id sid tid token lemma pos cord-337137-0ey40gzw 1 1 key key NN cord-337137-0ey40gzw 1 2 : : : cord-337137-0ey40gzw 2 1 cord-337137 cord-337137 NNP cord-337137-0ey40gzw 2 2 - - HYPH cord-337137-0ey40gzw 2 3 0ey40gzw 0ey40gzw CD cord-337137-0ey40gzw 2 4 authors author NNS cord-337137-0ey40gzw 2 5 : : : cord-337137-0ey40gzw 2 6 Lo Lo NNP cord-337137-0ey40gzw 2 7 , , , cord-337137-0ey40gzw 2 8 Anthony Anthony NNP cord-337137-0ey40gzw 2 9 WI WI NNP cord-337137-0ey40gzw 2 10 ; ; : cord-337137-0ey40gzw 2 11 Tang Tang NNP cord-337137-0ey40gzw 2 12 , , , cord-337137-0ey40gzw 2 13 Nelson Nelson NNP cord-337137-0ey40gzw 2 14 LS LS NNP cord-337137-0ey40gzw 2 15 ; ; : cord-337137-0ey40gzw 3 1 To to TO cord-337137-0ey40gzw 3 2 , , , cord-337137-0ey40gzw 3 3 Ka‐Fai ka‐fai XX cord-337137-0ey40gzw 4 1 title title NN cord-337137-0ey40gzw 4 2 : : : cord-337137-0ey40gzw 5 1 How how WRB cord-337137-0ey40gzw 5 2 the the DT cord-337137-0ey40gzw 5 3 SARS SARS NNP cord-337137-0ey40gzw 5 4 coronavirus coronavirus NN cord-337137-0ey40gzw 5 5 causes cause VBZ cord-337137-0ey40gzw 5 6 disease disease NN cord-337137-0ey40gzw 5 7 : : : cord-337137-0ey40gzw 5 8 host host NN cord-337137-0ey40gzw 5 9 or or CC cord-337137-0ey40gzw 5 10 organism organism NN cord-337137-0ey40gzw 5 11 ? ? . cord-337137-0ey40gzw 6 1 date date NN cord-337137-0ey40gzw 6 2 : : : cord-337137-0ey40gzw 6 3 2005 2005 CD cord-337137-0ey40gzw 6 4 - - SYM cord-337137-0ey40gzw 6 5 12 12 CD cord-337137-0ey40gzw 6 6 - - SYM cord-337137-0ey40gzw 6 7 17 17 CD cord-337137-0ey40gzw 6 8 journal journal NN cord-337137-0ey40gzw 6 9 : : : cord-337137-0ey40gzw 7 1 J J NNP cord-337137-0ey40gzw 7 2 Pathol Pathol NNP cord-337137-0ey40gzw 7 3 DOI DOI NNP cord-337137-0ey40gzw 7 4 : : : cord-337137-0ey40gzw 7 5 10.1002 10.1002 CD cord-337137-0ey40gzw 7 6 / / SYM cord-337137-0ey40gzw 7 7 path.1897 path.1897 NN cord-337137-0ey40gzw 7 8 sha sha NNP cord-337137-0ey40gzw 7 9 : : : cord-337137-0ey40gzw 8 1 de304fcebb2bdcf4d30c71dc461e7eac9cb066b4 de304fcebb2bdcf4d30c71dc461e7eac9cb066b4 NNP cord-337137-0ey40gzw 8 2 doc_id doc_id CD cord-337137-0ey40gzw 8 3 : : : cord-337137-0ey40gzw 9 1 337137 337137 CD cord-337137-0ey40gzw 9 2 cord_uid cord_uid NNS cord-337137-0ey40gzw 9 3 : : : cord-337137-0ey40gzw 9 4 0ey40gzw 0ey40gzw CD cord-337137-0ey40gzw 10 1 The the DT cord-337137-0ey40gzw 10 2 previous previous JJ cord-337137-0ey40gzw 10 3 epidemic epidemic NN cord-337137-0ey40gzw 10 4 of of IN cord-337137-0ey40gzw 10 5 severe severe JJ cord-337137-0ey40gzw 10 6 acute acute JJ cord-337137-0ey40gzw 10 7 respiratory respiratory JJ cord-337137-0ey40gzw 10 8 syndrome syndrome NN cord-337137-0ey40gzw 10 9 ( ( -LRB- cord-337137-0ey40gzw 10 10 SARS SARS NNP cord-337137-0ey40gzw 10 11 ) ) -RRB- cord-337137-0ey40gzw 10 12 has have VBZ cord-337137-0ey40gzw 10 13 ended end VBN cord-337137-0ey40gzw 10 14 . . . cord-337137-0ey40gzw 11 1 However however RB cord-337137-0ey40gzw 11 2 , , , cord-337137-0ey40gzw 11 3 many many JJ cord-337137-0ey40gzw 11 4 questions question NNS cord-337137-0ey40gzw 11 5 concerning concern VBG cord-337137-0ey40gzw 11 6 how how WRB cord-337137-0ey40gzw 11 7 the the DT cord-337137-0ey40gzw 11 8 aetiological aetiological JJ cord-337137-0ey40gzw 11 9 agent agent NN cord-337137-0ey40gzw 11 10 , , , cord-337137-0ey40gzw 11 11 the the DT cord-337137-0ey40gzw 11 12 novel novel JJ cord-337137-0ey40gzw 11 13 SARS SARS NNP cord-337137-0ey40gzw 11 14 coronavirus coronavirus NN cord-337137-0ey40gzw 11 15 ( ( -LRB- cord-337137-0ey40gzw 11 16 CoV CoV NNP cord-337137-0ey40gzw 11 17 ) ) -RRB- cord-337137-0ey40gzw 11 18 , , , cord-337137-0ey40gzw 11 19 causes cause VBZ cord-337137-0ey40gzw 11 20 illness illness NN cord-337137-0ey40gzw 11 21 in in IN cord-337137-0ey40gzw 11 22 humans human NNS cord-337137-0ey40gzw 11 23 remain remain VBP cord-337137-0ey40gzw 11 24 unanswered unanswered JJ cord-337137-0ey40gzw 11 25 . . . cord-337137-0ey40gzw 12 1 The the DT cord-337137-0ey40gzw 12 2 pathology pathology NN cord-337137-0ey40gzw 12 3 of of IN cord-337137-0ey40gzw 12 4 fatal fatal JJ cord-337137-0ey40gzw 12 5 cases case NNS cord-337137-0ey40gzw 12 6 of of IN cord-337137-0ey40gzw 12 7 SARS SARS NNP cord-337137-0ey40gzw 12 8 is be VBZ cord-337137-0ey40gzw 12 9 dominated dominate VBN cord-337137-0ey40gzw 12 10 by by IN cord-337137-0ey40gzw 12 11 diffuse diffuse JJ cord-337137-0ey40gzw 12 12 alveolar alveolar JJ cord-337137-0ey40gzw 12 13 damage damage NN cord-337137-0ey40gzw 12 14 . . . cord-337137-0ey40gzw 13 1 Specific specific JJ cord-337137-0ey40gzw 13 2 histological histological JJ cord-337137-0ey40gzw 13 3 changes change NNS cord-337137-0ey40gzw 13 4 are be VBP cord-337137-0ey40gzw 13 5 not not RB cord-337137-0ey40gzw 13 6 detected detect VBN cord-337137-0ey40gzw 13 7 in in IN cord-337137-0ey40gzw 13 8 other other JJ cord-337137-0ey40gzw 13 9 organs organ NNS cord-337137-0ey40gzw 13 10 . . . cord-337137-0ey40gzw 14 1 These these DT cord-337137-0ey40gzw 14 2 contrast contrast NN cord-337137-0ey40gzw 14 3 remarkably remarkably RB cord-337137-0ey40gzw 14 4 with with IN cord-337137-0ey40gzw 14 5 the the DT cord-337137-0ey40gzw 14 6 clinical clinical JJ cord-337137-0ey40gzw 14 7 picture picture NN cord-337137-0ey40gzw 14 8 , , , cord-337137-0ey40gzw 14 9 in in IN cord-337137-0ey40gzw 14 10 which which WDT cord-337137-0ey40gzw 14 11 there there EX cord-337137-0ey40gzw 14 12 are be VBP cord-337137-0ey40gzw 14 13 apparent apparent JJ cord-337137-0ey40gzw 14 14 manifestations manifestation NNS cord-337137-0ey40gzw 14 15 in in IN cord-337137-0ey40gzw 14 16 multiple multiple JJ cord-337137-0ey40gzw 14 17 organs organ NNS cord-337137-0ey40gzw 14 18 . . . cord-337137-0ey40gzw 15 1 Both both DT cord-337137-0ey40gzw 15 2 pathogen pathogen NN cord-337137-0ey40gzw 15 3 and and CC cord-337137-0ey40gzw 15 4 host host NN cord-337137-0ey40gzw 15 5 factors factor NNS cord-337137-0ey40gzw 15 6 are be VBP cord-337137-0ey40gzw 15 7 important important JJ cord-337137-0ey40gzw 15 8 in in IN cord-337137-0ey40gzw 15 9 the the DT cord-337137-0ey40gzw 15 10 pathogenesis pathogenesis NN cord-337137-0ey40gzw 15 11 of of IN cord-337137-0ey40gzw 15 12 SARS SARS NNP cord-337137-0ey40gzw 15 13 . . . cord-337137-0ey40gzw 16 1 The the DT cord-337137-0ey40gzw 16 2 choice choice NN cord-337137-0ey40gzw 16 3 of of IN cord-337137-0ey40gzw 16 4 specific specific JJ cord-337137-0ey40gzw 16 5 receptors receptor NNS cord-337137-0ey40gzw 16 6 and and CC cord-337137-0ey40gzw 16 7 the the DT cord-337137-0ey40gzw 16 8 unique unique JJ cord-337137-0ey40gzw 16 9 genome genome NN cord-337137-0ey40gzw 16 10 of of IN cord-337137-0ey40gzw 16 11 the the DT cord-337137-0ey40gzw 16 12 SARS‐CoV sars‐cov NN cord-337137-0ey40gzw 16 13 are be VBP cord-337137-0ey40gzw 16 14 important important JJ cord-337137-0ey40gzw 16 15 elements element NNS cord-337137-0ey40gzw 16 16 in in IN cord-337137-0ey40gzw 16 17 understanding understand VBG cord-337137-0ey40gzw 16 18 the the DT cord-337137-0ey40gzw 16 19 biology biology NN cord-337137-0ey40gzw 16 20 of of IN cord-337137-0ey40gzw 16 21 the the DT cord-337137-0ey40gzw 16 22 pathogen pathogen NN cord-337137-0ey40gzw 16 23 . . . cord-337137-0ey40gzw 17 1 For for IN cord-337137-0ey40gzw 17 2 the the DT cord-337137-0ey40gzw 17 3 host host NN cord-337137-0ey40gzw 17 4 cells cell NNS cord-337137-0ey40gzw 17 5 , , , cord-337137-0ey40gzw 17 6 the the DT cord-337137-0ey40gzw 17 7 outcome outcome NN cord-337137-0ey40gzw 17 8 of of IN cord-337137-0ey40gzw 17 9 SARS‐CoV sars‐cov NN cord-337137-0ey40gzw 17 10 infection infection NN cord-337137-0ey40gzw 17 11 , , , cord-337137-0ey40gzw 17 12 whether whether IN cord-337137-0ey40gzw 17 13 there there EX cord-337137-0ey40gzw 17 14 are be VBP cord-337137-0ey40gzw 17 15 cytopathic cytopathic JJ cord-337137-0ey40gzw 17 16 effects effect NNS cord-337137-0ey40gzw 17 17 or or CC cord-337137-0ey40gzw 17 18 not not RB cord-337137-0ey40gzw 17 19 , , , cord-337137-0ey40gzw 17 20 depends depend VBZ cord-337137-0ey40gzw 17 21 on on IN cord-337137-0ey40gzw 17 22 the the DT cord-337137-0ey40gzw 17 23 cell cell NN cord-337137-0ey40gzw 17 24 types type NNS cord-337137-0ey40gzw 17 25 that that WDT cord-337137-0ey40gzw 17 26 are be VBP cord-337137-0ey40gzw 17 27 infected infect VBN cord-337137-0ey40gzw 17 28 . . . cord-337137-0ey40gzw 18 1 At at IN cord-337137-0ey40gzw 18 2 the the DT cord-337137-0ey40gzw 18 3 whole‐body whole‐body JJ cord-337137-0ey40gzw 18 4 level level NN cord-337137-0ey40gzw 18 5 , , , cord-337137-0ey40gzw 18 6 immune‐mediated immune‐mediated JJ cord-337137-0ey40gzw 18 7 damage damage NN cord-337137-0ey40gzw 18 8 , , , cord-337137-0ey40gzw 18 9 due due IN cord-337137-0ey40gzw 18 10 to to IN cord-337137-0ey40gzw 18 11 activation activation NN cord-337137-0ey40gzw 18 12 of of IN cord-337137-0ey40gzw 18 13 cytokines cytokine NNS cord-337137-0ey40gzw 18 14 and/or and/or CC cord-337137-0ey40gzw 18 15 chemokines chemokine NNS cord-337137-0ey40gzw 18 16 and and CC cord-337137-0ey40gzw 18 17 , , , cord-337137-0ey40gzw 18 18 perhaps perhaps RB cord-337137-0ey40gzw 18 19 , , , cord-337137-0ey40gzw 18 20 autoimmunity autoimmunity NN cord-337137-0ey40gzw 18 21 , , , cord-337137-0ey40gzw 18 22 may may MD cord-337137-0ey40gzw 18 23 play play VB cord-337137-0ey40gzw 18 24 key key JJ cord-337137-0ey40gzw 18 25 roles role NNS cord-337137-0ey40gzw 18 26 in in IN cord-337137-0ey40gzw 18 27 the the DT cord-337137-0ey40gzw 18 28 clinical clinical JJ cord-337137-0ey40gzw 18 29 and and CC cord-337137-0ey40gzw 18 30 pathological pathological JJ cord-337137-0ey40gzw 18 31 features feature NNS cord-337137-0ey40gzw 18 32 of of IN cord-337137-0ey40gzw 18 33 SARS SARS NNP cord-337137-0ey40gzw 18 34 . . . cord-337137-0ey40gzw 19 1 Continued continued JJ cord-337137-0ey40gzw 19 2 research research NN cord-337137-0ey40gzw 19 3 is be VBZ cord-337137-0ey40gzw 19 4 still still RB cord-337137-0ey40gzw 19 5 required require VBN cord-337137-0ey40gzw 19 6 to to TO cord-337137-0ey40gzw 19 7 determine determine VB cord-337137-0ey40gzw 19 8 the the DT cord-337137-0ey40gzw 19 9 pathogenetic pathogenetic JJ cord-337137-0ey40gzw 19 10 mechanisms mechanism NNS cord-337137-0ey40gzw 19 11 involved involve VBN cord-337137-0ey40gzw 19 12 and and CC cord-337137-0ey40gzw 19 13 to to TO cord-337137-0ey40gzw 19 14 combat combat VB cord-337137-0ey40gzw 19 15 this this DT cord-337137-0ey40gzw 19 16 new new JJ cord-337137-0ey40gzw 19 17 emerging emerge VBG cord-337137-0ey40gzw 19 18 human human JJ cord-337137-0ey40gzw 19 19 infectious infectious JJ cord-337137-0ey40gzw 19 20 disease disease NN cord-337137-0ey40gzw 19 21 . . . cord-337137-0ey40gzw 20 1 Copyright copyright NN cord-337137-0ey40gzw 20 2 © © NNP cord-337137-0ey40gzw 20 3 2006 2006 CD cord-337137-0ey40gzw 20 4 Pathological Pathological NNP cord-337137-0ey40gzw 20 5 Society Society NNP cord-337137-0ey40gzw 20 6 of of IN cord-337137-0ey40gzw 20 7 Great Great NNP cord-337137-0ey40gzw 20 8 Britain Britain NNP cord-337137-0ey40gzw 20 9 and and CC cord-337137-0ey40gzw 20 10 Ireland Ireland NNP cord-337137-0ey40gzw 20 11 . . . cord-337137-0ey40gzw 21 1 Published publish VBN cord-337137-0ey40gzw 21 2 by by IN cord-337137-0ey40gzw 21 3 John John NNP cord-337137-0ey40gzw 21 4 Wiley Wiley NNP cord-337137-0ey40gzw 21 5 & & CC cord-337137-0ey40gzw 21 6 Sons Sons NNP cord-337137-0ey40gzw 21 7 , , , cord-337137-0ey40gzw 22 1 Ltd. Ltd. NNP cord-337137-0ey40gzw 22 2 Severe severe JJ cord-337137-0ey40gzw 22 3 acute acute JJ cord-337137-0ey40gzw 22 4 respiratory respiratory JJ cord-337137-0ey40gzw 22 5 syndrome syndrome NN cord-337137-0ey40gzw 22 6 ( ( -LRB- cord-337137-0ey40gzw 22 7 SARS SARS NNP cord-337137-0ey40gzw 22 8 ) ) -RRB- cord-337137-0ey40gzw 22 9 is be VBZ cord-337137-0ey40gzw 22 10 a a DT cord-337137-0ey40gzw 22 11 new new JJ cord-337137-0ey40gzw 22 12 viral viral JJ cord-337137-0ey40gzw 22 13 disease disease NN cord-337137-0ey40gzw 22 14 caused cause VBN cord-337137-0ey40gzw 22 15 by by IN cord-337137-0ey40gzw 22 16 a a DT cord-337137-0ey40gzw 22 17 novel novel JJ cord-337137-0ey40gzw 22 18 coronavirus coronavirus NN cord-337137-0ey40gzw 22 19 , , , cord-337137-0ey40gzw 22 20 SARS SARS NNP cord-337137-0ey40gzw 22 21 - - HYPH cord-337137-0ey40gzw 22 22 CoV CoV NNP cord-337137-0ey40gzw 22 23 ( ( -LRB- cord-337137-0ey40gzw 22 24 Figure figure NN cord-337137-0ey40gzw 22 25 1 1 CD cord-337137-0ey40gzw 22 26 ) ) -RRB- cord-337137-0ey40gzw 22 27 [ [ -LRB- cord-337137-0ey40gzw 22 28 1 1 CD cord-337137-0ey40gzw 22 29 , , , cord-337137-0ey40gzw 22 30 2 2 CD cord-337137-0ey40gzw 22 31 ] ] -RRB- cord-337137-0ey40gzw 22 32 . . . cord-337137-0ey40gzw 23 1 The the DT cord-337137-0ey40gzw 23 2 saga saga NN cord-337137-0ey40gzw 23 3 of of IN cord-337137-0ey40gzw 23 4 SARS SARS NNP cord-337137-0ey40gzw 23 5 has have VBZ cord-337137-0ey40gzw 23 6 officially officially RB cord-337137-0ey40gzw 23 7 come come VBN cord-337137-0ey40gzw 23 8 to to IN cord-337137-0ey40gzw 23 9 an an DT cord-337137-0ey40gzw 23 10 end end NN cord-337137-0ey40gzw 23 11 , , , cord-337137-0ey40gzw 23 12 as as IN cord-337137-0ey40gzw 23 13 no no DT cord-337137-0ey40gzw 23 14 more more RBR cord-337137-0ey40gzw 23 15 new new JJ cord-337137-0ey40gzw 23 16 cases case NNS cord-337137-0ey40gzw 23 17 have have VBP cord-337137-0ey40gzw 23 18 been be VBN cord-337137-0ey40gzw 23 19 reported report VBN cord-337137-0ey40gzw 23 20 since since IN cord-337137-0ey40gzw 23 21 2004 2004 CD cord-337137-0ey40gzw 23 22 . . . cord-337137-0ey40gzw 24 1 Many many JJ cord-337137-0ey40gzw 24 2 questions question NNS cord-337137-0ey40gzw 24 3 , , , cord-337137-0ey40gzw 24 4 particularly particularly RB cord-337137-0ey40gzw 24 5 those those DT cord-337137-0ey40gzw 24 6 related relate VBN cord-337137-0ey40gzw 24 7 to to IN cord-337137-0ey40gzw 24 8 how how WRB cord-337137-0ey40gzw 24 9 SARS SARS NNP cord-337137-0ey40gzw 24 10 - - HYPH cord-337137-0ey40gzw 24 11 CoV CoV NNP cord-337137-0ey40gzw 24 12 causes cause VBZ cord-337137-0ey40gzw 24 13 disease disease NN cord-337137-0ey40gzw 24 14 , , , cord-337137-0ey40gzw 24 15 however however RB cord-337137-0ey40gzw 24 16 , , , cord-337137-0ey40gzw 24 17 remain remain VBP cord-337137-0ey40gzw 24 18 unanswered unanswered JJ cord-337137-0ey40gzw 24 19 . . . cord-337137-0ey40gzw 25 1 The the DT cord-337137-0ey40gzw 25 2 disease disease NN cord-337137-0ey40gzw 25 3 caused cause VBN cord-337137-0ey40gzw 25 4 by by IN cord-337137-0ey40gzw 25 5 SARS SARS NNP cord-337137-0ey40gzw 25 6 - - HYPH cord-337137-0ey40gzw 25 7 CoV CoV NNP cord-337137-0ey40gzw 25 8 differs differ VBZ cord-337137-0ey40gzw 25 9 from from IN cord-337137-0ey40gzw 25 10 the the DT cord-337137-0ey40gzw 25 11 diseases disease NNS cord-337137-0ey40gzw 25 12 caused cause VBN cord-337137-0ey40gzw 25 13 by by IN cord-337137-0ey40gzw 25 14 the the DT cord-337137-0ey40gzw 25 15 previously previously RB cord-337137-0ey40gzw 25 16 known know VBN cord-337137-0ey40gzw 25 17 human human JJ cord-337137-0ey40gzw 25 18 coronaviruses coronaviruse NNS cord-337137-0ey40gzw 25 19 , , , cord-337137-0ey40gzw 25 20 229E 229e CD cord-337137-0ey40gzw 25 21 and and CC cord-337137-0ey40gzw 25 22 OC43 OC43 NNP cord-337137-0ey40gzw 25 23 . . . cord-337137-0ey40gzw 26 1 SARS SARS NNP cord-337137-0ey40gzw 26 2 - - HYPH cord-337137-0ey40gzw 26 3 CoV CoV NNP cord-337137-0ey40gzw 26 4 infection infection NN cord-337137-0ey40gzw 26 5 results result NNS cord-337137-0ey40gzw 26 6 in in IN cord-337137-0ey40gzw 26 7 severe severe JJ cord-337137-0ey40gzw 26 8 and and CC cord-337137-0ey40gzw 26 9 potentially potentially RB cord-337137-0ey40gzw 26 10 fatal fatal JJ cord-337137-0ey40gzw 26 11 lung lung NN cord-337137-0ey40gzw 26 12 disease disease NN cord-337137-0ey40gzw 26 13 [ [ -LRB- cord-337137-0ey40gzw 26 14 1 1 CD cord-337137-0ey40gzw 26 15 , , , cord-337137-0ey40gzw 26 16 2 2 CD cord-337137-0ey40gzw 26 17 ] ] -RRB- cord-337137-0ey40gzw 26 18 . . . cord-337137-0ey40gzw 27 1 Although although IN cord-337137-0ey40gzw 27 2 the the DT cord-337137-0ey40gzw 27 3 majority majority NN cord-337137-0ey40gzw 27 4 of of IN cord-337137-0ey40gzw 27 5 patients patient NNS cord-337137-0ey40gzw 27 6 recovered recover VBN cord-337137-0ey40gzw 27 7 after after IN cord-337137-0ey40gzw 27 8 1 1 CD cord-337137-0ey40gzw 27 9 - - SYM cord-337137-0ey40gzw 27 10 2 2 CD cord-337137-0ey40gzw 27 11 weeks week NNS cord-337137-0ey40gzw 27 12 of of IN cord-337137-0ey40gzw 27 13 debilitating debilitate VBG cord-337137-0ey40gzw 27 14 febrile febrile JJ cord-337137-0ey40gzw 27 15 illness illness NN cord-337137-0ey40gzw 27 16 , , , cord-337137-0ey40gzw 27 17 a a DT cord-337137-0ey40gzw 27 18 substantial substantial JJ cord-337137-0ey40gzw 27 19 proportion proportion NN cord-337137-0ey40gzw 27 20 ( ( -LRB- cord-337137-0ey40gzw 27 21 up up IN cord-337137-0ey40gzw 27 22 to to IN cord-337137-0ey40gzw 27 23 one one CD cord-337137-0ey40gzw 27 24 - - HYPH cord-337137-0ey40gzw 27 25 third third NN cord-337137-0ey40gzw 27 26 ) ) -RRB- cord-337137-0ey40gzw 27 27 developed develop VBD cord-337137-0ey40gzw 27 28 severe severe JJ cord-337137-0ey40gzw 27 29 inflammation inflammation NN cord-337137-0ey40gzw 27 30 of of IN cord-337137-0ey40gzw 27 31 the the DT cord-337137-0ey40gzw 27 32 lung lung NN cord-337137-0ey40gzw 27 33 , , , cord-337137-0ey40gzw 27 34 requiring require VBG cord-337137-0ey40gzw 27 35 ventilator ventilator NN cord-337137-0ey40gzw 27 36 support support NN cord-337137-0ey40gzw 27 37 and and CC cord-337137-0ey40gzw 27 38 intensive intensive JJ cord-337137-0ey40gzw 27 39 care care NN cord-337137-0ey40gzw 27 40 . . . cord-337137-0ey40gzw 28 1 Many many JJ cord-337137-0ey40gzw 28 2 patients patient NNS cord-337137-0ey40gzw 28 3 in in IN cord-337137-0ey40gzw 28 4 this this DT cord-337137-0ey40gzw 28 5 group group NN cord-337137-0ey40gzw 28 6 deteriorated deteriorate VBD cord-337137-0ey40gzw 28 7 into into IN cord-337137-0ey40gzw 28 8 acute acute JJ cord-337137-0ey40gzw 28 9 respiratory respiratory JJ cord-337137-0ey40gzw 28 10 distress distress NN cord-337137-0ey40gzw 28 11 syndrome syndrome NN cord-337137-0ey40gzw 28 12 ( ( -LRB- cord-337137-0ey40gzw 28 13 ARDS ARDS NNP cord-337137-0ey40gzw 28 14 ) ) -RRB- cord-337137-0ey40gzw 28 15 . . . cord-337137-0ey40gzw 29 1 The the DT cord-337137-0ey40gzw 29 2 mortality mortality NN cord-337137-0ey40gzw 29 3 of of IN cord-337137-0ey40gzw 29 4 this this DT cord-337137-0ey40gzw 29 5 group group NN cord-337137-0ey40gzw 29 6 of of IN cord-337137-0ey40gzw 29 7 patients patient NNS cord-337137-0ey40gzw 29 8 is be VBZ cord-337137-0ey40gzw 29 9 high high JJ cord-337137-0ey40gzw 29 10 [ [ -LRB- cord-337137-0ey40gzw 29 11 3 3 CD cord-337137-0ey40gzw 29 12 ] ] -RRB- cord-337137-0ey40gzw 29 13 . . . cord-337137-0ey40gzw 30 1 Manifestations manifestation NNS cord-337137-0ey40gzw 30 2 in in IN cord-337137-0ey40gzw 30 3 other other JJ cord-337137-0ey40gzw 30 4 organ organ NN cord-337137-0ey40gzw 30 5 systems system NNS cord-337137-0ey40gzw 30 6 are be VBP cord-337137-0ey40gzw 30 7 characteristic characteristic JJ cord-337137-0ey40gzw 30 8 . . . cord-337137-0ey40gzw 31 1 Lymphopenia Lymphopenia NNP cord-337137-0ey40gzw 31 2 [ [ -LRB- cord-337137-0ey40gzw 31 3 4 4 CD cord-337137-0ey40gzw 31 4 ] ] -RRB- cord-337137-0ey40gzw 31 5 , , , cord-337137-0ey40gzw 31 6 gastrointestinal gastrointestinal JJ cord-337137-0ey40gzw 31 7 symptoms symptom NNS cord-337137-0ey40gzw 31 8 [ [ -LRB- cord-337137-0ey40gzw 31 9 5 5 CD cord-337137-0ey40gzw 31 10 ] ] -RRB- cord-337137-0ey40gzw 31 11 , , , cord-337137-0ey40gzw 31 12 impaired impaired JJ cord-337137-0ey40gzw 31 13 liver liver NN cord-337137-0ey40gzw 31 14 function function NN cord-337137-0ey40gzw 31 15 [ [ -LRB- cord-337137-0ey40gzw 31 16 6 6 CD cord-337137-0ey40gzw 31 17 , , , cord-337137-0ey40gzw 31 18 7 7 CD cord-337137-0ey40gzw 31 19 ] ] -RRB- cord-337137-0ey40gzw 31 20 , , , cord-337137-0ey40gzw 31 21 and and CC cord-337137-0ey40gzw 31 22 impaired impaired JJ cord-337137-0ey40gzw 31 23 renal renal JJ cord-337137-0ey40gzw 31 24 function function NN cord-337137-0ey40gzw 31 25 [ [ -LRB- cord-337137-0ey40gzw 32 1 8 8 LS cord-337137-0ey40gzw 32 2 ] ] -RRB- cord-337137-0ey40gzw 32 3 are be VBP cord-337137-0ey40gzw 32 4 common common JJ cord-337137-0ey40gzw 32 5 . . . cord-337137-0ey40gzw 33 1 The the DT cord-337137-0ey40gzw 33 2 possibility possibility NN cord-337137-0ey40gzw 33 3 of of IN cord-337137-0ey40gzw 33 4 viral viral JJ cord-337137-0ey40gzw 33 5 infection infection NN cord-337137-0ey40gzw 33 6 in in IN cord-337137-0ey40gzw 33 7 multiple multiple JJ cord-337137-0ey40gzw 33 8 organs organ NNS cord-337137-0ey40gzw 33 9 has have VBZ cord-337137-0ey40gzw 33 10 been be VBN cord-337137-0ey40gzw 33 11 raised raise VBN cord-337137-0ey40gzw 33 12 and and CC cord-337137-0ey40gzw 33 13 viral viral JJ cord-337137-0ey40gzw 33 14 replication replication NN cord-337137-0ey40gzw 33 15 in in IN cord-337137-0ey40gzw 33 16 the the DT cord-337137-0ey40gzw 33 17 lung lung NN cord-337137-0ey40gzw 33 18 , , , cord-337137-0ey40gzw 33 19 kidney kidney NN cord-337137-0ey40gzw 33 20 , , , cord-337137-0ey40gzw 33 21 and and CC cord-337137-0ey40gzw 33 22 gastrointestinal gastrointestinal JJ cord-337137-0ey40gzw 33 23 tract tract NN cord-337137-0ey40gzw 33 24 was be VBD cord-337137-0ey40gzw 33 25 reported report VBN cord-337137-0ey40gzw 33 26 [ [ -LRB- cord-337137-0ey40gzw 33 27 9 9 CD cord-337137-0ey40gzw 33 28 , , , cord-337137-0ey40gzw 33 29 10 10 CD cord-337137-0ey40gzw 33 30 ] ] -RRB- cord-337137-0ey40gzw 33 31 . . . cord-337137-0ey40gzw 34 1 In in IN cord-337137-0ey40gzw 34 2 addition addition NN cord-337137-0ey40gzw 34 3 , , , cord-337137-0ey40gzw 34 4 prolonged prolong VBN cord-337137-0ey40gzw 34 5 shedding shedding NN cord-337137-0ey40gzw 34 6 of of IN cord-337137-0ey40gzw 34 7 virus virus NN cord-337137-0ey40gzw 34 8 was be VBD cord-337137-0ey40gzw 34 9 found find VBN cord-337137-0ey40gzw 34 10 in in IN cord-337137-0ey40gzw 34 11 some some DT cord-337137-0ey40gzw 34 12 convalescent convalescent JJ cord-337137-0ey40gzw 34 13 patients patient NNS cord-337137-0ey40gzw 34 14 [ [ -LRB- cord-337137-0ey40gzw 34 15 11 11 CD cord-337137-0ey40gzw 34 16 ] ] -RRB- cord-337137-0ey40gzw 34 17 . . . cord-337137-0ey40gzw 35 1 However however RB cord-337137-0ey40gzw 35 2 , , , cord-337137-0ey40gzw 35 3 chronic chronic JJ cord-337137-0ey40gzw 35 4 infection infection NN cord-337137-0ey40gzw 35 5 by by IN cord-337137-0ey40gzw 35 6 SARS SARS NNP cord-337137-0ey40gzw 35 7 - - HYPH cord-337137-0ey40gzw 35 8 CoV CoV NNP cord-337137-0ey40gzw 35 9 has have VBZ cord-337137-0ey40gzw 35 10 not not RB cord-337137-0ey40gzw 35 11 , , , cord-337137-0ey40gzw 35 12 to to IN cord-337137-0ey40gzw 35 13 date date NN cord-337137-0ey40gzw 35 14 , , , cord-337137-0ey40gzw 35 15 been be VBN cord-337137-0ey40gzw 35 16 documented document VBN cord-337137-0ey40gzw 35 17 in in IN cord-337137-0ey40gzw 35 18 humans human NNS cord-337137-0ey40gzw 35 19 . . . cord-337137-0ey40gzw 36 1 Moreover moreover RB cord-337137-0ey40gzw 36 2 , , , cord-337137-0ey40gzw 36 3 asymptomatic asymptomatic JJ cord-337137-0ey40gzw 36 4 carriage carriage NN cord-337137-0ey40gzw 36 5 of of IN cord-337137-0ey40gzw 36 6 SARS SARS NNP cord-337137-0ey40gzw 36 7 - - HYPH cord-337137-0ey40gzw 36 8 CoV CoV NNP cord-337137-0ey40gzw 36 9 is be VBZ cord-337137-0ey40gzw 36 10 rare rare JJ cord-337137-0ey40gzw 36 11 [ [ -LRB- cord-337137-0ey40gzw 36 12 12 12 CD cord-337137-0ey40gzw 36 13 ] ] -RRB- cord-337137-0ey40gzw 36 14 . . . cord-337137-0ey40gzw 37 1 There there EX cord-337137-0ey40gzw 37 2 are be VBP cord-337137-0ey40gzw 37 3 significant significant JJ cord-337137-0ey40gzw 37 4 age age NN cord-337137-0ey40gzw 37 5 differences difference NNS cord-337137-0ey40gzw 37 6 in in IN cord-337137-0ey40gzw 37 7 the the DT cord-337137-0ey40gzw 37 8 prognosis prognosis NN cord-337137-0ey40gzw 37 9 of of IN cord-337137-0ey40gzw 37 10 SARS SARS NNP cord-337137-0ey40gzw 37 11 . . . cord-337137-0ey40gzw 38 1 Children child NNS cord-337137-0ey40gzw 38 2 have have VBP cord-337137-0ey40gzw 38 3 a a DT cord-337137-0ey40gzw 38 4 good good JJ cord-337137-0ey40gzw 38 5 prognosis prognosis NN cord-337137-0ey40gzw 38 6 [ [ -LRB- cord-337137-0ey40gzw 38 7 13 13 CD cord-337137-0ey40gzw 38 8 ] ] -RRB- cord-337137-0ey40gzw 38 9 , , , cord-337137-0ey40gzw 38 10 while while IN cord-337137-0ey40gzw 38 11 elderly elderly JJ cord-337137-0ey40gzw 38 12 patients patient NNS cord-337137-0ey40gzw 38 13 with with IN cord-337137-0ey40gzw 38 14 chronic chronic JJ cord-337137-0ey40gzw 38 15 illnesses illness NNS cord-337137-0ey40gzw 38 16 fare fare VBP cord-337137-0ey40gzw 38 17 badly badly RB cord-337137-0ey40gzw 38 18 . . . cord-337137-0ey40gzw 39 1 SARS SARS NNP cord-337137-0ey40gzw 39 2 is be VBZ cord-337137-0ey40gzw 39 3 predominantly predominantly RB cord-337137-0ey40gzw 39 4 a a DT cord-337137-0ey40gzw 39 5 lower low JJR cord-337137-0ey40gzw 39 6 respiratory respiratory JJ cord-337137-0ey40gzw 39 7 tract tract NN cord-337137-0ey40gzw 39 8 disease disease NN cord-337137-0ey40gzw 39 9 , , , cord-337137-0ey40gzw 39 10 yet yet CC cord-337137-0ey40gzw 39 11 the the DT cord-337137-0ey40gzw 39 12 most most RBS cord-337137-0ey40gzw 39 13 consistent consistent JJ cord-337137-0ey40gzw 39 14 and and CC cord-337137-0ey40gzw 39 15 powerful powerful JJ cord-337137-0ey40gzw 39 16 prognostic prognostic JJ cord-337137-0ey40gzw 39 17 indicator indicator NN cord-337137-0ey40gzw 39 18 reported report VBD cord-337137-0ey40gzw 39 19 so so RB cord-337137-0ey40gzw 39 20 far far RB cord-337137-0ey40gzw 39 21 is be VBZ cord-337137-0ey40gzw 39 22 blood blood NN cord-337137-0ey40gzw 39 23 lactate lactate NN cord-337137-0ey40gzw 39 24 dehydrogenase dehydrogenase NN cord-337137-0ey40gzw 39 25 ( ( -LRB- cord-337137-0ey40gzw 39 26 LDH LDH NNP cord-337137-0ey40gzw 39 27 ) ) -RRB- cord-337137-0ey40gzw 39 28 concentration concentration NN cord-337137-0ey40gzw 39 29 [ [ -LRB- cord-337137-0ey40gzw 39 30 1 1 CD cord-337137-0ey40gzw 39 31 ] ] -RRB- cord-337137-0ey40gzw 39 32 , , , cord-337137-0ey40gzw 39 33 which which WDT cord-337137-0ey40gzw 39 34 is be VBZ cord-337137-0ey40gzw 39 35 most most RBS cord-337137-0ey40gzw 39 36 likely likely RB cord-337137-0ey40gzw 39 37 a a DT cord-337137-0ey40gzw 39 38 surrogate surrogate JJ cord-337137-0ey40gzw 39 39 indicator indicator NN cord-337137-0ey40gzw 39 40 and and CC cord-337137-0ey40gzw 39 41 may may MD cord-337137-0ey40gzw 39 42 reflect reflect VB cord-337137-0ey40gzw 39 43 the the DT cord-337137-0ey40gzw 39 44 extent extent NN cord-337137-0ey40gzw 39 45 of of IN cord-337137-0ey40gzw 39 46 ongoing ongoing JJ cord-337137-0ey40gzw 39 47 tissue tissue NN cord-337137-0ey40gzw 39 48 damage damage NN cord-337137-0ey40gzw 39 49 . . . cord-337137-0ey40gzw 40 1 Both both DT cord-337137-0ey40gzw 40 2 pathogen pathogen NN cord-337137-0ey40gzw 40 3 and and CC cord-337137-0ey40gzw 40 4 host host NN cord-337137-0ey40gzw 40 5 factors factor NNS cord-337137-0ey40gzw 40 6 are be VBP cord-337137-0ey40gzw 40 7 important important JJ cord-337137-0ey40gzw 40 8 for for IN cord-337137-0ey40gzw 40 9 the the DT cord-337137-0ey40gzw 40 10 progression progression NN cord-337137-0ey40gzw 40 11 of of IN cord-337137-0ey40gzw 40 12 an an DT cord-337137-0ey40gzw 40 13 infection infection NN cord-337137-0ey40gzw 40 14 . . . cord-337137-0ey40gzw 41 1 Here here RB cord-337137-0ey40gzw 41 2 , , , cord-337137-0ey40gzw 41 3 we -PRON- PRP cord-337137-0ey40gzw 41 4 review review VBP cord-337137-0ey40gzw 41 5 the the DT cord-337137-0ey40gzw 41 6 pathology pathology NN cord-337137-0ey40gzw 41 7 of of IN cord-337137-0ey40gzw 41 8 SARS SARS NNP cord-337137-0ey40gzw 41 9 infection infection NN cord-337137-0ey40gzw 41 10 . . . cord-337137-0ey40gzw 42 1 Specific specific JJ cord-337137-0ey40gzw 42 2 features feature NNS cord-337137-0ey40gzw 42 3 of of IN cord-337137-0ey40gzw 42 4 the the DT cord-337137-0ey40gzw 42 5 pathogen pathogen NN cord-337137-0ey40gzw 42 6 SARS SARS NNP cord-337137-0ey40gzw 42 7 - - HYPH cord-337137-0ey40gzw 42 8 CoV CoV NNP cord-337137-0ey40gzw 42 9 itself -PRON- PRP cord-337137-0ey40gzw 42 10 are be VBP cord-337137-0ey40gzw 42 11 then then RB cord-337137-0ey40gzw 42 12 addressed address VBN cord-337137-0ey40gzw 42 13 . . . cord-337137-0ey40gzw 43 1 Finally finally RB cord-337137-0ey40gzw 43 2 , , , cord-337137-0ey40gzw 43 3 host host NN cord-337137-0ey40gzw 43 4 factors factor NNS cord-337137-0ey40gzw 43 5 , , , cord-337137-0ey40gzw 43 6 particularly particularly RB cord-337137-0ey40gzw 43 7 an an DT cord-337137-0ey40gzw 43 8 emerging emerge VBG cord-337137-0ey40gzw 43 9 understanding understanding NN cord-337137-0ey40gzw 43 10 of of IN cord-337137-0ey40gzw 43 11 immunological immunological JJ cord-337137-0ey40gzw 43 12 and and CC cord-337137-0ey40gzw 43 13 inflammatory inflammatory JJ cord-337137-0ey40gzw 43 14 responses response NNS cord-337137-0ey40gzw 43 15 to to IN cord-337137-0ey40gzw 43 16 SARS SARS NNP cord-337137-0ey40gzw 43 17 - - HYPH cord-337137-0ey40gzw 43 18 CoV CoV NNP cord-337137-0ey40gzw 43 19 infection infection NN cord-337137-0ey40gzw 43 20 , , , cord-337137-0ey40gzw 43 21 are be VBP cord-337137-0ey40gzw 43 22 discussed discuss VBN cord-337137-0ey40gzw 43 23 . . . cord-337137-0ey40gzw 44 1 Virus virus NN cord-337137-0ey40gzw 44 2 particles particle NNS cord-337137-0ey40gzw 44 3 can can MD cord-337137-0ey40gzw 44 4 also also RB cord-337137-0ey40gzw 44 5 be be VB cord-337137-0ey40gzw 44 6 seen see VBN cord-337137-0ey40gzw 44 7 budding bud VBG cord-337137-0ey40gzw 44 8 through through IN cord-337137-0ey40gzw 44 9 the the DT cord-337137-0ey40gzw 44 10 cytoplasmic cytoplasmic JJ cord-337137-0ey40gzw 44 11 membrane membrane NN cord-337137-0ey40gzw 44 12 ( ( -LRB- cord-337137-0ey40gzw 44 13 B b NN cord-337137-0ey40gzw 44 14 ) ) -RRB- cord-337137-0ey40gzw 44 15 . . . cord-337137-0ey40gzw 45 1 Each each DT cord-337137-0ey40gzw 45 2 virion virion NN cord-337137-0ey40gzw 45 3 particle particle NN cord-337137-0ey40gzw 45 4 is be VBZ cord-337137-0ey40gzw 45 5 60 60 CD cord-337137-0ey40gzw 45 6 - - SYM cord-337137-0ey40gzw 45 7 90 90 CD cord-337137-0ey40gzw 45 8 nm nm NN cord-337137-0ey40gzw 45 9 in in IN cord-337137-0ey40gzw 45 10 size size NN cord-337137-0ey40gzw 45 11 by by IN cord-337137-0ey40gzw 45 12 transmission transmission NN cord-337137-0ey40gzw 45 13 electron electron NN cord-337137-0ey40gzw 45 14 microscopy microscopy NN cord-337137-0ey40gzw 45 15 and and CC cord-337137-0ey40gzw 45 16 is be VBZ cord-337137-0ey40gzw 45 17 characterized characterize VBN cord-337137-0ey40gzw 45 18 by by IN cord-337137-0ey40gzw 45 19 the the DT cord-337137-0ey40gzw 45 20 numerous numerous JJ cord-337137-0ey40gzw 45 21 club club NN cord-337137-0ey40gzw 45 22 - - HYPH cord-337137-0ey40gzw 45 23 shaped shape VBN cord-337137-0ey40gzw 45 24 projections projection NNS cord-337137-0ey40gzw 45 25 on on IN cord-337137-0ey40gzw 45 26 the the DT cord-337137-0ey40gzw 45 27 outside outside NN cord-337137-0ey40gzw 45 28 , , , cord-337137-0ey40gzw 45 29 a a DT cord-337137-0ey40gzw 45 30 ring ring NN cord-337137-0ey40gzw 45 31 beneath beneath IN cord-337137-0ey40gzw 45 32 the the DT cord-337137-0ey40gzw 45 33 envelope envelope NN cord-337137-0ey40gzw 45 34 , , , cord-337137-0ey40gzw 45 35 and and CC cord-337137-0ey40gzw 45 36 an an DT cord-337137-0ey40gzw 45 37 electron electron NN cord-337137-0ey40gzw 45 38 - - HYPH cord-337137-0ey40gzw 45 39 lucent lucent NN cord-337137-0ey40gzw 45 40 centre centre NN cord-337137-0ey40gzw 45 41 . . . cord-337137-0ey40gzw 46 1 Scale scale NN cord-337137-0ey40gzw 46 2 bars bar NNS cord-337137-0ey40gzw 46 3 = = SYM cord-337137-0ey40gzw 46 4 200 200 CD cord-337137-0ey40gzw 46 5 nm nm NN cord-337137-0ey40gzw 46 6 ( ( -LRB- cord-337137-0ey40gzw 46 7 A a NN cord-337137-0ey40gzw 46 8 ) ) -RRB- cord-337137-0ey40gzw 46 9 and and CC cord-337137-0ey40gzw 47 1 50 50 CD cord-337137-0ey40gzw 47 2 nm nm NN cord-337137-0ey40gzw 47 3 ( ( -LRB- cord-337137-0ey40gzw 47 4 B b NN cord-337137-0ey40gzw 47 5 ) ) -RRB- cord-337137-0ey40gzw 47 6 Diffuse diffuse VB cord-337137-0ey40gzw 47 7 alveolar alveolar JJ cord-337137-0ey40gzw 47 8 damage damage NN cord-337137-0ey40gzw 47 9 is be VBZ cord-337137-0ey40gzw 47 10 the the DT cord-337137-0ey40gzw 47 11 most most RBS cord-337137-0ey40gzw 47 12 characteristic characteristic JJ cord-337137-0ey40gzw 47 13 pathology pathology NN cord-337137-0ey40gzw 47 14 in in IN cord-337137-0ey40gzw 47 15 SARS SARS NNP cord-337137-0ey40gzw 48 1 Most Most JJS cord-337137-0ey40gzw 48 2 data datum NNS cord-337137-0ey40gzw 48 3 on on IN cord-337137-0ey40gzw 48 4 the the DT cord-337137-0ey40gzw 48 5 human human JJ cord-337137-0ey40gzw 48 6 pathology pathology NN cord-337137-0ey40gzw 48 7 of of IN cord-337137-0ey40gzw 48 8 SARS SARS NNP cord-337137-0ey40gzw 48 9 come come VBP cord-337137-0ey40gzw 