id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-011038-5t8az1hf	Mor, Satbir	Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones	2019-10-26		.txt	text/plain	5433	363	57	title: Synthesis, Type II diabetes inhibitory activity, antimicrobial evaluation and docking studies of indeno[1,2-c]pyrazol-4(1H)-ones We report a convenient and efficient synthesis of indeno[1,2-c]pyrazol-4(1H)-ones (4a‒o) by the reaction of a variety of 2-acyl-(1H)-indene-1,3(2H)-diones (1) and 2-hydrazinylbenzo[d]thiazole/2-hydrazinyl-6-substitutedbenzo[d]thiazoles (2) in the presence of glacial acetic acid in good yields. All the synthesized indeno[1,2-c]pyrazol-4(1H)-ones (4a‒o) were assayed for their in vitro Type II diabetes inhibitory activity by using Acarbose as standard drug and in vitro antimicrobial activity utilizing Streptomycin and Fluconazole as reference drugs. 2017; Huang and Huang 2019) and sulfur as heteroatoms and their biological activities herein, we report the synthesis, characterization, α-amylase and α-glucosidase inhibition, antimicrobial evaluation and docking studies of several benzothiazole tethered indeno [1,2-c] pyrazol-4(1H)ones (4a-o). In conclusion, the present study describe the synthesis and characterization of heterocyclic frameworks i.e., indeno [1,2-c] pyrazoles (4), and their biological evaluation as inhibitor of α-glucosidase and α-amylase related to Type II diabetes, and antimicrobial activity.	./cache/cord-011038-5t8az1hf.txt	./txt/cord-011038-5t8az1hf.txt