id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-318854-xaus3bma	Sun, Yi	Chapter 4 Bioactivity and Synthesis of Diarylheptanoids From Alpinia officinarum	2016-12-31		.txt	text/plain	5322	298	48	In this review, we discuss the antitumor-promoting, antiinflammatory, cytotoxic, antimicrobial, antiinfluenza, and antiherpes simplex-1 virus activities of diarylheptanoids isolated from galangal resulting from our own and other research groups' investigation. Compound 6 showed the strongest activity among the four diarylheptanoids (IC 50 : 10 μM), and it also inhibited the mRNA expression of tyrosinase, tyrosinase-related protein (TRP)-1 and TRP-2, as well as protein levels of microphthalmia-associated transcription factor (MITF) [52] . Compounds 2, 6, 15, 16, 47, and 48 were tested for their inhibitory effects on NO production in the LPS-activated macrophage cell line RAW 264.7 [15] . Thus, the reports cited above suggest that diarylheptanoids possess inhibitory effects against inflammatory and tumor-promoting activities. Compound 4 was also active against influenza virus with an EC 50 value of <10 μg/mL [61] , which suggests that 4 is an effective diarylheptanoid against both RSV and influenza virus in vitro.	./cache/cord-318854-xaus3bma.txt	./txt/cord-318854-xaus3bma.txt