48 10 from from IN cord-337137-0ey40gzw 48 11 autopsy autopsy JJ cord-337137-0ey40gzw 48 12 studies study NNS cord-337137-0ey40gzw 48 13 of of IN cord-337137-0ey40gzw 48 14 fatal fatal JJ cord-337137-0ey40gzw 48 15 cases case NNS cord-337137-0ey40gzw 48 16 [ [ -LRB- cord-337137-0ey40gzw 48 17 14 14 CD cord-337137-0ey40gzw 48 18 ] ] -RRB- cord-337137-0ey40gzw 48 19 [ [ -LRB- cord-337137-0ey40gzw 48 20 15 15 CD cord-337137-0ey40gzw 48 21 ] ] -RRB- cord-337137-0ey40gzw 49 1 [ [ -LRB- cord-337137-0ey40gzw 49 2 16 16 CD cord-337137-0ey40gzw 49 3 ] ] -RRB- cord-337137-0ey40gzw 49 4 [ [ -LRB- cord-337137-0ey40gzw 49 5 17 17 CD cord-337137-0ey40gzw 49 6 ] ] -RRB- cord-337137-0ey40gzw 50 1 [ [ -LRB- cord-337137-0ey40gzw 50 2 18 18 CD cord-337137-0ey40gzw 50 3 ] ] -RRB- cord-337137-0ey40gzw 50 4 [ [ -LRB- cord-337137-0ey40gzw 50 5 19 19 CD cord-337137-0ey40gzw 50 6 ] ] -RRB- cord-337137-0ey40gzw 50 7 [ [ -LRB- cord-337137-0ey40gzw 50 8 20 20 CD cord-337137-0ey40gzw 50 9 ] ] -RRB- cord-337137-0ey40gzw 50 10 [ [ -LRB- cord-337137-0ey40gzw 50 11 21 21 CD cord-337137-0ey40gzw 50 12 ] ] -RRB- cord-337137-0ey40gzw 50 13 . . . cord-337137-0ey40gzw 51 1 These these DT cord-337137-0ey40gzw 51 2 reports report NNS cord-337137-0ey40gzw 51 3 thus thus RB cord-337137-0ey40gzw 51 4 reflect reflect VBP cord-337137-0ey40gzw 51 5 the the DT cord-337137-0ey40gzw 51 6 terminal terminal JJ cord-337137-0ey40gzw 51 7 stages stage NNS cord-337137-0ey40gzw 51 8 and and CC cord-337137-0ey40gzw 51 9 are be VBP cord-337137-0ey40gzw 51 10 likely likely JJ cord-337137-0ey40gzw 51 11 to to TO cord-337137-0ey40gzw 51 12 represent represent VB cord-337137-0ey40gzw 51 13 only only RB cord-337137-0ey40gzw 51 14 the the DT cord-337137-0ey40gzw 51 15 more more RBR cord-337137-0ey40gzw 51 16 severe severe JJ cord-337137-0ey40gzw 51 17 end end NN cord-337137-0ey40gzw 51 18 of of IN cord-337137-0ey40gzw 51 19 the the DT cord-337137-0ey40gzw 51 20 spectrum spectrum NN cord-337137-0ey40gzw 51 21 of of IN cord-337137-0ey40gzw 51 22 SARS SARS NNP cord-337137-0ey40gzw 51 23 . . . cord-337137-0ey40gzw 52 1 Treatment treatment NN cord-337137-0ey40gzw 52 2 and and CC cord-337137-0ey40gzw 52 3 co co JJ cord-337137-0ey40gzw 52 4 - - JJ cord-337137-0ey40gzw 52 5 morbid morbid JJ cord-337137-0ey40gzw 52 6 conditions condition NNS cord-337137-0ey40gzw 52 7 might may MD cord-337137-0ey40gzw 52 8 also also RB cord-337137-0ey40gzw 52 9 modify modify VB cord-337137-0ey40gzw 52 10 the the DT cord-337137-0ey40gzw 52 11 pathological pathological JJ cord-337137-0ey40gzw 52 12 changes change NNS cord-337137-0ey40gzw 52 13 . . . cord-337137-0ey40gzw 53 1 Diffuse diffuse JJ cord-337137-0ey40gzw 53 2 alveolar alveolar NN cord-337137-0ey40gzw 53 3 damage damage NN cord-337137-0ey40gzw 53 4 at at IN cord-337137-0ey40gzw 53 5 different different JJ cord-337137-0ey40gzw 53 6 stages stage NNS cord-337137-0ey40gzw 53 7 of of IN cord-337137-0ey40gzw 53 8 organization organization NN cord-337137-0ey40gzw 53 9 is be VBZ cord-337137-0ey40gzw 53 10 the the DT cord-337137-0ey40gzw 53 11 most most RBS cord-337137-0ey40gzw 53 12 consistent consistent JJ cord-337137-0ey40gzw 53 13 finding finding NN cord-337137-0ey40gzw 53 14 in in IN cord-337137-0ey40gzw 53 15 the the DT cord-337137-0ey40gzw 53 16 lungs lung NNS cord-337137-0ey40gzw 53 17 of of IN cord-337137-0ey40gzw 53 18 SARS SARS NNP cord-337137-0ey40gzw 53 19 patients patient NNS cord-337137-0ey40gzw 53 20 in in IN cord-337137-0ey40gzw 53 21 the the DT cord-337137-0ey40gzw 53 22 terminal terminal JJ cord-337137-0ey40gzw 53 23 stage stage NN cord-337137-0ey40gzw 53 24 ( ( -LRB- cord-337137-0ey40gzw 53 25 Figures figure NNS cord-337137-0ey40gzw 53 26 2A-2F 2a-2f CD cord-337137-0ey40gzw 53 27 ) ) -RRB- cord-337137-0ey40gzw 53 28 . . . cord-337137-0ey40gzw 54 1 Multinucleated multinucleated JJ cord-337137-0ey40gzw 54 2 syncytial syncytial JJ cord-337137-0ey40gzw 54 3 cells cell NNS cord-337137-0ey40gzw 54 4 ( ( -LRB- cord-337137-0ey40gzw 54 5 Figures figure NNS cord-337137-0ey40gzw 54 6 2 2 CD cord-337137-0ey40gzw 54 7 G g NN cord-337137-0ey40gzw 54 8 and and CC cord-337137-0ey40gzw 54 9 2H 2h NN cord-337137-0ey40gzw 54 10 ) ) -RRB- cord-337137-0ey40gzw 54 11 are be VBP cord-337137-0ey40gzw 54 12 characteristic characteristic JJ cord-337137-0ey40gzw 54 13 , , , cord-337137-0ey40gzw 54 14 although although IN cord-337137-0ey40gzw 54 15 these these DT cord-337137-0ey40gzw 54 16 cells cell NNS cord-337137-0ey40gzw 54 17 are be VBP cord-337137-0ey40gzw 54 18 rare rare JJ cord-337137-0ey40gzw 54 19 . . . cord-337137-0ey40gzw 55 1 Apart apart RB cord-337137-0ey40gzw 55 2 from from IN cord-337137-0ey40gzw 55 3 when when WRB cord-337137-0ey40gzw 55 4 secondary secondary JJ cord-337137-0ey40gzw 55 5 infection infection NN cord-337137-0ey40gzw 55 6 occurs occur VBZ cord-337137-0ey40gzw 55 7 , , , cord-337137-0ey40gzw 55 8 the the DT cord-337137-0ey40gzw 55 9 lack lack NN cord-337137-0ey40gzw 55 10 of of IN cord-337137-0ey40gzw 55 11 a a DT cord-337137-0ey40gzw 55 12 prominent prominent JJ cord-337137-0ey40gzw 55 13 inflammatory inflammatory JJ cord-337137-0ey40gzw 55 14 response response NN cord-337137-0ey40gzw 55 15 is be VBZ cord-337137-0ey40gzw 55 16 also also RB cord-337137-0ey40gzw 55 17 distinctive distinctive JJ cord-337137-0ey40gzw 55 18 . . . cord-337137-0ey40gzw 56 1 SARS SARS NNP cord-337137-0ey40gzw 56 2 - - HYPH cord-337137-0ey40gzw 56 3 CoV CoV NNP cord-337137-0ey40gzw 56 4 is be VBZ cord-337137-0ey40gzw 56 5 explicitly explicitly RB cord-337137-0ey40gzw 56 6 detected detect VBN cord-337137-0ey40gzw 56 7 in in IN cord-337137-0ey40gzw 56 8 the the DT cord-337137-0ey40gzw 56 9 alveolar alveolar JJ cord-337137-0ey40gzw 56 10 lining lining NN cord-337137-0ey40gzw 56 11 cells cell NNS cord-337137-0ey40gzw 56 12 ( ( -LRB- cord-337137-0ey40gzw 56 13 Figures figure NNS cord-337137-0ey40gzw 56 14 2I 2i NN cord-337137-0ey40gzw 56 15 and and CC cord-337137-0ey40gzw 56 16 2J 2j CD cord-337137-0ey40gzw 56 17 ) ) -RRB- cord-337137-0ey40gzw 56 18 [ [ -LRB- cord-337137-0ey40gzw 56 19 10 10 CD cord-337137-0ey40gzw 56 20 , , , cord-337137-0ey40gzw 56 21 [ [ -LRB- cord-337137-0ey40gzw 56 22 22 22 CD cord-337137-0ey40gzw 56 23 ] ] -RRB- cord-337137-0ey40gzw 56 24 [ [ -LRB- cord-337137-0ey40gzw 56 25 23 23 CD cord-337137-0ey40gzw 56 26 ] ] -RRB- cord-337137-0ey40gzw 57 1 [ [ -LRB- cord-337137-0ey40gzw 57 2 24 24 CD cord-337137-0ey40gzw 57 3 ] ] -RRB- cord-337137-0ey40gzw 57 4 [ [ -LRB- cord-337137-0ey40gzw 57 5 25 25 CD cord-337137-0ey40gzw 57 6 ] ] -RRB- cord-337137-0ey40gzw 57 7 [ [ -LRB- cord-337137-0ey40gzw 57 8 26 26 CD cord-337137-0ey40gzw 57 9 ] ] -RRB- cord-337137-0ey40gzw 57 10 [ [ -LRB- cord-337137-0ey40gzw 57 11 27 27 CD cord-337137-0ey40gzw 57 12 ] ] -RRB- cord-337137-0ey40gzw 57 13 . . . cord-337137-0ey40gzw 58 1 No no DT cord-337137-0ey40gzw 58 2 specific specific JJ cord-337137-0ey40gzw 58 3 pathology pathology NN cord-337137-0ey40gzw 58 4 is be VBZ cord-337137-0ey40gzw 58 5 identified identify VBN cord-337137-0ey40gzw 58 6 in in IN cord-337137-0ey40gzw 58 7 the the DT cord-337137-0ey40gzw 58 8 gastrointestinal gastrointestinal JJ cord-337137-0ey40gzw 58 9 tract tract NN cord-337137-0ey40gzw 58 10 ( ( -LRB- cord-337137-0ey40gzw 58 11 Figure figure NN cord-337137-0ey40gzw 58 12 3 3 CD cord-337137-0ey40gzw 58 13 ) ) -RRB- cord-337137-0ey40gzw 58 14 [ [ -LRB- cord-337137-0ey40gzw 58 15 5 5 CD cord-337137-0ey40gzw 58 16 ] ] -RRB- cord-337137-0ey40gzw 58 17 , , , cord-337137-0ey40gzw 58 18 urinary urinary JJ cord-337137-0ey40gzw 58 19 system system NN cord-337137-0ey40gzw 58 20 [ [ -LRB- cord-337137-0ey40gzw 58 21 8 8 CD cord-337137-0ey40gzw 58 22 ] ] -RRB- cord-337137-0ey40gzw 58 23 , , , cord-337137-0ey40gzw 58 24 or or CC cord-337137-0ey40gzw 58 25 other other JJ cord-337137-0ey40gzw 58 26 organ organ NN cord-337137-0ey40gzw 58 27 systems system NNS cord-337137-0ey40gzw 58 28 [ [ -LRB- cord-337137-0ey40gzw 58 29 28 28 CD cord-337137-0ey40gzw 58 30 ] ] -RRB- cord-337137-0ey40gzw 58 31 , , , cord-337137-0ey40gzw 58 32 apart apart RB cord-337137-0ey40gzw 58 33 from from IN cord-337137-0ey40gzw 58 34 that that DT cord-337137-0ey40gzw 58 35 related relate VBN cord-337137-0ey40gzw 58 36 to to IN cord-337137-0ey40gzw 58 37 end end NN cord-337137-0ey40gzw 58 38 - - HYPH cord-337137-0ey40gzw 58 39 stage stage NN cord-337137-0ey40gzw 58 40 multi multi JJ cord-337137-0ey40gzw 58 41 - - JJ cord-337137-0ey40gzw 58 42 organ organ JJ cord-337137-0ey40gzw 58 43 failure failure NN cord-337137-0ey40gzw 58 44 or or CC cord-337137-0ey40gzw 58 45 those those DT cord-337137-0ey40gzw 58 46 changes change NNS cord-337137-0ey40gzw 58 47 secondary secondary JJ cord-337137-0ey40gzw 58 48 to to IN cord-337137-0ey40gzw 58 49 treatment treatment NN cord-337137-0ey40gzw 58 50 . . . cord-337137-0ey40gzw 59 1 It -PRON- PRP cord-337137-0ey40gzw 59 2 is be VBZ cord-337137-0ey40gzw 59 3 important important JJ cord-337137-0ey40gzw 59 4 to to TO cord-337137-0ey40gzw 59 5 note note VB cord-337137-0ey40gzw 59 6 that that IN cord-337137-0ey40gzw 59 7 in in IN cord-337137-0ey40gzw 59 8 some some DT cord-337137-0ey40gzw 59 9 organs organ NNS cord-337137-0ey40gzw 59 10 such such JJ cord-337137-0ey40gzw 59 11 as as IN cord-337137-0ey40gzw 59 12 the the DT cord-337137-0ey40gzw 59 13 liver liver NN cord-337137-0ey40gzw 59 14 , , , cord-337137-0ey40gzw 59 15 while while IN cord-337137-0ey40gzw 59 16 definitive definitive JJ cord-337137-0ey40gzw 59 17 and and CC cord-337137-0ey40gzw 59 18 distinct distinct JJ cord-337137-0ey40gzw 59 19 morphological morphological JJ cord-337137-0ey40gzw 59 20 and and CC cord-337137-0ey40gzw 59 21 functional functional JJ cord-337137-0ey40gzw 59 22 changes change NNS cord-337137-0ey40gzw 59 23 are be VBP cord-337137-0ey40gzw 59 24 observed observe VBN cord-337137-0ey40gzw 59 25 , , , cord-337137-0ey40gzw 59 26 SARS SARS NNP cord-337137-0ey40gzw 59 27 - - HYPH cord-337137-0ey40gzw 59 28 CoV CoV NNP cord-337137-0ey40gzw 59 29 may may MD cord-337137-0ey40gzw 59 30 not not RB cord-337137-0ey40gzw 59 31 be be VB cord-337137-0ey40gzw 59 32 unequivocally unequivocally RB cord-337137-0ey40gzw 59 33 demonstrable demonstrable JJ cord-337137-0ey40gzw 59 34 [ [ -LRB- cord-337137-0ey40gzw 59 35 29 29 CD cord-337137-0ey40gzw 59 36 ] ] -RRB- cord-337137-0ey40gzw 59 37 . . . cord-337137-0ey40gzw 60 1 It -PRON- PRP cord-337137-0ey40gzw 60 2 is be VBZ cord-337137-0ey40gzw 60 3 clear clear JJ cord-337137-0ey40gzw 60 4 that that IN cord-337137-0ey40gzw 60 5 our -PRON- PRP$ cord-337137-0ey40gzw 60 6 understanding understanding NN cord-337137-0ey40gzw 60 7 of of IN cord-337137-0ey40gzw 60 8 the the DT cord-337137-0ey40gzw 60 9 pathology pathology NN cord-337137-0ey40gzw 60 10 of of IN cord-337137-0ey40gzw 60 11 SARS SARS NNP cord-337137-0ey40gzw 60 12 is be VBZ cord-337137-0ey40gzw 60 13 incomplete incomplete JJ cord-337137-0ey40gzw 60 14 . . . cord-337137-0ey40gzw 61 1 An an DT cord-337137-0ey40gzw 61 2 obvious obvious JJ cord-337137-0ey40gzw 61 3 large large JJ cord-337137-0ey40gzw 61 4 gap gap NN cord-337137-0ey40gzw 61 5 is be VBZ cord-337137-0ey40gzw 61 6 the the DT cord-337137-0ey40gzw 61 7 lack lack NN cord-337137-0ey40gzw 61 8 of of IN cord-337137-0ey40gzw 61 9 information information NN cord-337137-0ey40gzw 61 10 on on IN cord-337137-0ey40gzw 61 11 the the DT cord-337137-0ey40gzw 61 12 early early JJ cord-337137-0ey40gzw 61 13 pathological pathological JJ cord-337137-0ey40gzw 61 14 changes change NNS cord-337137-0ey40gzw 61 15 of of IN cord-337137-0ey40gzw 61 16 SARS SARS NNP cord-337137-0ey40gzw 61 17 . . . cord-337137-0ey40gzw 62 1 During during IN cord-337137-0ey40gzw 62 2 the the DT cord-337137-0ey40gzw 62 3 epidemic epidemic NN cord-337137-0ey40gzw 62 4 , , , cord-337137-0ey40gzw 62 5 very very RB cord-337137-0ey40gzw 62 6 few few JJ cord-337137-0ey40gzw 62 7 biopsies biopsy NNS cord-337137-0ey40gzw 62 8 were be VBD cord-337137-0ey40gzw 62 9 obtained obtain VBN cord-337137-0ey40gzw 62 10 from from IN cord-337137-0ey40gzw 62 11 patients patient NNS cord-337137-0ey40gzw 62 12 with with IN cord-337137-0ey40gzw 62 13 clinically clinically RB cord-337137-0ey40gzw 62 14 active active JJ cord-337137-0ey40gzw 62 15 SARS SARS NNP cord-337137-0ey40gzw 62 16 . . . cord-337137-0ey40gzw 63 1 The the DT cord-337137-0ey40gzw 63 2 study study NN cord-337137-0ey40gzw 63 3 of of IN cord-337137-0ey40gzw 63 4 animal animal NN cord-337137-0ey40gzw 63 5 models model NNS cord-337137-0ey40gzw 63 6 is be VBZ cord-337137-0ey40gzw 63 7 important important JJ cord-337137-0ey40gzw 63 8 in in IN cord-337137-0ey40gzw 63 9 a a DT cord-337137-0ey40gzw 63 10 number number NN cord-337137-0ey40gzw 63 11 of of IN cord-337137-0ey40gzw 63 12 ways way NNS cord-337137-0ey40gzw 63 13 . . . cord-337137-0ey40gzw 64 1 It -PRON- PRP cord-337137-0ey40gzw 64 2 has have VBZ cord-337137-0ey40gzw 64 3 allowed allow VBN cord-337137-0ey40gzw 64 4 the the DT cord-337137-0ey40gzw 64 5 establishment establishment NN cord-337137-0ey40gzw 64 6 of of IN cord-337137-0ey40gzw 64 7 SARS SARS NNP cord-337137-0ey40gzw 64 8 - - HYPH cord-337137-0ey40gzw 64 9 CoV CoV NNP cord-337137-0ey40gzw 64 10 as as IN cord-337137-0ey40gzw 64 11 the the DT cord-337137-0ey40gzw 64 12 aetiological aetiological JJ cord-337137-0ey40gzw 64 13 agent agent NN cord-337137-0ey40gzw 64 14 [ [ -LRB- cord-337137-0ey40gzw 64 15 30 30 CD cord-337137-0ey40gzw 64 16 ] ] -RRB- cord-337137-0ey40gzw 64 17 . . . cord-337137-0ey40gzw 65 1 It -PRON- PRP cord-337137-0ey40gzw 65 2 also also RB cord-337137-0ey40gzw 65 3 provides provide VBZ cord-337137-0ey40gzw 65 4 controlled control VBN cord-337137-0ey40gzw 65 5 conditions condition NNS cord-337137-0ey40gzw 65 6 for for IN cord-337137-0ey40gzw 65 7 the the DT cord-337137-0ey40gzw 65 8 study study NN cord-337137-0ey40gzw 65 9 of of IN cord-337137-0ey40gzw 65 10 early early JJ cord-337137-0ey40gzw 65 11 changes change NNS cord-337137-0ey40gzw 65 12 in in IN cord-337137-0ey40gzw 65 13 the the DT cord-337137-0ey40gzw 65 14 disease disease NN cord-337137-0ey40gzw 65 15 . . . cord-337137-0ey40gzw 66 1 Initial initial JJ cord-337137-0ey40gzw 66 2 studies study NNS cord-337137-0ey40gzw 66 3 of of IN cord-337137-0ey40gzw 66 4 macaque macaque NN cord-337137-0ey40gzw 66 5 models model NNS cord-337137-0ey40gzw 66 6 were be VBD cord-337137-0ey40gzw 66 7 promising promising JJ cord-337137-0ey40gzw 66 8 . . . cord-337137-0ey40gzw 67 1 The the DT cord-337137-0ey40gzw 67 2 histology histology NN cord-337137-0ey40gzw 67 3 of of IN cord-337137-0ey40gzw 67 4 infected infected JJ cord-337137-0ey40gzw 67 5 lung lung NN cord-337137-0ey40gzw 67 6 tissue tissue NN cord-337137-0ey40gzw 67 7 is be VBZ cord-337137-0ey40gzw 67 8 similar similar JJ cord-337137-0ey40gzw 67 9 to to IN cord-337137-0ey40gzw 67 10 that that DT cord-337137-0ey40gzw 67 11 in in IN cord-337137-0ey40gzw 67 12 humans human NNS cord-337137-0ey40gzw 67 13 [ [ -LRB- cord-337137-0ey40gzw 67 14 31 31 CD cord-337137-0ey40gzw 67 15 ] ] -RRB- cord-337137-0ey40gzw 67 16 [ [ -LRB- cord-337137-0ey40gzw 67 17 32 32 CD cord-337137-0ey40gzw 67 18 ] ] -RRB- cord-337137-0ey40gzw 67 19 [ [ -LRB- cord-337137-0ey40gzw 67 20 33 33 CD cord-337137-0ey40gzw 67 21 ] ] -RRB- cord-337137-0ey40gzw 67 22 . . . cord-337137-0ey40gzw 68 1 Both both DT cord-337137-0ey40gzw 68 2 acute acute JJ cord-337137-0ey40gzw 68 3 and and CC cord-337137-0ey40gzw 68 4 organized organized JJ cord-337137-0ey40gzw 68 5 stages stage NNS cord-337137-0ey40gzw 68 6 of of IN cord-337137-0ey40gzw 68 7 diffuse diffuse JJ cord-337137-0ey40gzw 68 8 alveolar alveolar JJ cord-337137-0ey40gzw 68 9 damage damage NN cord-337137-0ey40gzw 68 10 were be VBD cord-337137-0ey40gzw 68 11 seen see VBN cord-337137-0ey40gzw 68 12 when when WRB cord-337137-0ey40gzw 68 13 the the DT cord-337137-0ey40gzw 68 14 macaques macaque NNS cord-337137-0ey40gzw 68 15 were be VBD cord-337137-0ey40gzw 68 16 sacrificed sacrifice VBN cord-337137-0ey40gzw 68 17 on on IN cord-337137-0ey40gzw 68 18 the the DT cord-337137-0ey40gzw 68 19 sixth sixth JJ cord-337137-0ey40gzw 68 20 day day NN cord-337137-0ey40gzw 68 21 after after IN cord-337137-0ey40gzw 68 22 a a DT cord-337137-0ey40gzw 68 23 heavy heavy JJ cord-337137-0ey40gzw 68 24 dose dose NN cord-337137-0ey40gzw 68 25 of of IN cord-337137-0ey40gzw 68 26 the the DT cord-337137-0ey40gzw 68 27 virus virus NN cord-337137-0ey40gzw 68 28 . . . cord-337137-0ey40gzw 69 1 SARS SARS NNP cord-337137-0ey40gzw 69 2 - - HYPH cord-337137-0ey40gzw 69 3 CoV CoV NNP cord-337137-0ey40gzw 69 4 was be VBD cord-337137-0ey40gzw 69 5 detected detect VBN cord-337137-0ey40gzw 69 6 in in IN cord-337137-0ey40gzw 69 7 the the DT cord-337137-0ey40gzw 69 8 alveolar alveolar JJ cord-337137-0ey40gzw 69 9 epithelial epithelial JJ cord-337137-0ey40gzw 69 10 cells cell NNS cord-337137-0ey40gzw 69 11 and and CC cord-337137-0ey40gzw 69 12 in in IN cord-337137-0ey40gzw 69 13 the the DT cord-337137-0ey40gzw 69 14 intra intra JJ cord-337137-0ey40gzw 69 15 - - JJ cord-337137-0ey40gzw 69 16 alveolar alveolar JJ cord-337137-0ey40gzw 69 17 syncytial syncytial JJ cord-337137-0ey40gzw 69 18 cells cell NNS cord-337137-0ey40gzw 69 19 . . . cord-337137-0ey40gzw 70 1 However however RB cord-337137-0ey40gzw 70 2 , , , cord-337137-0ey40gzw 70 3 detailed detailed JJ cord-337137-0ey40gzw 70 4 morphological morphological JJ cord-337137-0ey40gzw 70 5 studies study NNS cord-337137-0ey40gzw 70 6 and and CC cord-337137-0ey40gzw 70 7 viral viral JJ cord-337137-0ey40gzw 70 8 distribution distribution NN cord-337137-0ey40gzw 70 9 in in IN cord-337137-0ey40gzw 70 10 other other JJ cord-337137-0ey40gzw 70 11 organs organ NNS cord-337137-0ey40gzw 70 12 in in IN cord-337137-0ey40gzw 70 13 these these DT cord-337137-0ey40gzw 70 14 animal animal NN cord-337137-0ey40gzw 70 15 studies study NNS cord-337137-0ey40gzw 70 16 are be VBP cord-337137-0ey40gzw 70 17 lacking lack VBG cord-337137-0ey40gzw 70 18 . . . cord-337137-0ey40gzw 71 1 In in IN cord-337137-0ey40gzw 71 2 studies study NNS cord-337137-0ey40gzw 71 3 involving involve VBG cord-337137-0ey40gzw 71 4 longer long JJR cord-337137-0ey40gzw 71 5 observation observation NN cord-337137-0ey40gzw 71 6 times time NNS cord-337137-0ey40gzw 71 7 , , , cord-337137-0ey40gzw 71 8 the the DT cord-337137-0ey40gzw 71 9 disease disease NN cord-337137-0ey40gzw 71 10 in in IN cord-337137-0ey40gzw 71 11 macaque macaque NN cord-337137-0ey40gzw 71 12 models model NNS cord-337137-0ey40gzw 71 13 appears appear VBZ cord-337137-0ey40gzw 71 14 self self NN cord-337137-0ey40gzw 71 15 - - HYPH cord-337137-0ey40gzw 71 16 limiting limit VBG cord-337137-0ey40gzw 71 17 and and CC cord-337137-0ey40gzw 71 18 different different JJ cord-337137-0ey40gzw 71 19 from from IN cord-337137-0ey40gzw 71 20 the the DT cord-337137-0ey40gzw 71 21 genuine genuine JJ cord-337137-0ey40gzw 71 22 human human JJ cord-337137-0ey40gzw 71 23 disease disease NN cord-337137-0ey40gzw 71 24 . . . cord-337137-0ey40gzw 72 1 The the DT cord-337137-0ey40gzw 72 2 usefulness usefulness NN cord-337137-0ey40gzw 72 3 of of IN cord-337137-0ey40gzw 72 4 the the DT cord-337137-0ey40gzw 72 5 macaque macaque NN cord-337137-0ey40gzw 72 6 as as IN cord-337137-0ey40gzw 72 7 a a DT cord-337137-0ey40gzw 72 8 model model NN cord-337137-0ey40gzw 72 9 of of IN cord-337137-0ey40gzw 72 10 the the DT cord-337137-0ey40gzw 72 11 disease disease NN cord-337137-0ey40gzw 72 12 remains remain VBZ cord-337137-0ey40gzw 72 13 to to TO cord-337137-0ey40gzw 72 14 be be VB cord-337137-0ey40gzw 72 15 established establish VBN cord-337137-0ey40gzw 72 16 [ [ -LRB- cord-337137-0ey40gzw 72 17 32 32 CD cord-337137-0ey40gzw 72 18 , , , cord-337137-0ey40gzw 72 19 33 33 CD cord-337137-0ey40gzw 72 20 ] ] -RRB- cord-337137-0ey40gzw 72 21 . . . cord-337137-0ey40gzw 73 1 Civet civet NN cord-337137-0ey40gzw 73 2 cats cat NNS cord-337137-0ey40gzw 73 3 , , , cord-337137-0ey40gzw 73 4 domestic domestic JJ cord-337137-0ey40gzw 73 5 cats cat NNS cord-337137-0ey40gzw 73 6 , , , cord-337137-0ey40gzw 73 7 and and CC cord-337137-0ey40gzw 73 8 ferrets ferret NNS cord-337137-0ey40gzw 73 9 are be VBP cord-337137-0ey40gzw 73 10 thought think VBN cord-337137-0ey40gzw 73 11 to to TO cord-337137-0ey40gzw 73 12 have have VB cord-337137-0ey40gzw 73 13 been be VBN cord-337137-0ey40gzw 73 14 potential potential JJ cord-337137-0ey40gzw 73 15 reservoirs reservoir NNS cord-337137-0ey40gzw 73 16 of of IN cord-337137-0ey40gzw 73 17 the the DT cord-337137-0ey40gzw 73 18 virus virus NN cord-337137-0ey40gzw 73 19 during during IN cord-337137-0ey40gzw 73 20 the the DT cord-337137-0ey40gzw 73 21 epidemics epidemic NNS cord-337137-0ey40gzw 73 22 and and CC cord-337137-0ey40gzw 73 23 subsequent subsequent JJ cord-337137-0ey40gzw 73 24 smaller small JJR cord-337137-0ey40gzw 73 25 outbreaks outbreak NNS cord-337137-0ey40gzw 73 26 in in IN cord-337137-0ey40gzw 73 27 mainland mainland NN cord-337137-0ey40gzw 73 28 China China NNP cord-337137-0ey40gzw 73 29 [ [ -LRB- cord-337137-0ey40gzw 73 30 34 34 CD cord-337137-0ey40gzw 73 31 ] ] -RRB- cord-337137-0ey40gzw 73 32 . . . cord-337137-0ey40gzw 74 1 The the DT cord-337137-0ey40gzw 74 2 animal animal NN cord-337137-0ey40gzw 74 3 coronavirus coronavirus NN cord-337137-0ey40gzw 74 4 identified identify VBN cord-337137-0ey40gzw 74 5 in in IN cord-337137-0ey40gzw 74 6 civet civet NN cord-337137-0ey40gzw 74 7 cats cat NNS cord-337137-0ey40gzw 74 8 shows show VBZ cord-337137-0ey40gzw 74 9 high high JJ cord-337137-0ey40gzw 74 10 sequence sequence NN cord-337137-0ey40gzw 74 11 identity identity NN cord-337137-0ey40gzw 74 12 with with IN cord-337137-0ey40gzw 74 13 , , , cord-337137-0ey40gzw 74 14 but but CC cord-337137-0ey40gzw 74 15 is be VBZ cord-337137-0ey40gzw 74 16 distinct distinct JJ cord-337137-0ey40gzw 74 17 from from IN cord-337137-0ey40gzw 74 18 , , , cord-337137-0ey40gzw 74 19 SARS SARS NNP cord-337137-0ey40gzw 74 20 - - HYPH cord-337137-0ey40gzw 74 21 CoV CoV NNP cord-337137-0ey40gzw 74 22 [ [ -LRB- cord-337137-0ey40gzw 74 23 2 2 CD cord-337137-0ey40gzw 74 24 , , , cord-337137-0ey40gzw 74 25 35 35 CD cord-337137-0ey40gzw 74 26 ] ] -RRB- cord-337137-0ey40gzw 74 27 . . . cord-337137-0ey40gzw 75 1 Recent recent JJ cord-337137-0ey40gzw 75 2 evidence evidence NN cord-337137-0ey40gzw 75 3 also also RB cord-337137-0ey40gzw 75 4 suggests suggest VBZ cord-337137-0ey40gzw 75 5 that that IN cord-337137-0ey40gzw 75 6 wide wide JJ cord-337137-0ey40gzw 75 7 Chinese chinese JJ cord-337137-0ey40gzw 75 8 horseshoe horseshoe NN cord-337137-0ey40gzw 75 9 bats bat NNS cord-337137-0ey40gzw 75 10 harbour harbour VBP cord-337137-0ey40gzw 75 11 a a DT cord-337137-0ey40gzw 75 12 closely closely RB cord-337137-0ey40gzw 75 13 related related JJ cord-337137-0ey40gzw 75 14 bat bat NN cord-337137-0ey40gzw 75 15 - - HYPH cord-337137-0ey40gzw 75 16 SARS SARS NNP cord-337137-0ey40gzw 75 17 - - HYPH cord-337137-0ey40gzw 75 18 CoV CoV NNP cord-337137-0ey40gzw 75 19 which which WDT cord-337137-0ey40gzw 75 20 might may MD cord-337137-0ey40gzw 75 21 also also RB cord-337137-0ey40gzw 75 22 act act VB cord-337137-0ey40gzw 75 23 as as IN cord-337137-0ey40gzw 75 24 the the DT cord-337137-0ey40gzw 75 25 animal animal NN cord-337137-0ey40gzw 75 26 reservoir reservoir NN cord-337137-0ey40gzw 75 27 [ [ -LRB- cord-337137-0ey40gzw 75 28 36 36 CD cord-337137-0ey40gzw 75 29 ] ] -RRB- cord-337137-0ey40gzw 75 30 . . . cord-337137-0ey40gzw 76 1 Again again RB cord-337137-0ey40gzw 76 2 , , , cord-337137-0ey40gzw 76 3 details detail NNS cord-337137-0ey40gzw 76 4 concerning concern VBG cord-337137-0ey40gzw 76 5 the the DT cord-337137-0ey40gzw 76 6 distribution distribution NN cord-337137-0ey40gzw 76 7 of of IN cord-337137-0ey40gzw 76 8 virus virus NN cord-337137-0ey40gzw 76 9 in in IN cord-337137-0ey40gzw 76 10 different different JJ cord-337137-0ey40gzw 76 11 organs organ NNS cord-337137-0ey40gzw 76 12 in in IN cord-337137-0ey40gzw 76 13 these these DT cord-337137-0ey40gzw 76 14 animals animal NNS cord-337137-0ey40gzw 76 15 and and CC cord-337137-0ey40gzw 76 16 the the DT cord-337137-0ey40gzw 76 17 information information NN cord-337137-0ey40gzw 76 18 on on IN cord-337137-0ey40gzw 76 19 the the DT cord-337137-0ey40gzw 76 20 pathology pathology NN cord-337137-0ey40gzw 76 21 in in IN cord-337137-0ey40gzw 76 22 the the DT cord-337137-0ey40gzw 76 23 diseased diseased JJ cord-337137-0ey40gzw 76 24 or or CC cord-337137-0ey40gzw 76 25 carrier carrier NN cord-337137-0ey40gzw 76 26 animals animal NNS cord-337137-0ey40gzw 76 27 are be VBP cord-337137-0ey40gzw 76 28 , , , cord-337137-0ey40gzw 76 29 surprisingly surprisingly RB cord-337137-0ey40gzw 76 30 , , , cord-337137-0ey40gzw 76 31 sparse sparse JJ cord-337137-0ey40gzw 76 32 [ [ -LRB- cord-337137-0ey40gzw 76 33 32 32 CD cord-337137-0ey40gzw 76 34 , , , cord-337137-0ey40gzw 76 35 35 35 CD cord-337137-0ey40gzw 76 36 ] ] -RRB- cord-337137-0ey40gzw 76 37 . . . cord-337137-0ey40gzw 77 1 Other other JJ cord-337137-0ey40gzw 77 2 common common JJ cord-337137-0ey40gzw 77 3 small small JJ cord-337137-0ey40gzw 77 4 laboratory laboratory NN cord-337137-0ey40gzw 77 5 animal animal NN cord-337137-0ey40gzw 77 6 models model NNS cord-337137-0ey40gzw 77 7 , , , cord-337137-0ey40gzw 77 8 such such JJ cord-337137-0ey40gzw 77 9 as as IN cord-337137-0ey40gzw 77 10 the the DT cord-337137-0ey40gzw 77 11 mouse mouse NN cord-337137-0ey40gzw 77 12 , , , cord-337137-0ey40gzw 77 13 are be VBP cord-337137-0ey40gzw 77 14 not not RB cord-337137-0ey40gzw 77 15 particularly particularly RB cord-337137-0ey40gzw 77 16 useful useful JJ cord-337137-0ey40gzw 77 17 . . . cord-337137-0ey40gzw 78 1 SARS SARS NNP cord-337137-0ey40gzw 78 2 - - HYPH cord-337137-0ey40gzw 78 3 CoV CoV NNP cord-337137-0ey40gzw 78 4 has have VBZ cord-337137-0ey40gzw 78 5 a a DT cord-337137-0ey40gzw 78 6 low low JJ cord-337137-0ey40gzw 78 7 virulence virulence NN cord-337137-0ey40gzw 78 8 in in IN cord-337137-0ey40gzw 78 9 ordinary ordinary JJ cord-337137-0ey40gzw 78 10 laboratory laboratory NN cord-337137-0ey40gzw 78 11 mice mouse NNS cord-337137-0ey40gzw 78 12 and and CC cord-337137-0ey40gzw 78 13 very very RB cord-337137-0ey40gzw 78 14 high high JJ cord-337137-0ey40gzw 78 15 levels level NNS cord-337137-0ey40gzw 78 16 of of IN cord-337137-0ey40gzw 78 17 inoculation inoculation NN cord-337137-0ey40gzw 78 18 are be VBP cord-337137-0ey40gzw 78 19 required require VBN cord-337137-0ey40gzw 78 20 to to TO cord-337137-0ey40gzw 78 21 produce produce VB cord-337137-0ey40gzw 78 22 self self NN cord-337137-0ey40gzw 78 23 - - HYPH cord-337137-0ey40gzw 78 24 limiting limit VBG cord-337137-0ey40gzw 78 25 diseases disease NNS cord-337137-0ey40gzw 78 26 . . . cord-337137-0ey40gzw 79 1 These these DT cord-337137-0ey40gzw 79 2 features feature NNS cord-337137-0ey40gzw 79 3 may may MD cord-337137-0ey40gzw 79 4 be be VB cord-337137-0ey40gzw 79 5 Although although IN cord-337137-0ey40gzw 79 6 the the DT cord-337137-0ey40gzw 79 7 latter latter JJ cord-337137-0ey40gzw 79 8 finding finding NN cord-337137-0ey40gzw 79 9 may may MD cord-337137-0ey40gzw 79 10 be be VB cord-337137-0ey40gzw 79 11 related relate VBN cord-337137-0ey40gzw 79 12 to to IN cord-337137-0ey40gzw 79 13 pre pre JJ cord-337137-0ey40gzw 79 14 - - JJ cord-337137-0ey40gzw 79 15 morbid morbid JJ cord-337137-0ey40gzw 79 16 lung lung NN cord-337137-0ey40gzw 79 17 pathology pathology NN cord-337137-0ey40gzw 79 18 , , . cord-337137-0ey40gzw 80 1 a a DT cord-337137-0ey40gzw 80 2 correlation correlation NN cord-337137-0ey40gzw 80 3 with with IN cord-337137-0ey40gzw 80 4 interstitial interstitial JJ cord-337137-0ey40gzw 80 5 fibrosis fibrosis NN cord-337137-0ey40gzw 80 6 and and CC cord-337137-0ey40gzw 80 7 disease disease NN cord-337137-0ey40gzw 80 8 duration duration NN cord-337137-0ey40gzw 80 9 has have VBZ cord-337137-0ey40gzw 80 10 been be VBN cord-337137-0ey40gzw 80 11 demonstrated demonstrate VBN cord-337137-0ey40gzw 80 12 [ [ -LRB- cord-337137-0ey40gzw 80 13 21 21 CD cord-337137-0ey40gzw 80 14 ] ] -RRB- cord-337137-0ey40gzw 80 15 . . . cord-337137-0ey40gzw 81 1 Diffuse diffuse JJ cord-337137-0ey40gzw 81 2 alveolar alveolar NN cord-337137-0ey40gzw 81 3 damage damage NN cord-337137-0ey40gzw 81 4 at at IN cord-337137-0ey40gzw 81 5 different different JJ cord-337137-0ey40gzw 81 6 stages stage NNS cord-337137-0ey40gzw 81 7 of of IN cord-337137-0ey40gzw 81 8 organization organization NN cord-337137-0ey40gzw 81 9 , , , cord-337137-0ey40gzw 81 10 from from IN cord-337137-0ey40gzw 81 11 fibrin fibrin NN cord-337137-0ey40gzw 81 12 deposition deposition NN cord-337137-0ey40gzw 81 13 ( ( -LRB- cord-337137-0ey40gzw 81 14 C C NNP cord-337137-0ey40gzw 81 15 , , , cord-337137-0ey40gzw 81 16 H&E H&E NNP cord-337137-0ey40gzw 81 17 , , , cord-337137-0ey40gzw 81 18 original original JJ cord-337137-0ey40gzw 81 19 magnification magnification NN cord-337137-0ey40gzw 81 20 ×200 ×200 IN cord-337137-0ey40gzw 81 21 ) ) -RRB- cord-337137-0ey40gzw 81 22 , , , cord-337137-0ey40gzw 81 23 to to IN cord-337137-0ey40gzw 81 24 interstitial interstitial JJ cord-337137-0ey40gzw 81 25 fibrosis fibrosis NN cord-337137-0ey40gzw 81 26 ( ( -LRB- cord-337137-0ey40gzw 81 27 D D NNP cord-337137-0ey40gzw 81 28 , , , cord-337137-0ey40gzw 81 29 H&E H&E NNP cord-337137-0ey40gzw 81 30 , , , cord-337137-0ey40gzw 81 31 original original JJ cord-337137-0ey40gzw 81 32 magnification magnification NN cord-337137-0ey40gzw 81 33 ×100 ×100 NFP cord-337137-0ey40gzw 81 34 ) ) -RRB- cord-337137-0ey40gzw 81 35 and and CC cord-337137-0ey40gzw 81 36 cellular cellular JJ cord-337137-0ey40gzw 81 37 organization organization NN cord-337137-0ey40gzw 82 1 ( ( -LRB- cord-337137-0ey40gzw 82 2 E E NNP cord-337137-0ey40gzw 82 3 and and CC cord-337137-0ey40gzw 82 4 F F NNP cord-337137-0ey40gzw 82 5 , , , cord-337137-0ey40gzw 82 6 H&E H&E NNP cord-337137-0ey40gzw 82 7 , , , cord-337137-0ey40gzw 82 8 original original JJ cord-337137-0ey40gzw 82 9 magnification magnification NN cord-337137-0ey40gzw 82 10 ×400 ×400 NN cord-337137-0ey40gzw 82 11 ) ) -RRB- cord-337137-0ey40gzw 82 12 , , , cord-337137-0ey40gzw 82 13 can can MD cord-337137-0ey40gzw 82 14 be be VB cord-337137-0ey40gzw 82 15 detected detect VBN cord-337137-0ey40gzw 82 16 . . . cord-337137-0ey40gzw 83 1 Atypical atypical JJ cord-337137-0ey40gzw 83 2 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 83 3 with with IN cord-337137-0ey40gzw 83 4 enlarged enlarged JJ cord-337137-0ey40gzw 83 5 nuclei nucleus NNS cord-337137-0ey40gzw 83 6 and and CC cord-337137-0ey40gzw 83 7 prominent prominent JJ cord-337137-0ey40gzw 83 8 nucleoli nucleolus NNS cord-337137-0ey40gzw 83 9 are be VBP cord-337137-0ey40gzw 83 10 often often RB cord-337137-0ey40gzw 83 11 seen see VBN cord-337137-0ey40gzw 83 12 and and CC cord-337137-0ey40gzw 83 13 some some DT cord-337137-0ey40gzw 83 14 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 83 15 coalesce coalesce VBP cord-337137-0ey40gzw 83 16 into into IN cord-337137-0ey40gzw 83 17 syncytial syncytial JJ cord-337137-0ey40gzw 83 18 multi multi JJ cord-337137-0ey40gzw 83 19 - - JJ cord-337137-0ey40gzw 83 20 nucleated nucleated JJ cord-337137-0ey40gzw 83 21 cells cell NNS cord-337137-0ey40gzw 83 22 ( ( -LRB- cord-337137-0ey40gzw 83 23 G g NN cord-337137-0ey40gzw 83 24 , , , cord-337137-0ey40gzw 83 25 H&E H&E NNP cord-337137-0ey40gzw 83 26 , , , cord-337137-0ey40gzw 83 27 original original JJ cord-337137-0ey40gzw 83 28 magnification magnification NN cord-337137-0ey40gzw 83 29 ×600 ×600 NN cord-337137-0ey40gzw 83 30 ) ) -RRB- cord-337137-0ey40gzw 83 31 . . . cord-337137-0ey40gzw 84 1 Multi multi JJ cord-337137-0ey40gzw 84 2 - - JJ cord-337137-0ey40gzw 84 3 nucleated nucleated JJ cord-337137-0ey40gzw 84 4 histiocytes histiocyte NNS cord-337137-0ey40gzw 84 5 may may MD cord-337137-0ey40gzw 84 6 also also RB cord-337137-0ey40gzw 84 7 be be VB cord-337137-0ey40gzw 84 8 found find VBN cord-337137-0ey40gzw 84 9 ( ( -LRB- cord-337137-0ey40gzw 84 10 H h NN cord-337137-0ey40gzw 84 11 , , , cord-337137-0ey40gzw 84 12 H&E H&E NNP cord-337137-0ey40gzw 84 13 , , , cord-337137-0ey40gzw 84 14 original original JJ cord-337137-0ey40gzw 84 15 magnification magnification NN cord-337137-0ey40gzw 84 16 ×600 ×600 NN cord-337137-0ey40gzw 84 17 ) ) -RRB- cord-337137-0ey40gzw 84 18 . . . cord-337137-0ey40gzw 85 1 SARS SARS NNP cord-337137-0ey40gzw 85 2 - - HYPH cord-337137-0ey40gzw 85 3 CoV CoV NNP cord-337137-0ey40gzw 85 4 can can MD cord-337137-0ey40gzw 85 5 be be VB cord-337137-0ey40gzw 85 6 detected detect VBN cord-337137-0ey40gzw 85 7 in in IN cord-337137-0ey40gzw 85 8 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 85 9 by by IN cord-337137-0ey40gzw 85 10 in in IN cord-337137-0ey40gzw 85 11 situ situ NN cord-337137-0ey40gzw 85 12 hybridization hybridization NN cord-337137-0ey40gzw 85 13 ( ( -LRB- cord-337137-0ey40gzw 85 14 I -PRON- PRP