id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-270424-8yhsjbmi	Kang, Dongwei	First discovery of novel 3-hydroxy-quinazoline-2,4(1H,3H)-diones as specific anti-vaccinia and adenovirus agents via ‘privileged scaffold’ refining approach	2016-11-01		.txt	text/plain	1902	101	44	27 In this context, in view of the above fact and to discover completely new anti-vaccinia and adenovirus agents with a novel skeleton and unique mode of action, a relatively small library of 6-(1-benzyl-1H-1,2,3-triazol-4-yl)-3-hydroxyquinazoline-2,4(1H,3H)-dione compounds (the general formula in Scheme 1) was constructed via the copper(I)-catalyzed azidealkyne cycloaddition (CuAAC) reaction 28 and the biological significance of the novel synthesized quinazolines was highlighted by evaluating them in cell culturebased antiviral high-throughput screening (HTS) assays against a broad panel of DNA viruses, retroviruses and several RNA viruses. The newly synthesized 1,2,3-triazole-linked 3-hydroxy-quinazoline-2,4 (1H,3H)-diones were performed to evaluate against their antiviral activity against a broad panel of DNA virus, including Herpes simplex virus-1 (KOS), Herpes simplex virus-2 (G), Herpes simplex virus-1 TKKOS ACVr, vaccinia virus and Adeno virus-2 (evaluated in infected human embryonic lung fibroblast (HEL) cells). In conclusion, a series of novel 1,2,3-triazole-containing 3hydroxy-quinazoline-2,4(1H,3H)-diones has been synthesized using CuAAC reaction, and was firstly identified as potent and specific vaccinia and adenovirus inhibitors in vitro.	./cache/cord-270424-8yhsjbmi.txt	./txt/cord-270424-8yhsjbmi.txt