34	was	be	VBD
cord-023168-cd7adns8	998	35	noted	note	VBN
cord-023168-cd7adns8	998	36	to	to	TO
cord-023168-cd7adns8	998	37	be	be	VB
cord-023168-cd7adns8	998	38	associated	associate	VBN
cord-023168-cd7adns8	998	39	with	with	IN
cord-023168-cd7adns8	998	40	HIV	HIV	NNP
cord-023168-cd7adns8	998	41	infection	infection	NN
cord-023168-cd7adns8	998	42	early	early	RB
cord-023168-cd7adns8	998	43	in	in	IN
cord-023168-cd7adns8	998	44	the	the	DT
cord-023168-cd7adns8	998	45	epidemic	epidemic	NN
cord-023168-cd7adns8	998	46	and	and	CC
cord-023168-cd7adns8	998	47	is	be	VBZ
cord-023168-cd7adns8	998	48	an	an	DT
cord-023168-cd7adns8	998	49	AIDSdefining	aidsdefine	VBG
cord-023168-cd7adns8	998	50	illness	illness	NN
cord-023168-cd7adns8	998	51	.	.	.
cord-023168-cd7adns8	999	1	270	270	CD
cord-023168-cd7adns8	1000	1	The	the	DT
cord-023168-cd7adns8	1000	2	incidence	incidence	NN
cord-023168-cd7adns8	1000	3	of	of	IN
cord-023168-cd7adns8	1000	4	NHL	NHL	NNP
cord-023168-cd7adns8	1000	5	is	be	VBZ
cord-023168-cd7adns8	1000	6	up	up	IN
cord-023168-cd7adns8	1000	7	to	to	TO
cord-023168-cd7adns8	1000	8	200	200	CD
cord-023168-cd7adns8	1000	9	times	time	NNS
cord-023168-cd7adns8	1000	10	greater	great	JJR
cord-023168-cd7adns8	1000	11	in	in	IN
cord-023168-cd7adns8	1000	12	HIV	HIV	NNP
cord-023168-cd7adns8	1000	13	-	-	HYPH
cord-023168-cd7adns8	1000	14	infected	infect	VBN
cord-023168-cd7adns8	1000	15	adults	adult	NNS
cord-023168-cd7adns8	1000	16	than	than	IN
cord-023168-cd7adns8	1000	17	in	in	IN
cord-023168-cd7adns8	1000	18	those	those	DT
cord-023168-cd7adns8	1000	19	who	who	WP
cord-023168-cd7adns8	1000	20	are	be	VBP
cord-023168-cd7adns8	1000	21	not	not	RB
cord-023168-cd7adns8	1000	22	infected	infect	VBN
cord-023168-cd7adns8	1000	23	,	,	,
cord-023168-cd7adns8	1000	24	and	and	CC
cord-023168-cd7adns8	1000	25	it	-PRON-	PRP
cord-023168-cd7adns8	1000	26	is	be	VBZ
cord-023168-cd7adns8	1000	27	responsible	responsible	JJ
cord-023168-cd7adns8	1000	28	for	for	IN
cord-023168-cd7adns8	1000	29	nearly	nearly	RB
cord-023168-cd7adns8	1000	30	one	one	CD
cord-023168-cd7adns8	1000	31	-	-	HYPH
cord-023168-cd7adns8	1000	32	sixth	sixth	NN
cord-023168-cd7adns8	1000	33	of	of	IN
cord-023168-cd7adns8	1000	34	the	the	DT
cord-023168-cd7adns8	1000	35	deaths	death	NNS
cord-023168-cd7adns8	1000	36	attributable	attributable	JJ
cord-023168-cd7adns8	1000	37	to	to	IN
cord-023168-cd7adns8	1000	38	AIDS	AIDS	NNP
cord-023168-cd7adns8	1000	39	.	.	.
cord-023168-cd7adns8	1001	1	Since	since	IN
cord-023168-cd7adns8	1001	2	the	the	DT
cord-023168-cd7adns8	1001	3	introduction	introduction	NN
cord-023168-cd7adns8	1001	4	of	of	IN
cord-023168-cd7adns8	1001	5	HAART	HAART	NNP
cord-023168-cd7adns8	1001	6	,	,	,
cord-023168-cd7adns8	1001	7	the	the	DT
cord-023168-cd7adns8	1001	8	incidence	incidence	NN
cord-023168-cd7adns8	1001	9	of	of	IN
cord-023168-cd7adns8	1001	10	all	all	DT
cord-023168-cd7adns8	1001	11	types	type	NNS
cord-023168-cd7adns8	1001	12	of	of	IN
cord-023168-cd7adns8	1001	13	NHL	NHL	NNP
cord-023168-cd7adns8	1001	14	has	have	VBZ
cord-023168-cd7adns8	1001	15	decreased	decrease	VBN
cord-023168-cd7adns8	1001	16	by	by	IN
cord-023168-cd7adns8	1001	17	approximately	approximately	RB
cord-023168-cd7adns8	1001	18	30	30	CD
cord-023168-cd7adns8	1001	19	-	-	SYM
cord-023168-cd7adns8	1001	20	50	50	CD
cord-023168-cd7adns8	1001	21	%	%	NN
cord-023168-cd7adns8	1001	22	271	271	CD
cord-023168-cd7adns8	1001	23	,	,	,
cord-023168-cd7adns8	1001	24	272	272	CD
cord-023168-cd7adns8	1001	25	and	and	CC
cord-023168-cd7adns8	1001	26	the	the	DT
cord-023168-cd7adns8	1001	27	outcome	outcome	NN
cord-023168-cd7adns8	1001	28	of	of	IN
cord-023168-cd7adns8	1001	29	HIV	HIV	NNP
cord-023168-cd7adns8	1001	30	-	-	HYPH
cord-023168-cd7adns8	1001	31	infected	infect	VBN
cord-023168-cd7adns8	1001	32	patients	patient	NNS
cord-023168-cd7adns8	1001	33	with	with	IN
cord-023168-cd7adns8	1001	34	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1001	35	has	have	VBZ
cord-023168-cd7adns8	1001	36	improved	improve	VBN
cord-023168-cd7adns8	1001	37	.	.	.
cord-023168-cd7adns8	1002	1	In	in	IN
cord-023168-cd7adns8	1002	2	the	the	DT
cord-023168-cd7adns8	1002	3	setting	setting	NN
cord-023168-cd7adns8	1002	4	of	of	IN
cord-023168-cd7adns8	1002	5	clinical	clinical	JJ
cord-023168-cd7adns8	1002	6	trials	trial	NNS
cord-023168-cd7adns8	1002	7	,	,	,
cord-023168-cd7adns8	1002	8	the	the	DT
cord-023168-cd7adns8	1002	9	60	60	CD
cord-023168-cd7adns8	1002	10	%	%	NN
cord-023168-cd7adns8	1002	11	1-year	1-year	CD
cord-023168-cd7adns8	1002	12	survival	survival	NN
cord-023168-cd7adns8	1002	13	rate	rate	NN
cord-023168-cd7adns8	1002	14	is	be	VBZ
cord-023168-cd7adns8	1002	15	comparable	comparable	JJ
cord-023168-cd7adns8	1002	16	to	to	IN
cord-023168-cd7adns8	1002	17	those	those	DT
cord-023168-cd7adns8	1002	18	without	without	IN
cord-023168-cd7adns8	1002	19	HIV	HIV	NNP
cord-023168-cd7adns8	1002	20	infection	infection	NN
cord-023168-cd7adns8	1002	21	.	.	.
cord-023168-cd7adns8	1003	1	273	273	CD
cord-023168-cd7adns8	1004	1	The	the	DT
cord-023168-cd7adns8	1004	2	incidence	incidence	NN
cord-023168-cd7adns8	1004	3	of	of	IN
cord-023168-cd7adns8	1004	4	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1004	5	's	's	POS
cord-023168-cd7adns8	1004	6	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1004	7	has	have	VBZ
cord-023168-cd7adns8	1004	8	increased	increase	VBN
cord-023168-cd7adns8	1004	9	in	in	IN
cord-023168-cd7adns8	1004	10	the	the	DT
cord-023168-cd7adns8	1004	11	post	post	JJ
cord-023168-cd7adns8	1004	12	-	-	JJ
cord-023168-cd7adns8	1004	13	HAART	haart	JJ
cord-023168-cd7adns8	1004	14	era	era	NN
cord-023168-cd7adns8	1004	15	,	,	,
cord-023168-cd7adns8	1004	16	possibly	possibly	RB
cord-023168-cd7adns8	1004	17	due	due	JJ
cord-023168-cd7adns8	1004	18	to	to	IN
cord-023168-cd7adns8	1004	19	immune	immune	JJ
cord-023168-cd7adns8	1004	20	reconstitution	reconstitution	NN
cord-023168-cd7adns8	1004	21	and	and	CC
cord-023168-cd7adns8	1004	22	increased	increase	VBN
cord-023168-cd7adns8	1004	23	CD4	CD4	NNP
cord-023168-cd7adns8	1004	24	cells	cell	NNS
cord-023168-cd7adns8	1004	25	.	.	.
cord-023168-cd7adns8	1005	1	274	274	CD
cord-023168-cd7adns8	1005	2	,	,	,
cord-023168-cd7adns8	1005	3	275	275	CD
cord-023168-cd7adns8	1005	4	Evidence	evidence	NN
cord-023168-cd7adns8	1005	5	of	of	IN
cord-023168-cd7adns8	1005	6	Epstein	Epstein	NNP
cord-023168-cd7adns8	1005	7	-	-	HYPH
cord-023168-cd7adns8	1005	8	Barr	Barr	NNP
cord-023168-cd7adns8	1005	9	virus	virus	NN
cord-023168-cd7adns8	1005	10	(	(	-LRB-
cord-023168-cd7adns8	1005	11	EBV	EBV	NNP
cord-023168-cd7adns8	1005	12	)	)	-RRB-
cord-023168-cd7adns8	1005	13	infection	infection	NN
cord-023168-cd7adns8	1005	14	can	can	MD
cord-023168-cd7adns8	1005	15	be	be	VB
cord-023168-cd7adns8	1005	16	found	find	VBN
cord-023168-cd7adns8	1005	17	in	in	IN
cord-023168-cd7adns8	1005	18	virtually	virtually	RB
cord-023168-cd7adns8	1005	19	all	all	DT
cord-023168-cd7adns8	1005	20	cases	case	NNS
cord-023168-cd7adns8	1005	21	of	of	IN
cord-023168-cd7adns8	1005	22	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1005	23	's	's	POS
cord-023168-cd7adns8	1005	24	disease	disease	NN
cord-023168-cd7adns8	1005	25	.	.	.
cord-023168-cd7adns8	1006	1	276	276	CD
cord-023168-cd7adns8	1006	2	HIV	HIV	NNP
cord-023168-cd7adns8	1006	3	-	-	HYPH
cord-023168-cd7adns8	1006	4	related	relate	VBN
cord-023168-cd7adns8	1006	5	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1006	6	(	(	-LRB-
cord-023168-cd7adns8	1006	7	Box	Box	NNP
cord-023168-cd7adns8	1006	8	65.18	65.18	CD
cord-023168-cd7adns8	1006	9	)	)	-RRB-
cord-023168-cd7adns8	1006	10	277	277	CD
cord-023168-cd7adns8	1006	11	(	(	-LRB-
cord-023168-cd7adns8	1006	12	see	see	VB
cord-023168-cd7adns8	1006	13	also	also	RB
cord-023168-cd7adns8	1006	14	Lymphomas	Lymphomas	NNP
cord-023168-cd7adns8	1006	15	,	,	,
cord-023168-cd7adns8	1006	16	below	below	IN
cord-023168-cd7adns8	1006	17	)	)	-RRB-
cord-023168-cd7adns8	1006	18	,	,	,
cord-023168-cd7adns8	1006	19	are	be	VBP
cord-023168-cd7adns8	1006	20	broadly	broadly	RB
cord-023168-cd7adns8	1006	21	divided	divide	VBN
cord-023168-cd7adns8	1006	22	into	into	IN
cord-023168-cd7adns8	1006	23	systemic	systemic	JJ
cord-023168-cd7adns8	1006	24	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1006	25	(	(	-LRB-
cord-023168-cd7adns8	1006	26	80	80	CD
cord-023168-cd7adns8	1006	27	%	%	NN
cord-023168-cd7adns8	1006	28	)	)	-RRB-
cord-023168-cd7adns8	1006	29	and	and	CC
cord-023168-cd7adns8	1006	30	primary	primary	JJ
cord-023168-cd7adns8	1006	31	central	central	JJ
cord-023168-cd7adns8	1006	32	nervous	nervous	JJ
cord-023168-cd7adns8	1006	33	system	system	NN
cord-023168-cd7adns8	1006	34	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1006	35	.	.	.
cord-023168-cd7adns8	1007	1	278	278	CD
cord-023168-cd7adns8	1008	1	The	the	DT
cord-023168-cd7adns8	1008	2	incidence	incidence	NN
cord-023168-cd7adns8	1008	3	of	of	IN
cord-023168-cd7adns8	1008	4	highly	highly	RB
cord-023168-cd7adns8	1008	5	aggressive	aggressive	JJ
cord-023168-cd7adns8	1008	6	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1008	7	,	,	,
cord-023168-cd7adns8	1008	8	either	either	CC
cord-023168-cd7adns8	1008	9	Burkitt	Burkitt	NNP
cord-023168-cd7adns8	1008	10	's	's	POS
cord-023168-cd7adns8	1008	11	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1008	12	(	(	-LRB-
cord-023168-cd7adns8	1008	13	approx	approx	NN
cord-023168-cd7adns8	1008	14	.	.	.
cord-023168-cd7adns8	1008	15	25	25	CD
cord-023168-cd7adns8	1008	16	%	%	NN
cord-023168-cd7adns8	1008	17	)	)	-RRB-
cord-023168-cd7adns8	1008	18	or	or	CC
cord-023168-cd7adns8	1008	19	diffuse	diffuse	VB
cord-023168-cd7adns8	1008	20	large	large	JJ
cord-023168-cd7adns8	1008	21	B	b	NN
cord-023168-cd7adns8	1008	22	-	-	HYPH
cord-023168-cd7adns8	1008	23	cell	cell	NN
cord-023168-cd7adns8	1008	24	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1008	25	(	(	-LRB-
cord-023168-cd7adns8	1008	26	approx	approx	NN
cord-023168-cd7adns8	1008	27	.	.	.
cord-023168-cd7adns8	1008	28	75	75	CD
cord-023168-cd7adns8	1008	29	%	%	NN
cord-023168-cd7adns8	1008	30	)	)	-RRB-
cord-023168-cd7adns8	1008	31	,	,	,
cord-023168-cd7adns8	1008	32	is	be	VBZ
cord-023168-cd7adns8	1008	33	much	much	RB
cord-023168-cd7adns8	1008	34	higher	high	JJR
cord-023168-cd7adns8	1008	35	in	in	IN
cord-023168-cd7adns8	1008	36	HIV	HIV	NNP
cord-023168-cd7adns8	1008	37	-	-	HYPH
cord-023168-cd7adns8	1008	38	infected	infect	VBN
cord-023168-cd7adns8	1008	39	patients	patient	NNS
cord-023168-cd7adns8	1008	40	than	than	IN
cord-023168-cd7adns8	1008	41	in	in	IN
cord-023168-cd7adns8	1008	42	those	those	DT
cord-023168-cd7adns8	1008	43	without	without	IN
cord-023168-cd7adns8	1008	44	infection	infection	NN
cord-023168-cd7adns8	1008	45	.	.	.
cord-023168-cd7adns8	1009	1	279	279	CD
cord-023168-cd7adns8	1010	1	Although	although	IN
cord-023168-cd7adns8	1010	2	T	t	NN
cord-023168-cd7adns8	1010	3	-	-	HYPH
cord-023168-cd7adns8	1010	4	cell	cell	NN
cord-023168-cd7adns8	1010	5	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1010	6	are	be	VBP
cord-023168-cd7adns8	1010	7	uncommon	uncommon	JJ
cord-023168-cd7adns8	1010	8	in	in	IN
cord-023168-cd7adns8	1010	9	HIV	HIV	NNP
cord-023168-cd7adns8	1010	10	disease	disease	NN
cord-023168-cd7adns8	1010	11	(	(	-LRB-
cord-023168-cd7adns8	1010	12	1	1	CD
cord-023168-cd7adns8	1010	13	%	%	NN
cord-023168-cd7adns8	1010	14	)	)	-RRB-
cord-023168-cd7adns8	1010	15	,	,	,
cord-023168-cd7adns8	1010	16	there	there	EX
cord-023168-cd7adns8	1010	17	has	have	VBZ
cord-023168-cd7adns8	1010	18	been	be	VBN
cord-023168-cd7adns8	1010	19	an	an	DT
cord-023168-cd7adns8	1010	20	increase	increase	NN
cord-023168-cd7adns8	1010	21	in	in	IN
cord-023168-cd7adns8	1010	22	recent	recent	JJ
cord-023168-cd7adns8	1010	23	years	year	NNS
cord-023168-cd7adns8	1010	24	.	.	.
cord-023168-cd7adns8	1011	1	The	the	DT
cord-023168-cd7adns8	1011	2	incidence	incidence	NN
cord-023168-cd7adns8	1011	3	of	of	IN
cord-023168-cd7adns8	1011	4	primary	primary	JJ
cord-023168-cd7adns8	1011	5	central	central	JJ
cord-023168-cd7adns8	1011	6	nervous	nervous	JJ
cord-023168-cd7adns8	1011	7	system	system	NN
cord-023168-cd7adns8	1011	8	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1011	9	in	in	IN
cord-023168-cd7adns8	1011	10	HIV	HIV	NNP
cord-023168-cd7adns8	1011	11	-	-	HYPH
cord-023168-cd7adns8	1011	12	affected	affect	VBN
cord-023168-cd7adns8	1011	13	individuals	individual	NNS
cord-023168-cd7adns8	1011	14	is	be	VBZ
cord-023168-cd7adns8	1011	15	2	2	CD
cord-023168-cd7adns8	1011	16	-	-	SYM
cord-023168-cd7adns8	1011	17	6	6	CD
cord-023168-cd7adns8	1011	18	%	%	NN
cord-023168-cd7adns8	1011	19	and	and	CC
cord-023168-cd7adns8	1011	20	it	-PRON-	PRP
cord-023168-cd7adns8	1011	21	is	be	VBZ
cord-023168-cd7adns8	1011	22	1000	1000	CD
cord-023168-cd7adns8	1011	23	times	time	NNS
cord-023168-cd7adns8	1011	24	more	more	RBR
cord-023168-cd7adns8	1011	25	common	common	JJ
cord-023168-cd7adns8	1011	26	than	than	IN
cord-023168-cd7adns8	1011	27	in	in	IN
cord-023168-cd7adns8	1011	28	the	the	DT
cord-023168-cd7adns8	1011	29	general	general	JJ
cord-023168-cd7adns8	1011	30	population	population	NN
cord-023168-cd7adns8	1011	31	.	.	.
cord-023168-cd7adns8	1012	1	280	280	CD
cord-023168-cd7adns8	1013	1	The	the	DT
cord-023168-cd7adns8	1013	2	pathogenesis	pathogenesis	NN
cord-023168-cd7adns8	1013	3	of	of	IN
cord-023168-cd7adns8	1013	4	NHL	NHL	NNP
cord-023168-cd7adns8	1013	5	in	in	IN
cord-023168-cd7adns8	1013	6	HIV	HIV	NNP
cord-023168-cd7adns8	1013	7	infection	infection	NN
cord-023168-cd7adns8	1013	8	is	be	VBZ
cord-023168-cd7adns8	1013	9	related	relate	VBN
cord-023168-cd7adns8	1013	10	to	to	IN
cord-023168-cd7adns8	1013	11	the	the	DT
cord-023168-cd7adns8	1013	12	inadequate	inadequate	JJ
cord-023168-cd7adns8	1013	13	host	host	NN
cord-023168-cd7adns8	1013	14	immune	immune	JJ
cord-023168-cd7adns8	1013	15	responses	response	NNS
cord-023168-cd7adns8	1013	16	to	to	IN
cord-023168-cd7adns8	1013	17	viruses	virus	NNS
cord-023168-cd7adns8	1013	18	with	with	IN
cord-023168-cd7adns8	1013	19	oncogenic	oncogenic	JJ
cord-023168-cd7adns8	1013	20	potential	potential	NN
cord-023168-cd7adns8	1013	21	,	,	,
cord-023168-cd7adns8	1013	22	predominantly	predominantly	RB
cord-023168-cd7adns8	1013	23	EBV	EBV	NNP
cord-023168-cd7adns8	1013	24	and	and	CC
cord-023168-cd7adns8	1013	25	human	human	JJ
cord-023168-cd7adns8	1013	26	herpesvirus	herpesvirus	NN
cord-023168-cd7adns8	1013	27	8	8	CD
cord-023168-cd7adns8	1013	28	(	(	-LRB-
cord-023168-cd7adns8	1013	29	HHV8)/Kaposi	HHV8)/Kaposi	NNP
cord-023168-cd7adns8	1013	30	's	's	POS
cord-023168-cd7adns8	1013	31	sarcoma	sarcoma	NN
cord-023168-cd7adns8	1013	32	-	-	HYPH
cord-023168-cd7adns8	1013	33	associated	associate	VBN
cord-023168-cd7adns8	1013	34	herpesvirus	herpesvirus	NN
cord-023168-cd7adns8	1013	35	.	.	.
cord-023168-cd7adns8	1014	1	This	this	DT
cord-023168-cd7adns8	1014	2	allows	allow	VBZ
cord-023168-cd7adns8	1014	3	unregulated	unregulated	JJ
cord-023168-cd7adns8	1014	4	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1014	5	growth	growth	NN
cord-023168-cd7adns8	1014	6	and	and	CC
cord-023168-cd7adns8	1014	7	an	an	DT
cord-023168-cd7adns8	1014	8	accumulation	accumulation	NN
cord-023168-cd7adns8	1014	9	of	of	IN
cord-023168-cd7adns8	1014	10	genetic	genetic	JJ
cord-023168-cd7adns8	1014	11	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1014	12	in	in	IN
cord-023168-cd7adns8	1014	13	B	b	NN
cord-023168-cd7adns8	1014	14	cells	cell	NNS
cord-023168-cd7adns8	1014	15	.	.	.
cord-023168-cd7adns8	1015	1	272	272	CD
cord-023168-cd7adns8	1015	2	Markers	marker	NNS
cord-023168-cd7adns8	1015	3	of	of	IN
cord-023168-cd7adns8	1015	4	B	b	NN
cord-023168-cd7adns8	1015	5	-	-	HYPH
cord-023168-cd7adns8	1015	6	cell	cell	NN
cord-023168-cd7adns8	1015	7	activation	activation	NN
cord-023168-cd7adns8	1015	8	such	such	JJ
cord-023168-cd7adns8	1015	9	as	as	IN
cord-023168-cd7adns8	1015	10	serum	serum	NN
cord-023168-cd7adns8	1015	11	immunoglobulins	immunoglobulin	NNS
cord-023168-cd7adns8	1015	12	and	and	CC
cord-023168-cd7adns8	1015	13	free	free	JJ
cord-023168-cd7adns8	1015	14	light	light	JJ
cord-023168-cd7adns8	1015	15	chains	chain	NNS
cord-023168-cd7adns8	1015	16	,	,	,
cord-023168-cd7adns8	1015	17	and	and	CC
cord-023168-cd7adns8	1015	18	CD4	CD4	NNP
cord-023168-cd7adns8	1015	19	cell	cell	NN
cord-023168-cd7adns8	1015	20	count	count	NN
cord-023168-cd7adns8	1015	21	have	have	VBP
cord-023168-cd7adns8	1015	22	been	be	VBN
cord-023168-cd7adns8	1015	23	suggested	suggest	VBN
cord-023168-cd7adns8	1015	24	as	as	IN
cord-023168-cd7adns8	1015	25	predictive	predictive	JJ
cord-023168-cd7adns8	1015	26	markers	marker	NNS
cord-023168-cd7adns8	1015	27	for	for	IN
cord-023168-cd7adns8	1015	28	the	the	DT
cord-023168-cd7adns8	1015	29	development	development	NN
cord-023168-cd7adns8	1015	30	of	of	IN
cord-023168-cd7adns8	1015	31	NHL	NHL	NNP
cord-023168-cd7adns8	1015	32	in	in	IN
cord-023168-cd7adns8	1015	33	HIV	HIV	NNP
cord-023168-cd7adns8	1015	34	infection	infection	NN
cord-023168-cd7adns8	1015	35	.	.	.
cord-023168-cd7adns8	1016	1	281	281	CD
cord-023168-cd7adns8	1016	2	,	,	,
cord-023168-cd7adns8	1016	3	282	282	CD
cord-023168-cd7adns8	1016	4	Extranodal	Extranodal	NNP
cord-023168-cd7adns8	1016	5	and	and	CC
cord-023168-cd7adns8	1016	6	leptomeningeal	leptomeningeal	JJ
cord-023168-cd7adns8	1016	7	involvement	involvement	NN
cord-023168-cd7adns8	1016	8	,	,	,
cord-023168-cd7adns8	1016	9	and	and	CC
cord-023168-cd7adns8	1016	10	B	b	NN
cord-023168-cd7adns8	1016	11	-	-	HYPH
cord-023168-cd7adns8	1016	12	symptoms	symptom	NNS
cord-023168-cd7adns8	1016	13	occur	occur	VBP
cord-023168-cd7adns8	1016	14	in	in	IN
cord-023168-cd7adns8	1016	15	the	the	DT
cord-023168-cd7adns8	1016	16	majority	majority	NN
cord-023168-cd7adns8	1016	17	of	of	IN
cord-023168-cd7adns8	1016	18	HIV	HIV	NNP
cord-023168-cd7adns8	1016	19	-	-	HYPH
cord-023168-cd7adns8	1016	20	infected	infect	VBN
cord-023168-cd7adns8	1016	21	patients	patient	NNS
cord-023168-cd7adns8	1016	22	with	with	IN
cord-023168-cd7adns8	1016	23	NHL	NHL	NNP
cord-023168-cd7adns8	1016	24	and	and	CC
cord-023168-cd7adns8	1016	25	the	the	DT
cord-023168-cd7adns8	1016	26	bone	bone	NN
cord-023168-cd7adns8	1016	27	marrow	marrow	NN
cord-023168-cd7adns8	1016	28	is	be	VBZ
cord-023168-cd7adns8	1016	29	commonly	commonly	RB
cord-023168-cd7adns8	1016	30	involved	involve	VBN
cord-023168-cd7adns8	1016	31	.	.	.
cord-023168-cd7adns8	1017	1	The	the	DT
cord-023168-cd7adns8	1017	2	most	most	RBS
cord-023168-cd7adns8	1017	3	common	common	JJ
cord-023168-cd7adns8	1017	4	extranodal	extranodal	NNP
cord-023168-cd7adns8	1017	5	site	site	NN
cord-023168-cd7adns8	1017	6	to	to	TO
cord-023168-cd7adns8	1017	7	be	be	VB
cord-023168-cd7adns8	1017	8	involved	involve	VBN
cord-023168-cd7adns8	1017	9	is	be	VBZ
cord-023168-cd7adns8	1017	10	the	the	DT
cord-023168-cd7adns8	1017	11	incidence	incidence	NN
cord-023168-cd7adns8	1017	12	of	of	IN
cord-023168-cd7adns8	1017	13	moderate	moderate	JJ
cord-023168-cd7adns8	1017	14	thrombocytopenia	thrombocytopenia	NNS
cord-023168-cd7adns8	1017	15	(	(	-LRB-
cord-023168-cd7adns8	1017	16	<	<	XX
cord-023168-cd7adns8	1017	17	50	50	CD
cord-023168-cd7adns8	1017	18	×	×	NN
cord-023168-cd7adns8	1017	19	10	10	CD
cord-023168-cd7adns8	1017	20	9	9	CD
cord-023168-cd7adns8	1017	21	/L	/L	.
cord-023168-cd7adns8	1017	22	)	)	-RRB-
cord-023168-cd7adns8	1017	23	is	be	VBZ
cord-023168-cd7adns8	1017	24	3.7	3.7	CD
cord-023168-cd7adns8	1017	25	%	%	NN
cord-023168-cd7adns8	1017	26	,	,	,
cord-023168-cd7adns8	1017	27	though	though	IN
cord-023168-cd7adns8	1017	28	this	this	DT
cord-023168-cd7adns8	1017	29	is	be	VBZ
cord-023168-cd7adns8	1017	30	higher	high	JJR
cord-023168-cd7adns8	1017	31	in	in	IN
cord-023168-cd7adns8	1017	32	those	those	DT
cord-023168-cd7adns8	1017	33	with	with	IN
cord-023168-cd7adns8	1017	34	clinical	clinical	JJ
cord-023168-cd7adns8	1017	35	AIDS	AIDS	NNP
cord-023168-cd7adns8	1017	36	(	(	-LRB-
cord-023168-cd7adns8	1017	37	8.7	8.7	CD
cord-023168-cd7adns8	1017	38	%	%	NN
cord-023168-cd7adns8	1017	39	)	)	-RRB-
cord-023168-cd7adns8	1017	40	.	.	.
cord-023168-cd7adns8	1018	1	257	257	CD
cord-023168-cd7adns8	1018	2	,	,	,
cord-023168-cd7adns8	1018	3	258	258	CD
cord-023168-cd7adns8	1018	4	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	1018	5	is	be	VBZ
cord-023168-cd7adns8	1018	6	more	more	RBR
cord-023168-cd7adns8	1018	7	common	common	JJ
cord-023168-cd7adns8	1018	8	in	in	IN
cord-023168-cd7adns8	1018	9	those	those	DT
cord-023168-cd7adns8	1018	10	who	who	WP
cord-023168-cd7adns8	1018	11	abuse	abuse	VBP
cord-023168-cd7adns8	1018	12	drugs	drug	NNS
cord-023168-cd7adns8	1018	13	,	,	,
cord-023168-cd7adns8	1018	14	have	have	VBP
cord-023168-cd7adns8	1018	15	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	1018	16	infections	infection	NNS
cord-023168-cd7adns8	1018	17	and	and	CC
cord-023168-cd7adns8	1018	18	malignant	malignant	JJ
cord-023168-cd7adns8	1018	19	disorders	disorder	NNS
cord-023168-cd7adns8	1018	20	of	of	IN
cord-023168-cd7adns8	1018	21	the	the	DT
cord-023168-cd7adns8	1018	22	bone	bone	NN
cord-023168-cd7adns8	1018	23	marrow	marrow	NN
cord-023168-cd7adns8	1018	24	(	(	-LRB-
cord-023168-cd7adns8	1018	25	e.g.	e.g.	JJ
cord-023168-cd7adns8	1018	26	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1018	27	)	)	-RRB-
cord-023168-cd7adns8	1018	28	,	,	,
cord-023168-cd7adns8	1018	29	and	and	CC
cord-023168-cd7adns8	1018	30	it	-PRON-	PRP
cord-023168-cd7adns8	1018	31	may	may	MD
cord-023168-cd7adns8	1018	32	also	also	RB
cord-023168-cd7adns8	1018	33	be	be	VB
cord-023168-cd7adns8	1018	34	a	a	DT
cord-023168-cd7adns8	1018	35	side	side	NN
cord-023168-cd7adns8	1018	36	-	-	HYPH
cord-023168-cd7adns8	1018	37	effect	effect	NN
cord-023168-cd7adns8	1018	38	of	of	IN
cord-023168-cd7adns8	1018	39	therapeutic	therapeutic	JJ
cord-023168-cd7adns8	1018	40	drugs	drug	NNS
cord-023168-cd7adns8	1018	41	.	.	.
cord-023168-cd7adns8	1019	1	259	259	CD
cord-023168-cd7adns8	1020	1	The	the	DT
cord-023168-cd7adns8	1020	2	most	most	RBS
cord-023168-cd7adns8	1020	3	common	common	JJ
cord-023168-cd7adns8	1020	4	cause	cause	NN
cord-023168-cd7adns8	1020	5	of	of	IN
cord-023168-cd7adns8	1020	6	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1020	7	in	in	IN
cord-023168-cd7adns8	1020	8	HIV	HIV	NNP
cord-023168-cd7adns8	1020	9	infection	infection	NN
cord-023168-cd7adns8	1020	10	is	be	VBZ
cord-023168-cd7adns8	1020	11	immune	immune	JJ
cord-023168-cd7adns8	1020	12	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1020	13	which	which	WDT
cord-023168-cd7adns8	1020	14	may	may	MD
cord-023168-cd7adns8	1020	15	be	be	VB
cord-023168-cd7adns8	1020	16	associated	associate	VBN
cord-023168-cd7adns8	1020	17	with	with	IN
cord-023168-cd7adns8	1020	18	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1020	19	C	C	NNP
cord-023168-cd7adns8	1020	20	co	co	NN
cord-023168-cd7adns8	1020	21	-	-	NN
cord-023168-cd7adns8	1020	22	infection	infection	NN
cord-023168-cd7adns8	1020	23	,	,	,
cord-023168-cd7adns8	1020	24	and	and	CC
cord-023168-cd7adns8	1020	25	produces	produce	VBZ
cord-023168-cd7adns8	1020	26	decreased	decreased	JJ
cord-023168-cd7adns8	1020	27	platelet	platelet	NN
cord-023168-cd7adns8	1020	28	survival	survival	NN
cord-023168-cd7adns8	1020	29	,	,	,
cord-023168-cd7adns8	1020	30	particularly	particularly	RB
cord-023168-cd7adns8	1020	31	at	at	IN
cord-023168-cd7adns8	1020	32	CD4	CD4	NNP
cord-023168-cd7adns8	1020	33	counts	count	VBZ
cord-023168-cd7adns8	1020	34	below	below	IN
cord-023168-cd7adns8	1020	35	200/µL.	200/µl.	CD
cord-023168-cd7adns8	1021	1	The	the	DT
cord-023168-cd7adns8	1021	2	anti	anti	JJ
cord-023168-cd7adns8	1021	3	-	-	JJ
cord-023168-cd7adns8	1021	4	platelet	platelet	JJ
cord-023168-cd7adns8	1021	5	antibodies	antibody	NNS
cord-023168-cd7adns8	1021	6	,	,	,
cord-023168-cd7adns8	1021	7	immune	immune	JJ
cord-023168-cd7adns8	1021	8	complexes	complex	NNS
cord-023168-cd7adns8	1021	9	and	and	CC
cord-023168-cd7adns8	1021	10	cross	cross	NN
cord-023168-cd7adns8	1021	11	-	-	JJ
cord-023168-cd7adns8	1021	12	reacting	react	VBG
cord-023168-cd7adns8	1021	13	antibodies	antibody	NNS
cord-023168-cd7adns8	1021	14	to	to	IN
cord-023168-cd7adns8	1021	15	HIV	HIV	NNP
cord-023168-cd7adns8	1021	16	envelope	envelope	NN
cord-023168-cd7adns8	1021	17	proteins	protein	NNS
cord-023168-cd7adns8	1021	18	and	and	CC
cord-023168-cd7adns8	1021	19	platelets	platelet	NNS
cord-023168-cd7adns8	1021	20	,	,	,
cord-023168-cd7adns8	1021	21	which	which	WDT
cord-023168-cd7adns8	1021	22	occur	occur	VBP
cord-023168-cd7adns8	1021	23	in	in	IN
cord-023168-cd7adns8	1021	24	HIV	HIV	NNP
cord-023168-cd7adns8	1021	25	-	-	HYPH
cord-023168-cd7adns8	1021	26	associated	associate	VBN
cord-023168-cd7adns8	1021	27	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1021	28	259	259	CD
cord-023168-cd7adns8	1021	29	,	,	,
cord-023168-cd7adns8	1021	30	260	260	CD
cord-023168-cd7adns8	1021	31	may	may	MD
cord-023168-cd7adns8	1021	32	also	also	RB
cord-023168-cd7adns8	1021	33	contribute	contribute	VB
cord-023168-cd7adns8	1021	34	to	to	IN
cord-023168-cd7adns8	1021	35	generation	generation	NN
cord-023168-cd7adns8	1021	36	of	of	IN
cord-023168-cd7adns8	1021	37	reactive	reactive	JJ
cord-023168-cd7adns8	1021	38	oxygen	oxygen	NN
cord-023168-cd7adns8	1021	39	species	specie	NNS
cord-023168-cd7adns8	1021	40	.	.	.
cord-023168-cd7adns8	1022	1	261	261	CD
cord-023168-cd7adns8	1022	2	Platelet	platelet	NN
cord-023168-cd7adns8	1022	3	production	production	NN
cord-023168-cd7adns8	1022	4	can	can	MD
cord-023168-cd7adns8	1022	5	also	also	RB
cord-023168-cd7adns8	1022	6	be	be	VB
cord-023168-cd7adns8	1022	7	affected	affect	VBN
cord-023168-cd7adns8	1022	8	in	in	IN
cord-023168-cd7adns8	1022	9	HIV	HIV	NNP
cord-023168-cd7adns8	1022	10	infection	infection	NN
cord-023168-cd7adns8	1022	11	and	and	CC
cord-023168-cd7adns8	1022	12	may	may	MD
cord-023168-cd7adns8	1022	13	explain	explain	VB
cord-023168-cd7adns8	1022	14	the	the	DT
cord-023168-cd7adns8	1022	15	high	high	JJ
cord-023168-cd7adns8	1022	16	levels	level	NNS
cord-023168-cd7adns8	1022	17	of	of	IN
cord-023168-cd7adns8	1022	18	thrombopoietin	thrombopoietin	NNP
cord-023168-cd7adns8	1022	19	that	that	WDT
cord-023168-cd7adns8	1022	20	have	have	VBP
cord-023168-cd7adns8	1022	21	been	be	VBN
cord-023168-cd7adns8	1022	22	documented	document	VBN
cord-023168-cd7adns8	1022	23	in	in	IN
cord-023168-cd7adns8	1022	24	HIVrelated	HIVrelated	NNP
cord-023168-cd7adns8	1022	25	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1022	26	.	.	.
cord-023168-cd7adns8	1023	1	262	262	CD
cord-023168-cd7adns8	1024	1	Some	some	DT
cord-023168-cd7adns8	1024	2	cases	case	NNS
cord-023168-cd7adns8	1024	3	of	of	IN
cord-023168-cd7adns8	1024	4	HIV	HIV	NNP
cord-023168-cd7adns8	1024	5	-	-	HYPH
cord-023168-cd7adns8	1024	6	related	relate	VBN
cord-023168-cd7adns8	1024	7	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1024	8	may	may	MD
cord-023168-cd7adns8	1024	9	undergo	undergo	VB
cord-023168-cd7adns8	1024	10	spontaneous	spontaneous	JJ
cord-023168-cd7adns8	1024	11	remission	remission	NN
cord-023168-cd7adns8	1024	12	so	so	IN
cord-023168-cd7adns8	1024	13	treatment	treatment	NN
cord-023168-cd7adns8	1024	14	of	of	IN
cord-023168-cd7adns8	1024	15	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1024	16	is	be	VBZ
cord-023168-cd7adns8	1024	17	usually	usually	RB
cord-023168-cd7adns8	1024	18	only	only	RB
cord-023168-cd7adns8	1024	19	initiated	initiate	VBN
cord-023168-cd7adns8	1024	20	if	if	IN
cord-023168-cd7adns8	1024	21	it	-PRON-	PRP
cord-023168-cd7adns8	1024	22	is	be	VBZ
cord-023168-cd7adns8	1024	23	associated	associate	VBN
cord-023168-cd7adns8	1024	24	with	with	IN
cord-023168-cd7adns8	1024	25	bleeding	bleeding	NN
cord-023168-cd7adns8	1024	26	,	,	,
cord-023168-cd7adns8	1024	27	which	which	WDT
cord-023168-cd7adns8	1024	28	is	be	VBZ
cord-023168-cd7adns8	1024	29	unusual	unusual	JJ
cord-023168-cd7adns8	1024	30	.	.	.
cord-023168-cd7adns8	1025	1	259	259	CD
cord-023168-cd7adns8	1026	1	The	the	DT
cord-023168-cd7adns8	1026	2	first	first	JJ
cord-023168-cd7adns8	1026	3	line	line	NN
cord-023168-cd7adns8	1026	4	of	of	IN
cord-023168-cd7adns8	1026	5	treatment	treatment	NN
cord-023168-cd7adns8	1026	6	involves	involve	VBZ
cord-023168-cd7adns8	1026	7	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1026	8	therapy	therapy	NN
cord-023168-cd7adns8	1026	9	with	with	IN
cord-023168-cd7adns8	1026	10	the	the	DT
cord-023168-cd7adns8	1026	11	aim	aim	NN
cord-023168-cd7adns8	1026	12	of	of	IN
cord-023168-cd7adns8	1026	13	achieving	achieve	VBG
cord-023168-cd7adns8	1026	14	undetectable	undetectable	JJ
cord-023168-cd7adns8	1026	15	plasma	plasma	NN
cord-023168-cd7adns8	1026	16	HIV	HIV	NNP
cord-023168-cd7adns8	1026	17	viraemia	viraemia	NN
cord-023168-cd7adns8	1026	18	.	.	.
cord-023168-cd7adns8	1027	1	263	263	CD
cord-023168-cd7adns8	1028	1	,	,	,
cord-023168-cd7adns8	1028	2	264	264	CD
cord-023168-cd7adns8	1029	1	Any	any	DT
cord-023168-cd7adns8	1029	2	drugs	drug	NNS
cord-023168-cd7adns8	1029	3	that	that	WDT
cord-023168-cd7adns8	1029	4	may	may	MD
cord-023168-cd7adns8	1029	5	be	be	VB
cord-023168-cd7adns8	1029	6	associated	associate	VBN
cord-023168-cd7adns8	1029	7	with	with	IN
cord-023168-cd7adns8	1029	8	causing	cause	VBG
cord-023168-cd7adns8	1029	9	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1029	10	should	should	MD
cord-023168-cd7adns8	1029	11	be	be	VB
cord-023168-cd7adns8	1029	12	withdrawn	withdraw	VBN
cord-023168-cd7adns8	1029	13	and	and	CC
cord-023168-cd7adns8	1029	14	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	1029	15	infections	infection	NNS
cord-023168-cd7adns8	1029	16	or	or	CC
cord-023168-cd7adns8	1029	17	secondary	secondary	JJ
cord-023168-cd7adns8	1029	18	malignancies	malignancy	NNS
cord-023168-cd7adns8	1029	19	treated	treat	VBN
cord-023168-cd7adns8	1029	20	.	.	.
cord-023168-cd7adns8	1030	1	The	the	DT
cord-023168-cd7adns8	1030	2	treatment	treatment	NN
cord-023168-cd7adns8	1030	3	of	of	IN
cord-023168-cd7adns8	1030	4	immune	immune	JJ
cord-023168-cd7adns8	1030	5	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1030	6	is	be	VBZ
cord-023168-cd7adns8	1030	7	the	the	DT
cord-023168-cd7adns8	1030	8	same	same	JJ
cord-023168-cd7adns8	1030	9	as	as	IN
cord-023168-cd7adns8	1030	10	in	in	IN
cord-023168-cd7adns8	1030	11	non	non	JJ
cord-023168-cd7adns8	1030	12	-	-	JJ
cord-023168-cd7adns8	1030	13	HIV	hiv	JJ
cord-023168-cd7adns8	1030	14	cases	case	NNS
cord-023168-cd7adns8	1030	15	and	and	CC
cord-023168-cd7adns8	1030	16	options	option	NNS
cord-023168-cd7adns8	1030	17	include	include	VBP
cord-023168-cd7adns8	1030	18	a	a	DT
cord-023168-cd7adns8	1030	19	short	short	JJ
cord-023168-cd7adns8	1030	20	course	course	NN
cord-023168-cd7adns8	1030	21	of	of	IN
cord-023168-cd7adns8	1030	22	steroids	steroid	NNS
cord-023168-cd7adns8	1030	23	,	,	,
cord-023168-cd7adns8	1030	24	intravenous	intravenous	JJ
cord-023168-cd7adns8	1030	25	immunoglobulin	immunoglobulin	NN
cord-023168-cd7adns8	1030	26	(	(	-LRB-
cord-023168-cd7adns8	1030	27	short	short	RB
cord-023168-cd7adns8	1030	28	-	-	HYPH
cord-023168-cd7adns8	1030	29	lived	live	VBN
cord-023168-cd7adns8	1030	30	response	response	NN
cord-023168-cd7adns8	1030	31	)	)	-RRB-
cord-023168-cd7adns8	1030	32	,	,	,
cord-023168-cd7adns8	1030	33	anti	anti	JJ
cord-023168-cd7adns8	1030	34	-	-	JJ
cord-023168-cd7adns8	1030	35	D	d	JJ
cord-023168-cd7adns8	1030	36	,	,	,
cord-023168-cd7adns8	1030	37	interferon	interferon	NN
cord-023168-cd7adns8	1030	38	-	-	HYPH
cord-023168-cd7adns8	1030	39	α	α	NN
cord-023168-cd7adns8	1030	40	or	or	CC
cord-023168-cd7adns8	1030	41	splenectomy	splenectomy	NN
cord-023168-cd7adns8	1030	42	.	.	.
cord-023168-cd7adns8	1031	1	Although	although	IN
cord-023168-cd7adns8	1031	2	there	there	EX
cord-023168-cd7adns8	1031	3	are	be	VBP
cord-023168-cd7adns8	1031	4	multiple	multiple	JJ
cord-023168-cd7adns8	1031	5	causes	cause	NNS
cord-023168-cd7adns8	1031	6	of	of	IN
cord-023168-cd7adns8	1031	7	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1031	8	in	in	IN
cord-023168-cd7adns8	1031	9	HIV	HIV	NNP
cord-023168-cd7adns8	1031	10	-	-	HYPH
cord-023168-cd7adns8	1031	11	positive	positive	JJ
cord-023168-cd7adns8	1031	12	individuals	individual	NNS
cord-023168-cd7adns8	1031	13	,	,	,
cord-023168-cd7adns8	1031	14	one	one	CD
cord-023168-cd7adns8	1031	15	of	of	IN
cord-023168-cd7adns8	1031	16	the	the	DT
cord-023168-cd7adns8	1031	17	most	most	RBS
cord-023168-cd7adns8	1031	18	devastating	devastating	JJ
cord-023168-cd7adns8	1031	19	is	be	VBZ
cord-023168-cd7adns8	1031	20	the	the	DT
cord-023168-cd7adns8	1031	21	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1031	22	microangiopathy	microangiopathy	NN
cord-023168-cd7adns8	1031	23	of	of	IN
cord-023168-cd7adns8	1031	24	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1031	25	thrombocytopenic	thrombocytopenic	JJ
cord-023168-cd7adns8	1031	26	purpura	purpura	NN
cord-023168-cd7adns8	1031	27	(	(	-LRB-
cord-023168-cd7adns8	1031	28	TTP	TTP	NNP
cord-023168-cd7adns8	1031	29	)	)	-RRB-
cord-023168-cd7adns8	1031	30	.	.	.
cord-023168-cd7adns8	1032	1	This	this	DT
cord-023168-cd7adns8	1032	2	is	be	VBZ
cord-023168-cd7adns8	1032	3	because	because	IN
cord-023168-cd7adns8	1032	4	the	the	DT
cord-023168-cd7adns8	1032	5	combination	combination	NN
cord-023168-cd7adns8	1032	6	of	of	IN
cord-023168-cd7adns8	1032	7	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1032	8	anaemia	anaemia	NN
cord-023168-cd7adns8	1032	9	and	and	CC
cord-023168-cd7adns8	1032	10	microthrombi	microthrombi	NNP
cord-023168-cd7adns8	1032	11	has	have	VBZ
cord-023168-cd7adns8	1032	12	a	a	DT
cord-023168-cd7adns8	1032	13	very	very	RB
cord-023168-cd7adns8	1032	14	poor	poor	JJ
cord-023168-cd7adns8	1032	15	prognosis	prognosis	NN
cord-023168-cd7adns8	1032	16	.	.	.
cord-023168-cd7adns8	1033	1	Symptoms	symptom	NNS
cord-023168-cd7adns8	1033	2	are	be	VBP
cord-023168-cd7adns8	1033	3	nonspecific	nonspecific	JJ
cord-023168-cd7adns8	1033	4	and	and	CC
cord-023168-cd7adns8	1033	5	may	may	MD
cord-023168-cd7adns8	1033	6	include	include	VB
cord-023168-cd7adns8	1033	7	fever	fever	NN
cord-023168-cd7adns8	1033	8	,	,	,
cord-023168-cd7adns8	1033	9	headache	headache	NN
cord-023168-cd7adns8	1033	10	,	,	,
cord-023168-cd7adns8	1033	11	bleeding	bleeding	NN
cord-023168-cd7adns8	1033	12	and	and	CC
cord-023168-cd7adns8	1033	13	changes	change	NNS
cord-023168-cd7adns8	1033	14	in	in	IN
cord-023168-cd7adns8	1033	15	consciousness	consciousness	NN
cord-023168-cd7adns8	1033	16	.	.	.
cord-023168-cd7adns8	1034	1	If	if	IN
cord-023168-cd7adns8	1034	2	TTP	TTP	NNP
cord-023168-cd7adns8	1034	3	is	be	VBZ
cord-023168-cd7adns8	1034	4	suspected	suspect	VBN
cord-023168-cd7adns8	1034	5	,	,	,
cord-023168-cd7adns8	1034	6	an	an	DT
cord-023168-cd7adns8	1034	7	urgent	urgent	JJ
cord-023168-cd7adns8	1034	8	blood	blood	NN
cord-023168-cd7adns8	1034	9	film	film	NN
cord-023168-cd7adns8	1034	10	should	should	MD
cord-023168-cd7adns8	1034	11	be	be	VB
cord-023168-cd7adns8	1034	12	requested	request	VBN
cord-023168-cd7adns8	1034	13	and	and	CC
cord-023168-cd7adns8	1034	14	the	the	DT
cord-023168-cd7adns8	1034	15	combination	combination	NN
cord-023168-cd7adns8	1034	16	of	of	IN
cord-023168-cd7adns8	1034	17	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1034	18	with	with	IN
cord-023168-cd7adns8	1034	19	red	red	JJ
cord-023168-cd7adns8	1034	20	cell	cell	NN
cord-023168-cd7adns8	1034	21	fragmentation	fragmentation	NN
cord-023168-cd7adns8	1034	22	is	be	VBZ
cord-023168-cd7adns8	1034	23	highly	highly	RB
cord-023168-cd7adns8	1034	24	suggestive	suggestive	JJ
cord-023168-cd7adns8	1034	25	of	of	IN
cord-023168-cd7adns8	1034	26	TTP	TTP	NNP
cord-023168-cd7adns8	1034	27	.	.	.
cord-023168-cd7adns8	1035	1	TTP	TTP	NNP
cord-023168-cd7adns8	1035	2	associated	associate	VBN
cord-023168-cd7adns8	1035	3	with	with	IN
cord-023168-cd7adns8	1035	4	HIV	HIV	NNP
cord-023168-cd7adns8	1035	5	infection	infection	NN
cord-023168-cd7adns8	1035	6	was	be	VBD
cord-023168-cd7adns8	1035	7	more	more	RBR
cord-023168-cd7adns8	1035	8	frequent	frequent	JJ
cord-023168-cd7adns8	1035	9	before	before	IN
cord-023168-cd7adns8	1035	10	the	the	DT
cord-023168-cd7adns8	1035	11	introduction	introduction	NN
cord-023168-cd7adns8	1035	12	of	of	IN
cord-023168-cd7adns8	1035	13	ART	art	NN
cord-023168-cd7adns8	1035	14	and	and	CC
cord-023168-cd7adns8	1035	15	is	be	VBZ
cord-023168-cd7adns8	1035	16	more	more	RBR
cord-023168-cd7adns8	1035	17	common	common	JJ
cord-023168-cd7adns8	1035	18	if	if	IN
cord-023168-cd7adns8	1035	19	adherence	adherence	NN
cord-023168-cd7adns8	1035	20	to	to	IN
cord-023168-cd7adns8	1035	21	treatment	treatment	NN
cord-023168-cd7adns8	1035	22	is	be	VBZ
cord-023168-cd7adns8	1035	23	poor	poor	JJ
cord-023168-cd7adns8	1035	24	or	or	CC
cord-023168-cd7adns8	1035	25	resistance	resistance	NN
cord-023168-cd7adns8	1035	26	to	to	IN
cord-023168-cd7adns8	1035	27	therapy	therapy	NN
cord-023168-cd7adns8	1035	28	has	have	VBZ
cord-023168-cd7adns8	1035	29	developed	develop	VBN
cord-023168-cd7adns8	1035	30	.	.	.
cord-023168-cd7adns8	1036	1	265	265	CD
cord-023168-cd7adns8	1036	2	TTP	TTP	NNP
cord-023168-cd7adns8	1036	3	is	be	VBZ
cord-023168-cd7adns8	1036	4	thought	think	VBN
cord-023168-cd7adns8	1036	5	to	to	TO
cord-023168-cd7adns8	1036	6	be	be	VB
cord-023168-cd7adns8	1036	7	due	due	JJ
cord-023168-cd7adns8	1036	8	to	to	IN
cord-023168-cd7adns8	1036	9	endothelial	endothelial	JJ
cord-023168-cd7adns8	1036	10	damage	damage	NN
cord-023168-cd7adns8	1036	11	,	,	,
cord-023168-cd7adns8	1036	12	but	but	CC
cord-023168-cd7adns8	1036	13	unlike	unlike	IN
cord-023168-cd7adns8	1036	14	the	the	DT
cord-023168-cd7adns8	1036	15	situation	situation	NN
cord-023168-cd7adns8	1036	16	in	in	IN
cord-023168-cd7adns8	1036	17	non	non	JJ
cord-023168-cd7adns8	1036	18	-	-	JJ
cord-023168-cd7adns8	1036	19	HIV	hiv	JJ
cord-023168-cd7adns8	1036	20	-	-	HYPH
cord-023168-cd7adns8	1036	21	infected	infect	VBN
cord-023168-cd7adns8	1036	22	individuals	individual	NNS
cord-023168-cd7adns8	1036	23	,	,	,
cord-023168-cd7adns8	1036	24	low	low	JJ
cord-023168-cd7adns8	1036	25	levels	level	NNS
cord-023168-cd7adns8	1036	26	of	of	IN
cord-023168-cd7adns8	1036	27	ADAMTS-13	ADAMTS-13	NNPS
cord-023168-cd7adns8	1036	28	are	be	VBP
cord-023168-cd7adns8	1036	29	not	not	RB
cord-023168-cd7adns8	1036	30	a	a	DT
cord-023168-cd7adns8	1036	31	useful	useful	JJ
cord-023168-cd7adns8	1036	32	predictor	predictor	NN
cord-023168-cd7adns8	1036	33	of	of	IN
cord-023168-cd7adns8	1036	34	outcome	outcome	NN
cord-023168-cd7adns8	1036	35	.	.	.
cord-023168-cd7adns8	1037	1	266	266	CD
cord-023168-cd7adns8	1037	2	Treatment	treatment	NN
cord-023168-cd7adns8	1037	3	of	of	IN
cord-023168-cd7adns8	1037	4	TTP	TTP	NNP
cord-023168-cd7adns8	1037	5	involves	involve	VBZ
cord-023168-cd7adns8	1037	6	plasma	plasma	NN
cord-023168-cd7adns8	1037	7	exchange	exchange	NN
cord-023168-cd7adns8	1037	8	,	,	,
cord-023168-cd7adns8	1037	9	and	and	CC
cord-023168-cd7adns8	1037	10	although	although	IN
cord-023168-cd7adns8	1037	11	refractoriness	refractoriness	NNP
cord-023168-cd7adns8	1037	12	may	may	MD
cord-023168-cd7adns8	1037	13	occur	occur	VB
cord-023168-cd7adns8	1037	14	,	,	,
cord-023168-cd7adns8	1037	15	this	this	DT
cord-023168-cd7adns8	1037	16	can	can	MD
cord-023168-cd7adns8	1037	17	be	be	VB
cord-023168-cd7adns8	1037	18	corrected	correct	VBN
cord-023168-cd7adns8	1037	19	by	by	IN
cord-023168-cd7adns8	1037	20	ART	art	NN
cord-023168-cd7adns8	1037	21	in	in	IN
cord-023168-cd7adns8	1037	22	some	some	DT
cord-023168-cd7adns8	1037	23	cases	case	NNS
cord-023168-cd7adns8	1037	24	.	.	.
cord-023168-cd7adns8	1038	1	266	266	CD
cord-023168-cd7adns8	1039	1	If	if	IN
cord-023168-cd7adns8	1039	2	ART	art	NN
cord-023168-cd7adns8	1039	3	is	be	VBZ
cord-023168-cd7adns8	1039	4	administered	administer	VBN
cord-023168-cd7adns8	1039	5	in	in	IN
cord-023168-cd7adns8	1039	6	these	these	DT
cord-023168-cd7adns8	1039	7	cases	case	NNS
cord-023168-cd7adns8	1039	8	it	-PRON-	PRP
cord-023168-cd7adns8	1039	9	is	be	VBZ
cord-023168-cd7adns8	1039	10	important	important	JJ
cord-023168-cd7adns8	1039	11	to	to	TO
cord-023168-cd7adns8	1039	12	maintain	maintain	VB
cord-023168-cd7adns8	1039	13	adherence	adherence	NN
cord-023168-cd7adns8	1039	14	throughout	throughout	IN
cord-023168-cd7adns8	1039	15	the	the	DT
cord-023168-cd7adns8	1039	16	period	period	NN
cord-023168-cd7adns8	1039	17	of	of	IN
cord-023168-cd7adns8	1039	18	plasma	plasma	NN
cord-023168-cd7adns8	1039	19	exchange	exchange	NN
cord-023168-cd7adns8	1039	20	.	.	.
cord-023168-cd7adns8	1040	1	If	if	IN
cord-023168-cd7adns8	1040	2	apheresis	apheresis	NN
cord-023168-cd7adns8	1040	3	facilities	facility	NNS
cord-023168-cd7adns8	1040	4	are	be	VBP
cord-023168-cd7adns8	1040	5	limited	limited	JJ
cord-023168-cd7adns8	1040	6	,	,	,
cord-023168-cd7adns8	1040	7	plasma	plasma	NN
cord-023168-cd7adns8	1040	8	infusions	infusion	NNS
cord-023168-cd7adns8	1040	9	alone	alone	RB
cord-023168-cd7adns8	1040	10	(	(	-LRB-
cord-023168-cd7adns8	1040	11	30	30	CD
cord-023168-cd7adns8	1040	12	mL/	mL/	NNP
cord-023168-cd7adns8	1040	13	kg	kg	NN
cord-023168-cd7adns8	1040	14	per	per	IN
cord-023168-cd7adns8	1040	15	day	day	NN
cord-023168-cd7adns8	1040	16	)	)	-RRB-
cord-023168-cd7adns8	1040	17	may	may	MD
cord-023168-cd7adns8	1040	18	also	also	RB
cord-023168-cd7adns8	1040	19	produce	produce	VB
cord-023168-cd7adns8	1040	20	a	a	DT
cord-023168-cd7adns8	1040	21	response	response	NN
cord-023168-cd7adns8	1040	22	.	.	.
cord-023168-cd7adns8	1041	1	267	267	CD
cord-023168-cd7adns8	1041	2	ART	art	NN
cord-023168-cd7adns8	1041	3	should	should	MD
cord-023168-cd7adns8	1041	4	also	also	RB
cord-023168-cd7adns8	1041	5	be	be	VB
cord-023168-cd7adns8	1041	6	administered	administer	VBN
cord-023168-cd7adns8	1041	7	immediately	immediately	RB
cord-023168-cd7adns8	1041	8	after	after	IN
cord-023168-cd7adns8	1041	9	plasma	plasma	NN
cord-023168-cd7adns8	1041	10	exchange	exchange	NN
cord-023168-cd7adns8	1041	11	to	to	TO
cord-023168-cd7adns8	1041	12	minimize	minimize	VB
cord-023168-cd7adns8	1041	13	drug	drug	NN
cord-023168-cd7adns8	1041	14	removal	removal	NN
cord-023168-cd7adns8	1041	15	.	.	.
cord-023168-cd7adns8	1042	1	Patients	patient	NNS
cord-023168-cd7adns8	1042	2	with	with	IN
cord-023168-cd7adns8	1042	3	a	a	DT
cord-023168-cd7adns8	1042	4	viral	viral	JJ
cord-023168-cd7adns8	1042	5	load	load	NN
cord-023168-cd7adns8	1042	6	of	of	IN
cord-023168-cd7adns8	1042	7	less	less	JJR
cord-023168-cd7adns8	1042	8	than	than	IN
cord-023168-cd7adns8	1042	9	500	500	CD
cord-023168-cd7adns8	1042	10	000	000	CD
cord-023168-cd7adns8	1042	11	copies	copy	NNS
cord-023168-cd7adns8	1042	12	/	/	SYM
cord-023168-cd7adns8	1042	13	mL	ml	NN
cord-023168-cd7adns8	1042	14	generally	generally	RB
cord-023168-cd7adns8	1042	15	require	require	VBP
cord-023168-cd7adns8	1042	16	fewer	few	JJR
cord-023168-cd7adns8	1042	17	plasma	plasma	NN
cord-023168-cd7adns8	1042	18	exchanges	exchange	NNS
cord-023168-cd7adns8	1042	19	for	for	IN
cord-023168-cd7adns8	1042	20	remission	remission	NN
cord-023168-cd7adns8	1042	21	than	than	IN
cord-023168-cd7adns8	1042	22	those	those	DT
cord-023168-cd7adns8	1042	23	with	with	IN
cord-023168-cd7adns8	1042	24	a	a	DT
cord-023168-cd7adns8	1042	25	higher	high	JJR
cord-023168-cd7adns8	1042	26	load	load	NN
cord-023168-cd7adns8	1042	27	.	.	.
cord-023168-cd7adns8	1043	1	265	265	CD
cord-023168-cd7adns8	1043	2	Survival	survival	NN
cord-023168-cd7adns8	1043	3	of	of	IN
cord-023168-cd7adns8	1043	4	patients	patient	NNS
cord-023168-cd7adns8	1043	5	with	with	IN
cord-023168-cd7adns8	1043	6	HIV	HIV	NNP
cord-023168-cd7adns8	1043	7	-	-	HYPH
cord-023168-cd7adns8	1043	8	associated	associate	VBN
cord-023168-cd7adns8	1043	9	TTP	TTP	NNP
cord-023168-cd7adns8	1043	10	in	in	IN
cord-023168-cd7adns8	1043	11	the	the	DT
cord-023168-cd7adns8	1043	12	pre	pre	JJ
cord-023168-cd7adns8	1043	13	-	-	JJ
cord-023168-cd7adns8	1043	14	ART	art	NN
cord-023168-cd7adns8	1043	15	era	era	NN
cord-023168-cd7adns8	1043	16	was	be	VBD
cord-023168-cd7adns8	1043	17	rarely	rarely	RB
cord-023168-cd7adns8	1043	18	longer	long	JJR
cord-023168-cd7adns8	1043	19	than	than	IN
cord-023168-cd7adns8	1043	20	2	2	CD
cord-023168-cd7adns8	1043	21	years	year	NNS
cord-023168-cd7adns8	1043	22	,	,	,
cord-023168-cd7adns8	1043	23	even	even	RB
cord-023168-cd7adns8	1043	24	with	with	IN
cord-023168-cd7adns8	1043	25	plasma	plasma	NN
cord-023168-cd7adns8	1043	26	exchange	exchange	NN
cord-023168-cd7adns8	1043	27	and	and	CC
cord-023168-cd7adns8	1043	28	steroid	steroid	NN
cord-023168-cd7adns8	1043	29	treatment	treatment	NN
cord-023168-cd7adns8	1043	30	,	,	,
cord-023168-cd7adns8	1043	31	but	but	CC
cord-023168-cd7adns8	1043	32	for	for	IN
cord-023168-cd7adns8	1043	33	patients	patient	NNS
cord-023168-cd7adns8	1043	34	who	who	WP
cord-023168-cd7adns8	1043	35	are	be	VBP
cord-023168-cd7adns8	1043	36	compliant	compliant	JJ
cord-023168-cd7adns8	1043	37	with	with	IN
cord-023168-cd7adns8	1043	38	ART	art	NN
cord-023168-cd7adns8	1043	39	the	the	DT
cord-023168-cd7adns8	1043	40	mortality	mortality	NN
cord-023168-cd7adns8	1043	41	is	be	VBZ
cord-023168-cd7adns8	1043	42	around	around	IN
cord-023168-cd7adns8	1043	43	4	4	CD
cord-023168-cd7adns8	1043	44	%	%	NN
cord-023168-cd7adns8	1043	45	.	.	.
cord-023168-cd7adns8	1044	1	268	268	CD
cord-023168-cd7adns8	1044	2	which	which	WDT
cord-023168-cd7adns8	1044	3	immediately	immediately	RB
cord-023168-cd7adns8	1044	4	limits	limit	VBZ
cord-023168-cd7adns8	1044	5	the	the	DT
cord-023168-cd7adns8	1044	6	amount	amount	NN
cord-023168-cd7adns8	1044	7	of	of	IN
cord-023168-cd7adns8	1044	8	blood	blood	NN
cord-023168-cd7adns8	1044	9	loss	loss	NN
cord-023168-cd7adns8	1044	10	.	.	.
cord-023168-cd7adns8	1045	1	Exposure	exposure	NN
cord-023168-cd7adns8	1045	2	of	of	IN
cord-023168-cd7adns8	1045	3	the	the	DT
cord-023168-cd7adns8	1045	4	subendothelial	subendothelial	JJ
cord-023168-cd7adns8	1045	5	space	space	NN
cord-023168-cd7adns8	1045	6	releases	release	NNS
cord-023168-cd7adns8	1045	7	factors	factor	NNS
cord-023168-cd7adns8	1045	8	such	such	JJ
cord-023168-cd7adns8	1045	9	as	as	IN
cord-023168-cd7adns8	1045	10	von	von	NNP
cord-023168-cd7adns8	1045	11	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1045	12	factor	factor	NN
cord-023168-cd7adns8	1045	13	multimers	multimer	NNS
cord-023168-cd7adns8	1045	14	which	which	WDT
cord-023168-cd7adns8	1045	15	bind	bind	VBP
cord-023168-cd7adns8	1045	16	to	to	IN
cord-023168-cd7adns8	1045	17	platelets	platelet	NNS
cord-023168-cd7adns8	1045	18	and	and	CC
cord-023168-cd7adns8	1045	19	initiate	initiate	VB
cord-023168-cd7adns8	1045	20	platelet	platelet	NN
cord-023168-cd7adns8	1045	21	adhesion	adhesion	NN
cord-023168-cd7adns8	1045	22	to	to	IN
cord-023168-cd7adns8	1045	23	the	the	DT
cord-023168-cd7adns8	1045	24	endothelium	endothelium	NN
cord-023168-cd7adns8	1045	25	.	.	.
cord-023168-cd7adns8	1046	1	The	the	DT
cord-023168-cd7adns8	1046	2	adherent	adherent	JJ
cord-023168-cd7adns8	1046	3	platelets	platelet	NNS
cord-023168-cd7adns8	1046	4	release	release	VBP
cord-023168-cd7adns8	1046	5	their	-PRON-	PRP$
cord-023168-cd7adns8	1046	6	granules	granule	NNS
cord-023168-cd7adns8	1046	7	and	and	CC
cord-023168-cd7adns8	1046	8	attract	attract	VB
cord-023168-cd7adns8	1046	9	more	more	JJR
cord-023168-cd7adns8	1046	10	platelets	platelet	NNS
cord-023168-cd7adns8	1046	11	,	,	,
cord-023168-cd7adns8	1046	12	which	which	WDT
cord-023168-cd7adns8	1046	13	in	in	IN
cord-023168-cd7adns8	1046	14	combination	combination	NN
cord-023168-cd7adns8	1046	15	with	with	IN
cord-023168-cd7adns8	1046	16	fibrinogen	fibrinogen	NN
cord-023168-cd7adns8	1046	17	,	,	,
cord-023168-cd7adns8	1046	18	form	form	VB
cord-023168-cd7adns8	1046	19	an	an	DT
cord-023168-cd7adns8	1046	20	aggregate	aggregate	NN
cord-023168-cd7adns8	1046	21	.	.	.
cord-023168-cd7adns8	1047	1	The	the	DT
cord-023168-cd7adns8	1047	2	activated	activate	VBN
cord-023168-cd7adns8	1047	3	platelets	platelet	NNS
cord-023168-cd7adns8	1047	4	also	also	RB
cord-023168-cd7adns8	1047	5	attract	attract	VBP
cord-023168-cd7adns8	1047	6	coagulation	coagulation	NN
cord-023168-cd7adns8	1047	7	factors	factor	NNS
cord-023168-cd7adns8	1047	8	thereby	thereby	RB
cord-023168-cd7adns8	1047	9	promoting	promote	VBG
cord-023168-cd7adns8	1047	10	the	the	DT
cord-023168-cd7adns8	1047	11	clotting	clotting	NN
cord-023168-cd7adns8	1047	12	process	process	NN
cord-023168-cd7adns8	1047	13	.	.	.
cord-023168-cd7adns8	1048	1	The	the	DT
cord-023168-cd7adns8	1048	2	critical	critical	JJ
cord-023168-cd7adns8	1048	3	parts	part	NNS
cord-023168-cd7adns8	1048	4	of	of	IN
cord-023168-cd7adns8	1048	5	clot	clot	NN
cord-023168-cd7adns8	1048	6	formation	formation	NN
cord-023168-cd7adns8	1048	7	are	be	VBP
cord-023168-cd7adns8	1048	8	the	the	DT
cord-023168-cd7adns8	1048	9	conversion	conversion	NN
cord-023168-cd7adns8	1048	10	of	of	IN
cord-023168-cd7adns8	1048	11	prothrombin	prothrombin	NN
cord-023168-cd7adns8	1048	12	to	to	IN
cord-023168-cd7adns8	1048	13	thrombin	thrombin	NN
cord-023168-cd7adns8	1048	14	and	and	CC
cord-023168-cd7adns8	1048	15	the	the	DT
cord-023168-cd7adns8	1048	16	thrombinfacilitated	thrombinfacilitated	JJ
cord-023168-cd7adns8	1048	17	conversion	conversion	NN
cord-023168-cd7adns8	1048	18	of	of	IN
cord-023168-cd7adns8	1048	19	fibrinogen	fibrinogen	NN
cord-023168-cd7adns8	1048	20	to	to	IN
cord-023168-cd7adns8	1048	21	fibrin	fibrin	NN
cord-023168-cd7adns8	1048	22	(	(	-LRB-
cord-023168-cd7adns8	1048	23	Figure	figure	NN
cord-023168-cd7adns8	1048	24	65.13	65.13	CD
cord-023168-cd7adns8	1048	25	)	)	-RRB-
cord-023168-cd7adns8	1048	26	.	.	.
cord-023168-cd7adns8	1049	1	Haemostatic	haemostatic	JJ
cord-023168-cd7adns8	1049	2	control	control	NN
cord-023168-cd7adns8	1049	3	mechanisms	mechanism	NNS
cord-023168-cd7adns8	1049	4	operate	operate	VBP
cord-023168-cd7adns8	1049	5	throughout	throughout	IN
cord-023168-cd7adns8	1049	6	the	the	DT
cord-023168-cd7adns8	1049	7	clotting	clotting	NN
cord-023168-cd7adns8	1049	8	process	process	NN
cord-023168-cd7adns8	1049	9	to	to	TO
cord-023168-cd7adns8	1049	10	prevent	prevent	VB
cord-023168-cd7adns8	1049	11	excessive	excessive	JJ
cord-023168-cd7adns8	1049	12	clot	clot	NN
cord-023168-cd7adns8	1049	13	formation	formation	NN
cord-023168-cd7adns8	1049	14	and	and	CC
cord-023168-cd7adns8	1049	15	involve	involve	VBP
cord-023168-cd7adns8	1049	16	proteins	protein	NNS
cord-023168-cd7adns8	1049	17	C	C	NNP
cord-023168-cd7adns8	1049	18	and	and	CC
cord-023168-cd7adns8	1049	19	S	S	NNP
cord-023168-cd7adns8	1049	20	,	,	,
cord-023168-cd7adns8	1049	21	and	and	CC
cord-023168-cd7adns8	1049	22	anti	anti	JJ
cord-023168-cd7adns8	1049	23	-	-	JJ
cord-023168-cd7adns8	1049	24	thrombin	thrombin	JJ
cord-023168-cd7adns8	1049	25	and	and	CC
cord-023168-cd7adns8	1049	26	antifibrinolytic	antifibrinolytic	JJ
cord-023168-cd7adns8	1049	27	systems	system	NNS
cord-023168-cd7adns8	1049	28	.	.	.
cord-023168-cd7adns8	1050	1	Any	any	DT
cord-023168-cd7adns8	1050	2	alteration	alteration	NN
cord-023168-cd7adns8	1050	3	in	in	IN
cord-023168-cd7adns8	1050	4	these	these	DT
cord-023168-cd7adns8	1050	5	regulatory	regulatory	JJ
cord-023168-cd7adns8	1050	6	pathways	pathway	NNS
cord-023168-cd7adns8	1050	7	can	can	MD
cord-023168-cd7adns8	1050	8	lead	lead	VB
cord-023168-cd7adns8	1050	9	to	to	IN
cord-023168-cd7adns8	1050	10	either	either	CC
cord-023168-cd7adns8	1050	11	bleeding	bleeding	JJ
cord-023168-cd7adns8	1050	12	or	or	CC
cord-023168-cd7adns8	1050	13	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1050	14	complications	complication	NNS
cord-023168-cd7adns8	1050	15	.	.	.
cord-023168-cd7adns8	1051	1	Bleeding	bleed	VBG
cord-023168-cd7adns8	1051	2	can	can	MD
cord-023168-cd7adns8	1051	3	result	result	VB
cord-023168-cd7adns8	1051	4	from	from	IN
cord-023168-cd7adns8	1051	5	:	:	:
cord-023168-cd7adns8	1052	1	•	•	NNP
cord-023168-cd7adns8	1053	1	Inadequate	inadequate	JJ
cord-023168-cd7adns8	1053	2	vasoconstriction	vasoconstriction	NN
cord-023168-cd7adns8	1053	3	,	,	,
cord-023168-cd7adns8	1053	4	due	due	IN
cord-023168-cd7adns8	1053	5	to	to	IN
cord-023168-cd7adns8	1053	6	vascular	vascular	JJ
cord-023168-cd7adns8	1053	7	problems	problem	NNS
cord-023168-cd7adns8	1053	8	which	which	WDT
cord-023168-cd7adns8	1053	9	can	can	MD
cord-023168-cd7adns8	1053	10	be	be	VB
cord-023168-cd7adns8	1053	11	acquired	acquire	VBN
cord-023168-cd7adns8	1053	12	(	(	-LRB-
cord-023168-cd7adns8	1053	13	e.g.	e.g.	IN
cord-023168-cd7adns8	1053	14	viral	viral	JJ
cord-023168-cd7adns8	1053	15	haemorrhagic	haemorrhagic	JJ
cord-023168-cd7adns8	1053	16	fevers	fever	NNS
cord-023168-cd7adns8	1053	17	or	or	CC
cord-023168-cd7adns8	1053	18	immune	immune	JJ
cord-023168-cd7adns8	1053	19	vasculitis	vasculitis	NN
cord-023168-cd7adns8	1053	20	)	)	-RRB-
cord-023168-cd7adns8	1053	21	or	or	CC
cord-023168-cd7adns8	1053	22	congenital	congenital	JJ
cord-023168-cd7adns8	1053	23	(	(	-LRB-
cord-023168-cd7adns8	1053	24	e.g.	e.g.	RB
cord-023168-cd7adns8	1053	25	collagen	collagen	NN
cord-023168-cd7adns8	1053	26	vascular	vascular	JJ
cord-023168-cd7adns8	1053	27	disorders	disorder	NNS
cord-023168-cd7adns8	1053	28	)	)	-RRB-
cord-023168-cd7adns8	1054	1	•	•	NNP
cord-023168-cd7adns8	1055	1	Qualitative	qualitative	JJ
cord-023168-cd7adns8	1055	2	or	or	CC
cord-023168-cd7adns8	1055	3	quantitative	quantitative	JJ
cord-023168-cd7adns8	1055	4	abnormality	abnormality	NN
cord-023168-cd7adns8	1055	5	of	of	IN
cord-023168-cd7adns8	1055	6	von	von	NNP
cord-023168-cd7adns8	1055	7	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1055	8	factor	factor	NN
cord-023168-cd7adns8	1055	9	causing	cause	VBG
cord-023168-cd7adns8	1055	10	von	von	NNP
cord-023168-cd7adns8	1055	11	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1055	12	's	's	POS
cord-023168-cd7adns8	1055	13	disease	disease	NN
cord-023168-cd7adns8	1056	1	•	•	NNP
cord-023168-cd7adns8	1057	1	Decreased	decrease	VBN
cord-023168-cd7adns8	1057	2	number	number	NN
cord-023168-cd7adns8	1057	3	or	or	CC
cord-023168-cd7adns8	1057	4	function	function	NN
cord-023168-cd7adns8	1057	5	of	of	IN
cord-023168-cd7adns8	1057	6	platelets	platelet	NNS
cord-023168-cd7adns8	1057	7	which	which	WDT
cord-023168-cd7adns8	1057	8	can	can	MD
cord-023168-cd7adns8	1057	9	be	be	VB
cord-023168-cd7adns8	1057	10	either	either	CC
cord-023168-cd7adns8	1057	11	acquired	acquire	VBN
cord-023168-cd7adns8	1057	12	(	(	-LRB-
cord-023168-cd7adns8	1057	13	e.g.	e.g.	IN
cord-023168-cd7adns8	1057	14	aspirin	aspirin	NN
cord-023168-cd7adns8	1057	15	,	,	,
cord-023168-cd7adns8	1057	16	NSAIDs	NSAIDs	NNPS
cord-023168-cd7adns8	1057	17	)	)	-RRB-
cord-023168-cd7adns8	1057	18	or	or	CC
cord-023168-cd7adns8	1057	19	congenital	congenital	JJ
cord-023168-cd7adns8	1057	20	(	(	-LRB-
cord-023168-cd7adns8	1057	21	e.g.	e.g.	IN
cord-023168-cd7adns8	1057	22	platelet	platelet	NN
cord-023168-cd7adns8	1057	23	function	function	NN
cord-023168-cd7adns8	1057	24	defects	defect	NNS
cord-023168-cd7adns8	1057	25	)	)	-RRB-
cord-023168-cd7adns8	1058	1	•	•	NNP
cord-023168-cd7adns8	1059	1	Qualitative	qualitative	JJ
cord-023168-cd7adns8	1060	1	(	(	-LRB-
cord-023168-cd7adns8	1060	2	e.g.	e.g.	RB
cord-023168-cd7adns8	1060	3	caused	cause	VBN
cord-023168-cd7adns8	1060	4	by	by	IN
cord-023168-cd7adns8	1060	5	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1060	6	to	to	IN
cord-023168-cd7adns8	1060	7	coagulation	coagulation	NN
cord-023168-cd7adns8	1060	8	factors	factor	NNS
cord-023168-cd7adns8	1060	9	,	,	,
cord-023168-cd7adns8	1060	10	commonly	commonly	RB
cord-023168-cd7adns8	1060	11	factor	factor	NN
cord-023168-cd7adns8	1060	12	VIII	VIII	NNP
cord-023168-cd7adns8	1060	13	)	)	-RRB-
cord-023168-cd7adns8	1060	14	or	or	CC
cord-023168-cd7adns8	1060	15	quantitative	quantitative	JJ
cord-023168-cd7adns8	1060	16	(	(	-LRB-
cord-023168-cd7adns8	1060	17	e.g.	e.g.	IN
cord-023168-cd7adns8	1060	18	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1060	19	)	)	-RRB-
cord-023168-cd7adns8	1060	20	abnormality	abnormality	NN
cord-023168-cd7adns8	1060	21	of	of	IN
cord-023168-cd7adns8	1060	22	coagulation	coagulation	NN
cord-023168-cd7adns8	1060	23	factors	factor	NNS
cord-023168-cd7adns8	1061	1	•	•	NNP
cord-023168-cd7adns8	1062	1	Increased	increase	VBN
cord-023168-cd7adns8	1062	2	fibrinolysis	fibrinolysis	NN
cord-023168-cd7adns8	1062	3	(	(	-LRB-
cord-023168-cd7adns8	1062	4	e.g.	e.g.	DT
cord-023168-cd7adns8	1062	5	viral	viral	JJ
cord-023168-cd7adns8	1062	6	haemorrhagic	haemorrhagic	JJ
cord-023168-cd7adns8	1062	7	fevers	fever	NNS
cord-023168-cd7adns8	1062	8	,	,	,
cord-023168-cd7adns8	1062	9	snake	snake	NN
cord-023168-cd7adns8	1062	10	bites	bite	NNS
cord-023168-cd7adns8	1062	11	)	)	-RRB-
cord-023168-cd7adns8	1062	12	.	.	.
cord-023168-cd7adns8	1063	1	Acquired	acquire	VBN
cord-023168-cd7adns8	1063	2	bleeding	bleeding	NN
cord-023168-cd7adns8	1063	3	disorders	disorder	NNS
cord-023168-cd7adns8	1063	4	are	be	VBP
cord-023168-cd7adns8	1063	5	commonly	commonly	RB
cord-023168-cd7adns8	1063	6	caused	cause	VBN
cord-023168-cd7adns8	1063	7	by	by	IN
cord-023168-cd7adns8	1063	8	vitamin	vitamin	NN
cord-023168-cd7adns8	1063	9	K	K	NNP
cord-023168-cd7adns8	1063	10	deficiency	deficiency	NN
cord-023168-cd7adns8	1063	11	,	,	,
cord-023168-cd7adns8	1063	12	disseminated	disseminate	VBN
cord-023168-cd7adns8	1063	13	intravascular	intravascular	JJ
cord-023168-cd7adns8	1063	14	coagulation	coagulation	NN
cord-023168-cd7adns8	1063	15	(	(	-LRB-
cord-023168-cd7adns8	1063	16	DIC	DIC	NNP
cord-023168-cd7adns8	1063	17	)	)	-RRB-
cord-023168-cd7adns8	1063	18	or	or	CC
cord-023168-cd7adns8	1063	19	platelet	platelet	NN
cord-023168-cd7adns8	1063	20	disorders	disorder	NNS
cord-023168-cd7adns8	1063	21	(	(	-LRB-
cord-023168-cd7adns8	1063	22	Box	Box	NNP
cord-023168-cd7adns8	1063	23	65.19	65.19	CD
cord-023168-cd7adns8	1063	24	)	)	-RRB-
cord-023168-cd7adns8	1064	1	but	but	CC
cord-023168-cd7adns8	1064	2	may	may	MD
cord-023168-cd7adns8	1064	3	sometimes	sometimes	RB
cord-023168-cd7adns8	1064	4	be	be	VB
cord-023168-cd7adns8	1064	5	due	due	JJ
cord-023168-cd7adns8	1064	6	to	to	IN
cord-023168-cd7adns8	1064	7	acquired	acquire	VBN
cord-023168-cd7adns8	1064	8	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1064	9	of	of	IN
cord-023168-cd7adns8	1064	10	coagulation	coagulation	NN
cord-023168-cd7adns8	1064	11	factors	factor	NNS
cord-023168-cd7adns8	1064	12	.	.	.
cord-023168-cd7adns8	1065	1	The	the	DT
cord-023168-cd7adns8	1065	2	initial	initial	JJ
cord-023168-cd7adns8	1065	3	laboratory	laboratory	NN
cord-023168-cd7adns8	1065	4	tests	test	NNS
cord-023168-cd7adns8	1065	5	in	in	IN
cord-023168-cd7adns8	1065	6	a	a	DT
cord-023168-cd7adns8	1065	7	patient	patient	NN
cord-023168-cd7adns8	1065	8	with	with	IN
cord-023168-cd7adns8	1065	9	excessive	excessive	JJ
cord-023168-cd7adns8	1065	10	bleeding	bleeding	NN
cord-023168-cd7adns8	1065	11	should	should	MD
cord-023168-cd7adns8	1065	12	therefore	therefore	RB
cord-023168-cd7adns8	1065	13	include	include	VB
cord-023168-cd7adns8	1065	14	a	a	DT
cord-023168-cd7adns8	1065	15	platelet	platelet	NN
cord-023168-cd7adns8	1065	16	count	count	NN
cord-023168-cd7adns8	1065	17	,	,	,
cord-023168-cd7adns8	1065	18	clotting	clot	VBG
cord-023168-cd7adns8	1065	19	screen	screen	NN
cord-023168-cd7adns8	1065	20	(	(	-LRB-
cord-023168-cd7adns8	1065	21	prothrombin	prothrombin	NN
cord-023168-cd7adns8	1065	22	time	time	NN
cord-023168-cd7adns8	1065	23	(	(	-LRB-
cord-023168-cd7adns8	1065	24	PT	PT	NNP
cord-023168-cd7adns8	1065	25	)	)	-RRB-
cord-023168-cd7adns8	1065	26	and	and	CC
cord-023168-cd7adns8	1065	27	activated	activate	VBD
cord-023168-cd7adns8	1065	28	partial	partial	JJ
cord-023168-cd7adns8	1065	29	thromboplastin	thromboplastin	NNP
cord-023168-cd7adns8	1065	30	time	time	NN
cord-023168-cd7adns8	1065	31	(	(	-LRB-
cord-023168-cd7adns8	1065	32	aPTT	aptt	NN
cord-023168-cd7adns8	1065	33	)	)	-RRB-
cord-023168-cd7adns8	1065	34	)	)	-RRB-
cord-023168-cd7adns8	1065	35	,	,	,
cord-023168-cd7adns8	1065	36	and	and	CC
cord-023168-cd7adns8	1065	37	gastrointestinal	gastrointestinal	JJ
cord-023168-cd7adns8	1065	38	tract	tract	NN
cord-023168-cd7adns8	1065	39	,	,	,
cord-023168-cd7adns8	1065	40	often	often	RB
cord-023168-cd7adns8	1065	41	the	the	DT
cord-023168-cd7adns8	1065	42	stomach	stomach	NN
cord-023168-cd7adns8	1065	43	or	or	CC
cord-023168-cd7adns8	1065	44	the	the	DT
cord-023168-cd7adns8	1065	45	perianal	perianal	JJ
cord-023168-cd7adns8	1065	46	region	region	NN
cord-023168-cd7adns8	1065	47	.	.	.
cord-023168-cd7adns8	1066	1	283	283	CD
cord-023168-cd7adns8	1066	2	Hepatic	hepatic	JJ
cord-023168-cd7adns8	1066	3	involvement	involvement	NN
cord-023168-cd7adns8	1066	4	,	,	,
cord-023168-cd7adns8	1066	5	seen	see	VBN
cord-023168-cd7adns8	1066	6	in	in	IN
cord-023168-cd7adns8	1066	7	a	a	DT
cord-023168-cd7adns8	1066	8	quarter	quarter	NN
cord-023168-cd7adns8	1066	9	of	of	IN
cord-023168-cd7adns8	1066	10	cases	case	NNS
cord-023168-cd7adns8	1066	11	,	,	,
cord-023168-cd7adns8	1066	12	is	be	VBZ
cord-023168-cd7adns8	1066	13	associated	associate	VBN
cord-023168-cd7adns8	1066	14	with	with	IN
cord-023168-cd7adns8	1066	15	a	a	DT
cord-023168-cd7adns8	1066	16	particularly	particularly	RB
cord-023168-cd7adns8	1066	17	poor	poor	JJ
cord-023168-cd7adns8	1066	18	prognosis	prognosis	NN
cord-023168-cd7adns8	1066	19	.	.	.
cord-023168-cd7adns8	1067	1	CNS	CNS	NNP
cord-023168-cd7adns8	1067	2	disease	disease	NN
cord-023168-cd7adns8	1067	3	may	may	MD
cord-023168-cd7adns8	1067	4	be	be	VB
cord-023168-cd7adns8	1067	5	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	1068	1	so	so	RB
cord-023168-cd7adns8	1068	2	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	1068	3	lumbar	lumbar	NN
cord-023168-cd7adns8	1068	4	puncture	puncture	NN
cord-023168-cd7adns8	1068	5	may	may	MD
cord-023168-cd7adns8	1068	6	be	be	VB
cord-023168-cd7adns8	1068	7	required	require	VBN
cord-023168-cd7adns8	1068	8	.	.	.
cord-023168-cd7adns8	1069	1	284	284	CD
cord-023168-cd7adns8	1069	2	HIV	HIV	NNP
cord-023168-cd7adns8	1069	3	-	-	HYPH
cord-023168-cd7adns8	1069	4	related	relate	VBN
cord-023168-cd7adns8	1069	5	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1069	6	frequently	frequently	RB
cord-023168-cd7adns8	1069	7	present	present	JJ
cord-023168-cd7adns8	1069	8	with	with	IN
cord-023168-cd7adns8	1069	9	poor	poor	JJ
cord-023168-cd7adns8	1069	10	prognostic	prognostic	JJ
cord-023168-cd7adns8	1069	11	features	feature	NNS
cord-023168-cd7adns8	1069	12	such	such	JJ
cord-023168-cd7adns8	1069	13	as	as	IN
cord-023168-cd7adns8	1069	14	elevated	elevated	JJ
cord-023168-cd7adns8	1069	15	serum	serum	NN
cord-023168-cd7adns8	1069	16	lactate	lactate	NN
cord-023168-cd7adns8	1069	17	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1069	18	levels	level	NNS
cord-023168-cd7adns8	1069	19	.	.	.
cord-023168-cd7adns8	1070	1	285	285	CD
cord-023168-cd7adns8	1070	2	,	,	,
cord-023168-cd7adns8	1070	3	286	286	CD
cord-023168-cd7adns8	1070	4	Older	old	JJR
cord-023168-cd7adns8	1070	5	age	age	NN
cord-023168-cd7adns8	1070	6	,	,	,
cord-023168-cd7adns8	1070	7	lowest	low	JJS
cord-023168-cd7adns8	1070	8	nadir	nadir	NN
cord-023168-cd7adns8	1070	9	CD4	CD4	NNP
cord-023168-cd7adns8	1070	10	cell	cell	NN
cord-023168-cd7adns8	1070	11	counts	count	VBZ
cord-023168-cd7adns8	1070	12	prior	prior	RB
cord-023168-cd7adns8	1070	13	to	to	IN
cord-023168-cd7adns8	1070	14	NHL	NHL	NNP
cord-023168-cd7adns8	1070	15	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1070	16	,	,	,
cord-023168-cd7adns8	1070	17	developing	develop	VBG
cord-023168-cd7adns8	1070	18	NHL	NHL	NNP
cord-023168-cd7adns8	1070	19	while	while	IN
cord-023168-cd7adns8	1070	20	on	on	IN
cord-023168-cd7adns8	1070	21	ART	art	NN
cord-023168-cd7adns8	1070	22	,	,	,
cord-023168-cd7adns8	1070	23	and	and	CC
cord-023168-cd7adns8	1070	24	cumulative	cumulative	JJ
cord-023168-cd7adns8	1070	25	HIV	HIV	NNP
cord-023168-cd7adns8	1070	26	viraemia	viraemia	NN
cord-023168-cd7adns8	1070	27	are	be	VBP
cord-023168-cd7adns8	1070	28	also	also	RB
cord-023168-cd7adns8	1070	29	poor	poor	JJ
cord-023168-cd7adns8	1070	30	prognostic	prognostic	JJ
cord-023168-cd7adns8	1070	31	features	feature	NNS
cord-023168-cd7adns8	1070	32	.	.	.
cord-023168-cd7adns8	1071	1	282	282	CD
cord-023168-cd7adns8	1071	2	A	a	DT
cord-023168-cd7adns8	1071	3	formal	formal	JJ
cord-023168-cd7adns8	1071	4	prognostic	prognostic	JJ
cord-023168-cd7adns8	1071	5	scoring	scoring	NN
cord-023168-cd7adns8	1071	6	system	system	NN
cord-023168-cd7adns8	1071	7	has	have	VBZ
cord-023168-cd7adns8	1071	8	been	be	VBN
cord-023168-cd7adns8	1071	9	developed	develop	VBN
cord-023168-cd7adns8	1071	10	which	which	WDT
cord-023168-cd7adns8	1071	11	takes	take	VBZ
cord-023168-cd7adns8	1071	12	into	into	IN
cord-023168-cd7adns8	1071	13	account	account	NN
cord-023168-cd7adns8	1071	14	the	the	DT
cord-023168-cd7adns8	1071	15	CD4	CD4	NNP
cord-023168-cd7adns8	1071	16	count	count	VB
cord-023168-cd7adns8	1071	17	(	(	-LRB-
cord-023168-cd7adns8	1071	18	<	<	NNP
cord-023168-cd7adns8	1071	19	100	100	CD
cord-023168-cd7adns8	1071	20	cells/µL	cells/µL	NNP
cord-023168-cd7adns8	1071	21	)	)	-RRB-
cord-023168-cd7adns8	1071	22	.	.	.
cord-023168-cd7adns8	1072	1	287	287	CD
cord-023168-cd7adns8	1073	1	Some	some	DT
cord-023168-cd7adns8	1073	2	types	type	NNS
cord-023168-cd7adns8	1073	3	of	of	IN
cord-023168-cd7adns8	1073	4	HIV	HIV	NNP
cord-023168-cd7adns8	1073	5	-	-	HYPH
cord-023168-cd7adns8	1073	6	related	relate	VBN
cord-023168-cd7adns8	1073	7	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1073	8	are	be	VBP
cord-023168-cd7adns8	1073	9	associated	associate	VBN
cord-023168-cd7adns8	1073	10	with	with	IN
cord-023168-cd7adns8	1073	11	characteristic	characteristic	JJ
cord-023168-cd7adns8	1073	12	clinical	clinical	JJ
cord-023168-cd7adns8	1073	13	and	and	CC
cord-023168-cd7adns8	1073	14	laboratory	laboratory	NN
cord-023168-cd7adns8	1073	15	features	feature	NNS
cord-023168-cd7adns8	1073	16	.	.	.
cord-023168-cd7adns8	1074	1	Primary	primary	JJ
cord-023168-cd7adns8	1074	2	effusion	effusion	NN
cord-023168-cd7adns8	1074	3	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1074	4	is	be	VBZ
cord-023168-cd7adns8	1074	5	an	an	DT
cord-023168-cd7adns8	1074	6	aggressive	aggressive	JJ
cord-023168-cd7adns8	1074	7	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1074	8	characterized	characterize	VBN
cord-023168-cd7adns8	1074	9	by	by	IN
cord-023168-cd7adns8	1074	10	effusions	effusion	NNS
cord-023168-cd7adns8	1074	11	in	in	IN
cord-023168-cd7adns8	1074	12	serosal	serosal	NN
cord-023168-cd7adns8	1074	13	cavities	cavity	NNS
cord-023168-cd7adns8	1074	14	in	in	IN
cord-023168-cd7adns8	1074	15	the	the	DT
cord-023168-cd7adns8	1074	16	absence	absence	NN
cord-023168-cd7adns8	1074	17	of	of	IN
cord-023168-cd7adns8	1074	18	any	any	DT
cord-023168-cd7adns8	1074	19	other	other	JJ
cord-023168-cd7adns8	1074	20	tumour	tumour	NN
cord-023168-cd7adns8	1074	21	masses	masse	NNS
cord-023168-cd7adns8	1074	22	.	.	.
cord-023168-cd7adns8	1075	1	288	288	CD
cord-023168-cd7adns8	1075	2	,	,	,
cord-023168-cd7adns8	1075	3	289	289	CD
cord-023168-cd7adns8	1076	1	It	-PRON-	PRP
cord-023168-cd7adns8	1076	2	is	be	VBZ
cord-023168-cd7adns8	1076	3	strongly	strongly	RB
cord-023168-cd7adns8	1076	4	associated	associate	VBN
cord-023168-cd7adns8	1076	5	with	with	IN
cord-023168-cd7adns8	1076	6	HHV8	HHV8	NNP
cord-023168-cd7adns8	1076	7	infection	infection	NN
cord-023168-cd7adns8	1076	8	and	and	CC
cord-023168-cd7adns8	1076	9	the	the	DT
cord-023168-cd7adns8	1076	10	virus	virus	NN
cord-023168-cd7adns8	1076	11	can	can	MD
cord-023168-cd7adns8	1076	12	be	be	VB
cord-023168-cd7adns8	1076	13	identified	identify	VBN
cord-023168-cd7adns8	1076	14	in	in	IN
cord-023168-cd7adns8	1076	15	the	the	DT
cord-023168-cd7adns8	1076	16	nuclei	nucleus	NNS
cord-023168-cd7adns8	1076	17	of	of	IN
cord-023168-cd7adns8	1076	18	the	the	DT
cord-023168-cd7adns8	1076	19	malignant	malignant	JJ
cord-023168-cd7adns8	1076	20	cells	cell	NNS
cord-023168-cd7adns8	1076	21	.	.	.
cord-023168-cd7adns8	1077	1	Plasmablastic	plasmablastic	JJ
cord-023168-cd7adns8	1077	2	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1077	3	mainly	mainly	RB
cord-023168-cd7adns8	1077	4	affects	affect	VBZ
cord-023168-cd7adns8	1077	5	the	the	DT
cord-023168-cd7adns8	1077	6	oral	oral	JJ
cord-023168-cd7adns8	1077	7	cavity	cavity	NN
cord-023168-cd7adns8	1077	8	and	and	CC
cord-023168-cd7adns8	1077	9	the	the	DT
cord-023168-cd7adns8	1077	10	mucosa	mucosa	NN
cord-023168-cd7adns8	1077	11	of	of	IN
cord-023168-cd7adns8	1077	12	the	the	DT
cord-023168-cd7adns8	1077	13	jaw	jaw	NN
cord-023168-cd7adns8	1077	14	and	and	CC
cord-023168-cd7adns8	1077	15	is	be	VBZ
cord-023168-cd7adns8	1077	16	typically	typically	RB
cord-023168-cd7adns8	1077	17	associated	associate	VBN
cord-023168-cd7adns8	1077	18	with	with	IN
cord-023168-cd7adns8	1077	19	Epstein	Epstein	NNP
cord-023168-cd7adns8	1077	20	-	-	HYPH
cord-023168-cd7adns8	1077	21	Barr	Barr	NNP
cord-023168-cd7adns8	1077	22	virus	virus	NN
cord-023168-cd7adns8	1077	23	.	.	.
cord-023168-cd7adns8	1078	1	290	290	CD
cord-023168-cd7adns8	1078	2	Histological	Histological	NNP
cord-023168-cd7adns8	1078	3	examination	examination	NN
cord-023168-cd7adns8	1078	4	of	of	IN
cord-023168-cd7adns8	1078	5	biopsied	biopsie	VBN
cord-023168-cd7adns8	1078	6	tissue	tissue	NN
cord-023168-cd7adns8	1078	7	is	be	VBZ
cord-023168-cd7adns8	1078	8	necessary	necessary	JJ
cord-023168-cd7adns8	1078	9	to	to	TO
cord-023168-cd7adns8	1078	10	confirm	confirm	VB
cord-023168-cd7adns8	1078	11	the	the	DT
cord-023168-cd7adns8	1078	12	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1078	13	and	and	CC
cord-023168-cd7adns8	1078	14	type	type	NN
cord-023168-cd7adns8	1078	15	of	of	IN
cord-023168-cd7adns8	1078	16	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1078	17	.	.	.
cord-023168-cd7adns8	1079	1	Diagnostic	diagnostic	JJ
cord-023168-cd7adns8	1079	2	difficulties	difficulty	NNS
cord-023168-cd7adns8	1079	3	may	may	MD
cord-023168-cd7adns8	1079	4	arise	arise	VB
cord-023168-cd7adns8	1079	5	because	because	IN
cord-023168-cd7adns8	1079	6	HIV	HIV	NNP
cord-023168-cd7adns8	1079	7	-	-	HYPH
cord-023168-cd7adns8	1079	8	related	relate	VBN
cord-023168-cd7adns8	1079	9	hyperplasia	hyperplasia	NN
cord-023168-cd7adns8	1079	10	in	in	IN
cord-023168-cd7adns8	1079	11	lymph	lymph	NN
cord-023168-cd7adns8	1079	12	node	node	NN
cord-023168-cd7adns8	1079	13	biopsies	biopsy	NNS
cord-023168-cd7adns8	1079	14	may	may	MD
cord-023168-cd7adns8	1079	15	be	be	VB
cord-023168-cd7adns8	1079	16	confused	confuse	VBN
cord-023168-cd7adns8	1079	17	with	with	IN
cord-023168-cd7adns8	1079	18	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1079	19	,	,	,
cord-023168-cd7adns8	1079	20	the	the	DT
cord-023168-cd7adns8	1079	21	histological	histological	JJ
cord-023168-cd7adns8	1079	22	appearance	appearance	NN
cord-023168-cd7adns8	1079	23	of	of	IN
cord-023168-cd7adns8	1079	24	HIV	HIV	NNP
cord-023168-cd7adns8	1079	25	-	-	HYPH
cord-023168-cd7adns8	1079	26	related	relate	VBN
cord-023168-cd7adns8	1079	27	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1079	28	may	may	MD
cord-023168-cd7adns8	1079	29	be	be	VB
cord-023168-cd7adns8	1079	30	different	different	JJ
cord-023168-cd7adns8	1079	31	from	from	IN
cord-023168-cd7adns8	1079	32	those	those	DT
cord-023168-cd7adns8	1079	33	of	of	IN
cord-023168-cd7adns8	1079	34	non	non	JJ
cord-023168-cd7adns8	1079	35	-	-	JJ
cord-023168-cd7adns8	1079	36	infected	infected	JJ
cord-023168-cd7adns8	1079	37	individuals	individual	NNS
cord-023168-cd7adns8	1079	38	291	291	CD
cord-023168-cd7adns8	1079	39	and	and	CC
cord-023168-cd7adns8	1079	40	many	many	JJ
cord-023168-cd7adns8	1079	41	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	1079	42	pathogens	pathogen	NNS
cord-023168-cd7adns8	1079	43	may	may	MD
cord-023168-cd7adns8	1079	44	mimic	mimic	VB
cord-023168-cd7adns8	1079	45	the	the	DT
cord-023168-cd7adns8	1079	46	appearances	appearance	NNS
cord-023168-cd7adns8	1079	47	of	of	IN
cord-023168-cd7adns8	1079	48	NHL	NHL	NNP
cord-023168-cd7adns8	1079	49	,	,	,
cord-023168-cd7adns8	1079	50	or	or	CC
cord-023168-cd7adns8	1079	51	co	co	NNS
cord-023168-cd7adns8	1079	52	-	-	NN
cord-023168-cd7adns8	1079	53	exist	exist	VB
cord-023168-cd7adns8	1079	54	with	with	IN
cord-023168-cd7adns8	1079	55	it	-PRON-	PRP
cord-023168-cd7adns8	1079	56	,	,	,
cord-023168-cd7adns8	1079	57	and	and	CC
cord-023168-cd7adns8	1079	58	will	will	MD
cord-023168-cd7adns8	1079	59	need	need	VB
cord-023168-cd7adns8	1079	60	to	to	TO
cord-023168-cd7adns8	1079	61	be	be	VB
cord-023168-cd7adns8	1079	62	identified	identify	VBN
cord-023168-cd7adns8	1079	63	or	or	CC
cord-023168-cd7adns8	1079	64	excluded	exclude	VBN
cord-023168-cd7adns8	1079	65	before	before	IN
cord-023168-cd7adns8	1079	66	making	make	VBG
cord-023168-cd7adns8	1079	67	a	a	DT
cord-023168-cd7adns8	1079	68	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1079	69	of	of	IN
cord-023168-cd7adns8	1079	70	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1079	71	.	.	.
cord-023168-cd7adns8	1080	1	Prior	prior	RB
cord-023168-cd7adns8	1080	2	to	to	IN
cord-023168-cd7adns8	1080	3	the	the	DT
cord-023168-cd7adns8	1080	4	widespread	widespread	JJ
cord-023168-cd7adns8	1080	5	use	use	NN
cord-023168-cd7adns8	1080	6	of	of	IN
cord-023168-cd7adns8	1080	7	ART	art	NN
cord-023168-cd7adns8	1080	8	,	,	,
cord-023168-cd7adns8	1080	9	conventional	conventional	JJ
cord-023168-cd7adns8	1080	10	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1080	11	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1080	12	resulted	result	VBD
cord-023168-cd7adns8	1080	13	in	in	IN
cord-023168-cd7adns8	1080	14	considerable	considerable	JJ
cord-023168-cd7adns8	1080	15	toxicity	toxicity	NN
cord-023168-cd7adns8	1080	16	,	,	,
cord-023168-cd7adns8	1080	17	increased	increase	VBN
cord-023168-cd7adns8	1080	18	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	1080	19	infections	infection	NNS
cord-023168-cd7adns8	1080	20	and	and	CC
cord-023168-cd7adns8	1080	21	high	high	JJ
cord-023168-cd7adns8	1080	22	mortality	mortality	NN
cord-023168-cd7adns8	1080	23	.	.	.
cord-023168-cd7adns8	1081	1	ART	art	NN
cord-023168-cd7adns8	1081	2	has	have	VBZ
cord-023168-cd7adns8	1081	3	facilitated	facilitate	VBN
cord-023168-cd7adns8	1081	4	the	the	DT
cord-023168-cd7adns8	1081	5	use	use	NN
cord-023168-cd7adns8	1081	6	of	of	IN
cord-023168-cd7adns8	1081	7	conventional	conventional	JJ
cord-023168-cd7adns8	1081	8	doses	dose	NNS
cord-023168-cd7adns8	1081	9	of	of	IN
cord-023168-cd7adns8	1081	10	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1081	11	in	in	IN
cord-023168-cd7adns8	1081	12	conjunction	conjunction	NN
cord-023168-cd7adns8	1081	13	with	with	IN
cord-023168-cd7adns8	1081	14	haematopoietic	haematopoietic	JJ
cord-023168-cd7adns8	1081	15	growth	growth	NN
cord-023168-cd7adns8	1081	16	factor	factor	NN
cord-023168-cd7adns8	1081	17	support	support	NN
cord-023168-cd7adns8	1081	18	.	.	.
cord-023168-cd7adns8	1082	1	This	this	DT
cord-023168-cd7adns8	1082	2	has	have	VBZ
cord-023168-cd7adns8	1082	3	markedly	markedly	RB
cord-023168-cd7adns8	1082	4	improved	improve	VBN
cord-023168-cd7adns8	1082	5	the	the	DT
cord-023168-cd7adns8	1082	6	outcome	outcome	NN
cord-023168-cd7adns8	1082	7	of	of	IN
cord-023168-cd7adns8	1082	8	patients	patient	NNS
cord-023168-cd7adns8	1082	9	with	with	IN
cord-023168-cd7adns8	1082	10	HIV	HIV	NNP
cord-023168-cd7adns8	1082	11	-	-	HYPH
cord-023168-cd7adns8	1082	12	related	relate	VBN
cord-023168-cd7adns8	1082	13	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1082	14	who	who	WP
cord-023168-cd7adns8	1082	15	now	now	RB
cord-023168-cd7adns8	1082	16	have	have	VBP
cord-023168-cd7adns8	1082	17	overall	overall	JJ
cord-023168-cd7adns8	1082	18	response	response	NN
cord-023168-cd7adns8	1082	19	rates	rate	NNS
cord-023168-cd7adns8	1082	20	of	of	IN
cord-023168-cd7adns8	1082	21	60	60	CD
cord-023168-cd7adns8	1082	22	%	%	NN
cord-023168-cd7adns8	1082	23	.	.	.
cord-023168-cd7adns8	1083	1	292	292	CD
cord-023168-cd7adns8	1084	1	The	the	DT
cord-023168-cd7adns8	1084	2	concomitant	concomitant	JJ
cord-023168-cd7adns8	1084	3	use	use	NN
cord-023168-cd7adns8	1084	4	of	of	IN
cord-023168-cd7adns8	1084	5	ART	art	NN
cord-023168-cd7adns8	1084	6	and	and	CC
cord-023168-cd7adns8	1084	7	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1084	8	is	be	VBZ
cord-023168-cd7adns8	1084	9	therefore	therefore	RB
cord-023168-cd7adns8	1084	10	recommended	recommend	VBN
cord-023168-cd7adns8	1084	11	,	,	,
cord-023168-cd7adns8	1084	12	especially	especially	RB
cord-023168-cd7adns8	1084	13	in	in	IN
cord-023168-cd7adns8	1084	14	those	those	DT
cord-023168-cd7adns8	1084	15	with	with	IN
cord-023168-cd7adns8	1084	16	CD4	CD4	NNP
cord-023168-cd7adns8	1084	17	counts	count	VBZ
cord-023168-cd7adns8	1084	18	of	of	IN
cord-023168-cd7adns8	1084	19	less	less	JJR
cord-023168-cd7adns8	1084	20	than	than	IN
cord-023168-cd7adns8	1084	21	100/µL.	100/µL.	NNP
cord-023168-cd7adns8	1084	22	Anti	Anti	NNP
cord-023168-cd7adns8	1084	23	-	-	NNP
cord-023168-cd7adns8	1084	24	CD20	CD20	NNP
cord-023168-cd7adns8	1084	25	antibody	antibody	NN
cord-023168-cd7adns8	1084	26	is	be	VBZ
cord-023168-cd7adns8	1084	27	now	now	RB
cord-023168-cd7adns8	1084	28	included	include	VBN
cord-023168-cd7adns8	1084	29	in	in	IN
cord-023168-cd7adns8	1084	30	treatment	treatment	NN
cord-023168-cd7adns8	1084	31	regimens	regimen	NNS
cord-023168-cd7adns8	1084	32	for	for	IN
cord-023168-cd7adns8	1084	33	NHL	NHL	NNP
cord-023168-cd7adns8	1084	34	,	,	,
cord-023168-cd7adns8	1084	35	and	and	CC
cord-023168-cd7adns8	1084	36	studies	study	NNS
cord-023168-cd7adns8	1084	37	that	that	WDT
cord-023168-cd7adns8	1084	38	include	include	VBP
cord-023168-cd7adns8	1084	39	patients	patient	NNS
cord-023168-cd7adns8	1084	40	with	with	IN
cord-023168-cd7adns8	1084	41	HIVrelated	HIVrelated	NNP
cord-023168-cd7adns8	1084	42	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1084	43	all	all	DT
cord-023168-cd7adns8	1084	44	report	report	VBP
cord-023168-cd7adns8	1084	45	favourable	favourable	JJ
cord-023168-cd7adns8	1084	46	outcomes	outcome	NNS
cord-023168-cd7adns8	1084	47	.	.	.
cord-023168-cd7adns8	1085	1	293	293	CD
cord-023168-cd7adns8	1085	2	,	,	,
cord-023168-cd7adns8	1085	3	294	294	CD
cord-023168-cd7adns8	1086	1	Some	some	DT
cord-023168-cd7adns8	1086	2	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1086	3	agents	agent	NNS
cord-023168-cd7adns8	1086	4	such	such	JJ
cord-023168-cd7adns8	1086	5	as	as	IN
cord-023168-cd7adns8	1086	6	zidovudine	zidovudine	NN
cord-023168-cd7adns8	1086	7	are	be	VBP
cord-023168-cd7adns8	1086	8	best	well	RBS
cord-023168-cd7adns8	1086	9	avoided	avoid	VBN
cord-023168-cd7adns8	1086	10	in	in	IN
cord-023168-cd7adns8	1086	11	combination	combination	NN
cord-023168-cd7adns8	1086	12	with	with	IN
cord-023168-cd7adns8	1086	13	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1086	14	,	,	,
cord-023168-cd7adns8	1086	15	because	because	IN
cord-023168-cd7adns8	1086	16	it	-PRON-	PRP
cord-023168-cd7adns8	1086	17	adds	add	VBZ
cord-023168-cd7adns8	1086	18	to	to	IN
cord-023168-cd7adns8	1086	19	the	the	DT
cord-023168-cd7adns8	1086	20	myelosuppression	myelosuppression	NN
cord-023168-cd7adns8	1086	21	of	of	IN
cord-023168-cd7adns8	1086	22	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1086	23	.	.	.
cord-023168-cd7adns8	1087	1	Didanosine	Didanosine	NNP
cord-023168-cd7adns8	1087	2	may	may	MD
cord-023168-cd7adns8	1087	3	worsen	worsen	VB
cord-023168-cd7adns8	1087	4	the	the	DT
cord-023168-cd7adns8	1087	5	peripheral	peripheral	JJ
cord-023168-cd7adns8	1087	6	neuropathy	neuropathy	NN
cord-023168-cd7adns8	1087	7	caused	cause	VBN
cord-023168-cd7adns8	1087	8	by	by	IN
cord-023168-cd7adns8	1087	9	taxanes	taxane	NNS
cord-023168-cd7adns8	1087	10	and	and	CC
cord-023168-cd7adns8	1087	11	vinca	vinca	NNP
cord-023168-cd7adns8	1087	12	alkaloids	alkaloid	NNS
cord-023168-cd7adns8	1087	13	.	.	.
cord-023168-cd7adns8	1088	1	HIV	HIV	NNP
cord-023168-cd7adns8	1088	2	-	-	HYPH
cord-023168-cd7adns8	1088	3	infected	infect	VBN
cord-023168-cd7adns8	1088	4	patients	patient	NNS
cord-023168-cd7adns8	1088	5	undergoing	undergo	VBG
cord-023168-cd7adns8	1088	6	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1088	7	should	should	MD
cord-023168-cd7adns8	1088	8	receive	receive	VB
cord-023168-cd7adns8	1088	9	adequate	adequate	JJ
cord-023168-cd7adns8	1088	10	anti	anti	JJ
cord-023168-cd7adns8	1088	11	-	-	JJ
cord-023168-cd7adns8	1088	12	infective	infective	JJ
cord-023168-cd7adns8	1088	13	prophylaxis	prophylaxis	NN
cord-023168-cd7adns8	1088	14	due	due	IN
cord-023168-cd7adns8	1088	15	to	to	IN
cord-023168-cd7adns8	1088	16	the	the	DT
cord-023168-cd7adns8	1088	17	high	high	JJ
cord-023168-cd7adns8	1088	18	risk	risk	NN
cord-023168-cd7adns8	1088	19	of	of	IN
cord-023168-cd7adns8	1088	20	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	1088	21	infections	infection	NNS
cord-023168-cd7adns8	1088	22	such	such	JJ
cord-023168-cd7adns8	1088	23	as	as	IN
cord-023168-cd7adns8	1088	24	pneumocystis	pneumocystis	NN
cord-023168-cd7adns8	1088	25	,	,	,
cord-023168-cd7adns8	1088	26	herpes	herpes	NNP
cord-023168-cd7adns8	1088	27	simplex	simplex	NN
cord-023168-cd7adns8	1088	28	and	and	CC
cord-023168-cd7adns8	1088	29	zoster	zoster	NN
cord-023168-cd7adns8	1088	30	and	and	CC
cord-023168-cd7adns8	1088	31	candida	candida	NN
cord-023168-cd7adns8	1088	32	.	.	.
cord-023168-cd7adns8	1089	1	Consolidation	consolidation	NN
cord-023168-cd7adns8	1089	2	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1089	3	and	and	CC
cord-023168-cd7adns8	1089	4	stem	stem	NN
cord-023168-cd7adns8	1089	5	cell	cell	NN
cord-023168-cd7adns8	1089	6	transplant	transplant	NN
cord-023168-cd7adns8	1089	7	have	have	VBP
cord-023168-cd7adns8	1089	8	been	be	VBN
cord-023168-cd7adns8	1089	9	used	use	VBN
cord-023168-cd7adns8	1089	10	successfully	successfully	RB
cord-023168-cd7adns8	1089	11	in	in	IN
cord-023168-cd7adns8	1089	12	relapsed	relapse	VBN
cord-023168-cd7adns8	1089	13	HIVrelated	hivrelate	VBN
cord-023168-cd7adns8	1089	14	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1089	15	.	.	.