cord-337137-0ey40gzw 85 15 , , , cord-337137-0ey40gzw 85 16 using use VBG cord-337137-0ey40gzw 85 17 a a DT cord-337137-0ey40gzw 85 18 DNA dna NN cord-337137-0ey40gzw 85 19 probe probe NN cord-337137-0ey40gzw 85 20 against against IN cord-337137-0ey40gzw 85 21 the the DT cord-337137-0ey40gzw 85 22 M M NNP cord-337137-0ey40gzw 85 23 gene gene NN cord-337137-0ey40gzw 85 24 , , , cord-337137-0ey40gzw 85 25 original original JJ cord-337137-0ey40gzw 85 26 magnification magnification NN cord-337137-0ey40gzw 85 27 ×600 ×600 . cord-337137-0ey40gzw 85 28 [ [ -LRB- cord-337137-0ey40gzw 85 29 22 22 CD cord-337137-0ey40gzw 85 30 ] ] -RRB- cord-337137-0ey40gzw 85 31 ) ) -RRB- cord-337137-0ey40gzw 85 32 . . . cord-337137-0ey40gzw 86 1 A a DT cord-337137-0ey40gzw 86 2 large large JJ cord-337137-0ey40gzw 86 3 array array NN cord-337137-0ey40gzw 86 4 of of IN cord-337137-0ey40gzw 86 5 antibodies antibody NNS cord-337137-0ey40gzw 86 6 against against IN cord-337137-0ey40gzw 86 7 the the DT cord-337137-0ey40gzw 86 8 viral viral JJ cord-337137-0ey40gzw 86 9 proteins protein NNS cord-337137-0ey40gzw 86 10 including include VBG cord-337137-0ey40gzw 86 11 nucleocapsid nucleocapsid NN cord-337137-0ey40gzw 86 12 N n CD cord-337137-0ey40gzw 86 13 , , , cord-337137-0ey40gzw 86 14 spike spike NN cord-337137-0ey40gzw 86 15 S s NN cord-337137-0ey40gzw 86 16 , , , cord-337137-0ey40gzw 86 17 membrane membrane NN cord-337137-0ey40gzw 86 18 M M NNP cord-337137-0ey40gzw 86 19 , , , cord-337137-0ey40gzw 86 20 and and CC cord-337137-0ey40gzw 86 21 SARS-3a SARS-3a NNP cord-337137-0ey40gzw 86 22 [ [ -LRB- cord-337137-0ey40gzw 86 23 23 23 CD cord-337137-0ey40gzw 86 24 ] ] -RRB- cord-337137-0ey40gzw 86 25 , , , cord-337137-0ey40gzw 86 26 has have VBZ cord-337137-0ey40gzw 86 27 been be VBN cord-337137-0ey40gzw 86 28 developed develop VBN cord-337137-0ey40gzw 86 29 for for IN cord-337137-0ey40gzw 86 30 the the DT cord-337137-0ey40gzw 86 31 detection detection NN cord-337137-0ey40gzw 86 32 of of IN cord-337137-0ey40gzw 86 33 SARS SARS NNP cord-337137-0ey40gzw 86 34 - - HYPH cord-337137-0ey40gzw 86 35 CoV CoV NNP cord-337137-0ey40gzw 86 36 in in IN cord-337137-0ey40gzw 86 37 formalin formalin NN cord-337137-0ey40gzw 86 38 - - HYPH cord-337137-0ey40gzw 86 39 fixed fix VBN cord-337137-0ey40gzw 86 40 , , , cord-337137-0ey40gzw 86 41 paraffin paraffin NN cord-337137-0ey40gzw 86 42 - - HYPH cord-337137-0ey40gzw 86 43 embedded embed VBN cord-337137-0ey40gzw 86 44 tissue tissue NN cord-337137-0ey40gzw 86 45 sections section NNS cord-337137-0ey40gzw 86 46 ( ( -LRB- cord-337137-0ey40gzw 86 47 J J NNP cord-337137-0ey40gzw 86 48 , , , cord-337137-0ey40gzw 86 49 showing show VBG cord-337137-0ey40gzw 86 50 immunohistochemical immunohistochemical JJ cord-337137-0ey40gzw 86 51 staining stain VBG cord-337137-0ey40gzw 86 52 with with IN cord-337137-0ey40gzw 86 53 an an DT cord-337137-0ey40gzw 86 54 anti anti JJ cord-337137-0ey40gzw 86 55 - - JJ cord-337137-0ey40gzw 86 56 peptide peptide JJ cord-337137-0ey40gzw 86 57 antibody antibody NN cord-337137-0ey40gzw 86 58 against against IN cord-337137-0ey40gzw 86 59 N n CD cord-337137-0ey40gzw 86 60 , , , cord-337137-0ey40gzw 86 61 original original JJ cord-337137-0ey40gzw 86 62 magnification magnification NN cord-337137-0ey40gzw 86 63 ×600 ×600 NN cord-337137-0ey40gzw 86 64 ) ) -RRB- cord-337137-0ey40gzw 86 65 related relate VBN cord-337137-0ey40gzw 86 66 to to IN cord-337137-0ey40gzw 86 67 differences difference NNS cord-337137-0ey40gzw 86 68 in in IN cord-337137-0ey40gzw 86 69 the the DT cord-337137-0ey40gzw 86 70 affinities affinity NNS cord-337137-0ey40gzw 86 71 of of IN cord-337137-0ey40gzw 86 72 SARS SARS NNP cord-337137-0ey40gzw 86 73 - - HYPH cord-337137-0ey40gzw 86 74 CoV CoV NNP cord-337137-0ey40gzw 86 75 for for IN cord-337137-0ey40gzw 86 76 human human JJ cord-337137-0ey40gzw 86 77 receptors receptor NNS cord-337137-0ey40gzw 86 78 and and CC cord-337137-0ey40gzw 86 79 their -PRON- PRP$ cord-337137-0ey40gzw 86 80 murine murine JJ cord-337137-0ey40gzw 86 81 homologues homologue NNS cord-337137-0ey40gzw 86 82 [ [ -LRB- cord-337137-0ey40gzw 86 83 37 37 CD cord-337137-0ey40gzw 86 84 ] ] -RRB- cord-337137-0ey40gzw 86 85 . . . cord-337137-0ey40gzw 87 1 SARS SARS NNP cord-337137-0ey40gzw 87 2 - - HYPH cord-337137-0ey40gzw 87 3 CoV CoV NNP cord-337137-0ey40gzw 87 4 uses use VBZ cord-337137-0ey40gzw 87 5 a a DT cord-337137-0ey40gzw 87 6 protector protector NN cord-337137-0ey40gzw 87 7 of of IN cord-337137-0ey40gzw 87 8 lung lung NN cord-337137-0ey40gzw 87 9 damage damage NN cord-337137-0ey40gzw 87 10 , , , cord-337137-0ey40gzw 87 11 angiotensin angiotensin NN cord-337137-0ey40gzw 87 12 - - HYPH cord-337137-0ey40gzw 87 13 converting convert VBG cord-337137-0ey40gzw 87 14 enzyme enzyme NN cord-337137-0ey40gzw 87 15 2 2 CD cord-337137-0ey40gzw 87 16 , , , cord-337137-0ey40gzw 87 17 as as IN cord-337137-0ey40gzw 87 18 a a DT cord-337137-0ey40gzw 87 19 receptor receptor NN cord-337137-0ey40gzw 87 20 Characterization characterization NN cord-337137-0ey40gzw 87 21 of of IN cord-337137-0ey40gzw 87 22 the the DT cord-337137-0ey40gzw 87 23 functional functional JJ cord-337137-0ey40gzw 87 24 cellular cellular JJ cord-337137-0ey40gzw 87 25 receptor receptor NN cord-337137-0ey40gzw 87 26 of of IN cord-337137-0ey40gzw 87 27 SARS SARS NNP cord-337137-0ey40gzw 87 28 - - HYPH cord-337137-0ey40gzw 87 29 CoV CoV NNP cord-337137-0ey40gzw 87 30 provides provide VBZ cord-337137-0ey40gzw 87 31 important important JJ cord-337137-0ey40gzw 87 32 clues clue NNS cord-337137-0ey40gzw 87 33 to to IN cord-337137-0ey40gzw 87 34 the the DT cord-337137-0ey40gzw 87 35 pathogenesis pathogenesis NN cord-337137-0ey40gzw 87 36 of of IN cord-337137-0ey40gzw 87 37 SARS SARS NNP cord-337137-0ey40gzw 87 38 . . . cord-337137-0ey40gzw 88 1 Angiotensin angiotensin NN cord-337137-0ey40gzw 88 2 - - HYPH cord-337137-0ey40gzw 88 3 converting convert VBG cord-337137-0ey40gzw 88 4 enzyme enzyme NN cord-337137-0ey40gzw 88 5 2 2 CD cord-337137-0ey40gzw 88 6 ( ( -LRB- cord-337137-0ey40gzw 88 7 ACE2 ACE2 NNP cord-337137-0ey40gzw 88 8 ) ) -RRB- cord-337137-0ey40gzw 88 9 interacts interact VBZ cord-337137-0ey40gzw 88 10 directly directly RB cord-337137-0ey40gzw 88 11 with with IN cord-337137-0ey40gzw 88 12 the the DT cord-337137-0ey40gzw 88 13 Spike spike NN cord-337137-0ey40gzw 88 14 ( ( -LRB- cord-337137-0ey40gzw 88 15 S S NNP cord-337137-0ey40gzw 88 16 ) ) -RRB- cord-337137-0ey40gzw 88 17 proteins protein NNS cord-337137-0ey40gzw 88 18 of of IN cord-337137-0ey40gzw 88 19 the the DT cord-337137-0ey40gzw 88 20 SARS SARS NNP cord-337137-0ey40gzw 88 21 - - HYPH cord-337137-0ey40gzw 88 22 CoV CoV NNP cord-337137-0ey40gzw 88 23 [ [ -LRB- cord-337137-0ey40gzw 88 24 38 38 CD cord-337137-0ey40gzw 88 25 ] ] -RRB- cord-337137-0ey40gzw 88 26 [ [ -LRB- cord-337137-0ey40gzw 88 27 39 39 CD cord-337137-0ey40gzw 88 28 ] ] -RRB- cord-337137-0ey40gzw 88 29 [ [ -LRB- cord-337137-0ey40gzw 88 30 40 40 CD cord-337137-0ey40gzw 88 31 ] ] -RRB- cord-337137-0ey40gzw 89 1 [ [ -LRB- cord-337137-0ey40gzw 89 2 41 41 CD cord-337137-0ey40gzw 89 3 ] ] -RRB- cord-337137-0ey40gzw 89 4 [ [ -LRB- cord-337137-0ey40gzw 89 5 42 42 CD cord-337137-0ey40gzw 89 6 ] ] -RRB- cord-337137-0ey40gzw 89 7 . . . cord-337137-0ey40gzw 90 1 The the DT cord-337137-0ey40gzw 90 2 level level NN cord-337137-0ey40gzw 90 3 of of IN cord-337137-0ey40gzw 90 4 expression expression NN cord-337137-0ey40gzw 90 5 of of IN cord-337137-0ey40gzw 90 6 ACE2 ACE2 NNP cord-337137-0ey40gzw 90 7 correlates correlate VBZ cord-337137-0ey40gzw 90 8 with with IN cord-337137-0ey40gzw 90 9 the the DT cord-337137-0ey40gzw 90 10 efficiency efficiency NN cord-337137-0ey40gzw 90 11 of of IN cord-337137-0ey40gzw 90 12 SARS SARS NNP cord-337137-0ey40gzw 90 13 - - HYPH cord-337137-0ey40gzw 90 14 CoV CoV NNP cord-337137-0ey40gzw 90 15 infection infection NN cord-337137-0ey40gzw 90 16 in in IN cord-337137-0ey40gzw 90 17 cell cell NN cord-337137-0ey40gzw 90 18 culture culture NN cord-337137-0ey40gzw 90 19 models model NNS cord-337137-0ey40gzw 90 20 [ [ -LRB- cord-337137-0ey40gzw 90 21 42 42 CD cord-337137-0ey40gzw 90 22 ] ] -RRB- cord-337137-0ey40gzw 91 1 [ [ -LRB- cord-337137-0ey40gzw 91 2 43 43 CD cord-337137-0ey40gzw 91 3 ] ] -RRB- cord-337137-0ey40gzw 91 4 [ [ -LRB- cord-337137-0ey40gzw 91 5 44 44 CD cord-337137-0ey40gzw 91 6 ] ] -RRB- cord-337137-0ey40gzw 91 7 . . . cord-337137-0ey40gzw 92 1 ACE2 ACE2 NNP cord-337137-0ey40gzw 92 2 proteins protein NNS cord-337137-0ey40gzw 92 3 are be VBP cord-337137-0ey40gzw 92 4 expressed express VBN cord-337137-0ey40gzw 92 5 by by IN cord-337137-0ey40gzw 92 6 alveolar alveolar JJ cord-337137-0ey40gzw 92 7 epithelial epithelial JJ cord-337137-0ey40gzw 92 8 cells cell NNS cord-337137-0ey40gzw 92 9 and and CC cord-337137-0ey40gzw 92 10 by by IN cord-337137-0ey40gzw 92 11 surface surface NN cord-337137-0ey40gzw 92 12 enterocytes enterocyte NNS cord-337137-0ey40gzw 92 13 of of IN cord-337137-0ey40gzw 92 14 the the DT cord-337137-0ey40gzw 92 15 small small JJ cord-337137-0ey40gzw 92 16 intestine intestine NN cord-337137-0ey40gzw 92 17 [ [ -LRB- cord-337137-0ey40gzw 92 18 45 45 CD cord-337137-0ey40gzw 92 19 ] ] -RRB- cord-337137-0ey40gzw 92 20 , , , cord-337137-0ey40gzw 92 21 which which WDT cord-337137-0ey40gzw 92 22 are be VBP cord-337137-0ey40gzw 92 23 the the DT cord-337137-0ey40gzw 92 24 primary primary JJ cord-337137-0ey40gzw 92 25 target target NN cord-337137-0ey40gzw 92 26 cells cell NNS cord-337137-0ey40gzw 92 27 of of IN cord-337137-0ey40gzw 92 28 SARS SARS NNP cord-337137-0ey40gzw 92 29 - - HYPH cord-337137-0ey40gzw 92 30 CoV. CoV. NNP cord-337137-0ey40gzw 92 31 Studies Studies NNPS cord-337137-0ey40gzw 92 32 in in IN cord-337137-0ey40gzw 92 33 the the DT cord-337137-0ey40gzw 92 34 intestine intestine NN cord-337137-0ey40gzw 92 35 cell cell NN cord-337137-0ey40gzw 92 36 culture culture NN cord-337137-0ey40gzw 92 37 model model NN cord-337137-0ey40gzw 92 38 , , , cord-337137-0ey40gzw 92 39 however however RB cord-337137-0ey40gzw 92 40 , , , cord-337137-0ey40gzw 92 41 suggested suggest VBD cord-337137-0ey40gzw 92 42 that that IN cord-337137-0ey40gzw 92 43 , , , cord-337137-0ey40gzw 92 44 in in IN cord-337137-0ey40gzw 92 45 addition addition NN cord-337137-0ey40gzw 92 46 to to IN cord-337137-0ey40gzw 92 47 ACE2 ACE2 NNP cord-337137-0ey40gzw 92 48 , , , cord-337137-0ey40gzw 92 49 unknown unknown JJ cord-337137-0ey40gzw 92 50 co co NNS cord-337137-0ey40gzw 92 51 - - NNS cord-337137-0ey40gzw 92 52 factors factor NNS cord-337137-0ey40gzw 92 53 or or CC cord-337137-0ey40gzw 92 54 coreceptors coreceptor NNS cord-337137-0ey40gzw 92 55 are be VBP cord-337137-0ey40gzw 92 56 required require VBN cord-337137-0ey40gzw 92 57 to to TO cord-337137-0ey40gzw 92 58 convey convey VB cord-337137-0ey40gzw 92 59 infectivity infectivity NN cord-337137-0ey40gzw 92 60 [ [ -LRB- cord-337137-0ey40gzw 92 61 46 46 CD cord-337137-0ey40gzw 92 62 ] ] -RRB- cord-337137-0ey40gzw 92 63 . . . cord-337137-0ey40gzw 93 1 In in IN cord-337137-0ey40gzw 93 2 addition addition NN cord-337137-0ey40gzw 93 3 to to IN cord-337137-0ey40gzw 93 4 being be VBG cord-337137-0ey40gzw 93 5 a a DT cord-337137-0ey40gzw 93 6 cellular cellular JJ cord-337137-0ey40gzw 93 7 receptor receptor NN cord-337137-0ey40gzw 93 8 , , , cord-337137-0ey40gzw 93 9 ACE2 ACE2 NNP cord-337137-0ey40gzw 93 10 may may MD cord-337137-0ey40gzw 93 11 contribute contribute VB cord-337137-0ey40gzw 93 12 to to IN cord-337137-0ey40gzw 93 13 the the DT cord-337137-0ey40gzw 93 14 pathogenesis pathogenesis NN cord-337137-0ey40gzw 93 15 of of IN cord-337137-0ey40gzw 93 16 DAD DAD NNP cord-337137-0ey40gzw 93 17 in in IN cord-337137-0ey40gzw 93 18 SARS SARS NNP cord-337137-0ey40gzw 93 19 through through IN cord-337137-0ey40gzw 93 20 its -PRON- PRP$ cord-337137-0ey40gzw 93 21 role role NN cord-337137-0ey40gzw 93 22 in in IN cord-337137-0ey40gzw 93 23 the the DT cord-337137-0ey40gzw 93 24 tissue tissue NN cord-337137-0ey40gzw 93 25 renin renin NN cord-337137-0ey40gzw 93 26 - - HYPH cord-337137-0ey40gzw 93 27 angiotensin angiotensin NN cord-337137-0ey40gzw 93 28 system system NN cord-337137-0ey40gzw 93 29 . . . cord-337137-0ey40gzw 94 1 In in IN cord-337137-0ey40gzw 94 2 a a DT cord-337137-0ey40gzw 94 3 mouse mouse NN cord-337137-0ey40gzw 94 4 model model NN cord-337137-0ey40gzw 94 5 of of IN cord-337137-0ey40gzw 94 6 alveolar alveolar JJ cord-337137-0ey40gzw 94 7 damage damage NN cord-337137-0ey40gzw 94 8 induced induce VBN cord-337137-0ey40gzw 94 9 by by IN cord-337137-0ey40gzw 94 10 acid acid JJ cord-337137-0ey40gzw 94 11 aspiration aspiration NN cord-337137-0ey40gzw 94 12 , , , cord-337137-0ey40gzw 94 13 the the DT cord-337137-0ey40gzw 94 14 balance balance NN cord-337137-0ey40gzw 94 15 of of IN cord-337137-0ey40gzw 94 16 the the DT cord-337137-0ey40gzw 94 17 renin renin NN cord-337137-0ey40gzw 94 18 - - HYPH cord-337137-0ey40gzw 94 19 angiotensin angiotensin NN cord-337137-0ey40gzw 94 20 system system NN cord-337137-0ey40gzw 94 21 appears appear VBZ cord-337137-0ey40gzw 94 22 to to TO cord-337137-0ey40gzw 94 23 affect affect VB cord-337137-0ey40gzw 94 24 the the DT cord-337137-0ey40gzw 94 25 development development NN cord-337137-0ey40gzw 94 26 of of IN cord-337137-0ey40gzw 94 27 DAD DAD NNP cord-337137-0ey40gzw 94 28 . . . cord-337137-0ey40gzw 95 1 ACE2 ACE2 NNP cord-337137-0ey40gzw 95 2 , , , cord-337137-0ey40gzw 95 3 which which WDT cord-337137-0ey40gzw 95 4 acts act VBZ cord-337137-0ey40gzw 95 5 as as IN cord-337137-0ey40gzw 95 6 a a DT cord-337137-0ey40gzw 95 7 negative negative JJ cord-337137-0ey40gzw 95 8 regulator regulator NN cord-337137-0ey40gzw 95 9 of of IN cord-337137-0ey40gzw 95 10 the the DT cord-337137-0ey40gzw 95 11 local local JJ cord-337137-0ey40gzw 95 12 renin renin NN cord-337137-0ey40gzw 95 13 - - HYPH cord-337137-0ey40gzw 95 14 angiotensin angiotensin NN cord-337137-0ey40gzw 95 15 system system NN cord-337137-0ey40gzw 95 16 , , , cord-337137-0ey40gzw 95 17 protects protect VBZ cord-337137-0ey40gzw 95 18 the the DT cord-337137-0ey40gzw 95 19 mouse mouse NN cord-337137-0ey40gzw 95 20 lung lung NN cord-337137-0ey40gzw 95 21 against against IN cord-337137-0ey40gzw 95 22 experimental experimental JJ cord-337137-0ey40gzw 95 23 damage damage NN cord-337137-0ey40gzw 95 24 [ [ -LRB- cord-337137-0ey40gzw 95 25 47 47 CD cord-337137-0ey40gzw 95 26 , , , cord-337137-0ey40gzw 95 27 48 48 CD cord-337137-0ey40gzw 95 28 ] ] -RRB- cord-337137-0ey40gzw 95 29 . . . cord-337137-0ey40gzw 96 1 SARS SARS NNP cord-337137-0ey40gzw 96 2 - - HYPH cord-337137-0ey40gzw 96 3 CoV CoV NNP cord-337137-0ey40gzw 96 4 co co NN cord-337137-0ey40gzw 96 5 - - NN cord-337137-0ey40gzw 96 6 infection infection NN cord-337137-0ey40gzw 96 7 in in IN cord-337137-0ey40gzw 96 8 these these DT cord-337137-0ey40gzw 96 9 damaged damage VBN cord-337137-0ey40gzw 96 10 animals animal NNS cord-337137-0ey40gzw 96 11 downregulates downregulate VBZ cord-337137-0ey40gzw 96 12 ACE2 ACE2 NNP cord-337137-0ey40gzw 96 13 in in IN cord-337137-0ey40gzw 96 14 the the DT cord-337137-0ey40gzw 96 15 lungs lung NNS cord-337137-0ey40gzw 96 16 of of IN cord-337137-0ey40gzw 96 17 infected infected JJ cord-337137-0ey40gzw 96 18 mice mouse NNS cord-337137-0ey40gzw 96 19 and and CC cord-337137-0ey40gzw 96 20 the the DT cord-337137-0ey40gzw 96 21 severity severity NN cord-337137-0ey40gzw 96 22 of of IN cord-337137-0ey40gzw 96 23 lung lung NN cord-337137-0ey40gzw 96 24 damage damage NN cord-337137-0ey40gzw 96 25 can can MD cord-337137-0ey40gzw 96 26 be be VB cord-337137-0ey40gzw 96 27 alleviated alleviate VBN cord-337137-0ey40gzw 96 28 by by IN cord-337137-0ey40gzw 96 29 blocking block VBG cord-337137-0ey40gzw 96 30 the the DT cord-337137-0ey40gzw 96 31 system system NN cord-337137-0ey40gzw 96 32 [ [ -LRB- cord-337137-0ey40gzw 96 33 49 49 CD cord-337137-0ey40gzw 96 34 ] ] -RRB- cord-337137-0ey40gzw 96 35 . . . cord-337137-0ey40gzw 97 1 Exciting exciting JJ cord-337137-0ey40gzw 97 2 as as IN cord-337137-0ey40gzw 97 3 these these DT cord-337137-0ey40gzw 97 4 findings finding NNS cord-337137-0ey40gzw 97 5 appear appear VBP cord-337137-0ey40gzw 97 6 , , , cord-337137-0ey40gzw 97 7 the the DT cord-337137-0ey40gzw 97 8 case case NN cord-337137-0ey40gzw 97 9 of of IN cord-337137-0ey40gzw 97 10 a a DT cord-337137-0ey40gzw 97 11 new new JJ cord-337137-0ey40gzw 97 12 coronavirus coronavirus NN cord-337137-0ey40gzw 97 13 , , , cord-337137-0ey40gzw 97 14 NL63 NL63 NNP cord-337137-0ey40gzw 97 15 , , , cord-337137-0ey40gzw 97 16 immediately immediately RB cord-337137-0ey40gzw 97 17 provides provide VBZ cord-337137-0ey40gzw 97 18 an an DT cord-337137-0ey40gzw 97 19 example example NN cord-337137-0ey40gzw 97 20 that that IN cord-337137-0ey40gzw 97 21 other other JJ cord-337137-0ey40gzw 97 22 factors factor NNS cord-337137-0ey40gzw 97 23 are be VBP cord-337137-0ey40gzw 97 24 acting act VBG cord-337137-0ey40gzw 97 25 in in IN cord-337137-0ey40gzw 97 26 the the DT cord-337137-0ey40gzw 97 27 overall overall JJ cord-337137-0ey40gzw 97 28 mechanism mechanism NN cord-337137-0ey40gzw 97 29 of of IN cord-337137-0ey40gzw 97 30 lung lung NN cord-337137-0ey40gzw 97 31 damage damage NN cord-337137-0ey40gzw 97 32 . . . cord-337137-0ey40gzw 98 1 NL63 NL63 NNP cord-337137-0ey40gzw 98 2 utilizes utilize VBZ cord-337137-0ey40gzw 98 3 the the DT cord-337137-0ey40gzw 98 4 same same JJ cord-337137-0ey40gzw 98 5 ACE2 ACE2 NNP cord-337137-0ey40gzw 98 6 protein protein NN cord-337137-0ey40gzw 98 7 as as IN cord-337137-0ey40gzw 98 8 its -PRON- PRP$ cord-337137-0ey40gzw 98 9 receptor receptor NN cord-337137-0ey40gzw 98 10 in in IN cord-337137-0ey40gzw 98 11 the the DT cord-337137-0ey40gzw 98 12 lung lung NN cord-337137-0ey40gzw 98 13 . . . cord-337137-0ey40gzw 99 1 However however RB cord-337137-0ey40gzw 99 2 , , , cord-337137-0ey40gzw 99 3 infection infection NN cord-337137-0ey40gzw 99 4 with with IN cord-337137-0ey40gzw 99 5 NL63 NL63 NNP cord-337137-0ey40gzw 99 6 results result NNS cord-337137-0ey40gzw 99 7 in in IN cord-337137-0ey40gzw 99 8 only only JJ cord-337137-0ey40gzw 99 9 minor minor JJ cord-337137-0ey40gzw 99 10 cold cold JJ cord-337137-0ey40gzw 99 11 symptoms symptom NNS cord-337137-0ey40gzw 99 12 and and CC cord-337137-0ey40gzw 99 13 alveolar alveolar JJ cord-337137-0ey40gzw 99 14 damage damage NN cord-337137-0ey40gzw 99 15 is be VBZ cord-337137-0ey40gzw 99 16 rare rare JJ cord-337137-0ey40gzw 99 17 [ [ -LRB- cord-337137-0ey40gzw 99 18 50 50 CD cord-337137-0ey40gzw 99 19 ] ] -RRB- cord-337137-0ey40gzw 99 20 . . . cord-337137-0ey40gzw 100 1 The the DT cord-337137-0ey40gzw 100 2 insert insert JJ cord-337137-0ey40gzw 100 3 / / SYM cord-337137-0ey40gzw 100 4 deletion deletion NN cord-337137-0ey40gzw 100 5 genotype genotype NN cord-337137-0ey40gzw 100 6 of of IN cord-337137-0ey40gzw 100 7 the the DT cord-337137-0ey40gzw 100 8 ACE ACE NNP cord-337137-0ey40gzw 100 9 gene gene NN cord-337137-0ey40gzw 100 10 was be VBD cord-337137-0ey40gzw 100 11 associated associate VBN cord-337137-0ey40gzw 100 12 with with IN cord-337137-0ey40gzw 100 13 DAD DAD NNP cord-337137-0ey40gzw 100 14 after after IN cord-337137-0ey40gzw 100 15 SARS SARS NNP cord-337137-0ey40gzw 100 16 - - HYPH cord-337137-0ey40gzw 100 17 CoV CoV NNP cord-337137-0ey40gzw 100 18 infection infection NN cord-337137-0ey40gzw 100 19 in in IN cord-337137-0ey40gzw 100 20 a a DT cord-337137-0ey40gzw 100 21 small small JJ cord-337137-0ey40gzw 100 22 cohort cohort NN cord-337137-0ey40gzw 100 23 of of IN cord-337137-0ey40gzw 100 24 44 44 CD cord-337137-0ey40gzw 100 25 patients patient NNS cord-337137-0ey40gzw 100 26 [ [ -LRB- cord-337137-0ey40gzw 100 27 51 51 CD cord-337137-0ey40gzw 100 28 ] ] -RRB- cord-337137-0ey40gzw 100 29 . . . cord-337137-0ey40gzw 101 1 This this DT cord-337137-0ey40gzw 101 2 association association NN cord-337137-0ey40gzw 101 3 was be VBD cord-337137-0ey40gzw 101 4 , , , cord-337137-0ey40gzw 101 5 however however RB cord-337137-0ey40gzw 101 6 , , , cord-337137-0ey40gzw 101 7 not not RB cord-337137-0ey40gzw 101 8 replicated replicate VBN cord-337137-0ey40gzw 101 9 subsequently subsequently RB cord-337137-0ey40gzw 101 10 in in IN cord-337137-0ey40gzw 101 11 a a DT cord-337137-0ey40gzw 101 12 larger large JJR cord-337137-0ey40gzw 101 13 series series NN cord-337137-0ey40gzw 101 14 [ [ -LRB- cord-337137-0ey40gzw 101 15 52 52 CD cord-337137-0ey40gzw 101 16 ] ] -RRB- cord-337137-0ey40gzw 101 17 . . . cord-337137-0ey40gzw 102 1 We -PRON- PRP cord-337137-0ey40gzw 102 2 also also RB cord-337137-0ey40gzw 102 3 could could MD cord-337137-0ey40gzw 102 4 not not RB cord-337137-0ey40gzw 102 5 detect detect VB cord-337137-0ey40gzw 102 6 any any DT cord-337137-0ey40gzw 102 7 association association NN cord-337137-0ey40gzw 102 8 between between IN cord-337137-0ey40gzw 102 9 the the DT cord-337137-0ey40gzw 102 10 ACE2 ACE2 NNP cord-337137-0ey40gzw 102 11 genotype genotype NN cord-337137-0ey40gzw 102 12 and and CC cord-337137-0ey40gzw 102 13 disease disease NN cord-337137-0ey40gzw 102 14 severity severity NN cord-337137-0ey40gzw 102 15 in in IN cord-337137-0ey40gzw 102 16 SARS SARS NNP cord-337137-0ey40gzw 102 17 - - HYPH cord-337137-0ey40gzw 102 18 CoV CoV NNP cord-337137-0ey40gzw 102 19 infection infection NN cord-337137-0ey40gzw 102 20 [ [ -LRB- cord-337137-0ey40gzw 102 21 53 53 CD cord-337137-0ey40gzw 102 22 ] ] -RRB- cord-337137-0ey40gzw 102 23 . . . cord-337137-0ey40gzw 103 1 SARS SARS NNP cord-337137-0ey40gzw 103 2 - - HYPH cord-337137-0ey40gzw 103 3 CoV CoV NNP cord-337137-0ey40gzw 103 4 may may MD cord-337137-0ey40gzw 103 5 also also RB cord-337137-0ey40gzw 103 6 use use VB cord-337137-0ey40gzw 103 7 the the DT cord-337137-0ey40gzw 103 8 C c NN cord-337137-0ey40gzw 103 9 - - HYPH cord-337137-0ey40gzw 103 10 type type NN cord-337137-0ey40gzw 103 11 lectins lectin NNS cord-337137-0ey40gzw 103 12 as as IN cord-337137-0ey40gzw 103 13 receptors receptor NNS cord-337137-0ey40gzw 103 14 for for IN cord-337137-0ey40gzw 103 15 infecting infect VBG cord-337137-0ey40gzw 103 16 immune immune JJ cord-337137-0ey40gzw 103 17 cells cell NNS cord-337137-0ey40gzw 103 18 C c NN cord-337137-0ey40gzw 103 19 - - HYPH cord-337137-0ey40gzw 103 20 type type NN cord-337137-0ey40gzw 103 21 lectins lectin NNS cord-337137-0ey40gzw 103 22 , , , cord-337137-0ey40gzw 103 23 including include VBG cord-337137-0ey40gzw 103 24 CD209 cd209 NN cord-337137-0ey40gzw 103 25 and and CC cord-337137-0ey40gzw 103 26 CD209L CD209L NNS cord-337137-0ey40gzw 103 27 , , , cord-337137-0ey40gzw 103 28 are be VBP cord-337137-0ey40gzw 103 29 also also RB cord-337137-0ey40gzw 103 30 SARS SARS NNP cord-337137-0ey40gzw 103 31 - - HYPH cord-337137-0ey40gzw 103 32 COV COV NNP cord-337137-0ey40gzw 103 33 receptors receptor NNS cord-337137-0ey40gzw 103 34 : : : cord-337137-0ey40gzw 103 35 these these DT cord-337137-0ey40gzw 103 36 were be VBD cord-337137-0ey40gzw 103 37 identified identify VBN cord-337137-0ey40gzw 103 38 through through IN cord-337137-0ey40gzw 103 39 the the DT cord-337137-0ey40gzw 103 40 study study NN cord-337137-0ey40gzw 103 41 of of IN cord-337137-0ey40gzw 103 42 proteins protein NNS cord-337137-0ey40gzw 103 43 that that WDT cord-337137-0ey40gzw 103 44 interact interact VBP cord-337137-0ey40gzw 103 45 with with IN cord-337137-0ey40gzw 103 46 the the DT cord-337137-0ey40gzw 103 47 S s NN cord-337137-0ey40gzw 103 48 ( ( -LRB- cord-337137-0ey40gzw 103 49 Spike spike NN cord-337137-0ey40gzw 103 50 ) ) -RRB- cord-337137-0ey40gzw 103 51 protein protein NN cord-337137-0ey40gzw 103 52 . . . cord-337137-0ey40gzw 104 1 CD209 CD209 NNP cord-337137-0ey40gzw 104 2 , , , cord-337137-0ey40gzw 104 3 also also RB cord-337137-0ey40gzw 104 4 known know VBN cord-337137-0ey40gzw 104 5 as as IN cord-337137-0ey40gzw 104 6 dendritic dendritic JJ cord-337137-0ey40gzw 104 7 cell cell NN cord-337137-0ey40gzw 104 8 - - HYPH cord-337137-0ey40gzw 104 9 specific specific JJ cord-337137-0ey40gzw 104 10 intercellular intercellular JJ cord-337137-0ey40gzw 104 11 adhesion adhesion NN cord-337137-0ey40gzw 104 12 molecule molecule NN cord-337137-0ey40gzw 104 13 - - HYPH cord-337137-0ey40gzw 104 14 grabbing grab VBG cord-337137-0ey40gzw 104 15 non non JJ cord-337137-0ey40gzw 104 16 - - JJ cord-337137-0ey40gzw 104 17 integrin integrin JJ cord-337137-0ey40gzw 104 18 ( ( -LRB- cord-337137-0ey40gzw 104 19 DC DC NNP cord-337137-0ey40gzw 104 20 - - HYPH cord-337137-0ey40gzw 104 21 SIGN SIGN NNP cord-337137-0ey40gzw 104 22 ) ) -RRB- cord-337137-0ey40gzw 104 23 , , , cord-337137-0ey40gzw 104 24 was be VBD cord-337137-0ey40gzw 104 25 shown show VBN cord-337137-0ey40gzw 104 26 to to TO cord-337137-0ey40gzw 104 27 mediate mediate VB cord-337137-0ey40gzw 104 28 viral viral JJ cord-337137-0ey40gzw 104 29 entry entry NN cord-337137-0ey40gzw 104 30 in in IN cord-337137-0ey40gzw 104 31 a a DT cord-337137-0ey40gzw 104 32 lentiviral lentiviral JJ cord-337137-0ey40gzw 104 33 pseudo pseudo JJ cord-337137-0ey40gzw 104 34 - - JJ cord-337137-0ey40gzw 104 35 type type JJ cord-337137-0ey40gzw 104 36 experimental experimental JJ cord-337137-0ey40gzw 104 37 model model NN cord-337137-0ey40gzw 104 38 [ [ -LRB- cord-337137-0ey40gzw 104 39 54 54 CD cord-337137-0ey40gzw 104 40 ] ] -RRB- cord-337137-0ey40gzw 104 41 . . . cord-337137-0ey40gzw 105 1 In in IN cord-337137-0ey40gzw 105 2 Chinese chinese JJ cord-337137-0ey40gzw 105 3 hamster hamster NN cord-337137-0ey40gzw 105 4 ovary ovary NN cord-337137-0ey40gzw 105 5 ( ( -LRB- cord-337137-0ey40gzw 105 6 CHO CHO NNP cord-337137-0ey40gzw 105 7 ) ) -RRB- cord-337137-0ey40gzw 105 8 cells cell NNS cord-337137-0ey40gzw 105 9 expressing express VBG cord-337137-0ey40gzw 105 10 a a DT cord-337137-0ey40gzw 105 11 human human JJ cord-337137-0ey40gzw 105 12 lung lung NN cord-337137-0ey40gzw 105 13 cDNA cDNA NNP cord-337137-0ey40gzw 105 14 library library NNP cord-337137-0ey40gzw 105 15 , , , cord-337137-0ey40gzw 105 16 S S NNP cord-337137-0ey40gzw 105 17 protein protein NN cord-337137-0ey40gzw 105 18 and and CC cord-337137-0ey40gzw 105 19 its -PRON- PRP$ cord-337137-0ey40gzw 105 20 fragments fragment NNS cord-337137-0ey40gzw 105 21 interacted interact VBD cord-337137-0ey40gzw 105 22 directly directly RB cord-337137-0ey40gzw 105 23 with with IN cord-337137-0ey40gzw 105 24 a a DT cord-337137-0ey40gzw 105 25 second second JJ cord-337137-0ey40gzw 105 26 related related JJ cord-337137-0ey40gzw 105 27 cell cell NN cord-337137-0ey40gzw 105 28 surface surface NN cord-337137-0ey40gzw 105 29 glycoprotein glycoprotein NN cord-337137-0ey40gzw 105 30 , , , cord-337137-0ey40gzw 105 31 CD209L CD209L NNP cord-337137-0ey40gzw 105 32 , , , cord-337137-0ey40gzw 105 33 also also RB cord-337137-0ey40gzw 105 34 known know VBN cord-337137-0ey40gzw 105 35 as as IN cord-337137-0ey40gzw 105 36 L l NN cord-337137-0ey40gzw 105 37 - - HYPH cord-337137-0ey40gzw 105 38 SIGN SIGN NNP cord-337137-0ey40gzw 105 39 or or CC cord-337137-0ey40gzw 105 40 DC DC NNP cord-337137-0ey40gzw 105 41 - - HYPH cord-337137-0ey40gzw 105 42 SIGNR SIGNR NNP cord-337137-0ey40gzw 105 43 [ [ -LRB- cord-337137-0ey40gzw 105 44 55 55 CD cord-337137-0ey40gzw 105 45 ] ] -RRB- cord-337137-0ey40gzw 105 46 . . . cord-337137-0ey40gzw 106 1 CD209L cd209l NN cord-337137-0ey40gzw 106 2 acts act NNS cord-337137-0ey40gzw 106 3 in in IN cord-337137-0ey40gzw 106 4 conjunction conjunction NN cord-337137-0ey40gzw 106 5 with with IN cord-337137-0ey40gzw 106 6 LSECtin lsectin NN cord-337137-0ey40gzw 106 7 ( ( -LRB- cord-337137-0ey40gzw 106 8 liver liver NN cord-337137-0ey40gzw 106 9 and and CC cord-337137-0ey40gzw 106 10 lymph lymph NN cord-337137-0ey40gzw 106 11 node node NN cord-337137-0ey40gzw 106 12 sinusoidal sinusoidal JJ cord-337137-0ey40gzw 106 13 endothelial endothelial JJ cord-337137-0ey40gzw 106 14 cell cell NN cord-337137-0ey40gzw 106 15 C c NN cord-337137-0ey40gzw 106 16 - - HYPH cord-337137-0ey40gzw 106 17 type type NN cord-337137-0ey40gzw 106 18 lectin lectin NN cord-337137-0ey40gzw 106 19 ) ) -RRB- cord-337137-0ey40gzw 106 20 and and CC cord-337137-0ey40gzw 106 21 enhances enhance VBZ cord-337137-0ey40gzw 106 22 viral viral JJ cord-337137-0ey40gzw 106 23 infection infection NN cord-337137-0ey40gzw 106 24 [ [ -LRB- cord-337137-0ey40gzw 106 25 56 56 CD cord-337137-0ey40gzw 106 26 ] ] -RRB- cord-337137-0ey40gzw 106 27 . . . cord-337137-0ey40gzw 107 1 Tissue tissue NN cord-337137-0ey40gzw 107 2 cultures culture NNS cord-337137-0ey40gzw 107 3 expressing express VBG cord-337137-0ey40gzw 107 4 CD209 cd209 NN cord-337137-0ey40gzw 107 5 or or CC cord-337137-0ey40gzw 107 6 CD209L CD209L NNS cord-337137-0ey40gzw 107 7 were be VBD cord-337137-0ey40gzw 107 8 also also RB cord-337137-0ey40gzw 107 9 susceptible susceptible JJ cord-337137-0ey40gzw 107 10 to to IN cord-337137-0ey40gzw 107 11 SARS SARS NNP cord-337137-0ey40gzw 107 12 - - HYPH cord-337137-0ey40gzw 107 13 CoV CoV NNP cord-337137-0ey40gzw 107 14 infection infection NN cord-337137-0ey40gzw 107 15 [ [ -LRB- cord-337137-0ey40gzw 107 16 54 54 CD cord-337137-0ey40gzw 107 17 , , , cord-337137-0ey40gzw 107 18 55 55 CD cord-337137-0ey40gzw 107 19 , , , cord-337137-0ey40gzw 107 20 57 57 CD cord-337137-0ey40gzw 107 21 ] ] -RRB- cord-337137-0ey40gzw 107 22 . . . cord-337137-0ey40gzw 108 1 The the DT cord-337137-0ey40gzw 108 2 possible possible JJ cord-337137-0ey40gzw 108 3 involvement involvement NN cord-337137-0ey40gzw 108 4 of of IN cord-337137-0ey40gzw 108 5 dendritic dendritic JJ cord-337137-0ey40gzw 108 6 cells cell NNS cord-337137-0ey40gzw 108 7 is be VBZ cord-337137-0ey40gzw 108 8 particularly particularly RB cord-337137-0ey40gzw 108 9 interesting interesting JJ cord-337137-0ey40gzw 108 10 . . . cord-337137-0ey40gzw 109 1 Although although IN cord-337137-0ey40gzw 109 2 SARS SARS NNP cord-337137-0ey40gzw 109 3 - - HYPH cord-337137-0ey40gzw 109 4 CoV CoV NNP cord-337137-0ey40gzw 109 5 does do VBZ cord-337137-0ey40gzw 109 6 not not RB cord-337137-0ey40gzw 109 7 replicate replicate VB cord-337137-0ey40gzw 109 8 in in IN cord-337137-0ey40gzw 109 9 dendritic dendritic JJ cord-337137-0ey40gzw 109 10 cells cell NNS cord-337137-0ey40gzw 109 11 , , , cord-337137-0ey40gzw 109 12 these these DT cord-337137-0ey40gzw 109 13 cells cell NNS cord-337137-0ey40gzw 109 14 may may MD cord-337137-0ey40gzw 109 15 act act VB cord-337137-0ey40gzw 109 16 as as IN cord-337137-0ey40gzw 109 17 a a DT cord-337137-0ey40gzw 109 18 reservoir reservoir NN cord-337137-0ey40gzw 109 19 and and CC cord-337137-0ey40gzw 109 20 distribute distribute VB cord-337137-0ey40gzw 109 21 the the DT cord-337137-0ey40gzw 109 22 virus virus NN cord-337137-0ey40gzw 109 23 to to IN cord-337137-0ey40gzw 109 24 other other JJ cord-337137-0ey40gzw 109 25 cell cell NN cord-337137-0ey40gzw 109 26 types type NNS cord-337137-0ey40gzw 109 27 [ [ -LRB- cord-337137-0ey40gzw 109 28 54 54 CD cord-337137-0ey40gzw 109 29 , , , cord-337137-0ey40gzw 109 30 58 58 CD cord-337137-0ey40gzw 109 31 ] ] -RRB- cord-337137-0ey40gzw 109 32 . . . cord-337137-0ey40gzw 110 1 This this DT cord-337137-0ey40gzw 110 2 is be VBZ cord-337137-0ey40gzw 110 3 an an DT cord-337137-0ey40gzw 110 4 attractive attractive JJ cord-337137-0ey40gzw 110 5 concept concept NN cord-337137-0ey40gzw 110 6 and and CC cord-337137-0ey40gzw 110 7 similar similar JJ cord-337137-0ey40gzw 110 8 biological biological JJ cord-337137-0ey40gzw 110 9 behaviours behaviour NNS cord-337137-0ey40gzw 110 10 have have VBP cord-337137-0ey40gzw 110 11 been be VBN cord-337137-0ey40gzw 110 12 proposed propose VBN cord-337137-0ey40gzw 110 13 for for IN cord-337137-0ey40gzw 110 14 human human JJ cord-337137-0ey40gzw 110 15 immunodeficiency immunodeficiency NN cord-337137-0ey40gzw 110 16 virus virus NN cord-337137-0ey40gzw 110 17 I -PRON- PRP cord-337137-0ey40gzw 110 18 ( ( -LRB- cord-337137-0ey40gzw 110 19 HIV HIV NNP cord-337137-0ey40gzw 110 20 I I NNP cord-337137-0ey40gzw 110 21 ) ) -RRB- cord-337137-0ey40gzw 110 22 [ [ -LRB- cord-337137-0ey40gzw 110 23 59 59 CD cord-337137-0ey40gzw 110 24 ] ] -RRB- cord-337137-0ey40gzw 110 25 . . . cord-337137-0ey40gzw 111 1 No no DT cord-337137-0ey40gzw 111 2 SARS SARS NNP cord-337137-0ey40gzw 111 3 - - HYPH cord-337137-0ey40gzw 111 4 CoV CoV NNP cord-337137-0ey40gzw 111 5 has have VBZ cord-337137-0ey40gzw 111 6 been be VBN cord-337137-0ey40gzw 111 7 detected detect VBN cord-337137-0ey40gzw 111 8 in in IN cord-337137-0ey40gzw 111 9 dendritic dendritic JJ cord-337137-0ey40gzw 111 10 cells cell NNS cord-337137-0ey40gzw 111 11 in in IN cord-337137-0ey40gzw 111 12 autopsy autopsy JJ cord-337137-0ey40gzw 111 13 and and CC cord-337137-0ey40gzw 111 14 biopsy biopsy NN cord-337137-0ey40gzw 111 15 studies study NNS cord-337137-0ey40gzw 111 16 reported report VBN cord-337137-0ey40gzw 111 17 so so RB cord-337137-0ey40gzw 111 18 far far RB cord-337137-0ey40gzw 111 19 . . . cord-337137-0ey40gzw 112 1 The the DT cord-337137-0ey40gzw 112 