id	sid	tid	token	lemma	pos
cord-295807-68sukdb1	1	1	key	key	NN
cord-295807-68sukdb1	1	2	:	:	:
cord-295807-68sukdb1	2	1	cord-295807	cord-295807	NNP
cord-295807-68sukdb1	2	2	-	-	HYPH
cord-295807-68sukdb1	2	3	68sukdb1	68sukdb1	CD
cord-295807-68sukdb1	2	4	authors	author	NNS
cord-295807-68sukdb1	2	5	:	:	:
cord-295807-68sukdb1	2	6	Quade	Quade	NNP
cord-295807-68sukdb1	2	7	,	,	,
cord-295807-68sukdb1	2	8	Bianca	Bianca	NNP
cord-295807-68sukdb1	2	9	N.	N.	NNP
cord-295807-68sukdb1	2	10	;	;	:
cord-295807-68sukdb1	2	11	Parker	Parker	NNP
cord-295807-68sukdb1	2	12	,	,	,
cord-295807-68sukdb1	2	13	Mark	Mark	NNP
cord-295807-68sukdb1	2	14	D.	D.	NNP
cord-295807-68sukdb1	2	15	;	;	:
cord-295807-68sukdb1	3	1	Occhipinti	Occhipinti	NNP
cord-295807-68sukdb1	3	2	,	,	,
cord-295807-68sukdb1	3	3	Rossana	Rossana	NNP
cord-295807-68sukdb1	3	4	title	title	NN
cord-295807-68sukdb1	3	5	:	:	:
cord-295807-68sukdb1	4	1	The	the	DT
cord-295807-68sukdb1	4	2	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	4	3	importance	importance	NN
cord-295807-68sukdb1	4	4	of	of	IN
cord-295807-68sukdb1	4	5	acid	acid	NN
cord-295807-68sukdb1	4	6	-	-	HYPH
cord-295807-68sukdb1	4	7	base	base	NN
cord-295807-68sukdb1	4	8	balance	balance	NN
cord-295807-68sukdb1	4	9	date	date	NN
cord-295807-68sukdb1	4	10	:	:	:
cord-295807-68sukdb1	4	11	2020	2020	CD
cord-295807-68sukdb1	4	12	-	-	SYM
cord-295807-68sukdb1	4	13	10	10	CD
cord-295807-68sukdb1	4	14	-	-	HYPH
cord-295807-68sukdb1	4	15	09	09	CD
cord-295807-68sukdb1	4	16	journal	journal	NN
cord-295807-68sukdb1	4	17	:	:	:
cord-295807-68sukdb1	5	1	Biochem	Biochem	NNP
cord-295807-68sukdb1	5	2	Pharmacol	Pharmacol	NNP
cord-295807-68sukdb1	5	3	DOI	DOI	NNP
cord-295807-68sukdb1	5	4	:	:	:
cord-295807-68sukdb1	5	5	10.1016	10.1016	CD
cord-295807-68sukdb1	5	6	/	/	SYM
cord-295807-68sukdb1	5	7	j.bcp.2020.114278	j.bcp.2020.114278	NNP
cord-295807-68sukdb1	5	8	sha	sha	NNP
cord-295807-68sukdb1	5	9	:	:	:
cord-295807-68sukdb1	5	10	b405af73de04962dcb6f1dd422adddec7999c3b3	b405af73de04962dcb6f1dd422adddec7999c3b3	.
cord-295807-68sukdb1	5	11	doc_id	doc_id	CD
cord-295807-68sukdb1	5	12	:	:	:
cord-295807-68sukdb1	5	13	295807	295807	CD
cord-295807-68sukdb1	5	14	cord_uid	cord_uid	NNS
cord-295807-68sukdb1	5	15	:	:	:
cord-295807-68sukdb1	6	1	68sukdb1	68sukdb1	CD
cord-295807-68sukdb1	6	2	Baking	baking	NN
cord-295807-68sukdb1	6	3	soda	soda	NN
cord-295807-68sukdb1	6	4	and	and	CC
cord-295807-68sukdb1	6	5	vinegar	vinegar	NN
cord-295807-68sukdb1	6	6	have	have	VBP
cord-295807-68sukdb1	6	7	been	be	VBN
cord-295807-68sukdb1	6	8	used	use	VBN
cord-295807-68sukdb1	6	9	as	as	IN
cord-295807-68sukdb1	6	10	home	home	NN
cord-295807-68sukdb1	6	11	remedies	remedy	NNS
cord-295807-68sukdb1	6	12	for	for	IN
cord-295807-68sukdb1	6	13	generations	generation	NNS
cord-295807-68sukdb1	7	1	and	and	CC
cord-295807-68sukdb1	7	2	today	today	NN
cord-295807-68sukdb1	7	3	we	-PRON-	PRP
cord-295807-68sukdb1	7	4	are	be	VBP
cord-295807-68sukdb1	7	5	only	only	RB
cord-295807-68sukdb1	7	6	a	a	DT
cord-295807-68sukdb1	7	7	mouse	mouse	NN
cord-295807-68sukdb1	7	8	-	-	HYPH
cord-295807-68sukdb1	7	9	click	click	VB
cord-295807-68sukdb1	7	10	away	away	RB
cord-295807-68sukdb1	7	11	from	from	IN
cord-295807-68sukdb1	7	12	claims	claim	NNS
cord-295807-68sukdb1	7	13	that	that	IN
cord-295807-68sukdb1	7	14	baking	baking	NN
cord-295807-68sukdb1	7	15	soda	soda	NN
cord-295807-68sukdb1	7	16	,	,	,
cord-295807-68sukdb1	7	17	lemon	lemon	NN
cord-295807-68sukdb1	7	18	juice	juice	NN
cord-295807-68sukdb1	7	19	,	,	,
cord-295807-68sukdb1	7	20	and	and	CC
cord-295807-68sukdb1	7	21	apple	apple	NN
cord-295807-68sukdb1	7	22	cider	cider	NN
cord-295807-68sukdb1	7	23	vinegar	vinegar	NN
cord-295807-68sukdb1	7	24	are	be	VBP
cord-295807-68sukdb1	7	25	miracles	miracle	NNS
cord-295807-68sukdb1	7	26	cures	cure	VBZ
cord-295807-68sukdb1	7	27	for	for	IN
cord-295807-68sukdb1	7	28	everything	everything	NN
cord-295807-68sukdb1	7	29	from	from	IN
cord-295807-68sukdb1	7	30	cancer	cancer	NN
cord-295807-68sukdb1	7	31	to	to	IN
cord-295807-68sukdb1	7	32	COVID-19	COVID-19	NNP
cord-295807-68sukdb1	7	33	.	.	.
cord-295807-68sukdb1	8	1	Despite	despite	IN
cord-295807-68sukdb1	8	2	these	these	DT
cord-295807-68sukdb1	8	3	specious	specious	JJ
cord-295807-68sukdb1	8	4	claims	claim	NNS
cord-295807-68sukdb1	8	5	,	,	,
cord-295807-68sukdb1	8	6	the	the	DT
cord-295807-68sukdb1	8	7	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	8	8	value	value	NN
cord-295807-68sukdb1	8	9	of	of	IN
cord-295807-68sukdb1	8	10	controlling	control	VBG
cord-295807-68sukdb1	8	11	acid	acid	NN
cord-295807-68sukdb1	8	12	-	-	HYPH
cord-295807-68sukdb1	8	13	base	base	NN
cord-295807-68sukdb1	8	14	balance	balance	NN
cord-295807-68sukdb1	8	15	is	be	VBZ
cord-295807-68sukdb1	8	16	indisputable	indisputable	JJ
cord-295807-68sukdb1	8	17	and	and	CC
cord-295807-68sukdb1	8	18	is	be	VBZ
cord-295807-68sukdb1	8	19	the	the	DT
cord-295807-68sukdb1	8	20	basis	basis	NN
cord-295807-68sukdb1	8	21	of	of	IN
cord-295807-68sukdb1	8	22	Food	Food	NNP
cord-295807-68sukdb1	8	23	and	and	CC
cord-295807-68sukdb1	8	24	Drug	Drug	NNP
cord-295807-68sukdb1	8	25	Administration	Administration	NNP
cord-295807-68sukdb1	8	26	-	-	HYPH
cord-295807-68sukdb1	8	27	approved	approve	VBN
cord-295807-68sukdb1	8	28	treatments	treatment	NNS
cord-295807-68sukdb1	8	29	for	for	IN
cord-295807-68sukdb1	8	30	constipation	constipation	NN
cord-295807-68sukdb1	8	31	,	,	,
cord-295807-68sukdb1	8	32	epilepsy	epilepsy	NN
cord-295807-68sukdb1	8	33	,	,	,
cord-295807-68sukdb1	8	34	metabolic	metabolic	JJ
cord-295807-68sukdb1	8	35	acidosis	acidosis	NN
cord-295807-68sukdb1	8	36	,	,	,
cord-295807-68sukdb1	8	37	and	and	CC
cord-295807-68sukdb1	8	38	peptic	peptic	JJ
cord-295807-68sukdb1	8	39	ulcers	ulcer	NNS
cord-295807-68sukdb1	8	40	.	.	.
cord-295807-68sukdb1	9	1	In	in	IN
cord-295807-68sukdb1	9	2	this	this	DT
cord-295807-68sukdb1	9	3	narrative	narrative	NN
cord-295807-68sukdb1	9	4	review	review	NN
cord-295807-68sukdb1	9	5	,	,	,
cord-295807-68sukdb1	9	6	we	-PRON-	PRP
cord-295807-68sukdb1	9	7	present	present	VBP
cord-295807-68sukdb1	9	8	evidence	evidence	NN
cord-295807-68sukdb1	9	9	in	in	IN
cord-295807-68sukdb1	9	10	support	support	NN
cord-295807-68sukdb1	9	11	of	of	IN
cord-295807-68sukdb1	9	12	the	the	DT
cord-295807-68sukdb1	9	13	current	current	JJ
cord-295807-68sukdb1	9	14	and	and	CC
cord-295807-68sukdb1	9	15	potential	potential	JJ
cord-295807-68sukdb1	9	16	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	9	17	value	value	NN
cord-295807-68sukdb1	9	18	of	of	IN
cord-295807-68sukdb1	9	19	countering	counter	VBG
cord-295807-68sukdb1	9	20	local	local	JJ
cord-295807-68sukdb1	9	21	and	and	CC
cord-295807-68sukdb1	9	22	systemic	systemic	JJ
cord-295807-68sukdb1	9	23	acid	acid	NN
cord-295807-68sukdb1	9	24	-	-	HYPH
cord-295807-68sukdb1	9	25	base	base	NN
cord-295807-68sukdb1	9	26	imbalances	imbalance	NNS
cord-295807-68sukdb1	9	27	,	,	,
cord-295807-68sukdb1	9	28	several	several	JJ
cord-295807-68sukdb1	9	29	of	of	IN
cord-295807-68sukdb1	9	30	which	which	WDT
cord-295807-68sukdb1	9	31	do	do	VBP
cord-295807-68sukdb1	9	32	in	in	IN
cord-295807-68sukdb1	9	33	fact	fact	NN
cord-295807-68sukdb1	9	34	involve	involve	VB
cord-295807-68sukdb1	9	35	the	the	DT
cord-295807-68sukdb1	9	36	administration	administration	NN
cord-295807-68sukdb1	9	37	of	of	IN
cord-295807-68sukdb1	9	38	baking	baking	NNP
cord-295807-68sukdb1	9	39	soda	soda	NN
cord-295807-68sukdb1	9	40	(	(	-LRB-
cord-295807-68sukdb1	9	41	sodium	sodium	NN
cord-295807-68sukdb1	9	42	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	9	43	)	)	-RRB-
cord-295807-68sukdb1	9	44	.	.	.
cord-295807-68sukdb1	10	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	10	2	,	,	,
cord-295807-68sukdb1	10	3	we	-PRON-	PRP
cord-295807-68sukdb1	10	4	discuss	discuss	VBP
cord-295807-68sukdb1	10	5	the	the	DT
cord-295807-68sukdb1	10	6	side	side	JJ
cord-295807-68sukdb1	10	7	effects	effect	NNS
cord-295807-68sukdb1	10	8	of	of	IN
cord-295807-68sukdb1	10	9	pharmaceuticals	pharmaceutical	NNS
cord-295807-68sukdb1	10	10	on	on	IN
cord-295807-68sukdb1	10	11	acid	acid	NN
cord-295807-68sukdb1	10	12	-	-	HYPH
cord-295807-68sukdb1	10	13	base	base	NN
cord-295807-68sukdb1	10	14	balance	balance	NN
cord-295807-68sukdb1	10	15	as	as	RB
cord-295807-68sukdb1	10	16	well	well	RB
cord-295807-68sukdb1	10	17	as	as	IN
cord-295807-68sukdb1	10	18	the	the	DT
cord-295807-68sukdb1	10	19	influence	influence	NN
cord-295807-68sukdb1	10	20	of	of	IN
cord-295807-68sukdb1	10	21	acid	acid	NN
cord-295807-68sukdb1	10	22	-	-	HYPH
cord-295807-68sukdb1	10	23	base	base	NN
cord-295807-68sukdb1	10	24	status	status	NN
cord-295807-68sukdb1	10	25	on	on	IN
cord-295807-68sukdb1	10	26	pharmacokinetic	pharmacokinetic	JJ
cord-295807-68sukdb1	10	27	properties	property	NNS
cord-295807-68sukdb1	10	28	of	of	IN
cord-295807-68sukdb1	10	29	drugs	drug	NNS
cord-295807-68sukdb1	10	30	.	.	.
cord-295807-68sukdb1	11	1	Our	-PRON-	PRP$
cord-295807-68sukdb1	11	2	review	review	NN
cord-295807-68sukdb1	11	3	considers	consider	VBZ
cord-295807-68sukdb1	11	4	all	all	DT
cord-295807-68sukdb1	11	5	major	major	JJ
cord-295807-68sukdb1	11	6	organs	organ	NNS
cord-295807-68sukdb1	11	7	systems	system	NNS
cord-295807-68sukdb1	11	8	as	as	RB
cord-295807-68sukdb1	11	9	well	well	RB
cord-295807-68sukdb1	11	10	as	as	IN
cord-295807-68sukdb1	11	11	information	information	NN
cord-295807-68sukdb1	11	12	relevant	relevant	JJ
cord-295807-68sukdb1	11	13	to	to	IN
cord-295807-68sukdb1	11	14	several	several	JJ
cord-295807-68sukdb1	11	15	clinical	clinical	JJ
cord-295807-68sukdb1	11	16	specialties	specialty	NNS
cord-295807-68sukdb1	11	17	such	such	JJ
cord-295807-68sukdb1	11	18	as	as	IN
cord-295807-68sukdb1	11	19	anesthesiology	anesthesiology	NN
cord-295807-68sukdb1	11	20	,	,	,
cord-295807-68sukdb1	11	21	infectious	infectious	JJ
cord-295807-68sukdb1	11	22	disease	disease	NN
cord-295807-68sukdb1	11	23	,	,	,
cord-295807-68sukdb1	11	24	oncology	oncology	NN
cord-295807-68sukdb1	11	25	,	,	,
cord-295807-68sukdb1	11	26	dentistry	dentistry	NN
cord-295807-68sukdb1	11	27	,	,	,
cord-295807-68sukdb1	11	28	and	and	CC
cord-295807-68sukdb1	11	29	surgery	surgery	NN
cord-295807-68sukdb1	11	30	.	.	.
cord-295807-68sukdb1	12	1	The	the	DT
cord-295807-68sukdb1	12	2	normal	normal	JJ
cord-295807-68sukdb1	12	3	function	function	NN
cord-295807-68sukdb1	12	4	of	of	IN
cord-295807-68sukdb1	12	5	nearly	nearly	RB
cord-295807-68sukdb1	12	6	all	all	DT
cord-295807-68sukdb1	12	7	physiological	physiological	JJ
cord-295807-68sukdb1	12	8	processes	process	NNS
cord-295807-68sukdb1	12	9	in	in	IN
cord-295807-68sukdb1	12	10	the	the	DT
cord-295807-68sukdb1	12	11	body	body	NN
cord-295807-68sukdb1	12	12	depends	depend	VBZ
cord-295807-68sukdb1	12	13	on	on	IN
cord-295807-68sukdb1	12	14	maintenance	maintenance	NN
cord-295807-68sukdb1	12	15	of	of	IN
cord-295807-68sukdb1	12	16	appropriate	appropriate	JJ
cord-295807-68sukdb1	12	17	acid	acid	NN
cord-295807-68sukdb1	12	18	-	-	HYPH
cord-295807-68sukdb1	12	19	base	base	NN
cord-295807-68sukdb1	12	20	balance	balance	NN
cord-295807-68sukdb1	12	21	.	.	.
cord-295807-68sukdb1	13	1	The	the	DT
cord-295807-68sukdb1	13	2	value	value	NN
cord-295807-68sukdb1	13	3	of	of	IN
cord-295807-68sukdb1	13	4	intracellular	intracellular	JJ
cord-295807-68sukdb1	13	5	pH	ph	NN
cord-295807-68sukdb1	13	6	and	and	CC
cord-295807-68sukdb1	13	7	interstitial	interstitial	JJ
cord-295807-68sukdb1	13	8	pH	pH	NNP
cord-295807-68sukdb1	13	9	strongly	strongly	RB
cord-295807-68sukdb1	13	10	depends	depend	VBZ
cord-295807-68sukdb1	13	11	on	on	IN
cord-295807-68sukdb1	13	12	the	the	DT
cord-295807-68sukdb1	13	13	value	value	NN
cord-295807-68sukdb1	13	14	of	of	IN
cord-295807-68sukdb1	13	15	arterial	arterial	JJ
cord-295807-68sukdb1	13	16	blood	blood	NN
cord-295807-68sukdb1	13	17	pH	ph	NN
cord-295807-68sukdb1	13	18	,	,	,
cord-295807-68sukdb1	13	19	which	which	WDT
cord-295807-68sukdb1	13	20	ranges	range	VBZ
cord-295807-68sukdb1	13	21	between	between	IN
cord-295807-68sukdb1	13	22	7.35	7.35	CD
cord-295807-68sukdb1	13	23	and	and	CC
cord-295807-68sukdb1	13	24	7.45	7.45	CD
cord-295807-68sukdb1	13	25	under	under	IN
cord-295807-68sukdb1	13	26	normal	normal	JJ
cord-295807-68sukdb1	13	27	physiological	physiological	JJ
cord-295807-68sukdb1	13	28	conditions	condition	NNS
cord-295807-68sukdb1	13	29	.	.	.
cord-295807-68sukdb1	14	1	When	when	WRB
cord-295807-68sukdb1	14	2	pH	pH	NNP
cord-295807-68sukdb1	14	3	deviates	deviate	VBZ
cord-295807-68sukdb1	14	4	from	from	IN
cord-295807-68sukdb1	14	5	its	-PRON-	PRP$
cord-295807-68sukdb1	14	6	normal	normal	JJ
cord-295807-68sukdb1	14	7	range	range	NN
cord-295807-68sukdb1	14	8	,	,	,
cord-295807-68sukdb1	14	9	pH	ph	NN
cord-295807-68sukdb1	14	10	-	-	HYPH
cord-295807-68sukdb1	14	11	dependent	dependent	JJ
cord-295807-68sukdb1	14	12	enzymes	enzyme	NNS
cord-295807-68sukdb1	14	13	and	and	CC
cord-295807-68sukdb1	14	14	membrane	membrane	NN
cord-295807-68sukdb1	14	15	transport	transport	NN
cord-295807-68sukdb1	14	16	proteins	protein	NNS
cord-295807-68sukdb1	14	17	may	may	MD
cord-295807-68sukdb1	14	18	not	not	RB
cord-295807-68sukdb1	14	19	work	work	VB
cord-295807-68sukdb1	14	20	properly	properly	RB
cord-295807-68sukdb1	14	21	and	and	CC
cord-295807-68sukdb1	14	22	metabolic	metabolic	JJ
cord-295807-68sukdb1	14	23	pathways	pathway	NNS
cord-295807-68sukdb1	14	24	can	can	MD
cord-295807-68sukdb1	14	25	be	be	VB
cord-295807-68sukdb1	14	26	negatively	negatively	RB
cord-295807-68sukdb1	14	27	affected	affect	VBN
cord-295807-68sukdb1	14	28	.	.	.
cord-295807-68sukdb1	15	1	Acidemia	Acidemia	NNP
cord-295807-68sukdb1	15	2	,	,	,
cord-295807-68sukdb1	15	3	which	which	WDT
cord-295807-68sukdb1	15	4	is	be	VBZ
cord-295807-68sukdb1	15	5	defined	define	VBN
cord-295807-68sukdb1	15	6	as	as	IN
cord-295807-68sukdb1	15	7	arterial	arterial	JJ
cord-295807-68sukdb1	15	8	pH	ph	NN
cord-295807-68sukdb1	15	9	lower	low	JJR
cord-295807-68sukdb1	15	10	than	than	IN
cord-295807-68sukdb1	15	11	7.35	7.35	CD
cord-295807-68sukdb1	15	12	,	,	,
cord-295807-68sukdb1	15	13	can	can	MD
cord-295807-68sukdb1	15	14	cause	cause	VB
cord-295807-68sukdb1	15	15	a	a	DT
cord-295807-68sukdb1	15	16	variety	variety	NN
cord-295807-68sukdb1	15	17	of	of	IN
cord-295807-68sukdb1	15	18	disturbances	disturbance	NNS
cord-295807-68sukdb1	15	19	including	include	VBG
cord-295807-68sukdb1	15	20	arterial	arterial	JJ
cord-295807-68sukdb1	15	21	vasodilation	vasodilation	NN
cord-295807-68sukdb1	15	22	,	,	,
cord-295807-68sukdb1	15	23	insulin	insulin	NN
cord-295807-68sukdb1	15	24	resistance	resistance	NN
cord-295807-68sukdb1	15	25	,	,	,
cord-295807-68sukdb1	15	26	compromised	compromise	VBN
cord-295807-68sukdb1	15	27	immune	immune	JJ
cord-295807-68sukdb1	15	28	function	function	NN
cord-295807-68sukdb1	15	29	,	,	,
cord-295807-68sukdb1	15	30	and	and	CC
cord-295807-68sukdb1	15	31	reduced	reduce	VBN
cord-295807-68sukdb1	15	32	neuronal	neuronal	JJ
cord-295807-68sukdb1	15	33	excitability	excitability	NN
cord-295807-68sukdb1	15	34	.	.	.
cord-295807-68sukdb1	16	1	Alkalemia	Alkalemia	NNP
cord-295807-68sukdb1	16	2	,	,	,
cord-295807-68sukdb1	16	3	which	which	WDT
cord-295807-68sukdb1	16	4	is	be	VBZ
cord-295807-68sukdb1	16	5	defined	define	VBN
cord-295807-68sukdb1	16	6	as	as	IN
cord-295807-68sukdb1	16	7	arterial	arterial	JJ
cord-295807-68sukdb1	16	8	pH	ph	NN
cord-295807-68sukdb1	16	9	greater	great	JJR
cord-295807-68sukdb1	16	10	than	than	IN
cord-295807-68sukdb1	16	11	7.45	7.45	CD
cord-295807-68sukdb1	16	12	,	,	,
cord-295807-68sukdb1	16	13	can	can	MD
cord-295807-68sukdb1	16	14	also	also	RB
cord-295807-68sukdb1	16	15	cause	cause	VB
cord-295807-68sukdb1	16	16	many	many	JJ
cord-295807-68sukdb1	16	17	disturbances	disturbance	NNS
cord-295807-68sukdb1	16	18	including	include	VBG
cord-295807-68sukdb1	16	19	reduced	reduce	VBN
cord-295807-68sukdb1	16	20	myocardial	myocardial	JJ
cord-295807-68sukdb1	16	21	blood	blood	NN
cord-295807-68sukdb1	16	22	flow	flow	NN
cord-295807-68sukdb1	16	23	and	and	CC
cord-295807-68sukdb1	16	24	seizures	seizure	NNS
cord-295807-68sukdb1	16	25	.	.	.
cord-295807-68sukdb1	17	1	Thus	thus	RB
cord-295807-68sukdb1	17	2	,	,	,
cord-295807-68sukdb1	17	3	it	-PRON-	PRP
cord-295807-68sukdb1	17	4	is	be	VBZ
cord-295807-68sukdb1	17	5	imperative	imperative	JJ
cord-295807-68sukdb1	17	6	that	that	IN
cord-295807-68sukdb1	17	7	the	the	DT
cord-295807-68sukdb1	17	8	value	value	NN
cord-295807-68sukdb1	17	9	of	of	IN
cord-295807-68sukdb1	17	10	blood	blood	NN
cord-295807-68sukdb1	17	11	pH	ph	NN
cord-295807-68sukdb1	17	12	is	be	VBZ
cord-295807-68sukdb1	17	13	tightly	tightly	RB
cord-295807-68sukdb1	17	14	controlled	control	VBN
cord-295807-68sukdb1	17	15	.	.	.
cord-295807-68sukdb1	18	1	Therapies	therapy	NNS
cord-295807-68sukdb1	18	2	for	for	IN
cord-295807-68sukdb1	18	3	acid	acid	NN
cord-295807-68sukdb1	18	4	-	-	HYPH
cord-295807-68sukdb1	18	5	base	base	NN
cord-295807-68sukdb1	18	6	disturbances	disturbance	NNS
cord-295807-68sukdb1	18	7	are	be	VBP
cord-295807-68sukdb1	18	8	not	not	RB
cord-295807-68sukdb1	18	9	new	new	JJ
cord-295807-68sukdb1	18	10	.	.	.
