id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-321985-w84wwkgi	Xing, Shihua	Simulated gastrointestinal tract metabolism and pharmacological activities of water extract of Scutellaria baicalensis roots	2014-02-27		.txt	text/plain	4481	237	44	RESULTS: Main constituents of WESB remain unchanged during the incubation with simulated gastric juice (pH=1.5) and intestinal juice (pH=6.8), whereas four flavones, baicalin, wogonoside, oroxyloside and norwogonoside were metabolized into their respective aglycons by human intestinal bacteria. In this study, the water extract of Huangqin, the root of Scutellaria baicalensis (WESB) was incubated with simulated gastric and intestinal juices, and human fecal microflora, their metabolites were identified and the in vitro anticomplementary activity was evaluated. The inhibitory activity of main compounds in Huangqin as well as their metabolites against the standard strains of methicillin-resistant Staphylococcus aureus (MRSA), methicillin sensitive Staphylococcus aureus (MSSA), Enterococcus faecalis (gram-positive bacteria), Escherichia coli, Pseudomonas aeuroginosa (gram-negative bacteria) was determined to understand the role of gastrointestinal tract conditions on pharmacological effects of Huangqin. According to the content changes as well as the chemical structure of the eight ingredients in WESB, we concluded that four flavone glycosides, baicalin, wogonoside, oroxyloside and norwogonoside were converted to their respective aglycons, i.e. baicalein, wogonin, oroxylin A and norwogonin by intestinal bacteria.	./cache/cord-321985-w84wwkgi.txt	./txt/cord-321985-w84wwkgi.txt