2 genome genome NN cord-337137-0ey40gzw 112 3 of of IN cord-337137-0ey40gzw 112 4 SARS SARS NNP cord-337137-0ey40gzw 112 5 - - HYPH cord-337137-0ey40gzw 112 6 CoV CoV NNP cord-337137-0ey40gzw 112 7 consists consist VBZ cord-337137-0ey40gzw 112 8 of of IN cord-337137-0ey40gzw 112 9 a a DT cord-337137-0ey40gzw 112 10 single single JJ cord-337137-0ey40gzw 112 11 27.69 27.69 CD cord-337137-0ey40gzw 112 12 kb kb NNP cord-337137-0ey40gzw 112 13 positive positive JJ cord-337137-0ey40gzw 112 14 - - HYPH cord-337137-0ey40gzw 112 15 strand strand NN cord-337137-0ey40gzw 112 16 RNA RNA NNP cord-337137-0ey40gzw 112 17 . . . cord-337137-0ey40gzw 113 1 The the DT cord-337137-0ey40gzw 113 2 genomic genomic JJ cord-337137-0ey40gzw 113 3 sequences sequence NNS cord-337137-0ey40gzw 113 4 derived derive VBN cord-337137-0ey40gzw 113 5 from from IN cord-337137-0ey40gzw 113 6 different different JJ cord-337137-0ey40gzw 113 7 phases phase NNS cord-337137-0ey40gzw 113 8 of of IN cord-337137-0ey40gzw 113 9 the the DT cord-337137-0ey40gzw 113 10 SARS SARS NNP cord-337137-0ey40gzw 113 11 epidemic epidemic NN cord-337137-0ey40gzw 113 12 revealed reveal VBD cord-337137-0ey40gzw 113 13 no no DT cord-337137-0ey40gzw 113 14 association association NN cord-337137-0ey40gzw 113 15 with with IN cord-337137-0ey40gzw 113 16 sequence sequence NN cord-337137-0ey40gzw 113 17 variation variation NN cord-337137-0ey40gzw 113 18 and and CC cord-337137-0ey40gzw 113 19 virulence virulence NN cord-337137-0ey40gzw 113 20 [ [ -LRB- cord-337137-0ey40gzw 113 21 60 60 CD cord-337137-0ey40gzw 113 22 , , , cord-337137-0ey40gzw 113 23 61 61 CD cord-337137-0ey40gzw 113 24 ] ] -RRB- cord-337137-0ey40gzw 113 25 . . . cord-337137-0ey40gzw 114 1 There there EX cord-337137-0ey40gzw 114 2 are be VBP cord-337137-0ey40gzw 114 3 two two CD cord-337137-0ey40gzw 114 4 large large JJ cord-337137-0ey40gzw 114 5 open open JJ cord-337137-0ey40gzw 114 6 reading reading NN cord-337137-0ey40gzw 114 7 frames frame NNS cord-337137-0ey40gzw 114 8 ( ( -LRB- cord-337137-0ey40gzw 114 9 ORFs ORFs NNP cord-337137-0ey40gzw 114 10 ) ) -RRB- cord-337137-0ey40gzw 114 11 and and CC cord-337137-0ey40gzw 114 12 12 12 CD cord-337137-0ey40gzw 114 13 potential potential JJ cord-337137-0ey40gzw 114 14 ORFs orfs NN cord-337137-0ey40gzw 114 15 in in IN cord-337137-0ey40gzw 114 16 the the DT cord-337137-0ey40gzw 114 17 SARS SARS NNP cord-337137-0ey40gzw 114 18 - - HYPH cord-337137-0ey40gzw 114 19 CoV CoV NNP cord-337137-0ey40gzw 114 20 genome genome NN cord-337137-0ey40gzw 114 21 . . . cord-337137-0ey40gzw 115 1 The the DT cord-337137-0ey40gzw 115 2 two two CD cord-337137-0ey40gzw 115 3 large large JJ cord-337137-0ey40gzw 115 4 ORFs orfs NN cord-337137-0ey40gzw 115 5 encode encode VBP cord-337137-0ey40gzw 115 6 non non JJ cord-337137-0ey40gzw 115 7 - - JJ cord-337137-0ey40gzw 115 8 structural structural JJ cord-337137-0ey40gzw 115 9 proteins protein NNS cord-337137-0ey40gzw 115 10 involved involve VBN cord-337137-0ey40gzw 115 11 in in IN cord-337137-0ey40gzw 115 12 replication replication NN cord-337137-0ey40gzw 115 13 . . . cord-337137-0ey40gzw 116 1 These these DT cord-337137-0ey40gzw 116 2 proteins protein NNS cord-337137-0ey40gzw 116 3 have have VBP cord-337137-0ey40gzw 116 4 relatively relatively RB cord-337137-0ey40gzw 116 5 higher high JJR cord-337137-0ey40gzw 116 6 homologies homology NNS cord-337137-0ey40gzw 116 7 to to IN cord-337137-0ey40gzw 116 8 known know VBN cord-337137-0ey40gzw 116 9 coronaviruses coronaviruse NNS cord-337137-0ey40gzw 116 10 . . . cord-337137-0ey40gzw 117 1 The the DT cord-337137-0ey40gzw 117 2 remaining remain VBG cord-337137-0ey40gzw 117 3 12 12 CD cord-337137-0ey40gzw 117 4 ORFs orf NNS cord-337137-0ey40gzw 117 5 are be VBP cord-337137-0ey40gzw 117 6 squeezed squeeze VBN cord-337137-0ey40gzw 117 7 into into IN cord-337137-0ey40gzw 117 8 the the DT cord-337137-0ey40gzw 117 9 3 3 CD cord-337137-0ey40gzw 117 10 end end NN cord-337137-0ey40gzw 117 11 of of IN cord-337137-0ey40gzw 117 12 the the DT cord-337137-0ey40gzw 117 13 genome genome NN cord-337137-0ey40gzw 117 14 . . . cord-337137-0ey40gzw 118 1 These these DT cord-337137-0ey40gzw 118 2 ORFs orf NNS cord-337137-0ey40gzw 118 3 include include VBP cord-337137-0ey40gzw 118 4 four four CD cord-337137-0ey40gzw 118 5 genes gene NNS cord-337137-0ey40gzw 118 6 encoding encode VBG cord-337137-0ey40gzw 118 7 known know VBN cord-337137-0ey40gzw 118 8 structural structural JJ cord-337137-0ey40gzw 118 9 proteins protein NNS cord-337137-0ey40gzw 118 10 ( ( -LRB- cord-337137-0ey40gzw 118 11 envelope envelope NN cord-337137-0ey40gzw 118 12 , , , cord-337137-0ey40gzw 118 13 membrane membrane NN cord-337137-0ey40gzw 118 14 , , , cord-337137-0ey40gzw 118 15 nucleocapsid nucleocapsid NN cord-337137-0ey40gzw 118 16 , , , cord-337137-0ey40gzw 118 17 and and CC cord-337137-0ey40gzw 118 18 spike spike NN cord-337137-0ey40gzw 118 19 proteins protein NNS cord-337137-0ey40gzw 118 20 , , , cord-337137-0ey40gzw 118 21 respectively respectively RB cord-337137-0ey40gzw 118 22 ) ) -RRB- cord-337137-0ey40gzw 118 23 . . . cord-337137-0ey40gzw 119 1 The the DT cord-337137-0ey40gzw 119 2 remaining remain VBG cord-337137-0ey40gzw 119 3 potential potential JJ cord-337137-0ey40gzw 119 4 ORFs orfs NN cord-337137-0ey40gzw 119 5 encode encode VB cord-337137-0ey40gzw 119 6 hypothetical hypothetical JJ cord-337137-0ey40gzw 119 7 SARS SARS NNP cord-337137-0ey40gzw 119 8 - - HYPH cord-337137-0ey40gzw 119 9 CoV cov NN cord-337137-0ey40gzw 119 10 - - HYPH cord-337137-0ey40gzw 119 11 specific specific JJ cord-337137-0ey40gzw 119 12 proteins protein NNS cord-337137-0ey40gzw 119 13 which which WDT cord-337137-0ey40gzw 119 14 lack lack VBP cord-337137-0ey40gzw 119 15 obvious obvious JJ cord-337137-0ey40gzw 119 16 sequence sequence NN cord-337137-0ey40gzw 119 17 similarity similarity NN cord-337137-0ey40gzw 119 18 to to IN cord-337137-0ey40gzw 119 19 known know VBN cord-337137-0ey40gzw 119 20 proteins protein NNS cord-337137-0ey40gzw 119 21 [ [ -LRB- cord-337137-0ey40gzw 119 22 62 62 CD cord-337137-0ey40gzw 119 23 , , , cord-337137-0ey40gzw 119 24 63 63 CD cord-337137-0ey40gzw 119 25 ] ] -RRB- cord-337137-0ey40gzw 119 26 . . . cord-337137-0ey40gzw 120 1 The the DT cord-337137-0ey40gzw 120 2 functions function NNS cord-337137-0ey40gzw 120 3 of of IN cord-337137-0ey40gzw 120 4 these these DT cord-337137-0ey40gzw 120 5 hypothetical hypothetical JJ cord-337137-0ey40gzw 120 6 proteins protein NNS cord-337137-0ey40gzw 120 7 and and CC cord-337137-0ey40gzw 120 8 their -PRON- PRP$ cord-337137-0ey40gzw 120 9 roles role NNS cord-337137-0ey40gzw 120 10 in in IN cord-337137-0ey40gzw 120 11 SARS SARS NNP cord-337137-0ey40gzw 120 12 pathogenesis pathogenesis NN cord-337137-0ey40gzw 120 13 remain remain VBP cord-337137-0ey40gzw 120 14 obscure obscure JJ cord-337137-0ey40gzw 120 15 [ [ -LRB- cord-337137-0ey40gzw 120 16 64 64 CD cord-337137-0ey40gzw 120 17 , , , cord-337137-0ey40gzw 120 18 65 65 CD cord-337137-0ey40gzw 120 19 ] ] -RRB- cord-337137-0ey40gzw 120 20 . . . cord-337137-0ey40gzw 121 1 Antibodies antibody NNS cord-337137-0ey40gzw 121 2 against against IN cord-337137-0ey40gzw 121 3 some some DT cord-337137-0ey40gzw 121 4 of of IN cord-337137-0ey40gzw 121 5 these these DT cord-337137-0ey40gzw 121 6 putative putative JJ cord-337137-0ey40gzw 121 7 proteins protein NNS cord-337137-0ey40gzw 121 8 , , , cord-337137-0ey40gzw 121 9 notably notably RB cord-337137-0ey40gzw 121 10 SARS3a sars3a JJ cord-337137-0ey40gzw 121 11 and and CC cord-337137-0ey40gzw 121 12 SARS6 sars6 NN cord-337137-0ey40gzw 121 13 , , , cord-337137-0ey40gzw 121 14 can can MD cord-337137-0ey40gzw 121 15 be be VB cord-337137-0ey40gzw 121 16 detected detect VBN cord-337137-0ey40gzw 121 17 in in IN cord-337137-0ey40gzw 121 18 the the DT cord-337137-0ey40gzw 121 19 serum serum NN cord-337137-0ey40gzw 121 20 of of IN cord-337137-0ey40gzw 121 21 SARS SARS NNP cord-337137-0ey40gzw 121 22 patients patient NNS cord-337137-0ey40gzw 121 23 [ [ -LRB- cord-337137-0ey40gzw 121 24 66 66 CD cord-337137-0ey40gzw 121 25 ] ] -RRB- cord-337137-0ey40gzw 121 26 . . . cord-337137-0ey40gzw 122 1 There there EX cord-337137-0ey40gzw 122 2 is be VBZ cord-337137-0ey40gzw 122 3 also also RB cord-337137-0ey40gzw 122 4 evidence evidence NN cord-337137-0ey40gzw 122 5 suggesting suggest VBG cord-337137-0ey40gzw 122 6 that that IN cord-337137-0ey40gzw 122 7 a a DT cord-337137-0ey40gzw 122 8 number number NN cord-337137-0ey40gzw 122 9 of of IN cord-337137-0ey40gzw 122 10 these these DT cord-337137-0ey40gzw 122 11 proteins protein NNS cord-337137-0ey40gzw 122 12 , , , cord-337137-0ey40gzw 122 13 including include VBG cord-337137-0ey40gzw 122 14 SARS3a SARS3a NNP cord-337137-0ey40gzw 122 15 , , , cord-337137-0ey40gzw 122 16 3b 3b CD cord-337137-0ey40gzw 122 17 , , , cord-337137-0ey40gzw 122 18 7a 7a NN cord-337137-0ey40gzw 122 19 , , , cord-337137-0ey40gzw 122 20 and and CC cord-337137-0ey40gzw 122 21 9b 9b NNS cord-337137-0ey40gzw 122 22 , , , cord-337137-0ey40gzw 122 23 were be VBD cord-337137-0ey40gzw 122 24 expressed express VBN cord-337137-0ey40gzw 122 25 in in IN cord-337137-0ey40gzw 122 26 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 122 27 and and CC cord-337137-0ey40gzw 122 28 enterocytes enterocytes NNPS cord-337137-0ey40gzw 122 29 in in IN cord-337137-0ey40gzw 122 30 deceased deceased JJ cord-337137-0ey40gzw 122 31 patients patient NNS cord-337137-0ey40gzw 122 32 [ [ -LRB- cord-337137-0ey40gzw 122 33 23 23 CD cord-337137-0ey40gzw 122 34 ] ] -RRB- cord-337137-0ey40gzw 122 35 . . . cord-337137-0ey40gzw 123 1 However however RB cord-337137-0ey40gzw 123 2 , , , cord-337137-0ey40gzw 123 3 differential differential JJ cord-337137-0ey40gzw 123 4 expression expression NN cord-337137-0ey40gzw 123 5 patterns pattern NNS cord-337137-0ey40gzw 123 6 of of IN cord-337137-0ey40gzw 123 7 these these DT cord-337137-0ey40gzw 123 8 proteins protein NNS cord-337137-0ey40gzw 123 9 in in IN cord-337137-0ey40gzw 123 10 cell cell NN cord-337137-0ey40gzw 123 11 types type NNS cord-337137-0ey40gzw 123 12 showing show VBG cord-337137-0ey40gzw 123 13 different different JJ cord-337137-0ey40gzw 123 14 responses response NNS cord-337137-0ey40gzw 123 15 to to IN cord-337137-0ey40gzw 123 16 SARS SARS NNP cord-337137-0ey40gzw 123 17 - - HYPH cord-337137-0ey40gzw 123 18 CoV CoV NNP cord-337137-0ey40gzw 123 19 infection infection NN cord-337137-0ey40gzw 123 20 have have VBP cord-337137-0ey40gzw 123 21 not not RB cord-337137-0ey40gzw 123 22 been be VBN cord-337137-0ey40gzw 123 23 confirmed confirm VBN cord-337137-0ey40gzw 123 24 . . . cord-337137-0ey40gzw 124 1 By by IN cord-337137-0ey40gzw 124 2 expressing express VBG cord-337137-0ey40gzw 124 3 the the DT cord-337137-0ey40gzw 124 4 hypothetical hypothetical JJ cord-337137-0ey40gzw 124 5 proteins protein NNS cord-337137-0ey40gzw 124 6 individually individually RB cord-337137-0ey40gzw 124 7 in in IN cord-337137-0ey40gzw 124 8 tissue tissue NN cord-337137-0ey40gzw 124 9 culture culture NN cord-337137-0ey40gzw 124 10 , , , cord-337137-0ey40gzw 124 11 we -PRON- PRP cord-337137-0ey40gzw 124 12 are be VBP cord-337137-0ey40gzw 124 13 beginning begin VBG cord-337137-0ey40gzw 124 14 to to TO cord-337137-0ey40gzw 124 15 see see VB cord-337137-0ey40gzw 124 16 data datum NNS cord-337137-0ey40gzw 124 17 on on IN cord-337137-0ey40gzw 124 18 the the DT cord-337137-0ey40gzw 124 19 cellular cellular JJ cord-337137-0ey40gzw 124 20 functions function NNS cord-337137-0ey40gzw 124 21 of of IN cord-337137-0ey40gzw 124 22 these these DT cord-337137-0ey40gzw 124 23 proteins protein NNS cord-337137-0ey40gzw 124 24 . . . cord-337137-0ey40gzw 125 1 SARS3a SARS3a NNP cord-337137-0ey40gzw 125 2 appears appear VBZ cord-337137-0ey40gzw 125 3 to to TO cord-337137-0ey40gzw 125 4 be be VB cord-337137-0ey40gzw 125 5 important important JJ cord-337137-0ey40gzw 125 6 in in IN cord-337137-0ey40gzw 125 7 mediating mediate VBG cord-337137-0ey40gzw 125 8 apoptosis apoptosis NN cord-337137-0ey40gzw 125 9 in in IN cord-337137-0ey40gzw 125 10 some some DT cord-337137-0ey40gzw 125 11 cell cell NN cord-337137-0ey40gzw 125 12 types type NNS cord-337137-0ey40gzw 125 13 [ [ -LRB- cord-337137-0ey40gzw 125 14 67 67 CD cord-337137-0ey40gzw 125 15 ] ] -RRB- cord-337137-0ey40gzw 125 16 . . . cord-337137-0ey40gzw 126 1 The the DT cord-337137-0ey40gzw 126 2 SARS3a SARS3a NNP cord-337137-0ey40gzw 126 3 protein protein NN cord-337137-0ey40gzw 126 4 is be VBZ cord-337137-0ey40gzw 126 5 incorporated incorporate VBN cord-337137-0ey40gzw 126 6 into into IN cord-337137-0ey40gzw 126 7 the the DT cord-337137-0ey40gzw 126 8 viron viron JJ cord-337137-0ey40gzw 126 9 particle particle NN cord-337137-0ey40gzw 126 10 and and CC cord-337137-0ey40gzw 126 11 may may MD cord-337137-0ey40gzw 126 12 also also RB cord-337137-0ey40gzw 126 13 act act VB cord-337137-0ey40gzw 126 14 as as IN cord-337137-0ey40gzw 126 15 one one CD cord-337137-0ey40gzw 126 16 of of IN cord-337137-0ey40gzw 126 17 the the DT cord-337137-0ey40gzw 126 18 structural structural JJ cord-337137-0ey40gzw 126 19 proteins protein NNS cord-337137-0ey40gzw 126 20 [ [ -LRB- cord-337137-0ey40gzw 126 21 68 68 CD cord-337137-0ey40gzw 126 22 ] ] -RRB- cord-337137-0ey40gzw 126 23 [ [ -LRB- cord-337137-0ey40gzw 126 24 69 69 CD cord-337137-0ey40gzw 126 25 ] ] -RRB- cord-337137-0ey40gzw 126 26 [ [ -LRB- cord-337137-0ey40gzw 126 27 70 70 CD cord-337137-0ey40gzw 126 28 ] ] -RRB- cord-337137-0ey40gzw 126 29 . . . cord-337137-0ey40gzw 127 1 Through through IN cord-337137-0ey40gzw 127 2 an an DT cord-337137-0ey40gzw 127 3 unknown unknown JJ cord-337137-0ey40gzw 127 4 mechanism mechanism NN cord-337137-0ey40gzw 127 5 , , , cord-337137-0ey40gzw 127 6 host host NN cord-337137-0ey40gzw 127 7 cells cell NNS cord-337137-0ey40gzw 127 8 overexpressing overexpresse VBG cord-337137-0ey40gzw 127 9 SARS3a SARS3a NNP cord-337137-0ey40gzw 127 10 have have VBP cord-337137-0ey40gzw 127 11 increased increase VBN cord-337137-0ey40gzw 127 12 expression expression NN cord-337137-0ey40gzw 127 13 of of IN cord-337137-0ey40gzw 127 14 fibrinogen fibrinogen NN cord-337137-0ey40gzw 127 15 mRNA mrna NN cord-337137-0ey40gzw 127 16 [ [ -LRB- cord-337137-0ey40gzw 127 17 71 71 CD cord-337137-0ey40gzw 127 18 ] ] -RRB- cord-337137-0ey40gzw 127 19 . . . cord-337137-0ey40gzw 128 1 SARS7a SARS7a NNP cord-337137-0ey40gzw 128 2 has have VBZ cord-337137-0ey40gzw 128 3 been be VBN cord-337137-0ey40gzw 128 4 implied imply VBN cord-337137-0ey40gzw 128 5 in in IN cord-337137-0ey40gzw 128 6 mediating mediate VBG cord-337137-0ey40gzw 128 7 apoptosis apoptosis NN cord-337137-0ey40gzw 128 8 through through IN cord-337137-0ey40gzw 128 9 the the DT cord-337137-0ey40gzw 128 10 caspase caspase NN cord-337137-0ey40gzw 128 11 - - HYPH cord-337137-0ey40gzw 128 12 dependent dependent JJ cord-337137-0ey40gzw 128 13 pathways pathway NNS cord-337137-0ey40gzw 128 14 [ [ -LRB- cord-337137-0ey40gzw 128 15 72 72 CD cord-337137-0ey40gzw 128 16 ] ] -RRB- cord-337137-0ey40gzw 128 17 . . . cord-337137-0ey40gzw 129 1 The the DT cord-337137-0ey40gzw 129 2 effect effect NN cord-337137-0ey40gzw 129 3 of of IN cord-337137-0ey40gzw 129 4 SARS SARS NNP cord-337137-0ey40gzw 129 5 - - HYPH cord-337137-0ey40gzw 129 6 CoV CoV NNP cord-337137-0ey40gzw 129 7 infection infection NN cord-337137-0ey40gzw 129 8 varies vary VBZ cord-337137-0ey40gzw 129 9 in in IN cord-337137-0ey40gzw 129 10 different different JJ cord-337137-0ey40gzw 129 11 cell cell NN cord-337137-0ey40gzw 129 12 types type NNS cord-337137-0ey40gzw 129 13 . . . cord-337137-0ey40gzw 130 1 Apoptosis apoptosis NN cord-337137-0ey40gzw 130 2 and and CC cord-337137-0ey40gzw 130 3 syncytial syncytial JJ cord-337137-0ey40gzw 130 4 formation formation NN cord-337137-0ey40gzw 130 5 are be VBP cord-337137-0ey40gzw 130 6 seen see VBN cord-337137-0ey40gzw 130 7 in in IN cord-337137-0ey40gzw 130 8 infected infected JJ cord-337137-0ey40gzw 130 9 monkey monkey NN cord-337137-0ey40gzw 130 10 renal renal JJ cord-337137-0ey40gzw 130 11 epithelial epithelial JJ cord-337137-0ey40gzw 130 12 cells cell NNS cord-337137-0ey40gzw 130 13 ( ( -LRB- cord-337137-0ey40gzw 130 14 Vero Vero NNP cord-337137-0ey40gzw 130 15 E6 E6 NNP cord-337137-0ey40gzw 130 16 ) ) -RRB- cord-337137-0ey40gzw 130 17 [ [ -LRB- cord-337137-0ey40gzw 130 18 67 67 CD cord-337137-0ey40gzw 130 19 ] ] -RRB- cord-337137-0ey40gzw 130 20 . . . cord-337137-0ey40gzw 131 1 Persistent persistent JJ cord-337137-0ey40gzw 131 2 infection infection NN cord-337137-0ey40gzw 131 3 with with IN cord-337137-0ey40gzw 131 4 no no DT cord-337137-0ey40gzw 131 5 change change NN cord-337137-0ey40gzw 131 6 in in IN cord-337137-0ey40gzw 131 7 cellular cellular JJ cord-337137-0ey40gzw 131 8 morphology morphology NN cord-337137-0ey40gzw 131 9 or or CC cord-337137-0ey40gzw 131 10 doubling double VBG cord-337137-0ey40gzw 131 11 time time NN cord-337137-0ey40gzw 131 12 was be VBD cord-337137-0ey40gzw 131 13 detected detect VBN cord-337137-0ey40gzw 131 14 in in IN cord-337137-0ey40gzw 131 15 the the DT cord-337137-0ey40gzw 131 16 colon colon NN cord-337137-0ey40gzw 131 17 cancer cancer NN cord-337137-0ey40gzw 131 18 cell cell NN cord-337137-0ey40gzw 131 19 line line NN cord-337137-0ey40gzw 131 20 LoVo LoVo NNP cord-337137-0ey40gzw 131 21 [ [ -LRB- cord-337137-0ey40gzw 131 22 46 46 CD cord-337137-0ey40gzw 131 23 ] ] -RRB- cord-337137-0ey40gzw 131 24 . . . cord-337137-0ey40gzw 132 1 In in IN cord-337137-0ey40gzw 132 2 clinical clinical JJ cord-337137-0ey40gzw 132 3 specimens specimen NNS cord-337137-0ey40gzw 132 4 , , , cord-337137-0ey40gzw 132 5 SARS SARS NNP cord-337137-0ey40gzw 132 6 - - HYPH cord-337137-0ey40gzw 132 7 CoV CoV NNP cord-337137-0ey40gzw 132 8 was be VBD cord-337137-0ey40gzw 132 9 detected detect VBN cord-337137-0ey40gzw 132 10 in in IN cord-337137-0ey40gzw 132 11 the the DT cord-337137-0ey40gzw 132 12 lungs lung NNS cord-337137-0ey40gzw 132 13 and and CC cord-337137-0ey40gzw 132 14 small small JJ cord-337137-0ey40gzw 132 15 intestine intestine NN cord-337137-0ey40gzw 132 16 . . . cord-337137-0ey40gzw 133 1 Severe severe JJ cord-337137-0ey40gzw 133 2 cellular cellular JJ cord-337137-0ey40gzw 133 3 damage damage NN cord-337137-0ey40gzw 133 4 is be VBZ cord-337137-0ey40gzw 133 5 characteristically characteristically RB cord-337137-0ey40gzw 133 6 detected detect VBN cord-337137-0ey40gzw 133 7 in in IN cord-337137-0ey40gzw 133 8 the the DT cord-337137-0ey40gzw 133 9 lungs lung NNS cord-337137-0ey40gzw 133 10 of of IN cord-337137-0ey40gzw 133 11 SARS SARS NNP cord-337137-0ey40gzw 133 12 patients patient NNS cord-337137-0ey40gzw 133 13 , , , cord-337137-0ey40gzw 133 14 while while IN cord-337137-0ey40gzw 133 15 no no DT cord-337137-0ey40gzw 133 16 morphological morphological JJ cord-337137-0ey40gzw 133 17 changes change NNS cord-337137-0ey40gzw 133 18 are be VBP cord-337137-0ey40gzw 133 19 observed observe VBN cord-337137-0ey40gzw 133 20 in in IN cord-337137-0ey40gzw 133 21 the the DT cord-337137-0ey40gzw 133 22 small small JJ cord-337137-0ey40gzw 133 23 intestine intestine NN cord-337137-0ey40gzw 133 24 . . . cord-337137-0ey40gzw 134 1 The the DT cord-337137-0ey40gzw 134 2 basis basis NN cord-337137-0ey40gzw 134 3 of of IN cord-337137-0ey40gzw 134 4 these these DT cord-337137-0ey40gzw 134 5 differences difference NNS cord-337137-0ey40gzw 134 6 in in IN cord-337137-0ey40gzw 134 7 cellular cellular JJ cord-337137-0ey40gzw 134 8 responses response NNS cord-337137-0ey40gzw 134 9 is be VBZ cord-337137-0ey40gzw 134 10 not not RB cord-337137-0ey40gzw 134 11 clear clear JJ cord-337137-0ey40gzw 134 12 . . . cord-337137-0ey40gzw 135 1 The the DT cord-337137-0ey40gzw 135 2 tissue tissue NN cord-337137-0ey40gzw 135 3 / / SYM cord-337137-0ey40gzw 135 4 cellular cellular JJ cord-337137-0ey40gzw 135 5 tropism tropism NN cord-337137-0ey40gzw 135 6 may may MD cord-337137-0ey40gzw 135 7 be be VB cord-337137-0ey40gzw 135 8 partly partly RB cord-337137-0ey40gzw 135 9 related relate VBN cord-337137-0ey40gzw 135 10 to to IN cord-337137-0ey40gzw 135 11 differential differential JJ cord-337137-0ey40gzw 135 12 expression expression NN cord-337137-0ey40gzw 135 13 of of IN cord-337137-0ey40gzw 135 14 membrane membrane NN cord-337137-0ey40gzw 135 15 receptors receptor NNS cord-337137-0ey40gzw 135 16 for for IN cord-337137-0ey40gzw 135 17 the the DT cord-337137-0ey40gzw 135 18 SARS SARS NNP cord-337137-0ey40gzw 135 19 - - HYPH cord-337137-0ey40gzw 135 20 CoV CoV NNP cord-337137-0ey40gzw 135 21 [ [ -LRB- cord-337137-0ey40gzw 135 22 22 22 CD cord-337137-0ey40gzw 135 23 ] ] -RRB- cord-337137-0ey40gzw 135 24 . . . cord-337137-0ey40gzw 136 1 These these DT cord-337137-0ey40gzw 136 2 observations observation NNS cord-337137-0ey40gzw 136 3 highlight highlight VBP cord-337137-0ey40gzw 136 4 the the DT cord-337137-0ey40gzw 136 5 importance importance NN cord-337137-0ey40gzw 136 6 of of IN cord-337137-0ey40gzw 136 7 host host NN cord-337137-0ey40gzw 136 8 cell cell NN cord-337137-0ey40gzw 136 9 responses response NNS cord-337137-0ey40gzw 136 10 in in IN cord-337137-0ey40gzw 136 11 SARS SARS NNP cord-337137-0ey40gzw 136 12 - - HYPH cord-337137-0ey40gzw 136 13 CoV CoV NNP cord-337137-0ey40gzw 136 14 infection infection NN cord-337137-0ey40gzw 136 15 . . . cord-337137-0ey40gzw 137 1 It -PRON- PRP cord-337137-0ey40gzw 137 2 is be VBZ cord-337137-0ey40gzw 137 3 also also RB cord-337137-0ey40gzw 137 4 clear clear JJ cord-337137-0ey40gzw 137 5 from from IN cord-337137-0ey40gzw 137 6 these these DT cord-337137-0ey40gzw 137 7 observations observation NNS cord-337137-0ey40gzw 137 8 that that WDT cord-337137-0ey40gzw 137 9 cytopathic cytopathic JJ cord-337137-0ey40gzw 137 10 damage damage NN cord-337137-0ey40gzw 137 11 alone alone RB cord-337137-0ey40gzw 137 12 can can MD cord-337137-0ey40gzw 137 13 not not RB cord-337137-0ey40gzw 137 14 explain explain VB cord-337137-0ey40gzw 137 15 the the DT cord-337137-0ey40gzw 137 16 pathogenesis pathogenesis NN cord-337137-0ey40gzw 137 17 of of IN cord-337137-0ey40gzw 137 18 SARS SARS NNP cord-337137-0ey40gzw 137 19 . . . cord-337137-0ey40gzw 138 1 The the DT cord-337137-0ey40gzw 138 2 marked marked JJ cord-337137-0ey40gzw 138 3 heterogeneity heterogeneity NN cord-337137-0ey40gzw 138 4 of of IN cord-337137-0ey40gzw 138 5 the the DT cord-337137-0ey40gzw 138 6 disease disease NN cord-337137-0ey40gzw 138 7 course course NN cord-337137-0ey40gzw 138 8 and and CC cord-337137-0ey40gzw 138 9 outcome outcome NN cord-337137-0ey40gzw 138 10 after after IN cord-337137-0ey40gzw 138 11 SARS SARS NNP cord-337137-0ey40gzw 138 12 infection infection NN cord-337137-0ey40gzw 138 13 suggests suggest VBZ cord-337137-0ey40gzw 138 14 that that IN cord-337137-0ey40gzw 138 15 host host NN cord-337137-0ey40gzw 138 16 responses response NNS cord-337137-0ey40gzw 138 17 may may MD cord-337137-0ey40gzw 138 18 play play VB cord-337137-0ey40gzw 138 19 an an DT cord-337137-0ey40gzw 138 20 important important JJ cord-337137-0ey40gzw 138 21 role role NN cord-337137-0ey40gzw 138 22 in in IN cord-337137-0ey40gzw 138 23 pathogenesis pathogenesis NN cord-337137-0ey40gzw 138 24 . . . cord-337137-0ey40gzw 139 1 DAD DAD NNP cord-337137-0ey40gzw 139 2 or or CC cord-337137-0ey40gzw 139 3 ARDS ARDS NNP cord-337137-0ey40gzw 139 4 appears appear VBZ cord-337137-0ey40gzw 139 5 to to TO cord-337137-0ey40gzw 139 6 be be VB cord-337137-0ey40gzw 139 7 a a DT cord-337137-0ey40gzw 139 8 common common JJ cord-337137-0ey40gzw 139 9 pathway pathway NN cord-337137-0ey40gzw 139 10 of of IN cord-337137-0ey40gzw 139 11 lung lung NN cord-337137-0ey40gzw 139 12 parenchyma parenchyma NN cord-337137-0ey40gzw 139 13 damage damage NN cord-337137-0ey40gzw 139 14 initiated initiate VBN cord-337137-0ey40gzw 139 15 by by IN cord-337137-0ey40gzw 139 16 a a DT cord-337137-0ey40gzw 139 17 variety variety NN cord-337137-0ey40gzw 139 18 of of IN cord-337137-0ey40gzw 139 19 aetiologies aetiology NNS cord-337137-0ey40gzw 139 20 , , , cord-337137-0ey40gzw 139 21 including include VBG cord-337137-0ey40gzw 139 22 SARS SARS NNP cord-337137-0ey40gzw 139 23 - - HYPH cord-337137-0ey40gzw 139 24 CoV CoV NNP cord-337137-0ey40gzw 139 25 infection infection NN cord-337137-0ey40gzw 139 26 itself -PRON- PRP cord-337137-0ey40gzw 139 27 , , , cord-337137-0ey40gzw 139 28 systemic systemic JJ cord-337137-0ey40gzw 139 29 sepsis sepsis NN cord-337137-0ey40gzw 139 30 , , , cord-337137-0ey40gzw 139 31 shock shock NN cord-337137-0ey40gzw 139 32 , , , cord-337137-0ey40gzw 139 33 and and CC cord-337137-0ey40gzw 139 34 direct direct JJ cord-337137-0ey40gzw 139 35 lung lung NN cord-337137-0ey40gzw 139 36 contusion contusion NN cord-337137-0ey40gzw 139 37 . . . cord-337137-0ey40gzw 140 1 Once once IN cord-337137-0ey40gzw 140 2 an an DT cord-337137-0ey40gzw 140 3 inflammatory inflammatory JJ cord-337137-0ey40gzw 140 4 process process NN cord-337137-0ey40gzw 140 5 reaches reach VBZ cord-337137-0ey40gzw 140 6 a a DT cord-337137-0ey40gzw 140 7 certain certain JJ cord-337137-0ey40gzw 140 8 intensity intensity NN cord-337137-0ey40gzw 140 9 , , , cord-337137-0ey40gzw 140 10 it -PRON- PRP cord-337137-0ey40gzw 140 11 may may MD cord-337137-0ey40gzw 140 12 self self NN cord-337137-0ey40gzw 140 13 - - HYPH cord-337137-0ey40gzw 140 14 perpetuate perpetuate VB cord-337137-0ey40gzw 140 15 . . . cord-337137-0ey40gzw 141 1 The the DT cord-337137-0ey40gzw 141 2 cellular cellular JJ cord-337137-0ey40gzw 141 3 inflammatory inflammatory JJ cord-337137-0ey40gzw 141 4 infiltrate infiltrate NN cord-337137-0ey40gzw 141 5 releases release VBZ cord-337137-0ey40gzw 141 6 toxic toxic JJ cord-337137-0ey40gzw 141 7 metabolites metabolite NNS cord-337137-0ey40gzw 141 8 and and CC cord-337137-0ey40gzw 141 9 proteolytic proteolytic JJ cord-337137-0ey40gzw 141 10 enzymes enzyme NNS cord-337137-0ey40gzw 141 11 , , , cord-337137-0ey40gzw 141 12 which which WDT cord-337137-0ey40gzw 141 13 may may MD cord-337137-0ey40gzw 141 14 cause cause VB cord-337137-0ey40gzw 141 15 further further JJ cord-337137-0ey40gzw 141 16 damage damage NN cord-337137-0ey40gzw 141 17 to to IN cord-337137-0ey40gzw 141 18 the the DT cord-337137-0ey40gzw 141 19 lung lung NN cord-337137-0ey40gzw 141 20 parenchyma parenchyma NN cord-337137-0ey40gzw 141 21 . . . cord-337137-0ey40gzw 142 1 The the DT cord-337137-0ey40gzw 142 2 surrounding surround VBG cord-337137-0ey40gzw 142 3 inflamed inflamed JJ cord-337137-0ey40gzw 142 4 capillaries capillary NNS cord-337137-0ey40gzw 142 5 launch launch VBP cord-337137-0ey40gzw 142 6 the the DT cord-337137-0ey40gzw 142 7 coagulation coagulation NN cord-337137-0ey40gzw 142 8 cascade cascade NN cord-337137-0ey40gzw 142 9 and and CC cord-337137-0ey40gzw 142 10 recruit recruit VBP cord-337137-0ey40gzw 142 11 more more JJR cord-337137-0ey40gzw 142 12 immune immune JJ cord-337137-0ey40gzw 142 13 cells cell NNS cord-337137-0ey40gzw 142 14 [ [ -LRB- cord-337137-0ey40gzw 142 15 73 73 CD cord-337137-0ey40gzw 142 16 , , , cord-337137-0ey40gzw 142 17 74 74 CD cord-337137-0ey40gzw 142 18 ] ] -RRB- cord-337137-0ey40gzw 142 19 . . . cord-337137-0ey40gzw 143 1 Our -PRON- PRP$ cord-337137-0ey40gzw 143 2 previous previous JJ cord-337137-0ey40gzw 143 3 investigation investigation NN cord-337137-0ey40gzw 143 4 in in IN cord-337137-0ey40gzw 143 5 the the DT cord-337137-0ey40gzw 143 6 1997 1997 CD cord-337137-0ey40gzw 143 7 H5N1 H5N1 NNP cord-337137-0ey40gzw 143 8 influenza influenza NN cord-337137-0ey40gzw 143 9 outbreak outbreak NN cord-337137-0ey40gzw 143 10 showed show VBD cord-337137-0ey40gzw 143 11 that that IN cord-337137-0ey40gzw 143 12 patients patient NNS cord-337137-0ey40gzw 143 13 who who WP cord-337137-0ey40gzw 143 14 died die VBD cord-337137-0ey40gzw 143 15 of of IN cord-337137-0ey40gzw 143 16 the the DT cord-337137-0ey40gzw 143 17 disease disease NN cord-337137-0ey40gzw 143 18 had have VBD cord-337137-0ey40gzw 143 19 lymphoid lymphoid JJ cord-337137-0ey40gzw 143 20 depletion depletion NN cord-337137-0ey40gzw 143 21 associated associate VBN cord-337137-0ey40gzw 143 22 with with IN cord-337137-0ey40gzw 143 23 marked marked JJ cord-337137-0ey40gzw 143 24 elevation elevation NN cord-337137-0ey40gzw 143 25 of of IN cord-337137-0ey40gzw 143 26 circulating circulate VBG cord-337137-0ey40gzw 143 27 concentrations concentration NNS cord-337137-0ey40gzw 143 28 of of IN cord-337137-0ey40gzw 143 29 cytokines cytokine NNS cord-337137-0ey40gzw 143 30 , , , cord-337137-0ey40gzw 143 31 including include VBG cord-337137-0ey40gzw 143 32 interleukin-6 interleukin-6 NNP cord-337137-0ey40gzw 143 33 ( ( -LRB- cord-337137-0ey40gzw 143 34 IL-6 IL-6 NNP cord-337137-0ey40gzw 143 35 ) ) -RRB- cord-337137-0ey40gzw 143 36 , , , cord-337137-0ey40gzw 143 37 IL-2 IL-2 NNP cord-337137-0ey40gzw 143 38 receptor receptor NN cord-337137-0ey40gzw 143 39 , , , cord-337137-0ey40gzw 143 40 and and CC cord-337137-0ey40gzw 143 41 interferongamma interferongamma NNP cord-337137-0ey40gzw 143 42 [ [ -LRB- cord-337137-0ey40gzw 143 43 75 75 CD cord-337137-0ey40gzw 143 44 ] ] -RRB- cord-337137-0ey40gzw 143 45 . . . cord-337137-0ey40gzw 144 1 With with IN cord-337137-0ey40gzw 144 2 the the DT cord-337137-0ey40gzw 144 3 observation observation NN cord-337137-0ey40gzw 144 4 of of IN cord-337137-0ey40gzw 144 5 characteristic characteristic JJ cord-337137-0ey40gzw 144 6 lymphopenia lymphopenia NNP cord-337137-0ey40gzw 144 7 in in IN cord-337137-0ey40gzw 144 8 SARS SARS NNP cord-337137-0ey40gzw 144 9 , , , cord-337137-0ey40gzw 144 10 it -PRON- PRP cord-337137-0ey40gzw 144 11 has have VBZ cord-337137-0ey40gzw 144 12 been be VBN cord-337137-0ey40gzw 144 13 postulated postulate VBN cord-337137-0ey40gzw 144 14 that that IN cord-337137-0ey40gzw 144 15 the the DT cord-337137-0ey40gzw 144 16 SARS SARS NNP cord-337137-0ey40gzw 144 17 - - HYPH cord-337137-0ey40gzw 144 18 CoV CoV NNP cord-337137-0ey40gzw 144 19 may may MD cord-337137-0ey40gzw 144 20 similarly similarly RB cord-337137-0ey40gzw 144 21 trigger trigger VB cord-337137-0ey40gzw 144 22 an an DT cord-337137-0ey40gzw 144 23 exaggerated exaggerated JJ cord-337137-0ey40gzw 144 24 hyper hyper JJ cord-337137-0ey40gzw 144 25 - - JJ cord-337137-0ey40gzw 144 26 cytokinemic cytokinemic JJ cord-337137-0ey40gzw 144 27 response response NN cord-337137-0ey40gzw 144 28 in in IN cord-337137-0ey40gzw 144 29 patients patient NNS cord-337137-0ey40gzw 144 30 with with IN cord-337137-0ey40gzw 144 31 DAD DAD NNP cord-337137-0ey40gzw 144 32 after after IN cord-337137-0ey40gzw 144 33 viral viral JJ cord-337137-0ey40gzw 144 34 infection infection NN cord-337137-0ey40gzw 144 35 [ [ -LRB- cord-337137-0ey40gzw 144 36 20 20 CD cord-337137-0ey40gzw 144 37 ] ] -RRB- cord-337137-0ey40gzw 144 38 . . . cord-337137-0ey40gzw 145 1 Current current JJ cord-337137-0ey40gzw 145 2 understanding understanding NN cord-337137-0ey40gzw 145 3 indicates indicate VBZ cord-337137-0ey40gzw 145 4 that that IN cord-337137-0ey40gzw 145 5 patients patient NNS cord-337137-0ey40gzw 145 6 with with IN cord-337137-0ey40gzw 145 7 a a DT cord-337137-0ey40gzw 145 8 more more RBR cord-337137-0ey40gzw 145 9 intense intense JJ cord-337137-0ey40gzw 145 10 immune immune JJ cord-337137-0ey40gzw 145 11 response response NN cord-337137-0ey40gzw 145 12 are be VBP cord-337137-0ey40gzw 145 13 those those DT cord-337137-0ey40gzw 145 14 at at IN cord-337137-0ey40gzw 145 15 risk risk NN cord-337137-0ey40gzw 145 16 of of IN cord-337137-0ey40gzw 145 17 a a DT cord-337137-0ey40gzw 145 18 poor poor JJ cord-337137-0ey40gzw 145 19 outcome outcome NN cord-337137-0ey40gzw 145 20 , , , cord-337137-0ey40gzw 145 21 as as IN cord-337137-0ey40gzw 145 22 the the DT cord-337137-0ey40gzw 145 23 immune immune JJ cord-337137-0ey40gzw 145 24 system system NN cord-337137-0ey40gzw 145 25 also also RB cord-337137-0ey40gzw 145 26 mounts mount VBZ cord-337137-0ey40gzw 145 27 a a DT cord-337137-0ey40gzw 145 28 profound profound JJ cord-337137-0ey40gzw 145 29 reaction reaction NN cord-337137-0ey40gzw 145 30 to to IN cord-337137-0ey40gzw 145 31 the the DT cord-337137-0ey40gzw 145 32 bystander bystander NN cord-337137-0ey40gzw 145 33 , , , cord-337137-0ey40gzw 145 34 the the DT cord-337137-0ey40gzw 145 35 lung lung NN cord-337137-0ey40gzw 145 36 parenchyma parenchyma NN cord-337137-0ey40gzw 145 37 , , , cord-337137-0ey40gzw 145 38 and and CC cord-337137-0ey40gzw 145 39 causes cause VBZ cord-337137-0ey40gzw 145 40 DAD DAD NNP cord-337137-0ey40gzw 145 41 [ [ -LRB- cord-337137-0ey40gzw 145 42 76 76 CD cord-337137-0ey40gzw 145 43 ] ] -RRB- cord-337137-0ey40gzw 145 44 . . . cord-337137-0ey40gzw 146 1 SARS SARS NNP cord-337137-0ey40gzw 146 2 patients patient NNS cord-337137-0ey40gzw 146 3 have have VBP cord-337137-0ey40gzw 146 4 variable variable JJ cord-337137-0ey40gzw 146 5 humoral humoral JJ cord-337137-0ey40gzw 146 6 responses response NNS cord-337137-0ey40gzw 146 7 to to IN