id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-027858-j8kioy8e	Lefkowitch, Jay H.	Acute Viral Hepatitis	2020-06-22		.txt	text/plain	4126	260	41	10, 11 Occasionally, mild serum liver test abnormalities and mild histological hepatitis ('bystander hepatitis') with apoptotic bodies, focal necrosis and lymphocytic inflammation are seen in systemic, non-hepatic viral infections such as pulmonary influenza and result from migration to the liver of and collateral damage by CD8 T-lymphocytes. Another form of hepatocellular damage in acute hepatitis is focal (spotty) necrosis, in which liver-cell plates are disrupted or replaced by small groups of lymphocytes and macrophages. Focal as opposed to zonal areas of confluent necrosis haphazardly distributed in relation to lobular zones are more likely to be due to causes other than acute viral hepatitis; possibilities to be considered include opportunistic infections with herpes simplex or zoster viruses and lymphoma. Extensive microvesicular change of hepatocytes, previously described in hepatitis D infection, has been seen also in severe acute hepatitis A (Fig. 6.14) .	./cache/cord-027858-j8kioy8e.txt	./txt/cord-027858-j8kioy8e.txt