cord-295807-68sukdb1	19	1	Infusion	infusion	NN
cord-295807-68sukdb1	19	2	of	of	IN
cord-295807-68sukdb1	19	3	sodium	sodium	NN
cord-295807-68sukdb1	19	4	carbonate	carbonate	NN
cord-295807-68sukdb1	19	5	(	(	-LRB-
cord-295807-68sukdb1	19	6	Na2CO3	Na2CO3	NNP
cord-295807-68sukdb1	19	7	)	)	-RRB-
cord-295807-68sukdb1	19	8	into	into	IN
cord-295807-68sukdb1	19	9	cholera	cholera	NN
cord-295807-68sukdb1	19	10	patients	patient	NNS
cord-295807-68sukdb1	19	11	to	to	TO
cord-295807-68sukdb1	19	12	compensate	compensate	VB
cord-295807-68sukdb1	19	13	for	for	IN
cord-295807-68sukdb1	19	14	loss	loss	NN
cord-295807-68sukdb1	19	15	of	of	IN
cord-295807-68sukdb1	19	16	serum	serum	NN
cord-295807-68sukdb1	19	17	alkali	alkali	NN
cord-295807-68sukdb1	19	18	in	in	IN
cord-295807-68sukdb1	19	19	diarrhea	diarrhea	NN
cord-295807-68sukdb1	19	20	was	be	VBD
cord-295807-68sukdb1	19	21	recorded	record	VBN
cord-295807-68sukdb1	19	22	in	in	IN
cord-295807-68sukdb1	19	23	the	the	DT
cord-295807-68sukdb1	19	24	1830s	1830s	CD
cord-295807-68sukdb1	19	25	[	[	-LRB-
cord-295807-68sukdb1	19	26	1	1	CD
cord-295807-68sukdb1	19	27	]	]	-RRB-
cord-295807-68sukdb1	19	28	and	and	CC
cord-295807-68sukdb1	19	29	the	the	DT
cord-295807-68sukdb1	19	30	commercial	commercial	JJ
cord-295807-68sukdb1	19	31	production	production	NN
cord-295807-68sukdb1	19	32	of	of	IN
cord-295807-68sukdb1	19	33	sodium	sodium	NN
cord-295807-68sukdb1	19	34	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	19	35	(	(	-LRB-
cord-295807-68sukdb1	19	36	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	19	37	)	)	-RRB-
cord-295807-68sukdb1	19	38	for	for	IN
cord-295807-68sukdb1	19	39	use	use	NN
cord-295807-68sukdb1	19	40	as	as	IN
cord-295807-68sukdb1	19	41	an	an	DT
cord-295807-68sukdb1	19	42	antacid	antacid	NN
cord-295807-68sukdb1	19	43	(	(	-LRB-
cord-295807-68sukdb1	19	44	Brioschi	Brioschi	NNP
cord-295807-68sukdb1	19	45	®	®	NNP
cord-295807-68sukdb1	19	46	)	)	-RRB-
cord-295807-68sukdb1	19	47	apparently	apparently	RB
cord-295807-68sukdb1	19	48	dates	date	VBZ
cord-295807-68sukdb1	19	49	back	back	RB
cord-295807-68sukdb1	19	50	to	to	IN
cord-295807-68sukdb1	19	51	the	the	DT
cord-295807-68sukdb1	19	52	1880s	1880s	CD
cord-295807-68sukdb1	19	53	.	.	.
cord-295807-68sukdb1	20	1	Since	since	IN
cord-295807-68sukdb1	20	2	then	then	RB
cord-295807-68sukdb1	20	3	,	,	,
cord-295807-68sukdb1	20	4	decades	decade	NNS
cord-295807-68sukdb1	20	5	of	of	IN
cord-295807-68sukdb1	20	6	research	research	NN
cord-295807-68sukdb1	20	7	advances	advance	NNS
cord-295807-68sukdb1	20	8	have	have	VBP
cord-295807-68sukdb1	20	9	led	lead	VBN
cord-295807-68sukdb1	20	10	to	to	IN
cord-295807-68sukdb1	20	11	a	a	DT
cord-295807-68sukdb1	20	12	broad	broad	JJ
cord-295807-68sukdb1	20	13	appreciation	appreciation	NN
cord-295807-68sukdb1	20	14	of	of	IN
cord-295807-68sukdb1	20	15	the	the	DT
cord-295807-68sukdb1	20	16	importance	importance	NN
cord-295807-68sukdb1	20	17	of	of	IN
cord-295807-68sukdb1	20	18	acid	acid	NN
cord-295807-68sukdb1	20	19	-	-	HYPH
cord-295807-68sukdb1	20	20	base	base	NN
cord-295807-68sukdb1	20	21	balance	balance	NN
cord-295807-68sukdb1	20	22	in	in	IN
cord-295807-68sukdb1	20	23	health	health	NN
cord-295807-68sukdb1	20	24	and	and	CC
cord-295807-68sukdb1	20	25	disease	disease	NN
cord-295807-68sukdb1	20	26	.	.	.
cord-295807-68sukdb1	21	1	This	this	DT
cord-295807-68sukdb1	21	2	research	research	NN
cord-295807-68sukdb1	21	3	is	be	VBZ
cord-295807-68sukdb1	21	4	now	now	RB
cord-295807-68sukdb1	21	5	coming	come	VBG
cord-295807-68sukdb1	21	6	to	to	IN
cord-295807-68sukdb1	21	7	fruition	fruition	NN
cord-295807-68sukdb1	21	8	in	in	IN
cord-295807-68sukdb1	21	9	the	the	DT
cord-295807-68sukdb1	21	10	form	form	NN
cord-295807-68sukdb1	21	11	of	of	IN
cord-295807-68sukdb1	21	12	inspired	inspire	VBN
cord-295807-68sukdb1	21	13	and	and	CC
cord-295807-68sukdb1	21	14	effective	effective	JJ
cord-295807-68sukdb1	21	15	medical	medical	JJ
cord-295807-68sukdb1	21	16	advances	advance	NNS
cord-295807-68sukdb1	21	17	.	.	.
cord-295807-68sukdb1	22	1	At	at	IN
cord-295807-68sukdb1	22	2	the	the	DT
cord-295807-68sukdb1	22	3	same	same	JJ
cord-295807-68sukdb1	22	4	time	time	NN
cord-295807-68sukdb1	22	5	,	,	,
cord-295807-68sukdb1	22	6	some	some	DT
cord-295807-68sukdb1	22	7	in	in	IN
cord-295807-68sukdb1	22	8	the	the	DT
cord-295807-68sukdb1	22	9	alternative	alternative	JJ
cord-295807-68sukdb1	22	10	medical	medical	JJ
cord-295807-68sukdb1	22	11	community	community	NN
cord-295807-68sukdb1	22	12	have	have	VBP
cord-295807-68sukdb1	22	13	seized	seize	VBN
cord-295807-68sukdb1	22	14	on	on	IN
cord-295807-68sukdb1	22	15	anecdotes	anecdote	NNS
cord-295807-68sukdb1	22	16	and	and	CC
cord-295807-68sukdb1	22	17	the	the	DT
cord-295807-68sukdb1	22	18	results	result	NNS
cord-295807-68sukdb1	22	19	of	of	IN
cord-295807-68sukdb1	22	20	limited	limited	JJ
cord-295807-68sukdb1	22	21	trials	trial	NNS
cord-295807-68sukdb1	22	22	to	to	TO
cord-295807-68sukdb1	22	23	generate	generate	VB
cord-295807-68sukdb1	22	24	ubiquitous	ubiquitous	JJ
cord-295807-68sukdb1	22	25	clickbait	clickbait	JJ
cord-295807-68sukdb1	22	26	headlines	headline	NNS
cord-295807-68sukdb1	22	27	about	about	IN
cord-295807-68sukdb1	22	28	the	the	DT
cord-295807-68sukdb1	22	29	miraculous	miraculous	JJ
cord-295807-68sukdb1	22	30	properties	property	NNS
cord-295807-68sukdb1	22	31	of	of	IN
cord-295807-68sukdb1	22	32	household	household	NN
cord-295807-68sukdb1	22	33	acids	acid	NNS
cord-295807-68sukdb1	22	34	and	and	CC
cord-295807-68sukdb1	22	35	bases	basis	NNS
cord-295807-68sukdb1	22	36	such	such	JJ
cord-295807-68sukdb1	22	37	as	as	IN
cord-295807-68sukdb1	22	38	baking	baking	NN
cord-295807-68sukdb1	22	39	soda	soda	NN
cord-295807-68sukdb1	22	40	and	and	CC
cord-295807-68sukdb1	22	41	,	,	,
cord-295807-68sukdb1	22	42	in	in	IN
cord-295807-68sukdb1	22	43	some	some	DT
cord-295807-68sukdb1	22	44	cases	case	NNS
cord-295807-68sukdb1	22	45	,	,	,
cord-295807-68sukdb1	22	46	propagate	propagate	VBP
cord-295807-68sukdb1	22	47	conspiracy	conspiracy	NN
cord-295807-68sukdb1	22	48	theories	theory	NNS
cord-295807-68sukdb1	22	49	about	about	IN
cord-295807-68sukdb1	22	50	suppression	suppression	NN
cord-295807-68sukdb1	22	51	of	of	IN
cord-295807-68sukdb1	22	52	this	this	DT
cord-295807-68sukdb1	22	53	information	information	NN
cord-295807-68sukdb1	22	54	.	.	.
cord-295807-68sukdb1	23	1	In	in	IN
cord-295807-68sukdb1	23	2	the	the	DT
cord-295807-68sukdb1	23	3	first	first	JJ
cord-295807-68sukdb1	23	4	major	major	JJ
cord-295807-68sukdb1	23	5	section	section	NN
cord-295807-68sukdb1	23	6	of	of	IN
cord-295807-68sukdb1	23	7	our	-PRON-	PRP$
cord-295807-68sukdb1	23	8	review	review	NN
cord-295807-68sukdb1	23	9	(	(	-LRB-
cord-295807-68sukdb1	23	10	2	2	CD
cord-295807-68sukdb1	23	11	Acid	Acid	NNP
cord-295807-68sukdb1	23	12	-	-	HYPH
cord-295807-68sukdb1	23	13	Base	Base	NNP
cord-295807-68sukdb1	23	14	Homeostasis	Homeostasis	NNP
cord-295807-68sukdb1	23	15	)	)	-RRB-
cord-295807-68sukdb1	23	16	we	-PRON-	PRP
cord-295807-68sukdb1	23	17	discuss	discuss	VBP
cord-295807-68sukdb1	23	18	how	how	WRB
cord-295807-68sukdb1	23	19	the	the	DT
cord-295807-68sukdb1	23	20	body	body	NN
cord-295807-68sukdb1	23	21	controls	control	VBZ
cord-295807-68sukdb1	23	22	the	the	DT
cord-295807-68sukdb1	23	23	abundance	abundance	NN
cord-295807-68sukdb1	23	24	and	and	CC
cord-295807-68sukdb1	23	25	distribution	distribution	NN
cord-295807-68sukdb1	23	26	of	of	IN
cord-295807-68sukdb1	23	27	acids	acid	NNS
cord-295807-68sukdb1	23	28	and	and	CC
cord-295807-68sukdb1	23	29	bases	basis	NNS
cord-295807-68sukdb1	23	30	in	in	IN
cord-295807-68sukdb1	23	31	order	order	NN
cord-295807-68sukdb1	23	32	to	to	TO
cord-295807-68sukdb1	23	33	achieve	achieve	VB
cord-295807-68sukdb1	23	34	acid	acid	NN
cord-295807-68sukdb1	23	35	base	base	NN
cord-295807-68sukdb1	23	36	homeostasis	homeostasis	NN
cord-295807-68sukdb1	23	37	.	.	.
cord-295807-68sukdb1	24	1	We	-PRON-	PRP
cord-295807-68sukdb1	24	2	describe	describe	VBP
cord-295807-68sukdb1	24	3	the	the	DT
cord-295807-68sukdb1	24	4	importance	importance	NN
cord-295807-68sukdb1	24	5	of	of	IN
cord-295807-68sukdb1	24	6	the	the	DT
cord-295807-68sukdb1	24	7	powerful	powerful	JJ
cord-295807-68sukdb1	24	8	CO2	CO2	NNP
cord-295807-68sukdb1	24	9	/	/	SYM
cord-295807-68sukdb1	24	10	HCO3buffer	HCO3buffer	NNP
cord-295807-68sukdb1	24	11	system	system	NN
cord-295807-68sukdb1	24	12	,	,	,
cord-295807-68sukdb1	24	13	the	the	DT
cord-295807-68sukdb1	24	14	vital	vital	JJ
cord-295807-68sukdb1	24	15	functions	function	NNS
cord-295807-68sukdb1	24	16	of	of	IN
cord-295807-68sukdb1	24	17	the	the	DT
cord-295807-68sukdb1	24	18	lungs	lung	NNS
cord-295807-68sukdb1	24	19	and	and	CC
cord-295807-68sukdb1	24	20	kidneys	kidney	NNS
cord-295807-68sukdb1	24	21	in	in	IN
cord-295807-68sukdb1	24	22	excreting	excrete	VBG
cord-295807-68sukdb1	24	23	excess	excess	JJ
cord-295807-68sukdb1	24	24	acids	acid	NNS
cord-295807-68sukdb1	24	25	and	and	CC
cord-295807-68sukdb1	24	26	bases	basis	NNS
cord-295807-68sukdb1	24	27	,	,	,
cord-295807-68sukdb1	24	28	the	the	DT
cord-295807-68sukdb1	24	29	role	role	NN
cord-295807-68sukdb1	24	30	of	of	IN
cord-295807-68sukdb1	24	31	membrane	membrane	NN
cord-295807-68sukdb1	24	32	transport	transport	NN
cord-295807-68sukdb1	24	33	proteins	protein	NNS
cord-295807-68sukdb1	24	34	and	and	CC
cord-295807-68sukdb1	24	35	carbonic	carbonic	JJ
cord-295807-68sukdb1	24	36	anhydrases	anhydrase	NNS
cord-295807-68sukdb1	24	37	in	in	IN
cord-295807-68sukdb1	24	38	the	the	DT
cord-295807-68sukdb1	24	39	local	local	JJ
cord-295807-68sukdb1	24	40	redistribution	redistribution	NN
cord-295807-68sukdb1	24	41	of	of	IN
cord-295807-68sukdb1	24	42	acids	acid	NNS
cord-295807-68sukdb1	24	43	and	and	CC
cord-295807-68sukdb1	24	44	bases	basis	NNS
cord-295807-68sukdb1	24	45	,	,	,
cord-295807-68sukdb1	24	46	and	and	CC
cord-295807-68sukdb1	24	47	the	the	DT
cord-295807-68sukdb1	24	48	drugs	drug	NNS
cord-295807-68sukdb1	24	49	that	that	WDT
cord-295807-68sukdb1	24	50	can	can	MD
cord-295807-68sukdb1	24	51	be	be	VB
cord-295807-68sukdb1	24	52	harnessed	harness	VBN
cord-295807-68sukdb1	24	53	to	to	TO
cord-295807-68sukdb1	24	54	control	control	VB
cord-295807-68sukdb1	24	55	these	these	DT
cord-295807-68sukdb1	24	56	processes	process	NNS
cord-295807-68sukdb1	24	57	.	.	.
cord-295807-68sukdb1	25	1	In	in	IN
cord-295807-68sukdb1	25	2	the	the	DT
cord-295807-68sukdb1	25	3	second	second	JJ
cord-295807-68sukdb1	25	4	major	major	JJ
cord-295807-68sukdb1	25	5	section	section	NN
cord-295807-68sukdb1	25	6	of	of	IN
cord-295807-68sukdb1	25	7	our	-PRON-	PRP$
cord-295807-68sukdb1	25	8	review	review	NN
cord-295807-68sukdb1	25	9	(	(	-LRB-
cord-295807-68sukdb1	25	10	3	3	CD
cord-295807-68sukdb1	25	11	Systemic	systemic	JJ
cord-295807-68sukdb1	25	12	Acid	acid	NN
cord-295807-68sukdb1	25	13	-	-	HYPH
cord-295807-68sukdb1	25	14	base	base	NN
cord-295807-68sukdb1	25	15	Disturbances	disturbance	NNS
cord-295807-68sukdb1	25	16	)	)	-RRB-
cord-295807-68sukdb1	25	17	we	-PRON-	PRP
cord-295807-68sukdb1	25	18	discuss	discuss	VBP
cord-295807-68sukdb1	25	19	the	the	DT
cord-295807-68sukdb1	25	20	causes	cause	NNS
cord-295807-68sukdb1	25	21	and	and	CC
cord-295807-68sukdb1	25	22	consequences	consequence	NNS
cord-295807-68sukdb1	25	23	of	of	IN
cord-295807-68sukdb1	25	24	generic	generic	JJ
cord-295807-68sukdb1	25	25	acidbase	acidbase	NN
cord-295807-68sukdb1	25	26	imbalance	imbalance	NN
cord-295807-68sukdb1	25	27	caused	cause	VBN
cord-295807-68sukdb1	25	28	by	by	IN
cord-295807-68sukdb1	25	29	disturbances	disturbance	NNS
cord-295807-68sukdb1	25	30	in	in	IN
cord-295807-68sukdb1	25	31	CO2	CO2	NNP
cord-295807-68sukdb1	25	32	and	and	CC
cord-295807-68sukdb1	25	33	HCO3levels	HCO3levels	NNP
cord-295807-68sukdb1	25	34	and	and	CC
cord-295807-68sukdb1	25	35	how	how	WRB
cord-295807-68sukdb1	25	36	our	-PRON-	PRP$
cord-295807-68sukdb1	25	37	knowledge	knowledge	NN
cord-295807-68sukdb1	25	38	of	of	IN
cord-295807-68sukdb1	25	39	their	-PRON-	PRP$
cord-295807-68sukdb1	25	40	etiology	etiology	NN
cord-295807-68sukdb1	25	41	has	have	VBZ
cord-295807-68sukdb1	25	42	informed	inform	VBN
cord-295807-68sukdb1	25	43	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	25	44	strategies	strategy	NNS
cord-295807-68sukdb1	25	45	.	.	.
cord-295807-68sukdb1	26	1	Our	-PRON-	PRP$
cord-295807-68sukdb1	26	2	third	third	JJ
cord-295807-68sukdb1	26	3	and	and	CC
cord-295807-68sukdb1	26	4	fourth	fourth	JJ
cord-295807-68sukdb1	26	5	major	major	JJ
cord-295807-68sukdb1	26	6	sections	section	NNS
cord-295807-68sukdb1	26	7	(	(	-LRB-
cord-295807-68sukdb1	26	8	4	4	CD
cord-295807-68sukdb1	26	9	Applications	application	NNS
cord-295807-68sukdb1	26	10	by	by	IN
cord-295807-68sukdb1	26	11	Organ	Organ	NNP
cord-295807-68sukdb1	26	12	System	System	NNP
cord-295807-68sukdb1	26	13	and	and	CC
cord-295807-68sukdb1	26	14	5	5	CD
cord-295807-68sukdb1	26	15	Other	other	JJ
cord-295807-68sukdb1	26	16	Applications	Applications	NNPS
cord-295807-68sukdb1	26	17	by	by	IN
cord-295807-68sukdb1	26	18	Clinical	Clinical	NNP
cord-295807-68sukdb1	26	19	Specialty	Specialty	NNP
cord-295807-68sukdb1	26	20	)	)	-RRB-
cord-295807-68sukdb1	26	21	bring	bring	VB
cord-295807-68sukdb1	26	22	together	together	RB
cord-295807-68sukdb1	26	23	a	a	DT
cord-295807-68sukdb1	26	24	wealth	wealth	NN
cord-295807-68sukdb1	26	25	of	of	IN
cord-295807-68sukdb1	26	26	information	information	NN
cord-295807-68sukdb1	26	27	from	from	IN
cord-295807-68sukdb1	26	28	in	in	IN
cord-295807-68sukdb1	26	29	vitro	vitro	FW
cord-295807-68sukdb1	26	30	,	,	,
cord-295807-68sukdb1	26	31	in	in	IN
cord-295807-68sukdb1	26	32	vivo	vivo	NN
cord-295807-68sukdb1	26	33	,	,	,
cord-295807-68sukdb1	26	34	and	and	CC
cord-295807-68sukdb1	26	35	clinical	clinical	JJ
cord-295807-68sukdb1	26	36	studies	study	NNS
cord-295807-68sukdb1	26	37	that	that	WDT
cord-295807-68sukdb1	26	38	demonstrate	demonstrate	VBP
cord-295807-68sukdb1	26	39	the	the	DT
cord-295807-68sukdb1	26	40	current	current	JJ
cord-295807-68sukdb1	26	41	and	and	CC
cord-295807-68sukdb1	26	42	potential	potential	JJ
cord-295807-68sukdb1	26	43	utility	utility	NN
cord-295807-68sukdb1	26	44	of	of	IN
cord-295807-68sukdb1	26	45	acid	acid	NN
cord-295807-68sukdb1	26	46	-	-	HYPH
cord-295807-68sukdb1	26	47	base	base	NN
cord-295807-68sukdb1	26	48	-	-	HYPH
cord-295807-68sukdb1	26	49	balance	balance	NN
cord-295807-68sukdb1	26	50	correcting	correct	VBG
cord-295807-68sukdb1	26	51	therapies	therapy	NNS
cord-295807-68sukdb1	26	52	.	.	.
cord-295807-68sukdb1	27	1	For	for	IN
cord-295807-68sukdb1	27	2	each	each	DT
cord-295807-68sukdb1	27	3	organ	organ	NN
cord-295807-68sukdb1	27	4	system	system	NN
cord-295807-68sukdb1	27	5	or	or	CC
cord-295807-68sukdb1	27	6	clinical	clinical	JJ
cord-295807-68sukdb1	27	7	specialization	specialization	NN
cord-295807-68sukdb1	27	8	,	,	,
cord-295807-68sukdb1	27	9	as	as	IN
cord-295807-68sukdb1	27	10	appropriate	appropriate	JJ
cord-295807-68sukdb1	27	11	,	,	,
cord-295807-68sukdb1	27	12	we	-PRON-	PRP
cord-295807-68sukdb1	27	13	provide	provide	VBP
cord-295807-68sukdb1	27	14	the	the	DT
cord-295807-68sukdb1	27	15	fundamental	fundamental	JJ
cord-295807-68sukdb1	27	16	physiological	physiological	JJ
cord-295807-68sukdb1	27	17	aspects	aspect	NNS
cord-295807-68sukdb1	27	18	of	of	IN
cord-295807-68sukdb1	27	19	normal	normal	JJ
cord-295807-68sukdb1	27	20	acid	acid	NN
cord-295807-68sukdb1	27	21	-	-	HYPH
cord-295807-68sukdb1	27	22	base	base	NN
cord-295807-68sukdb1	27	23	balance	balance	NN
cord-295807-68sukdb1	27	24	,	,	,
cord-295807-68sukdb1	27	25	the	the	DT
cord-295807-68sukdb1	27	26	pathological	pathological	JJ
cord-295807-68sukdb1	27	27	consequences	consequence	NNS
cord-295807-68sukdb1	27	28	of	of	IN
cord-295807-68sukdb1	27	29	systemic	systemic	JJ
cord-295807-68sukdb1	27	30	and	and	CC
cord-295807-68sukdb1	27	31	local	local	JJ
cord-295807-68sukdb1	27	32	acid	acid	NN
cord-295807-68sukdb1	27	33	-	-	HYPH
cord-295807-68sukdb1	27	34	base	base	NN
cord-295807-68sukdb1	27	35	disturbances	disturbance	NNS
cord-295807-68sukdb1	27	36	,	,	,
cord-295807-68sukdb1	27	37	as	as	RB
cord-295807-68sukdb1	27	38	well	well	RB
cord-295807-68sukdb1	27	39	as	as	IN
cord-295807-68sukdb1	27	40	considerations	consideration	NNS
cord-295807-68sukdb1	27	41	of	of	IN
cord-295807-68sukdb1	27	42	corrective	corrective	JJ
cord-295807-68sukdb1	27	43	therapies	therapy	NNS
cord-295807-68sukdb1	27	44	based	base	VBN
cord-295807-68sukdb1	27	45	on	on	IN
cord-295807-68sukdb1	27	46	restoring	restore	VBG
cord-295807-68sukdb1	27	47	(	(	-LRB-
cord-295807-68sukdb1	27	48	or	or	CC
cord-295807-68sukdb1	27	49	harnessing	harness	VBG
cord-295807-68sukdb1	27	50	the	the	DT
cord-295807-68sukdb1	27	51	agents	agent	NNS
cord-295807-68sukdb1	27	52	of	of	IN
cord-295807-68sukdb1	27	53	)	)	-RRB-
cord-295807-68sukdb1	27	54	acid	acid	NN
cord-295807-68sukdb1	27	55	-	-	HYPH
cord-295807-68sukdb1	27	56	base	base	NN
cord-295807-68sukdb1	27	57	balance	balance	NN
cord-295807-68sukdb1	27	58	.	.	.
cord-295807-68sukdb1	28	1	In	in	IN
cord-295807-68sukdb1	28	2	our	-PRON-	PRP$
cord-295807-68sukdb1	28	3	fifth	fifth	JJ
cord-295807-68sukdb1	28	4	and	and	CC
cord-295807-68sukdb1	28	5	final	final	JJ
cord-295807-68sukdb1	28	6	major	major	JJ
cord-295807-68sukdb1	28	7	section	section	NN
cord-295807-68sukdb1	28	8	(	(	-LRB-
cord-295807-68sukdb1	28	9	6	6	CD
cord-295807-68sukdb1	28	10	pH	ph	JJ
cord-295807-68sukdb1	28	11	-	-	HYPH
cord-295807-68sukdb1	28	12	dependent	dependent	JJ
cord-295807-68sukdb1	28	13	aspects	aspect	NNS
cord-295807-68sukdb1	28	14	of	of	IN
cord-295807-68sukdb1	28	15	pharmaceutical	pharmaceutical	NN
cord-295807-68sukdb1	28	16	therapy	therapy	NN
cord-295807-68sukdb1	28	17	)	)	-RRB-
cord-295807-68sukdb1	28	18	we	-PRON-	PRP
cord-295807-68sukdb1	28	19	discuss	discuss	VBP
cord-295807-68sukdb1	28	20	how	how	WRB
cord-295807-68sukdb1	28	21	acid	acid	NN
cord-295807-68sukdb1	28	22	-	-	HYPH
cord-295807-68sukdb1	28	23	base	base	NN
cord-295807-68sukdb1	28	24	chemistry	chemistry	NN
cord-295807-68sukdb1	28	25	can	can	MD
cord-295807-68sukdb1	28	26	influence	influence	VB
cord-295807-68sukdb1	28	27	drug	drug	NN
cord-295807-68sukdb1	28	28	pharmacokinetic	pharmacokinetic	JJ
cord-295807-68sukdb1	28	29	properties	property	NNS
cord-295807-68sukdb1	28	30	and	and	CC
cord-295807-68sukdb1	28	31	how	how	WRB
cord-295807-68sukdb1	28	32	this	this	DT
cord-295807-68sukdb1	28	33	phenomenon	phenomenon	NN
cord-295807-68sukdb1	28	34	can	can	MD
cord-295807-68sukdb1	28	35	be	be	VB
cord-295807-68sukdb1	28	36	advantageous	advantageous	JJ
cord-295807-68sukdb1	28	37	for	for	IN
cord-295807-68sukdb1	28	38	optimizing	optimize	VBG
cord-295807-68sukdb1	28	39	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	28	40	interventions	intervention	NNS
cord-295807-68sukdb1	28	41	.	.	.
cord-295807-68sukdb1	29	1	Our	-PRON-	PRP$
cord-295807-68sukdb1	29	2	review	review	NN
cord-295807-68sukdb1	29	3	highlights	highlight	VBZ
cord-295807-68sukdb1	29	4	an	an	DT
cord-295807-68sukdb1	29	5	emerging	emerge	VBG
cord-295807-68sukdb1	29	6	and	and	CC
cord-295807-68sukdb1	29	7	dynamic	dynamic	JJ
cord-295807-68sukdb1	29	8	field	field	NN
cord-295807-68sukdb1	29	9	of	of	IN
cord-295807-68sukdb1	29	10	research	research	NN
cord-295807-68sukdb1	29	11	that	that	WDT
cord-295807-68sukdb1	29	12	is	be	VBZ
cord-295807-68sukdb1	29	13	in	in	IN
cord-295807-68sukdb1	29	14	the	the	DT
cord-295807-68sukdb1	29	15	process	process	NN
cord-295807-68sukdb1	29	16	of	of	IN
cord-295807-68sukdb1	29	17	translating	translate	VBG
cord-295807-68sukdb1	29	18	numerous	numerous	JJ
cord-295807-68sukdb1	29	19	basic	basic	JJ
cord-295807-68sukdb1	29	20	scientific	scientific	JJ
cord-295807-68sukdb1	29	21	findings	finding	NNS
cord-295807-68sukdb1	29	22	into	into	IN
cord-295807-68sukdb1	29	23	clinical	clinical	JJ
cord-295807-68sukdb1	29	24	therapies	therapy	NNS
cord-295807-68sukdb1	29	25	.	.	.