cord-023168-cd7adns8	1090	1	Haemostasis	haemostasis	NN
cord-023168-cd7adns8	1090	2	is	be	VBZ
cord-023168-cd7adns8	1090	3	maintained	maintain	VBN
cord-023168-cd7adns8	1090	4	by	by	IN
cord-023168-cd7adns8	1090	5	interactions	interaction	NNS
cord-023168-cd7adns8	1090	6	between	between	IN
cord-023168-cd7adns8	1090	7	vessel	vessel	NN
cord-023168-cd7adns8	1090	8	walls	wall	NNS
cord-023168-cd7adns8	1090	9	,	,	,
cord-023168-cd7adns8	1090	10	platelets	platelet	NNS
cord-023168-cd7adns8	1090	11	and	and	CC
cord-023168-cd7adns8	1090	12	a	a	DT
cord-023168-cd7adns8	1090	13	balance	balance	NN
cord-023168-cd7adns8	1090	14	between	between	IN
cord-023168-cd7adns8	1090	15	pro	pro	JJ
cord-023168-cd7adns8	1090	16	-	-	JJ
cord-023168-cd7adns8	1090	17	and	and	CC
cord-023168-cd7adns8	1090	18	anticoagulant	anticoagulant	JJ
cord-023168-cd7adns8	1090	19	factors	factor	NNS
cord-023168-cd7adns8	1090	20	.	.	.
cord-023168-cd7adns8	1091	1	Although	although	IN
cord-023168-cd7adns8	1091	2	the	the	DT
cord-023168-cd7adns8	1091	3	process	process	NN
cord-023168-cd7adns8	1091	4	of	of	IN
cord-023168-cd7adns8	1091	5	haemostasis	haemostasis	NN
cord-023168-cd7adns8	1091	6	is	be	VBZ
cord-023168-cd7adns8	1091	7	usually	usually	RB
cord-023168-cd7adns8	1091	8	considered	consider	VBN
cord-023168-cd7adns8	1091	9	to	to	TO
cord-023168-cd7adns8	1091	10	occur	occur	VB
cord-023168-cd7adns8	1091	11	in	in	IN
cord-023168-cd7adns8	1091	12	a	a	DT
cord-023168-cd7adns8	1091	13	stepwise	stepwise	JJ
cord-023168-cd7adns8	1091	14	fashion	fashion	NN
cord-023168-cd7adns8	1091	15	,	,	,
cord-023168-cd7adns8	1091	16	in	in	IN
cord-023168-cd7adns8	1091	17	vivo	vivo	NNP
cord-023168-cd7adns8	1091	18	the	the	DT
cord-023168-cd7adns8	1091	19	steps	step	NNS
cord-023168-cd7adns8	1091	20	happen	happen	VBP
cord-023168-cd7adns8	1091	21	virtually	virtually	RB
cord-023168-cd7adns8	1091	22	simultaneously	simultaneously	RB
cord-023168-cd7adns8	1091	23	.	.	.
cord-023168-cd7adns8	1092	1	Activation	activation	NN
cord-023168-cd7adns8	1092	2	of	of	IN
cord-023168-cd7adns8	1092	3	the	the	DT
cord-023168-cd7adns8	1092	4	lining	lining	NN
cord-023168-cd7adns8	1092	5	of	of	IN
cord-023168-cd7adns8	1092	6	the	the	DT
cord-023168-cd7adns8	1092	7	endothelium	endothelium	NN
cord-023168-cd7adns8	1092	8	by	by	IN
cord-023168-cd7adns8	1092	9	trauma	trauma	NN
cord-023168-cd7adns8	1092	10	,	,	,
cord-023168-cd7adns8	1092	11	cancer	cancer	NN
cord-023168-cd7adns8	1092	12	cells	cell	NNS
cord-023168-cd7adns8	1092	13	or	or	CC
cord-023168-cd7adns8	1092	14	cytokines	cytokine	NNS
cord-023168-cd7adns8	1092	15	triggers	trigger	VBZ
cord-023168-cd7adns8	1092	16	vasoconstriction	vasoconstriction	NN
cord-023168-cd7adns8	1092	17	,	,	,
cord-023168-cd7adns8	1092	18	The	the	DT
cord-023168-cd7adns8	1092	19	tests	test	NNS
cord-023168-cd7adns8	1092	20	for	for	IN
cord-023168-cd7adns8	1092	21	each	each	DT
cord-023168-cd7adns8	1092	22	pathway	pathway	NN
cord-023168-cd7adns8	1092	23	is	be	VBZ
cord-023168-cd7adns8	1092	24	given	give	VBN
cord-023168-cd7adns8	1092	25	with	with	IN
cord-023168-cd7adns8	1092	26	arrows	arrow	NNS
cord-023168-cd7adns8	1092	27	corresponding	correspond	VBG
cord-023168-cd7adns8	1092	28	to	to	IN
cord-023168-cd7adns8	1092	29	each	each	DT
cord-023168-cd7adns8	1092	30	box	box	NN
cord-023168-cd7adns8	1092	31	complications	complication	NNS
cord-023168-cd7adns8	1092	32	,	,	,
cord-023168-cd7adns8	1092	33	malignancies	malignancy	NNS
cord-023168-cd7adns8	1092	34	and	and	CC
cord-023168-cd7adns8	1092	35	infections	infection	NNS
cord-023168-cd7adns8	1092	36	and	and	CC
cord-023168-cd7adns8	1092	37	is	be	VBZ
cord-023168-cd7adns8	1092	38	a	a	DT
cord-023168-cd7adns8	1092	39	serious	serious	JJ
cord-023168-cd7adns8	1092	40	condition	condition	NN
cord-023168-cd7adns8	1092	41	with	with	IN
cord-023168-cd7adns8	1092	42	a	a	DT
cord-023168-cd7adns8	1092	43	high	high	JJ
cord-023168-cd7adns8	1092	44	mortality	mortality	NN
cord-023168-cd7adns8	1092	45	.	.	.
cord-023168-cd7adns8	1093	1	Patients	patient	NNS
cord-023168-cd7adns8	1093	2	present	present	JJ
cord-023168-cd7adns8	1093	3	with	with	IN
cord-023168-cd7adns8	1093	4	spontaneous	spontaneous	JJ
cord-023168-cd7adns8	1093	5	bruising	bruising	NN
cord-023168-cd7adns8	1093	6	or	or	CC
cord-023168-cd7adns8	1093	7	excessive	excessive	JJ
cord-023168-cd7adns8	1093	8	bleeding	bleeding	NN
cord-023168-cd7adns8	1093	9	from	from	IN
cord-023168-cd7adns8	1093	10	minor	minor	JJ
cord-023168-cd7adns8	1093	11	wounds	wound	NNS
cord-023168-cd7adns8	1093	12	such	such	JJ
cord-023168-cd7adns8	1093	13	as	as	IN
cord-023168-cd7adns8	1093	14	venepuncture	venepuncture	NN
cord-023168-cd7adns8	1093	15	sites	site	NNS
cord-023168-cd7adns8	1093	16	,	,	,
cord-023168-cd7adns8	1093	17	and	and	CC
cord-023168-cd7adns8	1093	18	they	-PRON-	PRP
cord-023168-cd7adns8	1093	19	may	may	MD
cord-023168-cd7adns8	1093	20	also	also	RB
cord-023168-cd7adns8	1093	21	have	have	VB
cord-023168-cd7adns8	1093	22	signs	sign	NNS
cord-023168-cd7adns8	1093	23	of	of	IN
cord-023168-cd7adns8	1093	24	complications	complication	NNS
cord-023168-cd7adns8	1093	25	such	such	JJ
cord-023168-cd7adns8	1093	26	as	as	IN
cord-023168-cd7adns8	1093	27	renal	renal	JJ
cord-023168-cd7adns8	1093	28	failure	failure	NN
cord-023168-cd7adns8	1093	29	,	,	,
cord-023168-cd7adns8	1093	30	acute	acute	JJ
cord-023168-cd7adns8	1093	31	respiratory	respiratory	JJ
cord-023168-cd7adns8	1093	32	distress	distress	NN
cord-023168-cd7adns8	1093	33	syndrome	syndrome	NN
cord-023168-cd7adns8	1093	34	and	and	CC
cord-023168-cd7adns8	1093	35	microangiopathic	microangiopathic	JJ
cord-023168-cd7adns8	1093	36	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1093	37	anaemia	anaemia	NN
cord-023168-cd7adns8	1093	38	.	.	.
cord-023168-cd7adns8	1094	1	DIC	DIC	NNP
cord-023168-cd7adns8	1094	2	is	be	VBZ
cord-023168-cd7adns8	1094	3	associated	associate	VBN
cord-023168-cd7adns8	1094	4	with	with	IN
cord-023168-cd7adns8	1094	5	a	a	DT
cord-023168-cd7adns8	1094	6	combination	combination	NN
cord-023168-cd7adns8	1094	7	of	of	IN
cord-023168-cd7adns8	1094	8	depleted	depleted	JJ
cord-023168-cd7adns8	1094	9	clotting	clotting	NN
cord-023168-cd7adns8	1094	10	factors	factor	NNS
cord-023168-cd7adns8	1094	11	(	(	-LRB-
cord-023168-cd7adns8	1094	12	i.e.	i.e.	FW
cord-023168-cd7adns8	1094	13	prolonged	prolong	VBN
cord-023168-cd7adns8	1094	14	PT	PT	NNP
cord-023168-cd7adns8	1094	15	and	and	CC
cord-023168-cd7adns8	1094	16	APTT	APTT	NNP
cord-023168-cd7adns8	1094	17	)	)	-RRB-
cord-023168-cd7adns8	1094	18	,	,	,
cord-023168-cd7adns8	1094	19	a	a	DT
cord-023168-cd7adns8	1094	20	falling	fall	VBG
cord-023168-cd7adns8	1094	21	platelet	platelet	NN
cord-023168-cd7adns8	1094	22	count	count	NN
cord-023168-cd7adns8	1094	23	,	,	,
cord-023168-cd7adns8	1094	24	red	red	JJ
cord-023168-cd7adns8	1094	25	cell	cell	NN
cord-023168-cd7adns8	1094	26	fragments	fragment	NNS
cord-023168-cd7adns8	1094	27	on	on	IN
cord-023168-cd7adns8	1094	28	the	the	DT
cord-023168-cd7adns8	1094	29	blood	blood	NN
cord-023168-cd7adns8	1094	30	film	film	NN
cord-023168-cd7adns8	1094	31	,	,	,
cord-023168-cd7adns8	1094	32	raised	raise	VBD
cord-023168-cd7adns8	1094	33	D	d	NN
cord-023168-cd7adns8	1094	34	-	-	HYPH
cord-023168-cd7adns8	1094	35	dimers	dimer	NNS
cord-023168-cd7adns8	1094	36	or	or	CC
cord-023168-cd7adns8	1094	37	fibrin	fibrin	NN
cord-023168-cd7adns8	1094	38	degradation	degradation	NN
cord-023168-cd7adns8	1094	39	products	product	NNS
cord-023168-cd7adns8	1094	40	,	,	,
cord-023168-cd7adns8	1094	41	and	and	CC
cord-023168-cd7adns8	1094	42	reduced	reduce	VBN
cord-023168-cd7adns8	1094	43	fibrinogen	fibrinogen	NN
cord-023168-cd7adns8	1094	44	levels	level	NNS
cord-023168-cd7adns8	1094	45	.	.	.
cord-023168-cd7adns8	1095	1	Management	management	NN
cord-023168-cd7adns8	1095	2	of	of	IN
cord-023168-cd7adns8	1095	3	disseminated	disseminate	VBN
cord-023168-cd7adns8	1095	4	intravascular	intravascular	JJ
cord-023168-cd7adns8	1095	5	coagulation	coagulation	NN
cord-023168-cd7adns8	1095	6	includes	include	VBZ
cord-023168-cd7adns8	1095	7	treating	treat	VBG
cord-023168-cd7adns8	1095	8	or	or	CC
cord-023168-cd7adns8	1095	9	removing	remove	VBG
cord-023168-cd7adns8	1095	10	the	the	DT
cord-023168-cd7adns8	1095	11	underlying	underlie	VBG
cord-023168-cd7adns8	1095	12	cause	cause	NN
cord-023168-cd7adns8	1095	13	,	,	,
cord-023168-cd7adns8	1095	14	and	and	CC
cord-023168-cd7adns8	1095	15	correcting	correct	VBG
cord-023168-cd7adns8	1095	16	the	the	DT
cord-023168-cd7adns8	1095	17	haemostatic	haemostatic	JJ
cord-023168-cd7adns8	1095	18	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1095	19	with	with	IN
cord-023168-cd7adns8	1095	20	combinations	combination	NNS
cord-023168-cd7adns8	1095	21	of	of	IN
cord-023168-cd7adns8	1095	22	platelets	platelet	NNS
cord-023168-cd7adns8	1095	23	,	,	,
cord-023168-cd7adns8	1095	24	cryoprecipitate	cryoprecipitate	JJ
cord-023168-cd7adns8	1095	25	and	and	CC
cord-023168-cd7adns8	1095	26	fresh	fresh	JJ
cord-023168-cd7adns8	1095	27	frozen	frozen	JJ
cord-023168-cd7adns8	1095	28	plasma	plasma	NN
cord-023168-cd7adns8	1095	29	.	.	.
cord-023168-cd7adns8	1096	1	Although	although	IN
cord-023168-cd7adns8	1096	2	bleeding	bleed	VBG
cord-023168-cd7adns8	1096	3	due	due	IN
cord-023168-cd7adns8	1096	4	to	to	IN
cord-023168-cd7adns8	1096	5	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1096	6	is	be	VBZ
cord-023168-cd7adns8	1096	7	unusual	unusual	JJ
cord-023168-cd7adns8	1096	8	unless	unless	IN
cord-023168-cd7adns8	1096	9	the	the	DT
cord-023168-cd7adns8	1096	10	platelet	platelet	NN
cord-023168-cd7adns8	1096	11	counts	count	VBZ
cord-023168-cd7adns8	1096	12	falls	fall	VBZ
cord-023168-cd7adns8	1096	13	below	below	IN
cord-023168-cd7adns8	1096	14	10	10	CD
cord-023168-cd7adns8	1096	15	-	-	SYM
cord-023168-cd7adns8	1096	16	20	20	CD
cord-023168-cd7adns8	1096	17	×	×	NN
cord-023168-cd7adns8	1096	18	10	10	CD
cord-023168-cd7adns8	1096	19	9	9	CD
cord-023168-cd7adns8	1096	20	/L	/l	CD
cord-023168-cd7adns8	1096	21	,	,	,
cord-023168-cd7adns8	1096	22	bleeding	bleeding	NN
cord-023168-cd7adns8	1096	23	may	may	MD
cord-023168-cd7adns8	1096	24	occur	occur	VB
cord-023168-cd7adns8	1096	25	with	with	IN
cord-023168-cd7adns8	1096	26	a	a	DT
cord-023168-cd7adns8	1096	27	normal	normal	JJ
cord-023168-cd7adns8	1096	28	platelet	platelet	NN
cord-023168-cd7adns8	1096	29	count	count	NN
cord-023168-cd7adns8	1096	30	and	and	CC
cord-023168-cd7adns8	1096	31	normal	normal	JJ
cord-023168-cd7adns8	1096	32	clotting	clotting	NN
cord-023168-cd7adns8	1096	33	screening	screening	NN
cord-023168-cd7adns8	1096	34	tests	test	NNS
cord-023168-cd7adns8	1096	35	(	(	-LRB-
cord-023168-cd7adns8	1096	36	i.e.	i.e.	FW
cord-023168-cd7adns8	1096	37	PT	pt	NN
cord-023168-cd7adns8	1096	38	and	and	CC
cord-023168-cd7adns8	1096	39	aPTT	aptt	LS
cord-023168-cd7adns8	1096	40	)	)	-RRB-
cord-023168-cd7adns8	1096	41	if	if	IN
cord-023168-cd7adns8	1096	42	platelet	platelet	NN
cord-023168-cd7adns8	1096	43	functions	function	NNS
cord-023168-cd7adns8	1096	44	are	be	VBP
cord-023168-cd7adns8	1096	45	impaired	impaired	JJ
cord-023168-cd7adns8	1096	46	(	(	-LRB-
cord-023168-cd7adns8	1096	47	e.g.	e.g.	JJ
cord-023168-cd7adns8	1096	48	myelodysplastic	myelodysplastic	JJ
cord-023168-cd7adns8	1096	49	syndromes	syndrome	NNS
cord-023168-cd7adns8	1096	50	)	)	-RRB-
cord-023168-cd7adns8	1096	51	.	.	.
cord-023168-cd7adns8	1097	1	Platelet	platelet	NN
cord-023168-cd7adns8	1097	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	1097	3	are	be	VBP
cord-023168-cd7adns8	1097	4	generally	generally	RB
cord-023168-cd7adns8	1097	5	not	not	RB
cord-023168-cd7adns8	1097	6	required	require	VBN
cord-023168-cd7adns8	1097	7	unless	unless	IN
cord-023168-cd7adns8	1097	8	there	there	EX
cord-023168-cd7adns8	1097	9	is	be	VBZ
cord-023168-cd7adns8	1097	10	active	active	JJ
cord-023168-cd7adns8	1097	11	bleeding	bleeding	NN
cord-023168-cd7adns8	1097	12	or	or	CC
cord-023168-cd7adns8	1097	13	prior	prior	RB
cord-023168-cd7adns8	1097	14	to	to	IN
cord-023168-cd7adns8	1097	15	surgery	surgery	NN
cord-023168-cd7adns8	1097	16	.	.	.
cord-023168-cd7adns8	1098	1	Idiopathic	Idiopathic	NNP
cord-023168-cd7adns8	1098	2	Thrombocytopenic	Thrombocytopenic	NNP
cord-023168-cd7adns8	1098	3	Purpura	Purpura	NNP
cord-023168-cd7adns8	1098	4	.	.	.
cord-023168-cd7adns8	1099	1	Idiopathic	idiopathic	JJ
cord-023168-cd7adns8	1099	2	thrombocytopenic	thrombocytopenic	JJ
cord-023168-cd7adns8	1099	3	purpura	purpura	NN
cord-023168-cd7adns8	1099	4	is	be	VBZ
cord-023168-cd7adns8	1099	5	due	due	JJ
cord-023168-cd7adns8	1099	6	to	to	IN
cord-023168-cd7adns8	1099	7	immune	immune	JJ
cord-023168-cd7adns8	1099	8	destruction	destruction	NN
cord-023168-cd7adns8	1099	9	of	of	IN
cord-023168-cd7adns8	1099	10	platelets	platelet	NNS
cord-023168-cd7adns8	1099	11	.	.	.
cord-023168-cd7adns8	1100	1	It	-PRON-	PRP
cord-023168-cd7adns8	1100	2	is	be	VBZ
cord-023168-cd7adns8	1100	3	usually	usually	RB
cord-023168-cd7adns8	1100	4	primary	primary	JJ
cord-023168-cd7adns8	1100	5	but	but	CC
cord-023168-cd7adns8	1100	6	can	can	MD
cord-023168-cd7adns8	1100	7	be	be	VB
cord-023168-cd7adns8	1100	8	associated	associate	VBN
cord-023168-cd7adns8	1100	9	with	with	IN
cord-023168-cd7adns8	1100	10	conditions	condition	NNS
cord-023168-cd7adns8	1100	11	such	such	JJ
cord-023168-cd7adns8	1100	12	as	as	IN
cord-023168-cd7adns8	1100	13	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1100	14	and	and	CC
cord-023168-cd7adns8	1100	15	infections	infection	NNS
cord-023168-cd7adns8	1100	16	including	include	VBG
cord-023168-cd7adns8	1100	17	HIV	HIV	NNP
cord-023168-cd7adns8	1100	18	.	.	.
cord-023168-cd7adns8	1101	1	It	-PRON-	PRP
cord-023168-cd7adns8	1101	2	may	may	MD
cord-023168-cd7adns8	1101	3	present	present	VB
cord-023168-cd7adns8	1101	4	incidentally	incidentally	RB
cord-023168-cd7adns8	1101	5	or	or	CC
cord-023168-cd7adns8	1101	6	with	with	IN
cord-023168-cd7adns8	1101	7	petechiae	petechia	NNS
cord-023168-cd7adns8	1101	8	,	,	,
cord-023168-cd7adns8	1101	9	bruising	bruise	VBG
cord-023168-cd7adns8	1101	10	or	or	CC
cord-023168-cd7adns8	1101	11	bleeding	bleed	VBG
cord-023168-cd7adns8	1101	12	from	from	IN
cord-023168-cd7adns8	1101	13	the	the	DT
cord-023168-cd7adns8	1101	14	nose	nose	NN
cord-023168-cd7adns8	1101	15	or	or	CC
cord-023168-cd7adns8	1101	16	gums	gum	NNS
cord-023168-cd7adns8	1101	17	,	,	,
cord-023168-cd7adns8	1101	18	especially	especially	RB
cord-023168-cd7adns8	1101	19	if	if	IN
cord-023168-cd7adns8	1101	20	the	the	DT
cord-023168-cd7adns8	1101	21	platelet	platelet	NN
cord-023168-cd7adns8	1101	22	count	count	NN
cord-023168-cd7adns8	1101	23	is	be	VBZ
cord-023168-cd7adns8	1101	24	less	less	JJR
cord-023168-cd7adns8	1101	25	than	than	IN
cord-023168-cd7adns8	1101	26	20	20	CD
cord-023168-cd7adns8	1101	27	×	×	NN
cord-023168-cd7adns8	1101	28	fibrinogen	fibrinogen	NN
cord-023168-cd7adns8	1101	29	levels	level	NNS
cord-023168-cd7adns8	1101	30	,	,	,
cord-023168-cd7adns8	1101	31	which	which	WDT
cord-023168-cd7adns8	1101	32	may	may	MD
cord-023168-cd7adns8	1101	33	be	be	VB
cord-023168-cd7adns8	1101	34	helpful	helpful	JJ
cord-023168-cd7adns8	1101	35	in	in	IN
cord-023168-cd7adns8	1101	36	cases	case	NNS
cord-023168-cd7adns8	1101	37	of	of	IN
cord-023168-cd7adns8	1101	38	excessive	excessive	JJ
cord-023168-cd7adns8	1101	39	fibrinolysis	fibrinolysis	NN
cord-023168-cd7adns8	1101	40	(	(	-LRB-
cord-023168-cd7adns8	1101	41	Table	table	NN
cord-023168-cd7adns8	1101	42	65	65	CD
cord-023168-cd7adns8	1101	43	.	.	.
cord-023168-cd7adns8	1101	44	10	10	CD
cord-023168-cd7adns8	1101	45	)	)	-RRB-
cord-023168-cd7adns8	1101	46	.	.	.
cord-023168-cd7adns8	1102	1	A	a	DT
cord-023168-cd7adns8	1102	2	difficult	difficult	JJ
cord-023168-cd7adns8	1102	3	venepuncture	venepuncture	NN
cord-023168-cd7adns8	1102	4	can	can	MD
cord-023168-cd7adns8	1102	5	cause	cause	VB
cord-023168-cd7adns8	1102	6	in	in	IN
cord-023168-cd7adns8	1102	7	vitro	vitro	FW
cord-023168-cd7adns8	1102	8	activation	activation	NN
cord-023168-cd7adns8	1102	9	of	of	IN
cord-023168-cd7adns8	1102	10	the	the	DT
cord-023168-cd7adns8	1102	11	clotting	clotting	NN
cord-023168-cd7adns8	1102	12	system	system	NN
cord-023168-cd7adns8	1102	13	resulting	result	VBG
cord-023168-cd7adns8	1102	14	in	in	IN
cord-023168-cd7adns8	1102	15	a	a	DT
cord-023168-cd7adns8	1102	16	shortened	shorten	VBN
cord-023168-cd7adns8	1102	17	PT	pt	NN
cord-023168-cd7adns8	1102	18	or	or	CC
cord-023168-cd7adns8	1102	19	aPTT	aptt	NN
cord-023168-cd7adns8	1102	20	.	.	.
cord-023168-cd7adns8	1103	1	Similar	similar	JJ
cord-023168-cd7adns8	1103	2	findings	finding	NNS
cord-023168-cd7adns8	1103	3	may	may	MD
cord-023168-cd7adns8	1103	4	occur	occur	VB
cord-023168-cd7adns8	1103	5	in	in	IN
cord-023168-cd7adns8	1103	6	chronic	chronic	JJ
cord-023168-cd7adns8	1103	7	DIC	DIC	NNP
cord-023168-cd7adns8	1103	8	due	due	JJ
cord-023168-cd7adns8	1103	9	to	to	IN
cord-023168-cd7adns8	1103	10	in	in	IN
cord-023168-cd7adns8	1103	11	vivo	vivo	NN
cord-023168-cd7adns8	1103	12	activation	activation	NN
cord-023168-cd7adns8	1103	13	.	.	.
cord-023168-cd7adns8	1104	1	The	the	DT
cord-023168-cd7adns8	1104	2	PT	PT	NNP
cord-023168-cd7adns8	1104	3	and	and	CC
cord-023168-cd7adns8	1104	4	aPTT	aPTT	NNS
cord-023168-cd7adns8	1104	5	are	be	VBP
cord-023168-cd7adns8	1104	6	not	not	RB
cord-023168-cd7adns8	1104	7	necessarily	necessarily	RB
cord-023168-cd7adns8	1104	8	good	good	JJ
cord-023168-cd7adns8	1104	9	predictors	predictor	NNS
cord-023168-cd7adns8	1104	10	of	of	IN
cord-023168-cd7adns8	1104	11	the	the	DT
cord-023168-cd7adns8	1104	12	bleeding	bleed	VBG
cord-023168-cd7adns8	1104	13	risk	risk	NN
cord-023168-cd7adns8	1104	14	because	because	IN
cord-023168-cd7adns8	1104	15	some	some	DT
cord-023168-cd7adns8	1104	16	clotting	clotting	NN
cord-023168-cd7adns8	1104	17	disorders	disorder	NNS
cord-023168-cd7adns8	1104	18	associated	associate	VBN
cord-023168-cd7adns8	1104	19	with	with	IN
cord-023168-cd7adns8	1104	20	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1104	21	(	(	-LRB-
cord-023168-cd7adns8	1104	22	e.g.	e.g.	IN
cord-023168-cd7adns8	1104	23	anti	anti	JJ
cord-023168-cd7adns8	1104	24	-	-	JJ
cord-023168-cd7adns8	1104	25	phospholipid	phospholipid	JJ
cord-023168-cd7adns8	1104	26	antibodies	antibody	NNS
cord-023168-cd7adns8	1104	27	)	)	-RRB-
cord-023168-cd7adns8	1104	28	can	can	MD
cord-023168-cd7adns8	1104	29	prolong	prolong	VB
cord-023168-cd7adns8	1104	30	the	the	DT
cord-023168-cd7adns8	1104	31	aPTT	aptt	NN
cord-023168-cd7adns8	1104	32	.	.	.
cord-023168-cd7adns8	1105	1	A	a	DT
cord-023168-cd7adns8	1105	2	shortened	shorten	VBN
cord-023168-cd7adns8	1105	3	aPTT	aptt	NN
cord-023168-cd7adns8	1105	4	can	can	MD
cord-023168-cd7adns8	1105	5	be	be	VB
cord-023168-cd7adns8	1105	6	associated	associate	VBN
cord-023168-cd7adns8	1105	7	with	with	IN
cord-023168-cd7adns8	1105	8	marked	marked	JJ
cord-023168-cd7adns8	1105	9	elevation	elevation	NN
cord-023168-cd7adns8	1105	10	of	of	IN
cord-023168-cd7adns8	1105	11	factor	factor	NN
cord-023168-cd7adns8	1105	12	VIII	VIII	NNP
cord-023168-cd7adns8	1105	13	levels	level	NNS
cord-023168-cd7adns8	1105	14	(	(	-LRB-
cord-023168-cd7adns8	1105	15	e.g.	e.g.	RB
cord-023168-cd7adns8	1105	16	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1105	17	)	)	-RRB-
cord-023168-cd7adns8	1105	18	and	and	CC
cord-023168-cd7adns8	1105	19	may	may	MD
cord-023168-cd7adns8	1105	20	be	be	VB
cord-023168-cd7adns8	1105	21	a	a	DT
cord-023168-cd7adns8	1105	22	predictor	predictor	NN
cord-023168-cd7adns8	1105	23	of	of	IN
cord-023168-cd7adns8	1105	24	deep	deep	JJ
cord-023168-cd7adns8	1105	25	vein	vein	NN
cord-023168-cd7adns8	1105	26	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1105	27	.	.	.
cord-023168-cd7adns8	1106	1	A	a	DT
cord-023168-cd7adns8	1106	2	prolonged	prolonged	JJ
cord-023168-cd7adns8	1106	3	thrombin	thrombin	NN
cord-023168-cd7adns8	1106	4	time	time	NN
cord-023168-cd7adns8	1106	5	is	be	VBZ
cord-023168-cd7adns8	1106	6	caused	cause	VBN
cord-023168-cd7adns8	1106	7	by	by	IN
cord-023168-cd7adns8	1106	8	quantitative	quantitative	JJ
cord-023168-cd7adns8	1106	9	or	or	CC
cord-023168-cd7adns8	1106	10	qualitative	qualitative	JJ
cord-023168-cd7adns8	1106	11	fibrinogen	fibrinogen	NN
cord-023168-cd7adns8	1106	12	deficiency	deficiency	NN
cord-023168-cd7adns8	1106	13	,	,	,
cord-023168-cd7adns8	1106	14	heparin	heparin	NN
cord-023168-cd7adns8	1106	15	and	and	CC
cord-023168-cd7adns8	1106	16	fibrin	fibrin	NN
cord-023168-cd7adns8	1106	17	degradation	degradation	NN
cord-023168-cd7adns8	1106	18	products	product	NNS
cord-023168-cd7adns8	1106	19	.	.	.
cord-023168-cd7adns8	1107	1	Reptilase	Reptilase	NNP
cord-023168-cd7adns8	1107	2	time	time	NN
cord-023168-cd7adns8	1107	3	is	be	VBZ
cord-023168-cd7adns8	1107	4	helpful	helpful	JJ
cord-023168-cd7adns8	1107	5	to	to	TO
cord-023168-cd7adns8	1107	6	distinguish	distinguish	VB
cord-023168-cd7adns8	1107	7	between	between	IN
cord-023168-cd7adns8	1107	8	fibrinogen	fibrinogen	NN
cord-023168-cd7adns8	1107	9	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1107	10	(	(	-LRB-
cord-023168-cd7adns8	1107	11	prolonged	prolong	VBN
cord-023168-cd7adns8	1107	12	reptilase	reptilase	NN
cord-023168-cd7adns8	1107	13	time	time	NN
cord-023168-cd7adns8	1107	14	)	)	-RRB-
cord-023168-cd7adns8	1107	15	and	and	CC
cord-023168-cd7adns8	1107	16	heparin	heparin	NN
cord-023168-cd7adns8	1107	17	therapy	therapy	NN
cord-023168-cd7adns8	1107	18	(	(	-LRB-
cord-023168-cd7adns8	1107	19	normal	normal	JJ
cord-023168-cd7adns8	1107	20	reptilase	reptilase	NN
cord-023168-cd7adns8	1107	21	time	time	NN
cord-023168-cd7adns8	1107	22	)	)	-RRB-
cord-023168-cd7adns8	1107	23	.	.	.
cord-023168-cd7adns8	1108	1	Deficiency	deficiency	NN
cord-023168-cd7adns8	1108	2	of	of	IN
cord-023168-cd7adns8	1108	3	vitamin	vitamin	NN
cord-023168-cd7adns8	1108	4	K	k	NN
cord-023168-cd7adns8	1108	5	can	can	MD
cord-023168-cd7adns8	1108	6	be	be	VB
cord-023168-cd7adns8	1108	7	due	due	JJ
cord-023168-cd7adns8	1108	8	to	to	IN
cord-023168-cd7adns8	1108	9	poor	poor	JJ
cord-023168-cd7adns8	1108	10	diet	diet	NN
cord-023168-cd7adns8	1108	11	,	,	,
cord-023168-cd7adns8	1108	12	small	small	JJ
cord-023168-cd7adns8	1108	13	bowel	bowel	NN
cord-023168-cd7adns8	1108	14	disease	disease	NN
cord-023168-cd7adns8	1108	15	or	or	CC
cord-023168-cd7adns8	1108	16	bile	bile	NN
cord-023168-cd7adns8	1108	17	flow	flow	NN
cord-023168-cd7adns8	1108	18	obstruction	obstruction	NN
cord-023168-cd7adns8	1108	19	.	.	.
cord-023168-cd7adns8	1109	1	Clotting	clotting	NN
cord-023168-cd7adns8	1109	2	factors	factor	NNS
cord-023168-cd7adns8	1109	3	(	(	-LRB-
cord-023168-cd7adns8	1109	4	II	II	NNP
cord-023168-cd7adns8	1109	5	,	,	,
cord-023168-cd7adns8	1109	6	VII	VII	NNP
cord-023168-cd7adns8	1109	7	,	,	,
cord-023168-cd7adns8	1109	8	IX	IX	NNP
cord-023168-cd7adns8	1109	9	and	and	CC
cord-023168-cd7adns8	1109	10	X	X	NNP
cord-023168-cd7adns8	1109	11	)	)	-RRB-
cord-023168-cd7adns8	1109	12	are	be	VBP
cord-023168-cd7adns8	1109	13	dependent	dependent	JJ
cord-023168-cd7adns8	1109	14	on	on	IN
cord-023168-cd7adns8	1109	15	vitamin	vitamin	NN
cord-023168-cd7adns8	1109	16	K	K	NNP
cord-023168-cd7adns8	1109	17	which	which	WDT
cord-023168-cd7adns8	1109	18	is	be	VBZ
cord-023168-cd7adns8	1109	19	a	a	DT
cord-023168-cd7adns8	1109	20	fat	fat	NN
cord-023168-cd7adns8	1109	21	-	-	HYPH
cord-023168-cd7adns8	1109	22	soluble	soluble	JJ
cord-023168-cd7adns8	1109	23	vitamin	vitamin	NN
cord-023168-cd7adns8	1109	24	.	.	.
cord-023168-cd7adns8	1110	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	1110	2	K	K	NNP
cord-023168-cd7adns8	1110	3	deficiency	deficiency	NN
cord-023168-cd7adns8	1110	4	therefore	therefore	RB
cord-023168-cd7adns8	1110	5	causes	cause	VBZ
cord-023168-cd7adns8	1110	6	prolongation	prolongation	NN
cord-023168-cd7adns8	1110	7	of	of	IN
cord-023168-cd7adns8	1110	8	the	the	DT
cord-023168-cd7adns8	1110	9	PT	PT	NNP
cord-023168-cd7adns8	1110	10	and	and	CC
cord-023168-cd7adns8	1110	11	APTT	APTT	NNP
cord-023168-cd7adns8	1110	12	.	.	.
cord-023168-cd7adns8	1111	1	In	in	IN
cord-023168-cd7adns8	1111	2	newborn	newborn	JJ
cord-023168-cd7adns8	1111	3	infants	infant	NNS
cord-023168-cd7adns8	1111	4	,	,	,
cord-023168-cd7adns8	1111	5	vitamin	vitamin	NN
cord-023168-cd7adns8	1111	6	-	-	HYPH
cord-023168-cd7adns8	1111	7	K	k	NN
cord-023168-cd7adns8	1111	8	-	-	HYPH
cord-023168-cd7adns8	1111	9	dependent	dependent	JJ
cord-023168-cd7adns8	1111	10	clotting	clotting	NN
cord-023168-cd7adns8	1111	11	factors	factor	NNS
cord-023168-cd7adns8	1111	12	can	can	MD
cord-023168-cd7adns8	1111	13	drop	drop	VB
cord-023168-cd7adns8	1111	14	precipitously	precipitously	RB
cord-023168-cd7adns8	1111	15	within	within	IN
cord-023168-cd7adns8	1111	16	a	a	DT
cord-023168-cd7adns8	1111	17	couple	couple	NN
cord-023168-cd7adns8	1111	18	of	of	IN
cord-023168-cd7adns8	1111	19	days	day	NNS
cord-023168-cd7adns8	1111	20	of	of	IN
cord-023168-cd7adns8	1111	21	birth	birth	NN
cord-023168-cd7adns8	1111	22	.	.	.
cord-023168-cd7adns8	1112	1	This	this	DT
cord-023168-cd7adns8	1112	2	causes	cause	VBZ
cord-023168-cd7adns8	1112	3	haemorrhagic	haemorrhagic	JJ
cord-023168-cd7adns8	1112	4	disease	disease	NN
cord-023168-cd7adns8	1112	5	of	of	IN
cord-023168-cd7adns8	1112	6	the	the	DT
cord-023168-cd7adns8	1112	7	newborn	newborn	NN
cord-023168-cd7adns8	1112	8	which	which	WDT
cord-023168-cd7adns8	1112	9	particularly	particularly	RB
cord-023168-cd7adns8	1112	10	affects	affect	VBZ
cord-023168-cd7adns8	1112	11	infants	infant	NNS
cord-023168-cd7adns8	1112	12	that	that	WDT
cord-023168-cd7adns8	1112	13	are	be	VBP
cord-023168-cd7adns8	1112	14	premature	premature	JJ
cord-023168-cd7adns8	1112	15	,	,	,
cord-023168-cd7adns8	1112	16	exclusively	exclusively	RB
cord-023168-cd7adns8	1112	17	breast	breast	NN
cord-023168-cd7adns8	1112	18	fed	feed	VBN
cord-023168-cd7adns8	1112	19	or	or	CC
cord-023168-cd7adns8	1112	20	have	have	VBP
cord-023168-cd7adns8	1112	21	been	be	VBN
cord-023168-cd7adns8	1112	22	exposed	expose	VBN
cord-023168-cd7adns8	1112	23	to	to	IN
cord-023168-cd7adns8	1112	24	drugs	drug	NNS
cord-023168-cd7adns8	1112	25	for	for	IN
cord-023168-cd7adns8	1112	26	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	1112	27	,	,	,
cord-023168-cd7adns8	1112	28	convulsions	convulsion	NNS
cord-023168-cd7adns8	1112	29	or	or	CC
cord-023168-cd7adns8	1112	30	anticoagulation	anticoagulation	NN
cord-023168-cd7adns8	1112	31	in	in	IN
cord-023168-cd7adns8	1112	32	utero	utero	NNS
cord-023168-cd7adns8	1112	33	.	.	.
cord-023168-cd7adns8	1113	1	These	these	DT
cord-023168-cd7adns8	1113	2	babies	baby	NNS
cord-023168-cd7adns8	1113	3	develop	develop	VBP
cord-023168-cd7adns8	1113	4	bleeding	bleed	VBG
cord-023168-cd7adns8	1113	5	into	into	IN
cord-023168-cd7adns8	1113	6	the	the	DT
cord-023168-cd7adns8	1113	7	skin	skin	NN
cord-023168-cd7adns8	1113	8	and	and	CC
cord-023168-cd7adns8	1113	9	gut	gut	NN
cord-023168-cd7adns8	1113	10	,	,	,
cord-023168-cd7adns8	1113	11	or	or	CC
cord-023168-cd7adns8	1113	12	bleeding	bleed	VBG
cord-023168-cd7adns8	1113	13	from	from	IN
cord-023168-cd7adns8	1113	14	the	the	DT
cord-023168-cd7adns8	1113	15	umbilical	umbilical	JJ
cord-023168-cd7adns8	1113	16	stump	stump	NN
cord-023168-cd7adns8	1113	17	or	or	CC
cord-023168-cd7adns8	1113	18	circumcision	circumcision	NN
cord-023168-cd7adns8	1113	19	.	.	.
cord-023168-cd7adns8	1114	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	1114	2	K	K	NNP
cord-023168-cd7adns8	1114	3	deficiency	deficiency	NN
cord-023168-cd7adns8	1114	4	will	will	MD
cord-023168-cd7adns8	1114	5	respond	respond	VB
cord-023168-cd7adns8	1114	6	to	to	IN
cord-023168-cd7adns8	1114	7	intravenous	intravenous	JJ
cord-023168-cd7adns8	1114	8	vitamin	vitamin	NN
cord-023168-cd7adns8	1114	9	K	K	NNP
cord-023168-cd7adns8	1114	10	(	(	-LRB-
cord-023168-cd7adns8	1114	11	10	10	CD
cord-023168-cd7adns8	1114	12	mg	mg	NNP
cord-023168-cd7adns8	1114	13	/	/	SYM
cord-023168-cd7adns8	1114	14	day	day	NN
cord-023168-cd7adns8	1114	15	for	for	IN
cord-023168-cd7adns8	1114	16	3	3	CD
cord-023168-cd7adns8	1114	17	days	day	NNS
cord-023168-cd7adns8	1114	18	orally	orally	RB
cord-023168-cd7adns8	1114	19	or	or	CC
cord-023168-cd7adns8	1114	20	by	by	IN
cord-023168-cd7adns8	1114	21	intravenous	intravenous	JJ
cord-023168-cd7adns8	1114	22	injection	injection	NN
cord-023168-cd7adns8	1114	23	)	)	-RRB-
cord-023168-cd7adns8	1114	24	and	and	CC
cord-023168-cd7adns8	1114	25	in	in	IN
cord-023168-cd7adns8	1114	26	severe	severe	JJ
cord-023168-cd7adns8	1114	27	bleeding	bleed	VBG
cord-023168-cd7adns8	1114	28	the	the	DT
cord-023168-cd7adns8	1114	29	clotting	clotting	NN
cord-023168-cd7adns8	1114	30	abnormality	abnormality	NN
cord-023168-cd7adns8	1114	31	can	can	MD
cord-023168-cd7adns8	1114	32	be	be	VB
cord-023168-cd7adns8	1114	33	treated	treat	VBN
cord-023168-cd7adns8	1114	34	with	with	IN
cord-023168-cd7adns8	1114	35	fresh	fresh	JJ
cord-023168-cd7adns8	1114	36	frozen	frozen	JJ
cord-023168-cd7adns8	1114	37	plasma	plasma	NN
cord-023168-cd7adns8	1114	38	.	.	.
cord-023168-cd7adns8	1115	1	Haemorrhagic	Haemorrhagic	NNP
cord-023168-cd7adns8	1115	2	disease	disease	NN
cord-023168-cd7adns8	1115	3	of	of	IN
cord-023168-cd7adns8	1115	4	the	the	DT
cord-023168-cd7adns8	1115	5	newborn	newborn	NN
cord-023168-cd7adns8	1115	6	can	can	MD
cord-023168-cd7adns8	1115	7	be	be	VB
cord-023168-cd7adns8	1115	8	prevented	prevent	VBN
cord-023168-cd7adns8	1115	9	with	with	IN
cord-023168-cd7adns8	1115	10	1	1	CD
cord-023168-cd7adns8	1115	11	mg	mg	NN
cord-023168-cd7adns8	1115	12	of	of	IN
cord-023168-cd7adns8	1115	13	intramuscular	intramuscular	JJ
cord-023168-cd7adns8	1115	14	vitamin	vitamin	NN
cord-023168-cd7adns8	1115	15	K	k	NN
cord-023168-cd7adns8	1115	16	given	give	VBN
cord-023168-cd7adns8	1115	17	at	at	IN
cord-023168-cd7adns8	1115	18	delivery	delivery	NN
cord-023168-cd7adns8	1115	19	.	.	.
cord-023168-cd7adns8	1116	1	Disseminated	disseminate	VBN
cord-023168-cd7adns8	1116	2	intravascular	intravascular	JJ
cord-023168-cd7adns8	1116	3	coagulation	coagulation	NN
cord-023168-cd7adns8	1116	4	(	(	-LRB-
cord-023168-cd7adns8	1116	5	DIC	DIC	NNP
cord-023168-cd7adns8	1116	6	)	)	-RRB-
cord-023168-cd7adns8	1116	7	is	be	VBZ
cord-023168-cd7adns8	1116	8	characterized	characterize	VBN
cord-023168-cd7adns8	1116	9	by	by	IN
cord-023168-cd7adns8	1116	10	activation	activation	NN
cord-023168-cd7adns8	1116	11	of	of	IN
cord-023168-cd7adns8	1116	12	haemostasis	haemostasis	NN
cord-023168-cd7adns8	1116	13	with	with	IN
cord-023168-cd7adns8	1116	14	widespread	widespread	JJ
cord-023168-cd7adns8	1116	15	fibrin	fibrin	NN
cord-023168-cd7adns8	1116	16	formation	formation	NN
cord-023168-cd7adns8	1116	17	,	,	,
cord-023168-cd7adns8	1116	18	activation	activation	NN
cord-023168-cd7adns8	1116	19	of	of	IN
cord-023168-cd7adns8	1116	20	fibrinolysis	fibrinolysis	NN
cord-023168-cd7adns8	1116	21	and	and	CC
cord-023168-cd7adns8	1116	22	consumption	consumption	NN
cord-023168-cd7adns8	1116	23	of	of	IN
cord-023168-cd7adns8	1116	24	platelets	platelet	NNS
cord-023168-cd7adns8	1116	25	and	and	CC
cord-023168-cd7adns8	1116	26	clotting	clotting	NN
cord-023168-cd7adns8	1116	27	factors	factor	NNS
cord-023168-cd7adns8	1116	28	.	.	.
cord-023168-cd7adns8	1117	1	It	-PRON-	PRP
cord-023168-cd7adns8	1117	2	may	may	MD
cord-023168-cd7adns8	1117	3	be	be	VB
cord-023168-cd7adns8	1117	4	precipitated	precipitate	VBN
cord-023168-cd7adns8	1117	5	by	by	IN
cord-023168-cd7adns8	1117	6	tissue	tissue	NN
cord-023168-cd7adns8	1117	7	injury	injury	NN
cord-023168-cd7adns8	1117	8	,	,	,
cord-023168-cd7adns8	1117	9	obstetric	obstetric	JJ
cord-023168-cd7adns8	1117	10	 	 	_SP
cord-023168-cd7adns8	1117	11	Desmopressin	Desmopressin	NNP
cord-023168-cd7adns8	1117	12	(	(	-LRB-
cord-023168-cd7adns8	1117	13	DDAVP	DDAVP	NNP
cord-023168-cd7adns8	1117	14	)	)	-RRB-
cord-023168-cd7adns8	1117	15	is	be	VBZ
cord-023168-cd7adns8	1117	16	a	a	DT
cord-023168-cd7adns8	1117	17	relatively	relatively	RB
cord-023168-cd7adns8	1117	18	inexpensive	inexpensive	JJ
cord-023168-cd7adns8	1117	19	drug	drug	NN
cord-023168-cd7adns8	1117	20	that	that	WDT
cord-023168-cd7adns8	1117	21	increases	increase	VBZ
cord-023168-cd7adns8	1117	22	FVIII	FVIII	NNP
cord-023168-cd7adns8	1117	23	levels	level	NNS
cord-023168-cd7adns8	1117	24	and	and	CC
cord-023168-cd7adns8	1117	25	vWF	vwf	IN
cord-023168-cd7adns8	1117	26	activity	activity	NN
cord-023168-cd7adns8	1117	27	within	within	IN
cord-023168-cd7adns8	1117	28	30	30	CD
cord-023168-cd7adns8	1117	29	minutes	minute	NNS
cord-023168-cd7adns8	1117	30	of	of	IN
cord-023168-cd7adns8	1117	31	administration	administration	NN
cord-023168-cd7adns8	1117	32	.	.	.
cord-023168-cd7adns8	1118	1	It	-PRON-	PRP
cord-023168-cd7adns8	1118	2	is	be	VBZ
cord-023168-cd7adns8	1118	3	useful	useful	JJ
cord-023168-cd7adns8	1118	4	in	in	IN
cord-023168-cd7adns8	1118	5	mild	mild	JJ
cord-023168-cd7adns8	1118	6	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1118	7	and	and	CC
cord-023168-cd7adns8	1118	8	mild	mild	JJ
cord-023168-cd7adns8	1118	9	von	von	NNP
cord-023168-cd7adns8	1118	10	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1118	11	's	's	POS
cord-023168-cd7adns8	1118	12	disease	disease	NN
cord-023168-cd7adns8	1118	13	.	.	.
cord-023168-cd7adns8	1119	1	299	299	CD
cord-023168-cd7adns8	1120	1	The	the	DT
cord-023168-cd7adns8	1120	2	major	major	JJ
cord-023168-cd7adns8	1120	3	side	side	NN
cord-023168-cd7adns8	1120	4	effects	effect	NNS
cord-023168-cd7adns8	1120	5	are	be	VBP
cord-023168-cd7adns8	1120	6	headaches	headache	NNS
cord-023168-cd7adns8	1120	7	and	and	CC
cord-023168-cd7adns8	1120	8	hyponatraemia	hyponatraemia	NN
cord-023168-cd7adns8	1121	1	so	so	RB
cord-023168-cd7adns8	1121	2	fluid	fluid	JJ
cord-023168-cd7adns8	1121	3	intake	intake	NN
cord-023168-cd7adns8	1121	4	should	should	MD
cord-023168-cd7adns8	1121	5	be	be	VB
cord-023168-cd7adns8	1121	6	restricted	restrict	VBN
cord-023168-cd7adns8	1121	7	to	to	IN
cord-023168-cd7adns8	1121	8	1.5	1.5	CD
cord-023168-cd7adns8	1121	9	L/	L/	NNP
cord-023168-cd7adns8	1121	10	day	day	NN
cord-023168-cd7adns8	1121	11	.	.	.
cord-023168-cd7adns8	1122	1	Tranexamic	tranexamic	JJ
cord-023168-cd7adns8	1122	2	acid	acid	NN
cord-023168-cd7adns8	1122	3	mouthwashes	mouthwash	NNS
cord-023168-cd7adns8	1122	4	may	may	MD
cord-023168-cd7adns8	1122	5	be	be	VB
cord-023168-cd7adns8	1122	6	helpful	helpful	JJ
cord-023168-cd7adns8	1122	7	for	for	IN
cord-023168-cd7adns8	1122	8	oral	oral	JJ
cord-023168-cd7adns8	1122	9	mucosal	mucosal	JJ
cord-023168-cd7adns8	1122	10	bleeding	bleeding	NN
cord-023168-cd7adns8	1122	11	.	.	.
cord-023168-cd7adns8	1123	1	Danazol	danazol	NN
cord-023168-cd7adns8	1123	2	can	can	MD
cord-023168-cd7adns8	1123	3	increase	increase	VB
cord-023168-cd7adns8	1123	4	both	both	DT
cord-023168-cd7adns8	1123	5	factor	factor	NN
cord-023168-cd7adns8	1123	6	VIII	VIII	NNP
cord-023168-cd7adns8	1123	7	and	and	CC
cord-023168-cd7adns8	1123	8	IX	IX	NNP
cord-023168-cd7adns8	1123	9	levels	level	NNS
cord-023168-cd7adns8	1123	10	within	within	IN
cord-023168-cd7adns8	1123	11	5	5	CD
cord-023168-cd7adns8	1123	12	-	-	SYM
cord-023168-cd7adns8	1123	13	7	7	CD
cord-023168-cd7adns8	1123	14	days	day	NNS
cord-023168-cd7adns8	1123	15	300	300	CD
cord-023168-cd7adns8	1123	16	and	and	CC
cord-023168-cd7adns8	1123	17	has	have	VBZ
cord-023168-cd7adns8	1123	18	therefore	therefore	RB
cord-023168-cd7adns8	1123	19	been	be	VBN
cord-023168-cd7adns8	1123	20	recommended	recommend	VBN
cord-023168-cd7adns8	1123	21	for	for	IN
cord-023168-cd7adns8	1123	22	patients	patient	NNS
cord-023168-cd7adns8	1123	23	with	with	IN
cord-023168-cd7adns8	1123	24	recurrent	recurrent	JJ
cord-023168-cd7adns8	1123	25	haemarthrosis	haemarthrosis	NN
cord-023168-cd7adns8	1123	26	or	or	CC
cord-023168-cd7adns8	1123	27	with	with	IN
cord-023168-cd7adns8	1123	28	central	central	JJ
cord-023168-cd7adns8	1123	29	nervous	nervous	JJ
cord-023168-cd7adns8	1123	30	system	system	NN
cord-023168-cd7adns8	1123	31	bleeding	bleed	VBG
cord-023168-cd7adns8	1123	32	which	which	WDT
cord-023168-cd7adns8	1123	33	both	both	DT
cord-023168-cd7adns8	1123	34	carry	carry	VBP
cord-023168-cd7adns8	1123	35	a	a	DT
cord-023168-cd7adns8	1123	36	high	high	JJ
cord-023168-cd7adns8	1123	37	risk	risk	NN
cord-023168-cd7adns8	1123	38	of	of	IN
cord-023168-cd7adns8	1123	39	recurrence	recurrence	NN
cord-023168-cd7adns8	1123	40	.	.	.
cord-023168-cd7adns8	1124	1	Most	Most	JJS
cord-023168-cd7adns8	1124	2	thromboembolic	thromboembolic	JJ
cord-023168-cd7adns8	1124	3	episodes	episode	NNS
cord-023168-cd7adns8	1124	4	are	be	VBP
cord-023168-cd7adns8	1124	5	single	single	JJ
cord-023168-cd7adns8	1124	6	events	event	NNS
cord-023168-cd7adns8	1124	7	and	and	CC
cord-023168-cd7adns8	1124	8	may	may	MD
cord-023168-cd7adns8	1124	9	be	be	VB
cord-023168-cd7adns8	1124	10	associated	associate	VBN
cord-023168-cd7adns8	1124	11	with	with	IN
cord-023168-cd7adns8	1124	12	precipitating	precipitate	VBG
cord-023168-cd7adns8	1124	13	events	event	NNS
cord-023168-cd7adns8	1124	14	or	or	CC
cord-023168-cd7adns8	1124	15	underlying	underlying	JJ
cord-023168-cd7adns8	1124	16	risk	risk	NN
cord-023168-cd7adns8	1124	17	factors	factor	NNS
cord-023168-cd7adns8	1124	18	.	.	.
cord-023168-cd7adns8	1125	1	Thrombophilia	Thrombophilia	NNP
cord-023168-cd7adns8	1125	2	is	be	VBZ
cord-023168-cd7adns8	1125	3	the	the	DT
cord-023168-cd7adns8	1125	4	clinical	clinical	JJ
cord-023168-cd7adns8	1125	5	state	state	NN
cord-023168-cd7adns8	1125	6	of	of	IN
cord-023168-cd7adns8	1125	7	hypercoagulability	hypercoagulability	NN
cord-023168-cd7adns8	1125	8	and	and	CC
cord-023168-cd7adns8	1125	9	should	should	MD
cord-023168-cd7adns8	1125	10	be	be	VB
cord-023168-cd7adns8	1125	11	suspected	suspect	VBN
cord-023168-cd7adns8	1125	12	in	in	IN
cord-023168-cd7adns8	1125	13	patients	patient	NNS
cord-023168-cd7adns8	1125	14	who	who	WP
cord-023168-cd7adns8	1125	15	have	have	VBP
cord-023168-cd7adns8	1125	16	a	a	DT
cord-023168-cd7adns8	1125	17	strong	strong	JJ
cord-023168-cd7adns8	1125	18	family	family	NN
cord-023168-cd7adns8	1125	19	history	history	NN
cord-023168-cd7adns8	1125	20	of	of	IN
cord-023168-cd7adns8	1125	21	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1125	22	,	,	,
cord-023168-cd7adns8	1125	23	or	or	CC
cord-023168-cd7adns8	1125	24	who	who	WP
cord-023168-cd7adns8	1125	25	have	have	VBP
cord-023168-cd7adns8	1125	26	recurrent	recurrent	JJ
cord-023168-cd7adns8	1125	27	or	or	CC
cord-023168-cd7adns8	1125	28	unusual	unusual	JJ
cord-023168-cd7adns8	1125	29	thromboses	thrombose	NNS
cord-023168-cd7adns8	1125	30	.	.	.
cord-023168-cd7adns8	1126	1	Increasing	increase	VBG
cord-023168-cd7adns8	1126	2	affluence	affluence	NN
cord-023168-cd7adns8	1126	3	and	and	CC
cord-023168-cd7adns8	1126	4	consequent	consequent	JJ
cord-023168-cd7adns8	1126	5	lifestyle	lifestyle	NN
cord-023168-cd7adns8	1126	6	changes	change	NNS
cord-023168-cd7adns8	1126	7	mean	mean	VBP
cord-023168-cd7adns8	1126	8	that	that	IN
cord-023168-cd7adns8	1126	9	the	the	DT
cord-023168-cd7adns8	1126	10	prevalence	prevalence	NN
cord-023168-cd7adns8	1126	11	of	of	IN
cord-023168-cd7adns8	1126	12	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1126	13	is	be	VBZ
cord-023168-cd7adns8	1126	14	rising	rise	VBG
cord-023168-cd7adns8	1126	15	in	in	IN
cord-023168-cd7adns8	1126	16	some	some	DT
cord-023168-cd7adns8	1126	17	low	low	JJ
cord-023168-cd7adns8	1126	18	-	-	HYPH
cord-023168-cd7adns8	1126	19	and	and	CC
cord-023168-cd7adns8	1126	20	middle	middle	JJ
cord-023168-cd7adns8	1126	21	-	-	HYPH
cord-023168-cd7adns8	1126	22	income	income	NN
cord-023168-cd7adns8	1126	23	countries	country	NNS
cord-023168-cd7adns8	1126	24	.	.	.
cord-023168-cd7adns8	1127	1	Risk	risk	NN
cord-023168-cd7adns8	1127	2	factors	factor	NNS
cord-023168-cd7adns8	1127	3	such	such	JJ
cord-023168-cd7adns8	1127	4	as	as	IN
cord-023168-cd7adns8	1127	5	sedentary	sedentary	JJ
cord-023168-cd7adns8	1127	6	work	work	NN
cord-023168-cd7adns8	1127	7	,	,	,
cord-023168-cd7adns8	1127	8	obesity	obesity	NN
cord-023168-cd7adns8	1127	9	,	,	,
cord-023168-cd7adns8	1127	10	excessive	excessive	JJ
cord-023168-cd7adns8	1127	11	alcohol	alcohol	NN
cord-023168-cd7adns8	1127	12	intake	intake	NN
cord-023168-cd7adns8	1127	13	,	,	,
cord-023168-cd7adns8	1127	14	smoking	smoking	NN
cord-023168-cd7adns8	1127	15	and	and	CC
cord-023168-cd7adns8	1127	16	additional	additional	JJ
cord-023168-cd7adns8	1127	17	cardiovascular	cardiovascular	JJ
cord-023168-cd7adns8	1127	18	risk	risk	NN
cord-023168-cd7adns8	1127	19	factors	factor	NNS
cord-023168-cd7adns8	1127	20	are	be	VBP
cord-023168-cd7adns8	1127	21	compounded	compound	VBN
cord-023168-cd7adns8	1127	22	by	by	IN
cord-023168-cd7adns8	1127	23	other	other	JJ
cord-023168-cd7adns8	1127	24	10	10	CD
cord-023168-cd7adns8	1127	25	9	9	CD
cord-023168-cd7adns8	1127	26	/L.	/L.	.
cord-023168-cd7adns8	1128	1	Spontaneous	spontaneous	JJ
cord-023168-cd7adns8	1128	2	recovery	recovery	NN
cord-023168-cd7adns8	1128	3	occurs	occur	VBZ
cord-023168-cd7adns8	1128	4	less	less	RBR
cord-023168-cd7adns8	1128	5	commonly	commonly	RB
cord-023168-cd7adns8	1128	6	in	in	IN
cord-023168-cd7adns8	1128	7	adults	adult	NNS
cord-023168-cd7adns8	1128	8	than	than	IN
cord-023168-cd7adns8	1128	9	in	in	IN
cord-023168-cd7adns8	1128	10	children	child	NNS
cord-023168-cd7adns8	1128	11	.	.	.
cord-023168-cd7adns8	1129	1	It	-PRON-	PRP
cord-023168-cd7adns8	1129	2	is	be	VBZ
cord-023168-cd7adns8	1129	3	important	important	JJ
cord-023168-cd7adns8	1129	4	to	to	TO
cord-023168-cd7adns8	1129	5	exclude	exclude	VB
cord-023168-cd7adns8	1129	6	other	other	JJ
cord-023168-cd7adns8	1129	7	causes	cause	NNS
cord-023168-cd7adns8	1129	8	of	of	IN
cord-023168-cd7adns8	1129	9	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1129	10	such	such	JJ
cord-023168-cd7adns8	1129	11	as	as	IN
cord-023168-cd7adns8	1129	12	drugs	drug	NNS
cord-023168-cd7adns8	1129	13	,	,	,
cord-023168-cd7adns8	1129	14	DIC	DIC	NNP
cord-023168-cd7adns8	1129	15	or	or	CC
cord-023168-cd7adns8	1129	16	sepsis	sepsis	NN
cord-023168-cd7adns8	1129	17	.	.	.
cord-023168-cd7adns8	1130	1	The	the	DT
cord-023168-cd7adns8	1130	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1130	3	can	can	MD
cord-023168-cd7adns8	1130	4	be	be	VB
cord-023168-cd7adns8	1130	5	suspected	suspect	VBN
cord-023168-cd7adns8	1130	6	from	from	IN
cord-023168-cd7adns8	1130	7	a	a	DT
cord-023168-cd7adns8	1130	8	bone	bone	NN
cord-023168-cd7adns8	1130	9	marrow	marrow	NN
cord-023168-cd7adns8	1130	10	examination	examination	NN
cord-023168-cd7adns8	1130	11	which	which	WDT
cord-023168-cd7adns8	1130	12	shows	show	VBZ
cord-023168-cd7adns8	1130	13	increased	increase	VBN
cord-023168-cd7adns8	1130	14	numbers	number	NNS
cord-023168-cd7adns8	1130	15	of	of	IN
cord-023168-cd7adns8	1130	16	platelet	platelet	NN
cord-023168-cd7adns8	1130	17	precursors	precursor	NNS
cord-023168-cd7adns8	1130	18	.	.	.
cord-023168-cd7adns8	1131	1	Treatment	treatment	NN
cord-023168-cd7adns8	1131	2	with	with	IN
cord-023168-cd7adns8	1131	3	prednisolone	prednisolone	NN
cord-023168-cd7adns8	1131	4	(	(	-LRB-
cord-023168-cd7adns8	1131	5	0.25	0.25	CD
cord-023168-cd7adns8	1131	6	-	-	SYM
cord-023168-cd7adns8	1131	7	0.5	0.5	CD
cord-023168-cd7adns8	1131	8	mg	mg	NNP
cord-023168-cd7adns8	1131	9	/	/	SYM
cord-023168-cd7adns8	1131	10	kg	kg	NNP
cord-023168-cd7adns8	1131	11	)	)	-RRB-
cord-023168-cd7adns8	1131	12	is	be	VBZ
cord-023168-cd7adns8	1131	13	usually	usually	RB
cord-023168-cd7adns8	1131	14	only	only	RB
cord-023168-cd7adns8	1131	15	necessary	necessary	JJ
cord-023168-cd7adns8	1131	16	if	if	IN
cord-023168-cd7adns8	1131	17	there	there	EX
cord-023168-cd7adns8	1131	18	is	be	VBZ
cord-023168-cd7adns8	1131	19	bleeding	bleed	VBG
cord-023168-cd7adns8	1131	20	or	or	CC
cord-023168-cd7adns8	1131	21	excessive	excessive	JJ
cord-023168-cd7adns8	1131	22	bruising	bruising	NN
cord-023168-cd7adns8	1131	23	and	and	CC
cord-023168-cd7adns8	1131	24	the	the	DT
cord-023168-cd7adns8	1131	25	dose	dose	NN
cord-023168-cd7adns8	1131	26	should	should	MD
cord-023168-cd7adns8	1131	27	be	be	VB
cord-023168-cd7adns8	1131	28	reduced	reduce	VBN
cord-023168-cd7adns8	1131	29	slowly	slowly	RB
cord-023168-cd7adns8	1131	30	once	once	IN
cord-023168-cd7adns8	1131	31	the	the	DT
cord-023168-cd7adns8	1131	32	platelet	platelet	NN
cord-023168-cd7adns8	1131	33	count	count	NN
cord-023168-cd7adns8	1131	34	improves	improve	VBZ
cord-023168-cd7adns8	1131	35	.	.	.
cord-023168-cd7adns8	1132	1	Second	second	JJ
cord-023168-cd7adns8	1132	2	-	-	HYPH
cord-023168-cd7adns8	1132	3	line	line	NN
cord-023168-cd7adns8	1132	4	treatments	treatment	NNS
cord-023168-cd7adns8	1132	5	include	include	VBP
cord-023168-cd7adns8	1132	6	immunosuppressive	immunosuppressive	JJ
cord-023168-cd7adns8	1132	7	agents	agent	NNS
cord-023168-cd7adns8	1132	8	and	and	CC
cord-023168-cd7adns8	1132	9	danazol	danazol	NN
cord-023168-cd7adns8	1132	10	.	.	.
cord-023168-cd7adns8	1133	1	Splenectomy	Splenectomy	NNP
cord-023168-cd7adns8	1133	2	may	may	MD
cord-023168-cd7adns8	1133	3	also	also	RB
cord-023168-cd7adns8	1133	4	be	be	VB
cord-023168-cd7adns8	1133	5	beneficial	beneficial	JJ
cord-023168-cd7adns8	1133	6	but	but	CC
cord-023168-cd7adns8	1133	7	carries	carry	VBZ
cord-023168-cd7adns8	1133	8	an	an	DT
cord-023168-cd7adns8	1133	9	increased	increase	VBN
cord-023168-cd7adns8	1133	10	risk	risk	NN
cord-023168-cd7adns8	1133	11	of	of	IN
cord-023168-cd7adns8	1133	12	infection	infection	NN
cord-023168-cd7adns8	1133	13	.	.	.
cord-023168-cd7adns8	1134	1	Platelet	platelet	NN
cord-023168-cd7adns8	1134	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	1134	3	or	or	CC
cord-023168-cd7adns8	1134	4	intravenous	intravenous	JJ
cord-023168-cd7adns8	1134	5	gammaglobulin	gammaglobulin	NN
cord-023168-cd7adns8	1134	6	can	can	MD
cord-023168-cd7adns8	1134	7	temporarily	temporarily	RB
cord-023168-cd7adns8	1134	8	increase	increase	VB
cord-023168-cd7adns8	1134	9	the	the	DT
cord-023168-cd7adns8	1134	10	platelet	platelet	NN
cord-023168-cd7adns8	1134	11	count	count	NN
cord-023168-cd7adns8	1134	12	in	in	IN
cord-023168-cd7adns8	1134	13	an	an	DT
cord-023168-cd7adns8	1134	14	emergency	emergency	NN
cord-023168-cd7adns8	1134	15	or	or	CC
cord-023168-cd7adns8	1134	16	prior	prior	RB
cord-023168-cd7adns8	1134	17	to	to	IN
cord-023168-cd7adns8	1134	18	surgical	surgical	JJ
cord-023168-cd7adns8	1134	19	procedures	procedure	NNS
cord-023168-cd7adns8	1134	20	.	.	.
cord-023168-cd7adns8	1135	1	Inherited	inherited	JJ
cord-023168-cd7adns8	1135	2	bleeding	bleeding	NN
cord-023168-cd7adns8	1135	3	disorders	disorder	NNS
cord-023168-cd7adns8	1135	4	can	can	MD
cord-023168-cd7adns8	1135	5	be	be	VB
cord-023168-cd7adns8	1135	6	classified	classify	VBN
cord-023168-cd7adns8	1135	7	broadly	broadly	RB
cord-023168-cd7adns8	1135	8	into	into	IN
cord-023168-cd7adns8	1135	9	coagulation	coagulation	NN
cord-023168-cd7adns8	1135	10	factor	factor	NN
cord-023168-cd7adns8	1135	11	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1135	12	(	(	-LRB-
cord-023168-cd7adns8	1135	13	e.g.	e.g.	RB
cord-023168-cd7adns8	1135	14	factor	factor	NN
cord-023168-cd7adns8	1135	15	VIII	VIII	NNP
cord-023168-cd7adns8	1135	16	and	and	CC
cord-023168-cd7adns8	1135	17	factor	factor	NN
cord-023168-cd7adns8	1135	18	IX	IX	NNP
cord-023168-cd7adns8	1135	19	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1135	20	)	)	-RRB-
cord-023168-cd7adns8	1135	21	,	,	,
cord-023168-cd7adns8	1135	22	von	von	NNP
cord-023168-cd7adns8	1135	23	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1135	24	's	's	POS
cord-023168-cd7adns8	1135	25	disease	disease	NN
cord-023168-cd7adns8	1135	26	and	and	CC
cord-023168-cd7adns8	1135	27	platelet	platelet	NN
cord-023168-cd7adns8	1135	28	disorders	disorder	NNS
cord-023168-cd7adns8	1135	29	.	.	.
cord-023168-cd7adns8	1136	1	The	the	DT
cord-023168-cd7adns8	1136	2	frequency	frequency	NN
cord-023168-cd7adns8	1136	3	of	of	IN
cord-023168-cd7adns8	1136	4	genes	gene	NNS
cord-023168-cd7adns8	1136	5	for	for	IN
cord-023168-cd7adns8	1136	6	inherited	inherit	VBN
cord-023168-cd7adns8	1136	7	bleeding	bleeding	JJ
cord-023168-cd7adns8	1136	8	disorders	disorder	NNS
cord-023168-cd7adns8	1136	9	is	be	VBZ
cord-023168-cd7adns8	1136	10	the	the	DT
cord-023168-cd7adns8	1136	11	same	same	JJ
cord-023168-cd7adns8	1136	12	throughout	throughout	IN
cord-023168-cd7adns8	1136	13	the	the	DT
cord-023168-cd7adns8	1136	14	world	world	NN
cord-023168-cd7adns8	1136	15	.	.	.
cord-023168-cd7adns8	1137	1	Haemophilia	Haemophilia	NNP
cord-023168-cd7adns8	1137	2	A	A	NNP
cord-023168-cd7adns8	1137	3	has	have	VBZ
cord-023168-cd7adns8	1137	4	a	a	DT
cord-023168-cd7adns8	1137	5	prevalence	prevalence	NN
cord-023168-cd7adns8	1137	6	of	of	IN
cord-023168-cd7adns8	1137	7	about	about	RB
cord-023168-cd7adns8	1137	8	10/10	10/10	CD
cord-023168-cd7adns8	1137	9	000	000	CD
cord-023168-cd7adns8	1137	10	,	,	,
cord-023168-cd7adns8	1137	11	von	von	NNP
cord-023168-cd7adns8	1137	12	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1137	13	's	's	POS
cord-023168-cd7adns8	1137	14	disease	disease	NN
cord-023168-cd7adns8	1137	15	of	of	IN
cord-023168-cd7adns8	1137	16	>	>	XX
cord-023168-cd7adns8	1137	17	10/10	10/10	CD
cord-023168-cd7adns8	1137	18	000	000	CD
cord-023168-cd7adns8	1137	19	and	and	CC
cord-023168-cd7adns8	1137	20	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1137	21	B	B	NNP
cord-023168-cd7adns8	1137	22	of	of	IN
cord-023168-cd7adns8	1137	23	<	<	XX
cord-023168-cd7adns8	1137	24	0.1/10	0.1/10	XX
cord-023168-cd7adns8	1137	25	000	000	CD
cord-023168-cd7adns8	1137	26	.	.	.
cord-023168-cd7adns8	1138	1	These	these	DT
cord-023168-cd7adns8	1138	2	conditions	condition	NNS
cord-023168-cd7adns8	1138	3	occur	occur	VBP
cord-023168-cd7adns8	1138	4	more	more	RBR
cord-023168-cd7adns8	1138	5	frequently	frequently	RB
cord-023168-cd7adns8	1138	6	among	among	IN
cord-023168-cd7adns8	1138	7	populations	population	NNS
cord-023168-cd7adns8	1138	8	where	where	WRB
cord-023168-cd7adns8	1138	9	consanguineous	consanguineous	JJ
cord-023168-cd7adns8	1138	10	marriage	marriage	NN
cord-023168-cd7adns8	1138	11	is	be	VBZ
cord-023168-cd7adns8	1138	12	common	common	JJ
cord-023168-cd7adns8	1138	13	and	and	CC
cord-023168-cd7adns8	1138	14	where	where	WRB
cord-023168-cd7adns8	1138	15	prenatal	prenatal	JJ
cord-023168-cd7adns8	1138	16	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	1138	17	facilities	facility	NNS
cord-023168-cd7adns8	1138	18	are	be	VBP
cord-023168-cd7adns8	1138	19	unavailable	unavailable	JJ
cord-023168-cd7adns8	1138	20	.	.	.
cord-023168-cd7adns8	1139	1	In	in	IN
cord-023168-cd7adns8	1139	2	general	general	JJ
cord-023168-cd7adns8	1139	3	,	,	,
cord-023168-cd7adns8	1139	4	individuals	individual	NNS
cord-023168-cd7adns8	1139	5	with	with	IN
cord-023168-cd7adns8	1139	6	inherited	inherit	VBN
cord-023168-cd7adns8	1139	7	coagulation	coagulation	NN
cord-023168-cd7adns8	1139	8	factor	factor	NN
cord-023168-cd7adns8	1139	9	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1139	10	present	present	JJ
cord-023168-cd7adns8	1139	11	with	with	IN
cord-023168-cd7adns8	1139	12	soft	soft	JJ
cord-023168-cd7adns8	1139	13	tissue	tissue	NN
cord-023168-cd7adns8	1139	14	bleeds	bleed	VBZ
cord-023168-cd7adns8	1139	15	such	such	JJ
cord-023168-cd7adns8	1139	16	as	as	IN
cord-023168-cd7adns8	1139	17	haemarthroses	haemarthrose	NNS
cord-023168-cd7adns8	1139	18	or	or	CC
cord-023168-cd7adns8	1139	19	intramuscular	intramuscular	JJ
cord-023168-cd7adns8	1139	20	bleeds	bleed	VBZ
cord-023168-cd7adns8	1139	21	.	.	.
cord-023168-cd7adns8	1140	1	Those	those	DT
cord-023168-cd7adns8	1140	2	with	with	IN
cord-023168-cd7adns8	1140	3	platelet	platelet	NN
cord-023168-cd7adns8	1140	4	disorders	disorder	NNS
cord-023168-cd7adns8	1140	5	or	or	CC
cord-023168-cd7adns8	1140	6	von	von	NNP
cord-023168-cd7adns8	1140	7	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1140	8	's	's	POS
cord-023168-cd7adns8	1140	9	disease	disease	NN
cord-023168-cd7adns8	1140	10	tend	tend	VBP
cord-023168-cd7adns8	1140	11	to	to	TO
cord-023168-cd7adns8	1140	12	present	present	VB
cord-023168-cd7adns8	1140	13	with	with	IN
cord-023168-cd7adns8	1140	14	mucosal	mucosal	JJ
cord-023168-cd7adns8	1140	15	bleeds	bleed	NNS
cord-023168-cd7adns8	1140	16	,	,	,
cord-023168-cd7adns8	1140	17	however	however	RB
cord-023168-cd7adns8	1140	18	severe	severe	JJ
cord-023168-cd7adns8	1140	19	(	(	-LRB-
cord-023168-cd7adns8	1140	20	type	type	NN
cord-023168-cd7adns8	1140	21	III	iii	CD
cord-023168-cd7adns8	1140	22	)	)	-RRB-
cord-023168-cd7adns8	1141	1	von	von	NNP
cord-023168-cd7adns8	1141	2	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1141	3	's	's	POS
cord-023168-cd7adns8	1141	4	disease	disease	NN
cord-023168-cd7adns8	1141	5	can	can	MD
cord-023168-cd7adns8	1141	6	present	present	VB
cord-023168-cd7adns8	1141	7	with	with	IN
cord-023168-cd7adns8	1141	8	severe	severe	JJ
cord-023168-cd7adns8	1141	9	soft	soft	JJ
cord-023168-cd7adns8	1141	10	tissue	tissue	NN
cord-023168-cd7adns8	1141	11	bleeds	bleed	VBZ
cord-023168-cd7adns8	1141	12	.	.	.
cord-023168-cd7adns8	1142	1	Many	many	JJ
cord-023168-cd7adns8	1142	2	of	of	IN
cord-023168-cd7adns8	1142	3	these	these	DT
cord-023168-cd7adns8	1142	4	conditions	condition	NNS
cord-023168-cd7adns8	1142	5	are	be	VBP
cord-023168-cd7adns8	1142	6	diagnosed	diagnose	VBN
cord-023168-cd7adns8	1142	7	following	follow	VBG
cord-023168-cd7adns8	1142	8	excessive	excessive	JJ
cord-023168-cd7adns8	1142	9	and	and	CC
cord-023168-cd7adns8	1142	10	uncontrolled	uncontrolled	JJ
cord-023168-cd7adns8	1142	11	bleeding	bleeding	NN
cord-023168-cd7adns8	1142	12	after	after	IN
cord-023168-cd7adns8	1142	13	trauma	trauma	NN
cord-023168-cd7adns8	1142	14	or	or	CC
cord-023168-cd7adns8	1142	15	surgical	surgical	JJ
cord-023168-cd7adns8	1142	16	procedures	procedure	NNS
cord-023168-cd7adns8	1142	17	.	.	.
cord-023168-cd7adns8	1143	1	Menorrhagia	Menorrhagia	NNP
cord-023168-cd7adns8	1143	2	and	and	CC
cord-023168-cd7adns8	1143	3	delayed	delay	VBN
cord-023168-cd7adns8	1143	4	severe	severe	JJ
cord-023168-cd7adns8	1143	5	postpartum	postpartum	NN
cord-023168-cd7adns8	1143	6	haemorrhage	haemorrhage	NN
cord-023168-cd7adns8	1143	7	may	may	MD
cord-023168-cd7adns8	1143	8	be	be	VB
cord-023168-cd7adns8	1143	9	presenting	present	VBG
cord-023168-cd7adns8	1143	10	features	feature	NNS
cord-023168-cd7adns8	1143	11	of	of	IN
cord-023168-cd7adns8	1143	12	bleeding	bleed	VBG
cord-023168-cd7adns8	1143	13	disorders	disorder	NNS
cord-023168-cd7adns8	1143	14	,	,	,
cord-023168-cd7adns8	1143	15	particularly	particularly	RB
cord-023168-cd7adns8	1143	16	von	von	NNP
cord-023168-cd7adns8	1143	17	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1143	18	's	's	POS
cord-023168-cd7adns8	1143	19	disease	disease	NN
cord-023168-cd7adns8	1143	20	or	or	CC
cord-023168-cd7adns8	1143	21	hypothyroidism	hypothyroidism	NN
cord-023168-cd7adns8	1143	22	,	,	,
cord-023168-cd7adns8	1143	23	which	which	WDT
cord-023168-cd7adns8	1143	24	can	can	MD
cord-023168-cd7adns8	1143	25	cause	cause	VB
cord-023168-cd7adns8	1143	26	decreased	decrease	VBN
cord-023168-cd7adns8	1143	27	synthesis	synthesis	NN
cord-023168-cd7adns8	1143	28	of	of	IN
cord-023168-cd7adns8	1143	29	von	von	NNP
cord-023168-cd7adns8	1143	30	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1143	31	factor	factor	NN
cord-023168-cd7adns8	1143	32	.	.	.
cord-023168-cd7adns8	1144	1	Some	some	DT
cord-023168-cd7adns8	1144	2	inherited	inherit	VBN
cord-023168-cd7adns8	1144	3	platelet	platelet	NN
cord-023168-cd7adns8	1144	4	function	function	NN
cord-023168-cd7adns8	1144	5	disorders	disorder	NNS
cord-023168-cd7adns8	1144	6	are	be	VBP
cord-023168-cd7adns8	1144	7	associated	associate	VBN
cord-023168-cd7adns8	1144	8	with	with	IN
cord-023168-cd7adns8	1144	9	characteristic	characteristic	JJ
cord-023168-cd7adns8	1144	10	syndromes	syndrome	NNS
cord-023168-cd7adns8	1144	11	(	(	-LRB-
cord-023168-cd7adns8	1144	12	e.g.	e.g.	RB
cord-023168-cd7adns8	1144	13	oculocutaneous	oculocutaneous	JJ
cord-023168-cd7adns8	1144	14	albinism	albinism	NN
cord-023168-cd7adns8	1144	15	or	or	CC
cord-023168-cd7adns8	1144	16	skeletal	skeletal	JJ
cord-023168-cd7adns8	1144	17	defects	defect	NNS
cord-023168-cd7adns8	1144	18	)	)	-RRB-
cord-023168-cd7adns8	1144	19	which	which	WDT
cord-023168-cd7adns8	1144	20	may	may	MD
cord-023168-cd7adns8	1144	21	provide	provide	VB
cord-023168-cd7adns8	1144	22	a	a	DT
cord-023168-cd7adns8	1144	23	clue	clue	NN
cord-023168-cd7adns8	1144	24	to	to	IN
cord-023168-cd7adns8	1144	25	the	the	DT
cord-023168-cd7adns8	1144	26	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1144	27	.	.	.
cord-023168-cd7adns8	1145	1	Early	early	JJ
cord-023168-cd7adns8	1145	2	recognition	recognition	NN
cord-023168-cd7adns8	1145	3	of	of	IN
cord-023168-cd7adns8	1145	4	symptoms	symptom	NNS
cord-023168-cd7adns8	1145	5	by	by	IN
cord-023168-cd7adns8	1145	6	clinicians	clinician	NNS
cord-023168-cd7adns8	1145	7	,	,	,
cord-023168-cd7adns8	1145	8	teachers	teacher	NNS
cord-023168-cd7adns8	1145	9	and	and	CC
cord-023168-cd7adns8	1145	10	the	the	DT
cord-023168-cd7adns8	1145	11	public	public	NN
cord-023168-cd7adns8	1145	12	is	be	VBZ
cord-023168-cd7adns8	1145	13	important	important	JJ
cord-023168-cd7adns8	1145	14	so	so	IN
cord-023168-cd7adns8	1145	15	that	that	IN
cord-023168-cd7adns8	1145	16	early	early	JJ
cord-023168-cd7adns8	1145	17	treatment	treatment	NN
cord-023168-cd7adns8	1145	18	can	can	MD
cord-023168-cd7adns8	1145	19	be	be	VB
cord-023168-cd7adns8	1145	20	established	establish	VBN
cord-023168-cd7adns8	1145	21	.	.	.
cord-023168-cd7adns8	1146	1	Patients	patient	NNS
cord-023168-cd7adns8	1146	2	with	with	IN
cord-023168-cd7adns8	1146	3	inherited	inherit	VBN
cord-023168-cd7adns8	1146	4	bleeding	bleeding	JJ
cord-023168-cd7adns8	1146	5	disorders	disorder	NNS
cord-023168-cd7adns8	1146	6	are	be	VBP
cord-023168-cd7adns8	1146	7	usually	usually	RB
cord-023168-cd7adns8	1146	8	managed	manage	VBN
cord-023168-cd7adns8	1146	9	with	with	IN
cord-023168-cd7adns8	1146	10	blood	blood	NN
cord-023168-cd7adns8	1146	11	products	product	NNS
cord-023168-cd7adns8	1146	12	(	(	-LRB-
cord-023168-cd7adns8	1146	13	Box	Box	NNP
cord-023168-cd7adns8	1146	14	65.20	65.20	CD
cord-023168-cd7adns8	1146	15	)	)	-RRB-
cord-023168-cd7adns8	1146	16	or	or	CC
cord-023168-cd7adns8	1146	17	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1146	18	designed	design	VBN
cord-023168-cd7adns8	1146	19	to	to	TO
cord-023168-cd7adns8	1146	20	reduce	reduce	VB
cord-023168-cd7adns8	1146	21	bleeding	bleed	VBG
cord-023168-cd7adns8	1146	22	and	and	CC
cord-023168-cd7adns8	1146	23	associated	associated	JJ
cord-023168-cd7adns8	1146	24	complications	complication	NNS
cord-023168-cd7adns8	1146	25	.	.	.
cord-023168-cd7adns8	1147	1	295	295	CD
cord-023168-cd7adns8	1147	2	,	,	,
cord-023168-cd7adns8	1147	3	296	296	CD
cord-023168-cd7adns8	1147	4	,	,	,
cord-023168-cd7adns8	1147	5	298	298	CD
cord-023168-cd7adns8	1147	6	,	,	,
cord-023168-cd7adns8	1147	7	299	299	CD
cord-023168-cd7adns8	1147	8	Clotting	clotting	NN
cord-023168-cd7adns8	1147	9	factor	factor	NN
cord-023168-cd7adns8	1147	10	concentrates	concentrate	NNS
cord-023168-cd7adns8	1147	11	may	may	MD
cord-023168-cd7adns8	1147	12	be	be	VB
cord-023168-cd7adns8	1147	13	imported	import	VBN
cord-023168-cd7adns8	1147	14	or	or	CC
cord-023168-cd7adns8	1147	15	produced	produce	VBN
cord-023168-cd7adns8	1147	16	locally	locally	RB
cord-023168-cd7adns8	1147	17	by	by	IN
cord-023168-cd7adns8	1147	18	fractionation	fractionation	NN
cord-023168-cd7adns8	1147	19	of	of	IN
cord-023168-cd7adns8	1147	20	plasma	plasma	NN
cord-023168-cd7adns8	1147	21	and	and	CC
cord-023168-cd7adns8	1147	22	are	be	VBP
cord-023168-cd7adns8	1147	23	included	include	VBN
cord-023168-cd7adns8	1147	24	in	in	IN
cord-023168-cd7adns8	1147	25	the	the	DT
cord-023168-cd7adns8	1147	26	WHO	WHO	NNP
cord-023168-cd7adns8	1147	27	list	list	NN
cord-023168-cd7adns8	1147	28	of	of	IN
cord-023168-cd7adns8	1147	29	essential	essential	JJ
cord-023168-cd7adns8	1147	30	medicines	medicine	NNS
cord-023168-cd7adns8	1147	31	.	.	.
cord-023168-cd7adns8	1148	1	297	297	CD
cord-023168-cd7adns8	1148	2	,	,	,
cord-023168-cd7adns8	1148	3	298	298	CD
cord-023168-cd7adns8	1148	4	One	one	CD
cord-023168-cd7adns8	1148	5	international	international	JJ
cord-023168-cd7adns8	1148	6	unit	unit	NN
cord-023168-cd7adns8	1148	7	(	(	-LRB-
cord-023168-cd7adns8	1148	8	IU	IU	NNP
cord-023168-cd7adns8	1148	9	)	)	-RRB-
cord-023168-cd7adns8	1148	10	of	of	IN
cord-023168-cd7adns8	1148	11	FVIII	FVIII	NNP
cord-023168-cd7adns8	1148	12	clotting	clotting	NN
cord-023168-cd7adns8	1148	13	factor	factor	NN
cord-023168-cd7adns8	1148	14	concentrate	concentrate	NN
cord-023168-cd7adns8	1148	15	per	per	IN
cord-023168-cd7adns8	1148	16	capita	capita	NN
cord-023168-cd7adns8	1148	17	is	be	VBZ
cord-023168-cd7adns8	1148	18	recommended	recommend	VBN
cord-023168-cd7adns8	1148	19	as	as	IN
cord-023168-cd7adns8	1148	20	the	the	DT
cord-023168-cd7adns8	1148	21	minimum	minimum	JJ
cord-023168-cd7adns8	1148	22	requirement	requirement	NN
cord-023168-cd7adns8	1148	23	for	for	IN
cord-023168-cd7adns8	1148	24	countries	country	NNS
cord-023168-cd7adns8	1148	25	wishing	wish	VBG
cord-023168-cd7adns8	1148	26	to	to	TO
cord-023168-cd7adns8	1148	27	achieve	achieve	VB
cord-023168-cd7adns8	1148	28	optimal	optimal	JJ
cord-023168-cd7adns8	1148	29	survival	survival	NN
cord-023168-cd7adns8	1148	30	for	for	IN
cord-023168-cd7adns8	1148	31	their	-PRON-	PRP$
cord-023168-cd7adns8	1148	32	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1148	33	population	population	NN
cord-023168-cd7adns8	1148	34	but	but	CC
cord-023168-cd7adns8	1148	35	only	only	RB
cord-023168-cd7adns8	1148	36	about	about	RB
cord-023168-cd7adns8	1148	37	25	25	CD
cord-023168-cd7adns8	1148	38	%	%	NN
cord-023168-cd7adns8	1148	39	of	of	IN
cord-023168-cd7adns8	1148	40	the	the	DT
cord-023168-cd7adns8	1148	41	estimated	estimate	VBN
cord-023168-cd7adns8	1148	42	400	400	CD
cord-023168-cd7adns8	1148	43	000	000	CD
cord-023168-cd7adns8	1148	44	people	people	NNS
cord-023168-cd7adns8	1148	45	in	in	IN
cord-023168-cd7adns8	1148	46	the	the	DT
cord-023168-cd7adns8	1148	47	world	world	NN
cord-023168-cd7adns8	1148	48	with	with	IN
cord-023168-cd7adns8	1148	49	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1148	50	receive	receive	VBP
cord-023168-cd7adns8	1148	51	adequate	adequate	JJ
cord-023168-cd7adns8	1148	52	treatment	treatment	NN
cord-023168-cd7adns8	1148	53	.	.	.
cord-023168-cd7adns8	1149	1	Management	management	NN
cord-023168-cd7adns8	1149	2	of	of	IN
cord-023168-cd7adns8	1149	3	patients	patient	NNS
cord-023168-cd7adns8	1149	4	with	with	IN
cord-023168-cd7adns8	1149	5	bleeding	bleed	VBG
cord-023168-cd7adns8	1149	6	disorders	disorder	NNS
cord-023168-cd7adns8	1149	7	relies	rely	VBZ
cord-023168-cd7adns8	1149	8	on	on	IN
cord-023168-cd7adns8	1149	9	a	a	DT
cord-023168-cd7adns8	1149	10	wellequipped	wellequipped	JJ
cord-023168-cd7adns8	1149	11	and	and	CC
cord-023168-cd7adns8	1149	12	quality	quality	NN
cord-023168-cd7adns8	1149	13	assessed	assess	VBN
cord-023168-cd7adns8	1149	14	laboratory	laboratory	NN
cord-023168-cd7adns8	1149	15	for	for	IN
cord-023168-cd7adns8	1149	16	accurate	accurate	JJ
cord-023168-cd7adns8	1149	17	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1149	18	and	and	CC
cord-023168-cd7adns8	1149	19	monitoring	monitoring	NN
cord-023168-cd7adns8	1149	20	of	of	IN
cord-023168-cd7adns8	1149	21	treatment	treatment	NN
cord-023168-cd7adns8	1149	22	and	and	CC
cord-023168-cd7adns8	1149	23	access	access	NN
cord-023168-cd7adns8	1149	24	to	to	IN
cord-023168-cd7adns8	1149	25	plasma	plasma	NN
cord-023168-cd7adns8	1149	26	and	and	CC
cord-023168-cd7adns8	1149	27	components	component	NNS
cord-023168-cd7adns8	1149	28	for	for	IN
cord-023168-cd7adns8	1149	29	replacement	replacement	NN
cord-023168-cd7adns8	1149	30	therapy	therapy	NN
cord-023168-cd7adns8	1149	31	.	.	.
cord-023168-cd7adns8	1150	1	Appropriate	appropriate	JJ
cord-023168-cd7adns8	1150	2	support	support	NN
cord-023168-cd7adns8	1150	3	services	service	NNS
cord-023168-cd7adns8	1150	4	such	such	JJ
cord-023168-cd7adns8	1150	5	as	as	IN
cord-023168-cd7adns8	1150	6	physiotherapy	physiotherapy	NN
cord-023168-cd7adns8	1150	7	,	,	,
cord-023168-cd7adns8	1150	8	orthopaedics	orthopaedics	NN
cord-023168-cd7adns8	1150	9	and	and	CC
cord-023168-cd7adns8	1150	10	counselling	counselling	NN
cord-023168-cd7adns8	1150	11	should	should	MD
cord-023168-cd7adns8	1150	12	also	also	RB
cord-023168-cd7adns8	1150	13	be	be	VB
cord-023168-cd7adns8	1150	14	available	available	JJ
cord-023168-cd7adns8	1150	15	.	.	.
cord-023168-cd7adns8	1151	1	In	in	IN
cord-023168-cd7adns8	1151	2	many	many	JJ
cord-023168-cd7adns8	1151	3	countries	country	NNS
cord-023168-cd7adns8	1151	4	inherited	inherit	VBD
cord-023168-cd7adns8	1151	5	bleeding	bleeding	NN
cord-023168-cd7adns8	1151	6	disorders	disorder	NNS
cord-023168-cd7adns8	1151	7	are	be	VBP
cord-023168-cd7adns8	1151	8	associated	associate	VBN
cord-023168-cd7adns8	1151	9	with	with	IN
cord-023168-cd7adns8	1151	10	stigma	stigma	NN
cord-023168-cd7adns8	1151	11	,	,	,
cord-023168-cd7adns8	1151	12	which	which	WDT
cord-023168-cd7adns8	1151	13	is	be	VBZ
cord-023168-cd7adns8	1151	14	particularly	particularly	RB
cord-023168-cd7adns8	1151	15	directed	direct	VBN
cord-023168-cd7adns8	1151	16	against	against	IN
cord-023168-cd7adns8	1151	17	the	the	DT
cord-023168-cd7adns8	1151	18	mothers	mother	NNS
cord-023168-cd7adns8	1151	19	of	of	IN
cord-023168-cd7adns8	1151	20	affected	affected	JJ
cord-023168-cd7adns8	1151	21	children	child	NNS
cord-023168-cd7adns8	1151	22	,	,	,
cord-023168-cd7adns8	1151	23	297	297	CD
cord-023168-cd7adns8	1151	24	 	 	_SP
cord-023168-cd7adns8	1151	25	Acute	acute	JJ
cord-023168-cd7adns8	1151	26	and	and	CC
cord-023168-cd7adns8	1151	27	chronic	chronic	JJ
cord-023168-cd7adns8	1151	28	leukaemias	leukaemia	NNS
cord-023168-cd7adns8	1151	29	are	be	VBP
cord-023168-cd7adns8	1151	30	usually	usually	RB
cord-023168-cd7adns8	1151	31	associated	associate	VBN
cord-023168-cd7adns8	1151	32	with	with	IN
cord-023168-cd7adns8	1151	33	a	a	DT
cord-023168-cd7adns8	1151	34	high	high	JJ
cord-023168-cd7adns8	1151	35	white	white	JJ
cord-023168-cd7adns8	1151	36	cell	cell	NN
cord-023168-cd7adns8	1151	37	count	count	NN
cord-023168-cd7adns8	1151	38	but	but	CC
cord-023168-cd7adns8	1151	39	acute	acute	JJ
cord-023168-cd7adns8	1151	40	leukaemias	leukaemias	NNP
cord-023168-cd7adns8	1151	41	can	can	MD
cord-023168-cd7adns8	1151	42	present	present	VB
cord-023168-cd7adns8	1151	43	with	with	IN
cord-023168-cd7adns8	1151	44	normal	normal	JJ
cord-023168-cd7adns8	1151	45	or	or	CC
cord-023168-cd7adns8	1151	46	even	even	RB
cord-023168-cd7adns8	1151	47	sub	sub	JJ
cord-023168-cd7adns8	1151	48	-	-	JJ
cord-023168-cd7adns8	1151	49	normal	normal	JJ
cord-023168-cd7adns8	1151	50	white	white	JJ
cord-023168-cd7adns8	1151	51	cell	cell	NN
cord-023168-cd7adns8	1151	52	counts	count	NNS
cord-023168-cd7adns8	1151	53	.	.	.
cord-023168-cd7adns8	1152	1	Morphology	morphology	NN
cord-023168-cd7adns8	1152	2	of	of	IN
cord-023168-cd7adns8	1152	3	peripheral	peripheral	JJ
cord-023168-cd7adns8	1152	4	blood	blood	NN
cord-023168-cd7adns8	1152	5	and	and	CC
cord-023168-cd7adns8	1152	6	bone	bone	NN
cord-023168-cd7adns8	1152	7	marrow	marrow	NN
cord-023168-cd7adns8	1152	8	specimens	specimen	NNS
cord-023168-cd7adns8	1152	9	is	be	VBZ
cord-023168-cd7adns8	1152	10	crucial	crucial	JJ
cord-023168-cd7adns8	1152	11	to	to	TO
cord-023168-cd7adns8	1152	12	confirm	confirm	VB
cord-023168-cd7adns8	1152	13	the	the	DT
cord-023168-cd7adns8	1152	14	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1152	15	.	.	.
cord-023168-cd7adns8	1153	1	This	this	DT
cord-023168-cd7adns8	1153	2	is	be	VBZ
cord-023168-cd7adns8	1153	3	particularly	particularly	RB
cord-023168-cd7adns8	1153	4	important	important	JJ
cord-023168-cd7adns8	1153	5	in	in	IN
cord-023168-cd7adns8	1153	6	the	the	DT
cord-023168-cd7adns8	1153	7	case	case	NN
cord-023168-cd7adns8	1153	8	of	of	IN
cord-023168-cd7adns8	1153	9	acute	acute	JJ
cord-023168-cd7adns8	1153	10	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1153	11	in	in	IN
cord-023168-cd7adns8	1153	12	children	child	NNS
cord-023168-cd7adns8	1153	13	which	which	WDT
cord-023168-cd7adns8	1153	14	may	may	MD
cord-023168-cd7adns8	1153	15	be	be	VB
cord-023168-cd7adns8	1153	16	mistaken	mistake	VBN
cord-023168-cd7adns8	1153	17	for	for	IN
cord-023168-cd7adns8	1153	18	an	an	DT
cord-023168-cd7adns8	1153	19	acute	acute	JJ
cord-023168-cd7adns8	1153	20	viral	viral	JJ
cord-023168-cd7adns8	1153	21	infection	infection	NN
cord-023168-cd7adns8	1153	22	.	.	.
cord-023168-cd7adns8	1154	1	Staining	staining	NN
cord-023168-cd7adns8	1154	2	methods	method	NNS
cord-023168-cd7adns8	1154	3	including	include	VBG
cord-023168-cd7adns8	1154	4	Sudan	Sudan	NNP
cord-023168-cd7adns8	1154	5	black	black	JJ
cord-023168-cd7adns8	1154	6	B	b	NN
cord-023168-cd7adns8	1154	7	,	,	,
cord-023168-cd7adns8	1154	8	myeloperoxidase	myeloperoxidase	NN
cord-023168-cd7adns8	1154	9	and	and	CC
cord-023168-cd7adns8	1154	10	nonspecific	nonspecific	JJ
cord-023168-cd7adns8	1154	11	esterase	esterase	NN
cord-023168-cd7adns8	1154	12	are	be	VBP
cord-023168-cd7adns8	1154	13	important	important	JJ
cord-023168-cd7adns8	1154	14	to	to	TO
cord-023168-cd7adns8	1154	15	distinguish	distinguish	VB
cord-023168-cd7adns8	1154	16	between	between	IN
cord-023168-cd7adns8	1154	17	the	the	DT
cord-023168-cd7adns8	1154	18	different	different	JJ
cord-023168-cd7adns8	1154	19	subtypes	subtype	NNS
cord-023168-cd7adns8	1154	20	of	of	IN
cord-023168-cd7adns8	1154	21	acute	acute	JJ
cord-023168-cd7adns8	1154	22	myeloid	myeloid	JJ
cord-023168-cd7adns8	1154	23	and	and	CC
cord-023168-cd7adns8	1154	24	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1154	25	leukaemias	leukaemias	NNP
cord-023168-cd7adns8	1154	26	and	and	CC
cord-023168-cd7adns8	1154	27	therefore	therefore	RB
cord-023168-cd7adns8	1154	28	to	to	TO
cord-023168-cd7adns8	1154	29	guide	guide	VB
cord-023168-cd7adns8	1154	30	treatment	treatment	NN
cord-023168-cd7adns8	1154	31	.	.	.
cord-023168-cd7adns8	1155	1	Acute	acute	JJ
cord-023168-cd7adns8	1155	2	Myeloid	Myeloid	NNP
cord-023168-cd7adns8	1155	3	Leukaemia	Leukaemia	NNP
cord-023168-cd7adns8	1155	4	(	(	-LRB-
cord-023168-cd7adns8	1155	5	AML	AML	NNP
cord-023168-cd7adns8	1155	6	)	)	-RRB-
cord-023168-cd7adns8	1155	7	.	.	.
cord-023168-cd7adns8	1156	1	Prevalence	prevalence	NN
cord-023168-cd7adns8	1156	2	of	of	IN
cord-023168-cd7adns8	1156	3	this	this	DT
cord-023168-cd7adns8	1156	4	increases	increase	NNS
cord-023168-cd7adns8	1156	5	with	with	IN
cord-023168-cd7adns8	1156	6	age	age	NN
cord-023168-cd7adns8	1156	7	and	and	CC
cord-023168-cd7adns8	1156	8	the	the	DT
cord-023168-cd7adns8	1156	9	success	success	NN
cord-023168-cd7adns8	1156	10	rate	rate	NN
cord-023168-cd7adns8	1156	11	with	with	IN
cord-023168-cd7adns8	1156	12	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1156	13	protocols	protocol	NNS
cord-023168-cd7adns8	1156	14	is	be	VBZ
cord-023168-cd7adns8	1156	15	not	not	RB
cord-023168-cd7adns8	1156	16	high	high	JJ
cord-023168-cd7adns8	1156	17	even	even	RB
cord-023168-cd7adns8	1156	18	in	in	IN
cord-023168-cd7adns8	1156	19	the	the	DT
cord-023168-cd7adns8	1156	20	most	most	RBS
cord-023168-cd7adns8	1156	21	sophisticated	sophisticated	JJ
cord-023168-cd7adns8	1156	22	centres	centre	NNS
cord-023168-cd7adns8	1156	23	.	.	.
cord-023168-cd7adns8	1157	1	Neutropenia	Neutropenia	NNP
cord-023168-cd7adns8	1157	2	and	and	CC
cord-023168-cd7adns8	1157	3	myelosuppression	myelosuppression	VB
cord-023168-cd7adns8	1157	4	requiring	require	VBG
cord-023168-cd7adns8	1157	5	intensive	intensive	JJ
cord-023168-cd7adns8	1157	6	blood	blood	NN
cord-023168-cd7adns8	1157	7	component	component	NN
cord-023168-cd7adns8	1157	8	support	support	NN
cord-023168-cd7adns8	1157	9	occur	occur	VBP
cord-023168-cd7adns8	1157	10	during	during	IN
cord-023168-cd7adns8	1157	11	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1157	12	314	314	CD
cord-023168-cd7adns8	1157	13	and	and	CC
cord-023168-cd7adns8	1157	14	bone	bone	NN
cord-023168-cd7adns8	1157	15	marrow	marrow	NN
cord-023168-cd7adns8	1157	16	transplantation	transplantation	NN
cord-023168-cd7adns8	1157	17	offers	offer	VBZ
cord-023168-cd7adns8	1157	18	the	the	DT
cord-023168-cd7adns8	1157	19	best	good	JJS
cord-023168-cd7adns8	1157	20	option	option	NN
cord-023168-cd7adns8	1157	21	for	for	IN
cord-023168-cd7adns8	1157	22	cure	cure	NN
cord-023168-cd7adns8	1157	23	for	for	IN
cord-023168-cd7adns8	1157	24	patients	patient	NNS
cord-023168-cd7adns8	1157	25	who	who	WP
cord-023168-cd7adns8	1157	26	relapse	relapse	VBP
cord-023168-cd7adns8	1157	27	.	.	.
cord-023168-cd7adns8	1158	1	Management	Management	NNP
cord-023168-cd7adns8	1158	2	of	of	IN
cord-023168-cd7adns8	1158	3	AML	AML	NNP
cord-023168-cd7adns8	1158	4	is	be	VBZ
cord-023168-cd7adns8	1158	5	therefore	therefore	RB
cord-023168-cd7adns8	1158	6	complex	complex	JJ
cord-023168-cd7adns8	1158	7	and	and	CC
cord-023168-cd7adns8	1158	8	expensive	expensive	JJ
cord-023168-cd7adns8	1158	9	.	.	.
cord-023168-cd7adns8	1159	1	Hydroxycarbamide	hydroxycarbamide	JJ
cord-023168-cd7adns8	1159	2	or	or	CC
cord-023168-cd7adns8	1159	3	subcutaneous	subcutaneous	JJ
cord-023168-cd7adns8	1159	4	cytarabine	cytarabine	NNP
cord-023168-cd7adns8	1159	5	may	may	MD
cord-023168-cd7adns8	1159	6	be	be	VB
cord-023168-cd7adns8	1159	7	used	use	VBN
cord-023168-cd7adns8	1159	8	as	as	IN
cord-023168-cd7adns8	1159	9	a	a	DT
cord-023168-cd7adns8	1159	10	palliative	palliative	JJ
cord-023168-cd7adns8	1159	11	treatment	treatment	NN
cord-023168-cd7adns8	1159	12	.	.	.
cord-023168-cd7adns8	1160	1	Acute	acute	JJ
cord-023168-cd7adns8	1160	2	Promyelocytic	Promyelocytic	NNP
cord-023168-cd7adns8	1160	3	Leukaemia	Leukaemia	NNP
cord-023168-cd7adns8	1160	4	(	(	-LRB-
cord-023168-cd7adns8	1160	5	AML	AML	NNP
cord-023168-cd7adns8	1160	6	Subtype	Subtype	NNP
cord-023168-cd7adns8	1160	7	M3	M3	NNP
cord-023168-cd7adns8	1160	8	)	)	-RRB-
cord-023168-cd7adns8	1160	9	.	.	.
cord-023168-cd7adns8	1161	1	This	this	DT
cord-023168-cd7adns8	1161	2	must	must	MD
cord-023168-cd7adns8	1161	3	be	be	VB
cord-023168-cd7adns8	1161	4	distinguished	distinguish	VBN
cord-023168-cd7adns8	1161	5	from	from	IN
cord-023168-cd7adns8	1161	6	other	other	JJ
cord-023168-cd7adns8	1161	7	types	type	NNS
cord-023168-cd7adns8	1161	8	of	of	IN
cord-023168-cd7adns8	1161	9	acute	acute	JJ
cord-023168-cd7adns8	1161	10	myeloid	myeloid	NN
cord-023168-cd7adns8	1161	11	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1161	12	because	because	IN
cord-023168-cd7adns8	1161	13	it	-PRON-	PRP
cord-023168-cd7adns8	1161	14	has	have	VBZ
cord-023168-cd7adns8	1161	15	a	a	DT
cord-023168-cd7adns8	1161	16	high	high	JJ
cord-023168-cd7adns8	1161	17	cure	cure	NN
cord-023168-cd7adns8	1161	18	rate	rate	NN
cord-023168-cd7adns8	1161	19	with	with	IN
cord-023168-cd7adns8	1161	20	early	early	JJ
cord-023168-cd7adns8	1161	21	treatment	treatment	NN
cord-023168-cd7adns8	1161	22	.	.	.
cord-023168-cd7adns8	1162	1	It	-PRON-	PRP
cord-023168-cd7adns8	1162	2	predominantly	predominantly	RB
cord-023168-cd7adns8	1162	3	affects	affect	VBZ
cord-023168-cd7adns8	1162	4	young	young	JJ
cord-023168-cd7adns8	1162	5	adults	adult	NNS
cord-023168-cd7adns8	1162	6	and	and	CC
cord-023168-cd7adns8	1162	7	it	-PRON-	PRP
cord-023168-cd7adns8	1162	8	has	have	VBZ
cord-023168-cd7adns8	1162	9	a	a	DT
cord-023168-cd7adns8	1162	10	high	high	JJ
cord-023168-cd7adns8	1162	11	incidence	incidence	NN
cord-023168-cd7adns8	1162	12	in	in	IN
cord-023168-cd7adns8	1162	13	certain	certain	JJ
cord-023168-cd7adns8	1162	14	ethnic	ethnic	JJ
cord-023168-cd7adns8	1162	15	groups	group	NNS
cord-023168-cd7adns8	1162	16	especially	especially	RB
cord-023168-cd7adns8	1162	17	those	those	DT
cord-023168-cd7adns8	1162	18	of	of	IN
cord-023168-cd7adns8	1162	19	Latin	latin	JJ
cord-023168-cd7adns8	1162	20	American	american	JJ
cord-023168-cd7adns8	1162	21	descent	descent	NN
cord-023168-cd7adns8	1162	22	.	.	.
cord-023168-cd7adns8	1163	1	315	315	CD
cord-023168-cd7adns8	1163	2	A	a	DT
cord-023168-cd7adns8	1163	3	treatment	treatment	NN
cord-023168-cd7adns8	1163	4	protocol	protocol	NN
cord-023168-cd7adns8	1163	5	which	which	WDT
cord-023168-cd7adns8	1163	6	includes	include	VBZ
cord-023168-cd7adns8	1163	7	all	all	DT
cord-023168-cd7adns8	1163	8	-	-	HYPH
cord-023168-cd7adns8	1163	9	transretinoic	transretinoic	NN
cord-023168-cd7adns8	1163	10	acid	acid	NN
cord-023168-cd7adns8	1163	11	with	with	IN
cord-023168-cd7adns8	1163	12	combination	combination	NN
cord-023168-cd7adns8	1163	13	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1163	14	has	have	VBZ
cord-023168-cd7adns8	1163	15	been	be	VBN
cord-023168-cd7adns8	1163	16	developed	develop	VBN
cord-023168-cd7adns8	1163	17	which	which	WDT
cord-023168-cd7adns8	1163	18	is	be	VBZ
cord-023168-cd7adns8	1163	19	feasible	feasible	JJ
cord-023168-cd7adns8	1163	20	in	in	IN
cord-023168-cd7adns8	1163	21	low	low	JJ
cord-023168-cd7adns8	1163	22	-	-	HYPH
cord-023168-cd7adns8	1163	23	income	income	NN
cord-023168-cd7adns8	1163	24	countries	country	NNS
cord-023168-cd7adns8	1163	25	.	.	.
cord-023168-cd7adns8	1164	1	315	315	CD
cord-023168-cd7adns8	1164	2	,	,	,
cord-023168-cd7adns8	1164	3	315	315	CD
cord-023168-cd7adns8	1165	1	Another	another	DT
cord-023168-cd7adns8	1165	2	regimen	regimen	NN
cord-023168-cd7adns8	1165	3	based	base	VBN
cord-023168-cd7adns8	1165	4	on	on	IN
cord-023168-cd7adns8	1165	5	intravenous	intravenous	JJ
cord-023168-cd7adns8	1165	6	arsenic	arsenic	NN
cord-023168-cd7adns8	1165	7	trioxide	trioxide	NN
cord-023168-cd7adns8	1165	8	has	have	VBZ
cord-023168-cd7adns8	1165	9	been	be	VBN
cord-023168-cd7adns8	1165	10	developed	develop	VBN
cord-023168-cd7adns8	1165	11	in	in	IN
cord-023168-cd7adns8	1165	12	India	India	NNP
cord-023168-cd7adns8	1165	13	,	,	,
cord-023168-cd7adns8	1165	14	316	316	CD
cord-023168-cd7adns8	1165	15	,	,	,
cord-023168-cd7adns8	1165	16	317	317	CD
cord-023168-cd7adns8	1165	17	which	which	WDT
cord-023168-cd7adns8	1165	18	has	have	VBZ
cord-023168-cd7adns8	1165	19	an	an	DT
cord-023168-cd7adns8	1165	20	86	86	CD
cord-023168-cd7adns8	1165	21	%	%	NN
cord-023168-cd7adns8	1165	22	response	response	NN
cord-023168-cd7adns8	1165	23	rate	rate	NN
cord-023168-cd7adns8	1165	24	with	with	IN
cord-023168-cd7adns8	1165	25	good	good	JJ
cord-023168-cd7adns8	1165	26	diseasefree	diseasefree	JJ
cord-023168-cd7adns8	1165	27	and	and	CC
cord-023168-cd7adns8	1165	28	overall	overall	JJ
cord-023168-cd7adns8	1165	29	survival	survival	NN
cord-023168-cd7adns8	1165	30	.	.	.
cord-023168-cd7adns8	1166	1	conditions	condition	NNS
cord-023168-cd7adns8	1166	2	that	that	WDT
cord-023168-cd7adns8	1166	3	are	be	VBP
cord-023168-cd7adns8	1166	4	associated	associate	VBN
cord-023168-cd7adns8	1166	5	with	with	IN
cord-023168-cd7adns8	1166	6	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1166	7	such	such	JJ
cord-023168-cd7adns8	1166	8	as	as	IN
cord-023168-cd7adns8	1166	9	HIV	HIV	NNP
cord-023168-cd7adns8	1166	10	infection	infection	NN
cord-023168-cd7adns8	1166	11	,	,	,
cord-023168-cd7adns8	1166	12	and	and	CC
cord-023168-cd7adns8	1166	13	chronic	chronic	JJ
cord-023168-cd7adns8	1166	14	infections	infection	NNS
cord-023168-cd7adns8	1166	15	including	include	VBG
cord-023168-cd7adns8	1166	16	tuberculosis	tuberculosis	NN
cord-023168-cd7adns8	1166	17	301	301	CD
cord-023168-cd7adns8	1166	18	,	,	,
cord-023168-cd7adns8	1166	19	302	302	CD
cord-023168-cd7adns8	1166	20	and	and	CC
cord-023168-cd7adns8	1166	21	helminth	helminth	NN
cord-023168-cd7adns8	1166	22	-	-	HYPH
cord-023168-cd7adns8	1166	23	induced	induce	VBN
cord-023168-cd7adns8	1166	24	eosinophilic	eosinophilic	JJ
cord-023168-cd7adns8	1166	25	myocarditis	myocarditis	NN
cord-023168-cd7adns8	1166	26	.	.	.
cord-023168-cd7adns8	1167	1	303	303	CD
cord-023168-cd7adns8	1167	2	African	African	NNP
cord-023168-cd7adns8	1167	3	Americans	Americans	NNPS
cord-023168-cd7adns8	1167	4	are	be	VBP
cord-023168-cd7adns8	1167	5	more	more	RBR
cord-023168-cd7adns8	1167	6	likely	likely	JJ
cord-023168-cd7adns8	1167	7	to	to	TO
cord-023168-cd7adns8	1167	8	be	be	VB
cord-023168-cd7adns8	1167	9	diagnosed	diagnose	VBN
cord-023168-cd7adns8	1167	10	with	with	IN
cord-023168-cd7adns8	1167	11	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	1167	12	embolism	embolism	NN
cord-023168-cd7adns8	1167	13	rather	rather	RB
cord-023168-cd7adns8	1167	14	than	than	IN
cord-023168-cd7adns8	1167	15	deep	deep	JJ
cord-023168-cd7adns8	1167	16	-	-	HYPH
cord-023168-cd7adns8	1167	17	vein	vein	NN
cord-023168-cd7adns8	1167	18	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1167	19	compared	compare	VBN
cord-023168-cd7adns8	1167	20	to	to	IN
cord-023168-cd7adns8	1167	21	other	other	JJ
cord-023168-cd7adns8	1167	22	racial	racial	JJ
cord-023168-cd7adns8	1167	23	groups	group	NNS
cord-023168-cd7adns8	1167	24	304	304	CD
cord-023168-cd7adns8	1167	25	and	and	CC
cord-023168-cd7adns8	1167	26	African	african	JJ
cord-023168-cd7adns8	1167	27	patients	patient	NNS
cord-023168-cd7adns8	1167	28	with	with	IN
cord-023168-cd7adns8	1167	29	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1167	30	tend	tend	VBP
cord-023168-cd7adns8	1167	31	to	to	TO
cord-023168-cd7adns8	1167	32	be	be	VB
cord-023168-cd7adns8	1167	33	younger	young	JJR
cord-023168-cd7adns8	1167	34	than	than	IN
cord-023168-cd7adns8	1167	35	those	those	DT
cord-023168-cd7adns8	1167	36	reported	report	VBN
cord-023168-cd7adns8	1167	37	in	in	IN
cord-023168-cd7adns8	1167	38	literature	literature	NN
cord-023168-cd7adns8	1167	39	305	305	CD
cord-023168-cd7adns8	1167	40	with	with	IN
cord-023168-cd7adns8	1167	41	higher	high	JJR
cord-023168-cd7adns8	1167	42	mortality	mortality	NN
cord-023168-cd7adns8	1167	43	rates	rate	NNS
cord-023168-cd7adns8	1167	44	(	(	-LRB-
cord-023168-cd7adns8	1167	45	around	around	IN
cord-023168-cd7adns8	1167	46	28	28	CD
cord-023168-cd7adns8	1167	47	%	%	NN
cord-023168-cd7adns8	1167	48	)	)	-RRB-
cord-023168-cd7adns8	1167	49	possibly	possibly	RB
cord-023168-cd7adns8	1167	50	due	due	JJ
cord-023168-cd7adns8	1167	51	to	to	IN
cord-023168-cd7adns8	1167	52	late	late	JJ
cord-023168-cd7adns8	1167	53	presentation	presentation	NN
cord-023168-cd7adns8	1167	54	and	and	CC
cord-023168-cd7adns8	1167	55	poor	poor	JJ
cord-023168-cd7adns8	1167	56	access	access	NN
cord-023168-cd7adns8	1167	57	to	to	IN
cord-023168-cd7adns8	1167	58	health	health	NN
cord-023168-cd7adns8	1167	59	facilities	facility	NNS
cord-023168-cd7adns8	1167	60	.	.	.