cord-337137-0ey40gzw 146 8 individual individual JJ cord-337137-0ey40gzw 146 9 epitopes epitope NNS cord-337137-0ey40gzw 146 10 [ [ -LRB- cord-337137-0ey40gzw 146 11 66 66 CD cord-337137-0ey40gzw 146 12 ] ] -RRB- cord-337137-0ey40gzw 146 13 . . . cord-337137-0ey40gzw 147 1 However however RB cord-337137-0ey40gzw 147 2 , , , cord-337137-0ey40gzw 147 3 early early JJ cord-337137-0ey40gzw 147 4 sero sero NN cord-337137-0ey40gzw 147 5 - - HYPH cord-337137-0ey40gzw 147 6 conversion conversion NN cord-337137-0ey40gzw 147 7 and and CC cord-337137-0ey40gzw 147 8 high high JJ cord-337137-0ey40gzw 147 9 peak peak NN cord-337137-0ey40gzw 147 10 total total JJ cord-337137-0ey40gzw 147 11 SARS SARS NNP cord-337137-0ey40gzw 147 12 - - HYPH cord-337137-0ey40gzw 147 13 CoV CoV NNP cord-337137-0ey40gzw 147 14 IgG igg NN cord-337137-0ey40gzw 147 15 levels level NNS cord-337137-0ey40gzw 147 16 were be VBD cord-337137-0ey40gzw 147 17 associated associate VBN cord-337137-0ey40gzw 147 18 with with IN cord-337137-0ey40gzw 147 19 more more RBR cord-337137-0ey40gzw 147 20 severe severe JJ cord-337137-0ey40gzw 147 21 disease disease NN cord-337137-0ey40gzw 147 22 in in IN cord-337137-0ey40gzw 147 23 a a DT cord-337137-0ey40gzw 147 24 cohort cohort NN cord-337137-0ey40gzw 147 25 of of IN cord-337137-0ey40gzw 147 26 325 325 CD cord-337137-0ey40gzw 147 27 patients patient NNS cord-337137-0ey40gzw 147 28 [ [ -LRB- cord-337137-0ey40gzw 147 29 77 77 CD cord-337137-0ey40gzw 147 30 ] ] -RRB- cord-337137-0ey40gzw 147 31 . . . cord-337137-0ey40gzw 148 1 Hence hence RB cord-337137-0ey40gzw 148 2 , , , cord-337137-0ey40gzw 148 3 particularly particularly RB cord-337137-0ey40gzw 148 4 strong strong JJ cord-337137-0ey40gzw 148 5 humoral humoral JJ cord-337137-0ey40gzw 148 6 responses response NNS cord-337137-0ey40gzw 148 7 to to IN cord-337137-0ey40gzw 148 8 SARS SARS NNP cord-337137-0ey40gzw 148 9 - - HYPH cord-337137-0ey40gzw 148 10 CoV CoV NNP cord-337137-0ey40gzw 148 11 infection infection NN cord-337137-0ey40gzw 148 12 might may MD cord-337137-0ey40gzw 148 13 not not RB cord-337137-0ey40gzw 148 14 be be VB cord-337137-0ey40gzw 148 15 protective protective JJ cord-337137-0ey40gzw 148 16 but but CC cord-337137-0ey40gzw 148 17 , , , cord-337137-0ey40gzw 148 18 perhaps perhaps RB cord-337137-0ey40gzw 148 19 , , , cord-337137-0ey40gzw 148 20 might may MD cord-337137-0ey40gzw 148 21 be be VB cord-337137-0ey40gzw 148 22 harmful harmful JJ cord-337137-0ey40gzw 148 23 to to IN cord-337137-0ey40gzw 148 24 the the DT cord-337137-0ey40gzw 148 25 host host NN cord-337137-0ey40gzw 148 26 . . . cord-337137-0ey40gzw 149 1 The the DT cord-337137-0ey40gzw 149 2 specific specific JJ cord-337137-0ey40gzw 149 3 epitopes epitope NNS cord-337137-0ey40gzw 149 4 upon upon IN cord-337137-0ey40gzw 149 5 which which WDT cord-337137-0ey40gzw 149 6 these these DT cord-337137-0ey40gzw 149 7 ' ' `` cord-337137-0ey40gzw 149 8 damaging damaging JJ cord-337137-0ey40gzw 149 9 ' ' '' cord-337137-0ey40gzw 149 10 antibodies antibody NNS cord-337137-0ey40gzw 149 11 act act NN cord-337137-0ey40gzw 149 12 await await VBP cord-337137-0ey40gzw 149 13 further further JJ cord-337137-0ey40gzw 149 14 characterization characterization NN cord-337137-0ey40gzw 149 15 . . . cord-337137-0ey40gzw 150 1 There there EX cord-337137-0ey40gzw 150 2 is be VBZ cord-337137-0ey40gzw 150 3 evidence evidence NN cord-337137-0ey40gzw 150 4 that that IN cord-337137-0ey40gzw 150 5 disarray disarray NN cord-337137-0ey40gzw 150 6 of of IN cord-337137-0ey40gzw 150 7 the the DT cord-337137-0ey40gzw 150 8 immune immune JJ cord-337137-0ey40gzw 150 9 system system NN cord-337137-0ey40gzw 150 10 towards towards IN cord-337137-0ey40gzw 150 11 the the DT cord-337137-0ey40gzw 150 12 host host NN cord-337137-0ey40gzw 150 13 's 's POS cord-337137-0ey40gzw 150 14 own own JJ cord-337137-0ey40gzw 150 15 antigens antigen NNS cord-337137-0ey40gzw 150 16 may may MD cord-337137-0ey40gzw 150 17 play play VB cord-337137-0ey40gzw 150 18 a a DT cord-337137-0ey40gzw 150 19 role role NN cord-337137-0ey40gzw 150 20 in in IN cord-337137-0ey40gzw 150 21 the the DT cord-337137-0ey40gzw 150 22 pathology pathology NN cord-337137-0ey40gzw 150 23 of of IN cord-337137-0ey40gzw 150 24 SARS SARS NNP cord-337137-0ey40gzw 150 25 . . . cord-337137-0ey40gzw 151 1 In in IN cord-337137-0ey40gzw 151 2 the the DT cord-337137-0ey40gzw 151 3 early early JJ cord-337137-0ey40gzw 151 4 phase phase NN cord-337137-0ey40gzw 151 5 , , , cord-337137-0ey40gzw 151 6 within within IN cord-337137-0ey40gzw 151 7 1 1 CD cord-337137-0ey40gzw 151 8 week week NN cord-337137-0ey40gzw 151 9 of of IN cord-337137-0ey40gzw 151 10 SARS SARS NNP cord-337137-0ey40gzw 151 11 - - HYPH cord-337137-0ey40gzw 151 12 CoV CoV NNP cord-337137-0ey40gzw 151 13 infection infection NN cord-337137-0ey40gzw 151 14 , , , cord-337137-0ey40gzw 151 15 IgM IgM NNP cord-337137-0ey40gzw 151 16 and and CC cord-337137-0ey40gzw 151 17 IgG IgG NNP cord-337137-0ey40gzw 151 18 autoantibodies autoantibody NNS cord-337137-0ey40gzw 151 19 against against IN cord-337137-0ey40gzw 151 20 antigens antigen NNS cord-337137-0ey40gzw 151 21 located locate VBN cord-337137-0ey40gzw 151 22 in in IN cord-337137-0ey40gzw 151 23 the the DT cord-337137-0ey40gzw 151 24 cytoplasm cytoplasm NN cord-337137-0ey40gzw 151 25 of of IN cord-337137-0ey40gzw 151 26 lung lung NN cord-337137-0ey40gzw 151 27 epithelial epithelial NN cord-337137-0ey40gzw 151 28 cells cell NNS cord-337137-0ey40gzw 151 29 ( ( -LRB- cord-337137-0ey40gzw 151 30 Figure figure NN cord-337137-0ey40gzw 151 31 4 4 CD cord-337137-0ey40gzw 151 32 ) ) -RRB- cord-337137-0ey40gzw 151 33 were be VBD cord-337137-0ey40gzw 151 34 detected detect VBN cord-337137-0ey40gzw 151 35 in in IN cord-337137-0ey40gzw 151 36 the the DT cord-337137-0ey40gzw 151 37 sera sera NNP cord-337137-0ey40gzw 151 38 of of IN cord-337137-0ey40gzw 151 39 36 36 CD cord-337137-0ey40gzw 151 40 Chinese chinese JJ cord-337137-0ey40gzw 151 41 SARS SARS NNP cord-337137-0ey40gzw 151 42 patients patient NNS cord-337137-0ey40gzw 151 43 ( ( -LRB- cord-337137-0ey40gzw 151 44 Lo Lo NNP cord-337137-0ey40gzw 151 45 , , , cord-337137-0ey40gzw 151 46 unpublished unpublished JJ cord-337137-0ey40gzw 151 47 observations observation NNS cord-337137-0ey40gzw 151 48 ) ) -RRB- cord-337137-0ey40gzw 151 49 . . . cord-337137-0ey40gzw 152 1 In in IN cord-337137-0ey40gzw 152 2 another another DT cord-337137-0ey40gzw 152 3 cohort cohort NN cord-337137-0ey40gzw 152 4 of of IN cord-337137-0ey40gzw 152 5 22 22 CD cord-337137-0ey40gzw 152 6 SARS SARS NNP cord-337137-0ey40gzw 152 7 patients patient NNS cord-337137-0ey40gzw 152 8 , , , cord-337137-0ey40gzw 152 9 immune immune JJ cord-337137-0ey40gzw 152 10 activity activity NN cord-337137-0ey40gzw 152 11 against against IN cord-337137-0ey40gzw 152 12 antigens antigen NNS cord-337137-0ey40gzw 152 13 from from IN cord-337137-0ey40gzw 152 14 lung lung NN cord-337137-0ey40gzw 152 15 epithelial epithelial JJ cord-337137-0ey40gzw 152 16 cell cell NN cord-337137-0ey40gzw 152 17 lines line NNS cord-337137-0ey40gzw 152 18 and and CC cord-337137-0ey40gzw 152 19 endothelial endothelial JJ cord-337137-0ey40gzw 152 20 cell cell NN cord-337137-0ey40gzw 152 21 lines line NNS cord-337137-0ey40gzw 152 22 was be VBD cord-337137-0ey40gzw 152 23 found find VBN cord-337137-0ey40gzw 152 24 in in IN cord-337137-0ey40gzw 152 25 some some DT cord-337137-0ey40gzw 152 26 patients patient NNS cord-337137-0ey40gzw 152 27 ' ' POS cord-337137-0ey40gzw 152 28 sera sera NNP cord-337137-0ey40gzw 152 29 obtained obtain VBD cord-337137-0ey40gzw 152 30 approximately approximately RB cord-337137-0ey40gzw 152 31 1 1 CD cord-337137-0ey40gzw 152 32 month month NN cord-337137-0ey40gzw 152 33 after after IN cord-337137-0ey40gzw 152 34 infection infection NN cord-337137-0ey40gzw 152 35 [ [ -LRB- cord-337137-0ey40gzw 152 36 78 78 CD cord-337137-0ey40gzw 152 37 ] ] -RRB- cord-337137-0ey40gzw 152 38 . . . cord-337137-0ey40gzw 153 1 Moreover moreover RB cord-337137-0ey40gzw 153 2 , , , cord-337137-0ey40gzw 153 3 high high JJ cord-337137-0ey40gzw 153 4 levels level NNS cord-337137-0ey40gzw 153 5 of of IN cord-337137-0ey40gzw 153 6 these these DT cord-337137-0ey40gzw 153 7 autoimmune autoimmune JJ cord-337137-0ey40gzw 153 8 activities activity NNS cord-337137-0ey40gzw 153 9 in in IN cord-337137-0ey40gzw 153 10 the the DT cord-337137-0ey40gzw 153 11 sera sera NNP cord-337137-0ey40gzw 153 12 were be VBD cord-337137-0ey40gzw 153 13 shown show VBN cord-337137-0ey40gzw 153 14 to to TO cord-337137-0ey40gzw 153 15 be be VB cord-337137-0ey40gzw 153 16 cytotoxic cytotoxic JJ cord-337137-0ey40gzw 153 17 to to TO cord-337137-0ey40gzw 153 18 lung lung NN cord-337137-0ey40gzw 153 19 epithelial epithelial JJ cord-337137-0ey40gzw 153 20 cells cell NNS cord-337137-0ey40gzw 153 21 and and CC cord-337137-0ey40gzw 153 22 endothelial endothelial JJ cord-337137-0ey40gzw 153 23 cells cell NNS cord-337137-0ey40gzw 153 24 in in IN cord-337137-0ey40gzw 153 25 culture culture NN cord-337137-0ey40gzw 153 26 . . . cord-337137-0ey40gzw 154 1 Autoimmune autoimmune JJ cord-337137-0ey40gzw 154 2 antibodies antibody NNS cord-337137-0ey40gzw 154 3 may may MD cord-337137-0ey40gzw 154 4 be be VB cord-337137-0ey40gzw 154 5 important important JJ cord-337137-0ey40gzw 154 6 in in IN cord-337137-0ey40gzw 154 7 mediating mediate VBG cord-337137-0ey40gzw 154 8 tissue tissue NN cord-337137-0ey40gzw 154 9 damage damage NN cord-337137-0ey40gzw 154 10 at at IN cord-337137-0ey40gzw 154 11 certain certain JJ cord-337137-0ey40gzw 154 12 stages stage NNS cord-337137-0ey40gzw 154 13 of of IN cord-337137-0ey40gzw 154 14 the the DT cord-337137-0ey40gzw 154 15 disease disease NN cord-337137-0ey40gzw 154 16 . . . cord-337137-0ey40gzw 155 1 The the DT cord-337137-0ey40gzw 155 2 cause cause NN cord-337137-0ey40gzw 155 3 of of IN cord-337137-0ey40gzw 155 4 the the DT cord-337137-0ey40gzw 155 5 autoimmunity autoimmunity NN cord-337137-0ey40gzw 155 6 is be VBZ cord-337137-0ey40gzw 155 7 not not RB cord-337137-0ey40gzw 155 8 fully fully RB cord-337137-0ey40gzw 155 9 understood understand VBN cord-337137-0ey40gzw 155 10 . . . cord-337137-0ey40gzw 156 1 These these DT cord-337137-0ey40gzw 156 2 autoantibodies autoantibody NNS cord-337137-0ey40gzw 156 3 may may MD cord-337137-0ey40gzw 156 4 be be VB cord-337137-0ey40gzw 156 5 the the DT cord-337137-0ey40gzw 156 6 result result NN cord-337137-0ey40gzw 156 7 of of IN cord-337137-0ey40gzw 156 8 humoral humoral JJ cord-337137-0ey40gzw 156 9 responses response NNS cord-337137-0ey40gzw 156 10 to to TO cord-337137-0ey40gzw 156 11 innate innate JJ cord-337137-0ey40gzw 156 12 antigens antigen NNS cord-337137-0ey40gzw 156 13 exposed expose VBN cord-337137-0ey40gzw 156 14 accidentally accidentally RB cord-337137-0ey40gzw 156 15 during during IN cord-337137-0ey40gzw 156 16 direct direct JJ cord-337137-0ey40gzw 156 17 damage damage NN cord-337137-0ey40gzw 156 18 of of IN cord-337137-0ey40gzw 156 19 the the DT cord-337137-0ey40gzw 156 20 lung lung NN cord-337137-0ey40gzw 156 21 and and CC cord-337137-0ey40gzw 156 22 , , , cord-337137-0ey40gzw 156 23 perhaps perhaps RB cord-337137-0ey40gzw 156 24 , , , cord-337137-0ey40gzw 156 25 the the DT cord-337137-0ey40gzw 156 26 endothelium endothelium NN cord-337137-0ey40gzw 156 27 by by IN cord-337137-0ey40gzw 156 28 SARS SARS NNP cord-337137-0ey40gzw 156 29 - - HYPH cord-337137-0ey40gzw 156 30 CoV. CoV. NNP cord-337137-0ey40gzw 157 1 Alternatively alternatively RB cord-337137-0ey40gzw 157 2 , , , cord-337137-0ey40gzw 157 3 autoimmunity autoimmunity NN cord-337137-0ey40gzw 157 4 may may MD cord-337137-0ey40gzw 157 5 be be VB cord-337137-0ey40gzw 157 6 due due JJ cord-337137-0ey40gzw 157 7 to to IN cord-337137-0ey40gzw 157 8 crossreactivity crossreactivity NN cord-337137-0ey40gzw 157 9 of of IN cord-337137-0ey40gzw 157 10 antibodies antibody NNS cord-337137-0ey40gzw 157 11 against against IN cord-337137-0ey40gzw 157 12 some some DT cord-337137-0ey40gzw 157 13 specific specific JJ cord-337137-0ey40gzw 157 14 epitopes epitope NNS cord-337137-0ey40gzw 157 15 of of IN cord-337137-0ey40gzw 157 16 the the DT cord-337137-0ey40gzw 157 17 SARS SARS NNP cord-337137-0ey40gzw 157 18 - - HYPH cord-337137-0ey40gzw 157 19 CoV cov NN cord-337137-0ey40gzw 157 20 proteins protein NNS cord-337137-0ey40gzw 157 21 . . . cord-337137-0ey40gzw 158 1 The the DT cord-337137-0ey40gzw 158 2 chemokines chemokine NNS cord-337137-0ey40gzw 158 3 are be VBP cord-337137-0ey40gzw 158 4 a a DT cord-337137-0ey40gzw 158 5 family family NN cord-337137-0ey40gzw 158 6 of of IN cord-337137-0ey40gzw 158 7 small small JJ cord-337137-0ey40gzw 158 8 proteins protein NNS cord-337137-0ey40gzw 158 9 that that WDT cord-337137-0ey40gzw 158 10 play play VBP cord-337137-0ey40gzw 158 11 important important JJ cord-337137-0ey40gzw 158 12 roles role NNS cord-337137-0ey40gzw 158 13 in in IN cord-337137-0ey40gzw 158 14 intercellular intercellular JJ cord-337137-0ey40gzw 158 15 signalling signalling NN cord-337137-0ey40gzw 158 16 and and CC cord-337137-0ey40gzw 158 17 chemotaxis chemotaxis NN cord-337137-0ey40gzw 158 18 . . . cord-337137-0ey40gzw 159 1 Based base VBN cord-337137-0ey40gzw 159 2 on on IN cord-337137-0ey40gzw 159 3 their -PRON- PRP$ cord-337137-0ey40gzw 159 4 protein protein NN cord-337137-0ey40gzw 159 5 sequences sequence NNS cord-337137-0ey40gzw 159 6 , , , cord-337137-0ey40gzw 159 7 they -PRON- PRP cord-337137-0ey40gzw 159 8 are be VBP cord-337137-0ey40gzw 159 9 broadly broadly RB cord-337137-0ey40gzw 159 10 divided divide VBN cord-337137-0ey40gzw 159 11 into into IN cord-337137-0ey40gzw 159 12 α α NN cord-337137-0ey40gzw 159 13 - - HYPH cord-337137-0ey40gzw 159 14 chemokines chemokine NNS cord-337137-0ey40gzw 159 15 with with IN cord-337137-0ey40gzw 159 16 a a DT cord-337137-0ey40gzw 159 17 common common JJ cord-337137-0ey40gzw 159 18 C c NN cord-337137-0ey40gzw 159 19 - - HYPH cord-337137-0ey40gzw 159 20 X x NN cord-337137-0ey40gzw 159 21 - - HYPH cord-337137-0ey40gzw 159 22 C c NN cord-337137-0ey40gzw 159 23 ( ( -LRB- cord-337137-0ey40gzw 159 24 cysteine cysteine NN cord-337137-0ey40gzw 159 25 - - HYPH cord-337137-0ey40gzw 159 26 other other JJ cord-337137-0ey40gzw 159 27 - - HYPH cord-337137-0ey40gzw 159 28 cysteine cysteine NN cord-337137-0ey40gzw 159 29 ) ) -RRB- cord-337137-0ey40gzw 159 30 structure structure NN cord-337137-0ey40gzw 159 31 of of IN cord-337137-0ey40gzw 159 32 amino amino NN cord-337137-0ey40gzw 159 33 acid acid NN cord-337137-0ey40gzw 159 34 residues residue NNS cord-337137-0ey40gzw 159 35 near near IN cord-337137-0ey40gzw 159 36 the the DT cord-337137-0ey40gzw 159 37 amino amino NN cord-337137-0ey40gzw 159 38 - - HYPH cord-337137-0ey40gzw 159 39 terminus terminus NN cord-337137-0ey40gzw 159 40 which which WDT cord-337137-0ey40gzw 159 41 interacts interact VBZ cord-337137-0ey40gzw 159 42 predominantly predominantly RB cord-337137-0ey40gzw 159 43 with with IN cord-337137-0ey40gzw 159 44 neutrophils neutrophil NNS cord-337137-0ey40gzw 159 45 , , , cord-337137-0ey40gzw 159 46 and and CC cord-337137-0ey40gzw 159 47 β β NN cord-337137-0ey40gzw 159 48 - - HYPH cord-337137-0ey40gzw 159 49 chemokines chemokines NNPS cord-337137-0ey40gzw 159 50 with with IN cord-337137-0ey40gzw 159 51 a a DT cord-337137-0ey40gzw 159 52 C C NNP cord-337137-0ey40gzw 159 53 - - HYPH cord-337137-0ey40gzw 159 54 C c NN cord-337137-0ey40gzw 159 55 ( ( -LRB- cord-337137-0ey40gzw 159 56 cysteine cysteine NN cord-337137-0ey40gzw 159 57 - - HYPH cord-337137-0ey40gzw 159 58 cysteine cysteine NN cord-337137-0ey40gzw 159 59 ) ) -RRB- cord-337137-0ey40gzw 159 60 structure structure NN cord-337137-0ey40gzw 159 61 interacting interact VBG cord-337137-0ey40gzw 159 62 with with IN cord-337137-0ey40gzw 159 63 mononuclear mononuclear JJ cord-337137-0ey40gzw 159 64 cells cell NNS cord-337137-0ey40gzw 159 65 . . . cord-337137-0ey40gzw 160 1 Recently recently RB cord-337137-0ey40gzw 160 2 , , , cord-337137-0ey40gzw 160 3 chemokines chemokine NNS cord-337137-0ey40gzw 160 4 have have VBP cord-337137-0ey40gzw 160 5 been be VBN cord-337137-0ey40gzw 160 6 recognized recognize VBN cord-337137-0ey40gzw 160 7 for for IN cord-337137-0ey40gzw 160 8 their -PRON- PRP$ cord-337137-0ey40gzw 160 9 roles role NNS cord-337137-0ey40gzw 160 10 in in IN cord-337137-0ey40gzw 160 11 integrating integrate VBG cord-337137-0ey40gzw 160 12 the the DT cord-337137-0ey40gzw 160 13 innate innate JJ cord-337137-0ey40gzw 160 14 and and CC cord-337137-0ey40gzw 160 15 adaptive adaptive JJ cord-337137-0ey40gzw 160 16 immune immune JJ cord-337137-0ey40gzw 160 17 responses response NNS cord-337137-0ey40gzw 160 18 to to IN cord-337137-0ey40gzw 160 19 viral viral JJ cord-337137-0ey40gzw 160 20 infection infection NN cord-337137-0ey40gzw 160 21 through through IN cord-337137-0ey40gzw 160 22 a a DT cord-337137-0ey40gzw 160 23 cytokine cytokine NN cord-337137-0ey40gzw 160 24 - - HYPH cord-337137-0ey40gzw 160 25 to to IN cord-337137-0ey40gzw 160 26 - - HYPH cord-337137-0ey40gzw 160 27 chemokine chemokine NN cord-337137-0ey40gzw 160 28 - - HYPH cord-337137-0ey40gzw 160 29 to to IN cord-337137-0ey40gzw 160 30 - - HYPH cord-337137-0ey40gzw 160 31 cytokine cytokine NN cord-337137-0ey40gzw 160 32 signalling signalling NN cord-337137-0ey40gzw 160 33 cascade cascade NN cord-337137-0ey40gzw 160 34 [ [ -LRB- cord-337137-0ey40gzw 160 35 79 79 CD cord-337137-0ey40gzw 160 36 ] ] -RRB- cord-337137-0ey40gzw 160 37 [ [ -LRB- cord-337137-0ey40gzw 160 38 80 80 CD cord-337137-0ey40gzw 160 39 ] ] -RRB- cord-337137-0ey40gzw 160 40 [ [ -LRB- cord-337137-0ey40gzw 160 41 81 81 CD cord-337137-0ey40gzw 160 42 ] ] -RRB- cord-337137-0ey40gzw 160 43 . . . cord-337137-0ey40gzw 161 1 A a DT cord-337137-0ey40gzw 161 2 global global JJ cord-337137-0ey40gzw 161 3 view view NN cord-337137-0ey40gzw 161 4 of of IN cord-337137-0ey40gzw 161 5 the the DT cord-337137-0ey40gzw 161 6 spectrum spectrum NN cord-337137-0ey40gzw 161 7 of of IN cord-337137-0ey40gzw 161 8 expression expression NN cord-337137-0ey40gzw 161 9 of of IN cord-337137-0ey40gzw 161 10 the the DT cord-337137-0ey40gzw 161 11 immune immune JJ cord-337137-0ey40gzw 161 12 mediators mediator NNS cord-337137-0ey40gzw 161 13 was be VBD cord-337137-0ey40gzw 161 14 studied study VBN cord-337137-0ey40gzw 161 15 in in IN cord-337137-0ey40gzw 161 16 SARS SARS NNP cord-337137-0ey40gzw 161 17 by by IN cord-337137-0ey40gzw 161 18 measuring measure VBG cord-337137-0ey40gzw 161 19 the the DT cord-337137-0ey40gzw 161 20 circulating circulate VBG cord-337137-0ey40gzw 161 21 concentrations concentration NNS cord-337137-0ey40gzw 161 22 of of IN cord-337137-0ey40gzw 161 23 these these DT cord-337137-0ey40gzw 161 24 mediators mediator NNS cord-337137-0ey40gzw 161 25 at at IN cord-337137-0ey40gzw 161 26 different different JJ cord-337137-0ey40gzw 161 27 stages stage NNS cord-337137-0ey40gzw 161 28 of of IN cord-337137-0ey40gzw 161 29 the the DT cord-337137-0ey40gzw 161 30 disease disease NN cord-337137-0ey40gzw 161 31 . . . cord-337137-0ey40gzw 162 1 Most Most JJS cord-337137-0ey40gzw 162 2 cytokines cytokine NNS cord-337137-0ey40gzw 162 3 showed show VBD cord-337137-0ey40gzw 162 4 only only RB cord-337137-0ey40gzw 162 5 transient transient JJ cord-337137-0ey40gzw 162 6 and and CC cord-337137-0ey40gzw 162 7 short short RB cord-337137-0ey40gzw 162 8 - - HYPH cord-337137-0ey40gzw 162 9 lived live VBN cord-337137-0ey40gzw 162 10 activation activation NN cord-337137-0ey40gzw 162 11 in in IN cord-337137-0ey40gzw 162 12 patients patient NNS cord-337137-0ey40gzw 162 13 after after IN cord-337137-0ey40gzw 162 14 SARS SARS NNP cord-337137-0ey40gzw 162 15 - - HYPH cord-337137-0ey40gzw 162 16 CoV CoV NNP cord-337137-0ey40gzw 162 17 infection infection NN cord-337137-0ey40gzw 162 18 [ [ -LRB- cord-337137-0ey40gzw 162 19 82 82 CD cord-337137-0ey40gzw 162 20 ] ] -RRB- cord-337137-0ey40gzw 162 21 . . . cord-337137-0ey40gzw 163 1 Even even RB cord-337137-0ey40gzw 163 2 in in IN cord-337137-0ey40gzw 163 3 patients patient NNS cord-337137-0ey40gzw 163 4 who who WP cord-337137-0ey40gzw 163 5 developed develop VBD cord-337137-0ey40gzw 163 6 DAD DAD NNP cord-337137-0ey40gzw 163 7 , , , cord-337137-0ey40gzw 163 8 most most JJS cord-337137-0ey40gzw 163 9 cytokine cytokine JJ cord-337137-0ey40gzw 163 10 concentrations concentration NNS cord-337137-0ey40gzw 163 11 were be VBD cord-337137-0ey40gzw 163 12 not not RB cord-337137-0ey40gzw 163 13 significantly significantly RB cord-337137-0ey40gzw 163 14 increased increase VBN cord-337137-0ey40gzw 163 15 [ [ -LRB- cord-337137-0ey40gzw 163 16 83 83 CD cord-337137-0ey40gzw 163 17 ] ] -RRB- cord-337137-0ey40gzw 163 18 . . . cord-337137-0ey40gzw 164 1 In in IN cord-337137-0ey40gzw 164 2 contrast contrast NN cord-337137-0ey40gzw 164 3 , , , cord-337137-0ey40gzw 164 4 circulating circulate VBG cord-337137-0ey40gzw 164 5 concentrations concentration NNS cord-337137-0ey40gzw 164 6 of of IN cord-337137-0ey40gzw 164 7 several several JJ cord-337137-0ey40gzw 164 8 chemokines chemokine NNS cord-337137-0ey40gzw 164 9 , , , cord-337137-0ey40gzw 164 10 including include VBG cord-337137-0ey40gzw 164 11 CXCL9 CXCL9 NNP cord-337137-0ey40gzw 165 1 ( ( -LRB- cord-337137-0ey40gzw 165 2 chemokine chemokine NNP cord-337137-0ey40gzw 165 3 C C NNP cord-337137-0ey40gzw 165 4 - - HYPH cord-337137-0ey40gzw 165 5 X x NN cord-337137-0ey40gzw 165 6 - - HYPH cord-337137-0ey40gzw 165 7 C c NN cord-337137-0ey40gzw 165 8 motif motif NN cord-337137-0ey40gzw 165 9 ligand ligand NN cord-337137-0ey40gzw 165 10 9 9 CD cord-337137-0ey40gzw 165 11 or or CC cord-337137-0ey40gzw 165 12 monokine monokine JJ cord-337137-0ey40gzw 165 13 induced induce VBN cord-337137-0ey40gzw 165 14 by by IN cord-337137-0ey40gzw 165 15 γ γ NNP cord-337137-0ey40gzw 165 16 -interferon -interferon NN cord-337137-0ey40gzw 165 17 ) ) -RRB- cord-337137-0ey40gzw 165 18 , , , cord-337137-0ey40gzw 165 19 CXCL10 CXCL10 NNP cord-337137-0ey40gzw 165 20 ( ( -LRB- cord-337137-0ey40gzw 165 21 chemokine chemokine NN cord-337137-0ey40gzw 165 22 C C NNP cord-337137-0ey40gzw 165 23 - - HYPH cord-337137-0ey40gzw 165 24 X x NN cord-337137-0ey40gzw 165 25 - - HYPH cord-337137-0ey40gzw 165 26 C c NN cord-337137-0ey40gzw 165 27 motif motif NN cord-337137-0ey40gzw 165 28 ligand ligand NN cord-337137-0ey40gzw 165 29 10 10 CD cord-337137-0ey40gzw 165 30 or or CC cord-337137-0ey40gzw 165 31 interferoninducible interferoninducible NNP cord-337137-0ey40gzw 165 32 protein-10 protein-10 CD cord-337137-0ey40gzw 165 33 ) ) -RRB- cord-337137-0ey40gzw 165 34 , , , cord-337137-0ey40gzw 165 35 and and CC cord-337137-0ey40gzw 165 36 CCL2 CCL2 NNP cord-337137-0ey40gzw 165 37 ( ( -LRB- cord-337137-0ey40gzw 165 38 C C NNP cord-337137-0ey40gzw 165 39 - - HYPH cord-337137-0ey40gzw 165 40 C c NN cord-337137-0ey40gzw 165 41 motif motif NN cord-337137-0ey40gzw 165 42 ligand ligand NN cord-337137-0ey40gzw 165 43 2 2 CD cord-337137-0ey40gzw 165 44 or or CC cord-337137-0ey40gzw 165 45 monocyte monocyte NNP cord-337137-0ey40gzw 165 46 chemoattractant chemoattractant NNP cord-337137-0ey40gzw 165 47 protein-1 protein-1 NNP cord-337137-0ey40gzw 165 48 ) ) -RRB- cord-337137-0ey40gzw 165 49 , , , cord-337137-0ey40gzw 165 50 were be VBD cord-337137-0ey40gzw 165 51 markedly markedly RB cord-337137-0ey40gzw 165 52 increased increase VBN cord-337137-0ey40gzw 165 53 in in IN cord-337137-0ey40gzw 165 54 SARS SARS NNP cord-337137-0ey40gzw 165 55 patients patient NNS cord-337137-0ey40gzw 165 56 [ [ -LRB- cord-337137-0ey40gzw 165 57 82 82 CD cord-337137-0ey40gzw 165 58 , , , cord-337137-0ey40gzw 165 59 84 84 CD cord-337137-0ey40gzw 165 60 , , , cord-337137-0ey40gzw 165 61 85 85 CD cord-337137-0ey40gzw 165 62 ] ] -RRB- cord-337137-0ey40gzw 165 63 . . . cord-337137-0ey40gzw 166 1 Remarkably remarkably RB cord-337137-0ey40gzw 166 2 , , , cord-337137-0ey40gzw 166 3 the the DT cord-337137-0ey40gzw 166 4 circulating circulate VBG cord-337137-0ey40gzw 166 5 concentration concentration NN cord-337137-0ey40gzw 166 6 of of IN cord-337137-0ey40gzw 166 7 CXCL10 CXCL10 NNP cord-337137-0ey40gzw 166 8 measured measure VBN cord-337137-0ey40gzw 166 9 early early RB cord-337137-0ey40gzw 166 10 after after IN cord-337137-0ey40gzw 166 11 infection infection NN cord-337137-0ey40gzw 166 12 is be VBZ cord-337137-0ey40gzw 166 13 an an DT cord-337137-0ey40gzw 166 14 independent independent JJ cord-337137-0ey40gzw 166 15 prognostic prognostic JJ cord-337137-0ey40gzw 166 16 indicator indicator NN cord-337137-0ey40gzw 166 17 of of IN cord-337137-0ey40gzw 166 18 disease disease NN cord-337137-0ey40gzw 166 19 outcome outcome NN cord-337137-0ey40gzw 166 20 [ [ -LRB- cord-337137-0ey40gzw 166 21 86 86 CD cord-337137-0ey40gzw 166 22 ] ] -RRB- cord-337137-0ey40gzw 166 23 . . . cord-337137-0ey40gzw 167 1 These these DT cord-337137-0ey40gzw 167 2 chemokines chemokine NNS cord-337137-0ey40gzw 167 3 therefore therefore RB cord-337137-0ey40gzw 167 4 appear appear VBP cord-337137-0ey40gzw 167 5 to to TO cord-337137-0ey40gzw 167 6 be be VB cord-337137-0ey40gzw 167 7 important important JJ cord-337137-0ey40gzw 167 8 elements element NNS cord-337137-0ey40gzw 167 9 of of IN cord-337137-0ey40gzw 167 10 the the DT cord-337137-0ey40gzw 167 11 pathogenesis pathogenesis NN cord-337137-0ey40gzw 167 12 of of IN cord-337137-0ey40gzw 167 13 SARS SARS NNP cord-337137-0ey40gzw 167 14 . . . cord-337137-0ey40gzw 168 1 In in IN cord-337137-0ey40gzw 168 2 the the DT cord-337137-0ey40gzw 168 3 lung lung NN cord-337137-0ey40gzw 168 4 tissues tissue NNS cord-337137-0ey40gzw 168 5 obtained obtain VBN cord-337137-0ey40gzw 168 6 from from IN cord-337137-0ey40gzw 168 7 seven seven CD cord-337137-0ey40gzw 168 8 SARS SARS NNP cord-337137-0ey40gzw 168 9 patients patient NNS cord-337137-0ey40gzw 168 10 who who WP cord-337137-0ey40gzw 168 11 died die VBD cord-337137-0ey40gzw 168 12 [ [ -LRB- cord-337137-0ey40gzw 168 13 86 86 CD cord-337137-0ey40gzw 168 14 ] ] -RRB- cord-337137-0ey40gzw 168 15 , , , cord-337137-0ey40gzw 168 16 chemokines chemokine NNS cord-337137-0ey40gzw 168 17 CXCL10 CXCL10 . cord-337137-0ey40gzw 169 1 ( ( -LRB- cord-337137-0ey40gzw 169 2 Figure figure NN cord-337137-0ey40gzw 169 3 5 5 CD cord-337137-0ey40gzw 169 4 ) ) -RRB- cord-337137-0ey40gzw 169 5 and and CC cord-337137-0ey40gzw 169 6 IL-18 IL-18 NNP cord-337137-0ey40gzw 169 7 were be VBD cord-337137-0ey40gzw 169 8 markedly markedly RB cord-337137-0ey40gzw 169 9 activated activate VBN cord-337137-0ey40gzw 169 10 ( ( -LRB- cord-337137-0ey40gzw 170 1 25and 25and LS cord-337137-0ey40gzw 170 2 40-fold 40-fold CD cord-337137-0ey40gzw 170 3 compared compare VBN cord-337137-0ey40gzw 170 4 with with IN cord-337137-0ey40gzw 170 5 controls control NNS cord-337137-0ey40gzw 170 6 , , , cord-337137-0ey40gzw 170 7 respectively respectively RB cord-337137-0ey40gzw 170 8 ) ) -RRB- cord-337137-0ey40gzw 170 9 . . . cord-337137-0ey40gzw 171 1 The the DT cord-337137-0ey40gzw 171 2 important important JJ cord-337137-0ey40gzw 171 3 roles role NNS cord-337137-0ey40gzw 171 4 of of IN cord-337137-0ey40gzw 171 5 chemokines chemokine NNS cord-337137-0ey40gzw 171 6 are be VBP cord-337137-0ey40gzw 171 7 underscored underscore VBN cord-337137-0ey40gzw 171 8 by by IN cord-337137-0ey40gzw 171 9 the the DT cord-337137-0ey40gzw 171 10 findings finding NNS cord-337137-0ey40gzw 171 11 in in IN cord-337137-0ey40gzw 171 12 an an DT cord-337137-0ey40gzw 171 13 experimental experimental JJ cord-337137-0ey40gzw 171 14 mouse mouse NN cord-337137-0ey40gzw 171 15 model model NN cord-337137-0ey40gzw 171 16 of of IN cord-337137-0ey40gzw 171 17 SARS SARS NNP cord-337137-0ey40gzw 171 18 - - HYPH cord-337137-0ey40gzw 171 19 CoV CoV NNP cord-337137-0ey40gzw 171 20 infection infection NN cord-337137-0ey40gzw 171 21 in in IN cord-337137-0ey40gzw 171 22 which which WDT cord-337137-0ey40gzw 171 23 CXCL10 CXCL10 NNP cord-337137-0ey40gzw 171 24 and and CC cord-337137-0ey40gzw 171 25 a a DT cord-337137-0ey40gzw 171 26 neutrophil neutrophil NN cord-337137-0ey40gzw 171 27 chemokine chemokine NN cord-337137-0ey40gzw 171 28 , , , cord-337137-0ey40gzw 171 29 CXCL8 CXCL8 NNP cord-337137-0ey40gzw 171 30 ( ( -LRB- cord-337137-0ey40gzw 171 31 chemokine chemokine NNP cord-337137-0ey40gzw 171 32 C C NNP cord-337137-0ey40gzw 171 33 - - HYPH cord-337137-0ey40gzw 171 34 X x NN cord-337137-0ey40gzw 171 35 - - HYPH cord-337137-0ey40gzw 171 36 C c NN cord-337137-0ey40gzw 171 37 motif motif NN cord-337137-0ey40gzw 171 38 ligand ligand NN cord-337137-0ey40gzw 171 39 8) 8) NN cord-337137-0ey40gzw 171 40 , , , cord-337137-0ey40gzw 171 41 were be VBD cord-337137-0ey40gzw 171 42 also also RB cord-337137-0ey40gzw 171 43 markedly markedly RB cord-337137-0ey40gzw 171 44 activated activate VBN cord-337137-0ey40gzw 171 45 [ [ -LRB- cord-337137-0ey40gzw 171 46 87 87 CD cord-337137-0ey40gzw 171 47 ] ] -RRB- cord-337137-0ey40gzw 171 48 . . . cord-337137-0ey40gzw 172 1 These these DT cord-337137-0ey40gzw 172 2 findings finding NNS cord-337137-0ey40gzw 172 3 in in IN cord-337137-0ey40gzw 172 4 SARS SARS NNP cord-337137-0ey40gzw 172 5 compare compare VBP cord-337137-0ey40gzw 172 6 favourably favourably RB cord-337137-0ey40gzw 172 7 with with IN cord-337137-0ey40gzw 172 8 the the DT cord-337137-0ey40gzw 172 9 specific specific JJ cord-337137-0ey40gzw 172 10 situation situation NN cord-337137-0ey40gzw 172 11 in in IN cord-337137-0ey40gzw 172 12 HIV HIV NNP cord-337137-0ey40gzw 172 13 patients patient NNS cord-337137-0ey40gzw 172 14 with with IN cord-337137-0ey40gzw 172 15 lung lung NN cord-337137-0ey40gzw 172 16 allograft allograft NN cord-337137-0ey40gzw 172 17 rejection rejection NN cord-337137-0ey40gzw 172 18 and and CC cord-337137-0ey40gzw 172 19 interstitial interstitial JJ cord-337137-0ey40gzw 172 20 alveolitis alveolitis NN cord-337137-0ey40gzw 172 21 , , , cord-337137-0ey40gzw 172 22 in in IN cord-337137-0ey40gzw 172 23 which which WDT cord-337137-0ey40gzw 172 24 similar similar JJ cord-337137-0ey40gzw 172 25 activation activation NN cord-337137-0ey40gzw 172 26 of of IN cord-337137-0ey40gzw 172 27 the the DT cord-337137-0ey40gzw 172 28 chemokine chemokine NN cord-337137-0ey40gzw 172 29 CXCL10 CXCL10 NNP cord-337137-0ey40gzw 172 30 and and CC cord-337137-0ey40gzw 172 31 its -PRON- PRP$ cord-337137-0ey40gzw 172 32 receptor receptor NN cord-337137-0ey40gzw 173 1 CXCR3 CXCR3 NNP cord-337137-0ey40gzw 174 1 ( ( -LRB- cord-337137-0ey40gzw 174 2 chemokine chemokine NNP cord-337137-0ey40gzw 174 3 C C NNP cord-337137-0ey40gzw 174 4 - - HYPH cord-337137-0ey40gzw 174 5 X x NN cord-337137-0ey40gzw 174 6 - - HYPH cord-337137-0ey40gzw 174 7 C c NN cord-337137-0ey40gzw 174 8 motif motif NN cord-337137-0ey40gzw 174 9 receptor receptor NN cord-337137-0ey40gzw 174 10 3 3 CD cord-337137-0ey40gzw 174 11 ) ) -RRB- cord-337137-0ey40gzw 174 12 was be VBD cord-337137-0ey40gzw 174 13 also also RB cord-337137-0ey40gzw 174 14 found find VBN cord-337137-0ey40gzw 174 15 [ [ -LRB- cord-337137-0ey40gzw 174 16 88 88 CD cord-337137-0ey40gzw 174 17 , , , cord-337137-0ey40gzw 174 18 89 89 CD cord-337137-0ey40gzw 174 19 ] ] -RRB- cord-337137-0ey40gzw 174 20 . . . cord-337137-0ey40gzw 175 1 Other other JJ cord-337137-0ey40gzw 175 2 than than IN cord-337137-0ey40gzw 175 3 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 175 4 , , , cord-337137-0ey40gzw 175 5 chemokines chemokine NNS cord-337137-0ey40gzw 175 6 are be VBP cord-337137-0ey40gzw 175 7 also also RB cord-337137-0ey40gzw 175 8 expressed express VBN cord-337137-0ey40gzw 175 9 and and CC cord-337137-0ey40gzw 175 10 secreted secrete VBN cord-337137-0ey40gzw 175 11 by by IN cord-337137-0ey40gzw 175 12 various various JJ cord-337137-0ey40gzw 175 13 different different JJ cord-337137-0ey40gzw 175 14 cell cell NN cord-337137-0ey40gzw 175 15 types type NNS cord-337137-0ey40gzw 175 16 . . . cord-337137-0ey40gzw 176 1 Global global JJ cord-337137-0ey40gzw 176 2 gene gene NN cord-337137-0ey40gzw 176 3 expression expression NN cord-337137-0ey40gzw 176 4 profiles profile NNS cord-337137-0ey40gzw 176 5 , , , cord-337137-0ey40gzw 176 6 generated generate VBN cord-337137-0ey40gzw 176 7 by by IN cord-337137-0ey40gzw 176 8 cDNA cDNA NNP cord-337137-0ey40gzw 176 9 microarray microarray NNP cord-337137-0ey40gzw 176 10 analysis analysis NN cord-337137-0ey40gzw 176 11 of of IN cord-337137-0ey40gzw 176 12 peripheral peripheral JJ cord-337137-0ey40gzw 176 13 blood blood NN cord-337137-0ey40gzw 176 14 mononuclear mononuclear NN cord-337137-0ey40gzw 176 15 cells cell NNS cord-337137-0ey40gzw 176 16 ( ( -LRB- cord-337137-0ey40gzw 176 17 PBMCs pbmc NNS cord-337137-0ey40gzw 176 18 ) ) -RRB- cord-337137-0ey40gzw 176 19 after after IN cord-337137-0ey40gzw 176 20 in in FW cord-337137-0ey40gzw 176 21 vitro vitro FW cord-337137-0ey40gzw 176 22 exposure exposure NN cord-337137-0ey40gzw 176 23 to to IN