id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-007585-vs5yondw	Dere, Willard H.	Acute bronchitis: Results of U.S. and European trials of antibiotic therapy	1992-06-22		.txt	text/plain	2037	122	43	Four clinical trials were conducted to compare high and low doses of loracarbef, a new oral β-lactam antibiotic, with three agents commonly used to treat acute bronchitis: amoxicillin/clavulanate, cefaclor, and amoxicillin. Results of these studies indicated that loracarbef, 400 and 200 mg twice daily, had clinical and bacteriologic efficacy against the common respiratory pathogens Streptococcus pneumoniae, Haemophilus influenzae, and Moraxella (Branhamella) catarrhalis that was comparable with that of the comparative agents. This article reviews the etiology and treatment of acute bronchitis as well as the safety and efficacy results of four clinical trials designed to compare a new fllactam antibiotic, loracarbef, with agents currently used as therapy for patients with this condition. More than 2,000 patients were enrolled in the four studies: a total of 538 received high-dose loracarbef, 561 received low-dose loracarbef, 244 received amoxiciUin/clavulanate, 159 received cefaclor, and 716 received amoxicillin [15, 16; Dere WH, unpublished data, 1991] .	./cache/cord-007585-vs5yondw.txt	./txt/cord-007585-vs5yondw.txt