cord-023168-cd7adns8	1168	1	Asian	asian	JJ
cord-023168-cd7adns8	1168	2	populations	population	NNS
cord-023168-cd7adns8	1168	3	306	306	CD
cord-023168-cd7adns8	1168	4	-	-	HYPH
cord-023168-cd7adns8	1168	5	308	308	CD
cord-023168-cd7adns8	1168	6	seem	seem	VBP
cord-023168-cd7adns8	1168	7	to	to	TO
cord-023168-cd7adns8	1168	8	have	have	VB
cord-023168-cd7adns8	1168	9	a	a	DT
cord-023168-cd7adns8	1168	10	lower	low	JJR
cord-023168-cd7adns8	1168	11	prevalence	prevalence	NN
cord-023168-cd7adns8	1168	12	of	of	IN
cord-023168-cd7adns8	1168	13	symptomatic	symptomatic	JJ
cord-023168-cd7adns8	1168	14	venous	venous	JJ
cord-023168-cd7adns8	1168	15	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1168	16	compared	compare	VBN
cord-023168-cd7adns8	1168	17	to	to	IN
cord-023168-cd7adns8	1168	18	African	African	NNP
cord-023168-cd7adns8	1168	19	Americans	Americans	NNPS
cord-023168-cd7adns8	1168	20	.	.	.
cord-023168-cd7adns8	1169	1	304	304	CD
cord-023168-cd7adns8	1169	2	Very	very	RB
cord-023168-cd7adns8	1169	3	little	little	JJ
cord-023168-cd7adns8	1169	4	is	be	VBZ
cord-023168-cd7adns8	1169	5	known	know	VBN
cord-023168-cd7adns8	1169	6	about	about	IN
cord-023168-cd7adns8	1169	7	the	the	DT
cord-023168-cd7adns8	1169	8	prevalence	prevalence	NN
cord-023168-cd7adns8	1169	9	of	of	IN
cord-023168-cd7adns8	1169	10	prothrombotic	prothrombotic	JJ
cord-023168-cd7adns8	1169	11	factors	factor	NNS
cord-023168-cd7adns8	1169	12	such	such	JJ
cord-023168-cd7adns8	1169	13	as	as	IN
cord-023168-cd7adns8	1169	14	mutations	mutation	NNS
cord-023168-cd7adns8	1169	15	of	of	IN
cord-023168-cd7adns8	1169	16	the	the	DT
cord-023168-cd7adns8	1169	17	prothrombin	prothrombin	NN
cord-023168-cd7adns8	1169	18	gene	gene	NN
cord-023168-cd7adns8	1169	19	or	or	CC
cord-023168-cd7adns8	1169	20	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1169	21	of	of	IN
cord-023168-cd7adns8	1169	22	antithrombin	antithrombin	NN
cord-023168-cd7adns8	1169	23	,	,	,
cord-023168-cd7adns8	1169	24	protein	protein	NN
cord-023168-cd7adns8	1169	25	C	C	NNP
cord-023168-cd7adns8	1169	26	and	and	CC
cord-023168-cd7adns8	1169	27	protein	protein	NN
cord-023168-cd7adns8	1169	28	S	S	NNP
cord-023168-cd7adns8	1169	29	in	in	IN
cord-023168-cd7adns8	1169	30	tropical	tropical	JJ
cord-023168-cd7adns8	1169	31	countries	country	NNS
cord-023168-cd7adns8	1169	32	,	,	,
cord-023168-cd7adns8	1169	33	although	although	IN
cord-023168-cd7adns8	1169	34	high	high	JJ
cord-023168-cd7adns8	1169	35	rates	rate	NNS
cord-023168-cd7adns8	1169	36	of	of	IN
cord-023168-cd7adns8	1169	37	factor	factor	NN
cord-023168-cd7adns8	1169	38	V	V	NNP
cord-023168-cd7adns8	1169	39	Leiden	Leiden	NNP
cord-023168-cd7adns8	1169	40	,	,	,
cord-023168-cd7adns8	1169	41	a	a	DT
cord-023168-cd7adns8	1169	42	risk	risk	NN
cord-023168-cd7adns8	1169	43	factor	factor	NN
cord-023168-cd7adns8	1169	44	for	for	IN
cord-023168-cd7adns8	1169	45	venous	venous	JJ
cord-023168-cd7adns8	1169	46	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1169	47	,	,	,
cord-023168-cd7adns8	1169	48	have	have	VBP
cord-023168-cd7adns8	1169	49	been	be	VBN
cord-023168-cd7adns8	1169	50	described	describe	VBN
cord-023168-cd7adns8	1169	51	in	in	IN
cord-023168-cd7adns8	1169	52	Tunisia	Tunisia	NNP
cord-023168-cd7adns8	1169	53	.	.	.
cord-023168-cd7adns8	1170	1	309	309	CD
cord-023168-cd7adns8	1170	2	,	,	,
cord-023168-cd7adns8	1170	3	310	310	CD
cord-023168-cd7adns8	1170	4	Lupus	Lupus	NNP
cord-023168-cd7adns8	1170	5	anticoagulant	anticoagulant	NN
cord-023168-cd7adns8	1170	6	and	and	CC
cord-023168-cd7adns8	1170	7	anti	anti	JJ
cord-023168-cd7adns8	1170	8	-	-	JJ
cord-023168-cd7adns8	1170	9	phospholipid	phospholipid	JJ
cord-023168-cd7adns8	1170	10	syndrome	syndrome	NN
cord-023168-cd7adns8	1170	11	,	,	,
cord-023168-cd7adns8	1170	12	which	which	WDT
cord-023168-cd7adns8	1170	13	are	be	VBP
cord-023168-cd7adns8	1170	14	associated	associate	VBN
cord-023168-cd7adns8	1170	15	with	with	IN
cord-023168-cd7adns8	1170	16	increased	increase	VBN
cord-023168-cd7adns8	1170	17	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1170	18	risk	risk	NN
cord-023168-cd7adns8	1170	19	,	,	,
cord-023168-cd7adns8	1170	20	are	be	VBP
cord-023168-cd7adns8	1170	21	increased	increase	VBN
cord-023168-cd7adns8	1170	22	in	in	IN
cord-023168-cd7adns8	1170	23	Afro	afro	JJ
cord-023168-cd7adns8	1170	24	-	-	HYPH
cord-023168-cd7adns8	1170	25	Caribbean	caribbean	JJ
cord-023168-cd7adns8	1170	26	populations	population	NNS
cord-023168-cd7adns8	1170	27	,	,	,
cord-023168-cd7adns8	1170	28	especially	especially	RB
cord-023168-cd7adns8	1170	29	in	in	IN
cord-023168-cd7adns8	1170	30	the	the	DT
cord-023168-cd7adns8	1170	31	presence	presence	NN
cord-023168-cd7adns8	1170	32	of	of	IN
cord-023168-cd7adns8	1170	33	HIV	HIV	NNP
cord-023168-cd7adns8	1170	34	,	,	,
cord-023168-cd7adns8	1170	35	and	and	CC
cord-023168-cd7adns8	1170	36	have	have	VBP
cord-023168-cd7adns8	1170	37	also	also	RB
cord-023168-cd7adns8	1170	38	been	be	VBN
cord-023168-cd7adns8	1170	39	described	describe	VBN
cord-023168-cd7adns8	1170	40	in	in	IN
cord-023168-cd7adns8	1170	41	Nigerian	nigerian	JJ
cord-023168-cd7adns8	1170	42	women	woman	NNS
cord-023168-cd7adns8	1170	43	with	with	IN
cord-023168-cd7adns8	1170	44	pre	pre	JJ
cord-023168-cd7adns8	1170	45	-	-	JJ
cord-023168-cd7adns8	1170	46	eclampsia	eclampsia	JJ
cord-023168-cd7adns8	1170	47	.	.	.
cord-023168-cd7adns8	1171	1	311	311	CD
cord-023168-cd7adns8	1171	2	,	,	,
cord-023168-cd7adns8	1171	3	312	312	CD
cord-023168-cd7adns8	1172	1	The	the	DT
cord-023168-cd7adns8	1172	2	management	management	NN
cord-023168-cd7adns8	1172	3	of	of	IN
cord-023168-cd7adns8	1172	4	venous	venous	JJ
cord-023168-cd7adns8	1172	5	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1172	6	is	be	VBZ
cord-023168-cd7adns8	1172	7	initially	initially	RB
cord-023168-cd7adns8	1172	8	with	with	IN
cord-023168-cd7adns8	1172	9	heparin	heparin	NN
cord-023168-cd7adns8	1172	10	and	and	CC
cord-023168-cd7adns8	1172	11	then	then	RB
cord-023168-cd7adns8	1172	12	with	with	IN
cord-023168-cd7adns8	1172	13	warfarin	warfarin	NN
cord-023168-cd7adns8	1172	14	for	for	IN
cord-023168-cd7adns8	1172	15	3	3	CD
cord-023168-cd7adns8	1172	16	-	-	SYM
cord-023168-cd7adns8	1172	17	6	6	CD
cord-023168-cd7adns8	1172	18	months	month	NNS
cord-023168-cd7adns8	1172	19	.	.	.
cord-023168-cd7adns8	1173	1	Compliance	compliance	NN
cord-023168-cd7adns8	1173	2	may	may	MD
cord-023168-cd7adns8	1173	3	be	be	VB
cord-023168-cd7adns8	1173	4	difficult	difficult	JJ
cord-023168-cd7adns8	1173	5	in	in	IN
cord-023168-cd7adns8	1173	6	low	low	JJ
cord-023168-cd7adns8	1173	7	-	-	HYPH
cord-023168-cd7adns8	1173	8	resource	resource	NN
cord-023168-cd7adns8	1173	9	settings	setting	NNS
cord-023168-cd7adns8	1173	10	because	because	IN
cord-023168-cd7adns8	1173	11	of	of	IN
cord-023168-cd7adns8	1173	12	the	the	DT
cord-023168-cd7adns8	1173	13	requirement	requirement	NN
cord-023168-cd7adns8	1173	14	for	for	IN
cord-023168-cd7adns8	1173	15	regular	regular	JJ
cord-023168-cd7adns8	1173	16	monitoring	monitoring	NN
cord-023168-cd7adns8	1173	17	of	of	IN
cord-023168-cd7adns8	1173	18	warfarin	warfarin	NN
cord-023168-cd7adns8	1173	19	.	.	.
cord-023168-cd7adns8	1174	1	It	-PRON-	PRP
cord-023168-cd7adns8	1174	2	is	be	VBZ
cord-023168-cd7adns8	1174	3	therefore	therefore	RB
cord-023168-cd7adns8	1174	4	important	important	JJ
cord-023168-cd7adns8	1174	5	to	to	TO
cord-023168-cd7adns8	1174	6	try	try	VB
cord-023168-cd7adns8	1174	7	to	to	TO
cord-023168-cd7adns8	1174	8	prevent	prevent	VB
cord-023168-cd7adns8	1174	9	thromboses	thrombose	NNS
cord-023168-cd7adns8	1174	10	by	by	IN
cord-023168-cd7adns8	1174	11	removing	remove	VBG
cord-023168-cd7adns8	1174	12	any	any	DT
cord-023168-cd7adns8	1174	13	underlying	underlying	JJ
cord-023168-cd7adns8	1174	14	risk	risk	NN
cord-023168-cd7adns8	1174	15	factors	factor	NNS
cord-023168-cd7adns8	1174	16	and	and	CC
cord-023168-cd7adns8	1174	17	by	by	IN
cord-023168-cd7adns8	1174	18	treating	treat	VBG
cord-023168-cd7adns8	1174	19	individuals	individual	NNS
cord-023168-cd7adns8	1174	20	at	at	IN
cord-023168-cd7adns8	1174	21	risk	risk	NN
cord-023168-cd7adns8	1174	22	of	of	IN
cord-023168-cd7adns8	1174	23	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1174	24	with	with	IN
cord-023168-cd7adns8	1174	25	a	a	DT
cord-023168-cd7adns8	1174	26	short	short	JJ
cord-023168-cd7adns8	1174	27	course	course	NN
cord-023168-cd7adns8	1174	28	of	of	IN
cord-023168-cd7adns8	1174	29	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	1174	30	heparin	heparin	NN
cord-023168-cd7adns8	1174	31	to	to	TO
cord-023168-cd7adns8	1174	32	cover	cover	VB
cord-023168-cd7adns8	1174	33	procedures	procedure	NNS
cord-023168-cd7adns8	1174	34	known	know	VBN
cord-023168-cd7adns8	1174	35	to	to	TO
cord-023168-cd7adns8	1174	36	be	be	VB
cord-023168-cd7adns8	1174	37	associated	associate	VBN
cord-023168-cd7adns8	1174	38	with	with	IN
cord-023168-cd7adns8	1174	39	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1174	40	risk	risk	NN
cord-023168-cd7adns8	1174	41	.	.	.
cord-023168-cd7adns8	1175	1	This	this	DT
cord-023168-cd7adns8	1175	2	can	can	MD
cord-023168-cd7adns8	1175	3	present	present	VB
cord-023168-cd7adns8	1175	4	as	as	RB
cord-023168-cd7adns8	1175	5	venous	venous	JJ
cord-023168-cd7adns8	1175	6	or	or	CC
cord-023168-cd7adns8	1175	7	arterial	arterial	JJ
cord-023168-cd7adns8	1175	8	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1175	9	and	and	CC
cord-023168-cd7adns8	1175	10	it	-PRON-	PRP
cord-023168-cd7adns8	1175	11	may	may	MD
cord-023168-cd7adns8	1175	12	be	be	VB
cord-023168-cd7adns8	1175	13	inherited	inherit	VBN
cord-023168-cd7adns8	1175	14	(	(	-LRB-
cord-023168-cd7adns8	1175	15	e.g.	e.g.	JJ
cord-023168-cd7adns8	1175	16	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1175	17	of	of	IN
cord-023168-cd7adns8	1175	18	thrombin	thrombin	NN
cord-023168-cd7adns8	1175	19	,	,	,
cord-023168-cd7adns8	1175	20	protein	protein	NN
cord-023168-cd7adns8	1175	21	S	S	NNP
cord-023168-cd7adns8	1175	22	or	or	CC
cord-023168-cd7adns8	1175	23	protein	protein	NN
cord-023168-cd7adns8	1175	24	C	C	NNP
cord-023168-cd7adns8	1175	25	)	)	-RRB-
cord-023168-cd7adns8	1175	26	or	or	CC
cord-023168-cd7adns8	1175	27	acquired	acquire	VBN
cord-023168-cd7adns8	1175	28	(	(	-LRB-
cord-023168-cd7adns8	1175	29	e.g.	e.g.	IN
cord-023168-cd7adns8	1175	30	antiphospholipids	antiphospholipids	NNP
cord-023168-cd7adns8	1175	31	)	)	-RRB-
cord-023168-cd7adns8	1175	32	.	.	.
cord-023168-cd7adns8	1176	1	The	the	DT
cord-023168-cd7adns8	1176	2	patient	patient	NN
cord-023168-cd7adns8	1176	3	's	's	POS
cord-023168-cd7adns8	1176	4	personal	personal	JJ
cord-023168-cd7adns8	1176	5	and	and	CC
cord-023168-cd7adns8	1176	6	family	family	NN
cord-023168-cd7adns8	1176	7	history	history	NN
cord-023168-cd7adns8	1176	8	,	,	,
cord-023168-cd7adns8	1176	9	and	and	CC
cord-023168-cd7adns8	1176	10	the	the	DT
cord-023168-cd7adns8	1176	11	results	result	NNS
cord-023168-cd7adns8	1176	12	of	of	IN
cord-023168-cd7adns8	1176	13	clinical	clinical	JJ
cord-023168-cd7adns8	1176	14	and	and	CC
cord-023168-cd7adns8	1176	15	imaging	image	VBG
cord-023168-cd7adns8	1176	16	examinations	examination	NNS
cord-023168-cd7adns8	1176	17	to	to	TO
cord-023168-cd7adns8	1176	18	confirm	confirm	VB
cord-023168-cd7adns8	1176	19	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1176	20	,	,	,
cord-023168-cd7adns8	1176	21	may	may	MD
cord-023168-cd7adns8	1176	22	suggest	suggest	VB
cord-023168-cd7adns8	1176	23	the	the	DT
cord-023168-cd7adns8	1176	24	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1176	25	.	.	.
cord-023168-cd7adns8	1177	1	The	the	DT
cord-023168-cd7adns8	1177	2	laboratory	laboratory	NN
cord-023168-cd7adns8	1177	3	tests	test	NNS
cord-023168-cd7adns8	1177	4	needed	need	VBN
cord-023168-cd7adns8	1177	5	to	to	TO
cord-023168-cd7adns8	1177	6	determine	determine	VB
cord-023168-cd7adns8	1177	7	the	the	DT
cord-023168-cd7adns8	1177	8	cause	cause	NN
cord-023168-cd7adns8	1177	9	and	and	CC
cord-023168-cd7adns8	1177	10	classify	classify	VB
cord-023168-cd7adns8	1177	11	the	the	DT
cord-023168-cd7adns8	1177	12	type	type	NN
cord-023168-cd7adns8	1177	13	of	of	IN
cord-023168-cd7adns8	1177	14	thrombophilia	thrombophilia	NNP
cord-023168-cd7adns8	1177	15	,	,	,
cord-023168-cd7adns8	1177	16	and	and	CC
cord-023168-cd7adns8	1177	17	their	-PRON-	PRP$
cord-023168-cd7adns8	1177	18	interpretation	interpretation	NN
cord-023168-cd7adns8	1177	19	,	,	,
cord-023168-cd7adns8	1177	20	are	be	VBP
cord-023168-cd7adns8	1177	21	complex	complex	JJ
cord-023168-cd7adns8	1177	22	,	,	,
cord-023168-cd7adns8	1177	23	so	so	IN
cord-023168-cd7adns8	1177	24	patients	patient	NNS
cord-023168-cd7adns8	1177	25	with	with	IN
cord-023168-cd7adns8	1177	26	recurrent	recurrent	JJ
cord-023168-cd7adns8	1177	27	or	or	CC
cord-023168-cd7adns8	1177	28	unusual	unusual	JJ
cord-023168-cd7adns8	1177	29	thromboses	thrombose	NNS
cord-023168-cd7adns8	1177	30	should	should	MD
cord-023168-cd7adns8	1177	31	be	be	VB
cord-023168-cd7adns8	1177	32	referred	refer	VBN
cord-023168-cd7adns8	1177	33	to	to	IN
cord-023168-cd7adns8	1177	34	a	a	DT
cord-023168-cd7adns8	1177	35	specialist	specialist	JJ
cord-023168-cd7adns8	1177	36	centre	centre	NN
cord-023168-cd7adns8	1177	37	.	.	.
cord-023168-cd7adns8	1178	1	Haematological	Haematological	NNP
cord-023168-cd7adns8	1178	2	malignancies	malignancy	NNS
cord-023168-cd7adns8	1178	3	are	be	VBP
cord-023168-cd7adns8	1178	4	predominantly	predominantly	RB
cord-023168-cd7adns8	1178	5	leukaemias	leukaemias	JJ
cord-023168-cd7adns8	1178	6	,	,	,
cord-023168-cd7adns8	1178	7	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1178	8	and	and	CC
cord-023168-cd7adns8	1178	9	myelomas	myeloma	NNS
cord-023168-cd7adns8	1178	10	.	.	.
cord-023168-cd7adns8	1179	1	Some	some	DT
cord-023168-cd7adns8	1179	2	of	of	IN
cord-023168-cd7adns8	1179	3	the	the	DT
cord-023168-cd7adns8	1179	4	general	general	JJ
cord-023168-cd7adns8	1179	5	approaches	approach	NNS
cord-023168-cd7adns8	1179	6	for	for	IN
cord-023168-cd7adns8	1179	7	managing	manage	VBG
cord-023168-cd7adns8	1179	8	these	these	DT
cord-023168-cd7adns8	1179	9	conditions	condition	NNS
cord-023168-cd7adns8	1179	10	in	in	IN
cord-023168-cd7adns8	1179	11	low	low	JJ
cord-023168-cd7adns8	1179	12	-	-	HYPH
cord-023168-cd7adns8	1179	13	income	income	NN
cord-023168-cd7adns8	1179	14	countries	country	NNS
cord-023168-cd7adns8	1179	15	are	be	VBP
cord-023168-cd7adns8	1179	16	outlined	outline	VBN
cord-023168-cd7adns8	1179	17	in	in	IN
cord-023168-cd7adns8	1179	18	Box	Box	NNP
cord-023168-cd7adns8	1179	19	65.21	65.21	CD
cord-023168-cd7adns8	1179	20	313	313	CD
cord-023168-cd7adns8	1179	21	but	but	CC
cord-023168-cd7adns8	1179	22	definitive	definitive	JJ
cord-023168-cd7adns8	1179	23	treatment	treatment	NN
cord-023168-cd7adns8	1179	24	should	should	MD
cord-023168-cd7adns8	1179	25	be	be	VB
cord-023168-cd7adns8	1179	26	undertaken	undertake	VBN
cord-023168-cd7adns8	1179	27	by	by	IN
cord-023168-cd7adns8	1179	28	a	a	DT
cord-023168-cd7adns8	1179	29	specialist	specialist	NN
cord-023168-cd7adns8	1179	30	haematology	haematology	NNP
cord-023168-cd7adns8	1179	31	unit	unit	NN
cord-023168-cd7adns8	1179	32	.	.	.
cord-023168-cd7adns8	1180	1	Leukaemias	Leukaemias	NNP
cord-023168-cd7adns8	1180	2	can	can	MD
cord-023168-cd7adns8	1180	3	be	be	VB
cord-023168-cd7adns8	1180	4	broadly	broadly	RB
cord-023168-cd7adns8	1180	5	classified	classify	VBN
cord-023168-cd7adns8	1180	6	as	as	IN
cord-023168-cd7adns8	1180	7	acute	acute	JJ
cord-023168-cd7adns8	1180	8	or	or	CC
cord-023168-cd7adns8	1180	9	chronic	chronic	JJ
cord-023168-cd7adns8	1180	10	,	,	,
cord-023168-cd7adns8	1180	11	and	and	CC
cord-023168-cd7adns8	1180	12	lymphoid	lymphoid	NN
cord-023168-cd7adns8	1180	13	or	or	CC
cord-023168-cd7adns8	1180	14	myeloid	myeloid	JJ
cord-023168-cd7adns8	1180	15	.	.	.
cord-023168-cd7adns8	1181	1	The	the	DT
cord-023168-cd7adns8	1181	2	presenting	present	VBG
cord-023168-cd7adns8	1181	3	symptoms	symptom	NNS
cord-023168-cd7adns8	1181	4	and	and	CC
cord-023168-cd7adns8	1181	5	signs	sign	NNS
cord-023168-cd7adns8	1181	6	are	be	VBP
cord-023168-cd7adns8	1181	7	related	relate	VBN
cord-023168-cd7adns8	1181	8	to	to	IN
cord-023168-cd7adns8	1181	9	the	the	DT
cord-023168-cd7adns8	1181	10	disturbed	disturbed	JJ
cord-023168-cd7adns8	1181	11	blood	blood	NN
cord-023168-cd7adns8	1181	12	cell	cell	NN
cord-023168-cd7adns8	1181	13	production	production	NN
cord-023168-cd7adns8	1181	14	from	from	IN
cord-023168-cd7adns8	1181	15	the	the	DT
cord-023168-cd7adns8	1181	16	bone	bone	NN
cord-023168-cd7adns8	1181	17	marrow	marrow	NN
cord-023168-cd7adns8	1181	18	due	due	IN
cord-023168-cd7adns8	1181	19	to	to	IN
cord-023168-cd7adns8	1181	20	the	the	DT
cord-023168-cd7adns8	1181	21	effects	effect	NNS
cord-023168-cd7adns8	1181	22	of	of	IN
cord-023168-cd7adns8	1181	23	the	the	DT
cord-023168-cd7adns8	1181	24	malignant	malignant	JJ
cord-023168-cd7adns8	1181	25	cell	cell	NN
cord-023168-cd7adns8	1181	26	clone	clone	NN
cord-023168-cd7adns8	1181	27	(	(	-LRB-
cord-023168-cd7adns8	1181	28	Box	Box	NNP
cord-023168-cd7adns8	1181	29	65.22	65.22	CD
cord-023168-cd7adns8	1181	30	)	)	-RRB-
cord-023168-cd7adns8	1181	31	.	.	.
cord-023168-cd7adns8	1182	1	Acute	acute	JJ
cord-023168-cd7adns8	1182	2	leukaemias	leukaemias	NNP
cord-023168-cd7adns8	1182	3	are	be	VBP
cord-023168-cd7adns8	1182	4	characterized	characterize	VBN
cord-023168-cd7adns8	1182	5	by	by	IN
cord-023168-cd7adns8	1182	6	rapid	rapid	JJ
cord-023168-cd7adns8	1182	7	progression	progression	NN
cord-023168-cd7adns8	1182	8	and	and	CC
cord-023168-cd7adns8	1182	9	poor	poor	JJ
cord-023168-cd7adns8	1182	10	prognosis	prognosis	NN
cord-023168-cd7adns8	1182	11	if	if	IN
cord-023168-cd7adns8	1182	12	left	leave	VBN
cord-023168-cd7adns8	1182	13	untreated	untreated	JJ
cord-023168-cd7adns8	1182	14	whereas	whereas	IN
cord-023168-cd7adns8	1182	15	chronic	chronic	JJ
cord-023168-cd7adns8	1182	16	leukaemias	leukaemias	NNP
cord-023168-cd7adns8	1182	17	generally	generally	RB
cord-023168-cd7adns8	1182	18	follow	follow	VBP
cord-023168-cd7adns8	1182	19	a	a	DT
cord-023168-cd7adns8	1182	20	much	much	RB
cord-023168-cd7adns8	1182	21	slower	slow	JJR
cord-023168-cd7adns8	1182	22	course	course	NN
cord-023168-cd7adns8	1182	23	.	.	.
cord-023168-cd7adns8	1183	1	•	•	NNP
cord-023168-cd7adns8	1184	1	Mobilization	mobilization	NN
cord-023168-cd7adns8	1184	2	of	of	IN
cord-023168-cd7adns8	1184	3	the	the	DT
cord-023168-cd7adns8	1184	4	community	community	NN
cord-023168-cd7adns8	1184	5	(	(	-LRB-
cord-023168-cd7adns8	1184	6	especially	especially	RB
cord-023168-cd7adns8	1184	7	parents	parent	NNS
cord-023168-cd7adns8	1184	8	and	and	CC
cord-023168-cd7adns8	1184	9	families	family	NNS
cord-023168-cd7adns8	1184	10	)	)	-RRB-
cord-023168-cd7adns8	1184	11	to	to	TO
cord-023168-cd7adns8	1184	12	raise	raise	VB
cord-023168-cd7adns8	1184	13	awareness	awareness	NN
cord-023168-cd7adns8	1184	14	among	among	IN
cord-023168-cd7adns8	1184	15	local	local	JJ
cord-023168-cd7adns8	1184	16	councils	council	NNS
cord-023168-cd7adns8	1184	17	and	and	CC
cord-023168-cd7adns8	1184	18	government	government	NN
cord-023168-cd7adns8	1184	19	bodies	body	NNS
cord-023168-cd7adns8	1184	20	about	about	IN
cord-023168-cd7adns8	1184	21	the	the	DT
cord-023168-cd7adns8	1184	22	treatability	treatability	NN
cord-023168-cd7adns8	1184	23	of	of	IN
cord-023168-cd7adns8	1184	24	the	the	DT
cord-023168-cd7adns8	1184	25	cancers	cancer	NNS
cord-023168-cd7adns8	1184	26	and	and	CC
cord-023168-cd7adns8	1184	27	benefits	benefit	NNS
cord-023168-cd7adns8	1184	28	from	from	IN
cord-023168-cd7adns8	1184	29	curing	cure	VBG
cord-023168-cd7adns8	1184	30	them	-PRON-	PRP
cord-023168-cd7adns8	1185	1	•	•	NNP
cord-023168-cd7adns8	1185	2	Find	find	VB
cord-023168-cd7adns8	1185	3	an	an	DT
cord-023168-cd7adns8	1185	4	external	external	JJ
cord-023168-cd7adns8	1185	5	partner	partner	NN
cord-023168-cd7adns8	1185	6	unit	unit	NN
cord-023168-cd7adns8	1185	7	locally	locally	RB
cord-023168-cd7adns8	1185	8	,	,	,
cord-023168-cd7adns8	1185	9	nationally	nationally	RB
cord-023168-cd7adns8	1185	10	or	or	CC
cord-023168-cd7adns8	1185	11	internationally	internationally	RB
cord-023168-cd7adns8	1185	12	which	which	WDT
cord-023168-cd7adns8	1185	13	is	be	VBZ
cord-023168-cd7adns8	1185	14	already	already	RB
cord-023168-cd7adns8	1185	15	well	well	RB
cord-023168-cd7adns8	1185	16	-	-	HYPH
cord-023168-cd7adns8	1185	17	established	establish	VBN
cord-023168-cd7adns8	1185	18	and	and	CC
cord-023168-cd7adns8	1185	19	willing	willing	JJ
cord-023168-cd7adns8	1185	20	to	to	TO
cord-023168-cd7adns8	1185	21	help	help	VB
cord-023168-cd7adns8	1185	22	but	but	CC
cord-023168-cd7adns8	1185	23	will	will	MD
cord-023168-cd7adns8	1185	24	not	not	RB
cord-023168-cd7adns8	1185	25	dictate	dictate	VB
cord-023168-cd7adns8	1185	26	terms	term	NNS
cord-023168-cd7adns8	1186	1	•	•	NNP
cord-023168-cd7adns8	1186	2	Improvement	improvement	NN
cord-023168-cd7adns8	1186	3	of	of	IN
cord-023168-cd7adns8	1186	4	supportive	supportive	JJ
cord-023168-cd7adns8	1186	5	care	care	NN
cord-023168-cd7adns8	1186	6	facilities	facility	NNS
cord-023168-cd7adns8	1186	7	,	,	,
cord-023168-cd7adns8	1186	8	especially	especially	RB
cord-023168-cd7adns8	1186	9	protection	protection	NN
cord-023168-cd7adns8	1186	10	from	from	IN
cord-023168-cd7adns8	1186	11	those	those	DT
cord-023168-cd7adns8	1186	12	with	with	IN
cord-023168-cd7adns8	1186	13	infectious	infectious	JJ
cord-023168-cd7adns8	1186	14	diseases	disease	NNS
cord-023168-cd7adns8	1187	1	•	•	NNP
cord-023168-cd7adns8	1188	1	Development	development	NN
cord-023168-cd7adns8	1188	2	of	of	IN
cord-023168-cd7adns8	1188	3	a	a	DT
cord-023168-cd7adns8	1188	4	safe	safe	JJ
cord-023168-cd7adns8	1188	5	and	and	CC
cord-023168-cd7adns8	1188	6	reliable	reliable	JJ
cord-023168-cd7adns8	1188	7	blood	blood	NN
cord-023168-cd7adns8	1188	8	transfusion	transfusion	NN
cord-023168-cd7adns8	1188	9	service	service	NN
cord-023168-cd7adns8	1189	1	•	•	NNP
cord-023168-cd7adns8	1190	1	Provision	provision	NN
cord-023168-cd7adns8	1190	2	of	of	IN
cord-023168-cd7adns8	1190	3	subsidized	subsidized	JJ
cord-023168-cd7adns8	1190	4	travel	travel	NN
cord-023168-cd7adns8	1190	5	,	,	,
cord-023168-cd7adns8	1190	6	and	and	CC
cord-023168-cd7adns8	1190	7	satellite	satellite	NN
cord-023168-cd7adns8	1190	8	clinics	clinic	NNS
cord-023168-cd7adns8	1190	9	to	to	TO
cord-023168-cd7adns8	1190	10	lessen	lessen	VB
cord-023168-cd7adns8	1190	11	the	the	DT
cord-023168-cd7adns8	1190	12	burden	burden	NN
cord-023168-cd7adns8	1191	1	•	•	NNP
cord-023168-cd7adns8	1192	1	Development	development	NN
cord-023168-cd7adns8	1192	2	of	of	IN
cord-023168-cd7adns8	1192	3	appropriate	appropriate	JJ
cord-023168-cd7adns8	1192	4	protocols	protocol	NNS
cord-023168-cd7adns8	1192	5	for	for	IN
cord-023168-cd7adns8	1192	6	each	each	DT
cord-023168-cd7adns8	1192	7	disease	disease	NN
cord-023168-cd7adns8	1192	8	entity	entity	NN
cord-023168-cd7adns8	1192	9	which	which	WDT
cord-023168-cd7adns8	1192	10	is	be	VBZ
cord-023168-cd7adns8	1192	11	locally	locally	RB
cord-023168-cd7adns8	1192	12	practicable	practicable	JJ
cord-023168-cd7adns8	1192	13	with	with	IN
cord-023168-cd7adns8	1192	14	minimum	minimum	JJ
cord-023168-cd7adns8	1192	15	cost	cost	NN
cord-023168-cd7adns8	1192	16	and	and	CC
cord-023168-cd7adns8	1192	17	maximum	maximum	JJ
cord-023168-cd7adns8	1192	18	efficacy	efficacy	NN
cord-023168-cd7adns8	1193	1	•	•	NNP
cord-023168-cd7adns8	1194	1	Development	development	NN
cord-023168-cd7adns8	1194	2	of	of	IN
cord-023168-cd7adns8	1194	3	medical	medical	JJ
cord-023168-cd7adns8	1194	4	,	,	,
cord-023168-cd7adns8	1194	5	nursing	nursing	NN
cord-023168-cd7adns8	1194	6	and	and	CC
cord-023168-cd7adns8	1194	7	paramedical	paramedical	JJ
cord-023168-cd7adns8	1194	8	expertise	expertise	NN
cord-023168-cd7adns8	1194	9	in	in	IN
cord-023168-cd7adns8	1194	10	the	the	DT
cord-023168-cd7adns8	1194	11	diseases	disease	NNS
cord-023168-cd7adns8	1194	12	to	to	TO
cord-023168-cd7adns8	1194	13	be	be	VB
cord-023168-cd7adns8	1194	14	treated	treat	VBN
cord-023168-cd7adns8	1194	15	-initially	-initially	RB
cord-023168-cd7adns8	1194	16	by	by	IN
cord-023168-cd7adns8	1194	17	offering	offer	VBG
cord-023168-cd7adns8	1194	18	visiting	visit	VBG
cord-023168-cd7adns8	1194	19	fellowships	fellowship	NNS
cord-023168-cd7adns8	1194	20	and	and	CC
cord-023168-cd7adns8	1194	21	in	in	IN
cord-023168-cd7adns8	1194	22	the	the	DT
cord-023168-cd7adns8	1194	23	long	long	JJ
cord-023168-cd7adns8	1194	24	term	term	NN
cord-023168-cd7adns8	1194	25	for	for	IN
cord-023168-cd7adns8	1194	26	the	the	DT
cord-023168-cd7adns8	1194	27	trained	train	VBN
cord-023168-cd7adns8	1194	28	individuals	individual	NNS
cord-023168-cd7adns8	1194	29	to	to	TO
cord-023168-cd7adns8	1194	30	arrange	arrange	VB
cord-023168-cd7adns8	1194	31	regional	regional	JJ
cord-023168-cd7adns8	1194	32	and	and	CC
cord-023168-cd7adns8	1194	33	local	local	JJ
cord-023168-cd7adns8	1194	34	teaching	teaching	NN
cord-023168-cd7adns8	1194	35	programmes	programme	NNS
cord-023168-cd7adns8	1195	1	•	•	NNP
cord-023168-cd7adns8	1196	1	Formation	formation	NN
cord-023168-cd7adns8	1196	2	of	of	IN
cord-023168-cd7adns8	1196	3	a	a	DT
cord-023168-cd7adns8	1196	4	cooperative	cooperative	JJ
cord-023168-cd7adns8	1196	5	group	group	NN
cord-023168-cd7adns8	1196	6	bringing	bring	VBG
cord-023168-cd7adns8	1196	7	together	together	RB
cord-023168-cd7adns8	1196	8	all	all	PDT
cord-023168-cd7adns8	1196	9	the	the	DT
cord-023168-cd7adns8	1196	10	professionals	professional	NNS
cord-023168-cd7adns8	1196	11	involved	involve	VBN
cord-023168-cd7adns8	1196	12	in	in	IN
cord-023168-cd7adns8	1196	13	the	the	DT
cord-023168-cd7adns8	1196	14	speciality	speciality	NN
cord-023168-cd7adns8	1196	15	within	within	IN
cord-023168-cd7adns8	1196	16	a	a	DT
cord-023168-cd7adns8	1196	17	country	country	NN
cord-023168-cd7adns8	1196	18	or	or	CC
cord-023168-cd7adns8	1196	19	region	region	NN
cord-023168-cd7adns8	1196	20	to	to	TO
cord-023168-cd7adns8	1196	21	share	share	VB
cord-023168-cd7adns8	1196	22	expertise	expertise	NN
cord-023168-cd7adns8	1196	23	and	and	CC
cord-023168-cd7adns8	1196	24	develop	develop	VB
cord-023168-cd7adns8	1196	25	training	training	NN
cord-023168-cd7adns8	1196	26	programmes	programme	NNS
cord-023168-cd7adns8	1196	27	.	.	.
cord-023168-cd7adns8	1197	1	Acute	acute	JJ
cord-023168-cd7adns8	1197	2	Lymphoblastic	Lymphoblastic	NNP
cord-023168-cd7adns8	1197	3	Leukaemia	Leukaemia	NNP
cord-023168-cd7adns8	1197	4	(	(	-LRB-
cord-023168-cd7adns8	1197	5	ALL	all	DT
cord-023168-cd7adns8	1197	6	)	)	-RRB-
cord-023168-cd7adns8	1197	7	.	.	.
cord-023168-cd7adns8	1198	1	This	this	DT
cord-023168-cd7adns8	1198	2	is	be	VBZ
cord-023168-cd7adns8	1198	3	the	the	DT
cord-023168-cd7adns8	1198	4	most	most	RBS
cord-023168-cd7adns8	1198	5	common	common	JJ
cord-023168-cd7adns8	1198	6	type	type	NN
cord-023168-cd7adns8	1198	7	of	of	IN
cord-023168-cd7adns8	1198	8	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1198	9	in	in	IN
cord-023168-cd7adns8	1198	10	children	child	NNS
cord-023168-cd7adns8	1198	11	.	.	.
cord-023168-cd7adns8	1199	1	It	-PRON-	PRP
cord-023168-cd7adns8	1199	2	has	have	VBZ
cord-023168-cd7adns8	1199	3	a	a	DT
cord-023168-cd7adns8	1199	4	good	good	JJ
cord-023168-cd7adns8	1199	5	prognosis	prognosis	NN
cord-023168-cd7adns8	1199	6	when	when	WRB
cord-023168-cd7adns8	1199	7	treated	treat	VBN
cord-023168-cd7adns8	1199	8	with	with	IN
cord-023168-cd7adns8	1199	9	modern	modern	JJ
cord-023168-cd7adns8	1199	10	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1199	11	protocols	protocol	NNS
cord-023168-cd7adns8	1199	12	with	with	IN
cord-023168-cd7adns8	1199	13	cure	cure	NN
cord-023168-cd7adns8	1199	14	rates	rate	NNS
cord-023168-cd7adns8	1199	15	in	in	IN
cord-023168-cd7adns8	1199	16	the	the	DT
cord-023168-cd7adns8	1199	17	best	good	JJS
cord-023168-cd7adns8	1199	18	centres	centre	NNS
cord-023168-cd7adns8	1199	19	exceeding	exceed	VBG
cord-023168-cd7adns8	1199	20	80	80	CD
cord-023168-cd7adns8	1199	21	%	%	NN
cord-023168-cd7adns8	1199	22	.	.	.
cord-023168-cd7adns8	1200	1	318	318	CD
cord-023168-cd7adns8	1201	1	In	in	IN
cord-023168-cd7adns8	1201	2	low	low	JJ
cord-023168-cd7adns8	1201	3	-	-	HYPH
cord-023168-cd7adns8	1201	4	income	income	NN
cord-023168-cd7adns8	1201	5	countries	country	NNS
cord-023168-cd7adns8	1201	6	,	,	,
cord-023168-cd7adns8	1201	7	cure	cure	NN
cord-023168-cd7adns8	1201	8	rates	rate	NNS
cord-023168-cd7adns8	1201	9	are	be	VBP
cord-023168-cd7adns8	1201	10	much	much	RB
cord-023168-cd7adns8	1201	11	lower	low	JJR
cord-023168-cd7adns8	1201	12	at	at	IN
cord-023168-cd7adns8	1201	13	around	around	IN
cord-023168-cd7adns8	1201	14	35	35	CD
cord-023168-cd7adns8	1201	15	%	%	NN
cord-023168-cd7adns8	1201	16	319	319	CD
cord-023168-cd7adns8	1201	17	primarily	primarily	RB
cord-023168-cd7adns8	1201	18	because	because	IN
cord-023168-cd7adns8	1201	19	of	of	IN
cord-023168-cd7adns8	1201	20	failure	failure	NN
cord-023168-cd7adns8	1201	21	to	to	TO
cord-023168-cd7adns8	1201	22	complete	complete	VB
cord-023168-cd7adns8	1201	23	therapy	therapy	NN
cord-023168-cd7adns8	1201	24	and	and	CC
cord-023168-cd7adns8	1201	25	deaths	death	NNS
cord-023168-cd7adns8	1201	26	caused	cause	VBN
cord-023168-cd7adns8	1201	27	by	by	IN
cord-023168-cd7adns8	1201	28	treatment	treatment	NN
cord-023168-cd7adns8	1201	29	.	.	.
cord-023168-cd7adns8	1202	1	Considerable	considerable	JJ
cord-023168-cd7adns8	1202	2	improvements	improvement	NNS
cord-023168-cd7adns8	1202	3	in	in	IN
cord-023168-cd7adns8	1202	4	ALL	all	DT
cord-023168-cd7adns8	1202	5	outcomes	outcome	NNS
cord-023168-cd7adns8	1202	6	have	have	VBP
cord-023168-cd7adns8	1202	7	been	be	VBN
cord-023168-cd7adns8	1202	8	achieved	achieve	VBN
cord-023168-cd7adns8	1202	9	by	by	IN
cord-023168-cd7adns8	1202	10	twinning	twin	VBG
cord-023168-cd7adns8	1202	11	institutions	institution	NNS
cord-023168-cd7adns8	1202	12	in	in	IN
cord-023168-cd7adns8	1202	13	developing	develop	VBG
cord-023168-cd7adns8	1202	14	countries	country	NNS
cord-023168-cd7adns8	1202	15	with	with	IN
cord-023168-cd7adns8	1202	16	specialist	specialist	JJ
cord-023168-cd7adns8	1202	17	centres	centre	NNS
cord-023168-cd7adns8	1202	18	elsewhere	elsewhere	RB
cord-023168-cd7adns8	1202	19	in	in	IN
cord-023168-cd7adns8	1202	20	the	the	DT
cord-023168-cd7adns8	1202	21	country	country	NN
cord-023168-cd7adns8	1202	22	or	or	CC
cord-023168-cd7adns8	1202	23	internationally	internationally	RB
cord-023168-cd7adns8	1202	24	.	.	.
cord-023168-cd7adns8	1203	1	313	313	CD
cord-023168-cd7adns8	1203	2	Measures	measure	NNS
cord-023168-cd7adns8	1203	3	that	that	WDT
cord-023168-cd7adns8	1203	4	may	may	MD
cord-023168-cd7adns8	1203	5	improve	improve	VB
cord-023168-cd7adns8	1203	6	outcomes	outcome	NNS
cord-023168-cd7adns8	1203	7	focus	focus	VB
cord-023168-cd7adns8	1203	8	on	on	IN
cord-023168-cd7adns8	1203	9	preventing	prevent	VBG
cord-023168-cd7adns8	1203	10	abandonment	abandonment	NN
cord-023168-cd7adns8	1203	11	of	of	IN
cord-023168-cd7adns8	1203	12	therapy	therapy	NN
cord-023168-cd7adns8	1203	13	(	(	-LRB-
cord-023168-cd7adns8	1203	14	e.g.	e.g.	RB
cord-023168-cd7adns8	1203	15	providing	provide	VBG
cord-023168-cd7adns8	1203	16	funding	funding	NN
cord-023168-cd7adns8	1203	17	for	for	IN
cord-023168-cd7adns8	1203	18	transport	transport	NN
cord-023168-cd7adns8	1203	19	,	,	,
cord-023168-cd7adns8	1203	20	satellite	satellite	NN
cord-023168-cd7adns8	1203	21	clinics	clinic	NNS
cord-023168-cd7adns8	1203	22	and	and	CC
cord-023168-cd7adns8	1203	23	support	support	NN
cord-023168-cd7adns8	1203	24	groups	group	NNS
cord-023168-cd7adns8	1203	25	)	)	-RRB-
cord-023168-cd7adns8	1203	26	and	and	CC
cord-023168-cd7adns8	1203	27	prompt	prompt	JJ
cord-023168-cd7adns8	1203	28	treatment	treatment	NN
cord-023168-cd7adns8	1203	29	of	of	IN
cord-023168-cd7adns8	1203	30	infection	infection	NN
cord-023168-cd7adns8	1203	31	.	.	.
cord-023168-cd7adns8	1204	1	320	320	CD
cord-023168-cd7adns8	1204	2	Treatment	treatment	NN
cord-023168-cd7adns8	1204	3	in	in	IN
cord-023168-cd7adns8	1204	4	a	a	DT
cord-023168-cd7adns8	1204	5	dedicated	dedicated	JJ
cord-023168-cd7adns8	1204	6	paediatric	paediatric	JJ
cord-023168-cd7adns8	1204	7	oncology	oncology	NN
cord-023168-cd7adns8	1204	8	unit	unit	NN
cord-023168-cd7adns8	1204	9	using	use	VBG
cord-023168-cd7adns8	1204	10	a	a	DT
cord-023168-cd7adns8	1204	11	comprehensive	comprehensive	JJ
cord-023168-cd7adns8	1204	12	multidisciplinary	multidisciplinary	JJ
cord-023168-cd7adns8	1204	13	team	team	NN
cord-023168-cd7adns8	1204	14	approach	approach	NN
cord-023168-cd7adns8	1204	15	and	and	CC
cord-023168-cd7adns8	1204	16	protocol	protocol	NN
cord-023168-cd7adns8	1204	17	-	-	HYPH
cord-023168-cd7adns8	1204	18	based	base	VBN
cord-023168-cd7adns8	1204	19	therapy	therapy	NN
cord-023168-cd7adns8	1204	20	,	,	,
cord-023168-cd7adns8	1204	21	is	be	VBZ
cord-023168-cd7adns8	1204	22	also	also	RB
cord-023168-cd7adns8	1204	23	associated	associate	VBN
cord-023168-cd7adns8	1204	24	with	with	IN
cord-023168-cd7adns8	1204	25	improved	improved	JJ
cord-023168-cd7adns8	1204	26	outcomes	outcome	NNS
cord-023168-cd7adns8	1204	27	in	in	IN
cord-023168-cd7adns8	1204	28	resource	resource	NN
cord-023168-cd7adns8	1204	29	-	-	HYPH
cord-023168-cd7adns8	1204	30	poor	poor	JJ
cord-023168-cd7adns8	1204	31	settings	setting	NNS
cord-023168-cd7adns8	1204	32	.	.	.
cord-023168-cd7adns8	1205	1	321	321	CD
cord-023168-cd7adns8	1205	2	Chronic	Chronic	NNP
cord-023168-cd7adns8	1205	3	Myeloid	Myeloid	NNP
cord-023168-cd7adns8	1205	4	Leukaemia	Leukaemia	NNP
cord-023168-cd7adns8	1205	5	(	(	-LRB-
cord-023168-cd7adns8	1205	6	CML	CML	NNP
cord-023168-cd7adns8	1205	7	)	)	-RRB-
cord-023168-cd7adns8	1205	8	.	.	.
cord-023168-cd7adns8	1206	1	Management	management	NN
cord-023168-cd7adns8	1206	2	has	have	VBZ
cord-023168-cd7adns8	1206	3	been	be	VBN
cord-023168-cd7adns8	1206	4	revolutionized	revolutionize	VBN
cord-023168-cd7adns8	1206	5	by	by	IN
cord-023168-cd7adns8	1206	6	tyrosine	tyrosine	NN
cord-023168-cd7adns8	1206	7	kinase	kinase	NN
cord-023168-cd7adns8	1206	8	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1206	9	(	(	-LRB-
cord-023168-cd7adns8	1206	10	e.g.	e.g.	RB
cord-023168-cd7adns8	1206	11	imatinib	imatinib	RB
cord-023168-cd7adns8	1206	12	)	)	-RRB-
cord-023168-cd7adns8	1206	13	which	which	WDT
cord-023168-cd7adns8	1206	14	can	can	MD
cord-023168-cd7adns8	1206	15	produce	produce	VB
cord-023168-cd7adns8	1206	16	complete	complete	JJ
cord-023168-cd7adns8	1206	17	remission	remission	NN
cord-023168-cd7adns8	1206	18	in	in	IN
cord-023168-cd7adns8	1206	19	over	over	IN
cord-023168-cd7adns8	1206	20	80	80	CD
cord-023168-cd7adns8	1206	21	%	%	NN
cord-023168-cd7adns8	1206	22	of	of	IN
cord-023168-cd7adns8	1206	23	cases	case	NNS
cord-023168-cd7adns8	1206	24	.	.	.
cord-023168-cd7adns8	1207	1	Once	once	IN
cord-023168-cd7adns8	1207	2	the	the	DT
cord-023168-cd7adns8	1207	3	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1207	4	of	of	IN
cord-023168-cd7adns8	1207	5	CML	CML	NNP
cord-023168-cd7adns8	1207	6	is	be	VBZ
cord-023168-cd7adns8	1207	7	established	establish	VBN
cord-023168-cd7adns8	1207	8	,	,	,
cord-023168-cd7adns8	1207	9	hydroxycarbamide	hydroxycarbamide	NN
cord-023168-cd7adns8	1207	10	can	can	MD
cord-023168-cd7adns8	1207	11	be	be	VB
cord-023168-cd7adns8	1207	12	used	use	VBN
cord-023168-cd7adns8	1207	13	to	to	TO
cord-023168-cd7adns8	1207	14	reduce	reduce	VB
cord-023168-cd7adns8	1207	15	the	the	DT
cord-023168-cd7adns8	1207	16	white	white	JJ
cord-023168-cd7adns8	1207	17	cell	cell	NN
cord-023168-cd7adns8	1207	18	count	count	NN
cord-023168-cd7adns8	1207	19	,	,	,
cord-023168-cd7adns8	1207	20	followed	follow	VBN
cord-023168-cd7adns8	1207	21	by	by	IN
cord-023168-cd7adns8	1207	22	treatment	treatment	NN
cord-023168-cd7adns8	1207	23	with	with	IN
cord-023168-cd7adns8	1207	24	a	a	DT
cord-023168-cd7adns8	1207	25	tyrosine	tyrosine	NN
cord-023168-cd7adns8	1207	26	kinase	kinase	NN
cord-023168-cd7adns8	1207	27	inhibitor	inhibitor	NN
cord-023168-cd7adns8	1207	28	.	.	.
cord-023168-cd7adns8	1208	1	Manufacturers	manufacturer	NNS
cord-023168-cd7adns8	1208	2	will	will	MD
cord-023168-cd7adns8	1208	3	provide	provide	VB
cord-023168-cd7adns8	1208	4	the	the	DT
cord-023168-cd7adns8	1208	5	drug	drug	NN
cord-023168-cd7adns8	1208	6	free	free	JJ
cord-023168-cd7adns8	1208	7	of	of	IN
cord-023168-cd7adns8	1208	8	charge	charge	NN
cord-023168-cd7adns8	1208	9	to	to	IN
cord-023168-cd7adns8	1208	10	patients	patient	NNS
cord-023168-cd7adns8	1208	11	in	in	IN
cord-023168-cd7adns8	1208	12	low	low	JJ
cord-023168-cd7adns8	1208	13	-	-	HYPH
cord-023168-cd7adns8	1208	14	income	income	NN
cord-023168-cd7adns8	1208	15	countries	country	NNS
cord-023168-cd7adns8	1208	16	with	with	IN
cord-023168-cd7adns8	1208	17	confirmed	confirm	VBN
cord-023168-cd7adns8	1208	18	CML	CML	NNP
cord-023168-cd7adns8	1208	19	and	and	CC
cord-023168-cd7adns8	1208	20	generic	generic	JJ
cord-023168-cd7adns8	1208	21	forms	form	NNS
cord-023168-cd7adns8	1208	22	of	of	IN
cord-023168-cd7adns8	1208	23	tyrosine	tyrosine	NN
cord-023168-cd7adns8	1208	24	kinase	kinase	NN
cord-023168-cd7adns8	1208	25	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1208	26	are	be	VBP
cord-023168-cd7adns8	1208	27	now	now	RB
cord-023168-cd7adns8	1208	28	becoming	become	VBG
cord-023168-cd7adns8	1208	29	available	available	JJ
cord-023168-cd7adns8	1208	30	.	.	.
cord-023168-cd7adns8	1209	1	Chronic	Chronic	NNP
cord-023168-cd7adns8	1209	2	Lymphocytic	Lymphocytic	NNP
cord-023168-cd7adns8	1209	3	Leukaemia	Leukaemia	NNP
cord-023168-cd7adns8	1209	4	(	(	-LRB-
cord-023168-cd7adns8	1209	5	CLL	CLL	NNP
cord-023168-cd7adns8	1209	6	)	)	-RRB-
cord-023168-cd7adns8	1209	7	.	.	.
cord-023168-cd7adns8	1210	1	This	this	DT
cord-023168-cd7adns8	1210	2	occurs	occur	VBZ
cord-023168-cd7adns8	1210	3	predominantly	predominantly	RB
cord-023168-cd7adns8	1210	4	in	in	IN
cord-023168-cd7adns8	1210	5	older	old	JJR
cord-023168-cd7adns8	1210	6	people	people	NNS
cord-023168-cd7adns8	1210	7	and	and	CC
cord-023168-cd7adns8	1210	8	usually	usually	RB
cord-023168-cd7adns8	1210	9	presents	present	VBZ
cord-023168-cd7adns8	1210	10	with	with	IN
cord-023168-cd7adns8	1210	11	lymphadenopathy	lymphadenopathy	JJ
cord-023168-cd7adns8	1210	12	and	and	CC
cord-023168-cd7adns8	1210	13	recurrent	recurrent	JJ
cord-023168-cd7adns8	1210	14	infections	infection	NNS
cord-023168-cd7adns8	1210	15	.	.	.
cord-023168-cd7adns8	1211	1	Treatment	treatment	NN
cord-023168-cd7adns8	1211	2	is	be	VBZ
cord-023168-cd7adns8	1211	3	with	with	IN
cord-023168-cd7adns8	1211	4	chlorambucil	chlorambucil	NNP
cord-023168-cd7adns8	1211	5	and	and	CC
cord-023168-cd7adns8	1211	6	prednisolone	prednisolone	NN
cord-023168-cd7adns8	1211	7	although	although	IN
cord-023168-cd7adns8	1211	8	aggressive	aggressive	JJ
cord-023168-cd7adns8	1211	9	forms	form	NNS
cord-023168-cd7adns8	1211	10	require	require	VBP
cord-023168-cd7adns8	1211	11	combination	combination	NN
cord-023168-cd7adns8	1211	12	therapy	therapy	NN
cord-023168-cd7adns8	1211	13	with	with	IN
cord-023168-cd7adns8	1211	14	rituximab	rituximab	NN
cord-023168-cd7adns8	1211	15	,	,	,
cord-023168-cd7adns8	1211	16	fludarabine	fludarabine	NN
cord-023168-cd7adns8	1211	17	and	and	CC
cord-023168-cd7adns8	1211	18	cyclophosphamide	cyclophosphamide	NN
cord-023168-cd7adns8	1211	19	.	.	.
cord-023168-cd7adns8	1212	1	Treatment	treatment	NN
cord-023168-cd7adns8	1212	2	is	be	VBZ
cord-023168-cd7adns8	1212	3	generally	generally	RB
cord-023168-cd7adns8	1212	4	not	not	RB
cord-023168-cd7adns8	1212	5	curative	curative	JJ
cord-023168-cd7adns8	1212	6	but	but	CC
cord-023168-cd7adns8	1212	7	the	the	DT
cord-023168-cd7adns8	1212	8	disease	disease	NN
cord-023168-cd7adns8	1212	9	may	may	MD
cord-023168-cd7adns8	1212	10	be	be	VB
cord-023168-cd7adns8	1212	11	indolent	indolent	JJ
cord-023168-cd7adns8	1212	12	and	and	CC
cord-023168-cd7adns8	1212	13	drugs	drug	NNS
cord-023168-cd7adns8	1212	14	may	may	MD
cord-023168-cd7adns8	1212	15	only	only	RB
cord-023168-cd7adns8	1212	16	be	be	VB
cord-023168-cd7adns8	1212	17	required	require	VBN
cord-023168-cd7adns8	1212	18	if	if	IN
cord-023168-cd7adns8	1212	19	the	the	DT
cord-023168-cd7adns8	1212	20	patient	patient	NN
cord-023168-cd7adns8	1212	21	has	have	VBZ
cord-023168-cd7adns8	1212	22	symptoms	symptom	NNS
cord-023168-cd7adns8	1212	23	or	or	CC
cord-023168-cd7adns8	1212	24	if	if	IN
cord-023168-cd7adns8	1212	25	there	there	EX
cord-023168-cd7adns8	1212	26	is	be	VBZ
cord-023168-cd7adns8	1212	27	a	a	DT
cord-023168-cd7adns8	1212	28	risk	risk	NN
cord-023168-cd7adns8	1212	29	of	of	IN
cord-023168-cd7adns8	1212	30	hyperviscosity	hyperviscosity	NN
cord-023168-cd7adns8	1212	31	from	from	IN
cord-023168-cd7adns8	1212	32	a	a	DT
cord-023168-cd7adns8	1212	33	very	very	RB
cord-023168-cd7adns8	1212	34	high	high	JJ
cord-023168-cd7adns8	1212	35	lymphocyte	lymphocyte	NN
cord-023168-cd7adns8	1212	36	count	count	NN
cord-023168-cd7adns8	1212	37	.	.	.
cord-023168-cd7adns8	1213	1	Approximately	approximately	RB
cord-023168-cd7adns8	1213	2	30	30	CD
cord-023168-cd7adns8	1213	3	000	000	CD
cord-023168-cd7adns8	1213	4	cases	case	NNS
cord-023168-cd7adns8	1213	5	of	of	IN
cord-023168-cd7adns8	1213	6	non	non	JJ
cord-023168-cd7adns8	1213	7	-	-	JJ
cord-023168-cd7adns8	1213	8	Hodgkin	hodgkin	JJ
cord-023168-cd7adns8	1213	9	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1213	10	(	(	-LRB-
cord-023168-cd7adns8	1213	11	NHL	NHL	NNP
cord-023168-cd7adns8	1213	12	)	)	-RRB-
cord-023168-cd7adns8	1213	13	occur	occur	VBP
cord-023168-cd7adns8	1213	14	in	in	IN
cord-023168-cd7adns8	1213	15	the	the	DT
cord-023168-cd7adns8	1213	16	equatorial	equatorial	JJ
cord-023168-cd7adns8	1213	17	belt	belt	NN
cord-023168-cd7adns8	1213	18	of	of	IN
cord-023168-cd7adns8	1213	19	Africa	Africa	NNP
cord-023168-cd7adns8	1213	20	each	each	DT
cord-023168-cd7adns8	1213	21	year	year	NN
cord-023168-cd7adns8	1214	1	(	(	-LRB-
cord-023168-cd7adns8	1214	2	Table	table	NN
cord-023168-cd7adns8	1214	3	65	65	CD
cord-023168-cd7adns8	1214	4	.11	.11	NFP
cord-023168-cd7adns8	1214	5	)	)	-RRB-
cord-023168-cd7adns8	1214	6	.	.	.
cord-023168-cd7adns8	1215	1	322	322	LS
cord-023168-cd7adns8	1215	2	There	there	EX
cord-023168-cd7adns8	1215	3	are	be	VBP
cord-023168-cd7adns8	1215	4	marked	mark	VBN
cord-023168-cd7adns8	1215	5	geographical	geographical	JJ
cord-023168-cd7adns8	1215	6	variations	variation	NNS
cord-023168-cd7adns8	1215	7	in	in	IN
cord-023168-cd7adns8	1215	8	prevalence	prevalence	NN
cord-023168-cd7adns8	1215	9	but	but	CC
cord-023168-cd7adns8	1215	10	up	up	IN
cord-023168-cd7adns8	1215	11	to	to	TO
cord-023168-cd7adns8	1215	12	50	50	CD
cord-023168-cd7adns8	1215	13	%	%	NN
cord-023168-cd7adns8	1215	14	are	be	VBP
cord-023168-cd7adns8	1215	15	thought	think	VBN
cord-023168-cd7adns8	1215	16	to	to	TO
cord-023168-cd7adns8	1215	17	be	be	VB
cord-023168-cd7adns8	1215	18	related	relate	VBN
cord-023168-cd7adns8	1215	19	to	to	IN
cord-023168-cd7adns8	1215	20	HIV	HIV	NNP
cord-023168-cd7adns8	1215	21	infection	infection	NN
cord-023168-cd7adns8	1215	22	.	.	.
cord-023168-cd7adns8	1216	1	322	322	CD
cord-023168-cd7adns8	1216	2	Burkitt	Burkitt	NNP
cord-023168-cd7adns8	1216	3	's	's	POS
cord-023168-cd7adns8	1216	4	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1216	5	,	,	,
cord-023168-cd7adns8	1216	6	a	a	DT
cord-023168-cd7adns8	1216	7	B	b	NN
cord-023168-cd7adns8	1216	8	-	-	HYPH
cord-023168-cd7adns8	1216	9	cell	cell	NN
cord-023168-cd7adns8	1216	10	NHL	NHL	NNP
cord-023168-cd7adns8	1216	11	,	,	,
cord-023168-cd7adns8	1216	12	was	be	VBD
cord-023168-cd7adns8	1216	13	originally	originally	RB
cord-023168-cd7adns8	1216	14	described	describe	VBN
cord-023168-cd7adns8	1216	15	in	in	IN
cord-023168-cd7adns8	1216	16	children	child	NNS
cord-023168-cd7adns8	1216	17	from	from	IN
cord-023168-cd7adns8	1216	18	Africa	Africa	NNP
cord-023168-cd7adns8	1216	19	and	and	CC
cord-023168-cd7adns8	1216	20	has	have	VBZ
cord-023168-cd7adns8	1216	21	an	an	DT
cord-023168-cd7adns8	1216	22	estimated	estimate	VBN
cord-023168-cd7adns8	1216	23	incidence	incidence	NN
cord-023168-cd7adns8	1216	24	of	of	IN
cord-023168-cd7adns8	1216	25	30	30	CD
cord-023168-cd7adns8	1216	26	-	-	SYM
cord-023168-cd7adns8	1216	27	70	70	CD
cord-023168-cd7adns8	1216	28	per	per	IN
cord-023168-cd7adns8	1216	29	million	million	CD
cord-023168-cd7adns8	1216	30	.	.	.
cord-023168-cd7adns8	1217	1	Lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1217	2	are	be	VBP
cord-023168-cd7adns8	1217	3	broadly	broadly	RB
cord-023168-cd7adns8	1217	4	classified	classify	VBN
cord-023168-cd7adns8	1217	5	into	into	IN
cord-023168-cd7adns8	1217	6	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1217	7	's	's	POS
cord-023168-cd7adns8	1217	8	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1217	9	and	and	CC
cord-023168-cd7adns8	1217	10	NHL	NHL	NNP
cord-023168-cd7adns8	1217	11	;	;	:
cord-023168-cd7adns8	1217	12	NHL	NHL	NNP
cord-023168-cd7adns8	1217	13	are	be	VBP
cord-023168-cd7adns8	1217	14	divided	divide	VBN
cord-023168-cd7adns8	1217	15	into	into	IN
cord-023168-cd7adns8	1217	16	B	b	NN
cord-023168-cd7adns8	1217	17	-	-	HYPH
cord-023168-cd7adns8	1217	18	cell	cell	NN
cord-023168-cd7adns8	1217	19	,	,	,
cord-023168-cd7adns8	1217	20	T	t	NN
cord-023168-cd7adns8	1217	21	-	-	HYPH
cord-023168-cd7adns8	1217	22	cell	cell	NN
cord-023168-cd7adns8	1217	23	and	and	CC
cord-023168-cd7adns8	1217	24	NK	nk	NN
cord-023168-cd7adns8	1217	25	-	-	HYPH
cord-023168-cd7adns8	1217	26	cell	cell	NN
cord-023168-cd7adns8	1217	27	,	,	,
cord-023168-cd7adns8	1217	28	and	and	CC
cord-023168-cd7adns8	1217	29	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1217	30	-	-	HYPH
cord-023168-cd7adns8	1217	31	associated	associate	VBN
cord-023168-cd7adns8	1217	32	types	type	NNS
cord-023168-cd7adns8	1217	33	.	.	.
cord-023168-cd7adns8	1218	1	The	the	DT
cord-023168-cd7adns8	1218	2	clinical	clinical	JJ
cord-023168-cd7adns8	1218	3	presentation	presentation	NN
cord-023168-cd7adns8	1218	4	of	of	IN
cord-023168-cd7adns8	1218	5	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1218	6	is	be	VBZ
cord-023168-cd7adns8	1218	7	characterized	characterize	VBN
cord-023168-cd7adns8	1218	8	by	by	IN
cord-023168-cd7adns8	1218	9	enlargement	enlargement	NN
cord-023168-cd7adns8	1218	10	of	of	IN
cord-023168-cd7adns8	1218	11	the	the	DT
cord-023168-cd7adns8	1218	12	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1218	13	organs	organ	NNS
cord-023168-cd7adns8	1218	14	and	and	CC
cord-023168-cd7adns8	1218	15	subsequent	subsequent	JJ
cord-023168-cd7adns8	1218	16	compression	compression	NN
cord-023168-cd7adns8	1218	17	of	of	IN
cord-023168-cd7adns8	1218	18	the	the	DT
cord-023168-cd7adns8	1218	19	adjacent	adjacent	JJ
cord-023168-cd7adns8	1218	20	structures	structure	NNS
cord-023168-cd7adns8	1218	21	,	,	,
cord-023168-cd7adns8	1218	22	infiltration	infiltration	NN
cord-023168-cd7adns8	1218	23	of	of	IN
cord-023168-cd7adns8	1218	24	organs	organ	NNS
cord-023168-cd7adns8	1218	25	by	by	IN
cord-023168-cd7adns8	1218	26	the	the	DT
cord-023168-cd7adns8	1218	27	malignant	malignant	JJ
cord-023168-cd7adns8	1218	28	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1218	29	cells	cell	NNS
cord-023168-cd7adns8	1218	30	and	and	CC
cord-023168-cd7adns8	1218	31	a	a	DT
cord-023168-cd7adns8	1218	32	dysfunctional	dysfunctional	JJ
cord-023168-cd7adns8	1218	33	immunological	immunological	JJ
cord-023168-cd7adns8	1218	34	system	system	NN
cord-023168-cd7adns8	1218	35	which	which	WDT
cord-023168-cd7adns8	1218	36	can	can	MD
cord-023168-cd7adns8	1218	37	manifest	manifest	VB
cord-023168-cd7adns8	1218	38	as	as	IN
cord-023168-cd7adns8	1218	39	immunosuppression	immunosuppression	NN
cord-023168-cd7adns8	1218	40	or	or	CC
cord-023168-cd7adns8	1218	41	excessive	excessive	JJ
cord-023168-cd7adns8	1218	42	but	but	CC
cord-023168-cd7adns8	1218	43	dysregulated	dysregulated	JJ
cord-023168-cd7adns8	1218	44	immune	immune	JJ
cord-023168-cd7adns8	1218	45	activation	activation	NN
cord-023168-cd7adns8	1218	46	associated	associate	VBN
cord-023168-cd7adns8	1218	47	with	with	IN
cord-023168-cd7adns8	1218	48	,	,	,
cord-023168-cd7adns8	1218	49	for	for	IN
cord-023168-cd7adns8	1218	50	example	example	NN
cord-023168-cd7adns8	1218	51	,	,	,
cord-023168-cd7adns8	1218	52	autoimmune	autoimmune	JJ
cord-023168-cd7adns8	1218	53	conditions	condition	NNS
cord-023168-cd7adns8	1218	54	.	.	.
cord-023168-cd7adns8	1219	1	The	the	DT
cord-023168-cd7adns8	1219	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1219	3	and	and	CC
cord-023168-cd7adns8	1219	4	management	management	NN
cord-023168-cd7adns8	1219	5	of	of	IN
cord-023168-cd7adns8	1219	6	the	the	DT
cord-023168-cd7adns8	1219	7	various	various	JJ
cord-023168-cd7adns8	1219	8	types	type	NNS
cord-023168-cd7adns8	1219	9	of	of	IN
cord-023168-cd7adns8	1219	10	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1219	11	are	be	VBP
cord-023168-cd7adns8	1219	12	complicated	complicated	JJ
cord-023168-cd7adns8	1219	13	and	and	CC
cord-023168-cd7adns8	1219	14	should	should	MD
cord-023168-cd7adns8	1219	15	be	be	VB
cord-023168-cd7adns8	1219	16	undertaken	undertake	VBN
cord-023168-cd7adns8	1219	17	in	in	IN
cord-023168-cd7adns8	1219	18	a	a	DT
cord-023168-cd7adns8	1219	19	specialist	specialist	NN
cord-023168-cd7adns8	1219	20	BOX	BOX	NNP
cord-023168-cd7adns8	1219	21	65	65	CD
cord-023168-cd7adns8	1219	22	.	.	.
cord-023168-cd7adns8	1220	1	22	22	CD
cord-023168-cd7adns8	1220	2	CLINICAL	clinical	NN
cord-023168-cd7adns8	1220	3	FEATURES	features	NN
cord-023168-cd7adns8	1220	4	OF	of	IN
cord-023168-cd7adns8	1220	5	LEUKAEMIAS	LEUKAEMIAS	NNP
cord-023168-cd7adns8	1220	6	•	•	NNP
cord-023168-cd7adns8	1220	7	Fatigue	Fatigue	NNP
cord-023168-cd7adns8	1220	8	and	and	CC
cord-023168-cd7adns8	1220	9	cardiac	cardiac	JJ
cord-023168-cd7adns8	1220	10	symptoms	symptom	NNS
cord-023168-cd7adns8	1220	11	from	from	IN
cord-023168-cd7adns8	1220	12	anaemia	anaemia	NN
cord-023168-cd7adns8	1221	1	•	•	NNP
cord-023168-cd7adns8	1222	1	Bleeding	bleed	VBG
cord-023168-cd7adns8	1222	2	from	from	IN
cord-023168-cd7adns8	1222	3	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1223	1	•	•	NNP
cord-023168-cd7adns8	1224	1	Increased	increase	VBN
cord-023168-cd7adns8	1224	2	risk	risk	NN
cord-023168-cd7adns8	1224	3	of	of	IN
cord-023168-cd7adns8	1224	4	infections	infection	NNS
cord-023168-cd7adns8	1224	5	despite	despite	IN
cord-023168-cd7adns8	1224	6	a	a	DT
cord-023168-cd7adns8	1224	7	higher	high	JJR
cord-023168-cd7adns8	1224	8	number	number	NN
cord-023168-cd7adns8	1224	9	but	but	CC
cord-023168-cd7adns8	1224	10	dysfunctional	dysfunctional	JJ
cord-023168-cd7adns8	1224	11	white	white	JJ
cord-023168-cd7adns8	1224	12	cells	cell	NNS
cord-023168-cd7adns8	1225	1	•	•	NNP
cord-023168-cd7adns8	1226	1	Lymphadenopathy	Lymphadenopathy	NNP
cord-023168-cd7adns8	1226	2	and	and	CC
cord-023168-cd7adns8	1226	3	hepatosplenomegaly	hepatosplenomegaly	NNP
cord-023168-cd7adns8	1226	4	occur	occur	VBP
cord-023168-cd7adns8	1226	5	with	with	IN
cord-023168-cd7adns8	1226	6	ALL	all	DT
cord-023168-cd7adns8	1226	7	although	although	IN
cord-023168-cd7adns8	1226	8	lymphadenopathy	lymphadenopathy	JJ
cord-023168-cd7adns8	1226	9	may	may	MD
cord-023168-cd7adns8	1226	10	be	be	VB
cord-023168-cd7adns8	1226	11	observed	observe	VBN
cord-023168-cd7adns8	1226	12	in	in	IN
cord-023168-cd7adns8	1226	13	the	the	DT
cord-023168-cd7adns8	1226	14	monocytic	monocytic	JJ
cord-023168-cd7adns8	1226	15	variety	variety	NN
cord-023168-cd7adns8	1226	16	of	of	IN
cord-023168-cd7adns8	1226	17	AML	AML	NNP
cord-023168-cd7adns8	1226	18	•	•	NNP
cord-023168-cd7adns8	1226	19	Blindness	Blindness	NNP
cord-023168-cd7adns8	1226	20	due	due	IN
cord-023168-cd7adns8	1226	21	to	to	IN
cord-023168-cd7adns8	1226	22	hyperviscosity	hyperviscosity	NN
cord-023168-cd7adns8	1226	23	from	from	IN
cord-023168-cd7adns8	1226	24	hyperleukocytosis	hyperleukocytosis	NNP
cord-023168-cd7adns8	1227	1	•	•	NNP
cord-023168-cd7adns8	1228	1	Tumour	tumour	NN
cord-023168-cd7adns8	1228	2	lysis	lysis	NN
cord-023168-cd7adns8	1228	3	syndrome	syndrome	NN
cord-023168-cd7adns8	1228	4	due	due	JJ
cord-023168-cd7adns8	1228	5	to	to	IN
cord-023168-cd7adns8	1228	6	spontaneous	spontaneous	JJ
cord-023168-cd7adns8	1228	7	cell	cell	NN
cord-023168-cd7adns8	1228	8	lysis	lysis	NN
cord-023168-cd7adns8	1228	9	presents	present	VBZ
cord-023168-cd7adns8	1228	10	as	as	IN
cord-023168-cd7adns8	1228	11	renal	renal	JJ
cord-023168-cd7adns8	1228	12	failure	failure	NN
cord-023168-cd7adns8	1228	13	•	•	NNP
cord-023168-cd7adns8	1229	1	Pustules	pustule	NNS
cord-023168-cd7adns8	1229	2	or	or	CC
cord-023168-cd7adns8	1229	3	pyogenic	pyogenic	JJ
cord-023168-cd7adns8	1229	4	infections	infection	NNS
cord-023168-cd7adns8	1229	5	of	of	IN
cord-023168-cd7adns8	1229	6	the	the	DT
cord-023168-cd7adns8	1229	7	skin	skin	NN
cord-023168-cd7adns8	1229	8	from	from	IN
cord-023168-cd7adns8	1229	9	minor	minor	JJ
cord-023168-cd7adns8	1229	10	wounds	wound	NNS
cord-023168-cd7adns8	1230	1	•	•	NNP
cord-023168-cd7adns8	1231	1	Bleeding	bleed	VBG
cord-023168-cd7adns8	1231	2	gums	gum	NNS
cord-023168-cd7adns8	1231	3	are	be	VBP
cord-023168-cd7adns8	1231	4	a	a	DT
cord-023168-cd7adns8	1231	5	characteristic	characteristic	JJ
cord-023168-cd7adns8	1231	6	feature	feature	NN
cord-023168-cd7adns8	1231	7	of	of	IN
cord-023168-cd7adns8	1231	8	acute	acute	JJ
cord-023168-cd7adns8	1231	9	monocytic	monocytic	JJ
cord-023168-cd7adns8	1231	10	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1232	1	•	•	NNP
cord-023168-cd7adns8	1233	1	Disseminated	disseminate	VBN
cord-023168-cd7adns8	1233	2	intravascular	intravascular	JJ
cord-023168-cd7adns8	1233	3	coagulation	coagulation	NN
cord-023168-cd7adns8	1233	4	can	can	MD
cord-023168-cd7adns8	1233	5	occur	occur	VB
cord-023168-cd7adns8	1233	6	with	with	IN
cord-023168-cd7adns8	1233	7	acute	acute	JJ
cord-023168-cd7adns8	1233	8	promyelocytic	promyelocytic	JJ
cord-023168-cd7adns8	1233	9	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1234	1	•	•	NNP
cord-023168-cd7adns8	1235	1	Gout	gout	NN
cord-023168-cd7adns8	1235	2	can	can	MD
cord-023168-cd7adns8	1235	3	arise	arise	VB
cord-023168-cd7adns8	1235	4	from	from	IN
cord-023168-cd7adns8	1235	5	breakdown	breakdown	NN
cord-023168-cd7adns8	1235	6	of	of	IN
cord-023168-cd7adns8	1235	7	the	the	DT
cord-023168-cd7adns8	1235	8	excess	excess	JJ
cord-023168-cd7adns8	1235	9	white	white	JJ
cord-023168-cd7adns8	1235	10	cells	cell	NNS
cord-023168-cd7adns8	1235	11	and	and	CC
cord-023168-cd7adns8	1235	12	release	release	NN
cord-023168-cd7adns8	1235	13	of	of	IN
cord-023168-cd7adns8	1235	14	uric	uric	NN
cord-023168-cd7adns8	1235	15	acid	acid	NN
cord-023168-cd7adns8	1236	1	•	•	NNP
cord-023168-cd7adns8	1237	1	Oral	oral	JJ
cord-023168-cd7adns8	1237	2	aphthous	aphthous	JJ
cord-023168-cd7adns8	1237	3	ulceration	ulceration	NN
cord-023168-cd7adns8	1237	4	is	be	VBZ
cord-023168-cd7adns8	1237	5	seen	see	VBN
cord-023168-cd7adns8	1237	6	with	with	IN
cord-023168-cd7adns8	1237	7	severe	severe	JJ
cord-023168-cd7adns8	1237	8	neutropenia	neutropenia	NN
cord-023168-cd7adns8	1237	9	in	in	IN
cord-023168-cd7adns8	1237	10	both	both	DT
cord-023168-cd7adns8	1237	11	AML	AML	NNP
cord-023168-cd7adns8	1237	12	and	and	CC
cord-023168-cd7adns8	1237	13	ALL	all	DT
cord-023168-cd7adns8	1238	1	•	•	NNP
cord-023168-cd7adns8	1239	1	Granulocytic	granulocytic	JJ
cord-023168-cd7adns8	1239	2	sarcoma	sarcoma	NN
cord-023168-cd7adns8	1239	3	or	or	CC
cord-023168-cd7adns8	1239	4	chloroma	chloroma	NNP
cord-023168-cd7adns8	1239	5	represent	represent	VBP
cord-023168-cd7adns8	1239	6	extramedullary	extramedullary	JJ
cord-023168-cd7adns8	1239	7	deposits	deposit	NNS
cord-023168-cd7adns8	1239	8	of	of	IN
cord-023168-cd7adns8	1239	9	leukaemic	leukaemic	JJ
cord-023168-cd7adns8	1239	10	cells	cell	NNS
cord-023168-cd7adns8	1239	11	in	in	IN
cord-023168-cd7adns8	1239	12	any	any	DT
cord-023168-cd7adns8	1239	13	organ	organ	NN
cord-023168-cd7adns8	1239	14	but	but	CC
cord-023168-cd7adns8	1239	15	mainly	mainly	RB
cord-023168-cd7adns8	1239	16	the	the	DT
cord-023168-cd7adns8	1239	17	skin	skin	NN
cord-023168-cd7adns8	1239	18	.	.	.
cord-023168-cd7adns8	1240	1	This	this	DT
cord-023168-cd7adns8	1240	2	may	may	MD
cord-023168-cd7adns8	1240	3	occur	occur	VB
cord-023168-cd7adns8	1240	4	in	in	IN
cord-023168-cd7adns8	1240	5	the	the	DT
cord-023168-cd7adns8	1240	6	absence	absence	NN
cord-023168-cd7adns8	1240	7	of	of	IN
cord-023168-cd7adns8	1240	8	peripheral	peripheral	JJ
cord-023168-cd7adns8	1240	9	blood	blood	NN
cord-023168-cd7adns8	1240	10	involvement	involvement	NN
cord-023168-cd7adns8	1240	11	and	and	CC
cord-023168-cd7adns8	1240	12	is	be	VBZ
cord-023168-cd7adns8	1240	13	more	more	RBR
cord-023168-cd7adns8	1240	14	common	common	JJ
cord-023168-cd7adns8	1240	15	with	with	IN
cord-023168-cd7adns8	1240	16	chromosomal	chromosomal	JJ
cord-023168-cd7adns8	1240	17	translocation	translocation	NN
cord-023168-cd7adns8	1240	18	(	(	-LRB-
cord-023168-cd7adns8	1240	19	8	8	CD
cord-023168-cd7adns8	1240	20	;	;	:
cord-023168-cd7adns8	1240	21	21	21	CD
cord-023168-cd7adns8	1240	22	)	)	-RRB-
cord-023168-cd7adns8	1240	23	of	of	IN
cord-023168-cd7adns8	1240	24	AML	AML	NNP
cord-023168-cd7adns8	1240	25	•	•	NNP
cord-023168-cd7adns8	1240	26	Central	central	JJ
cord-023168-cd7adns8	1240	27	nervous	nervous	JJ
cord-023168-cd7adns8	1240	28	system	system	NN
cord-023168-cd7adns8	1240	29	manifestations	manifestation	NNS
cord-023168-cd7adns8	1240	30	due	due	JJ
cord-023168-cd7adns8	1240	31	to	to	IN
cord-023168-cd7adns8	1240	32	sludging	sludge	VBG
cord-023168-cd7adns8	1240	33	of	of	IN
cord-023168-cd7adns8	1240	34	the	the	DT
cord-023168-cd7adns8	1240	35	cerebral	cerebral	JJ
cord-023168-cd7adns8	1240	36	circulation	circulation	NN
cord-023168-cd7adns8	1240	37	by	by	IN
cord-023168-cd7adns8	1240	38	the	the	DT
cord-023168-cd7adns8	1240	39	malignant	malignant	JJ
cord-023168-cd7adns8	1240	40	cells	cell	NNS
cord-023168-cd7adns8	1240	41	or	or	CC
cord-023168-cd7adns8	1240	42	increased	increase	VBN
cord-023168-cd7adns8	1240	43	intracranial	intracranial	JJ
cord-023168-cd7adns8	1240	44	pressure	pressure	NN
cord-023168-cd7adns8	1240	45	due	due	IN
cord-023168-cd7adns8	1240	46	to	to	IN
cord-023168-cd7adns8	1240	47	ventricular	ventricular	JJ
cord-023168-cd7adns8	1240	48	blockade	blockade	NN
cord-023168-cd7adns8	1240	49	can	can	MD
cord-023168-cd7adns8	1240	50	occur	occur	VB
cord-023168-cd7adns8	1240	51	.	.	.
cord-023168-cd7adns8	1241	1	Monocytic	monocytic	JJ
cord-023168-cd7adns8	1241	2	myeloid	myeloid	NN
cord-023168-cd7adns8	1241	3	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1241	4	can	can	MD
cord-023168-cd7adns8	1241	5	also	also	RB
cord-023168-cd7adns8	1241	6	involve	involve	VB
cord-023168-cd7adns8	1241	7	the	the	DT
cord-023168-cd7adns8	1241	8	meninges	meninge	NNS
cord-023168-cd7adns8	1241	9	•	•	NN
cord-023168-cd7adns8	1241	10	Intracranial	intracranial	JJ
cord-023168-cd7adns8	1241	11	haemorrhage	haemorrhage	NN
cord-023168-cd7adns8	1241	12	can	can	MD
cord-023168-cd7adns8	1241	13	occur	occur	VB
cord-023168-cd7adns8	1241	14	in	in	IN
cord-023168-cd7adns8	1241	15	ALL	all	DT
cord-023168-cd7adns8	1241	16	with	with	IN
cord-023168-cd7adns8	1241	17	very	very	RB
cord-023168-cd7adns8	1241	18	high	high	JJ
cord-023168-cd7adns8	1241	19	white	white	JJ
cord-023168-cd7adns8	1241	20	cell	cell	NN
cord-023168-cd7adns8	1241	21	counts	count	NNS
cord-023168-cd7adns8	1241	22	(	(	-LRB-
cord-023168-cd7adns8	1241	23	>	>	NFP
cord-023168-cd7adns8	1241	24	400	400	CD
cord-023168-cd7adns8	1241	25	×	×	NN
cord-023168-cd7adns8	1241	26	10	10	CD
cord-023168-cd7adns8	1241	27	9	9	CD
cord-023168-cd7adns8	1241	28	/L	/L	.
cord-023168-cd7adns8	1241	29	)	)	-RRB-
cord-023168-cd7adns8	1242	1	•	•	NNP
cord-023168-cd7adns8	1242	2	Bone	Bone	NNP
cord-023168-cd7adns8	1242	3	pain	pain	NN
cord-023168-cd7adns8	1242	4	and	and	CC
cord-023168-cd7adns8	1242	5	arthralgia	arthralgia	NN
cord-023168-cd7adns8	1242	6	can	can	MD
cord-023168-cd7adns8	1242	7	be	be	VB
cord-023168-cd7adns8	1242	8	a	a	DT
cord-023168-cd7adns8	1242	9	presenting	present	VBG
cord-023168-cd7adns8	1242	10	feature	feature	NN
cord-023168-cd7adns8	1242	11	of	of	IN
cord-023168-cd7adns8	1242	12	ALL	all	DT
cord-023168-cd7adns8	1242	13	in	in	IN
cord-023168-cd7adns8	1242	14	children	child	NNS
cord-023168-cd7adns8	1242	15	in	in	IN
cord-023168-cd7adns8	1242	16	more	more	JJR
cord-023168-cd7adns8	1242	17	than	than	IN
cord-023168-cd7adns8	1242	18	a	a	DT
cord-023168-cd7adns8	1242	19	quarter	quarter	NN
cord-023168-cd7adns8	1242	20	.	.	.
cord-023168-cd7adns8	1243	1	These	these	DT
cord-023168-cd7adns8	1243	2	children	child	NNS
cord-023168-cd7adns8	1243	3	may	may	MD
cord-023168-cd7adns8	1243	4	present	present	VB
cord-023168-cd7adns8	1243	5	with	with	IN
cord-023168-cd7adns8	1243	6	a	a	DT
cord-023168-cd7adns8	1243	7	limp	limp	JJ
cord-023168-cd7adns8	1243	8	or	or	CC
cord-023168-cd7adns8	1243	9	unwillingness	unwillingness	NN
cord-023168-cd7adns8	1243	10	to	to	TO
cord-023168-cd7adns8	1243	11	walk	walk	VB
cord-023168-cd7adns8	1243	12	due	due	IN
cord-023168-cd7adns8	1243	13	to	to	IN
cord-023168-cd7adns8	1243	14	marrow	marrow	NN
cord-023168-cd7adns8	1243	15	infiltration	infiltration	NN
cord-023168-cd7adns8	1243	16	by	by	IN
cord-023168-cd7adns8	1243	17	leukaemic	leukaemic	JJ
cord-023168-cd7adns8	1243	18	cells	cell	NNS
cord-023168-cd7adns8	1243	19	.	.	.
cord-023168-cd7adns8	1244	1	Rarely	rarely	RB
cord-023168-cd7adns8	1244	2	,	,	,
cord-023168-cd7adns8	1244	3	they	-PRON-	PRP
cord-023168-cd7adns8	1244	4	may	may	MD
cord-023168-cd7adns8	1244	5	have	have	VB
cord-023168-cd7adns8	1244	6	normal	normal	JJ
cord-023168-cd7adns8	1244	7	blood	blood	NN
cord-023168-cd7adns8	1244	8	counts	count	NNS
cord-023168-cd7adns8	1244	9	delaying	delay	VBG
cord-023168-cd7adns8	1244	10	the	the	DT
cord-023168-cd7adns8	1244	11	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1244	12	of	of	IN
cord-023168-cd7adns8	1244	13	ALL	all	DT
cord-023168-cd7adns8	1244	14	•	•	NNP
cord-023168-cd7adns8	1244	15	Anterior	Anterior	NNP
cord-023168-cd7adns8	1244	16	mediastinal	mediastinal	JJ
cord-023168-cd7adns8	1244	17	mass	mass	NN
cord-023168-cd7adns8	1244	18	(	(	-LRB-
cord-023168-cd7adns8	1244	19	thymus	thymus	NN
cord-023168-cd7adns8	1244	20	enlargement	enlargement	NN
cord-023168-cd7adns8	1244	21	)	)	-RRB-
cord-023168-cd7adns8	1244	22	can	can	MD
cord-023168-cd7adns8	1244	23	also	also	RB
cord-023168-cd7adns8	1244	24	occur	occur	VB
cord-023168-cd7adns8	1244	25	in	in	IN
cord-023168-cd7adns8	1244	26	children	child	NNS
cord-023168-cd7adns8	1244	27	and	and	CC
cord-023168-cd7adns8	1244	28	young	young	JJ
cord-023168-cd7adns8	1244	29	adults	adult	NNS
cord-023168-cd7adns8	1244	30	with	with	IN
cord-023168-cd7adns8	1244	31	ALL	all	DT
cord-023168-cd7adns8	1244	32	which	which	WDT
cord-023168-cd7adns8	1244	33	may	may	MD
cord-023168-cd7adns8	1244	34	present	present	VB
cord-023168-cd7adns8	1244	35	as	as	IN
cord-023168-cd7adns8	1244	36	superior	superior	JJ
cord-023168-cd7adns8	1244	37	venocaval	venocaval	NNP
cord-023168-cd7adns8	1244	38	obstruction	obstruction	NN
cord-023168-cd7adns8	1244	39	•	•	NNP
cord-023168-cd7adns8	1245	1	Painless	painless	JJ
cord-023168-cd7adns8	1245	2	enlargement	enlargement	NN
cord-023168-cd7adns8	1245	3	of	of	IN
cord-023168-cd7adns8	1245	4	scrotum	scrotum	NN
cord-023168-cd7adns8	1245	5	is	be	VBZ
cord-023168-cd7adns8	1245	6	a	a	DT
cord-023168-cd7adns8	1245	7	sign	sign	NN
cord-023168-cd7adns8	1245	8	of	of	IN
cord-023168-cd7adns8	1245	9	testicular	testicular	JJ
cord-023168-cd7adns8	1245	10	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1245	11	or	or	CC
cord-023168-cd7adns8	1245	12	hydrocele	hydrocele	NN
cord-023168-cd7adns8	1245	13	from	from	IN
cord-023168-cd7adns8	1245	14	lymphatic	lymphatic	JJ
cord-023168-cd7adns8	1245	15	obstruction	obstruction	NN
cord-023168-cd7adns8	1245	16	.	.	.
cord-023168-cd7adns8	1246	1	Priapism	priapism	NN
cord-023168-cd7adns8	1246	2	can	can	MD
cord-023168-cd7adns8	1246	3	result	result	VB
cord-023168-cd7adns8	1246	4	from	from	IN
cord-023168-cd7adns8	1246	5	hyperleukocytosis	hyperleukocytosis	NNP
cord-023168-cd7adns8	1246	6	rarely	rarely	RB
cord-023168-cd7adns8	1246	7	.	.	.
cord-023168-cd7adns8	1247	1	•	•	NNP
cord-023168-cd7adns8	1247	2	Most	most	RBS
cord-023168-cd7adns8	1247	3	often	often	RB
cord-023168-cd7adns8	1247	4	asymptomatic	asymptomatic	JJ
cord-023168-cd7adns8	1247	5	and	and	CC
cord-023168-cd7adns8	1247	6	usually	usually	RB
cord-023168-cd7adns8	1247	7	suspected	suspect	VBN
cord-023168-cd7adns8	1247	8	on	on	IN
cord-023168-cd7adns8	1247	9	blood	blood	NN
cord-023168-cd7adns8	1247	10	counts	count	NNS
cord-023168-cd7adns8	1248	1	•	•	NNP
cord-023168-cd7adns8	1249	1	The	the	DT
cord-023168-cd7adns8	1249	2	chronicity	chronicity	NN
cord-023168-cd7adns8	1249	3	of	of	IN
cord-023168-cd7adns8	1249	4	CML	CML	NNP
cord-023168-cd7adns8	1249	5	or	or	CC
cord-023168-cd7adns8	1249	6	CLL	CLL	NNP
cord-023168-cd7adns8	1249	7	tends	tend	VBZ
cord-023168-cd7adns8	1249	8	to	to	TO
cord-023168-cd7adns8	1249	9	cause	cause	VB
cord-023168-cd7adns8	1249	10	gradual	gradual	JJ
cord-023168-cd7adns8	1249	11	-	-	HYPH
cord-023168-cd7adns8	1249	12	onset	onset	NN
cord-023168-cd7adns8	1249	13	symptoms	symptom	NNS
cord-023168-cd7adns8	1249	14	since	since	IN
cord-023168-cd7adns8	1249	15	the	the	DT
cord-023168-cd7adns8	1249	16	patients	patient	NNS
cord-023168-cd7adns8	1249	17	get	get	VBP
cord-023168-cd7adns8	1249	18	adjusted	adjust	VBN
cord-023168-cd7adns8	1249	19	to	to	IN
cord-023168-cd7adns8	1249	20	the	the	DT
cord-023168-cd7adns8	1249	21	slowly	slowly	RB
cord-023168-cd7adns8	1249	22	developing	develop	VBG
cord-023168-cd7adns8	1249	23	anaemia	anaemia	NN
cord-023168-cd7adns8	1249	24	•	•	.
cord-023168-cd7adns8	1249	25	Abdominal	abdominal	JJ
cord-023168-cd7adns8	1249	26	discomfort	discomfort	NN
cord-023168-cd7adns8	1249	27	and	and	CC
cord-023168-cd7adns8	1249	28	early	early	JJ
cord-023168-cd7adns8	1249	29	satiety	satiety	NN
cord-023168-cd7adns8	1249	30	are	be	VBP
cord-023168-cd7adns8	1249	31	a	a	DT
cord-023168-cd7adns8	1249	32	feature	feature	NN
cord-023168-cd7adns8	1249	33	of	of	IN
cord-023168-cd7adns8	1249	34	CML	CML	NNP
cord-023168-cd7adns8	1249	35	due	due	IN
cord-023168-cd7adns8	1249	36	to	to	IN
cord-023168-cd7adns8	1249	37	excessive	excessive	JJ
cord-023168-cd7adns8	1249	38	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	1249	39	compressing	compress	VBG
cord-023168-cd7adns8	1249	40	the	the	DT
cord-023168-cd7adns8	1249	41	stomach	stomach	NN
cord-023168-cd7adns8	1249	42	and	and	CC
cord-023168-cd7adns8	1249	43	reducing	reduce	VBG
cord-023168-cd7adns8	1249	44	the	the	DT
cord-023168-cd7adns8	1249	45	luminal	luminal	JJ
cord-023168-cd7adns8	1249	46	volume	volume	NN
cord-023168-cd7adns8	1250	1	•	•	NNP
cord-023168-cd7adns8	1251	1	Sternal	sternal	JJ
cord-023168-cd7adns8	1251	2	tenderness	tenderness	NN
cord-023168-cd7adns8	1251	3	may	may	MD
cord-023168-cd7adns8	1251	4	be	be	VB
cord-023168-cd7adns8	1251	5	noted	note	VBN
cord-023168-cd7adns8	1251	6	in	in	IN
cord-023168-cd7adns8	1251	7	CML	CML	NNP
cord-023168-cd7adns8	1252	1	•	•	NNP
cord-023168-cd7adns8	1253	1	Hyperleukocytosis	Hyperleukocytosis	NNP
cord-023168-cd7adns8	1253	2	in	in	IN
cord-023168-cd7adns8	1253	3	CML	CML	NNP
cord-023168-cd7adns8	1253	4	can	can	MD
cord-023168-cd7adns8	1253	5	occur	occur	VB
cord-023168-cd7adns8	1253	6	more	more	RBR
cord-023168-cd7adns8	1253	7	often	often	RB
cord-023168-cd7adns8	1253	8	than	than	IN
cord-023168-cd7adns8	1253	9	with	with	IN
cord-023168-cd7adns8	1253	10	AML	AML	NNP
cord-023168-cd7adns8	1253	11	or	or	CC
cord-023168-cd7adns8	1253	12	ALL	all	DT
cord-023168-cd7adns8	1253	13	due	due	IN
cord-023168-cd7adns8	1253	14	to	to	IN
cord-023168-cd7adns8	1253	15	the	the	DT
cord-023168-cd7adns8	1253	16	gradual	gradual	JJ
cord-023168-cd7adns8	1253	17	increase	increase	NN
cord-023168-cd7adns8	1253	18	in	in	IN
cord-023168-cd7adns8	1253	19	white	white	JJ
cord-023168-cd7adns8	1253	20	cells	cell	NNS
cord-023168-cd7adns8	1253	21	.	.	.
cord-023168-cd7adns8	1254	1	This	this	DT
cord-023168-cd7adns8	1254	2	can	can	MD
cord-023168-cd7adns8	1254	3	cause	cause	VB
cord-023168-cd7adns8	1254	4	symptoms	symptom	NNS
cord-023168-cd7adns8	1254	5	like	like	IN
cord-023168-cd7adns8	1254	6	hyperuricaemia	hyperuricaemia	NN
cord-023168-cd7adns8	1254	7	and	and	CC
cord-023168-cd7adns8	1254	8	gout	gout	NN
cord-023168-cd7adns8	1254	9	,	,	,
cord-023168-cd7adns8	1254	10	tinnitus	tinnitus	NN
cord-023168-cd7adns8	1254	11	,	,	,
cord-023168-cd7adns8	1254	12	priapism	priapism	NN
cord-023168-cd7adns8	1254	13	or	or	CC
cord-023168-cd7adns8	1254	14	central	central	JJ
cord-023168-cd7adns8	1254	15	nervous	nervous	JJ
cord-023168-cd7adns8	1254	16	system	system	NN
cord-023168-cd7adns8	1254	17	disturbances	disturbance	NNS
cord-023168-cd7adns8	1255	1	•	•	NNP
cord-023168-cd7adns8	1256	1	Left	leave	VBN
cord-023168-cd7adns8	1256	2	shoulder	shoulder	NN
cord-023168-cd7adns8	1256	3	tip	tip	NN
cord-023168-cd7adns8	1256	4	pain	pain	NN
cord-023168-cd7adns8	1256	5	can	can	MD
cord-023168-cd7adns8	1256	6	arise	arise	VB
cord-023168-cd7adns8	1256	7	from	from	IN
cord-023168-cd7adns8	1256	8	splenic	splenic	JJ
cord-023168-cd7adns8	1256	9	infarction	infarction	NN
cord-023168-cd7adns8	1256	10	from	from	IN
cord-023168-cd7adns8	1256	11	the	the	DT
cord-023168-cd7adns8	1256	12	massive	massive	JJ
cord-023168-cd7adns8	1256	13	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	1256	14	in	in	IN
cord-023168-cd7adns8	1256	15	CML	CML	NNP
cord-023168-cd7adns8	1257	1	•	•	NNP
cord-023168-cd7adns8	1257	2	CML	CML	NNP
cord-023168-cd7adns8	1257	3	can	can	MD
cord-023168-cd7adns8	1257	4	rarely	rarely	RB
cord-023168-cd7adns8	1257	5	present	present	VB
cord-023168-cd7adns8	1257	6	with	with	IN
cord-023168-cd7adns8	1257	7	features	feature	NNS
cord-023168-cd7adns8	1257	8	of	of	IN
cord-023168-cd7adns8	1257	9	thyrotoxicosis	thyrotoxicosis	NN
cord-023168-cd7adns8	1257	10	(	(	-LRB-
cord-023168-cd7adns8	1257	11	heat	heat	NN
cord-023168-cd7adns8	1257	12	intolerance	intolerance	NN
cord-023168-cd7adns8	1257	13	,	,	,
cord-023168-cd7adns8	1257	14	weight	weight	NN
cord-023168-cd7adns8	1257	15	loss	loss	NN
cord-023168-cd7adns8	1257	16	and	and	CC
cord-023168-cd7adns8	1257	17	excessive	excessive	JJ
cord-023168-cd7adns8	1257	18	sweating	sweating	NN
cord-023168-cd7adns8	1257	19	)	)	-RRB-
cord-023168-cd7adns8	1257	20	due	due	IN
cord-023168-cd7adns8	1257	21	to	to	IN
cord-023168-cd7adns8	1257	22	hyper	hyper	JJ
cord-023168-cd7adns8	1257	23	-	-	NN
cord-023168-cd7adns8	1257	24	metabolism	metabolism	JJ
cord-023168-cd7adns8	1258	1	•	•	NNP
cord-023168-cd7adns8	1259	1	CLL	CLL	NNP
cord-023168-cd7adns8	1259	2	is	be	VBZ
cord-023168-cd7adns8	1259	3	often	often	RB
cord-023168-cd7adns8	1259	4	associated	associate	VBN
cord-023168-cd7adns8	1259	5	with	with	IN
cord-023168-cd7adns8	1259	6	lymphadenopathy	lymphadenopathy	NN
cord-023168-cd7adns8	1259	7	and	and	CC
cord-023168-cd7adns8	1259	8	rarely	rarely	RB
cord-023168-cd7adns8	1259	9	with	with	IN
cord-023168-cd7adns8	1259	10	mild	mild	JJ
cord-023168-cd7adns8	1259	11	to	to	IN
cord-023168-cd7adns8	1259	12	moderate	moderate	JJ
cord-023168-cd7adns8	1259	13	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	1259	14	.	.	.
cord-023168-cd7adns8	1260	1	ALL	all	DT
cord-023168-cd7adns8	1260	2	,	,	,
cord-023168-cd7adns8	1260	3	acute	acute	JJ
cord-023168-cd7adns8	1260	4	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1260	5	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1260	6	;	;	:
cord-023168-cd7adns8	1260	7	AML	AML	NNP
cord-023168-cd7adns8	1260	8	,	,	,
cord-023168-cd7adns8	1260	9	acute	acute	JJ
cord-023168-cd7adns8	1260	10	myeloid	myeloid	NN
cord-023168-cd7adns8	1260	11	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1260	12	;	;	:
cord-023168-cd7adns8	1260	13	CLL	CLL	NNP
cord-023168-cd7adns8	1260	14	,	,	,
cord-023168-cd7adns8	1260	15	chronic	chronic	JJ
cord-023168-cd7adns8	1260	16	lymphocytic	lymphocytic	JJ
cord-023168-cd7adns8	1260	17	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1260	18	;	;	:
cord-023168-cd7adns8	1260	19	CML	CML	NNP
cord-023168-cd7adns8	1260	20	,	,	,
cord-023168-cd7adns8	1260	21	chronic	chronic	JJ
cord-023168-cd7adns8	1260	22	myeloid	myeloid	NN
cord-023168-cd7adns8	1260	23	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1260	24	.	.	.
cord-023168-cd7adns8	1261	1	centre	centre	NNP
cord-023168-cd7adns8	1261	2	.	.	.
cord-023168-cd7adns8	1262	1	Diagnosis	diagnosis	NN
cord-023168-cd7adns8	1262	2	depends	depend	VBZ
cord-023168-cd7adns8	1262	3	on	on	IN
cord-023168-cd7adns8	1262	4	clinical	clinical	JJ
cord-023168-cd7adns8	1262	5	history	history	NN
cord-023168-cd7adns8	1262	6	and	and	CC
cord-023168-cd7adns8	1262	7	examination	examination	NN
cord-023168-cd7adns8	1262	8	,	,	,
cord-023168-cd7adns8	1262	9	radiological	radiological	JJ
cord-023168-cd7adns8	1262	10	investigations	investigation	NNS
cord-023168-cd7adns8	1262	11	to	to	TO
cord-023168-cd7adns8	1262	12	document	document	VB
cord-023168-cd7adns8	1262	13	the	the	DT
cord-023168-cd7adns8	1262	14	extent	extent	NN
cord-023168-cd7adns8	1262	15	of	of	IN
cord-023168-cd7adns8	1262	16	disease	disease	NN
cord-023168-cd7adns8	1262	17	,	,	,
cord-023168-cd7adns8	1262	18	and	and	CC
cord-023168-cd7adns8	1262	19	morphology	morphology	NN
cord-023168-cd7adns8	1262	20	,	,	,
cord-023168-cd7adns8	1262	21	immunohistochemistry	immunohistochemistry	NN
cord-023168-cd7adns8	1262	22	and	and	CC
cord-023168-cd7adns8	1262	23	molecular	molecular	JJ
cord-023168-cd7adns8	1262	24	studies	study	NNS
cord-023168-cd7adns8	1262	25	on	on	IN
cord-023168-cd7adns8	1262	26	tissue	tissue	NN
cord-023168-cd7adns8	1262	27	samples	sample	NNS
cord-023168-cd7adns8	1262	28	to	to	TO
cord-023168-cd7adns8	1262	29	confirm	confirm	VB
cord-023168-cd7adns8	1262	30	the	the	DT
cord-023168-cd7adns8	1262	31	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1262	32	subtype	subtype	NN
cord-023168-cd7adns8	1262	33	.	.	.
cord-023168-cd7adns8	1263	1	Guidance	guidance	NN
cord-023168-cd7adns8	1263	2	on	on	IN
cord-023168-cd7adns8	1263	3	the	the	DT
cord-023168-cd7adns8	1263	4	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1263	5	and	and	CC
cord-023168-cd7adns8	1263	6	treatment	treatment	NN
cord-023168-cd7adns8	1263	7	of	of	IN
cord-023168-cd7adns8	1263	8	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1263	9	in	in	IN
cord-023168-cd7adns8	1263	10	settings	setting	NNS
cord-023168-cd7adns8	1263	11	where	where	WRB
cord-023168-cd7adns8	1263	12	resources	resource	NNS
cord-023168-cd7adns8	1263	13	are	be	VBP
cord-023168-cd7adns8	1263	14	limited	limit	VBN
cord-023168-cd7adns8	1263	15	includes	include	VBZ
cord-023168-cd7adns8	1263	16	recommendations	recommendation	NNS
cord-023168-cd7adns8	1263	17	about	about	IN
cord-023168-cd7adns8	1263	18	panels	panel	NNS
cord-023168-cd7adns8	1263	19	of	of	IN
cord-023168-cd7adns8	1263	20	immunostains	immunostain	NNS
cord-023168-cd7adns8	1263	21	and	and	CC
cord-023168-cd7adns8	1263	22	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1263	23	regimens	regimen	NNS
cord-023168-cd7adns8	1263	24	that	that	WDT
cord-023168-cd7adns8	1263	25	minimize	minimize	VBP
cord-023168-cd7adns8	1263	26	the	the	DT
cord-023168-cd7adns8	1263	27	need	need	NN
cord-023168-cd7adns8	1263	28	for	for	IN
cord-023168-cd7adns8	1263	29	supportive	supportive	JJ
cord-023168-cd7adns8	1263	30	care	care	NN
cord-023168-cd7adns8	1263	31	.	.	.
cord-023168-cd7adns8	1264	1	322	322	CD
cord-023168-cd7adns8	1264	2	Tele	Tele	NNP
cord-023168-cd7adns8	1264	3	-	-	HYPH
cord-023168-cd7adns8	1264	4	pathology	pathology	NN
cord-023168-cd7adns8	1264	5	,	,	,
cord-023168-cd7adns8	1264	6	which	which	WDT
cord-023168-cd7adns8	1264	7	involves	involve	VBZ
cord-023168-cd7adns8	1264	8	transmitting	transmit	VBG
cord-023168-cd7adns8	1264	9	histological	histological	JJ
cord-023168-cd7adns8	1264	10	images	image	NNS
cord-023168-cd7adns8	1264	11	via	via	IN
cord-023168-cd7adns8	1264	12	the	the	DT
cord-023168-cd7adns8	1264	13	internet	internet	NN
cord-023168-cd7adns8	1264	14	to	to	IN
cord-023168-cd7adns8	1264	15	experts	expert	NNS
cord-023168-cd7adns8	1264	16	overseas	overseas	RB
cord-023168-cd7adns8	1264	17	,	,	,
cord-023168-cd7adns8	1264	18	may	may	MD
cord-023168-cd7adns8	1264	19	be	be	VB
cord-023168-cd7adns8	1264	20	helpful	helpful	JJ
cord-023168-cd7adns8	1264	21	in	in	IN
cord-023168-cd7adns8	1264	22	certain	certain	JJ
cord-023168-cd7adns8	1264	23	circumstances	circumstance	NNS
cord-023168-cd7adns8	1264	24	though	though	IN
cord-023168-cd7adns8	1264	25	it	-PRON-	PRP
cord-023168-cd7adns8	1264	26	is	be	VBZ
cord-023168-cd7adns8	1264	27	dependent	dependent	JJ
cord-023168-cd7adns8	1264	28	on	on	IN
cord-023168-cd7adns8	1264	29	the	the	DT
cord-023168-cd7adns8	1264	30	quality	quality	NN
cord-023168-cd7adns8	1264	31	of	of	IN
cord-023168-cd7adns8	1264	32	the	the	DT
cord-023168-cd7adns8	1264	33	histology	histology	NN
cord-023168-cd7adns8	1264	34	preparations	preparation	NNS
cord-023168-cd7adns8	1264	35	and	and	CC
cord-023168-cd7adns8	1264	36	the	the	DT
cord-023168-cd7adns8	1264	37	images	image	NNS
cord-023168-cd7adns8	1264	38	of	of	IN
cord-023168-cd7adns8	1264	39	appropriate	appropriate	JJ
cord-023168-cd7adns8	1264	40	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	1264	41	regions	region	NNS
cord-023168-cd7adns8	1264	42	in	in	IN
cord-023168-cd7adns8	1264	43	the	the	DT
cord-023168-cd7adns8	1264	44	sample	sample	NN
cord-023168-cd7adns8	1264	45	.	.	.
cord-023168-cd7adns8	1265	1	Treatment	treatment	NN
cord-023168-cd7adns8	1265	2	regimens	regimen	NNS
cord-023168-cd7adns8	1265	3	for	for	IN
cord-023168-cd7adns8	1265	4	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1265	5	differ	differ	VBP
cord-023168-cd7adns8	1265	6	according	accord	VBG
cord-023168-cd7adns8	1265	7	to	to	IN
cord-023168-cd7adns8	1265	8	the	the	DT
cord-023168-cd7adns8	1265	9	subtype	subtype	NN
cord-023168-cd7adns8	1265	10	but	but	CC
cord-023168-cd7adns8	1265	11	may	may	MD
cord-023168-cd7adns8	1265	12	involve	involve	VB
cord-023168-cd7adns8	1265	13	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1265	14	and	and	CC
cord-023168-cd7adns8	1265	15	radiotherapy	radiotherapy	NN
cord-023168-cd7adns8	1265	16	.	.	.
cord-023168-cd7adns8	1266	1	High	high	JJ
cord-023168-cd7adns8	1266	2	remission	remission	NN
cord-023168-cd7adns8	1266	3	rates	rate	NNS
cord-023168-cd7adns8	1266	4	can	can	MD
cord-023168-cd7adns8	1266	5	be	be	VB
cord-023168-cd7adns8	1266	6	achieved	achieve	VBN
cord-023168-cd7adns8	1266	7	in	in	IN
cord-023168-cd7adns8	1266	8	Burkitt	Burkitt	NNP
cord-023168-cd7adns8	1266	9	's	's	POS
cord-023168-cd7adns8	1266	10	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1266	11	with	with	IN
cord-023168-cd7adns8	1266	12	a	a	DT
cord-023168-cd7adns8	1266	13	combination	combination	NN
cord-023168-cd7adns8	1266	14	of	of	IN
cord-023168-cd7adns8	1266	15	cyclophosphamide	cyclophosphamide	NN
cord-023168-cd7adns8	1266	16	,	,	,
cord-023168-cd7adns8	1266	17	vincristine	vincristine	NN
cord-023168-cd7adns8	1266	18	and	and	CC
cord-023168-cd7adns8	1266	19	methotrexate	methotrexate	NNP
cord-023168-cd7adns8	1266	20	and	and	CC
cord-023168-cd7adns8	1266	21	progressive	progressive	JJ
cord-023168-cd7adns8	1266	22	disease	disease	NN
cord-023168-cd7adns8	1266	23	can	can	MD
cord-023168-cd7adns8	1266	24	be	be	VB
cord-023168-cd7adns8	1266	25	managed	manage	VBN
cord-023168-cd7adns8	1266	26	with	with	IN
cord-023168-cd7adns8	1266	27	ifosfamide	ifosfamide	NNP
cord-023168-cd7adns8	1266	28	,	,	,
cord-023168-cd7adns8	1266	29	mesna	mesna	NNS
cord-023168-cd7adns8	1266	30	and	and	CC
cord-023168-cd7adns8	1266	31	cytosine	cytosine	NN
cord-023168-cd7adns8	1266	32	arabinoside	arabinoside	NN
cord-023168-cd7adns8	1266	33	.	.	.
cord-023168-cd7adns8	1267	1	322	322	CD
cord-023168-cd7adns8	1267	2	,	,	,
cord-023168-cd7adns8	1267	3	323	323	CD
cord-023168-cd7adns8	1267	4	ADULT	ADULT	NNP
cord-023168-cd7adns8	1267	5	T	T	NNP
cord-023168-cd7adns8	1267	6	-	-	HYPH
cord-023168-cd7adns8	1267	7	CELL	CELL	NNP
cord-023168-cd7adns8	1267	8	LEUKAEMIA	LEUKAEMIA	NNP
cord-023168-cd7adns8	1267	9	-	-	HYPH
cord-023168-cd7adns8	1267	10	LYMPHOMA	LYMPHOMA	NNP
cord-023168-cd7adns8	1267	11	(	(	-LRB-
cord-023168-cd7adns8	1267	12	ATLL	ATLL	NNP
cord-023168-cd7adns8	1267	13	)	)	-RRB-
cord-023168-cd7adns8	1268	1	Adult	Adult	NNP
cord-023168-cd7adns8	1268	2	T	t	NN
cord-023168-cd7adns8	1268	3	-	-	HYPH
cord-023168-cd7adns8	1268	4	cell	cell	NN
cord-023168-cd7adns8	1268	5	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1268	6	-	-	HYPH
cord-023168-cd7adns8	1268	7	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1268	8	(	(	-LRB-
cord-023168-cd7adns8	1268	9	ATLL	ATLL	NNP
cord-023168-cd7adns8	1268	10	)	)	-RRB-
cord-023168-cd7adns8	1268	11	is	be	VBZ
cord-023168-cd7adns8	1268	12	an	an	DT
cord-023168-cd7adns8	1268	13	uncommon	uncommon	JJ
cord-023168-cd7adns8	1268	14	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1268	15	malignancy	malignancy	NN
cord-023168-cd7adns8	1268	16	which	which	WDT
cord-023168-cd7adns8	1268	17	occurs	occur	VBZ
cord-023168-cd7adns8	1268	18	in	in	IN
cord-023168-cd7adns8	1268	19	patients	patient	NNS
cord-023168-cd7adns8	1268	20	infected	infect	VBN
cord-023168-cd7adns8	1268	21	with	with	IN
cord-023168-cd7adns8	1268	22	human	human	JJ
cord-023168-cd7adns8	1268	23	T	T	NNP
cord-023168-cd7adns8	1268	24	-	-	HYPH
cord-023168-cd7adns8	1268	25	lymphotropic	lymphotropic	NNP
cord-023168-cd7adns8	1268	26	virus	virus	NN
cord-023168-cd7adns8	1268	27	type	type	NN
cord-023168-cd7adns8	1268	28	I	-PRON-	PRP
cord-023168-cd7adns8	1268	29	(	(	-LRB-
cord-023168-cd7adns8	1268	30	HTLV	HTLV	NNP
cord-023168-cd7adns8	1268	31	-	-	HYPH
cord-023168-cd7adns8	1268	32	I	I	NNP
cord-023168-cd7adns8	1268	33	)	)	-RRB-
cord-023168-cd7adns8	1268	34	.	.	.