cord-295807-68sukdb1	30	1	These	these	DT
cord-295807-68sukdb1	30	2	findings	finding	NNS
cord-295807-68sukdb1	30	3	appear	appear	VBP
cord-295807-68sukdb1	30	4	to	to	TO
cord-295807-68sukdb1	30	5	touch	touch	VB
cord-295807-68sukdb1	30	6	on	on	IN
cord-295807-68sukdb1	30	7	nearly	nearly	RB
cord-295807-68sukdb1	30	8	all	all	DT
cord-295807-68sukdb1	30	9	aspects	aspect	NNS
cord-295807-68sukdb1	30	10	of	of	IN
cord-295807-68sukdb1	30	11	health	health	NN
cord-295807-68sukdb1	30	12	.	.	.
cord-295807-68sukdb1	31	1	We	-PRON-	PRP
cord-295807-68sukdb1	31	2	note	note	VBP
cord-295807-68sukdb1	31	3	a	a	DT
cord-295807-68sukdb1	31	4	wide	wide	JJ
cord-295807-68sukdb1	31	5	array	array	NN
cord-295807-68sukdb1	31	6	of	of	IN
cord-295807-68sukdb1	31	7	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	31	8	paradigms	paradigm	NNS
cord-295807-68sukdb1	31	9	developed	develop	VBN
cord-295807-68sukdb1	31	10	around	around	IN
cord-295807-68sukdb1	31	11	the	the	DT
cord-295807-68sukdb1	31	12	control	control	NN
cord-295807-68sukdb1	31	13	of	of	IN
cord-295807-68sukdb1	31	14	acid	acid	NN
cord-295807-68sukdb1	31	15	-	-	HYPH
cord-295807-68sukdb1	31	16	base	base	NN
cord-295807-68sukdb1	31	17	balance	balance	NN
cord-295807-68sukdb1	31	18	including	include	VBG
cord-295807-68sukdb1	31	19	numerous	numerous	JJ
cord-295807-68sukdb1	31	20	reports	report	NNS
cord-295807-68sukdb1	31	21	of	of	IN
cord-295807-68sukdb1	31	22	the	the	DT
cord-295807-68sukdb1	31	23	successful	successful	JJ
cord-295807-68sukdb1	31	24	application	application	NN
cord-295807-68sukdb1	31	25	of	of	IN
cord-295807-68sukdb1	31	26	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	31	27	,	,	,
cord-295807-68sukdb1	31	28	the	the	DT
cord-295807-68sukdb1	31	29	so	so	RB
cord-295807-68sukdb1	31	30	-	-	HYPH
cord-295807-68sukdb1	31	31	called	call	VBN
cord-295807-68sukdb1	31	32	'	'	''
cord-295807-68sukdb1	31	33	enemy	enemy	NN
cord-295807-68sukdb1	31	34	of	of	IN
cord-295807-68sukdb1	31	35	the	the	DT
cord-295807-68sukdb1	31	36	pharmaceutical	pharmaceutical	NN
cord-295807-68sukdb1	31	37	industry	industry	NN
cord-295807-68sukdb1	31	38	,	,	,
cord-295807-68sukdb1	31	39	'	'	''
cord-295807-68sukdb1	31	40	to	to	IN
cord-295807-68sukdb1	31	41	the	the	DT
cord-295807-68sukdb1	31	42	amelioration	amelioration	NN
cord-295807-68sukdb1	31	43	of	of	IN
cord-295807-68sukdb1	31	44	disease	disease	NN
cord-295807-68sukdb1	31	45	signs	sign	NNS
cord-295807-68sukdb1	31	46	in	in	IN
cord-295807-68sukdb1	31	47	animal	animal	NN
cord-295807-68sukdb1	31	48	models	model	NNS
cord-295807-68sukdb1	31	49	and	and	CC
cord-295807-68sukdb1	31	50	in	in	IN
cord-295807-68sukdb1	31	51	limited	limited	JJ
cord-295807-68sukdb1	31	52	clinical	clinical	JJ
cord-295807-68sukdb1	31	53	trials	trial	NNS
cord-295807-68sukdb1	31	54	.	.	.
cord-295807-68sukdb1	32	1	Although	although	IN
cord-295807-68sukdb1	32	2	studies	study	NNS
cord-295807-68sukdb1	32	3	of	of	IN
cord-295807-68sukdb1	32	4	the	the	DT
cord-295807-68sukdb1	32	5	role	role	NN
cord-295807-68sukdb1	32	6	of	of	IN
cord-295807-68sukdb1	32	7	acid	acid	NN
cord-295807-68sukdb1	32	8	-	-	HYPH
cord-295807-68sukdb1	32	9	base	base	NN
cord-295807-68sukdb1	32	10	balance	balance	NN
cord-295807-68sukdb1	32	11	in	in	IN
cord-295807-68sukdb1	32	12	health	health	NN
cord-295807-68sukdb1	32	13	and	and	CC
cord-295807-68sukdb1	32	14	disease	disease	NN
cord-295807-68sukdb1	32	15	have	have	VBP
cord-295807-68sukdb1	32	16	resulted	result	VBN
cord-295807-68sukdb1	32	17	in	in	IN
cord-295807-68sukdb1	32	18	the	the	DT
cord-295807-68sukdb1	32	19	generation	generation	NN
cord-295807-68sukdb1	32	20	of	of	IN
cord-295807-68sukdb1	32	21	several	several	JJ
cord-295807-68sukdb1	32	22	FDA	FDA	NNP
cord-295807-68sukdb1	32	23	-	-	HYPH
cord-295807-68sukdb1	32	24	approved	approve	VBN
cord-295807-68sukdb1	32	25	pharmaceuticals	pharmaceutical	NNS
cord-295807-68sukdb1	32	26	such	such	JJ
cord-295807-68sukdb1	32	27	as	as	IN
cord-295807-68sukdb1	32	28	contraceptive	contraceptive	JJ
cord-295807-68sukdb1	32	29	gels	gel	NNS
cord-295807-68sukdb1	32	30	and	and	CC
cord-295807-68sukdb1	32	31	gastric	gastric	JJ
cord-295807-68sukdb1	32	32	-	-	HYPH
cord-295807-68sukdb1	32	33	acid	acid	NN
cord-295807-68sukdb1	32	34	suppressors	suppressor	NNS
cord-295807-68sukdb1	32	35	,	,	,
cord-295807-68sukdb1	32	36	systematic	systematic	JJ
cord-295807-68sukdb1	32	37	reviews	review	NNS
cord-295807-68sukdb1	32	38	of	of	IN
cord-295807-68sukdb1	32	39	random	random	JJ
cord-295807-68sukdb1	32	40	trials	trial	NNS
cord-295807-68sukdb1	32	41	of	of	IN
cord-295807-68sukdb1	32	42	the	the	DT
cord-295807-68sukdb1	32	43	clinical	clinical	JJ
cord-295807-68sukdb1	32	44	effectiveness	effectiveness	NN
cord-295807-68sukdb1	32	45	of	of	IN
cord-295807-68sukdb1	32	46	NaHCO3	nahco3	NN
cord-295807-68sukdb1	32	47	itself	-PRON-	PRP
cord-295807-68sukdb1	32	48	tend	tend	VBP
cord-295807-68sukdb1	32	49	to	to	TO
cord-295807-68sukdb1	32	50	be	be	VB
cord-295807-68sukdb1	32	51	circumspect	circumspect	JJ
cord-295807-68sukdb1	32	52	in	in	IN
cord-295807-68sukdb1	32	53	their	-PRON-	PRP$
cord-295807-68sukdb1	32	54	conclusions	conclusion	NNS
cord-295807-68sukdb1	32	55	.	.	.
cord-295807-68sukdb1	33	1	A	a	DT
cord-295807-68sukdb1	33	2	note	note	NN
cord-295807-68sukdb1	33	3	to	to	IN
cord-295807-68sukdb1	33	4	the	the	DT
cord-295807-68sukdb1	33	5	reader	reader	NN
cord-295807-68sukdb1	33	6	:	:	:
cord-295807-68sukdb1	34	1	We	-PRON-	PRP
cord-295807-68sukdb1	34	2	,	,	,
cord-295807-68sukdb1	34	3	the	the	DT
cord-295807-68sukdb1	34	4	authors	author	NNS
cord-295807-68sukdb1	34	5	,	,	,
cord-295807-68sukdb1	34	6	are	be	VBP
cord-295807-68sukdb1	34	7	basic	basic	JJ
cord-295807-68sukdb1	34	8	scientists	scientist	NNS
cord-295807-68sukdb1	34	9	and	and	CC
cord-295807-68sukdb1	34	10	do	do	VBP
cord-295807-68sukdb1	34	11	not	not	RB
cord-295807-68sukdb1	34	12	intend	intend	VB
cord-295807-68sukdb1	34	13	this	this	DT
cord-295807-68sukdb1	34	14	review	review	NN
cord-295807-68sukdb1	34	15	to	to	TO
cord-295807-68sukdb1	34	16	serve	serve	VB
cord-295807-68sukdb1	34	17	as	as	IN
cord-295807-68sukdb1	34	18	a	a	DT
cord-295807-68sukdb1	34	19	diagnostic	diagnostic	JJ
cord-295807-68sukdb1	34	20	or	or	CC
cord-295807-68sukdb1	34	21	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	34	22	guide	guide	NN
cord-295807-68sukdb1	34	23	.	.	.
cord-295807-68sukdb1	35	1	In	in	IN
cord-295807-68sukdb1	35	2	many	many	JJ
cord-295807-68sukdb1	35	3	cases	case	NNS
cord-295807-68sukdb1	35	4	,	,	,
cord-295807-68sukdb1	35	5	a	a	DT
cord-295807-68sukdb1	35	6	lack	lack	NN
cord-295807-68sukdb1	35	7	of	of	IN
cord-295807-68sukdb1	35	8	consistency	consistency	NN
cord-295807-68sukdb1	35	9	among	among	IN
cord-295807-68sukdb1	35	10	study	study	NN
cord-295807-68sukdb1	35	11	methods	method	NNS
cord-295807-68sukdb1	35	12	and	and	CC
cord-295807-68sukdb1	35	13	subject	subject	JJ
cord-295807-68sukdb1	35	14	demographics	demographic	NNS
cord-295807-68sukdb1	35	15	makes	make	VBZ
cord-295807-68sukdb1	35	16	it	-PRON-	PRP
cord-295807-68sukdb1	35	17	difficult	difficult	JJ
cord-295807-68sukdb1	35	18	to	to	TO
cord-295807-68sukdb1	35	19	draw	draw	VB
cord-295807-68sukdb1	35	20	firm	firm	JJ
cord-295807-68sukdb1	35	21	conclusions	conclusion	NNS
cord-295807-68sukdb1	35	22	regarding	regard	VBG
cord-295807-68sukdb1	35	23	outcomes	outcome	NNS
cord-295807-68sukdb1	35	24	.	.	.
cord-295807-68sukdb1	36	1	For	for	IN
cord-295807-68sukdb1	36	2	these	these	DT
cord-295807-68sukdb1	36	3	reasons	reason	NNS
cord-295807-68sukdb1	36	4	it	-PRON-	PRP
cord-295807-68sukdb1	36	5	is	be	VBZ
cord-295807-68sukdb1	36	6	also	also	RB
cord-295807-68sukdb1	36	7	impossible	impossible	JJ
cord-295807-68sukdb1	36	8	to	to	TO
cord-295807-68sukdb1	36	9	extrapolate	extrapolate	VB
cord-295807-68sukdb1	36	10	findings	finding	NNS
cord-295807-68sukdb1	36	11	of	of	IN
cord-295807-68sukdb1	36	12	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	36	13	effectiveness	effectiveness	NN
cord-295807-68sukdb1	36	14	in	in	IN
cord-295807-68sukdb1	36	15	animal	animal	NN
cord-295807-68sukdb1	36	16	models	model	NNS
cord-295807-68sukdb1	36	17	and	and	CC
cord-295807-68sukdb1	36	18	limited	limited	JJ
cord-295807-68sukdb1	36	19	trials	trial	NNS
cord-295807-68sukdb1	36	20	into	into	IN
cord-295807-68sukdb1	36	21	an	an	DT
cord-295807-68sukdb1	36	22	assessment	assessment	NN
cord-295807-68sukdb1	36	23	of	of	IN
cord-295807-68sukdb1	36	24	general	general	JJ
cord-295807-68sukdb1	36	25	clinical	clinical	JJ
cord-295807-68sukdb1	36	26	utility	utility	NN
cord-295807-68sukdb1	36	27	.	.	.
cord-295807-68sukdb1	37	1	But	but	CC
cord-295807-68sukdb1	37	2	,	,	,
cord-295807-68sukdb1	37	3	in	in	IN
cord-295807-68sukdb1	37	4	as	as	RB
cord-295807-68sukdb1	37	5	much	much	JJ
cord-295807-68sukdb1	37	6	as	as	IN
cord-295807-68sukdb1	37	7	we	-PRON-	PRP
cord-295807-68sukdb1	37	8	are	be	VBP
cord-295807-68sukdb1	37	9	reporting	report	VBG
cord-295807-68sukdb1	37	10	potential	potential	NN
cord-295807-68sukdb1	37	11	,	,	,
cord-295807-68sukdb1	37	12	we	-PRON-	PRP
cord-295807-68sukdb1	37	13	have	have	VBP
cord-295807-68sukdb1	37	14	not	not	RB
cord-295807-68sukdb1	37	15	discounted	discount	VBN
cord-295807-68sukdb1	37	16	any	any	DT
cord-295807-68sukdb1	37	17	positive	positive	JJ
cord-295807-68sukdb1	37	18	outcomes	outcome	NNS
cord-295807-68sukdb1	37	19	.	.	.
cord-295807-68sukdb1	38	1	Finally	finally	RB
cord-295807-68sukdb1	38	2	,	,	,
cord-295807-68sukdb1	38	3	we	-PRON-	PRP
cord-295807-68sukdb1	38	4	note	note	VBP
cord-295807-68sukdb1	38	5	that	that	IN
cord-295807-68sukdb1	38	6	the	the	DT
cord-295807-68sukdb1	38	7	scope	scope	NN
cord-295807-68sukdb1	38	8	of	of	IN
cord-295807-68sukdb1	38	9	this	this	DT
cord-295807-68sukdb1	38	10	narrative	narrative	NN
cord-295807-68sukdb1	38	11	review	review	NN
cord-295807-68sukdb1	38	12	is	be	VBZ
cord-295807-68sukdb1	38	13	extremely	extremely	RB
cord-295807-68sukdb1	38	14	broad	broad	JJ
cord-295807-68sukdb1	38	15	and	and	CC
cord-295807-68sukdb1	38	16	the	the	DT
cord-295807-68sukdb1	38	17	literature	literature	NN
cord-295807-68sukdb1	38	18	is	be	VBZ
cord-295807-68sukdb1	38	19	extensive	extensive	JJ
cord-295807-68sukdb1	38	20	.	.	.
cord-295807-68sukdb1	39	1	For	for	IN
cord-295807-68sukdb1	39	2	this	this	DT
cord-295807-68sukdb1	39	3	reason	reason	NN
cord-295807-68sukdb1	39	4	,	,	,
cord-295807-68sukdb1	39	5	we	-PRON-	PRP
cord-295807-68sukdb1	39	6	have	have	VBP
cord-295807-68sukdb1	39	7	often	often	RB
cord-295807-68sukdb1	39	8	cited	cite	VBN
cord-295807-68sukdb1	39	9	reviews	review	NNS
cord-295807-68sukdb1	39	10	instead	instead	RB
cord-295807-68sukdb1	39	11	of	of	IN
cord-295807-68sukdb1	39	12	primary	primary	JJ
cord-295807-68sukdb1	39	13	literature	literature	NN
cord-295807-68sukdb1	39	14	in	in	IN
cord-295807-68sukdb1	39	15	order	order	NN
cord-295807-68sukdb1	39	16	to	to	TO
cord-295807-68sukdb1	39	17	simplify	simplify	VB
cord-295807-68sukdb1	39	18	the	the	DT
cord-295807-68sukdb1	39	19	document	document	NN
cord-295807-68sukdb1	39	20	and	and	CC
cord-295807-68sukdb1	39	21	provide	provide	VB
cord-295807-68sukdb1	39	22	a	a	DT
cord-295807-68sukdb1	39	23	cue	cue	NN
cord-295807-68sukdb1	39	24	to	to	IN
cord-295807-68sukdb1	39	25	further	further	JJ
cord-295807-68sukdb1	39	26	reading	reading	NN
cord-295807-68sukdb1	39	27	.	.	.
cord-295807-68sukdb1	40	1	We	-PRON-	PRP
cord-295807-68sukdb1	40	2	apologize	apologize	VBP
cord-295807-68sukdb1	40	3	in	in	IN
cord-295807-68sukdb1	40	4	advance	advance	NN
cord-295807-68sukdb1	40	5	to	to	IN
cord-295807-68sukdb1	40	6	any	any	DT
cord-295807-68sukdb1	40	7	authors	author	NNS
cord-295807-68sukdb1	40	8	whose	whose	WP$
cord-295807-68sukdb1	40	9	work	work	NN
cord-295807-68sukdb1	40	10	we	-PRON-	PRP
cord-295807-68sukdb1	40	11	have	have	VBP
cord-295807-68sukdb1	40	12	omitted	omit	VBN
cord-295807-68sukdb1	40	13	.	.	.
cord-295807-68sukdb1	41	1	The	the	DT
cord-295807-68sukdb1	41	2	maintenance	maintenance	NN
cord-295807-68sukdb1	41	3	of	of	IN
cord-295807-68sukdb1	41	4	blood	blood	NN
cord-295807-68sukdb1	41	5	pH	ph	NN
cord-295807-68sukdb1	41	6	in	in	IN
cord-295807-68sukdb1	41	7	the	the	DT
cord-295807-68sukdb1	41	8	face	face	NN
cord-295807-68sukdb1	41	9	of	of	IN
cord-295807-68sukdb1	41	10	a	a	DT
cord-295807-68sukdb1	41	11	~40	~40	XX
cord-295807-68sukdb1	41	12	-	-	HYPH
cord-295807-68sukdb1	41	13	70	70	CD
cord-295807-68sukdb1	41	14	mEq	mEq	NNS
cord-295807-68sukdb1	41	15	H	h	NN
cord-295807-68sukdb1	41	16	+	+	CC
cord-295807-68sukdb1	41	17	/day	/day	CD
cord-295807-68sukdb1	41	18	acid	acid	JJ
cord-295807-68sukdb1	41	19	load	load	NN
cord-295807-68sukdb1	41	20	imposed	impose	VBN
cord-295807-68sukdb1	41	21	by	by	IN
cord-295807-68sukdb1	41	22	diet	diet	NN
cord-295807-68sukdb1	41	23	and	and	CC
cord-295807-68sukdb1	41	24	metabolism	metabolism	NN
cord-295807-68sukdb1	41	25	(	(	-LRB-
cord-295807-68sukdb1	41	26	net	net	JJ
cord-295807-68sukdb1	41	27	endogenous	endogenous	JJ
cord-295807-68sukdb1	41	28	acid	acid	NN
cord-295807-68sukdb1	41	29	production	production	NN
cord-295807-68sukdb1	41	30	:	:	:
cord-295807-68sukdb1	41	31	NEAP	NEAP	NNP
cord-295807-68sukdb1	41	32	[	[	-LRB-
cord-295807-68sukdb1	41	33	2	2	CD
cord-295807-68sukdb1	41	34	,	,	,
cord-295807-68sukdb1	41	35	3	3	CD
cord-295807-68sukdb1	41	36	]	]	-RRB-
cord-295807-68sukdb1	41	37	)	)	-RRB-
cord-295807-68sukdb1	41	38	,	,	,
cord-295807-68sukdb1	41	39	requires	require	VBZ
cord-295807-68sukdb1	41	40	robust	robust	JJ
cord-295807-68sukdb1	41	41	homeostatic	homeostatic	JJ
cord-295807-68sukdb1	41	42	mechanisms	mechanism	NNS
cord-295807-68sukdb1	41	43	.	.	.
cord-295807-68sukdb1	42	1	Regulation	regulation	NN
cord-295807-68sukdb1	42	2	of	of	IN
cord-295807-68sukdb1	42	3	blood	blood	NN
cord-295807-68sukdb1	42	4	pH	ph	NN
cord-295807-68sukdb1	42	5	and	and	CC
cord-295807-68sukdb1	42	6	,	,	,
cord-295807-68sukdb1	42	7	by	by	IN
cord-295807-68sukdb1	42	8	extension	extension	NN
cord-295807-68sukdb1	42	9	,	,	,
cord-295807-68sukdb1	42	10	the	the	DT
cord-295807-68sukdb1	42	11	entire	entire	JJ
cord-295807-68sukdb1	42	12	extracellular	extracellular	JJ
cord-295807-68sukdb1	42	13	fluid	fluid	JJ
cord-295807-68sukdb1	42	14	compartment	compartment	NN
cord-295807-68sukdb1	42	15	depends	depend	VBZ
cord-295807-68sukdb1	42	16	on	on	IN
cord-295807-68sukdb1	42	17	the	the	DT
cord-295807-68sukdb1	42	18	interplay	interplay	NN
cord-295807-68sukdb1	42	19	between	between	IN
cord-295807-68sukdb1	42	20	(	(	-LRB-
cord-295807-68sukdb1	42	21	i	i	NN
cord-295807-68sukdb1	42	22	)	)	-RRB-
cord-295807-68sukdb1	42	23	the	the	DT
cord-295807-68sukdb1	42	24	urinary	urinary	JJ
cord-295807-68sukdb1	42	25	system	system	NN
cord-295807-68sukdb1	42	26	,	,	,
cord-295807-68sukdb1	42	27	which	which	WDT
cord-295807-68sukdb1	42	28	controls	control	VBZ
cord-295807-68sukdb1	42	29	the	the	DT
cord-295807-68sukdb1	42	30	blood	blood	NN
cord-295807-68sukdb1	42	31	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	42	32	concentration	concentration	NN
cord-295807-68sukdb1	42	33	(	(	-LRB-
cord-295807-68sukdb1	42	34	[	[	-LRB-
cord-295807-68sukdb1	42	35	HCO3	HCO3	NNP
cord-295807-68sukdb1	42	36	−	−	NNP
cord-295807-68sukdb1	42	37	]	]	-RRB-
cord-295807-68sukdb1	42	38	)	)	-RRB-
cord-295807-68sukdb1	42	39	,	,	,
cord-295807-68sukdb1	42	40	and	and	CC
cord-295807-68sukdb1	42	41	(	(	-LRB-
cord-295807-68sukdb1	42	42	ii	ii	NN
cord-295807-68sukdb1	42	43	)	)	-RRB-
cord-295807-68sukdb1	42	44	the	the	DT
cord-295807-68sukdb1	42	45	neuro	neuro	JJ
cord-295807-68sukdb1	42	46	-	-	HYPH
cord-295807-68sukdb1	42	47	respiratory	respiratory	JJ
cord-295807-68sukdb1	42	48	systems	system	NNS
cord-295807-68sukdb1	42	49	,	,	,
cord-295807-68sukdb1	42	50	which	which	WDT
cord-295807-68sukdb1	42	51	control	control	VBP
cord-295807-68sukdb1	42	52	the	the	DT
cord-295807-68sukdb1	42	53	partial	partial	JJ
cord-295807-68sukdb1	42	54	pressure	pressure	NN
cord-295807-68sukdb1	42	55	of	of	IN
cord-295807-68sukdb1	42	56	CO2	CO2	NNP
cord-295807-68sukdb1	42	57	(	(	-LRB-
cord-295807-68sukdb1	42	58	pCO2	pCO2	NNP
cord-295807-68sukdb1	42	59	,	,	,
cord-295807-68sukdb1	42	60	see	see	VB
cord-295807-68sukdb1	42	61	Figure	figure	NN
cord-295807-68sukdb1	42	62	1	1	CD
cord-295807-68sukdb1	42	63	)	)	-RRB-
cord-295807-68sukdb1	42	64	.	.	.
cord-295807-68sukdb1	43	1	The	the	DT
cord-295807-68sukdb1	43	2	kidneys	kidney	NNS
cord-295807-68sukdb1	43	3	perform	perform	VBP
cord-295807-68sukdb1	43	4	the	the	DT
cord-295807-68sukdb1	43	5	tasks	task	NNS
cord-295807-68sukdb1	43	6	of	of	IN
cord-295807-68sukdb1	43	7	generating	generate	VBG
cord-295807-68sukdb1	43	8	HCO3	HCO3	NNP
cord-295807-68sukdb1	43	9	-	-	HYPH
cord-295807-68sukdb1	43	10	,	,	,
cord-295807-68sukdb1	43	11	depositing	deposit	VBG
cord-295807-68sukdb1	43	12	it	-PRON-	PRP
cord-295807-68sukdb1	43	13	into	into	IN
cord-295807-68sukdb1	43	14	circulation	circulation	NN
cord-295807-68sukdb1	43	15	,	,	,
cord-295807-68sukdb1	43	16	and	and	CC
cord-295807-68sukdb1	43	17	recycling	recycle	VBG
cord-295807-68sukdb1	43	18	HCO3from	HCO3from	NNP
cord-295807-68sukdb1	43	19	filtered	filter	VBN
cord-295807-68sukdb1	43	20	plasma	plasma	NN
cord-295807-68sukdb1	43	21	back	back	RB
cord-295807-68sukdb1	43	22	into	into	IN
cord-295807-68sukdb1	43	23	circulation	circulation	NN
cord-295807-68sukdb1	43	24	(	(	-LRB-
cord-295807-68sukdb1	43	25	see	see	VB
cord-295807-68sukdb1	43	26	Figure	figure	NN
cord-295807-68sukdb1	43	27	2	2	CD
cord-295807-68sukdb1	43	28	)	)	-RRB-
cord-295807-68sukdb1	43	29	.	.	.
cord-295807-68sukdb1	44	1	The	the	DT
cord-295807-68sukdb1	44	2	lungs	lung	NNS
cord-295807-68sukdb1	44	3	exhale	exhale	VBP
cord-295807-68sukdb1	44	4	CO2	CO2	NNP
cord-295807-68sukdb1	44	5	,	,	,
cord-295807-68sukdb1	44	6	with	with	IN
cord-295807-68sukdb1	44	7	respiratory	respiratory	JJ
cord-295807-68sukdb1	44	8	drive	drive	NN
cord-295807-68sukdb1	44	9	being	be	VBG
cord-295807-68sukdb1	44	10	controlled	control	VBN
cord-295807-68sukdb1	44	11	by	by	IN
cord-295807-68sukdb1	44	12	chemosensitive	chemosensitive	JJ
cord-295807-68sukdb1	44	13	neural	neural	JJ
cord-295807-68sukdb1	44	14	circuitry	circuitry	NN
cord-295807-68sukdb1	44	15	[	[	-LRB-
cord-295807-68sukdb1	44	16	4	4	CD
cord-295807-68sukdb1	44	17	]	]	-RRB-
cord-295807-68sukdb1	44	18	.	.	.
