id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-252108-04xr5xdl	Havrylyuk, Dmytro	Synthesis and biological activity evaluation of 5-pyrazoline substituted 4-thiazolidinones	2013-06-06		.txt	text/plain	3454	210	52	The screening of antitrypanosomal and antiviral activities of 5-(3-naphthalen-2-yl-5-aryl-4,5-dihydropyrazol-1-yl)-thiazolidine-2,4-diones was carried out with the promising influence of the mentioned compounds on Trypanosoma brucei, but minimal effect on SARS coronavirus and influenza types A and B viruses. The most promising compound in series of aryl-4-oxothiazolylhydrazones was shown to be very active at non-cytotoxic concentrations in in vitro assays against Trypanosoma cruzi cell cultures and exhibited potency comparable with the reference compounds (IC 50 (Y strain) ¼ 0.3 mM) [9] . Aiming at the detailed elaboration of SAR, especially the influence of the linking group of thiazolidinoneepyrazoline conjugates on the anticancer activity, 5-[2-(3,5-diaryl-4,5-dihydropyrazol-1-yl)-2oxoethylidene]-thiazolidine-2,4-diones (4ae4f) were synthesized by the method, described previously [29] . The cytotoxic and/or growth inhibitory effects of the most active selected compounds were tested in vitro against the full panel of human tumor cell lines at concentrations ranging from 10 À4 to 10 À8 M.	./cache/cord-252108-04xr5xdl.txt	./txt/cord-252108-04xr5xdl.txt