cord-023168-cd7adns8	1269	1	324	324	CD
cord-023168-cd7adns8	1269	2	HTLV-1	HTLV-1	NNP
cord-023168-cd7adns8	1269	3	is	be	VBZ
cord-023168-cd7adns8	1269	4	endemic	endemic	JJ
cord-023168-cd7adns8	1269	5	in	in	IN
cord-023168-cd7adns8	1269	6	the	the	DT
cord-023168-cd7adns8	1269	7	Caribbean	caribbean	JJ
cord-023168-cd7adns8	1269	8	,	,	,
cord-023168-cd7adns8	1269	9	western	western	JJ
cord-023168-cd7adns8	1269	10	Africa	Africa	NNP
cord-023168-cd7adns8	1269	11	,	,	,
cord-023168-cd7adns8	1269	12	Peru	Peru	NNP
cord-023168-cd7adns8	1269	13	and	and	CC
cord-023168-cd7adns8	1269	14	southern	southern	JJ
cord-023168-cd7adns8	1269	15	Japan	Japan	NNP
cord-023168-cd7adns8	1269	16	.	.	.
cord-023168-cd7adns8	1270	1	Less	Less	JJR
cord-023168-cd7adns8	1270	2	than	than	IN
cord-023168-cd7adns8	1270	3	5	5	CD
cord-023168-cd7adns8	1270	4	%	%	NN
cord-023168-cd7adns8	1270	5	of	of	IN
cord-023168-cd7adns8	1270	6	those	those	DT
cord-023168-cd7adns8	1270	7	infected	infect	VBN
cord-023168-cd7adns8	1270	8	with	with	IN
cord-023168-cd7adns8	1270	9	HTLV	HTLV	NNP
cord-023168-cd7adns8	1271	1	-I	-i	WDT
cord-023168-cd7adns8	1271	2	develop	develop	VBP
cord-023168-cd7adns8	1271	3	ATLL	ATLL	NNP
cord-023168-cd7adns8	1271	4	and	and	CC
cord-023168-cd7adns8	1271	5	up	up	IN
cord-023168-cd7adns8	1271	6	to	to	TO
cord-023168-cd7adns8	1271	7	30	30	CD
cord-023168-cd7adns8	1271	8	years	year	NNS
cord-023168-cd7adns8	1271	9	can	can	MD
cord-023168-cd7adns8	1271	10	elapse	elapse	VB
cord-023168-cd7adns8	1271	11	between	between	IN
cord-023168-cd7adns8	1271	12	the	the	DT
cord-023168-cd7adns8	1271	13	primary	primary	JJ
cord-023168-cd7adns8	1271	14	infection	infection	NN
cord-023168-cd7adns8	1271	15	and	and	CC
cord-023168-cd7adns8	1271	16	the	the	DT
cord-023168-cd7adns8	1271	17	development	development	NN
cord-023168-cd7adns8	1271	18	of	of	IN
cord-023168-cd7adns8	1271	19	ATLL	ATLL	NNP
cord-023168-cd7adns8	1271	20	suggesting	suggest	VBG
cord-023168-cd7adns8	1271	21	additional	additional	JJ
cord-023168-cd7adns8	1271	22	factors	factor	NNS
cord-023168-cd7adns8	1271	23	are	be	VBP
cord-023168-cd7adns8	1271	24	needed	need	VBN
cord-023168-cd7adns8	1271	25	for	for	IN
cord-023168-cd7adns8	1271	26	malignant	malignant	JJ
cord-023168-cd7adns8	1271	27	transformation	transformation	NN
cord-023168-cd7adns8	1271	28	.	.	.
cord-023168-cd7adns8	1272	1	325	325	CD
cord-023168-cd7adns8	1272	2	ATLL	ATLL	NNP
cord-023168-cd7adns8	1272	3	presents	present	VBZ
cord-023168-cd7adns8	1272	4	acutely	acutely	RB
cord-023168-cd7adns8	1272	5	in	in	IN
cord-023168-cd7adns8	1272	6	approximately	approximately	RB
cord-023168-cd7adns8	1272	7	60	60	CD
cord-023168-cd7adns8	1272	8	%	%	NN
cord-023168-cd7adns8	1272	9	of	of	IN
cord-023168-cd7adns8	1272	10	cases	case	NNS
cord-023168-cd7adns8	1272	11	,	,	,
cord-023168-cd7adns8	1272	12	although	although	IN
cord-023168-cd7adns8	1272	13	chronic	chronic	JJ
cord-023168-cd7adns8	1272	14	forms	form	NNS
cord-023168-cd7adns8	1272	15	have	have	VBP
cord-023168-cd7adns8	1272	16	also	also	RB
cord-023168-cd7adns8	1272	17	been	be	VBN
cord-023168-cd7adns8	1272	18	described	describe	VBN
cord-023168-cd7adns8	1272	19	.	.	.
cord-023168-cd7adns8	1273	1	326	326	CD
cord-023168-cd7adns8	1274	1	The	the	DT
cord-023168-cd7adns8	1274	2	clinical	clinical	JJ
cord-023168-cd7adns8	1274	3	presentation	presentation	NN
cord-023168-cd7adns8	1274	4	is	be	VBZ
cord-023168-cd7adns8	1274	5	with	with	IN
cord-023168-cd7adns8	1274	6	generalized	generalized	JJ
cord-023168-cd7adns8	1274	7	lymphadenopathy	lymphadenopathy	NN
cord-023168-cd7adns8	1274	8	in	in	IN
cord-023168-cd7adns8	1274	9	most	most	JJS
cord-023168-cd7adns8	1274	10	cases	case	NNS
cord-023168-cd7adns8	1274	11	and	and	CC
cord-023168-cd7adns8	1274	12	hepatosplenomegaly	hepatosplenomegaly	NNS
cord-023168-cd7adns8	1274	13	in	in	IN
cord-023168-cd7adns8	1274	14	over	over	IN
cord-023168-cd7adns8	1274	15	half	half	NN
cord-023168-cd7adns8	1274	16	.	.	.
cord-023168-cd7adns8	1275	1	324	324	CD
cord-023168-cd7adns8	1275	2	ATLL	ATLL	NNP
cord-023168-cd7adns8	1275	3	is	be	VBZ
cord-023168-cd7adns8	1275	4	associated	associate	VBN
cord-023168-cd7adns8	1275	5	with	with	IN
cord-023168-cd7adns8	1275	6	a	a	DT
cord-023168-cd7adns8	1275	7	high	high	JJ
cord-023168-cd7adns8	1275	8	risk	risk	NN
cord-023168-cd7adns8	1275	9	of	of	IN
cord-023168-cd7adns8	1275	10	hypercalcaemia	hypercalcaemia	NN
cord-023168-cd7adns8	1275	11	which	which	WDT
cord-023168-cd7adns8	1275	12	occurs	occur	VBZ
cord-023168-cd7adns8	1275	13	in	in	IN
cord-023168-cd7adns8	1275	14	more	more	JJR
cord-023168-cd7adns8	1275	15	than	than	IN
cord-023168-cd7adns8	1275	16	two	two	CD
cord-023168-cd7adns8	1275	17	-	-	HYPH
cord-023168-cd7adns8	1275	18	thirds	third	NNS
cord-023168-cd7adns8	1275	19	of	of	IN
cord-023168-cd7adns8	1275	20	patients	patient	NNS
cord-023168-cd7adns8	1275	21	during	during	IN
cord-023168-cd7adns8	1275	22	the	the	DT
cord-023168-cd7adns8	1275	23	course	course	NN
cord-023168-cd7adns8	1275	24	of	of	IN
cord-023168-cd7adns8	1275	25	their	-PRON-	PRP$
cord-023168-cd7adns8	1275	26	disease	disease	NN
cord-023168-cd7adns8	1275	27	and	and	CC
cord-023168-cd7adns8	1275	28	may	may	MD
cord-023168-cd7adns8	1275	29	be	be	VB
cord-023168-cd7adns8	1275	30	associated	associate	VBN
cord-023168-cd7adns8	1275	31	with	with	IN
cord-023168-cd7adns8	1275	32	central	central	JJ
cord-023168-cd7adns8	1275	33	nervous	nervous	JJ
cord-023168-cd7adns8	1275	34	system	system	NN
cord-023168-cd7adns8	1275	35	disturbances	disturbance	NNS
cord-023168-cd7adns8	1275	36	and	and	CC
cord-023168-cd7adns8	1275	37	renal	renal	JJ
cord-023168-cd7adns8	1275	38	impairment	impairment	NN
cord-023168-cd7adns8	1275	39	.	.	.
cord-023168-cd7adns8	1276	1	Lytic	lytic	JJ
cord-023168-cd7adns8	1276	2	bone	bone	NN
cord-023168-cd7adns8	1276	3	lesions	lesion	NNS
cord-023168-cd7adns8	1276	4	occur	occur	VBP
cord-023168-cd7adns8	1276	5	as	as	IN
cord-023168-cd7adns8	1276	6	a	a	DT
cord-023168-cd7adns8	1276	7	para	para	JJ
cord-023168-cd7adns8	1276	8	-	-	HYPH
cord-023168-cd7adns8	1276	9	neoplastic	neoplastic	JJ
cord-023168-cd7adns8	1276	10	Types	type	NNS
cord-023168-cd7adns8	1276	11	of	of	IN
cord-023168-cd7adns8	1276	12	Lymphomas	Lymphomas	NNPS
cord-023168-cd7adns8	1276	13	Identified	identify	VBN
cord-023168-cd7adns8	1276	14	from	from	IN
cord-023168-cd7adns8	1276	15	Selected	Selected	NNP
cord-023168-cd7adns8	1276	16	Countries	Countries	NNPS
cord-023168-cd7adns8	1276	17	in	in	IN
cord-023168-cd7adns8	1276	18	Sub	Sub	NNP
cord-023168-cd7adns8	1276	19	-	-	HYPH
cord-023168-cd7adns8	1276	20	Saharan	Saharan	NNP
cord-023168-cd7adns8	1276	21	Africa	Africa	NNP
cord-023168-cd7adns8	1276	22	phenomenon	phenomenon	NN
cord-023168-cd7adns8	1276	23	due	due	IN
cord-023168-cd7adns8	1276	24	to	to	IN
cord-023168-cd7adns8	1276	25	production	production	NN
cord-023168-cd7adns8	1276	26	of	of	IN
cord-023168-cd7adns8	1276	27	parathormone	parathormone	NN
cord-023168-cd7adns8	1276	28	-	-	HYPH
cord-023168-cd7adns8	1276	29	like	like	JJ
cord-023168-cd7adns8	1276	30	peptides	peptide	NNS
cord-023168-cd7adns8	1276	31	.	.	.
cord-023168-cd7adns8	1277	1	As	as	IN
cord-023168-cd7adns8	1277	2	with	with	IN
cord-023168-cd7adns8	1277	3	other	other	JJ
cord-023168-cd7adns8	1277	4	T	t	NN
cord-023168-cd7adns8	1277	5	-	-	HYPH
cord-023168-cd7adns8	1277	6	cell	cell	NN
cord-023168-cd7adns8	1277	7	disorders	disorder	NNS
cord-023168-cd7adns8	1277	8	,	,	,
cord-023168-cd7adns8	1277	9	ATLL	ATLL	NNP
cord-023168-cd7adns8	1277	10	can	can	MD
cord-023168-cd7adns8	1277	11	involve	involve	VB
cord-023168-cd7adns8	1277	12	the	the	DT
cord-023168-cd7adns8	1277	13	skin	skin	NN
cord-023168-cd7adns8	1277	14	,	,	,
cord-023168-cd7adns8	1277	15	producing	produce	VBG
cord-023168-cd7adns8	1277	16	,	,	,
cord-023168-cd7adns8	1277	17	e.g.	e.g.	IN
cord-023168-cd7adns8	1277	18	erythrodermic	erythrodermic	JJ
cord-023168-cd7adns8	1277	19	plaques	plaque	NNS
cord-023168-cd7adns8	1277	20	.	.	.
cord-023168-cd7adns8	1278	1	The	the	DT
cord-023168-cd7adns8	1278	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1278	3	of	of	IN
cord-023168-cd7adns8	1278	4	ATLL	ATLL	NNP
cord-023168-cd7adns8	1278	5	can	can	MD
cord-023168-cd7adns8	1278	6	be	be	VB
cord-023168-cd7adns8	1278	7	suspected	suspect	VBN
cord-023168-cd7adns8	1278	8	from	from	IN
cord-023168-cd7adns8	1278	9	a	a	DT
cord-023168-cd7adns8	1278	10	high	high	JJ
cord-023168-cd7adns8	1278	11	peripheral	peripheral	JJ
cord-023168-cd7adns8	1278	12	blood	blood	NN
cord-023168-cd7adns8	1278	13	white	white	JJ
cord-023168-cd7adns8	1278	14	blood	blood	NN
cord-023168-cd7adns8	1278	15	cell	cell	NN
cord-023168-cd7adns8	1278	16	count	count	NN
cord-023168-cd7adns8	1278	17	in	in	IN
cord-023168-cd7adns8	1278	18	combination	combination	NN
cord-023168-cd7adns8	1278	19	with	with	IN
cord-023168-cd7adns8	1278	20	hypercalcaemia	hypercalcaemia	NN
cord-023168-cd7adns8	1278	21	and	and	CC
cord-023168-cd7adns8	1278	22	characteristic	characteristic	JJ
cord-023168-cd7adns8	1278	23	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	1278	24	with	with	IN
cord-023168-cd7adns8	1278	25	convoluted	convoluted	JJ
cord-023168-cd7adns8	1278	26	and	and	CC
cord-023168-cd7adns8	1278	27	hyperlobulated	hyperlobulated	JJ
cord-023168-cd7adns8	1278	28	nuclei	nucleus	NNS
cord-023168-cd7adns8	1278	29	.	.	.
cord-023168-cd7adns8	1279	1	324	324	CD
cord-023168-cd7adns8	1280	1	The	the	DT
cord-023168-cd7adns8	1280	2	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1280	3	is	be	VBZ
cord-023168-cd7adns8	1280	4	confirmed	confirm	VBN
cord-023168-cd7adns8	1280	5	by	by	IN
cord-023168-cd7adns8	1280	6	histological	histological	JJ
cord-023168-cd7adns8	1280	7	examination	examination	NN
cord-023168-cd7adns8	1280	8	of	of	IN
cord-023168-cd7adns8	1280	9	a	a	DT
cord-023168-cd7adns8	1280	10	tissue	tissue	NN
cord-023168-cd7adns8	1280	11	(	(	-LRB-
cord-023168-cd7adns8	1280	12	lymph	lymph	NN
cord-023168-cd7adns8	1280	13	node	node	NN
cord-023168-cd7adns8	1280	14	or	or	CC
cord-023168-cd7adns8	1280	15	bone	bone	NN
cord-023168-cd7adns8	1280	16	marrow	marrow	NN
cord-023168-cd7adns8	1280	17	)	)	-RRB-
cord-023168-cd7adns8	1280	18	,	,	,
cord-023168-cd7adns8	1280	19	immunophenotyping	immunophenotype	VBG
cord-023168-cd7adns8	1280	20	for	for	IN
cord-023168-cd7adns8	1280	21	specific	specific	JJ
cord-023168-cd7adns8	1280	22	cell	cell	NN
cord-023168-cd7adns8	1280	23	markers	marker	NNS
cord-023168-cd7adns8	1280	24	and	and	CC
cord-023168-cd7adns8	1280	25	proof	proof	NN
cord-023168-cd7adns8	1280	26	of	of	IN
cord-023168-cd7adns8	1280	27	HTLV	HTLV	NNP
cord-023168-cd7adns8	1280	28	infection	infection	NN
cord-023168-cd7adns8	1280	29	,	,	,
cord-023168-cd7adns8	1280	30	usually	usually	RB
cord-023168-cd7adns8	1280	31	by	by	IN
cord-023168-cd7adns8	1280	32	serological	serological	JJ
cord-023168-cd7adns8	1280	33	methods	method	NNS
cord-023168-cd7adns8	1280	34	.	.	.
cord-023168-cd7adns8	1281	1	Management	management	NN
cord-023168-cd7adns8	1281	2	of	of	IN
cord-023168-cd7adns8	1281	3	ATLL	ATLL	NNP
cord-023168-cd7adns8	1281	4	is	be	VBZ
cord-023168-cd7adns8	1281	5	primarily	primarily	RB
cord-023168-cd7adns8	1281	6	with	with	IN
cord-023168-cd7adns8	1281	7	combination	combination	NN
cord-023168-cd7adns8	1281	8	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1281	9	with	with	IN
cord-023168-cd7adns8	1281	10	intrathecal	intrathecal	JJ
cord-023168-cd7adns8	1281	11	prophylaxis	prophylaxis	NN
cord-023168-cd7adns8	1281	12	.	.	.
cord-023168-cd7adns8	1282	1	327,328	327,328	CD
cord-023168-cd7adns8	1282	2	A	a	DT
cord-023168-cd7adns8	1282	3	combination	combination	NN
cord-023168-cd7adns8	1282	4	of	of	IN
cord-023168-cd7adns8	1282	5	zidovudine	zidovudine	NN
cord-023168-cd7adns8	1282	6	and	and	CC
cord-023168-cd7adns8	1282	7	interferon	interferon	NN
cord-023168-cd7adns8	1282	8	,	,	,
cord-023168-cd7adns8	1282	9	as	as	IN
cord-023168-cd7adns8	1282	10	agents	agent	NNS
cord-023168-cd7adns8	1282	11	against	against	IN
cord-023168-cd7adns8	1282	12	HTLV	HTLV	NNP
cord-023168-cd7adns8	1282	13	,	,	,
cord-023168-cd7adns8	1282	14	has	have	VBZ
cord-023168-cd7adns8	1282	15	also	also	RB
cord-023168-cd7adns8	1282	16	been	be	VBN
cord-023168-cd7adns8	1282	17	tried	try	VBN
cord-023168-cd7adns8	1282	18	with	with	IN
cord-023168-cd7adns8	1282	19	some	some	DT
cord-023168-cd7adns8	1282	20	success	success	NN
cord-023168-cd7adns8	1282	21	.	.	.
cord-023168-cd7adns8	1283	1	329	329	CD
cord-023168-cd7adns8	1283	2	Hypercalcaemia	hypercalcaemia	NN
cord-023168-cd7adns8	1283	3	and	and	CC
cord-023168-cd7adns8	1283	4	opportunistic	opportunistic	JJ
cord-023168-cd7adns8	1283	5	infections	infection	NNS
cord-023168-cd7adns8	1283	6	should	should	MD
cord-023168-cd7adns8	1283	7	be	be	VB
cord-023168-cd7adns8	1283	8	sought	seek	VBN
cord-023168-cd7adns8	1283	9	and	and	CC
cord-023168-cd7adns8	1283	10	treated	treat	VBN
cord-023168-cd7adns8	1283	11	early	early	RB
cord-023168-cd7adns8	1283	12	in	in	IN
cord-023168-cd7adns8	1283	13	these	these	DT
cord-023168-cd7adns8	1283	14	patients	patient	NNS
cord-023168-cd7adns8	1283	15	.	.	.
cord-023168-cd7adns8	1284	1	The	the	DT
cord-023168-cd7adns8	1284	2	high	high	JJ
cord-023168-cd7adns8	1284	3	white	white	JJ
cord-023168-cd7adns8	1284	4	cell	cell	NN
cord-023168-cd7adns8	1284	5	count	count	NN
cord-023168-cd7adns8	1284	6	is	be	VBZ
cord-023168-cd7adns8	1284	7	associated	associate	VBN
cord-023168-cd7adns8	1284	8	with	with	IN
cord-023168-cd7adns8	1284	9	a	a	DT
cord-023168-cd7adns8	1284	10	significant	significant	JJ
cord-023168-cd7adns8	1284	11	risk	risk	NN
cord-023168-cd7adns8	1284	12	of	of	IN
cord-023168-cd7adns8	1284	13	tumour	tumour	NN
cord-023168-cd7adns8	1284	14	lysis	lysis	NN
cord-023168-cd7adns8	1284	15	syndrome	syndrome	NN
cord-023168-cd7adns8	1284	16	and	and	CC
cord-023168-cd7adns8	1284	17	should	should	MD
cord-023168-cd7adns8	1284	18	be	be	VB
cord-023168-cd7adns8	1284	19	prevented	prevent	VBN
cord-023168-cd7adns8	1284	20	by	by	IN
cord-023168-cd7adns8	1284	21	adequate	adequate	JJ
cord-023168-cd7adns8	1284	22	hydration	hydration	NN
cord-023168-cd7adns8	1284	23	and	and	CC
cord-023168-cd7adns8	1284	24	the	the	DT
cord-023168-cd7adns8	1284	25	judicious	judicious	JJ
cord-023168-cd7adns8	1284	26	use	use	NN
cord-023168-cd7adns8	1284	27	of	of	IN
cord-023168-cd7adns8	1284	28	allopurinol	allopurinol	NN
cord-023168-cd7adns8	1284	29	and	and	CC
cord-023168-cd7adns8	1284	30	other	other	JJ
cord-023168-cd7adns8	1284	31	urate	urate	NN
cord-023168-cd7adns8	1284	32	-	-	HYPH
cord-023168-cd7adns8	1284	33	reducing	reduce	VBG
cord-023168-cd7adns8	1284	34	agents	agent	NNS
cord-023168-cd7adns8	1284	35	.	.	.
cord-023168-cd7adns8	1285	1	Myeloma	myeloma	NN
cord-023168-cd7adns8	1285	2	is	be	VBZ
cord-023168-cd7adns8	1285	3	a	a	DT
cord-023168-cd7adns8	1285	4	monoclonal	monoclonal	JJ
cord-023168-cd7adns8	1285	5	proliferation	proliferation	NN
cord-023168-cd7adns8	1285	6	of	of	IN
cord-023168-cd7adns8	1285	7	plasma	plasma	NN
cord-023168-cd7adns8	1285	8	cells	cell	NNS
cord-023168-cd7adns8	1285	9	and	and	CC
cord-023168-cd7adns8	1285	10	it	-PRON-	PRP
cord-023168-cd7adns8	1285	11	particularly	particularly	RB
cord-023168-cd7adns8	1285	12	affects	affect	VBZ
cord-023168-cd7adns8	1285	13	older	old	JJR
cord-023168-cd7adns8	1285	14	people	people	NNS
cord-023168-cd7adns8	1285	15	.	.	.
cord-023168-cd7adns8	1286	1	Myeloma	myeloma	NN
cord-023168-cd7adns8	1286	2	appears	appear	VBZ
cord-023168-cd7adns8	1286	3	to	to	TO
cord-023168-cd7adns8	1286	4	be	be	VB
cord-023168-cd7adns8	1286	5	less	less	RBR
cord-023168-cd7adns8	1286	6	common	common	JJ
cord-023168-cd7adns8	1286	7	in	in	IN
cord-023168-cd7adns8	1286	8	Asian	asian	JJ
cord-023168-cd7adns8	1286	9	countries	country	NNS
cord-023168-cd7adns8	1286	10	than	than	IN
cord-023168-cd7adns8	1286	11	elsewhere	elsewhere	RB
cord-023168-cd7adns8	1286	12	,	,	,
cord-023168-cd7adns8	1286	13	although	although	IN
cord-023168-cd7adns8	1286	14	during	during	IN
cord-023168-cd7adns8	1286	15	the	the	DT
cord-023168-cd7adns8	1286	16	last	last	JJ
cord-023168-cd7adns8	1286	17	25	25	CD
cord-023168-cd7adns8	1286	18	years	year	NNS
cord-023168-cd7adns8	1286	19	,	,	,
cord-023168-cd7adns8	1286	20	an	an	DT
cord-023168-cd7adns8	1286	21	almost	almost	RB
cord-023168-cd7adns8	1286	22	four	four	CD
cord-023168-cd7adns8	1286	23	-	-	JJ
cord-023168-cd7adns8	1286	24	fold	fold	JJ
cord-023168-cd7adns8	1286	25	increase	increase	NN
cord-023168-cd7adns8	1286	26	in	in	IN
cord-023168-cd7adns8	1286	27	incidence	incidence	NN
cord-023168-cd7adns8	1286	28	of	of	IN
cord-023168-cd7adns8	1286	29	myeloma	myeloma	NN
cord-023168-cd7adns8	1286	30	has	have	VBZ
cord-023168-cd7adns8	1286	31	occurred	occur	VBN
cord-023168-cd7adns8	1286	32	in	in	IN
cord-023168-cd7adns8	1286	33	Taiwan	Taiwan	NNP
cord-023168-cd7adns8	1286	34	.	.	.
cord-023168-cd7adns8	1287	1	330	330	CD
cord-023168-cd7adns8	1288	1	In	in	IN
cord-023168-cd7adns8	1288	2	the	the	DT
cord-023168-cd7adns8	1288	3	United	United	NNP
cord-023168-cd7adns8	1288	4	States	States	NNP
cord-023168-cd7adns8	1288	5	,	,	,
cord-023168-cd7adns8	1288	6	the	the	DT
cord-023168-cd7adns8	1288	7	incidence	incidence	NN
cord-023168-cd7adns8	1288	8	of	of	IN
cord-023168-cd7adns8	1288	9	multiple	multiple	JJ
cord-023168-cd7adns8	1288	10	myeloma	myeloma	NN
cord-023168-cd7adns8	1288	11	in	in	IN
cord-023168-cd7adns8	1288	12	the	the	DT
cord-023168-cd7adns8	1288	13	black	black	JJ
cord-023168-cd7adns8	1288	14	population	population	NN
cord-023168-cd7adns8	1288	15	is	be	VBZ
cord-023168-cd7adns8	1288	16	twice	twice	PDT
cord-023168-cd7adns8	1288	17	that	that	DT
cord-023168-cd7adns8	1288	18	of	of	IN
cord-023168-cd7adns8	1288	19	the	the	DT
cord-023168-cd7adns8	1288	20	white	white	JJ
cord-023168-cd7adns8	1288	21	population	population	NN
cord-023168-cd7adns8	1288	22	.	.	.
cord-023168-cd7adns8	1289	1	The	the	DT
cord-023168-cd7adns8	1289	2	abundant	abundant	JJ
cord-023168-cd7adns8	1289	3	plasma	plasma	NN
cord-023168-cd7adns8	1289	4	cells	cell	NNS
cord-023168-cd7adns8	1289	5	infiltrate	infiltrate	VBP
cord-023168-cd7adns8	1289	6	the	the	DT
cord-023168-cd7adns8	1289	7	bone	bone	NN
cord-023168-cd7adns8	1289	8	marrow	marrow	NN
cord-023168-cd7adns8	1289	9	and	and	CC
cord-023168-cd7adns8	1289	10	interfere	interfere	VB
cord-023168-cd7adns8	1289	11	with	with	IN
cord-023168-cd7adns8	1289	12	normal	normal	JJ
cord-023168-cd7adns8	1289	13	haematopoiesis	haematopoiesis	NN
cord-023168-cd7adns8	1289	14	.	.	.
cord-023168-cd7adns8	1290	1	This	this	DT
cord-023168-cd7adns8	1290	2	leads	lead	VBZ
cord-023168-cd7adns8	1290	3	to	to	IN
cord-023168-cd7adns8	1290	4	anaemia	anaemia	NN
cord-023168-cd7adns8	1290	5	,	,	,
cord-023168-cd7adns8	1290	6	which	which	WDT
cord-023168-cd7adns8	1290	7	is	be	VBZ
cord-023168-cd7adns8	1290	8	a	a	DT
cord-023168-cd7adns8	1290	9	presenting	present	VBG
cord-023168-cd7adns8	1290	10	feature	feature	NN
cord-023168-cd7adns8	1290	11	in	in	IN
cord-023168-cd7adns8	1290	12	70	70	CD
cord-023168-cd7adns8	1290	13	%	%	NN
cord-023168-cd7adns8	1290	14	of	of	IN
cord-023168-cd7adns8	1290	15	individuals	individual	NNS
cord-023168-cd7adns8	1290	16	.	.	.
cord-023168-cd7adns8	1291	1	Bony	bony	JJ
cord-023168-cd7adns8	1291	2	infiltration	infiltration	NN
cord-023168-cd7adns8	1291	3	by	by	IN
cord-023168-cd7adns8	1291	4	the	the	DT
cord-023168-cd7adns8	1291	5	malignant	malignant	JJ
cord-023168-cd7adns8	1291	6	plasma	plasma	NN
cord-023168-cd7adns8	1291	7	cells	cell	NNS
cord-023168-cd7adns8	1291	8	can	can	MD
cord-023168-cd7adns8	1291	9	produce	produce	VB
cord-023168-cd7adns8	1291	10	osteoporosis	osteoporosis	NN
cord-023168-cd7adns8	1291	11	,	,	,
cord-023168-cd7adns8	1291	12	lytic	lytic	JJ
cord-023168-cd7adns8	1291	13	lesions	lesion	NNS
cord-023168-cd7adns8	1291	14	and	and	CC
cord-023168-cd7adns8	1291	15	pathological	pathological	JJ
cord-023168-cd7adns8	1291	16	fractures	fracture	NNS
cord-023168-cd7adns8	1291	17	in	in	IN
cord-023168-cd7adns8	1291	18	60	60	CD
cord-023168-cd7adns8	1291	19	%	%	NN
cord-023168-cd7adns8	1291	20	of	of	IN
cord-023168-cd7adns8	1291	21	patients	patient	NNS
cord-023168-cd7adns8	1291	22	with	with	IN
cord-023168-cd7adns8	1291	23	myeloma	myeloma	NN
cord-023168-cd7adns8	1291	24	.	.	.
cord-023168-cd7adns8	1292	1	Involvement	involvement	NN
cord-023168-cd7adns8	1292	2	of	of	IN
cord-023168-cd7adns8	1292	3	the	the	DT
cord-023168-cd7adns8	1292	4	bones	bone	NNS
cord-023168-cd7adns8	1292	5	can	can	MD
cord-023168-cd7adns8	1292	6	lead	lead	VB
cord-023168-cd7adns8	1292	7	to	to	IN
cord-023168-cd7adns8	1292	8	hypercalcaemia	hypercalcaemia	NNP
cord-023168-cd7adns8	1292	9	,	,	,
cord-023168-cd7adns8	1292	10	which	which	WDT
cord-023168-cd7adns8	1292	11	may	may	MD
cord-023168-cd7adns8	1292	12	be	be	VB
cord-023168-cd7adns8	1292	13	a	a	DT
cord-023168-cd7adns8	1292	14	presenting	present	VBG
cord-023168-cd7adns8	1292	15	feature	feature	NN
cord-023168-cd7adns8	1292	16	,	,	,
cord-023168-cd7adns8	1292	17	and	and	CC
cord-023168-cd7adns8	1292	18	vertebral	vertebral	JJ
cord-023168-cd7adns8	1292	19	fracture	fracture	NN
cord-023168-cd7adns8	1292	20	leading	lead	VBG
cord-023168-cd7adns8	1292	21	to	to	IN
cord-023168-cd7adns8	1292	22	spinal	spinal	JJ
cord-023168-cd7adns8	1292	23	cord	cord	NN
cord-023168-cd7adns8	1292	24	compression	compression	NN
cord-023168-cd7adns8	1292	25	.	.	.
cord-023168-cd7adns8	1293	1	The	the	DT
cord-023168-cd7adns8	1293	2	malignant	malignant	JJ
cord-023168-cd7adns8	1293	3	plasma	plasma	NN
cord-023168-cd7adns8	1293	4	cells	cell	NNS
cord-023168-cd7adns8	1293	5	produce	produce	VBP
cord-023168-cd7adns8	1293	6	a	a	DT
cord-023168-cd7adns8	1293	7	paraprotein	paraprotein	NN
cord-023168-cd7adns8	1293	8	which	which	WDT
cord-023168-cd7adns8	1293	9	can	can	MD
cord-023168-cd7adns8	1293	10	cause	cause	VB
cord-023168-cd7adns8	1293	11	renal	renal	JJ
cord-023168-cd7adns8	1293	12	impairment	impairment	NN
cord-023168-cd7adns8	1293	13	in	in	IN
cord-023168-cd7adns8	1293	14	20	20	CD
cord-023168-cd7adns8	1293	15	-	-	SYM
cord-023168-cd7adns8	1293	16	50	50	CD
cord-023168-cd7adns8	1293	17	%	%	NN
cord-023168-cd7adns8	1293	18	and	and	CC
cord-023168-cd7adns8	1293	19	hyperviscosity	hyperviscosity	NN
cord-023168-cd7adns8	1293	20	may	may	MD
cord-023168-cd7adns8	1293	21	ensue	ensue	VB
cord-023168-cd7adns8	1293	22	in	in	IN
cord-023168-cd7adns8	1293	23	10	10	CD
cord-023168-cd7adns8	1293	24	%	%	NN
cord-023168-cd7adns8	1293	25	of	of	IN
cord-023168-cd7adns8	1293	26	patients	patient	NNS
cord-023168-cd7adns8	1293	27	if	if	IN
cord-023168-cd7adns8	1293	28	the	the	DT
cord-023168-cd7adns8	1293	29	paraprotein	paraprotein	NNP
cord-023168-cd7adns8	1293	30	production	production	NN
cord-023168-cd7adns8	1293	31	is	be	VBZ
cord-023168-cd7adns8	1293	32	not	not	RB
cord-023168-cd7adns8	1293	33	controlled	control	VBN
cord-023168-cd7adns8	1293	34	.	.	.
cord-023168-cd7adns8	1294	1	Patients	patient	NNS
cord-023168-cd7adns8	1294	2	with	with	IN
cord-023168-cd7adns8	1294	3	myeloma	myeloma	NN
cord-023168-cd7adns8	1294	4	may	may	MD
cord-023168-cd7adns8	1294	5	need	need	VB
cord-023168-cd7adns8	1294	6	a	a	DT
cord-023168-cd7adns8	1294	7	variety	variety	NN
cord-023168-cd7adns8	1294	8	of	of	IN
cord-023168-cd7adns8	1294	9	supportive	supportive	JJ
cord-023168-cd7adns8	1294	10	interventions	intervention	NNS
cord-023168-cd7adns8	1294	11	including	include	VBG
cord-023168-cd7adns8	1294	12	management	management	NN
cord-023168-cd7adns8	1294	13	of	of	IN
cord-023168-cd7adns8	1294	14	anaemia	anaemia	NN
cord-023168-cd7adns8	1294	15	,	,	,
cord-023168-cd7adns8	1294	16	renal	renal	JJ
cord-023168-cd7adns8	1294	17	failure	failure	NN
cord-023168-cd7adns8	1294	18	,	,	,
cord-023168-cd7adns8	1294	19	hypercalcaemia	hypercalcaemia	NN
cord-023168-cd7adns8	1294	20	,	,	,
cord-023168-cd7adns8	1294	21	hyperviscosity	hyperviscosity	NN
cord-023168-cd7adns8	1294	22	,	,	,
cord-023168-cd7adns8	1294	23	infections	infection	NNS
cord-023168-cd7adns8	1294	24	and	and	CC
cord-023168-cd7adns8	1294	25	bone	bone	NN
cord-023168-cd7adns8	1294	26	pains	pain	NNS
cord-023168-cd7adns8	1294	27	.	.	.
cord-023168-cd7adns8	1295	1	Specific	specific	JJ
cord-023168-cd7adns8	1295	2	anti	anti	JJ
cord-023168-cd7adns8	1295	3	-	-	JJ
cord-023168-cd7adns8	1295	4	myeloma	myeloma	JJ
cord-023168-cd7adns8	1295	5	treatment	treatment	NN
cord-023168-cd7adns8	1295	6	should	should	MD
cord-023168-cd7adns8	1295	7	be	be	VB
cord-023168-cd7adns8	1295	8	managed	manage	VBN
cord-023168-cd7adns8	1295	9	within	within	IN
cord-023168-cd7adns8	1295	10	a	a	DT
cord-023168-cd7adns8	1295	11	specialist	specialist	JJ
cord-023168-cd7adns8	1295	12	unit	unit	NN
cord-023168-cd7adns8	1295	13	and	and	CC
cord-023168-cd7adns8	1295	14	has	have	VBZ
cord-023168-cd7adns8	1295	15	undergone	undergo	VBN
cord-023168-cd7adns8	1295	16	a	a	DT
cord-023168-cd7adns8	1295	17	radical	radical	JJ
cord-023168-cd7adns8	1295	18	change	change	NN
cord-023168-cd7adns8	1295	19	in	in	IN
cord-023168-cd7adns8	1295	20	the	the	DT
cord-023168-cd7adns8	1295	21	last	last	JJ
cord-023168-cd7adns8	1295	22	decade	decade	NN
cord-023168-cd7adns8	1295	23	with	with	IN
cord-023168-cd7adns8	1295	24	the	the	DT
cord-023168-cd7adns8	1295	25	use	use	NN
cord-023168-cd7adns8	1295	26	of	of	IN
cord-023168-cd7adns8	1295	27	thalidomide	thalidomide	NN
cord-023168-cd7adns8	1295	28	and	and	CC
cord-023168-cd7adns8	1295	29	its	-PRON-	PRP$
cord-023168-cd7adns8	1295	30	newer	new	JJR
cord-023168-cd7adns8	1295	31	formulations	formulation	NNS
cord-023168-cd7adns8	1295	32	,	,	,
cord-023168-cd7adns8	1295	33	and	and	CC
cord-023168-cd7adns8	1295	34	the	the	DT
cord-023168-cd7adns8	1295	35	more	more	RBR
cord-023168-cd7adns8	1295	36	expensive	expensive	JJ
cord-023168-cd7adns8	1295	37	,	,	,
cord-023168-cd7adns8	1295	38	proteasome	proteasome	NN
cord-023168-cd7adns8	1295	39	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1295	40	(	(	-LRB-
cord-023168-cd7adns8	1295	41	e.g.	e.g.	IN
cord-023168-cd7adns8	1295	42	bortzomib	bortzomib	NNP
cord-023168-cd7adns8	1295	43	)	)	-RRB-
cord-023168-cd7adns8	1295	44	.	.	.
cord-023168-cd7adns8	1296	1	Thalidomide	Thalidomide	NNP
cord-023168-cd7adns8	1296	2	is	be	VBZ
cord-023168-cd7adns8	1296	3	relatively	relatively	RB
cord-023168-cd7adns8	1296	4	safe	safe	JJ
cord-023168-cd7adns8	1296	5	and	and	CC
cord-023168-cd7adns8	1296	6	effective	effective	JJ
cord-023168-cd7adns8	1296	7	although	although	IN
cord-023168-cd7adns8	1296	8	somnolence	somnolence	NN
cord-023168-cd7adns8	1296	9	and	and	CC
cord-023168-cd7adns8	1296	10	constipation	constipation	NN
cord-023168-cd7adns8	1296	11	can	can	MD
cord-023168-cd7adns8	1296	12	sometimes	sometimes	RB
cord-023168-cd7adns8	1296	13	be	be	VB
cord-023168-cd7adns8	1296	14	troublesome	troublesome	JJ
cord-023168-cd7adns8	1296	15	.	.	.
cord-023168-cd7adns8	1297	1	There	there	EX
cord-023168-cd7adns8	1297	2	is	be	VBZ
cord-023168-cd7adns8	1297	3	a	a	DT
cord-023168-cd7adns8	1297	4	risk	risk	NN
cord-023168-cd7adns8	1297	5	of	of	IN
cord-023168-cd7adns8	1297	6	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1297	7	with	with	IN
cord-023168-cd7adns8	1297	8	thalidomide	thalidomide	NN
cord-023168-cd7adns8	1297	9	especially	especially	RB
cord-023168-cd7adns8	1297	10	at	at	IN
cord-023168-cd7adns8	1297	11	the	the	DT
cord-023168-cd7adns8	1297	12	initiation	initiation	NN
cord-023168-cd7adns8	1297	13	of	of	IN
cord-023168-cd7adns8	1297	14	therapy	therapy	NN
cord-023168-cd7adns8	1297	15	,	,	,
cord-023168-cd7adns8	1297	16	and	and	CC
cord-023168-cd7adns8	1297	17	prophylaxis	prophylaxis	NN
cord-023168-cd7adns8	1297	18	with	with	IN
cord-023168-cd7adns8	1297	19	heparin	heparin	NN
cord-023168-cd7adns8	1297	20	,	,	,
cord-023168-cd7adns8	1297	21	warfarin	warfarin	NN
cord-023168-cd7adns8	1297	22	or	or	CC
cord-023168-cd7adns8	1297	23	antiplatelet	antiplatelet	NN
cord-023168-cd7adns8	1297	24	agents	agent	NNS
cord-023168-cd7adns8	1297	25	,	,	,
cord-023168-cd7adns8	1297	26	depending	depend	VBG
cord-023168-cd7adns8	1297	27	on	on	IN
cord-023168-cd7adns8	1297	28	an	an	DT
cord-023168-cd7adns8	1297	29	assessment	assessment	NN
cord-023168-cd7adns8	1297	30	of	of	IN
cord-023168-cd7adns8	1297	31	the	the	DT
cord-023168-cd7adns8	1297	32	risk	risk	NN
cord-023168-cd7adns8	1297	33	,	,	,
cord-023168-cd7adns8	1297	34	may	may	MD
cord-023168-cd7adns8	1297	35	be	be	VB
cord-023168-cd7adns8	1297	36	warranted	warrant	VBN
cord-023168-cd7adns8	1297	37	.	.	.
cord-023168-cd7adns8	1298	1	Melphalan	Melphalan	NNP
cord-023168-cd7adns8	1298	2	may	may	MD
cord-023168-cd7adns8	1298	3	also	also	RB
cord-023168-cd7adns8	1298	4	be	be	VB
cord-023168-cd7adns8	1298	5	useful	useful	JJ
cord-023168-cd7adns8	1298	6	,	,	,
cord-023168-cd7adns8	1298	7	particularly	particularly	RB
cord-023168-cd7adns8	1298	8	if	if	IN
cord-023168-cd7adns8	1298	9	resources	resource	NNS
cord-023168-cd7adns8	1298	10	are	be	VBP
cord-023168-cd7adns8	1298	11	limited	limited	JJ
cord-023168-cd7adns8	1298	12	and	and	CC
cord-023168-cd7adns8	1298	13	there	there	EX
cord-023168-cd7adns8	1298	14	is	be	VBZ
cord-023168-cd7adns8	1298	15	no	no	DT
cord-023168-cd7adns8	1298	16	specialist	specialist	JJ
cord-023168-cd7adns8	1298	17	centre	centre	NN
cord-023168-cd7adns8	1298	18	.	.	.
cord-023168-cd7adns8	1299	1	However	however	RB
cord-023168-cd7adns8	1299	2	it	-PRON-	PRP
cord-023168-cd7adns8	1299	3	is	be	VBZ
cord-023168-cd7adns8	1299	4	myelosuppressive	myelosuppressive	JJ
cord-023168-cd7adns8	1299	5	,	,	,
cord-023168-cd7adns8	1299	6	so	so	RB
cord-023168-cd7adns8	1299	7	regular	regular	JJ
cord-023168-cd7adns8	1299	8	monitoring	monitoring	NN
cord-023168-cd7adns8	1299	9	of	of	IN
cord-023168-cd7adns8	1299	10	the	the	DT
cord-023168-cd7adns8	1299	11	blood	blood	NN
cord-023168-cd7adns8	1299	12	count	count	NN
cord-023168-cd7adns8	1299	13	is	be	VBZ
cord-023168-cd7adns8	1299	14	essential	essential	JJ
cord-023168-cd7adns8	1299	15	.	.	.
cord-023168-cd7adns8	1300	1	Maintaining	maintain	VBG
cord-023168-cd7adns8	1300	2	an	an	DT
cord-023168-cd7adns8	1300	3	adequate	adequate	JJ
cord-023168-cd7adns8	1300	4	blood	blood	NN
cord-023168-cd7adns8	1300	5	supply	supply	NN
cord-023168-cd7adns8	1300	6	is	be	VBZ
cord-023168-cd7adns8	1300	7	a	a	DT
cord-023168-cd7adns8	1300	8	major	major	JJ
cord-023168-cd7adns8	1300	9	challenge	challenge	NN
cord-023168-cd7adns8	1300	10	for	for	IN
cord-023168-cd7adns8	1300	11	low	low	JJ
cord-023168-cd7adns8	1300	12	-	-	HYPH
cord-023168-cd7adns8	1300	13	income	income	NN
cord-023168-cd7adns8	1300	14	countries	country	NNS
cord-023168-cd7adns8	1300	15	.	.	.
cord-023168-cd7adns8	1301	1	Only	only	RB
cord-023168-cd7adns8	1301	2	39	39	CD
cord-023168-cd7adns8	1301	3	%	%	NN
cord-023168-cd7adns8	1301	4	of	of	IN
cord-023168-cd7adns8	1301	5	the	the	DT
cord-023168-cd7adns8	1301	6	global	global	JJ
cord-023168-cd7adns8	1301	7	blood	blood	NN
cord-023168-cd7adns8	1301	8	supply	supply	NN
cord-023168-cd7adns8	1301	9	is	be	VBZ
cord-023168-cd7adns8	1301	10	donated	donate	VBN
cord-023168-cd7adns8	1301	11	in	in	IN
cord-023168-cd7adns8	1301	12	the	the	DT
cord-023168-cd7adns8	1301	13	poorest	poor	JJS
cord-023168-cd7adns8	1301	14	countries	country	NNS
cord-023168-cd7adns8	1301	15	where	where	WRB
cord-023168-cd7adns8	1301	16	82	82	CD
cord-023168-cd7adns8	1301	17	%	%	NN
cord-023168-cd7adns8	1301	18	of	of	IN
cord-023168-cd7adns8	1301	19	the	the	DT
cord-023168-cd7adns8	1301	20	world	world	NN
cord-023168-cd7adns8	1301	21	's	's	POS
cord-023168-cd7adns8	1301	22	population	population	NN
cord-023168-cd7adns8	1301	23	lives	live	VBZ
cord-023168-cd7adns8	1301	24	.	.	.
cord-023168-cd7adns8	1302	1	331	331	CD
cord-023168-cd7adns8	1302	2	Blood	blood	NN
cord-023168-cd7adns8	1302	3	transfusion	transfusion	NN
cord-023168-cd7adns8	1302	4	is	be	VBZ
cord-023168-cd7adns8	1302	5	a	a	DT
cord-023168-cd7adns8	1302	6	vital	vital	JJ
cord-023168-cd7adns8	1302	7	component	component	NN
cord-023168-cd7adns8	1302	8	of	of	IN
cord-023168-cd7adns8	1302	9	every	every	DT
cord-023168-cd7adns8	1302	10	country	country	NN
cord-023168-cd7adns8	1302	11	's	's	POS
cord-023168-cd7adns8	1302	12	health	health	NN
cord-023168-cd7adns8	1302	13	service	service	NN
cord-023168-cd7adns8	1302	14	.	.	.
cord-023168-cd7adns8	1303	1	It	-PRON-	PRP
cord-023168-cd7adns8	1303	2	can	can	MD
cord-023168-cd7adns8	1303	3	be	be	VB
cord-023168-cd7adns8	1303	4	a	a	DT
cord-023168-cd7adns8	1303	5	life	life	NN
cord-023168-cd7adns8	1303	6	-	-	HYPH
cord-023168-cd7adns8	1303	7	saving	save	VBG
cord-023168-cd7adns8	1303	8	intervention	intervention	NN
cord-023168-cd7adns8	1303	9	for	for	IN
cord-023168-cd7adns8	1303	10	illnesses	illness	NNS
cord-023168-cd7adns8	1303	11	such	such	JJ
cord-023168-cd7adns8	1303	12	as	as	IN
cord-023168-cd7adns8	1303	13	severe	severe	JJ
cord-023168-cd7adns8	1303	14	acute	acute	JJ
cord-023168-cd7adns8	1303	15	anaemia	anaemia	NN
cord-023168-cd7adns8	1303	16	,	,	,
cord-023168-cd7adns8	1303	17	but	but	CC
cord-023168-cd7adns8	1303	18	mistakes	mistake	NNS
cord-023168-cd7adns8	1303	19	in	in	IN
cord-023168-cd7adns8	1303	20	the	the	DT
cord-023168-cd7adns8	1303	21	transfusion	transfusion	NN
cord-023168-cd7adns8	1303	22	process	process	NN
cord-023168-cd7adns8	1303	23	can	can	MD
cord-023168-cd7adns8	1303	24	be	be	VB
cord-023168-cd7adns8	1303	25	life	life	NN
cord-023168-cd7adns8	1303	26	-	-	HYPH
cord-023168-cd7adns8	1303	27	threatening	threaten	VBG
cord-023168-cd7adns8	1303	28	,	,	,
cord-023168-cd7adns8	1303	29	either	either	CC
cord-023168-cd7adns8	1303	30	immediately	immediately	RB
cord-023168-cd7adns8	1303	31	or	or	CC
cord-023168-cd7adns8	1303	32	years	year	NNS
cord-023168-cd7adns8	1303	33	later	later	RB
cord-023168-cd7adns8	1303	34	through	through	IN
cord-023168-cd7adns8	1303	35	transmission	transmission	NN
cord-023168-cd7adns8	1303	36	of	of	IN
cord-023168-cd7adns8	1303	37	infectious	infectious	JJ
cord-023168-cd7adns8	1303	38	agents	agent	NNS
cord-023168-cd7adns8	1303	39	.	.	.
cord-023168-cd7adns8	1304	1	Clinicians	clinician	NNS
cord-023168-cd7adns8	1304	2	need	need	VBP
cord-023168-cd7adns8	1304	3	to	to	TO
cord-023168-cd7adns8	1304	4	understand	understand	VB
cord-023168-cd7adns8	1304	5	how	how	WRB
cord-023168-cd7adns8	1304	6	blood	blood	NN
cord-023168-cd7adns8	1304	7	is	be	VBZ
cord-023168-cd7adns8	1304	8	acquired	acquire	VBN
cord-023168-cd7adns8	1304	9	and	and	CC
cord-023168-cd7adns8	1304	10	its	-PRON-	PRP$
cord-023168-cd7adns8	1304	11	risks	risk	NNS
cord-023168-cd7adns8	1304	12	and	and	CC
cord-023168-cd7adns8	1304	13	benefits	benefit	NNS
cord-023168-cd7adns8	1304	14	,	,	,
cord-023168-cd7adns8	1304	15	and	and	CC
cord-023168-cd7adns8	1304	16	to	to	TO
cord-023168-cd7adns8	1304	17	use	use	VB
cord-023168-cd7adns8	1304	18	it	-PRON-	PRP
cord-023168-cd7adns8	1304	19	appropriately	appropriately	RB
cord-023168-cd7adns8	1304	20	.	.	.
cord-023168-cd7adns8	1305	1	Governments	government	NNS
cord-023168-cd7adns8	1305	2	and	and	CC
cord-023168-cd7adns8	1305	3	transfusion	transfusion	NN
cord-023168-cd7adns8	1305	4	services	service	NNS
cord-023168-cd7adns8	1305	5	need	need	VBP
cord-023168-cd7adns8	1305	6	to	to	TO
cord-023168-cd7adns8	1305	7	put	put	VB
cord-023168-cd7adns8	1305	8	measures	measure	NNS
cord-023168-cd7adns8	1305	9	in	in	IN
cord-023168-cd7adns8	1305	10	place	place	NN
cord-023168-cd7adns8	1305	11	to	to	TO
cord-023168-cd7adns8	1305	12	ensure	ensure	VB
cord-023168-cd7adns8	1305	13	that	that	DT
cord-023168-cd7adns8	1305	14	blood	blood	NN
cord-023168-cd7adns8	1305	15	is	be	VBZ
cord-023168-cd7adns8	1305	16	safe	safe	JJ
cord-023168-cd7adns8	1305	17	for	for	IN
cord-023168-cd7adns8	1305	18	transfusion	transfusion	NN
cord-023168-cd7adns8	1305	19	and	and	CC
cord-023168-cd7adns8	1305	20	that	that	IN
cord-023168-cd7adns8	1305	21	it	-PRON-	PRP
cord-023168-cd7adns8	1305	22	reaches	reach	VBZ
cord-023168-cd7adns8	1305	23	those	those	DT
cord-023168-cd7adns8	1305	24	who	who	WP
cord-023168-cd7adns8	1305	25	need	need	VBP
cord-023168-cd7adns8	1305	26	it	-PRON-	PRP
cord-023168-cd7adns8	1305	27	in	in	IN
cord-023168-cd7adns8	1305	28	a	a	DT
cord-023168-cd7adns8	1305	29	timely	timely	JJ
cord-023168-cd7adns8	1305	30	manner	manner	NN
cord-023168-cd7adns8	1305	31	.	.	.
cord-023168-cd7adns8	1306	1	Only	only	RB
cord-023168-cd7adns8	1306	2	16	16	CD
cord-023168-cd7adns8	1306	3	%	%	NN
cord-023168-cd7adns8	1306	4	of	of	IN
cord-023168-cd7adns8	1306	5	member	member	NN
cord-023168-cd7adns8	1306	6	states	state	NNS
cord-023168-cd7adns8	1306	7	meet	meet	VBP
cord-023168-cd7adns8	1306	8	all	all	PDT
cord-023168-cd7adns8	1306	9	the	the	DT
cord-023168-cd7adns8	1306	10	World	World	NNP
cord-023168-cd7adns8	1306	11	Health	Health	NNP
cord-023168-cd7adns8	1306	12	Organization	Organization	NNP
cord-023168-cd7adns8	1306	13	's	's	POS
cord-023168-cd7adns8	1306	14	(	(	-LRB-
cord-023168-cd7adns8	1306	15	WHO	who	WP
cord-023168-cd7adns8	1306	16	)	)	-RRB-
cord-023168-cd7adns8	1306	17	recommendations	recommendation	NNS
cord-023168-cd7adns8	1306	18	for	for	IN
cord-023168-cd7adns8	1306	19	a	a	DT
cord-023168-cd7adns8	1306	20	national	national	JJ
cord-023168-cd7adns8	1306	21	quality	quality	NN
cord-023168-cd7adns8	1306	22	blood	blood	NN
cord-023168-cd7adns8	1306	23	transfusion	transfusion	NN
cord-023168-cd7adns8	1306	24	system	system	NN
cord-023168-cd7adns8	1306	25	.	.	.
cord-023168-cd7adns8	1307	1	331	331	CD
cord-023168-cd7adns8	1308	1	At	at	IN
cord-023168-cd7adns8	1308	2	the	the	DT
cord-023168-cd7adns8	1308	3	national	national	JJ
cord-023168-cd7adns8	1308	4	level	level	NN
cord-023168-cd7adns8	1308	5	the	the	DT
cord-023168-cd7adns8	1308	6	transfusion	transfusion	NN
cord-023168-cd7adns8	1308	7	service	service	NN
cord-023168-cd7adns8	1308	8	should	should	MD
cord-023168-cd7adns8	1308	9	have	have	VB
cord-023168-cd7adns8	1308	10	a	a	DT
cord-023168-cd7adns8	1308	11	director	director	NN
cord-023168-cd7adns8	1308	12	,	,	,
cord-023168-cd7adns8	1308	13	an	an	DT
cord-023168-cd7adns8	1308	14	advisory	advisory	JJ
cord-023168-cd7adns8	1308	15	committee	committee	NN
cord-023168-cd7adns8	1308	16	and	and	CC
cord-023168-cd7adns8	1308	17	clear	clear	JJ
cord-023168-cd7adns8	1308	18	transfusion	transfusion	NN
cord-023168-cd7adns8	1308	19	policies	policy	NNS
cord-023168-cd7adns8	1308	20	and	and	CC
cord-023168-cd7adns8	1308	21	strategies	strategy	NNS
cord-023168-cd7adns8	1308	22	(	(	-LRB-
cord-023168-cd7adns8	1308	23	Table	table	NN
cord-023168-cd7adns8	1308	24	65	65	CD
cord-023168-cd7adns8	1308	25	.12	.12	CD
cord-023168-cd7adns8	1308	26	)	)	-RRB-
cord-023168-cd7adns8	1308	27	.	.	.
cord-023168-cd7adns8	1309	1	331	331	CD
cord-023168-cd7adns8	1309	2	WHO	who	WP
cord-023168-cd7adns8	1309	3	recommend	recommend	VBP
cord-023168-cd7adns8	1309	4	standardization	standardization	NN
cord-023168-cd7adns8	1309	5	of	of	IN
cord-023168-cd7adns8	1309	6	blood	blood	NN
cord-023168-cd7adns8	1309	7	collection	collection	NN
cord-023168-cd7adns8	1309	8	,	,	,
cord-023168-cd7adns8	1309	9	testing	testing	NN
cord-023168-cd7adns8	1309	10	and	and	CC
cord-023168-cd7adns8	1309	11	distribution	distribution	NN
cord-023168-cd7adns8	1309	12	.	.	.
cord-023168-cd7adns8	1310	1	Although	although	IN
cord-023168-cd7adns8	1310	2	centralization	centralization	NN
cord-023168-cd7adns8	1310	3	of	of	IN
cord-023168-cd7adns8	1310	4	these	these	DT
cord-023168-cd7adns8	1310	5	services	service	NNS
cord-023168-cd7adns8	1310	6	may	may	MD
cord-023168-cd7adns8	1310	7	offer	offer	VB
cord-023168-cd7adns8	1310	8	the	the	DT
cord-023168-cd7adns8	1310	9	best	good	JJS
cord-023168-cd7adns8	1310	10	guarantee	guarantee	NN
cord-023168-cd7adns8	1310	11	of	of	IN
cord-023168-cd7adns8	1310	12	quality	quality	NN
cord-023168-cd7adns8	1310	13	,	,	,
cord-023168-cd7adns8	1310	14	it	-PRON-	PRP
cord-023168-cd7adns8	1310	15	is	be	VBZ
cord-023168-cd7adns8	1310	16	often	often	RB
cord-023168-cd7adns8	1310	17	not	not	RB
cord-023168-cd7adns8	1310	18	practical	practical	JJ
cord-023168-cd7adns8	1310	19	in	in	IN
cord-023168-cd7adns8	1310	20	countries	country	NNS
cord-023168-cd7adns8	1310	21	with	with	IN
cord-023168-cd7adns8	1310	22	poorly	poorly	RB
cord-023168-cd7adns8	1310	23	developed	develop	VBN
cord-023168-cd7adns8	1310	24	communications	communication	NNS
cord-023168-cd7adns8	1310	25	and	and	CC
cord-023168-cd7adns8	1310	26	transport	transport	NN
cord-023168-cd7adns8	1310	27	infrastructure	infrastructure	NN
cord-023168-cd7adns8	1310	28	.	.	.
cord-023168-cd7adns8	1311	1	Two	two	CD
cord-023168-cd7adns8	1311	2	systems	system	NNS
cord-023168-cd7adns8	1311	3	,	,	,
cord-023168-cd7adns8	1311	4	centralized	centralized	JJ
cord-023168-cd7adns8	1311	5	and	and	CC
cord-023168-cd7adns8	1311	6	hospital	hospital	NN
cord-023168-cd7adns8	1311	7	-	-	HYPH
cord-023168-cd7adns8	1311	8	based	base	VBN
cord-023168-cd7adns8	1311	9	,	,	,
cord-023168-cd7adns8	1311	10	exist	exist	VBP
cord-023168-cd7adns8	1311	11	in	in	IN
cord-023168-cd7adns8	1311	12	lowincome	lowincome	NNP
cord-023168-cd7adns8	1311	13	countries	country	NNS
cord-023168-cd7adns8	1311	14	for	for	IN
cord-023168-cd7adns8	1311	15	managing	manage	VBG
cord-023168-cd7adns8	1311	16	blood	blood	NN
cord-023168-cd7adns8	1311	17	supply	supply	NN
cord-023168-cd7adns8	1311	18	.	.	.
cord-023168-cd7adns8	1312	1	In	in	IN
cord-023168-cd7adns8	1312	2	the	the	DT
cord-023168-cd7adns8	1312	3	centralized	centralized	JJ
cord-023168-cd7adns8	1312	4	system	system	NN
cord-023168-cd7adns8	1312	5	,	,	,
cord-023168-cd7adns8	1312	6	voluntary	voluntary	JJ
cord-023168-cd7adns8	1312	7	blood	blood	NN
cord-023168-cd7adns8	1312	8	donors	donor	NNS
cord-023168-cd7adns8	1312	9	are	be	VBP
cord-023168-cd7adns8	1312	10	recruited	recruit	VBN
cord-023168-cd7adns8	1312	11	,	,	,
cord-023168-cd7adns8	1312	12	screened	screen	VBN
cord-023168-cd7adns8	1312	13	and	and	CC
cord-023168-cd7adns8	1312	14	bled	bleed	VBN
cord-023168-cd7adns8	1312	15	by	by	IN
cord-023168-cd7adns8	1312	16	regional	regional	JJ
cord-023168-cd7adns8	1312	17	centres	centre	NNS
cord-023168-cd7adns8	1312	18	and	and	CC
cord-023168-cd7adns8	1312	19	the	the	DT
cord-023168-cd7adns8	1312	20	blood	blood	NN
cord-023168-cd7adns8	1312	21	collected	collect	VBN
cord-023168-cd7adns8	1312	22	is	be	VBZ
cord-023168-cd7adns8	1312	23	distributed	distribute	VBN
cord-023168-cd7adns8	1312	24	to	to	IN
cord-023168-cd7adns8	1312	25	peripheral	peripheral	JJ
cord-023168-cd7adns8	1312	26	hospitals	hospital	NNS
cord-023168-cd7adns8	1312	27	.	.	.
cord-023168-cd7adns8	1313	1	Hospital	hospital	NN
cord-023168-cd7adns8	1313	2	-	-	HYPH
cord-023168-cd7adns8	1313	3	based	base	VBN
cord-023168-cd7adns8	1313	4	systems	system	NNS
cord-023168-cd7adns8	1313	5	are	be	VBP
cord-023168-cd7adns8	1313	6	the	the	DT
cord-023168-cd7adns8	1313	7	predominant	predominant	JJ
cord-023168-cd7adns8	1313	8	source	source	NN
cord-023168-cd7adns8	1313	9	of	of	IN
cord-023168-cd7adns8	1313	10	blood	blood	NN
cord-023168-cd7adns8	1313	11	across	across	IN
cord-023168-cd7adns8	1313	12	sub	sub	JJ
cord-023168-cd7adns8	1313	13	-	-	JJ
cord-023168-cd7adns8	1313	14	Saharan	saharan	JJ
cord-023168-cd7adns8	1313	15	Africa	Africa	NNP
cord-023168-cd7adns8	1313	16	.	.	.
cord-023168-cd7adns8	1314	1	Hospital	hospital	NN
cord-023168-cd7adns8	1314	2	-	-	HYPH
cord-023168-cd7adns8	1314	3	based	base	VBN
cord-023168-cd7adns8	1314	4	systems	system	NNS
cord-023168-cd7adns8	1314	5	obtain	obtain	VBP
cord-023168-cd7adns8	1314	6	blood	blood	NN
cord-023168-cd7adns8	1314	7	predominantly	predominantly	RB
cord-023168-cd7adns8	1314	8	from	from	IN
cord-023168-cd7adns8	1314	9	relatives	relative	NNS
cord-023168-cd7adns8	1314	10	of	of	IN
cord-023168-cd7adns8	1314	11	patients	patient	NNS
cord-023168-cd7adns8	1314	12	,	,	,
cord-023168-cd7adns8	1314	13	and	and	CC
cord-023168-cd7adns8	1314	14	blood	blood	NN
cord-023168-cd7adns8	1314	15	is	be	VBZ
cord-023168-cd7adns8	1314	16	screened	screen	VBN
cord-023168-cd7adns8	1314	17	and	and	CC
cord-023168-cd7adns8	1314	18	used	use	VBN
cord-023168-cd7adns8	1314	19	within	within	IN
cord-023168-cd7adns8	1314	20	the	the	DT
cord-023168-cd7adns8	1314	21	local	local	JJ
cord-023168-cd7adns8	1314	22	vicinity	vicinity	NN
cord-023168-cd7adns8	1314	23	.	.	.
cord-023168-cd7adns8	1315	1	332	332	CD
cord-023168-cd7adns8	1315	2	Blood	blood	NN
cord-023168-cd7adns8	1315	3	from	from	IN
cord-023168-cd7adns8	1315	4	the	the	DT
cord-023168-cd7adns8	1315	5	centralized	centralized	JJ
cord-023168-cd7adns8	1315	6	system	system	NN
cord-023168-cd7adns8	1315	7	costs	cost	VBZ
cord-023168-cd7adns8	1315	8	at	at	RB
cord-023168-cd7adns8	1315	9	least	least	RBS
cord-023168-cd7adns8	1315	10	three	three	CD
cord-023168-cd7adns8	1315	11	times	time	NNS
cord-023168-cd7adns8	1315	12	as	as	RB
cord-023168-cd7adns8	1315	13	much	much	JJ
cord-023168-cd7adns8	1315	14	per	per	IN
cord-023168-cd7adns8	1315	15	unit	unit	NN
cord-023168-cd7adns8	1315	16	as	as	IN
cord-023168-cd7adns8	1315	17	that	that	IN
cord-023168-cd7adns8	1315	18	from	from	IN
cord-023168-cd7adns8	1315	19	a	a	DT
cord-023168-cd7adns8	1315	20	hospital	hospital	NN
cord-023168-cd7adns8	1315	21	-	-	HYPH
cord-023168-cd7adns8	1315	22	based	base	VBN
cord-023168-cd7adns8	1315	23	system	system	NN
cord-023168-cd7adns8	1315	24	.	.	.
cord-023168-cd7adns8	1316	1	333	333	CD
cord-023168-cd7adns8	1317	1	Although	although	IN
cord-023168-cd7adns8	1317	2	centralized	centralized	JJ
cord-023168-cd7adns8	1317	3	systems	system	NNS
cord-023168-cd7adns8	1317	4	can	can	MD
cord-023168-cd7adns8	1317	5	save	save	VB
cord-023168-cd7adns8	1317	6	costs	cost	NNS
cord-023168-cd7adns8	1317	7	through	through	IN
cord-023168-cd7adns8	1317	8	batching	batching	NN
cord-023168-cd7adns8	1317	9	and	and	CC
cord-023168-cd7adns8	1317	10	bulk	bulk	JJ
cord-023168-cd7adns8	1317	11	purchasing	purchasing	NN
cord-023168-cd7adns8	1317	12	,	,	,
cord-023168-cd7adns8	1317	13	the	the	DT
cord-023168-cd7adns8	1317	14	quality	quality	NN
cord-023168-cd7adns8	1317	15	assurance	assurance	NN
cord-023168-cd7adns8	1317	16	processes	process	NNS
cord-023168-cd7adns8	1317	17	and	and	CC
cord-023168-cd7adns8	1317	18	donor	donor	NN
cord-023168-cd7adns8	1317	19	recruitment	recruitment	NN
cord-023168-cd7adns8	1317	20	components	component	NNS
cord-023168-cd7adns8	1317	21	are	be	VBP
cord-023168-cd7adns8	1317	22	expensive	expensive	JJ
cord-023168-cd7adns8	1317	23	and	and	CC
cord-023168-cd7adns8	1317	24	difficult	difficult	JJ
cord-023168-cd7adns8	1317	25	to	to	TO
cord-023168-cd7adns8	1317	26	maintain	maintain	VB
cord-023168-cd7adns8	1317	27	without	without	IN
cord-023168-cd7adns8	1317	28	dependence	dependence	NN
cord-023168-cd7adns8	1317	29	on	on	IN
cord-023168-cd7adns8	1317	30	external	external	JJ
cord-023168-cd7adns8	1317	31	funds	fund	NNS
cord-023168-cd7adns8	1317	32	.	.	.
cord-023168-cd7adns8	1318	1	In	in	IN
cord-023168-cd7adns8	1318	2	hospital	hospital	NN
cord-023168-cd7adns8	1318	3	-	-	HYPH
cord-023168-cd7adns8	1318	4	based	base	VBN
cord-023168-cd7adns8	1318	5	transfusion	transfusion	NN
cord-023168-cd7adns8	1318	6	services	service	NNS
cord-023168-cd7adns8	1318	7	,	,	,
cord-023168-cd7adns8	1318	8	testing	test	VBG
cord-023168-cd7adns8	1318	9	quality	quality	NN
cord-023168-cd7adns8	1318	10	is	be	VBZ
cord-023168-cd7adns8	1318	11	variable	variable	JJ
cord-023168-cd7adns8	1318	12	and	and	CC
cord-023168-cd7adns8	1318	13	the	the	DT
cord-023168-cd7adns8	1318	14	families	family	NNS
cord-023168-cd7adns8	1318	15	of	of	IN
cord-023168-cd7adns8	1318	16	patients	patient	NNS
cord-023168-cd7adns8	1318	17	bear	bear	VBP
cord-023168-cd7adns8	1318	18	the	the	DT
cord-023168-cd7adns8	1318	19	cost	cost	NN
cord-023168-cd7adns8	1318	20	of	of	IN
cord-023168-cd7adns8	1318	21	finding	find	VBG
cord-023168-cd7adns8	1318	22	blood	blood	NN
cord-023168-cd7adns8	1318	23	donors	donor	NNS
cord-023168-cd7adns8	1318	24	.	.	.
cord-023168-cd7adns8	1319	1	The	the	DT
cord-023168-cd7adns8	1319	2	vast	vast	JJ
cord-023168-cd7adns8	1319	3	majority	majority	NN
cord-023168-cd7adns8	1319	4	of	of	IN
cord-023168-cd7adns8	1319	5	blood	blood	NN
cord-023168-cd7adns8	1319	6	in	in	IN
cord-023168-cd7adns8	1319	7	low	low	JJ
cord-023168-cd7adns8	1319	8	-	-	HYPH
cord-023168-cd7adns8	1319	9	income	income	NN
cord-023168-cd7adns8	1319	10	countries	country	NNS
cord-023168-cd7adns8	1319	11	is	be	VBZ
cord-023168-cd7adns8	1319	12	transfused	transfuse	VBN
cord-023168-cd7adns8	1319	13	as	as	IN
cord-023168-cd7adns8	1319	14	whole	whole	JJ
cord-023168-cd7adns8	1319	15	blood	blood	NN
cord-023168-cd7adns8	1319	16	.	.	.
cord-023168-cd7adns8	1320	1	In	in	IN
cord-023168-cd7adns8	1320	2	high	high	JJ
cord-023168-cd7adns8	1320	3	-	-	HYPH
cord-023168-cd7adns8	1320	4	income	income	NN
cord-023168-cd7adns8	1320	5	countries	country	NNS
cord-023168-cd7adns8	1320	6	it	-PRON-	PRP
cord-023168-cd7adns8	1320	7	is	be	VBZ
cord-023168-cd7adns8	1320	8	standard	standard	JJ
cord-023168-cd7adns8	1320	9	practice	practice	NN
cord-023168-cd7adns8	1320	10	to	to	TO
cord-023168-cd7adns8	1320	11	optimize	optimize	VB
cord-023168-cd7adns8	1320	12	the	the	DT
cord-023168-cd7adns8	1320	13	use	use	NN
cord-023168-cd7adns8	1320	14	of	of	IN
cord-023168-cd7adns8	1320	15	each	each	DT
cord-023168-cd7adns8	1320	16	donation	donation	NN
cord-023168-cd7adns8	1320	17	of	of	IN
cord-023168-cd7adns8	1320	18	blood	blood	NN
cord-023168-cd7adns8	1320	19	by	by	IN
cord-023168-cd7adns8	1320	20	separating	separate	VBG
cord-023168-cd7adns8	1320	21	it	-PRON-	PRP
cord-023168-cd7adns8	1320	22	into	into	IN
cord-023168-cd7adns8	1320	23	individual	individual	JJ
cord-023168-cd7adns8	1320	24	components	component	NNS
cord-023168-cd7adns8	1320	25	but	but	CC
cord-023168-cd7adns8	1320	26	whether	whether	IN
cord-023168-cd7adns8	1320	27	this	this	DT
cord-023168-cd7adns8	1320	28	approach	approach	NN
cord-023168-cd7adns8	1320	29	is	be	VBZ
cord-023168-cd7adns8	1320	30	cost	cost	NN
cord-023168-cd7adns8	1320	31	-	-	HYPH
cord-023168-cd7adns8	1320	32	effective	effective	JJ
cord-023168-cd7adns8	1320	33	in	in	IN
cord-023168-cd7adns8	1320	34	low	low	JJ
cord-023168-cd7adns8	1320	35	-	-	HYPH
cord-023168-cd7adns8	1320	36	income	income	NN
cord-023168-cd7adns8	1320	37	countries	country	NNS
cord-023168-cd7adns8	1320	38	,	,	,
cord-023168-cd7adns8	1320	39	where	where	WRB
cord-023168-cd7adns8	1320	40	indications	indication	NNS
cord-023168-cd7adns8	1320	41	for	for	IN
cord-023168-cd7adns8	1320	42	transfusion	transfusion	NN
cord-023168-cd7adns8	1320	43	are	be	VBP
cord-023168-cd7adns8	1320	44	different	different	JJ
cord-023168-cd7adns8	1320	45	,	,	,
cord-023168-cd7adns8	1320	46	is	be	VBZ
cord-023168-cd7adns8	1320	47	not	not	RB
cord-023168-cd7adns8	1320	48	known	know	VBN
cord-023168-cd7adns8	1320	49	.	.	.
cord-023168-cd7adns8	1321	1	These	these	DT
cord-023168-cd7adns8	1321	2	components	component	NNS
cord-023168-cd7adns8	1321	3	,	,	,
cord-023168-cd7adns8	1321	4	which	which	WDT
cord-023168-cd7adns8	1321	5	may	may	MD
cord-023168-cd7adns8	1321	6	include	include	VB
cord-023168-cd7adns8	1321	7	plasma	plasma	NN
cord-023168-cd7adns8	1321	8	,	,	,
cord-023168-cd7adns8	1321	9	platelets	platelet	NNS
cord-023168-cd7adns8	1321	10	and	and	CC
cord-023168-cd7adns8	1321	11	cryoprecipitate	cryoprecipitate	NNP
cord-023168-cd7adns8	1321	12	,	,	,
cord-023168-cd7adns8	1321	13	are	be	VBP
cord-023168-cd7adns8	1321	14	prepared	prepare	VBN
cord-023168-cd7adns8	1321	15	by	by	IN
cord-023168-cd7adns8	1321	16	centrifugation	centrifugation	NN
cord-023168-cd7adns8	1321	17	using	use	VBG
cord-023168-cd7adns8	1321	18	a	a	DT
cord-023168-cd7adns8	1321	19	closed	closed	JJ
cord-023168-cd7adns8	1321	20	,	,	,
cord-023168-cd7adns8	1321	21	sterile	sterile	JJ
cord-023168-cd7adns8	1321	22	system	system	NN
cord-023168-cd7adns8	1321	23	and	and	CC
cord-023168-cd7adns8	1321	24	each	each	DT
cord-023168-cd7adns8	1321	25	component	component	NN
cord-023168-cd7adns8	1321	26	has	have	VBZ
cord-023168-cd7adns8	1321	27	different	different	JJ
cord-023168-cd7adns8	1321	28	storage	storage	NN
cord-023168-cd7adns8	1321	29	requirements	requirement	NNS
cord-023168-cd7adns8	1321	30	.	.	.
cord-023168-cd7adns8	1322	1	Plasma	plasma	NN
cord-023168-cd7adns8	1322	2	and	and	CC
cord-023168-cd7adns8	1322	3	cryoprecipitate	cryoprecipitate	NNP
cord-023168-cd7adns8	1322	4	are	be	VBP
cord-023168-cd7adns8	1322	5	kept	keep	VBN
cord-023168-cd7adns8	1322	6	frozen	frozen	JJ
cord-023168-cd7adns8	1322	7	,	,	,
cord-023168-cd7adns8	1322	8	red	red	JJ
cord-023168-cd7adns8	1322	9	cells	cell	NNS
cord-023168-cd7adns8	1322	10	are	be	VBP
cord-023168-cd7adns8	1322	11	stored	store	VBN
cord-023168-cd7adns8	1322	12	at	at	IN
cord-023168-cd7adns8	1322	13	1	1	CD
cord-023168-cd7adns8	1322	14	-	-	SYM
cord-023168-cd7adns8	1322	15	5	5	CD
cord-023168-cd7adns8	1322	16	°	°	NN
cord-023168-cd7adns8	1322	17	C	c	NN
cord-023168-cd7adns8	1322	18	,	,	,
cord-023168-cd7adns8	1322	19	and	and	CC
cord-023168-cd7adns8	1322	20	platelets	platelet	NNS
cord-023168-cd7adns8	1322	21	at	at	IN
cord-023168-cd7adns8	1322	22	18	18	CD
cord-023168-cd7adns8	1322	23	-	-	SYM
cord-023168-cd7adns8	1322	24	22	22	CD
cord-023168-cd7adns8	1322	25	°	°	NN
cord-023168-cd7adns8	1322	26	C	c	NN
cord-023168-cd7adns8	1322	27	with	with	IN
cord-023168-cd7adns8	1322	28	constant	constant	JJ
cord-023168-cd7adns8	1322	29	agitation	agitation	NN
cord-023168-cd7adns8	1322	30	.	.	.
cord-023168-cd7adns8	1323	1	Recent	recent	JJ
cord-023168-cd7adns8	1323	2	evidence	evidence	NN
cord-023168-cd7adns8	1323	3	suggests	suggest	VBZ
cord-023168-cd7adns8	1323	4	that	that	IN
cord-023168-cd7adns8	1323	5	warm	warm	JJ
cord-023168-cd7adns8	1323	6	,	,	,
cord-023168-cd7adns8	1323	7	fresh	fresh	JJ
cord-023168-cd7adns8	1323	8	,	,	,
cord-023168-cd7adns8	1323	9	whole	whole	JJ
cord-023168-cd7adns8	1323	10	blood	blood	NN
cord-023168-cd7adns8	1323	11	may	may	MD
cord-023168-cd7adns8	1323	12	be	be	VB
cord-023168-cd7adns8	1323	13	better	well	JJR
cord-023168-cd7adns8	1323	14	than	than	IN
cord-023168-cd7adns8	1323	15	component	component	NN
cord-023168-cd7adns8	1323	16	therapy	therapy	NN
cord-023168-cd7adns8	1323	17	for	for	IN
cord-023168-cd7adns8	1323	18	resuscitation	resuscitation	NN
cord-023168-cd7adns8	1323	19	of	of	IN
cord-023168-cd7adns8	1323	20	acidotic	acidotic	JJ
cord-023168-cd7adns8	1323	21	,	,	,
cord-023168-cd7adns8	1323	22	hypothermic	hypothermic	JJ
cord-023168-cd7adns8	1323	23	and	and	CC
cord-023168-cd7adns8	1323	24	coagulopathic	coagulopathic	JJ
cord-023168-cd7adns8	1323	25	trauma	trauma	NN
cord-023168-cd7adns8	1323	26	patients	patient	NNS
cord-023168-cd7adns8	1323	27	334	334	CD
cord-023168-cd7adns8	1323	28	and	and	CC
cord-023168-cd7adns8	1323	29	for	for	IN
cord-023168-cd7adns8	1323	30	patients	patient	NNS
cord-023168-cd7adns8	1323	31	needing	need	VBG
cord-023168-cd7adns8	1323	32	massive	massive	JJ
cord-023168-cd7adns8	1323	33	transfusions	transfusion	NNS
cord-023168-cd7adns8	1323	34	.	.	.
cord-023168-cd7adns8	1324	1	335	335	CD
cord-023168-cd7adns8	1324	2	 	 	_SP
cord-023168-cd7adns8	1325	1	Many	many	JJ
cord-023168-cd7adns8	1325	2	infections	infection	NNS
cord-023168-cd7adns8	1325	3	can	can	MD
cord-023168-cd7adns8	1325	4	be	be	VB
cord-023168-cd7adns8	1325	5	transmitted	transmit	VBN
cord-023168-cd7adns8	1325	6	through	through	IN
cord-023168-cd7adns8	1325	7	blood	blood	NN
cord-023168-cd7adns8	1325	8	transfusions	transfusion	NNS
cord-023168-cd7adns8	1325	9	and	and	CC
cord-023168-cd7adns8	1325	10	transfusion	transfusion	NN
cord-023168-cd7adns8	1325	11	of	of	IN
cord-023168-cd7adns8	1325	12	infected	infected	JJ
cord-023168-cd7adns8	1325	13	blood	blood	NN
cord-023168-cd7adns8	1325	14	causes	cause	VBZ
cord-023168-cd7adns8	1325	15	morbidity	morbidity	NN
cord-023168-cd7adns8	1325	16	and	and	CC
cord-023168-cd7adns8	1325	17	mortality	mortality	NN
cord-023168-cd7adns8	1325	18	in	in	IN
cord-023168-cd7adns8	1325	19	the	the	DT
cord-023168-cd7adns8	1325	20	recipients	recipient	NNS
cord-023168-cd7adns8	1325	21	,	,	,
cord-023168-cd7adns8	1325	22	and	and	CC
cord-023168-cd7adns8	1325	23	has	have	VBZ
cord-023168-cd7adns8	1325	24	an	an	DT
cord-023168-cd7adns8	1325	25	economic	economic	JJ
cord-023168-cd7adns8	1325	26	and	and	CC
cord-023168-cd7adns8	1325	27	emotional	emotional	JJ
cord-023168-cd7adns8	1325	28	impact	impact	NN
cord-023168-cd7adns8	1325	29	on	on	IN
cord-023168-cd7adns8	1325	30	their	-PRON-	PRP$
cord-023168-cd7adns8	1325	31	families	family	NNS
cord-023168-cd7adns8	1325	32	and	and	CC
cord-023168-cd7adns8	1325	33	communities	community	NNS
cord-023168-cd7adns8	1325	34	.	.	.
cord-023168-cd7adns8	1326	1	Those	those	DT
cord-023168-cd7adns8	1326	2	who	who	WP
cord-023168-cd7adns8	1326	3	become	become	VBP
cord-023168-cd7adns8	1326	4	infected	infect	VBN
cord-023168-cd7adns8	1326	5	through	through	IN
cord-023168-cd7adns8	1326	6	blood	blood	NN
cord-023168-cd7adns8	1326	7	transfusion	transfusion	NN
cord-023168-cd7adns8	1326	8	are	be	VBP
cord-023168-cd7adns8	1326	9	infectious	infectious	JJ
cord-023168-cd7adns8	1326	10	to	to	IN
cord-023168-cd7adns8	1326	11	others	other	NNS
cord-023168-cd7adns8	1326	12	and	and	CC
cord-023168-cd7adns8	1326	13	contribute	contribute	VB
cord-023168-cd7adns8	1326	14	to	to	IN
cord-023168-cd7adns8	1326	15	the	the	DT
cord-023168-cd7adns8	1326	16	spread	spread	NN
cord-023168-cd7adns8	1326	17	of	of	IN
cord-023168-cd7adns8	1326	18	disease	disease	NN
cord-023168-cd7adns8	1326	19	thereby	thereby	RB
cord-023168-cd7adns8	1326	20	increasing	increase	VBG
cord-023168-cd7adns8	1326	21	the	the	DT
cord-023168-cd7adns8	1326	22	burden	burden	NN
cord-023168-cd7adns8	1326	23	on	on	IN
cord-023168-cd7adns8	1326	24	health	health	NN
cord-023168-cd7adns8	1326	25	services	service	NNS
cord-023168-cd7adns8	1326	26	and	and	CC
cord-023168-cd7adns8	1326	27	reducing	reduce	VBG
cord-023168-cd7adns8	1326	28	productive	productive	JJ
cord-023168-cd7adns8	1326	29	labour	labour	NN
cord-023168-cd7adns8	1326	30	.	.	.
cord-023168-cd7adns8	1327	1	Strategies	strategy	NNS
cord-023168-cd7adns8	1327	2	for	for	IN
cord-023168-cd7adns8	1327	3	recruiting	recruit	VBG
cord-023168-cd7adns8	1327	4	blood	blood	NN
cord-023168-cd7adns8	1327	5	donors	donor	NNS
cord-023168-cd7adns8	1327	6	have	have	VBP
cord-023168-cd7adns8	1327	7	to	to	TO
cord-023168-cd7adns8	1327	8	provide	provide	VB
cord-023168-cd7adns8	1327	9	blood	blood	NN
cord-023168-cd7adns8	1327	10	for	for	IN
cord-023168-cd7adns8	1327	11	all	all	DT
cord-023168-cd7adns8	1327	12	who	who	WP
cord-023168-cd7adns8	1327	13	need	need	VBP
cord-023168-cd7adns8	1327	14	it	-PRON-	PRP
cord-023168-cd7adns8	1327	15	in	in	IN
cord-023168-cd7adns8	1327	16	a	a	DT
cord-023168-cd7adns8	1327	17	timely	timely	JJ
cord-023168-cd7adns8	1327	18	manner	manner	NN
cord-023168-cd7adns8	1327	19	while	while	IN
cord-023168-cd7adns8	1327	20	ensuring	ensure	VBG
cord-023168-cd7adns8	1327	21	that	that	IN
cord-023168-cd7adns8	1327	22	the	the	DT
cord-023168-cd7adns8	1327	23	blood	blood	NN
cord-023168-cd7adns8	1327	24	is	be	VBZ
cord-023168-cd7adns8	1327	25	as	as	RB
cord-023168-cd7adns8	1327	26	safe	safe	JJ
cord-023168-cd7adns8	1327	27	as	as	IN
cord-023168-cd7adns8	1327	28	possible	possible	JJ
cord-023168-cd7adns8	1327	29	.	.	.
cord-023168-cd7adns8	1328	1	The	the	DT
cord-023168-cd7adns8	1328	2	safest	safe	JJS
cord-023168-cd7adns8	1328	3	type	type	NN
cord-023168-cd7adns8	1328	4	of	of	IN
cord-023168-cd7adns8	1328	5	blood	blood	NN
cord-023168-cd7adns8	1328	6	donor	donor	NN
cord-023168-cd7adns8	1328	7	is	be	VBZ
cord-023168-cd7adns8	1328	8	one	one	CD
cord-023168-cd7adns8	1328	9	who	who	WP
cord-023168-cd7adns8	1328	10	donates	donate	VBZ
cord-023168-cd7adns8	1328	11	regularly	regularly	RB
cord-023168-cd7adns8	1328	12	(	(	-LRB-
cord-023168-cd7adns8	1328	13	i.e.	i.e.	FW
cord-023168-cd7adns8	1328	14	repeat	repeat	NN
cord-023168-cd7adns8	1328	15	donors	donor	NNS
cord-023168-cd7adns8	1328	16	)	)	-RRB-
cord-023168-cd7adns8	1328	17	.	.	.
cord-023168-cd7adns8	1329	1	WHO	who	WP
cord-023168-cd7adns8	1329	2	states	state	VBZ
cord-023168-cd7adns8	1329	3	that	that	IN
cord-023168-cd7adns8	1329	4	the	the	DT
cord-023168-cd7adns8	1329	5	safest	safe	JJS
cord-023168-cd7adns8	1329	6	source	source	NN
cord-023168-cd7adns8	1329	7	of	of	IN
cord-023168-cd7adns8	1329	8	blood	blood	NN
cord-023168-cd7adns8	1329	9	is	be	VBZ
cord-023168-cd7adns8	1329	10	altruistic	altruistic	JJ
cord-023168-cd7adns8	1329	11	,	,	,
cord-023168-cd7adns8	1329	12	voluntary	voluntary	JJ
cord-023168-cd7adns8	1329	13	,	,	,
cord-023168-cd7adns8	1329	14	unpaid	unpaid	JJ
cord-023168-cd7adns8	1329	15	donors	donor	NNS
cord-023168-cd7adns8	1329	16	.	.	.
cord-023168-cd7adns8	1330	1	Only	only	RB
cord-023168-cd7adns8	1330	2	32	32	CD
cord-023168-cd7adns8	1330	3	%	%	NN
cord-023168-cd7adns8	1330	4	of	of	IN
cord-023168-cd7adns8	1330	5	WHO	WHO	NNP
cord-023168-cd7adns8	1330	6	member	member	NN
cord-023168-cd7adns8	1330	7	states	state	NNS
cord-023168-cd7adns8	1330	8	report	report	VBP
cord-023168-cd7adns8	1330	9	having	have	VBG
cord-023168-cd7adns8	1330	10	at	at	RB
cord-023168-cd7adns8	1330	11	least	least	RBS
cord-023168-cd7adns8	1330	12	90	90	CD
cord-023168-cd7adns8	1330	13	%	%	NN
cord-023168-cd7adns8	1330	14	of	of	IN
cord-023168-cd7adns8	1330	15	their	-PRON-	PRP$
cord-023168-cd7adns8	1330	16	blood	blood	NN
cord-023168-cd7adns8	1330	17	supply	supply	NN
cord-023168-cd7adns8	1330	18	from	from	IN
cord-023168-cd7adns8	1330	19	voluntary	voluntary	JJ
cord-023168-cd7adns8	1330	20	donors	donor	NNS
cord-023168-cd7adns8	1330	21	,	,	,
cord-023168-cd7adns8	1330	22	and	and	CC
cord-023168-cd7adns8	1330	23	low	low	JJ
cord-023168-cd7adns8	1330	24	-	-	HYPH
cord-023168-cd7adns8	1330	25	income	income	NN
cord-023168-cd7adns8	1330	26	countries	country	NNS
cord-023168-cd7adns8	1330	27	have	have	VBP
cord-023168-cd7adns8	1330	28	not	not	RB
cord-023168-cd7adns8	1330	29	been	be	VBN
cord-023168-cd7adns8	1330	30	able	able	JJ
cord-023168-cd7adns8	1330	31	to	to	TO
cord-023168-cd7adns8	1330	32	increase	increase	VB
cord-023168-cd7adns8	1330	33	the	the	DT
cord-023168-cd7adns8	1330	34	recruitment	recruitment	NN
cord-023168-cd7adns8	1330	35	of	of	IN
cord-023168-cd7adns8	1330	36	voluntary	voluntary	JJ
cord-023168-cd7adns8	1330	37	donors	donor	NNS
cord-023168-cd7adns8	1330	38	for	for	IN
cord-023168-cd7adns8	1330	39	several	several	JJ
cord-023168-cd7adns8	1330	40	years	year	NNS
cord-023168-cd7adns8	1330	41	.	.	.
cord-023168-cd7adns8	1331	1	331	331	CD
cord-023168-cd7adns8	1331	2	Recent	recent	JJ
cord-023168-cd7adns8	1331	3	evidence	evidence	NN
cord-023168-cd7adns8	1331	4	from	from	IN
cord-023168-cd7adns8	1331	5	sub	sub	JJ
cord-023168-cd7adns8	1331	6	-	-	NNP
cord-023168-cd7adns8	1331	7	Saharan	Saharan	NNP
cord-023168-cd7adns8	1331	8	Africa	Africa	NNP
cord-023168-cd7adns8	1331	9	indicates	indicate	VBZ
cord-023168-cd7adns8	1331	10	that	that	IN
cord-023168-cd7adns8	1331	11	the	the	DT
cord-023168-cd7adns8	1331	12	focus	focus	NN
cord-023168-cd7adns8	1331	13	on	on	IN
cord-023168-cd7adns8	1331	14	voluntary	voluntary	JJ
cord-023168-cd7adns8	1331	15	donors	donor	NNS
cord-023168-cd7adns8	1331	16	may	may	MD
cord-023168-cd7adns8	1331	17	be	be	VB
cord-023168-cd7adns8	1331	18	misplaced	misplace	VBN
cord-023168-cd7adns8	1331	19	since	since	IN
cord-023168-cd7adns8	1331	20	first	first	JJ
cord-023168-cd7adns8	1331	21	-	-	HYPH
cord-023168-cd7adns8	1331	22	time	time	NN
cord-023168-cd7adns8	1331	23	voluntary	voluntary	JJ
cord-023168-cd7adns8	1331	24	donors	donor	NNS
cord-023168-cd7adns8	1331	25	have	have	VBP
cord-023168-cd7adns8	1331	26	a	a	DT
cord-023168-cd7adns8	1331	27	similar	similar	JJ
cord-023168-cd7adns8	1331	28	prevalence	prevalence	NN
cord-023168-cd7adns8	1331	29	of	of	IN
cord-023168-cd7adns8	1331	30	transfusion	transfusion	NN
cord-023168-cd7adns8	1331	31	-	-	HYPH
cord-023168-cd7adns8	1331	32	transmitted	transmit	VBN
cord-023168-cd7adns8	1331	33	infections	infection	NNS
cord-023168-cd7adns8	1331	34	as	as	IN
cord-023168-cd7adns8	1331	35	family	family	NN
cord-023168-cd7adns8	1331	36	replacement	replacement	NN
cord-023168-cd7adns8	1331	37	donors	donor	NNS
cord-023168-cd7adns8	1331	38	.	.	.
cord-023168-cd7adns8	1332	1	336	336	CD
cord-023168-cd7adns8	1333	1	In	in	IN
cord-023168-cd7adns8	1333	2	order	order	NN
cord-023168-cd7adns8	1333	3	to	to	TO
cord-023168-cd7adns8	1333	4	limit	limit	VB
cord-023168-cd7adns8	1333	5	blood	blood	NN
cord-023168-cd7adns8	1333	6	shortage	shortage	NN
cord-023168-cd7adns8	1333	7	and	and	CC
cord-023168-cd7adns8	1333	8	maintain	maintain	VB
cord-023168-cd7adns8	1333	9	constant	constant	JJ
cord-023168-cd7adns8	1333	10	blood	blood	NN
cord-023168-cd7adns8	1333	11	supply	supply	NN
cord-023168-cd7adns8	1333	12	in	in	IN
cord-023168-cd7adns8	1333	13	poorer	poor	JJR
cord-023168-cd7adns8	1333	14	countries	country	NNS
cord-023168-cd7adns8	1333	15	,	,	,
cord-023168-cd7adns8	1333	16	both	both	CC
cord-023168-cd7adns8	1333	17	voluntary	voluntary	JJ
cord-023168-cd7adns8	1333	18	and	and	CC
cord-023168-cd7adns8	1333	19	replacement	replacement	NN
cord-023168-cd7adns8	1333	20	donors	donor	NNS
cord-023168-cd7adns8	1333	21	should	should	MD
cord-023168-cd7adns8	1333	22	be	be	VB
cord-023168-cd7adns8	1333	23	accepted	accept	VBN
cord-023168-cd7adns8	1333	24	and	and	CC
cord-023168-cd7adns8	1333	25	encouraged	encourage	VBN
cord-023168-cd7adns8	1333	26	to	to	TO
cord-023168-cd7adns8	1333	27	donate	donate	VB
cord-023168-cd7adns8	1333	28	regularly	regularly	RB
cord-023168-cd7adns8	1333	29	.	.	.
cord-023168-cd7adns8	1334	1	Mechanisms	mechanism	NNS
cord-023168-cd7adns8	1334	2	to	to	TO
cord-023168-cd7adns8	1334	3	convert	convert	VB
cord-023168-cd7adns8	1334	4	family	family	NN
cord-023168-cd7adns8	1334	5	replacement	replacement	NN
cord-023168-cd7adns8	1334	6	donors	donor	NNS
cord-023168-cd7adns8	1334	7	into	into	IN
cord-023168-cd7adns8	1334	8	repeating	repeat	VBG
cord-023168-cd7adns8	1334	9	voluntary	voluntary	JJ
cord-023168-cd7adns8	1334	10	donors	donor	NNS
cord-023168-cd7adns8	1334	11	have	have	VBP
cord-023168-cd7adns8	1334	12	the	the	DT
cord-023168-cd7adns8	1334	13	potential	potential	NN
cord-023168-cd7adns8	1334	14	to	to	TO
cord-023168-cd7adns8	1334	15	significantly	significantly	RB
cord-023168-cd7adns8	1334	16	increase	increase	VB
cord-023168-cd7adns8	1334	17	blood	blood	NN
cord-023168-cd7adns8	1334	18	donations	donation	NNS
cord-023168-cd7adns8	1334	19	in	in	IN
cord-023168-cd7adns8	1334	20	Africa	Africa	NNP
cord-023168-cd7adns8	1334	21	.	.	.
cord-023168-cd7adns8	1335	1	Political	political	JJ
cord-023168-cd7adns8	1335	2	will	will	MD
cord-023168-cd7adns8	1335	3	and	and	CC
cord-023168-cd7adns8	1335	4	open	open	JJ
cord-023168-cd7adns8	1335	5	-	-	HYPH
cord-023168-cd7adns8	1335	6	mindedness	mindedness	NN
cord-023168-cd7adns8	1335	7	about	about	IN
cord-023168-cd7adns8	1335	8	ways	way	NNS
cord-023168-cd7adns8	1335	9	to	to	TO
cord-023168-cd7adns8	1335	10	improve	improve	VB
cord-023168-cd7adns8	1335	11	the	the	DT
cord-023168-cd7adns8	1335	12	supply	supply	NN
cord-023168-cd7adns8	1335	13	and	and	CC
cord-023168-cd7adns8	1335	14	safety	safety	NN
cord-023168-cd7adns8	1335	15	of	of	IN
cord-023168-cd7adns8	1335	16	blood	blood	NN
cord-023168-cd7adns8	1335	17	are	be	VBP
cord-023168-cd7adns8	1335	18	essential	essential	JJ
cord-023168-cd7adns8	1335	19	to	to	TO
cord-023168-cd7adns8	1335	20	promote	promote	VB
cord-023168-cd7adns8	1335	21	more	more	JJR
cord-023168-cd7adns8	1335	22	evidence	evidence	NN
cord-023168-cd7adns8	1335	23	-	-	HYPH
cord-023168-cd7adns8	1335	24	based	base	VBN
cord-023168-cd7adns8	1335	25	approaches	approach	NNS
cord-023168-cd7adns8	1335	26	to	to	IN
cord-023168-cd7adns8	1335	27	blood	blood	NN
cord-023168-cd7adns8	1335	28	transfusion	transfusion	NN
cord-023168-cd7adns8	1335	29	practice	practice	NN
cord-023168-cd7adns8	1335	30	in	in	IN
cord-023168-cd7adns8	1335	31	poorer	poor	JJR
cord-023168-cd7adns8	1335	32	countries	country	NNS
cord-023168-cd7adns8	1335	33	.	.	.
cord-023168-cd7adns8	1336	1	337	337	CD
cord-023168-cd7adns8	1336	2	 	 	_SP
cord-023168-cd7adns8	1336	3	Supporting	support	VBG
cord-023168-cd7adns8	1336	4	Strategy	Strategy	NNP
cord-023168-cd7adns8	1336	5	 	 	_SP
cord-023168-cd7adns8	1337	1	In	in	IN
cord-023168-cd7adns8	1337	2	wealthy	wealthy	JJ
cord-023168-cd7adns8	1337	3	countries	country	NNS
cord-023168-cd7adns8	1337	4	,	,	,
cord-023168-cd7adns8	1337	5	the	the	DT
cord-023168-cd7adns8	1337	6	majority	majority	NN
cord-023168-cd7adns8	1337	7	of	of	IN
cord-023168-cd7adns8	1337	8	transfusions	transfusion	NNS
cord-023168-cd7adns8	1337	9	are	be	VBP
cord-023168-cd7adns8	1337	10	carried	carry	VBN
cord-023168-cd7adns8	1337	11	out	out	RP
cord-023168-cd7adns8	1337	12	electively	electively	RB
cord-023168-cd7adns8	1337	13	.	.	.
cord-023168-cd7adns8	1338	1	By	by	IN
cord-023168-cd7adns8	1338	2	contrast	contrast	NN
cord-023168-cd7adns8	1338	3	,	,	,
cord-023168-cd7adns8	1338	4	in	in	IN
cord-023168-cd7adns8	1338	5	poorer	poor	JJR
cord-023168-cd7adns8	1338	6	countries	country	NNS
cord-023168-cd7adns8	1338	7	,	,	,
cord-023168-cd7adns8	1338	8	and	and	CC
cord-023168-cd7adns8	1338	9	particularly	particularly	RB
cord-023168-cd7adns8	1338	10	those	those	DT
cord-023168-cd7adns8	1338	11	where	where	WRB
cord-023168-cd7adns8	1338	12	the	the	DT
cord-023168-cd7adns8	1338	13	malaria	malaria	NN
cord-023168-cd7adns8	1338	14	transmission	transmission	NN
cord-023168-cd7adns8	1338	15	rate	rate	NN
cord-023168-cd7adns8	1338	16	is	be	VBZ
cord-023168-cd7adns8	1338	17	high	high	JJ
cord-023168-cd7adns8	1338	18	,	,	,
cord-023168-cd7adns8	1338	19	most	most	JJS
cord-023168-cd7adns8	1338	20	transfusions	transfusion	NNS
cord-023168-cd7adns8	1338	21	are	be	VBP
cord-023168-cd7adns8	1338	22	given	give	VBN
cord-023168-cd7adns8	1338	23	for	for	IN
cord-023168-cd7adns8	1338	24	life	life	NN
cord-023168-cd7adns8	1338	25	-	-	HYPH
cord-023168-cd7adns8	1338	26	threatening	threaten	VBG
cord-023168-cd7adns8	1338	27	emergencies	emergency	NNS
cord-023168-cd7adns8	1338	28	.	.	.
cord-023168-cd7adns8	1339	1	In	in	IN
cord-023168-cd7adns8	1339	2	low	low	JJ
cord-023168-cd7adns8	1339	3	-	-	HYPH
cord-023168-cd7adns8	1339	4	income	income	NN
cord-023168-cd7adns8	1339	5	countries	country	NNS
cord-023168-cd7adns8	1339	6	,	,	,
cord-023168-cd7adns8	1339	7	50	50	CD
cord-023168-cd7adns8	1339	8	-	-	SYM
cord-023168-cd7adns8	1339	9	80	80	CD
cord-023168-cd7adns8	1339	10	%	%	NN
cord-023168-cd7adns8	1339	11	of	of	IN
cord-023168-cd7adns8	1339	12	transfusions	transfusion	NNS
cord-023168-cd7adns8	1339	13	are	be	VBP
cord-023168-cd7adns8	1339	14	administered	administer	VBN
cord-023168-cd7adns8	1339	15	to	to	IN
cord-023168-cd7adns8	1339	16	children	child	NNS
cord-023168-cd7adns8	1339	17	,	,	,
cord-023168-cd7adns8	1339	18	predominantly	predominantly	RB
cord-023168-cd7adns8	1339	19	for	for	IN
cord-023168-cd7adns8	1339	20	malaria	malaria	NN
cord-023168-cd7adns8	1339	21	-	-	HYPH
cord-023168-cd7adns8	1339	22	related	relate	VBN
cord-023168-cd7adns8	1339	23	anaemia	anaemia	NN
cord-023168-cd7adns8	1339	24	,	,	,
cord-023168-cd7adns8	1339	25	and	and	CC
cord-023168-cd7adns8	1339	26	pregnant	pregnant	JJ
cord-023168-cd7adns8	1339	27	women	woman	NNS
cord-023168-cd7adns8	1339	28	.	.	.
cord-023168-cd7adns8	1340	1	Transfusion	transfusion	NN
cord-023168-cd7adns8	1340	2	can	can	MD
cord-023168-cd7adns8	1340	3	significantly	significantly	RB
cord-023168-cd7adns8	1340	4	reduce	reduce	VB
cord-023168-cd7adns8	1340	5	the	the	DT
cord-023168-cd7adns8	1340	6	mortality	mortality	NN
cord-023168-cd7adns8	1340	7	of	of	IN
cord-023168-cd7adns8	1340	8	children	child	NNS
cord-023168-cd7adns8	1340	9	with	with	IN
cord-023168-cd7adns8	1340	10	severe	severe	JJ
cord-023168-cd7adns8	1340	11	anaemia	anaemia	NN
cord-023168-cd7adns8	1340	12	within	within	IN
cord-023168-cd7adns8	1340	13	the	the	DT
cord-023168-cd7adns8	1340	14	first	first	JJ
cord-023168-cd7adns8	1340	15	2	2	CD
cord-023168-cd7adns8	1340	16	days	day	NNS
cord-023168-cd7adns8	1340	17	of	of	IN
cord-023168-cd7adns8	1340	18	hospital	hospital	NN
cord-023168-cd7adns8	1340	19	admission	admission	NN
cord-023168-cd7adns8	1340	20	347	347	CD
cord-023168-cd7adns8	1340	21	and	and	CC
cord-023168-cd7adns8	1340	22	successful	successful	JJ
cord-023168-cd7adns8	1340	23	malaria	malaria	NN
cord-023168-cd7adns8	1340	24	control	control	NN
cord-023168-cd7adns8	1340	25	can	can	MD
cord-023168-cd7adns8	1340	26	reduce	reduce	VB
cord-023168-cd7adns8	1340	27	paediatric	paediatric	JJ
cord-023168-cd7adns8	1340	28	transfusion	transfusion	NN
cord-023168-cd7adns8	1340	29	requirements	requirement	NNS
cord-023168-cd7adns8	1340	30	.	.	.
cord-023168-cd7adns8	1341	1	348	348	CD
cord-023168-cd7adns8	1342	1	In	in	IN
cord-023168-cd7adns8	1342	2	sub	sub	JJ
cord-023168-cd7adns8	1342	3	-	-	JJ
cord-023168-cd7adns8	1342	4	Saharan	Saharan	NNP
cord-023168-cd7adns8	1342	5	Africa	Africa	NNP
cord-023168-cd7adns8	1342	6	,	,	,
cord-023168-cd7adns8	1342	7	26	26	CD
cord-023168-cd7adns8	1342	8	%	%	NN
cord-023168-cd7adns8	1342	9	of	of	IN
cord-023168-cd7adns8	1342	10	in	in	IN
cord-023168-cd7adns8	1342	11	-	-	HYPH
cord-023168-cd7adns8	1342	12	hospital	hospital	NN
cord-023168-cd7adns8	1342	13	maternal	maternal	JJ
cord-023168-cd7adns8	1342	14	deaths	death	NNS
cord-023168-cd7adns8	1342	15	from	from	IN
cord-023168-cd7adns8	1342	16	severe	severe	JJ
cord-023168-cd7adns8	1342	17	bleeding	bleeding	NN
cord-023168-cd7adns8	1342	18	were	be	VBD
cord-023168-cd7adns8	1342	19	due	due	JJ
cord-023168-cd7adns8	1342	20	to	to	IN
cord-023168-cd7adns8	1342	21	lack	lack	NN
cord-023168-cd7adns8	1342	22	of	of	IN
cord-023168-cd7adns8	1342	23	blood	blood	NN
cord-023168-cd7adns8	1342	24	for	for	IN
cord-023168-cd7adns8	1342	25	transfusion	transfusion	NN
cord-023168-cd7adns8	1342	26	.	.	.
cord-023168-cd7adns8	1343	1	349	349	CD
cord-023168-cd7adns8	1343	2	Other	other	JJ
cord-023168-cd7adns8	1343	3	specialities	speciality	NNS
cord-023168-cd7adns8	1343	4	which	which	WDT
cord-023168-cd7adns8	1343	5	are	be	VBP
cord-023168-cd7adns8	1343	6	significant	significant	JJ
cord-023168-cd7adns8	1343	7	users	user	NNS
cord-023168-cd7adns8	1343	8	of	of	IN
cord-023168-cd7adns8	1343	9	blood	blood	NN
cord-023168-cd7adns8	1343	10	are	be	VBP
cord-023168-cd7adns8	1343	11	surgery	surgery	NN
cord-023168-cd7adns8	1343	12	,	,	,
cord-023168-cd7adns8	1343	13	trauma	trauma	NN
cord-023168-cd7adns8	1343	14	,	,	,
cord-023168-cd7adns8	1343	15	emergency	emergency	NN
cord-023168-cd7adns8	1343	16	medicine	medicine	NN
cord-023168-cd7adns8	1343	17	and	and	CC
cord-023168-cd7adns8	1343	18	general	general	JJ
cord-023168-cd7adns8	1343	19	medicine	medicine	NN
cord-023168-cd7adns8	1343	20	.	.	.
cord-023168-cd7adns8	1344	1	In	in	IN
cord-023168-cd7adns8	1344	2	low	low	JJ
cord-023168-cd7adns8	1344	3	-	-	HYPH
cord-023168-cd7adns8	1344	4	income	income	NN
cord-023168-cd7adns8	1344	5	countries	country	NNS
cord-023168-cd7adns8	1344	6	the	the	DT
cord-023168-cd7adns8	1344	7	most	most	RBS
cord-023168-cd7adns8	1344	8	effective	effective	JJ
cord-023168-cd7adns8	1344	9	way	way	NN
cord-023168-cd7adns8	1344	10	to	to	TO
cord-023168-cd7adns8	1344	11	avoid	avoid	VB
cord-023168-cd7adns8	1344	12	transfusions	transfusion	NNS
cord-023168-cd7adns8	1344	13	is	be	VBZ
cord-023168-cd7adns8	1344	14	to	to	TO
cord-023168-cd7adns8	1344	15	reduce	reduce	VB
cord-023168-cd7adns8	1344	16	the	the	DT
cord-023168-cd7adns8	1344	17	prevalence	prevalence	NN
cord-023168-cd7adns8	1344	18	of	of	IN
cord-023168-cd7adns8	1344	19	anaemia	anaemia	NN
cord-023168-cd7adns8	1344	20	.	.	.
cord-023168-cd7adns8	1345	1	More	More	JJR
cord-023168-cd7adns8	1345	2	studies	study	NNS
cord-023168-cd7adns8	1345	3	on	on	IN
cord-023168-cd7adns8	1345	4	the	the	DT
cord-023168-cd7adns8	1345	5	efficacy	efficacy	NN
cord-023168-cd7adns8	1345	6	and	and	CC
cord-023168-cd7adns8	1345	7	cost	cost	NN
cord-023168-cd7adns8	1345	8	of	of	IN
cord-023168-cd7adns8	1345	9	combinations	combination	NNS
cord-023168-cd7adns8	1345	10	of	of	IN
cord-023168-cd7adns8	1345	11	interventions	intervention	NNS
cord-023168-cd7adns8	1345	12	including	include	VBG
cord-023168-cd7adns8	1345	13	insecticide	insecticide	NN
cord-023168-cd7adns8	1345	14	-	-	HYPH
cord-023168-cd7adns8	1345	15	treated	treat	VBN
cord-023168-cd7adns8	1345	16	bed	bed	NN
cord-023168-cd7adns8	1345	17	nets	net	NNS
cord-023168-cd7adns8	1345	18	,	,	,
cord-023168-cd7adns8	1345	19	nutritional	nutritional	JJ
cord-023168-cd7adns8	1345	20	supplements	supplement	NNS
cord-023168-cd7adns8	1345	21	and	and	CC
cord-023168-cd7adns8	1345	22	anthelmintic	anthelmintic	JJ
cord-023168-cd7adns8	1345	23	drugs	drug	NNS
cord-023168-cd7adns8	1345	24	to	to	TO
cord-023168-cd7adns8	1345	25	prevent	prevent	VB
cord-023168-cd7adns8	1345	26	anaemia	anaemia	NN
cord-023168-cd7adns8	1345	27	are	be	VBP
cord-023168-cd7adns8	1345	28	needed	need	VBN
cord-023168-cd7adns8	1345	29	.	.	.
cord-023168-cd7adns8	1346	1	When	when	WRB
cord-023168-cd7adns8	1346	2	resources	resource	NNS
cord-023168-cd7adns8	1346	3	are	be	VBP
cord-023168-cd7adns8	1346	4	very	very	RB
cord-023168-cd7adns8	1346	5	limited	limited	JJ
cord-023168-cd7adns8	1346	6	,	,	,
cord-023168-cd7adns8	1346	7	governments	government	NNS
cord-023168-cd7adns8	1346	8	may	may	MD
cord-023168-cd7adns8	1346	9	need	need	VB
cord-023168-cd7adns8	1346	10	to	to	TO
cord-023168-cd7adns8	1346	11	make	make	VB
cord-023168-cd7adns8	1346	12	some	some	DT
cord-023168-cd7adns8	1346	13	difficult	difficult	JJ
cord-023168-cd7adns8	1346	14	decisions	decision	NNS
cord-023168-cd7adns8	1346	15	in	in	IN
cord-023168-cd7adns8	1346	16	order	order	NN
cord-023168-cd7adns8	1346	17	to	to	TO
cord-023168-cd7adns8	1346	18	achieve	achieve	VB
cord-023168-cd7adns8	1346	19	an	an	DT
cord-023168-cd7adns8	1346	20	equitable	equitable	JJ
cord-023168-cd7adns8	1346	21	balance	balance	NN
cord-023168-cd7adns8	1346	22	between	between	IN
cord-023168-cd7adns8	1346	23	investing	investing	NN
cord-023168-cd7adns8	1346	24	in	in	IN
cord-023168-cd7adns8	1346	25	a	a	DT
cord-023168-cd7adns8	1346	26	transfusion	transfusion	NN
cord-023168-cd7adns8	1346	27	service	service	NN
cord-023168-cd7adns8	1346	28	and	and	CC
cord-023168-cd7adns8	1346	29	public	public	JJ
cord-023168-cd7adns8	1346	30	health	health	NN
cord-023168-cd7adns8	1346	31	measures	measure	NNS
cord-023168-cd7adns8	1346	32	to	to	TO
cord-023168-cd7adns8	1346	33	reduce	reduce	VB
cord-023168-cd7adns8	1346	34	anaemia	anaemia	NN
cord-023168-cd7adns8	1346	35	.	.	.
cord-023168-cd7adns8	1347	1	Whether	whether	IN
cord-023168-cd7adns8	1347	2	a	a	DT
cord-023168-cd7adns8	1347	3	patient	patient	NN
cord-023168-cd7adns8	1347	4	needs	need	VBZ
cord-023168-cd7adns8	1347	5	a	a	DT
cord-023168-cd7adns8	1347	6	blood	blood	NN
cord-023168-cd7adns8	1347	7	transfusion	transfusion	NN
cord-023168-cd7adns8	1347	8	or	or	CC
cord-023168-cd7adns8	1347	9	not	not	RB
cord-023168-cd7adns8	1347	10	is	be	VBZ
cord-023168-cd7adns8	1347	11	ultimately	ultimately	RB
cord-023168-cd7adns8	1347	12	a	a	DT
cord-023168-cd7adns8	1347	13	clinical	clinical	JJ
cord-023168-cd7adns8	1347	14	decision	decision	NN
cord-023168-cd7adns8	1347	15	.	.	.
cord-023168-cd7adns8	1348	1	Emergency	emergency	NN
cord-023168-cd7adns8	1348	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	1348	3	can	can	MD
cord-023168-cd7adns8	1348	4	be	be	VB
cord-023168-cd7adns8	1348	5	lifesaving	lifesaving	JJ
cord-023168-cd7adns8	1348	6	for	for	IN
cord-023168-cd7adns8	1348	7	patients	patient	NNS
cord-023168-cd7adns8	1348	8	in	in	IN
cord-023168-cd7adns8	1348	9	whom	whom	WP
cord-023168-cd7adns8	1348	10	anaemia	anaemia	NN
cord-023168-cd7adns8	1348	11	has	have	VBZ
cord-023168-cd7adns8	1348	12	developed	develop	VBN
cord-023168-cd7adns8	1348	13	too	too	RB
cord-023168-cd7adns8	1348	14	quickly	quickly	RB
cord-023168-cd7adns8	1348	15	to	to	TO
cord-023168-cd7adns8	1348	16	allow	allow	VB
cord-023168-cd7adns8	1348	17	physiological	physiological	JJ
cord-023168-cd7adns8	1348	18	compensation	compensation	NN
cord-023168-cd7adns8	1348	19	,	,	,
cord-023168-cd7adns8	1348	20	as	as	IN
cord-023168-cd7adns8	1348	21	in	in	IN
cord-023168-cd7adns8	1348	22	severe	severe	JJ
cord-023168-cd7adns8	1348	23	malariarelated	malariarelated	JJ
cord-023168-cd7adns8	1348	24	anaemia	anaemia	NN
cord-023168-cd7adns8	1348	25	in	in	IN
cord-023168-cd7adns8	1348	26	children	child	NNS
cord-023168-cd7adns8	1348	27	,	,	,
cord-023168-cd7adns8	1348	28	and	and	CC
cord-023168-cd7adns8	1348	29	sudden	sudden	JJ
cord-023168-cd7adns8	1348	30	,	,	,
cord-023168-cd7adns8	1348	31	severe	severe	JJ
cord-023168-cd7adns8	1348	32	obstetric	obstetric	JJ
cord-023168-cd7adns8	1348	33	bleeding	bleeding	NN
cord-023168-cd7adns8	1348	34	.	.	.