cord-337137-0ey40gzw 176 24 SARS SARS NNP cord-337137-0ey40gzw 176 25 - - HYPH cord-337137-0ey40gzw 176 26 CoV CoV NNP cord-337137-0ey40gzw 176 27 , , , cord-337137-0ey40gzw 176 28 also also RB cord-337137-0ey40gzw 176 29 reveal reveal VB cord-337137-0ey40gzw 176 30 the the DT cord-337137-0ey40gzw 176 31 importance importance NN cord-337137-0ey40gzw 176 32 of of IN cord-337137-0ey40gzw 176 33 chemokine chemokine NN cord-337137-0ey40gzw 176 34 activation activation NN cord-337137-0ey40gzw 176 35 . . . cord-337137-0ey40gzw 177 1 Within within IN cord-337137-0ey40gzw 177 2 1 1 CD cord-337137-0ey40gzw 177 3 day day NN cord-337137-0ey40gzw 177 4 after after IN cord-337137-0ey40gzw 177 5 exposure exposure NN cord-337137-0ey40gzw 177 6 to to IN cord-337137-0ey40gzw 177 7 the the DT cord-337137-0ey40gzw 177 8 virus virus NN cord-337137-0ey40gzw 177 9 , , , cord-337137-0ey40gzw 177 10 a a DT cord-337137-0ey40gzw 177 11 number number NN cord-337137-0ey40gzw 177 12 of of IN cord-337137-0ey40gzw 177 13 chemokines chemokine NNS cord-337137-0ey40gzw 177 14 ( ( -LRB- cord-337137-0ey40gzw 177 15 including include VBG cord-337137-0ey40gzw 177 16 CXCL10 CXCL10 NNP cord-337137-0ey40gzw 177 17 , , , cord-337137-0ey40gzw 177 18 CXCL9 CXCL9 NNP cord-337137-0ey40gzw 177 19 , , , cord-337137-0ey40gzw 177 20 and and CC cord-337137-0ey40gzw 177 21 CCL2 CCL2 NNP cord-337137-0ey40gzw 177 22 ) ) -RRB- cord-337137-0ey40gzw 177 23 were be VBD cord-337137-0ey40gzw 177 24 activated activate VBN cord-337137-0ey40gzw 177 25 [ [ -LRB- cord-337137-0ey40gzw 177 26 90 90 CD cord-337137-0ey40gzw 177 27 ] ] -RRB- cord-337137-0ey40gzw 177 28 . . . cord-337137-0ey40gzw 178 1 PBMCs pbmc NNS cord-337137-0ey40gzw 178 2 and and CC cord-337137-0ey40gzw 178 3 macrophages macrophage NNS cord-337137-0ey40gzw 178 4 do do VBP cord-337137-0ey40gzw 178 5 not not RB cord-337137-0ey40gzw 178 6 support support VB cord-337137-0ey40gzw 178 7 productive productive JJ cord-337137-0ey40gzw 178 8 infection infection NN cord-337137-0ey40gzw 178 9 as as IN cord-337137-0ey40gzw 178 10 viral viral JJ cord-337137-0ey40gzw 178 11 replication replication NN cord-337137-0ey40gzw 178 12 is be VBZ cord-337137-0ey40gzw 178 13 abortive abortive JJ cord-337137-0ey40gzw 178 14 and and CC cord-337137-0ey40gzw 178 15 no no DT cord-337137-0ey40gzw 178 16 infectious infectious JJ cord-337137-0ey40gzw 178 17 virus virus NN cord-337137-0ey40gzw 178 18 is be VBZ cord-337137-0ey40gzw 178 19 produced produce VBN cord-337137-0ey40gzw 178 20 . . . cord-337137-0ey40gzw 179 1 The the DT cord-337137-0ey40gzw 179 2 roles role NNS cord-337137-0ey40gzw 179 3 of of IN cord-337137-0ey40gzw 179 4 these these DT cord-337137-0ey40gzw 179 5 cell cell NN cord-337137-0ey40gzw 179 6 types type NNS cord-337137-0ey40gzw 179 7 in in IN cord-337137-0ey40gzw 179 8 the the DT cord-337137-0ey40gzw 179 9 pathogenesis pathogenesis NN cord-337137-0ey40gzw 179 10 of of IN cord-337137-0ey40gzw 179 11 SARS SARS NNP cord-337137-0ey40gzw 179 12 remain remain VBP cord-337137-0ey40gzw 179 13 to to TO cord-337137-0ey40gzw 179 14 be be VB cord-337137-0ey40gzw 179 15 clarified clarify VBN cord-337137-0ey40gzw 179 16 . . . cord-337137-0ey40gzw 180 1 Nonetheless nonetheless RB cord-337137-0ey40gzw 180 2 , , , cord-337137-0ey40gzw 180 3 these these DT cord-337137-0ey40gzw 180 4 easily easily RB cord-337137-0ey40gzw 180 5 obtainable obtainable JJ cord-337137-0ey40gzw 180 6 cell cell NN cord-337137-0ey40gzw 180 7 types type NNS cord-337137-0ey40gzw 180 8 provide provide VBP cord-337137-0ey40gzw 180 9 convenient convenient JJ cord-337137-0ey40gzw 180 10 experimental experimental JJ cord-337137-0ey40gzw 180 11 models model NNS cord-337137-0ey40gzw 180 12 and and CC cord-337137-0ey40gzw 180 13 allow allow VB cord-337137-0ey40gzw 180 14 some some DT cord-337137-0ey40gzw 180 15 insight insight NN cord-337137-0ey40gzw 180 16 into into IN cord-337137-0ey40gzw 180 17 the the DT cord-337137-0ey40gzw 180 18 patterns pattern NNS cord-337137-0ey40gzw 180 19 of of IN cord-337137-0ey40gzw 180 20 host host NN cord-337137-0ey40gzw 180 21 responses response NNS cord-337137-0ey40gzw 180 22 to to IN cord-337137-0ey40gzw 180 23 the the DT cord-337137-0ey40gzw 180 24 infection infection NN cord-337137-0ey40gzw 180 25 to to TO cord-337137-0ey40gzw 180 26 be be VB cord-337137-0ey40gzw 180 27 studied study VBN cord-337137-0ey40gzw 180 28 . . . cord-337137-0ey40gzw 181 1 Similar similar JJ cord-337137-0ey40gzw 181 2 findings finding NNS cord-337137-0ey40gzw 181 3 were be VBD cord-337137-0ey40gzw 181 4 also also RB cord-337137-0ey40gzw 181 5 reported report VBN cord-337137-0ey40gzw 181 6 in in IN cord-337137-0ey40gzw 181 7 other other JJ cord-337137-0ey40gzw 181 8 cell cell NN cord-337137-0ey40gzw 181 9 types type NNS cord-337137-0ey40gzw 181 10 , , , cord-337137-0ey40gzw 181 11 such such JJ cord-337137-0ey40gzw 181 12 as as IN cord-337137-0ey40gzw 181 13 dendritic dendritic JJ cord-337137-0ey40gzw 181 14 cells cell NNS cord-337137-0ey40gzw 181 15 , , , cord-337137-0ey40gzw 181 16 where where WRB cord-337137-0ey40gzw 181 17 the the DT cord-337137-0ey40gzw 181 18 cytokine cytokine JJ cord-337137-0ey40gzw 181 19 expression expression NN cord-337137-0ey40gzw 181 20 profiles profile NNS cord-337137-0ey40gzw 181 21 are be VBP cord-337137-0ey40gzw 181 22 predominantly predominantly RB cord-337137-0ey40gzw 181 23 of of IN cord-337137-0ey40gzw 181 24 inflammatory inflammatory JJ cord-337137-0ey40gzw 181 25 chemokines chemokine NNS cord-337137-0ey40gzw 181 26 CCL3 CCL3 NNP cord-337137-0ey40gzw 181 27 ( ( -LRB- cord-337137-0ey40gzw 181 28 chemokine chemokine NN cord-337137-0ey40gzw 181 29 C C NNP cord-337137-0ey40gzw 181 30 - - HYPH cord-337137-0ey40gzw 181 31 C C NNP cord-337137-0ey40gzw 181 32 motif motif NN cord-337137-0ey40gzw 181 33 ligand ligand NN cord-337137-0ey40gzw 181 34 3 3 CD cord-337137-0ey40gzw 181 35 ) ) -RRB- cord-337137-0ey40gzw 181 36 , , , cord-337137-0ey40gzw 181 37 CCL5 CCL5 NNP cord-337137-0ey40gzw 181 38 ( ( -LRB- cord-337137-0ey40gzw 181 39 chemokine chemokine NN cord-337137-0ey40gzw 181 40 C c NN cord-337137-0ey40gzw 181 41 - - HYPH cord-337137-0ey40gzw 181 42 C C NNP cord-337137-0ey40gzw 181 43 motif motif NN cord-337137-0ey40gzw 181 44 ligand ligand NN cord-337137-0ey40gzw 181 45 5 5 CD cord-337137-0ey40gzw 181 46 ) ) -RRB- cord-337137-0ey40gzw 181 47 , , . cord-337137-0ey40gzw 181 48 CXCL10 CXCL10 NNP cord-337137-0ey40gzw 181 49 , , , cord-337137-0ey40gzw 181 50 and and CC cord-337137-0ey40gzw 181 51 CCL2 CCL2 NNP cord-337137-0ey40gzw 181 52 . . . cord-337137-0ey40gzw 182 1 Unlike unlike IN cord-337137-0ey40gzw 182 2 the the DT cord-337137-0ey40gzw 182 3 usual usual JJ cord-337137-0ey40gzw 182 4 response response NN cord-337137-0ey40gzw 182 5 of of IN cord-337137-0ey40gzw 182 6 dendritic dendritic JJ cord-337137-0ey40gzw 182 7 cells cell NNS cord-337137-0ey40gzw 182 8 to to IN cord-337137-0ey40gzw 182 9 viral viral JJ cord-337137-0ey40gzw 182 10 infection infection NN cord-337137-0ey40gzw 182 11 , , , cord-337137-0ey40gzw 182 12 anti anti JJ cord-337137-0ey40gzw 182 13 - - JJ cord-337137-0ey40gzw 182 14 viral viral JJ cord-337137-0ey40gzw 182 15 cytokines cytokine NNS cord-337137-0ey40gzw 182 16 , , , cord-337137-0ey40gzw 182 17 including include VBG cord-337137-0ey40gzw 182 18 IFN IFN NNP cord-337137-0ey40gzw 182 19 - - HYPH cord-337137-0ey40gzw 182 20 α α NNP cord-337137-0ey40gzw 182 21 ( ( -LRB- cord-337137-0ey40gzw 182 22 interferonalpha interferonalpha NNP cord-337137-0ey40gzw 182 23 ) ) -RRB- cord-337137-0ey40gzw 182 24 , , , cord-337137-0ey40gzw 182 25 IFN IFN NNP cord-337137-0ey40gzw 182 26 - - HYPH cord-337137-0ey40gzw 182 27 β β NNP cord-337137-0ey40gzw 182 28 , , , cord-337137-0ey40gzw 182 29 IFN IFN NNP cord-337137-0ey40gzw 182 30 - - HYPH cord-337137-0ey40gzw 182 31 γ γ NNP cord-337137-0ey40gzw 182 32 , , , cord-337137-0ey40gzw 182 33 and and CC cord-337137-0ey40gzw 182 34 IL-12B IL-12B NNP cord-337137-0ey40gzw 182 35 , , , cord-337137-0ey40gzw 182 36 were be VBD cord-337137-0ey40gzw 182 37 not not RB cord-337137-0ey40gzw 182 38 activated activate VBN cord-337137-0ey40gzw 182 39 [ [ -LRB- cord-337137-0ey40gzw 182 40 58 58 CD cord-337137-0ey40gzw 182 41 ] ] -RRB- cord-337137-0ey40gzw 182 42 . . . cord-337137-0ey40gzw 183 1 Immunogenetics immunogenetic NNS cord-337137-0ey40gzw 183 2 of of IN cord-337137-0ey40gzw 183 3 the the DT cord-337137-0ey40gzw 183 4 host host NN cord-337137-0ey40gzw 183 5 may may MD cord-337137-0ey40gzw 183 6 affect affect VB cord-337137-0ey40gzw 183 7 the the DT cord-337137-0ey40gzw 183 8 severity severity NN cord-337137-0ey40gzw 183 9 of of IN cord-337137-0ey40gzw 183 10 SARS SARS NNP cord-337137-0ey40gzw 183 11 Other other JJ cord-337137-0ey40gzw 183 12 than than IN cord-337137-0ey40gzw 183 13 using use VBG cord-337137-0ey40gzw 183 14 serum serum NN cord-337137-0ey40gzw 183 15 inflammatory inflammatory JJ cord-337137-0ey40gzw 183 16 mediators mediator NNS cord-337137-0ey40gzw 183 17 to to TO cord-337137-0ey40gzw 183 18 reflect reflect VB cord-337137-0ey40gzw 183 19 the the DT cord-337137-0ey40gzw 183 20 different different JJ cord-337137-0ey40gzw 183 21 degree degree NN cord-337137-0ey40gzw 183 22 of of IN cord-337137-0ey40gzw 183 23 host host JJ cord-337137-0ey40gzw 183 24 inflammatory inflammatory JJ cord-337137-0ey40gzw 183 25 reaction reaction NN cord-337137-0ey40gzw 183 26 during during IN cord-337137-0ey40gzw 183 27 an an DT cord-337137-0ey40gzw 183 28 infection infection NN cord-337137-0ey40gzw 183 29 , , , cord-337137-0ey40gzw 183 30 the the DT cord-337137-0ey40gzw 183 31 intensity intensity NN cord-337137-0ey40gzw 183 32 of of IN cord-337137-0ey40gzw 183 33 the the DT cord-337137-0ey40gzw 183 34 immune immune JJ cord-337137-0ey40gzw 183 35 response response NN cord-337137-0ey40gzw 183 36 is be VBZ cord-337137-0ey40gzw 183 37 also also RB cord-337137-0ey40gzw 183 38 genetically genetically RB cord-337137-0ey40gzw 183 39 determined determined JJ cord-337137-0ey40gzw 183 40 . . . cord-337137-0ey40gzw 184 1 The the DT cord-337137-0ey40gzw 184 2 difference difference NN cord-337137-0ey40gzw 184 3 in in IN cord-337137-0ey40gzw 184 4 genetic genetic JJ cord-337137-0ey40gzw 184 5 makeup makeup NN cord-337137-0ey40gzw 184 6 between between IN cord-337137-0ey40gzw 184 7 individuals individual NNS cord-337137-0ey40gzw 184 8 is be VBZ cord-337137-0ey40gzw 184 9 mostly mostly RB cord-337137-0ey40gzw 184 10 accounted account VBN cord-337137-0ey40gzw 184 11 for for IN cord-337137-0ey40gzw 184 12 by by IN cord-337137-0ey40gzw 184 13 single single JJ cord-337137-0ey40gzw 184 14 base base NN cord-337137-0ey40gzw 184 15 differences difference NNS cord-337137-0ey40gzw 184 16 ( ( -LRB- cord-337137-0ey40gzw 184 17 single single JJ cord-337137-0ey40gzw 184 18 nucleotide nucleotide JJ cord-337137-0ey40gzw 184 19 polymorphisms polymorphism NNS cord-337137-0ey40gzw 184 20 , , , cord-337137-0ey40gzw 184 21 SNPs SNPs NNPS cord-337137-0ey40gzw 184 22 ) ) -RRB- cord-337137-0ey40gzw 184 23 . . . cord-337137-0ey40gzw 185 1 Many many JJ cord-337137-0ey40gzw 185 2 studies study NNS cord-337137-0ey40gzw 185 3 have have VBP cord-337137-0ey40gzw 185 4 shown show VBN cord-337137-0ey40gzw 185 5 an an DT cord-337137-0ey40gzw 185 6 association association NN cord-337137-0ey40gzw 185 7 between between IN cord-337137-0ey40gzw 185 8 SNPs SNPs NNPS cord-337137-0ey40gzw 185 9 and and CC cord-337137-0ey40gzw 185 10 predisposition predisposition NN cord-337137-0ey40gzw 185 11 to to IN cord-337137-0ey40gzw 185 12 ARDS ARDS NNP cord-337137-0ey40gzw 185 13 , , , cord-337137-0ey40gzw 185 14 and and CC cord-337137-0ey40gzw 185 15 survival survival NN cord-337137-0ey40gzw 185 16 after after IN cord-337137-0ey40gzw 185 17 sepsis sepsis NN cord-337137-0ey40gzw 185 18 or or CC cord-337137-0ey40gzw 185 19 other other JJ cord-337137-0ey40gzw 185 20 insults insult NNS cord-337137-0ey40gzw 185 21 [ [ -LRB- cord-337137-0ey40gzw 185 22 91 91 CD cord-337137-0ey40gzw 185 23 , , , cord-337137-0ey40gzw 185 24 92 92 CD cord-337137-0ey40gzw 185 25 ] ] -RRB- cord-337137-0ey40gzw 185 26 . . . cord-337137-0ey40gzw 186 1 In in IN cord-337137-0ey40gzw 186 2 the the DT cord-337137-0ey40gzw 186 3 context context NN cord-337137-0ey40gzw 186 4 of of IN cord-337137-0ey40gzw 186 5 predisposition predisposition NN cord-337137-0ey40gzw 186 6 to to IN cord-337137-0ey40gzw 186 7 ARDS ARDS NNP cord-337137-0ey40gzw 186 8 after after IN cord-337137-0ey40gzw 186 9 trauma trauma NN cord-337137-0ey40gzw 186 10 , , , cord-337137-0ey40gzw 186 11 among among IN cord-337137-0ey40gzw 186 12 parameters parameter NNS cord-337137-0ey40gzw 186 13 such such JJ cord-337137-0ey40gzw 186 14 as as IN cord-337137-0ey40gzw 186 15 circulating circulate VBG cord-337137-0ey40gzw 186 16 concentrations concentration NNS cord-337137-0ey40gzw 186 17 of of IN cord-337137-0ey40gzw 186 18 IL-1 IL-1 NNP cord-337137-0ey40gzw 186 19 , , , cord-337137-0ey40gzw 186 20 tumour tumour NN cord-337137-0ey40gzw 186 21 necrosis necrosis NN cord-337137-0ey40gzw 186 22 factor factor NN cord-337137-0ey40gzw 186 23 and and CC cord-337137-0ey40gzw 186 24 plasminogen plasminogen NN cord-337137-0ey40gzw 186 25 activator activator NN cord-337137-0ey40gzw 186 26 inhibitor-1 inhibitor-1 NNP cord-337137-0ey40gzw 186 27 ( ( -LRB- cord-337137-0ey40gzw 186 28 PAI-1 PAI-1 NNP cord-337137-0ey40gzw 186 29 ) ) -RRB- cord-337137-0ey40gzw 186 30 , , , cord-337137-0ey40gzw 186 31 and and CC cord-337137-0ey40gzw 186 32 the the DT cord-337137-0ey40gzw 186 33 genotype genotype NN cord-337137-0ey40gzw 186 34 of of IN cord-337137-0ey40gzw 186 35 PAI-1 PAI-1 NNP cord-337137-0ey40gzw 186 36 , , , cord-337137-0ey40gzw 186 37 insertion insertion NN cord-337137-0ey40gzw 186 38 alleles allele NNS cord-337137-0ey40gzw 186 39 at at IN cord-337137-0ey40gzw 186 40 the the DT cord-337137-0ey40gzw 186 41 promoter promoter NN cord-337137-0ey40gzw 186 42 of of IN cord-337137-0ey40gzw 186 43 PAI-1 PAI-1 NNP cord-337137-0ey40gzw 186 44 were be VBD cord-337137-0ey40gzw 186 45 associated associate VBN cord-337137-0ey40gzw 186 46 with with IN cord-337137-0ey40gzw 186 47 high high JJ cord-337137-0ey40gzw 186 48 concentrations concentration NNS cord-337137-0ey40gzw 186 49 of of IN cord-337137-0ey40gzw 186 50 PAI-1 PAI-1 NNP cord-337137-0ey40gzw 186 51 in in IN cord-337137-0ey40gzw 186 52 the the DT cord-337137-0ey40gzw 186 53 plasma plasma NN cord-337137-0ey40gzw 186 54 and and CC cord-337137-0ey40gzw 186 55 a a DT cord-337137-0ey40gzw 186 56 poor poor JJ cord-337137-0ey40gzw 186 57 survival survival NN cord-337137-0ey40gzw 186 58 rate rate NN cord-337137-0ey40gzw 186 59 [ [ -LRB- cord-337137-0ey40gzw 186 60 93 93 CD cord-337137-0ey40gzw 186 61 ] ] -RRB- cord-337137-0ey40gzw 186 62 . . . cord-337137-0ey40gzw 187 1 In in IN cord-337137-0ey40gzw 187 2 addition addition NN cord-337137-0ey40gzw 187 3 to to IN cord-337137-0ey40gzw 187 4 PAI-1 PAI-1 NNP cord-337137-0ey40gzw 187 5 , , , cord-337137-0ey40gzw 187 6 other other JJ cord-337137-0ey40gzw 187 7 genetic genetic JJ cord-337137-0ey40gzw 187 8 polymorphisms polymorphism NNS cord-337137-0ey40gzw 187 9 , , , cord-337137-0ey40gzw 187 10 such such JJ cord-337137-0ey40gzw 187 11 as as IN cord-337137-0ey40gzw 187 12 angiotensin angiotensin NN cord-337137-0ey40gzw 187 13 - - HYPH cord-337137-0ey40gzw 187 14 converting convert VBG cord-337137-0ey40gzw 187 15 enzyme enzyme NN cord-337137-0ey40gzw 187 16 ( ( -LRB- cord-337137-0ey40gzw 187 17 ACE ace NN cord-337137-0ey40gzw 187 18 ) ) -RRB- cord-337137-0ey40gzw 187 19 [ [ -LRB- cord-337137-0ey40gzw 187 20 94 94 CD cord-337137-0ey40gzw 187 21 ] ] -RRB- cord-337137-0ey40gzw 187 22 , , , cord-337137-0ey40gzw 187 23 CD14 CD14 NNP cord-337137-0ey40gzw 187 24 [ [ -LRB- cord-337137-0ey40gzw 187 25 95 95 CD cord-337137-0ey40gzw 187 26 ] ] -RRB- cord-337137-0ey40gzw 187 27 , , , cord-337137-0ey40gzw 187 28 surfactant surfactant NN cord-337137-0ey40gzw 187 29 protein protein NN cord-337137-0ey40gzw 187 30 [ [ -LRB- cord-337137-0ey40gzw 187 31 96 96 CD cord-337137-0ey40gzw 187 32 ] ] -RRB- cord-337137-0ey40gzw 187 33 , , , cord-337137-0ey40gzw 187 34 and and CC cord-337137-0ey40gzw 187 35 HLA HLA NNP cord-337137-0ey40gzw 187 36 genotypes genotype NNS cord-337137-0ey40gzw 187 37 [ [ -LRB- cord-337137-0ey40gzw 187 38 97 97 CD cord-337137-0ey40gzw 187 39 ] ] -RRB- cord-337137-0ey40gzw 187 40 , , , cord-337137-0ey40gzw 187 41 are be VBP cord-337137-0ey40gzw 187 42 also also RB cord-337137-0ey40gzw 187 43 associated associate VBN cord-337137-0ey40gzw 187 44 with with IN cord-337137-0ey40gzw 187 45 predisposition predisposition NN cord-337137-0ey40gzw 187 46 to to IN cord-337137-0ey40gzw 187 47 , , , cord-337137-0ey40gzw 187 48 severity severity NN cord-337137-0ey40gzw 187 49 , , , cord-337137-0ey40gzw 187 50 and and CC cord-337137-0ey40gzw 187 51 outcome outcome NN cord-337137-0ey40gzw 187 52 of of IN cord-337137-0ey40gzw 187 53 ARDS ARDS NNP cord-337137-0ey40gzw 187 54 . . . cord-337137-0ey40gzw 188 1 Although although IN cord-337137-0ey40gzw 188 2 SASR SASR NNP cord-337137-0ey40gzw 188 3 - - HYPH cord-337137-0ey40gzw 188 4 CoV CoV NNP cord-337137-0ey40gzw 188 5 utilizes utilize VBZ cord-337137-0ey40gzw 188 6 ACE2 ACE2 NNP cord-337137-0ey40gzw 188 7 as as IN cord-337137-0ey40gzw 188 8 its -PRON- PRP$ cord-337137-0ey40gzw 188 9 receptor receptor NN cord-337137-0ey40gzw 188 10 and and CC cord-337137-0ey40gzw 188 11 ACE2 ACE2 NNP cord-337137-0ey40gzw 188 12 is be VBZ cord-337137-0ey40gzw 188 13 known know VBN cord-337137-0ey40gzw 188 14 to to TO cord-337137-0ey40gzw 188 15 be be VB cord-337137-0ey40gzw 188 16 an an DT cord-337137-0ey40gzw 188 17 important important JJ cord-337137-0ey40gzw 188 18 protector protector NN cord-337137-0ey40gzw 188 19 of of IN cord-337137-0ey40gzw 188 20 lung lung NN cord-337137-0ey40gzw 188 21 damage damage NN cord-337137-0ey40gzw 188 22 in in IN cord-337137-0ey40gzw 188 23 experimental experimental JJ cord-337137-0ey40gzw 188 24 ARDS ARDS NNP cord-337137-0ey40gzw 188 25 , , , cord-337137-0ey40gzw 188 26 we -PRON- PRP cord-337137-0ey40gzw 188 27 and and CC cord-337137-0ey40gzw 188 28 other other JJ cord-337137-0ey40gzw 188 29 groups group NNS cord-337137-0ey40gzw 188 30 found find VBD cord-337137-0ey40gzw 188 31 no no DT cord-337137-0ey40gzw 188 32 solid solid JJ cord-337137-0ey40gzw 188 33 association association NN cord-337137-0ey40gzw 188 34 between between IN cord-337137-0ey40gzw 188 35 alleles allele NNS cord-337137-0ey40gzw 188 36 of of IN cord-337137-0ey40gzw 188 37 the the DT cord-337137-0ey40gzw 188 38 two two CD cord-337137-0ey40gzw 188 39 ACE ace NN cord-337137-0ey40gzw 188 40 genes gene NNS cord-337137-0ey40gzw 188 41 ( ( -LRB- cord-337137-0ey40gzw 188 42 ACE ACE NNP cord-337137-0ey40gzw 188 43 and and CC cord-337137-0ey40gzw 188 44 ACE2 ACE2 NNP cord-337137-0ey40gzw 188 45 ) ) -RRB- cord-337137-0ey40gzw 188 46 and and CC cord-337137-0ey40gzw 188 47 the the DT cord-337137-0ey40gzw 188 48 severity severity NN cord-337137-0ey40gzw 188 49 of of IN cord-337137-0ey40gzw 188 50 ARDS ARDS NNP cord-337137-0ey40gzw 188 51 after after IN cord-337137-0ey40gzw 188 52 SARS SARS NNP cord-337137-0ey40gzw 188 53 infection infection NN cord-337137-0ey40gzw 188 54 [ [ -LRB- cord-337137-0ey40gzw 188 55 52 52 CD cord-337137-0ey40gzw 188 56 , , , cord-337137-0ey40gzw 188 57 53 53 CD cord-337137-0ey40gzw 188 58 , , , cord-337137-0ey40gzw 188 59 98 98 CD cord-337137-0ey40gzw 188 60 ] ] -RRB- cord-337137-0ey40gzw 188 61 . . . cord-337137-0ey40gzw 189 1 Several several JJ cord-337137-0ey40gzw 189 2 immunogenetic immunogenetic JJ cord-337137-0ey40gzw 189 3 studies study NNS cord-337137-0ey40gzw 189 4 have have VBP cord-337137-0ey40gzw 189 5 been be VBN cord-337137-0ey40gzw 189 6 reported report VBN cord-337137-0ey40gzw 189 7 in in IN cord-337137-0ey40gzw 189 8 association association NN cord-337137-0ey40gzw 189 9 with with IN cord-337137-0ey40gzw 189 10 SARS SARS NNP cord-337137-0ey40gzw 189 11 infection infection NN cord-337137-0ey40gzw 189 12 . . . cord-337137-0ey40gzw 190 1 Among among IN cord-337137-0ey40gzw 190 2 37 37 CD cord-337137-0ey40gzw 190 3 Taiwanese taiwanese JJ cord-337137-0ey40gzw 190 4 SARS SARS NNP cord-337137-0ey40gzw 190 5 patients patient NNS cord-337137-0ey40gzw 190 6 , , , cord-337137-0ey40gzw 190 7 HLA HLA NNP cord-337137-0ey40gzw 190 8 - - HYPH cord-337137-0ey40gzw 190 9 B B NNP cord-337137-0ey40gzw 190 10 * * NFP cord-337137-0ey40gzw 190 11 4601 4601 CD cord-337137-0ey40gzw 190 12 was be VBD cord-337137-0ey40gzw 190 13 associated associate VBN cord-337137-0ey40gzw 190 14 with with IN cord-337137-0ey40gzw 190 15 both both DT cord-337137-0ey40gzw 190 16 predisposition predisposition NN cord-337137-0ey40gzw 190 17 to to IN cord-337137-0ey40gzw 190 18 infection infection NN cord-337137-0ey40gzw 190 19 and and CC cord-337137-0ey40gzw 190 20 severity severity NN cord-337137-0ey40gzw 190 21 of of IN cord-337137-0ey40gzw 190 22 infection infection NN cord-337137-0ey40gzw 190 23 [ [ -LRB- cord-337137-0ey40gzw 190 24 99 99 CD cord-337137-0ey40gzw 190 25 ] ] -RRB- cord-337137-0ey40gzw 190 26 . . . cord-337137-0ey40gzw 191 1 However however RB cord-337137-0ey40gzw 191 2 , , , cord-337137-0ey40gzw 191 3 the the DT cord-337137-0ey40gzw 191 4 association association NN cord-337137-0ey40gzw 191 5 of of IN cord-337137-0ey40gzw 191 6 this this DT cord-337137-0ey40gzw 191 7 allele allele NN cord-337137-0ey40gzw 191 8 was be VBD cord-337137-0ey40gzw 191 9 replicated replicate VBN cord-337137-0ey40gzw 191 10 in in IN cord-337137-0ey40gzw 191 11 another another DT cord-337137-0ey40gzw 191 12 Chinese chinese JJ cord-337137-0ey40gzw 191 13 community community NN cord-337137-0ey40gzw 191 14 of of IN cord-337137-0ey40gzw 191 15 Hong Hong NNP cord-337137-0ey40gzw 191 16 Kong Kong NNP cord-337137-0ey40gzw 191 17 involving involve VBG cord-337137-0ey40gzw 191 18 90 90 CD cord-337137-0ey40gzw 191 19 SARS SARS NNP cord-337137-0ey40gzw 191 20 patients patient NNS cord-337137-0ey40gzw 191 21 [ [ -LRB- cord-337137-0ey40gzw 191 22 100 100 CD cord-337137-0ey40gzw 191 23 ] ] -RRB- cord-337137-0ey40gzw 191 24 . . . cord-337137-0ey40gzw 192 1 HLA HLA NNP cord-337137-0ey40gzw 192 2 - - HYPH cord-337137-0ey40gzw 192 3 B B NNP cord-337137-0ey40gzw 193 1 * * NFP cord-337137-0ey40gzw 193 2 0703 0703 CD cord-337137-0ey40gzw 193 3 was be VBD cord-337137-0ey40gzw 193 4 found find VBN cord-337137-0ey40gzw 193 5 to to TO cord-337137-0ey40gzw 193 6 be be VB cord-337137-0ey40gzw 193 7 a a DT cord-337137-0ey40gzw 193 8 predisposition predisposition NN cord-337137-0ey40gzw 193 9 allele allele NN cord-337137-0ey40gzw 193 10 in in IN cord-337137-0ey40gzw 193 11 the the DT cord-337137-0ey40gzw 193 12 latter latter JJ cord-337137-0ey40gzw 193 13 study study NN cord-337137-0ey40gzw 193 14 . . . cord-337137-0ey40gzw 194 1 It -PRON- PRP cord-337137-0ey40gzw 194 2 should should MD cord-337137-0ey40gzw 194 3 be be VB cord-337137-0ey40gzw 194 4 noted note VBN cord-337137-0ey40gzw 194 5 that that IN cord-337137-0ey40gzw 194 6 this this DT cord-337137-0ey40gzw 194 7 latter latter JJ cord-337137-0ey40gzw 194 8 allele allele NN cord-337137-0ey40gzw 194 9 is be VBZ cord-337137-0ey40gzw 194 10 rare rare JJ cord-337137-0ey40gzw 194 11 and and CC cord-337137-0ey40gzw 194 12 is be VBZ cord-337137-0ey40gzw 194 13 found find VBN cord-337137-0ey40gzw 194 14 in in IN cord-337137-0ey40gzw 194 15 ∼3 ∼3 CD cord-337137-0ey40gzw 194 16 % % NN cord-337137-0ey40gzw 194 17 of of IN cord-337137-0ey40gzw 194 18 the the DT cord-337137-0ey40gzw 194 19 general general JJ cord-337137-0ey40gzw 194 20 population population NN cord-337137-0ey40gzw 194 21 . . . cord-337137-0ey40gzw 195 1 Hence hence RB cord-337137-0ey40gzw 195 2 , , , cord-337137-0ey40gzw 195 3 this this DT cord-337137-0ey40gzw 195 4 allele allele NN cord-337137-0ey40gzw 195 5 can can MD cord-337137-0ey40gzw 195 6 not not RB cord-337137-0ey40gzw 195 7 be be VB cord-337137-0ey40gzw 195 8 considered consider VBN cord-337137-0ey40gzw 195 9 a a DT cord-337137-0ey40gzw 195 10 major major JJ cord-337137-0ey40gzw 195 11 predisposition predisposition NN cord-337137-0ey40gzw 195 12 factor factor NN cord-337137-0ey40gzw 195 13 for for IN cord-337137-0ey40gzw 195 14 SARS SARS NNP cord-337137-0ey40gzw 195 15 infection infection NN cord-337137-0ey40gzw 195 16 [ [ -LRB- cord-337137-0ey40gzw 195 17 100 100 CD cord-337137-0ey40gzw 195 18 ] ] -RRB- cord-337137-0ey40gzw 195 19 . . . cord-337137-0ey40gzw 196 1 Immunogenotype Immunogenotype NNP cord-337137-0ey40gzw 196 2 may may MD cord-337137-0ey40gzw 196 3 play play VB cord-337137-0ey40gzw 196 4 a a DT cord-337137-0ey40gzw 196 5 role role NN cord-337137-0ey40gzw 196 6 in in IN cord-337137-0ey40gzw 196 7 determining determine VBG cord-337137-0ey40gzw 196 8 the the DT cord-337137-0ey40gzw 196 9 severity severity NN cord-337137-0ey40gzw 196 10 of of IN cord-337137-0ey40gzw 196 11 host host NN cord-337137-0ey40gzw 196 12 responses response NNS cord-337137-0ey40gzw 196 13 . . . cord-337137-0ey40gzw 197 1 There there EX cord-337137-0ey40gzw 197 2 is be VBZ cord-337137-0ey40gzw 197 3 considerable considerable JJ cord-337137-0ey40gzw 197 4 variability variability NN cord-337137-0ey40gzw 197 5 in in IN cord-337137-0ey40gzw 197 6 the the DT cord-337137-0ey40gzw 197 7 prevalence prevalence NN cord-337137-0ey40gzw 197 8 of of IN cord-337137-0ey40gzw 197 9 immunogenotypes immunogenotype NNS cord-337137-0ey40gzw 197 10 among among IN cord-337137-0ey40gzw 197 11 different different JJ cord-337137-0ey40gzw 197 12 populations population NNS cord-337137-0ey40gzw 197 13 and and CC cord-337137-0ey40gzw 197 14 the the DT cord-337137-0ey40gzw 197 15 significance significance NN cord-337137-0ey40gzw 197 16 of of IN cord-337137-0ey40gzw 197 17 detecting detect VBG cord-337137-0ey40gzw 197 18 so so RB cord-337137-0ey40gzw 197 19 - - HYPH cord-337137-0ey40gzw 197 20 called call VBN cord-337137-0ey40gzw 197 21 ' ' `` cord-337137-0ey40gzw 197 22 predisposing predispose VBG cord-337137-0ey40gzw 197 23 ' ' '' cord-337137-0ey40gzw 197 24 alleles allele NNS cord-337137-0ey40gzw 197 25 in in IN cord-337137-0ey40gzw 197 26 clinical clinical JJ cord-337137-0ey40gzw 197 27 practice practice NN cord-337137-0ey40gzw 197 28 is be VBZ cord-337137-0ey40gzw 197 29 questionable questionable JJ cord-337137-0ey40gzw 197 30 . . . cord-337137-0ey40gzw 198 1 More More JJR cord-337137-0ey40gzw 198 2 studies study NNS cord-337137-0ey40gzw 198 3 are be VBP cord-337137-0ey40gzw 198 4 needed need VBN cord-337137-0ey40gzw 198 5 to to TO cord-337137-0ey40gzw 198 6 uncover uncover VB cord-337137-0ey40gzw 198 7 fully fully RB cord-337137-0ey40gzw 198 8 the the DT cord-337137-0ey40gzw 198 9 real real JJ cord-337137-0ey40gzw 198 10 genetic genetic JJ cord-337137-0ey40gzw 198 11 determinants determinant NNS cord-337137-0ey40gzw 198 12 for for IN cord-337137-0ey40gzw 198 13 both both DT cord-337137-0ey40gzw 198 14 predisposition predisposition NN cord-337137-0ey40gzw 198 15 to to IN cord-337137-0ey40gzw 198 16 infection infection NN cord-337137-0ey40gzw 198 17 and and CC cord-337137-0ey40gzw 198 18 the the DT cord-337137-0ey40gzw 198 19 host host NN cord-337137-0ey40gzw 198 20 - - HYPH cord-337137-0ey40gzw 198 21 pathogen pathogen NN cord-337137-0ey40gzw 198 22 interaction interaction NN cord-337137-0ey40gzw 198 23 after after IN cord-337137-0ey40gzw 198 24 infection infection NN cord-337137-0ey40gzw 198 25 with with IN cord-337137-0ey40gzw 198 26 the the DT cord-337137-0ey40gzw 198 27 virus virus NN cord-337137-0ey40gzw 198 28 . . . cord-337137-0ey40gzw 199 1 A a DT cord-337137-0ey40gzw 199 2 considerable considerable JJ cord-337137-0ey40gzw 199 3 amount amount NN cord-337137-0ey40gzw 199 4 of of IN cord-337137-0ey40gzw 199 5 knowledge knowledge NN cord-337137-0ey40gzw 199 6 of of IN cord-337137-0ey40gzw 199 7 SARS SARS NNP cord-337137-0ey40gzw 199 8 infection infection NN cord-337137-0ey40gzw 199 9 has have VBZ cord-337137-0ey40gzw 199 10 accumulated accumulate VBN cord-337137-0ey40gzw 199 11 as as IN cord-337137-0ey40gzw 199 12 a a DT cord-337137-0ey40gzw 199 13 result result NN cord-337137-0ey40gzw 199 14 of of IN cord-337137-0ey40gzw 199 15 almost almost RB cord-337137-0ey40gzw 199 16 3 3 CD cord-337137-0ey40gzw 199 17 years year NNS cord-337137-0ey40gzw 199 18 of of IN cord-337137-0ey40gzw 199 19 research research NN cord-337137-0ey40gzw 199 20 since since IN cord-337137-0ey40gzw 199 21 the the DT cord-337137-0ey40gzw 199 22 emergence emergence NN cord-337137-0ey40gzw 199 23 of of IN cord-337137-0ey40gzw 199 24 SARS SARS NNP cord-337137-0ey40gzw 199 25 . . . cord-337137-0ey40gzw 200 1 Some some DT cord-337137-0ey40gzw 200 2 key key JJ cord-337137-0ey40gzw 200 3 issues issue NNS cord-337137-0ey40gzw 200 4 about about IN cord-337137-0ey40gzw 200 5 the the DT cord-337137-0ey40gzw 200 6 pathogen pathogen NN cord-337137-0ey40gzw 200 7 , , , cord-337137-0ey40gzw 200 8 SARS SARS NNP cord-337137-0ey40gzw 200 9 - - HYPH cord-337137-0ey40gzw 200 10 CoV CoV NNP cord-337137-0ey40gzw 200 11 , , , cord-337137-0ey40gzw 200 12 have have VBP cord-337137-0ey40gzw 200 13 been be VBN cord-337137-0ey40gzw 200 14 addressed address VBN cord-337137-0ey40gzw 200 15 . . . cord-337137-0ey40gzw 201 1 These these DT cord-337137-0ey40gzw 201 2 include include VBP cord-337137-0ey40gzw 201 3 the the DT cord-337137-0ey40gzw 201 4 rapid rapid JJ cord-337137-0ey40gzw 201 5 discovery discovery NN cord-337137-0ey40gzw 201 6 of of IN cord-337137-0ey40gzw 201 7 SARS SARS NNP cord-337137-0ey40gzw 201 8 - - HYPH cord-337137-0ey40gzw 201 9 CoV CoV NNP cord-337137-0ey40gzw 201 10 receptors receptor NNS cord-337137-0ey40gzw 201 11 and and CC cord-337137-0ey40gzw 201 12 the the DT cord-337137-0ey40gzw 201 13 actions action NNS cord-337137-0ey40gzw 201 14 of of IN cord-337137-0ey40gzw 201 15 some some DT cord-337137-0ey40gzw 201 16 of of IN cord-337137-0ey40gzw 201 17 the the DT cord-337137-0ey40gzw 201 18 specific specific JJ cord-337137-0ey40gzw 201 19 viral viral JJ cord-337137-0ey40gzw 201 20 proteins protein NNS cord-337137-0ey40gzw 201 21 in in IN cord-337137-0ey40gzw 201 22 different different JJ cord-337137-0ey40gzw 201 23 host host NN cord-337137-0ey40gzw 201 24 cells cell NNS cord-337137-0ey40gzw 201 25 . . . cord-337137-0ey40gzw 202 1 Understanding understand VBG cord-337137-0ey40gzw 202 2 the the DT cord-337137-0ey40gzw 202 3 molecular molecular JJ cord-337137-0ey40gzw 202 4 basis basis NN cord-337137-0ey40gzw 202 5 of of IN cord-337137-0ey40gzw 202 6 differences difference NNS cord-337137-0ey40gzw 202 7 in in IN cord-337137-0ey40gzw 202 8 host host NN cord-337137-0ey40gzw 202 9 cell cell NN cord-337137-0ey40gzw 202 10 responses response NNS cord-337137-0ey40gzw 202 11 to to IN cord-337137-0ey40gzw 202 12 SARS SARS NNP cord-337137-0ey40gzw 202 13 - - HYPH cord-337137-0ey40gzw 202 14 CoV CoV NNP cord-337137-0ey40gzw 202 15 infection infection NN cord-337137-0ey40gzw 202 16 will will MD cord-337137-0ey40gzw 202 17 be be VB cord-337137-0ey40gzw 202 18 crucial crucial JJ cord-337137-0ey40gzw 202 19 in in IN cord-337137-0ey40gzw 202 20 delineating delineate VBG cord-337137-0ey40gzw 202 21 its -PRON- PRP$ cord-337137-0ey40gzw 202 22 pathogenesis pathogenesis NN cord-337137-0ey40gzw 202 23 . . . cord-337137-0ey40gzw 203 1 It -PRON- PRP cord-337137-0ey40gzw 203 2 is be VBZ cord-337137-0ey40gzw 203 3 also also RB cord-337137-0ey40gzw 203 4 clear clear JJ cord-337137-0ey40gzw 203 5 from from IN cord-337137-0ey40gzw 203 6 clinical clinical JJ cord-337137-0ey40gzw 203 7 and and CC cord-337137-0ey40gzw 203 8 experimental experimental JJ cord-337137-0ey40gzw 203 9 data datum NNS cord-337137-0ey40gzw 203 10 that that WDT cord-337137-0ey40gzw 203 11 host host VBP cord-337137-0ey40gzw 203 12 immune immune JJ cord-337137-0ey40gzw 203 13 responses response NNS cord-337137-0ey40gzw 203 14 may may MD cord-337137-0ey40gzw 203 15 be be VB cord-337137-0ey40gzw 203 16 the the DT cord-337137-0ey40gzw 203 17 key key JJ cord-337137-0ey40gzw 203 18 determinant determinant NN cord-337137-0ey40gzw 203 19 in in IN cord-337137-0ey40gzw 203 20 disease disease NN cord-337137-0ey40gzw 203 21 progression progression NN cord-337137-0ey40gzw 203 22 after after IN cord-337137-0ey40gzw 203 23 initial initial JJ cord-337137-0ey40gzw 203 24 SARS SARS NNP cord-337137-0ey40gzw 203 25 - - HYPH cord-337137-0ey40gzw 203 26 CoV CoV NNP cord-337137-0ey40gzw 203 27 infection infection NN cord-337137-0ey40gzw 203 28 . . . cord-337137-0ey40gzw 204 1 Future future JJ cord-337137-0ey40gzw 204 2 studies study NNS cord-337137-0ey40gzw 204 3 aimed aim VBN cord-337137-0ey40gzw 204 4 at at IN cord-337137-0ey40gzw 204 5 characterization characterization NN cord-337137-0ey40gzw 204 6 of of IN cord-337137-0ey40gzw 204 7 the the DT cord-337137-0ey40gzw 204 8 variability variability NN