cord-295807-68sukdb1	45	1	A	a	DT
cord-295807-68sukdb1	45	2	third	third	JJ
cord-295807-68sukdb1	45	3	mechanism	mechanism	NN
cord-295807-68sukdb1	45	4	of	of	IN
cord-295807-68sukdb1	45	5	defense	defense	NN
cord-295807-68sukdb1	45	6	,	,	,
cord-295807-68sukdb1	45	7	which	which	WDT
cord-295807-68sukdb1	45	8	does	do	VBZ
cord-295807-68sukdb1	45	9	not	not	RB
cord-295807-68sukdb1	45	10	exactly	exactly	RB
cord-295807-68sukdb1	45	11	regulate	regulate	VB
cord-295807-68sukdb1	45	12	pH	ph	NN
cord-295807-68sukdb1	45	13	but	but	CC
cord-295807-68sukdb1	45	14	only	only	RB
cord-295807-68sukdb1	45	15	tends	tend	VBZ
cord-295807-68sukdb1	45	16	to	to	TO
cord-295807-68sukdb1	45	17	minimize	minimize	VB
cord-295807-68sukdb1	45	18	its	-PRON-	PRP$
cord-295807-68sukdb1	45	19	changes	change	NNS
cord-295807-68sukdb1	45	20	,	,	,
cord-295807-68sukdb1	45	21	is	be	VBZ
cord-295807-68sukdb1	45	22	provided	provide	VBN
cord-295807-68sukdb1	45	23	by	by	IN
cord-295807-68sukdb1	45	24	the	the	DT
cord-295807-68sukdb1	45	25	multitude	multitude	NN
cord-295807-68sukdb1	45	26	of	of	IN
cord-295807-68sukdb1	45	27	buffer	buffer	NN
cord-295807-68sukdb1	45	28	systems	system	NNS
cord-295807-68sukdb1	45	29	present	present	JJ
cord-295807-68sukdb1	45	30	in	in	IN
cord-295807-68sukdb1	45	31	the	the	DT
cord-295807-68sukdb1	45	32	extracellular	extracellular	JJ
cord-295807-68sukdb1	45	33	fluid	fluid	JJ
cord-295807-68sukdb1	45	34	compartment	compartment	NN
cord-295807-68sukdb1	45	35	.	.	.
cord-295807-68sukdb1	46	1	Among	among	IN
cord-295807-68sukdb1	46	2	these	these	DT
cord-295807-68sukdb1	46	3	,	,	,
cord-295807-68sukdb1	46	4	the	the	DT
cord-295807-68sukdb1	46	5	most	most	RBS
cord-295807-68sukdb1	46	6	powerful	powerful	JJ
cord-295807-68sukdb1	46	7	is	be	VBZ
cord-295807-68sukdb1	46	8	the	the	DT
cord-295807-68sukdb1	46	9	CO2	CO2	NNP
cord-295807-68sukdb1	46	10	/	/	SYM
cord-295807-68sukdb1	46	11	HCO3	HCO3	NNP
cord-295807-68sukdb1	46	12	−	−	NNP
cord-295807-68sukdb1	46	13	buffer	buffer	NN
cord-295807-68sukdb1	46	14	system	system	NN
cord-295807-68sukdb1	46	15	,	,	,
cord-295807-68sukdb1	46	16	the	the	DT
cord-295807-68sukdb1	46	17	efficacy	efficacy	NN
cord-295807-68sukdb1	46	18	of	of	IN
cord-295807-68sukdb1	46	19	which	which	WDT
cord-295807-68sukdb1	46	20	is	be	VBZ
cord-295807-68sukdb1	46	21	conferred	confer	VBN
cord-295807-68sukdb1	46	22	by	by	IN
cord-295807-68sukdb1	46	23	the	the	DT
cord-295807-68sukdb1	46	24	body	body	NN
cord-295807-68sukdb1	46	25	behaving	behave	VBG
cord-295807-68sukdb1	46	26	as	as	IN
cord-295807-68sukdb1	46	27	an	an	DT
cord-295807-68sukdb1	46	28	open	open	JJ
cord-295807-68sukdb1	46	29	system	system	NN
cord-295807-68sukdb1	46	30	,	,	,
cord-295807-68sukdb1	46	31	with	with	IN
cord-295807-68sukdb1	46	32	respect	respect	NN
cord-295807-68sukdb1	46	33	to	to	IN
cord-295807-68sukdb1	46	34	CO2	CO2	NNP
cord-295807-68sukdb1	46	35	,	,	,
cord-295807-68sukdb1	46	36	from	from	IN
cord-295807-68sukdb1	46	37	which	which	WDT
cord-295807-68sukdb1	46	38	CO2	CO2	NNP
cord-295807-68sukdb1	46	39	can	can	MD
cord-295807-68sukdb1	46	40	escape	escape	VB
cord-295807-68sukdb1	46	41	[	[	-LRB-
cord-295807-68sukdb1	46	42	5	5	CD
cord-295807-68sukdb1	46	43	]	]	-RRB-
cord-295807-68sukdb1	46	44	.	.	.
cord-295807-68sukdb1	47	1	A	a	DT
cord-295807-68sukdb1	47	2	feature	feature	NN
cord-295807-68sukdb1	47	3	of	of	IN
cord-295807-68sukdb1	47	4	the	the	DT
cord-295807-68sukdb1	47	5	CO2	CO2	NNP
cord-295807-68sukdb1	47	6	/	/	SYM
cord-295807-68sukdb1	47	7	HCO3	HCO3	NNP
cord-295807-68sukdb1	47	8	−	−	NNP
cord-295807-68sukdb1	47	9	buffer	buffer	NN
cord-295807-68sukdb1	47	10	system	system	NN
cord-295807-68sukdb1	47	11	is	be	VBZ
cord-295807-68sukdb1	47	12	that	that	IN
cord-295807-68sukdb1	47	13	the	the	DT
cord-295807-68sukdb1	47	14	first	first	JJ
cord-295807-68sukdb1	47	15	of	of	IN
cord-295807-68sukdb1	47	16	the	the	DT
cord-295807-68sukdb1	47	17	two	two	CD
cord-295807-68sukdb1	47	18	-	-	HYPH
cord-295807-68sukdb1	47	19	step	step	NN
cord-295807-68sukdb1	47	20	reactions	reaction	NNS
cord-295807-68sukdb1	47	21	that	that	WDT
cord-295807-68sukdb1	47	22	describe	describe	VBP
cord-295807-68sukdb1	47	23	the	the	DT
cord-295807-68sukdb1	47	24	interconversion	interconversion	NN
cord-295807-68sukdb1	47	25	between	between	IN
cord-295807-68sukdb1	47	26	CO2	CO2	NNP
cord-295807-68sukdb1	47	27	and	and	CC
cord-295807-68sukdb1	47	28	HCO3	HCO3	NNP
cord-295807-68sukdb1	47	29	−	−	NNP
cord-295807-68sukdb1	48	1	(	(	-LRB-
cord-295807-68sukdb1	48	2	CO2	co2	NN
cord-295807-68sukdb1	48	3	+	+	CC
cord-295807-68sukdb1	49	1	H2O	H2O	NNP
cord-295807-68sukdb1	49	2	⇌	⇌	NNP
cord-295807-68sukdb1	49	3	H2CO3	H2CO3	NNP
cord-295807-68sukdb1	50	1	⇌	⇌	RB
cord-295807-68sukdb1	50	2	HCO3	HCO3	NNP
cord-295807-68sukdb1	50	3	−	−	NNP
cord-295807-68sukdb1	50	4	+	+	CC
cord-295807-68sukdb1	51	1	H	h	NN
cord-295807-68sukdb1	51	2	+	+	CC
cord-295807-68sukdb1	51	3	)	)	-RRB-
cord-295807-68sukdb1	51	4	is	be	VBZ
cord-295807-68sukdb1	51	5	very	very	RB
cord-295807-68sukdb1	51	6	slow	slow	JJ
cord-295807-68sukdb1	51	7	unless	unless	IN
cord-295807-68sukdb1	51	8	catalyzed	catalyze	VBN
cord-295807-68sukdb1	51	9	by	by	IN
cord-295807-68sukdb1	51	10	a	a	DT
cord-295807-68sukdb1	51	11	carbonic	carbonic	JJ
cord-295807-68sukdb1	51	12	anhydrase	anhydrase	NN
cord-295807-68sukdb1	51	13	(	(	-LRB-
cord-295807-68sukdb1	51	14	CA	CA	NNP
cord-295807-68sukdb1	51	15	)	)	-RRB-
cord-295807-68sukdb1	51	16	enzyme	enzyme	NN
cord-295807-68sukdb1	51	17	.	.	.
cord-295807-68sukdb1	52	1	Thus	thus	RB
cord-295807-68sukdb1	52	2	,	,	,
cord-295807-68sukdb1	52	3	efficient	efficient	JJ
cord-295807-68sukdb1	52	4	buffering	buffering	NN
cord-295807-68sukdb1	52	5	requires	require	VBZ
cord-295807-68sukdb1	52	6	the	the	DT
cord-295807-68sukdb1	52	7	presence	presence	NN
cord-295807-68sukdb1	52	8	of	of	IN
cord-295807-68sukdb1	52	9	a	a	DT
cord-295807-68sukdb1	52	10	CA	CA	NNP
cord-295807-68sukdb1	52	11	.	.	.
cord-295807-68sukdb1	53	1	The	the	DT
cord-295807-68sukdb1	53	2	Henderson	Henderson	NNP
cord-295807-68sukdb1	53	3	-	-	HYPH
cord-295807-68sukdb1	53	4	Hasselbalch	Hasselbalch	NNP
cord-295807-68sukdb1	53	5	equation	equation	NN
cord-295807-68sukdb1	53	6	[	[	-LRB-
cord-295807-68sukdb1	53	7	6	6	CD
cord-295807-68sukdb1	53	8	]	]	-RRB-
cord-295807-68sukdb1	53	9	describes	describe	VBZ
cord-295807-68sukdb1	53	10	how	how	WRB
cord-295807-68sukdb1	53	11	[	[	-LRB-
cord-295807-68sukdb1	53	12	HCO3	HCO3	NNP
cord-295807-68sukdb1	53	13	−	−	CD
cord-295807-68sukdb1	53	14	]	]	-RRB-
cord-295807-68sukdb1	53	15	and	and	CC
cord-295807-68sukdb1	53	16	pCO2	pCO2	NNP
cord-295807-68sukdb1	53	17	determine	determine	VB
cord-295807-68sukdb1	53	18	pH	ph	NN
cord-295807-68sukdb1	53	19	:	:	:
cord-295807-68sukdb1	54	1			NNS
cord-295807-68sukdb1	54	2			VBD
cord-295807-68sukdb1	54	3	2	2	CD
cord-295807-68sukdb1	54	4	3	3	CD
cord-295807-68sukdb1	54	5	CO	CO	NNP
cord-295807-68sukdb1	54	6	10	10	CD
cord-295807-68sukdb1	54	7	2	2	CD
cord-295807-68sukdb1	55	1	[	[	-LRB-
cord-295807-68sukdb1	55	2	HCO	HCO	NNP
cord-295807-68sukdb1	55	3	]	]	-RRB-
cord-295807-68sukdb1	56	1	pH	pH	NNP
cord-295807-68sukdb1	56	2	=	=	SYM
cord-295807-68sukdb1	56	3	p	p	NN
cord-295807-68sukdb1	56	4	+	+	CC
cord-295807-68sukdb1	56	5	log	log	NN
cord-295807-68sukdb1	56	6	.	.	.
cord-295807-68sukdb1	57	1	pCO	pCO	NNP
cord-295807-68sukdb1	57	2	K	K	NNP
cord-295807-68sukdb1	57	3	s	s	NNP
cord-295807-68sukdb1	57	4	Four	four	CD
cord-295807-68sukdb1	57	5	of	of	IN
cord-295807-68sukdb1	57	6	the	the	DT
cord-295807-68sukdb1	57	7	14	14	CD
cord-295807-68sukdb1	57	8	members	member	NNS
cord-295807-68sukdb1	57	9	of	of	IN
cord-295807-68sukdb1	57	10	the	the	DT
cord-295807-68sukdb1	57	11	monocarboxylate	monocarboxylate	NNP
cord-295807-68sukdb1	57	12	transporter	transporter	NN
cord-295807-68sukdb1	57	13	family	family	NN
cord-295807-68sukdb1	57	14	(	(	-LRB-
cord-295807-68sukdb1	57	15	MCTs	MCTs	NNP
cord-295807-68sukdb1	57	16	,	,	,
cord-295807-68sukdb1	57	17	SLC16A1	SLC16A1	NNP
cord-295807-68sukdb1	57	18	-	-	HYPH
cord-295807-68sukdb1	57	19	14	14	CD
cord-295807-68sukdb1	57	20	[	[	-LRB-
cord-295807-68sukdb1	57	21	30	30	CD
cord-295807-68sukdb1	57	22	]	]	-RRB-
cord-295807-68sukdb1	57	23	)	)	-RRB-
cord-295807-68sukdb1	57	24	are	be	VBP
cord-295807-68sukdb1	57	25	H	h	NN
cord-295807-68sukdb1	57	26	+	+	CC
cord-295807-68sukdb1	58	1	-coupled	-coupled	JJ
cord-295807-68sukdb1	58	2	lactate	lactate	NN
cord-295807-68sukdb1	58	3	transporters	transporter	NNS
cord-295807-68sukdb1	58	4	(	(	-LRB-
cord-295807-68sukdb1	58	5	MCT1	MCT1	NNP
cord-295807-68sukdb1	58	6	-	-	HYPH
cord-295807-68sukdb1	58	7	4	4	CD
cord-295807-68sukdb1	58	8	)	)	-RRB-
cord-295807-68sukdb1	58	9	.	.	.
cord-295807-68sukdb1	59	1	MCT1	MCT1	NNP
cord-295807-68sukdb1	59	2	and	and	CC
cord-295807-68sukdb1	59	3	MCT4	MCT4	NNP
cord-295807-68sukdb1	59	4	,	,	,
cord-295807-68sukdb1	59	5	being	be	VBG
cord-295807-68sukdb1	59	6	expressed	express	VBN
cord-295807-68sukdb1	59	7	in	in	IN
cord-295807-68sukdb1	59	8	tumors	tumor	NNS
cord-295807-68sukdb1	59	9	,	,	,
cord-295807-68sukdb1	59	10	are	be	VBP
cord-295807-68sukdb1	59	11	of	of	IN
cord-295807-68sukdb1	59	12	main	main	JJ
cord-295807-68sukdb1	59	13	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	59	14	interest	interest	NN
cord-295807-68sukdb1	59	15	.	.	.
cord-295807-68sukdb1	60	1	The	the	DT
cord-295807-68sukdb1	60	2	directionality	directionality	NN
cord-295807-68sukdb1	60	3	of	of	IN
cord-295807-68sukdb1	60	4	their	-PRON-	PRP$
cord-295807-68sukdb1	60	5	transport	transport	NN
cord-295807-68sukdb1	60	6	process	process	NN
cord-295807-68sukdb1	60	7	is	be	VBZ
cord-295807-68sukdb1	60	8	determined	determine	VBN
cord-295807-68sukdb1	60	9	by	by	IN
cord-295807-68sukdb1	60	10	kinetic	kinetic	JJ
cord-295807-68sukdb1	60	11	,	,	,
cord-295807-68sukdb1	60	12	thermodynamic	thermodynamic	JJ
cord-295807-68sukdb1	60	13	,	,	,
cord-295807-68sukdb1	60	14	and	and	CC
cord-295807-68sukdb1	60	15	situational	situational	JJ
cord-295807-68sukdb1	60	16	considerations	consideration	NNS
cord-295807-68sukdb1	60	17	;	;	:
cord-295807-68sukdb1	61	1	for	for	IN
cord-295807-68sukdb1	61	2	example	example	NN
cord-295807-68sukdb1	61	3	the	the	DT
cord-295807-68sukdb1	61	4	widely	widely	RB
cord-295807-68sukdb1	61	5	expressed	express	VBN
cord-295807-68sukdb1	61	6	isoform	isoform	NN
cord-295807-68sukdb1	61	7	MCT1	MCT1	NNP
cord-295807-68sukdb1	61	8	typically	typically	RB
cord-295807-68sukdb1	61	9	mediates	mediate	VBZ
cord-295807-68sukdb1	61	10	H	h	NN
cord-295807-68sukdb1	61	11	+	+	CC
cord-295807-68sukdb1	61	12	/Lacimport	/Lacimport	NNS
cord-295807-68sukdb1	61	13	,	,	,
cord-295807-68sukdb1	61	14	while	while	IN
cord-295807-68sukdb1	61	15	MCT4	MCT4	NNP
cord-295807-68sukdb1	61	16	,	,	,
cord-295807-68sukdb1	61	17	which	which	WDT
cord-295807-68sukdb1	61	18	is	be	VBZ
cord-295807-68sukdb1	61	19	abundantly	abundantly	RB
cord-295807-68sukdb1	61	20	expressed	express	VBN
cord-295807-68sukdb1	61	21	in	in	IN
cord-295807-68sukdb1	61	22	glycolytic	glycolytic	JJ
cord-295807-68sukdb1	61	23	(	(	-LRB-
cord-295807-68sukdb1	61	24	i.e.	i.e.	FW
cord-295807-68sukdb1	61	25	,	,	,
cord-295807-68sukdb1	61	26	lactate	lactate	NN
cord-295807-68sukdb1	61	27	-	-	HYPH
cord-295807-68sukdb1	61	28	producing	produce	VBG
cord-295807-68sukdb1	61	29	)	)	-RRB-
cord-295807-68sukdb1	61	30	cells	cell	NNS
cord-295807-68sukdb1	61	31	such	such	JJ
cord-295807-68sukdb1	61	32	as	as	IN
cord-295807-68sukdb1	61	33	cancer	cancer	NN
cord-295807-68sukdb1	61	34	cells	cell	NNS
cord-295807-68sukdb1	61	35	and	and	CC
cord-295807-68sukdb1	61	36	astrocytes	astrocyte	NNS
cord-295807-68sukdb1	61	37	,	,	,
cord-295807-68sukdb1	61	38	mediates	mediate	VBZ
cord-295807-68sukdb1	61	39	H	h	NN
cord-295807-68sukdb1	61	40	+	+	CC
cord-295807-68sukdb1	61	41	/Lacexport	/Lacexport	.
cord-295807-68sukdb1	62	1	[	[	-LRB-
cord-295807-68sukdb1	62	2	31	31	CD
cord-295807-68sukdb1	62	3	]	]	-RRB-
cord-295807-68sukdb1	62	4	.	.	.
cord-295807-68sukdb1	63	1	Members	member	NNS
cord-295807-68sukdb1	63	2	of	of	IN
cord-295807-68sukdb1	63	3	several	several	JJ
cord-295807-68sukdb1	63	4	other	other	JJ
cord-295807-68sukdb1	63	5	solute	solute	NN
cord-295807-68sukdb1	63	6	carrier	carrier	NN
cord-295807-68sukdb1	63	7	families	family	NNS
cord-295807-68sukdb1	63	8	also	also	RB
cord-295807-68sukdb1	63	9	cotransport	cotransport	VBP
cord-295807-68sukdb1	63	10	H	H	NNP
cord-295807-68sukdb1	63	11	+	+	CC
cord-295807-68sukdb1	63	12	with	with	IN
cord-295807-68sukdb1	63	13	their	-PRON-	PRP$
cord-295807-68sukdb1	63	14	substrates	substrate	NNS
cord-295807-68sukdb1	63	15	such	such	JJ
cord-295807-68sukdb1	63	16	as	as	IN
cord-295807-68sukdb1	63	17	the	the	DT
cord-295807-68sukdb1	63	18	H	H	NNP
cord-295807-68sukdb1	63	19	+	+	SYM
cord-295807-68sukdb1	63	20	-coupled	-coupled	CD
cord-295807-68sukdb1	63	21	oligopeptide	oligopeptide	JJ
cord-295807-68sukdb1	63	22	transporters	transporter	NNS
cord-295807-68sukdb1	63	23	of	of	IN
cord-295807-68sukdb1	63	24	the	the	DT
cord-295807-68sukdb1	63	25	SLC15	SLC15	NNP
cord-295807-68sukdb1	63	26	family	family	NN
cord-295807-68sukdb1	63	27	(	(	-LRB-
cord-295807-68sukdb1	63	28	e.g.	e.g.	RB
cord-295807-68sukdb1	63	29	,	,	,
cord-295807-68sukdb1	63	30	PeptT1	PeptT1	NNP
cord-295807-68sukdb1	63	31	[	[	-LRB-
cord-295807-68sukdb1	63	32	32	32	CD
cord-295807-68sukdb1	63	33	]	]	-RRB-
cord-295807-68sukdb1	63	34	)	)	-RRB-
cord-295807-68sukdb1	64	1	or	or	CC
cord-295807-68sukdb1	64	2	the	the	DT
cord-295807-68sukdb1	64	3	H	H	NNP
cord-295807-68sukdb1	64	4	+	+	SYM
cord-295807-68sukdb1	64	5	-coupled	-coupled	JJ
cord-295807-68sukdb1	64	6	neurotransmitter	neurotransmitter	NN
cord-295807-68sukdb1	64	7	transporters	transporter	NNS
cord-295807-68sukdb1	64	8	of	of	IN
cord-295807-68sukdb1	64	9	the	the	DT
cord-295807-68sukdb1	64	10	SLC1	SLC1	NNP
cord-295807-68sukdb1	64	11	family	family	NN
cord-295807-68sukdb1	64	12	(	(	-LRB-
cord-295807-68sukdb1	64	13	e.g.	e.g.	RB
cord-295807-68sukdb1	64	14	,	,	,
cord-295807-68sukdb1	64	15	the	the	DT
cord-295807-68sukdb1	64	16	excitatory	excitatory	JJ
cord-295807-68sukdb1	64	17	amino	amino	NN
cord-295807-68sukdb1	64	18	acid	acid	NN
cord-295807-68sukdb1	64	19	transporter	transporter	NN
cord-295807-68sukdb1	65	1	EAAT1	EAAT1	NNP
cord-295807-68sukdb1	65	2	[	[	-LRB-
cord-295807-68sukdb1	65	3	33	33	CD
cord-295807-68sukdb1	65	4	]	]	-RRB-
cord-295807-68sukdb1	65	5	)	)	-RRB-
cord-295807-68sukdb1	65	6	.	.	.
cord-295807-68sukdb1	66	1	The	the	DT
cord-295807-68sukdb1	66	2	MCT1	MCT1	NNP
cord-295807-68sukdb1	66	3	inhibitor	inhibitor	NN
cord-295807-68sukdb1	66	4	AZD3965	AZD3965	.
cord-295807-68sukdb1	67	1	[	[	-LRB-
cord-295807-68sukdb1	67	2	34	34	CD
cord-295807-68sukdb1	67	3	]	]	-RRB-
cord-295807-68sukdb1	67	4	is	be	VBZ
cord-295807-68sukdb1	67	5	currently	currently	RB
cord-295807-68sukdb1	67	6	in	in	IN
cord-295807-68sukdb1	67	7	Phase	phase	NN
cord-295807-68sukdb1	68	1	I	-PRON-	PRP
cord-295807-68sukdb1	68	2	clinical	clinical	JJ
cord-295807-68sukdb1	68	3	trial	trial	NN
cord-295807-68sukdb1	68	4	for	for	IN
cord-295807-68sukdb1	68	5	its	-PRON-	PRP$
cord-295807-68sukdb1	68	6	effectiveness	effectiveness	NN
cord-295807-68sukdb1	68	7	in	in	IN
cord-295807-68sukdb1	68	8	treating	treat	VBG
cord-295807-68sukdb1	68	9	cancer	cancer	NN
cord-295807-68sukdb1	68	10	(	(	-LRB-
cord-295807-68sukdb1	68	11	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-295807-68sukdb1	68	12	Identifier	Identifier	NNP
cord-295807-68sukdb1	68	13	:	:	:
cord-295807-68sukdb1	68	14	NCT01791595	NCT01791595	NNP
cord-295807-68sukdb1	68	15	)	)	-RRB-
cord-295807-68sukdb1	68	16	.	.	.
cord-295807-68sukdb1	69	1	There	there	EX
cord-295807-68sukdb1	69	2	are	be	VBP
cord-295807-68sukdb1	69	3	several	several	JJ
cord-295807-68sukdb1	69	4	membrane	membrane	NN
cord-295807-68sukdb1	69	5	proteins	protein	NNS
cord-295807-68sukdb1	69	6	that	that	WDT
cord-295807-68sukdb1	69	7	conduct	conduct	VBP
cord-295807-68sukdb1	69	8	H	h	NN
cord-295807-68sukdb1	69	9	+	+	CC
cord-295807-68sukdb1	69	10	but	but	CC
cord-295807-68sukdb1	69	11	share	share	VB
cord-295807-68sukdb1	69	12	no	no	DT
cord-295807-68sukdb1	69	13	obvious	obvious	JJ
cord-295807-68sukdb1	69	14	commonality	commonality	NN
cord-295807-68sukdb1	69	15	in	in	IN
cord-295807-68sukdb1	69	16	protein	protein	NN
cord-295807-68sukdb1	69	17	sequence	sequence	NN
cord-295807-68sukdb1	69	18	.	.	.
cord-295807-68sukdb1	70	1	One	one	CD
cord-295807-68sukdb1	70	2	group	group	NN
cord-295807-68sukdb1	70	3	act	act	NN
cord-295807-68sukdb1	70	4	as	as	IN
cord-295807-68sukdb1	70	5	H	H	NNP
cord-295807-68sukdb1	70	6	+	+	CC
cord-295807-68sukdb1	70	7	-selective	-selective	CD
cord-295807-68sukdb1	70	8	channels	channel	NNS
cord-295807-68sukdb1	70	9	and	and	CC
cord-295807-68sukdb1	70	10	include	include	VBP
cord-295807-68sukdb1	70	11	the	the	DT
cord-295807-68sukdb1	70	12	voltage	voltage	NN
cord-295807-68sukdb1	70	13	-	-	HYPH
cord-295807-68sukdb1	70	14	gated	gate	VBN
cord-295807-68sukdb1	70	15	H	h	NN
cord-295807-68sukdb1	70	16	+	+	CC
cord-295807-68sukdb1	70	17	channel	channel	NN
cord-295807-68sukdb1	70	18	HV1	HV1	NNP
cord-295807-68sukdb1	70	19	(	(	-LRB-
cord-295807-68sukdb1	70	20	HVCN1	HVCN1	NNP
cord-295807-68sukdb1	70	21	[	[	-LRB-
cord-295807-68sukdb1	70	22	35	35	CD
cord-295807-68sukdb1	70	23	]	]	-RRB-
cord-295807-68sukdb1	70	24	)	)	-RRB-
cord-295807-68sukdb1	71	1	and	and	CC
cord-295807-68sukdb1	71	2	the	the	DT
cord-295807-68sukdb1	71	3	voltage	voltage	NN
cord-295807-68sukdb1	71	4	-	-	HYPH
cord-295807-68sukdb1	71	5	independent	independent	JJ
cord-295807-68sukdb1	71	6	H	h	NN
cord-295807-68sukdb1	71	7	+	+	CC
cord-295807-68sukdb1	71	8	conductors	conductor	NNS
cord-295807-68sukdb1	71	9	SLC4A11	SLC4A11	.