cord-023168-cd7adns8	1349	1	In	in	IN
cord-023168-cd7adns8	1349	2	contrast	contrast	NN
cord-023168-cd7adns8	1349	3	,	,	,
cord-023168-cd7adns8	1349	4	if	if	IN
cord-023168-cd7adns8	1349	5	the	the	DT
cord-023168-cd7adns8	1349	6	anaemia	anaemia	NN
cord-023168-cd7adns8	1349	7	has	have	VBZ
cord-023168-cd7adns8	1349	8	developed	develop	VBN
cord-023168-cd7adns8	1349	9	slowly	slowly	RB
cord-023168-cd7adns8	1349	10	,	,	,
cord-023168-cd7adns8	1349	11	for	for	IN
cord-023168-cd7adns8	1349	12	example	example	NN
cord-023168-cd7adns8	1349	13	due	due	IN
cord-023168-cd7adns8	1349	14	to	to	IN
cord-023168-cd7adns8	1349	15	hookworm	hookworm	NN
cord-023168-cd7adns8	1349	16	infestation	infestation	NN
cord-023168-cd7adns8	1349	17	or	or	CC
cord-023168-cd7adns8	1349	18	nutritional	nutritional	JJ
cord-023168-cd7adns8	1349	19	deficiency	deficiency	NN
cord-023168-cd7adns8	1349	20	,	,	,
cord-023168-cd7adns8	1349	21	patients	patient	NNS
cord-023168-cd7adns8	1349	22	can	can	MD
cord-023168-cd7adns8	1349	23	generally	generally	RB
cord-023168-cd7adns8	1349	24	be	be	VB
cord-023168-cd7adns8	1349	25	managed	manage	VBN
cord-023168-cd7adns8	1349	26	conservatively	conservatively	RB
cord-023168-cd7adns8	1349	27	by	by	IN
cord-023168-cd7adns8	1349	28	treating	treat	VBG
cord-023168-cd7adns8	1349	29	the	the	DT
cord-023168-cd7adns8	1349	30	cause	cause	NN
cord-023168-cd7adns8	1349	31	of	of	IN
cord-023168-cd7adns8	1349	32	the	the	DT
cord-023168-cd7adns8	1349	33	anaemia	anaemia	NN
cord-023168-cd7adns8	1349	34	and	and	CC
cord-023168-cd7adns8	1349	35	prescribing	prescribe	VBG
cord-023168-cd7adns8	1349	36	haematinic	haematinic	JJ
cord-023168-cd7adns8	1349	37	replacements	replacement	NNS
cord-023168-cd7adns8	1349	38	.	.	.
cord-023168-cd7adns8	1350	1	Iron	iron	NN
cord-023168-cd7adns8	1350	2	supplements	supplement	NNS
cord-023168-cd7adns8	1350	3	should	should	MD
cord-023168-cd7adns8	1350	4	be	be	VB
cord-023168-cd7adns8	1350	5	continued	continue	VBN
cord-023168-cd7adns8	1350	6	for	for	IN
cord-023168-cd7adns8	1350	7	at	at	RB
cord-023168-cd7adns8	1350	8	least	least	JJS
cord-023168-cd7adns8	1350	9	3	3	CD
cord-023168-cd7adns8	1350	10	months	month	NNS
cord-023168-cd7adns8	1350	11	after	after	IN
cord-023168-cd7adns8	1350	12	the	the	DT
cord-023168-cd7adns8	1350	13	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1350	14	has	have	VBZ
cord-023168-cd7adns8	1350	15	returned	return	VBN
cord-023168-cd7adns8	1350	16	to	to	IN
cord-023168-cd7adns8	1350	17	normal	normal	JJ
cord-023168-cd7adns8	1350	18	,	,	,
cord-023168-cd7adns8	1350	19	so	so	IN
cord-023168-cd7adns8	1350	20	that	that	IN
cord-023168-cd7adns8	1350	21	body	body	NN
cord-023168-cd7adns8	1350	22	stores	store	NNS
cord-023168-cd7adns8	1350	23	can	can	MD
cord-023168-cd7adns8	1350	24	be	be	VB
cord-023168-cd7adns8	1350	25	replenished	replenish	VBN
cord-023168-cd7adns8	1350	26	.	.	.
cord-023168-cd7adns8	1351	1	Clinical	Clinical	NNP
cord-023168-cd7adns8	1351	2	Guidelines	Guidelines	NNPS
cord-023168-cd7adns8	1351	3	.	.	.
cord-023168-cd7adns8	1352	1	It	-PRON-	PRP
cord-023168-cd7adns8	1352	2	is	be	VBZ
cord-023168-cd7adns8	1352	3	possible	possible	JJ
cord-023168-cd7adns8	1352	4	to	to	TO
cord-023168-cd7adns8	1352	5	avoid	avoid	VB
cord-023168-cd7adns8	1352	6	unnecessary	unnecessary	JJ
cord-023168-cd7adns8	1352	7	transfusions	transfusion	NNS
cord-023168-cd7adns8	1352	8	by	by	IN
cord-023168-cd7adns8	1352	9	adhering	adhere	VBG
cord-023168-cd7adns8	1352	10	to	to	IN
cord-023168-cd7adns8	1352	11	clinical	clinical	JJ
cord-023168-cd7adns8	1352	12	transfusion	transfusion	NN
cord-023168-cd7adns8	1352	13	guidelines	guideline	NNS
cord-023168-cd7adns8	1352	14	.	.	.
cord-023168-cd7adns8	1353	1	Most	Most	JJS
cord-023168-cd7adns8	1353	2	institutions	institution	NNS
cord-023168-cd7adns8	1353	3	have	have	VBP
cord-023168-cd7adns8	1353	4	developed	develop	VBN
cord-023168-cd7adns8	1353	5	guidelines	guideline	NNS
cord-023168-cd7adns8	1353	6	to	to	TO
cord-023168-cd7adns8	1353	7	help	help	VB
cord-023168-cd7adns8	1353	8	clinicians	clinician	NNS
cord-023168-cd7adns8	1353	9	make	make	VB
cord-023168-cd7adns8	1353	10	rational	rational	JJ
cord-023168-cd7adns8	1353	11	decisions	decision	NNS
cord-023168-cd7adns8	1353	12	about	about	IN
cord-023168-cd7adns8	1353	13	the	the	DT
cord-023168-cd7adns8	1353	14	use	use	NN
cord-023168-cd7adns8	1353	15	of	of	IN
cord-023168-cd7adns8	1353	16	blood	blood	NN
cord-023168-cd7adns8	1353	17	transfusions	transfusion	NNS
cord-023168-cd7adns8	1353	18	(	(	-LRB-
cord-023168-cd7adns8	1353	19	Box	Box	NNP
cord-023168-cd7adns8	1353	20	65.23	65.23	CD
cord-023168-cd7adns8	1353	21	)	)	-RRB-
cord-023168-cd7adns8	1353	22	344	344	CD
cord-023168-cd7adns8	1353	23	,	,	,
cord-023168-cd7adns8	1353	24	350	350	CD
cord-023168-cd7adns8	1353	25	and	and	CC
cord-023168-cd7adns8	1353	26	strict	strict	JJ
cord-023168-cd7adns8	1353	27	enforcement	enforcement	NN
cord-023168-cd7adns8	1353	28	of	of	IN
cord-023168-cd7adns8	1353	29	transfusion	transfusion	NN
cord-023168-cd7adns8	1353	30	protocols	protocol	NNS
cord-023168-cd7adns8	1353	31	can	can	MD
cord-023168-cd7adns8	1353	32	significantly	significantly	RB
cord-023168-cd7adns8	1353	33	reduce	reduce	VB
cord-023168-cd7adns8	1353	34	avoidable	avoidable	JJ
cord-023168-cd7adns8	1353	35	transfusions	transfusion	NNS
cord-023168-cd7adns8	1353	36	.	.	.
cord-023168-cd7adns8	1354	1	351	351	CD
cord-023168-cd7adns8	1355	1	The	the	DT
cord-023168-cd7adns8	1355	2	principles	principle	NNS
cord-023168-cd7adns8	1355	3	underlying	underlie	VBG
cord-023168-cd7adns8	1355	4	most	most	JJS
cord-023168-cd7adns8	1355	5	transfusion	transfusion	NN
cord-023168-cd7adns8	1355	6	guidelines	guideline	NNS
cord-023168-cd7adns8	1355	7	are	be	VBP
cord-023168-cd7adns8	1355	8	similar	similar	JJ
cord-023168-cd7adns8	1355	9	and	and	CC
cord-023168-cd7adns8	1355	10	combine	combine	VB
cord-023168-cd7adns8	1355	11	a	a	DT
cord-023168-cd7adns8	1355	12	clinical	clinical	JJ
cord-023168-cd7adns8	1355	13	assessment	assessment	NN
cord-023168-cd7adns8	1355	14	of	of	IN
cord-023168-cd7adns8	1355	15	oxygenation	oxygenation	NN
cord-023168-cd7adns8	1355	16	,	,	,
cord-023168-cd7adns8	1355	17	with	with	IN
cord-023168-cd7adns8	1355	18	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1355	19	measurement	measurement	NN
cord-023168-cd7adns8	1355	20	being	be	VBG
cord-023168-cd7adns8	1355	21	used	use	VBN
cord-023168-cd7adns8	1355	22	as	as	IN
cord-023168-cd7adns8	1355	23	a	a	DT
cord-023168-cd7adns8	1355	24	surrogate	surrogate	JJ
cord-023168-cd7adns8	1355	25	measure	measure	NN
cord-023168-cd7adns8	1355	26	for	for	IN
cord-023168-cd7adns8	1355	27	intracellular	intracellular	JJ
cord-023168-cd7adns8	1355	28	oxygen	oxygen	NN
cord-023168-cd7adns8	1355	29	concentration	concentration	NN
cord-023168-cd7adns8	1355	30	.	.	.
cord-023168-cd7adns8	1356	1	Increasingly	increasingly	RB
cord-023168-cd7adns8	1356	2	,	,	,
cord-023168-cd7adns8	1356	3	transfusion	transfusion	NN
cord-023168-cd7adns8	1356	4	guidelines	guideline	NNS
cord-023168-cd7adns8	1356	5	are	be	VBP
cord-023168-cd7adns8	1356	6	making	make	VBG
cord-023168-cd7adns8	1356	7	use	use	NN
cord-023168-cd7adns8	1356	8	of	of	IN
cord-023168-cd7adns8	1356	9	evidence	evidence	NN
cord-023168-cd7adns8	1356	10	which	which	WDT
cord-023168-cd7adns8	1356	11	shows	show	VBZ
cord-023168-cd7adns8	1356	12	that	that	IN
cord-023168-cd7adns8	1356	13	adequate	adequate	JJ
cord-023168-cd7adns8	1356	14	oxygen	oxygen	NN
cord-023168-cd7adns8	1356	15	delivery	delivery	NN
cord-023168-cd7adns8	1356	16	to	to	IN
cord-023168-cd7adns8	1356	17	the	the	DT
cord-023168-cd7adns8	1356	18	tissues	tissue	NNS
cord-023168-cd7adns8	1356	19	can	can	MD
cord-023168-cd7adns8	1356	20	be	be	VB
cord-023168-cd7adns8	1356	21	achieved	achieve	VBN
cord-023168-cd7adns8	1356	22	at	at	IN
cord-023168-cd7adns8	1356	23	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1356	24	levels	level	NNS
cord-023168-cd7adns8	1356	25	that	that	WDT
cord-023168-cd7adns8	1356	26	are	be	VBP
cord-023168-cd7adns8	1356	27	significantly	significantly	RB
cord-023168-cd7adns8	1356	28	lower	low	JJR
cord-023168-cd7adns8	1356	29	than	than	IN
cord-023168-cd7adns8	1356	30	the	the	DT
cord-023168-cd7adns8	1356	31	normal	normal	JJ
cord-023168-cd7adns8	1356	32	range	range	NN
cord-023168-cd7adns8	1356	33	.	.	.
cord-023168-cd7adns8	1357	1	352	352	CD
cord-023168-cd7adns8	1357	2	Implementation	implementation	NN
cord-023168-cd7adns8	1357	3	of	of	IN
cord-023168-cd7adns8	1357	4	transfusion	transfusion	NN
cord-023168-cd7adns8	1357	5	guidelines	guideline	NNS
cord-023168-cd7adns8	1357	6	is	be	VBZ
cord-023168-cd7adns8	1357	7	particularly	particularly	RB
cord-023168-cd7adns8	1357	8	difficult	difficult	JJ
cord-023168-cd7adns8	1357	9	if	if	IN
cord-023168-cd7adns8	1357	10	clinicians	clinician	NNS
cord-023168-cd7adns8	1357	11	do	do	VBP
cord-023168-cd7adns8	1357	12	not	not	RB
cord-023168-cd7adns8	1357	13	have	have	VB
cord-023168-cd7adns8	1357	14	access	access	NN
cord-023168-cd7adns8	1357	15	to	to	IN
cord-023168-cd7adns8	1357	16	reliable	reliable	JJ
cord-023168-cd7adns8	1357	17	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1357	18	High	high	JJ
cord-023168-cd7adns8	1357	19	-	-	HYPH
cord-023168-cd7adns8	1357	20	risk	risk	NN
cord-023168-cd7adns8	1357	21	donors	donor	NNS
cord-023168-cd7adns8	1357	22	,	,	,
cord-023168-cd7adns8	1357	23	such	such	JJ
cord-023168-cd7adns8	1357	24	as	as	IN
cord-023168-cd7adns8	1357	25	commercial	commercial	JJ
cord-023168-cd7adns8	1357	26	sex	sex	NN
cord-023168-cd7adns8	1357	27	workers	worker	NNS
cord-023168-cd7adns8	1357	28	and	and	CC
cord-023168-cd7adns8	1357	29	their	-PRON-	PRP$
cord-023168-cd7adns8	1357	30	contacts	contact	NNS
cord-023168-cd7adns8	1357	31	,	,	,
cord-023168-cd7adns8	1357	32	intravenous	intravenous	JJ
cord-023168-cd7adns8	1357	33	drug	drug	NN
cord-023168-cd7adns8	1357	34	abusers	abuser	NNS
cord-023168-cd7adns8	1357	35	,	,	,
cord-023168-cd7adns8	1357	36	or	or	CC
cord-023168-cd7adns8	1357	37	those	those	DT
cord-023168-cd7adns8	1357	38	with	with	IN
cord-023168-cd7adns8	1357	39	an	an	DT
cord-023168-cd7adns8	1357	40	itinerant	itinerant	JJ
cord-023168-cd7adns8	1357	41	lifestyle	lifestyle	NN
cord-023168-cd7adns8	1357	42	such	such	JJ
cord-023168-cd7adns8	1357	43	as	as	IN
cord-023168-cd7adns8	1357	44	traders	trader	NNS
cord-023168-cd7adns8	1357	45	,	,	,
cord-023168-cd7adns8	1357	46	drivers	driver	NNS
cord-023168-cd7adns8	1357	47	and	and	CC
cord-023168-cd7adns8	1357	48	military	military	JJ
cord-023168-cd7adns8	1357	49	personnel	personnel	NNS
cord-023168-cd7adns8	1357	50	,	,	,
cord-023168-cd7adns8	1357	51	should	should	MD
cord-023168-cd7adns8	1357	52	be	be	VB
cord-023168-cd7adns8	1357	53	deterred	deter	VBN
cord-023168-cd7adns8	1357	54	from	from	IN
cord-023168-cd7adns8	1357	55	donating	donate	VBG
cord-023168-cd7adns8	1357	56	.	.	.
cord-023168-cd7adns8	1358	1	338	338	CD
cord-023168-cd7adns8	1359	1	Even	even	RB
cord-023168-cd7adns8	1359	2	in	in	IN
cord-023168-cd7adns8	1359	3	areas	area	NNS
cord-023168-cd7adns8	1359	4	where	where	WRB
cord-023168-cd7adns8	1359	5	HIV	HIV	NNP
cord-023168-cd7adns8	1359	6	infection	infection	NN
cord-023168-cd7adns8	1359	7	rates	rate	NNS
cord-023168-cd7adns8	1359	8	in	in	IN
cord-023168-cd7adns8	1359	9	the	the	DT
cord-023168-cd7adns8	1359	10	general	general	JJ
cord-023168-cd7adns8	1359	11	population	population	NN
cord-023168-cd7adns8	1359	12	are	be	VBP
cord-023168-cd7adns8	1359	13	high	high	JJ
cord-023168-cd7adns8	1359	14	,	,	,
cord-023168-cd7adns8	1359	15	donor	donor	NN
cord-023168-cd7adns8	1359	16	deferral	deferral	NN
cord-023168-cd7adns8	1359	17	can	can	MD
cord-023168-cd7adns8	1359	18	be	be	VB
cord-023168-cd7adns8	1359	19	effective	effective	JJ
cord-023168-cd7adns8	1359	20	in	in	IN
cord-023168-cd7adns8	1359	21	excluding	exclude	VBG
cord-023168-cd7adns8	1359	22	HIV	HIV	NNP
cord-023168-cd7adns8	1359	23	-	-	HYPH
cord-023168-cd7adns8	1359	24	infected	infect	VBN
cord-023168-cd7adns8	1359	25	donors	donor	NNS
cord-023168-cd7adns8	1359	26	.	.	.
cord-023168-cd7adns8	1360	1	339	339	CD
cord-023168-cd7adns8	1361	1	The	the	DT
cord-023168-cd7adns8	1361	2	whole	whole	JJ
cord-023168-cd7adns8	1361	3	donation	donation	NN
cord-023168-cd7adns8	1361	4	process	process	NN
cord-023168-cd7adns8	1361	5	,	,	,
cord-023168-cd7adns8	1361	6	including	include	VBG
cord-023168-cd7adns8	1361	7	tests	test	NNS
cord-023168-cd7adns8	1361	8	for	for	IN
cord-023168-cd7adns8	1361	9	HIV	HIV	NNP
cord-023168-cd7adns8	1361	10	and	and	CC
cord-023168-cd7adns8	1361	11	other	other	JJ
cord-023168-cd7adns8	1361	12	infections	infection	NNS
cord-023168-cd7adns8	1361	13	,	,	,
cord-023168-cd7adns8	1361	14	should	should	MD
cord-023168-cd7adns8	1361	15	be	be	VB
cord-023168-cd7adns8	1361	16	explained	explain	VBN
cord-023168-cd7adns8	1361	17	to	to	IN
cord-023168-cd7adns8	1361	18	the	the	DT
cord-023168-cd7adns8	1361	19	donor	donor	NN
cord-023168-cd7adns8	1361	20	before	before	IN
cord-023168-cd7adns8	1361	21	blood	blood	NN
cord-023168-cd7adns8	1361	22	is	be	VBZ
cord-023168-cd7adns8	1361	23	collected	collect	VBN
cord-023168-cd7adns8	1361	24	and	and	CC
cord-023168-cd7adns8	1361	25	donors	donor	NNS
cord-023168-cd7adns8	1361	26	should	should	MD
cord-023168-cd7adns8	1361	27	have	have	VB
cord-023168-cd7adns8	1361	28	the	the	DT
cord-023168-cd7adns8	1361	29	option	option	NN
cord-023168-cd7adns8	1361	30	of	of	IN
cord-023168-cd7adns8	1361	31	knowing	know	VBG
cord-023168-cd7adns8	1361	32	the	the	DT
cord-023168-cd7adns8	1361	33	results	result	NNS
cord-023168-cd7adns8	1361	34	and	and	CC
cord-023168-cd7adns8	1361	35	receiving	receive	VBG
cord-023168-cd7adns8	1361	36	counselling	counselling	NN
cord-023168-cd7adns8	1361	37	.	.	.
cord-023168-cd7adns8	1362	1	It	-PRON-	PRP
cord-023168-cd7adns8	1362	2	is	be	VBZ
cord-023168-cd7adns8	1362	3	imperative	imperative	JJ
cord-023168-cd7adns8	1362	4	that	that	IN
cord-023168-cd7adns8	1362	5	complete	complete	JJ
cord-023168-cd7adns8	1362	6	confidentiality	confidentiality	NN
cord-023168-cd7adns8	1362	7	is	be	VBZ
cord-023168-cd7adns8	1362	8	maintained	maintain	VBN
cord-023168-cd7adns8	1362	9	throughout	throughout	IN
cord-023168-cd7adns8	1362	10	all	all	DT
cord-023168-cd7adns8	1362	11	procedures	procedure	NNS
cord-023168-cd7adns8	1362	12	.	.	.
cord-023168-cd7adns8	1363	1	Infections	infection	NNS
cord-023168-cd7adns8	1363	2	with	with	IN
cord-023168-cd7adns8	1363	3	organisms	organism	NNS
cord-023168-cd7adns8	1363	4	such	such	JJ
cord-023168-cd7adns8	1363	5	as	as	IN
cord-023168-cd7adns8	1363	6	HIV	HIV	NNP
cord-023168-cd7adns8	1363	7	,	,	,
cord-023168-cd7adns8	1363	8	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1363	9	viruses	virus	NNS
cord-023168-cd7adns8	1363	10	,	,	,
cord-023168-cd7adns8	1363	11	cytomegalovirus	cytomegalovirus	NNP
cord-023168-cd7adns8	1363	12	,	,	,
cord-023168-cd7adns8	1363	13	syphilis	syphili	NNS
cord-023168-cd7adns8	1363	14	,	,	,
cord-023168-cd7adns8	1363	15	lyme	lyme	NNP
cord-023168-cd7adns8	1363	16	borreliosis	borreliosis	NNP
cord-023168-cd7adns8	1363	17	,	,	,
cord-023168-cd7adns8	1363	18	malaria	malaria	NN
cord-023168-cd7adns8	1363	19	,	,	,
cord-023168-cd7adns8	1363	20	babesiosis	babesiosis	NN
cord-023168-cd7adns8	1363	21	,	,	,
cord-023168-cd7adns8	1363	22	American	american	JJ
cord-023168-cd7adns8	1363	23	trypanosomiasis	trypanosomiasis	NN
cord-023168-cd7adns8	1363	24	(	(	-LRB-
cord-023168-cd7adns8	1363	25	Chagas	Chagas	NNP
cord-023168-cd7adns8	1363	26	disease	disease	NN
cord-023168-cd7adns8	1363	27	)	)	-RRB-
cord-023168-cd7adns8	1363	28	and	and	CC
cord-023168-cd7adns8	1363	29	toxoplasmosis	toxoplasmosis	NN
cord-023168-cd7adns8	1363	30	can	can	MD
cord-023168-cd7adns8	1363	31	all	all	RB
cord-023168-cd7adns8	1363	32	be	be	VB
cord-023168-cd7adns8	1363	33	acquired	acquire	VBN
cord-023168-cd7adns8	1363	34	through	through	IN
cord-023168-cd7adns8	1363	35	blood	blood	NN
cord-023168-cd7adns8	1363	36	transfusions	transfusion	NNS
cord-023168-cd7adns8	1363	37	.	.	.
cord-023168-cd7adns8	1364	1	Some	some	DT
cord-023168-cd7adns8	1364	2	5	5	CD
cord-023168-cd7adns8	1364	3	-	-	SYM
cord-023168-cd7adns8	1364	4	10	10	CD
cord-023168-cd7adns8	1364	5	%	%	NN
cord-023168-cd7adns8	1364	6	of	of	IN
cord-023168-cd7adns8	1364	7	HIV	HIV	NNP
cord-023168-cd7adns8	1364	8	infections	infection	NNS
cord-023168-cd7adns8	1364	9	worldwide	worldwide	RB
cord-023168-cd7adns8	1364	10	are	be	VBP
cord-023168-cd7adns8	1364	11	thought	think	VBN
cord-023168-cd7adns8	1364	12	to	to	TO
cord-023168-cd7adns8	1364	13	have	have	VB
cord-023168-cd7adns8	1364	14	been	be	VBN
cord-023168-cd7adns8	1364	15	transmitted	transmit	VBN
cord-023168-cd7adns8	1364	16	through	through	IN
cord-023168-cd7adns8	1364	17	the	the	DT
cord-023168-cd7adns8	1364	18	transfusion	transfusion	NN
cord-023168-cd7adns8	1364	19	of	of	IN
cord-023168-cd7adns8	1364	20	infected	infected	JJ
cord-023168-cd7adns8	1364	21	blood	blood	NN
cord-023168-cd7adns8	1364	22	and	and	CC
cord-023168-cd7adns8	1364	23	blood	blood	NN
cord-023168-cd7adns8	1364	24	products	product	NNS
cord-023168-cd7adns8	1364	25	.	.	.
cord-023168-cd7adns8	1365	1	There	there	EX
cord-023168-cd7adns8	1365	2	have	have	VBP
cord-023168-cd7adns8	1365	3	also	also	RB
cord-023168-cd7adns8	1365	4	been	be	VBN
cord-023168-cd7adns8	1365	5	reports	report	NNS
cord-023168-cd7adns8	1365	6	of	of	IN
cord-023168-cd7adns8	1365	7	transmission	transmission	NN
cord-023168-cd7adns8	1365	8	of	of	IN
cord-023168-cd7adns8	1365	9	variant	variant	JJ
cord-023168-cd7adns8	1365	10	Creutzfeldt	Creutzfeldt	NNP
cord-023168-cd7adns8	1365	11	-	-	HYPH
cord-023168-cd7adns8	1365	12	Jakob	Jakob	NNP
cord-023168-cd7adns8	1365	13	disease	disease	NN
cord-023168-cd7adns8	1365	14	through	through	IN
cord-023168-cd7adns8	1365	15	blood	blood	NN
cord-023168-cd7adns8	1365	16	transfusion	transfusion	NN
cord-023168-cd7adns8	1365	17	and	and	CC
cord-023168-cd7adns8	1365	18	there	there	EX
cord-023168-cd7adns8	1365	19	is	be	VBZ
cord-023168-cd7adns8	1365	20	a	a	DT
cord-023168-cd7adns8	1365	21	theoretical	theoretical	JJ
cord-023168-cd7adns8	1365	22	risk	risk	NN
cord-023168-cd7adns8	1365	23	of	of	IN
cord-023168-cd7adns8	1365	24	transmission	transmission	NN
cord-023168-cd7adns8	1365	25	of	of	IN
cord-023168-cd7adns8	1365	26	severe	severe	JJ
cord-023168-cd7adns8	1365	27	acute	acute	JJ
cord-023168-cd7adns8	1365	28	respiratory	respiratory	JJ
cord-023168-cd7adns8	1365	29	syndrome	syndrome	NN
cord-023168-cd7adns8	1365	30	(	(	-LRB-
cord-023168-cd7adns8	1365	31	SARS	SARS	NNP
cord-023168-cd7adns8	1365	32	)	)	-RRB-
cord-023168-cd7adns8	1365	33	.	.	.
cord-023168-cd7adns8	1366	1	340	340	CD
cord-023168-cd7adns8	1366	2	,	,	,
cord-023168-cd7adns8	1366	3	341	341	CD
cord-023168-cd7adns8	1366	4	WHO	who	WP
cord-023168-cd7adns8	1366	5	recommends	recommend	VBZ
cord-023168-cd7adns8	1366	6	that	that	IN
cord-023168-cd7adns8	1366	7	all	all	DT
cord-023168-cd7adns8	1366	8	donated	donate	VBN
cord-023168-cd7adns8	1366	9	blood	blood	NN
cord-023168-cd7adns8	1366	10	should	should	MD
cord-023168-cd7adns8	1366	11	be	be	VB
cord-023168-cd7adns8	1366	12	screened	screen	VBN
cord-023168-cd7adns8	1366	13	for	for	IN
cord-023168-cd7adns8	1366	14	HIV	HIV	NNP
cord-023168-cd7adns8	1366	15	,	,	,
cord-023168-cd7adns8	1366	16	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1366	17	B	b	NN
cord-023168-cd7adns8	1366	18	and	and	CC
cord-023168-cd7adns8	1366	19	syphilis	syphili	NNS
cord-023168-cd7adns8	1367	1	and	and	CC
cord-023168-cd7adns8	1367	2	,	,	,
cord-023168-cd7adns8	1367	3	where	where	WRB
cord-023168-cd7adns8	1367	4	feasible	feasible	JJ
cord-023168-cd7adns8	1367	5	and	and	CC
cord-023168-cd7adns8	1367	6	appropriate	appropriate	JJ
cord-023168-cd7adns8	1367	7	,	,	,
cord-023168-cd7adns8	1367	8	for	for	IN
cord-023168-cd7adns8	1367	9	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1367	10	C	C	NNP
cord-023168-cd7adns8	1367	11	,	,	,
cord-023168-cd7adns8	1367	12	malaria	malaria	NN
cord-023168-cd7adns8	1367	13	and	and	CC
cord-023168-cd7adns8	1367	14	Chagas	Chagas	NNP
cord-023168-cd7adns8	1367	15	disease	disease	NN
cord-023168-cd7adns8	1367	16	.	.	.
cord-023168-cd7adns8	1368	1	Malaria	Malaria	NNP
cord-023168-cd7adns8	1368	2	can	can	MD
cord-023168-cd7adns8	1368	3	be	be	VB
cord-023168-cd7adns8	1368	4	transmitted	transmit	VBN
cord-023168-cd7adns8	1368	5	by	by	IN
cord-023168-cd7adns8	1368	6	blood	blood	NN
cord-023168-cd7adns8	1368	7	transfusion	transfusion	NN
cord-023168-cd7adns8	1368	8	and	and	CC
cord-023168-cd7adns8	1368	9	,	,	,
cord-023168-cd7adns8	1368	10	depending	depend	VBG
cord-023168-cd7adns8	1368	11	on	on	IN
cord-023168-cd7adns8	1368	12	the	the	DT
cord-023168-cd7adns8	1368	13	local	local	JJ
cord-023168-cd7adns8	1368	14	infection	infection	NN
cord-023168-cd7adns8	1368	15	prevalence	prevalence	NN
cord-023168-cd7adns8	1368	16	,	,	,
cord-023168-cd7adns8	1368	17	2	2	CD
cord-023168-cd7adns8	1368	18	-	-	SYM
cord-023168-cd7adns8	1368	19	55	55	CD
cord-023168-cd7adns8	1368	20	%	%	NN
cord-023168-cd7adns8	1368	21	of	of	IN
cord-023168-cd7adns8	1368	22	blood	blood	NN
cord-023168-cd7adns8	1368	23	donors	donor	NNS
cord-023168-cd7adns8	1368	24	in	in	IN
cord-023168-cd7adns8	1368	25	Africa	Africa	NNP
cord-023168-cd7adns8	1368	26	screen	screen	NN
cord-023168-cd7adns8	1368	27	positive	positive	JJ
cord-023168-cd7adns8	1368	28	for	for	IN
cord-023168-cd7adns8	1368	29	malaria	malaria	NN
cord-023168-cd7adns8	1368	30	.	.	.
cord-023168-cd7adns8	1369	1	342	342	CD
cord-023168-cd7adns8	1370	1	However	however	RB
cord-023168-cd7adns8	1370	2	,	,	,
cord-023168-cd7adns8	1370	3	there	there	EX
cord-023168-cd7adns8	1370	4	is	be	VBZ
cord-023168-cd7adns8	1370	5	very	very	RB
cord-023168-cd7adns8	1370	6	little	little	JJ
cord-023168-cd7adns8	1370	7	evidence	evidence	NN
cord-023168-cd7adns8	1370	8	to	to	TO
cord-023168-cd7adns8	1370	9	suggest	suggest	VB
cord-023168-cd7adns8	1370	10	that	that	IN
cord-023168-cd7adns8	1370	11	these	these	DT
cord-023168-cd7adns8	1370	12	donors	donor	NNS
cord-023168-cd7adns8	1370	13	transmit	transmit	VBP
cord-023168-cd7adns8	1370	14	malaria	malaria	NN
cord-023168-cd7adns8	1370	15	to	to	IN
cord-023168-cd7adns8	1370	16	transfusion	transfusion	NN
cord-023168-cd7adns8	1370	17	recipients	recipient	NNS
cord-023168-cd7adns8	1370	18	.	.	.
cord-023168-cd7adns8	1371	1	Although	although	IN
cord-023168-cd7adns8	1371	2	WHO	WHO	NNP
cord-023168-cd7adns8	1371	3	recommends	recommend	VBZ
cord-023168-cd7adns8	1371	4	screening	screen	VBG
cord-023168-cd7adns8	1371	5	donors	donor	NNS
cord-023168-cd7adns8	1371	6	in	in	IN
cord-023168-cd7adns8	1371	7	endemic	endemic	JJ
cord-023168-cd7adns8	1371	8	areas	area	NNS
cord-023168-cd7adns8	1371	9	for	for	IN
cord-023168-cd7adns8	1371	10	malaria	malaria	NN
cord-023168-cd7adns8	1371	11	,	,	,
cord-023168-cd7adns8	1371	12	none	none	NN
cord-023168-cd7adns8	1371	13	of	of	IN
cord-023168-cd7adns8	1371	14	the	the	DT
cord-023168-cd7adns8	1371	15	screening	screening	NN
cord-023168-cd7adns8	1371	16	methods	method	NNS
cord-023168-cd7adns8	1371	17	that	that	WDT
cord-023168-cd7adns8	1371	18	would	would	MD
cord-023168-cd7adns8	1371	19	be	be	VB
cord-023168-cd7adns8	1371	20	practical	practical	JJ
cord-023168-cd7adns8	1371	21	for	for	IN
cord-023168-cd7adns8	1371	22	transfusion	transfusion	NN
cord-023168-cd7adns8	1371	23	services	service	NNS
cord-023168-cd7adns8	1371	24	are	be	VBP
cord-023168-cd7adns8	1371	25	sufficiently	sufficiently	RB
cord-023168-cd7adns8	1371	26	sensitive	sensitive	JJ
cord-023168-cd7adns8	1371	27	.	.	.
cord-023168-cd7adns8	1372	1	Furthermore	furthermore	RB
cord-023168-cd7adns8	1372	2	,	,	,
cord-023168-cd7adns8	1372	3	in	in	IN
cord-023168-cd7adns8	1372	4	some	some	DT
cord-023168-cd7adns8	1372	5	countries	country	NNS
cord-023168-cd7adns8	1372	6	with	with	IN
cord-023168-cd7adns8	1372	7	high	high	JJ
cord-023168-cd7adns8	1372	8	malaria	malaria	NN
cord-023168-cd7adns8	1372	9	transmission	transmission	NN
cord-023168-cd7adns8	1372	10	,	,	,
cord-023168-cd7adns8	1372	11	exclusion	exclusion	NN
cord-023168-cd7adns8	1372	12	of	of	IN
cord-023168-cd7adns8	1372	13	parasitaemic	parasitaemic	JJ
cord-023168-cd7adns8	1372	14	donors	donor	NNS
cord-023168-cd7adns8	1372	15	could	could	MD
cord-023168-cd7adns8	1372	16	result	result	VB
cord-023168-cd7adns8	1372	17	in	in	IN
cord-023168-cd7adns8	1372	18	deferral	deferral	NN
cord-023168-cd7adns8	1372	19	rates	rate	NNS
cord-023168-cd7adns8	1372	20	exceeding	exceed	VBG
cord-023168-cd7adns8	1372	21	50	50	CD
cord-023168-cd7adns8	1372	22	%	%	NN
cord-023168-cd7adns8	1372	23	which	which	WDT
cord-023168-cd7adns8	1372	24	would	would	MD
cord-023168-cd7adns8	1372	25	have	have	VB
cord-023168-cd7adns8	1372	26	a	a	DT
cord-023168-cd7adns8	1372	27	major	major	JJ
cord-023168-cd7adns8	1372	28	impact	impact	NN
cord-023168-cd7adns8	1372	29	on	on	IN
cord-023168-cd7adns8	1372	30	blood	blood	NN
cord-023168-cd7adns8	1372	31	supply	supply	NN
cord-023168-cd7adns8	1372	32	.	.	.
cord-023168-cd7adns8	1373	1	343	343	CD
cord-023168-cd7adns8	1374	1	There	there	EX
cord-023168-cd7adns8	1374	2	is	be	VBZ
cord-023168-cd7adns8	1374	3	no	no	DT
cord-023168-cd7adns8	1374	4	evidence	evidence	NN
cord-023168-cd7adns8	1374	5	to	to	TO
cord-023168-cd7adns8	1374	6	support	support	VB
cord-023168-cd7adns8	1374	7	the	the	DT
cord-023168-cd7adns8	1374	8	widespread	widespread	JJ
cord-023168-cd7adns8	1374	9	practice	practice	NN
cord-023168-cd7adns8	1374	10	of	of	IN
cord-023168-cd7adns8	1374	11	routine	routine	JJ
cord-023168-cd7adns8	1374	12	treatment	treatment	NN
cord-023168-cd7adns8	1374	13	of	of	IN
cord-023168-cd7adns8	1374	14	transfusion	transfusion	NN
cord-023168-cd7adns8	1374	15	recipients	recipient	NNS
cord-023168-cd7adns8	1374	16	for	for	IN
cord-023168-cd7adns8	1374	17	malaria	malaria	NN
cord-023168-cd7adns8	1374	18	.	.	.
cord-023168-cd7adns8	1375	1	Fresh	fresh	JJ
cord-023168-cd7adns8	1375	2	blood	blood	NN
cord-023168-cd7adns8	1375	3	is	be	VBZ
cord-023168-cd7adns8	1375	4	potentially	potentially	RB
cord-023168-cd7adns8	1375	5	infectious	infectious	JJ
cord-023168-cd7adns8	1375	6	for	for	IN
cord-023168-cd7adns8	1375	7	syphilis	syphili	NNS
cord-023168-cd7adns8	1375	8	,	,	,
cord-023168-cd7adns8	1375	9	but	but	CC
cord-023168-cd7adns8	1375	10	storage	storage	NN
cord-023168-cd7adns8	1375	11	at	at	IN
cord-023168-cd7adns8	1375	12	4	4	CD
cord-023168-cd7adns8	1375	13	°	°	NN
cord-023168-cd7adns8	1375	14	C	c	NN
cord-023168-cd7adns8	1375	15	for	for	IN
cord-023168-cd7adns8	1375	16	more	more	JJR
cord-023168-cd7adns8	1375	17	than	than	IN
cord-023168-cd7adns8	1375	18	5	5	CD
cord-023168-cd7adns8	1375	19	days	day	NNS
cord-023168-cd7adns8	1375	20	can	can	MD
cord-023168-cd7adns8	1375	21	inactivate	inactivate	VB
cord-023168-cd7adns8	1375	22	Treponema	Treponema	NNP
cord-023168-cd7adns8	1375	23	pallidum	pallidum	NN
cord-023168-cd7adns8	1375	24	.	.	.
cord-023168-cd7adns8	1376	1	The	the	DT
cord-023168-cd7adns8	1376	2	high	high	JJ
cord-023168-cd7adns8	1376	3	demand	demand	NN
cord-023168-cd7adns8	1376	4	for	for	IN
cord-023168-cd7adns8	1376	5	blood	blood	NN
cord-023168-cd7adns8	1376	6	in	in	IN
cord-023168-cd7adns8	1376	7	low	low	JJ
cord-023168-cd7adns8	1376	8	-	-	HYPH
cord-023168-cd7adns8	1376	9	income	income	NN
cord-023168-cd7adns8	1376	10	countries	country	NNS
cord-023168-cd7adns8	1376	11	means	mean	VBZ
cord-023168-cd7adns8	1376	12	that	that	IN
cord-023168-cd7adns8	1376	13	blood	blood	NN
cord-023168-cd7adns8	1376	14	is	be	VBZ
cord-023168-cd7adns8	1376	15	generally	generally	RB
cord-023168-cd7adns8	1376	16	not	not	RB
cord-023168-cd7adns8	1376	17	stored	store	VBN
cord-023168-cd7adns8	1376	18	for	for	IN
cord-023168-cd7adns8	1376	19	long	long	JJ
cord-023168-cd7adns8	1376	20	enough	enough	RB
cord-023168-cd7adns8	1376	21	to	to	TO
cord-023168-cd7adns8	1376	22	inactivate	inactivate	VB
cord-023168-cd7adns8	1376	23	T.	T.	NNP
cord-023168-cd7adns8	1376	24	pallidum	pallidum	NN
cord-023168-cd7adns8	1376	25	and	and	CC
cord-023168-cd7adns8	1376	26	syphilis	syphili	NNS
cord-023168-cd7adns8	1376	27	seroconversion	seroconversion	NN
cord-023168-cd7adns8	1376	28	associated	associate	VBN
cord-023168-cd7adns8	1376	29	with	with	IN
cord-023168-cd7adns8	1376	30	transfusion	transfusion	NN
cord-023168-cd7adns8	1376	31	has	have	VBZ
cord-023168-cd7adns8	1376	32	been	be	VBN
cord-023168-cd7adns8	1376	33	reported	report	VBN
cord-023168-cd7adns8	1376	34	from	from	IN
cord-023168-cd7adns8	1376	35	Africa	Africa	NNP
cord-023168-cd7adns8	1376	36	.	.	.
cord-023168-cd7adns8	1377	1	344	344	CD
cord-023168-cd7adns8	1378	1	Globally	globally	RB
cord-023168-cd7adns8	1378	2	,	,	,
cord-023168-cd7adns8	1378	3	the	the	DT
cord-023168-cd7adns8	1378	4	prevalence	prevalence	NN
cord-023168-cd7adns8	1378	5	of	of	IN
cord-023168-cd7adns8	1378	6	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1378	7	C	C	NNP
cord-023168-cd7adns8	1378	8	,	,	,
cord-023168-cd7adns8	1378	9	HTLV-1	HTLV-1	NNP
cord-023168-cd7adns8	1378	10	and	and	CC
cord-023168-cd7adns8	1378	11	-2	-2	NNP
cord-023168-cd7adns8	1378	12	and	and	CC
cord-023168-cd7adns8	1378	13	Chagas	Chagas	NNP
cord-023168-cd7adns8	1378	14	disease	disease	NN
cord-023168-cd7adns8	1378	15	is	be	VBZ
cord-023168-cd7adns8	1378	16	variable	variable	JJ
cord-023168-cd7adns8	1378	17	and	and	CC
cord-023168-cd7adns8	1378	18	the	the	DT
cord-023168-cd7adns8	1378	19	decision	decision	NN
cord-023168-cd7adns8	1378	20	to	to	TO
cord-023168-cd7adns8	1378	21	introduce	introduce	VB
cord-023168-cd7adns8	1378	22	donor	donor	NN
cord-023168-cd7adns8	1378	23	screening	screening	NN
cord-023168-cd7adns8	1378	24	for	for	IN
cord-023168-cd7adns8	1378	25	these	these	DT
cord-023168-cd7adns8	1378	26	infections	infection	NNS
cord-023168-cd7adns8	1378	27	should	should	MD
cord-023168-cd7adns8	1378	28	be	be	VB
cord-023168-cd7adns8	1378	29	based	base	VBN
cord-023168-cd7adns8	1378	30	on	on	IN
cord-023168-cd7adns8	1378	31	local	local	JJ
cord-023168-cd7adns8	1378	32	assessments	assessment	NNS
cord-023168-cd7adns8	1378	33	of	of	IN
cord-023168-cd7adns8	1378	34	the	the	DT
cord-023168-cd7adns8	1378	35	risks	risk	NNS
cord-023168-cd7adns8	1378	36	,	,	,
cord-023168-cd7adns8	1378	37	benefits	benefit	NNS
cord-023168-cd7adns8	1378	38	,	,	,
cord-023168-cd7adns8	1378	39	feasibility	feasibility	NN
cord-023168-cd7adns8	1378	40	and	and	CC
cord-023168-cd7adns8	1378	41	costs	cost	NNS
cord-023168-cd7adns8	1378	42	.	.	.
cord-023168-cd7adns8	1379	1	Blood	blood	NN
cord-023168-cd7adns8	1379	2	should	should	MD
cord-023168-cd7adns8	1379	3	not	not	RB
cord-023168-cd7adns8	1379	4	be	be	VB
cord-023168-cd7adns8	1379	5	separated	separate	VBN
cord-023168-cd7adns8	1379	6	into	into	IN
cord-023168-cd7adns8	1379	7	components	component	NNS
cord-023168-cd7adns8	1379	8	if	if	IN
cord-023168-cd7adns8	1379	9	the	the	DT
cord-023168-cd7adns8	1379	10	residual	residual	JJ
cord-023168-cd7adns8	1379	11	risk	risk	NN
cord-023168-cd7adns8	1379	12	of	of	IN
cord-023168-cd7adns8	1379	13	infection	infection	NN
cord-023168-cd7adns8	1379	14	is	be	VBZ
cord-023168-cd7adns8	1379	15	high	high	JJ
cord-023168-cd7adns8	1379	16	,	,	,
cord-023168-cd7adns8	1379	17	as	as	IN
cord-023168-cd7adns8	1379	18	this	this	DT
cord-023168-cd7adns8	1379	19	will	will	MD
cord-023168-cd7adns8	1379	20	increase	increase	VB
cord-023168-cd7adns8	1379	21	the	the	DT
cord-023168-cd7adns8	1379	22	number	number	NN
cord-023168-cd7adns8	1379	23	of	of	IN
cord-023168-cd7adns8	1379	24	potentially	potentially	RB
cord-023168-cd7adns8	1379	25	infected	infect	VBN
cord-023168-cd7adns8	1379	26	recipients	recipient	NNS
cord-023168-cd7adns8	1379	27	.	.	.
cord-023168-cd7adns8	1380	1	A	a	DT
cord-023168-cd7adns8	1380	2	unit	unit	NN
cord-023168-cd7adns8	1380	3	of	of	IN
cord-023168-cd7adns8	1380	4	blood	blood	NN
cord-023168-cd7adns8	1380	5	is	be	VBZ
cord-023168-cd7adns8	1380	6	usually	usually	RB
cord-023168-cd7adns8	1380	7	stored	store	VBN
cord-023168-cd7adns8	1380	8	until	until	IN
cord-023168-cd7adns8	1380	9	screening	screening	NN
cord-023168-cd7adns8	1380	10	tests	test	NNS
cord-023168-cd7adns8	1380	11	for	for	IN
cord-023168-cd7adns8	1380	12	infections	infection	NNS
cord-023168-cd7adns8	1380	13	have	have	VBP
cord-023168-cd7adns8	1380	14	been	be	VBN
cord-023168-cd7adns8	1380	15	completed	complete	VBN
cord-023168-cd7adns8	1380	16	.	.	.
cord-023168-cd7adns8	1381	1	This	this	DT
cord-023168-cd7adns8	1381	2	means	mean	VBZ
cord-023168-cd7adns8	1381	3	that	that	IN
cord-023168-cd7adns8	1381	4	potentially	potentially	RB
cord-023168-cd7adns8	1381	5	infected	infect	VBN
cord-023168-cd7adns8	1381	6	blood	blood	NN
cord-023168-cd7adns8	1381	7	may	may	MD
cord-023168-cd7adns8	1381	8	be	be	VB
cord-023168-cd7adns8	1381	9	mixed	mix	VBN
cord-023168-cd7adns8	1381	10	up	up	RP
cord-023168-cd7adns8	1381	11	with	with	IN
cord-023168-cd7adns8	1381	12	units	unit	NNS
cord-023168-cd7adns8	1381	13	that	that	WDT
cord-023168-cd7adns8	1381	14	have	have	VBP
cord-023168-cd7adns8	1381	15	already	already	RB
cord-023168-cd7adns8	1381	16	been	be	VBN
cord-023168-cd7adns8	1381	17	screened	screen	VBN
cord-023168-cd7adns8	1381	18	,	,	,
cord-023168-cd7adns8	1381	19	and	and	CC
cord-023168-cd7adns8	1381	20	costly	costly	JJ
cord-023168-cd7adns8	1381	21	blood	blood	NN
cord-023168-cd7adns8	1381	22	collection	collection	NN
cord-023168-cd7adns8	1381	23	bags	bag	NNS
cord-023168-cd7adns8	1381	24	are	be	VBP
cord-023168-cd7adns8	1381	25	wasted	waste	VBN
cord-023168-cd7adns8	1381	26	.	.	.
cord-023168-cd7adns8	1382	1	Screening	screen	VBG
cord-023168-cd7adns8	1382	2	potential	potential	JJ
cord-023168-cd7adns8	1382	3	donors	donor	NNS
cord-023168-cd7adns8	1382	4	before	before	IN
cord-023168-cd7adns8	1382	5	venesecting	venesect	VBG
cord-023168-cd7adns8	1382	6	a	a	DT
cord-023168-cd7adns8	1382	7	unit	unit	NN
cord-023168-cd7adns8	1382	8	of	of	IN
cord-023168-cd7adns8	1382	9	blood	blood	NN
cord-023168-cd7adns8	1382	10	may	may	MD
cord-023168-cd7adns8	1382	11	therefore	therefore	RB
cord-023168-cd7adns8	1382	12	be	be	VB
cord-023168-cd7adns8	1382	13	a	a	DT
cord-023168-cd7adns8	1382	14	more	more	RBR
cord-023168-cd7adns8	1382	15	cost	cost	NN
cord-023168-cd7adns8	1382	16	-	-	HYPH
cord-023168-cd7adns8	1382	17	effective	effective	JJ
cord-023168-cd7adns8	1382	18	way	way	NN
cord-023168-cd7adns8	1382	19	of	of	IN
cord-023168-cd7adns8	1382	20	ensuring	ensure	VBG
cord-023168-cd7adns8	1382	21	safe	safe	JJ
cord-023168-cd7adns8	1382	22	blood	blood	NN
cord-023168-cd7adns8	1382	23	.	.	.
cord-023168-cd7adns8	1383	1	345	345	CD
cord-023168-cd7adns8	1383	2	Tests	test	NNS
cord-023168-cd7adns8	1383	3	for	for	IN
cord-023168-cd7adns8	1383	4	screening	screen	VBG
cord-023168-cd7adns8	1383	5	blood	blood	NN
cord-023168-cd7adns8	1383	6	donors	donor	NNS
cord-023168-cd7adns8	1383	7	need	need	VBP
cord-023168-cd7adns8	1383	8	to	to	TO
cord-023168-cd7adns8	1383	9	be	be	VB
cord-023168-cd7adns8	1383	10	highly	highly	RB
cord-023168-cd7adns8	1383	11	sensitive	sensitive	JJ
cord-023168-cd7adns8	1383	12	,	,	,
cord-023168-cd7adns8	1383	13	and	and	CC
cord-023168-cd7adns8	1383	14	infected	infected	JJ
cord-023168-cd7adns8	1383	15	blood	blood	NN
cord-023168-cd7adns8	1383	16	should	should	MD
cord-023168-cd7adns8	1383	17	be	be	VB
cord-023168-cd7adns8	1383	18	rejected	reject	VBN
cord-023168-cd7adns8	1383	19	.	.	.
cord-023168-cd7adns8	1384	1	Before	before	IN
cord-023168-cd7adns8	1384	2	informing	inform	VBG
cord-023168-cd7adns8	1384	3	the	the	DT
cord-023168-cd7adns8	1384	4	donor	donor	NN
cord-023168-cd7adns8	1384	5	of	of	IN
cord-023168-cd7adns8	1384	6	the	the	DT
cord-023168-cd7adns8	1384	7	outcome	outcome	NN
cord-023168-cd7adns8	1384	8	,	,	,
cord-023168-cd7adns8	1384	9	all	all	DT
cord-023168-cd7adns8	1384	10	positive	positive	JJ
cord-023168-cd7adns8	1384	11	results	result	NNS
cord-023168-cd7adns8	1384	12	should	should	MD
cord-023168-cd7adns8	1384	13	be	be	VB
cord-023168-cd7adns8	1384	14	confirmed	confirm	VBN
cord-023168-cd7adns8	1384	15	using	use	VBG
cord-023168-cd7adns8	1384	16	a	a	DT
cord-023168-cd7adns8	1384	17	test	test	NN
cord-023168-cd7adns8	1384	18	with	with	IN
cord-023168-cd7adns8	1384	19	a	a	DT
cord-023168-cd7adns8	1384	20	high	high	JJ
cord-023168-cd7adns8	1384	21	degree	degree	NN
cord-023168-cd7adns8	1384	22	of	of	IN
cord-023168-cd7adns8	1384	23	specificity	specificity	NN
cord-023168-cd7adns8	1384	24	.	.	.
cord-023168-cd7adns8	1385	1	Where	where	WRB
cord-023168-cd7adns8	1385	2	blood	blood	NN
cord-023168-cd7adns8	1385	3	or	or	CC
cord-023168-cd7adns8	1385	4	that	that	IN
cord-023168-cd7adns8	1385	5	the	the	DT
cord-023168-cd7adns8	1385	6	blood	blood	NN
cord-023168-cd7adns8	1385	7	may	may	MD
cord-023168-cd7adns8	1385	8	become	become	VB
cord-023168-cd7adns8	1385	9	infected	infect	VBN
cord-023168-cd7adns8	1385	10	with	with	IN
cord-023168-cd7adns8	1385	11	bacteria	bacteria	NNS
cord-023168-cd7adns8	1385	12	during	during	IN
cord-023168-cd7adns8	1385	13	the	the	DT
cord-023168-cd7adns8	1385	14	process	process	NN
cord-023168-cd7adns8	1385	15	.	.	.
cord-023168-cd7adns8	1386	1	Intraoperative	Intraoperative	NNP
cord-023168-cd7adns8	1386	2	Blood	Blood	NNP
cord-023168-cd7adns8	1386	3	Salvage	Salvage	NNP
cord-023168-cd7adns8	1386	4	.	.	.
cord-023168-cd7adns8	1387	1	This	this	DT
cord-023168-cd7adns8	1387	2	involves	involve	VBZ
cord-023168-cd7adns8	1387	3	collecting	collect	VBG
cord-023168-cd7adns8	1387	4	blood	blood	NN
cord-023168-cd7adns8	1387	5	lost	lose	VBN
cord-023168-cd7adns8	1387	6	during	during	IN
cord-023168-cd7adns8	1387	7	the	the	DT
cord-023168-cd7adns8	1387	8	operation	operation	NN
cord-023168-cd7adns8	1387	9	and	and	CC
cord-023168-cd7adns8	1387	10	reinfusing	reinfuse	VBG
cord-023168-cd7adns8	1387	11	it	-PRON-	PRP
cord-023168-cd7adns8	1387	12	into	into	IN
cord-023168-cd7adns8	1387	13	the	the	DT
cord-023168-cd7adns8	1387	14	patient	patient	NN
cord-023168-cd7adns8	1387	15	either	either	CC
cord-023168-cd7adns8	1387	16	during	during	IN
cord-023168-cd7adns8	1387	17	or	or	CC
cord-023168-cd7adns8	1387	18	after	after	IN
cord-023168-cd7adns8	1387	19	surgery	surgery	NN
cord-023168-cd7adns8	1387	20	.	.	.
cord-023168-cd7adns8	1388	1	Although	although	IN
cord-023168-cd7adns8	1388	2	this	this	DT
cord-023168-cd7adns8	1388	3	technique	technique	NN
cord-023168-cd7adns8	1388	4	is	be	VBZ
cord-023168-cd7adns8	1388	5	practical	practical	JJ
cord-023168-cd7adns8	1388	6	and	and	CC
cord-023168-cd7adns8	1388	7	safe	safe	JJ
cord-023168-cd7adns8	1388	8	,	,	,
cord-023168-cd7adns8	1388	9	and	and	CC
cord-023168-cd7adns8	1388	10	reduces	reduce	VBZ
cord-023168-cd7adns8	1388	11	the	the	DT
cord-023168-cd7adns8	1388	12	need	need	NN
cord-023168-cd7adns8	1388	13	for	for	IN
cord-023168-cd7adns8	1388	14	donor	donor	NN
cord-023168-cd7adns8	1388	15	blood	blood	NN
cord-023168-cd7adns8	1388	16	by	by	IN
cord-023168-cd7adns8	1388	17	27	27	CD
cord-023168-cd7adns8	1388	18	-	-	SYM
cord-023168-cd7adns8	1388	19	53	53	CD
cord-023168-cd7adns8	1388	20	%	%	NN
cord-023168-cd7adns8	1388	21	,	,	,
cord-023168-cd7adns8	1388	22	355	355	CD
cord-023168-cd7adns8	1388	23	it	-PRON-	PRP
cord-023168-cd7adns8	1388	24	requires	require	VBZ
cord-023168-cd7adns8	1388	25	specialized	specialized	JJ
cord-023168-cd7adns8	1388	26	equipment	equipment	NN
cord-023168-cd7adns8	1388	27	and	and	CC
cord-023168-cd7adns8	1388	28	training	training	NN
cord-023168-cd7adns8	1388	29	,	,	,
cord-023168-cd7adns8	1388	30	and	and	CC
cord-023168-cd7adns8	1388	31	may	may	MD
cord-023168-cd7adns8	1388	32	be	be	VB
cord-023168-cd7adns8	1388	33	more	more	RBR
cord-023168-cd7adns8	1388	34	expensive	expensive	JJ
cord-023168-cd7adns8	1388	35	than	than	IN
cord-023168-cd7adns8	1388	36	routinely	routinely	RB
cord-023168-cd7adns8	1388	37	donated	donate	VBN
cord-023168-cd7adns8	1388	38	blood	blood	NN
cord-023168-cd7adns8	1388	39	.	.	.
cord-023168-cd7adns8	1389	1	356	356	CD
cord-023168-cd7adns8	1390	1	Other	other	JJ
cord-023168-cd7adns8	1390	2	Measures	measure	NNS
cord-023168-cd7adns8	1390	3	.	.	.
cord-023168-cd7adns8	1391	1	Normal	normal	JJ
cord-023168-cd7adns8	1391	2	saline	saline	NN
cord-023168-cd7adns8	1391	3	or	or	CC
cord-023168-cd7adns8	1391	4	intravenous	intravenous	JJ
cord-023168-cd7adns8	1391	5	replacement	replacement	NN
cord-023168-cd7adns8	1391	6	fluids	fluid	NNS
cord-023168-cd7adns8	1391	7	can	can	MD
cord-023168-cd7adns8	1391	8	be	be	VB
cord-023168-cd7adns8	1391	9	used	use	VBN
cord-023168-cd7adns8	1391	10	judiciously	judiciously	RB
cord-023168-cd7adns8	1391	11	in	in	IN
cord-023168-cd7adns8	1391	12	acute	acute	JJ
cord-023168-cd7adns8	1391	13	blood	blood	NN
cord-023168-cd7adns8	1391	14	loss	loss	NN
cord-023168-cd7adns8	1391	15	,	,	,
cord-023168-cd7adns8	1391	16	and	and	CC
cord-023168-cd7adns8	1391	17	in	in	IN
cord-023168-cd7adns8	1391	18	certain	certain	JJ
cord-023168-cd7adns8	1391	19	circumstances	circumstance	NNS
cord-023168-cd7adns8	1391	20	may	may	MD
cord-023168-cd7adns8	1391	21	be	be	VB
cord-023168-cd7adns8	1391	22	as	as	RB
cord-023168-cd7adns8	1391	23	effective	effective	JJ
cord-023168-cd7adns8	1391	24	as	as	IN
cord-023168-cd7adns8	1391	25	whole	whole	JJ
cord-023168-cd7adns8	1391	26	blood	blood	NN
cord-023168-cd7adns8	1391	27	,	,	,
cord-023168-cd7adns8	1391	28	red	red	JJ
cord-023168-cd7adns8	1391	29	cells	cell	NNS
cord-023168-cd7adns8	1391	30	or	or	CC
cord-023168-cd7adns8	1391	31	plasma	plasma	NN
cord-023168-cd7adns8	1391	32	.	.	.
cord-023168-cd7adns8	1392	1	Erythropoietin	erythropoietin	NN
cord-023168-cd7adns8	1392	2	,	,	,
cord-023168-cd7adns8	1392	3	which	which	WDT
cord-023168-cd7adns8	1392	4	stimulates	stimulate	VBZ
cord-023168-cd7adns8	1392	5	endogenous	endogenous	JJ
cord-023168-cd7adns8	1392	6	red	red	JJ
cord-023168-cd7adns8	1392	7	cell	cell	NN
cord-023168-cd7adns8	1392	8	production	production	NN
cord-023168-cd7adns8	1392	9	is	be	VBZ
cord-023168-cd7adns8	1392	10	well	well	RB
cord-023168-cd7adns8	1392	11	-	-	HYPH
cord-023168-cd7adns8	1392	12	established	establish	VBN
cord-023168-cd7adns8	1392	13	for	for	IN
cord-023168-cd7adns8	1392	14	use	use	NN
cord-023168-cd7adns8	1392	15	in	in	IN
cord-023168-cd7adns8	1392	16	chronic	chronic	JJ
cord-023168-cd7adns8	1392	17	anaemias	anaemia	NNS
cord-023168-cd7adns8	1392	18	such	such	JJ
cord-023168-cd7adns8	1392	19	as	as	IN
cord-023168-cd7adns8	1392	20	those	those	DT
cord-023168-cd7adns8	1392	21	due	due	JJ
cord-023168-cd7adns8	1392	22	to	to	IN
cord-023168-cd7adns8	1392	23	renal	renal	JJ
cord-023168-cd7adns8	1392	24	failure	failure	NN
cord-023168-cd7adns8	1392	25	,	,	,
cord-023168-cd7adns8	1392	26	cancer	cancer	NN
cord-023168-cd7adns8	1392	27	and	and	CC
cord-023168-cd7adns8	1392	28	HIV	HIV	NNP
cord-023168-cd7adns8	1392	29	infection	infection	NN
cord-023168-cd7adns8	1392	30	but	but	CC
cord-023168-cd7adns8	1392	31	its	-PRON-	PRP$
cord-023168-cd7adns8	1392	32	delayed	delay	VBN
cord-023168-cd7adns8	1392	33	action	action	NN
cord-023168-cd7adns8	1392	34	makes	make	VBZ
cord-023168-cd7adns8	1392	35	it	-PRON-	PRP
cord-023168-cd7adns8	1392	36	unsuitable	unsuitable	JJ
cord-023168-cd7adns8	1392	37	for	for	IN
cord-023168-cd7adns8	1392	38	use	use	NN
cord-023168-cd7adns8	1392	39	in	in	IN
cord-023168-cd7adns8	1392	40	acute	acute	JJ
cord-023168-cd7adns8	1392	41	anaemias	anaemia	NNS
cord-023168-cd7adns8	1392	42	.	.	.
cord-023168-cd7adns8	1393	1	Synthetic	synthetic	JJ
cord-023168-cd7adns8	1393	2	oxygen	oxygen	NN
cord-023168-cd7adns8	1393	3	carriers	carrier	NNS
cord-023168-cd7adns8	1393	4	,	,	,
cord-023168-cd7adns8	1393	5	such	such	JJ
cord-023168-cd7adns8	1393	6	as	as	IN
cord-023168-cd7adns8	1393	7	perfluorocarbons	perfluorocarbon	NNS
cord-023168-cd7adns8	1393	8	,	,	,
cord-023168-cd7adns8	1393	9	are	be	VBP
cord-023168-cd7adns8	1393	10	not	not	RB
cord-023168-cd7adns8	1393	11	yet	yet	RB
cord-023168-cd7adns8	1393	12	routinely	routinely	RB
cord-023168-cd7adns8	1393	13	available	available	JJ
cord-023168-cd7adns8	1393	14	.	.	.
cord-023168-cd7adns8	1394	1	357	357	CD
cord-023168-cd7adns8	1394	2	 	 	_SP
cord-023168-cd7adns8	1395	1	In	in	IN
cord-023168-cd7adns8	1395	2	low	low	JJ
cord-023168-cd7adns8	1395	3	-	-	HYPH
cord-023168-cd7adns8	1395	4	income	income	NN
cord-023168-cd7adns8	1395	5	countries	country	NNS
cord-023168-cd7adns8	1395	6	,	,	,
cord-023168-cd7adns8	1395	7	the	the	DT
cord-023168-cd7adns8	1395	8	recommended	recommend	VBN
cord-023168-cd7adns8	1395	9	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1395	10	threshold	threshold	NN
cord-023168-cd7adns8	1395	11	for	for	IN
cord-023168-cd7adns8	1395	12	transfusions	transfusion	NNS
cord-023168-cd7adns8	1395	13	is	be	VBZ
cord-023168-cd7adns8	1395	14	often	often	RB
cord-023168-cd7adns8	1395	15	well	well	RB
cord-023168-cd7adns8	1395	16	below	below	IN
cord-023168-cd7adns8	1395	17	that	that	DT
cord-023168-cd7adns8	1396	1	which	which	WDT
cord-023168-cd7adns8	1396	2	would	would	MD
cord-023168-cd7adns8	1396	3	be	be	VB
cord-023168-cd7adns8	1396	4	accepted	accept	VBN
cord-023168-cd7adns8	1396	5	in	in	IN
cord-023168-cd7adns8	1396	6	more	more	RBR
cord-023168-cd7adns8	1396	7	wealthy	wealthy	JJ
cord-023168-cd7adns8	1396	8	countries	country	NNS
cord-023168-cd7adns8	1396	9	.	.	.
cord-023168-cd7adns8	1397	1	Randomized	randomized	JJ
cord-023168-cd7adns8	1397	2	controlled	control	VBN
cord-023168-cd7adns8	1397	3	studies	study	NNS
cord-023168-cd7adns8	1397	4	in	in	IN
cord-023168-cd7adns8	1397	5	wealthy	wealthy	JJ
cord-023168-cd7adns8	1397	6	countries	country	NNS
cord-023168-cd7adns8	1397	7	indicate	indicate	VBP
cord-023168-cd7adns8	1397	8	that	that	IN
cord-023168-cd7adns8	1397	9	for	for	IN
cord-023168-cd7adns8	1397	10	most	most	JJS
cord-023168-cd7adns8	1397	11	adults	adult	NNS
cord-023168-cd7adns8	1397	12	and	and	CC
cord-023168-cd7adns8	1397	13	children	child	NNS
cord-023168-cd7adns8	1397	14	undergoing	undergo	VBG
cord-023168-cd7adns8	1397	15	critical	critical	JJ
cord-023168-cd7adns8	1397	16	care	care	NN
cord-023168-cd7adns8	1397	17	,	,	,
cord-023168-cd7adns8	1397	18	a	a	DT
cord-023168-cd7adns8	1397	19	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1397	20	threshold	threshold	NN
cord-023168-cd7adns8	1397	21	of	of	IN
cord-023168-cd7adns8	1397	22	70	70	CD
cord-023168-cd7adns8	1397	23	g	g	NN
cord-023168-cd7adns8	1397	24	/	/	SYM
cord-023168-cd7adns8	1397	25	L	l	NN
cord-023168-cd7adns8	1397	26	for	for	IN
cord-023168-cd7adns8	1397	27	transfusion	transfusion	NN
cord-023168-cd7adns8	1397	28	is	be	VBZ
cord-023168-cd7adns8	1397	29	safe	safe	JJ
cord-023168-cd7adns8	1397	30	358	358	CD
cord-023168-cd7adns8	1397	31	whereas	whereas	IN
cord-023168-cd7adns8	1397	32	paediatric	paediatric	JJ
cord-023168-cd7adns8	1397	33	blood	blood	NN
cord-023168-cd7adns8	1397	34	transfusion	transfusion	NN
cord-023168-cd7adns8	1397	35	protocols	protocol	NNS
cord-023168-cd7adns8	1397	36	in	in	IN
cord-023168-cd7adns8	1397	37	sub	sub	JJ
cord-023168-cd7adns8	1397	38	-	-	JJ
cord-023168-cd7adns8	1397	39	Saharan	Saharan	NNP
cord-023168-cd7adns8	1397	40	Africa	Africa	NNP
cord-023168-cd7adns8	1397	41	often	often	RB
cord-023168-cd7adns8	1397	42	recommend	recommend	VBP
cord-023168-cd7adns8	1397	43	transfusions	transfusion	NNS
cord-023168-cd7adns8	1397	44	for	for	IN
cord-023168-cd7adns8	1397	45	stable	stable	JJ
cord-023168-cd7adns8	1397	46	children	child	NNS
cord-023168-cd7adns8	1397	47	only	only	RB
cord-023168-cd7adns8	1397	48	when	when	WRB
cord-023168-cd7adns8	1397	49	the	the	DT
cord-023168-cd7adns8	1397	50	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1397	51	level	level	NN
cord-023168-cd7adns8	1397	52	is	be	VBZ
cord-023168-cd7adns8	1397	53	less	less	JJR
cord-023168-cd7adns8	1397	54	than	than	IN
cord-023168-cd7adns8	1397	55	40	40	CD
cord-023168-cd7adns8	1397	56	g	g	NN
cord-023168-cd7adns8	1397	57	/	/	SYM
cord-023168-cd7adns8	1397	58	L.	L.	NNP
cord-023168-cd7adns8	1397	59	351	351	CD
cord-023168-cd7adns8	1397	60	Complications	complication	NNS
cord-023168-cd7adns8	1397	61	such	such	JJ
cord-023168-cd7adns8	1397	62	as	as	IN
cord-023168-cd7adns8	1397	63	cardiac	cardiac	JJ
cord-023168-cd7adns8	1397	64	failure	failure	NN
cord-023168-cd7adns8	1397	65	or	or	CC
cord-023168-cd7adns8	1397	66	infection	infection	NN
cord-023168-cd7adns8	1397	67	may	may	MD
cord-023168-cd7adns8	1397	68	necessitate	necessitate	VB
cord-023168-cd7adns8	1397	69	transfusion	transfusion	NN
cord-023168-cd7adns8	1397	70	at	at	IN
cord-023168-cd7adns8	1397	71	a	a	DT
cord-023168-cd7adns8	1397	72	higher	high	JJR
cord-023168-cd7adns8	1397	73	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1397	74	level	level	NN
cord-023168-cd7adns8	1397	75	.	.	.
cord-023168-cd7adns8	1398	1	Transfusion	transfusion	NN
cord-023168-cd7adns8	1398	2	should	should	MD
cord-023168-cd7adns8	1398	3	be	be	VB
cord-023168-cd7adns8	1398	4	combined	combine	VBN
cord-023168-cd7adns8	1398	5	with	with	IN
cord-023168-cd7adns8	1398	6	adequate	adequate	JJ
cord-023168-cd7adns8	1398	7	haematinic	haematinic	JJ
cord-023168-cd7adns8	1398	8	replacements	replacement	NNS
cord-023168-cd7adns8	1398	9	and	and	CC
cord-023168-cd7adns8	1398	10	underlying	underlying	JJ
cord-023168-cd7adns8	1398	11	conditions	condition	NNS
cord-023168-cd7adns8	1398	12	should	should	MD
cord-023168-cd7adns8	1398	13	be	be	VB
cord-023168-cd7adns8	1398	14	treated	treat	VBN
cord-023168-cd7adns8	1398	15	.	.	.
cord-023168-cd7adns8	1399	1	359	359	CD
cord-023168-cd7adns8	1399	2	Early	early	JJ
cord-023168-cd7adns8	1399	3	evidence	evidence	NN
cord-023168-cd7adns8	1399	4	suggests	suggest	VBZ
cord-023168-cd7adns8	1399	5	that	that	IN
cord-023168-cd7adns8	1399	6	intermittent	intermittent	JJ
cord-023168-cd7adns8	1399	7	preventive	preventive	JJ
cord-023168-cd7adns8	1399	8	treatment	treatment	NN
cord-023168-cd7adns8	1399	9	with	with	IN
cord-023168-cd7adns8	1399	10	anti	anti	JJ
cord-023168-cd7adns8	1399	11	-	-	NNS
cord-023168-cd7adns8	1399	12	malarials	malarial	NNS
cord-023168-cd7adns8	1399	13	may	may	MD
cord-023168-cd7adns8	1399	14	reduce	reduce	VB
cord-023168-cd7adns8	1399	15	the	the	DT
cord-023168-cd7adns8	1399	16	high	high	JJ
cord-023168-cd7adns8	1399	17	hospital	hospital	NN
cord-023168-cd7adns8	1399	18	readmission	readmission	NN
cord-023168-cd7adns8	1399	19	rates	rate	NNS
cord-023168-cd7adns8	1399	20	experienced	experience	VBN
cord-023168-cd7adns8	1399	21	by	by	IN
cord-023168-cd7adns8	1399	22	children	child	NNS
cord-023168-cd7adns8	1399	23	post	post	NN
cord-023168-cd7adns8	1399	24	-	-	NN
cord-023168-cd7adns8	1399	25	transfusion	transfusion	NN
cord-023168-cd7adns8	1399	26	.	.	.
cord-023168-cd7adns8	1400	1	360	360	CD
cord-023168-cd7adns8	1400	2	 	 	_SP
cord-023168-cd7adns8	1400	3	Complications	complication	NNS
cord-023168-cd7adns8	1400	4	can	can	MD
cord-023168-cd7adns8	1400	5	occur	occur	VB
cord-023168-cd7adns8	1400	6	immediately	immediately	RB
cord-023168-cd7adns8	1400	7	during	during	IN
cord-023168-cd7adns8	1400	8	transfusion	transfusion	NN
cord-023168-cd7adns8	1400	9	,	,	,
cord-023168-cd7adns8	1400	10	within	within	IN
cord-023168-cd7adns8	1400	11	a	a	DT
cord-023168-cd7adns8	1400	12	few	few	JJ
cord-023168-cd7adns8	1400	13	hours	hour	NNS
cord-023168-cd7adns8	1400	14	of	of	IN
cord-023168-cd7adns8	1400	15	its	-PRON-	PRP$
cord-023168-cd7adns8	1400	16	completion	completion	NN
cord-023168-cd7adns8	1400	17	,	,	,
cord-023168-cd7adns8	1400	18	or	or	CC
cord-023168-cd7adns8	1400	19	be	be	VB
cord-023168-cd7adns8	1400	20	delayed	delay	VBN
cord-023168-cd7adns8	1400	21	for	for	IN
cord-023168-cd7adns8	1400	22	many	many	JJ
cord-023168-cd7adns8	1400	23	years	year	NNS
cord-023168-cd7adns8	1400	24	,	,	,
cord-023168-cd7adns8	1400	25	as	as	IN
cord-023168-cd7adns8	1400	26	in	in	IN
cord-023168-cd7adns8	1400	27	the	the	DT
cord-023168-cd7adns8	1400	28	case	case	NN
cord-023168-cd7adns8	1400	29	of	of	IN
cord-023168-cd7adns8	1400	30	viral	viral	JJ
cord-023168-cd7adns8	1400	31	infections	infection	NNS
cord-023168-cd7adns8	1400	32	(	(	-LRB-
cord-023168-cd7adns8	1400	33	Box	Box	NNP
cord-023168-cd7adns8	1400	34	65.24	65.24	CD
cord-023168-cd7adns8	1400	35	)	)	-RRB-
cord-023168-cd7adns8	1400	36	.	.	.
cord-023168-cd7adns8	1401	1	measurements	measurement	NNS
cord-023168-cd7adns8	1401	2	.	.	.
cord-023168-cd7adns8	1402	1	When	when	WRB
cord-023168-cd7adns8	1402	2	they	-PRON-	PRP
cord-023168-cd7adns8	1402	3	doubt	doubt	VBP
cord-023168-cd7adns8	1402	4	the	the	DT
cord-023168-cd7adns8	1402	5	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1402	6	result	result	NN
cord-023168-cd7adns8	1402	7	,	,	,
cord-023168-cd7adns8	1402	8	clinicians	clinician	NNS
cord-023168-cd7adns8	1402	9	rely	rely	VBP
cord-023168-cd7adns8	1402	10	entirely	entirely	RB
cord-023168-cd7adns8	1402	11	on	on	IN
cord-023168-cd7adns8	1402	12	clinical	clinical	JJ
cord-023168-cd7adns8	1402	13	judgement	judgement	NN
cord-023168-cd7adns8	1402	14	to	to	TO
cord-023168-cd7adns8	1402	15	guide	guide	VB
cord-023168-cd7adns8	1402	16	transfusion	transfusion	NN
cord-023168-cd7adns8	1402	17	practice	practice	NN
cord-023168-cd7adns8	1402	18	which	which	WDT
cord-023168-cd7adns8	1402	19	can	can	MD
cord-023168-cd7adns8	1402	20	lead	lead	VB
cord-023168-cd7adns8	1402	21	to	to	IN
cord-023168-cd7adns8	1402	22	significant	significant	JJ
cord-023168-cd7adns8	1402	23	numbers	number	NNS
cord-023168-cd7adns8	1402	24	of	of	IN
cord-023168-cd7adns8	1402	25	inappropriate	inappropriate	JJ
cord-023168-cd7adns8	1402	26	transfusions	transfusion	NNS
cord-023168-cd7adns8	1402	27	.	.	.
cord-023168-cd7adns8	1403	1	353	353	CD
cord-023168-cd7adns8	1404	1	A	a	DT
cord-023168-cd7adns8	1404	2	lack	lack	NN
cord-023168-cd7adns8	1404	3	of	of	IN
cord-023168-cd7adns8	1404	4	investment	investment	NN
cord-023168-cd7adns8	1404	5	in	in	IN
cord-023168-cd7adns8	1404	6	the	the	DT
cord-023168-cd7adns8	1404	7	quality	quality	NN
cord-023168-cd7adns8	1404	8	of	of	IN
cord-023168-cd7adns8	1404	9	a	a	DT
cord-023168-cd7adns8	1404	10	critical	critical	JJ
cord-023168-cd7adns8	1404	11	test	test	NN
cord-023168-cd7adns8	1404	12	,	,	,
cord-023168-cd7adns8	1404	13	such	such	JJ
cord-023168-cd7adns8	1404	14	as	as	IN
cord-023168-cd7adns8	1404	15	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1404	16	measurement	measurement	NN
cord-023168-cd7adns8	1404	17	,	,	,
cord-023168-cd7adns8	1404	18	can	can	MD
cord-023168-cd7adns8	1404	19	waste	waste	VB
cord-023168-cd7adns8	1404	20	significant	significant	JJ
cord-023168-cd7adns8	1404	21	resources	resource	NNS
cord-023168-cd7adns8	1404	22	downstream	downstream	RB
cord-023168-cd7adns8	1404	23	in	in	IN
cord-023168-cd7adns8	1404	24	the	the	DT
cord-023168-cd7adns8	1404	25	transfusion	transfusion	NN
cord-023168-cd7adns8	1404	26	process	process	NN
cord-023168-cd7adns8	1404	27	,	,	,
cord-023168-cd7adns8	1404	28	and	and	CC
cord-023168-cd7adns8	1404	29	unnecessarily	unnecessarily	RB
cord-023168-cd7adns8	1404	30	expose	expose	VB
cord-023168-cd7adns8	1404	31	recipients	recipient	NNS
cord-023168-cd7adns8	1404	32	to	to	IN
cord-023168-cd7adns8	1404	33	the	the	DT
cord-023168-cd7adns8	1404	34	risk	risk	NN
cord-023168-cd7adns8	1404	35	of	of	IN
cord-023168-cd7adns8	1404	36	transfusion	transfusion	NN
cord-023168-cd7adns8	1404	37	-	-	HYPH
cord-023168-cd7adns8	1404	38	related	relate	VBN
cord-023168-cd7adns8	1404	39	infections	infection	NNS
cord-023168-cd7adns8	1404	40	.	.	.
cord-023168-cd7adns8	1405	1	Minimizing	minimize	VBG
cord-023168-cd7adns8	1405	2	Surgical	surgical	JJ
cord-023168-cd7adns8	1405	3	Blood	blood	NN
cord-023168-cd7adns8	1405	4	Loss	loss	NN
cord-023168-cd7adns8	1405	5	.	.	.
cord-023168-cd7adns8	1406	1	Where	where	WRB
cord-023168-cd7adns8	1406	2	blood	blood	NN
cord-023168-cd7adns8	1406	3	is	be	VBZ
cord-023168-cd7adns8	1406	4	in	in	IN
cord-023168-cd7adns8	1406	5	short	short	JJ
cord-023168-cd7adns8	1406	6	supply	supply	NN
cord-023168-cd7adns8	1406	7	,	,	,
cord-023168-cd7adns8	1406	8	it	-PRON-	PRP
cord-023168-cd7adns8	1406	9	is	be	VBZ
cord-023168-cd7adns8	1406	10	particularly	particularly	RB
cord-023168-cd7adns8	1406	11	important	important	JJ
cord-023168-cd7adns8	1406	12	to	to	TO
cord-023168-cd7adns8	1406	13	ensure	ensure	VB
cord-023168-cd7adns8	1406	14	that	that	IN
cord-023168-cd7adns8	1406	15	the	the	DT
cord-023168-cd7adns8	1406	16	best	good	JJS
cord-023168-cd7adns8	1406	17	anaesthetic	anaesthetic	JJ
cord-023168-cd7adns8	1406	18	and	and	CC
cord-023168-cd7adns8	1406	19	surgical	surgical	JJ
cord-023168-cd7adns8	1406	20	techniques	technique	NNS
cord-023168-cd7adns8	1406	21	are	be	VBP
cord-023168-cd7adns8	1406	22	used	use	VBN
cord-023168-cd7adns8	1406	23	,	,	,
cord-023168-cd7adns8	1406	24	to	to	TO
cord-023168-cd7adns8	1406	25	minimize	minimize	VB
cord-023168-cd7adns8	1406	26	blood	blood	NN
cord-023168-cd7adns8	1406	27	loss	loss	NN
cord-023168-cd7adns8	1406	28	during	during	IN
cord-023168-cd7adns8	1406	29	surgery	surgery	NN
cord-023168-cd7adns8	1406	30	.	.	.
cord-023168-cd7adns8	1407	1	Drugs	drug	NNS
cord-023168-cd7adns8	1407	2	which	which	WDT
cord-023168-cd7adns8	1407	3	improve	improve	VBP
cord-023168-cd7adns8	1407	4	haemostasis	haemostasis	NN
cord-023168-cd7adns8	1407	5	or	or	CC
cord-023168-cd7adns8	1407	6	reduce	reduce	VB
cord-023168-cd7adns8	1407	7	fibrinolysis	fibrinolysis	NN
cord-023168-cd7adns8	1407	8	,	,	,
cord-023168-cd7adns8	1407	9	such	such	JJ
cord-023168-cd7adns8	1407	10	as	as	IN
cord-023168-cd7adns8	1407	11	aprotinin	aprotinin	NNP
cord-023168-cd7adns8	1407	12	and	and	CC
cord-023168-cd7adns8	1407	13	cyklokapron	cyklokapron	NNP
cord-023168-cd7adns8	1407	14	,	,	,
cord-023168-cd7adns8	1407	15	and	and	CC
cord-023168-cd7adns8	1407	16	fibrin	fibrin	NN
cord-023168-cd7adns8	1407	17	sealants	sealant	NNS
cord-023168-cd7adns8	1407	18	,	,	,
cord-023168-cd7adns8	1407	19	can	can	MD
cord-023168-cd7adns8	1407	20	be	be	VB
cord-023168-cd7adns8	1407	21	effective	effective	JJ
cord-023168-cd7adns8	1407	22	in	in	IN
cord-023168-cd7adns8	1407	23	reducing	reduce	VBG
cord-023168-cd7adns8	1407	24	perioperative	perioperative	JJ
cord-023168-cd7adns8	1407	25	blood	blood	NN
cord-023168-cd7adns8	1407	26	loss	loss	NN
cord-023168-cd7adns8	1407	27	.	.	.
cord-023168-cd7adns8	1408	1	These	these	DT
cord-023168-cd7adns8	1408	2	drugs	drug	NNS
cord-023168-cd7adns8	1408	3	can	can	MD
cord-023168-cd7adns8	1408	4	therefore	therefore	RB
cord-023168-cd7adns8	1408	5	reduce	reduce	VB
cord-023168-cd7adns8	1408	6	the	the	DT
cord-023168-cd7adns8	1408	7	need	need	NN
cord-023168-cd7adns8	1408	8	for	for	IN
cord-023168-cd7adns8	1408	9	blood	blood	NN
cord-023168-cd7adns8	1408	10	transfusion	transfusion	NN
cord-023168-cd7adns8	1408	11	but	but	CC
cord-023168-cd7adns8	1408	12	they	-PRON-	PRP
cord-023168-cd7adns8	1408	13	may	may	MD
cord-023168-cd7adns8	1408	14	be	be	VB
cord-023168-cd7adns8	1408	15	too	too	RB
cord-023168-cd7adns8	1408	16	expensive	expensive	JJ
cord-023168-cd7adns8	1408	17	for	for	IN
cord-023168-cd7adns8	1408	18	use	use	NN
cord-023168-cd7adns8	1408	19	in	in	IN
cord-023168-cd7adns8	1408	20	low	low	JJ
cord-023168-cd7adns8	1408	21	-	-	HYPH
cord-023168-cd7adns8	1408	22	income	income	NN
cord-023168-cd7adns8	1408	23	countries	country	NNS
cord-023168-cd7adns8	1408	24	.	.	.
cord-023168-cd7adns8	1409	1	A	a	DT
cord-023168-cd7adns8	1409	2	cost	cost	NN
cord-023168-cd7adns8	1409	3	-	-	HYPH
cord-023168-cd7adns8	1409	4	effectiveness	effectiveness	NN
cord-023168-cd7adns8	1409	5	study	study	NN
cord-023168-cd7adns8	1409	6	of	of	IN
cord-023168-cd7adns8	1409	7	surgical	surgical	JJ
cord-023168-cd7adns8	1409	8	bleeding	bleeding	NN
cord-023168-cd7adns8	1409	9	in	in	IN
cord-023168-cd7adns8	1409	10	four	four	CD
cord-023168-cd7adns8	1409	11	sub	sub	JJ
cord-023168-cd7adns8	1409	12	-	-	JJ
cord-023168-cd7adns8	1409	13	Saharan	saharan	JJ
cord-023168-cd7adns8	1409	14	countries	country	NNS
cord-023168-cd7adns8	1409	15	indicates	indicate	VBZ
cord-023168-cd7adns8	1409	16	that	that	IN
cord-023168-cd7adns8	1409	17	the	the	DT
cord-023168-cd7adns8	1409	18	antifibrinolytic	antifibrinolytic	JJ
cord-023168-cd7adns8	1409	19	,	,	,
cord-023168-cd7adns8	1409	20	tranexamic	tranexamic	JJ
cord-023168-cd7adns8	1409	21	acid	acid	NN
cord-023168-cd7adns8	1409	22	,	,	,
cord-023168-cd7adns8	1409	23	could	could	MD
cord-023168-cd7adns8	1409	24	save	save	VB
cord-023168-cd7adns8	1409	25	lives	life	NNS
cord-023168-cd7adns8	1409	26	in	in	IN
cord-023168-cd7adns8	1409	27	countries	country	NNS
cord-023168-cd7adns8	1409	28	with	with	IN
cord-023168-cd7adns8	1409	29	blood	blood	NN
cord-023168-cd7adns8	1409	30	shortages	shortage	NNS
cord-023168-cd7adns8	1409	31	,	,	,
cord-023168-cd7adns8	1409	32	reduce	reduce	VB
cord-023168-cd7adns8	1409	33	healthcare	healthcare	NN
cord-023168-cd7adns8	1409	34	costs	cost	NNS
cord-023168-cd7adns8	1409	35	and	and	CC
cord-023168-cd7adns8	1409	36	prevent	prevent	VBP
cord-023168-cd7adns8	1409	37	transmission	transmission	NN
cord-023168-cd7adns8	1409	38	of	of	IN
cord-023168-cd7adns8	1409	39	infections	infection	NNS
cord-023168-cd7adns8	1409	40	.	.	.
cord-023168-cd7adns8	1410	1	354	354	CD
cord-023168-cd7adns8	1410	2	Preoperative	Preoperative	NNP
cord-023168-cd7adns8	1410	3	Autologous	Autologous	NNP
cord-023168-cd7adns8	1410	4	Blood	Blood	NNP
cord-023168-cd7adns8	1410	5	Deposit	Deposit	NNP
cord-023168-cd7adns8	1410	6	.	.	.
cord-023168-cd7adns8	1411	1	Patients	patient	NNS
cord-023168-cd7adns8	1411	2	undergoing	undergo	VBG
cord-023168-cd7adns8	1411	3	planned	plan	VBN
cord-023168-cd7adns8	1411	4	surgery	surgery	NN
cord-023168-cd7adns8	1411	5	who	who	WP
cord-023168-cd7adns8	1411	6	are	be	VBP
cord-023168-cd7adns8	1411	7	likely	likely	JJ
cord-023168-cd7adns8	1411	8	to	to	TO
cord-023168-cd7adns8	1411	9	require	require	VB
cord-023168-cd7adns8	1411	10	a	a	DT
cord-023168-cd7adns8	1411	11	blood	blood	NN
cord-023168-cd7adns8	1411	12	transfusion	transfusion	NN
cord-023168-cd7adns8	1411	13	can	can	MD
cord-023168-cd7adns8	1411	14	have	have	VB
cord-023168-cd7adns8	1411	15	units	unit	NNS
cord-023168-cd7adns8	1411	16	of	of	IN
cord-023168-cd7adns8	1411	17	their	-PRON-	PRP$
cord-023168-cd7adns8	1411	18	own	own	JJ
cord-023168-cd7adns8	1411	19	blood	blood	NN
cord-023168-cd7adns8	1411	20	removed	remove	VBN
cord-023168-cd7adns8	1411	21	and	and	CC
cord-023168-cd7adns8	1411	22	stored	store	VBN
cord-023168-cd7adns8	1411	23	in	in	IN
cord-023168-cd7adns8	1411	24	case	case	NN
cord-023168-cd7adns8	1411	25	they	-PRON-	PRP
cord-023168-cd7adns8	1411	26	have	have	VBP
cord-023168-cd7adns8	1411	27	significant	significant	JJ
cord-023168-cd7adns8	1411	28	intraoperative	intraoperative	JJ
cord-023168-cd7adns8	1411	29	blood	blood	NN
cord-023168-cd7adns8	1411	30	loss	loss	NN
cord-023168-cd7adns8	1411	31	and	and	CC
cord-023168-cd7adns8	1411	32	need	need	VB
cord-023168-cd7adns8	1411	33	a	a	DT
cord-023168-cd7adns8	1411	34	transfusion	transfusion	NN
cord-023168-cd7adns8	1411	35	.	.	.
cord-023168-cd7adns8	1412	1	This	this	DT
cord-023168-cd7adns8	1412	2	process	process	NN
cord-023168-cd7adns8	1412	3	,	,	,
cord-023168-cd7adns8	1412	4	known	know	VBN
cord-023168-cd7adns8	1412	5	as	as	IN
cord-023168-cd7adns8	1412	6	preoperative	preoperative	JJ
cord-023168-cd7adns8	1412	7	autologous	autologous	JJ
cord-023168-cd7adns8	1412	8	donation	donation	NN
cord-023168-cd7adns8	1412	9	,	,	,
cord-023168-cd7adns8	1412	10	can	can	MD
cord-023168-cd7adns8	1412	11	reduce	reduce	VB
cord-023168-cd7adns8	1412	12	the	the	DT
cord-023168-cd7adns8	1412	13	need	need	NN
cord-023168-cd7adns8	1412	14	for	for	IN
cord-023168-cd7adns8	1412	15	allogeneic	allogeneic	NN
cord-023168-cd7adns8	1412	16	transfusions	transfusion	NNS
cord-023168-cd7adns8	1412	17	by	by	IN
cord-023168-cd7adns8	1412	18	46	46	CD
cord-023168-cd7adns8	1412	19	-	-	SYM
cord-023168-cd7adns8	1412	20	74	74	CD
cord-023168-cd7adns8	1412	21	%	%	NN
cord-023168-cd7adns8	1412	22	355	355	CD
cord-023168-cd7adns8	1412	23	but	but	CC
cord-023168-cd7adns8	1412	24	it	-PRON-	PRP
cord-023168-cd7adns8	1412	25	requires	require	VBZ
cord-023168-cd7adns8	1412	26	careful	careful	JJ
cord-023168-cd7adns8	1412	27	organization	organization	NN
cord-023168-cd7adns8	1412	28	:	:	:
cord-023168-cd7adns8	1412	29	the	the	DT
cord-023168-cd7adns8	1412	30	surgeon	surgeon	NN
cord-023168-cd7adns8	1412	31	needs	need	VBZ
cord-023168-cd7adns8	1412	32	to	to	TO
cord-023168-cd7adns8	1412	33	predict	predict	VB
cord-023168-cd7adns8	1412	34	how	how	WRB
cord-023168-cd7adns8	1412	35	much	much	JJ
cord-023168-cd7adns8	1412	36	blood	blood	NN
cord-023168-cd7adns8	1412	37	will	will	MD
cord-023168-cd7adns8	1412	38	be	be	VB
cord-023168-cd7adns8	1412	39	required	require	VBN
cord-023168-cd7adns8	1412	40	,	,	,
cord-023168-cd7adns8	1412	41	the	the	DT
cord-023168-cd7adns8	1412	42	patient	patient	NN
cord-023168-cd7adns8	1412	43	has	have	VBZ
cord-023168-cd7adns8	1412	44	to	to	TO
cord-023168-cd7adns8	1412	45	be	be	VB
cord-023168-cd7adns8	1412	46	fit	fit	JJ
cord-023168-cd7adns8	1412	47	enough	enough	RB
cord-023168-cd7adns8	1412	48	to	to	TO
cord-023168-cd7adns8	1412	49	withstand	withstand	VB
cord-023168-cd7adns8	1412	50	removal	removal	NN
cord-023168-cd7adns8	1412	51	of	of	IN
cord-023168-cd7adns8	1412	52	one	one	CD
cord-023168-cd7adns8	1412	53	or	or	CC
cord-023168-cd7adns8	1412	54	more	more	JJR
cord-023168-cd7adns8	1412	55	units	unit	NNS
cord-023168-cd7adns8	1412	56	of	of	IN
cord-023168-cd7adns8	1412	57	blood	blood	NN
cord-023168-cd7adns8	1412	58	over	over	IN
cord-023168-cd7adns8	1412	59	the	the	DT
cord-023168-cd7adns8	1412	60	weeks	week	NNS
cord-023168-cd7adns8	1412	61	preceding	precede	VBG
cord-023168-cd7adns8	1412	62	the	the	DT
cord-023168-cd7adns8	1412	63	surgery	surgery	NN
cord-023168-cd7adns8	1412	64	and	and	CC
cord-023168-cd7adns8	1412	65	the	the	DT
cord-023168-cd7adns8	1412	66	surgery	surgery	NN
cord-023168-cd7adns8	1412	67	must	must	MD
cord-023168-cd7adns8	1412	68	take	take	VB
cord-023168-cd7adns8	1412	69	place	place	NN
cord-023168-cd7adns8	1412	70	within	within	IN
cord-023168-cd7adns8	1412	71	the	the	DT
cord-023168-cd7adns8	1412	72	shelf	shelf	NN
cord-023168-cd7adns8	1412	73	-	-	HYPH
cord-023168-cd7adns8	1412	74	life	life	NN
cord-023168-cd7adns8	1412	75	of	of	IN
cord-023168-cd7adns8	1412	76	the	the	DT
cord-023168-cd7adns8	1412	77	blood	blood	NN
cord-023168-cd7adns8	1412	78	.	.	.
cord-023168-cd7adns8	1413	1	As	as	IN
cord-023168-cd7adns8	1413	2	the	the	DT
cord-023168-cd7adns8	1413	3	blood	blood	NN
cord-023168-cd7adns8	1413	4	has	have	VBZ
cord-023168-cd7adns8	1413	5	to	to	TO
cord-023168-cd7adns8	1413	6	be	be	VB
cord-023168-cd7adns8	1413	7	stored	store	VBN
cord-023168-cd7adns8	1413	8	in	in	IN
cord-023168-cd7adns8	1413	9	the	the	DT
cord-023168-cd7adns8	1413	10	blood	blood	NN
cord-023168-cd7adns8	1413	11	bank	bank	NN
cord-023168-cd7adns8	1413	12	there	there	EX
cord-023168-cd7adns8	1413	13	is	be	VBZ
cord-023168-cd7adns8	1413	14	still	still	RB
cord-023168-cd7adns8	1413	15	a	a	DT
cord-023168-cd7adns8	1413	16	risk	risk	NN
cord-023168-cd7adns8	1413	17	that	that	IN
cord-023168-cd7adns8	1413	18	the	the	DT
cord-023168-cd7adns8	1413	19	patient	patient	NN
cord-023168-cd7adns8	1413	20	may	may	MD
cord-023168-cd7adns8	1413	21	receive	receive	VB
cord-023168-cd7adns8	1413	22	blood	blood	NN
cord-023168-cd7adns8	1413	23	which	which	WDT
cord-023168-cd7adns8	1413	24	is	be	VBZ
cord-023168-cd7adns8	1413	25	not	not	RB
cord-023168-cd7adns8	1413	26	their	-PRON-	PRP$
cord-023168-cd7adns8	1413	27	own	own	JJ
cord-023168-cd7adns8	1413	28	BOX	BOX	NNP
cord-023168-cd7adns8	1413	29	65.23	65.23	CD
cord-023168-cd7adns8	1413	30	PRESCRIBING	PRESCRIBING	NNP
cord-023168-cd7adns8	1413	31	BLOOD	blood	NN
cord-023168-cd7adns8	1413	32	:	:	:
cord-023168-cd7adns8	1413	33	A	a	DT
cord-023168-cd7adns8	1413	34	CHECKLIST	checklist	NN
cord-023168-cd7adns8	1413	35	FOR	for	IN
cord-023168-cd7adns8	1413	36	CLINICIANS	clinician	NNS
cord-023168-cd7adns8	1413	37	Always	always	RB
cord-023168-cd7adns8	1413	38	ask	ask	VBP
cord-023168-cd7adns8	1413	39	yourself	-PRON-	PRP
cord-023168-cd7adns8	1413	40	the	the	DT
cord-023168-cd7adns8	1413	41	following	follow	VBG
cord-023168-cd7adns8	1413	42	questions	question	NNS
cord-023168-cd7adns8	1413	43	before	before	IN
cord-023168-cd7adns8	1413	44	prescribing	prescribe	VBG
cord-023168-cd7adns8	1413	45	blood	blood	NN
cord-023168-cd7adns8	1413	46	or	or	CC
cord-023168-cd7adns8	1413	47	blood	blood	NN
cord-023168-cd7adns8	1413	48	products	product	NNS
cord-023168-cd7adns8	1413	49	for	for	IN
cord-023168-cd7adns8	1413	50	a	a	DT
cord-023168-cd7adns8	1413	51	patient	patient	NN
cord-023168-cd7adns8	1413	52	:	:	:
cord-023168-cd7adns8	1414	1	1	1	LS
cord-023168-cd7adns8	1414	2	.	.	.
cord-023168-cd7adns8	1415	1	What	what	WDT
cord-023168-cd7adns8	1415	2	improvement	improvement	NN
cord-023168-cd7adns8	1415	3	in	in	IN
cord-023168-cd7adns8	1415	4	the	the	DT
cord-023168-cd7adns8	1415	5	patient	patient	NN
cord-023168-cd7adns8	1415	6	's	's	POS
cord-023168-cd7adns8	1415	7	clinical	clinical	JJ
cord-023168-cd7adns8	1415	8	condition	condition	NN
cord-023168-cd7adns8	1415	9	am	be	VBP
cord-023168-cd7adns8	1415	10	I	-PRON-	PRP
cord-023168-cd7adns8	1415	11	aiming	aim	VBG
cord-023168-cd7adns8	1415	12	to	to	TO
cord-023168-cd7adns8	1415	13	achieve	achieve	VB
cord-023168-cd7adns8	1415	14	?	?	.
cord-023168-cd7adns8	1416	1	2	2	LS
cord-023168-cd7adns8	1416	2	.	.	.
cord-023168-cd7adns8	1417	1	Can	Can	MD
cord-023168-cd7adns8	1417	2	I	-PRON-	PRP
cord-023168-cd7adns8	1417	3	minimize	minimize	VB
cord-023168-cd7adns8	1417	4	blood	blood	NN
cord-023168-cd7adns8	1417	5	loss	loss	NN
cord-023168-cd7adns8	1417	6	to	to	TO
cord-023168-cd7adns8	1417	7	reduce	reduce	VB
cord-023168-cd7adns8	1417	8	this	this	DT
cord-023168-cd7adns8	1417	9	patient	patient	NN
cord-023168-cd7adns8	1417	10	's	's	POS
cord-023168-cd7adns8	1417	11	need	need	NN
cord-023168-cd7adns8	1417	12	for	for	IN
cord-023168-cd7adns8	1417	13	transfusion	transfusion	NN
cord-023168-cd7adns8	1417	14	?	?	.
cord-023168-cd7adns8	1418	1	3	3	LS
cord-023168-cd7adns8	1418	2	.	.	.
cord-023168-cd7adns8	1419	1	Are	be	VBP
cord-023168-cd7adns8	1419	2	there	there	EX
cord-023168-cd7adns8	1419	3	any	any	DT
cord-023168-cd7adns8	1419	4	other	other	JJ
cord-023168-cd7adns8	1419	5	treatments	treatment	NNS
cord-023168-cd7adns8	1419	6	I	-PRON-	PRP
cord-023168-cd7adns8	1419	7	should	should	MD
cord-023168-cd7adns8	1419	8	give	give	VB
cord-023168-cd7adns8	1419	9	before	before	IN
cord-023168-cd7adns8	1419	10	making	make	VBG
cord-023168-cd7adns8	1419	11	the	the	DT
cord-023168-cd7adns8	1419	12	decision	decision	NN
cord-023168-cd7adns8	1419	13	to	to	TO
cord-023168-cd7adns8	1419	14	transfuse	transfuse	VB
cord-023168-cd7adns8	1419	15	,	,	,
cord-023168-cd7adns8	1419	16	such	such	JJ
cord-023168-cd7adns8	1419	17	as	as	IN
cord-023168-cd7adns8	1419	18	intravenous	intravenous	JJ
cord-023168-cd7adns8	1419	19	replacement	replacement	NN
cord-023168-cd7adns8	1419	20	fluids	fluid	NNS
cord-023168-cd7adns8	1419	21	or	or	CC
cord-023168-cd7adns8	1419	22	oxygen	oxygen	NN
cord-023168-cd7adns8	1419	23	?	?	.
cord-023168-cd7adns8	1420	1	4	4	LS
cord-023168-cd7adns8	1420	2	.	.	.
cord-023168-cd7adns8	1421	1	What	what	WP
cord-023168-cd7adns8	1421	2	are	be	VBP
cord-023168-cd7adns8	1421	3	the	the	DT
cord-023168-cd7adns8	1421	4	specific	specific	JJ
cord-023168-cd7adns8	1421	5	clinical	clinical	JJ
cord-023168-cd7adns8	1421	6	or	or	CC
cord-023168-cd7adns8	1421	7	laboratory	laboratory	NN
cord-023168-cd7adns8	1421	8	indications	indication	NNS
cord-023168-cd7adns8	1421	9	for	for	IN
cord-023168-cd7adns8	1421	10	transfusion	transfusion	NN
cord-023168-cd7adns8	1421	11	in	in	IN
cord-023168-cd7adns8	1421	12	this	this	DT
cord-023168-cd7adns8	1421	13	patient	patient	NN
cord-023168-cd7adns8	1421	14	?	?	.
cord-023168-cd7adns8	1422	1	5	5	LS
cord-023168-cd7adns8	1422	2	.	.	.
cord-023168-cd7adns8	1423	1	What	what	WP
cord-023168-cd7adns8	1423	2	are	be	VBP
cord-023168-cd7adns8	1423	3	the	the	DT
cord-023168-cd7adns8	1423	4	risks	risk	NNS
cord-023168-cd7adns8	1423	5	of	of	IN
cord-023168-cd7adns8	1423	6	transmitting	transmit	VBG
cord-023168-cd7adns8	1423	7	HIV	HIV	NNP
cord-023168-cd7adns8	1423	8	,	,	,
cord-023168-cd7adns8	1423	9	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1423	10	,	,	,
cord-023168-cd7adns8	1423	11	syphilis	syphili	NNS
cord-023168-cd7adns8	1423	12	or	or	CC
cord-023168-cd7adns8	1423	13	other	other	JJ
cord-023168-cd7adns8	1423	14	infectious	infectious	JJ
cord-023168-cd7adns8	1423	15	agents	agent	NNS
cord-023168-cd7adns8	1423	16	through	through	IN
cord-023168-cd7adns8	1423	17	the	the	DT
cord-023168-cd7adns8	1423	18	blood	blood	NN
cord-023168-cd7adns8	1423	19	products	product	NNS
cord-023168-cd7adns8	1423	20	that	that	WDT
cord-023168-cd7adns8	1423	21	are	be	VBP
cord-023168-cd7adns8	1423	22	available	available	JJ
cord-023168-cd7adns8	1423	23	for	for	IN
cord-023168-cd7adns8	1423	24	this	this	DT
cord-023168-cd7adns8	1423	25	patient	patient	NN
cord-023168-cd7adns8	1423	26	?	?	.
cord-023168-cd7adns8	1424	1	bacterial	bacterial	JJ
cord-023168-cd7adns8	1424	2	contamination	contamination	NN
cord-023168-cd7adns8	1424	3	and	and	CC
cord-023168-cd7adns8	1424	4	should	should	MD
cord-023168-cd7adns8	1424	5	be	be	VB
cord-023168-cd7adns8	1424	6	investigated	investigate	VBN
cord-023168-cd7adns8	1424	7	and	and	CC
cord-023168-cd7adns8	1424	8	managed	manage	VBN
cord-023168-cd7adns8	1424	9	accordingly	accordingly	RB
cord-023168-cd7adns8	1424	10	.	.	.
cord-023168-cd7adns8	1425	1	Allergic	allergic	JJ
cord-023168-cd7adns8	1425	2	reactions	reaction	NNS
cord-023168-cd7adns8	1425	3	are	be	VBP
cord-023168-cd7adns8	1425	4	due	due	JJ
cord-023168-cd7adns8	1425	5	to	to	IN
cord-023168-cd7adns8	1425	6	infusion	infusion	NN
cord-023168-cd7adns8	1425	7	of	of	IN
cord-023168-cd7adns8	1425	8	plasma	plasma	NN
cord-023168-cd7adns8	1425	9	proteins	protein	NNS
cord-023168-cd7adns8	1425	10	and	and	CC
cord-023168-cd7adns8	1425	11	manifestations	manifestation	NNS
cord-023168-cd7adns8	1425	12	include	include	VBP
cord-023168-cd7adns8	1425	13	erythema	erythema	NN
cord-023168-cd7adns8	1425	14	,	,	,
cord-023168-cd7adns8	1425	15	rash	rash	JJ
cord-023168-cd7adns8	1425	16	,	,	,
cord-023168-cd7adns8	1425	17	pruritus	pruritus	NN
cord-023168-cd7adns8	1425	18	,	,	,
cord-023168-cd7adns8	1425	19	bronchospasm	bronchospasm	NN
cord-023168-cd7adns8	1425	20	and	and	CC
cord-023168-cd7adns8	1425	21	anaphylaxis	anaphylaxis	NN
cord-023168-cd7adns8	1425	22	.	.	.
cord-023168-cd7adns8	1426	1	The	the	DT
cord-023168-cd7adns8	1426	2	transfusion	transfusion	NN
cord-023168-cd7adns8	1426	3	should	should	MD
cord-023168-cd7adns8	1426	4	be	be	VB
cord-023168-cd7adns8	1426	5	stopped	stop	VBN
cord-023168-cd7adns8	1426	6	and	and	CC
cord-023168-cd7adns8	1426	7	the	the	DT
cord-023168-cd7adns8	1426	8	patient	patient	NN
cord-023168-cd7adns8	1426	9	treated	treat	VBN
cord-023168-cd7adns8	1426	10	with	with	IN
cord-023168-cd7adns8	1426	11	antihistamines	antihistamine	NNS
cord-023168-cd7adns8	1426	12	.	.	.
cord-023168-cd7adns8	1427	1	If	if	IN
cord-023168-cd7adns8	1427	2	the	the	DT
cord-023168-cd7adns8	1427	3	reaction	reaction	NN
cord-023168-cd7adns8	1427	4	is	be	VBZ
cord-023168-cd7adns8	1427	5	mild	mild	JJ
cord-023168-cd7adns8	1427	6	and	and	CC
cord-023168-cd7adns8	1427	7	the	the	DT
cord-023168-cd7adns8	1427	8	symptoms	symptom	NNS
cord-023168-cd7adns8	1427	9	and	and	CC
cord-023168-cd7adns8	1427	10	signs	sign	NNS
cord-023168-cd7adns8	1427	11	completely	completely	RB
cord-023168-cd7adns8	1427	12	disappear	disappear	VBP
cord-023168-cd7adns8	1427	13	,	,	,
cord-023168-cd7adns8	1427	14	the	the	DT
cord-023168-cd7adns8	1427	15	transfusion	transfusion	NN
cord-023168-cd7adns8	1427	16	can	can	MD
cord-023168-cd7adns8	1427	17	be	be	VB
cord-023168-cd7adns8	1427	18	restarted	restart	VBN
cord-023168-cd7adns8	1427	19	.	.	.
cord-023168-cd7adns8	1428	1	If	if	IN
cord-023168-cd7adns8	1428	2	this	this	DT
cord-023168-cd7adns8	1428	3	type	type	NN
cord-023168-cd7adns8	1428	4	of	of	IN
cord-023168-cd7adns8	1428	5	mild	mild	JJ
cord-023168-cd7adns8	1428	6	reaction	reaction	NN
cord-023168-cd7adns8	1428	7	occurs	occur	VBZ
cord-023168-cd7adns8	1428	8	repeatedly	repeatedly	RB
cord-023168-cd7adns8	1428	9	with	with	IN
cord-023168-cd7adns8	1428	10	more	more	JJR
cord-023168-cd7adns8	1428	11	than	than	IN
cord-023168-cd7adns8	1428	12	one	one	CD
cord-023168-cd7adns8	1428	13	unit	unit	NN
cord-023168-cd7adns8	1428	14	of	of	IN
cord-023168-cd7adns8	1428	15	blood	blood	NN
cord-023168-cd7adns8	1428	16	,	,	,
cord-023168-cd7adns8	1428	17	the	the	DT
cord-023168-cd7adns8	1428	18	red	red	JJ
cord-023168-cd7adns8	1428	19	cells	cell	NNS
cord-023168-cd7adns8	1428	20	can	can	MD
cord-023168-cd7adns8	1428	21	be	be	VB
cord-023168-cd7adns8	1428	22	washed	wash	VBN
cord-023168-cd7adns8	1428	23	before	before	IN
cord-023168-cd7adns8	1428	24	transfusion	transfusion	NN
cord-023168-cd7adns8	1428	25	.	.	.
cord-023168-cd7adns8	1429	1	This	this	DT
cord-023168-cd7adns8	1429	2	should	should	MD
cord-023168-cd7adns8	1429	3	only	only	RB
cord-023168-cd7adns8	1429	4	be	be	VB
cord-023168-cd7adns8	1429	5	done	do	VBN
cord-023168-cd7adns8	1429	6	if	if	IN
cord-023168-cd7adns8	1429	7	absolutely	absolutely	RB
cord-023168-cd7adns8	1429	8	necessary	necessary	JJ
cord-023168-cd7adns8	1429	9	,	,	,
cord-023168-cd7adns8	1429	10	as	as	IN
cord-023168-cd7adns8	1429	11	it	-PRON-	PRP
cord-023168-cd7adns8	1429	12	carries	carry	VBZ
cord-023168-cd7adns8	1429	13	the	the	DT
cord-023168-cd7adns8	1429	14	risk	risk	NN
cord-023168-cd7adns8	1429	15	of	of	IN
cord-023168-cd7adns8	1429	16	introducing	introduce	VBG
cord-023168-cd7adns8	1429	17	potentially	potentially	RB
cord-023168-cd7adns8	1429	18	fatal	fatal	JJ
cord-023168-cd7adns8	1429	19	bacterial	bacterial	JJ
cord-023168-cd7adns8	1429	20	infection	infection	NN
cord-023168-cd7adns8	1429	21	.	.	.
cord-023168-cd7adns8	1430	1	Severe	severe	JJ
cord-023168-cd7adns8	1430	2	allergic	allergic	JJ
cord-023168-cd7adns8	1430	3	reactions	reaction	NNS
cord-023168-cd7adns8	1430	4	with	with	IN
cord-023168-cd7adns8	1430	5	evidence	evidence	NN
cord-023168-cd7adns8	1430	6	of	of	IN
cord-023168-cd7adns8	1430	7	systemic	systemic	JJ
cord-023168-cd7adns8	1430	8	toxicity	toxicity	NN
cord-023168-cd7adns8	1430	9	should	should	MD
cord-023168-cd7adns8	1430	10	be	be	VB
cord-023168-cd7adns8	1430	11	managed	manage	VBN
cord-023168-cd7adns8	1430	12	as	as	IN
cord-023168-cd7adns8	1430	13	acute	acute	JJ
cord-023168-cd7adns8	1430	14	anaphylaxis	anaphylaxis	NN
cord-023168-cd7adns8	1430	15	.	.	.
cord-023168-cd7adns8	1431	1	Blood	blood	NN
cord-023168-cd7adns8	1431	2	should	should	MD
cord-023168-cd7adns8	1431	3	always	always	RB
cord-023168-cd7adns8	1431	4	be	be	VB
cord-023168-cd7adns8	1431	5	transfused	transfuse	VBN
cord-023168-cd7adns8	1431	6	slowly	slowly	RB
cord-023168-cd7adns8	1431	7	to	to	TO
cord-023168-cd7adns8	1431	8	avoid	avoid	VB
cord-023168-cd7adns8	1431	9	overloading	overload	VBG
cord-023168-cd7adns8	1431	10	the	the	DT
cord-023168-cd7adns8	1431	11	circulation	circulation	NN
cord-023168-cd7adns8	1431	12	,	,	,
cord-023168-cd7adns8	1431	13	unless	unless	IN
cord-023168-cd7adns8	1431	14	the	the	DT
cord-023168-cd7adns8	1431	15	patient	patient	NN
cord-023168-cd7adns8	1431	16	has	have	VBZ
cord-023168-cd7adns8	1431	17	active	active	JJ
cord-023168-cd7adns8	1431	18	and	and	CC
cord-023168-cd7adns8	1431	19	severe	severe	JJ
cord-023168-cd7adns8	1431	20	bleeding	bleeding	NN
cord-023168-cd7adns8	1431	21	.	.	.
cord-023168-cd7adns8	1432	1	Fluid	fluid	JJ
cord-023168-cd7adns8	1432	2	overload	overload	NN
cord-023168-cd7adns8	1432	3	may	may	MD
cord-023168-cd7adns8	1432	4	be	be	VB
cord-023168-cd7adns8	1432	5	a	a	DT
cord-023168-cd7adns8	1432	6	particular	particular	JJ
cord-023168-cd7adns8	1432	7	problem	problem	NN
cord-023168-cd7adns8	1432	8	when	when	WRB
cord-023168-cd7adns8	1432	9	paediatric	paediatric	JJ
cord-023168-cd7adns8	1432	10	blood	blood	NN
cord-023168-cd7adns8	1432	11	bags	bag	NNS
cord-023168-cd7adns8	1432	12	are	be	VBP
cord-023168-cd7adns8	1432	13	not	not	RB
cord-023168-cd7adns8	1432	14	available	available	JJ
cord-023168-cd7adns8	1432	15	,	,	,
cord-023168-cd7adns8	1432	16	as	as	IN
cord-023168-cd7adns8	1432	17	children	child	NNS
cord-023168-cd7adns8	1432	18	may	may	MD
cord-023168-cd7adns8	1432	19	be	be	VB
cord-023168-cd7adns8	1432	20	over	over	RB
cord-023168-cd7adns8	1432	21	-	-	HYPH
cord-023168-cd7adns8	1432	22	transfused	transfuse	VBN
cord-023168-cd7adns8	1432	23	due	due	IN
cord-023168-cd7adns8	1432	24	to	to	IN
cord-023168-cd7adns8	1432	25	miscalculation	miscalculation	NN
cord-023168-cd7adns8	1432	26	of	of	IN
cord-023168-cd7adns8	1432	27	the	the	DT
cord-023168-cd7adns8	1432	28	required	require	VBN
cord-023168-cd7adns8	1432	29	volume	volume	NN
cord-023168-cd7adns8	1432	30	,	,	,
cord-023168-cd7adns8	1432	31	lack	lack	NN
cord-023168-cd7adns8	1432	32	of	of	IN
cord-023168-cd7adns8	1432	33	accurate	accurate	JJ
cord-023168-cd7adns8	1432	34	infusion	infusion	NN
cord-023168-cd7adns8	1432	35	devices	device	NNS
cord-023168-cd7adns8	1432	36	or	or	CC
cord-023168-cd7adns8	1432	37	inadvertent	inadvertent	JJ
cord-023168-cd7adns8	1432	38	administration	administration	NN
cord-023168-cd7adns8	1432	39	of	of	IN
cord-023168-cd7adns8	1432	40	an	an	DT
cord-023168-cd7adns8	1432	41	adult	adult	NN
cord-023168-cd7adns8	1432	42	-	-	HYPH
cord-023168-cd7adns8	1432	43	sized	sized	JJ
cord-023168-cd7adns8	1432	44	unit	unit	NN
cord-023168-cd7adns8	1432	45	of	of	IN
cord-023168-cd7adns8	1432	46	blood	blood	NN
cord-023168-cd7adns8	1432	47	.	.	.