cord-337137-0ey40gzw 204 9 of of IN cord-337137-0ey40gzw 204 10 host host NN cord-337137-0ey40gzw 204 11 immune immune JJ cord-337137-0ey40gzw 204 12 and and CC cord-337137-0ey40gzw 204 13 inflammatory inflammatory JJ cord-337137-0ey40gzw 204 14 responses response NNS cord-337137-0ey40gzw 204 15 will will MD cord-337137-0ey40gzw 204 16 be be VB cord-337137-0ey40gzw 204 17 important important JJ cord-337137-0ey40gzw 204 18 in in IN cord-337137-0ey40gzw 204 19 understanding understand VBG cord-337137-0ey40gzw 204 20 this this DT cord-337137-0ey40gzw 204 21 new new JJ cord-337137-0ey40gzw 204 22 emerging emerge VBG cord-337137-0ey40gzw 204 23 infectious infectious JJ cord-337137-0ey40gzw 204 24 disease disease NN cord-337137-0ey40gzw 204 25 . . . cord-337137-0ey40gzw 205 1 A a DT cord-337137-0ey40gzw 205 2 major major JJ cord-337137-0ey40gzw 205 3 outbreak outbreak NN cord-337137-0ey40gzw 205 4 of of IN cord-337137-0ey40gzw 205 5 severe severe JJ cord-337137-0ey40gzw 205 6 acute acute JJ cord-337137-0ey40gzw 205 7 respiratory respiratory JJ cord-337137-0ey40gzw 205 8 syndrome syndrome NN cord-337137-0ey40gzw 205 9 in in IN cord-337137-0ey40gzw 205 10 Hong Hong NNP cord-337137-0ey40gzw 205 11 Kong Kong NNP cord-337137-0ey40gzw 205 12 SARS SARS NNP cord-337137-0ey40gzw 205 13 -beginning -beginne VBG cord-337137-0ey40gzw 205 14 to to TO cord-337137-0ey40gzw 205 15 understand understand VB cord-337137-0ey40gzw 205 16 a a DT cord-337137-0ey40gzw 205 17 new new JJ cord-337137-0ey40gzw 205 18 virus virus NN cord-337137-0ey40gzw 205 19 Treatment treatment NN cord-337137-0ey40gzw 205 20 of of IN cord-337137-0ey40gzw 205 21 severe severe JJ cord-337137-0ey40gzw 205 22 acute acute JJ cord-337137-0ey40gzw 205 23 respiratory respiratory JJ cord-337137-0ey40gzw 205 24 syndrome syndrome NN cord-337137-0ey40gzw 206 1 Haematological Haematological NNP cord-337137-0ey40gzw 206 2 manifestations manifestation NNS cord-337137-0ey40gzw 206 3 in in IN cord-337137-0ey40gzw 206 4 patients patient NNS cord-337137-0ey40gzw 206 5 with with IN cord-337137-0ey40gzw 206 6 severe severe JJ cord-337137-0ey40gzw 206 7 acute acute JJ cord-337137-0ey40gzw 206 8 respiratory respiratory JJ cord-337137-0ey40gzw 206 9 syndrome syndrome NN cord-337137-0ey40gzw 206 10 : : : cord-337137-0ey40gzw 207 1 retrospective retrospective JJ cord-337137-0ey40gzw 207 2 analysis analysis NNP cord-337137-0ey40gzw 208 1 Enteric enteric JJ cord-337137-0ey40gzw 208 2 involvement involvement NN cord-337137-0ey40gzw 208 3 of of IN cord-337137-0ey40gzw 208 4 severe severe JJ cord-337137-0ey40gzw 208 5 acute acute JJ cord-337137-0ey40gzw 208 6 respiratory respiratory JJ cord-337137-0ey40gzw 208 7 syndromeassociated syndromeassociate VBN cord-337137-0ey40gzw 208 8 coronavirus coronavirus NN cord-337137-0ey40gzw 208 9 infection infection NN cord-337137-0ey40gzw 208 10 Retrospective retrospective JJ cord-337137-0ey40gzw 208 11 analysis analysis NN cord-337137-0ey40gzw 208 12 of of IN cord-337137-0ey40gzw 208 13 liver liver NN cord-337137-0ey40gzw 208 14 function function NN cord-337137-0ey40gzw 208 15 derangement derangement NN cord-337137-0ey40gzw 208 16 in in IN cord-337137-0ey40gzw 208 17 severe severe JJ cord-337137-0ey40gzw 208 18 acute acute JJ cord-337137-0ey40gzw 208 19 respiratory respiratory JJ cord-337137-0ey40gzw 208 20 syndrome syndrome NN cord-337137-0ey40gzw 208 21 Temporal temporal JJ cord-337137-0ey40gzw 208 22 patterns pattern NNS cord-337137-0ey40gzw 208 23 of of IN cord-337137-0ey40gzw 208 24 hepatic hepatic JJ cord-337137-0ey40gzw 208 25 dysfunction dysfunction NN cord-337137-0ey40gzw 208 26 and and CC cord-337137-0ey40gzw 208 27 disease disease NN cord-337137-0ey40gzw 208 28 severity severity NN cord-337137-0ey40gzw 208 29 in in IN cord-337137-0ey40gzw 208 30 patients patient NNS cord-337137-0ey40gzw 208 31 with with IN cord-337137-0ey40gzw 208 32 SARS SARS NNP cord-337137-0ey40gzw 208 33 Acute Acute NNP cord-337137-0ey40gzw 208 34 renal renal JJ cord-337137-0ey40gzw 208 35 impairment impairment NN cord-337137-0ey40gzw 208 36 in in IN cord-337137-0ey40gzw 208 37 coronavirus coronavirus NN cord-337137-0ey40gzw 208 38 - - HYPH cord-337137-0ey40gzw 208 39 associated associate VBN cord-337137-0ey40gzw 208 40 severe severe JJ cord-337137-0ey40gzw 208 41 acute acute JJ cord-337137-0ey40gzw 208 42 respiratory respiratory JJ cord-337137-0ey40gzw 208 43 syndrome syndrome NN cord-337137-0ey40gzw 208 44 Fatal fatal JJ cord-337137-0ey40gzw 208 45 severe severe JJ cord-337137-0ey40gzw 208 46 acute acute JJ cord-337137-0ey40gzw 208 47 respiratory respiratory JJ cord-337137-0ey40gzw 208 48 syndrome syndrome NN cord-337137-0ey40gzw 208 49 is be VBZ cord-337137-0ey40gzw 208 50 associated associate VBN cord-337137-0ey40gzw 208 51 with with IN cord-337137-0ey40gzw 208 52 multiorgan multiorgan NN cord-337137-0ey40gzw 208 53 involvement involvement NN cord-337137-0ey40gzw 208 54 by by IN cord-337137-0ey40gzw 208 55 coronavirus coronavirus NN cord-337137-0ey40gzw 208 56 Organ organ NN cord-337137-0ey40gzw 208 57 distribution distribution NN cord-337137-0ey40gzw 208 58 of of IN cord-337137-0ey40gzw 208 59 severe severe JJ cord-337137-0ey40gzw 208 60 acute acute JJ cord-337137-0ey40gzw 208 61 respiratory respiratory JJ cord-337137-0ey40gzw 208 62 syndrome syndrome NN cord-337137-0ey40gzw 208 63 ( ( -LRB- cord-337137-0ey40gzw 208 64 SARS SARS NNP cord-337137-0ey40gzw 208 65 ) ) -RRB- cord-337137-0ey40gzw 208 66 associated associate VBD cord-337137-0ey40gzw 208 67 coronavirus coronavirus NN cord-337137-0ey40gzw 208 68 ( ( -LRB- cord-337137-0ey40gzw 208 69 SARS SARS NNP cord-337137-0ey40gzw 208 70 - - HYPH cord-337137-0ey40gzw 208 71 CoV CoV NNP cord-337137-0ey40gzw 208 72 ) ) -RRB- cord-337137-0ey40gzw 208 73 in in IN cord-337137-0ey40gzw 208 74 SARS SARS NNP cord-337137-0ey40gzw 208 75 patients patient NNS cord-337137-0ey40gzw 208 76 : : : cord-337137-0ey40gzw 208 77 implications implication NNS cord-337137-0ey40gzw 208 78 for for IN cord-337137-0ey40gzw 208 79 pathogenesis pathogenesis NN cord-337137-0ey40gzw 208 80 and and CC cord-337137-0ey40gzw 208 81 virus virus NN cord-337137-0ey40gzw 208 82 transmission transmission NN cord-337137-0ey40gzw 208 83 pathways pathway NNS cord-337137-0ey40gzw 208 84 Long long JJ cord-337137-0ey40gzw 208 85 - - HYPH cord-337137-0ey40gzw 208 86 term term NN cord-337137-0ey40gzw 208 87 SARS SARS NNP cord-337137-0ey40gzw 208 88 coronavirus coronavirus NN cord-337137-0ey40gzw 208 89 excretion excretion NN cord-337137-0ey40gzw 208 90 from from IN cord-337137-0ey40gzw 208 91 patient patient JJ cord-337137-0ey40gzw 208 92 cohort cohort NN cord-337137-0ey40gzw 208 93 SARS SARS NNP cord-337137-0ey40gzw 208 94 - - HYPH cord-337137-0ey40gzw 208 95 CoV CoV NNP cord-337137-0ey40gzw 208 96 antibody antibody NN cord-337137-0ey40gzw 208 97 prevalence prevalence NN cord-337137-0ey40gzw 208 98 in in IN cord-337137-0ey40gzw 208 99 all all DT cord-337137-0ey40gzw 208 100 Hong Hong NNP cord-337137-0ey40gzw 208 101 Kong Kong NNP cord-337137-0ey40gzw 208 102 patient patient NN cord-337137-0ey40gzw 208 103 contacts contact NNS cord-337137-0ey40gzw 208 104 Severe severe JJ cord-337137-0ey40gzw 208 105 acute acute JJ cord-337137-0ey40gzw 208 106 respiratory respiratory JJ cord-337137-0ey40gzw 208 107 syndrome syndrome NN cord-337137-0ey40gzw 208 108 in in IN cord-337137-0ey40gzw 208 109 children child NNS cord-337137-0ey40gzw 208 110 : : : cord-337137-0ey40gzw 208 111 experience experience VB cord-337137-0ey40gzw 208 112 in in IN cord-337137-0ey40gzw 208 113 a a DT cord-337137-0ey40gzw 208 114 regional regional JJ cord-337137-0ey40gzw 208 115 hospital hospital NN cord-337137-0ey40gzw 208 116 in in IN cord-337137-0ey40gzw 208 117 Hong Hong NNP cord-337137-0ey40gzw 208 118 Kong Kong NNP cord-337137-0ey40gzw 209 1 The the DT cord-337137-0ey40gzw 209 2 spectrum spectrum NN cord-337137-0ey40gzw 209 3 of of IN cord-337137-0ey40gzw 209 4 pathological pathological JJ cord-337137-0ey40gzw 209 5 changes change NNS cord-337137-0ey40gzw 209 6 in in IN cord-337137-0ey40gzw 209 7 severe severe JJ cord-337137-0ey40gzw 209 8 acute acute JJ cord-337137-0ey40gzw 209 9 respiratory respiratory JJ cord-337137-0ey40gzw 209 10 syndrome syndrome NN cord-337137-0ey40gzw 209 11 ( ( -LRB- cord-337137-0ey40gzw 209 12 SARS SARS NNP cord-337137-0ey40gzw 209 13 ) ) -RRB- cord-337137-0ey40gzw 210 1 The the DT cord-337137-0ey40gzw 210 2 clinical clinical JJ cord-337137-0ey40gzw 210 3 pathology pathology NN cord-337137-0ey40gzw 210 4 of of IN cord-337137-0ey40gzw 210 5 severe severe JJ cord-337137-0ey40gzw 210 6 acute acute JJ cord-337137-0ey40gzw 210 7 respiratory respiratory JJ cord-337137-0ey40gzw 210 8 syndrome syndrome NN cord-337137-0ey40gzw 210 9 ( ( -LRB- cord-337137-0ey40gzw 210 10 SARS SARS NNP cord-337137-0ey40gzw 210 11 ) ) -RRB- cord-337137-0ey40gzw 210 12 : : : cord-337137-0ey40gzw 211 1 a a DT cord-337137-0ey40gzw 211 2 report report NN cord-337137-0ey40gzw 211 3 from from IN cord-337137-0ey40gzw 211 4 China China NNP cord-337137-0ey40gzw 211 5 Lung Lung NNP cord-337137-0ey40gzw 211 6 pathology pathology NN cord-337137-0ey40gzw 211 7 of of IN cord-337137-0ey40gzw 211 8 severe severe JJ cord-337137-0ey40gzw 211 9 acute acute JJ cord-337137-0ey40gzw 211 10 respiratory respiratory JJ cord-337137-0ey40gzw 211 11 syndrome syndrome NN cord-337137-0ey40gzw 211 12 ( ( -LRB- cord-337137-0ey40gzw 211 13 SARS SARS NNP cord-337137-0ey40gzw 211 14 ) ) -RRB- cord-337137-0ey40gzw 211 15 : : : cord-337137-0ey40gzw 211 16 a a DT cord-337137-0ey40gzw 211 17 study study NN cord-337137-0ey40gzw 211 18 of of IN cord-337137-0ey40gzw 211 19 8 8 CD cord-337137-0ey40gzw 211 20 autopsy autopsy JJ cord-337137-0ey40gzw 211 21 cases case NNS cord-337137-0ey40gzw 211 22 from from IN cord-337137-0ey40gzw 211 23 Singapore Singapore NNP cord-337137-0ey40gzw 211 24 Clinicopathology Clinicopathology NNP cord-337137-0ey40gzw 211 25 of of IN cord-337137-0ey40gzw 211 26 severe severe JJ cord-337137-0ey40gzw 211 27 acute acute JJ cord-337137-0ey40gzw 211 28 respiratory respiratory JJ cord-337137-0ey40gzw 211 29 syndrome syndrome NN cord-337137-0ey40gzw 211 30 : : : cord-337137-0ey40gzw 211 31 an an DT cord-337137-0ey40gzw 211 32 autopsy autopsy JJ cord-337137-0ey40gzw 211 33 case case NN cord-337137-0ey40gzw 211 34 report report VB cord-337137-0ey40gzw 211 35 Pulmonary pulmonary JJ cord-337137-0ey40gzw 211 36 pathology pathology NN cord-337137-0ey40gzw 211 37 of of IN cord-337137-0ey40gzw 211 38 severe severe JJ cord-337137-0ey40gzw 211 39 acute acute JJ cord-337137-0ey40gzw 211 40 respiratory respiratory JJ cord-337137-0ey40gzw 211 41 syndrome syndrome NN cord-337137-0ey40gzw 211 42 in in IN cord-337137-0ey40gzw 211 43 Toronto Toronto NNP cord-337137-0ey40gzw 212 1 A a DT cord-337137-0ey40gzw 212 2 clinicopathological clinicopathological JJ cord-337137-0ey40gzw 212 3 study study NN cord-337137-0ey40gzw 212 4 of of IN cord-337137-0ey40gzw 212 5 three three CD cord-337137-0ey40gzw 212 6 cases case NNS cord-337137-0ey40gzw 212 7 of of IN cord-337137-0ey40gzw 212 8 severe severe JJ cord-337137-0ey40gzw 212 9 acute acute JJ cord-337137-0ey40gzw 212 10 respiratory respiratory JJ cord-337137-0ey40gzw 212 11 syndrome syndrome NN cord-337137-0ey40gzw 212 12 ( ( -LRB- cord-337137-0ey40gzw 212 13 SARS SARS NNP cord-337137-0ey40gzw 212 14 ) ) -RRB- cord-337137-0ey40gzw 213 1 Lung lung NN cord-337137-0ey40gzw 213 2 pathology pathology NN cord-337137-0ey40gzw 213 3 of of IN cord-337137-0ey40gzw 213 4 fatal fatal JJ cord-337137-0ey40gzw 213 5 severe severe JJ cord-337137-0ey40gzw 213 6 acute acute JJ cord-337137-0ey40gzw 213 7 respiratory respiratory JJ cord-337137-0ey40gzw 213 8 syndrome syndrome NN cord-337137-0ey40gzw 213 9 Pulmonary pulmonary JJ cord-337137-0ey40gzw 213 10 pathological pathological JJ cord-337137-0ey40gzw 213 11 features feature NNS cord-337137-0ey40gzw 213 12 in in IN cord-337137-0ey40gzw 213 13 coronavirus coronavirus NN cord-337137-0ey40gzw 213 14 associated associate VBN cord-337137-0ey40gzw 213 15 severe severe JJ cord-337137-0ey40gzw 213 16 acute acute JJ cord-337137-0ey40gzw 213 17 respiratory respiratory JJ cord-337137-0ey40gzw 213 18 syndrome syndrome NN cord-337137-0ey40gzw 213 19 ( ( -LRB- cord-337137-0ey40gzw 213 20 SARS SARS NNP cord-337137-0ey40gzw 213 21 ) ) -RRB- cord-337137-0ey40gzw 213 22 Tissue tissue NN cord-337137-0ey40gzw 213 23 and and CC cord-337137-0ey40gzw 213 24 cellular cellular JJ cord-337137-0ey40gzw 213 25 tropism tropism NN cord-337137-0ey40gzw 213 26 of of IN cord-337137-0ey40gzw 213 27 the the DT cord-337137-0ey40gzw 213 28 coronavirus coronavirus NN cord-337137-0ey40gzw 213 29 associated associate VBN cord-337137-0ey40gzw 213 30 with with IN cord-337137-0ey40gzw 213 31 severe severe JJ cord-337137-0ey40gzw 213 32 acute acute JJ cord-337137-0ey40gzw 213 33 respiratory respiratory JJ cord-337137-0ey40gzw 213 34 syndrome syndrome NN cord-337137-0ey40gzw 213 35 : : : cord-337137-0ey40gzw 213 36 an an DT cord-337137-0ey40gzw 213 37 in in IN cord-337137-0ey40gzw 213 38 - - HYPH cord-337137-0ey40gzw 213 39 situ situ NN cord-337137-0ey40gzw 213 40 hybridization hybridization NN cord-337137-0ey40gzw 213 41 study study NN cord-337137-0ey40gzw 213 42 of of IN cord-337137-0ey40gzw 213 43 fatal fatal JJ cord-337137-0ey40gzw 213 44 cases case NNS cord-337137-0ey40gzw 214 1 Coronaviral Coronaviral NNP cord-337137-0ey40gzw 214 2 hypothetical hypothetical JJ cord-337137-0ey40gzw 214 3 and and CC cord-337137-0ey40gzw 214 4 structural structural JJ cord-337137-0ey40gzw 214 5 proteins protein NNS cord-337137-0ey40gzw 214 6 were be VBD cord-337137-0ey40gzw 214 7 found find VBN cord-337137-0ey40gzw 214 8 in in IN cord-337137-0ey40gzw 214 9 the the DT cord-337137-0ey40gzw 214 10 intestinal intestinal JJ cord-337137-0ey40gzw 214 11 surface surface NN cord-337137-0ey40gzw 214 12 enterocytes enterocyte NNS cord-337137-0ey40gzw 214 13 and and CC cord-337137-0ey40gzw 214 14 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 214 15 of of IN cord-337137-0ey40gzw 214 16 severe severe JJ cord-337137-0ey40gzw 214 17 acute acute JJ cord-337137-0ey40gzw 214 18 respiratory respiratory JJ cord-337137-0ey40gzw 214 19 syndrome syndrome NN cord-337137-0ey40gzw 214 20 ( ( -LRB- cord-337137-0ey40gzw 214 21 SARS SARS NNP cord-337137-0ey40gzw 214 22 ) ) -RRB- cord-337137-0ey40gzw 214 23 Analysis Analysis NNP cord-337137-0ey40gzw 214 24 of of IN cord-337137-0ey40gzw 214 25 deaths death NNS cord-337137-0ey40gzw 214 26 during during IN cord-337137-0ey40gzw 214 27 the the DT cord-337137-0ey40gzw 214 28 severe severe JJ cord-337137-0ey40gzw 214 29 acute acute JJ cord-337137-0ey40gzw 214 30 respiratory respiratory JJ cord-337137-0ey40gzw 214 31 syndrome syndrome NN cord-337137-0ey40gzw 214 32 ( ( -LRB- cord-337137-0ey40gzw 214 33 SARS SARS NNP cord-337137-0ey40gzw 214 34 ) ) -RRB- cord-337137-0ey40gzw 214 35 epidemic epidemic NN cord-337137-0ey40gzw 214 36 in in IN cord-337137-0ey40gzw 214 37 Singapore Singapore NNP cord-337137-0ey40gzw 214 38 : : : cord-337137-0ey40gzw 214 39 challenges challenge NNS cord-337137-0ey40gzw 214 40 in in IN cord-337137-0ey40gzw 214 41 determining determine VBG cord-337137-0ey40gzw 214 42 a a DT cord-337137-0ey40gzw 214 43 SARS SARS NNP cord-337137-0ey40gzw 214 44 diagnosis diagnosis NN cord-337137-0ey40gzw 214 45 Detection detection NN cord-337137-0ey40gzw 214 46 of of IN cord-337137-0ey40gzw 214 47 severe severe JJ cord-337137-0ey40gzw 214 48 acute acute JJ cord-337137-0ey40gzw 214 49 respiratory respiratory JJ cord-337137-0ey40gzw 214 50 syndrome syndrome NN cord-337137-0ey40gzw 214 51 - - HYPH cord-337137-0ey40gzw 214 52 associated associate VBN cord-337137-0ey40gzw 214 53 coronavirus coronavirus NN cord-337137-0ey40gzw 214 54 in in IN cord-337137-0ey40gzw 214 55 pneumocytes pneumocyte NNS cord-337137-0ey40gzw 214 56 of of IN cord-337137-0ey40gzw 214 57 the the DT cord-337137-0ey40gzw 214 58 lung lung NN cord-337137-0ey40gzw 214 59 SARS SARS NNP cord-337137-0ey40gzw 214 60 coronavirus coronavirus NN cord-337137-0ey40gzw 214 61 - - HYPH cord-337137-0ey40gzw 214 62 infected infect VBN cord-337137-0ey40gzw 214 63 cells cell NNS cord-337137-0ey40gzw 214 64 in in IN cord-337137-0ey40gzw 214 65 lung lung NN cord-337137-0ey40gzw 214 66 detected detect VBN cord-337137-0ey40gzw 214 67 by by IN cord-337137-0ey40gzw 214 68 new new JJ cord-337137-0ey40gzw 214 69 in in IN cord-337137-0ey40gzw 214 70 situ situ JJ cord-337137-0ey40gzw 214 71 hybridization hybridization NN cord-337137-0ey40gzw 214 72 technique technique NN cord-337137-0ey40gzw 214 73 Immunohistochemical Immunohistochemical NNP cord-337137-0ey40gzw 214 74 , , , cord-337137-0ey40gzw 214 75 in in IN cord-337137-0ey40gzw 214 76 situ situ NN cord-337137-0ey40gzw 214 77 hybridization hybridization NN cord-337137-0ey40gzw 214 78 , , , cord-337137-0ey40gzw 214 79 and and CC cord-337137-0ey40gzw 214 80 ultrastructural ultrastructural JJ cord-337137-0ey40gzw 214 81 localization localization NN cord-337137-0ey40gzw 214 82 of of IN cord-337137-0ey40gzw 214 83 SARS SARS NNP cord-337137-0ey40gzw 214 84 - - HYPH cord-337137-0ey40gzw 214 85 associated associate VBN cord-337137-0ey40gzw 214 86 coronavirus coronavirus NN cord-337137-0ey40gzw 214 87 in in IN cord-337137-0ey40gzw 214 88 lung lung NN cord-337137-0ey40gzw 214 89 of of IN cord-337137-0ey40gzw 214 90 a a DT cord-337137-0ey40gzw 214 91 fatal fatal JJ cord-337137-0ey40gzw 214 92 case case NN cord-337137-0ey40gzw 214 93 of of IN cord-337137-0ey40gzw 214 94 severe severe JJ cord-337137-0ey40gzw 214 95 acute acute JJ cord-337137-0ey40gzw 214 96 respiratory respiratory JJ cord-337137-0ey40gzw 214 97 syndrome syndrome NN cord-337137-0ey40gzw 214 98 in in IN cord-337137-0ey40gzw 214 99 Taiwan Taiwan NNP cord-337137-0ey40gzw 214 100 Myopathic Myopathic NNP cord-337137-0ey40gzw 214 101 changes change NNS cord-337137-0ey40gzw 214 102 associated associate VBN cord-337137-0ey40gzw 214 103 with with IN cord-337137-0ey40gzw 214 104 severe severe JJ cord-337137-0ey40gzw 214 105 acute acute JJ cord-337137-0ey40gzw 214 106 respiratory respiratory JJ cord-337137-0ey40gzw 214 107 syndrome syndrome NN cord-337137-0ey40gzw 214 108 : : : cord-337137-0ey40gzw 214 109 a a DT cord-337137-0ey40gzw 214 110 postmortem postmortem JJ cord-337137-0ey40gzw 214 111 case case NN cord-337137-0ey40gzw 214 112 series series NN cord-337137-0ey40gzw 214 113 SARS SARS NNP cord-337137-0ey40gzw 214 114 - - HYPH cord-337137-0ey40gzw 214 115 associated associate VBN cord-337137-0ey40gzw 214 116 viral viral JJ cord-337137-0ey40gzw 214 117 hepatitis hepatitis NN cord-337137-0ey40gzw 214 118 caused cause VBN cord-337137-0ey40gzw 214 119 by by IN cord-337137-0ey40gzw 214 120 a a DT cord-337137-0ey40gzw 214 121 novel novel JJ cord-337137-0ey40gzw 214 122 coronavirus coronavirus NN cord-337137-0ey40gzw 214 123 : : : cord-337137-0ey40gzw 214 124 report report NN cord-337137-0ey40gzw 214 125 of of IN cord-337137-0ey40gzw 214 126 three three CD cord-337137-0ey40gzw 214 127 cases case NNS cord-337137-0ey40gzw 214 128 Koch Koch NNP cord-337137-0ey40gzw 214 129 's 's POS cord-337137-0ey40gzw 214 130 postulates postulate NNS cord-337137-0ey40gzw 214 131 fulfilled fulfil VBD cord-337137-0ey40gzw 214 132 for for IN cord-337137-0ey40gzw 214 133 SARS SARS NNP cord-337137-0ey40gzw 214 134 virus virus NN cord-337137-0ey40gzw 214 135 Newly newly RB cord-337137-0ey40gzw 214 136 discovered discover VBD cord-337137-0ey40gzw 214 137 coronavirus coronavirus NN cord-337137-0ey40gzw 214 138 as as IN cord-337137-0ey40gzw 214 139 the the DT cord-337137-0ey40gzw 214 140 primary primary JJ cord-337137-0ey40gzw 214 141 cause cause NN cord-337137-0ey40gzw 214 142 of of IN cord-337137-0ey40gzw 214 143 severe severe JJ cord-337137-0ey40gzw 214 144 acute acute JJ cord-337137-0ey40gzw 214 145 respiratory respiratory JJ cord-337137-0ey40gzw 214 146 syndrome syndrome NN cord-337137-0ey40gzw 214 147 Macaque Macaque NNP cord-337137-0ey40gzw 214 148 model model NN cord-337137-0ey40gzw 214 149 for for IN cord-337137-0ey40gzw 214 150 severe severe JJ cord-337137-0ey40gzw 214 151 acute acute JJ cord-337137-0ey40gzw 214 152 respiratory respiratory JJ cord-337137-0ey40gzw 214 153 syndrome syndrome NN cord-337137-0ey40gzw 214 154 An an DT cord-337137-0ey40gzw 214 155 animal animal NN cord-337137-0ey40gzw 214 156 model model NN cord-337137-0ey40gzw 214 157 of of IN cord-337137-0ey40gzw 214 158 SARS SARS NNP cord-337137-0ey40gzw 214 159 produced produce VBN cord-337137-0ey40gzw 214 160 by by IN cord-337137-0ey40gzw 214 161 infection infection NN cord-337137-0ey40gzw 214 162 of of IN cord-337137-0ey40gzw 214 163 Macaca Macaca NNP cord-337137-0ey40gzw 214 164 mulatta mulatta NN cord-337137-0ey40gzw 214 165 with with IN cord-337137-0ey40gzw 214 166 SARS SARS NNP cord-337137-0ey40gzw 214 167 coronavirus coronavirus NN cord-337137-0ey40gzw 214 168 World World NNP cord-337137-0ey40gzw 214 169 Health Health NNP cord-337137-0ey40gzw 214 170 Organization Organization NNP cord-337137-0ey40gzw 214 171 Virology Virology NNP cord-337137-0ey40gzw 214 172 : : : cord-337137-0ey40gzw 215 1 SARS SARS NNP cord-337137-0ey40gzw 215 2 virus virus NN cord-337137-0ey40gzw 215 3 infection infection NN cord-337137-0ey40gzw 215 4 of of IN cord-337137-0ey40gzw 215 5 cats cat NNS cord-337137-0ey40gzw 215 6 and and CC cord-337137-0ey40gzw 215 7 ferrets ferret NNS cord-337137-0ey40gzw 216 1 Severe severe JJ cord-337137-0ey40gzw 216 2 acute acute JJ cord-337137-0ey40gzw 216 3 respiratory respiratory JJ cord-337137-0ey40gzw 216 4 syndrome syndrome NN cord-337137-0ey40gzw 216 5 coronavirus coronavirus NN cord-337137-0ey40gzw 216 6 - - HYPH cord-337137-0ey40gzw 216 7 like like JJ cord-337137-0ey40gzw 216 8 virus virus NN cord-337137-0ey40gzw 216 9 in in IN cord-337137-0ey40gzw 216 10 Chinese chinese JJ cord-337137-0ey40gzw 216 11 horseshoe horseshoe NN cord-337137-0ey40gzw 216 12 bats bat NNS cord-337137-0ey40gzw 216 13 Efficient efficient JJ cord-337137-0ey40gzw 216 14 replication replication NN cord-337137-0ey40gzw 216 15 of of IN cord-337137-0ey40gzw 216 16 severe severe JJ cord-337137-0ey40gzw 216 17 acute acute JJ cord-337137-0ey40gzw 216 18 respiratory respiratory JJ cord-337137-0ey40gzw 216 19 syndrome syndrome NN cord-337137-0ey40gzw 216 20 coronavirus coronavirus NN cord-337137-0ey40gzw 216 21 in in IN cord-337137-0ey40gzw 216 22 mouse mouse NN cord-337137-0ey40gzw 216 23 cells cell NNS cord-337137-0ey40gzw 216 24 is be VBZ cord-337137-0ey40gzw 216 25 limited limit VBN cord-337137-0ey40gzw 216 26 by by IN cord-337137-0ey40gzw 216 27 murine murine JJ cord-337137-0ey40gzw 216 28 angiotensin angiotensin NN cord-337137-0ey40gzw 216 29 - - HYPH cord-337137-0ey40gzw 216 30 converting convert VBG cord-337137-0ey40gzw 216 31 enzyme enzyme NN cord-337137-0ey40gzw 217 1 2 2 LS cord-337137-0ey40gzw 217 2 Angiotensin angiotensin NN cord-337137-0ey40gzw 217 3 - - HYPH cord-337137-0ey40gzw 217 4 converting convert VBG cord-337137-0ey40gzw 217 5 enzyme enzyme NN cord-337137-0ey40gzw 217 6 2 2 CD cord-337137-0ey40gzw 217 7 is be VBZ cord-337137-0ey40gzw 217 8 a a DT cord-337137-0ey40gzw 217 9 functional functional JJ cord-337137-0ey40gzw 217 10 receptor receptor NN cord-337137-0ey40gzw 217 11 for for IN cord-337137-0ey40gzw 217 12 the the DT cord-337137-0ey40gzw 217 13 SARS SARS NNP cord-337137-0ey40gzw 217 14 coronavirus coronavirus NN cord-337137-0ey40gzw 218 1 A a DT cord-337137-0ey40gzw 218 2 193-amino 193-amino CD cord-337137-0ey40gzw 218 3 acid acid NN cord-337137-0ey40gzw 218 4 fragment fragment NN cord-337137-0ey40gzw 218 5 of of IN cord-337137-0ey40gzw 218 6 the the DT cord-337137-0ey40gzw 218 7 SARS SARS NNP cord-337137-0ey40gzw 218 8 coronavirus coronavirus NN cord-337137-0ey40gzw 218 9 S S NNP cord-337137-0ey40gzw 218 10 protein protein NN cord-337137-0ey40gzw 218 11 efficiently efficiently RB cord-337137-0ey40gzw 218 12 binds bind VBZ cord-337137-0ey40gzw 218 13 angiotensin angiotensin NN cord-337137-0ey40gzw 218 14 - - HYPH cord-337137-0ey40gzw 218 15 converting convert VBG cord-337137-0ey40gzw 218 16 enzyme enzyme NN cord-337137-0ey40gzw 218 17 2 2 CD cord-337137-0ey40gzw 218 18 Dimitrov Dimitrov NNP cord-337137-0ey40gzw 218 19 DS DS NNP cord-337137-0ey40gzw 218 20 . . . cord-337137-0ey40gzw 219 1 The the DT cord-337137-0ey40gzw 219 2 SARS SARS NNP cord-337137-0ey40gzw 219 3 - - HYPH cord-337137-0ey40gzw 219 4 CoV CoV NNP cord-337137-0ey40gzw 219 5 S S NNP cord-337137-0ey40gzw 219 6 glycoprotein glycoprotein NN cord-337137-0ey40gzw 219 7 : : : cord-337137-0ey40gzw 219 8 expression expression NN cord-337137-0ey40gzw 219 9 and and CC cord-337137-0ey40gzw 219 10 functional functional JJ cord-337137-0ey40gzw 219 11 characterization characterization NN cord-337137-0ey40gzw 219 12 A a DT cord-337137-0ey40gzw 219 13 model model NN cord-337137-0ey40gzw 219 14 of of IN cord-337137-0ey40gzw 219 15 the the DT cord-337137-0ey40gzw 219 16 ACE2 ACE2 NNP cord-337137-0ey40gzw 219 17 structure structure NN cord-337137-0ey40gzw 219 18 and and CC cord-337137-0ey40gzw 219 19 function function NN cord-337137-0ey40gzw 219 20 as as IN cord-337137-0ey40gzw 219 21 a a DT cord-337137-0ey40gzw 219 22 SARS SARS NNP cord-337137-0ey40gzw 219 23 - - HYPH cord-337137-0ey40gzw 219 24 CoV CoV NNP cord-337137-0ey40gzw 219 25 receptor receptor NN cord-337137-0ey40gzw 219 26 Susceptibility Susceptibility NNP cord-337137-0ey40gzw 219 27 to to IN cord-337137-0ey40gzw 219 28 SARS SARS NNP cord-337137-0ey40gzw 219 29 coronavirus coronavirus NN cord-337137-0ey40gzw 219 30 S S NNP cord-337137-0ey40gzw 219 31 proteindriven proteindriven NN cord-337137-0ey40gzw 219 32 infection infection NN cord-337137-0ey40gzw 219 33 correlates correlate VBZ cord-337137-0ey40gzw 219 34 with with IN cord-337137-0ey40gzw 219 35 expression expression NN cord-337137-0ey40gzw 219 36 of of IN cord-337137-0ey40gzw 219 37 angiotensin angiotensin NN cord-337137-0ey40gzw 219 38 converting convert VBG cord-337137-0ey40gzw 219 39 enzyme enzyme NN cord-337137-0ey40gzw 219 40 2 2 CD cord-337137-0ey40gzw 219 41 and and CC cord-337137-0ey40gzw 219 42 infection infection NN cord-337137-0ey40gzw 219 43 can can MD cord-337137-0ey40gzw 219 44 be be VB cord-337137-0ey40gzw 219 45 blocked block VBN cord-337137-0ey40gzw 219 46 by by IN cord-337137-0ey40gzw 219 47 soluble soluble JJ cord-337137-0ey40gzw 219 48 receptor receptor NN cord-337137-0ey40gzw 219 49 Retroviruses retrovirus NNS cord-337137-0ey40gzw 219 50 pseudotyped pseudotyped NNS cord-337137-0ey40gzw 219 51 with with IN cord-337137-0ey40gzw 219 52 the the DT cord-337137-0ey40gzw 219 53 severe severe JJ cord-337137-0ey40gzw 219 54 acute acute JJ cord-337137-0ey40gzw 219 55 respiratory respiratory JJ cord-337137-0ey40gzw 219 56 syndrome syndrome NN cord-337137-0ey40gzw 219 57 coronavirus coronavirus NN cord-337137-0ey40gzw 219 58 spike spike NN cord-337137-0ey40gzw 219 59 protein protein NN cord-337137-0ey40gzw 219 60 efficiently efficiently RB cord-337137-0ey40gzw 219 61 infect infect VBP cord-337137-0ey40gzw 219 62 cells cell NNS cord-337137-0ey40gzw 219 63 expressing express VBG cord-337137-0ey40gzw 219 64 angiotensin angiotensin NN cord-337137-0ey40gzw 219 65 - - HYPH cord-337137-0ey40gzw 219 66 converting convert VBG cord-337137-0ey40gzw 219 67 enzyme enzyme NN cord-337137-0ey40gzw 219 68 2 2 CD cord-337137-0ey40gzw 219 69 Highly highly RB cord-337137-0ey40gzw 219 70 infectious infectious JJ cord-337137-0ey40gzw 219 71 SARS SARS NNP cord-337137-0ey40gzw 219 72 - - HYPH cord-337137-0ey40gzw 219 73 CoV CoV NNP cord-337137-0ey40gzw 219 74 pseudotyped pseudotyped NNP cord-337137-0ey40gzw 219 75 virus virus NN cord-337137-0ey40gzw 219 76 reveals reveal VBZ cord-337137-0ey40gzw 219 77 the the DT cord-337137-0ey40gzw 219 78 cell cell NN cord-337137-0ey40gzw 219 79 tropism tropism NN cord-337137-0ey40gzw 219 80 and and CC cord-337137-0ey40gzw 219 81 its -PRON- PRP$ cord-337137-0ey40gzw 219 82 correlation correlation NN cord-337137-0ey40gzw 219 83 with with IN cord-337137-0ey40gzw 219 84 receptor receptor NN cord-337137-0ey40gzw 219 85 expression expression NN cord-337137-0ey40gzw 219 86 Tissue tissue NN cord-337137-0ey40gzw 219 87 distribution distribution NN cord-337137-0ey40gzw 219 88 of of IN cord-337137-0ey40gzw 219 89 ACE2 ACE2 NNP cord-337137-0ey40gzw 219 90 protein protein NN cord-337137-0ey40gzw 219 91 , , , cord-337137-0ey40gzw 219 92 the the DT cord-337137-0ey40gzw 219 93 functional functional JJ cord-337137-0ey40gzw 219 94 receptor receptor NN cord-337137-0ey40gzw 219 95 for for IN cord-337137-0ey40gzw 219 96 SARS SARS NNP cord-337137-0ey40gzw 219 97 coronavirus coronavirus NN cord-337137-0ey40gzw 219 98 . . . cord-337137-0ey40gzw 220 1 A a DT cord-337137-0ey40gzw 220 2 first first JJ cord-337137-0ey40gzw 220 3 step step NN cord-337137-0ey40gzw 220 4 in in IN cord-337137-0ey40gzw 220 5 understanding understand VBG cord-337137-0ey40gzw 220 6 SARS SARS NNP cord-337137-0ey40gzw 220 7 pathogenesis pathogenesis NN cord-337137-0ey40gzw 220 8 Persistent persistent JJ cord-337137-0ey40gzw 220 9 infection infection NN cord-337137-0ey40gzw 220 10 of of IN cord-337137-0ey40gzw 220 11 SARS SARS NNP cord-337137-0ey40gzw 220 12 coronavirus coronavirus NN cord-337137-0ey40gzw 220 13 in in IN cord-337137-0ey40gzw 220 14 colonic colonic JJ cord-337137-0ey40gzw 220 15 cells cell NNS cord-337137-0ey40gzw 220 16 in in IN cord-337137-0ey40gzw 220 17 vitro vitro FW cord-337137-0ey40gzw 220 18 Angiotensin angiotensin NN cord-337137-0ey40gzw 220 19 - - HYPH cord-337137-0ey40gzw 220 20 converting convert VBG cord-337137-0ey40gzw 220 21 enzyme enzyme NN cord-337137-0ey40gzw 220 22 2 2 CD cord-337137-0ey40gzw 220 23 protects protect VBZ cord-337137-0ey40gzw 220 24 from from IN cord-337137-0ey40gzw 220 25 severe severe JJ cord-337137-0ey40gzw 220 26 acute acute JJ cord-337137-0ey40gzw 220 27 lung lung NN cord-337137-0ey40gzw 220 28 failure failure NN cord-337137-0ey40gzw 220 29 ACE2 ACE2 NNP cord-337137-0ey40gzw 220 30 , , , cord-337137-0ey40gzw 220 31 a a DT cord-337137-0ey40gzw 220 32 new new JJ cord-337137-0ey40gzw 220 33 regulator regulator NN cord-337137-0ey40gzw 220 34 of of IN cord-337137-0ey40gzw 220 35 the the DT cord-337137-0ey40gzw 220 36 renin renin NN cord-337137-0ey40gzw 220 37 - - HYPH cord-337137-0ey40gzw 220 38 angiotensin angiotensin NN cord-337137-0ey40gzw 220 39 system system NN cord-337137-0ey40gzw 221 1 A a DT cord-337137-0ey40gzw 221 2 crucial crucial JJ cord-337137-0ey40gzw 221 3 role role NN cord-337137-0ey40gzw 221 4 of of IN cord-337137-0ey40gzw 221 5 angiotensin angiotensin NN cord-337137-0ey40gzw 221 6 converting convert VBG cord-337137-0ey40gzw 221 7 enzyme enzyme NN cord-337137-0ey40gzw 221 8 2 2 CD cord-337137-0ey40gzw 221 9 ( ( -LRB- cord-337137-0ey40gzw 221 10 ACE2 ACE2 NNP cord-337137-0ey40gzw 221 11 ) ) -RRB- cord-337137-0ey40gzw 221 12 in in IN cord-337137-0ey40gzw 221 13 SARS SARS NNP cord-337137-0ey40gzw 221 14 coronavirus coronavirus NN cord-337137-0ey40gzw 221 15 - - HYPH cord-337137-0ey40gzw 221 16 induced induce VBN cord-337137-0ey40gzw 221 17 lung lung NN cord-337137-0ey40gzw 221 18 injury injury NN cord-337137-0ey40gzw 221 19 Human human JJ cord-337137-0ey40gzw 221 20 coronavirus coronavirus NN cord-337137-0ey40gzw 221 21 NL63 NL63 NNP cord-337137-0ey40gzw 221 22 employs employ VBZ cord-337137-0ey40gzw 221 23 the the DT cord-337137-0ey40gzw 221 24 severe severe JJ cord-337137-0ey40gzw 221 25 acute acute JJ cord-337137-0ey40gzw 221 26 respiratory respiratory JJ cord-337137-0ey40gzw 221 27 syndrome syndrome NN cord-337137-0ey40gzw 221 28 coronavirus coronavirus NN cord-337137-0ey40gzw 221 29 receptor receptor NN cord-337137-0ey40gzw 221 30 for for IN cord-337137-0ey40gzw 221 31 cellular cellular JJ cord-337137-0ey40gzw 221 32 entry entry NN cord-337137-0ey40gzw 221 33 ACE1 ace1 CD cord-337137-0ey40gzw 221 34 polymorphism polymorphism NN cord-337137-0ey40gzw 221 35 and and CC cord-337137-0ey40gzw 221 36 progression progression NN cord-337137-0ey40gzw 221 37 of of IN cord-337137-0ey40gzw 221 38 SARS SARS NNP cord-337137-0ey40gzw 221 39 Absence Absence NNP cord-337137-0ey40gzw 221 40 of of IN cord-337137-0ey40gzw 221 41 association association NN cord-337137-0ey40gzw 221 42 between between IN cord-337137-0ey40gzw 221 43 angiotensin angiotensin NNP cord-337137-0ey40gzw 221 44 converting convert VBG cord-337137-0ey40gzw 221 45 enzyme enzyme NN cord-337137-0ey40gzw 221 46 polymorphism polymorphism NN cord-337137-0ey40gzw 221 47 and and CC cord-337137-0ey40gzw 221 48 development development NN cord-337137-0ey40gzw 221 49 of of IN cord-337137-0ey40gzw 221 50 adult adult JJ cord-337137-0ey40gzw 221 51 respiratory respiratory JJ cord-337137-0ey40gzw 221 52 distress distress NN cord-337137-0ey40gzw 221 53 syndrome syndrome NN