cord-295807-68sukdb1	71	10	[	[	-LRB-
cord-295807-68sukdb1	71	11	36	36	CD
cord-295807-68sukdb1	71	12	]	]	-RRB-
cord-295807-68sukdb1	71	13	and	and	CC
cord-295807-68sukdb1	71	14	otopetrin	otopetrin	VBP
cord-295807-68sukdb1	71	15	1	1	CD
cord-295807-68sukdb1	71	16	(	(	-LRB-
cord-295807-68sukdb1	71	17	OTOP1	OTOP1	NNP
cord-295807-68sukdb1	71	18	[	[	-LRB-
cord-295807-68sukdb1	71	19	37	37	CD
cord-295807-68sukdb1	71	20	]	]	-RRB-
cord-295807-68sukdb1	71	21	)	)	-RRB-
cord-295807-68sukdb1	71	22	.	.	.
cord-295807-68sukdb1	72	1	All	all	DT
cord-295807-68sukdb1	72	2	permit	permit	VBP
cord-295807-68sukdb1	72	3	the	the	DT
cord-295807-68sukdb1	72	4	movement	movement	NN
cord-295807-68sukdb1	72	5	of	of	IN
cord-295807-68sukdb1	72	6	H	H	NNP
cord-295807-68sukdb1	72	7	+	+	CC
cord-295807-68sukdb1	72	8	down	down	IN
cord-295807-68sukdb1	72	9	their	-PRON-	PRP$
cord-295807-68sukdb1	72	10	transmembrane	transmembrane	NN
cord-295807-68sukdb1	72	11	electrochemical	electrochemical	JJ
cord-295807-68sukdb1	72	12	gradient	gradient	NN
cord-295807-68sukdb1	72	13	,	,	,
cord-295807-68sukdb1	72	14	but	but	CC
cord-295807-68sukdb1	72	15	each	each	DT
cord-295807-68sukdb1	72	16	differ	differ	VBP
cord-295807-68sukdb1	72	17	in	in	IN
cord-295807-68sukdb1	72	18	their	-PRON-	PRP$
cord-295807-68sukdb1	72	19	regulation	regulation	NN
cord-295807-68sukdb1	72	20	of	of	IN
cord-295807-68sukdb1	72	21	gating	gating	NN
cord-295807-68sukdb1	72	22	.	.	.
cord-295807-68sukdb1	73	1	HV1	HV1	NNP
cord-295807-68sukdb1	73	2	only	only	RB
cord-295807-68sukdb1	73	3	opens	open	VBZ
cord-295807-68sukdb1	73	4	when	when	WRB
cord-295807-68sukdb1	73	5	the	the	DT
cord-295807-68sukdb1	73	6	gradient	gradient	NN
cord-295807-68sukdb1	73	7	favors	favor	VBZ
cord-295807-68sukdb1	73	8	H	h	NN
cord-295807-68sukdb1	73	9	+	+	CC
cord-295807-68sukdb1	73	10	efflux	efflux	NN
cord-295807-68sukdb1	73	11	,	,	,
cord-295807-68sukdb1	73	12	SLC4A11	SLC4A11	NNP
cord-295807-68sukdb1	73	13	favors	favor	VBZ
cord-295807-68sukdb1	73	14	H	h	NN
cord-295807-68sukdb1	73	15	+	+	CC
cord-295807-68sukdb1	73	16	influx	influx	NN
cord-295807-68sukdb1	73	17	(	(	-LRB-
cord-295807-68sukdb1	73	18	particularly	particularly	RB
cord-295807-68sukdb1	73	19	at	at	IN
cord-295807-68sukdb1	73	20	elevated	elevated	JJ
cord-295807-68sukdb1	73	21	pHi	pHi	NNS
cord-295807-68sukdb1	73	22	[	[	-LRB-
cord-295807-68sukdb1	73	23	38	38	CD
cord-295807-68sukdb1	73	24	]	]	-RRB-
cord-295807-68sukdb1	73	25	,	,	,
cord-295807-68sukdb1	73	26	perhaps	perhaps	RB
cord-295807-68sukdb1	73	27	to	to	TO
cord-295807-68sukdb1	73	28	defend	defend	VB
cord-295807-68sukdb1	73	29	pHi	pHi	NNP
cord-295807-68sukdb1	73	30	)	)	-RRB-
cord-295807-68sukdb1	73	31	,	,	,
cord-295807-68sukdb1	73	32	and	and	CC
cord-295807-68sukdb1	73	33	OTOP1	otop1	NN
cord-295807-68sukdb1	73	34	also	also	RB
cord-295807-68sukdb1	73	35	favors	favor	VBZ
cord-295807-68sukdb1	73	36	H	h	NN
cord-295807-68sukdb1	73	37	+	+	CC
cord-295807-68sukdb1	73	38	influx	influx	NN
cord-295807-68sukdb1	73	39	(	(	-LRB-
cord-295807-68sukdb1	73	40	particularly	particularly	RB
cord-295807-68sukdb1	73	41	at	at	IN
cord-295807-68sukdb1	73	42	low	low	JJ
cord-295807-68sukdb1	73	43	pHe	phe	NN
cord-295807-68sukdb1	73	44	,	,	,
cord-295807-68sukdb1	73	45	perhaps	perhaps	RB
cord-295807-68sukdb1	73	46	consistent	consistent	JJ
cord-295807-68sukdb1	73	47	with	with	IN
cord-295807-68sukdb1	73	48	its	-PRON-	PRP$
cord-295807-68sukdb1	73	49	sensory	sensory	JJ
cord-295807-68sukdb1	73	50	role	role	NN
cord-295807-68sukdb1	73	51	)	)	-RRB-
cord-295807-68sukdb1	73	52	.	.	.
cord-295807-68sukdb1	74	1	In	in	IN
cord-295807-68sukdb1	74	2	acidotic	acidotic	JJ
cord-295807-68sukdb1	74	3	conditions	condition	NNS
cord-295807-68sukdb1	74	4	,	,	,
cord-295807-68sukdb1	74	5	the	the	DT
cord-295807-68sukdb1	74	6	transient	transient	JJ
cord-295807-68sukdb1	74	7	receptor	receptor	NN
cord-295807-68sukdb1	74	8	potential	potential	JJ
cord-295807-68sukdb1	74	9	cation	cation	NN
cord-295807-68sukdb1	74	10	channel	channel	NN
cord-295807-68sukdb1	74	11	subfamily	subfamily	NN
cord-295807-68sukdb1	74	12	V	V	NNP
cord-295807-68sukdb1	74	13	member	member	NN
cord-295807-68sukdb1	74	14	1	1	CD
cord-295807-68sukdb1	74	15	(	(	-LRB-
cord-295807-68sukdb1	74	16	TRPV1	TRPV1	NNP
cord-295807-68sukdb1	74	17	)	)	-RRB-
cord-295807-68sukdb1	74	18	can	can	MD
cord-295807-68sukdb1	74	19	also	also	RB
cord-295807-68sukdb1	74	20	mediate	mediate	VB
cord-295807-68sukdb1	74	21	a	a	DT
cord-295807-68sukdb1	74	22	significant	significant	JJ
cord-295807-68sukdb1	74	23	,	,	,
cord-295807-68sukdb1	74	24	but	but	CC
cord-295807-68sukdb1	74	25	non	non	JJ
cord-295807-68sukdb1	74	26	-	-	JJ
cord-295807-68sukdb1	74	27	canonical	canonical	JJ
cord-295807-68sukdb1	74	28	,	,	,
cord-295807-68sukdb1	74	29	acid	acid	NN
cord-295807-68sukdb1	74	30	-	-	HYPH
cord-295807-68sukdb1	74	31	loading	loading	NN
cord-295807-68sukdb1	74	32	H	h	NN
cord-295807-68sukdb1	74	33	+	+	CC
cord-295807-68sukdb1	74	34	conductance	conductance	NN
cord-295807-68sukdb1	74	35	[	[	-LRB-
cord-295807-68sukdb1	74	36	39	39	CD
cord-295807-68sukdb1	74	37	]	]	-RRB-
cord-295807-68sukdb1	74	38	.	.	.
cord-295807-68sukdb1	75	1	We	-PRON-	PRP
cord-295807-68sukdb1	75	2	are	be	VBP
cord-295807-68sukdb1	75	3	unaware	unaware	JJ
cord-295807-68sukdb1	75	4	of	of	IN
cord-295807-68sukdb1	75	5	any	any	DT
cord-295807-68sukdb1	75	6	FDA	FDA	NNP
cord-295807-68sukdb1	75	7	-	-	HYPH
cord-295807-68sukdb1	75	8	approvals	approval	NNS
cord-295807-68sukdb1	75	9	for	for	IN
cord-295807-68sukdb1	75	10	inhibition	inhibition	NN
cord-295807-68sukdb1	75	11	of	of	IN
cord-295807-68sukdb1	75	12	this	this	DT
cord-295807-68sukdb1	75	13	class	class	NN
cord-295807-68sukdb1	75	14	of	of	IN
cord-295807-68sukdb1	75	15	proteins	protein	NNS
cord-295807-68sukdb1	75	16	,	,	,
cord-295807-68sukdb1	75	17	with	with	IN
cord-295807-68sukdb1	75	18	the	the	DT
cord-295807-68sukdb1	75	19	exception	exception	NN
cord-295807-68sukdb1	75	20	of	of	IN
cord-295807-68sukdb1	75	21	TRPV1	TRPV1	NNP
cord-295807-68sukdb1	75	22	agonists	agonist	NNS
cord-295807-68sukdb1	75	23	whose	whose	WP$
cord-295807-68sukdb1	75	24	influence	influence	NN
cord-295807-68sukdb1	75	25	on	on	IN
cord-295807-68sukdb1	75	26	H	h	NN
cord-295807-68sukdb1	75	27	+	+	CC
cord-295807-68sukdb1	75	28	conductance	conductance	NN
cord-295807-68sukdb1	75	29	is	be	VBZ
cord-295807-68sukdb1	75	30	untested	untested	JJ
cord-295807-68sukdb1	75	31	.	.	.
cord-295807-68sukdb1	76	1	Although	although	IN
cord-295807-68sukdb1	76	2	there	there	EX
cord-295807-68sukdb1	76	3	is	be	VBZ
cord-295807-68sukdb1	76	4	no	no	DT
cord-295807-68sukdb1	76	5	description	description	NN
cord-295807-68sukdb1	76	6	of	of	IN
cord-295807-68sukdb1	76	7	a	a	DT
cord-295807-68sukdb1	76	8	HCO3	HCO3	NNP
cord-295807-68sukdb1	76	9	--specific	--specific	NN
cord-295807-68sukdb1	76	10	ion	ion	NN
cord-295807-68sukdb1	76	11	channel	channel	NN
cord-295807-68sukdb1	76	12	,	,	,
cord-295807-68sukdb1	76	13	several	several	JJ
cord-295807-68sukdb1	76	14	anion	anion	NN
cord-295807-68sukdb1	76	15	channels	channel	NNS
cord-295807-68sukdb1	76	16	have	have	VBP
cord-295807-68sukdb1	76	17	significant	significant	JJ
cord-295807-68sukdb1	76	18	HCO3permeability	hco3permeability	NN
cord-295807-68sukdb1	76	19	.	.	.
cord-295807-68sukdb1	77	1	The	the	DT
cord-295807-68sukdb1	77	2	electrochemical	electrochemical	JJ
cord-295807-68sukdb1	77	3	gradient	gradient	NN
cord-295807-68sukdb1	77	4	for	for	IN
cord-295807-68sukdb1	77	5	HCO3typically	HCO3typically	NNP
cord-295807-68sukdb1	77	6	favors	favor	VBZ
cord-295807-68sukdb1	77	7	HCO3	HCO3	NNP
cord-295807-68sukdb1	77	8	-efflux	-efflux	ADD
cord-295807-68sukdb1	77	9	.	.	.
cord-295807-68sukdb1	78	1	These	these	DT
cord-295807-68sukdb1	78	2	channels	channel	NNS
cord-295807-68sukdb1	78	3	include	include	VBP
cord-295807-68sukdb1	78	4	the	the	DT
cord-295807-68sukdb1	78	5	cystic	cystic	JJ
cord-295807-68sukdb1	78	6	fibrosis	fibrosis	NN
cord-295807-68sukdb1	78	7	transmembrane	transmembrane	NNP
cord-295807-68sukdb1	78	8	regulator	regulator	NN
cord-295807-68sukdb1	78	9	(	(	-LRB-
cord-295807-68sukdb1	78	10	CFTR	CFTR	NNP
cord-295807-68sukdb1	78	11	[	[	-LRB-
cord-295807-68sukdb1	78	12	40	40	CD
cord-295807-68sukdb1	78	13	]	]	-RRB-
cord-295807-68sukdb1	78	14	)	)	-RRB-
cord-295807-68sukdb1	78	15	,	,	,
cord-295807-68sukdb1	78	16	the	the	DT
cord-295807-68sukdb1	78	17	Ca	Ca	NNP
cord-295807-68sukdb1	78	18	2+activated	2+activated	NNP
cord-295807-68sukdb1	78	19	Cl	Cl	NNP
cord-295807-68sukdb1	78	20	--channel	--channel	NN
cord-295807-68sukdb1	78	21	anoctamin	anoctamin	NN
cord-295807-68sukdb1	78	22	1	1	CD
cord-295807-68sukdb1	79	1	(	(	-LRB-
cord-295807-68sukdb1	79	2	ANO1	ANO1	NNP
cord-295807-68sukdb1	79	3	[	[	-LRB-
cord-295807-68sukdb1	79	4	41	41	CD
cord-295807-68sukdb1	79	5	]	]	-RRB-
cord-295807-68sukdb1	79	6	)	)	-RRB-
cord-295807-68sukdb1	79	7	,	,	.
cord-295807-68sukdb1	80	1	as	as	RB
cord-295807-68sukdb1	80	2	well	well	RB
cord-295807-68sukdb1	80	3	GABA	GABA	NNP
cord-295807-68sukdb1	80	4	-	-	:
cord-295807-68sukdb1	80	5	and	and	CC
cord-295807-68sukdb1	80	6	glycine	glycine	NN
cord-295807-68sukdb1	80	7	-	-	HYPH
cord-295807-68sukdb1	80	8	activated	activate	VBN
cord-295807-68sukdb1	80	9	Cl	Cl	NNP
cord-295807-68sukdb1	80	10	-channels	-channels	NNP
cord-295807-68sukdb1	80	11	(	(	-LRB-
cord-295807-68sukdb1	80	12	GABR	GABR	NNP
cord-295807-68sukdb1	80	13	and	and	CC
cord-295807-68sukdb1	80	14	GLR	GLR	NNP
cord-295807-68sukdb1	80	15	families	family	NNS
cord-295807-68sukdb1	80	16	[	[	-LRB-
cord-295807-68sukdb1	80	17	42	42	CD
cord-295807-68sukdb1	80	18	]	]	-RRB-
cord-295807-68sukdb1	80	19	)	)	-RRB-
cord-295807-68sukdb1	80	20	.	.	.
cord-295807-68sukdb1	81	1	Drugs	drug	NNS
cord-295807-68sukdb1	81	2	such	such	JJ
cord-295807-68sukdb1	81	3	as	as	IN
cord-295807-68sukdb1	81	4	ivacaftor	ivacaftor	NN
cord-295807-68sukdb1	81	5	(	(	-LRB-
cord-295807-68sukdb1	81	6	KALYDECO	KALYDECO	NNP
cord-295807-68sukdb1	81	7	®	®	RBS
cord-295807-68sukdb1	81	8	,	,	,
cord-295807-68sukdb1	81	9	increases	increase	VBZ
cord-295807-68sukdb1	81	10	CFTR	CFTR	NNP
cord-295807-68sukdb1	81	11	channel	channel	VBP
cord-295807-68sukdb1	81	12	open	open	JJ
cord-295807-68sukdb1	81	13	probability	probability	NN
cord-295807-68sukdb1	81	14	)	)	-RRB-
cord-295807-68sukdb1	81	15	,	,	,
cord-295807-68sukdb1	81	16	or	or	CC
cord-295807-68sukdb1	81	17	cocktails	cocktail	NNS
cord-295807-68sukdb1	81	18	that	that	WDT
cord-295807-68sukdb1	81	19	include	include	VBP
cord-295807-68sukdb1	81	20	ivacaftor	ivacaftor	NN
cord-295807-68sukdb1	81	21	and	and	CC
cord-295807-68sukdb1	81	22	one	one	CD
cord-295807-68sukdb1	81	23	or	or	CC
cord-295807-68sukdb1	81	24	more	more	JJR
cord-295807-68sukdb1	81	25	of	of	IN
cord-295807-68sukdb1	81	26	the	the	DT
cord-295807-68sukdb1	81	27	CFTR	CFTR	NNP
cord-295807-68sukdb1	81	28	folding	fold	VBG
cord-295807-68sukdb1	81	29	chaperone	chaperone	NN
cord-295807-68sukdb1	81	30	drugs	drug	NNS
cord-295807-68sukdb1	81	31	elexacaftor	elexacaftor	NNP
cord-295807-68sukdb1	81	32	/	/	SYM
cord-295807-68sukdb1	81	33	lumacaftor	lumacaftor	NNP
cord-295807-68sukdb1	81	34	/	/	SYM
cord-295807-68sukdb1	81	35	tezacaftor	tezacaftor	NN
cord-295807-68sukdb1	81	36	(	(	-LRB-
cord-295807-68sukdb1	81	37	e.g.	e.g.	RB
cord-295807-68sukdb1	82	1	,	,	,
cord-295807-68sukdb1	82	2	ORKAMBI	ORKAMBI	NNP
cord-295807-68sukdb1	82	3	®	®	VBP
cord-295807-68sukdb1	82	4	,	,	,
cord-295807-68sukdb1	82	5	SYMDEKO	SYMDEKO	NNP
cord-295807-68sukdb1	82	6	®	®	NNP
cord-295807-68sukdb1	82	7	,	,	,
cord-295807-68sukdb1	82	8	TRIKAFTA	TRIKAFTA	NNP
cord-295807-68sukdb1	82	9	®	®	POS
cord-295807-68sukdb1	82	10	)	)	-RRB-
cord-295807-68sukdb1	82	11	are	be	VBP
cord-295807-68sukdb1	82	12	indicated	indicate	VBN
cord-295807-68sukdb1	82	13	for	for	IN
cord-295807-68sukdb1	82	14	the	the	DT
cord-295807-68sukdb1	82	15	treatment	treatment	NN
cord-295807-68sukdb1	82	16	of	of	IN
cord-295807-68sukdb1	82	17	cystic	cystic	JJ
cord-295807-68sukdb1	82	18	fibrosis	fibrosis	NN
cord-295807-68sukdb1	82	19	by	by	IN
cord-295807-68sukdb1	82	20	the	the	DT
cord-295807-68sukdb1	82	21	restoration	restoration	NN
cord-295807-68sukdb1	82	22	of	of	IN
cord-295807-68sukdb1	82	23	certain	certain	JJ
cord-295807-68sukdb1	82	24	defective	defective	JJ
cord-295807-68sukdb1	82	25	CFTR	CFTR	NNP
cord-295807-68sukdb1	82	26	channels	channel	NNS
cord-295807-68sukdb1	82	27	.	.	.
cord-295807-68sukdb1	83	1	Both	both	DT
cord-295807-68sukdb1	83	2	ivacaftor	ivacaftor	NN
cord-295807-68sukdb1	83	3	and	and	CC
cord-295807-68sukdb1	83	4	tezacaftor	tezacaftor	NN
cord-295807-68sukdb1	83	5	rescue	rescue	VB
cord-295807-68sukdb1	83	6	the	the	DT
cord-295807-68sukdb1	83	7	HCO3permeability	HCO3permeability	NNP
cord-295807-68sukdb1	83	8	of	of	IN
cord-295807-68sukdb1	83	9	the	the	DT
cord-295807-68sukdb1	83	10	Δ508-CFTR	δ508-cftr	NN
cord-295807-68sukdb1	83	11	mutant	mutant	NN
cord-295807-68sukdb1	83	12	.	.	.
cord-295807-68sukdb1	84	1	In	in	IN
cord-295807-68sukdb1	84	2	fact	fact	NN
cord-295807-68sukdb1	84	3	the	the	DT
cord-295807-68sukdb1	84	4	rescued	rescue	VBN
cord-295807-68sukdb1	84	5	mutant	mutant	NN
cord-295807-68sukdb1	84	6	has	have	VBZ
cord-295807-68sukdb1	84	7	a	a	DT
cord-295807-68sukdb1	84	8	greater	great	JJR
cord-295807-68sukdb1	84	9	HCO3	HCO3	NNP
cord-295807-68sukdb1	84	10	-:Clpermeability	-:clpermeability	NN
cord-295807-68sukdb1	84	11	ratio	ratio	NN
cord-295807-68sukdb1	84	12	than	than	IN
cord-295807-68sukdb1	84	13	wild	wild	JJ
cord-295807-68sukdb1	84	14	-	-	HYPH
cord-295807-68sukdb1	84	15	type	type	NN
cord-295807-68sukdb1	84	16	CFTR	CFTR	NNP
cord-295807-68sukdb1	84	17	,	,	,
cord-295807-68sukdb1	84	18	which	which	WDT
cord-295807-68sukdb1	84	19	may	may	MD
cord-295807-68sukdb1	84	20	be	be	VB
cord-295807-68sukdb1	84	21	therapeutically	therapeutically	RB
cord-295807-68sukdb1	84	22	valuable	valuable	JJ
cord-295807-68sukdb1	84	23	.	.	.
cord-295807-68sukdb1	85	1	The	the	DT
cord-295807-68sukdb1	85	2	importance	importance	NN
cord-295807-68sukdb1	85	3	of	of	IN
cord-295807-68sukdb1	85	4	CFTR	CFTR	NNP
cord-295807-68sukdb1	85	5	-	-	HYPH
cord-295807-68sukdb1	85	6	mediated	mediate	VBN
cord-295807-68sukdb1	85	7	HCO3secretion	HCO3secretion	NNP
cord-295807-68sukdb1	85	8	is	be	VBZ
cord-295807-68sukdb1	85	9	discussed	discuss	VBN
cord-295807-68sukdb1	85	10	in	in	IN
cord-295807-68sukdb1	85	11	sections	section	NNS
cord-295807-68sukdb1	85	12	4.3	4.3	CD
cord-295807-68sukdb1	85	13	The	the	DT
cord-295807-68sukdb1	85	14	Respiratory	Respiratory	NNP
cord-295807-68sukdb1	85	15	System	System	NNP
cord-295807-68sukdb1	85	16	,	,	,
cord-295807-68sukdb1	85	17	4.8	4.8	CD
cord-295807-68sukdb1	85	18	The	the	DT
cord-295807-68sukdb1	85	19	Lower	Lower	NNP
cord-295807-68sukdb1	85	20	Digestive	Digestive	NNP
cord-295807-68sukdb1	85	21	System	System	NNP
cord-295807-68sukdb1	85	22	,	,	,
cord-295807-68sukdb1	85	23	and	and	CC
cord-295807-68sukdb1	85	24	4.9	4.9	CD
cord-295807-68sukdb1	85	25	The	the	DT
cord-295807-68sukdb1	85	26	Urinary	Urinary	NNP
cord-295807-68sukdb1	85	27	System	System	NNP
cord-295807-68sukdb1	85	28	)	)	-RRB-
cord-295807-68sukdb1	85	29	.	.	.
cord-295807-68sukdb1	86	1	Five	five	CD
cord-295807-68sukdb1	86	2	of	of	IN
cord-295807-68sukdb1	86	3	the	the	DT
cord-295807-68sukdb1	86	4	ten	ten	CD
cord-295807-68sukdb1	86	5	members	member	NNS
cord-295807-68sukdb1	86	6	of	of	IN
cord-295807-68sukdb1	86	7	the	the	DT
cord-295807-68sukdb1	86	8	SLC4	SLC4	NNP
cord-295807-68sukdb1	86	9	family	family	NN
cord-295807-68sukdb1	86	10	of	of	IN
cord-295807-68sukdb1	86	11	proteins	protein	NNS
cord-295807-68sukdb1	86	12	mediate	mediate	VBP
cord-295807-68sukdb1	86	13	some	some	DT
cord-295807-68sukdb1	86	14	form	form	NN
cord-295807-68sukdb1	86	15	of	of	IN
cord-295807-68sukdb1	86	16	Na	Na	NNP
cord-295807-68sukdb1	86	17	+	+	CC
cord-295807-68sukdb1	86	18	-coupled	-couple	VBN
cord-295807-68sukdb1	87	1	HCO3	HCO3	NNP
cord-295807-68sukdb1	87	2	--transport	--transport	VBP
cord-295807-68sukdb1	87	3	[	[	-LRB-
cord-295807-68sukdb1	87	4	43	43	CD
cord-295807-68sukdb1	87	5	]	]	-RRB-
cord-295807-68sukdb1	87	6	.	.	.
cord-295807-68sukdb1	88	1	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	88	2	and	and	CC
cord-295807-68sukdb1	89	1	NBCe2	NBCe2	NNP
cord-295807-68sukdb1	89	2	(	(	-LRB-
cord-295807-68sukdb1	89	3	SLC4A4	SLC4A4	NNP
cord-295807-68sukdb1	89	4	and	and	CC
cord-295807-68sukdb1	89	5	SLC4A5	SLC4A5	NNP
cord-295807-68sukdb1	89	6	)	)	-RRB-
cord-295807-68sukdb1	89	7	are	be	VBP
cord-295807-68sukdb1	89	8	electrogenic	electrogenic	JJ
cord-295807-68sukdb1	89	9	Na	Na	NNP
cord-295807-68sukdb1	89	10	+	+	CC
cord-295807-68sukdb1	89	11	/2HCO3cotransporters	/2hco3cotransporter	NNS
cord-295807-68sukdb1	89	12	that	that	WDT
cord-295807-68sukdb1	89	13	may	may	MD
cord-295807-68sukdb1	89	14	either	either	RB
cord-295807-68sukdb1	89	15	act	act	VB
cord-295807-68sukdb1	89	16	as	as	IN
cord-295807-68sukdb1	89	17	acid	acid	NN
cord-295807-68sukdb1	89	18	-	-	HYPH
cord-295807-68sukdb1	89	19	extruders	extruder	NNS
cord-295807-68sukdb1	89	20	or	or	CC
cord-295807-68sukdb1	89	21	acid	acid	NN
cord-295807-68sukdb1	89	22	-	-	HYPH
cord-295807-68sukdb1	89	23	loaders	loader	NNS
cord-295807-68sukdb1	89	24	,	,	,
cord-295807-68sukdb1	89	25	depending	depend	VBG
cord-295807-68sukdb1	89	26	on	on	IN
cord-295807-68sukdb1	89	27	the	the	DT
cord-295807-68sukdb1	89	28	electrochemical	electrochemical	JJ
cord-295807-68sukdb1	89	29	gradient	gradient	NN
cord-295807-68sukdb1	89	30	.	.	.