cord-023168-cd7adns8	1433	1	Four	four	CD
cord-023168-cd7adns8	1433	2	units	unit	NNS
cord-023168-cd7adns8	1433	3	of	of	IN
cord-023168-cd7adns8	1433	4	blood	blood	NN
cord-023168-cd7adns8	1433	5	contain	contain	VBP
cord-023168-cd7adns8	1433	6	the	the	DT
cord-023168-cd7adns8	1433	7	equivalent	equivalent	JJ
cord-023168-cd7adns8	1433	8	amount	amount	NN
cord-023168-cd7adns8	1433	9	of	of	IN
cord-023168-cd7adns8	1433	10	iron	iron	NN
cord-023168-cd7adns8	1433	11	stored	store	VBN
cord-023168-cd7adns8	1433	12	in	in	IN
cord-023168-cd7adns8	1433	13	bone	bone	NN
cord-023168-cd7adns8	1433	14	marrow	marrow	NN
cord-023168-cd7adns8	1433	15	(	(	-LRB-
cord-023168-cd7adns8	1433	16	approx	approx	NN
cord-023168-cd7adns8	1433	17	.	.	.
cord-023168-cd7adns8	1433	18	1	1	CD
cord-023168-cd7adns8	1433	19	g	g	NN
cord-023168-cd7adns8	1433	20	)	)	-RRB-
cord-023168-cd7adns8	1433	21	.	.	.
cord-023168-cd7adns8	1434	1	Repeated	repeat	VBN
cord-023168-cd7adns8	1434	2	transfusions	transfusion	NNS
cord-023168-cd7adns8	1434	3	for	for	IN
cord-023168-cd7adns8	1434	4	chronic	chronic	JJ
cord-023168-cd7adns8	1434	5	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1434	6	anaemia	anaemia	NN
cord-023168-cd7adns8	1434	7	,	,	,
cord-023168-cd7adns8	1434	8	as	as	IN
cord-023168-cd7adns8	1434	9	in	in	IN
cord-023168-cd7adns8	1434	10	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1434	11	major	major	JJ
cord-023168-cd7adns8	1434	12	and	and	CC
cord-023168-cd7adns8	1434	13	sickle	sickle	NN
cord-023168-cd7adns8	1434	14	cell	cell	NN
cord-023168-cd7adns8	1434	15	disease	disease	NN
cord-023168-cd7adns8	1434	16	,	,	,
cord-023168-cd7adns8	1434	17	lead	lead	VB
cord-023168-cd7adns8	1434	18	to	to	IN
cord-023168-cd7adns8	1434	19	iron	iron	NN
cord-023168-cd7adns8	1434	20	deposition	deposition	NN
cord-023168-cd7adns8	1434	21	in	in	IN
cord-023168-cd7adns8	1434	22	parenchymal	parenchymal	NN
cord-023168-cd7adns8	1434	23	cells	cell	NNS
cord-023168-cd7adns8	1434	24	.	.	.
cord-023168-cd7adns8	1435	1	Eventually	eventually	RB
cord-023168-cd7adns8	1435	2	failure	failure	NN
cord-023168-cd7adns8	1435	3	of	of	IN
cord-023168-cd7adns8	1435	4	the	the	DT
cord-023168-cd7adns8	1435	5	heart	heart	NN
cord-023168-cd7adns8	1435	6	,	,	,
cord-023168-cd7adns8	1435	7	liver	liver	NN
cord-023168-cd7adns8	1435	8	and	and	CC
cord-023168-cd7adns8	1435	9	other	other	JJ
cord-023168-cd7adns8	1435	10	organs	organ	NNS
cord-023168-cd7adns8	1435	11	supersedes	supersede	VBZ
cord-023168-cd7adns8	1435	12	.	.	.
cord-023168-cd7adns8	1436	1	Adequate	adequate	JJ
cord-023168-cd7adns8	1436	2	doses	dose	NNS
cord-023168-cd7adns8	1436	3	of	of	IN
cord-023168-cd7adns8	1436	4	iron	iron	NN
cord-023168-cd7adns8	1436	5	chelators	chelator	NNS
cord-023168-cd7adns8	1436	6	,	,	,
cord-023168-cd7adns8	1436	7	such	such	JJ
cord-023168-cd7adns8	1436	8	as	as	IN
cord-023168-cd7adns8	1436	9	injectable	injectable	JJ
cord-023168-cd7adns8	1436	10	desferrioxamine	desferrioxamine	NN
cord-023168-cd7adns8	1436	11	or	or	CC
cord-023168-cd7adns8	1436	12	oral	oral	JJ
cord-023168-cd7adns8	1436	13	deferiprone	deferiprone	NN
cord-023168-cd7adns8	1436	14	,	,	,
cord-023168-cd7adns8	1436	15	are	be	VBP
cord-023168-cd7adns8	1436	16	able	able	JJ
cord-023168-cd7adns8	1436	17	to	to	TO
cord-023168-cd7adns8	1436	18	maintain	maintain	VB
cord-023168-cd7adns8	1436	19	acceptable	acceptable	JJ
cord-023168-cd7adns8	1436	20	iron	iron	NN
cord-023168-cd7adns8	1436	21	balance	balance	NN
cord-023168-cd7adns8	1436	22	in	in	IN
cord-023168-cd7adns8	1436	23	patients	patient	NNS
cord-023168-cd7adns8	1436	24	with	with	IN
cord-023168-cd7adns8	1436	25	chronic	chronic	JJ
cord-023168-cd7adns8	1436	26	anaemia	anaemia	NN
cord-023168-cd7adns8	1436	27	who	who	WP
cord-023168-cd7adns8	1436	28	need	need	VBP
cord-023168-cd7adns8	1436	29	regular	regular	JJ
cord-023168-cd7adns8	1436	30	transfusions	transfusion	NNS
cord-023168-cd7adns8	1436	31	.	.	.
cord-023168-cd7adns8	1437	1	It	-PRON-	PRP
cord-023168-cd7adns8	1437	2	is	be	VBZ
cord-023168-cd7adns8	1437	3	not	not	RB
cord-023168-cd7adns8	1437	4	usually	usually	RB
cord-023168-cd7adns8	1437	5	necessary	necessary	JJ
cord-023168-cd7adns8	1437	6	to	to	TO
cord-023168-cd7adns8	1437	7	warm	warm	VB
cord-023168-cd7adns8	1437	8	blood	blood	NN
cord-023168-cd7adns8	1437	9	unless	unless	IN
cord-023168-cd7adns8	1437	10	large	large	JJ
cord-023168-cd7adns8	1437	11	quantities	quantity	NNS
cord-023168-cd7adns8	1437	12	are	be	VBP
cord-023168-cd7adns8	1437	13	transfused	transfuse	VBN
cord-023168-cd7adns8	1437	14	rapidly	rapidly	RB
cord-023168-cd7adns8	1437	15	.	.	.
cord-023168-cd7adns8	1438	1	This	this	DT
cord-023168-cd7adns8	1438	2	may	may	MD
cord-023168-cd7adns8	1438	3	lower	lower	VB
cord-023168-cd7adns8	1438	4	the	the	DT
cord-023168-cd7adns8	1438	5	temperature	temperature	NN
cord-023168-cd7adns8	1438	6	of	of	IN
cord-023168-cd7adns8	1438	7	the	the	DT
cord-023168-cd7adns8	1438	8	sino	sino	JJ
cord-023168-cd7adns8	1438	9	-	-	HYPH
cord-023168-cd7adns8	1438	10	atrial	atrial	JJ
cord-023168-cd7adns8	1438	11	node	node	NN
cord-023168-cd7adns8	1438	12	to	to	IN
cord-023168-cd7adns8	1438	13	below	below	IN
cord-023168-cd7adns8	1438	14	30	30	CD
cord-023168-cd7adns8	1438	15	°	°	NN
cord-023168-cd7adns8	1438	16	C	c	NN
cord-023168-cd7adns8	1438	17	at	at	IN
cord-023168-cd7adns8	1438	18	which	which	WDT
cord-023168-cd7adns8	1438	19	point	point	VBP
cord-023168-cd7adns8	1438	20	ventricular	ventricular	JJ
cord-023168-cd7adns8	1438	21	fibrillation	fibrillation	NN
cord-023168-cd7adns8	1438	22	can	can	MD
cord-023168-cd7adns8	1438	23	occur	occur	VB
cord-023168-cd7adns8	1438	24	.	.	.
cord-023168-cd7adns8	1439	1	If	if	IN
cord-023168-cd7adns8	1439	2	blood	blood	NN
cord-023168-cd7adns8	1439	3	needs	need	VBZ
cord-023168-cd7adns8	1439	4	to	to	TO
cord-023168-cd7adns8	1439	5	be	be	VB
cord-023168-cd7adns8	1439	6	warmed	warm	VBN
cord-023168-cd7adns8	1439	7	,	,	,
cord-023168-cd7adns8	1439	8	an	an	DT
cord-023168-cd7adns8	1439	9	electric	electric	JJ
cord-023168-cd7adns8	1439	10	blood	blood	NN
cord-023168-cd7adns8	1439	11	warmer	warm	JJR
cord-023168-cd7adns8	1439	12	specifically	specifically	RB
cord-023168-cd7adns8	1439	13	designed	design	VBN
cord-023168-cd7adns8	1439	14	for	for	IN
cord-023168-cd7adns8	1439	15	the	the	DT
cord-023168-cd7adns8	1439	16	purpose	purpose	NN
cord-023168-cd7adns8	1439	17	should	should	MD
cord-023168-cd7adns8	1439	18	be	be	VB
cord-023168-cd7adns8	1439	19	used	use	VBN
cord-023168-cd7adns8	1439	20	.	.	.
cord-023168-cd7adns8	1440	1	This	this	DT
cord-023168-cd7adns8	1440	2	keeps	keep	VBZ
cord-023168-cd7adns8	1440	3	the	the	DT
cord-023168-cd7adns8	1440	4	temperature	temperature	NN
cord-023168-cd7adns8	1440	5	below	below	IN
cord-023168-cd7adns8	1440	6	38	38	CD
cord-023168-cd7adns8	1440	7	°	°	NN
cord-023168-cd7adns8	1440	8	C	c	NN
cord-023168-cd7adns8	1440	9	and	and	CC
cord-023168-cd7adns8	1440	10	avoids	avoid	VBZ
cord-023168-cd7adns8	1440	11	the	the	DT
cord-023168-cd7adns8	1440	12	haemolysis	haemolysis	NN
cord-023168-cd7adns8	1440	13	associated	associate	VBN
cord-023168-cd7adns8	1440	14	with	with	IN
cord-023168-cd7adns8	1440	15	overheating	overheat	VBG
cord-023168-cd7adns8	1440	16	blood	blood	NN
cord-023168-cd7adns8	1440	17	.	.	.
cord-023168-cd7adns8	1441	1	Graft	graft	NN
cord-023168-cd7adns8	1441	2	-	-	HYPH
cord-023168-cd7adns8	1441	3	versus	versus	IN
cord-023168-cd7adns8	1441	4	-	-	HYPH
cord-023168-cd7adns8	1441	5	host	host	NN
cord-023168-cd7adns8	1441	6	disease	disease	NN
cord-023168-cd7adns8	1441	7	occurs	occur	VBZ
cord-023168-cd7adns8	1441	8	when	when	WRB
cord-023168-cd7adns8	1441	9	donor	donor	NN
cord-023168-cd7adns8	1441	10	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	1441	11	engraft	engraft	VBP
cord-023168-cd7adns8	1441	12	in	in	IN
cord-023168-cd7adns8	1441	13	an	an	DT
cord-023168-cd7adns8	1441	14	immune	immune	NN
cord-023168-cd7adns8	1441	15	-	-	HYPH
cord-023168-cd7adns8	1441	16	suppressed	suppress	VBN
cord-023168-cd7adns8	1441	17	recipient	recipient	NN
cord-023168-cd7adns8	1441	18	.	.	.
cord-023168-cd7adns8	1442	1	The	the	DT
cord-023168-cd7adns8	1442	2	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	1442	3	recognize	recognize	VBP
cord-023168-cd7adns8	1442	4	the	the	DT
cord-023168-cd7adns8	1442	5	recipient	recipient	NN
cord-023168-cd7adns8	1442	6	's	's	POS
cord-023168-cd7adns8	1442	7	bone	bone	NN
cord-023168-cd7adns8	1442	8	marrow	marrow	NN
cord-023168-cd7adns8	1442	9	as	as	IN
cord-023168-cd7adns8	1442	10	foreign	foreign	JJ
cord-023168-cd7adns8	1442	11	and	and	CC
cord-023168-cd7adns8	1442	12	induce	induce	VB
cord-023168-cd7adns8	1442	13	aplasia	aplasia	NNP
cord-023168-cd7adns8	1442	14	.	.	.
cord-023168-cd7adns8	1443	1	Graft	graft	NN
cord-023168-cd7adns8	1443	2	-	-	HYPH
cord-023168-cd7adns8	1443	3	versus	versus	IN
cord-023168-cd7adns8	1443	4	-	-	HYPH
cord-023168-cd7adns8	1443	5	host	host	NN
cord-023168-cd7adns8	1443	6	disease	disease	NN
cord-023168-cd7adns8	1443	7	is	be	VBZ
cord-023168-cd7adns8	1443	8	almost	almost	RB
cord-023168-cd7adns8	1443	9	universally	universally	RB
cord-023168-cd7adns8	1443	10	fatal	fatal	JJ
cord-023168-cd7adns8	1443	11	and	and	CC
cord-023168-cd7adns8	1443	12	can	can	MD
cord-023168-cd7adns8	1443	13	be	be	VB
cord-023168-cd7adns8	1443	14	prevented	prevent	VBN
cord-023168-cd7adns8	1443	15	by	by	IN
cord-023168-cd7adns8	1443	16	irradiating	irradiate	VBG
cord-023168-cd7adns8	1443	17	the	the	DT
cord-023168-cd7adns8	1443	18	donor	donor	NN
cord-023168-cd7adns8	1443	19	blood	blood	NN
cord-023168-cd7adns8	1443	20	,	,	,
cord-023168-cd7adns8	1443	21	which	which	WDT
cord-023168-cd7adns8	1443	22	inactivates	inactivate	VBZ
cord-023168-cd7adns8	1443	23	the	the	DT
cord-023168-cd7adns8	1443	24	donor	donor	NN
cord-023168-cd7adns8	1443	25	lymphocytes	lymphocyte	NNS
cord-023168-cd7adns8	1443	26	.	.	.
cord-023168-cd7adns8	1444	1	Transfusion	transfusion	NN
cord-023168-cd7adns8	1444	2	of	of	IN
cord-023168-cd7adns8	1444	3	blood	blood	NN
cord-023168-cd7adns8	1444	4	into	into	IN
cord-023168-cd7adns8	1444	5	a	a	DT
cord-023168-cd7adns8	1444	6	recipient	recipient	NN
cord-023168-cd7adns8	1444	7	who	who	WP
cord-023168-cd7adns8	1444	8	possesses	possess	VBZ
cord-023168-cd7adns8	1444	9	antibodies	antibody	NNS
cord-023168-cd7adns8	1444	10	to	to	IN
cord-023168-cd7adns8	1444	11	the	the	DT
cord-023168-cd7adns8	1444	12	donor	donor	NN
cord-023168-cd7adns8	1444	13	's	's	POS
cord-023168-cd7adns8	1444	14	red	red	JJ
cord-023168-cd7adns8	1444	15	cells	cell	NNS
cord-023168-cd7adns8	1444	16	can	can	MD
cord-023168-cd7adns8	1444	17	cause	cause	VB
cord-023168-cd7adns8	1444	18	an	an	DT
cord-023168-cd7adns8	1444	19	acute	acute	NN
cord-023168-cd7adns8	1444	20	,	,	,
cord-023168-cd7adns8	1444	21	and	and	CC
cord-023168-cd7adns8	1444	22	occasionally	occasionally	RB
cord-023168-cd7adns8	1444	23	fatal	fatal	JJ
cord-023168-cd7adns8	1444	24	,	,	,
cord-023168-cd7adns8	1444	25	intravascular	intravascular	JJ
cord-023168-cd7adns8	1444	26	haemolysis	haemolysis	NN
cord-023168-cd7adns8	1444	27	.	.	.
cord-023168-cd7adns8	1445	1	This	this	DT
cord-023168-cd7adns8	1445	2	could	could	MD
cord-023168-cd7adns8	1445	3	occur	occur	VB
cord-023168-cd7adns8	1445	4	,	,	,
cord-023168-cd7adns8	1445	5	e.g.	e.g.	RB
cord-023168-cd7adns8	1445	6	if	if	IN
cord-023168-cd7adns8	1445	7	group	group	NN
cord-023168-cd7adns8	1445	8	A	a	DT
cord-023168-cd7adns8	1445	9	cells	cell	NNS
cord-023168-cd7adns8	1445	10	are	be	VBP
cord-023168-cd7adns8	1445	11	transfused	transfuse	VBN
cord-023168-cd7adns8	1445	12	into	into	IN
cord-023168-cd7adns8	1445	13	a	a	DT
cord-023168-cd7adns8	1445	14	group	group	NN
cord-023168-cd7adns8	1445	15	O	o	NN
cord-023168-cd7adns8	1445	16	recipient	recipient	NN
cord-023168-cd7adns8	1445	17	who	who	WP
cord-023168-cd7adns8	1445	18	has	have	VBZ
cord-023168-cd7adns8	1445	19	naturally	naturally	RB
cord-023168-cd7adns8	1445	20	occurring	occur	VBG
cord-023168-cd7adns8	1445	21	antibodies	antibody	NNS
cord-023168-cd7adns8	1445	22	to	to	TO
cord-023168-cd7adns8	1445	23	group	group	VB
cord-023168-cd7adns8	1445	24	A	a	DT
cord-023168-cd7adns8	1445	25	cells	cell	NNS
cord-023168-cd7adns8	1445	26	.	.	.
cord-023168-cd7adns8	1446	1	The	the	DT
cord-023168-cd7adns8	1446	2	profound	profound	JJ
cord-023168-cd7adns8	1446	3	haemolysis	haemolysis	NN
cord-023168-cd7adns8	1446	4	induces	induce	VBZ
cord-023168-cd7adns8	1446	5	renal	renal	JJ
cord-023168-cd7adns8	1446	6	vasoconstriction	vasoconstriction	NN
cord-023168-cd7adns8	1446	7	and	and	CC
cord-023168-cd7adns8	1446	8	acute	acute	JJ
cord-023168-cd7adns8	1446	9	tubular	tubular	JJ
cord-023168-cd7adns8	1446	10	necrosis	necrosis	NN
cord-023168-cd7adns8	1446	11	.	.	.
cord-023168-cd7adns8	1447	1	Treatment	treatment	NN
cord-023168-cd7adns8	1447	2	involves	involve	VBZ
cord-023168-cd7adns8	1447	3	stopping	stop	VBG
cord-023168-cd7adns8	1447	4	the	the	DT
cord-023168-cd7adns8	1447	5	transfusion	transfusion	NN
cord-023168-cd7adns8	1447	6	,	,	,
cord-023168-cd7adns8	1447	7	cardiorespiratory	cardiorespiratory	JJ
cord-023168-cd7adns8	1447	8	support	support	NN
cord-023168-cd7adns8	1447	9	and	and	CC
cord-023168-cd7adns8	1447	10	inducing	induce	VBG
cord-023168-cd7adns8	1447	11	a	a	DT
cord-023168-cd7adns8	1447	12	brisk	brisk	JJ
cord-023168-cd7adns8	1447	13	diuresis	diuresis	NN
cord-023168-cd7adns8	1447	14	.	.	.
cord-023168-cd7adns8	1448	1	In	in	IN
cord-023168-cd7adns8	1448	2	addition	addition	NN
cord-023168-cd7adns8	1448	3	to	to	IN
cord-023168-cd7adns8	1448	4	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1448	5	indicating	indicate	VBG
cord-023168-cd7adns8	1448	6	renal	renal	JJ
cord-023168-cd7adns8	1448	7	failure	failure	NN
cord-023168-cd7adns8	1448	8	,	,	,
cord-023168-cd7adns8	1448	9	laboratory	laboratory	NN
cord-023168-cd7adns8	1448	10	findings	finding	NNS
cord-023168-cd7adns8	1448	11	include	include	VBP
cord-023168-cd7adns8	1448	12	haemoglobinuria	haemoglobinuria	NNP
cord-023168-cd7adns8	1448	13	and	and	CC
cord-023168-cd7adns8	1448	14	haemoglobinaemia	haemoglobinaemia	NNP
cord-023168-cd7adns8	1448	15	.	.	.
cord-023168-cd7adns8	1449	1	Proof	proof	NN
cord-023168-cd7adns8	1449	2	of	of	IN
cord-023168-cd7adns8	1449	3	the	the	DT
cord-023168-cd7adns8	1449	4	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1449	5	involves	involve	VBZ
cord-023168-cd7adns8	1449	6	rechecking	rechecke	VBG
cord-023168-cd7adns8	1449	7	the	the	DT
cord-023168-cd7adns8	1449	8	whole	whole	JJ
cord-023168-cd7adns8	1449	9	transfusion	transfusion	NN
cord-023168-cd7adns8	1449	10	process	process	NN
cord-023168-cd7adns8	1449	11	including	include	VBG
cord-023168-cd7adns8	1449	12	all	all	DT
cord-023168-cd7adns8	1449	13	documentation	documentation	NN
cord-023168-cd7adns8	1449	14	stages	stage	NNS
cord-023168-cd7adns8	1449	15	,	,	,
cord-023168-cd7adns8	1449	16	regrouping	regroup	VBG
cord-023168-cd7adns8	1449	17	the	the	DT
cord-023168-cd7adns8	1449	18	donor	donor	NN
cord-023168-cd7adns8	1449	19	and	and	CC
cord-023168-cd7adns8	1449	20	the	the	DT
cord-023168-cd7adns8	1449	21	recipient	recipient	NN
cord-023168-cd7adns8	1449	22	,	,	,
cord-023168-cd7adns8	1449	23	and	and	CC
cord-023168-cd7adns8	1449	24	screening	screen	VBG
cord-023168-cd7adns8	1449	25	for	for	IN
cord-023168-cd7adns8	1449	26	antibodies	antibody	NNS
cord-023168-cd7adns8	1449	27	on	on	IN
cord-023168-cd7adns8	1449	28	red	red	JJ
cord-023168-cd7adns8	1449	29	cells	cell	NNS
cord-023168-cd7adns8	1449	30	with	with	IN
cord-023168-cd7adns8	1449	31	a	a	DT
cord-023168-cd7adns8	1449	32	direct	direct	JJ
cord-023168-cd7adns8	1449	33	antiglobulin	antiglobulin	NN
cord-023168-cd7adns8	1449	34	test	test	NN
cord-023168-cd7adns8	1449	35	.	.	.
cord-023168-cd7adns8	1450	1	These	these	DT
cord-023168-cd7adns8	1450	2	tests	test	NNS
cord-023168-cd7adns8	1450	3	are	be	VBP
cord-023168-cd7adns8	1450	4	usually	usually	RB
cord-023168-cd7adns8	1450	5	available	available	JJ
cord-023168-cd7adns8	1450	6	in	in	IN
cord-023168-cd7adns8	1450	7	any	any	DT
cord-023168-cd7adns8	1450	8	hospital	hospital	NN
cord-023168-cd7adns8	1450	9	laboratory	laboratory	NN
cord-023168-cd7adns8	1450	10	capable	capable	JJ
cord-023168-cd7adns8	1450	11	of	of	IN
cord-023168-cd7adns8	1450	12	providing	provide	VBG
cord-023168-cd7adns8	1450	13	a	a	DT
cord-023168-cd7adns8	1450	14	transfusion	transfusion	NN
cord-023168-cd7adns8	1450	15	service	service	NN
cord-023168-cd7adns8	1450	16	.	.	.
cord-023168-cd7adns8	1451	1	Delayed	delayed	JJ
cord-023168-cd7adns8	1451	2	haemolysis	haemolysis	NN
cord-023168-cd7adns8	1451	3	has	have	VBZ
cord-023168-cd7adns8	1451	4	a	a	DT
cord-023168-cd7adns8	1451	5	similar	similar	JJ
cord-023168-cd7adns8	1451	6	physiological	physiological	JJ
cord-023168-cd7adns8	1451	7	basis	basis	NN
cord-023168-cd7adns8	1451	8	to	to	IN
cord-023168-cd7adns8	1451	9	acute	acute	JJ
cord-023168-cd7adns8	1451	10	intravascular	intravascular	JJ
cord-023168-cd7adns8	1451	11	haemolysis	haemolysis	NN
cord-023168-cd7adns8	1452	1	but	but	CC
cord-023168-cd7adns8	1452	2	it	-PRON-	PRP
cord-023168-cd7adns8	1452	3	tends	tend	VBZ
cord-023168-cd7adns8	1452	4	to	to	TO
cord-023168-cd7adns8	1452	5	be	be	VB
cord-023168-cd7adns8	1452	6	less	less	RBR
cord-023168-cd7adns8	1452	7	severe	severe	JJ
cord-023168-cd7adns8	1453	1	,	,	,
cord-023168-cd7adns8	1453	2	it	-PRON-	PRP
cord-023168-cd7adns8	1453	3	occurs	occur	VBZ
cord-023168-cd7adns8	1453	4	7	7	CD
cord-023168-cd7adns8	1453	5	-	-	SYM
cord-023168-cd7adns8	1453	6	10	10	CD
cord-023168-cd7adns8	1453	7	days	day	NNS
cord-023168-cd7adns8	1453	8	after	after	IN
cord-023168-cd7adns8	1453	9	the	the	DT
cord-023168-cd7adns8	1453	10	transfusion	transfusion	NN
cord-023168-cd7adns8	1453	11	and	and	CC
cord-023168-cd7adns8	1453	12	it	-PRON-	PRP
cord-023168-cd7adns8	1453	13	is	be	VBZ
cord-023168-cd7adns8	1453	14	less	less	RBR
cord-023168-cd7adns8	1453	15	likely	likely	JJ
cord-023168-cd7adns8	1453	16	to	to	TO
cord-023168-cd7adns8	1453	17	present	present	VB
cord-023168-cd7adns8	1453	18	as	as	IN
cord-023168-cd7adns8	1453	19	a	a	DT
cord-023168-cd7adns8	1453	20	clinical	clinical	JJ
cord-023168-cd7adns8	1453	21	emergency	emergency	NN
cord-023168-cd7adns8	1453	22	.	.	.
cord-023168-cd7adns8	1454	1	Limited	limited	JJ
cord-023168-cd7adns8	1454	2	data	datum	NNS
cord-023168-cd7adns8	1454	3	from	from	IN
cord-023168-cd7adns8	1454	4	sub	sub	JJ
cord-023168-cd7adns8	1454	5	-	-	JJ
cord-023168-cd7adns8	1454	6	Saharan	Saharan	NNP
cord-023168-cd7adns8	1454	7	Africa	Africa	NNP
cord-023168-cd7adns8	1454	8	show	show	VBP
cord-023168-cd7adns8	1454	9	rates	rate	NNS
cord-023168-cd7adns8	1454	10	of	of	IN
cord-023168-cd7adns8	1454	11	bacterial	bacterial	JJ
cord-023168-cd7adns8	1454	12	contamination	contamination	NN
cord-023168-cd7adns8	1454	13	in	in	IN
cord-023168-cd7adns8	1454	14	donated	donate	VBN
cord-023168-cd7adns8	1454	15	blood	blood	NN
cord-023168-cd7adns8	1454	16	of	of	IN
cord-023168-cd7adns8	1454	17	around	around	IN
cord-023168-cd7adns8	1454	18	9	9	CD
cord-023168-cd7adns8	1454	19	%	%	NN
cord-023168-cd7adns8	1454	20	361,362	361,362	CD
cord-023168-cd7adns8	1454	21	but	but	CC
cord-023168-cd7adns8	1454	22	the	the	DT
cord-023168-cd7adns8	1454	23	clinical	clinical	JJ
cord-023168-cd7adns8	1454	24	consequences	consequence	NNS
cord-023168-cd7adns8	1454	25	for	for	IN
cord-023168-cd7adns8	1454	26	transfusion	transfusion	NN
cord-023168-cd7adns8	1454	27	recipients	recipient	NNS
cord-023168-cd7adns8	1454	28	are	be	VBP
cord-023168-cd7adns8	1454	29	unknown	unknown	JJ
cord-023168-cd7adns8	1454	30	.	.	.
cord-023168-cd7adns8	1455	1	Bacteria	Bacteria	NNS
cord-023168-cd7adns8	1455	2	can	can	MD
cord-023168-cd7adns8	1455	3	enter	enter	VB
cord-023168-cd7adns8	1455	4	the	the	DT
cord-023168-cd7adns8	1455	5	blood	blood	NN
cord-023168-cd7adns8	1455	6	bag	bag	NN
cord-023168-cd7adns8	1455	7	during	during	IN
cord-023168-cd7adns8	1455	8	venesection	venesection	NN
cord-023168-cd7adns8	1455	9	or	or	CC
cord-023168-cd7adns8	1455	10	if	if	IN
cord-023168-cd7adns8	1455	11	the	the	DT
cord-023168-cd7adns8	1455	12	bag	bag	NN
cord-023168-cd7adns8	1455	13	is	be	VBZ
cord-023168-cd7adns8	1455	14	breached	breach	VBN
cord-023168-cd7adns8	1455	15	,	,	,
cord-023168-cd7adns8	1455	16	e.g.	e.g.	RB
cord-023168-cd7adns8	1455	17	when	when	WRB
cord-023168-cd7adns8	1455	18	reducing	reduce	VBG
cord-023168-cd7adns8	1455	19	the	the	DT
cord-023168-cd7adns8	1455	20	volume	volume	NN
cord-023168-cd7adns8	1455	21	for	for	IN
cord-023168-cd7adns8	1455	22	a	a	DT
cord-023168-cd7adns8	1455	23	paediatric	paediatric	JJ
cord-023168-cd7adns8	1455	24	recipient	recipient	NN
cord-023168-cd7adns8	1455	25	or	or	CC
cord-023168-cd7adns8	1455	26	during	during	IN
cord-023168-cd7adns8	1455	27	component	component	NN
cord-023168-cd7adns8	1455	28	preparation	preparation	NN
cord-023168-cd7adns8	1455	29	.	.	.
cord-023168-cd7adns8	1456	1	Gram	gram	NN
cord-023168-cd7adns8	1456	2	-	-	HYPH
cord-023168-cd7adns8	1456	3	negative	negative	JJ
cord-023168-cd7adns8	1456	4	bacteria	bacteria	NNS
cord-023168-cd7adns8	1456	5	,	,	,
cord-023168-cd7adns8	1456	6	including	include	VBG
cord-023168-cd7adns8	1456	7	Pseudomonas	Pseudomonas	NNP
cord-023168-cd7adns8	1456	8	and	and	CC
cord-023168-cd7adns8	1456	9	Yersinia	Yersinia	NNP
cord-023168-cd7adns8	1456	10	,	,	,
cord-023168-cd7adns8	1456	11	grow	grow	VB
cord-023168-cd7adns8	1456	12	optimally	optimally	RB
cord-023168-cd7adns8	1456	13	at	at	IN
cord-023168-cd7adns8	1456	14	4	4	CD
cord-023168-cd7adns8	1456	15	°	°	NN
cord-023168-cd7adns8	1456	16	C	c	NN
cord-023168-cd7adns8	1456	17	and	and	CC
cord-023168-cd7adns8	1456	18	infected	infected	JJ
cord-023168-cd7adns8	1456	19	blood	blood	NN
cord-023168-cd7adns8	1456	20	may	may	MD
cord-023168-cd7adns8	1456	21	not	not	RB
cord-023168-cd7adns8	1456	22	necessarily	necessarily	RB
cord-023168-cd7adns8	1456	23	appear	appear	VB
cord-023168-cd7adns8	1456	24	abnormal	abnormal	JJ
cord-023168-cd7adns8	1456	25	to	to	IN
cord-023168-cd7adns8	1456	26	the	the	DT
cord-023168-cd7adns8	1456	27	naked	naked	JJ
cord-023168-cd7adns8	1456	28	eye	eye	NN
cord-023168-cd7adns8	1456	29	.	.	.
cord-023168-cd7adns8	1457	1	Reactions	reaction	NNS
cord-023168-cd7adns8	1457	2	following	follow	VBG
cord-023168-cd7adns8	1457	3	infusion	infusion	NN
cord-023168-cd7adns8	1457	4	of	of	IN
cord-023168-cd7adns8	1457	5	infected	infected	JJ
cord-023168-cd7adns8	1457	6	blood	blood	NN
cord-023168-cd7adns8	1457	7	are	be	VBP
cord-023168-cd7adns8	1457	8	often	often	RB
cord-023168-cd7adns8	1457	9	due	due	JJ
cord-023168-cd7adns8	1457	10	to	to	IN
cord-023168-cd7adns8	1457	11	endotoxins	endotoxin	NNS
cord-023168-cd7adns8	1457	12	and	and	CC
cord-023168-cd7adns8	1457	13	may	may	MD
cord-023168-cd7adns8	1457	14	occur	occur	VB
cord-023168-cd7adns8	1457	15	several	several	JJ
cord-023168-cd7adns8	1457	16	hours	hour	NNS
cord-023168-cd7adns8	1457	17	after	after	IN
cord-023168-cd7adns8	1457	18	the	the	DT
cord-023168-cd7adns8	1457	19	transfusion	transfusion	NN
cord-023168-cd7adns8	1457	20	has	have	VBZ
cord-023168-cd7adns8	1457	21	finished	finish	VBN
cord-023168-cd7adns8	1457	22	.	.	.
cord-023168-cd7adns8	1458	1	Although	although	IN
cord-023168-cd7adns8	1458	2	these	these	DT
cord-023168-cd7adns8	1458	3	reactions	reaction	NNS
cord-023168-cd7adns8	1458	4	are	be	VBP
cord-023168-cd7adns8	1458	5	rare	rare	JJ
cord-023168-cd7adns8	1458	6	,	,	,
cord-023168-cd7adns8	1458	7	they	-PRON-	PRP
cord-023168-cd7adns8	1458	8	can	can	MD
cord-023168-cd7adns8	1458	9	be	be	VB
cord-023168-cd7adns8	1458	10	severe	severe	JJ
cord-023168-cd7adns8	1458	11	and	and	CC
cord-023168-cd7adns8	1458	12	fatal	fatal	JJ
cord-023168-cd7adns8	1458	13	.	.	.
cord-023168-cd7adns8	1459	1	If	if	IN
cord-023168-cd7adns8	1459	2	bacterial	bacterial	JJ
cord-023168-cd7adns8	1459	3	contamination	contamination	NN
cord-023168-cd7adns8	1459	4	is	be	VBZ
cord-023168-cd7adns8	1459	5	suspected	suspect	VBN
cord-023168-cd7adns8	1459	6	,	,	,
cord-023168-cd7adns8	1459	7	the	the	DT
cord-023168-cd7adns8	1459	8	transfusion	transfusion	NN
cord-023168-cd7adns8	1459	9	should	should	MD
cord-023168-cd7adns8	1459	10	be	be	VB
cord-023168-cd7adns8	1459	11	stopped	stop	VBN
cord-023168-cd7adns8	1459	12	and	and	CC
cord-023168-cd7adns8	1459	13	samples	sample	NNS
cord-023168-cd7adns8	1459	14	from	from	IN
cord-023168-cd7adns8	1459	15	the	the	DT
cord-023168-cd7adns8	1459	16	patient	patient	NN
cord-023168-cd7adns8	1459	17	and	and	CC
cord-023168-cd7adns8	1459	18	the	the	DT
cord-023168-cd7adns8	1459	19	blood	blood	NN
cord-023168-cd7adns8	1459	20	bag	bag	NN
cord-023168-cd7adns8	1459	21	sent	send	VBN
cord-023168-cd7adns8	1459	22	to	to	IN
cord-023168-cd7adns8	1459	23	the	the	DT
cord-023168-cd7adns8	1459	24	laboratory	laboratory	NN
cord-023168-cd7adns8	1459	25	for	for	IN
cord-023168-cd7adns8	1459	26	culture	culture	NN
cord-023168-cd7adns8	1459	27	.	.	.
cord-023168-cd7adns8	1460	1	Cardiorespiratory	Cardiorespiratory	NNP
cord-023168-cd7adns8	1460	2	support	support	NN
cord-023168-cd7adns8	1460	3	may	may	MD
cord-023168-cd7adns8	1460	4	be	be	VB
cord-023168-cd7adns8	1460	5	needed	need	VBN
cord-023168-cd7adns8	1460	6	and	and	CC
cord-023168-cd7adns8	1460	7	broad	broad	JJ
cord-023168-cd7adns8	1460	8	-	-	HYPH
cord-023168-cd7adns8	1460	9	spectrum	spectrum	NN
cord-023168-cd7adns8	1460	10	antibiotics	antibiotic	NNS
cord-023168-cd7adns8	1460	11	should	should	MD
cord-023168-cd7adns8	1460	12	be	be	VB
cord-023168-cd7adns8	1460	13	started	start	VBN
cord-023168-cd7adns8	1460	14	immediately	immediately	RB
cord-023168-cd7adns8	1460	15	and	and	CC
cord-023168-cd7adns8	1460	16	continued	continue	VBN
cord-023168-cd7adns8	1460	17	until	until	IN
cord-023168-cd7adns8	1460	18	culture	culture	NN
cord-023168-cd7adns8	1460	19	results	result	NNS
cord-023168-cd7adns8	1460	20	are	be	VBP
cord-023168-cd7adns8	1460	21	available	available	JJ
cord-023168-cd7adns8	1460	22	.	.	.
cord-023168-cd7adns8	1461	1	Non	non	JJ
cord-023168-cd7adns8	1461	2	-	-	JJ
cord-023168-cd7adns8	1461	3	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1461	4	febrile	febrile	JJ
cord-023168-cd7adns8	1461	5	reactions	reaction	NNS
cord-023168-cd7adns8	1461	6	are	be	VBP
cord-023168-cd7adns8	1461	7	episodes	episode	NNS
cord-023168-cd7adns8	1461	8	of	of	IN
cord-023168-cd7adns8	1461	9	fever	fever	NN
cord-023168-cd7adns8	1461	10	and	and	CC
cord-023168-cd7adns8	1461	11	chills	chill	NNS
cord-023168-cd7adns8	1461	12	associated	associate	VBN
cord-023168-cd7adns8	1461	13	with	with	IN
cord-023168-cd7adns8	1461	14	transfusion	transfusion	NN
cord-023168-cd7adns8	1461	15	and	and	CC
cord-023168-cd7adns8	1461	16	for	for	IN
cord-023168-cd7adns8	1461	17	which	which	WDT
cord-023168-cd7adns8	1461	18	no	no	DT
cord-023168-cd7adns8	1461	19	other	other	JJ
cord-023168-cd7adns8	1461	20	cause	cause	NN
cord-023168-cd7adns8	1461	21	can	can	MD
cord-023168-cd7adns8	1461	22	be	be	VB
cord-023168-cd7adns8	1461	23	found	find	VBN
cord-023168-cd7adns8	1461	24	.	.	.
cord-023168-cd7adns8	1462	1	They	-PRON-	PRP
cord-023168-cd7adns8	1462	2	are	be	VBP
cord-023168-cd7adns8	1462	3	due	due	JJ
cord-023168-cd7adns8	1462	4	to	to	IN
cord-023168-cd7adns8	1462	5	the	the	DT
cord-023168-cd7adns8	1462	6	recipient	recipient	NN
cord-023168-cd7adns8	1462	7	's	's	POS
cord-023168-cd7adns8	1462	8	antibodies	antibody	NNS
cord-023168-cd7adns8	1462	9	reacting	react	VBG
cord-023168-cd7adns8	1462	10	against	against	IN
cord-023168-cd7adns8	1462	11	antigens	antigen	NNS
cord-023168-cd7adns8	1462	12	present	present	JJ
cord-023168-cd7adns8	1462	13	on	on	IN
cord-023168-cd7adns8	1462	14	the	the	DT
cord-023168-cd7adns8	1462	15	donor	donor	NN
cord-023168-cd7adns8	1462	16	's	's	POS
cord-023168-cd7adns8	1462	17	white	white	JJ
cord-023168-cd7adns8	1462	18	cells	cell	NNS
cord-023168-cd7adns8	1462	19	or	or	CC
cord-023168-cd7adns8	1462	20	platelets	platelet	NNS
cord-023168-cd7adns8	1462	21	.	.	.
cord-023168-cd7adns8	1463	1	These	these	DT
cord-023168-cd7adns8	1463	2	reactions	reaction	NNS
cord-023168-cd7adns8	1463	3	are	be	VBP
cord-023168-cd7adns8	1463	4	most	most	RBS
cord-023168-cd7adns8	1463	5	common	common	JJ
cord-023168-cd7adns8	1463	6	in	in	IN
cord-023168-cd7adns8	1463	7	patients	patient	NNS
cord-023168-cd7adns8	1463	8	who	who	WP
cord-023168-cd7adns8	1463	9	have	have	VBP
cord-023168-cd7adns8	1463	10	had	have	VBN
cord-023168-cd7adns8	1463	11	transfusions	transfusion	NNS
cord-023168-cd7adns8	1463	12	in	in	IN
cord-023168-cd7adns8	1463	13	the	the	DT
cord-023168-cd7adns8	1463	14	past	past	NN
cord-023168-cd7adns8	1463	15	and	and	CC
cord-023168-cd7adns8	1463	16	have	have	VBP
cord-023168-cd7adns8	1463	17	therefore	therefore	RB
cord-023168-cd7adns8	1463	18	been	be	VBN
cord-023168-cd7adns8	1463	19	exposed	expose	VBN
cord-023168-cd7adns8	1463	20	to	to	IN
cord-023168-cd7adns8	1463	21	allo	allo	NN
cord-023168-cd7adns8	1463	22	-	-	HYPH
cord-023168-cd7adns8	1463	23	antigens	antigen	NNS
cord-023168-cd7adns8	1463	24	.	.	.
cord-023168-cd7adns8	1464	1	Mild	mild	JJ
cord-023168-cd7adns8	1464	2	febrile	febrile	JJ
cord-023168-cd7adns8	1464	3	reactions	reaction	NNS
cord-023168-cd7adns8	1464	4	usually	usually	RB
cord-023168-cd7adns8	1464	5	respond	respond	VBP
cord-023168-cd7adns8	1464	6	to	to	IN
cord-023168-cd7adns8	1464	7	simple	simple	JJ
cord-023168-cd7adns8	1464	8	antipyretics	antipyretic	NNS
cord-023168-cd7adns8	1464	9	such	such	JJ
cord-023168-cd7adns8	1464	10	as	as	IN
cord-023168-cd7adns8	1464	11	paracetamol	paracetamol	NNP
cord-023168-cd7adns8	1464	12	.	.	.
cord-023168-cd7adns8	1465	1	More	More	JJR
cord-023168-cd7adns8	1465	2	severe	severe	JJ
cord-023168-cd7adns8	1465	3	reactions	reaction	NNS
cord-023168-cd7adns8	1465	4	may	may	MD
cord-023168-cd7adns8	1465	5	be	be	VB
cord-023168-cd7adns8	1465	6	the	the	DT
cord-023168-cd7adns8	1465	7	first	first	JJ
cord-023168-cd7adns8	1465	8	indication	indication	NN
cord-023168-cd7adns8	1465	9	of	of	IN
cord-023168-cd7adns8	1465	10	a	a	DT
cord-023168-cd7adns8	1465	11	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1465	12	transfusion	transfusion	NN
cord-023168-cd7adns8	1465	13	reaction	reaction	NN
cord-023168-cd7adns8	1465	14	or	or	CC
cord-023168-cd7adns8	1465	15	Anaemia	anaemia	NN
cord-023168-cd7adns8	1465	16	in	in	IN
cord-023168-cd7adns8	1465	17	low	low	JJ
cord-023168-cd7adns8	1465	18	-	-	HYPH
cord-023168-cd7adns8	1465	19	income	income	NN
cord-023168-cd7adns8	1465	20	and	and	CC
cord-023168-cd7adns8	1465	21	middle	middle	JJ
cord-023168-cd7adns8	1465	22	-	-	HYPH
cord-023168-cd7adns8	1465	23	income	income	NN
cord-023168-cd7adns8	1465	24	countries	country	NNS
cord-023168-cd7adns8	1465	25	Sickle	Sickle	NNP
cord-023168-cd7adns8	1465	26	cell	cell	NN
cord-023168-cd7adns8	1465	27	disease	disease	NN
cord-023168-cd7adns8	1466	1	The	the	DT
cord-023168-cd7adns8	1466	2	inherited	inherit	VBN
cord-023168-cd7adns8	1466	3	diseases	disease	NNS
cord-023168-cd7adns8	1466	4	of	of	IN
cord-023168-cd7adns8	1466	5	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1466	6	are	be	VBP
cord-023168-cd7adns8	1466	7	an	an	DT
cord-023168-cd7adns8	1466	8	emerging	emerge	VBG
cord-023168-cd7adns8	1466	9	global	global	JJ
cord-023168-cd7adns8	1466	10	health	health	NN
cord-023168-cd7adns8	1466	11	burden	burden	NN
cord-023168-cd7adns8	1466	12	How	how	WRB
cord-023168-cd7adns8	1466	13	I	-PRON-	PRP
cord-023168-cd7adns8	1466	14	treat	treat	VBP
cord-023168-cd7adns8	1466	15	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1466	16	Blood	blood	NN
cord-023168-cd7adns8	1466	17	donors	donor	NNS
cord-023168-cd7adns8	1466	18	and	and	CC
cord-023168-cd7adns8	1466	19	blood	blood	NN
cord-023168-cd7adns8	1466	20	collecton	collecton	NN
cord-023168-cd7adns8	1466	21	:	:	:
cord-023168-cd7adns8	1467	1	Web	web	NN
cord-023168-cd7adns8	1467	2	interface	interface	NN
cord-023168-cd7adns8	1467	3	-	-	HYPH
cord-023168-cd7adns8	1467	4	supported	support	VBN
cord-023168-cd7adns8	1467	5	transmission	transmission	NN
cord-023168-cd7adns8	1467	6	risk	risk	NN
cord-023168-cd7adns8	1467	7	assessment	assessment	NN
cord-023168-cd7adns8	1467	8	and	and	CC
cord-023168-cd7adns8	1467	9	cost	cost	NN
cord-023168-cd7adns8	1467	10	-	-	HYPH
cord-023168-cd7adns8	1467	11	effectiveness	effectiveness	NN
cord-023168-cd7adns8	1467	12	analysis	analysis	NN
cord-023168-cd7adns8	1467	13	of	of	IN
cord-023168-cd7adns8	1467	14	postdonation	postdonation	NN
cord-023168-cd7adns8	1467	15	screening	screening	NN
cord-023168-cd7adns8	1467	16	:	:	:
cord-023168-cd7adns8	1467	17	a	a	DT
cord-023168-cd7adns8	1467	18	global	global	JJ
cord-023168-cd7adns8	1467	19	model	model	NN
cord-023168-cd7adns8	1467	20	applied	apply	VBN
cord-023168-cd7adns8	1467	21	to	to	IN
cord-023168-cd7adns8	1467	22	REFERENCES	references	NN
cord-023168-cd7adns8	1467	23	1	1	CD
cord-023168-cd7adns8	1467	24	.	.	.
cord-023168-cd7adns8	1468	1	Dale	Dale	NNP
cord-023168-cd7adns8	1468	2	DC	DC	NNP
cord-023168-cd7adns8	1468	3	.	.	.
cord-023168-cd7adns8	1469	1	Neutropenia	neutropenia	NN
cord-023168-cd7adns8	1469	2	and	and	CC
cord-023168-cd7adns8	1469	3	neutrophilia	neutrophilia	NNP
cord-023168-cd7adns8	1469	4	Diagnosis	Diagnosis	NNP
cord-023168-cd7adns8	1469	5	and	and	CC
cord-023168-cd7adns8	1469	6	outcome	outcome	NN
cord-023168-cd7adns8	1469	7	of	of	IN
cord-023168-cd7adns8	1469	8	100	100	CD
cord-023168-cd7adns8	1469	9	consecutive	consecutive	JJ
cord-023168-cd7adns8	1469	10	patients	patient	NNS
cord-023168-cd7adns8	1469	11	with	with	IN
cord-023168-cd7adns8	1469	12	extreme	extreme	JJ
cord-023168-cd7adns8	1469	13	granulocytic	granulocytic	JJ
cord-023168-cd7adns8	1469	14	leukocytosis	leukocytosis	NN
cord-023168-cd7adns8	1470	1	The	the	DT
cord-023168-cd7adns8	1470	2	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	1470	3	value	value	NN
cord-023168-cd7adns8	1470	4	of	of	IN
cord-023168-cd7adns8	1470	5	the	the	DT
cord-023168-cd7adns8	1470	6	neutrophil	neutrophil	NN
cord-023168-cd7adns8	1470	7	left	leave	VBN
cord-023168-cd7adns8	1470	8	shift	shift	NN
cord-023168-cd7adns8	1470	9	in	in	IN
cord-023168-cd7adns8	1470	10	predicting	predict	VBG
cord-023168-cd7adns8	1470	11	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	1470	12	and	and	CC
cord-023168-cd7adns8	1470	13	infectious	infectious	JJ
cord-023168-cd7adns8	1470	14	disease	disease	NN
cord-023168-cd7adns8	1470	15	Congenital	Congenital	NNP
cord-023168-cd7adns8	1470	16	and	and	CC
cord-023168-cd7adns8	1470	17	acquired	acquire	VBD
cord-023168-cd7adns8	1470	18	neutropenia	neutropenia	NNP
cord-023168-cd7adns8	1470	19	Practical	practical	JJ
cord-023168-cd7adns8	1470	20	approach	approach	NN
cord-023168-cd7adns8	1470	21	to	to	IN
cord-023168-cd7adns8	1470	22	the	the	DT
cord-023168-cd7adns8	1470	23	patient	patient	NN
cord-023168-cd7adns8	1470	24	with	with	IN
cord-023168-cd7adns8	1470	25	hypereosinophilia	hypereosinophilia	NNP
cord-023168-cd7adns8	1470	26	Eosinophilia	Eosinophilia	NNP
cord-023168-cd7adns8	1470	27	in	in	IN
cord-023168-cd7adns8	1470	28	returning	return	VBG
cord-023168-cd7adns8	1470	29	travellers	traveller	NNS
cord-023168-cd7adns8	1470	30	and	and	CC
cord-023168-cd7adns8	1470	31	migrants	migrant	NNS
cord-023168-cd7adns8	1470	32	from	from	IN
cord-023168-cd7adns8	1470	33	the	the	DT
cord-023168-cd7adns8	1470	34	tropics	tropic	NNS
cord-023168-cd7adns8	1470	35	:	:	:
cord-023168-cd7adns8	1471	1	UK	UK	NNP
cord-023168-cd7adns8	1471	2	recommendations	recommendation	NNS
cord-023168-cd7adns8	1471	3	for	for	IN
cord-023168-cd7adns8	1471	4	investigation	investigation	NN
cord-023168-cd7adns8	1471	5	and	and	CC
cord-023168-cd7adns8	1471	6	initial	initial	JJ
cord-023168-cd7adns8	1471	7	management	management	NN
cord-023168-cd7adns8	1471	8	Investigation	Investigation	NNP
cord-023168-cd7adns8	1471	9	of	of	IN
cord-023168-cd7adns8	1471	10	tropical	tropical	JJ
cord-023168-cd7adns8	1471	11	eosinophilia	eosinophilia	NN
cord-023168-cd7adns8	1471	12	;	;	:
cord-023168-cd7adns8	1471	13	assessing	assess	VBG
cord-023168-cd7adns8	1471	14	a	a	DT
cord-023168-cd7adns8	1471	15	strategy	strategy	NN
cord-023168-cd7adns8	1471	16	based	base	VBN
cord-023168-cd7adns8	1471	17	on	on	IN
cord-023168-cd7adns8	1471	18	geographical	geographical	JJ
cord-023168-cd7adns8	1471	19	area	area	NN
cord-023168-cd7adns8	1471	20	Worldwide	worldwide	JJ
cord-023168-cd7adns8	1471	21	prevalence	prevalence	NN
cord-023168-cd7adns8	1471	22	of	of	IN
cord-023168-cd7adns8	1471	23	anaemia	anaemia	NN
cord-023168-cd7adns8	1471	24	,	,	,
cord-023168-cd7adns8	1472	1	WHO	who	WP
cord-023168-cd7adns8	1472	2	Vitamin	vitamin	NN
cord-023168-cd7adns8	1472	3	and	and	CC
cord-023168-cd7adns8	1472	4	Mineral	Mineral	NNP
cord-023168-cd7adns8	1472	5	Nutrition	Nutrition	NNP
cord-023168-cd7adns8	1472	6	Information	Information	NNP
cord-023168-cd7adns8	1472	7	System	System	NNP
cord-023168-cd7adns8	1472	8	Comparative	Comparative	NNP
cord-023168-cd7adns8	1472	9	Quantification	quantification	NN
cord-023168-cd7adns8	1472	10	of	of	IN
cord-023168-cd7adns8	1472	11	Health	Health	NNP
cord-023168-cd7adns8	1472	12	Risks	Risks	NNPS
cord-023168-cd7adns8	1472	13	:	:	:
cord-023168-cd7adns8	1472	14	Global	Global	NNP
cord-023168-cd7adns8	1472	15	and	and	CC
cord-023168-cd7adns8	1472	16	Regional	Regional	NNP
cord-023168-cd7adns8	1472	17	Burden	Burden	NNP
cord-023168-cd7adns8	1472	18	of	of	IN
cord-023168-cd7adns8	1472	19	Disease	Disease	NNP
cord-023168-cd7adns8	1472	20	Attributable	attributable	JJ
cord-023168-cd7adns8	1472	21	to	to	IN
cord-023168-cd7adns8	1472	22	Selected	Selected	NNP
cord-023168-cd7adns8	1472	23	Major	Major	NNP
cord-023168-cd7adns8	1472	24	Risk	Risk	NNP
cord-023168-cd7adns8	1472	25	Factors	Factors	NNP
cord-023168-cd7adns8	1472	26	.	.	.
cord-023168-cd7adns8	1473	1	Geneva	Geneva	NNP
cord-023168-cd7adns8	1473	2	:	:	:
cord-023168-cd7adns8	1474	1	World	World	NNP
cord-023168-cd7adns8	1474	2	Health	Health	NNP
cord-023168-cd7adns8	1474	3	Organization	Organization	NNP
cord-023168-cd7adns8	1474	4	Worldwide	Worldwide	NNP
cord-023168-cd7adns8	1474	5	prevalence	prevalence	NN
cord-023168-cd7adns8	1474	6	of	of	IN
cord-023168-cd7adns8	1474	7	anaemia	anaemia	NN
cord-023168-cd7adns8	1474	8	1993	1993	CD
cord-023168-cd7adns8	1474	9	-	-	SYM
cord-023168-cd7adns8	1474	10	2005	2005	CD
cord-023168-cd7adns8	1474	11	:	:	:
cord-023168-cd7adns8	1475	1	WHO	WHO	NNP
cord-023168-cd7adns8	1475	2	Global	Global	NNP
cord-023168-cd7adns8	1475	3	Database	Database	NNP
cord-023168-cd7adns8	1475	4	on	on	IN
cord-023168-cd7adns8	1475	5	Anaemia	Anaemia	NNP
cord-023168-cd7adns8	1475	6	.	.	.
cord-023168-cd7adns8	1476	1	Geneva	Geneva	NNP
cord-023168-cd7adns8	1476	2	:	:	:
cord-023168-cd7adns8	1477	1	World	World	NNP
cord-023168-cd7adns8	1477	2	Health	Health	NNP
cord-023168-cd7adns8	1477	3	Organization	Organization	NNP
cord-023168-cd7adns8	1477	4	Anaemia	Anaemia	NNP
cord-023168-cd7adns8	1477	5	in	in	IN
cord-023168-cd7adns8	1477	6	low	low	JJ
cord-023168-cd7adns8	1477	7	-	-	HYPH
cord-023168-cd7adns8	1477	8	income	income	NN
cord-023168-cd7adns8	1477	9	and	and	CC
cord-023168-cd7adns8	1477	10	middle	middle	JJ
cord-023168-cd7adns8	1477	11	-	-	HYPH
cord-023168-cd7adns8	1477	12	income	income	NN
cord-023168-cd7adns8	1477	13	countries	country	NNS
cord-023168-cd7adns8	1477	14	Accuracy	accuracy	NN
cord-023168-cd7adns8	1477	15	of	of	IN
cord-023168-cd7adns8	1477	16	clinical	clinical	JJ
cord-023168-cd7adns8	1477	17	pallor	pallor	NN
cord-023168-cd7adns8	1477	18	in	in	IN
cord-023168-cd7adns8	1477	19	the	the	DT
cord-023168-cd7adns8	1477	20	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1477	21	of	of	IN
cord-023168-cd7adns8	1477	22	anaemia	anaemia	NN
cord-023168-cd7adns8	1477	23	in	in	IN
cord-023168-cd7adns8	1477	24	children	child	NNS
cord-023168-cd7adns8	1477	25	:	:	:
cord-023168-cd7adns8	1478	1	a	a	DT
cord-023168-cd7adns8	1478	2	meta	meta	JJ
cord-023168-cd7adns8	1478	3	-	-	HYPH
cord-023168-cd7adns8	1478	4	analysis	analysis	NN
cord-023168-cd7adns8	1478	5	Clinical	clinical	JJ
cord-023168-cd7adns8	1478	6	pallor	pallor	NN
cord-023168-cd7adns8	1478	7	is	be	VBZ
cord-023168-cd7adns8	1478	8	useful	useful	JJ
cord-023168-cd7adns8	1478	9	to	to	TO
cord-023168-cd7adns8	1478	10	detect	detect	VB
cord-023168-cd7adns8	1478	11	severe	severe	JJ
cord-023168-cd7adns8	1478	12	anemia	anemia	NN
cord-023168-cd7adns8	1478	13	in	in	IN
cord-023168-cd7adns8	1478	14	populations	population	NNS
cord-023168-cd7adns8	1478	15	where	where	WRB
cord-023168-cd7adns8	1478	16	anemia	anemia	NN
cord-023168-cd7adns8	1478	17	is	be	VBZ
cord-023168-cd7adns8	1478	18	prevalent	prevalent	JJ
cord-023168-cd7adns8	1478	19	and	and	CC
cord-023168-cd7adns8	1478	20	severe	severe	JJ
cord-023168-cd7adns8	1478	21	Anaemia	anaemia	NN
cord-023168-cd7adns8	1478	22	:	:	:
cord-023168-cd7adns8	1478	23	a	a	DT
cord-023168-cd7adns8	1478	24	useful	useful	JJ
cord-023168-cd7adns8	1478	25	indicator	indicator	NN
cord-023168-cd7adns8	1478	26	of	of	IN
cord-023168-cd7adns8	1478	27	neglected	neglect	VBN
cord-023168-cd7adns8	1478	28	disease	disease	NN
cord-023168-cd7adns8	1478	29	burden	burden	NN
cord-023168-cd7adns8	1478	30	and	and	CC
cord-023168-cd7adns8	1478	31	control	control	NN
cord-023168-cd7adns8	1478	32	Estimating	estimate	VBG
cord-023168-cd7adns8	1478	33	the	the	DT
cord-023168-cd7adns8	1478	34	prevalence	prevalence	NN
cord-023168-cd7adns8	1478	35	of	of	IN
cord-023168-cd7adns8	1478	36	anaemia	anaemia	NN
cord-023168-cd7adns8	1478	37	:	:	:
cord-023168-cd7adns8	1478	38	a	a	DT
cord-023168-cd7adns8	1478	39	comparison	comparison	NN
cord-023168-cd7adns8	1478	40	of	of	IN
cord-023168-cd7adns8	1478	41	three	three	CD
cord-023168-cd7adns8	1478	42	methods	method	NNS
cord-023168-cd7adns8	1478	43	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1478	44	colour	colour	NN
cord-023168-cd7adns8	1478	45	scale	scale	NN
cord-023168-cd7adns8	1478	46	for	for	IN
cord-023168-cd7adns8	1478	47	anaemia	anaemia	NN
cord-023168-cd7adns8	1478	48	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1478	49	where	where	WRB
cord-023168-cd7adns8	1478	50	there	there	EX
cord-023168-cd7adns8	1478	51	is	be	VBZ
cord-023168-cd7adns8	1478	52	no	no	DT
cord-023168-cd7adns8	1478	53	laboratory	laboratory	NN
cord-023168-cd7adns8	1478	54	:	:	:
cord-023168-cd7adns8	1478	55	a	a	DT
cord-023168-cd7adns8	1478	56	systematic	systematic	JJ
cord-023168-cd7adns8	1478	57	review	review	NN
cord-023168-cd7adns8	1478	58	Late	late	RB
cord-023168-cd7adns8	1478	59	vs	vs	IN
cord-023168-cd7adns8	1478	60	early	early	JJ
cord-023168-cd7adns8	1478	61	clamping	clamping	NN
cord-023168-cd7adns8	1478	62	of	of	IN
cord-023168-cd7adns8	1478	63	the	the	DT
cord-023168-cd7adns8	1478	64	umbilical	umbilical	JJ
cord-023168-cd7adns8	1478	65	cord	cord	NN
cord-023168-cd7adns8	1478	66	in	in	IN
cord-023168-cd7adns8	1478	67	full	full	JJ
cord-023168-cd7adns8	1478	68	-	-	HYPH
cord-023168-cd7adns8	1478	69	term	term	NN
cord-023168-cd7adns8	1478	70	neonates	neonate	NNS
cord-023168-cd7adns8	1478	71	:	:	:
cord-023168-cd7adns8	1478	72	systematic	systematic	JJ
cord-023168-cd7adns8	1478	73	review	review	NN
cord-023168-cd7adns8	1478	74	and	and	CC
cord-023168-cd7adns8	1478	75	meta	meta	NNP
cord-023168-cd7adns8	1478	76	-	-	HYPH
cord-023168-cd7adns8	1478	77	analysis	analysis	NN
cord-023168-cd7adns8	1478	78	of	of	IN
cord-023168-cd7adns8	1478	79	controlled	control	VBN
cord-023168-cd7adns8	1478	80	trials	trial	NNS
cord-023168-cd7adns8	1479	1	What	what	WP
cord-023168-cd7adns8	1479	2	works	work	VBZ
cord-023168-cd7adns8	1479	3	?	?	.
cord-023168-cd7adns8	1480	1	Interventions	intervention	NNS
cord-023168-cd7adns8	1480	2	for	for	IN
cord-023168-cd7adns8	1480	3	maternal	maternal	JJ
cord-023168-cd7adns8	1480	4	and	and	CC
cord-023168-cd7adns8	1480	5	child	child	NN
cord-023168-cd7adns8	1480	6	undernutrition	undernutrition	NN
cord-023168-cd7adns8	1480	7	and	and	CC
cord-023168-cd7adns8	1480	8	survival	survival	NN
cord-023168-cd7adns8	1480	9	Iron	iron	NN
cord-023168-cd7adns8	1480	10	in	in	IN
cord-023168-cd7adns8	1480	11	fetal	fetal	JJ
cord-023168-cd7adns8	1480	12	and	and	CC
cord-023168-cd7adns8	1480	13	neonatal	neonatal	JJ
cord-023168-cd7adns8	1480	14	nutrition	nutrition	NN
cord-023168-cd7adns8	1480	15	Global	Global	NNP
cord-023168-cd7adns8	1480	16	health	health	NN
cord-023168-cd7adns8	1480	17	risks	risk	NNS
cord-023168-cd7adns8	1480	18	.	.	.
cord-023168-cd7adns8	1481	1	Mortality	mortality	NN
cord-023168-cd7adns8	1481	2	and	and	CC
cord-023168-cd7adns8	1481	3	burden	burden	NN
cord-023168-cd7adns8	1481	4	of	of	IN
cord-023168-cd7adns8	1481	5	disease	disease	NN
cord-023168-cd7adns8	1481	6	attributable	attributable	JJ
cord-023168-cd7adns8	1481	7	to	to	IN
cord-023168-cd7adns8	1481	8	selected	select	VBN
cord-023168-cd7adns8	1481	9	major	major	JJ
cord-023168-cd7adns8	1481	10	risk	risk	NN
cord-023168-cd7adns8	1481	11	factors	factor	NNS
cord-023168-cd7adns8	1482	1	Weekly	weekly	JJ
cord-023168-cd7adns8	1482	2	iron	iron	NN
cord-023168-cd7adns8	1482	3	-	-	HYPH
cord-023168-cd7adns8	1482	4	folic	folic	NN
cord-023168-cd7adns8	1482	5	acid	acid	NN
cord-023168-cd7adns8	1482	6	supplementation	supplementation	NN
cord-023168-cd7adns8	1482	7	(	(	-LRB-
cord-023168-cd7adns8	1482	8	WIFS	WIFS	NNP
cord-023168-cd7adns8	1482	9	)	)	-RRB-
cord-023168-cd7adns8	1482	10	in	in	IN
cord-023168-cd7adns8	1482	11	women	woman	NNS
cord-023168-cd7adns8	1482	12	of	of	IN
cord-023168-cd7adns8	1482	13	reproductive	reproductive	JJ
cord-023168-cd7adns8	1482	14	age	age	NN
cord-023168-cd7adns8	1482	15	:	:	:
cord-023168-cd7adns8	1482	16	its	-PRON-	PRP$
cord-023168-cd7adns8	1482	17	role	role	NN
cord-023168-cd7adns8	1482	18	in	in	IN
cord-023168-cd7adns8	1482	19	promoting	promote	VBG
cord-023168-cd7adns8	1482	20	optimal	optimal	JJ
cord-023168-cd7adns8	1482	21	maternal	maternal	JJ
cord-023168-cd7adns8	1482	22	and	and	CC
cord-023168-cd7adns8	1482	23	child	child	NN
cord-023168-cd7adns8	1482	24	health	health	NN
cord-023168-cd7adns8	1482	25	Iron	Iron	NNP
cord-023168-cd7adns8	1482	26	Interventions	Interventions	NNPS
cord-023168-cd7adns8	1482	27	for	for	IN
cord-023168-cd7adns8	1482	28	women	woman	NNS
cord-023168-cd7adns8	1482	29	and	and	CC
cord-023168-cd7adns8	1482	30	children	child	NNS
cord-023168-cd7adns8	1482	31	in	in	IN
cord-023168-cd7adns8	1482	32	low	low	JJ
cord-023168-cd7adns8	1482	33	-	-	HYPH
cord-023168-cd7adns8	1482	34	income	income	NN
cord-023168-cd7adns8	1482	35	countries	country	NNS
cord-023168-cd7adns8	1483	1	How	how	WRB
cord-023168-cd7adns8	1483	2	much	much	JJ
cord-023168-cd7adns8	1483	3	time	time	NN
cord-023168-cd7adns8	1483	4	do	do	VBP
cord-023168-cd7adns8	1483	5	health	health	NN
cord-023168-cd7adns8	1483	6	services	service	NNS
cord-023168-cd7adns8	1483	7	spend	spend	VB
cord-023168-cd7adns8	1483	8	on	on	IN
cord-023168-cd7adns8	1483	9	antenatal	antenatal	JJ
cord-023168-cd7adns8	1483	10	care	care	NN
cord-023168-cd7adns8	1483	11	?	?	.
cord-023168-cd7adns8	1484	1	Implications	implication	NNS
cord-023168-cd7adns8	1484	2	for	for	IN
cord-023168-cd7adns8	1484	3	the	the	DT
cord-023168-cd7adns8	1484	4	introduction	introduction	NN
cord-023168-cd7adns8	1484	5	of	of	IN
cord-023168-cd7adns8	1484	6	the	the	DT
cord-023168-cd7adns8	1484	7	focused	focused	JJ
cord-023168-cd7adns8	1484	8	antenatal	antenatal	JJ
cord-023168-cd7adns8	1484	9	care	care	NN
cord-023168-cd7adns8	1484	10	model	model	NN
cord-023168-cd7adns8	1484	11	in	in	IN
cord-023168-cd7adns8	1484	12	Tanzania	Tanzania	NNP
cord-023168-cd7adns8	1484	13	Efficacy	Efficacy	NNP
cord-023168-cd7adns8	1484	14	and	and	CC
cord-023168-cd7adns8	1484	15	trial	trial	NN
cord-023168-cd7adns8	1484	16	effectiveness	effectiveness	NN
cord-023168-cd7adns8	1484	17	of	of	IN
cord-023168-cd7adns8	1484	18	weekly	weekly	JJ
cord-023168-cd7adns8	1484	19	and	and	CC
cord-023168-cd7adns8	1484	20	daily	daily	JJ
cord-023168-cd7adns8	1484	21	iron	iron	NN
cord-023168-cd7adns8	1484	22	supplementation	supplementation	NN
cord-023168-cd7adns8	1484	23	among	among	IN
cord-023168-cd7adns8	1484	24	pregnant	pregnant	JJ
cord-023168-cd7adns8	1484	25	women	woman	NNS
cord-023168-cd7adns8	1484	26	in	in	IN
cord-023168-cd7adns8	1484	27	rural	rural	JJ
cord-023168-cd7adns8	1484	28	Bangladesh	Bangladesh	NNP
cord-023168-cd7adns8	1484	29	:	:	:
cord-023168-cd7adns8	1484	30	disentangling	disentangle	VBG
cord-023168-cd7adns8	1484	31	the	the	DT
cord-023168-cd7adns8	1484	32	issues	issue	NNS
cord-023168-cd7adns8	1484	33	Diagnosis	diagnosis	NN
cord-023168-cd7adns8	1484	34	and	and	CC
cord-023168-cd7adns8	1484	35	management	management	NN
cord-023168-cd7adns8	1484	36	of	of	IN
cord-023168-cd7adns8	1484	37	irondeficiency	irondeficiency	NNP
cord-023168-cd7adns8	1484	38	anaemia	anaemia	NN
cord-023168-cd7adns8	1484	39	Iron	Iron	NNP
cord-023168-cd7adns8	1484	40	deficiency	deficiency	NN
cord-023168-cd7adns8	1484	41	and	and	CC
cord-023168-cd7adns8	1484	42	overload	overload	NN
cord-023168-cd7adns8	1484	43	Iron	Iron	NNP
cord-023168-cd7adns8	1484	44	deficiency	deficiency	NN
cord-023168-cd7adns8	1484	45	anemia	anemia	NN
cord-023168-cd7adns8	1484	46	Iron	Iron	NNP
cord-023168-cd7adns8	1484	47	deficiency	deficiency	NN
cord-023168-cd7adns8	1484	48	:	:	:
cord-023168-cd7adns8	1484	49	a	a	DT
cord-023168-cd7adns8	1484	50	concise	concise	JJ
cord-023168-cd7adns8	1484	51	review	review	NN
cord-023168-cd7adns8	1485	1	Individualized	individualized	JJ
cord-023168-cd7adns8	1485	2	treatment	treatment	NN
cord-023168-cd7adns8	1485	3	for	for	IN
cord-023168-cd7adns8	1485	4	iron	iron	NN
cord-023168-cd7adns8	1485	5	-	-	HYPH
cord-023168-cd7adns8	1485	6	deficiency	deficiency	NN
cord-023168-cd7adns8	1485	7	anemia	anemia	NN
cord-023168-cd7adns8	1485	8	in	in	IN
cord-023168-cd7adns8	1485	9	adults	adult	NNS
cord-023168-cd7adns8	1485	10	Clinical	clinical	JJ
cord-023168-cd7adns8	1485	11	update	update	NN
cord-023168-cd7adns8	1485	12	:	:	:
cord-023168-cd7adns8	1486	1	intravenous	intravenous	JJ
cord-023168-cd7adns8	1486	2	iron	iron	NN
cord-023168-cd7adns8	1486	3	for	for	IN
cord-023168-cd7adns8	1486	4	anaemia	anaemia	NN
cord-023168-cd7adns8	1486	5	Laboratory	Laboratory	NNP
cord-023168-cd7adns8	1486	6	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1486	7	of	of	IN
cord-023168-cd7adns8	1486	8	vitamin	vitamin	NN
cord-023168-cd7adns8	1486	9	B	b	NN
cord-023168-cd7adns8	1486	10	12	12	CD
cord-023168-cd7adns8	1486	11	and	and	CC
cord-023168-cd7adns8	1486	12	folate	folate	JJ
cord-023168-cd7adns8	1486	13	deficiency	deficiency	NN
cord-023168-cd7adns8	1486	14	Plasma	plasma	NN
cord-023168-cd7adns8	1486	15	homocysteine	homocysteine	NN
cord-023168-cd7adns8	1486	16	levels	level	NNS
cord-023168-cd7adns8	1486	17	and	and	CC
cord-023168-cd7adns8	1486	18	mortality	mortality	NN
cord-023168-cd7adns8	1486	19	in	in	IN
cord-023168-cd7adns8	1486	20	patients	patient	NNS
cord-023168-cd7adns8	1486	21	with	with	IN
cord-023168-cd7adns8	1486	22	coronary	coronary	JJ
cord-023168-cd7adns8	1486	23	artery	artery	NN
cord-023168-cd7adns8	1486	24	disease	disease	NN
cord-023168-cd7adns8	1487	1	How	how	WRB
cord-023168-cd7adns8	1487	2	I	-PRON-	PRP
cord-023168-cd7adns8	1487	3	treat	treat	VBP
cord-023168-cd7adns8	1487	4	cobalamin	cobalamin	NN
cord-023168-cd7adns8	1487	5	(	(	-LRB-
cord-023168-cd7adns8	1487	6	vitamin	vitamin	NN
cord-023168-cd7adns8	1487	7	B	b	NN
cord-023168-cd7adns8	1487	8	12	12	CD
cord-023168-cd7adns8	1487	9	)	)	-RRB-
cord-023168-cd7adns8	1487	10	deficiency	deficiency	NN
cord-023168-cd7adns8	1487	11	Vitamin	vitamin	NN
cord-023168-cd7adns8	1487	12	B	b	NN
cord-023168-cd7adns8	1487	13	12	12	CD
cord-023168-cd7adns8	1487	14	deficiency	deficiency	NN
cord-023168-cd7adns8	1487	15	Sensitivity	sensitivity	NN
cord-023168-cd7adns8	1487	16	of	of	IN
cord-023168-cd7adns8	1487	17	serum	serum	NN
cord-023168-cd7adns8	1487	18	methylmalonic	methylmalonic	NN
cord-023168-cd7adns8	1487	19	acid	acid	NN
cord-023168-cd7adns8	1487	20	and	and	CC
cord-023168-cd7adns8	1487	21	total	total	JJ
cord-023168-cd7adns8	1487	22	homocysteine	homocysteine	JJ
cord-023168-cd7adns8	1487	23	determinations	determination	NNS
cord-023168-cd7adns8	1487	24	for	for	IN
cord-023168-cd7adns8	1487	25	diagnosing	diagnose	VBG
cord-023168-cd7adns8	1487	26	cobalamin	cobalamin	NN
cord-023168-cd7adns8	1487	27	and	and	CC
cord-023168-cd7adns8	1487	28	folate	folate	NN
cord-023168-cd7adns8	1487	29	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1488	1	Oral	oral	JJ
cord-023168-cd7adns8	1488	2	or	or	CC
cord-023168-cd7adns8	1488	3	parenteral	parenteral	JJ
cord-023168-cd7adns8	1488	4	therapy	therapy	NN
cord-023168-cd7adns8	1488	5	for	for	IN
cord-023168-cd7adns8	1488	6	B	b	NN
cord-023168-cd7adns8	1488	7	12	12	CD
cord-023168-cd7adns8	1488	8	deficiency	deficiency	NN
cord-023168-cd7adns8	1489	1	Effective	effective	JJ
cord-023168-cd7adns8	1489	2	treatment	treatment	NN
cord-023168-cd7adns8	1489	3	of	of	IN
cord-023168-cd7adns8	1489	4	cobalamin	cobalamin	NN
cord-023168-cd7adns8	1489	5	deficiency	deficiency	NN
cord-023168-cd7adns8	1489	6	with	with	IN
cord-023168-cd7adns8	1489	7	oral	oral	JJ
cord-023168-cd7adns8	1489	8	cobalamin	cobalamin	NN
cord-023168-cd7adns8	1489	9	High	high	JJ
cord-023168-cd7adns8	1489	10	prevalence	prevalence	NN
cord-023168-cd7adns8	1489	11	of	of	IN
cord-023168-cd7adns8	1489	12	cobalamin	cobalamin	NN
cord-023168-cd7adns8	1489	13	deficiency	deficiency	NN
cord-023168-cd7adns8	1489	14	in	in	IN
cord-023168-cd7adns8	1489	15	elderly	elderly	JJ
cord-023168-cd7adns8	1489	16	outpatients	outpatient	NNS
cord-023168-cd7adns8	1489	17	Vitamin	vitamin	NN
cord-023168-cd7adns8	1489	18	B	b	NN
cord-023168-cd7adns8	1489	19	12	12	CD
cord-023168-cd7adns8	1489	20	(	(	-LRB-
cord-023168-cd7adns8	1489	21	cobalamin	cobalamin	NN
cord-023168-cd7adns8	1489	22	)	)	-RRB-
cord-023168-cd7adns8	1489	23	deficiency	deficiency	NN
cord-023168-cd7adns8	1489	24	in	in	IN
cord-023168-cd7adns8	1489	25	elderly	elderly	JJ
cord-023168-cd7adns8	1489	26	patients	patient	NNS
cord-023168-cd7adns8	1489	27	Causes	cause	NNS
cord-023168-cd7adns8	1489	28	of	of	IN
cord-023168-cd7adns8	1489	29	vitamin	vitamin	NN
cord-023168-cd7adns8	1489	30	B	b	NN
cord-023168-cd7adns8	1489	31	12	12	CD
cord-023168-cd7adns8	1489	32	and	and	CC
cord-023168-cd7adns8	1489	33	folate	folate	VB
cord-023168-cd7adns8	1490	1	deficiency	deficiency	NN
cord-023168-cd7adns8	1490	2	Importance	importance	NN
cord-023168-cd7adns8	1490	3	of	of	IN
cord-023168-cd7adns8	1490	4	folate	folate	NN
cord-023168-cd7adns8	1490	5	in	in	IN
cord-023168-cd7adns8	1490	6	human	human	JJ
cord-023168-cd7adns8	1490	7	nutrition	nutrition	NN
cord-023168-cd7adns8	1490	8	Review	Review	NNP
cord-023168-cd7adns8	1490	9	of	of	IN
cord-023168-cd7adns8	1490	10	the	the	DT
cord-023168-cd7adns8	1490	11	magnitude	magnitude	NN
cord-023168-cd7adns8	1490	12	of	of	IN
cord-023168-cd7adns8	1490	13	folate	folate	NN
cord-023168-cd7adns8	1490	14	and	and	CC
cord-023168-cd7adns8	1490	15	vitamin	vitamin	NN
cord-023168-cd7adns8	1490	16	B	b	NN
cord-023168-cd7adns8	1490	17	12	12	CD
cord-023168-cd7adns8	1490	18	deficiencies	deficiency	NNS
cord-023168-cd7adns8	1490	19	worldwide	worldwide	RB
cord-023168-cd7adns8	1490	20	Red	red	JJ
cord-023168-cd7adns8	1490	21	cell	cell	NN
cord-023168-cd7adns8	1490	22	or	or	CC
cord-023168-cd7adns8	1490	23	serum	serum	NN
cord-023168-cd7adns8	1490	24	folate	folate	NN
cord-023168-cd7adns8	1490	25	?	?	.
cord-023168-cd7adns8	1491	1	Results	result	NNS
cord-023168-cd7adns8	1491	2	from	from	IN
cord-023168-cd7adns8	1491	3	the	the	DT
cord-023168-cd7adns8	1491	4	National	National	NNP
cord-023168-cd7adns8	1491	5	Pathology	Pathology	NNP
cord-023168-cd7adns8	1491	6	Alliance	Alliance	NNP
cord-023168-cd7adns8	1491	7	benchmarking	benchmarking	NN
cord-023168-cd7adns8	1491	8	review	review	NN
cord-023168-cd7adns8	1492	1	The	the	DT
cord-023168-cd7adns8	1492	2	anemia	anemia	NN
cord-023168-cd7adns8	1492	3	of	of	IN
cord-023168-cd7adns8	1492	4	vitamin	vitamin	NN
cord-023168-cd7adns8	1492	5	A	a	DT
cord-023168-cd7adns8	1492	6	deficiency	deficiency	NN
cord-023168-cd7adns8	1492	7	:	:	:
cord-023168-cd7adns8	1492	8	epidemiology	epidemiology	NN
cord-023168-cd7adns8	1492	9	and	and	CC
cord-023168-cd7adns8	1492	10	pathogenesis	pathogenesis	NN
cord-023168-cd7adns8	1492	11	Vitamin	vitamin	NN
cord-023168-cd7adns8	1492	12	A	a	NN
cord-023168-cd7adns8	1492	13	or	or	CC
cord-023168-cd7adns8	1492	14	b	b	NN
cord-023168-cd7adns8	1492	15	-	-	HYPH
cord-023168-cd7adns8	1492	16	carotene	carotene	NN
cord-023168-cd7adns8	1492	17	supplementation	supplementation	NN
cord-023168-cd7adns8	1492	18	reduce	reduce	VBP
cord-023168-cd7adns8	1492	19	symptoms	symptom	NNS
cord-023168-cd7adns8	1492	20	of	of	IN
cord-023168-cd7adns8	1492	21	illness	illness	NN
cord-023168-cd7adns8	1492	22	in	in	IN
cord-023168-cd7adns8	1492	23	pregnant	pregnant	JJ
cord-023168-cd7adns8	1492	24	and	and	CC
cord-023168-cd7adns8	1492	25	lactating	lactate	VBG
cord-023168-cd7adns8	1492	26	Nepali	nepali	JJ
cord-023168-cd7adns8	1492	27	women	woman	NNS
cord-023168-cd7adns8	1493	1	Vitamin	vitamin	NN
cord-023168-cd7adns8	1493	2	A	a	DT
cord-023168-cd7adns8	1493	3	intervention	intervention	NN
cord-023168-cd7adns8	1493	4	:	:	:
cord-023168-cd7adns8	1493	5	short	short	JJ
cord-023168-cd7adns8	1493	6	term	term	NN
cord-023168-cd7adns8	1493	7	effects	effect	NNS
cord-023168-cd7adns8	1493	8	of	of	IN
cord-023168-cd7adns8	1493	9	a	a	DT
cord-023168-cd7adns8	1493	10	single	single	JJ
cord-023168-cd7adns8	1493	11	,	,	,
cord-023168-cd7adns8	1493	12	oral	oral	JJ
cord-023168-cd7adns8	1493	13	,	,	,
cord-023168-cd7adns8	1493	14	massive	massive	JJ
cord-023168-cd7adns8	1493	15	dose	dose	NN
cord-023168-cd7adns8	1493	16	on	on	IN
cord-023168-cd7adns8	1493	17	iron	iron	NN
cord-023168-cd7adns8	1493	18	metabolism	metabolism	NN
cord-023168-cd7adns8	1494	1	Supplemental	supplemental	JJ
cord-023168-cd7adns8	1494	2	vitamin	vitamin	NN
cord-023168-cd7adns8	1494	3	A	a	NN
cord-023168-cd7adns8	1494	4	improves	improve	VBZ
cord-023168-cd7adns8	1494	5	anemia	anemia	NN
cord-023168-cd7adns8	1494	6	and	and	CC
cord-023168-cd7adns8	1494	7	growth	growth	NN
cord-023168-cd7adns8	1494	8	in	in	IN
cord-023168-cd7adns8	1494	9	anemic	anemic	JJ
cord-023168-cd7adns8	1494	10	school	school	NN
cord-023168-cd7adns8	1494	11	children	child	NNS
cord-023168-cd7adns8	1494	12	in	in	IN
cord-023168-cd7adns8	1494	13	Tanzania	Tanzania	NNP
cord-023168-cd7adns8	1494	14	Supplementation	Supplementation	NNP
cord-023168-cd7adns8	1494	15	with	with	IN
cord-023168-cd7adns8	1494	16	vitamin	vitamin	NN
cord-023168-cd7adns8	1494	17	A	a	NN
cord-023168-cd7adns8	1494	18	and	and	CC
cord-023168-cd7adns8	1494	19	iron	iron	NN
cord-023168-cd7adns8	1494	20	for	for	IN
cord-023168-cd7adns8	1494	21	nutritional	nutritional	JJ
cord-023168-cd7adns8	1494	22	anaemia	anaemia	NN
cord-023168-cd7adns8	1494	23	in	in	IN
cord-023168-cd7adns8	1494	24	pregnant	pregnant	JJ
cord-023168-cd7adns8	1494	25	women	woman	NNS
cord-023168-cd7adns8	1494	26	in	in	IN
cord-023168-cd7adns8	1494	27	West	West	NNP
cord-023168-cd7adns8	1494	28	Java	Java	NNP
cord-023168-cd7adns8	1494	29	Effect	Effect	NNP
cord-023168-cd7adns8	1494	30	of	of	IN
cord-023168-cd7adns8	1494	31	vitamin	vitamin	NN
cord-023168-cd7adns8	1494	32	A	a	DT
cord-023168-cd7adns8	1494	33	supplementation	supplementation	NN
cord-023168-cd7adns8	1494	34	on	on	IN
cord-023168-cd7adns8	1494	35	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1494	36	and	and	CC
cord-023168-cd7adns8	1494	37	vitamin	vitamin	NN
cord-023168-cd7adns8	1494	38	A	a	DT
cord-023168-cd7adns8	1494	39	levels	level	NNS
cord-023168-cd7adns8	1494	40	during	during	IN
cord-023168-cd7adns8	1494	41	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1494	42	Randomised	randomised	JJ
cord-023168-cd7adns8	1494	43	trial	trial	NN
cord-023168-cd7adns8	1494	44	of	of	IN
cord-023168-cd7adns8	1494	45	vitamin	vitamin	NN
cord-023168-cd7adns8	1494	46	A	a	DT
cord-023168-cd7adns8	1494	47	supplementation	supplementation	NN
cord-023168-cd7adns8	1494	48	in	in	IN
cord-023168-cd7adns8	1494	49	pregnant	pregnant	JJ
cord-023168-cd7adns8	1494	50	women	woman	NNS
cord-023168-cd7adns8	1494	51	in	in	IN
cord-023168-cd7adns8	1494	52	rural	rural	JJ
cord-023168-cd7adns8	1494	53	Malawi	Malawi	NNP
cord-023168-cd7adns8	1494	54	found	find	VBD
cord-023168-cd7adns8	1494	55	to	to	TO
cord-023168-cd7adns8	1494	56	be	be	VB
cord-023168-cd7adns8	1494	57	anaemic	anaemic	JJ
cord-023168-cd7adns8	1494	58	on	on	IN
cord-023168-cd7adns8	1494	59	screening	screening	NN
cord-023168-cd7adns8	1494	60	by	by	IN
cord-023168-cd7adns8	1494	61	HemoCue	HemoCue	NNP
cord-023168-cd7adns8	1494	62	Double	Double	NNP
cord-023168-cd7adns8	1494	63	blind	blind	JJ
cord-023168-cd7adns8	1494	64	randomised	randomised	JJ
cord-023168-cd7adns8	1494	65	trial	trial	NN
cord-023168-cd7adns8	1494	66	of	of	IN
cord-023168-cd7adns8	1494	67	low	low	JJ
cord-023168-cd7adns8	1494	68	dose	dose	NN
cord-023168-cd7adns8	1494	69	supplements	supplement	NNS
cord-023168-cd7adns8	1494	70	with	with	IN
cord-023168-cd7adns8	1494	71	Vitamin	vitamin	NN
cord-023168-cd7adns8	1494	72	A	a	NN
cord-023168-cd7adns8	1494	73	or	or	CC
cord-023168-cd7adns8	1494	74	beta	beta	NN
cord-023168-cd7adns8	1494	75	carotene	carotene	NN
cord-023168-cd7adns8	1494	76	on	on	IN
cord-023168-cd7adns8	1494	77	mortality	mortality	NN
cord-023168-cd7adns8	1494	78	related	relate	VBN
cord-023168-cd7adns8	1494	79	to	to	IN
cord-023168-cd7adns8	1494	80	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1494	81	in	in	IN
cord-023168-cd7adns8	1494	82	Nepal	Nepal	NNP
cord-023168-cd7adns8	1494	83	.	.	.
cord-023168-cd7adns8	1495	1	The	the	DT
cord-023168-cd7adns8	1495	2	NNIPS	NNIPS	NNP
cord-023168-cd7adns8	1495	3	-	-	HYPH
cord-023168-cd7adns8	1495	4	Study	Study	NNP
cord-023168-cd7adns8	1495	5	Group	Group	NNP
cord-023168-cd7adns8	1495	6	Randomised	randomised	JJ
cord-023168-cd7adns8	1495	7	trial	trial	NN
cord-023168-cd7adns8	1495	8	of	of	IN
cord-023168-cd7adns8	1495	9	effects	effect	NNS
cord-023168-cd7adns8	1495	10	of	of	IN
cord-023168-cd7adns8	1495	11	vitamin	vitamin	NN
cord-023168-cd7adns8	1495	12	supplements	supplement	NNS
cord-023168-cd7adns8	1495	13	on	on	IN
cord-023168-cd7adns8	1495	14	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1495	15	outcomes	outcome	NNS
cord-023168-cd7adns8	1495	16	and	and	CC
cord-023168-cd7adns8	1495	17	T	t	NN
cord-023168-cd7adns8	1495	18	cell	cell	NN
cord-023168-cd7adns8	1495	19	counts	count	VBZ
cord-023168-cd7adns8	1495	20	in	in	IN
cord-023168-cd7adns8	1495	21	HIV-1-infected	hiv-1-infecte	VBN
cord-023168-cd7adns8	1495	22	women	woman	NNS
cord-023168-cd7adns8	1495	23	in	in	IN
cord-023168-cd7adns8	1495	24	Tanzania	Tanzania	NNP
cord-023168-cd7adns8	1496	1	Hematologic	Hematologic	NNP
cord-023168-cd7adns8	1496	2	manifestations	manifestation	NNS
cord-023168-cd7adns8	1496	3	of	of	IN
cord-023168-cd7adns8	1496	4	copper	copper	NN
cord-023168-cd7adns8	1496	5	deficiency	deficiency	NN
cord-023168-cd7adns8	1496	6	:	:	:
cord-023168-cd7adns8	1496	7	a	a	DT
cord-023168-cd7adns8	1496	8	retrospective	retrospective	JJ
cord-023168-cd7adns8	1496	9	review	review	NN
cord-023168-cd7adns8	1496	10	Update	update	NN
cord-023168-cd7adns8	1496	11	on	on	IN
cord-023168-cd7adns8	1496	12	anemia	anemia	NN
cord-023168-cd7adns8	1496	13	and	and	CC
cord-023168-cd7adns8	1496	14	neutropenia	neutropenia	NN
cord-023168-cd7adns8	1496	15	in	in	IN
cord-023168-cd7adns8	1496	16	copper	copper	NN
cord-023168-cd7adns8	1496	17	deficiency	deficiency	NN
cord-023168-cd7adns8	1496	18	Zinc	Zinc	NNP
cord-023168-cd7adns8	1496	19	deficiency	deficiency	NN
cord-023168-cd7adns8	1496	20	in	in	IN
cord-023168-cd7adns8	1496	21	patients	patient	NNS
cord-023168-cd7adns8	1496	22	with	with	IN
cord-023168-cd7adns8	1496	23	sickle	sickle	NN
cord-023168-cd7adns8	1496	24	cell	cell	NN
cord-023168-cd7adns8	1496	25	disease	disease	NN
cord-023168-cd7adns8	1496	26	Effect	Effect	NNP
cord-023168-cd7adns8	1496	27	of	of	IN
cord-023168-cd7adns8	1496	28	zinc	zinc	NN
cord-023168-cd7adns8	1496	29	supplementation	supplementation	NN
cord-023168-cd7adns8	1496	30	on	on	IN
cord-023168-cd7adns8	1496	31	incidence	incidence	NN
cord-023168-cd7adns8	1496	32	of	of	IN
cord-023168-cd7adns8	1496	33	infections	infection	NNS
cord-023168-cd7adns8	1496	34	and	and	CC
cord-023168-cd7adns8	1496	35	hospital	hospital	NN
cord-023168-cd7adns8	1496	36	admissions	admission	NNS
cord-023168-cd7adns8	1496	37	in	in	IN
cord-023168-cd7adns8	1496	38	sickle	sickle	NN
cord-023168-cd7adns8	1496	39	cell	cell	NN
cord-023168-cd7adns8	1496	40	disease	disease	NN
cord-023168-cd7adns8	1496	41	(	(	-LRB-
cord-023168-cd7adns8	1496	42	SCD	SCD	NNP
cord-023168-cd7adns8	1496	43	)	)	-RRB-
cord-023168-cd7adns8	1496	44	Human	human	JJ
cord-023168-cd7adns8	1496	45	schistosomiasis	schistosomiasis	NN
cord-023168-cd7adns8	1496	46	and	and	CC
cord-023168-cd7adns8	1496	47	anemia	anemia	NN
cord-023168-cd7adns8	1496	48	:	:	:
cord-023168-cd7adns8	1497	1	The	the	DT
cord-023168-cd7adns8	1497	2	relationship	relationship	NN
cord-023168-cd7adns8	1497	3	and	and	CC
cord-023168-cd7adns8	1497	4	potential	potential	JJ
cord-023168-cd7adns8	1497	5	mechanisms	mechanism	NNS
cord-023168-cd7adns8	1497	6	Hemoquant	Hemoquant	NNP
cord-023168-cd7adns8	1497	7	determination	determination	NN
cord-023168-cd7adns8	1497	8	of	of	IN
cord-023168-cd7adns8	1497	9	hookwormrelated	hookwormrelated	JJ
cord-023168-cd7adns8	1497	10	blood	blood	NN
cord-023168-cd7adns8	1497	11	loss	loss	NN
cord-023168-cd7adns8	1497	12	and	and	CC
cord-023168-cd7adns8	1497	13	its	-PRON-	PRP$
cord-023168-cd7adns8	1497	14	role	role	NN
cord-023168-cd7adns8	1497	15	in	in	IN
cord-023168-cd7adns8	1497	16	iron	iron	NN
cord-023168-cd7adns8	1497	17	deficiency	deficiency	NN
cord-023168-cd7adns8	1497	18	in	in	IN
cord-023168-cd7adns8	1497	19	African	african	JJ
cord-023168-cd7adns8	1497	20	children	child	NNS
cord-023168-cd7adns8	1497	21	Functional	functional	JJ
cord-023168-cd7adns8	1497	22	significance	significance	NN
cord-023168-cd7adns8	1497	23	of	of	IN
cord-023168-cd7adns8	1497	24	low	low	JJ
cord-023168-cd7adns8	1497	25	-	-	HYPH
cord-023168-cd7adns8	1497	26	intensity	intensity	NN
cord-023168-cd7adns8	1497	27	polyparasitehelminth	polyparasitehelminth	JJ
cord-023168-cd7adns8	1497	28	infections	infection	NNS
cord-023168-cd7adns8	1497	29	in	in	IN
cord-023168-cd7adns8	1497	30	anemia	anemia	NN
cord-023168-cd7adns8	1497	31	Impact	Impact	NNP
cord-023168-cd7adns8	1497	32	of	of	IN
cord-023168-cd7adns8	1497	33	mass	mass	JJ
cord-023168-cd7adns8	1497	34	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1497	35	on	on	IN
cord-023168-cd7adns8	1497	36	the	the	DT
cord-023168-cd7adns8	1497	37	morbidity	morbidity	NN
cord-023168-cd7adns8	1497	38	due	due	IN
cord-023168-cd7adns8	1497	39	to	to	IN
cord-023168-cd7adns8	1497	40	soil	soil	NN
cord-023168-cd7adns8	1497	41	-	-	HYPH
cord-023168-cd7adns8	1497	42	transmitted	transmit	VBN
cord-023168-cd7adns8	1497	43	nematodes	nematode	NNS
cord-023168-cd7adns8	1497	44	Haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1497	45	concentrations	concentration	NNS
cord-023168-cd7adns8	1497	46	and	and	CC
cord-023168-cd7adns8	1497	47	concomitant	concomitant	JJ
cord-023168-cd7adns8	1497	48	infections	infection	NNS
cord-023168-cd7adns8	1497	49	of	of	IN
cord-023168-cd7adns8	1497	50	hookworm	hookworm	NN
cord-023168-cd7adns8	1497	51	and	and	CC
cord-023168-cd7adns8	1497	52	Trichuris	Trichuris	NNP
cord-023168-cd7adns8	1497	53	trichiura	trichiura	NN
cord-023168-cd7adns8	1497	54	in	in	IN
cord-023168-cd7adns8	1497	55	Panamanian	panamanian	JJ
cord-023168-cd7adns8	1497	56	primary	primary	JJ
cord-023168-cd7adns8	1497	57	schoolchildren	schoolchildren	NNS
cord-023168-cd7adns8	1498	1	Anthelmintic	anthelmintic	JJ
cord-023168-cd7adns8	1498	2	treatment	treatment	NN
cord-023168-cd7adns8	1498	3	improves	improve	VBZ
cord-023168-cd7adns8	1498	4	the	the	DT
cord-023168-cd7adns8	1498	5	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1498	6	and	and	CC
cord-023168-cd7adns8	1498	7	serum	serum	NN
cord-023168-cd7adns8	1498	8	ferritin	ferritin	NN
cord-023168-cd7adns8	1498	9	concentrations	concentration	NNS
cord-023168-cd7adns8	1498	10	of	of	IN
cord-023168-cd7adns8	1498	11	Tanzanian	tanzanian	JJ
cord-023168-cd7adns8	1498	12	schoolchildren	schoolchildren	NNS
cord-023168-cd7adns8	1498	13	Impact	Impact	NNP
cord-023168-cd7adns8	1498	14	of	of	IN
cord-023168-cd7adns8	1498	15	a	a	DT
cord-023168-cd7adns8	1498	16	national	national	JJ
cord-023168-cd7adns8	1498	17	helminth	helminth	NNP
cord-023168-cd7adns8	1498	18	control	control	NN
cord-023168-cd7adns8	1498	19	programme	programme	NN
cord-023168-cd7adns8	1498	20	on	on	IN
cord-023168-cd7adns8	1498	21	infection	infection	NN
cord-023168-cd7adns8	1498	22	and	and	CC
cord-023168-cd7adns8	1498	23	morbidity	morbidity	NN
cord-023168-cd7adns8	1498	24	in	in	IN
cord-023168-cd7adns8	1498	25	Ugandan	ugandan	JJ
cord-023168-cd7adns8	1498	26	schoolchildren	schoolchildren	NNS
cord-023168-cd7adns8	1498	27	Anthelmintic	Anthelmintic	NNP
cord-023168-cd7adns8	1498	28	treatment	treatment	NN
cord-023168-cd7adns8	1498	29	and	and	CC
cord-023168-cd7adns8	1498	30	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1498	31	concentrations	concentration	NNS
cord-023168-cd7adns8	1498	32	during	during	IN
cord-023168-cd7adns8	1498	33	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1498	34	Low	Low	NNP
cord-023168-cd7adns8	1498	35	dose	dose	NN
cord-023168-cd7adns8	1498	36	daily	daily	JJ
cord-023168-cd7adns8	1498	37	iron	iron	NN
cord-023168-cd7adns8	1498	38	supplementation	supplementation	NN
cord-023168-cd7adns8	1498	39	improves	improve	VBZ
cord-023168-cd7adns8	1498	40	iron	iron	NN
cord-023168-cd7adns8	1498	41	status	status	NN
cord-023168-cd7adns8	1498	42	and	and	CC
cord-023168-cd7adns8	1498	43	appetite	appetite	NN
cord-023168-cd7adns8	1498	44	but	but	CC
cord-023168-cd7adns8	1498	45	not	not	RB
cord-023168-cd7adns8	1498	46	anemia	anemia	NN
cord-023168-cd7adns8	1498	47	,	,	,
cord-023168-cd7adns8	1498	48	whereas	whereas	IN
cord-023168-cd7adns8	1498	49	quarterly	quarterly	JJ
cord-023168-cd7adns8	1498	50	anthelmintic	anthelmintic	JJ
cord-023168-cd7adns8	1498	51	treatment	treatment	NN
cord-023168-cd7adns8	1498	52	improves	improve	VBZ
cord-023168-cd7adns8	1498	53	growth	growth	NN
cord-023168-cd7adns8	1498	54	,	,	,
cord-023168-cd7adns8	1498	55	appetite	appetite	NN
cord-023168-cd7adns8	1498	56	and	and	CC
cord-023168-cd7adns8	1498	57	anemia	anemia	NN
cord-023168-cd7adns8	1498	58	in	in	IN
cord-023168-cd7adns8	1498	59	Zanzibari	Zanzibari	NNP
cord-023168-cd7adns8	1498	60	preschool	preschool	NN
cord-023168-cd7adns8	1498	61	children	child	NNS
cord-023168-cd7adns8	1498	62	Epidemiology	Epidemiology	NNP
cord-023168-cd7adns8	1498	63	of	of	IN
cord-023168-cd7adns8	1498	64	iron	iron	NN
cord-023168-cd7adns8	1498	65	deficiency	deficiency	NN
cord-023168-cd7adns8	1498	66	anemia	anemia	NN
cord-023168-cd7adns8	1498	67	in	in	IN
cord-023168-cd7adns8	1498	68	Zanzibari	Zanzibari	NNP
cord-023168-cd7adns8	1498	69	schoolchildren	schoolchildren	NNS
cord-023168-cd7adns8	1498	70	:	:	:
cord-023168-cd7adns8	1499	1	The	the	DT
cord-023168-cd7adns8	1499	2	importance	importance	NN
cord-023168-cd7adns8	1499	3	of	of	IN
cord-023168-cd7adns8	1499	4	hookworms	hookworm	NNS
cord-023168-cd7adns8	1499	5	Sickle	Sickle	NNP
cord-023168-cd7adns8	1499	6	cell	cell	NN
cord-023168-cd7adns8	1499	7	disease	disease	NN
cord-023168-cd7adns8	1499	8	Management	Management	NNP
cord-023168-cd7adns8	1499	9	of	of	IN
cord-023168-cd7adns8	1499	10	sickle	sickle	NN
cord-023168-cd7adns8	1499	11	cell	cell	NN
cord-023168-cd7adns8	1499	12	disease	disease	NNP
cord-023168-cd7adns8	1499	13	Sickle	Sickle	NNP
cord-023168-cd7adns8	1499	14	cell	cell	NN
cord-023168-cd7adns8	1499	15	disease	disease	NN
cord-023168-cd7adns8	1499	16	Peculiar	Peculiar	NNP
cord-023168-cd7adns8	1499	17	elongated	elongated	JJ
cord-023168-cd7adns8	1499	18	and	and	CC
cord-023168-cd7adns8	1499	19	sickleshaped	sickleshaped	JJ
cord-023168-cd7adns8	1499	20	red	red	JJ
cord-023168-cd7adns8	1499	21	blood	blood	NN
cord-023168-cd7adns8	1499	22	corpuscles	corpuscle	NNS
cord-023168-cd7adns8	1499	23	in	in	IN
cord-023168-cd7adns8	1499	24	a	a	DT
cord-023168-cd7adns8	1499	25	case	case	NN
cord-023168-cd7adns8	1499	26	of	of	IN
cord-023168-cd7adns8	1499	27	severe	severe	JJ
cord-023168-cd7adns8	1499	28	anemia	anemia	NN
cord-023168-cd7adns8	1499	29	Sickle	Sickle	NNP
cord-023168-cd7adns8	1499	30	cell	cell	NN
cord-023168-cd7adns8	1499	31	anemia	anemia	NN
cord-023168-cd7adns8	1499	32	and	and	CC
cord-023168-cd7adns8	1499	33	related	related	JJ
cord-023168-cd7adns8	1499	34	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1499	35	Sickle	Sickle	NNP
cord-023168-cd7adns8	1499	36	cell	cell	NN
cord-023168-cd7adns8	1499	37	anemia	anemia	NN
cord-023168-cd7adns8	1499	38	,	,	,
cord-023168-cd7adns8	1499	39	a	a	DT
cord-023168-cd7adns8	1499	40	molecular	molecular	JJ
cord-023168-cd7adns8	1499	41	disease	disease	NN
cord-023168-cd7adns8	1499	42	Hemoglobin	Hemoglobin	NNP
cord-023168-cd7adns8	1499	43	S	S	NNP
cord-023168-cd7adns8	1499	44	polymerization	polymerization	NN
cord-023168-cd7adns8	1499	45	:	:	:
cord-023168-cd7adns8	1499	46	primary	primary	JJ
cord-023168-cd7adns8	1499	47	determinant	determinant	NN
cord-023168-cd7adns8	1499	48	of	of	IN
cord-023168-cd7adns8	1499	49	the	the	DT
cord-023168-cd7adns8	1499	50	hemolytic	hemolytic	JJ
cord-023168-cd7adns8	1499	51	and	and	CC
cord-023168-cd7adns8	1499	52	clinical	clinical	JJ
cord-023168-cd7adns8	1499	53	severity	severity	NN
cord-023168-cd7adns8	1499	54	of	of	IN
cord-023168-cd7adns8	1499	55	the	the	DT
cord-023168-cd7adns8	1499	56	sickling	sickling	NN
cord-023168-cd7adns8	1499	57	syndromes	syndrome	NNS
cord-023168-cd7adns8	1499	58	Hemoglobin	Hemoglobin	NNP
cord-023168-cd7adns8	1499	59	S	S	NNP
cord-023168-cd7adns8	1499	60	gelation	gelation	NN
cord-023168-cd7adns8	1499	61	and	and	CC
cord-023168-cd7adns8	1499	62	sickle	sickle	NN
cord-023168-cd7adns8	1499	63	cell	cell	NN
cord-023168-cd7adns8	1499	64	disease	disease	NN
cord-023168-cd7adns8	1499	65	Pathogenesis	Pathogenesis	NNP
cord-023168-cd7adns8	1499	66	and	and	CC
cord-023168-cd7adns8	1499	67	treatment	treatment	NN
cord-023168-cd7adns8	1499	68	of	of	IN
cord-023168-cd7adns8	1499	69	sickle	sickle	NN
cord-023168-cd7adns8	1499	70	cell	cell	NN
cord-023168-cd7adns8	1499	71	disease	disease	NNP
cord-023168-cd7adns8	1499	72	Polymer	Polymer	NNP
cord-023168-cd7adns8	1499	73	structure	structure	NN
cord-023168-cd7adns8	1499	74	and	and	CC
cord-023168-cd7adns8	1499	75	polymerization	polymerization	NN
cord-023168-cd7adns8	1499	76	of	of	IN
cord-023168-cd7adns8	1499	77	deoxyhemoglobin	deoxyhemoglobin	NNP
cord-023168-cd7adns8	1499	78	Sickle	Sickle	NNP
cord-023168-cd7adns8	1499	79	cell	cell	NN
cord-023168-cd7adns8	1499	80	anemia	anemia	NN
cord-023168-cd7adns8	1499	81	and	and	CC
cord-023168-cd7adns8	1499	82	other	other	JJ
cord-023168-cd7adns8	1499	83	sickling	sickling	NN
cord-023168-cd7adns8	1499	84	syndromes	syndrome	NNS
cord-023168-cd7adns8	1500	1	Levels	level	NNS
cord-023168-cd7adns8	1500	2	of	of	IN
cord-023168-cd7adns8	1500	3	fetal	fetal	JJ
cord-023168-cd7adns8	1500	4	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1500	5	necessary	necessary	JJ
cord-023168-cd7adns8	1500	6	for	for	IN
cord-023168-cd7adns8	1500	7	treatment	treatment	NN
cord-023168-cd7adns8	1500	8	of	of	IN
cord-023168-cd7adns8	1500	9	sickle	sickle	NN
cord-023168-cd7adns8	1500	10	cell	cell	NN
cord-023168-cd7adns8	1500	11	disease	disease	NNP
cord-023168-cd7adns8	1500	12	Sickle	Sickle	NNP
cord-023168-cd7adns8	1500	13	cell	cell	NN
cord-023168-cd7adns8	1500	14	vaso	vaso	NNP
cord-023168-cd7adns8	1500	15	-	-	HYPH
cord-023168-cd7adns8	1500	16	occlusion	occlusion	NN
cord-023168-cd7adns8	1500	17	:	:	:
cord-023168-cd7adns8	1500	18	multistep	multistep	JJ
cord-023168-cd7adns8	1500	19	and	and	CC
cord-023168-cd7adns8	1500	20	multicellular	multicellular	JJ
cord-023168-cd7adns8	1500	21	paradigm	paradigm	NN
cord-023168-cd7adns8	1500	22	Blockade	blockade	NN
cord-023168-cd7adns8	1500	23	of	of	IN
cord-023168-cd7adns8	1500	24	adhesion	adhesion	NN
cord-023168-cd7adns8	1500	25	of	of	IN
cord-023168-cd7adns8	1500	26	sickle	sickle	NN
cord-023168-cd7adns8	1500	27	cells	cell	NNS
cord-023168-cd7adns8	1500	28	to	to	IN
cord-023168-cd7adns8	1500	29	endothelium	endothelium	NN
cord-023168-cd7adns8	1500	30	by	by	IN
cord-023168-cd7adns8	1500	31	monoclonal	monoclonal	JJ
cord-023168-cd7adns8	1500	32	antibodies	antibody	NNS
cord-023168-cd7adns8	1500	33	Thrombospondin	Thrombospondin	NNP
cord-023168-cd7adns8	1500	34	from	from	IN
cord-023168-cd7adns8	1500	35	activated	activate	VBN
cord-023168-cd7adns8	1500	36	platelets	platelet	NNS
cord-023168-cd7adns8	1500	37	promotes	promote	VBZ
cord-023168-cd7adns8	1500	38	sickle	sickle	NN
cord-023168-cd7adns8	1500	39	erythrocyte	erythrocyte	NN
cord-023168-cd7adns8	1500	40	adherence	adherence	NN
cord-023168-cd7adns8	1500	41	to	to	IN
cord-023168-cd7adns8	1500	42	human	human	JJ
cord-023168-cd7adns8	1500	43	microvascular	microvascular	JJ
cord-023168-cd7adns8	1500	44	endothelium	endothelium	NN
cord-023168-cd7adns8	1500	45	under	under	IN
cord-023168-cd7adns8	1500	46	physiologic	physiologic	JJ
cord-023168-cd7adns8	1500	47	flow	flow	NN
cord-023168-cd7adns8	1500	48	:	:	:
cord-023168-cd7adns8	1500	49	a	a	DT
cord-023168-cd7adns8	1500	50	potential	potential	JJ
cord-023168-cd7adns8	1500	51	role	role	NN
cord-023168-cd7adns8	1500	52	for	for	IN
cord-023168-cd7adns8	1500	53	platelet	platelet	NN
cord-023168-cd7adns8	1500	54	activation	activation	NN
cord-023168-cd7adns8	1500	55	in	in	IN
cord-023168-cd7adns8	1500	56	sickle	sickle	NN
cord-023168-cd7adns8	1500	57	cell	cell	NN
cord-023168-cd7adns8	1500	58	vaso	vaso	NNP
cord-023168-cd7adns8	1500	59	-	-	HYPH
cord-023168-cd7adns8	1500	60	occlusion	occlusion	NNP
cord-023168-cd7adns8	1500	61	Sickle	Sickle	NNP
cord-023168-cd7adns8	1500	62	erythrocyte	erythrocyte	NN
cord-023168-cd7adns8	1500	63	-	-	HYPH
cord-023168-cd7adns8	1500	64	endothelial	endothelial	JJ
cord-023168-cd7adns8	1500	65	interactions	interaction	NNS
cord-023168-cd7adns8	1500	66	in	in	IN
cord-023168-cd7adns8	1500	67	microcirculation	microcirculation	NN
cord-023168-cd7adns8	1500	68	:	:	:
cord-023168-cd7adns8	1500	69	the	the	DT
cord-023168-cd7adns8	1500	70	role	role	NN
cord-023168-cd7adns8	1500	71	of	of	IN
cord-023168-cd7adns8	1500	72	von	von	NNP
cord-023168-cd7adns8	1500	73	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1500	74	factor	factor	NN
cord-023168-cd7adns8	1500	75	and	and	CC
cord-023168-cd7adns8	1500	76	implications	implication	NNS
cord-023168-cd7adns8	1500	77	for	for	IN
cord-023168-cd7adns8	1500	78	vaso	vaso	NN
cord-023168-cd7adns8	1500	79	-	-	HYPH
cord-023168-cd7adns8	1500	80	occlusion	occlusion	NNP
cord-023168-cd7adns8	1501	1	The	the	DT
cord-023168-cd7adns8	1501	2	clinical	clinical	JJ
cord-023168-cd7adns8	1501	3	sequelae	sequela	NNS
cord-023168-cd7adns8	1501	4	of	of	IN
cord-023168-cd7adns8	1501	5	intravascular	intravascular	JJ
cord-023168-cd7adns8	1501	6	hemolysis	hemolysis	NN
cord-023168-cd7adns8	1501	7	and	and	CC
cord-023168-cd7adns8	1501	8	extracellular	extracellular	JJ
cord-023168-cd7adns8	1501	9	plasma	plasma	NN
cord-023168-cd7adns8	1501	10	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1501	11	:	:	:
cord-023168-cd7adns8	1502	1	a	a	DT
cord-023168-cd7adns8	1502	2	novel	novel	JJ
cord-023168-cd7adns8	1502	3	mechanism	mechanism	NN
cord-023168-cd7adns8	1502	4	of	of	IN
cord-023168-cd7adns8	1502	5	human	human	JJ
cord-023168-cd7adns8	1502	6	disease	disease	NN
cord-023168-cd7adns8	1502	7	Nitric	nitric	NN
cord-023168-cd7adns8	1502	8	oxide	oxide	NN
cord-023168-cd7adns8	1502	9	decreases	decrease	VBZ
cord-023168-cd7adns8	1502	10	cytokine	cytokine	NN
cord-023168-cd7adns8	1502	11	-	-	HYPH
cord-023168-cd7adns8	1502	12	induced	induce	VBN
cord-023168-cd7adns8	1502	13	endothelial	endothelial	JJ
cord-023168-cd7adns8	1502	14	activation	activation	NN
cord-023168-cd7adns8	1502	15	.	.	.