cord-337137-0ey40gzw 221 54 in in IN cord-337137-0ey40gzw 221 55 patients patient NNS cord-337137-0ey40gzw 221 56 with with IN cord-337137-0ey40gzw 221 57 severe severe JJ cord-337137-0ey40gzw 221 58 acute acute JJ cord-337137-0ey40gzw 221 59 respiratory respiratory JJ cord-337137-0ey40gzw 221 60 syndrome syndrome NN cord-337137-0ey40gzw 221 61 : : : cord-337137-0ey40gzw 221 62 a a DT cord-337137-0ey40gzw 221 63 case case NN cord-337137-0ey40gzw 221 64 control control NN cord-337137-0ey40gzw 221 65 study study NN cord-337137-0ey40gzw 221 66 ACE2 ACE2 NNP cord-337137-0ey40gzw 221 67 gene gene NN cord-337137-0ey40gzw 221 68 polymorphisms polymorphism NNS cord-337137-0ey40gzw 221 69 do do VBP cord-337137-0ey40gzw 221 70 not not RB cord-337137-0ey40gzw 221 71 affect affect VB cord-337137-0ey40gzw 221 72 outcome outcome NN cord-337137-0ey40gzw 221 73 of of IN cord-337137-0ey40gzw 221 74 severe severe JJ cord-337137-0ey40gzw 221 75 acute acute JJ cord-337137-0ey40gzw 221 76 respiratory respiratory JJ cord-337137-0ey40gzw 221 77 syndrome syndrome NN cord-337137-0ey40gzw 221 78 pH ph NN cord-337137-0ey40gzw 221 79 - - HYPH cord-337137-0ey40gzw 221 80 dependent dependent JJ cord-337137-0ey40gzw 221 81 entry entry NN cord-337137-0ey40gzw 221 82 of of IN cord-337137-0ey40gzw 221 83 severe severe JJ cord-337137-0ey40gzw 221 84 acute acute JJ cord-337137-0ey40gzw 221 85 respiratory respiratory JJ cord-337137-0ey40gzw 221 86 syndrome syndrome NN cord-337137-0ey40gzw 221 87 coronavirus coronavirus NN cord-337137-0ey40gzw 221 88 is be VBZ cord-337137-0ey40gzw 221 89 mediated mediate VBN cord-337137-0ey40gzw 221 90 by by IN cord-337137-0ey40gzw 221 91 the the DT cord-337137-0ey40gzw 221 92 spike spike NN cord-337137-0ey40gzw 221 93 glycoprotein glycoprotein NN cord-337137-0ey40gzw 221 94 and and CC cord-337137-0ey40gzw 221 95 enhanced enhance VBN cord-337137-0ey40gzw 221 96 by by IN cord-337137-0ey40gzw 221 97 dendritic dendritic JJ cord-337137-0ey40gzw 221 98 cell cell NN cord-337137-0ey40gzw 221 99 transfer transfer NN cord-337137-0ey40gzw 221 100 through through IN cord-337137-0ey40gzw 221 101 DC DC NNP cord-337137-0ey40gzw 221 102 - - HYPH cord-337137-0ey40gzw 221 103 SIGN sign NN cord-337137-0ey40gzw 221 104 CD209L cd209l NN cord-337137-0ey40gzw 221 105 ( ( -LRB- cord-337137-0ey40gzw 221 106 L l NN cord-337137-0ey40gzw 221 107 - - HYPH cord-337137-0ey40gzw 221 108 SIGN SIGN NNP cord-337137-0ey40gzw 221 109 ) ) -RRB- cord-337137-0ey40gzw 221 110 is be VBZ cord-337137-0ey40gzw 221 111 a a DT cord-337137-0ey40gzw 221 112 receptor receptor NN cord-337137-0ey40gzw 221 113 for for IN cord-337137-0ey40gzw 221 114 severe severe JJ cord-337137-0ey40gzw 221 115 acute acute JJ cord-337137-0ey40gzw 221 116 respiratory respiratory JJ cord-337137-0ey40gzw 221 117 syndrome syndrome NN cord-337137-0ey40gzw 221 118 coronavirus coronavirus NN cord-337137-0ey40gzw 221 119 LSECtin lsectin NN cord-337137-0ey40gzw 221 120 interacts interact VBZ cord-337137-0ey40gzw 221 121 with with IN cord-337137-0ey40gzw 221 122 filovirus filovirus NN cord-337137-0ey40gzw 221 123 glycoproteins glycoprotein NNS cord-337137-0ey40gzw 221 124 and and CC cord-337137-0ey40gzw 221 125 the the DT cord-337137-0ey40gzw 221 126 spike spike NN cord-337137-0ey40gzw 221 127 protein protein NN cord-337137-0ey40gzw 221 128 of of IN cord-337137-0ey40gzw 221 129 SARS SARS NNP cord-337137-0ey40gzw 221 130 coronavirus coronavirus NN cord-337137-0ey40gzw 221 131 DC DC NNP cord-337137-0ey40gzw 221 132 - - HYPH cord-337137-0ey40gzw 221 133 SIGN SIGN NNP cord-337137-0ey40gzw 221 134 and and CC cord-337137-0ey40gzw 221 135 DC DC NNP cord-337137-0ey40gzw 221 136 - - HYPH cord-337137-0ey40gzw 221 137 SIGNR SIGNR NNP cord-337137-0ey40gzw 222 1 interact interact VB cord-337137-0ey40gzw 222 2 with with IN cord-337137-0ey40gzw 222 3 the the DT cord-337137-0ey40gzw 222 4 glycoprotein glycoprotein NN cord-337137-0ey40gzw 222 5 of of IN cord-337137-0ey40gzw 222 6 Marburg Marburg NNP cord-337137-0ey40gzw 222 7 virus virus NN cord-337137-0ey40gzw 222 8 and and CC cord-337137-0ey40gzw 222 9 the the DT cord-337137-0ey40gzw 222 10 S S NNP cord-337137-0ey40gzw 222 11 protein protein NN cord-337137-0ey40gzw 222 12 of of IN cord-337137-0ey40gzw 222 13 severe severe JJ cord-337137-0ey40gzw 222 14 acute acute JJ cord-337137-0ey40gzw 222 15 respiratory respiratory JJ cord-337137-0ey40gzw 222 16 syndrome syndrome NN cord-337137-0ey40gzw 222 17 coronavirus coronavirus NN cord-337137-0ey40gzw 222 18 Chemokine chemokine JJ cord-337137-0ey40gzw 222 19 upregulation upregulation NN cord-337137-0ey40gzw 222 20 in in IN cord-337137-0ey40gzw 222 21 SARS SARS NNP cord-337137-0ey40gzw 222 22 coronavirus coronavirus NN cord-337137-0ey40gzw 222 23 infected infect VBD cord-337137-0ey40gzw 222 24 human human JJ cord-337137-0ey40gzw 222 25 monocyte monocyte NNP cord-337137-0ey40gzw 222 26 derived derive VBN cord-337137-0ey40gzw 222 27 dendritic dendritic JJ cord-337137-0ey40gzw 222 28 cells cell NNS cord-337137-0ey40gzw 222 29 DC DC NNP cord-337137-0ey40gzw 222 30 - - HYPH cord-337137-0ey40gzw 222 31 SIGN sign NN cord-337137-0ey40gzw 222 32 : : : cord-337137-0ey40gzw 222 33 escape escape VB cord-337137-0ey40gzw 222 34 mechanism mechanism NN cord-337137-0ey40gzw 222 35 for for IN cord-337137-0ey40gzw 222 36 pathogens pathogen NNS cord-337137-0ey40gzw 222 37 Molecular molecular JJ cord-337137-0ey40gzw 222 38 epidemiology epidemiology NN cord-337137-0ey40gzw 222 39 of of IN cord-337137-0ey40gzw 222 40 SARS SARS NNP cord-337137-0ey40gzw 222 41 -from -from NNP cord-337137-0ey40gzw 223 1 Amoy Amoy NNP cord-337137-0ey40gzw 223 2 Gardens Gardens NNPS cord-337137-0ey40gzw 223 3 to to IN cord-337137-0ey40gzw 223 4 Taiwan Taiwan NNP cord-337137-0ey40gzw 223 5 Molecular Molecular NNP cord-337137-0ey40gzw 223 6 evolution evolution NN cord-337137-0ey40gzw 223 7 of of IN cord-337137-0ey40gzw 223 8 the the DT cord-337137-0ey40gzw 223 9 SARS SARS NNP cord-337137-0ey40gzw 223 10 coronavirus coronavirus NN cord-337137-0ey40gzw 223 11 during during IN cord-337137-0ey40gzw 223 12 the the DT cord-337137-0ey40gzw 223 13 course course NN cord-337137-0ey40gzw 223 14 of of IN cord-337137-0ey40gzw 223 15 the the DT cord-337137-0ey40gzw 223 16 SARS SARS NNP cord-337137-0ey40gzw 223 17 epidemic epidemic NN cord-337137-0ey40gzw 223 18 in in IN cord-337137-0ey40gzw 223 19 China China NNP cord-337137-0ey40gzw 224 1 The the DT cord-337137-0ey40gzw 224 2 Genome Genome NNP cord-337137-0ey40gzw 224 3 sequence sequence NN cord-337137-0ey40gzw 224 4 of of IN cord-337137-0ey40gzw 224 5 the the DT cord-337137-0ey40gzw 224 6 SARSassociated sarsassociated JJ cord-337137-0ey40gzw 224 7 coronavirus coronavirus NN cord-337137-0ey40gzw 224 8 Characterization characterization NN cord-337137-0ey40gzw 224 9 of of IN cord-337137-0ey40gzw 224 10 a a DT cord-337137-0ey40gzw 224 11 novel novel JJ cord-337137-0ey40gzw 224 12 coronavirus coronavirus NN cord-337137-0ey40gzw 224 13 associated associate VBN cord-337137-0ey40gzw 224 14 with with IN cord-337137-0ey40gzw 224 15 severe severe JJ cord-337137-0ey40gzw 224 16 acute acute JJ cord-337137-0ey40gzw 224 17 respiratory respiratory JJ cord-337137-0ey40gzw 224 18 syndrome syndrome NN cord-337137-0ey40gzw 224 19 A a DT cord-337137-0ey40gzw 224 20 novel novel JJ cord-337137-0ey40gzw 224 21 severe severe JJ cord-337137-0ey40gzw 224 22 acute acute JJ cord-337137-0ey40gzw 224 23 respiratory respiratory JJ cord-337137-0ey40gzw 224 24 syndrome syndrome NN cord-337137-0ey40gzw 224 25 coronavirus coronavirus NN cord-337137-0ey40gzw 224 26 protein protein NN cord-337137-0ey40gzw 224 27 , , , cord-337137-0ey40gzw 224 28 U274 u274 CD cord-337137-0ey40gzw 224 29 , , , cord-337137-0ey40gzw 224 30 is be VBZ cord-337137-0ey40gzw 224 31 transported transport VBN cord-337137-0ey40gzw 224 32 to to IN cord-337137-0ey40gzw 224 33 the the DT cord-337137-0ey40gzw 224 34 cell cell NN cord-337137-0ey40gzw 224 35 surface surface NN cord-337137-0ey40gzw 224 36 and and CC cord-337137-0ey40gzw 224 37 undergoes undergo VBZ cord-337137-0ey40gzw 224 38 endocytosis endocytosis NN cord-337137-0ey40gzw 224 39 Characterization characterization NN cord-337137-0ey40gzw 224 40 of of IN cord-337137-0ey40gzw 224 41 a a DT cord-337137-0ey40gzw 224 42 unique unique JJ cord-337137-0ey40gzw 224 43 group group NN cord-337137-0ey40gzw 224 44 - - HYPH cord-337137-0ey40gzw 224 45 specific specific JJ cord-337137-0ey40gzw 224 46 protein protein NN cord-337137-0ey40gzw 224 47 ( ( -LRB- cord-337137-0ey40gzw 224 48 U122 U122 NNP cord-337137-0ey40gzw 224 49 ) ) -RRB- cord-337137-0ey40gzw 224 50 of of IN cord-337137-0ey40gzw 224 51 the the DT cord-337137-0ey40gzw 224 52 severe severe JJ cord-337137-0ey40gzw 224 53 acute acute JJ cord-337137-0ey40gzw 224 54 respiratory respiratory JJ cord-337137-0ey40gzw 224 55 syndrome syndrome NN cord-337137-0ey40gzw 224 56 coronavirus coronavirus NN cord-337137-0ey40gzw 224 57 Specific specific JJ cord-337137-0ey40gzw 224 58 epitopes epitope NNS cord-337137-0ey40gzw 224 59 of of IN cord-337137-0ey40gzw 224 60 the the DT cord-337137-0ey40gzw 224 61 structural structural JJ cord-337137-0ey40gzw 224 62 and and CC cord-337137-0ey40gzw 224 63 hypothetical hypothetical JJ cord-337137-0ey40gzw 224 64 proteins protein NNS cord-337137-0ey40gzw 224 65 elicit elicit VBP cord-337137-0ey40gzw 224 66 variable variable JJ cord-337137-0ey40gzw 224 67 humoral humoral JJ cord-337137-0ey40gzw 224 68 responses response NNS cord-337137-0ey40gzw 224 69 in in IN cord-337137-0ey40gzw 224 70 SARS SARS NNP cord-337137-0ey40gzw 224 71 patients patient NNS cord-337137-0ey40gzw 225 1 The the DT cord-337137-0ey40gzw 225 2 3a 3a CD cord-337137-0ey40gzw 225 3 protein protein NN cord-337137-0ey40gzw 225 4 of of IN cord-337137-0ey40gzw 225 5 severe severe JJ cord-337137-0ey40gzw 225 6 acute acute JJ cord-337137-0ey40gzw 225 7 respiratory respiratory JJ cord-337137-0ey40gzw 225 8 syndromeassociated syndromeassociate VBN cord-337137-0ey40gzw 225 9 coronavirus coronavirus NN cord-337137-0ey40gzw 225 10 induces induce VBZ cord-337137-0ey40gzw 225 11 apoptosis apoptosis NN cord-337137-0ey40gzw 225 12 in in IN cord-337137-0ey40gzw 225 13 Vero Vero NNP cord-337137-0ey40gzw 225 14 E6 E6 NNP cord-337137-0ey40gzw 225 15 cells cell NNS cord-337137-0ey40gzw 226 1 The the DT cord-337137-0ey40gzw 226 2 severe severe JJ cord-337137-0ey40gzw 226 3 acute acute JJ cord-337137-0ey40gzw 226 4 respiratory respiratory JJ cord-337137-0ey40gzw 226 5 syndrome syndrome NN cord-337137-0ey40gzw 226 6 coronavirus coronavirus NN cord-337137-0ey40gzw 226 7 3a 3a NNP cord-337137-0ey40gzw 226 8 is be VBZ cord-337137-0ey40gzw 226 9 a a DT cord-337137-0ey40gzw 226 10 novel novel JJ cord-337137-0ey40gzw 226 11 structural structural JJ cord-337137-0ey40gzw 226 12 protein protein NN cord-337137-0ey40gzw 226 13 Severe severe JJ cord-337137-0ey40gzw 226 14 acute acute JJ cord-337137-0ey40gzw 226 15 respiratory respiratory JJ cord-337137-0ey40gzw 226 16 syndrome syndrome NN cord-337137-0ey40gzw 226 17 coronavirus coronavirus NN cord-337137-0ey40gzw 226 18 3a 3a NNP cord-337137-0ey40gzw 226 19 protein protein NN cord-337137-0ey40gzw 226 20 is be VBZ cord-337137-0ey40gzw 226 21 a a DT cord-337137-0ey40gzw 226 22 viral viral JJ cord-337137-0ey40gzw 226 23 structural structural JJ cord-337137-0ey40gzw 226 24 protein protein NN cord-337137-0ey40gzw 226 25 Identification identification NN cord-337137-0ey40gzw 226 26 of of IN cord-337137-0ey40gzw 226 27 a a DT cord-337137-0ey40gzw 226 28 novel novel JJ cord-337137-0ey40gzw 226 29 protein protein NN cord-337137-0ey40gzw 226 30 3a 3a NNP cord-337137-0ey40gzw 226 31 from from IN cord-337137-0ey40gzw 226 32 severe severe JJ cord-337137-0ey40gzw 226 33 acute acute JJ cord-337137-0ey40gzw 226 34 respiratory respiratory JJ cord-337137-0ey40gzw 226 35 syndrome syndrome NN cord-337137-0ey40gzw 226 36 coronavirus coronavirus NN cord-337137-0ey40gzw 227 1 The the DT cord-337137-0ey40gzw 227 2 severe severe JJ cord-337137-0ey40gzw 227 3 acute acute JJ cord-337137-0ey40gzw 227 4 respiratory respiratory JJ cord-337137-0ey40gzw 227 5 syndrome syndrome NN cord-337137-0ey40gzw 227 6 coronavirus coronavirus NN cord-337137-0ey40gzw 227 7 3a 3a CD cord-337137-0ey40gzw 227 8 protein protein NN cord-337137-0ey40gzw 227 9 up up RB cord-337137-0ey40gzw 227 10 - - HYPH cord-337137-0ey40gzw 227 11 regulates regulate VBZ cord-337137-0ey40gzw 227 12 expression expression NN cord-337137-0ey40gzw 227 13 of of IN cord-337137-0ey40gzw 227 14 fibrinogen fibrinogen NN cord-337137-0ey40gzw 227 15 in in IN cord-337137-0ey40gzw 227 16 lung lung NN cord-337137-0ey40gzw 227 17 epithelial epithelial NN cord-337137-0ey40gzw 227 18 cells cell NNS cord-337137-0ey40gzw 227 19 Overexpression Overexpression NNP cord-337137-0ey40gzw 227 20 of of IN cord-337137-0ey40gzw 227 21 7a 7a NN cord-337137-0ey40gzw 227 22 , , , cord-337137-0ey40gzw 227 23 a a DT cord-337137-0ey40gzw 227 24 protein protein NN cord-337137-0ey40gzw 227 25 specifically specifically RB cord-337137-0ey40gzw 227 26 encoded encode VBN cord-337137-0ey40gzw 227 27 by by IN cord-337137-0ey40gzw 227 28 the the DT cord-337137-0ey40gzw 227 29 severe severe JJ cord-337137-0ey40gzw 227 30 acute acute JJ cord-337137-0ey40gzw 227 31 respiratory respiratory JJ cord-337137-0ey40gzw 227 32 syndrome syndrome NN cord-337137-0ey40gzw 227 33 coronavirus coronavirus NN cord-337137-0ey40gzw 227 34 , , , cord-337137-0ey40gzw 227 35 induces induce VBZ cord-337137-0ey40gzw 227 36 apoptosis apoptosis NN cord-337137-0ey40gzw 227 37 via via IN cord-337137-0ey40gzw 227 38 a a DT cord-337137-0ey40gzw 227 39 caspase caspase NN cord-337137-0ey40gzw 227 40 - - HYPH cord-337137-0ey40gzw 227 41 dependent dependent JJ cord-337137-0ey40gzw 227 42 pathway pathway NN cord-337137-0ey40gzw 227 43 The the DT cord-337137-0ey40gzw 227 44 pulmonary pulmonary JJ cord-337137-0ey40gzw 227 45 physician physician NN cord-337137-0ey40gzw 227 46 in in IN cord-337137-0ey40gzw 227 47 critical critical JJ cord-337137-0ey40gzw 227 48 care care NN cord-337137-0ey40gzw 228 1 * * NFP cord-337137-0ey40gzw 228 2 6 6 CD cord-337137-0ey40gzw 228 3 : : : cord-337137-0ey40gzw 229 1 the the DT cord-337137-0ey40gzw 229 2 pathogenesis pathogenesis NN cord-337137-0ey40gzw 229 3 of of IN cord-337137-0ey40gzw 229 4 ALI ALI NNP cord-337137-0ey40gzw 229 5 / / SYM cord-337137-0ey40gzw 229 6 ARDS ARDS NNP cord-337137-0ey40gzw 229 7 Polymorphonuclear Polymorphonuclear NNP cord-337137-0ey40gzw 229 8 neutrophil neutrophil NN cord-337137-0ey40gzw 229 9 activation activation NN cord-337137-0ey40gzw 229 10 during during IN cord-337137-0ey40gzw 229 11 the the DT cord-337137-0ey40gzw 229 12 acute acute JJ cord-337137-0ey40gzw 229 13 respiratory respiratory JJ cord-337137-0ey40gzw 229 14 distress distress NN cord-337137-0ey40gzw 229 15 syndrome syndrome NN cord-337137-0ey40gzw 229 16 Pathology Pathology NNP cord-337137-0ey40gzw 229 17 of of IN cord-337137-0ey40gzw 229 18 fatal fatal JJ cord-337137-0ey40gzw 229 19 human human JJ cord-337137-0ey40gzw 229 20 infection infection NN cord-337137-0ey40gzw 229 21 associated associate VBN cord-337137-0ey40gzw 229 22 with with IN cord-337137-0ey40gzw 229 23 avian avian JJ cord-337137-0ey40gzw 229 24 influenza influenza NN cord-337137-0ey40gzw 229 25 A a DT cord-337137-0ey40gzw 229 26 H5N1 H5N1 NNP cord-337137-0ey40gzw 229 27 virus virus NN cord-337137-0ey40gzw 229 28 Infections infection NNS cord-337137-0ey40gzw 229 29 and and CC cord-337137-0ey40gzw 229 30 the the DT cord-337137-0ey40gzw 229 31 inflammatory inflammatory JJ cord-337137-0ey40gzw 229 32 response response NN cord-337137-0ey40gzw 229 33 in in IN cord-337137-0ey40gzw 229 34 acute acute JJ cord-337137-0ey40gzw 229 35 respiratory respiratory JJ cord-337137-0ey40gzw 229 36 distress distress NN cord-337137-0ey40gzw 229 37 syndrome syndrome NN cord-337137-0ey40gzw 229 38 Anti Anti NNP cord-337137-0ey40gzw 229 39 - - NNP cord-337137-0ey40gzw 229 40 SARS SARS NNP cord-337137-0ey40gzw 229 41 - - HYPH cord-337137-0ey40gzw 229 42 CoV CoV NNP cord-337137-0ey40gzw 229 43 IgG IgG NNP cord-337137-0ey40gzw 229 44 response response NN cord-337137-0ey40gzw 229 45 in in IN cord-337137-0ey40gzw 229 46 relation relation NN cord-337137-0ey40gzw 229 47 to to IN cord-337137-0ey40gzw 229 48 disease disease NN cord-337137-0ey40gzw 229 49 severity severity NN cord-337137-0ey40gzw 229 50 of of IN cord-337137-0ey40gzw 229 51 severe severe JJ cord-337137-0ey40gzw 229 52 acute acute JJ cord-337137-0ey40gzw 229 53 respiratory respiratory JJ cord-337137-0ey40gzw 229 54 syndrome syndrome NN cord-337137-0ey40gzw 229 55 Autoantibodies Autoantibodies NNP cord-337137-0ey40gzw 229 56 against against IN cord-337137-0ey40gzw 229 57 human human JJ cord-337137-0ey40gzw 229 58 epithelial epithelial JJ cord-337137-0ey40gzw 229 59 cells cell NNS cord-337137-0ey40gzw 229 60 and and CC cord-337137-0ey40gzw 229 61 endothelial endothelial JJ cord-337137-0ey40gzw 229 62 cells cell NNS cord-337137-0ey40gzw 229 63 after after IN cord-337137-0ey40gzw 229 64 severe severe JJ cord-337137-0ey40gzw 229 65 acute acute JJ cord-337137-0ey40gzw 229 66 respiratory respiratory JJ cord-337137-0ey40gzw 229 67 syndrome syndrome NN cord-337137-0ey40gzw 229 68 ( ( -LRB- cord-337137-0ey40gzw 229 69 SARS)-associated sars)-associated CD cord-337137-0ey40gzw 229 70 coronavirus coronavirus NN cord-337137-0ey40gzw 229 71 infection infection NN cord-337137-0ey40gzw 229 72 Chemokines Chemokines NNPS cord-337137-0ey40gzw 229 73 in in IN cord-337137-0ey40gzw 229 74 acute acute JJ cord-337137-0ey40gzw 229 75 respiratory respiratory JJ cord-337137-0ey40gzw 229 76 distress distress NN cord-337137-0ey40gzw 229 77 syndrome syndrome NN cord-337137-0ey40gzw 230 1 A a DT cord-337137-0ey40gzw 230 2 chemokine chemokine NN cord-337137-0ey40gzw 230 3 - - HYPH cord-337137-0ey40gzw 230 4 tocytokine tocytokine NN cord-337137-0ey40gzw 230 5 - - HYPH cord-337137-0ey40gzw 230 6 to to IN cord-337137-0ey40gzw 230 7 - - HYPH cord-337137-0ey40gzw 230 8 chemokine chemokine NN cord-337137-0ey40gzw 230 9 cascade cascade NN cord-337137-0ey40gzw 230 10 critical critical JJ cord-337137-0ey40gzw 230 11 in in IN cord-337137-0ey40gzw 230 12 antiviral antiviral JJ cord-337137-0ey40gzw 230 13 defense defense NN cord-337137-0ey40gzw 230 14 Chemokine Chemokine NNP cord-337137-0ey40gzw 230 15 regulation regulation NN cord-337137-0ey40gzw 230 16 of of IN cord-337137-0ey40gzw 230 17 inflammation inflammation NN cord-337137-0ey40gzw 230 18 during during IN cord-337137-0ey40gzw 230 19 acute acute JJ cord-337137-0ey40gzw 230 20 viral viral JJ cord-337137-0ey40gzw 230 21 infection infection NN cord-337137-0ey40gzw 230 22 Plasma Plasma VBD cord-337137-0ey40gzw 230 23 inflammatory inflammatory JJ cord-337137-0ey40gzw 230 24 cytokines cytokine NNS cord-337137-0ey40gzw 230 25 and and CC cord-337137-0ey40gzw 230 26 chemokines chemokine NNS cord-337137-0ey40gzw 230 27 in in IN cord-337137-0ey40gzw 230 28 severe severe JJ cord-337137-0ey40gzw 230 29 acute acute JJ cord-337137-0ey40gzw 230 30 respiratory respiratory JJ cord-337137-0ey40gzw 230 31 syndrome syndrome NN cord-337137-0ey40gzw 230 32 Dynamic dynamic JJ cord-337137-0ey40gzw 230 33 changes change NNS cord-337137-0ey40gzw 230 34 in in IN cord-337137-0ey40gzw 230 35 clinical clinical JJ cord-337137-0ey40gzw 230 36 features feature NNS cord-337137-0ey40gzw 230 37 and and CC cord-337137-0ey40gzw 230 38 cytokine cytokine NN cord-337137-0ey40gzw 230 39 / / SYM cord-337137-0ey40gzw 230 40 chemokine chemokine NN cord-337137-0ey40gzw 230 41 responses response NNS cord-337137-0ey40gzw 230 42 in in IN cord-337137-0ey40gzw 230 43 SARS SARS NNP cord-337137-0ey40gzw 230 44 patients patient NNS cord-337137-0ey40gzw 230 45 treated treat VBN cord-337137-0ey40gzw 230 46 with with IN cord-337137-0ey40gzw 230 47 interferon interferon NN cord-337137-0ey40gzw 230 48 alfacon-1 alfacon-1 NNP cord-337137-0ey40gzw 230 49 plus plus CC cord-337137-0ey40gzw 230 50 corticosteroids corticosteroid NNS cord-337137-0ey40gzw 230 51 Characterization characterization NN cord-337137-0ey40gzw 230 52 of of IN cord-337137-0ey40gzw 230 53 cytokine cytokine NN cord-337137-0ey40gzw 230 54 / / SYM cord-337137-0ey40gzw 230 55 chemokine chemokine NN cord-337137-0ey40gzw 230 56 profiles profile NNS cord-337137-0ey40gzw 230 57 of of IN cord-337137-0ey40gzw 230 58 severe severe JJ cord-337137-0ey40gzw 230 59 acute acute JJ cord-337137-0ey40gzw 230 60 respiratory respiratory JJ cord-337137-0ey40gzw 230 61 syndrome syndrome NN cord-337137-0ey40gzw 231 1 An an DT cord-337137-0ey40gzw 231 2 interferon interferon NN cord-337137-0ey40gzw 231 3 - - HYPH cord-337137-0ey40gzw 231 4 gamma gamma NN cord-337137-0ey40gzw 231 5 - - HYPH cord-337137-0ey40gzw 231 6 related relate VBN cord-337137-0ey40gzw 231 7 cytokine cytokine NN cord-337137-0ey40gzw 231 8 storm storm NN cord-337137-0ey40gzw 231 9 in in IN cord-337137-0ey40gzw 231 10 SARS SARS NNP cord-337137-0ey40gzw 231 11 patients patient NNS cord-337137-0ey40gzw 231 12 Early early RB cord-337137-0ey40gzw 231 13 enhanced enhanced JJ cord-337137-0ey40gzw 231 14 expression expression NN cord-337137-0ey40gzw 231 15 of of IN cord-337137-0ey40gzw 231 16 IP-10 IP-10 NNP cord-337137-0ey40gzw 231 17 ( ( -LRB- cord-337137-0ey40gzw 231 18 CXCL-10 CXCL-10 NNP cord-337137-0ey40gzw 231 19 ) ) -RRB- cord-337137-0ey40gzw 231 20 and and CC cord-337137-0ey40gzw 231 21 other other JJ cord-337137-0ey40gzw 231 22 chemokines chemokine NNS cord-337137-0ey40gzw 231 23 predicts predict VBZ cord-337137-0ey40gzw 231 24 adverse adverse JJ cord-337137-0ey40gzw 231 25 outcome outcome NN cord-337137-0ey40gzw 231 26 in in IN cord-337137-0ey40gzw 231 27 severe severe JJ cord-337137-0ey40gzw 231 28 acute acute JJ cord-337137-0ey40gzw 231 29 respiratory respiratory JJ cord-337137-0ey40gzw 231 30 syndrome syndrome NN cord-337137-0ey40gzw 231 31 ( ( -LRB- cord-337137-0ey40gzw 231 32 SARS SARS NNP cord-337137-0ey40gzw 231 33 ) ) -RRB- cord-337137-0ey40gzw 231 34 Mechanisms Mechanisms NNPS cord-337137-0ey40gzw 231 35 of of IN cord-337137-0ey40gzw 231 36 host host NN cord-337137-0ey40gzw 231 37 defense defense NN cord-337137-0ey40gzw 231 38 following follow VBG cord-337137-0ey40gzw 231 39 severe severe JJ cord-337137-0ey40gzw 231 40 acute acute JJ cord-337137-0ey40gzw 231 41 respiratory respiratory JJ cord-337137-0ey40gzw 231 42 syndromecoronavirus syndromecoronavirus NNP cord-337137-0ey40gzw 231 43 ( ( -LRB- cord-337137-0ey40gzw 231 44 SARS SARS NNP cord-337137-0ey40gzw 231 45 - - HYPH cord-337137-0ey40gzw 231 46 CoV CoV NNP cord-337137-0ey40gzw 231 47 ) ) -RRB- cord-337137-0ey40gzw 231 48 pulmonary pulmonary JJ cord-337137-0ey40gzw 231 49 infection infection NN cord-337137-0ey40gzw 231 50 of of IN cord-337137-0ey40gzw 231 51 mice mouse NNS cord-337137-0ey40gzw 231 52 CXC CXC NNP cord-337137-0ey40gzw 231 53 chemokines chemokine NNS cord-337137-0ey40gzw 231 54 IP-10 IP-10 NNP cord-337137-0ey40gzw 231 55 and and CC cord-337137-0ey40gzw 231 56 mig mig NNP cord-337137-0ey40gzw 231 57 expression expression NN cord-337137-0ey40gzw 231 58 and and CC cord-337137-0ey40gzw 231 59 direct direct JJ cord-337137-0ey40gzw 231 60 migration migration NN cord-337137-0ey40gzw 231 61 of of IN cord-337137-0ey40gzw 231 62 pulmonary pulmonary NN cord-337137-0ey40gzw 231 63 CD8+/CXCR3 cd8+/cxcr3 NN cord-337137-0ey40gzw 232 1 + + CC cord-337137-0ey40gzw 233 1 T T NNP cord-337137-0ey40gzw 233 2 cells cell NNS cord-337137-0ey40gzw 233 3 in in IN cord-337137-0ey40gzw 233 4 the the DT cord-337137-0ey40gzw 233 5 lungs lung NNS cord-337137-0ey40gzw 233 6 of of IN cord-337137-0ey40gzw 233 7 patients patient NNS cord-337137-0ey40gzw 233 8 with with IN cord-337137-0ey40gzw 233 9 HIV HIV NNP cord-337137-0ey40gzw 233 10 infection infection NN cord-337137-0ey40gzw 233 11 and and CC cord-337137-0ey40gzw 233 12 T t NN cord-337137-0ey40gzw 233 13 - - HYPH cord-337137-0ey40gzw 233 14 cell cell NN cord-337137-0ey40gzw 233 15 alveolitis alveolitis NN cord-337137-0ey40gzw 233 16 Role role NN cord-337137-0ey40gzw 233 17 of of IN cord-337137-0ey40gzw 233 18 CXCL9 CXCL9 NNP cord-337137-0ey40gzw 233 19 / / SYM cord-337137-0ey40gzw 233 20 CXCR3 cxcr3 NN cord-337137-0ey40gzw 233 21 chemokine chemokine NN cord-337137-0ey40gzw 233 22 biology biology NN cord-337137-0ey40gzw 233 23 during during IN cord-337137-0ey40gzw 233 24 pathogenesis pathogenesis NN cord-337137-0ey40gzw 233 25 of of IN cord-337137-0ey40gzw 233 26 acute acute JJ cord-337137-0ey40gzw 233 27 lung lung NN cord-337137-0ey40gzw 233 28 allograft allograft NN cord-337137-0ey40gzw 233 29 rejection rejection NN cord-337137-0ey40gzw 233 30 Chemokine Chemokine NNP cord-337137-0ey40gzw 233 31 response response NN cord-337137-0ey40gzw 233 32 in in IN cord-337137-0ey40gzw 233 33 children child NNS cord-337137-0ey40gzw 233 34 with with IN cord-337137-0ey40gzw 233 35 SARS SARS NNP cord-337137-0ey40gzw 233 36 Genetic genetic JJ cord-337137-0ey40gzw 233 37 polymorphisms polymorphism NNS cord-337137-0ey40gzw 233 38 associated associate VBN cord-337137-0ey40gzw 233 39 with with IN cord-337137-0ey40gzw 233 40 susceptibility susceptibility NN cord-337137-0ey40gzw 233 41 and and CC cord-337137-0ey40gzw 233 42 outcome outcome NN cord-337137-0ey40gzw 233 43 in in IN cord-337137-0ey40gzw 233 44 ARDS ARDS NNP cord-337137-0ey40gzw 233 45 Genetic genetic JJ cord-337137-0ey40gzw 233 46 susceptibility susceptibility NN cord-337137-0ey40gzw 233 47 to to IN cord-337137-0ey40gzw 233 48 acute acute JJ cord-337137-0ey40gzw 233 49 lung lung NN cord-337137-0ey40gzw 233 50 injury injury NN cord-337137-0ey40gzw 234 1 Plasminogen plasminogen NN cord-337137-0ey40gzw 234 2 - - HYPH cord-337137-0ey40gzw 234 3 activator activator NN cord-337137-0ey40gzw 234 4 - - HYPH cord-337137-0ey40gzw 234 5 inhibitor-1 inhibitor-1 NNP cord-337137-0ey40gzw 234 6 4G/5 4g/5 CD cord-337137-0ey40gzw 234 7 G g NN cord-337137-0ey40gzw 234 8 promoter promoter NN cord-337137-0ey40gzw 234 9 polymorphism polymorphism NN cord-337137-0ey40gzw 234 10 and and CC cord-337137-0ey40gzw 234 11 prognosis prognosis NN cord-337137-0ey40gzw 234 12 of of IN cord-337137-0ey40gzw 234 13 severely severely RB cord-337137-0ey40gzw 234 14 injured injure VBN cord-337137-0ey40gzw 234 15 patients patient NNS cord-337137-0ey40gzw 234 16 Angiotensin Angiotensin NNP cord-337137-0ey40gzw 234 17 converting convert VBG cord-337137-0ey40gzw 234 18 enzyme enzyme NN cord-337137-0ey40gzw 234 19 insertion insertion NN cord-337137-0ey40gzw 234 20 / / SYM cord-337137-0ey40gzw 234 21 deletion deletion NN cord-337137-0ey40gzw 234 22 polymorphism polymorphism NN cord-337137-0ey40gzw 234 23 is be VBZ cord-337137-0ey40gzw 234 24 associated associate VBN cord-337137-0ey40gzw 234 25 with with IN cord-337137-0ey40gzw 234 26 susceptibility susceptibility NN cord-337137-0ey40gzw 234 27 and and CC cord-337137-0ey40gzw 234 28 outcome outcome NN cord-337137-0ey40gzw 234 29 in in IN cord-337137-0ey40gzw 234 30 acute acute JJ cord-337137-0ey40gzw 234 31 respiratory respiratory JJ cord-337137-0ey40gzw 234 32 distress distress NN cord-337137-0ey40gzw 234 33 syndrome syndrome NN cord-337137-0ey40gzw 234 34 Association Association NNP cord-337137-0ey40gzw 234 35 between between IN cord-337137-0ey40gzw 234 36 a a DT cord-337137-0ey40gzw 234 37 genomic genomic JJ cord-337137-0ey40gzw 234 38 polymorphism polymorphism NN cord-337137-0ey40gzw 234 39 within within IN cord-337137-0ey40gzw 234 40 the the DT cord-337137-0ey40gzw 234 41 CD14 CD14 NNP cord-337137-0ey40gzw 234 42 locus locus NN cord-337137-0ey40gzw 234 43 and and CC cord-337137-0ey40gzw 234 44 septic septic JJ cord-337137-0ey40gzw 234 45 shock shock NN cord-337137-0ey40gzw 234 46 susceptibility susceptibility NN cord-337137-0ey40gzw 234 47 and and CC cord-337137-0ey40gzw 234 48 mortality mortality NN cord-337137-0ey40gzw 234 49 rate rate NN cord-337137-0ey40gzw 234 50 Polymorphisms polymorphism NNS cord-337137-0ey40gzw 234 51 of of IN cord-337137-0ey40gzw 234 52 human human JJ cord-337137-0ey40gzw 234 53 SP sp NN cord-337137-0ey40gzw 234 54 - - HYPH cord-337137-0ey40gzw 234 55 A A NNP cord-337137-0ey40gzw 234 56 , , , cord-337137-0ey40gzw 234 57 SP SP NNP cord-337137-0ey40gzw 234 58 - - HYPH cord-337137-0ey40gzw 234 59 B B NNP cord-337137-0ey40gzw 234 60 , , , cord-337137-0ey40gzw 234 61 and and CC cord-337137-0ey40gzw 234 62 SP SP NNP cord-337137-0ey40gzw 234 63 - - HYPH cord-337137-0ey40gzw 234 64 D D NNP cord-337137-0ey40gzw 234 65 genes gene NNS cord-337137-0ey40gzw 234 66 : : : cord-337137-0ey40gzw 234 67 association association NN cord-337137-0ey40gzw 234 68 of of IN cord-337137-0ey40gzw 234 69 SP SP NNP cord-337137-0ey40gzw 234 70 - - HYPH cord-337137-0ey40gzw 234 71 B B NNP cord-337137-0ey40gzw 234 72 Thr131Ile Thr131Ile NNP cord-337137-0ey40gzw 234 73 with with IN cord-337137-0ey40gzw 234 74 ARDS ARDS NNP cord-337137-0ey40gzw 234 75 Common common JJ cord-337137-0ey40gzw 234 76 features feature NNS cord-337137-0ey40gzw 234 77 in in IN cord-337137-0ey40gzw 234 78 the the DT cord-337137-0ey40gzw 234 79 onset onset NN cord-337137-0ey40gzw 234 80 of of IN cord-337137-0ey40gzw 234 81 ARDS ARDS NNP cord-337137-0ey40gzw 234 82 after after IN cord-337137-0ey40gzw 234 83 administration administration NN cord-337137-0ey40gzw 234 84 of of IN cord-337137-0ey40gzw 234 85 granulocyte granulocyte NNP cord-337137-0ey40gzw 234 86 colony colony NN cord-337137-0ey40gzw 234 87 - - HYPH cord-337137-0ey40gzw 234 88 stimulating stimulate VBG cord-337137-0ey40gzw 234 89 factor factor NN cord-337137-0ey40gzw 234 90 Identification identification NN cord-337137-0ey40gzw 234 91 of of IN cord-337137-0ey40gzw 234 92 an an DT cord-337137-0ey40gzw 234 93 alternative alternative JJ cord-337137-0ey40gzw 234 94 5 5 CD cord-337137-0ey40gzw 234 95 -untranslated -untranslated JJ cord-337137-0ey40gzw 234 96 exon exon NN cord-337137-0ey40gzw 234 97 and and CC cord-337137-0ey40gzw 234 98 new new JJ cord-337137-0ey40gzw 234 99 polymorphisms polymorphism NNS cord-337137-0ey40gzw 234 100 of of IN cord-337137-0ey40gzw 234 101 angiotensin angiotensin NN cord-337137-0ey40gzw 234 102 - - HYPH cord-337137-0ey40gzw 234 103 converting convert VBG cord-337137-0ey40gzw 234 104 enzyme enzyme NN cord-337137-0ey40gzw 234 105 2 2 CD cord-337137-0ey40gzw 234 106 gene gene NN cord-337137-0ey40gzw 234 107 : : : cord-337137-0ey40gzw 234 108 lack lack NN cord-337137-0ey40gzw 234 109 of of IN cord-337137-0ey40gzw 234 110 association association NN cord-337137-0ey40gzw 234 111 with with IN cord-337137-0ey40gzw 234 112 SARS SARS NNP cord-337137-0ey40gzw 234 113 in in IN cord-337137-0ey40gzw 234 114 the the DT cord-337137-0ey40gzw 234 115 Vietnamese vietnamese JJ cord-337137-0ey40gzw 234 116 population population NN cord-337137-0ey40gzw 234 117 Association Association NNP cord-337137-0ey40gzw 234 118 of of IN cord-337137-0ey40gzw 234 119 HLA HLA NNP cord-337137-0ey40gzw 234 120 class class NN cord-337137-0ey40gzw 234 121 I -PRON- PRP cord-337137-0ey40gzw 234 122 with with IN cord-337137-0ey40gzw 234 123 severe severe JJ cord-337137-0ey40gzw 234 124 acute acute JJ cord-337137-0ey40gzw 234 125 respiratory respiratory JJ cord-337137-0ey40gzw 234 126 syndrome syndrome NN cord-337137-0ey40gzw 234 127 coronavirus coronavirus NN cord-337137-0ey40gzw 234 128 infection infection NNP cord-337137-0ey40gzw 234 129 Association Association NNP cord-337137-0ey40gzw 234 130 of of IN cord-337137-0ey40gzw 234 131 human human JJ cord-337137-0ey40gzw 234 132 - - HYPH cord-337137-0ey40gzw 234 133 leukocyte leukocyte NN cord-337137-0ey40gzw 234 134 - - HYPH cord-337137-0ey40gzw 234 135 antigen antigen NN cord-337137-0ey40gzw 234 136 class class NN cord-337137-0ey40gzw 235 1 I -PRON- PRP cord-337137-0ey40gzw 236 1 ( ( -LRB- cord-337137-0ey40gzw 236 2 B b NN cord-337137-0ey40gzw 236 3 * * NFP cord-337137-0ey40gzw 236 4 0703 0703 CD cord-337137-0ey40gzw 236 5 ) ) -RRB- cord-337137-0ey40gzw 236 6 and and CC cord-337137-0ey40gzw 236 7 class class NN cord-337137-0ey40gzw 236 8 II II NNP cord-337137-0ey40gzw 236 9 ( ( -LRB- cord-337137-0ey40gzw 236 10 DRB1 DRB1 NNP cord-337137-0ey40gzw 236 11 * * NFP cord-337137-0ey40gzw 236 12 0301 0301 CD cord-337137-0ey40gzw 236 13 ) ) -RRB- cord-337137-0ey40gzw 236 14 genotypes genotype NNS cord-337137-0ey40gzw 236 15 with with IN cord-337137-0ey40gzw 236 16 susceptibility susceptibility NN cord-337137-0ey40gzw 236 17 and and CC cord-337137-0ey40gzw 236 18 resistance resistance NN cord-337137-0ey40gzw 236 19 to to IN cord-337137-0ey40gzw 236 20 the the DT cord-337137-0ey40gzw 236 21 development development NN cord-337137-0ey40gzw 236 22 of of IN cord-337137-0ey40gzw 236 23 severe severe JJ cord-337137-0ey40gzw 236 24 acute acute JJ cord-337137-0ey40gzw 236 25 respiratory respiratory JJ cord-337137-0ey40gzw 236 26 syndrome syndrome NN