cord-295807-68sukdb1	90	1	For	for	IN
cord-295807-68sukdb1	90	2	example	example	NN
cord-295807-68sukdb1	90	3	,	,	,
cord-295807-68sukdb1	90	4	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	90	5	mediates	mediate	VBZ
cord-295807-68sukdb1	90	6	HCO3efflux	HCO3efflux	NNP
cord-295807-68sukdb1	90	7	in	in	IN
cord-295807-68sukdb1	90	8	renal	renal	JJ
cord-295807-68sukdb1	90	9	proximal	proximal	JJ
cord-295807-68sukdb1	90	10	tubule	tubule	NN
cord-295807-68sukdb1	90	11	epithelia	epithelium	NNS
cord-295807-68sukdb1	90	12	,	,	,
cord-295807-68sukdb1	90	13	but	but	CC
cord-295807-68sukdb1	90	14	HCO3influx	HCO3influx	NNP
cord-295807-68sukdb1	90	15	in	in	IN
cord-295807-68sukdb1	90	16	pancreatic	pancreatic	JJ
cord-295807-68sukdb1	90	17	duct	duct	NN
cord-295807-68sukdb1	90	18	epithelia	epithelium	NNS
cord-295807-68sukdb1	90	19	.	.	.
cord-295807-68sukdb1	91	1	The	the	DT
cord-295807-68sukdb1	91	2	remaining	remain	VBG
cord-295807-68sukdb1	91	3	three	three	CD
cord-295807-68sukdb1	91	4	are	be	VBP
cord-295807-68sukdb1	91	5	all	all	DT
cord-295807-68sukdb1	91	6	acid	acid	NN
cord-295807-68sukdb1	91	7	extruders	extruder	NNS
cord-295807-68sukdb1	91	8	.	.	.
cord-295807-68sukdb1	92	1	NBCn1	NBCn1	NNP
cord-295807-68sukdb1	92	2	(	(	-LRB-
cord-295807-68sukdb1	92	3	SLC4A7	SLC4A7	NNP
cord-295807-68sukdb1	92	4	)	)	-RRB-
cord-295807-68sukdb1	92	5	is	be	VBZ
cord-295807-68sukdb1	92	6	an	an	DT
cord-295807-68sukdb1	92	7	electroneutral	electroneutral	NN
cord-295807-68sukdb1	93	1	Na	Na	NNP
cord-295807-68sukdb1	94	1	+	+	CC
cord-295807-68sukdb1	94	2	-HCO3cotransporter	-HCO3cotransporter	:
cord-295807-68sukdb1	94	3	,	,	,
cord-295807-68sukdb1	94	4	while	while	IN
cord-295807-68sukdb1	94	5	NDCBE	NDCBE	NNP
cord-295807-68sukdb1	94	6	(	(	-LRB-
cord-295807-68sukdb1	94	7	SLC4A8	SLC4A8	NNP
cord-295807-68sukdb1	94	8	)	)	-RRB-
cord-295807-68sukdb1	94	9	is	be	VBZ
cord-295807-68sukdb1	94	10	an	an	DT
cord-295807-68sukdb1	94	11	electroneutral	electroneutral	NN
cord-295807-68sukdb1	95	1	Na	Na	NNP
cord-295807-68sukdb1	95	2	+	+	CC
cord-295807-68sukdb1	96	1	-driven	-driven	NNP
cord-295807-68sukdb1	96	2	Cl	Cl	NNP
cord-295807-68sukdb1	96	3	-/HCO3exchanger	-/HCO3exchanger	NNP
cord-295807-68sukdb1	96	4	.	.	.
cord-295807-68sukdb1	97	1	NBCn2	NBCn2	NNP
cord-295807-68sukdb1	97	2	/	/	SYM
cord-295807-68sukdb1	97	3	NCBE	NCBE	NNP
cord-295807-68sukdb1	97	4	(	(	-LRB-
cord-295807-68sukdb1	97	5	SLC4A10	SLC4A10	NNP
cord-295807-68sukdb1	97	6	)	)	-RRB-
cord-295807-68sukdb1	97	7	has	have	VBZ
cord-295807-68sukdb1	97	8	been	be	VBN
cord-295807-68sukdb1	97	9	described	describe	VBN
cord-295807-68sukdb1	97	10	as	as	IN
cord-295807-68sukdb1	97	11	being	be	VBG
cord-295807-68sukdb1	97	12	capable	capable	JJ
cord-295807-68sukdb1	97	13	of	of	IN
cord-295807-68sukdb1	97	14	both	both	DT
cord-295807-68sukdb1	97	15	actions	action	NNS
cord-295807-68sukdb1	97	16	.	.	.
cord-295807-68sukdb1	98	1	We	-PRON-	PRP
cord-295807-68sukdb1	98	2	are	be	VBP
cord-295807-68sukdb1	98	3	unaware	unaware	JJ
cord-295807-68sukdb1	98	4	of	of	IN
cord-295807-68sukdb1	98	5	any	any	DT
cord-295807-68sukdb1	98	6	FDA	FDA	NNP
cord-295807-68sukdb1	98	7	-	-	HYPH
cord-295807-68sukdb1	98	8	approvals	approval	NNS
cord-295807-68sukdb1	98	9	for	for	IN
cord-295807-68sukdb1	98	10	inhibition	inhibition	NN
cord-295807-68sukdb1	98	11	of	of	IN
cord-295807-68sukdb1	98	12	this	this	DT
cord-295807-68sukdb1	98	13	class	class	NN
cord-295807-68sukdb1	98	14	of	of	IN
cord-295807-68sukdb1	98	15	proteins	protein	NNS
cord-295807-68sukdb1	98	16	,	,	,
cord-295807-68sukdb1	98	17	nor	nor	CC
cord-295807-68sukdb1	98	18	of	of	IN
cord-295807-68sukdb1	98	19	any	any	DT
cord-295807-68sukdb1	98	20	drug	drug	NN
cord-295807-68sukdb1	98	21	that	that	WDT
cord-295807-68sukdb1	98	22	is	be	VBZ
cord-295807-68sukdb1	98	23	specific	specific	JJ
cord-295807-68sukdb1	98	24	for	for	IN
cord-295807-68sukdb1	98	25	this	this	DT
cord-295807-68sukdb1	98	26	class	class	NN
cord-295807-68sukdb1	98	27	of	of	IN
cord-295807-68sukdb1	98	28	protein	protein	NN
cord-295807-68sukdb1	98	29	.	.	.
cord-295807-68sukdb1	99	1	We	-PRON-	PRP
cord-295807-68sukdb1	99	2	note	note	VBP
cord-295807-68sukdb1	99	3	however	however	RB
cord-295807-68sukdb1	99	4	that	that	IN
cord-295807-68sukdb1	99	5	the	the	DT
cord-295807-68sukdb1	99	6	nonsteroidal	nonsteroidal	JJ
cord-295807-68sukdb1	99	7	anti	anti	JJ
cord-295807-68sukdb1	99	8	-	-	JJ
cord-295807-68sukdb1	99	9	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	99	10	drug	drug	NN
cord-295807-68sukdb1	99	11	tenidap	tenidap	NNP
cord-295807-68sukdb1	99	12	,	,	,
cord-295807-68sukdb1	99	13	which	which	WDT
cord-295807-68sukdb1	99	14	failed	fail	VBD
cord-295807-68sukdb1	99	15	clinical	clinical	JJ
cord-295807-68sukdb1	99	16	trials	trial	NNS
cord-295807-68sukdb1	99	17	for	for	IN
cord-295807-68sukdb1	99	18	the	the	DT
cord-295807-68sukdb1	99	19	treatment	treatment	NN
cord-295807-68sukdb1	99	20	of	of	IN
cord-295807-68sukdb1	99	21	rheumatoid	rheumatoid	NN
cord-295807-68sukdb1	99	22	arthritis	arthritis	NN
cord-295807-68sukdb1	99	23	due	due	IN
cord-295807-68sukdb1	99	24	to	to	IN
cord-295807-68sukdb1	99	25	renal	renal	JJ
cord-295807-68sukdb1	99	26	and	and	CC
cord-295807-68sukdb1	99	27	hepatic	hepatic	JJ
cord-295807-68sukdb1	99	28	toxicity	toxicity	NN
cord-295807-68sukdb1	99	29	,	,	,
cord-295807-68sukdb1	99	30	is	be	VBZ
cord-295807-68sukdb1	99	31	an	an	DT
cord-295807-68sukdb1	99	32	effective	effective	JJ
cord-295807-68sukdb1	99	33	blocker	blocker	NN
cord-295807-68sukdb1	99	34	of	of	IN
cord-295807-68sukdb1	99	35	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	99	36	and	and	CC
cord-295807-68sukdb1	99	37	NBCe2	nbce2	XX
cord-295807-68sukdb1	99	38	[	[	-LRB-
cord-295807-68sukdb1	99	39	44,45	44,45	CD
cord-295807-68sukdb1	99	40	]	]	-RRB-
cord-295807-68sukdb1	99	41	.	.	.
cord-295807-68sukdb1	100	1	Equation	equation	NN
cord-295807-68sukdb1	100	2	(	(	-LRB-
cord-295807-68sukdb1	100	3	1	1	CD
cord-295807-68sukdb1	100	4	)	)	-RRB-
cord-295807-68sukdb1	100	5	and	and	CC
cord-295807-68sukdb1	100	6	Figure	figure	NN
cord-295807-68sukdb1	100	7	4	4	CD
cord-295807-68sukdb1	100	8	show	show	VBP
cord-295807-68sukdb1	100	9	that	that	IN
cord-295807-68sukdb1	100	10	,	,	,
cord-295807-68sukdb1	100	11	provided	provide	VBN
cord-295807-68sukdb1	100	12	that	that	IN
cord-295807-68sukdb1	100	13	pCO2	pCO2	NNP
cord-295807-68sukdb1	100	14	remains	remain	VBZ
cord-295807-68sukdb1	100	15	constant	constant	JJ
cord-295807-68sukdb1	100	16	,	,	,
cord-295807-68sukdb1	100	17	(	(	-LRB-
cord-295807-68sukdb1	100	18	i	i	NN
cord-295807-68sukdb1	100	19	)	)	-RRB-
cord-295807-68sukdb1	101	1	a	a	DT
cord-295807-68sukdb1	101	2	fall	fall	NN
cord-295807-68sukdb1	101	3	in	in	IN
cord-295807-68sukdb1	101	4	extracellular	extracellular	JJ
cord-295807-68sukdb1	101	5	[	[	-LRB-
cord-295807-68sukdb1	101	6	HCO3	HCO3	NNP
cord-295807-68sukdb1	101	7	−	−	NNP
cord-295807-68sukdb1	101	8	]	]	-RRB-
cord-295807-68sukdb1	101	9	causes	cause	VBZ
cord-295807-68sukdb1	101	10	pH	ph	NN
cord-295807-68sukdb1	101	11	to	to	TO
cord-295807-68sukdb1	101	12	decrease	decrease	VB
cord-295807-68sukdb1	101	13	whereas	whereas	IN
cord-295807-68sukdb1	101	14	(	(	-LRB-
cord-295807-68sukdb1	101	15	ii	ii	NN
cord-295807-68sukdb1	101	16	)	)	-RRB-
cord-295807-68sukdb1	101	17	a	a	DT
cord-295807-68sukdb1	101	18	rise	rise	NN
cord-295807-68sukdb1	101	19	in	in	IN
cord-295807-68sukdb1	101	20	extracellular	extracellular	JJ
cord-295807-68sukdb1	101	21	[	[	-LRB-
cord-295807-68sukdb1	101	22	HCO3	HCO3	NNP
cord-295807-68sukdb1	101	23	−	−	NNP
cord-295807-68sukdb1	101	24	]	]	-RRB-
cord-295807-68sukdb1	101	25	causes	cause	VBZ
cord-295807-68sukdb1	101	26	blood	blood	NN
cord-295807-68sukdb1	101	27	pH	ph	NN
cord-295807-68sukdb1	101	28	to	to	TO
cord-295807-68sukdb1	101	29	increase	increase	VB
cord-295807-68sukdb1	101	30	.	.	.
cord-295807-68sukdb1	102	1	These	these	DT
cord-295807-68sukdb1	102	2	two	two	CD
cord-295807-68sukdb1	102	3	cases	case	NNS
cord-295807-68sukdb1	102	4	describe	describe	VBP
cord-295807-68sukdb1	102	5	states	state	NNS
cord-295807-68sukdb1	102	6	of	of	IN
cord-295807-68sukdb1	102	7	metabolic	metabolic	JJ
cord-295807-68sukdb1	102	8	acidosis	acidosis	NN
cord-295807-68sukdb1	102	9	(	(	-LRB-
cord-295807-68sukdb1	102	10	MAc	MAc	NNP
cord-295807-68sukdb1	102	11	)	)	-RRB-
cord-295807-68sukdb1	102	12	and	and	CC
cord-295807-68sukdb1	102	13	metabolic	metabolic	JJ
cord-295807-68sukdb1	102	14	alkalosis	alkalosis	NN
cord-295807-68sukdb1	102	15	(	(	-LRB-
cord-295807-68sukdb1	102	16	MAlk	malk	CD
cord-295807-68sukdb1	102	17	)	)	-RRB-
cord-295807-68sukdb1	102	18	,	,	,
cord-295807-68sukdb1	102	19	respectively	respectively	RB
cord-295807-68sukdb1	102	20	.	.	.
cord-295807-68sukdb1	103	1	Equation	equation	NN
cord-295807-68sukdb1	103	2	(	(	-LRB-
cord-295807-68sukdb1	103	3	1	1	CD
cord-295807-68sukdb1	103	4	)	)	-RRB-
cord-295807-68sukdb1	103	5	also	also	RB
cord-295807-68sukdb1	103	6	indicates	indicate	VBZ
cord-295807-68sukdb1	103	7	that	that	IN
cord-295807-68sukdb1	103	8	pH	pH	NNP
cord-295807-68sukdb1	103	9	can	can	MD
cord-295807-68sukdb1	103	10	return	return	VB
cord-295807-68sukdb1	103	11	towards	towards	IN
cord-295807-68sukdb1	103	12	its	-PRON-	PRP$
cord-295807-68sukdb1	103	13	normal	normal	JJ
cord-295807-68sukdb1	103	14	physiological	physiological	JJ
cord-295807-68sukdb1	103	15	value	value	NN
cord-295807-68sukdb1	103	16	by	by	IN
cord-295807-68sukdb1	103	17	a	a	DT
cord-295807-68sukdb1	103	18	decrease	decrease	NN
cord-295807-68sukdb1	103	19	in	in	IN
cord-295807-68sukdb1	103	20	extracellular	extracellular	JJ
cord-295807-68sukdb1	103	21	pCO2	pCO2	NNP
cord-295807-68sukdb1	103	22	(	(	-LRB-
cord-295807-68sukdb1	103	23	in	in	IN
cord-295807-68sukdb1	103	24	case	case	NN
cord-295807-68sukdb1	103	25	'	'	``
cord-295807-68sukdb1	103	26	i	i	PRP
cord-295807-68sukdb1	103	27	'	'	''
cord-295807-68sukdb1	103	28	)	)	-RRB-
cord-295807-68sukdb1	103	29	or	or	CC
cord-295807-68sukdb1	103	30	an	an	DT
cord-295807-68sukdb1	103	31	increase	increase	NN
cord-295807-68sukdb1	103	32	in	in	IN
cord-295807-68sukdb1	103	33	extracellular	extracellular	JJ
cord-295807-68sukdb1	103	34	pCO2	pCO2	NNP
cord-295807-68sukdb1	103	35	(	(	-LRB-
cord-295807-68sukdb1	103	36	in	in	IN
cord-295807-68sukdb1	103	37	case	case	NN
cord-295807-68sukdb1	103	38	'	'	``
cord-295807-68sukdb1	103	39	ii	ii	NN
cord-295807-68sukdb1	103	40	'	'	''
cord-295807-68sukdb1	103	41	)	)	-RRB-
cord-295807-68sukdb1	103	42	.	.	.
cord-295807-68sukdb1	104	1	This	this	DT
cord-295807-68sukdb1	104	2	compensatory	compensatory	JJ
cord-295807-68sukdb1	104	3	normalization	normalization	NN
cord-295807-68sukdb1	104	4	of	of	IN
cord-295807-68sukdb1	104	5	the	the	DT
cord-295807-68sukdb1	104	6	[	[	-LRB-
cord-295807-68sukdb1	104	7	HCO3	HCO3	NNP
cord-295807-68sukdb1	104	8	-]:pCO2	-]:pCO2	NFP
cord-295807-68sukdb1	104	9	ratio	ratio	NN
cord-295807-68sukdb1	104	10	to	to	TO
cord-295807-68sukdb1	104	11	restore	restore	VB
cord-295807-68sukdb1	104	12	pH	pH	NNP
cord-295807-68sukdb1	104	13	,	,	,
cord-295807-68sukdb1	104	14	describes	describe	VBZ
cord-295807-68sukdb1	104	15	the	the	DT
cord-295807-68sukdb1	104	16	physiological	physiological	JJ
cord-295807-68sukdb1	104	17	response	response	NN
cord-295807-68sukdb1	104	18	of	of	IN
cord-295807-68sukdb1	104	19	the	the	DT
cord-295807-68sukdb1	104	20	neuro	neuro	JJ
cord-295807-68sukdb1	104	21	-	-	HYPH
cord-295807-68sukdb1	104	22	respiratory	respiratory	JJ
cord-295807-68sukdb1	104	23	system	system	NN
cord-295807-68sukdb1	104	24	to	to	IN
cord-295807-68sukdb1	104	25	MAc	MAc	NNP
cord-295807-68sukdb1	104	26	and	and	CC
cord-295807-68sukdb1	104	27	MAlk	MAlk	NNP
cord-295807-68sukdb1	104	28	.	.	.
cord-295807-68sukdb1	105	1	Moreover	moreover	RB
cord-295807-68sukdb1	105	2	,	,	,
cord-295807-68sukdb1	105	3	Equation	equation	NN
cord-295807-68sukdb1	105	4	(	(	-LRB-
cord-295807-68sukdb1	105	5	1	1	CD
cord-295807-68sukdb1	105	6	)	)	-RRB-
cord-295807-68sukdb1	105	7	and	and	CC
cord-295807-68sukdb1	105	8	Figure	figure	NN
cord-295807-68sukdb1	105	9	4	4	CD
cord-295807-68sukdb1	105	10	show	show	VBP
cord-295807-68sukdb1	105	11	that	that	IN
cord-295807-68sukdb1	105	12	,	,	,
cord-295807-68sukdb1	105	13	provided	provide	VBN
cord-295807-68sukdb1	105	14	that	that	IN
cord-295807-68sukdb1	105	15	[	[	-LRB-
cord-295807-68sukdb1	105	16	HCO3	HCO3	NNP
cord-295807-68sukdb1	105	17	-	-	,
cord-295807-68sukdb1	105	18	]	]	-RRB-
cord-295807-68sukdb1	105	19	remains	remain	VBZ
cord-295807-68sukdb1	105	20	constant	constant	JJ
cord-295807-68sukdb1	105	21	,	,	,
cord-295807-68sukdb1	105	22	(	(	-LRB-
cord-295807-68sukdb1	105	23	iii	iii	NN
cord-295807-68sukdb1	105	24	)	)	-RRB-
cord-295807-68sukdb1	106	1	a	a	DT
cord-295807-68sukdb1	106	2	rise	rise	NN
cord-295807-68sukdb1	106	3	in	in	IN
cord-295807-68sukdb1	106	4	extracellular	extracellular	JJ
cord-295807-68sukdb1	106	5	pCO2	pCO2	NNP
cord-295807-68sukdb1	106	6	causes	cause	VBZ
cord-295807-68sukdb1	106	7	blood	blood	NN
cord-295807-68sukdb1	106	8	pH	ph	NN
cord-295807-68sukdb1	106	9	to	to	TO
cord-295807-68sukdb1	106	10	decrease	decrease	VB
cord-295807-68sukdb1	106	11	whereas	whereas	IN
cord-295807-68sukdb1	106	12	(	(	-LRB-
cord-295807-68sukdb1	106	13	iv	iv	LS
cord-295807-68sukdb1	106	14	)	)	-RRB-
cord-295807-68sukdb1	106	15	a	a	DT
cord-295807-68sukdb1	106	16	decrease	decrease	NN
cord-295807-68sukdb1	106	17	in	in	IN
cord-295807-68sukdb1	106	18	extracellular	extracellular	JJ
cord-295807-68sukdb1	106	19	pCO2	pCO2	NNP
cord-295807-68sukdb1	106	20	causes	cause	VBZ
cord-295807-68sukdb1	106	21	blood	blood	NN
cord-295807-68sukdb1	106	22	pH	ph	NN
cord-295807-68sukdb1	106	23	to	to	TO
cord-295807-68sukdb1	106	24	rise	rise	VB
cord-295807-68sukdb1	106	25	.	.	.
cord-295807-68sukdb1	107	1	These	these	DT
cord-295807-68sukdb1	107	2	two	two	CD
cord-295807-68sukdb1	107	3	cases	case	NNS
cord-295807-68sukdb1	107	4	describe	describe	VBP
cord-295807-68sukdb1	107	5	states	state	NNS
cord-295807-68sukdb1	107	6	of	of	IN
cord-295807-68sukdb1	107	7	respiratory	respiratory	JJ
cord-295807-68sukdb1	107	8	acidosis	acidosis	NN
cord-295807-68sukdb1	107	9	(	(	-LRB-
cord-295807-68sukdb1	107	10	RAc	RAc	NNS
cord-295807-68sukdb1	107	11	)	)	-RRB-
cord-295807-68sukdb1	107	12	and	and	CC
cord-295807-68sukdb1	107	13	respiratory	respiratory	JJ
cord-295807-68sukdb1	107	14	alkalosis	alkalosis	NN
cord-295807-68sukdb1	107	15	(	(	-LRB-
cord-295807-68sukdb1	107	16	RAlk	RAlk	NNP
cord-295807-68sukdb1	107	17	)	)	-RRB-
cord-295807-68sukdb1	107	18	,	,	,
cord-295807-68sukdb1	107	19	respectively	respectively	RB
cord-295807-68sukdb1	107	20	.	.	.
cord-295807-68sukdb1	108	1	Again	again	RB
cord-295807-68sukdb1	108	2	,	,	,
cord-295807-68sukdb1	108	3	Equation	equation	NN
cord-295807-68sukdb1	108	4	(	(	-LRB-
cord-295807-68sukdb1	108	5	1	1	CD
cord-295807-68sukdb1	108	6	)	)	-RRB-
cord-295807-68sukdb1	108	7	indicates	indicate	VBZ
cord-295807-68sukdb1	108	8	that	that	IN
cord-295807-68sukdb1	108	9	pH	pH	NNP
cord-295807-68sukdb1	108	10	can	can	MD
cord-295807-68sukdb1	108	11	return	return	VB
cord-295807-68sukdb1	108	12	towards	towards	IN
cord-295807-68sukdb1	108	13	its	-PRON-	PRP$
cord-295807-68sukdb1	108	14	normal	normal	JJ
cord-295807-68sukdb1	108	15	value	value	NN
cord-295807-68sukdb1	108	16	by	by	IN
cord-295807-68sukdb1	108	17	an	an	DT
cord-295807-68sukdb1	108	18	increase	increase	NN
cord-295807-68sukdb1	108	19	(	(	-LRB-
cord-295807-68sukdb1	108	20	case	case	NN
cord-295807-68sukdb1	108	21	'	'	''
cord-295807-68sukdb1	108	22	iii	iii	NN
cord-295807-68sukdb1	108	23	'	'	''
cord-295807-68sukdb1	108	24	)	)	-RRB-
cord-295807-68sukdb1	108	25	or	or	CC
cord-295807-68sukdb1	108	26	decrease	decrease	VB
cord-295807-68sukdb1	108	27	(	(	-LRB-
cord-295807-68sukdb1	108	28	case	case	NN
cord-295807-68sukdb1	108	29	'	'	''
cord-295807-68sukdb1	108	30	iv	iv	NN
cord-295807-68sukdb1	108	31	'	'	''
cord-295807-68sukdb1	108	32	)	)	-RRB-
cord-295807-68sukdb1	108	33	in	in	IN
cord-295807-68sukdb1	108	34	extracellular	extracellular	JJ
cord-295807-68sukdb1	108	35	[	[	-LRB-
cord-295807-68sukdb1	108	36	HCO3	HCO3	NNP
cord-295807-68sukdb1	108	37	−	−	NNP
cord-295807-68sukdb1	108	38	]	]	-RRB-
cord-295807-68sukdb1	108	39	,	,	,
cord-295807-68sukdb1	108	40	describing	describe	VBG
cord-295807-68sukdb1	108	41	the	the	DT
cord-295807-68sukdb1	108	42	compensatory	compensatory	JJ
cord-295807-68sukdb1	108	43	physiological	physiological	JJ
cord-295807-68sukdb1	108	44	response	response	NN
cord-295807-68sukdb1	108	45	of	of	IN
cord-295807-68sukdb1	108	46	the	the	DT
cord-295807-68sukdb1	108	47	urinary	urinary	JJ
cord-295807-68sukdb1	108	48	system	system	NN
cord-295807-68sukdb1	108	49	to	to	IN
cord-295807-68sukdb1	108	50	RAc	RAc	NNS
cord-295807-68sukdb1	108	51	and	and	CC
cord-295807-68sukdb1	108	52	RAlk	RAlk	NNP
cord-295807-68sukdb1	108	53	.	.	.
cord-295807-68sukdb1	109	1	MAc	MAc	NNP
cord-295807-68sukdb1	109	2	,	,	,
cord-295807-68sukdb1	109	3	MAlk	MAlk	NNP
cord-295807-68sukdb1	109	4	,	,	,
cord-295807-68sukdb1	109	5	RAc	RAc	NNS
cord-295807-68sukdb1	109	6	,	,	,
cord-295807-68sukdb1	109	7	and	and	CC
cord-295807-68sukdb1	109	8	RAlk	ralk	NN
cord-295807-68sukdb1	109	9	are	be	VBP
cord-295807-68sukdb1	109	10	usually	usually	RB
cord-295807-68sukdb1	109	11	referred	refer	VBN
cord-295807-68sukdb1	109	12	to	to	IN
cord-295807-68sukdb1	109	13	as	as	IN
cord-295807-68sukdb1	109	14	the	the	DT
cord-295807-68sukdb1	109	15	four	four	CD
cord-295807-68sukdb1	109	16	classic	classic	JJ
cord-295807-68sukdb1	109	17	/	/	SYM
cord-295807-68sukdb1	109	18	simple	simple	JJ
cord-295807-68sukdb1	109	19	acid	acid	NN
cord-295807-68sukdb1	109	20	-	-	HYPH
cord-295807-68sukdb1	109	21	base	base	NN
cord-295807-68sukdb1	109	22	disturbances	disturbance	NNS
cord-295807-68sukdb1	109	23	.	.	.