cord-023168-cd7adns8	1503	1	Nitric	nitric	NN
cord-023168-cd7adns8	1503	2	oxide	oxide	NN
cord-023168-cd7adns8	1503	3	selectively	selectively	RB
cord-023168-cd7adns8	1503	4	reduces	reduce	VBZ
cord-023168-cd7adns8	1503	5	endothelial	endothelial	JJ
cord-023168-cd7adns8	1503	6	expression	expression	NN
cord-023168-cd7adns8	1503	7	of	of	IN
cord-023168-cd7adns8	1503	8	adhesion	adhesion	NN
cord-023168-cd7adns8	1503	9	molecules	molecule	NNS
cord-023168-cd7adns8	1503	10	and	and	CC
cord-023168-cd7adns8	1503	11	pro	pro	JJ
cord-023168-cd7adns8	1503	12	-	-	JJ
cord-023168-cd7adns8	1503	13	inflammatory	inflammatory	JJ
cord-023168-cd7adns8	1503	14	cytokines	cytokine	NNS
cord-023168-cd7adns8	1503	15	Coagulation	coagulation	NN
cord-023168-cd7adns8	1503	16	activation	activation	NN
cord-023168-cd7adns8	1503	17	and	and	CC
cord-023168-cd7adns8	1503	18	inflammation	inflammation	NN
cord-023168-cd7adns8	1503	19	in	in	IN
cord-023168-cd7adns8	1503	20	sickle	sickle	NN
cord-023168-cd7adns8	1503	21	cell	cell	NN
cord-023168-cd7adns8	1503	22	disease	disease	NN
cord-023168-cd7adns8	1503	23	-	-	HYPH
cord-023168-cd7adns8	1503	24	associated	associate	VBN
cord-023168-cd7adns8	1503	25	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	1503	26	hypertension	hypertension	NN
cord-023168-cd7adns8	1504	1	The	the	DT
cord-023168-cd7adns8	1504	2	crisis	crisis	NN
cord-023168-cd7adns8	1504	3	in	in	IN
cord-023168-cd7adns8	1504	4	sickle	sickle	NN
cord-023168-cd7adns8	1504	5	cell	cell	NN
cord-023168-cd7adns8	1504	6	anemia	anemia	NN
cord-023168-cd7adns8	1504	7	;	;	:
cord-023168-cd7adns8	1504	8	hematologic	hematologic	JJ
cord-023168-cd7adns8	1504	9	studies	study	NNS
cord-023168-cd7adns8	1504	10	Sickle	sickle	NN
cord-023168-cd7adns8	1504	11	-	-	HYPH
cord-023168-cd7adns8	1504	12	cell	cell	NN
cord-023168-cd7adns8	1504	13	pain	pain	NN
cord-023168-cd7adns8	1504	14	:	:	:
cord-023168-cd7adns8	1504	15	advances	advance	NNS
cord-023168-cd7adns8	1504	16	in	in	IN
cord-023168-cd7adns8	1504	17	epidemiology	epidemiology	NN
cord-023168-cd7adns8	1504	18	and	and	CC
cord-023168-cd7adns8	1504	19	etiology	etiology	NN
cord-023168-cd7adns8	1504	20	Pain	pain	NN
cord-023168-cd7adns8	1504	21	in	in	IN
cord-023168-cd7adns8	1504	22	sickle	sickle	NN
cord-023168-cd7adns8	1504	23	cell	cell	NN
cord-023168-cd7adns8	1504	24	disease	disease	NN
cord-023168-cd7adns8	1504	25	.	.	.
cord-023168-cd7adns8	1505	1	Rates	rate	NNS
cord-023168-cd7adns8	1505	2	and	and	CC
cord-023168-cd7adns8	1505	3	risk	risk	NN
cord-023168-cd7adns8	1505	4	factors	factor	NNS
cord-023168-cd7adns8	1505	5	Guidelines	guideline	NNS
cord-023168-cd7adns8	1505	6	for	for	IN
cord-023168-cd7adns8	1505	7	the	the	DT
cord-023168-cd7adns8	1505	8	management	management	NN
cord-023168-cd7adns8	1505	9	of	of	IN
cord-023168-cd7adns8	1505	10	the	the	DT
cord-023168-cd7adns8	1505	11	acute	acute	JJ
cord-023168-cd7adns8	1505	12	painful	painful	JJ
cord-023168-cd7adns8	1505	13	crisis	crisis	NN
cord-023168-cd7adns8	1505	14	in	in	IN
cord-023168-cd7adns8	1505	15	sickle	sickle	NN
cord-023168-cd7adns8	1505	16	cell	cell	NN
cord-023168-cd7adns8	1505	17	disease	disease	NN
cord-023168-cd7adns8	1505	18	Pulmonary	pulmonary	JJ
cord-023168-cd7adns8	1505	19	hypertension	hypertension	NN
cord-023168-cd7adns8	1505	20	as	as	IN
cord-023168-cd7adns8	1505	21	a	a	DT
cord-023168-cd7adns8	1505	22	risk	risk	NN
cord-023168-cd7adns8	1505	23	factor	factor	NN
cord-023168-cd7adns8	1505	24	for	for	IN
cord-023168-cd7adns8	1505	25	death	death	NN
cord-023168-cd7adns8	1505	26	in	in	IN
cord-023168-cd7adns8	1505	27	patients	patient	NNS
cord-023168-cd7adns8	1505	28	with	with	IN
cord-023168-cd7adns8	1505	29	sickle	sickle	NN
cord-023168-cd7adns8	1505	30	cell	cell	NN
cord-023168-cd7adns8	1505	31	disease	disease	NN
cord-023168-cd7adns8	1505	32	Deconstructing	deconstruct	VBG
cord-023168-cd7adns8	1505	33	sickle	sickle	NN
cord-023168-cd7adns8	1505	34	cell	cell	NN
cord-023168-cd7adns8	1505	35	disease	disease	NN
cord-023168-cd7adns8	1505	36	:	:	:
cord-023168-cd7adns8	1505	37	reappraisal	reappraisal	NN
cord-023168-cd7adns8	1505	38	of	of	IN
cord-023168-cd7adns8	1505	39	the	the	DT
cord-023168-cd7adns8	1505	40	role	role	NN
cord-023168-cd7adns8	1505	41	of	of	IN
cord-023168-cd7adns8	1505	42	hemolysis	hemolysis	NN
cord-023168-cd7adns8	1505	43	in	in	IN
cord-023168-cd7adns8	1505	44	the	the	DT
cord-023168-cd7adns8	1505	45	development	development	NN
cord-023168-cd7adns8	1505	46	of	of	IN
cord-023168-cd7adns8	1505	47	clinical	clinical	JJ
cord-023168-cd7adns8	1505	48	sub	sub	JJ
cord-023168-cd7adns8	1505	49	-	-	JJ
cord-023168-cd7adns8	1505	50	phenotypes	phenotypes	JJ
cord-023168-cd7adns8	1505	51	Functional	functional	JJ
cord-023168-cd7adns8	1505	52	asplenia	asplenia	NN
cord-023168-cd7adns8	1505	53	in	in	IN
cord-023168-cd7adns8	1505	54	sickle	sickle	NN
cord-023168-cd7adns8	1505	55	-	-	HYPH
cord-023168-cd7adns8	1505	56	cell	cell	NN
cord-023168-cd7adns8	1505	57	anemia	anemia	NN
cord-023168-cd7adns8	1505	58	Acute	acute	JJ
cord-023168-cd7adns8	1505	59	chest	chest	NN
cord-023168-cd7adns8	1505	60	syndrome	syndrome	NN
cord-023168-cd7adns8	1505	61	:	:	:
cord-023168-cd7adns8	1505	62	sickle	sickle	NN
cord-023168-cd7adns8	1505	63	cell	cell	NN
cord-023168-cd7adns8	1505	64	disease	disease	NN
cord-023168-cd7adns8	1505	65	Acute	Acute	NNP
cord-023168-cd7adns8	1505	66	chest	chest	NN
cord-023168-cd7adns8	1505	67	syndrome	syndrome	NN
cord-023168-cd7adns8	1505	68	in	in	IN
cord-023168-cd7adns8	1505	69	sickle	sickle	NN
cord-023168-cd7adns8	1505	70	cell	cell	NN
cord-023168-cd7adns8	1505	71	disease	disease	NN
cord-023168-cd7adns8	1505	72	:	:	:
cord-023168-cd7adns8	1505	73	Clinical	clinical	JJ
cord-023168-cd7adns8	1505	74	presentation	presentation	NN
cord-023168-cd7adns8	1505	75	and	and	CC
cord-023168-cd7adns8	1505	76	course	course	NN
cord-023168-cd7adns8	1505	77	.	.	.
cord-023168-cd7adns8	1506	1	Cooperative	Cooperative	NNP
cord-023168-cd7adns8	1506	2	Study	Study	NNP
cord-023168-cd7adns8	1506	3	of	of	IN
cord-023168-cd7adns8	1506	4	Sickle	Sickle	NNP
cord-023168-cd7adns8	1506	5	Cell	Cell	NNP
cord-023168-cd7adns8	1506	6	Disease	Disease	NNP
cord-023168-cd7adns8	1506	7	National	National	NNP
cord-023168-cd7adns8	1506	8	Acute	Acute	NNP
cord-023168-cd7adns8	1506	9	Chest	Chest	NNP
cord-023168-cd7adns8	1506	10	Syndrome	Syndrome	NNP
cord-023168-cd7adns8	1506	11	Study	Study	NNP
cord-023168-cd7adns8	1506	12	Group	Group	NNP
cord-023168-cd7adns8	1506	13	.	.	.
cord-023168-cd7adns8	1507	1	Causes	cause	NNS
cord-023168-cd7adns8	1507	2	and	and	CC
cord-023168-cd7adns8	1507	3	outcomes	outcome	NNS
cord-023168-cd7adns8	1507	4	of	of	IN
cord-023168-cd7adns8	1507	5	the	the	DT
cord-023168-cd7adns8	1507	6	acute	acute	JJ
cord-023168-cd7adns8	1507	7	chest	chest	NN
cord-023168-cd7adns8	1507	8	syndrome	syndrome	NN
cord-023168-cd7adns8	1507	9	in	in	IN
cord-023168-cd7adns8	1507	10	sickle	sickle	NN
cord-023168-cd7adns8	1507	11	cell	cell	NN
cord-023168-cd7adns8	1507	12	disease	disease	NN
cord-023168-cd7adns8	1508	1	The	the	DT
cord-023168-cd7adns8	1508	2	acute	acute	JJ
cord-023168-cd7adns8	1508	3	chest	chest	NN
cord-023168-cd7adns8	1508	4	syndrome	syndrome	NN
cord-023168-cd7adns8	1508	5	in	in	IN
cord-023168-cd7adns8	1508	6	sickle	sickle	NN
cord-023168-cd7adns8	1508	7	cell	cell	NN
cord-023168-cd7adns8	1508	8	disease	disease	NN
cord-023168-cd7adns8	1508	9	:	:	:
cord-023168-cd7adns8	1508	10	incidence	incidence	NN
cord-023168-cd7adns8	1508	11	and	and	CC
cord-023168-cd7adns8	1508	12	risk	risk	NN
cord-023168-cd7adns8	1508	13	factors	factor	NNS
cord-023168-cd7adns8	1509	1	Acute	acute	JJ
cord-023168-cd7adns8	1509	2	chest	chest	NN
cord-023168-cd7adns8	1509	3	syndrome	syndrome	NN
cord-023168-cd7adns8	1509	4	in	in	IN
cord-023168-cd7adns8	1509	5	sickle	sickle	NN
cord-023168-cd7adns8	1509	6	-	-	HYPH
cord-023168-cd7adns8	1509	7	cell	cell	NN
cord-023168-cd7adns8	1509	8	disease	disease	NN
cord-023168-cd7adns8	1509	9	Bronchoalveolar	Bronchoalveolar	NNP
cord-023168-cd7adns8	1509	10	lavage	lavage	NN
cord-023168-cd7adns8	1509	11	in	in	IN
cord-023168-cd7adns8	1509	12	adult	adult	NN
cord-023168-cd7adns8	1509	13	sickle	sickle	NN
cord-023168-cd7adns8	1509	14	cell	cell	NN
cord-023168-cd7adns8	1509	15	patients	patient	NNS
cord-023168-cd7adns8	1509	16	with	with	IN
cord-023168-cd7adns8	1509	17	acute	acute	JJ
cord-023168-cd7adns8	1509	18	chest	chest	NN
cord-023168-cd7adns8	1509	19	syndrome	syndrome	NN
cord-023168-cd7adns8	1509	20	:	:	:
cord-023168-cd7adns8	1509	21	value	value	NN
cord-023168-cd7adns8	1509	22	for	for	IN
cord-023168-cd7adns8	1509	23	diagnostic	diagnostic	JJ
cord-023168-cd7adns8	1509	24	assessment	assessment	NN
cord-023168-cd7adns8	1509	25	of	of	IN
cord-023168-cd7adns8	1509	26	fat	fat	JJ
cord-023168-cd7adns8	1509	27	embolism	embolism	NN
cord-023168-cd7adns8	1509	28	Secretory	secretory	JJ
cord-023168-cd7adns8	1509	29	phospholipase	phospholipase	NN
cord-023168-cd7adns8	1509	30	A(2	A(2	NNP
cord-023168-cd7adns8	1509	31	)	)	-RRB-
cord-023168-cd7adns8	1509	32	predicts	predict	VBZ
cord-023168-cd7adns8	1509	33	impending	impend	VBG
cord-023168-cd7adns8	1509	34	acute	acute	JJ
cord-023168-cd7adns8	1509	35	chest	chest	NN
cord-023168-cd7adns8	1509	36	syndrome	syndrome	NN
cord-023168-cd7adns8	1509	37	in	in	IN
cord-023168-cd7adns8	1509	38	sickle	sickle	NN
cord-023168-cd7adns8	1509	39	cell	cell	NN
cord-023168-cd7adns8	1509	40	disease	disease	NN
cord-023168-cd7adns8	1509	41	Serum	Serum	NNP
cord-023168-cd7adns8	1509	42	C	C	NNP
cord-023168-cd7adns8	1509	43	-	-	HYPH
cord-023168-cd7adns8	1509	44	reactive	reactive	JJ
cord-023168-cd7adns8	1509	45	protein	protein	NN
cord-023168-cd7adns8	1509	46	parallels	parallel	VBZ
cord-023168-cd7adns8	1509	47	secretory	secretory	JJ
cord-023168-cd7adns8	1509	48	phospholipase	phospholipase	NNP
cord-023168-cd7adns8	1509	49	A2	A2	NNP
cord-023168-cd7adns8	1509	50	in	in	IN
cord-023168-cd7adns8	1509	51	sickle	sickle	NN
cord-023168-cd7adns8	1509	52	cell	cell	NN
cord-023168-cd7adns8	1509	53	disease	disease	NN
cord-023168-cd7adns8	1509	54	patients	patient	NNS
cord-023168-cd7adns8	1509	55	with	with	IN
cord-023168-cd7adns8	1509	56	vasoocclusive	vasoocclusive	JJ
cord-023168-cd7adns8	1509	57	crisis	crisis	NN
cord-023168-cd7adns8	1509	58	or	or	CC
cord-023168-cd7adns8	1509	59	acute	acute	JJ
cord-023168-cd7adns8	1509	60	chest	chest	NN
cord-023168-cd7adns8	1509	61	syndrome	syndrome	NN
cord-023168-cd7adns8	1509	62	Cerebrovascular	cerebrovascular	JJ
cord-023168-cd7adns8	1509	63	accidents	accident	NNS
cord-023168-cd7adns8	1509	64	in	in	IN
cord-023168-cd7adns8	1509	65	sickle	sickle	NN
cord-023168-cd7adns8	1509	66	cell	cell	NN
cord-023168-cd7adns8	1509	67	disease	disease	NN
cord-023168-cd7adns8	1509	68	:	:	:
cord-023168-cd7adns8	1510	1	rates	rate	NNS
cord-023168-cd7adns8	1510	2	and	and	CC
cord-023168-cd7adns8	1510	3	risk	risk	NN
cord-023168-cd7adns8	1510	4	factors	factor	NNS
cord-023168-cd7adns8	1510	5	Pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	1510	6	and	and	CC
cord-023168-cd7adns8	1510	7	treatment	treatment	NN
cord-023168-cd7adns8	1510	8	of	of	IN
cord-023168-cd7adns8	1510	9	stroke	stroke	NN
cord-023168-cd7adns8	1510	10	in	in	IN
cord-023168-cd7adns8	1510	11	sicklecell	sicklecell	NN
cord-023168-cd7adns8	1510	12	disease	disease	NN
cord-023168-cd7adns8	1510	13	:	:	:
cord-023168-cd7adns8	1510	14	Present	present	JJ
cord-023168-cd7adns8	1510	15	and	and	CC
cord-023168-cd7adns8	1510	16	future	future	JJ
cord-023168-cd7adns8	1510	17	Lesion	lesion	NN
cord-023168-cd7adns8	1510	18	burden	burden	NN
cord-023168-cd7adns8	1510	19	and	and	CC
cord-023168-cd7adns8	1510	20	cognitive	cognitive	JJ
cord-023168-cd7adns8	1510	21	morbidity	morbidity	NN
cord-023168-cd7adns8	1510	22	in	in	IN
cord-023168-cd7adns8	1510	23	children	child	NNS
cord-023168-cd7adns8	1510	24	with	with	IN
cord-023168-cd7adns8	1510	25	sickle	sickle	NN
cord-023168-cd7adns8	1510	26	cell	cell	NN
cord-023168-cd7adns8	1510	27	disease	disease	NNP
cord-023168-cd7adns8	1510	28	Prevention	Prevention	NNP
cord-023168-cd7adns8	1510	29	of	of	IN
cord-023168-cd7adns8	1510	30	a	a	DT
cord-023168-cd7adns8	1510	31	first	first	JJ
cord-023168-cd7adns8	1510	32	stroke	stroke	NN
cord-023168-cd7adns8	1510	33	by	by	IN
cord-023168-cd7adns8	1510	34	transfusions	transfusion	NNS
cord-023168-cd7adns8	1510	35	in	in	IN
cord-023168-cd7adns8	1510	36	children	child	NNS
cord-023168-cd7adns8	1510	37	with	with	IN
cord-023168-cd7adns8	1510	38	sickle	sickle	NN
cord-023168-cd7adns8	1510	39	cell	cell	NN
cord-023168-cd7adns8	1510	40	anemia	anemia	NN
cord-023168-cd7adns8	1510	41	and	and	CC
cord-023168-cd7adns8	1510	42	abnormal	abnormal	JJ
cord-023168-cd7adns8	1510	43	results	result	NNS
cord-023168-cd7adns8	1510	44	on	on	IN
cord-023168-cd7adns8	1510	45	transcranial	transcranial	JJ
cord-023168-cd7adns8	1510	46	Doppler	doppler	NN
cord-023168-cd7adns8	1510	47	ultrasonography	ultrasonography	NN
cord-023168-cd7adns8	1510	48	Silent	silent	JJ
cord-023168-cd7adns8	1510	49	infarction	infarction	NN
cord-023168-cd7adns8	1510	50	as	as	IN
cord-023168-cd7adns8	1510	51	a	a	DT
cord-023168-cd7adns8	1510	52	risk	risk	NN
cord-023168-cd7adns8	1510	53	factor	factor	NN
cord-023168-cd7adns8	1510	54	for	for	IN
cord-023168-cd7adns8	1510	55	overt	overt	JJ
cord-023168-cd7adns8	1510	56	stroke	stroke	NN
cord-023168-cd7adns8	1510	57	in	in	IN
cord-023168-cd7adns8	1510	58	children	child	NNS
cord-023168-cd7adns8	1510	59	with	with	IN
cord-023168-cd7adns8	1510	60	sickle	sickle	NN
cord-023168-cd7adns8	1510	61	cell	cell	NN
cord-023168-cd7adns8	1510	62	anemia	anemia	NN
cord-023168-cd7adns8	1510	63	:	:	:
cord-023168-cd7adns8	1511	1	A	a	DT
cord-023168-cd7adns8	1511	2	report	report	NN
cord-023168-cd7adns8	1511	3	from	from	IN
cord-023168-cd7adns8	1511	4	the	the	DT
cord-023168-cd7adns8	1511	5	Cooperative	Cooperative	NNP
cord-023168-cd7adns8	1511	6	Study	Study	NNP
cord-023168-cd7adns8	1511	7	of	of	IN
cord-023168-cd7adns8	1511	8	Sickle	Sickle	NNP
cord-023168-cd7adns8	1511	9	Cell	Cell	NNP
cord-023168-cd7adns8	1511	10	Disease	Disease	NNP
cord-023168-cd7adns8	1511	11	Nocturnal	nocturnal	JJ
cord-023168-cd7adns8	1511	12	hypoxaemia	hypoxaemia	NN
cord-023168-cd7adns8	1511	13	and	and	CC
cord-023168-cd7adns8	1511	14	central	central	JJ
cord-023168-cd7adns8	1511	15	-	-	HYPH
cord-023168-cd7adns8	1511	16	nervoussystem	nervoussystem	JJ
cord-023168-cd7adns8	1511	17	events	event	NNS
cord-023168-cd7adns8	1511	18	in	in	IN
cord-023168-cd7adns8	1511	19	sickle	sickle	NN
cord-023168-cd7adns8	1511	20	-	-	HYPH
cord-023168-cd7adns8	1511	21	cell	cell	NN
cord-023168-cd7adns8	1511	22	disease	disease	NN
cord-023168-cd7adns8	1511	23	Natural	natural	JJ
cord-023168-cd7adns8	1511	24	history	history	NN
cord-023168-cd7adns8	1511	25	of	of	IN
cord-023168-cd7adns8	1511	26	blood	blood	NN
cord-023168-cd7adns8	1511	27	pressure	pressure	NN
cord-023168-cd7adns8	1511	28	in	in	IN
cord-023168-cd7adns8	1511	29	sickle	sickle	NN
cord-023168-cd7adns8	1511	30	cell	cell	NN
cord-023168-cd7adns8	1511	31	disease	disease	NN
cord-023168-cd7adns8	1511	32	:	:	:
cord-023168-cd7adns8	1511	33	Risks	risk	NNS
cord-023168-cd7adns8	1511	34	for	for	IN
cord-023168-cd7adns8	1511	35	stroke	stroke	NN
cord-023168-cd7adns8	1511	36	and	and	CC
cord-023168-cd7adns8	1511	37	death	death	NN
cord-023168-cd7adns8	1511	38	associated	associate	VBN
cord-023168-cd7adns8	1511	39	with	with	IN
cord-023168-cd7adns8	1511	40	relative	relative	JJ
cord-023168-cd7adns8	1511	41	hypertension	hypertension	NN
cord-023168-cd7adns8	1511	42	in	in	IN
cord-023168-cd7adns8	1511	43	sickle	sickle	NN
cord-023168-cd7adns8	1511	44	cell	cell	NN
cord-023168-cd7adns8	1511	45	anemia	anemia	NN
cord-023168-cd7adns8	1511	46	Prophylaxis	Prophylaxis	NNP
cord-023168-cd7adns8	1511	47	with	with	IN
cord-023168-cd7adns8	1511	48	oral	oral	JJ
cord-023168-cd7adns8	1511	49	penicillin	penicillin	NN
cord-023168-cd7adns8	1511	50	in	in	IN
cord-023168-cd7adns8	1511	51	children	child	NNS
cord-023168-cd7adns8	1511	52	with	with	IN
cord-023168-cd7adns8	1511	53	sickle	sickle	NN
cord-023168-cd7adns8	1511	54	cell	cell	NN
cord-023168-cd7adns8	1511	55	anemia	anemia	NN
cord-023168-cd7adns8	1511	56	.	.	.
cord-023168-cd7adns8	1512	1	A	a	DT
cord-023168-cd7adns8	1512	2	randomized	randomized	JJ
cord-023168-cd7adns8	1512	3	trial	trial	NN
cord-023168-cd7adns8	1512	4	Effect	effect	NN
cord-023168-cd7adns8	1512	5	of	of	IN
cord-023168-cd7adns8	1512	6	hydroxyurea	hydroxyurea	NN
cord-023168-cd7adns8	1512	7	on	on	IN
cord-023168-cd7adns8	1512	8	the	the	DT
cord-023168-cd7adns8	1512	9	frequency	frequency	NN
cord-023168-cd7adns8	1512	10	of	of	IN
cord-023168-cd7adns8	1512	11	painful	painful	JJ
cord-023168-cd7adns8	1512	12	crises	crisis	NNS
cord-023168-cd7adns8	1512	13	in	in	IN
cord-023168-cd7adns8	1512	14	sickle	sickle	NN
cord-023168-cd7adns8	1512	15	cell	cell	NN
cord-023168-cd7adns8	1512	16	anemia	anemia	NN
cord-023168-cd7adns8	1512	17	.	.	.
cord-023168-cd7adns8	1513	1	Investigators	investigator	NNS
cord-023168-cd7adns8	1513	2	of	of	IN
cord-023168-cd7adns8	1513	3	the	the	DT
cord-023168-cd7adns8	1513	4	Multicenter	Multicenter	NNP
cord-023168-cd7adns8	1513	5	Study	Study	NNP
cord-023168-cd7adns8	1513	6	of	of	IN
cord-023168-cd7adns8	1513	7	Hydroxyurea	Hydroxyurea	NNP
cord-023168-cd7adns8	1513	8	in	in	IN
cord-023168-cd7adns8	1513	9	Sickle	Sickle	NNP
cord-023168-cd7adns8	1513	10	Cell	Cell	NNP
cord-023168-cd7adns8	1513	11	Anemia	anemia	NN
cord-023168-cd7adns8	1513	12	Effects	effect	NNS
cord-023168-cd7adns8	1513	13	of	of	IN
cord-023168-cd7adns8	1513	14	hydroxyurea	hydroxyurea	NN
cord-023168-cd7adns8	1513	15	on	on	IN
cord-023168-cd7adns8	1513	16	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1513	17	F	F	NNP
cord-023168-cd7adns8	1513	18	and	and	CC
cord-023168-cd7adns8	1513	19	water	water	NN
cord-023168-cd7adns8	1513	20	content	content	NN
cord-023168-cd7adns8	1513	21	in	in	IN
cord-023168-cd7adns8	1513	22	the	the	DT
cord-023168-cd7adns8	1513	23	red	red	JJ
cord-023168-cd7adns8	1513	24	blood	blood	NN
cord-023168-cd7adns8	1513	25	cells	cell	NNS
cord-023168-cd7adns8	1513	26	of	of	IN
cord-023168-cd7adns8	1513	27	dogs	dog	NNS
cord-023168-cd7adns8	1513	28	and	and	CC
cord-023168-cd7adns8	1513	29	of	of	IN
cord-023168-cd7adns8	1513	30	patients	patient	NNS
cord-023168-cd7adns8	1513	31	with	with	IN
cord-023168-cd7adns8	1513	32	sickle	sickle	NN
cord-023168-cd7adns8	1513	33	cell	cell	NN
cord-023168-cd7adns8	1513	34	anemia	anemia	NN
cord-023168-cd7adns8	1513	35	Hydroxyurea	Hydroxyurea	NNP
cord-023168-cd7adns8	1513	36	as	as	IN
cord-023168-cd7adns8	1513	37	an	an	DT
cord-023168-cd7adns8	1513	38	alternative	alternative	NN
cord-023168-cd7adns8	1513	39	to	to	IN
cord-023168-cd7adns8	1513	40	blood	blood	NN
cord-023168-cd7adns8	1513	41	transfusions	transfusion	NNS
cord-023168-cd7adns8	1513	42	for	for	IN
cord-023168-cd7adns8	1513	43	the	the	DT
cord-023168-cd7adns8	1513	44	prevention	prevention	NN
cord-023168-cd7adns8	1513	45	of	of	IN
cord-023168-cd7adns8	1513	46	recurrent	recurrent	JJ
cord-023168-cd7adns8	1513	47	stroke	stroke	NN
cord-023168-cd7adns8	1513	48	in	in	IN
cord-023168-cd7adns8	1513	49	children	child	NNS
cord-023168-cd7adns8	1513	50	with	with	IN
cord-023168-cd7adns8	1513	51	sickle	sickle	NN
cord-023168-cd7adns8	1513	52	cell	cell	NN
cord-023168-cd7adns8	1513	53	disease	disease	NN
cord-023168-cd7adns8	1514	1	Hydroxyurea	Hydroxyurea	NNP
cord-023168-cd7adns8	1514	2	therapy	therapy	NN
cord-023168-cd7adns8	1514	3	lowers	lower	VBZ
cord-023168-cd7adns8	1514	4	transcranial	transcranial	JJ
cord-023168-cd7adns8	1514	5	Doppler	Doppler	NNP
cord-023168-cd7adns8	1514	6	flow	flow	NN
cord-023168-cd7adns8	1514	7	velocities	velocity	NNS
cord-023168-cd7adns8	1514	8	in	in	IN
cord-023168-cd7adns8	1514	9	children	child	NNS
cord-023168-cd7adns8	1514	10	with	with	IN
cord-023168-cd7adns8	1514	11	sickle	sickle	NN
cord-023168-cd7adns8	1514	12	cell	cell	NN
cord-023168-cd7adns8	1514	13	anemia	anemia	NN
cord-023168-cd7adns8	1514	14	Alloimmunization	Alloimmunization	NNP
cord-023168-cd7adns8	1514	15	in	in	IN
cord-023168-cd7adns8	1514	16	sickle	sickle	NN
cord-023168-cd7adns8	1514	17	cell	cell	NN
cord-023168-cd7adns8	1514	18	anemia	anemia	NN
cord-023168-cd7adns8	1514	19	and	and	CC
cord-023168-cd7adns8	1514	20	transfusion	transfusion	NN
cord-023168-cd7adns8	1514	21	of	of	IN
cord-023168-cd7adns8	1514	22	racially	racially	RB
cord-023168-cd7adns8	1514	23	unmatched	unmatched	JJ
cord-023168-cd7adns8	1514	24	blood	blood	NN
cord-023168-cd7adns8	1514	25	Incentive	incentive	NN
cord-023168-cd7adns8	1514	26	spirometry	spirometry	NN
cord-023168-cd7adns8	1514	27	to	to	TO
cord-023168-cd7adns8	1514	28	prevent	prevent	VB
cord-023168-cd7adns8	1514	29	acute	acute	JJ
cord-023168-cd7adns8	1514	30	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	1514	31	complications	complication	NNS
cord-023168-cd7adns8	1514	32	in	in	IN
cord-023168-cd7adns8	1514	33	sickle	sickle	NN
cord-023168-cd7adns8	1514	34	cell	cell	NN
cord-023168-cd7adns8	1514	35	diseases	disease	NNS
cord-023168-cd7adns8	1514	36	Exchange	Exchange	NNP
cord-023168-cd7adns8	1514	37	versus	versus	IN
cord-023168-cd7adns8	1514	38	simple	simple	JJ
cord-023168-cd7adns8	1514	39	transfusion	transfusion	NN
cord-023168-cd7adns8	1514	40	for	for	IN
cord-023168-cd7adns8	1514	41	acute	acute	JJ
cord-023168-cd7adns8	1514	42	chest	chest	NN
cord-023168-cd7adns8	1514	43	syndrome	syndrome	NN
cord-023168-cd7adns8	1514	44	in	in	IN
cord-023168-cd7adns8	1514	45	sickle	sickle	NN
cord-023168-cd7adns8	1514	46	cell	cell	NN
cord-023168-cd7adns8	1514	47	anemia	anemia	NN
cord-023168-cd7adns8	1514	48	adults	adult	NNS
cord-023168-cd7adns8	1514	49	Corticosteroids	Corticosteroids	NNPS
cord-023168-cd7adns8	1514	50	for	for	IN
cord-023168-cd7adns8	1514	51	acute	acute	JJ
cord-023168-cd7adns8	1514	52	chest	chest	NN
cord-023168-cd7adns8	1514	53	syndrome	syndrome	NN
cord-023168-cd7adns8	1514	54	in	in	IN
cord-023168-cd7adns8	1514	55	children	child	NNS
cord-023168-cd7adns8	1514	56	with	with	IN
cord-023168-cd7adns8	1514	57	sickle	sickle	NN
cord-023168-cd7adns8	1514	58	cell	cell	NN
cord-023168-cd7adns8	1514	59	disease	disease	NN
cord-023168-cd7adns8	1514	60	:	:	:
cord-023168-cd7adns8	1514	61	variation	variation	NN
cord-023168-cd7adns8	1514	62	in	in	IN
cord-023168-cd7adns8	1514	63	use	use	NN
cord-023168-cd7adns8	1514	64	and	and	CC
cord-023168-cd7adns8	1514	65	association	association	NN
cord-023168-cd7adns8	1514	66	with	with	IN
cord-023168-cd7adns8	1514	67	length	length	NN
cord-023168-cd7adns8	1514	68	of	of	IN
cord-023168-cd7adns8	1514	69	stay	stay	NN
cord-023168-cd7adns8	1514	70	and	and	CC
cord-023168-cd7adns8	1514	71	readmission	readmission	VB
cord-023168-cd7adns8	1514	72	Airway	Airway	NNP
cord-023168-cd7adns8	1514	73	hyperreactivity	hyperreactivity	NN
cord-023168-cd7adns8	1514	74	detected	detect	VBN
cord-023168-cd7adns8	1514	75	by	by	IN
cord-023168-cd7adns8	1514	76	methacholine	methacholine	NN
cord-023168-cd7adns8	1514	77	challenge	challenge	NN
cord-023168-cd7adns8	1514	78	in	in	IN
cord-023168-cd7adns8	1514	79	children	child	NNS
cord-023168-cd7adns8	1514	80	with	with	IN
cord-023168-cd7adns8	1514	81	sickle	sickle	NN
cord-023168-cd7adns8	1514	82	cell	cell	NN
cord-023168-cd7adns8	1514	83	disease	disease	NN
cord-023168-cd7adns8	1514	84	Nitric	nitric	NN
cord-023168-cd7adns8	1514	85	oxide	oxide	NN
cord-023168-cd7adns8	1514	86	for	for	IN
cord-023168-cd7adns8	1514	87	inhalation	inhalation	NN
cord-023168-cd7adns8	1514	88	in	in	IN
cord-023168-cd7adns8	1514	89	the	the	DT
cord-023168-cd7adns8	1514	90	acute	acute	JJ
cord-023168-cd7adns8	1514	91	treatment	treatment	NN
cord-023168-cd7adns8	1514	92	of	of	IN
cord-023168-cd7adns8	1514	93	sickle	sickle	NN
cord-023168-cd7adns8	1514	94	cell	cell	NN
cord-023168-cd7adns8	1514	95	pain	pain	NN
cord-023168-cd7adns8	1514	96	crisis	crisis	NN
cord-023168-cd7adns8	1514	97	:	:	:
cord-023168-cd7adns8	1514	98	a	a	DT
cord-023168-cd7adns8	1514	99	randomized	randomized	JJ
cord-023168-cd7adns8	1514	100	controlled	control	VBN
cord-023168-cd7adns8	1514	101	trial	trial	NN
cord-023168-cd7adns8	1514	102	Reduction	reduction	NN
cord-023168-cd7adns8	1514	103	of	of	IN
cord-023168-cd7adns8	1514	104	painful	painful	JJ
cord-023168-cd7adns8	1514	105	vaso	vaso	JJ
cord-023168-cd7adns8	1514	106	-	-	HYPH
cord-023168-cd7adns8	1514	107	occlusive	occlusive	JJ
cord-023168-cd7adns8	1514	108	crisis	crisis	NN
cord-023168-cd7adns8	1514	109	of	of	IN
cord-023168-cd7adns8	1514	110	sickle	sickle	NN
cord-023168-cd7adns8	1514	111	cell	cell	NN
cord-023168-cd7adns8	1514	112	anaemia	anaemia	NN
cord-023168-cd7adns8	1514	113	by	by	IN
cord-023168-cd7adns8	1514	114	tinzaparin	tinzaparin	NNP
cord-023168-cd7adns8	1514	115	in	in	IN
cord-023168-cd7adns8	1514	116	a	a	DT
cord-023168-cd7adns8	1514	117	doubleblind	doubleblind	NN
cord-023168-cd7adns8	1514	118	randomized	randomized	JJ
cord-023168-cd7adns8	1514	119	trial	trial	NN
cord-023168-cd7adns8	1515	1	The	the	DT
cord-023168-cd7adns8	1515	2	use	use	NN
cord-023168-cd7adns8	1515	3	of	of	IN
cord-023168-cd7adns8	1515	4	transcranial	transcranial	JJ
cord-023168-cd7adns8	1515	5	ultrasonography	ultrasonography	NN
cord-023168-cd7adns8	1515	6	to	to	TO
cord-023168-cd7adns8	1515	7	predict	predict	VB
cord-023168-cd7adns8	1515	8	stroke	stroke	NN
cord-023168-cd7adns8	1515	9	in	in	IN
cord-023168-cd7adns8	1515	10	sickle	sickle	NN
cord-023168-cd7adns8	1515	11	cell	cell	NN
cord-023168-cd7adns8	1515	12	disease	disease	NN
cord-023168-cd7adns8	1515	13	Discontinuing	discontinue	VBG
cord-023168-cd7adns8	1515	14	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	1515	15	transfusions	transfusion	NNS
cord-023168-cd7adns8	1515	16	used	use	VBN
cord-023168-cd7adns8	1515	17	to	to	TO
cord-023168-cd7adns8	1515	18	prevent	prevent	VB
cord-023168-cd7adns8	1515	19	stroke	stroke	NN
cord-023168-cd7adns8	1515	20	in	in	IN
cord-023168-cd7adns8	1515	21	sickle	sickle	NN
cord-023168-cd7adns8	1515	22	cell	cell	NN
cord-023168-cd7adns8	1515	23	disease	disease	NN
cord-023168-cd7adns8	1515	24	Risk	risk	NN
cord-023168-cd7adns8	1515	25	of	of	IN
cord-023168-cd7adns8	1515	26	recurrent	recurrent	JJ
cord-023168-cd7adns8	1515	27	stroke	stroke	NN
cord-023168-cd7adns8	1515	28	in	in	IN
cord-023168-cd7adns8	1515	29	patients	patient	NNS
cord-023168-cd7adns8	1515	30	with	with	IN
cord-023168-cd7adns8	1515	31	sickle	sickle	NN
cord-023168-cd7adns8	1515	32	cell	cell	NN
cord-023168-cd7adns8	1515	33	disease	disease	NN
cord-023168-cd7adns8	1515	34	treated	treat	VBN
cord-023168-cd7adns8	1515	35	with	with	IN
cord-023168-cd7adns8	1515	36	erythrocyte	erythrocyte	NN
cord-023168-cd7adns8	1515	37	transfusions	transfusion	NNS
cord-023168-cd7adns8	1515	38	Complications	complication	NNS
cord-023168-cd7adns8	1515	39	associated	associate	VBN
cord-023168-cd7adns8	1515	40	with	with	IN
cord-023168-cd7adns8	1515	41	sickle	sickle	NN
cord-023168-cd7adns8	1515	42	cell	cell	NN
cord-023168-cd7adns8	1515	43	trait	trait	NN
cord-023168-cd7adns8	1515	44	:	:	:
cord-023168-cd7adns8	1515	45	a	a	DT
cord-023168-cd7adns8	1515	46	brief	brief	JJ
cord-023168-cd7adns8	1515	47	narrative	narrative	NN
cord-023168-cd7adns8	1515	48	review	review	NN
cord-023168-cd7adns8	1515	49	Thalassaemias	Thalassaemias	NNP
cord-023168-cd7adns8	1515	50	and	and	CC
cord-023168-cd7adns8	1515	51	related	related	JJ
cord-023168-cd7adns8	1515	52	disorders	disorder	NNS
cord-023168-cd7adns8	1515	53	:	:	:
cord-023168-cd7adns8	1515	54	quantitative	quantitative	JJ
cord-023168-cd7adns8	1515	55	disorders	disorder	NNS
cord-023168-cd7adns8	1515	56	of	of	IN
cord-023168-cd7adns8	1515	57	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1515	58	synthesis	synthesis	NN
cord-023168-cd7adns8	1516	1	A	a	DT
cord-023168-cd7adns8	1516	2	series	series	NN
cord-023168-cd7adns8	1516	3	of	of	IN
cord-023168-cd7adns8	1516	4	cases	case	NNS
cord-023168-cd7adns8	1516	5	of	of	IN
cord-023168-cd7adns8	1516	6	splenomegaly	splenomegaly	NN
cord-023168-cd7adns8	1516	7	in	in	IN
cord-023168-cd7adns8	1516	8	children	child	NNS
cord-023168-cd7adns8	1516	9	with	with	IN
cord-023168-cd7adns8	1516	10	anemia	anemia	NN
cord-023168-cd7adns8	1516	11	and	and	CC
cord-023168-cd7adns8	1516	12	peculiar	peculiar	JJ
cord-023168-cd7adns8	1516	13	bone	bone	NN
cord-023168-cd7adns8	1516	14	changes	change	VBZ
cord-023168-cd7adns8	1516	15	Mediterranean	mediterranean	JJ
cord-023168-cd7adns8	1516	16	disease	disease	NN
cord-023168-cd7adns8	1516	17	-thalassaemia	-thalassaemia	.
cord-023168-cd7adns8	1517	1	(	(	-LRB-
cord-023168-cd7adns8	1517	2	erythroblastic	erythroblastic	JJ
cord-023168-cd7adns8	1517	3	anemia	anemia	NN
cord-023168-cd7adns8	1517	4	of	of	IN
cord-023168-cd7adns8	1517	5	Cooley	Cooley	NNP
cord-023168-cd7adns8	1517	6	)	)	-RRB-
cord-023168-cd7adns8	1517	7	:	:	:
cord-023168-cd7adns8	1518	1	Associated	associated	JJ
cord-023168-cd7adns8	1518	2	pigment	pigment	NN
cord-023168-cd7adns8	1518	3	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1518	4	simulating	simulate	VBG
cord-023168-cd7adns8	1518	5	hemochromatosis	hemochromatosis	NN
cord-023168-cd7adns8	1518	6	Global	global	JJ
cord-023168-cd7adns8	1518	7	epidemiology	epidemiology	NN
cord-023168-cd7adns8	1518	8	of	of	IN
cord-023168-cd7adns8	1518	9	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1518	10	disorders	disorder	NNS
cord-023168-cd7adns8	1518	11	and	and	CC
cord-023168-cd7adns8	1518	12	derived	derive	VBN
cord-023168-cd7adns8	1518	13	service	service	NN
cord-023168-cd7adns8	1518	14	indicators	indicator	NNS
cord-023168-cd7adns8	1519	1	The	the	DT
cord-023168-cd7adns8	1519	2	inherited	inherit	VBN
cord-023168-cd7adns8	1519	3	diseases	disease	NNS
cord-023168-cd7adns8	1519	4	of	of	IN
cord-023168-cd7adns8	1519	5	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1519	6	are	be	VBP
cord-023168-cd7adns8	1519	7	an	an	DT
cord-023168-cd7adns8	1519	8	emerging	emerge	VBG
cord-023168-cd7adns8	1519	9	global	global	JJ
cord-023168-cd7adns8	1519	10	health	health	NN
cord-023168-cd7adns8	1519	11	burden	burden	NN
cord-023168-cd7adns8	1520	1	The	the	DT
cord-023168-cd7adns8	1520	2	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	1520	3	Syndromes	Syndromes	NNP
cord-023168-cd7adns8	1520	4	Pathophysiology	Pathophysiology	NNP
cord-023168-cd7adns8	1520	5	of	of	IN
cord-023168-cd7adns8	1520	6	beta	beta	NN
cord-023168-cd7adns8	1520	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1520	8	-a	-a	HYPH
cord-023168-cd7adns8	1520	9	guide	guide	NN
cord-023168-cd7adns8	1520	10	to	to	IN
cord-023168-cd7adns8	1520	11	molecular	molecular	JJ
cord-023168-cd7adns8	1520	12	therapies	therapy	NNS
cord-023168-cd7adns8	1520	13	Beta	beta	NN
cord-023168-cd7adns8	1520	14	-	-	HYPH
cord-023168-cd7adns8	1520	15	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1520	16	intermedia	intermedia	NN
cord-023168-cd7adns8	1520	17	:	:	:
cord-023168-cd7adns8	1520	18	is	be	VBZ
cord-023168-cd7adns8	1520	19	it	-PRON-	PRP
cord-023168-cd7adns8	1520	20	possible	possible	JJ
cord-023168-cd7adns8	1520	21	consistently	consistently	RB
cord-023168-cd7adns8	1520	22	to	to	TO
cord-023168-cd7adns8	1520	23	predict	predict	VB
cord-023168-cd7adns8	1520	24	phenotype	phenotype	NN
cord-023168-cd7adns8	1520	25	from	from	IN
cord-023168-cd7adns8	1520	26	genotype	genotype	NN
cord-023168-cd7adns8	1520	27	?	?	.
cord-023168-cd7adns8	1521	1	Relationship	relationship	NN
cord-023168-cd7adns8	1521	2	between	between	IN
cord-023168-cd7adns8	1521	3	genotype	genotype	NN
cord-023168-cd7adns8	1521	4	and	and	CC
cord-023168-cd7adns8	1521	5	phenotype	phenotype	NN
cord-023168-cd7adns8	1521	6	.	.	.
cord-023168-cd7adns8	1522	1	Thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1522	2	intermedia	intermedia	NN
cord-023168-cd7adns8	1522	3	Alpha	alpha	NN
cord-023168-cd7adns8	1522	4	-	-	HYPH
cord-023168-cd7adns8	1522	5	thalssemia	thalssemia	NN
cord-023168-cd7adns8	1522	6	Hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1522	7	H	H	NNP
cord-023168-cd7adns8	1522	8	disease	disease	NN
cord-023168-cd7adns8	1522	9	and	and	CC
cord-023168-cd7adns8	1522	10	mental	mental	JJ
cord-023168-cd7adns8	1522	11	retardation	retardation	NN
cord-023168-cd7adns8	1522	12	:	:	:
cord-023168-cd7adns8	1522	13	a	a	DT
cord-023168-cd7adns8	1522	14	new	new	JJ
cord-023168-cd7adns8	1522	15	syndrome	syndrome	NN
cord-023168-cd7adns8	1522	16	or	or	CC
cord-023168-cd7adns8	1522	17	a	a	DT
cord-023168-cd7adns8	1522	18	remarkable	remarkable	JJ
cord-023168-cd7adns8	1522	19	coincidence	coincidence	NN
cord-023168-cd7adns8	1522	20	?	?	.
cord-023168-cd7adns8	1523	1	Acquired	acquire	VBN
cord-023168-cd7adns8	1523	2	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1523	3	H	H	NNP
cord-023168-cd7adns8	1523	4	disease	disease	NN
cord-023168-cd7adns8	1523	5	in	in	IN
cord-023168-cd7adns8	1523	6	leukemia	leukemia	NN
cord-023168-cd7adns8	1523	7	:	:	:
cord-023168-cd7adns8	1524	1	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	1524	2	and	and	CC
cord-023168-cd7adns8	1524	3	molecular	molecular	JJ
cord-023168-cd7adns8	1524	4	basis	basis	NN
cord-023168-cd7adns8	1524	5	Pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	1524	6	of	of	IN
cord-023168-cd7adns8	1524	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1525	1	The	the	DT
cord-023168-cd7adns8	1525	2	beta	beta	JJ
cord-023168-cd7adns8	1525	3	-	-	HYPH
cord-023168-cd7adns8	1525	4	thalassaemias	thalassaemias	NNP
cord-023168-cd7adns8	1525	5	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	1525	6	minor	minor	JJ
cord-023168-cd7adns8	1525	7	,	,	,
cord-023168-cd7adns8	1525	8	the	the	DT
cord-023168-cd7adns8	1525	9	Gilbert	Gilbert	NNP
cord-023168-cd7adns8	1525	10	mutation	mutation	NN
cord-023168-cd7adns8	1525	11	,	,	,
cord-023168-cd7adns8	1525	12	and	and	CC
cord-023168-cd7adns8	1525	13	the	the	DT
cord-023168-cd7adns8	1525	14	risk	risk	NN
cord-023168-cd7adns8	1525	15	of	of	IN
cord-023168-cd7adns8	1525	16	gallstones	gallstone	NNS
cord-023168-cd7adns8	1525	17	Thromboembolic	Thromboembolic	NNP
cord-023168-cd7adns8	1525	18	events	event	NNS
cord-023168-cd7adns8	1525	19	in	in	IN
cord-023168-cd7adns8	1525	20	beta	beta	NN
cord-023168-cd7adns8	1525	21	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1525	22	major	major	NN
cord-023168-cd7adns8	1525	23	:	:	:
cord-023168-cd7adns8	1525	24	an	an	DT
cord-023168-cd7adns8	1525	25	Italian	italian	JJ
cord-023168-cd7adns8	1525	26	multicenter	multicenter	JJ
cord-023168-cd7adns8	1525	27	study	study	NN
cord-023168-cd7adns8	1525	28	Optimal	Optimal	NNP
cord-023168-cd7adns8	1525	29	management	management	NN
cord-023168-cd7adns8	1525	30	of	of	IN
cord-023168-cd7adns8	1525	31	β	β	NNP
cord-023168-cd7adns8	1525	32	thalassaemiaintermedia	thalassaemiaintermedia	NNP
cord-023168-cd7adns8	1526	1	A	a	DT
cord-023168-cd7adns8	1526	2	simple	simple	JJ
cord-023168-cd7adns8	1526	3	index	index	NN
cord-023168-cd7adns8	1526	4	for	for	IN
cord-023168-cd7adns8	1526	5	initiating	initiate	VBG
cord-023168-cd7adns8	1526	6	transfusion	transfusion	NN
cord-023168-cd7adns8	1526	7	treatment	treatment	NN
cord-023168-cd7adns8	1526	8	in	in	IN
cord-023168-cd7adns8	1526	9	thalassaemiaintermedia	thalassaemiaintermedia	NNP
cord-023168-cd7adns8	1526	10	Osteoporosis	Osteoporosis	NNP
cord-023168-cd7adns8	1526	11	in	in	IN
cord-023168-cd7adns8	1526	12	β	β	NN
cord-023168-cd7adns8	1526	13	-	-	HYPH
cord-023168-cd7adns8	1526	14	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1526	15	:	:	:
cord-023168-cd7adns8	1527	1	clinical	clinical	JJ
cord-023168-cd7adns8	1527	2	and	and	CC
cord-023168-cd7adns8	1527	3	genetic	genetic	JJ
cord-023168-cd7adns8	1527	4	aspects	aspect	NNS
cord-023168-cd7adns8	1527	5	Osteoporosis	osteoporosis	NN
cord-023168-cd7adns8	1527	6	in	in	IN
cord-023168-cd7adns8	1527	7	beta	beta	JJ
cord-023168-cd7adns8	1527	8	-	-	HYPH
cord-023168-cd7adns8	1527	9	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1527	10	major	major	JJ
cord-023168-cd7adns8	1527	11	patients	patient	NNS
cord-023168-cd7adns8	1527	12	:	:	:
cord-023168-cd7adns8	1527	13	analysis	analysis	NN
cord-023168-cd7adns8	1527	14	of	of	IN
cord-023168-cd7adns8	1527	15	the	the	DT
cord-023168-cd7adns8	1527	16	genetic	genetic	JJ
cord-023168-cd7adns8	1527	17	background	background	NN
cord-023168-cd7adns8	1527	18	Endocrine	Endocrine	NNP
cord-023168-cd7adns8	1527	19	investigation	investigation	NN
cord-023168-cd7adns8	1527	20	and	and	CC
cord-023168-cd7adns8	1527	21	follow	follow	VB
cord-023168-cd7adns8	1527	22	up	up	RP
cord-023168-cd7adns8	1527	23	in	in	IN
cord-023168-cd7adns8	1527	24	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1527	25	Italian	Italian	NNP
cord-023168-cd7adns8	1527	26	Society	Society	NNP
cord-023168-cd7adns8	1527	27	for	for	IN
cord-023168-cd7adns8	1527	28	the	the	DT
cord-023168-cd7adns8	1527	29	Study	Study	NNP
cord-023168-cd7adns8	1527	30	of	of	IN
cord-023168-cd7adns8	1527	31	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	1527	32	and	and	CC
cord-023168-cd7adns8	1527	33	Haemoglobinopathies	Haemoglobinopathies	NNPS
cord-023168-cd7adns8	1527	34	;	;	:
cord-023168-cd7adns8	1527	35	Italian	Italian	NNP
cord-023168-cd7adns8	1527	36	Association	Association	NNP
cord-023168-cd7adns8	1527	37	for	for	IN
cord-023168-cd7adns8	1527	38	the	the	DT
cord-023168-cd7adns8	1527	39	Study	Study	NNP
cord-023168-cd7adns8	1527	40	of	of	IN
cord-023168-cd7adns8	1527	41	the	the	DT
cord-023168-cd7adns8	1527	42	Liver	liver	NN
cord-023168-cd7adns8	1527	43	.	.	.
cord-023168-cd7adns8	1528	1	Management	management	NN
cord-023168-cd7adns8	1528	2	of	of	IN
cord-023168-cd7adns8	1528	3	chronic	chronic	JJ
cord-023168-cd7adns8	1528	4	viral	viral	JJ
cord-023168-cd7adns8	1528	5	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1528	6	in	in	IN
cord-023168-cd7adns8	1528	7	patients	patient	NNS
cord-023168-cd7adns8	1528	8	with	with	IN
cord-023168-cd7adns8	1528	9	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1528	10	:	:	:
cord-023168-cd7adns8	1528	11	recommendations	recommendation	NNS
cord-023168-cd7adns8	1528	12	from	from	IN
cord-023168-cd7adns8	1528	13	an	an	DT
cord-023168-cd7adns8	1528	14	international	international	JJ
cord-023168-cd7adns8	1528	15	panel	panel	NN
cord-023168-cd7adns8	1528	16	Effects	effect	NNS
cord-023168-cd7adns8	1528	17	of	of	IN
cord-023168-cd7adns8	1528	18	iron	iron	NN
cord-023168-cd7adns8	1528	19	overload	overload	NN
cord-023168-cd7adns8	1528	20	and	and	CC
cord-023168-cd7adns8	1528	21	hepatitis	hepatitis	NN
cord-023168-cd7adns8	1528	22	C	C	NNP
cord-023168-cd7adns8	1528	23	virus	virus	NN
cord-023168-cd7adns8	1528	24	positivity	positivity	NN
cord-023168-cd7adns8	1528	25	in	in	IN
cord-023168-cd7adns8	1528	26	determining	determine	VBG
cord-023168-cd7adns8	1528	27	progression	progression	NN
cord-023168-cd7adns8	1528	28	of	of	IN
cord-023168-cd7adns8	1528	29	liver	liver	NN
cord-023168-cd7adns8	1528	30	fibrosis	fibrosis	NN
cord-023168-cd7adns8	1528	31	in	in	IN
cord-023168-cd7adns8	1528	32	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1528	33	following	follow	VBG
cord-023168-cd7adns8	1528	34	bone	bone	NN
cord-023168-cd7adns8	1528	35	marrow	marrow	NN
cord-023168-cd7adns8	1528	36	transplantation	transplantation	NN
cord-023168-cd7adns8	1528	37	Cardiac	Cardiac	NNP
cord-023168-cd7adns8	1528	38	iron	iron	NN
cord-023168-cd7adns8	1528	39	and	and	CC
cord-023168-cd7adns8	1528	40	cardiac	cardiac	JJ
cord-023168-cd7adns8	1528	41	disease	disease	NN
cord-023168-cd7adns8	1528	42	in	in	IN
cord-023168-cd7adns8	1528	43	males	male	NNS
cord-023168-cd7adns8	1528	44	and	and	CC
cord-023168-cd7adns8	1528	45	females	female	NNS
cord-023168-cd7adns8	1528	46	with	with	IN
cord-023168-cd7adns8	1528	47	transfusion	transfusion	NN
cord-023168-cd7adns8	1528	48	-	-	HYPH
cord-023168-cd7adns8	1528	49	dependent	dependent	JJ
cord-023168-cd7adns8	1528	50	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1528	51	major	major	NN
cord-023168-cd7adns8	1528	52	:	:	:
cord-023168-cd7adns8	1528	53	a	a	DT
cord-023168-cd7adns8	1528	54	T2	T2	NNP
cord-023168-cd7adns8	1528	55	*	*	NFP
cord-023168-cd7adns8	1528	56	MRI	MRI	NNP
cord-023168-cd7adns8	1528	57	study	study	NN
cord-023168-cd7adns8	1528	58	Guideline	Guideline	NNP
cord-023168-cd7adns8	1528	59	recommendations	recommendation	NNS
cord-023168-cd7adns8	1528	60	for	for	IN
cord-023168-cd7adns8	1528	61	heart	heart	NN
cord-023168-cd7adns8	1528	62	complications	complication	NNS
cord-023168-cd7adns8	1528	63	in	in	IN
cord-023168-cd7adns8	1528	64	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1528	65	major	major	JJ
cord-023168-cd7adns8	1528	66	Cardiac	Cardiac	NNP
cord-023168-cd7adns8	1528	67	T2	T2	NNP
cord-023168-cd7adns8	1528	68	*	*	NFP
cord-023168-cd7adns8	1528	69	magnetic	magnetic	JJ
cord-023168-cd7adns8	1528	70	resonance	resonance	NN
cord-023168-cd7adns8	1528	71	for	for	IN
cord-023168-cd7adns8	1528	72	prediction	prediction	NN
cord-023168-cd7adns8	1528	73	of	of	IN
cord-023168-cd7adns8	1528	74	cardiac	cardiac	JJ
cord-023168-cd7adns8	1528	75	complications	complication	NNS
cord-023168-cd7adns8	1528	76	in	in	IN
cord-023168-cd7adns8	1528	77	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1528	78	major	major	JJ
cord-023168-cd7adns8	1528	79	Hypogonadism	Hypogonadism	NNP
cord-023168-cd7adns8	1528	80	,	,	,
cord-023168-cd7adns8	1528	81	diabetes	diabetes	NN
cord-023168-cd7adns8	1528	82	mellitus	mellitus	NN
cord-023168-cd7adns8	1528	83	,	,	,
cord-023168-cd7adns8	1528	84	hypothyroidism	hypothyroidism	NN
cord-023168-cd7adns8	1528	85	,	,	,
cord-023168-cd7adns8	1528	86	hypoparathyroidism	hypoparathyroidism	NN
cord-023168-cd7adns8	1528	87	:	:	:
cord-023168-cd7adns8	1529	1	incidence	incidence	NN
cord-023168-cd7adns8	1529	2	and	and	CC
cord-023168-cd7adns8	1529	3	prevalence	prevalence	NN
cord-023168-cd7adns8	1529	4	related	relate	VBN
cord-023168-cd7adns8	1529	5	to	to	IN
cord-023168-cd7adns8	1529	6	iron	iron	NN
cord-023168-cd7adns8	1529	7	overload	overload	NN
cord-023168-cd7adns8	1529	8	and	and	CC
cord-023168-cd7adns8	1529	9	chelation	chelation	NN
cord-023168-cd7adns8	1529	10	therapy	therapy	NN
cord-023168-cd7adns8	1529	11	in	in	IN
cord-023168-cd7adns8	1529	12	patients	patient	NNS
cord-023168-cd7adns8	1529	13	with	with	IN
cord-023168-cd7adns8	1529	14	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1529	15	major	major	NN
cord-023168-cd7adns8	1529	16	followed	follow	VBD
cord-023168-cd7adns8	1529	17	from	from	IN
cord-023168-cd7adns8	1529	18	1980	1980	CD
cord-023168-cd7adns8	1529	19	to	to	IN
cord-023168-cd7adns8	1529	20	2007	2007	CD
cord-023168-cd7adns8	1529	21	in	in	IN
cord-023168-cd7adns8	1529	22	the	the	DT
cord-023168-cd7adns8	1529	23	Ferrara	Ferrara	NNP
cord-023168-cd7adns8	1529	24	Centre	Centre	NNP
cord-023168-cd7adns8	1529	25	Diabetes	diabete	VBZ
cord-023168-cd7adns8	1529	26	mellitus	mellitus	NN
cord-023168-cd7adns8	1529	27	and	and	CC
cord-023168-cd7adns8	1529	28	impaired	impair	VBD
cord-023168-cd7adns8	1529	29	glucose	glucose	NN
cord-023168-cd7adns8	1529	30	tolerance	tolerance	NN
cord-023168-cd7adns8	1529	31	in	in	IN
cord-023168-cd7adns8	1529	32	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1529	33	major	major	JJ
cord-023168-cd7adns8	1529	34	:	:	:
cord-023168-cd7adns8	1529	35	incidence	incidence	NN
cord-023168-cd7adns8	1529	36	,	,	,
cord-023168-cd7adns8	1529	37	prevalence	prevalence	NN
cord-023168-cd7adns8	1529	38	,	,	,
cord-023168-cd7adns8	1529	39	risk	risk	NN
cord-023168-cd7adns8	1529	40	factors	factor	NNS
cord-023168-cd7adns8	1529	41	and	and	CC
cord-023168-cd7adns8	1529	42	survival	survival	NN
cord-023168-cd7adns8	1529	43	in	in	IN
cord-023168-cd7adns8	1529	44	patients	patient	NNS
cord-023168-cd7adns8	1529	45	followed	follow	VBN
cord-023168-cd7adns8	1529	46	in	in	IN
cord-023168-cd7adns8	1529	47	the	the	DT
cord-023168-cd7adns8	1529	48	Ferrara	Ferrara	NNP
cord-023168-cd7adns8	1529	49	Center	Center	NNP
cord-023168-cd7adns8	1529	50	Complications	Complications	NNPS
cord-023168-cd7adns8	1529	51	of	of	IN
cord-023168-cd7adns8	1529	52	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1529	53	major	major	JJ
cord-023168-cd7adns8	1529	54	and	and	CC
cord-023168-cd7adns8	1529	55	their	-PRON-	PRP$
cord-023168-cd7adns8	1529	56	treatment	treatment	NN
cord-023168-cd7adns8	1529	57	H63D	h63d	NN
cord-023168-cd7adns8	1529	58	mutation	mutation	NN
cord-023168-cd7adns8	1529	59	in	in	IN
cord-023168-cd7adns8	1529	60	the	the	DT
cord-023168-cd7adns8	1529	61	HFE	HFE	NNP
cord-023168-cd7adns8	1529	62	gene	gene	NN
cord-023168-cd7adns8	1529	63	increases	increase	VBZ
cord-023168-cd7adns8	1529	64	iron	iron	NN
cord-023168-cd7adns8	1529	65	overload	overload	NN
cord-023168-cd7adns8	1529	66	in	in	IN
cord-023168-cd7adns8	1529	67	beta	beta	JJ
cord-023168-cd7adns8	1529	68	-	-	HYPH
cord-023168-cd7adns8	1529	69	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1529	70	carriers	carrier	NNS
cord-023168-cd7adns8	1529	71	How	how	WRB
cord-023168-cd7adns8	1529	72	I	-PRON-	PRP
cord-023168-cd7adns8	1529	73	treat	treat	VBP
cord-023168-cd7adns8	1529	74	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1529	75	Guidelines	Guidelines	NNPS
cord-023168-cd7adns8	1529	76	for	for	IN
cord-023168-cd7adns8	1529	77	the	the	DT
cord-023168-cd7adns8	1529	78	Clinical	Clinical	NNP
cord-023168-cd7adns8	1529	79	Management	Management	NNP
cord-023168-cd7adns8	1529	80	of	of	IN
cord-023168-cd7adns8	1529	81	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	1529	82	Insight	Insight	NNP
cord-023168-cd7adns8	1529	83	onto	onto	IN
cord-023168-cd7adns8	1529	84	the	the	DT
cord-023168-cd7adns8	1529	85	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	1529	86	and	and	CC
cord-023168-cd7adns8	1529	87	clinical	clinical	JJ
cord-023168-cd7adns8	1529	88	complications	complication	NNS
cord-023168-cd7adns8	1529	89	of	of	IN
cord-023168-cd7adns8	1529	90	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1529	91	intermedia	intermedia	NN
cord-023168-cd7adns8	1529	92	Overview	Overview	NNP
cord-023168-cd7adns8	1529	93	on	on	IN
cord-023168-cd7adns8	1529	94	practices	practice	NNS
cord-023168-cd7adns8	1529	95	in	in	IN
cord-023168-cd7adns8	1529	96	thalassaemiaintermedia	thalassaemiaintermedia	NNP
cord-023168-cd7adns8	1529	97	management	management	NN
cord-023168-cd7adns8	1529	98	aiming	aim	VBG
cord-023168-cd7adns8	1529	99	for	for	IN
cord-023168-cd7adns8	1529	100	lowering	lower	VBG
cord-023168-cd7adns8	1529	101	complication	complication	NN
cord-023168-cd7adns8	1529	102	rates	rate	NNS
cord-023168-cd7adns8	1529	103	across	across	IN
cord-023168-cd7adns8	1529	104	a	a	DT
cord-023168-cd7adns8	1529	105	region	region	NN
cord-023168-cd7adns8	1529	106	of	of	IN
cord-023168-cd7adns8	1529	107	endemicity	endemicity	NN
cord-023168-cd7adns8	1529	108	:	:	:
cord-023168-cd7adns8	1530	1	the	the	DT
cord-023168-cd7adns8	1530	2	OPTIMAL	OPTIMAL	NNP
cord-023168-cd7adns8	1530	3	CARE	CARE	NNP
cord-023168-cd7adns8	1530	4	study	study	NN
cord-023168-cd7adns8	1530	5	Thalassaemia	Thalassaemia	NNP
cord-023168-cd7adns8	1530	6	Intermedia	Intermedia	NNP
cord-023168-cd7adns8	1530	7	:	:	:
cord-023168-cd7adns8	1530	8	revisited	revisit	VBN
cord-023168-cd7adns8	1530	9	Laboratory	laboratory	NN
cord-023168-cd7adns8	1530	10	techniques	technique	NNS
cord-023168-cd7adns8	1530	11	for	for	IN
cord-023168-cd7adns8	1530	12	the	the	DT
cord-023168-cd7adns8	1530	13	identification	identification	NN
cord-023168-cd7adns8	1530	14	of	of	IN
cord-023168-cd7adns8	1530	15	abnormalities	abnormality	NNS
cord-023168-cd7adns8	1530	16	of	of	IN
cord-023168-cd7adns8	1530	17	globin	globin	NN
cord-023168-cd7adns8	1530	18	chain	chain	NN
cord-023168-cd7adns8	1530	19	synthesis	synthesis	NN
cord-023168-cd7adns8	1530	20	.	.	.
cord-023168-cd7adns8	1531	1	Haemoglobinopathy	Haemoglobinopathy	NNP
cord-023168-cd7adns8	1531	2	Diagnosis	diagnosis	NN
cord-023168-cd7adns8	1531	3	Changes	change	NNS
cord-023168-cd7adns8	1531	4	of	of	IN
cord-023168-cd7adns8	1531	5	trace	trace	NN
cord-023168-cd7adns8	1531	6	minerals	mineral	NNS
cord-023168-cd7adns8	1531	7	(	(	-LRB-
cord-023168-cd7adns8	1531	8	serum	serum	NN
cord-023168-cd7adns8	1531	9	iron	iron	NN
cord-023168-cd7adns8	1531	10	,	,	,
cord-023168-cd7adns8	1531	11	zinc	zinc	NN
cord-023168-cd7adns8	1531	12	,	,	,
cord-023168-cd7adns8	1531	13	copper	copper	NN
cord-023168-cd7adns8	1531	14	and	and	CC
cord-023168-cd7adns8	1531	15	magnesium	magnesium	NN
cord-023168-cd7adns8	1531	16	)	)	-RRB-
cord-023168-cd7adns8	1531	17	in	in	IN
cord-023168-cd7adns8	1531	18	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1531	19	Effects	effect	NNS
cord-023168-cd7adns8	1531	20	of	of	IN
cord-023168-cd7adns8	1531	21	iron	iron	NN
cord-023168-cd7adns8	1531	22	overload	overload	NN
cord-023168-cd7adns8	1531	23	on	on	IN
cord-023168-cd7adns8	1531	24	ascorbic	ascorbic	NN
cord-023168-cd7adns8	1531	25	acid	acid	NN
cord-023168-cd7adns8	1531	26	metabolism	metabolism	NN
cord-023168-cd7adns8	1532	1	Bonemarrow	Bonemarrow	NNP
cord-023168-cd7adns8	1532	2	failure	failure	NN
cord-023168-cd7adns8	1532	3	due	due	JJ
cord-023168-cd7adns8	1532	4	to	to	IN
cord-023168-cd7adns8	1532	5	relative	relative	JJ
cord-023168-cd7adns8	1532	6	nutritional	nutritional	JJ
cord-023168-cd7adns8	1532	7	deficiency	deficiency	NN
cord-023168-cd7adns8	1532	8	in	in	IN
cord-023168-cd7adns8	1532	9	Cooley	Cooley	NNP
cord-023168-cd7adns8	1532	10	's	's	POS
cord-023168-cd7adns8	1532	11	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1532	12	anemia	anemia	NN
cord-023168-cd7adns8	1532	13	:	:	:
cord-023168-cd7adns8	1533	1	Painful	painful	JJ
cord-023168-cd7adns8	1533	2	erythropoietic	erythropoietic	JJ
cord-023168-cd7adns8	1533	3	crises	crisis	NNS
cord-023168-cd7adns8	1533	4	in	in	IN
cord-023168-cd7adns8	1533	5	response	response	NN
cord-023168-cd7adns8	1533	6	to	to	IN
cord-023168-cd7adns8	1533	7	folic	folic	RB
cord-023168-cd7adns8	1533	8	acid	acid	NN
cord-023168-cd7adns8	1533	9	Global	global	JJ
cord-023168-cd7adns8	1533	10	epidemiology	epidemiology	NN
cord-023168-cd7adns8	1533	11	of	of	IN
cord-023168-cd7adns8	1533	12	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1533	13	disorders	disorder	NNS
cord-023168-cd7adns8	1533	14	and	and	CC
cord-023168-cd7adns8	1533	15	derived	derive	VBN
cord-023168-cd7adns8	1533	16	service	service	NN
cord-023168-cd7adns8	1533	17	indicators	indicator	NNS
cord-023168-cd7adns8	1533	18	Guidelines	Guidelines	NNPS
cord-023168-cd7adns8	1533	19	for	for	IN
cord-023168-cd7adns8	1533	20	the	the	DT
cord-023168-cd7adns8	1533	21	clinical	clinical	JJ
cord-023168-cd7adns8	1533	22	management	management	NN
cord-023168-cd7adns8	1533	23	of	of	IN
cord-023168-cd7adns8	1533	24	thalassaemia	thalassaemia	NNP
cord-023168-cd7adns8	1533	25	Real	Real	NNP
cord-023168-cd7adns8	1533	26	-	-	HYPH
cord-023168-cd7adns8	1533	27	World	world	NN
cord-023168-cd7adns8	1533	28	Use	use	NN
cord-023168-cd7adns8	1533	29	of	of	IN
cord-023168-cd7adns8	1533	30	Iron	Iron	NNP
cord-023168-cd7adns8	1533	31	Chelators	Chelators	NNP
cord-023168-cd7adns8	1534	1	Optimizing	optimize	VBG
cord-023168-cd7adns8	1534	2	iron	iron	NN
cord-023168-cd7adns8	1534	3	chelation	chelation	NN
cord-023168-cd7adns8	1534	4	strategies	strategy	NNS
cord-023168-cd7adns8	1534	5	in	in	IN
cord-023168-cd7adns8	1534	6	beta	beta	NN
cord-023168-cd7adns8	1534	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1534	8	major	major	JJ
cord-023168-cd7adns8	1534	9	Marrow	Marrow	NNP
cord-023168-cd7adns8	1534	10	transplantation	transplantation	NN
cord-023168-cd7adns8	1534	11	for	for	IN
cord-023168-cd7adns8	1534	12	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1534	13	Allogeneic	Allogeneic	NNP
cord-023168-cd7adns8	1534	14	stem	stem	VBP
cord-023168-cd7adns8	1534	15	cell	cell	NN
cord-023168-cd7adns8	1534	16	transplantation	transplantation	NN
cord-023168-cd7adns8	1534	17	for	for	IN
cord-023168-cd7adns8	1534	18	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1534	19	major	major	JJ
cord-023168-cd7adns8	1534	20	Fetal	fetal	JJ
cord-023168-cd7adns8	1534	21	globin	globin	NN
cord-023168-cd7adns8	1534	22	stimulant	stimulant	NN
cord-023168-cd7adns8	1534	23	therapies	therapy	NNS
cord-023168-cd7adns8	1534	24	in	in	IN
cord-023168-cd7adns8	1534	25	the	the	DT
cord-023168-cd7adns8	1534	26	beta	beta	NN
cord-023168-cd7adns8	1534	27	-	-	HYPH
cord-023168-cd7adns8	1534	28	hemoglobinopathies	hemoglobinopathy	NNS
cord-023168-cd7adns8	1534	29	:	:	:
cord-023168-cd7adns8	1535	1	principles	principle	NNS
cord-023168-cd7adns8	1535	2	and	and	CC
cord-023168-cd7adns8	1535	3	current	current	JJ
cord-023168-cd7adns8	1535	4	potential	potential	JJ
cord-023168-cd7adns8	1535	5	Hydroxyurea	Hydroxyurea	NNP
cord-023168-cd7adns8	1535	6	in	in	IN
cord-023168-cd7adns8	1535	7	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1535	8	intermedia	intermedia	NN
cord-023168-cd7adns8	1535	9	:	:	:
cord-023168-cd7adns8	1536	1	a	a	DT
cord-023168-cd7adns8	1536	2	promising	promise	VBG
cord-023168-cd7adns8	1536	3	therapy	therapy	NN
cord-023168-cd7adns8	1536	4	Therapeutic	therapeutic	JJ
cord-023168-cd7adns8	1536	5	haemoglobin	haemoglobin	NN
cord-023168-cd7adns8	1536	6	synthesis	synthesis	NN
cord-023168-cd7adns8	1536	7	in	in	IN
cord-023168-cd7adns8	1536	8	beta	beta	JJ
cord-023168-cd7adns8	1536	9	-	-	HYPH
cord-023168-cd7adns8	1536	10	thalassaemic	thalassaemic	JJ
cord-023168-cd7adns8	1536	11	mice	mouse	NNS
cord-023168-cd7adns8	1536	12	expressing	express	VBG
cord-023168-cd7adns8	1536	13	lentivirus	lentivirus	NN
cord-023168-cd7adns8	1536	14	-	-	HYPH
cord-023168-cd7adns8	1536	15	encoded	encode	VBN
cord-023168-cd7adns8	1536	16	human	human	JJ
cord-023168-cd7adns8	1536	17	betaglobin	betaglobin	NNP
cord-023168-cd7adns8	1536	18	Future	Future	NNP
cord-023168-cd7adns8	1536	19	alternative	alternative	JJ
cord-023168-cd7adns8	1536	20	therapies	therapy	NNS
cord-023168-cd7adns8	1536	21	for	for	IN
cord-023168-cd7adns8	1536	22	beta	beta	JJ
cord-023168-cd7adns8	1536	23	-	-	HYPH
cord-023168-cd7adns8	1536	24	thalassaemia	thalassaemia	NN
cord-023168-cd7adns8	1536	25	Thalassaemiascreening	Thalassaemiascreening	NNP
cord-023168-cd7adns8	1536	26	in	in	IN
cord-023168-cd7adns8	1536	27	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1536	28	Ultrasound	Ultrasound	NNP
cord-023168-cd7adns8	1536	29	measurement	measurement	NN
cord-023168-cd7adns8	1536	30	of	of	IN
cord-023168-cd7adns8	1536	31	placental	placental	JJ
cord-023168-cd7adns8	1536	32	thickness	thickness	NN
cord-023168-cd7adns8	1536	33	to	to	TO
cord-023168-cd7adns8	1536	34	detect	detect	VB
cord-023168-cd7adns8	1536	35	pregnancies	pregnancy	NNS
cord-023168-cd7adns8	1536	36	affected	affect	VBN
cord-023168-cd7adns8	1536	37	by	by	IN
cord-023168-cd7adns8	1536	38	homozygous	homozygous	JJ
cord-023168-cd7adns8	1536	39	alphathalassaemia-1	alphathalassaemia-1	NNP
cord-023168-cd7adns8	1536	40	Enzymatic	enzymatic	JJ
cord-023168-cd7adns8	1536	41	deficiency	deficiency	NN
cord-023168-cd7adns8	1536	42	in	in	IN
cord-023168-cd7adns8	1536	43	primaquine	primaquine	JJ
cord-023168-cd7adns8	1536	44	-	-	HYPH
cord-023168-cd7adns8	1536	45	sensitive	sensitive	JJ
cord-023168-cd7adns8	1536	46	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1537	1	Glucose-6-phosphate	glucose-6-phosphate	VBP
cord-023168-cd7adns8	1537	2	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1537	3	deficiency	deficiency	NN
cord-023168-cd7adns8	1538	1	Glucose-6-phosphate	glucose-6-phosphate	VBP
cord-023168-cd7adns8	1538	2	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1538	3	deficiency	deficiency	NN
cord-023168-cd7adns8	1538	4	Glucose-6-phosphate	glucose-6-phosphate	VBP
cord-023168-cd7adns8	1538	5	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1538	6	deficiency	deficiency	NN
cord-023168-cd7adns8	1538	7	:	:	:
cord-023168-cd7adns8	1538	8	a	a	DT
cord-023168-cd7adns8	1538	9	historical	historical	JJ
cord-023168-cd7adns8	1538	10	perspective	perspective	NN
cord-023168-cd7adns8	1538	11	Natural	natural	JJ
cord-023168-cd7adns8	1538	12	selection	selection	NN
cord-023168-cd7adns8	1538	13	of	of	IN
cord-023168-cd7adns8	1538	14	hemi	hemi	NNP
cord-023168-cd7adns8	1538	15	-	-	:
cord-023168-cd7adns8	1538	16	and	and	CC
cord-023168-cd7adns8	1538	17	heterozygotes	heterozygote	NNS
cord-023168-cd7adns8	1538	18	for	for	IN
cord-023168-cd7adns8	1538	19	G6PD	G6PD	NNP
cord-023168-cd7adns8	1538	20	deficiency	deficiency	NN
cord-023168-cd7adns8	1538	21	in	in	IN
cord-023168-cd7adns8	1538	22	Africa	Africa	NNP
cord-023168-cd7adns8	1538	23	by	by	IN
cord-023168-cd7adns8	1538	24	resistance	resistance	NN
cord-023168-cd7adns8	1538	25	to	to	IN
cord-023168-cd7adns8	1538	26	severe	severe	JJ
cord-023168-cd7adns8	1538	27	malaria	malaria	NN
cord-023168-cd7adns8	1539	1	The	the	DT
cord-023168-cd7adns8	1539	2	molecular	molecular	JJ
cord-023168-cd7adns8	1539	3	biology	biology	NN
cord-023168-cd7adns8	1539	4	of	of	IN
cord-023168-cd7adns8	1539	5	enzymes	enzyme	NNS
cord-023168-cd7adns8	1539	6	of	of	IN
cord-023168-cd7adns8	1539	7	erythrocyte	erythrocyte	NN
cord-023168-cd7adns8	1539	8	metabolism	metabolism	NN
cord-023168-cd7adns8	1539	9	Diabetic	diabetic	JJ
cord-023168-cd7adns8	1539	10	ketoacidosis	ketoacidosis	NN
cord-023168-cd7adns8	1539	11	does	do	VBZ
cord-023168-cd7adns8	1539	12	not	not	RB
cord-023168-cd7adns8	1539	13	precipitate	precipitate	VB
cord-023168-cd7adns8	1539	14	haemolysis	haemolysis	NN
cord-023168-cd7adns8	1539	15	in	in	IN
cord-023168-cd7adns8	1539	16	patients	patient	NNS
cord-023168-cd7adns8	1539	17	with	with	IN
cord-023168-cd7adns8	1539	18	the	the	DT
cord-023168-cd7adns8	1539	19	Mediterranean	mediterranean	JJ
cord-023168-cd7adns8	1539	20	variant	variant	NN
cord-023168-cd7adns8	1539	21	of	of	IN
cord-023168-cd7adns8	1539	22	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-023168-cd7adns8	1539	23	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1539	24	deficiency	deficiency	NN
cord-023168-cd7adns8	1539	25	Hereditary	hereditary	JJ
cord-023168-cd7adns8	1539	26	hemolyticanemias	hemolyticanemias	NN
cord-023168-cd7adns8	1539	27	due	due	IN
cord-023168-cd7adns8	1539	28	to	to	IN
cord-023168-cd7adns8	1539	29	red	red	JJ
cord-023168-cd7adns8	1539	30	blood	blood	NN
cord-023168-cd7adns8	1539	31	cell	cell	NN
cord-023168-cd7adns8	1539	32	enzyme	enzyme	NN
cord-023168-cd7adns8	1539	33	disorders	disorder	NNS
cord-023168-cd7adns8	1539	34	Glucose-6-phosphate	glucose-6-phosphate	VBP
cord-023168-cd7adns8	1539	35	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1539	36	deficiency	deficiency	NN
cord-023168-cd7adns8	1540	1	Active	active	JJ
cord-023168-cd7adns8	1540	2	involvement	involvement	NN
cord-023168-cd7adns8	1540	3	of	of	IN
cord-023168-cd7adns8	1540	4	catalase	catalase	NN
cord-023168-cd7adns8	1540	5	during	during	IN
cord-023168-cd7adns8	1540	6	hemolytic	hemolytic	JJ
cord-023168-cd7adns8	1540	7	crises	crisis	NNS
cord-023168-cd7adns8	1540	8	of	of	IN
cord-023168-cd7adns8	1540	9	favism	favism	NN
cord-023168-cd7adns8	1540	10	Glucose-6-phosphate	glucose-6-phosphate	NN
cord-023168-cd7adns8	1540	11	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1540	12	deficiency	deficiency	NN
cord-023168-cd7adns8	1540	13	:	:	:
cord-023168-cd7adns8	1540	14	a	a	DT
cord-023168-cd7adns8	1540	15	hidden	hidden	JJ
cord-023168-cd7adns8	1540	16	risk	risk	NN
cord-023168-cd7adns8	1540	17	for	for	IN
cord-023168-cd7adns8	1540	18	kernicterus	kernicterus	NNP
cord-023168-cd7adns8	1541	1	The	the	DT
cord-023168-cd7adns8	1541	2	need	need	NN
cord-023168-cd7adns8	1541	3	for	for	IN
cord-023168-cd7adns8	1541	4	neonatal	neonatal	JJ
cord-023168-cd7adns8	1541	5	glucose-6-phosphate	glucose-6-phosphate	JJ
cord-023168-cd7adns8	1541	6	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1541	7	screening	screening	NN
cord-023168-cd7adns8	1541	8	:	:	:
cord-023168-cd7adns8	1541	9	a	a	DT
cord-023168-cd7adns8	1541	10	global	global	JJ
cord-023168-cd7adns8	1541	11	perspective	perspective	NN
cord-023168-cd7adns8	1541	12	Clinical	clinical	JJ
cord-023168-cd7adns8	1541	13	practice	practice	NN
cord-023168-cd7adns8	1541	14	guideline	guideline	NN
cord-023168-cd7adns8	1541	15	:	:	:
cord-023168-cd7adns8	1541	16	management	management	NNP
cord-023168-cd7adns8	1541	17	of	of	IN
cord-023168-cd7adns8	1541	18	hyperbilirubinemia	hyperbilirubinemia	NNP
cord-023168-cd7adns8	1541	19	in	in	IN
cord-023168-cd7adns8	1541	20	the	the	DT
cord-023168-cd7adns8	1541	21	newborn	newborn	JJ
cord-023168-cd7adns8	1541	22	infant	infant	NN
cord-023168-cd7adns8	1541	23	35	35	CD
cord-023168-cd7adns8	1541	24	or	or	CC
cord-023168-cd7adns8	1541	25	more	more	JJR
cord-023168-cd7adns8	1541	26	weeks	week	NNS
cord-023168-cd7adns8	1541	27	of	of	IN
cord-023168-cd7adns8	1541	28	gestation	gestation	NN
cord-023168-cd7adns8	1541	29	Diagnosis	diagnosis	NN
cord-023168-cd7adns8	1541	30	from	from	IN
cord-023168-cd7adns8	1541	31	the	the	DT
cord-023168-cd7adns8	1541	32	blood	blood	NN
cord-023168-cd7adns8	1541	33	smear	smear	NN
cord-023168-cd7adns8	1541	34	G6PD	G6PD	NNP
cord-023168-cd7adns8	1541	35	Mediterranean	Mediterranean	NNP
cord-023168-cd7adns8	1541	36	accounts	account	VBZ
cord-023168-cd7adns8	1541	37	for	for	IN
cord-023168-cd7adns8	1541	38	the	the	DT
cord-023168-cd7adns8	1541	39	high	high	JJ
cord-023168-cd7adns8	1541	40	prevalence	prevalence	NN
cord-023168-cd7adns8	1541	41	of	of	IN
cord-023168-cd7adns8	1541	42	G6PD	G6PD	NNP
cord-023168-cd7adns8	1541	43	deficiency	deficiency	NN
cord-023168-cd7adns8	1541	44	in	in	IN
cord-023168-cd7adns8	1541	45	Kurdish	kurdish	JJ
cord-023168-cd7adns8	1541	46	Jews	Jews	NNPS
cord-023168-cd7adns8	1541	47	Red	red	JJ
cord-023168-cd7adns8	1541	48	blood	blood	NN
cord-023168-cd7adns8	1541	49	cell	cell	NN
cord-023168-cd7adns8	1541	50	deformability	deformability	NN
cord-023168-cd7adns8	1541	51	as	as	IN
cord-023168-cd7adns8	1541	52	a	a	DT
cord-023168-cd7adns8	1541	53	predictor	predictor	NN
cord-023168-cd7adns8	1541	54	of	of	IN
cord-023168-cd7adns8	1541	55	anemia	anemia	NN
cord-023168-cd7adns8	1541	56	in	in	IN
cord-023168-cd7adns8	1541	57	severe	severe	JJ
cord-023168-cd7adns8	1541	58	falciparum	falciparum	NN
cord-023168-cd7adns8	1541	59	malaria	malaria	NN
cord-023168-cd7adns8	1541	60	Phosphatidylserine	Phosphatidylserine	NNP
cord-023168-cd7adns8	1541	61	as	as	IN
cord-023168-cd7adns8	1541	62	a	a	DT
cord-023168-cd7adns8	1541	63	determinant	determinant	NN
cord-023168-cd7adns8	1541	64	of	of	IN
cord-023168-cd7adns8	1541	65	reticuloendothelial	reticuloendothelial	JJ
cord-023168-cd7adns8	1541	66	recognition	recognition	NN
cord-023168-cd7adns8	1541	67	of	of	IN
cord-023168-cd7adns8	1541	68	liposome	liposome	NN
cord-023168-cd7adns8	1541	69	models	model	NNS
cord-023168-cd7adns8	1541	70	of	of	IN
cord-023168-cd7adns8	1541	71	the	the	DT
cord-023168-cd7adns8	1541	72	erythrocyte	erythrocyte	NN
cord-023168-cd7adns8	1541	73	surface	surface	NN
cord-023168-cd7adns8	1541	74	Adhesion	adhesion	NN
cord-023168-cd7adns8	1541	75	of	of	IN
cord-023168-cd7adns8	1541	76	normal	normal	JJ
cord-023168-cd7adns8	1541	77	and	and	CC
cord-023168-cd7adns8	1541	78	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1541	79	falciparum	falciparum	NN
cord-023168-cd7adns8	1541	80	ring	ring	NN
cord-023168-cd7adns8	1541	81	-	-	HYPH
cord-023168-cd7adns8	1541	82	infected	infect	VBN
cord-023168-cd7adns8	1541	83	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1541	84	to	to	IN
cord-023168-cd7adns8	1541	85	endothelial	endothelial	JJ
cord-023168-cd7adns8	1541	86	cells	cell	NNS
cord-023168-cd7adns8	1541	87	and	and	CC
cord-023168-cd7adns8	1541	88	the	the	DT
cord-023168-cd7adns8	1541	89	placenta	placenta	NN
cord-023168-cd7adns8	1541	90	involves	involve	VBZ
cord-023168-cd7adns8	1541	91	the	the	DT
cord-023168-cd7adns8	1541	92	rhoptry	rhoptry	NN
cord-023168-cd7adns8	1541	93	-	-	HYPH
cord-023168-cd7adns8	1541	94	derived	derive	VBN
cord-023168-cd7adns8	1541	95	ring	ring	NN
cord-023168-cd7adns8	1541	96	surface	surface	NN
cord-023168-cd7adns8	1542	1	protein-2	protein-2	VBZ
cord-023168-cd7adns8	1542	2	Destabilization	destabilization	NN
cord-023168-cd7adns8	1542	3	and	and	CC
cord-023168-cd7adns8	1542	4	subsequent	subsequent	JJ
cord-023168-cd7adns8	1542	5	lysis	lysis	NN
cord-023168-cd7adns8	1542	6	of	of	IN
cord-023168-cd7adns8	1542	7	human	human	JJ
cord-023168-cd7adns8	1542	8	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1542	9	induced	induce	VBN
cord-023168-cd7adns8	1542	10	by	by	IN
cord-023168-cd7adns8	1542	11	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1542	12	falciparum	falciparum	NN
cord-023168-cd7adns8	1542	13	haem	haem	NN
cord-023168-cd7adns8	1542	14	products	product	NNS
cord-023168-cd7adns8	1542	15	Anaemia	anaemia	NN
cord-023168-cd7adns8	1542	16	of	of	IN
cord-023168-cd7adns8	1542	17	acute	acute	JJ
cord-023168-cd7adns8	1542	18	malaria	malaria	NN
cord-023168-cd7adns8	1542	19	infections	infection	NNS
cord-023168-cd7adns8	1542	20	in	in	IN
cord-023168-cd7adns8	1542	21	nonimmune	nonimmune	JJ
cord-023168-cd7adns8	1542	22	patients	patient	NNS
cord-023168-cd7adns8	1542	23	primarily	primarily	RB
cord-023168-cd7adns8	1542	24	results	result	VBZ
cord-023168-cd7adns8	1542	25	from	from	IN
cord-023168-cd7adns8	1542	26	destruction	destruction	NN
cord-023168-cd7adns8	1542	27	of	of	IN
cord-023168-cd7adns8	1542	28	uninfected	uninfected	JJ
cord-023168-cd7adns8	1542	29	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1542	30	Loss	loss	NN
cord-023168-cd7adns8	1542	31	of	of	IN
cord-023168-cd7adns8	1542	32	red	red	JJ
cord-023168-cd7adns8	1542	33	blood	blood	NN
cord-023168-cd7adns8	1542	34	cell	cell	NN
cord-023168-cd7adns8	1542	35	-	-	HYPH
cord-023168-cd7adns8	1542	36	complement	complement	NN
cord-023168-cd7adns8	1542	37	regulatory	regulatory	JJ
cord-023168-cd7adns8	1542	38	proteins	protein	NNS
cord-023168-cd7adns8	1542	39	and	and	CC
cord-023168-cd7adns8	1542	40	increased	increase	VBN
cord-023168-cd7adns8	1542	41	levels	level	NNS
cord-023168-cd7adns8	1542	42	of	of	IN
cord-023168-cd7adns8	1542	43	circulating	circulate	VBG
cord-023168-cd7adns8	1542	44	immune	immune	JJ
cord-023168-cd7adns8	1542	45	complexes	complex	NNS
cord-023168-cd7adns8	1542	46	are	be	VBP
cord-023168-cd7adns8	1542	47	associated	associate	VBN
cord-023168-cd7adns8	1542	48	with	with	IN
cord-023168-cd7adns8	1542	49	severe	severe	JJ
cord-023168-cd7adns8	1542	50	malarial	malarial	JJ
cord-023168-cd7adns8	1542	51	anemia	anemia	NN
cord-023168-cd7adns8	1542	52	Anaemia	anaemia	NN
cord-023168-cd7adns8	1542	53	in	in	IN
cord-023168-cd7adns8	1542	54	a	a	DT
cord-023168-cd7adns8	1542	55	phase	phase	NN
cord-023168-cd7adns8	1542	56	2	2	CD
cord-023168-cd7adns8	1542	57	study	study	NN
cord-023168-cd7adns8	1542	58	of	of	IN
cord-023168-cd7adns8	1542	59	a	a	DT
cord-023168-cd7adns8	1542	60	blood	blood	NN
cord-023168-cd7adns8	1542	61	stage	stage	NN
cord-023168-cd7adns8	1542	62	falciparum	falciparum	NN
cord-023168-cd7adns8	1542	63	malaria	malaria	NN
cord-023168-cd7adns8	1542	64	vaccine	vaccine	NN
cord-023168-cd7adns8	1543	1	The	the	DT
cord-023168-cd7adns8	1543	2	anaemia	anaemia	NN
cord-023168-cd7adns8	1543	3	of	of	IN
cord-023168-cd7adns8	1543	4	P.	P.	NNP
cord-023168-cd7adns8	1543	5	falciparum	falciparum	NN
cord-023168-cd7adns8	1543	6	malaria	malaria	NNP
cord-023168-cd7adns8	1543	7	Hemozoin	Hemozoin	NNP
cord-023168-cd7adns8	1543	8	-	-	:
cord-023168-cd7adns8	1543	9	and	and	CC
cord-023168-cd7adns8	1543	10	4-hydroxynonenal	4-hydroxynonenal	CD
cord-023168-cd7adns8	1543	11	-	-	HYPH
cord-023168-cd7adns8	1543	12	mediated	mediate	VBN
cord-023168-cd7adns8	1543	13	inhibition	inhibition	NN
cord-023168-cd7adns8	1543	14	of	of	IN
cord-023168-cd7adns8	1543	15	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	1543	16	.	.	.
cord-023168-cd7adns8	1544	1	Possible	possible	JJ
cord-023168-cd7adns8	1544	2	role	role	NN
cord-023168-cd7adns8	1544	3	in	in	IN
cord-023168-cd7adns8	1544	4	malarial	malarial	JJ
cord-023168-cd7adns8	1544	5	dyserythropoiesis	dyserythropoiesis	NN
cord-023168-cd7adns8	1544	6	and	and	CC
cord-023168-cd7adns8	1544	7	anemia	anemia	NN
cord-023168-cd7adns8	1544	8	Tumor	tumor	NN
cord-023168-cd7adns8	1544	9	necrosis	necrosis	NN
cord-023168-cd7adns8	1544	10	factor	factor	NN
cord-023168-cd7adns8	1544	11	may	may	MD
cord-023168-cd7adns8	1544	12	contribute	contribute	VB
cord-023168-cd7adns8	1544	13	to	to	IN
cord-023168-cd7adns8	1544	14	the	the	DT
cord-023168-cd7adns8	1544	15	anaemia	anaemia	NN
cord-023168-cd7adns8	1544	16	of	of	IN
cord-023168-cd7adns8	1544	17	malaria	malaria	NN
cord-023168-cd7adns8	1544	18	by	by	IN
cord-023168-cd7adns8	1544	19	causing	cause	VBG
cord-023168-cd7adns8	1544	20	dyserythropoiesis	dyserythropoiesis	NN
cord-023168-cd7adns8	1544	21	and	and	CC
cord-023168-cd7adns8	1544	22	erythrophagocytosis	erythrophagocytosis	NNP
cord-023168-cd7adns8	1544	23	Low	low	JJ
cord-023168-cd7adns8	1544	24	plasma	plasma	NN
cord-023168-cd7adns8	1544	25	concentrations	concentration	NNS
cord-023168-cd7adns8	1544	26	of	of	IN
cord-023168-cd7adns8	1544	27	interleukin-10	interleukin-10	NN
cord-023168-cd7adns8	1544	28	in	in	IN
cord-023168-cd7adns8	1544	29	severe	severe	JJ
cord-023168-cd7adns8	1544	30	malarial	malarial	JJ
cord-023168-cd7adns8	1544	31	anaemia	anaemia	NN
cord-023168-cd7adns8	1544	32	compared	compare	VBN
cord-023168-cd7adns8	1544	33	with	with	IN
cord-023168-cd7adns8	1544	34	cerebral	cerebral	JJ
cord-023168-cd7adns8	1544	35	and	and	CC
cord-023168-cd7adns8	1544	36	uncomplicated	uncomplicated	JJ
cord-023168-cd7adns8	1544	37	malaria	malaria	NN
cord-023168-cd7adns8	1544	38	Suppression	suppression	NN
cord-023168-cd7adns8	1544	39	of	of	IN
cord-023168-cd7adns8	1544	40	erythropoiesis	erythropoiesis	NN
cord-023168-cd7adns8	1544	41	in	in	IN
cord-023168-cd7adns8	1544	42	malarial	malarial	JJ
cord-023168-cd7adns8	1544	43	anemia	anemia	NN
cord-023168-cd7adns8	1544	44	is	be	VBZ
cord-023168-cd7adns8	1544	45	associated	associate	VBN
cord-023168-cd7adns8	1544	46	with	with	IN
cord-023168-cd7adns8	1544	47	hemozoin	hemozoin	NNP
cord-023168-cd7adns8	1544	48	in	in	IN
cord-023168-cd7adns8	1544	49	vitro	vitro	FW
cord-023168-cd7adns8	1544	50	and	and	CC
cord-023168-cd7adns8	1544	51	in	in	IN
cord-023168-cd7adns8	1544	52	vivo	vivo	NNP
cord-023168-cd7adns8	1544	53	Malariarelated	malariarelate	VBN
cord-023168-cd7adns8	1544	54	anaemia	anaemia	NN
cord-023168-cd7adns8	1544	55	Prevalence	prevalence	NN
cord-023168-cd7adns8	1544	56	of	of	IN
cord-023168-cd7adns8	1544	57	and	and	CC
cord-023168-cd7adns8	1544	58	risk	risk	NN
cord-023168-cd7adns8	1544	59	factors	factor	NNS
cord-023168-cd7adns8	1544	60	for	for	IN
cord-023168-cd7adns8	1544	61	anemia	anemia	NN
cord-023168-cd7adns8	1544	62	in	in	IN
cord-023168-cd7adns8	1544	63	young	young	JJ
cord-023168-cd7adns8	1544	64	children	child	NNS
cord-023168-cd7adns8	1544	65	in	in	IN
cord-023168-cd7adns8	1544	66	southern	southern	JJ
cord-023168-cd7adns8	1544	67	Cameroon	Cameroon	NNP
cord-023168-cd7adns8	1544	68	Severe	severe	JJ
cord-023168-cd7adns8	1544	69	anemia	anemia	NN
cord-023168-cd7adns8	1544	70	in	in	IN
cord-023168-cd7adns8	1544	71	Malawian	malawian	JJ
cord-023168-cd7adns8	1544	72	children	child	NNS
cord-023168-cd7adns8	1544	73	Malarial	malarial	JJ
cord-023168-cd7adns8	1544	74	anemia	anemia	NN
cord-023168-cd7adns8	1544	75	:	:	:
cord-023168-cd7adns8	1544	76	of	of	IN
cord-023168-cd7adns8	1544	77	mice	mouse	NNS
cord-023168-cd7adns8	1544	78	and	and	CC
cord-023168-cd7adns8	1544	79	men	man	NNS
cord-023168-cd7adns8	1544	80	Intermittent	intermittent	JJ
cord-023168-cd7adns8	1544	81	preventive	preventive	JJ
cord-023168-cd7adns8	1544	82	treatment	treatment	NN
cord-023168-cd7adns8	1544	83	with	with	IN
cord-023168-cd7adns8	1544	84	sulfadoxinepyrimethamine	sulfadoxinepyrimethamine	NN
cord-023168-cd7adns8	1544	85	against	against	IN
cord-023168-cd7adns8	1544	86	malaria	malaria	NN
cord-023168-cd7adns8	1544	87	and	and	CC
cord-023168-cd7adns8	1544	88	anemia	anemia	NN
cord-023168-cd7adns8	1544	89	in	in	IN
cord-023168-cd7adns8	1544	90	pregnant	pregnant	JJ
cord-023168-cd7adns8	1544	91	women	woman	NNS
cord-023168-cd7adns8	1545	1	Randomised	randomised	JJ
cord-023168-cd7adns8	1545	2	placebo	placebo	NN
cord-023168-cd7adns8	1545	3	-	-	HYPH
cord-023168-cd7adns8	1545	4	controlled	control	VBN
cord-023168-cd7adns8	1545	5	trial	trial	NN
cord-023168-cd7adns8	1545	6	of	of	IN
cord-023168-cd7adns8	1545	7	iron	iron	NN
cord-023168-cd7adns8	1545	8	supplementation	supplementation	NN
cord-023168-cd7adns8	1545	9	and	and	CC
cord-023168-cd7adns8	1545	10	malaria	malaria	NN
cord-023168-cd7adns8	1545	11	chemoprophylaxis	chemoprophylaxis	NNP
cord-023168-cd7adns8	1545	12	for	for	IN
cord-023168-cd7adns8	1545	13	prevention	prevention	NN
cord-023168-cd7adns8	1545	14	of	of	IN
cord-023168-cd7adns8	1545	15	severe	severe	JJ
cord-023168-cd7adns8	1545	16	anaemia	anaemia	NN
cord-023168-cd7adns8	1545	17	and	and	CC
cord-023168-cd7adns8	1545	18	malaria	malaria	NN
cord-023168-cd7adns8	1545	19	in	in	IN
cord-023168-cd7adns8	1545	20	Tanzanian	tanzanian	JJ
cord-023168-cd7adns8	1545	21	infants	infant	NNS
cord-023168-cd7adns8	1545	22	Severe	severe	JJ
cord-023168-cd7adns8	1545	23	and	and	CC
cord-023168-cd7adns8	1545	24	complicated	complicated	JJ
cord-023168-cd7adns8	1546	1	malaria	malaria	NNP
cord-023168-cd7adns8	1547	1	The	the	DT
cord-023168-cd7adns8	1547	2	pathophysiology	pathophysiology	NN
cord-023168-cd7adns8	1547	3	of	of	IN
cord-023168-cd7adns8	1547	4	vivax	vivax	JJ
cord-023168-cd7adns8	1547	5	malaria	malaria	NN
cord-023168-cd7adns8	1547	6	Dynamic	dynamic	JJ
cord-023168-cd7adns8	1547	7	alteration	alteration	NN
cord-023168-cd7adns8	1547	8	in	in	IN
cord-023168-cd7adns8	1547	9	splenic	splenic	JJ
cord-023168-cd7adns8	1547	10	function	function	NN
cord-023168-cd7adns8	1547	11	during	during	IN
cord-023168-cd7adns8	1547	12	acute	acute	JJ
cord-023168-cd7adns8	1547	13	falciparum	falciparum	NN
cord-023168-cd7adns8	1547	14	malaria	malaria	NN
cord-023168-cd7adns8	1547	15	Resurgence	Resurgence	NNP
cord-023168-cd7adns8	1547	16	of	of	IN
cord-023168-cd7adns8	1547	17	blackwater	blackwater	NNP
cord-023168-cd7adns8	1547	18	fever	fever	NN
cord-023168-cd7adns8	1547	19	in	in	IN
cord-023168-cd7adns8	1547	20	long	long	JJ
cord-023168-cd7adns8	1547	21	-	-	HYPH
cord-023168-cd7adns8	1547	22	term	term	NN
cord-023168-cd7adns8	1547	23	European	european	JJ
cord-023168-cd7adns8	1547	24	expatriates	expatriate	NNS
cord-023168-cd7adns8	1547	25	in	in	IN
cord-023168-cd7adns8	1547	26	Africa	Africa	NNP
cord-023168-cd7adns8	1547	27	:	:	:
cord-023168-cd7adns8	1547	28	report	report	NN
cord-023168-cd7adns8	1547	29	of	of	IN
cord-023168-cd7adns8	1547	30	21	21	CD
cord-023168-cd7adns8	1547	31	cases	case	NNS
cord-023168-cd7adns8	1547	32	and	and	CC
cord-023168-cd7adns8	1547	33	review	review	VB
cord-023168-cd7adns8	1547	34	Glucose-6-phosphate	glucose-6-phosphate	NN
cord-023168-cd7adns8	1547	35	dehydrogenase	dehydrogenase	NN
cord-023168-cd7adns8	1547	36	(	(	-LRB-
cord-023168-cd7adns8	1547	37	G6PD	G6PD	NNP
cord-023168-cd7adns8	1547	38	)	)	-RRB-
cord-023168-cd7adns8	1547	39	mutations	mutation	NNS
cord-023168-cd7adns8	1547	40	and	and	CC
cord-023168-cd7adns8	1547	41	haemoglobinuria	haemoglobinuria	NNP
cord-023168-cd7adns8	1547	42	syndrome	syndrome	NN
cord-023168-cd7adns8	1547	43	in	in	IN
cord-023168-cd7adns8	1547	44	the	the	DT
cord-023168-cd7adns8	1547	45	Vietnamese	vietnamese	JJ
cord-023168-cd7adns8	1547	46	population	population	NN
cord-023168-cd7adns8	1547	47	Effect	effect	NN
cord-023168-cd7adns8	1547	48	of	of	IN
cord-023168-cd7adns8	1547	49	routine	routine	JJ
cord-023168-cd7adns8	1547	50	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	1547	51	supplementation	supplementation	NN
cord-023168-cd7adns8	1547	52	with	with	IN
cord-023168-cd7adns8	1547	53	iron	iron	NN
cord-023168-cd7adns8	1547	54	and	and	CC
cord-023168-cd7adns8	1547	55	folic	folic	JJ
cord-023168-cd7adns8	1547	56	acid	acid	NN
cord-023168-cd7adns8	1547	57	on	on	IN
cord-023168-cd7adns8	1547	58	admission	admission	NN
cord-023168-cd7adns8	1547	59	to	to	IN
cord-023168-cd7adns8	1547	60	hospital	hospital	NN
cord-023168-cd7adns8	1547	61	and	and	CC
cord-023168-cd7adns8	1547	62	mortality	mortality	NN
cord-023168-cd7adns8	1547	63	in	in	IN
cord-023168-cd7adns8	1547	64	preschool	preschool	NN
cord-023168-cd7adns8	1547	65	children	child	NNS
cord-023168-cd7adns8	1547	66	in	in	IN
cord-023168-cd7adns8	1547	67	a	a	DT
cord-023168-cd7adns8	1547	68	high	high	JJ
cord-023168-cd7adns8	1547	69	malaria	malaria	NN
cord-023168-cd7adns8	1547	70	transmission	transmission	NN
cord-023168-cd7adns8	1547	71	setting	setting	NN
cord-023168-cd7adns8	1547	72	:	:	:
cord-023168-cd7adns8	1547	73	a	a	DT
cord-023168-cd7adns8	1547	74	communitybased	communitybase	VBN
cord-023168-cd7adns8	1547	75	,	,	,
cord-023168-cd7adns8	1547	76	randomized	randomized	JJ
cord-023168-cd7adns8	1547	77	,	,	,
cord-023168-cd7adns8	1547	78	placebo	placebo	NN
cord-023168-cd7adns8	1547	79	-	-	HYPH
cord-023168-cd7adns8	1547	80	controlled	control	VBN
cord-023168-cd7adns8	1547	81	trial	trial	NN
cord-023168-cd7adns8	1547	82	Effect	effect	NN
cord-023168-cd7adns8	1547	83	of	of	IN
cord-023168-cd7adns8	1547	84	routine	routine	JJ
cord-023168-cd7adns8	1547	85	prophylactic	prophylactic	JJ
cord-023168-cd7adns8	1547	86	supplementation	supplementation	NN
cord-023168-cd7adns8	1547	87	with	with	IN
cord-023168-cd7adns8	1547	88	iron	iron	NN
cord-023168-cd7adns8	1547	89	and	and	CC
cord-023168-cd7adns8	1547	90	folic	folic	JJ
cord-023168-cd7adns8	1547	91	acid	acid	NN
cord-023168-cd7adns8	1547	92	on	on	IN
cord-023168-cd7adns8	1547	93	preschool	preschool	NN
cord-023168-cd7adns8	1547	94	child	child	NN
cord-023168-cd7adns8	1547	95	mortality	mortality	NN
cord-023168-cd7adns8	1547	96	in	in	IN
cord-023168-cd7adns8	1547	97	Southern	Southern	NNP
cord-023168-cd7adns8	1547	98	Nepal	Nepal	NNP
cord-023168-cd7adns8	1547	99	:	:	:
cord-023168-cd7adns8	1548	1	community	community	NN
cord-023168-cd7adns8	1548	2	based	base	VBN
cord-023168-cd7adns8	1548	3	,	,	,
cord-023168-cd7adns8	1548	4	clusterrandomised	clusterrandomise	VBN
cord-023168-cd7adns8	1548	5	,	,	,
cord-023168-cd7adns8	1548	6	placebo	placebo	NN
cord-023168-cd7adns8	1548	7	-	-	HYPH
cord-023168-cd7adns8	1548	8	controlled	control	VBN
cord-023168-cd7adns8	1548	9	trial	trial	NN
cord-023168-cd7adns8	1548	10	Oral	oral	JJ
cord-023168-cd7adns8	1548	11	iron	iron	NN
cord-023168-cd7adns8	1548	12	supplementation	supplementation	NN
cord-023168-cd7adns8	1548	13	for	for	IN
cord-023168-cd7adns8	1548	14	preventing	prevent	VBG
cord-023168-cd7adns8	1548	15	or	or	CC
cord-023168-cd7adns8	1548	16	treating	treat	VBG
cord-023168-cd7adns8	1548	17	anaemia	anaemia	NN
cord-023168-cd7adns8	1548	18	among	among	IN
cord-023168-cd7adns8	1548	19	children	child	NNS
cord-023168-cd7adns8	1548	20	in	in	IN
cord-023168-cd7adns8	1548	21	malaria	malaria	NN
cord-023168-cd7adns8	1548	22	-	-	HYPH
cord-023168-cd7adns8	1548	23	endemic	endemic	JJ
cord-023168-cd7adns8	1548	24	areas	area	NNS
cord-023168-cd7adns8	1548	25	Factors	factor	NNS
cord-023168-cd7adns8	1548	26	contributing	contribute	VBG
cord-023168-cd7adns8	1548	27	to	to	IN
cord-023168-cd7adns8	1548	28	anemia	anemia	NN
cord-023168-cd7adns8	1548	29	after	after	IN
cord-023168-cd7adns8	1548	30	uncomplicated	uncomplicated	JJ
cord-023168-cd7adns8	1548	31	falciparum	falciparum	NN
cord-023168-cd7adns8	1548	32	malaria	malaria	NN
cord-023168-cd7adns8	1548	33	Intermittent	intermittent	JJ
cord-023168-cd7adns8	1548	34	preventive	preventive	JJ
cord-023168-cd7adns8	1548	35	therapy	therapy	NN
cord-023168-cd7adns8	1548	36	for	for	IN
cord-023168-cd7adns8	1548	37	malaria	malaria	NN
cord-023168-cd7adns8	1548	38	with	with	IN
cord-023168-cd7adns8	1548	39	monthly	monthly	JJ
cord-023168-cd7adns8	1548	40	artemether	artemether	JJ
cord-023168-cd7adns8	1548	41	-	-	HYPH
cord-023168-cd7adns8	1548	42	lumefantrine	lumefantrine	NNP
cord-023168-cd7adns8	1548	43	for	for	IN
cord-023168-cd7adns8	1548	44	the	the	DT
cord-023168-cd7adns8	1548	45	postdischarge	postdischarge	NNP
cord-023168-cd7adns8	1548	46	management	management	NN
cord-023168-cd7adns8	1548	47	of	of	IN
cord-023168-cd7adns8	1548	48	severe	severe	JJ
cord-023168-cd7adns8	1548	49	anaemia	anaemia	NN
cord-023168-cd7adns8	1548	50	in	in	IN
cord-023168-cd7adns8	1548	51	children	child	NNS
cord-023168-cd7adns8	1548	52	aged	age	VBN
cord-023168-cd7adns8	1548	53	4	4	CD
cord-023168-cd7adns8	1548	54	-	-	SYM
cord-023168-cd7adns8	1548	55	59	59	CD
cord-023168-cd7adns8	1548	56	months	month	NNS
cord-023168-cd7adns8	1548	57	in	in	IN
cord-023168-cd7adns8	1548	58	southern	southern	JJ
cord-023168-cd7adns8	1548	59	Malawi	Malawi	NNP
cord-023168-cd7adns8	1548	60	:	:	:
cord-023168-cd7adns8	1548	61	a	a	DT
cord-023168-cd7adns8	1548	62	multicentre	multicentre	NNP
cord-023168-cd7adns8	1548	63	,	,	,
cord-023168-cd7adns8	1548	64	randomised	randomised	JJ
cord-023168-cd7adns8	1548	65	,	,	,
cord-023168-cd7adns8	1548	66	placebo	placebo	NN
cord-023168-cd7adns8	1548	67	-	-	HYPH
cord-023168-cd7adns8	1548	68	controlled	control	VBN
cord-023168-cd7adns8	1548	69	trial	trial	NN
cord-023168-cd7adns8	1548	70	Marked	mark	VBD
cord-023168-cd7adns8	1548	71	reduction	reduction	NN
cord-023168-cd7adns8	1548	72	in	in	IN
cord-023168-cd7adns8	1548	73	prevalence	prevalence	NN
cord-023168-cd7adns8	1548	74	of	of	IN
cord-023168-cd7adns8	1548	75	malaria	malaria	NN
cord-023168-cd7adns8	1548	76	parasitemia	parasitemia	NN
cord-023168-cd7adns8	1548	77	and	and	CC
cord-023168-cd7adns8	1548	78	anemia	anemia	NN
cord-023168-cd7adns8	1548	79	in	in	IN
cord-023168-cd7adns8	1548	80	HIV	HIV	NNP
cord-023168-cd7adns8	1548	81	-	-	HYPH
cord-023168-cd7adns8	1548	82	infected	infect	VBN
cord-023168-cd7adns8	1548	83	pregnant	pregnant	JJ
cord-023168-cd7adns8	1548	84	women	woman	NNS
cord-023168-cd7adns8	1548	85	taking	take	VBG
cord-023168-cd7adns8	1548	86	cotrimoxazole	cotrimoxazole	NN
cord-023168-cd7adns8	1548	87	with	with	IN
cord-023168-cd7adns8	1548	88	or	or	CC
cord-023168-cd7adns8	1548	89	without	without	IN
cord-023168-cd7adns8	1548	90	sulfadoxinepyrimethamine	sulfadoxinepyrimethamine	JJ
cord-023168-cd7adns8	1548	91	intermittent	intermittent	JJ
cord-023168-cd7adns8	1548	92	preventive	preventive	JJ
cord-023168-cd7adns8	1548	93	therapy	therapy	NN
cord-023168-cd7adns8	1548	94	during	during	IN
cord-023168-cd7adns8	1548	95	pregnancy	pregnancy	NN
cord-023168-cd7adns8	1548	96	in	in	IN
cord-023168-cd7adns8	1548	97	Malawi	Malawi	NNP
cord-023168-cd7adns8	1548	98	Platelet	Platelet	NNP
cord-023168-cd7adns8	1548	99	kinetics	kinetic	NNS
cord-023168-cd7adns8	1548	100	and	and	CC
cord-023168-cd7adns8	1548	101	scintigraphic	scintigraphic	JJ
cord-023168-cd7adns8	1548	102	imaging	imaging	NN
cord-023168-cd7adns8	1548	103	in	in	IN
cord-023168-cd7adns8	1548	104	thrombocytopenic	thrombocytopenic	JJ
cord-023168-cd7adns8	1548	105	malaria	malaria	NN
cord-023168-cd7adns8	1548	106	patients	patient	NNS
cord-023168-cd7adns8	1549	1	The	the	DT
cord-023168-cd7adns8	1549	2	role	role	NN
cord-023168-cd7adns8	1549	3	of	of	IN
cord-023168-cd7adns8	1549	4	platelets	platelet	NNS
cord-023168-cd7adns8	1549	5	in	in	IN
cord-023168-cd7adns8	1549	6	the	the	DT
cord-023168-cd7adns8	1549	7	pathogenesis	pathogenesis	NN
cord-023168-cd7adns8	1549	8	of	of	IN
cord-023168-cd7adns8	1549	9	cerebral	cerebral	JJ
cord-023168-cd7adns8	1549	10	malaria	malaria	NN
cord-023168-cd7adns8	1549	11	Erythrocytes	Erythrocytes	NNPS
cord-023168-cd7adns8	1549	12	infected	infect	VBN
cord-023168-cd7adns8	1549	13	by	by	IN
cord-023168-cd7adns8	1549	14	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1549	15	falciparum	falciparum	NN
cord-023168-cd7adns8	1549	16	activates	activate	VBZ
cord-023168-cd7adns8	1549	17	human	human	JJ
cord-023168-cd7adns8	1549	18	platelets	platelet	NNS
cord-023168-cd7adns8	1550	1	Plateletmediated	plateletmediated	JJ
cord-023168-cd7adns8	1550	2	clumping	clumping	NN
cord-023168-cd7adns8	1550	3	of	of	IN
cord-023168-cd7adns8	1550	4	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1550	5	falciparuminfected	falciparuminfecte	VBN
cord-023168-cd7adns8	1550	6	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1550	7	is	be	VBZ
cord-023168-cd7adns8	1550	8	a	a	DT
cord-023168-cd7adns8	1550	9	common	common	JJ
cord-023168-cd7adns8	1550	10	adhesive	adhesive	NN
cord-023168-cd7adns8	1550	11	phenotype	phenotype	NN
cord-023168-cd7adns8	1550	12	and	and	CC
cord-023168-cd7adns8	1550	13	is	be	VBZ
cord-023168-cd7adns8	1550	14	associated	associate	VBN
cord-023168-cd7adns8	1550	15	with	with	IN
cord-023168-cd7adns8	1550	16	severe	severe	JJ
cord-023168-cd7adns8	1550	17	malaria	malaria	NN
cord-023168-cd7adns8	1550	18	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1550	19	factor	factor	NN
cord-023168-cd7adns8	1550	20	propeptide	propeptide	NN
cord-023168-cd7adns8	1550	21	in	in	IN
cord-023168-cd7adns8	1550	22	malaria	malaria	NN
cord-023168-cd7adns8	1550	23	:	:	:
cord-023168-cd7adns8	1550	24	evidence	evidence	NN
cord-023168-cd7adns8	1550	25	of	of	IN
cord-023168-cd7adns8	1550	26	acute	acute	JJ
cord-023168-cd7adns8	1550	27	endothelial	endothelial	JJ
cord-023168-cd7adns8	1550	28	cell	cell	NN
cord-023168-cd7adns8	1550	29	activation	activation	NN
cord-023168-cd7adns8	1550	30	Thrombopoietin	Thrombopoietin	NNP
cord-023168-cd7adns8	1550	31	in	in	IN
cord-023168-cd7adns8	1550	32	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1550	33	falciparum	falciparum	NN
cord-023168-cd7adns8	1550	34	malaria	malaria	NN
cord-023168-cd7adns8	1550	35	Immunemediated	Immunemediated	NNP
cord-023168-cd7adns8	1550	36	thrombo	thrombo	NNP
cord-023168-cd7adns8	1550	37	-	-	HYPH
cord-023168-cd7adns8	1550	38	cytopenia	cytopenia	NNP
cord-023168-cd7adns8	1550	39	of	of	IN
cord-023168-cd7adns8	1550	40	malaria	malaria	NN
cord-023168-cd7adns8	1550	41	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	1550	42	in	in	IN
cord-023168-cd7adns8	1550	43	malaria	malaria	NN
cord-023168-cd7adns8	1550	44	:	:	:
cord-023168-cd7adns8	1550	45	who	who	WP
cord-023168-cd7adns8	1550	46	cares	care	VBZ
cord-023168-cd7adns8	1550	47	?	?	.