cord-295807-68sukdb1	110	1	Respiratory	respiratory	JJ
cord-295807-68sukdb1	110	2	compensations	compensation	NNS
cord-295807-68sukdb1	110	3	usually	usually	RB
cord-295807-68sukdb1	110	4	occur	occur	VBP
cord-295807-68sukdb1	110	5	quite	quite	RB
cord-295807-68sukdb1	110	6	rapidly	rapidly	RB
cord-295807-68sukdb1	110	7	,	,	,
cord-295807-68sukdb1	110	8	within	within	IN
cord-295807-68sukdb1	110	9	an	an	DT
cord-295807-68sukdb1	110	10	hour	hour	NN
cord-295807-68sukdb1	110	11	of	of	IN
cord-295807-68sukdb1	110	12	the	the	DT
cord-295807-68sukdb1	110	13	appearance	appearance	NN
cord-295807-68sukdb1	110	14	of	of	IN
cord-295807-68sukdb1	110	15	the	the	DT
cord-295807-68sukdb1	110	16	metabolic	metabolic	JJ
cord-295807-68sukdb1	110	17	disorders	disorder	NNS
cord-295807-68sukdb1	110	18	and	and	CC
cord-295807-68sukdb1	110	19	are	be	VBP
cord-295807-68sukdb1	110	20	fully	fully	RB
cord-295807-68sukdb1	110	21	resolved	resolve	VBN
cord-295807-68sukdb1	110	22	within	within	IN
cord-295807-68sukdb1	110	23	12	12	CD
cord-295807-68sukdb1	110	24	to	to	TO
cord-295807-68sukdb1	110	25	36	36	CD
cord-295807-68sukdb1	110	26	hours	hour	NNS
cord-295807-68sukdb1	110	27	.	.	.
cord-295807-68sukdb1	111	1	In	in	IN
cord-295807-68sukdb1	111	2	contrast	contrast	NN
cord-295807-68sukdb1	111	3	,	,	,
cord-295807-68sukdb1	111	4	metabolic	metabolic	JJ
cord-295807-68sukdb1	111	5	responses	response	NNS
cord-295807-68sukdb1	111	6	to	to	IN
cord-295807-68sukdb1	111	7	respiratory	respiratory	JJ
cord-295807-68sukdb1	111	8	disorders	disorder	NNS
cord-295807-68sukdb1	111	9	occur	occur	VBP
cord-295807-68sukdb1	111	10	more	more	RBR
cord-295807-68sukdb1	111	11	slowly	slowly	RB
cord-295807-68sukdb1	111	12	and	and	CC
cord-295807-68sukdb1	111	13	may	may	MD
cord-295807-68sukdb1	111	14	take	take	VB
cord-295807-68sukdb1	111	15	up	up	RP
cord-295807-68sukdb1	111	16	to	to	IN
cord-295807-68sukdb1	111	17	several	several	JJ
cord-295807-68sukdb1	111	18	days	day	NNS
cord-295807-68sukdb1	111	19	to	to	TO
cord-295807-68sukdb1	111	20	fully	fully	RB
cord-295807-68sukdb1	111	21	resolve	resolve	VB
cord-295807-68sukdb1	111	22	as	as	IN
cord-295807-68sukdb1	111	23	they	-PRON-	PRP
cord-295807-68sukdb1	111	24	require	require	VBP
cord-295807-68sukdb1	111	25	remodeling	remodeling	NN
cord-295807-68sukdb1	111	26	of	of	IN
cord-295807-68sukdb1	111	27	acid	acid	NN
cord-295807-68sukdb1	111	28	-	-	HYPH
cord-295807-68sukdb1	111	29	base	base	NN
cord-295807-68sukdb1	111	30	handling	handling	NN
cord-295807-68sukdb1	111	31	mechanisms	mechanism	NNS
cord-295807-68sukdb1	111	32	in	in	IN
cord-295807-68sukdb1	111	33	the	the	DT
cord-295807-68sukdb1	111	34	urinary	urinary	JJ
cord-295807-68sukdb1	111	35	system	system	NN
cord-295807-68sukdb1	111	36	.	.	.
cord-295807-68sukdb1	112	1	The	the	DT
cord-295807-68sukdb1	112	2	most	most	RBS
cord-295807-68sukdb1	112	3	rapid	rapid	JJ
cord-295807-68sukdb1	112	4	response	response	NN
cord-295807-68sukdb1	112	5	-	-	:
cord-295807-68sukdb1	112	6	and	and	CC
cord-295807-68sukdb1	112	7	the	the	DT
cord-295807-68sukdb1	112	8	first	first	JJ
cord-295807-68sukdb1	112	9	line	line	NN
cord-295807-68sukdb1	112	10	of	of	IN
cord-295807-68sukdb1	112	11	defense	defense	NN
cord-295807-68sukdb1	112	12	of	of	IN
cord-295807-68sukdb1	112	13	our	-PRON-	PRP$
cord-295807-68sukdb1	112	14	body	body	NN
cord-295807-68sukdb1	112	15	-	-	:
cord-295807-68sukdb1	112	16	to	to	IN
cord-295807-68sukdb1	112	17	an	an	DT
cord-295807-68sukdb1	112	18	acid	acid	NN
cord-295807-68sukdb1	112	19	-	-	HYPH
cord-295807-68sukdb1	112	20	base	base	NN
cord-295807-68sukdb1	112	21	disorder	disorder	NN
cord-295807-68sukdb1	112	22	is	be	VBZ
cord-295807-68sukdb1	112	23	given	give	VBN
cord-295807-68sukdb1	112	24	by	by	IN
cord-295807-68sukdb1	112	25	chemical	chemical	NN
cord-295807-68sukdb1	112	26	buffering	buffering	NN
cord-295807-68sukdb1	112	27	which	which	WDT
cord-295807-68sukdb1	112	28	usually	usually	RB
cord-295807-68sukdb1	112	29	occurs	occur	VBZ
cord-295807-68sukdb1	112	30	within	within	IN
cord-295807-68sukdb1	112	31	minutes	minute	NNS
cord-295807-68sukdb1	112	32	.	.	.
cord-295807-68sukdb1	113	1	In	in	IN
cord-295807-68sukdb1	113	2	the	the	DT
cord-295807-68sukdb1	113	3	following	following	JJ
cord-295807-68sukdb1	113	4	four	four	CD
cord-295807-68sukdb1	113	5	sub	sub	NN
cord-295807-68sukdb1	113	6	-	-	HYPH
cord-295807-68sukdb1	113	7	sections	section	NNS
cord-295807-68sukdb1	113	8	we	-PRON-	PRP
cord-295807-68sukdb1	113	9	will	will	MD
cord-295807-68sukdb1	113	10	review	review	VB
cord-295807-68sukdb1	113	11	the	the	DT
cord-295807-68sukdb1	113	12	causes	cause	NNS
cord-295807-68sukdb1	113	13	,	,	,
cord-295807-68sukdb1	113	14	consequences	consequence	NNS
cord-295807-68sukdb1	113	15	,	,	,
cord-295807-68sukdb1	113	16	and	and	CC
cord-295807-68sukdb1	113	17	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	113	18	paradigms	paradigm	NNS
cord-295807-68sukdb1	113	19	for	for	IN
cord-295807-68sukdb1	113	20	each	each	DT
cord-295807-68sukdb1	113	21	of	of	IN
cord-295807-68sukdb1	113	22	the	the	DT
cord-295807-68sukdb1	113	23	four	four	CD
cord-295807-68sukdb1	113	24	systemic	systemic	JJ
cord-295807-68sukdb1	113	25	acid	acid	NN
cord-295807-68sukdb1	113	26	-	-	HYPH
cord-295807-68sukdb1	113	27	base	base	NN
cord-295807-68sukdb1	113	28	disturbances	disturbance	NNS
cord-295807-68sukdb1	113	29	.	.	.
cord-295807-68sukdb1	114	1	Several	several	JJ
cord-295807-68sukdb1	114	2	of	of	IN
cord-295807-68sukdb1	114	3	these	these	DT
cord-295807-68sukdb1	114	4	considerations	consideration	NNS
cord-295807-68sukdb1	114	5	are	be	VBP
cord-295807-68sukdb1	114	6	also	also	RB
cord-295807-68sukdb1	114	7	relevant	relevant	JJ
cord-295807-68sukdb1	114	8	to	to	IN
cord-295807-68sukdb1	114	9	the	the	DT
cord-295807-68sukdb1	114	10	resolution	resolution	NN
cord-295807-68sukdb1	114	11	of	of	IN
cord-295807-68sukdb1	114	12	local	local	JJ
cord-295807-68sukdb1	114	13	acid	acid	NN
cord-295807-68sukdb1	114	14	-	-	HYPH
cord-295807-68sukdb1	114	15	base	base	NN
cord-295807-68sukdb1	114	16	disturbances	disturbance	NNS
cord-295807-68sukdb1	114	17	and	and	CC
cord-295807-68sukdb1	114	18	will	will	MD
cord-295807-68sukdb1	114	19	be	be	VB
cord-295807-68sukdb1	114	20	revisited	revisit	VBN
cord-295807-68sukdb1	114	21	in	in	IN
cord-295807-68sukdb1	114	22	sections	section	NNS
cord-295807-68sukdb1	114	23	4	4	CD
cord-295807-68sukdb1	114	24	and	and	CC
cord-295807-68sukdb1	114	25	5	5	CD
cord-295807-68sukdb1	114	26	.	.	.
cord-295807-68sukdb1	115	1	For	for	IN
cord-295807-68sukdb1	115	2	a	a	DT
cord-295807-68sukdb1	115	3	more	more	RBR
cord-295807-68sukdb1	115	4	complete	complete	JJ
cord-295807-68sukdb1	115	5	and	and	CC
cord-295807-68sukdb1	115	6	clinical	clinical	JJ
cord-295807-68sukdb1	115	7	perspective	perspective	NN
cord-295807-68sukdb1	115	8	on	on	IN
cord-295807-68sukdb1	115	9	these	these	DT
cord-295807-68sukdb1	115	10	disturbances	disturbance	NNS
cord-295807-68sukdb1	115	11	in	in	IN
cord-295807-68sukdb1	115	12	isolation	isolation	NN
cord-295807-68sukdb1	115	13	,	,	,
cord-295807-68sukdb1	115	14	and	and	CC
cord-295807-68sukdb1	115	15	in	in	IN
cord-295807-68sukdb1	115	16	combination	combination	NN
cord-295807-68sukdb1	115	17	,	,	,
cord-295807-68sukdb1	115	18	we	-PRON-	PRP
cord-295807-68sukdb1	115	19	refer	refer	VBP
cord-295807-68sukdb1	115	20	the	the	DT
cord-295807-68sukdb1	115	21	reader	reader	NN
cord-295807-68sukdb1	115	22	to	to	TO
cord-295807-68sukdb1	115	23	reference	reference	VB
cord-295807-68sukdb1	115	24	[	[	-LRB-
cord-295807-68sukdb1	115	25	51	51	CD
cord-295807-68sukdb1	115	26	]	]	-RRB-
cord-295807-68sukdb1	115	27	.	.	.
cord-295807-68sukdb1	116	1	Metabolic	metabolic	JJ
cord-295807-68sukdb1	116	2	acidosis	acidosis	NN
cord-295807-68sukdb1	116	3	is	be	VBZ
cord-295807-68sukdb1	116	4	defined	define	VBN
cord-295807-68sukdb1	116	5	as	as	IN
cord-295807-68sukdb1	116	6	acidemia	acidemia	NN
cord-295807-68sukdb1	116	7	due	due	IN
cord-295807-68sukdb1	116	8	to	to	IN
cord-295807-68sukdb1	116	9	a	a	DT
cord-295807-68sukdb1	116	10	primary	primary	JJ
cord-295807-68sukdb1	116	11	pathological	pathological	JJ
cord-295807-68sukdb1	116	12	deficit	deficit	NN
cord-295807-68sukdb1	116	13	in	in	IN
cord-295807-68sukdb1	116	14	[	[	-LRB-
cord-295807-68sukdb1	116	15	HCO3	HCO3	NNP
cord-295807-68sukdb1	116	16	-	-	,
cord-295807-68sukdb1	116	17	]	]	-RRB-
cord-295807-68sukdb1	116	18	rather	rather	RB
cord-295807-68sukdb1	116	19	than	than	IN
cord-295807-68sukdb1	116	20	a	a	DT
cord-295807-68sukdb1	116	21	physiological	physiological	JJ
cord-295807-68sukdb1	116	22	,	,	,
cord-295807-68sukdb1	116	23	compensatory	compensatory	JJ
cord-295807-68sukdb1	116	24	lowering	lowering	NN
cord-295807-68sukdb1	116	25	of	of	IN
cord-295807-68sukdb1	116	26	[	[	-LRB-
cord-295807-68sukdb1	116	27	HCO3	HCO3	NNP
cord-295807-68sukdb1	116	28	-	-	,
cord-295807-68sukdb1	116	29	]	]	-RRB-
cord-295807-68sukdb1	116	30	in	in	IN
cord-295807-68sukdb1	116	31	response	response	NN
cord-295807-68sukdb1	116	32	to	to	IN
cord-295807-68sukdb1	116	33	respiratory	respiratory	JJ
cord-295807-68sukdb1	116	34	alkalosis	alkalosis	NN
cord-295807-68sukdb1	116	35	[	[	-LRB-
cord-295807-68sukdb1	116	36	52	52	CD
cord-295807-68sukdb1	116	37	]	]	-RRB-
cord-295807-68sukdb1	116	38	.	.	.
cord-295807-68sukdb1	117	1	The	the	DT
cord-295807-68sukdb1	117	2	body	body	NN
cord-295807-68sukdb1	117	3	can	can	MD
cord-295807-68sukdb1	117	4	counter	counter	VB
cord-295807-68sukdb1	117	5	acid	acid	NN
cord-295807-68sukdb1	117	6	shifts	shift	NNS
cord-295807-68sukdb1	117	7	in	in	IN
cord-295807-68sukdb1	117	8	plasma	plasma	NN
cord-295807-68sukdb1	117	9	pH	ph	NN
cord-295807-68sukdb1	117	10	in	in	IN
cord-295807-68sukdb1	117	11	the	the	DT
cord-295807-68sukdb1	117	12	short	short	JJ
cord-295807-68sukdb1	117	13	term	term	NN
cord-295807-68sukdb1	117	14	by	by	IN
cord-295807-68sukdb1	117	15	increasing	increase	VBG
cord-295807-68sukdb1	117	16	respiratory	respiratory	JJ
cord-295807-68sukdb1	117	17	drive	drive	NN
cord-295807-68sukdb1	117	18	to	to	TO
cord-295807-68sukdb1	117	19	lower	lower	VB
cord-295807-68sukdb1	117	20	CO2	CO2	NNP
cord-295807-68sukdb1	117	21	and	and	CC
cord-295807-68sukdb1	117	22	,	,	,
cord-295807-68sukdb1	117	23	in	in	IN
cord-295807-68sukdb1	117	24	the	the	DT
cord-295807-68sukdb1	117	25	longer	long	JJR
cord-295807-68sukdb1	117	26	term	term	NN
cord-295807-68sukdb1	117	27	,	,	,
cord-295807-68sukdb1	117	28	by	by	IN
cord-295807-68sukdb1	117	29	increasing	increase	VBG
cord-295807-68sukdb1	117	30	renal	renal	JJ
cord-295807-68sukdb1	117	31	H	h	NN
cord-295807-68sukdb1	117	32	+	+	CC
cord-295807-68sukdb1	117	33	excretion	excretion	NN
cord-295807-68sukdb1	117	34	/	/	SYM
cord-295807-68sukdb1	117	35	HCO3generation	HCO3generation	NNP
cord-295807-68sukdb1	117	36	.	.	.
cord-295807-68sukdb1	118	1	However	however	RB
cord-295807-68sukdb1	118	2	,	,	,
cord-295807-68sukdb1	118	3	if	if	IN
cord-295807-68sukdb1	118	4	these	these	DT
cord-295807-68sukdb1	118	5	compensatory	compensatory	JJ
cord-295807-68sukdb1	118	6	systems	system	NNS
cord-295807-68sukdb1	118	7	are	be	VBP
cord-295807-68sukdb1	118	8	defective	defective	JJ
cord-295807-68sukdb1	118	9	or	or	CC
cord-295807-68sukdb1	118	10	overwhelmed	overwhelmed	JJ
cord-295807-68sukdb1	118	11	,	,	,
cord-295807-68sukdb1	118	12	MAc	MAc	NNP
cord-295807-68sukdb1	118	13	will	will	MD
cord-295807-68sukdb1	118	14	result	result	VB
cord-295807-68sukdb1	118	15	.	.	.
cord-295807-68sukdb1	119	1	For	for	IN
cord-295807-68sukdb1	119	2	example	example	NN
cord-295807-68sukdb1	119	3	:	:	:
cord-295807-68sukdb1	119	4	MAc	MAc	NNP
cord-295807-68sukdb1	119	5	can	can	MD
cord-295807-68sukdb1	119	6	result	result	VB
cord-295807-68sukdb1	119	7	from	from	IN
cord-295807-68sukdb1	119	8	diet	diet	NN
cord-295807-68sukdb1	119	9	,	,	,
cord-295807-68sukdb1	119	10	chronic	chronic	JJ
cord-295807-68sukdb1	119	11	kidney	kidney	NN
cord-295807-68sukdb1	119	12	disease	disease	NN
cord-295807-68sukdb1	119	13	,	,	,
cord-295807-68sukdb1	119	14	and	and	CC
cord-295807-68sukdb1	119	15	diabetes	diabetes	NN
cord-295807-68sukdb1	119	16	(	(	-LRB-
cord-295807-68sukdb1	119	17	diabetic	diabetic	JJ
cord-295807-68sukdb1	119	18	ketoacidosis	ketoacidosis	NN
cord-295807-68sukdb1	119	19	)	)	-RRB-
cord-295807-68sukdb1	119	20	or	or	CC
cord-295807-68sukdb1	119	21	can	can	MD
cord-295807-68sukdb1	119	22	follow	follow	VB
cord-295807-68sukdb1	119	23	acute	acute	JJ
cord-295807-68sukdb1	119	24	myocardial	myocardial	JJ
cord-295807-68sukdb1	119	25	infarction	infarction	NN
cord-295807-68sukdb1	119	26	(	(	-LRB-
cord-295807-68sukdb1	119	27	lactic	lactic	JJ
cord-295807-68sukdb1	119	28	acidosis	acidosis	NN
cord-295807-68sukdb1	119	29	)	)	-RRB-
cord-295807-68sukdb1	119	30	,	,	,
cord-295807-68sukdb1	119	31	mutations	mutation	NNS
cord-295807-68sukdb1	119	32	in	in	IN
cord-295807-68sukdb1	119	33	renal	renal	JJ
cord-295807-68sukdb1	119	34	acid	acid	NN
cord-295807-68sukdb1	119	35	-	-	HYPH
cord-295807-68sukdb1	119	36	base	base	NN
cord-295807-68sukdb1	119	37	transporters	transporter	NNS
cord-295807-68sukdb1	119	38	(	(	-LRB-
cord-295807-68sukdb1	119	39	renal	renal	JJ
cord-295807-68sukdb1	119	40	tubular	tubular	JJ
cord-295807-68sukdb1	119	41	acidosis	acidosis	NN
cord-295807-68sukdb1	119	42	,	,	,
cord-295807-68sukdb1	119	43	see	see	VB
cord-295807-68sukdb1	119	44	section	section	NN
cord-295807-68sukdb1	119	45	4.9	4.9	CD
cord-295807-68sukdb1	119	46	)	)	-RRB-
cord-295807-68sukdb1	119	47	,	,	,
cord-295807-68sukdb1	119	48	intoxication	intoxication	NN
cord-295807-68sukdb1	119	49	with	with	IN
cord-295807-68sukdb1	119	50	compounds	compound	NNS
cord-295807-68sukdb1	119	51	(	(	-LRB-
cord-295807-68sukdb1	119	52	e.g.	e.g.	RB
cord-295807-68sukdb1	119	53	,	,	,
cord-295807-68sukdb1	119	54	aspirin	aspirin	NN
cord-295807-68sukdb1	119	55	)	)	-RRB-
cord-295807-68sukdb1	119	56	,	,	,
cord-295807-68sukdb1	119	57	and	and	CC
cord-295807-68sukdb1	119	58	diarrhea	diarrhea	NN
cord-295807-68sukdb1	119	59	(	(	-LRB-
cord-295807-68sukdb1	119	60	loss	loss	NN
cord-295807-68sukdb1	119	61	of	of	IN
cord-295807-68sukdb1	119	62	HCO3	HCO3	NNP
cord-295807-68sukdb1	119	63	--rich	--rich	JJ
cord-295807-68sukdb1	119	64	secretions	secretion	NNS
cord-295807-68sukdb1	119	65	)	)	-RRB-
cord-295807-68sukdb1	120	1	[	[	-LRB-
cord-295807-68sukdb1	120	2	53	53	CD
cord-295807-68sukdb1	120	3	]	]	-RRB-
cord-295807-68sukdb1	120	4	[	[	-LRB-
cord-295807-68sukdb1	120	5	54	54	CD
cord-295807-68sukdb1	120	6	]	]	-RRB-
cord-295807-68sukdb1	121	1	[	[	-LRB-
cord-295807-68sukdb1	121	2	55	55	CD
cord-295807-68sukdb1	121	3	]	]	-RRB-
cord-295807-68sukdb1	121	4	[	[	-LRB-
cord-295807-68sukdb1	121	5	56	56	CD
cord-295807-68sukdb1	121	6	]	]	-RRB-
cord-295807-68sukdb1	121	7	[	[	-LRB-
cord-295807-68sukdb1	121	8	57	57	CD
cord-295807-68sukdb1	121	9	]	]	-RRB-
cord-295807-68sukdb1	121	10	.	.	.
cord-295807-68sukdb1	122	1	Clinical	clinical	JJ
cord-295807-68sukdb1	122	2	manifestations	manifestation	NNS
cord-295807-68sukdb1	122	3	vary	vary	VBP
cord-295807-68sukdb1	122	4	depending	depend	VBG
cord-295807-68sukdb1	122	5	on	on	IN
cord-295807-68sukdb1	122	6	underlying	underlie	VBG
cord-295807-68sukdb1	122	7	cause	cause	NN
cord-295807-68sukdb1	122	8	,	,	,
cord-295807-68sukdb1	122	9	but	but	CC
cord-295807-68sukdb1	122	10	generally	generally	RB
cord-295807-68sukdb1	122	11	include	include	VBP
cord-295807-68sukdb1	122	12	weakness	weakness	NN
cord-295807-68sukdb1	122	13	,	,	,
cord-295807-68sukdb1	122	14	nausea	nausea	NN
cord-295807-68sukdb1	122	15	,	,	,
cord-295807-68sukdb1	122	16	and	and	CC
cord-295807-68sukdb1	122	17	flushed	flush	VBD
cord-295807-68sukdb1	122	18	skin	skin	NN
cord-295807-68sukdb1	122	19	[	[	-LRB-
cord-295807-68sukdb1	122	20	58	58	CD
cord-295807-68sukdb1	122	21	]	]	-RRB-
cord-295807-68sukdb1	122	22	.	.	.
cord-295807-68sukdb1	123	1	As	as	IN
cord-295807-68sukdb1	123	2	we	-PRON-	PRP
cord-295807-68sukdb1	123	3	shall	shall	MD
cord-295807-68sukdb1	123	4	see	see	VB
cord-295807-68sukdb1	123	5	,	,	,
cord-295807-68sukdb1	123	6	chronic	chronic	JJ
cord-295807-68sukdb1	123	7	MAc	MAc	NNP
cord-295807-68sukdb1	123	8	has	have	VBZ
cord-295807-68sukdb1	123	9	severe	severe	JJ
cord-295807-68sukdb1	123	10	consequences	consequence	NNS
cord-295807-68sukdb1	123	11	for	for	IN
cord-295807-68sukdb1	123	12	long	long	JJ
cord-295807-68sukdb1	123	13	-	-	HYPH
cord-295807-68sukdb1	123	14	term	term	NN
cord-295807-68sukdb1	123	15	health	health	NN
cord-295807-68sukdb1	123	16	.	.	.
cord-295807-68sukdb1	124	1	In	in	IN
cord-295807-68sukdb1	124	2	cases	case	NNS
cord-295807-68sukdb1	124	3	where	where	WRB
cord-295807-68sukdb1	124	4	MAc	MAc	NNP
cord-295807-68sukdb1	124	5	is	be	VBZ
cord-295807-68sukdb1	124	6	secondary	secondary	JJ
cord-295807-68sukdb1	124	7	to	to	IN
cord-295807-68sukdb1	124	8	another	another	DT
cord-295807-68sukdb1	124	9	disturbance	disturbance	NN
cord-295807-68sukdb1	124	10	such	such	JJ
cord-295807-68sukdb1	124	11	as	as	IN
cord-295807-68sukdb1	124	12	in	in	IN
cord-295807-68sukdb1	124	13	diabetes	diabetes	NN
cord-295807-68sukdb1	124	14	or	or	CC
cord-295807-68sukdb1	124	15	diarrhea	diarrhea	NN
cord-295807-68sukdb1	124	16	,	,	,
cord-295807-68sukdb1	124	17	treatment	treatment	NN
cord-295807-68sukdb1	124	18	of	of	IN
cord-295807-68sukdb1	124	19	the	the	DT
cord-295807-68sukdb1	124	20	underlying	underlying	JJ
cord-295807-68sukdb1	124	21	disorder	disorder	NN
cord-295807-68sukdb1	124	22	is	be	VBZ
cord-295807-68sukdb1	124	23	the	the	DT
cord-295807-68sukdb1	124	24	ultimate	ultimate	JJ
cord-295807-68sukdb1	124	25	goal	goal	NN
cord-295807-68sukdb1	124	26	.	.	.