cord-023168-cd7adns8	1551	1	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	1551	2	in	in	IN
cord-023168-cd7adns8	1551	3	malaria	malaria	NN
cord-023168-cd7adns8	1552	1	Can	Can	MD
cord-023168-cd7adns8	1552	2	hematological	hematological	JJ
cord-023168-cd7adns8	1552	3	parameters	parameter	NNS
cord-023168-cd7adns8	1552	4	discriminate	discriminate	VBP
cord-023168-cd7adns8	1552	5	malaria	malaria	NN
cord-023168-cd7adns8	1552	6	from	from	IN
cord-023168-cd7adns8	1552	7	nonmalarious	nonmalarious	JJ
cord-023168-cd7adns8	1552	8	acute	acute	JJ
cord-023168-cd7adns8	1552	9	febrile	febrile	JJ
cord-023168-cd7adns8	1552	10	illness	illness	NN
cord-023168-cd7adns8	1552	11	in	in	IN
cord-023168-cd7adns8	1552	12	the	the	DT
cord-023168-cd7adns8	1552	13	tropics	tropic	NNS
cord-023168-cd7adns8	1552	14	?	?	.
cord-023168-cd7adns8	1553	1	Dysregulation	dysregulation	NN
cord-023168-cd7adns8	1553	2	of	of	IN
cord-023168-cd7adns8	1553	3	coagulation	coagulation	NN
cord-023168-cd7adns8	1553	4	in	in	IN
cord-023168-cd7adns8	1553	5	cerebral	cerebral	JJ
cord-023168-cd7adns8	1553	6	malaria	malaria	NN
cord-023168-cd7adns8	1554	1	The	the	DT
cord-023168-cd7adns8	1554	2	anatomic	anatomic	JJ
cord-023168-cd7adns8	1554	3	basis	basis	NN
cord-023168-cd7adns8	1554	4	of	of	IN
cord-023168-cd7adns8	1554	5	purpura	purpura	NN
cord-023168-cd7adns8	1554	6	Platelets	platelet	NNS
cord-023168-cd7adns8	1554	7	,	,	,
cord-023168-cd7adns8	1554	8	petechiae	petechia	NNS
cord-023168-cd7adns8	1554	9	,	,	,
cord-023168-cd7adns8	1554	10	and	and	CC
cord-023168-cd7adns8	1554	11	preservation	preservation	NN
cord-023168-cd7adns8	1554	12	of	of	IN
cord-023168-cd7adns8	1554	13	the	the	DT
cord-023168-cd7adns8	1554	14	vascular	vascular	JJ
cord-023168-cd7adns8	1554	15	wall	wall	NN
cord-023168-cd7adns8	1555	1	Plasmodium	plasmodium	NN
cord-023168-cd7adns8	1555	2	falciparum	falciparum	NN
cord-023168-cd7adns8	1555	3	infected	infect	VBN
cord-023168-cd7adns8	1555	4	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1555	5	induce	induce	VBP
cord-023168-cd7adns8	1555	6	tissue	tissue	NN
cord-023168-cd7adns8	1555	7	factor	factor	NN
cord-023168-cd7adns8	1555	8	expression	expression	NN
cord-023168-cd7adns8	1555	9	in	in	IN
cord-023168-cd7adns8	1555	10	endothelial	endothelial	JJ
cord-023168-cd7adns8	1555	11	cells	cell	NNS
cord-023168-cd7adns8	1555	12	and	and	CC
cord-023168-cd7adns8	1555	13	support	support	VBP
cord-023168-cd7adns8	1555	14	the	the	DT
cord-023168-cd7adns8	1555	15	assembly	assembly	NNP
cord-023168-cd7adns8	1555	16	of	of	IN
cord-023168-cd7adns8	1555	17	multimolecular	multimolecular	NNP
cord-023168-cd7adns8	1555	18	coagulation	coagulation	NN
cord-023168-cd7adns8	1555	19	complexes	complex	NNS
cord-023168-cd7adns8	1556	1	Monocyte	Monocyte	NNP
cord-023168-cd7adns8	1556	2	tissue	tissue	NN
cord-023168-cd7adns8	1556	3	factor	factor	NN
cord-023168-cd7adns8	1556	4	expression	expression	NN
cord-023168-cd7adns8	1556	5	induced	induce	VBN
cord-023168-cd7adns8	1556	6	by	by	IN
cord-023168-cd7adns8	1556	7	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1556	8	falciparum	falciparum	NN
cord-023168-cd7adns8	1556	9	-	-	HYPH
cord-023168-cd7adns8	1556	10	infected	infect	VBN
cord-023168-cd7adns8	1556	11	erythrocytes	erythrocyte	NNS
cord-023168-cd7adns8	1556	12	Blood	blood	NN
cord-023168-cd7adns8	1556	13	coagulation	coagulation	NN
cord-023168-cd7adns8	1556	14	,	,	,
cord-023168-cd7adns8	1556	15	inflammation	inflammation	NN
cord-023168-cd7adns8	1556	16	,	,	,
cord-023168-cd7adns8	1556	17	and	and	CC
cord-023168-cd7adns8	1556	18	malaria	malaria	NN
cord-023168-cd7adns8	1556	19	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	1556	20	and	and	CC
cord-023168-cd7adns8	1556	21	release	release	NN
cord-023168-cd7adns8	1556	22	of	of	IN
cord-023168-cd7adns8	1556	23	activated	activate	VBN
cord-023168-cd7adns8	1556	24	von	von	NNP
cord-023168-cd7adns8	1556	25	Willebrand	Willebrand	NNP
cord-023168-cd7adns8	1556	26	factor	factor	NN
cord-023168-cd7adns8	1556	27	during	during	IN
cord-023168-cd7adns8	1556	28	early	early	JJ
cord-023168-cd7adns8	1556	29	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1556	30	falciparum	falciparum	NN
cord-023168-cd7adns8	1557	1	malaria	malaria	NNP
cord-023168-cd7adns8	1557	2	Angiopoietin-2	Angiopoietin-2	NNP
cord-023168-cd7adns8	1557	3	is	be	VBZ
cord-023168-cd7adns8	1557	4	associated	associate	VBN
cord-023168-cd7adns8	1557	5	with	with	IN
cord-023168-cd7adns8	1557	6	decreased	decrease	VBN
cord-023168-cd7adns8	1557	7	endothelial	endothelial	JJ
cord-023168-cd7adns8	1557	8	nitric	nitric	NN
cord-023168-cd7adns8	1557	9	oxide	oxide	NN
cord-023168-cd7adns8	1557	10	and	and	CC
cord-023168-cd7adns8	1557	11	poor	poor	JJ
cord-023168-cd7adns8	1557	12	clinical	clinical	JJ
cord-023168-cd7adns8	1557	13	outcome	outcome	NN
cord-023168-cd7adns8	1557	14	in	in	IN
cord-023168-cd7adns8	1557	15	severe	severe	JJ
cord-023168-cd7adns8	1557	16	falciparum	falciparum	NN
cord-023168-cd7adns8	1557	17	malaria	malaria	NN
cord-023168-cd7adns8	1557	18	Elevated	elevated	JJ
cord-023168-cd7adns8	1557	19	thrombomodulin	thrombomodulin	NN
cord-023168-cd7adns8	1557	20	plasma	plasma	NN
cord-023168-cd7adns8	1557	21	levels	level	NNS
cord-023168-cd7adns8	1557	22	as	as	IN
cord-023168-cd7adns8	1557	23	a	a	DT
cord-023168-cd7adns8	1557	24	result	result	NN
cord-023168-cd7adns8	1557	25	of	of	IN
cord-023168-cd7adns8	1557	26	endothelial	endothelial	JJ
cord-023168-cd7adns8	1557	27	involvement	involvement	NN
cord-023168-cd7adns8	1557	28	in	in	IN
cord-023168-cd7adns8	1557	29	Plasmodium	Plasmodium	NNP
cord-023168-cd7adns8	1557	30	falciparum	falciparum	NN
cord-023168-cd7adns8	1557	31	malaria	malaria	NN
cord-023168-cd7adns8	1558	1	The	the	DT
cord-023168-cd7adns8	1558	2	pathogenic	pathogenic	JJ
cord-023168-cd7adns8	1558	3	basis	basis	NN
cord-023168-cd7adns8	1558	4	of	of	IN
cord-023168-cd7adns8	1558	5	malaria	malaria	NN
cord-023168-cd7adns8	1558	6	Differentiating	differentiate	VBG
cord-023168-cd7adns8	1558	7	the	the	DT
cord-023168-cd7adns8	1558	8	pathologies	pathology	NNS
cord-023168-cd7adns8	1558	9	of	of	IN
cord-023168-cd7adns8	1558	10	cerebral	cerebral	JJ
cord-023168-cd7adns8	1558	11	malaria	malaria	NN
cord-023168-cd7adns8	1558	12	by	by	IN
cord-023168-cd7adns8	1558	13	postmortem	postmortem	JJ
cord-023168-cd7adns8	1558	14	parasite	parasite	NN
cord-023168-cd7adns8	1558	15	counts	count	NNS
cord-023168-cd7adns8	1559	1	Fibrinolysis	Fibrinolysis	NNP
cord-023168-cd7adns8	1559	2	,	,	,
cord-023168-cd7adns8	1559	3	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1559	4	of	of	IN
cord-023168-cd7adns8	1559	5	blood	blood	NN
cord-023168-cd7adns8	1559	6	coagulation	coagulation	NN
cord-023168-cd7adns8	1559	7	,	,	,
cord-023168-cd7adns8	1559	8	and	and	CC
cord-023168-cd7adns8	1559	9	monocyte	monocyte	NNP
cord-023168-cd7adns8	1559	10	derived	derive	VBD
cord-023168-cd7adns8	1559	11	coagulant	coagulant	NN
cord-023168-cd7adns8	1559	12	activity	activity	NN
cord-023168-cd7adns8	1559	13	in	in	IN
cord-023168-cd7adns8	1559	14	acute	acute	JJ
cord-023168-cd7adns8	1559	15	malaria	malaria	NN
cord-023168-cd7adns8	1559	16	Epidemiology	epidemiology	NN
cord-023168-cd7adns8	1559	17	of	of	IN
cord-023168-cd7adns8	1559	18	anemia	anemia	NN
cord-023168-cd7adns8	1559	19	in	in	IN
cord-023168-cd7adns8	1559	20	human	human	JJ
cord-023168-cd7adns8	1559	21	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1559	22	virus	virus	NN
cord-023168-cd7adns8	1559	23	(	(	-LRB-
cord-023168-cd7adns8	1559	24	HIV)-infected	hiv)-infected	JJ
cord-023168-cd7adns8	1559	25	persons	person	NNS
cord-023168-cd7adns8	1559	26	:	:	:
cord-023168-cd7adns8	1559	27	results	result	NNS
cord-023168-cd7adns8	1559	28	from	from	IN
cord-023168-cd7adns8	1559	29	the	the	DT
cord-023168-cd7adns8	1559	30	multistate	multistate	JJ
cord-023168-cd7adns8	1559	31	adult	adult	NN
cord-023168-cd7adns8	1559	32	and	and	CC
cord-023168-cd7adns8	1559	33	adolescent	adolescent	JJ
cord-023168-cd7adns8	1559	34	spectrum	spectrum	NN
cord-023168-cd7adns8	1559	35	of	of	IN
cord-023168-cd7adns8	1559	36	HIV	HIV	NNP
cord-023168-cd7adns8	1559	37	disease	disease	NN
cord-023168-cd7adns8	1559	38	surveillance	surveillance	NN
cord-023168-cd7adns8	1559	39	project	project	NN
cord-023168-cd7adns8	1559	40	Impact	Impact	NNP
cord-023168-cd7adns8	1559	41	of	of	IN
cord-023168-cd7adns8	1559	42	highly	highly	RB
cord-023168-cd7adns8	1559	43	active	active	JJ
cord-023168-cd7adns8	1559	44	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1559	45	therapy	therapy	NN
cord-023168-cd7adns8	1559	46	on	on	IN
cord-023168-cd7adns8	1559	47	anemia	anemia	NN
cord-023168-cd7adns8	1559	48	and	and	CC
cord-023168-cd7adns8	1559	49	relationship	relationship	NN
cord-023168-cd7adns8	1559	50	between	between	IN
cord-023168-cd7adns8	1559	51	anemia	anemia	NN
cord-023168-cd7adns8	1559	52	and	and	CC
cord-023168-cd7adns8	1559	53	survival	survival	NN
cord-023168-cd7adns8	1559	54	in	in	IN
cord-023168-cd7adns8	1559	55	a	a	DT
cord-023168-cd7adns8	1559	56	large	large	JJ
cord-023168-cd7adns8	1559	57	cohort	cohort	NN
cord-023168-cd7adns8	1559	58	of	of	IN
cord-023168-cd7adns8	1559	59	HIV	HIV	NNP
cord-023168-cd7adns8	1559	60	-	-	HYPH
cord-023168-cd7adns8	1559	61	infected	infect	VBN
cord-023168-cd7adns8	1559	62	women	woman	NNS
cord-023168-cd7adns8	1560	1	:	:	:
cord-023168-cd7adns8	1560	2	Women	Women	NNP
cord-023168-cd7adns8	1560	3	's	's	POS
cord-023168-cd7adns8	1560	4	Interagency	Interagency	NNP
cord-023168-cd7adns8	1560	5	HIV	HIV	NNP
cord-023168-cd7adns8	1560	6	Study	Study	NNP
cord-023168-cd7adns8	1560	7	Anemia	Anemia	NNP
cord-023168-cd7adns8	1560	8	is	be	VBZ
cord-023168-cd7adns8	1560	9	an	an	DT
cord-023168-cd7adns8	1560	10	independent	independent	JJ
cord-023168-cd7adns8	1560	11	predictor	predictor	NN
cord-023168-cd7adns8	1560	12	of	of	IN
cord-023168-cd7adns8	1560	13	mortality	mortality	NN
cord-023168-cd7adns8	1560	14	and	and	CC
cord-023168-cd7adns8	1560	15	immunologic	immunologic	JJ
cord-023168-cd7adns8	1560	16	progression	progression	NN
cord-023168-cd7adns8	1560	17	of	of	IN
cord-023168-cd7adns8	1560	18	disease	disease	NN
cord-023168-cd7adns8	1560	19	among	among	IN
cord-023168-cd7adns8	1560	20	women	woman	NNS
cord-023168-cd7adns8	1560	21	with	with	IN
cord-023168-cd7adns8	1560	22	HIV	HIV	NNP
cord-023168-cd7adns8	1560	23	in	in	IN
cord-023168-cd7adns8	1560	24	Tanzania	Tanzania	NNP
cord-023168-cd7adns8	1560	25	Human	Human	NNP
cord-023168-cd7adns8	1560	26	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1560	27	virus	virus	NN
cord-023168-cd7adns8	1560	28	hematology	hematology	NN
cord-023168-cd7adns8	1560	29	Prevalence	prevalence	NN
cord-023168-cd7adns8	1560	30	of	of	IN
cord-023168-cd7adns8	1560	31	parvovirus	parvovirus	NN
cord-023168-cd7adns8	1560	32	B19	B19	NNP
cord-023168-cd7adns8	1560	33	infection	infection	NN
cord-023168-cd7adns8	1560	34	in	in	IN
cord-023168-cd7adns8	1560	35	patients	patient	NNS
cord-023168-cd7adns8	1560	36	infected	infect	VBN
cord-023168-cd7adns8	1560	37	with	with	IN
cord-023168-cd7adns8	1560	38	human	human	JJ
cord-023168-cd7adns8	1560	39	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1560	40	virus	virus	NN
cord-023168-cd7adns8	1560	41	Clinical	clinical	JJ
cord-023168-cd7adns8	1560	42	relevance	relevance	NN
cord-023168-cd7adns8	1560	43	of	of	IN
cord-023168-cd7adns8	1560	44	parvovirus	parvovirus	NN
cord-023168-cd7adns8	1560	45	B19	B19	NNP
cord-023168-cd7adns8	1560	46	as	as	IN
cord-023168-cd7adns8	1560	47	a	a	DT
cord-023168-cd7adns8	1560	48	cause	cause	NN
cord-023168-cd7adns8	1560	49	of	of	IN
cord-023168-cd7adns8	1560	50	anemia	anemia	NN
cord-023168-cd7adns8	1560	51	in	in	IN
cord-023168-cd7adns8	1560	52	patients	patient	NNS
cord-023168-cd7adns8	1560	53	with	with	IN
cord-023168-cd7adns8	1560	54	human	human	JJ
cord-023168-cd7adns8	1560	55	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1560	56	virus	virus	NN
cord-023168-cd7adns8	1560	57	infection	infection	NN
cord-023168-cd7adns8	1560	58	Erythropoiesis	Erythropoiesis	NNP
cord-023168-cd7adns8	1560	59	in	in	IN
cord-023168-cd7adns8	1560	60	HIV	HIV	NNP
cord-023168-cd7adns8	1560	61	-	-	HYPH
cord-023168-cd7adns8	1560	62	infected	infect	VBN
cord-023168-cd7adns8	1560	63	and	and	CC
cord-023168-cd7adns8	1560	64	uninfected	uninfected	JJ
cord-023168-cd7adns8	1560	65	Malawian	malawian	JJ
cord-023168-cd7adns8	1560	66	children	child	NNS
cord-023168-cd7adns8	1560	67	with	with	IN
cord-023168-cd7adns8	1560	68	severe	severe	JJ
cord-023168-cd7adns8	1560	69	anemia	anemia	NN
cord-023168-cd7adns8	1560	70	Anemia	anemia	NN
cord-023168-cd7adns8	1560	71	in	in	IN
cord-023168-cd7adns8	1560	72	HIV	HIV	NNP
cord-023168-cd7adns8	1560	73	-	-	HYPH
cord-023168-cd7adns8	1560	74	infected	infect	VBN
cord-023168-cd7adns8	1560	75	patients	patient	NNS
cord-023168-cd7adns8	1560	76	receiving	receive	VBG
cord-023168-cd7adns8	1560	77	highly	highly	RB
cord-023168-cd7adns8	1560	78	active	active	JJ
cord-023168-cd7adns8	1560	79	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1560	80	therapy	therapy	NN
cord-023168-cd7adns8	1560	81	Fatal	Fatal	NNP
cord-023168-cd7adns8	1560	82	disseminated	disseminate	VBD
cord-023168-cd7adns8	1560	83	intravascular	intravascular	JJ
cord-023168-cd7adns8	1560	84	coagulation	coagulation	NN
cord-023168-cd7adns8	1560	85	and	and	CC
cord-023168-cd7adns8	1560	86	pulmonary	pulmonary	JJ
cord-023168-cd7adns8	1560	87	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1560	88	following	follow	VBG
cord-023168-cd7adns8	1560	89	blood	blood	NN
cord-023168-cd7adns8	1560	90	transfusion	transfusion	NN
cord-023168-cd7adns8	1560	91	in	in	IN
cord-023168-cd7adns8	1560	92	a	a	DT
cord-023168-cd7adns8	1560	93	patient	patient	NN
cord-023168-cd7adns8	1560	94	with	with	IN
cord-023168-cd7adns8	1560	95	severe	severe	JJ
cord-023168-cd7adns8	1560	96	autoimmune	autoimmune	JJ
cord-023168-cd7adns8	1560	97	haemolytic	haemolytic	JJ
cord-023168-cd7adns8	1560	98	anemia	anemia	NN
cord-023168-cd7adns8	1560	99	and	and	CC
cord-023168-cd7adns8	1560	100	human	human	JJ
cord-023168-cd7adns8	1560	101	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1560	102	virus	virus	NN
cord-023168-cd7adns8	1560	103	infection	infection	NN
cord-023168-cd7adns8	1560	104	Epoetin	Epoetin	NNP
cord-023168-cd7adns8	1560	105	alfa	alfa	NNP
cord-023168-cd7adns8	1560	106	for	for	IN
cord-023168-cd7adns8	1560	107	treatment	treatment	NN
cord-023168-cd7adns8	1560	108	of	of	IN
cord-023168-cd7adns8	1560	109	anemia	anemia	NN
cord-023168-cd7adns8	1560	110	in	in	IN
cord-023168-cd7adns8	1560	111	HIV	HIV	NNP
cord-023168-cd7adns8	1560	112	-	-	HYPH
cord-023168-cd7adns8	1560	113	infected	infect	VBN
cord-023168-cd7adns8	1560	114	patients	patient	NNS
cord-023168-cd7adns8	1560	115	:	:	:
cord-023168-cd7adns8	1560	116	past	past	JJ
cord-023168-cd7adns8	1560	117	,	,	,
cord-023168-cd7adns8	1560	118	present	present	JJ
cord-023168-cd7adns8	1560	119	,	,	,
cord-023168-cd7adns8	1560	120	and	and	CC
cord-023168-cd7adns8	1560	121	future	future	JJ
cord-023168-cd7adns8	1560	122	Once	once	RB
cord-023168-cd7adns8	1560	123	-	-	HYPH
cord-023168-cd7adns8	1560	124	weekly	weekly	JJ
cord-023168-cd7adns8	1560	125	epoetinalfa	epoetinalfa	NNP
cord-023168-cd7adns8	1560	126	improves	improve	VBZ
cord-023168-cd7adns8	1560	127	quality	quality	NN
cord-023168-cd7adns8	1560	128	of	of	IN
cord-023168-cd7adns8	1560	129	life	life	NN
cord-023168-cd7adns8	1560	130	and	and	CC
cord-023168-cd7adns8	1560	131	increases	increase	VBZ
cord-023168-cd7adns8	1560	132	hemoglobin	hemoglobin	NN
cord-023168-cd7adns8	1560	133	in	in	IN
cord-023168-cd7adns8	1560	134	anemic	anemic	JJ
cord-023168-cd7adns8	1560	135	HIV+	HIV+	NNP
cord-023168-cd7adns8	1560	136	patients	patient	NNS
cord-023168-cd7adns8	1560	137	Epidemiology	Epidemiology	NNP
cord-023168-cd7adns8	1560	138	of	of	IN
cord-023168-cd7adns8	1560	139	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1560	140	in	in	IN
cord-023168-cd7adns8	1560	141	HIV	HIV	NNP
cord-023168-cd7adns8	1560	142	infection	infection	NN
cord-023168-cd7adns8	1560	143	Surveillance	surveillance	NN
cord-023168-cd7adns8	1560	144	for	for	IN
cord-023168-cd7adns8	1560	145	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1560	146	in	in	IN
cord-023168-cd7adns8	1560	147	persons	person	NNS
cord-023168-cd7adns8	1560	148	infected	infect	VBN
cord-023168-cd7adns8	1560	149	with	with	IN
cord-023168-cd7adns8	1560	150	HIV	HIV	NNP
cord-023168-cd7adns8	1560	151	:	:	:
cord-023168-cd7adns8	1560	152	Results	result	NNS
cord-023168-cd7adns8	1560	153	from	from	IN
cord-023168-cd7adns8	1560	154	the	the	DT
cord-023168-cd7adns8	1560	155	multistate	multistate	JJ
cord-023168-cd7adns8	1560	156	Adult	Adult	NNP
cord-023168-cd7adns8	1560	157	and	and	CC
cord-023168-cd7adns8	1560	158	Adolescent	Adolescent	NNP
cord-023168-cd7adns8	1560	159	Spectrum	Spectrum	NNP
cord-023168-cd7adns8	1560	160	of	of	IN
cord-023168-cd7adns8	1560	161	Disease	Disease	NNP
cord-023168-cd7adns8	1560	162	Project	Project	NNP
cord-023168-cd7adns8	1561	1	An	an	DT
cord-023168-cd7adns8	1561	2	Overview	Overview	NNP
cord-023168-cd7adns8	1561	3	of	of	IN
cord-023168-cd7adns8	1561	4	the	the	DT
cord-023168-cd7adns8	1561	5	Mechanisms	Mechanisms	NNPS
cord-023168-cd7adns8	1561	6	of	of	IN
cord-023168-cd7adns8	1561	7	HIV	HIV	NNP
cord-023168-cd7adns8	1561	8	-	-	HYPH
cord-023168-cd7adns8	1561	9	Related	relate	VBN
cord-023168-cd7adns8	1561	10	Thrombocytopenia	Thrombocytopenia	NNP
cord-023168-cd7adns8	1561	11	Role	role	NN
cord-023168-cd7adns8	1561	12	of	of	IN
cord-023168-cd7adns8	1561	13	molecular	molecular	JJ
cord-023168-cd7adns8	1561	14	mimicry	mimicry	NN
cord-023168-cd7adns8	1561	15	to	to	IN
cord-023168-cd7adns8	1561	16	HIV-1	HIV-1	NNP
cord-023168-cd7adns8	1561	17	peptides	peptide	NNS
cord-023168-cd7adns8	1561	18	in	in	IN
cord-023168-cd7adns8	1561	19	HIV-1	HIV-1	NNP
cord-023168-cd7adns8	1561	20	related	relate	VBD
cord-023168-cd7adns8	1561	21	immunologic	immunologic	JJ
cord-023168-cd7adns8	1561	22	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1561	23	Complement	complement	NN
cord-023168-cd7adns8	1561	24	-	-	HYPH
cord-023168-cd7adns8	1561	25	independent	independent	JJ
cord-023168-cd7adns8	1561	26	,	,	,
cord-023168-cd7adns8	1561	27	peroxide	peroxide	NN
cord-023168-cd7adns8	1561	28	induced	induce	VBN
cord-023168-cd7adns8	1561	29	antibody	antibody	NN
cord-023168-cd7adns8	1561	30	lysis	lysis	NN
cord-023168-cd7adns8	1561	31	of	of	IN
cord-023168-cd7adns8	1561	32	platelets	platelet	NNS
cord-023168-cd7adns8	1561	33	in	in	IN
cord-023168-cd7adns8	1561	34	HIV-1	HIV-1	NNP
cord-023168-cd7adns8	1561	35	related	relate	VBD
cord-023168-cd7adns8	1561	36	immune	immune	JJ
cord-023168-cd7adns8	1561	37	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1561	38	Ineffective	ineffective	JJ
cord-023168-cd7adns8	1561	39	platelet	platelet	NN
cord-023168-cd7adns8	1561	40	production	production	NN
cord-023168-cd7adns8	1561	41	in	in	IN
cord-023168-cd7adns8	1561	42	thrombocytopenic	thrombocytopenic	JJ
cord-023168-cd7adns8	1561	43	human	human	JJ
cord-023168-cd7adns8	1561	44	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1561	45	virus	virus	NN
cord-023168-cd7adns8	1561	46	-	-	HYPH
cord-023168-cd7adns8	1561	47	infected	infect	VBN
cord-023168-cd7adns8	1561	48	patients	patient	NNS
cord-023168-cd7adns8	1561	49	Effect	Effect	NNP
cord-023168-cd7adns8	1561	50	of	of	IN
cord-023168-cd7adns8	1561	51	highly	highly	RB
cord-023168-cd7adns8	1561	52	active	active	JJ
cord-023168-cd7adns8	1561	53	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1561	54	therapy	therapy	NN
cord-023168-cd7adns8	1561	55	on	on	IN
cord-023168-cd7adns8	1561	56	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1561	57	in	in	IN
cord-023168-cd7adns8	1561	58	patients	patient	NNS
cord-023168-cd7adns8	1561	59	with	with	IN
cord-023168-cd7adns8	1561	60	HIV	HIV	NNP
cord-023168-cd7adns8	1561	61	infection	infection	NN
cord-023168-cd7adns8	1561	62	Response	response	NN
cord-023168-cd7adns8	1561	63	of	of	IN
cord-023168-cd7adns8	1561	64	severe	severe	JJ
cord-023168-cd7adns8	1561	65	HIV	HIV	NNP
cord-023168-cd7adns8	1561	66	-	-	HYPH
cord-023168-cd7adns8	1561	67	associated	associate	VBN
cord-023168-cd7adns8	1561	68	thrombocytopenia	thrombocytopenia	NN
cord-023168-cd7adns8	1561	69	to	to	IN
cord-023168-cd7adns8	1561	70	highly	highly	RB
cord-023168-cd7adns8	1561	71	active	active	JJ
cord-023168-cd7adns8	1561	72	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1561	73	therapy	therapy	NN
cord-023168-cd7adns8	1561	74	including	include	VBG
cord-023168-cd7adns8	1561	75	protease	protease	NN
cord-023168-cd7adns8	1561	76	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1561	77	Human	human	JJ
cord-023168-cd7adns8	1561	78	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1561	79	virus	virus	NN
cord-023168-cd7adns8	1561	80	associated	associate	VBN
cord-023168-cd7adns8	1562	1	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1562	2	thrombocytopenic	thrombocytopenic	JJ
cord-023168-cd7adns8	1562	3	purpura	purpura	NN
cord-023168-cd7adns8	1562	4	-favourable	-favourable	JJ
cord-023168-cd7adns8	1562	5	outcome	outcome	NN
cord-023168-cd7adns8	1562	6	with	with	IN
cord-023168-cd7adns8	1562	7	plasma	plasma	NN
cord-023168-cd7adns8	1562	8	exchange	exchange	NN
cord-023168-cd7adns8	1562	9	and	and	CC
cord-023168-cd7adns8	1562	10	prompt	prompt	JJ
cord-023168-cd7adns8	1562	11	initiation	initiation	NN
cord-023168-cd7adns8	1562	12	of	of	IN
cord-023168-cd7adns8	1562	13	highly	highly	RB
cord-023168-cd7adns8	1562	14	active	active	JJ
cord-023168-cd7adns8	1562	15	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1562	16	therapy	therapy	NN
cord-023168-cd7adns8	1563	1	Is	be	VBZ
cord-023168-cd7adns8	1563	2	it	-PRON-	PRP
cord-023168-cd7adns8	1563	3	HIV	HIV	NNP
cord-023168-cd7adns8	1563	4	TTP	TTP	NNP
cord-023168-cd7adns8	1563	5	or	or	CC
cord-023168-cd7adns8	1563	6	HIV	HIV	NNP
cord-023168-cd7adns8	1563	7	-	-	HYPH
cord-023168-cd7adns8	1563	8	associated	associate	VBN
cord-023168-cd7adns8	1563	9	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1563	10	microangiopathy	microangiopathy	NN
cord-023168-cd7adns8	1563	11	?	?	.
cord-023168-cd7adns8	1564	1	ADAMTS13	ADAMTS13	NNP
cord-023168-cd7adns8	1564	2	activity	activity	NN
cord-023168-cd7adns8	1564	3	and	and	CC
cord-023168-cd7adns8	1564	4	the	the	DT
cord-023168-cd7adns8	1564	5	presence	presence	NN
cord-023168-cd7adns8	1564	6	of	of	IN
cord-023168-cd7adns8	1564	7	acquired	acquire	VBN
cord-023168-cd7adns8	1564	8	inhibitors	inhibitor	NNS
cord-023168-cd7adns8	1564	9	in	in	IN
cord-023168-cd7adns8	1564	10	human	human	JJ
cord-023168-cd7adns8	1564	11	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1564	12	virus	virus	NN
cord-023168-cd7adns8	1564	13	-	-	HYPH
cord-023168-cd7adns8	1564	14	related	relate	VBN
cord-023168-cd7adns8	1564	15	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1564	16	thrombocytopenic	thrombocytopenic	JJ
cord-023168-cd7adns8	1564	17	purpura	purpura	NN
cord-023168-cd7adns8	1564	18	Thrombotic	Thrombotic	NNP
cord-023168-cd7adns8	1564	19	microangiopathy	microangiopathy	NN
cord-023168-cd7adns8	1564	20	in	in	IN
cord-023168-cd7adns8	1564	21	patients	patient	NNS
cord-023168-cd7adns8	1564	22	with	with	IN
cord-023168-cd7adns8	1564	23	acquired	acquire	VBN
cord-023168-cd7adns8	1564	24	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1564	25	syndrome	syndrome	NN
cord-023168-cd7adns8	1564	26	before	before	IN
cord-023168-cd7adns8	1564	27	and	and	CC
cord-023168-cd7adns8	1564	28	during	during	IN
cord-023168-cd7adns8	1564	29	the	the	DT
cord-023168-cd7adns8	1564	30	era	era	NN
cord-023168-cd7adns8	1564	31	of	of	IN
cord-023168-cd7adns8	1564	32	introduction	introduction	NN
cord-023168-cd7adns8	1564	33	of	of	IN
cord-023168-cd7adns8	1564	34	highly	highly	RB
cord-023168-cd7adns8	1564	35	active	active	JJ
cord-023168-cd7adns8	1564	36	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1564	37	therapy	therapy	NN
cord-023168-cd7adns8	1564	38	Collaborations	collaboration	NNS
cord-023168-cd7adns8	1564	39	in	in	IN
cord-023168-cd7adns8	1564	40	HIV	HIV	NNP
cord-023168-cd7adns8	1564	41	Outcomes	Outcomes	NNP
cord-023168-cd7adns8	1564	42	Research	Research	NNP
cord-023168-cd7adns8	1564	43	/	/	SYM
cord-023168-cd7adns8	1564	44	US	US	NNP
cord-023168-cd7adns8	1564	45	Cohort	Cohort	NNP
cord-023168-cd7adns8	1564	46	.	.	.
cord-023168-cd7adns8	1565	1	HIVassociated	HIVassociated	NNP
cord-023168-cd7adns8	1565	2	thrombotic	thrombotic	JJ
cord-023168-cd7adns8	1565	3	microangiopathy	microangiopathy	NNP
cord-023168-cd7adns8	1565	4	in	in	IN
cord-023168-cd7adns8	1565	5	the	the	DT
cord-023168-cd7adns8	1565	6	era	era	NN
cord-023168-cd7adns8	1565	7	of	of	IN
cord-023168-cd7adns8	1565	8	highly	highly	RB
cord-023168-cd7adns8	1565	9	active	active	JJ
cord-023168-cd7adns8	1565	10	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1565	11	therapy	therapy	NN
cord-023168-cd7adns8	1565	12	:	:	:
cord-023168-cd7adns8	1566	1	an	an	DT
cord-023168-cd7adns8	1566	2	observational	observational	JJ
cord-023168-cd7adns8	1566	3	study	study	NN
cord-023168-cd7adns8	1566	4	AIDSassociated	aidsassociate	VBN
cord-023168-cd7adns8	1567	1	non	non	JJ
cord-023168-cd7adns8	1567	2	-	-	JJ
cord-023168-cd7adns8	1567	3	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1567	4	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1567	5	Prognosis	prognosis	NN
cord-023168-cd7adns8	1567	6	of	of	IN
cord-023168-cd7adns8	1567	7	HIV	HIV	NNP
cord-023168-cd7adns8	1567	8	-	-	HYPH
cord-023168-cd7adns8	1567	9	associated	associate	VBN
cord-023168-cd7adns8	1567	10	non	non	NNP
cord-023168-cd7adns8	1567	11	-	-	JJ
cord-023168-cd7adns8	1567	12	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1567	13	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1567	14	in	in	IN
cord-023168-cd7adns8	1567	15	patients	patient	NNS
cord-023168-cd7adns8	1567	16	starting	start	VBG
cord-023168-cd7adns8	1567	17	combination	combination	NN
cord-023168-cd7adns8	1567	18	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1567	19	therapy	therapy	NN
cord-023168-cd7adns8	1567	20	Therapeutic	therapeutic	JJ
cord-023168-cd7adns8	1567	21	options	option	NNS
cord-023168-cd7adns8	1567	22	for	for	IN
cord-023168-cd7adns8	1567	23	HIV	HIV	NNP
cord-023168-cd7adns8	1567	24	-	-	HYPH
cord-023168-cd7adns8	1567	25	associated	associate	VBN
cord-023168-cd7adns8	1567	26	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1567	27	Changes	change	NNS
cord-023168-cd7adns8	1567	28	in	in	IN
cord-023168-cd7adns8	1567	29	AIDS	AIDS	NNP
cord-023168-cd7adns8	1567	30	-	-	HYPH
cord-023168-cd7adns8	1567	31	related	relate	VBN
cord-023168-cd7adns8	1567	32	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1567	33	since	since	IN
cord-023168-cd7adns8	1567	34	the	the	DT
cord-023168-cd7adns8	1567	35	era	era	NN
cord-023168-cd7adns8	1567	36	of	of	IN
cord-023168-cd7adns8	1567	37	highly	highly	RB
cord-023168-cd7adns8	1567	38	active	active	JJ
cord-023168-cd7adns8	1567	39	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1567	40	therapy	therapy	NN
cord-023168-cd7adns8	1567	41	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1567	42	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1567	43	and	and	CC
cord-023168-cd7adns8	1567	44	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1567	45	in	in	IN
cord-023168-cd7adns8	1567	46	persons	person	NNS
cord-023168-cd7adns8	1567	47	with	with	IN
cord-023168-cd7adns8	1567	48	HIV	HIV	NNP
cord-023168-cd7adns8	1567	49	/	/	SYM
cord-023168-cd7adns8	1567	50	AIDS	AIDS	NNP
cord-023168-cd7adns8	1568	1	Why	why	WRB
cord-023168-cd7adns8	1568	2	would	would	MD
cord-023168-cd7adns8	1568	3	the	the	DT
cord-023168-cd7adns8	1568	4	incidence	incidence	NN
cord-023168-cd7adns8	1568	5	of	of	IN
cord-023168-cd7adns8	1568	6	HIV	HIV	NNP
cord-023168-cd7adns8	1568	7	-	-	HYPH
cord-023168-cd7adns8	1568	8	associated	associate	VBN
cord-023168-cd7adns8	1568	9	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1568	10	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1568	11	increase	increase	NN
cord-023168-cd7adns8	1568	12	in	in	IN
cord-023168-cd7adns8	1568	13	the	the	DT
cord-023168-cd7adns8	1568	14	setting	setting	NN
cord-023168-cd7adns8	1568	15	of	of	IN
cord-023168-cd7adns8	1568	16	improved	improve	VBN
cord-023168-cd7adns8	1568	17	immunity	immunity	NN
cord-023168-cd7adns8	1568	18	?	?	.
cord-023168-cd7adns8	1569	1	Dynamics	dynamic	NNS
cord-023168-cd7adns8	1569	2	of	of	IN
cord-023168-cd7adns8	1569	3	Epstein	Epstein	NNP
cord-023168-cd7adns8	1569	4	-	-	HYPH
cord-023168-cd7adns8	1569	5	Barr	Barr	NNP
cord-023168-cd7adns8	1569	6	virus	virus	NN
cord-023168-cd7adns8	1569	7	in	in	IN
cord-023168-cd7adns8	1569	8	HIV-1-infected	hiv-1-infecte	VBN
cord-023168-cd7adns8	1569	9	subjects	subject	NNS
cord-023168-cd7adns8	1569	10	on	on	IN
cord-023168-cd7adns8	1569	11	highly	highly	RB
cord-023168-cd7adns8	1569	12	active	active	JJ
cord-023168-cd7adns8	1569	13	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1569	14	therapy	therapy	NN
cord-023168-cd7adns8	1569	15	World	World	NNP
cord-023168-cd7adns8	1569	16	Health	Health	NNP
cord-023168-cd7adns8	1569	17	Organization	Organization	NNP
cord-023168-cd7adns8	1569	18	classification	classification	NN
cord-023168-cd7adns8	1569	19	of	of	IN
cord-023168-cd7adns8	1569	20	tumours	tumour	NNS
cord-023168-cd7adns8	1569	21	,	,	,
cord-023168-cd7adns8	1569	22	pathology	pathology	NN
cord-023168-cd7adns8	1569	23	and	and	CC
cord-023168-cd7adns8	1569	24	genetics	genetic	NNS
cord-023168-cd7adns8	1569	25	of	of	IN
cord-023168-cd7adns8	1569	26	tumours	tumour	NNS
cord-023168-cd7adns8	1569	27	of	of	IN
cord-023168-cd7adns8	1569	28	haematopoietic	haematopoietic	JJ
cord-023168-cd7adns8	1569	29	and	and	CC
cord-023168-cd7adns8	1569	30	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1569	31	tissues	tissue	NNS
cord-023168-cd7adns8	1569	32	Characterization	characterization	NN
cord-023168-cd7adns8	1569	33	of	of	IN
cord-023168-cd7adns8	1569	34	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1569	35	in	in	IN
cord-023168-cd7adns8	1569	36	a	a	DT
cord-023168-cd7adns8	1569	37	high	high	JJ
cord-023168-cd7adns8	1569	38	prevalence	prevalence	NN
cord-023168-cd7adns8	1569	39	HIV	HIV	NNP
cord-023168-cd7adns8	1569	40	setting	set	VBG
cord-023168-cd7adns8	1569	41	Acquired	acquire	VBN
cord-023168-cd7adns8	1569	42	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1569	43	syndrome	syndrome	NN
cord-023168-cd7adns8	1569	44	-	-	HYPH
cord-023168-cd7adns8	1569	45	related	relate	VBN
cord-023168-cd7adns8	1569	46	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1569	47	AIDS	AIDS	NNP
cord-023168-cd7adns8	1569	48	primary	primary	JJ
cord-023168-cd7adns8	1569	49	central	central	JJ
cord-023168-cd7adns8	1569	50	nervous	nervous	JJ
cord-023168-cd7adns8	1569	51	system	system	NN
cord-023168-cd7adns8	1569	52	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1569	53	Improvement	improvement	NN
cord-023168-cd7adns8	1569	54	of	of	IN
cord-023168-cd7adns8	1569	55	systemic	systemic	JJ
cord-023168-cd7adns8	1569	56	human	human	JJ
cord-023168-cd7adns8	1569	57	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1569	58	virus	virus	NN
cord-023168-cd7adns8	1569	59	-	-	HYPH
cord-023168-cd7adns8	1569	60	related	relate	VBN
cord-023168-cd7adns8	1569	61	non	non	JJ
cord-023168-cd7adns8	1569	62	-	-	JJ
cord-023168-cd7adns8	1569	63	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1569	64	's	's	POS
cord-023168-cd7adns8	1569	65	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1569	66	outcome	outcome	NN
cord-023168-cd7adns8	1569	67	in	in	IN
cord-023168-cd7adns8	1569	68	the	the	DT
cord-023168-cd7adns8	1569	69	era	era	NN
cord-023168-cd7adns8	1569	70	of	of	IN
cord-023168-cd7adns8	1569	71	highly	highly	RB
cord-023168-cd7adns8	1569	72	active	active	JJ
cord-023168-cd7adns8	1569	73	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1569	74	therapy	therapy	NN
cord-023168-cd7adns8	1569	75	Incidence	incidence	NN
cord-023168-cd7adns8	1569	76	and	and	CC
cord-023168-cd7adns8	1569	77	outcomes	outcome	NNS
cord-023168-cd7adns8	1569	78	of	of	IN
cord-023168-cd7adns8	1569	79	malignancy	malignancy	NN
cord-023168-cd7adns8	1569	80	in	in	IN
cord-023168-cd7adns8	1569	81	the	the	DT
cord-023168-cd7adns8	1569	82	HAART	HAART	NNP
cord-023168-cd7adns8	1569	83	era	era	NN
cord-023168-cd7adns8	1569	84	in	in	IN
cord-023168-cd7adns8	1569	85	an	an	DT
cord-023168-cd7adns8	1569	86	urban	urban	JJ
cord-023168-cd7adns8	1569	87	cohort	cohort	NN
cord-023168-cd7adns8	1569	88	of	of	IN
cord-023168-cd7adns8	1569	89	HIV	HIV	NNP
cord-023168-cd7adns8	1569	90	-	-	HYPH
cord-023168-cd7adns8	1569	91	infected	infect	VBN
cord-023168-cd7adns8	1569	92	individuals	individual	NNS
cord-023168-cd7adns8	1570	1	Evolving	evolve	VBG
cord-023168-cd7adns8	1570	2	characteristics	characteristic	NNS
cord-023168-cd7adns8	1570	3	of	of	IN
cord-023168-cd7adns8	1570	4	AIDS	AIDS	NNP
cord-023168-cd7adns8	1570	5	-	-	HYPH
cord-023168-cd7adns8	1570	6	related	relate	VBN
cord-023168-cd7adns8	1570	7	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1570	8	Leptomeningeal	Leptomeningeal	NNP
cord-023168-cd7adns8	1570	9	disease	disease	NN
cord-023168-cd7adns8	1570	10	in	in	IN
cord-023168-cd7adns8	1570	11	AIDS	AIDS	NNP
cord-023168-cd7adns8	1570	12	-	-	HYPH
cord-023168-cd7adns8	1570	13	related	relate	VBN
cord-023168-cd7adns8	1570	14	non	non	JJ
cord-023168-cd7adns8	1570	15	-	-	JJ
cord-023168-cd7adns8	1570	16	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1570	17	's	's	POS
cord-023168-cd7adns8	1570	18	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1570	19	AIDS	AIDS	NNP
cord-023168-cd7adns8	1570	20	-	-	HYPH
cord-023168-cd7adns8	1570	21	associated	associate	VBN
cord-023168-cd7adns8	1570	22	malignancies	malignancy	NNS
cord-023168-cd7adns8	1570	23	Human	human	JJ
cord-023168-cd7adns8	1570	24	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1570	25	virus	virus	NN
cord-023168-cd7adns8	1570	26	-	-	HYPH
cord-023168-cd7adns8	1570	27	related	relate	VBN
cord-023168-cd7adns8	1570	28	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1570	29	:	:	:
cord-023168-cd7adns8	1570	30	relation	relation	NN
cord-023168-cd7adns8	1570	31	between	between	IN
cord-023168-cd7adns8	1570	32	clinical	clinical	JJ
cord-023168-cd7adns8	1570	33	features	feature	NNS
cord-023168-cd7adns8	1570	34	and	and	CC
cord-023168-cd7adns8	1570	35	histologic	histologic	JJ
cord-023168-cd7adns8	1570	36	subtypes	subtype	NNS
cord-023168-cd7adns8	1571	1	A	a	DT
cord-023168-cd7adns8	1571	2	prognostic	prognostic	JJ
cord-023168-cd7adns8	1571	3	index	index	NN
cord-023168-cd7adns8	1571	4	for	for	IN
cord-023168-cd7adns8	1571	5	systemic	systemic	JJ
cord-023168-cd7adns8	1571	6	AIDS	AIDS	NNP
cord-023168-cd7adns8	1571	7	-	-	HYPH
cord-023168-cd7adns8	1571	8	related	relate	VBN
cord-023168-cd7adns8	1571	9	non	non	JJ
cord-023168-cd7adns8	1571	10	-	-	JJ
cord-023168-cd7adns8	1571	11	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1571	12	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1571	13	treated	treat	VBN
cord-023168-cd7adns8	1571	14	in	in	IN
cord-023168-cd7adns8	1571	15	the	the	DT
cord-023168-cd7adns8	1571	16	era	era	NN
cord-023168-cd7adns8	1571	17	of	of	IN
cord-023168-cd7adns8	1571	18	highly	highly	RB
cord-023168-cd7adns8	1571	19	active	active	JJ
cord-023168-cd7adns8	1571	20	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1571	21	therapy	therapy	NN
cord-023168-cd7adns8	1571	22	Clinical	clinical	JJ
cord-023168-cd7adns8	1571	23	features	feature	NNS
cord-023168-cd7adns8	1571	24	and	and	CC
cord-023168-cd7adns8	1571	25	outcome	outcome	NN
cord-023168-cd7adns8	1571	26	of	of	IN
cord-023168-cd7adns8	1571	27	primary	primary	JJ
cord-023168-cd7adns8	1571	28	effusion	effusion	NN
cord-023168-cd7adns8	1571	29	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1571	30	in	in	IN
cord-023168-cd7adns8	1571	31	HIV	HIV	NNP
cord-023168-cd7adns8	1571	32	-	-	HYPH
cord-023168-cd7adns8	1571	33	infected	infect	VBN
cord-023168-cd7adns8	1571	34	patients	patient	NNS
cord-023168-cd7adns8	1571	35	:	:	:
cord-023168-cd7adns8	1572	1	a	a	DT
cord-023168-cd7adns8	1572	2	singleinstitution	singleinstitution	NN
cord-023168-cd7adns8	1572	3	study	study	NN
cord-023168-cd7adns8	1572	4	Primary	primary	JJ
cord-023168-cd7adns8	1572	5	effusion	effusion	NN
cord-023168-cd7adns8	1572	6	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1572	7	Prognostic	prognostic	JJ
cord-023168-cd7adns8	1572	8	factors	factor	NNS
cord-023168-cd7adns8	1572	9	in	in	IN
cord-023168-cd7adns8	1572	10	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1572	11	-	-	HYPH
cord-023168-cd7adns8	1572	12	treated	treat	VBN
cord-023168-cd7adns8	1572	13	patients	patient	NNS
cord-023168-cd7adns8	1572	14	with	with	IN
cord-023168-cd7adns8	1572	15	HIV	HIV	NNP
cord-023168-cd7adns8	1572	16	-	-	HYPH
cord-023168-cd7adns8	1572	17	associated	associate	VBN
cord-023168-cd7adns8	1572	18	plasmablastic	plasmablastic	JJ
cord-023168-cd7adns8	1572	19	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1572	20	Molecular	Molecular	NNP
cord-023168-cd7adns8	1572	21	profile	profile	NN
cord-023168-cd7adns8	1572	22	of	of	IN
cord-023168-cd7adns8	1572	23	Epstein	Epstein	NNP
cord-023168-cd7adns8	1572	24	-	-	HYPH
cord-023168-cd7adns8	1572	25	Barr	Barr	NNP
cord-023168-cd7adns8	1572	26	virus	virus	NN
cord-023168-cd7adns8	1572	27	in	in	IN
cord-023168-cd7adns8	1572	28	human	human	JJ
cord-023168-cd7adns8	1572	29	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1572	30	virus	virus	NN
cord-023168-cd7adns8	1572	31	type	type	NN
cord-023168-cd7adns8	1572	32	1-related	1-related	CD
cord-023168-cd7adns8	1572	33	lymphadenopathies	lymphadenopathy	NNS
cord-023168-cd7adns8	1572	34	and	and	CC
cord-023168-cd7adns8	1572	35	lymphomas	lymphoma	NNS
cord-023168-cd7adns8	1572	36	Chemotherapy	Chemotherapy	NNP
cord-023168-cd7adns8	1572	37	for	for	IN
cord-023168-cd7adns8	1572	38	human	human	JJ
cord-023168-cd7adns8	1572	39	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1572	40	virus	virus	NN
cord-023168-cd7adns8	1572	41	-	-	HYPH
cord-023168-cd7adns8	1572	42	associated	associate	VBN
cord-023168-cd7adns8	1572	43	non	non	NNP
cord-023168-cd7adns8	1572	44	-	-	NNP
cord-023168-cd7adns8	1572	45	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1572	46	's	's	POS
cord-023168-cd7adns8	1572	47	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1572	48	in	in	IN
cord-023168-cd7adns8	1572	49	combination	combination	NN
cord-023168-cd7adns8	1572	50	with	with	IN
cord-023168-cd7adns8	1572	51	highly	highly	RB
cord-023168-cd7adns8	1572	52	active	active	JJ
cord-023168-cd7adns8	1572	53	antiretroviral	antiretroviral	JJ
cord-023168-cd7adns8	1572	54	therapy	therapy	NN
cord-023168-cd7adns8	1572	55	Rituximab	Rituximab	NNPS
cord-023168-cd7adns8	1572	56	plus	plus	CC
cord-023168-cd7adns8	1572	57	infusional	infusional	JJ
cord-023168-cd7adns8	1572	58	cyclophosphamide	cyclophosphamide	NN
cord-023168-cd7adns8	1572	59	,	,	,
cord-023168-cd7adns8	1572	60	doxorubicin	doxorubicin	NN
cord-023168-cd7adns8	1572	61	,	,	,
cord-023168-cd7adns8	1572	62	and	and	CC
cord-023168-cd7adns8	1572	63	etoposide	etoposide	VBD
cord-023168-cd7adns8	1572	64	in	in	IN
cord-023168-cd7adns8	1572	65	HIV	HIV	NNP
cord-023168-cd7adns8	1572	66	-	-	HYPH
cord-023168-cd7adns8	1572	67	associated	associate	VBN
cord-023168-cd7adns8	1572	68	non	non	NNP
cord-023168-cd7adns8	1572	69	-	-	JJ
cord-023168-cd7adns8	1572	70	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1572	71	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1572	72	:	:	:
cord-023168-cd7adns8	1572	73	pooled	pool	VBN
cord-023168-cd7adns8	1572	74	results	result	NNS
cord-023168-cd7adns8	1572	75	from	from	IN
cord-023168-cd7adns8	1572	76	3	3	CD
cord-023168-cd7adns8	1572	77	Phase	phase	NN
cord-023168-cd7adns8	1572	78	2	2	CD
cord-023168-cd7adns8	1572	79	trials	trial	NNS
cord-023168-cd7adns8	1572	80	Rituximab	Rituximab	NNPS
cord-023168-cd7adns8	1572	81	plus	plus	CC
cord-023168-cd7adns8	1573	1	concurrent	concurrent	JJ
cord-023168-cd7adns8	1573	2	infusional	infusional	JJ
cord-023168-cd7adns8	1573	3	EPOCH	epoch	NN
cord-023168-cd7adns8	1573	4	chemotherapy	chemotherapy	NN
cord-023168-cd7adns8	1573	5	is	be	VBZ
cord-023168-cd7adns8	1573	6	highly	highly	RB
cord-023168-cd7adns8	1573	7	effective	effective	JJ
cord-023168-cd7adns8	1573	8	in	in	IN
cord-023168-cd7adns8	1573	9	HIV	HIV	NNP
cord-023168-cd7adns8	1573	10	-	-	HYPH
cord-023168-cd7adns8	1573	11	associated	associate	VBN
cord-023168-cd7adns8	1573	12	B	b	NN
cord-023168-cd7adns8	1573	13	-	-	HYPH
cord-023168-cd7adns8	1573	14	cell	cell	NN
cord-023168-cd7adns8	1573	15	non	non	JJ
cord-023168-cd7adns8	1573	16	-	-	JJ
cord-023168-cd7adns8	1573	17	Hodgkin	Hodgkin	NNP
cord-023168-cd7adns8	1573	18	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1573	19	Factor	factor	NN
cord-023168-cd7adns8	1573	20	replacement	replacement	NN
cord-023168-cd7adns8	1573	21	therapy	therapy	NN
cord-023168-cd7adns8	1573	22	in	in	IN
cord-023168-cd7adns8	1573	23	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1573	24	-are	-are	.
cord-023168-cd7adns8	1574	1	there	there	EX
cord-023168-cd7adns8	1574	2	models	model	NNS
cord-023168-cd7adns8	1574	3	for	for	IN
cord-023168-cd7adns8	1574	4	developing	develop	VBG
cord-023168-cd7adns8	1574	5	countries	country	NNS
cord-023168-cd7adns8	1574	6	?	?	.
cord-023168-cd7adns8	1575	1	Hemophilia	Hemophilia	NNP
cord-023168-cd7adns8	1575	2	treatment	treatment	NN
cord-023168-cd7adns8	1575	3	in	in	IN
cord-023168-cd7adns8	1575	4	developing	develop	VBG
cord-023168-cd7adns8	1575	5	countries	country	NNS
cord-023168-cd7adns8	1575	6	:	:	:
cord-023168-cd7adns8	1575	7	products	product	NNS
cord-023168-cd7adns8	1575	8	and	and	CC
cord-023168-cd7adns8	1575	9	protocols	protocol	NNS
cord-023168-cd7adns8	1575	10	Management	Management	NNP
cord-023168-cd7adns8	1575	11	of	of	IN
cord-023168-cd7adns8	1575	12	haemophilia	haemophilia	NN
cord-023168-cd7adns8	1575	13	in	in	IN
cord-023168-cd7adns8	1575	14	the	the	DT
cord-023168-cd7adns8	1575	15	developing	develop	VBG
cord-023168-cd7adns8	1575	16	world	world	NN
cord-023168-cd7adns8	1575	17	Products	product	NNS
cord-023168-cd7adns8	1575	18	for	for	IN
cord-023168-cd7adns8	1575	19	clotting	clotting	NN
cord-023168-cd7adns8	1575	20	factor	factor	NN
cord-023168-cd7adns8	1575	21	replacement	replacement	NN
cord-023168-cd7adns8	1575	22	in	in	IN
cord-023168-cd7adns8	1575	23	developing	develop	VBG
cord-023168-cd7adns8	1575	24	countries	country	NNS
cord-023168-cd7adns8	1575	25	Management	Management	NNP
cord-023168-cd7adns8	1575	26	of	of	IN
cord-023168-cd7adns8	1575	27	hemophilia	hemophilia	NN
cord-023168-cd7adns8	1575	28	with	with	IN
cord-023168-cd7adns8	1575	29	minimal	minimal	JJ
cord-023168-cd7adns8	1575	30	factor	factor	NN
cord-023168-cd7adns8	1575	31	replacement	replacement	NN
cord-023168-cd7adns8	1575	32	in	in	IN
cord-023168-cd7adns8	1575	33	developing	develop	VBG
cord-023168-cd7adns8	1575	34	countries	country	NNS
cord-023168-cd7adns8	1575	35	:	:	:
cord-023168-cd7adns8	1575	36	role	role	NN
cord-023168-cd7adns8	1575	37	of	of	IN
cord-023168-cd7adns8	1575	38	ancillary	ancillary	JJ
cord-023168-cd7adns8	1575	39	therapy	therapy	NN
cord-023168-cd7adns8	1576	1	Danazol	danazol	NN
cord-023168-cd7adns8	1576	2	increases	increase	VBZ
cord-023168-cd7adns8	1576	3	factor	factor	NN
cord-023168-cd7adns8	1576	4	VIII	VIII	NNP
cord-023168-cd7adns8	1576	5	and	and	CC
cord-023168-cd7adns8	1576	6	IX	IX	NNP
cord-023168-cd7adns8	1576	7	in	in	IN
cord-023168-cd7adns8	1576	8	classical	classical	JJ
cord-023168-cd7adns8	1576	9	hemophilia	hemophilia	NN
cord-023168-cd7adns8	1576	10	and	and	CC
cord-023168-cd7adns8	1576	11	Christmas	Christmas	NNP
cord-023168-cd7adns8	1576	12	disease	disease	NN
cord-023168-cd7adns8	1576	13	HIV	HIV	NNP
cord-023168-cd7adns8	1576	14	and	and	CC
cord-023168-cd7adns8	1576	15	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1576	16	:	:	:
cord-023168-cd7adns8	1576	17	a	a	DT
cord-023168-cd7adns8	1576	18	review	review	NN
cord-023168-cd7adns8	1576	19	Venous	venous	JJ
cord-023168-cd7adns8	1576	20	thromboembolic	thromboembolic	JJ
cord-023168-cd7adns8	1576	21	disease	disease	NN
cord-023168-cd7adns8	1576	22	in	in	IN
cord-023168-cd7adns8	1576	23	the	the	DT
cord-023168-cd7adns8	1576	24	HIV	HIV	NNP
cord-023168-cd7adns8	1576	25	-	-	HYPH
cord-023168-cd7adns8	1576	26	infected	infect	VBN
cord-023168-cd7adns8	1576	27	patient	patient	NN
cord-023168-cd7adns8	1576	28	Systemic	systemic	JJ
cord-023168-cd7adns8	1576	29	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1576	30	in	in	IN
cord-023168-cd7adns8	1576	31	endomyocardial	endomyocardial	JJ
cord-023168-cd7adns8	1576	32	fibrosis	fibrosis	NN
cord-023168-cd7adns8	1576	33	(	(	-LRB-
cord-023168-cd7adns8	1576	34	EMF	EMF	NNP
cord-023168-cd7adns8	1576	35	)	)	-RRB-
cord-023168-cd7adns8	1576	36	:	:	:
cord-023168-cd7adns8	1576	37	clinical	clinical	JJ
cord-023168-cd7adns8	1576	38	observations	observation	NNS
cord-023168-cd7adns8	1576	39	,	,	,
cord-023168-cd7adns8	1576	40	aetio	aetio	NN
cord-023168-cd7adns8	1576	41	-	-	HYPH
cord-023168-cd7adns8	1576	42	pathogenesis	pathogenesis	NN
cord-023168-cd7adns8	1576	43	and	and	CC
cord-023168-cd7adns8	1576	44	treatment	treatment	NN
cord-023168-cd7adns8	1576	45	Effects	effect	NNS
cord-023168-cd7adns8	1576	46	of	of	IN
cord-023168-cd7adns8	1576	47	race	race	NN
cord-023168-cd7adns8	1576	48	and	and	CC
cord-023168-cd7adns8	1576	49	ethnicity	ethnicity	NN
cord-023168-cd7adns8	1576	50	on	on	IN
cord-023168-cd7adns8	1576	51	the	the	DT
cord-023168-cd7adns8	1576	52	incidence	incidence	NN
cord-023168-cd7adns8	1576	53	of	of	IN
cord-023168-cd7adns8	1576	54	venous	venous	JJ
cord-023168-cd7adns8	1576	55	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1576	56	Pulmonary	pulmonary	JJ
cord-023168-cd7adns8	1576	57	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1576	58	in	in	IN
cord-023168-cd7adns8	1576	59	an	an	DT
cord-023168-cd7adns8	1576	60	East	east	JJ
cord-023168-cd7adns8	1576	61	African	african	JJ
cord-023168-cd7adns8	1576	62	tertiary	tertiary	JJ
cord-023168-cd7adns8	1576	63	referral	referral	NN
cord-023168-cd7adns8	1576	64	hospital	hospital	NN
cord-023168-cd7adns8	1576	65	Epidemiology	epidemiology	NN
cord-023168-cd7adns8	1576	66	of	of	IN
cord-023168-cd7adns8	1576	67	postoperative	postoperative	JJ
cord-023168-cd7adns8	1576	68	venous	venous	JJ
cord-023168-cd7adns8	1576	69	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1576	70	in	in	IN
cord-023168-cd7adns8	1576	71	Asian	asian	JJ
cord-023168-cd7adns8	1576	72	countries	country	NNS
cord-023168-cd7adns8	1576	73	Risk	risk	NN
cord-023168-cd7adns8	1576	74	factors	factor	NNS
cord-023168-cd7adns8	1576	75	for	for	IN
cord-023168-cd7adns8	1576	76	symptomatic	symptomatic	JJ
cord-023168-cd7adns8	1576	77	venous	venous	JJ
cord-023168-cd7adns8	1576	78	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1576	79	in	in	IN
cord-023168-cd7adns8	1576	80	Thai	Thai	NNP
cord-023168-cd7adns8	1576	81	hospitalised	hospitalise	VBD
cord-023168-cd7adns8	1576	82	medical	medical	JJ
cord-023168-cd7adns8	1576	83	patients	patient	NNS
cord-023168-cd7adns8	1576	84	High	high	JJ
cord-023168-cd7adns8	1576	85	incidence	incidence	NN
cord-023168-cd7adns8	1576	86	of	of	IN
cord-023168-cd7adns8	1576	87	symptomatic	symptomatic	JJ
cord-023168-cd7adns8	1576	88	venous	venous	JJ
cord-023168-cd7adns8	1576	89	thromboembolism	thromboembolism	NN
cord-023168-cd7adns8	1576	90	in	in	IN
cord-023168-cd7adns8	1576	91	Thai	Thai	NNP
cord-023168-cd7adns8	1576	92	hospitalized	hospitalize	VBD
cord-023168-cd7adns8	1576	93	medical	medical	JJ
cord-023168-cd7adns8	1576	94	patients	patient	NNS
cord-023168-cd7adns8	1576	95	without	without	IN
cord-023168-cd7adns8	1576	96	thromboprophylaxis	thromboprophylaxis	NN
cord-023168-cd7adns8	1576	97	Prevalence	prevalence	NN
cord-023168-cd7adns8	1576	98	of	of	IN
cord-023168-cd7adns8	1576	99	factor	factor	NN
cord-023168-cd7adns8	1577	1	V	V	NNP
cord-023168-cd7adns8	1577	2	Leiden	Leiden	NNP
cord-023168-cd7adns8	1577	3	in	in	IN
cord-023168-cd7adns8	1577	4	south	south	JJ
cord-023168-cd7adns8	1577	5	Tunisian	tunisian	JJ
cord-023168-cd7adns8	1577	6	blood	blood	NN
cord-023168-cd7adns8	1577	7	donors	donor	NNS
cord-023168-cd7adns8	1578	1	Prevalence	prevalence	NN
cord-023168-cd7adns8	1578	2	of	of	IN
cord-023168-cd7adns8	1578	3	factor	factor	NN
cord-023168-cd7adns8	1578	4	V	V	NNP
cord-023168-cd7adns8	1578	5	Leiden	Leiden	NNP
cord-023168-cd7adns8	1578	6	mutation	mutation	NN
cord-023168-cd7adns8	1578	7	in	in	IN
cord-023168-cd7adns8	1578	8	patients	patient	NNS
cord-023168-cd7adns8	1578	9	with	with	IN
cord-023168-cd7adns8	1578	10	thrombosis	thrombosis	NN
cord-023168-cd7adns8	1578	11	in	in	IN
cord-023168-cd7adns8	1578	12	Tunisia	Tunisia	NNP
cord-023168-cd7adns8	1578	13	Lupus	Lupus	NNP
cord-023168-cd7adns8	1578	14	anticoagulant	anticoagulant	NN
cord-023168-cd7adns8	1578	15	in	in	IN
cord-023168-cd7adns8	1578	16	Nigerian	nigerian	JJ
cord-023168-cd7adns8	1578	17	patients	patient	NNS
cord-023168-cd7adns8	1578	18	living	live	VBG
cord-023168-cd7adns8	1578	19	with	with	IN
cord-023168-cd7adns8	1578	20	human	human	JJ
cord-023168-cd7adns8	1578	21	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1578	22	virus/	virus/	CD
cord-023168-cd7adns8	1578	23	acquired	acquire	VBN
cord-023168-cd7adns8	1578	24	immunodeficiency	immunodeficiency	NN
cord-023168-cd7adns8	1578	25	syndrome	syndrome	NN
cord-023168-cd7adns8	1578	26	Lupus	Lupus	NNP
cord-023168-cd7adns8	1578	27	anticoagulant	anticoagulant	NN
cord-023168-cd7adns8	1578	28	in	in	IN
cord-023168-cd7adns8	1578	29	Nigerian	nigerian	JJ
cord-023168-cd7adns8	1578	30	women	woman	NNS
cord-023168-cd7adns8	1578	31	with	with	IN
cord-023168-cd7adns8	1578	32	preeclampsia	preeclampsia	JJ
cord-023168-cd7adns8	1578	33	Translation	translation	NN
cord-023168-cd7adns8	1578	34	of	of	IN
cord-023168-cd7adns8	1578	35	cure	cure	NN
cord-023168-cd7adns8	1578	36	for	for	IN
cord-023168-cd7adns8	1578	37	acute	acute	JJ
cord-023168-cd7adns8	1578	38	lymphoblastic	lymphoblastic	JJ
cord-023168-cd7adns8	1578	39	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1578	40	to	to	IN
cord-023168-cd7adns8	1578	41	all	all	DT
cord-023168-cd7adns8	1578	42	children	child	NNS
cord-023168-cd7adns8	1578	43	An	an	DT
cord-023168-cd7adns8	1578	44	approach	approach	NN
cord-023168-cd7adns8	1578	45	to	to	IN
cord-023168-cd7adns8	1578	46	the	the	DT
cord-023168-cd7adns8	1578	47	management	management	NN
cord-023168-cd7adns8	1578	48	of	of	IN
cord-023168-cd7adns8	1578	49	leukemia	leukemia	NN
cord-023168-cd7adns8	1578	50	in	in	IN
cord-023168-cd7adns8	1578	51	the	the	DT
cord-023168-cd7adns8	1578	52	developing	develop	VBG
cord-023168-cd7adns8	1578	53	world	world	NN
cord-023168-cd7adns8	1578	54	Management	Management	NNP
cord-023168-cd7adns8	1578	55	of	of	IN
cord-023168-cd7adns8	1578	56	APL	APL	NNP
cord-023168-cd7adns8	1578	57	in	in	IN
cord-023168-cd7adns8	1578	58	developing	develop	VBG
cord-023168-cd7adns8	1578	59	countries	country	NNS
cord-023168-cd7adns8	1578	60	:	:	:
cord-023168-cd7adns8	1578	61	epidemiology	epidemiology	NN
cord-023168-cd7adns8	1578	62	,	,	,
cord-023168-cd7adns8	1578	63	challenges	challenge	NNS
cord-023168-cd7adns8	1578	64	and	and	CC
cord-023168-cd7adns8	1578	65	opportunities	opportunity	NNS
cord-023168-cd7adns8	1578	66	for	for	IN
cord-023168-cd7adns8	1578	67	international	international	JJ
cord-023168-cd7adns8	1578	68	collaboration	collaboration	NN
cord-023168-cd7adns8	1578	69	Arsenic	Arsenic	NNP
cord-023168-cd7adns8	1578	70	trioxide	trioxide	NN
cord-023168-cd7adns8	1578	71	in	in	IN
cord-023168-cd7adns8	1578	72	the	the	DT
cord-023168-cd7adns8	1578	73	treatment	treatment	NN
cord-023168-cd7adns8	1578	74	of	of	IN
cord-023168-cd7adns8	1578	75	newly	newly	RB
cord-023168-cd7adns8	1578	76	diagnosed	diagnose	VBN
cord-023168-cd7adns8	1578	77	acute	acute	JJ
cord-023168-cd7adns8	1578	78	promyelocytic	promyelocytic	NNP
cord-023168-cd7adns8	1578	79	leukemia	leukemia	NN
cord-023168-cd7adns8	1578	80	:	:	:
cord-023168-cd7adns8	1578	81	a	a	DT
cord-023168-cd7adns8	1578	82	single	single	JJ
cord-023168-cd7adns8	1578	83	center	center	NN
cord-023168-cd7adns8	1578	84	experience	experience	NN
cord-023168-cd7adns8	1578	85	Treatment	treatment	NN
cord-023168-cd7adns8	1578	86	of	of	IN
cord-023168-cd7adns8	1578	87	children	child	NNS
cord-023168-cd7adns8	1578	88	with	with	IN
cord-023168-cd7adns8	1578	89	newly	newly	RB
cord-023168-cd7adns8	1578	90	diagnosed	diagnose	VBN
cord-023168-cd7adns8	1578	91	acute	acute	JJ
cord-023168-cd7adns8	1578	92	promyelocytic	promyelocytic	JJ
cord-023168-cd7adns8	1578	93	leukemia	leukemia	NN
cord-023168-cd7adns8	1578	94	with	with	IN
cord-023168-cd7adns8	1578	95	arsenic	arsenic	NN
cord-023168-cd7adns8	1578	96	trioxide	trioxide	NN
cord-023168-cd7adns8	1578	97	:	:	:
cord-023168-cd7adns8	1578	98	a	a	DT
cord-023168-cd7adns8	1578	99	single	single	JJ
cord-023168-cd7adns8	1578	100	center	center	NN
cord-023168-cd7adns8	1578	101	experience	experience	NN
cord-023168-cd7adns8	1578	102	Treatment	treatment	NN
cord-023168-cd7adns8	1578	103	of	of	IN
cord-023168-cd7adns8	1578	104	childhood	childhood	NN
cord-023168-cd7adns8	1579	1	leukemias	leukemias	RB
cord-023168-cd7adns8	1579	2	in	in	IN
cord-023168-cd7adns8	1579	3	underprivileged	underprivileged	JJ
cord-023168-cd7adns8	1579	4	countries	country	NNS
cord-023168-cd7adns8	1580	1	Descriptive	descriptive	JJ
cord-023168-cd7adns8	1580	2	epidemiology	epidemiology	NN
cord-023168-cd7adns8	1580	3	of	of	IN
cord-023168-cd7adns8	1580	4	lymphoid	lymphoid	JJ
cord-023168-cd7adns8	1580	5	and	and	CC
cord-023168-cd7adns8	1580	6	haemopoietic	haemopoietic	JJ
cord-023168-cd7adns8	1580	7	malignancies	malignancy	NNS
cord-023168-cd7adns8	1580	8	in	in	IN
cord-023168-cd7adns8	1580	9	Bangalore	Bangalore	NNP
cord-023168-cd7adns8	1580	10	,	,	,
cord-023168-cd7adns8	1580	11	India	India	NNP
cord-023168-cd7adns8	1580	12	Outcome	outcome	NN
cord-023168-cd7adns8	1580	13	of	of	IN
cord-023168-cd7adns8	1580	14	childhood	childhood	NN
cord-023168-cd7adns8	1581	1	acute	acute	JJ
cord-023168-cd7adns8	1581	2	lymphoblastic	lymphoblastic	JJ
cord-023168-cd7adns8	1581	3	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1581	4	in	in	IN
cord-023168-cd7adns8	1581	5	resource	resource	NN
cord-023168-cd7adns8	1581	6	-	-	HYPH
cord-023168-cd7adns8	1581	7	poor	poor	JJ
cord-023168-cd7adns8	1581	8	countries	country	NNS
cord-023168-cd7adns8	1581	9	Establishment	Establishment	NNP
cord-023168-cd7adns8	1581	10	of	of	IN
cord-023168-cd7adns8	1581	11	a	a	DT
cord-023168-cd7adns8	1581	12	pediatric	pediatric	JJ
cord-023168-cd7adns8	1581	13	oncology	oncology	NN
cord-023168-cd7adns8	1581	14	program	program	NN
cord-023168-cd7adns8	1581	15	and	and	CC
cord-023168-cd7adns8	1581	16	outcomes	outcome	NNS
cord-023168-cd7adns8	1581	17	of	of	IN
cord-023168-cd7adns8	1581	18	childhood	childhood	NN
cord-023168-cd7adns8	1581	19	acute	acute	JJ
cord-023168-cd7adns8	1581	20	lymphoblastic	lymphoblastic	JJ
cord-023168-cd7adns8	1581	21	leukemia	leukemia	NN
cord-023168-cd7adns8	1581	22	in	in	IN
cord-023168-cd7adns8	1581	23	a	a	DT
cord-023168-cd7adns8	1581	24	resource	resource	NN
cord-023168-cd7adns8	1581	25	-	-	HYPH
cord-023168-cd7adns8	1581	26	poor	poor	JJ
cord-023168-cd7adns8	1581	27	area	area	NN
cord-023168-cd7adns8	1581	28	Lymphomas	Lymphomas	NNPS
cord-023168-cd7adns8	1581	29	in	in	IN
cord-023168-cd7adns8	1581	30	sub	sub	JJ
cord-023168-cd7adns8	1581	31	-	-	JJ
cord-023168-cd7adns8	1581	32	Saharan	saharan	JJ
cord-023168-cd7adns8	1581	33	Africa	Africa	NNP
cord-023168-cd7adns8	1582	1	-what	-what	.
cord-023168-cd7adns8	1583	1	can	can	MD
cord-023168-cd7adns8	1583	2	we	-PRON-	PRP
cord-023168-cd7adns8	1583	3	learn	learn	VB
cord-023168-cd7adns8	1583	4	and	and	CC
cord-023168-cd7adns8	1583	5	how	how	WRB
cord-023168-cd7adns8	1583	6	can	can	MD
cord-023168-cd7adns8	1583	7	we	-PRON-	PRP
cord-023168-cd7adns8	1583	8	help	help	VB
cord-023168-cd7adns8	1583	9	in	in	IN
cord-023168-cd7adns8	1583	10	improving	improve	VBG
cord-023168-cd7adns8	1583	11	diagnosis	diagnosis	NN
cord-023168-cd7adns8	1583	12	,	,	,
cord-023168-cd7adns8	1583	13	managing	manage	VBG
cord-023168-cd7adns8	1583	14	patients	patient	NNS
cord-023168-cd7adns8	1583	15	and	and	CC
cord-023168-cd7adns8	1583	16	fostering	foster	VBG
cord-023168-cd7adns8	1583	17	translational	translational	JJ
cord-023168-cd7adns8	1583	18	research	research	NN
cord-023168-cd7adns8	1583	19	?	?	.
cord-023168-cd7adns8	1584	1	Long	long	JJ
cord-023168-cd7adns8	1584	2	-	-	HYPH
cord-023168-cd7adns8	1584	3	term	term	NN
cord-023168-cd7adns8	1584	4	experience	experience	NN
cord-023168-cd7adns8	1584	5	with	with	IN
cord-023168-cd7adns8	1584	6	Burkitt	Burkitt	NNP
cord-023168-cd7adns8	1584	7	's	's	POS
cord-023168-cd7adns8	1584	8	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1584	9	in	in	IN
cord-023168-cd7adns8	1584	10	Uganda	Uganda	NNP
cord-023168-cd7adns8	1584	11	Adult	Adult	NNP
cord-023168-cd7adns8	1584	12	T	T	NNP
cord-023168-cd7adns8	1584	13	-	-	HYPH
cord-023168-cd7adns8	1584	14	cell	cell	NN
cord-023168-cd7adns8	1584	15	leukaemia	leukaemia	NN
cord-023168-cd7adns8	1584	16	/	/	SYM
cord-023168-cd7adns8	1584	17	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1584	18	Human	Human	NNP
cord-023168-cd7adns8	1584	19	T	T	NNP
cord-023168-cd7adns8	1584	20	-	-	HYPH
cord-023168-cd7adns8	1584	21	cell	cell	NN
cord-023168-cd7adns8	1584	22	leukemia	leukemia	NN
cord-023168-cd7adns8	1584	23	virus	virus	NN
cord-023168-cd7adns8	1584	24	type	type	NN
cord-023168-cd7adns8	1584	25	I	-PRON-	PRP
cord-023168-cd7adns8	1584	26	and	and	CC
cord-023168-cd7adns8	1584	27	adult	adult	NN
cord-023168-cd7adns8	1584	28	T	t	NN
cord-023168-cd7adns8	1584	29	-	-	HYPH
cord-023168-cd7adns8	1584	30	cell	cell	NN
cord-023168-cd7adns8	1584	31	leukemia	leukemia	NN
cord-023168-cd7adns8	1584	32	Identification	identification	NN
cord-023168-cd7adns8	1584	33	of	of	IN
cord-023168-cd7adns8	1584	34	subtype	subtype	NN
cord-023168-cd7adns8	1584	35	-	-	HYPH
cord-023168-cd7adns8	1584	36	specific	specific	JJ
cord-023168-cd7adns8	1584	37	genomic	genomic	JJ
cord-023168-cd7adns8	1584	38	alterations	alteration	NNS
cord-023168-cd7adns8	1584	39	in	in	IN
cord-023168-cd7adns8	1584	40	aggressive	aggressive	JJ
cord-023168-cd7adns8	1584	41	adult	adult	NN
cord-023168-cd7adns8	1584	42	T	t	NN
cord-023168-cd7adns8	1584	43	-	-	HYPH
cord-023168-cd7adns8	1584	44	cell	cell	NN
cord-023168-cd7adns8	1584	45	leukemia/	leukemia/	ADD
cord-023168-cd7adns8	1584	46	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1584	47	Treatment	treatment	NN
cord-023168-cd7adns8	1584	48	of	of	IN
cord-023168-cd7adns8	1584	49	adult	adult	NN
cord-023168-cd7adns8	1584	50	T	t	NN
cord-023168-cd7adns8	1584	51	-	-	HYPH
cord-023168-cd7adns8	1584	52	cell	cell	NN
cord-023168-cd7adns8	1584	53	leukemia	leukemia	NN
cord-023168-cd7adns8	1584	54	/	/	SYM
cord-023168-cd7adns8	1584	55	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1584	56	:	:	:
cord-023168-cd7adns8	1584	57	past	past	NN
cord-023168-cd7adns8	1584	58	,	,	,
cord-023168-cd7adns8	1584	59	present	present	JJ
cord-023168-cd7adns8	1584	60	,	,	,
cord-023168-cd7adns8	1584	61	and	and	CC
cord-023168-cd7adns8	1584	62	future	future	JJ
cord-023168-cd7adns8	1584	63	Current	current	JJ
cord-023168-cd7adns8	1584	64	management	management	NN
cord-023168-cd7adns8	1584	65	of	of	IN
cord-023168-cd7adns8	1584	66	adult	adult	NN
cord-023168-cd7adns8	1584	67	T	t	NN
cord-023168-cd7adns8	1584	68	-	-	HYPH
cord-023168-cd7adns8	1584	69	cell	cell	NN
cord-023168-cd7adns8	1584	70	leukemia	leukemia	NN
cord-023168-cd7adns8	1584	71	/	/	SYM
cord-023168-cd7adns8	1584	72	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1584	73	Meta	Meta	NNP
cord-023168-cd7adns8	1584	74	-	-	HYPH
cord-023168-cd7adns8	1584	75	analysis	analysis	NN
cord-023168-cd7adns8	1584	76	on	on	IN
cord-023168-cd7adns8	1584	77	the	the	DT
cord-023168-cd7adns8	1584	78	use	use	NN
cord-023168-cd7adns8	1584	79	of	of	IN
cord-023168-cd7adns8	1584	80	zidovudine	zidovudine	NN
cord-023168-cd7adns8	1584	81	and	and	CC
cord-023168-cd7adns8	1584	82	interferon	interferon	NN
cord-023168-cd7adns8	1584	83	-	-	HYPH
cord-023168-cd7adns8	1584	84	alfa	alfa	NNP
cord-023168-cd7adns8	1584	85	in	in	IN
cord-023168-cd7adns8	1584	86	adult	adult	NN
cord-023168-cd7adns8	1584	87	T	t	NN
cord-023168-cd7adns8	1584	88	-	-	HYPH
cord-023168-cd7adns8	1584	89	cell	cell	NN
cord-023168-cd7adns8	1584	90	leukemia/	leukemia/	ADD
cord-023168-cd7adns8	1584	91	lymphoma	lymphoma	NN
cord-023168-cd7adns8	1584	92	showing	show	VBG
cord-023168-cd7adns8	1584	93	improved	improve	VBN
cord-023168-cd7adns8	1584	94	survival	survival	NN
cord-023168-cd7adns8	1584	95	in	in	IN
cord-023168-cd7adns8	1584	96	the	the	DT
cord-023168-cd7adns8	1584	97	leukemic	leukemic	JJ
cord-023168-cd7adns8	1584	98	subtypes	subtype	NNS
cord-023168-cd7adns8	1584	99	Epidemiology	epidemiology	NN
cord-023168-cd7adns8	1584	100	of	of	IN
cord-023168-cd7adns8	1584	101	multiple	multiple	JJ
cord-023168-cd7adns8	1584	102	myeloma	myeloma	NN
cord-023168-cd7adns8	1584	103	in	in	IN
cord-023168-cd7adns8	1584	104	Taiwan	Taiwan	NNP
cord-023168-cd7adns8	1584	105	:	:	:
cord-023168-cd7adns8	1585	1	increasing	increase	VBG
cord-023168-cd7adns8	1585	2	incidence	incidence	NN
cord-023168-cd7adns8	1585	3	for	for	IN
cord-023168-cd7adns8	1585	4	the	the	DT
cord-023168-cd7adns8	1585	5	past	past	JJ
cord-023168-cd7adns8	1585	6	25	25	CD
cord-023168-cd7adns8	1585	7	years	year	NNS
cord-023168-cd7adns8	1585	8	and	and	CC
cord-023168-cd7adns8	1585	9	higher	high	JJR
cord-023168-cd7adns8	1585	10	prevalence	prevalence	NN
cord-023168-cd7adns8	1585	11	of	of	IN
cord-023168-cd7adns8	1585	12	extramedullary	extramedullary	JJ
cord-023168-cd7adns8	1585	13	myeloma	myeloma	NN
cord-023168-cd7adns8	1585	14	in	in	IN
cord-023168-cd7adns8	1585	15	patients	patient	NNS
cord-023168-cd7adns8	1585	16	younger	young	JJR
cord-023168-cd7adns8	1585	17	than	than	IN
cord-023168-cd7adns8	1585	18	55	55	CD
cord-023168-cd7adns8	1585	19	years	year	NNS
cord-023168-cd7adns8	1586	1	Reducing	reduce	VBG
cord-023168-cd7adns8	1586	2	replacement	replacement	NN
cord-023168-cd7adns8	1586	3	donors	donor	NNS
cord-023168-cd7adns8	1586	4	in	in	IN
cord-023168-cd7adns8	1586	5	sub	sub	JJ
cord-023168-cd7adns8	1586	6	-	-	JJ
cord-023168-cd7adns8	1586	7	Saharan	Saharan	NNP
cord-023168-cd7adns8	1586	8	Afirca	Afirca	NNP
cord-023168-cd7adns8	1586	9	:	:	:
cord-023168-cd7adns8	1586	10	challenges	challenge	NNS
cord-023168-cd7adns8	1586	11	and	and	CC
cord-023168-cd7adns8	1586	12	affordability	affordability	NN
cord-023168-cd7adns8	1586	13	Laboratory	laboratory	NN
cord-023168-cd7adns8	1586	14	costs	cost	NNS
cord-023168-cd7adns8	1586	15	of	of	IN
cord-023168-cd7adns8	1586	16	a	a	DT
cord-023168-cd7adns8	1586	17	hospital	hospital	NN
cord-023168-cd7adns8	1586	18	-	-	HYPH
cord-023168-cd7adns8	1586	19	based	base	VBN
cord-023168-cd7adns8	1586	20	blood	blood	NN
cord-023168-cd7adns8	1586	21	transfusion	transfusion	NN
cord-023168-cd7adns8	1586	22	service	service	NN
cord-023168-cd7adns8	1586	23	in	in	IN
cord-023168-cd7adns8	1586	24	Malawi	Malawi	NNP
cord-023168-cd7adns8	1586	25	From	from	IN
cord-023168-cd7adns8	1586	26	whole	whole	JJ
cord-023168-cd7adns8	1586	27	blood	blood	NN
cord-023168-cd7adns8	1586	28	to	to	IN
cord-023168-cd7adns8	1586	29	component	component	NN
cord-023168-cd7adns8	1586	30	therapy	therapy	NN
cord-023168-cd7adns8	1586	31	:	:	:
cord-023168-cd7adns8	1587	1	The	the	DT
cord-023168-cd7adns8	1587	2	economic	economic	JJ
cord-023168-cd7adns8	1587	3	,	,	,
cord-023168-cd7adns8	1587	4	supply/	supply/	JJ
cord-023168-cd7adns8	1587	5	demand	demand	NN
cord-023168-cd7adns8	1587	6	need	need	NN
cord-023168-cd7adns8	1587	7	for	for	IN
cord-023168-cd7adns8	1587	8	implementation	implementation	NN
cord-023168-cd7adns8	1587	9	of	of	IN
cord-023168-cd7adns8	1587	10	component	component	NN
cord-023168-cd7adns8	1587	11	therapy	therapy	NN
cord-023168-cd7adns8	1587	12	in	in	IN
cord-023168-cd7adns8	1587	13	sub	sub	JJ
cord-023168-cd7adns8	1587	14	-	-	JJ
cord-023168-cd7adns8	1587	15	Saharan	saharan	JJ
cord-023168-cd7adns8	1587	16	Africa	Africa	NNP
cord-023168-cd7adns8	1587	17	Warm	warm	JJ
cord-023168-cd7adns8	1587	18	fresh	fresh	JJ
cord-023168-cd7adns8	1587	19	whole	whole	JJ
cord-023168-cd7adns8	1587	20	blood	blood	NN
cord-023168-cd7adns8	1587	21	transfusion	transfusion	NN
cord-023168-cd7adns8	1587	22	for	for	IN
cord-023168-cd7adns8	1587	23	severe	severe	JJ
cord-023168-cd7adns8	1587	24	haemorrhage	haemorrhage	NN
cord-023168-cd7adns8	1587	25	:	:	:
cord-023168-cd7adns8	1588	1	US	US	NNP
cord-023168-cd7adns8	1588	2	military	military	NN
cord-023168-cd7adns8	1588	3	and	and	CC
cord-023168-cd7adns8	1588	4	potential	potential	JJ
cord-023168-cd7adns8	1588	5	civilian	civilian	JJ
cord-023168-cd7adns8	1588	6	applications	application	NNS
cord-023168-cd7adns8	1588	7	Moving	move	VBG
cord-023168-cd7adns8	1588	8	on	on	RP
cord-023168-cd7adns8	1588	9	from	from	IN
cord-023168-cd7adns8	1588	10	voluntary	voluntary	JJ
cord-023168-cd7adns8	1588	11	nonremunerated	nonremunerate	VBN
cord-023168-cd7adns8	1588	12	donors	donor	NNS
cord-023168-cd7adns8	1588	13	:	:	:
cord-023168-cd7adns8	1588	14	who	who	WP
cord-023168-cd7adns8	1588	15	is	be	VBZ
cord-023168-cd7adns8	1588	16	the	the	DT
cord-023168-cd7adns8	1588	17	best	good	JJS
cord-023168-cd7adns8	1588	18	blood	blood	NN
cord-023168-cd7adns8	1588	19	donor	donor	NN
cord-023168-cd7adns8	1588	20	Should	Should	MD
cord-023168-cd7adns8	1588	21	we	-PRON-	PRP
cord-023168-cd7adns8	1588	22	neglect	neglect	VB
cord-023168-cd7adns8	1588	23	or	or	CC
cord-023168-cd7adns8	1588	24	nurture	nurture	VB
cord-023168-cd7adns8	1588	25	replacement	replacement	NN
cord-023168-cd7adns8	1588	26	blood	blood	NN
cord-023168-cd7adns8	1588	27	donors	donor	NNS
cord-023168-cd7adns8	1588	28	in	in	IN
cord-023168-cd7adns8	1588	29	sub	sub	JJ
cord-023168-cd7adns8	1588	30	-	-	JJ
cord-023168-cd7adns8	1588	31	Saharan	Saharan	NNP
cord-023168-cd7adns8	1588	32	Africa	Africa	NNP
cord-023168-cd7adns8	1588	33	Joint	Joint	NNP
cord-023168-cd7adns8	1588	34	UKBTS	UKBTS	NNP
cord-023168-cd7adns8	1588	35	/	/	SYM
cord-023168-cd7adns8	1588	36	NIBSC	NIBSC	NNP
cord-023168-cd7adns8	1588	37	Professional	Professional	NNP
cord-023168-cd7adns8	1588	38	Advisory	Advisory	NNP
cord-023168-cd7adns8	1588	39	Committee	Committee	NNP
cord-023168-cd7adns8	1588	40	's	's	POS
cord-023168-cd7adns8	1588	41	(	(	-LRB-
cord-023168-cd7adns8	1588	42	JPAC	JPAC	NNP
cord-023168-cd7adns8	1588	43	)	)	-RRB-
cord-023168-cd7adns8	1588	44	Donor	Donor	NNP
cord-023168-cd7adns8	1588	45	Selection	Selection	NNP
cord-023168-cd7adns8	1588	46	Guidelines	Guidelines	NNPS
cord-023168-cd7adns8	1588	47	.	.	.
cord-023168-cd7adns8	1589	1	Guidelines	guideline	NNS
cord-023168-cd7adns8	1589	2	for	for	IN
cord-023168-cd7adns8	1589	3	the	the	DT
cord-023168-cd7adns8	1589	4	Blood	Blood	NNP
cord-023168-cd7adns8	1589	5	Transfusion	Transfusion	NNP
cord-023168-cd7adns8	1589	6	Services	Services	NNPS
cord-023168-cd7adns8	1589	7	in	in	IN
cord-023168-cd7adns8	1589	8	the	the	DT
cord-023168-cd7adns8	1589	9	UK	UK	NNP
cord-023168-cd7adns8	1590	1	Excluding	exclude	VBG
cord-023168-cd7adns8	1590	2	blood	blood	NN
cord-023168-cd7adns8	1590	3	donors	donor	NNS
cord-023168-cd7adns8	1590	4	at	at	IN
cord-023168-cd7adns8	1590	5	high	high	JJ
cord-023168-cd7adns8	1590	6	risk	risk	NN
cord-023168-cd7adns8	1590	7	of	of	IN
cord-023168-cd7adns8	1590	8	HIV	HIV	NNP
cord-023168-cd7adns8	1590	9	infection	infection	NN
cord-023168-cd7adns8	1590	10	in	in	IN
cord-023168-cd7adns8	1590	11	a	a	DT
cord-023168-cd7adns8	1590	12	West	west	JJ
cord-023168-cd7adns8	1590	13	African	african	JJ
cord-023168-cd7adns8	1590	14	city	city	NN
cord-023168-cd7adns8	1590	15	Possible	possible	JJ
cord-023168-cd7adns8	1590	16	transmission	transmission	NN
cord-023168-cd7adns8	1590	17	of	of	IN
cord-023168-cd7adns8	1590	18	variant	variant	JJ
cord-023168-cd7adns8	1590	19	Creutzfeldt	Creutzfeldt	NNP
cord-023168-cd7adns8	1590	20	-	-	HYPH
cord-023168-cd7adns8	1590	21	Jakob	Jakob	NNP
cord-023168-cd7adns8	1590	22	disease	disease	NN
cord-023168-cd7adns8	1590	23	by	by	IN
cord-023168-cd7adns8	1590	24	blood	blood	NN
cord-023168-cd7adns8	1590	25	transfusion	transfusion	NN
cord-023168-cd7adns8	1590	26	World	World	NNP
cord-023168-cd7adns8	1590	27	Health	Health	NNP
cord-023168-cd7adns8	1590	28	Organization	Organization	NNP
cord-023168-cd7adns8	1590	29	.	.	.
cord-023168-cd7adns8	1591	1	WHO	who	WP
cord-023168-cd7adns8	1591	2	recommendations	recommendation	VBZ
cord-023168-cd7adns8	1591	3	on	on	IN
cord-023168-cd7adns8	1591	4	SARS	SARS	NNP
cord-023168-cd7adns8	1591	5	and	and	CC
cord-023168-cd7adns8	1591	6	blood	blood	NN
cord-023168-cd7adns8	1591	7	safety	safety	NN
cord-023168-cd7adns8	1592	1	Transfusiontransmitted	transfusiontransmitte	VBN
cord-023168-cd7adns8	1592	2	malaria	malaria	NN
cord-023168-cd7adns8	1592	3	in	in	IN
cord-023168-cd7adns8	1592	4	countries	country	NNS
cord-023168-cd7adns8	1592	5	where	where	WRB
cord-023168-cd7adns8	1592	6	malaria	malaria	NN
cord-023168-cd7adns8	1592	7	is	be	VBZ
cord-023168-cd7adns8	1592	8	endemic	endemic	JJ
cord-023168-cd7adns8	1592	9	:	:	:
cord-023168-cd7adns8	1592	10	a	a	DT
cord-023168-cd7adns8	1592	11	review	review	NN
cord-023168-cd7adns8	1592	12	of	of	IN
cord-023168-cd7adns8	1592	13	the	the	DT
cord-023168-cd7adns8	1592	14	literature	literature	NN
cord-023168-cd7adns8	1592	15	from	from	IN
cord-023168-cd7adns8	1592	16	sub	sub	JJ
cord-023168-cd7adns8	1592	17	-	-	JJ
cord-023168-cd7adns8	1592	18	Saharan	saharan	JJ
cord-023168-cd7adns8	1592	19	Africa	Africa	NNP
cord-023168-cd7adns8	1593	1	The	the	DT
cord-023168-cd7adns8	1593	2	prevalence	prevalence	NN
cord-023168-cd7adns8	1593	3	of	of	IN
cord-023168-cd7adns8	1593	4	malaria	malaria	NN
cord-023168-cd7adns8	1593	5	parasitaemia	parasitaemia	NN
cord-023168-cd7adns8	1593	6	in	in	IN
cord-023168-cd7adns8	1593	7	blood	blood	NN
cord-023168-cd7adns8	1593	8	donors	donor	NNS
cord-023168-cd7adns8	1593	9	in	in	IN
cord-023168-cd7adns8	1593	10	a	a	DT
cord-023168-cd7adns8	1593	11	Nigerian	nigerian	JJ
cord-023168-cd7adns8	1593	12	teaching	teaching	NN
cord-023168-cd7adns8	1593	13	hospital	hospital	NN
cord-023168-cd7adns8	1593	14	Transfusion	Transfusion	NNP
cord-023168-cd7adns8	1593	15	-	-	HYPH
cord-023168-cd7adns8	1593	16	transmitted	transmit	VBN
cord-023168-cd7adns8	1593	17	syphilis	syphili	NNS
cord-023168-cd7adns8	1593	18	in	in	IN
cord-023168-cd7adns8	1593	19	teaching	teach	VBG
cord-023168-cd7adns8	1593	20	hospital	hospital	NN
cord-023168-cd7adns8	1593	21	Predonation	Predonation	NNP
cord-023168-cd7adns8	1593	22	screening	screening	NN
cord-023168-cd7adns8	1593	23	of	of	IN
cord-023168-cd7adns8	1593	24	blood	blood	NN
cord-023168-cd7adns8	1593	25	donors	donor	NNS
cord-023168-cd7adns8	1593	26	with	with	IN
cord-023168-cd7adns8	1593	27	rapid	rapid	JJ
cord-023168-cd7adns8	1593	28	tests	test	NNS
cord-023168-cd7adns8	1593	29	:	:	:
cord-023168-cd7adns8	1594	1	implementation	implementation	NN
cord-023168-cd7adns8	1594	2	and	and	CC
cord-023168-cd7adns8	1594	3	efficacy	efficacy	NN
cord-023168-cd7adns8	1594	4	of	of	IN
cord-023168-cd7adns8	1594	5	a	a	DT
cord-023168-cd7adns8	1594	6	novel	novel	JJ
cord-023168-cd7adns8	1594	7	approach	approach	NN
cord-023168-cd7adns8	1594	8	to	to	IN
cord-023168-cd7adns8	1594	9	blood	blood	NN
cord-023168-cd7adns8	1594	10	safety	safety	NN
cord-023168-cd7adns8	1594	11	in	in	IN
cord-023168-cd7adns8	1594	12	resource	resource	NN
cord-023168-cd7adns8	1594	13	-	-	HYPH
cord-023168-cd7adns8	1594	14	poor	poor	JJ
cord-023168-cd7adns8	1594	15	settings	setting	NNS
cord-023168-cd7adns8	1594	16	Blood	blood	NN
cord-023168-cd7adns8	1594	17	donors	donor	NNS
cord-023168-cd7adns8	1594	18	and	and	CC
cord-023168-cd7adns8	1594	19	blood	blood	NN
cord-023168-cd7adns8	1594	20	collecton	collecton	NN
cord-023168-cd7adns8	1594	21	:	:	:
cord-023168-cd7adns8	1595	1	Web	web	NN
cord-023168-cd7adns8	1595	2	interface	interface	NN
cord-023168-cd7adns8	1595	3	-	-	HYPH
cord-023168-cd7adns8	1595	4	supported	support	VBN
cord-023168-cd7adns8	1595	5	transmission	transmission	NN
cord-023168-cd7adns8	1595	6	risk	risk	NN
cord-023168-cd7adns8	1595	7	assessment	assessment	NN
cord-023168-cd7adns8	1595	8	and	and	CC
cord-023168-cd7adns8	1595	9	cost	cost	NN
cord-023168-cd7adns8	1595	10	-	-	HYPH
cord-023168-cd7adns8	1595	11	effectiveness	effectiveness	NN
cord-023168-cd7adns8	1595	12	analysis	analysis	NN
cord-023168-cd7adns8	1595	13	of	of	IN
cord-023168-cd7adns8	1595	14	postdonation	postdonation	NN
cord-023168-cd7adns8	1595	15	screening	screening	NN
cord-023168-cd7adns8	1595	16	:	:	:
cord-023168-cd7adns8	1595	17	a	a	DT
cord-023168-cd7adns8	1595	18	global	global	JJ
cord-023168-cd7adns8	1595	19	model	model	NN
cord-023168-cd7adns8	1595	20	applied	apply	VBN
cord-023168-cd7adns8	1595	21	to	to	IN
cord-023168-cd7adns8	1595	22	Ghana	Ghana	NNP
cord-023168-cd7adns8	1595	23	Effect	Effect	NNP
cord-023168-cd7adns8	1595	24	of	of	IN
cord-023168-cd7adns8	1595	25	blood	blood	NN
cord-023168-cd7adns8	1595	26	transfusion	transfusion	NN
cord-023168-cd7adns8	1595	27	on	on	IN
cord-023168-cd7adns8	1595	28	survival	survival	NN
cord-023168-cd7adns8	1595	29	among	among	IN
cord-023168-cd7adns8	1595	30	children	child	NNS
cord-023168-cd7adns8	1595	31	in	in	IN
cord-023168-cd7adns8	1595	32	a	a	DT
cord-023168-cd7adns8	1595	33	Kenyan	kenyan	JJ
cord-023168-cd7adns8	1595	34	hospital	hospital	NN
cord-023168-cd7adns8	1595	35	Changing	change	VBG
cord-023168-cd7adns8	1595	36	trends	trend	NNS
cord-023168-cd7adns8	1595	37	in	in	IN
cord-023168-cd7adns8	1595	38	blood	blood	NN
cord-023168-cd7adns8	1595	39	transfusion	transfusion	NN
cord-023168-cd7adns8	1595	40	in	in	IN
cord-023168-cd7adns8	1595	41	children	child	NNS
cord-023168-cd7adns8	1595	42	and	and	CC
cord-023168-cd7adns8	1595	43	neonates	neonate	NNS
cord-023168-cd7adns8	1595	44	admitted	admit	VBN
cord-023168-cd7adns8	1595	45	in	in	IN
cord-023168-cd7adns8	1595	46	Kilifi	Kilifi	NNP
cord-023168-cd7adns8	1595	47	District	District	NNP
cord-023168-cd7adns8	1595	48	Hospital	Hospital	NNP
cord-023168-cd7adns8	1595	49	Maternal	maternal	JJ
cord-023168-cd7adns8	1595	50	mortality	mortality	NN
cord-023168-cd7adns8	1595	51	in	in	IN
cord-023168-cd7adns8	1595	52	sub	sub	JJ
cord-023168-cd7adns8	1595	53	-	-	JJ
cord-023168-cd7adns8	1595	54	Saharan	saharan	JJ
cord-023168-cd7adns8	1595	55	Africa	Africa	NNP
cord-023168-cd7adns8	1595	56	:	:	:
cord-023168-cd7adns8	1595	57	the	the	DT
cord-023168-cd7adns8	1595	58	contribution	contribution	NN
cord-023168-cd7adns8	1595	59	of	of	IN
cord-023168-cd7adns8	1595	60	ineffective	ineffective	JJ
cord-023168-cd7adns8	1595	61	blood	blood	NN
cord-023168-cd7adns8	1595	62	transfusion	transfusion	NN
cord-023168-cd7adns8	1595	63	services	service	NNS
cord-023168-cd7adns8	1595	64	Press	Press	NNP
cord-023168-cd7adns8	1595	65	release	release	NN
cord-023168-cd7adns8	1595	66	WHO/25	who/25	JJ
cord-023168-cd7adns8	1595	67	.	.	.
cord-023168-cd7adns8	1595	68	2000	2000	CD
cord-023168-cd7adns8	1595	69	.	.	.
cord-023168-cd7adns8	1596	1	WHD/3	WHD/3	NNP
cord-023168-cd7adns8	1597	1	Information	information	NN
cord-023168-cd7adns8	1597	2	sheet	sheet	NN
cord-023168-cd7adns8	1597	3	for	for	IN
cord-023168-cd7adns8	1597	4	clinicians	clinician	NNS
cord-023168-cd7adns8	1597	5	Development	Development	NNP
cord-023168-cd7adns8	1597	6	and	and	CC
cord-023168-cd7adns8	1597	7	evaluation	evaluation	NN
cord-023168-cd7adns8	1597	8	of	of	IN
cord-023168-cd7adns8	1597	9	a	a	DT
cord-023168-cd7adns8	1597	10	new	new	JJ
cord-023168-cd7adns8	1597	11	paediatric	paediatric	JJ
cord-023168-cd7adns8	1597	12	blood	blood	NN
cord-023168-cd7adns8	1597	13	transfusion	transfusion	NN
cord-023168-cd7adns8	1597	14	protocol	protocol	NN
cord-023168-cd7adns8	1597	15	for	for	IN
cord-023168-cd7adns8	1597	16	Africa	Africa	NNP
cord-023168-cd7adns8	1597	17	Electrocardiographic	Electrocardiographic	NNP
cord-023168-cd7adns8	1597	18	ST	ST	NNP
cord-023168-cd7adns8	1597	19	-	-	HYPH
cord-023168-cd7adns8	1597	20	segment	segment	NN
cord-023168-cd7adns8	1597	21	changes	change	NNS
cord-023168-cd7adns8	1597	22	during	during	IN
cord-023168-cd7adns8	1597	23	acute	acute	JJ
cord-023168-cd7adns8	1597	24	,	,	,
cord-023168-cd7adns8	1597	25	severe	severe	JJ
cord-023168-cd7adns8	1597	26	isovolemic	isovolemic	JJ
cord-023168-cd7adns8	1597	27	hemodilution	hemodilution	NN
cord-023168-cd7adns8	1597	28	in	in	IN
cord-023168-cd7adns8	1597	29	humans	human	NNS
cord-023168-cd7adns8	1597	30	Use	Use	NNP
cord-023168-cd7adns8	1597	31	of	of	IN
cord-023168-cd7adns8	1597	32	clinical	clinical	JJ
cord-023168-cd7adns8	1597	33	judgement	judgement	NN
cord-023168-cd7adns8	1597	34	to	to	TO
cord-023168-cd7adns8	1597	35	guide	guide	VB
cord-023168-cd7adns8	1597	36	administration	administration	NN
cord-023168-cd7adns8	1597	37	of	of	IN
cord-023168-cd7adns8	1597	38	blood	blood	NN
cord-023168-cd7adns8	1597	39	transfusions	transfusion	NNS
cord-023168-cd7adns8	1597	40	in	in	IN
cord-023168-cd7adns8	1597	41	Malawi	Malawi	NNP
cord-023168-cd7adns8	1597	42	Giving	give	VBG
cord-023168-cd7adns8	1597	43	tranexamic	tranexamic	JJ
cord-023168-cd7adns8	1597	44	acid	acid	NN
cord-023168-cd7adns8	1597	45	to	to	TO
cord-023168-cd7adns8	1597	46	reduce	reduce	VB
cord-023168-cd7adns8	1597	47	surgical	surgical	JJ
cord-023168-cd7adns8	1597	48	bleeding	bleeding	NN
cord-023168-cd7adns8	1597	49	in	in	IN
cord-023168-cd7adns8	1597	50	sub	sub	JJ
cord-023168-cd7adns8	1597	51	-	-	JJ
cord-023168-cd7adns8	1597	52	Saharan	saharan	JJ
cord-023168-cd7adns8	1597	53	Africa	Africa	NNP
cord-023168-cd7adns8	1597	54	:	:	:
cord-023168-cd7adns8	1597	55	an	an	DT
cord-023168-cd7adns8	1597	56	economic	economic	JJ
cord-023168-cd7adns8	1597	57	evaluation	evaluation	NN
cord-023168-cd7adns8	1597	58	Autologous	autologous	JJ
cord-023168-cd7adns8	1597	59	transfusion	transfusion	NN
cord-023168-cd7adns8	1597	60	techniques	technique	NNS
cord-023168-cd7adns8	1597	61	:	:	:
cord-023168-cd7adns8	1597	62	a	a	DT
cord-023168-cd7adns8	1597	63	systematic	systematic	JJ
cord-023168-cd7adns8	1597	64	review	review	NN
cord-023168-cd7adns8	1597	65	of	of	IN
cord-023168-cd7adns8	1597	66	their	-PRON-	PRP$
cord-023168-cd7adns8	1597	67	efficacy	efficacy	NN
cord-023168-cd7adns8	1597	68	Intraoperative	Intraoperative	NNP
cord-023168-cd7adns8	1597	69	autologous	autologous	JJ
cord-023168-cd7adns8	1597	70	blood	blood	NN
cord-023168-cd7adns8	1597	71	management	management	NN
cord-023168-cd7adns8	1597	72	Artificial	Artificial	NNP
cord-023168-cd7adns8	1597	73	O2	O2	NNP
cord-023168-cd7adns8	1597	74	carriers	carrier	NNS
cord-023168-cd7adns8	1597	75	:	:	:
cord-023168-cd7adns8	1597	76	status	status	NN
cord-023168-cd7adns8	1597	77	in	in	IN
cord-023168-cd7adns8	1597	78	2005	2005	CD
cord-023168-cd7adns8	1597	79	Red	red	JJ
cord-023168-cd7adns8	1597	80	blood	blood	NN
cord-023168-cd7adns8	1597	81	cell	cell	NN
cord-023168-cd7adns8	1597	82	transfusions	transfusion	NNS
cord-023168-cd7adns8	1597	83	in	in	IN
cord-023168-cd7adns8	1597	84	acute	acute	JJ
cord-023168-cd7adns8	1597	85	paediatrics	paediatric	NNS
cord-023168-cd7adns8	1597	86	Survival	survival	NN
cord-023168-cd7adns8	1597	87	and	and	CC
cord-023168-cd7adns8	1597	88	haematological	haematological	JJ
cord-023168-cd7adns8	1597	89	recovery	recovery	NN
cord-023168-cd7adns8	1597	90	of	of	IN
cord-023168-cd7adns8	1597	91	children	child	NNS
cord-023168-cd7adns8	1597	92	with	with	IN
cord-023168-cd7adns8	1597	93	severe	severe	JJ
cord-023168-cd7adns8	1597	94	malaria	malaria	NN
cord-023168-cd7adns8	1597	95	transfused	transfuse	VBN
cord-023168-cd7adns8	1597	96	in	in	IN
cord-023168-cd7adns8	1597	97	accordance	accordance	NN
cord-023168-cd7adns8	1597	98	to	to	IN
cord-023168-cd7adns8	1597	99	WHO	who	WP
cord-023168-cd7adns8	1597	100	guidelines	guideline	NNS
cord-023168-cd7adns8	1597	101	in	in	IN
cord-023168-cd7adns8	1597	102	Kilifi	Kilifi	NNP
cord-023168-cd7adns8	1597	103	Intermittent	intermittent	JJ
cord-023168-cd7adns8	1597	104	preventive	preventive	JJ
cord-023168-cd7adns8	1597	105	therapy	therapy	NN
cord-023168-cd7adns8	1597	106	for	for	IN
cord-023168-cd7adns8	1597	107	malaria	malaria	NN
cord-023168-cd7adns8	1597	108	with	with	IN
cord-023168-cd7adns8	1597	109	monthly	monthly	JJ
cord-023168-cd7adns8	1597	110	artemether	artemether	JJ
cord-023168-cd7adns8	1597	111	-	-	HYPH
cord-023168-cd7adns8	1597	112	lumefantrine	lumefantrine	NNP
cord-023168-cd7adns8	1597	113	for	for	IN
cord-023168-cd7adns8	1597	114	the	the	DT
cord-023168-cd7adns8	1597	115	post	post	JJ
cord-023168-cd7adns8	1597	116	-	-	JJ
cord-023168-cd7adns8	1597	117	discharge	discharge	JJ
cord-023168-cd7adns8	1597	118	management	management	NN
cord-023168-cd7adns8	1597	119	of	of	IN
cord-023168-cd7adns8	1597	120	severe	severe	JJ
cord-023168-cd7adns8	1597	121	anaemia	anaemia	NN
cord-023168-cd7adns8	1597	122	in	in	IN
cord-023168-cd7adns8	1597	123	children	child	NNS
cord-023168-cd7adns8	1597	124	aged	age	VBN
cord-023168-cd7adns8	1597	125	4	4	CD
cord-023168-cd7adns8	1597	126	-	-	SYM
cord-023168-cd7adns8	1597	127	59	59	CD
cord-023168-cd7adns8	1597	128	months	month	NNS
cord-023168-cd7adns8	1597	129	in	in	IN
cord-023168-cd7adns8	1597	130	southern	southern	JJ
cord-023168-cd7adns8	1597	131	Malawi	Malawi	NNP
cord-023168-cd7adns8	1597	132	:	:	:
cord-023168-cd7adns8	1597	133	a	a	DT
cord-023168-cd7adns8	1597	134	multicentre	multicentre	NNP
cord-023168-cd7adns8	1597	135	,	,	,
cord-023168-cd7adns8	1597	136	randomised	randomised	JJ
cord-023168-cd7adns8	1597	137	,	,	,
cord-023168-cd7adns8	1597	138	placebocontrolled	placebocontrolled	JJ
cord-023168-cd7adns8	1597	139	trial	trial	NN
cord-023168-cd7adns8	1597	140	Bacterial	bacterial	JJ
cord-023168-cd7adns8	1597	141	contamination	contamination	NN
cord-023168-cd7adns8	1597	142	of	of	IN
cord-023168-cd7adns8	1597	143	pediatric	pediatric	JJ
cord-023168-cd7adns8	1597	144	whole	whole	JJ
cord-023168-cd7adns8	1597	145	blood	blood	NN
cord-023168-cd7adns8	1597	146	transfusions	transfusion	NNS
cord-023168-cd7adns8	1597	147	in	in	IN
cord-023168-cd7adns8	1597	148	a	a	DT
cord-023168-cd7adns8	1597	149	Kenyan	kenyan	JJ
cord-023168-cd7adns8	1597	150	hospital	hospital	NN
cord-023168-cd7adns8	1597	151	Bacterial	bacterial	JJ
cord-023168-cd7adns8	1597	152	contamination	contamination	NN
cord-023168-cd7adns8	1597	153	of	of	IN
cord-023168-cd7adns8	1597	154	blood	blood	NN
cord-023168-cd7adns8	1597	155	and	and	CC
cord-023168-cd7adns8	1597	156	blood	blood	NN
cord-023168-cd7adns8	1597	157	components	component	NNS
cord-023168-cd7adns8	1597	158	in	in	IN
cord-023168-cd7adns8	1597	159	three	three	CD
cord-023168-cd7adns8	1597	160	major	major	JJ
cord-023168-cd7adns8	1597	161	blood	blood	NN
cord-023168-cd7adns8	1597	162	transfusion	transfusion	NN
cord-023168-cd7adns8	1597	163	centres	centre	NNS
cord-023168-cd7adns8	1597	164	in	in	IN
cord-023168-cd7adns8	1597	165	Accra	Accra	NNP
cord-023168-cd7adns8	1597	166	,	,	,
cord-023168-cd7adns8	1598	1	Ghana	Ghana	NNP
cord-023168-cd7adns8	1598	2	Access	Access	NNP
cord-023168-cd7adns8	1598	3	the	the	DT
cord-023168-cd7adns8	1598	4	complete	complete	JJ
cord-023168-cd7adns8	1598	5	references	reference	NNS
cord-023168-cd7adns8	1598	6	online	online	RB
cord-023168-cd7adns8	1598	7	at	at	IN
cord-023168-cd7adns8	1598	8	www.expertconsult.com	www.expertconsult.com	ADD