cord-295807-68sukdb1	125	1	However	however	RB
cord-295807-68sukdb1	125	2	,	,	,
cord-295807-68sukdb1	125	3	for	for	IN
cord-295807-68sukdb1	125	4	short	short	JJ
cord-295807-68sukdb1	125	5	term	term	NN
cord-295807-68sukdb1	125	6	remediation	remediation	NN
cord-295807-68sukdb1	125	7	of	of	IN
cord-295807-68sukdb1	125	8	MAc	MAc	NNP
cord-295807-68sukdb1	125	9	,	,	,
cord-295807-68sukdb1	125	10	or	or	CC
cord-295807-68sukdb1	125	11	for	for	IN
cord-295807-68sukdb1	125	12	situations	situation	NNS
cord-295807-68sukdb1	125	13	in	in	IN
cord-295807-68sukdb1	125	14	which	which	WDT
cord-295807-68sukdb1	125	15	the	the	DT
cord-295807-68sukdb1	125	16	primary	primary	JJ
cord-295807-68sukdb1	125	17	defect	defect	NN
cord-295807-68sukdb1	125	18	is	be	VBZ
cord-295807-68sukdb1	125	19	with	with	IN
cord-295807-68sukdb1	125	20	acid	acid	NN
cord-295807-68sukdb1	125	21	-	-	HYPH
cord-295807-68sukdb1	125	22	base	base	NN
cord-295807-68sukdb1	125	23	homeostatic	homeostatic	JJ
cord-295807-68sukdb1	125	24	mechanisms	mechanism	NNS
cord-295807-68sukdb1	125	25	,	,	,
cord-295807-68sukdb1	125	26	the	the	DT
cord-295807-68sukdb1	125	27	typical	typical	JJ
cord-295807-68sukdb1	125	28	course	course	NN
cord-295807-68sukdb1	125	29	of	of	IN
cord-295807-68sukdb1	125	30	action	action	NN
cord-295807-68sukdb1	125	31	is	be	VBZ
cord-295807-68sukdb1	125	32	'	'	``
cord-295807-68sukdb1	125	33	alkali	alkali	NN
cord-295807-68sukdb1	125	34	therapy	therapy	NN
cord-295807-68sukdb1	125	35	'	'	''
cord-295807-68sukdb1	125	36	to	to	TO
cord-295807-68sukdb1	125	37	address	address	VB
cord-295807-68sukdb1	125	38	MAc	MAc	NNP
cord-295807-68sukdb1	125	39	by	by	IN
cord-295807-68sukdb1	125	40	normalizing	normalize	VBG
cord-295807-68sukdb1	125	41	plasma	plasma	NN
cord-295807-68sukdb1	125	42	pH.	ph.	NN
cord-295807-68sukdb1	126	1	This	this	DT
cord-295807-68sukdb1	126	2	can	can	MD
cord-295807-68sukdb1	126	3	be	be	VB
cord-295807-68sukdb1	126	4	achieved	achieve	VBN
cord-295807-68sukdb1	126	5	via	via	IN
cord-295807-68sukdb1	126	6	two	two	CD
cord-295807-68sukdb1	126	7	mechanisms	mechanism	NNS
cord-295807-68sukdb1	126	8	.	.	.
cord-295807-68sukdb1	127	1	The	the	DT
cord-295807-68sukdb1	127	2	following	following	JJ
cord-295807-68sukdb1	127	3	paragraph	paragraph	NN
cord-295807-68sukdb1	127	4	describes	describe	VBZ
cord-295807-68sukdb1	127	5	therapies	therapy	NNS
cord-295807-68sukdb1	127	6	that	that	WDT
cord-295807-68sukdb1	127	7	increase	increase	VBP
cord-295807-68sukdb1	127	8	base	base	NN
cord-295807-68sukdb1	127	9	load	load	NN
cord-295807-68sukdb1	127	10	while	while	IN
cord-295807-68sukdb1	127	11	the	the	DT
cord-295807-68sukdb1	127	12	final	final	JJ
cord-295807-68sukdb1	127	13	paragraph	paragraph	NN
cord-295807-68sukdb1	127	14	describes	describe	VBZ
cord-295807-68sukdb1	127	15	therapies	therapy	NNS
cord-295807-68sukdb1	127	16	that	that	WDT
cord-295807-68sukdb1	127	17	lower	lower	VBP
cord-295807-68sukdb1	127	18	acid	acid	NN
cord-295807-68sukdb1	127	19	load	load	NN
cord-295807-68sukdb1	127	20	.	.	.
cord-295807-68sukdb1	128	1	Increasing	increase	VBG
cord-295807-68sukdb1	128	2	base	base	NN
cord-295807-68sukdb1	128	3	load	load	NN
cord-295807-68sukdb1	128	4	.	.	.
cord-295807-68sukdb1	129	1	The	the	DT
cord-295807-68sukdb1	129	2	simplest	simple	JJS
cord-295807-68sukdb1	129	3	paradigm	paradigm	NN
cord-295807-68sukdb1	129	4	is	be	VBZ
cord-295807-68sukdb1	129	5	administration	administration	NN
cord-295807-68sukdb1	129	6	of	of	IN
cord-295807-68sukdb1	129	7	HCO3salts	HCO3salts	NNP
cord-295807-68sukdb1	129	8	.	.	.
cord-295807-68sukdb1	130	1	A	a	DT
cord-295807-68sukdb1	130	2	direct	direct	JJ
cord-295807-68sukdb1	130	3	rise	rise	NN
cord-295807-68sukdb1	130	4	in	in	IN
cord-295807-68sukdb1	130	5	plasma	plasma	NN
cord-295807-68sukdb1	130	6	[	[	-LRB-
cord-295807-68sukdb1	130	7	HCO3	HCO3	NNP
cord-295807-68sukdb1	130	8	-	-	,
cord-295807-68sukdb1	130	9	]	]	-RRB-
cord-295807-68sukdb1	130	10	can	can	MD
cord-295807-68sukdb1	130	11	be	be	VB
cord-295807-68sukdb1	130	12	achieved	achieve	VBN
cord-295807-68sukdb1	130	13	either	either	CC
cord-295807-68sukdb1	130	14	intravenously	intravenously	RB
cord-295807-68sukdb1	130	15	or	or	CC
cord-295807-68sukdb1	130	16	by	by	IN
cord-295807-68sukdb1	130	17	peritoneal	peritoneal	JJ
cord-295807-68sukdb1	130	18	dialysis	dialysis	NN
cord-295807-68sukdb1	130	19	.	.	.
cord-295807-68sukdb1	131	1	An	an	DT
cord-295807-68sukdb1	131	2	indirect	indirect	JJ
cord-295807-68sukdb1	131	3	rise	rise	NN
cord-295807-68sukdb1	131	4	in	in	IN
cord-295807-68sukdb1	131	5	plasma	plasma	NN
cord-295807-68sukdb1	131	6	[	[	-LRB-
cord-295807-68sukdb1	131	7	HCO3	HCO3	NNP
cord-295807-68sukdb1	131	8	-	-	,
cord-295807-68sukdb1	131	9	]	]	-RRB-
cord-295807-68sukdb1	131	10	can	can	MD
cord-295807-68sukdb1	131	11	be	be	VB
cord-295807-68sukdb1	131	12	achieved	achieve	VBN
cord-295807-68sukdb1	131	13	by	by	IN
cord-295807-68sukdb1	131	14	oral	oral	JJ
cord-295807-68sukdb1	131	15	dosing	dosing	NN
cord-295807-68sukdb1	131	16	;	;	:
cord-295807-68sukdb1	131	17	as	as	IN
cord-295807-68sukdb1	131	18	the	the	DT
cord-295807-68sukdb1	131	19	parietal	parietal	JJ
cord-295807-68sukdb1	131	20	cells	cell	NNS
cord-295807-68sukdb1	131	21	of	of	IN
cord-295807-68sukdb1	131	22	the	the	DT
cord-295807-68sukdb1	131	23	stomach	stomach	NN
cord-295807-68sukdb1	131	24	replace	replace	NN
cord-295807-68sukdb1	131	25	neutralized	neutralize	VBN
cord-295807-68sukdb1	131	26	stomach	stomach	NN
cord-295807-68sukdb1	131	27	acid	acid	NN
cord-295807-68sukdb1	131	28	,	,	,
cord-295807-68sukdb1	131	29	they	-PRON-	PRP
cord-295807-68sukdb1	131	30	also	also	RB
cord-295807-68sukdb1	131	31	generate	generate	VBP
cord-295807-68sukdb1	131	32	new	new	JJ
cord-295807-68sukdb1	131	33	HCO3	HCO3	NNP
cord-295807-68sukdb1	131	34	-	-	HYPH
cord-295807-68sukdb1	131	35	,	,	,
cord-295807-68sukdb1	131	36	which	which	WDT
cord-295807-68sukdb1	131	37	is	be	VBZ
cord-295807-68sukdb1	131	38	absorbed	absorb	VBN
cord-295807-68sukdb1	131	39	into	into	IN
cord-295807-68sukdb1	131	40	circulation	circulation	NN
cord-295807-68sukdb1	131	41	[	[	-LRB-
cord-295807-68sukdb1	131	42	59	59	CD
cord-295807-68sukdb1	131	43	]	]	-RRB-
cord-295807-68sukdb1	131	44	.	.	.
cord-295807-68sukdb1	132	1	There	there	EX
cord-295807-68sukdb1	132	2	are	be	VBP
cord-295807-68sukdb1	132	3	however	however	RB
cord-295807-68sukdb1	132	4	a	a	DT
cord-295807-68sukdb1	132	5	number	number	NN
cord-295807-68sukdb1	132	6	of	of	IN
cord-295807-68sukdb1	132	7	caveats	caveat	NNS
cord-295807-68sukdb1	132	8	associated	associate	VBN
cord-295807-68sukdb1	132	9	with	with	IN
cord-295807-68sukdb1	132	10	HCO3administration	HCO3administration	NNP
cord-295807-68sukdb1	132	11	[	[	-LRB-
cord-295807-68sukdb1	132	12	60	60	CD
cord-295807-68sukdb1	132	13	]	]	-RRB-
cord-295807-68sukdb1	132	14	.	.	.
cord-295807-68sukdb1	133	1	One	one	CD
cord-295807-68sukdb1	133	2	caveat	caveat	NN
cord-295807-68sukdb1	133	3	is	be	VBZ
cord-295807-68sukdb1	133	4	that	that	IN
cord-295807-68sukdb1	133	5	the	the	DT
cord-295807-68sukdb1	133	6	counter	counter	JJ
cord-295807-68sukdb1	133	7	anion	anion	NN
cord-295807-68sukdb1	133	8	(	(	-LRB-
cord-295807-68sukdb1	133	9	usually	usually	RB
cord-295807-68sukdb1	133	10	Na	Na	NNP
cord-295807-68sukdb1	133	11	+	+	CC
cord-295807-68sukdb1	133	12	or	or	CC
cord-295807-68sukdb1	133	13	K	K	NNP
cord-295807-68sukdb1	133	14	+	+	CC
cord-295807-68sukdb1	133	15	)	)	-RRB-
cord-295807-68sukdb1	133	16	may	may	MD
cord-295807-68sukdb1	133	17	contribute	contribute	VB
cord-295807-68sukdb1	133	18	to	to	IN
cord-295807-68sukdb1	133	19	fluid	fluid	JJ
cord-295807-68sukdb1	133	20	retention	retention	NN
cord-295807-68sukdb1	133	21	or	or	CC
cord-295807-68sukdb1	133	22	K	k	NN
cord-295807-68sukdb1	133	23	+	+	CC
cord-295807-68sukdb1	133	24	imbalance	imbalance	NN
cord-295807-68sukdb1	133	25	.	.	.
cord-295807-68sukdb1	134	1	A	a	DT
cord-295807-68sukdb1	134	2	second	second	JJ
cord-295807-68sukdb1	134	3	caveat	caveat	NN
cord-295807-68sukdb1	134	4	is	be	VBZ
cord-295807-68sukdb1	134	5	that	that	IN
cord-295807-68sukdb1	134	6	the	the	DT
cord-295807-68sukdb1	134	7	treatment	treatment	NN
cord-295807-68sukdb1	134	8	has	have	VBZ
cord-295807-68sukdb1	134	9	the	the	DT
cord-295807-68sukdb1	134	10	potential	potential	NN
cord-295807-68sukdb1	134	11	to	to	TO
cord-295807-68sukdb1	134	12	rapidly	rapidly	RB
cord-295807-68sukdb1	134	13	generate	generate	VB
cord-295807-68sukdb1	134	14	CO2	CO2	NNP
cord-295807-68sukdb1	134	15	.	.	.
cord-295807-68sukdb1	135	1	With	with	IN
cord-295807-68sukdb1	135	2	oral	oral	JJ
cord-295807-68sukdb1	135	3	administration	administration	NN
cord-295807-68sukdb1	135	4	this	this	DT
cord-295807-68sukdb1	135	5	can	can	MD
cord-295807-68sukdb1	135	6	manifest	manifest	VB
cord-295807-68sukdb1	135	7	as	as	RB
cord-295807-68sukdb1	135	8	bloating	bloating	NN
cord-295807-68sukdb1	135	9	or	or	CC
cord-295807-68sukdb1	135	10	even	even	RB
cord-295807-68sukdb1	135	11	gastric	gastric	JJ
cord-295807-68sukdb1	135	12	rupture	rupture	NN
cord-295807-68sukdb1	135	13	,	,	,
cord-295807-68sukdb1	135	14	whereas	whereas	IN
cord-295807-68sukdb1	135	15	with	with	IN
cord-295807-68sukdb1	135	16	intravenous	intravenous	JJ
cord-295807-68sukdb1	135	17	administration	administration	NN
cord-295807-68sukdb1	135	18	,	,	,
cord-295807-68sukdb1	135	19	the	the	DT
cord-295807-68sukdb1	135	20	CO2	CO2	NNP
cord-295807-68sukdb1	135	21	,	,	,
cord-295807-68sukdb1	135	22	if	if	IN
cord-295807-68sukdb1	135	23	not	not	RB
cord-295807-68sukdb1	135	24	effectively	effectively	RB
cord-295807-68sukdb1	135	25	eliminated	eliminate	VBN
cord-295807-68sukdb1	135	26	by	by	IN
cord-295807-68sukdb1	135	27	the	the	DT
cord-295807-68sukdb1	135	28	lungs	lung	NNS
cord-295807-68sukdb1	135	29	,	,	,
cord-295807-68sukdb1	135	30	can	can	MD
cord-295807-68sukdb1	135	31	enter	enter	VB
cord-295807-68sukdb1	135	32	cells	cell	NNS
cord-295807-68sukdb1	135	33	causing	cause	VBG
cord-295807-68sukdb1	135	34	a	a	DT
cord-295807-68sukdb1	135	35	paradoxical	paradoxical	JJ
cord-295807-68sukdb1	135	36	intracellular	intracellular	JJ
cord-295807-68sukdb1	135	37	acidification	acidification	NN
cord-295807-68sukdb1	135	38	.	.	.
cord-295807-68sukdb1	136	1	A	a	DT
cord-295807-68sukdb1	136	2	third	third	JJ
cord-295807-68sukdb1	136	3	caveat	caveat	NN
cord-295807-68sukdb1	136	4	is	be	VBZ
cord-295807-68sukdb1	136	5	that	that	IN
cord-295807-68sukdb1	136	6	pH	pH	NNP
cord-295807-68sukdb1	136	7	overshoot	overshoot	VB
cord-295807-68sukdb1	136	8	(	(	-LRB-
cord-295807-68sukdb1	136	9	i.e.	i.e.	FW
cord-295807-68sukdb1	136	10	,	,	,
cord-295807-68sukdb1	136	11	overcompensation	overcompensation	NN
cord-295807-68sukdb1	136	12	that	that	WDT
cord-295807-68sukdb1	136	13	creates	create	VBZ
cord-295807-68sukdb1	136	14	its	-PRON-	PRP$
cord-295807-68sukdb1	136	15	own	own	JJ
cord-295807-68sukdb1	136	16	pH	ph	NN
cord-295807-68sukdb1	136	17	disturbance	disturbance	NN
cord-295807-68sukdb1	136	18	)	)	-RRB-
cord-295807-68sukdb1	136	19	is	be	VBZ
cord-295807-68sukdb1	136	20	possible	possible	JJ
cord-295807-68sukdb1	136	21	if	if	IN
cord-295807-68sukdb1	136	22	the	the	DT
cord-295807-68sukdb1	136	23	dose	dose	NN
cord-295807-68sukdb1	136	24	is	be	VBZ
cord-295807-68sukdb1	136	25	not	not	RB
cord-295807-68sukdb1	136	26	well	well	RB
cord-295807-68sukdb1	136	27	titrated	titrate	VBN
cord-295807-68sukdb1	136	28	.	.	.
cord-295807-68sukdb1	137	1	However	however	RB
cord-295807-68sukdb1	137	2	,	,	,
cord-295807-68sukdb1	137	3	in	in	IN
cord-295807-68sukdb1	137	4	practice	practice	NN
cord-295807-68sukdb1	137	5	,	,	,
cord-295807-68sukdb1	137	6	manifestation	manifestation	NN
cord-295807-68sukdb1	137	7	of	of	IN
cord-295807-68sukdb1	137	8	the	the	DT
cord-295807-68sukdb1	137	9	side	side	NN
cord-295807-68sukdb1	137	10	effects	effect	NNS
cord-295807-68sukdb1	137	11	associated	associate	VBN
cord-295807-68sukdb1	137	12	with	with	IN
cord-295807-68sukdb1	137	13	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	137	14	administration	administration	NN
cord-295807-68sukdb1	137	15	is	be	VBZ
cord-295807-68sukdb1	137	16	not	not	RB
cord-295807-68sukdb1	137	17	a	a	DT
cord-295807-68sukdb1	137	18	foregone	foregone	JJ
cord-295807-68sukdb1	137	19	conclusion	conclusion	NN
cord-295807-68sukdb1	137	20	[	[	-LRB-
cord-295807-68sukdb1	137	21	61	61	CD
cord-295807-68sukdb1	137	22	,	,	,
cord-295807-68sukdb1	137	23	62	62	CD
cord-295807-68sukdb1	137	24	]	]	-RRB-
cord-295807-68sukdb1	137	25	.	.	.
cord-295807-68sukdb1	138	1	Alternative	alternative	JJ
cord-295807-68sukdb1	138	2	vehicles	vehicle	NNS
cord-295807-68sukdb1	138	3	for	for	IN
cord-295807-68sukdb1	138	4	intravenous	intravenous	JJ
cord-295807-68sukdb1	138	5	alkali	alkali	NN
cord-295807-68sukdb1	138	6	delivery	delivery	NN
cord-295807-68sukdb1	138	7	such	such	JJ
cord-295807-68sukdb1	138	8	as	as	IN
cord-295807-68sukdb1	138	9	Na2CO3	Na2CO3	NNP
cord-295807-68sukdb1	138	10	and	and	CC
cord-295807-68sukdb1	138	11	CaCO3	CaCO3	NNP
cord-295807-68sukdb1	138	12	produce	produce	VBP
cord-295807-68sukdb1	138	13	less	less	JJR
cord-295807-68sukdb1	138	14	CO2	co2	NN
cord-295807-68sukdb1	138	15	per	per	IN
cord-295807-68sukdb1	138	16	neutralized	neutralize	VBN
cord-295807-68sukdb1	138	17	H	h	NN
cord-295807-68sukdb1	138	18	+	+	CC
cord-295807-68sukdb1	138	19	and	and	CC
cord-295807-68sukdb1	138	20	impose	impose	VB
cord-295807-68sukdb1	138	21	less	less	JJR
cord-295807-68sukdb1	138	22	of	of	IN
cord-295807-68sukdb1	138	23	an	an	DT
cord-295807-68sukdb1	138	24	osmotic	osmotic	JJ
cord-295807-68sukdb1	138	25	stress	stress	NN
cord-295807-68sukdb1	138	26	[	[	-LRB-
cord-295807-68sukdb1	138	27	63	63	CD
cord-295807-68sukdb1	138	28	]	]	-RRB-
cord-295807-68sukdb1	138	29	.	.	.
cord-295807-68sukdb1	139	1	Carbicarb	Carbicarb	NNP
cord-295807-68sukdb1	139	2	is	be	VBZ
cord-295807-68sukdb1	139	3	a	a	DT
cord-295807-68sukdb1	139	4	mixture	mixture	NN
cord-295807-68sukdb1	139	5	of	of	IN
cord-295807-68sukdb1	139	6	NaHCO3	nahco3	NN
cord-295807-68sukdb1	139	7	and	and	CC
cord-295807-68sukdb1	139	8	Na2CO3	Na2CO3	NNP
cord-295807-68sukdb1	139	9	that	that	WDT
cord-295807-68sukdb1	139	10	does	do	VBZ
cord-295807-68sukdb1	139	11	not	not	RB
cord-295807-68sukdb1	139	12	cause	cause	VB
cord-295807-68sukdb1	139	13	intracellular	intracellular	JJ
cord-295807-68sukdb1	139	14	acidification	acidification	NN
cord-295807-68sukdb1	139	15	[	[	-LRB-
cord-295807-68sukdb1	139	16	64	64	CD
cord-295807-68sukdb1	139	17	,	,	,
cord-295807-68sukdb1	139	18	65	65	CD
cord-295807-68sukdb1	139	19	]	]	-RRB-
cord-295807-68sukdb1	139	20	.	.	.
cord-295807-68sukdb1	140	1	Citrate	Citrate	NNP
cord-295807-68sukdb1	140	2	salts	salt	NNS
cord-295807-68sukdb1	140	3	provide	provide	VBP
cord-295807-68sukdb1	140	4	a	a	DT
cord-295807-68sukdb1	140	5	gentler	gentle	JJR
cord-295807-68sukdb1	140	6	,	,	,
cord-295807-68sukdb1	140	7	indirect	indirect	JJ
cord-295807-68sukdb1	140	8	mean	mean	NN
cord-295807-68sukdb1	140	9	of	of	IN
cord-295807-68sukdb1	140	10	raising	raise	VBG
cord-295807-68sukdb1	140	11	HCO3as	HCO3as	NNP
cord-295807-68sukdb1	140	12	citrate	citrate	NN
cord-295807-68sukdb1	140	13	is	be	VBZ
cord-295807-68sukdb1	140	14	converted	convert	VBN
cord-295807-68sukdb1	140	15	into	into	IN
cord-295807-68sukdb1	140	16	HCO3	HCO3	NNP
cord-295807-68sukdb1	140	17	in	in	IN
cord-295807-68sukdb1	140	18	the	the	DT
cord-295807-68sukdb1	140	19	liver	liver	NN
cord-295807-68sukdb1	140	20	.	.	.
cord-295807-68sukdb1	141	1	Alternative	alternative	JJ
cord-295807-68sukdb1	141	2	buffers	buffer	NNS
cord-295807-68sukdb1	141	3	such	such	JJ
cord-295807-68sukdb1	141	4	as	as	IN
cord-295807-68sukdb1	141	5	THAM	THAM	NNP
cord-295807-68sukdb1	141	6	(	(	-LRB-
cord-295807-68sukdb1	141	7	tris	tris	NNP
cord-295807-68sukdb1	141	8	-	-	HYPH
cord-295807-68sukdb1	141	9	hydroxymethyl	hydroxymethyl	NNP
cord-295807-68sukdb1	141	10	aminomethane	aminomethane	NNP
cord-295807-68sukdb1	142	1	aka	aka	RB
cord-295807-68sukdb1	142	2	Tris	Tris	NNP
cord-295807-68sukdb1	142	3	-	-	HYPH
cord-295807-68sukdb1	142	4	base	base	NN
cord-295807-68sukdb1	143	1	aka	aka	RB
cord-295807-68sukdb1	143	2	tromethamine	tromethamine	NNP
cord-295807-68sukdb1	143	3	aka	aka	RB
cord-295807-68sukdb1	143	4	trometamol	trometamol	NNP
cord-295807-68sukdb1	143	5	)	)	-RRB-
cord-295807-68sukdb1	144	1	bind	bind	VB
cord-295807-68sukdb1	144	2	H	H	NNP
cord-295807-68sukdb1	144	3	+	+	CC
cord-295807-68sukdb1	144	4	without	without	IN
cord-295807-68sukdb1	144	5	generating	generate	VBG
cord-295807-68sukdb1	144	6	CO2	co2	NN
cord-295807-68sukdb1	144	7	and	and	CC
cord-295807-68sukdb1	144	8	the	the	DT
cord-295807-68sukdb1	144	9	protonated	protonated	JJ
cord-295807-68sukdb1	144	10	product	product	NN
cord-295807-68sukdb1	144	11	is	be	VBZ
cord-295807-68sukdb1	144	12	readily	readily	RB
cord-295807-68sukdb1	144	13	cleared	clear	VBN
cord-295807-68sukdb1	144	14	by	by	IN
cord-295807-68sukdb1	144	15	the	the	DT
cord-295807-68sukdb1	144	16	kidneys	kidney	NNS
cord-295807-68sukdb1	144	17	[	[	-LRB-
cord-295807-68sukdb1	144	18	66	66	CD
cord-295807-68sukdb1	144	19	]	]	-RRB-
cord-295807-68sukdb1	144	20	.	.	.
cord-295807-68sukdb1	145	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	145	2	,	,	,
cord-295807-68sukdb1	145	3	because	because	IN
cord-295807-68sukdb1	145	4	a	a	DT
cord-295807-68sukdb1	145	5	certain	certain	JJ
cord-295807-68sukdb1	145	6	proportion	proportion	NN
cord-295807-68sukdb1	145	7	of	of	IN
cord-295807-68sukdb1	145	8	THAM	THAM	NNP
cord-295807-68sukdb1	145	9	is	be	VBZ
cord-295807-68sukdb1	145	10	uncharged	uncharged	JJ
cord-295807-68sukdb1	145	11	at	at	IN
cord-295807-68sukdb1	145	12	physiological	physiological	JJ
cord-295807-68sukdb1	145	13	pH	ph	NN
cord-295807-68sukdb1	145	14	,	,	,
cord-295807-68sukdb1	145	15	it	-PRON-	PRP
cord-295807-68sukdb1	145	16	is	be	VBZ
cord-295807-68sukdb1	145	17	cell	cell	NN
cord-295807-68sukdb1	145	18	permeable	permeable	JJ
cord-295807-68sukdb1	145	19	and	and	CC
cord-295807-68sukdb1	145	20	can	can	MD
cord-295807-68sukdb1	145	21	counter	counter	VB
cord-295807-68sukdb1	145	22	intracellular	intracellular	JJ
cord-295807-68sukdb1	145	23	acidosis	acidosis	NN
cord-295807-68sukdb1	145	24	.	.	.
cord-295807-68sukdb1	146	1	Other	other	JJ
cord-295807-68sukdb1	146	2	HCO3	HCO3	NNP
cord-295807-68sukdb1	146	3	--replacing	--replacing	NN
cord-295807-68sukdb1	146	4	bases	basis	NNS
cord-295807-68sukdb1	146	5	include	include	VBP
cord-295807-68sukdb1	146	6	lactate	lactate	NN
cord-295807-68sukdb1	146	7	and	and	CC
cord-295807-68sukdb1	146	8	acetate	acetate	NN
cord-295807-68sukdb1	146	9	[	[	-LRB-
cord-295807-68sukdb1	146	10	67	67	CD
cord-295807-68sukdb1	146	11	,	,	,
cord-295807-68sukdb1	146	12	68	68	CD
cord-295807-68sukdb1	146	13	]	]	-RRB-
cord-295807-68sukdb1	146	14	.	.	.
cord-295807-68sukdb1	147	1	Finally	finally	RB
cord-295807-68sukdb1	147	2	,	,	,
cord-295807-68sukdb1	147	3	potential	potential	JJ
cord-295807-68sukdb1	147	4	side	side	NN
cord-295807-68sukdb1	147	5	effects	effect	NNS
cord-295807-68sukdb1	147	6	can	can	MD
cord-295807-68sukdb1	147	7	be	be	VB
cord-295807-68sukdb1	147	8	ameliorated	ameliorate	VBN
cord-295807-68sukdb1	147	9	by	by	IN
cord-295807-68sukdb1	147	10	administering	administer	VBG
cord-295807-68sukdb1	147	11	buffers	buffer	NNS
cord-295807-68sukdb1	147	12	at	at	IN
cord-295807-68sukdb1	147	13	a	a	DT
cord-295807-68sukdb1	147	14	lower	low	JJR
cord-295807-68sukdb1	147	15	dose	dose	NN
cord-295807-68sukdb1	147	16	as	as	IN
cord-295807-68sukdb1	147	17	part	part	NN
cord-295807-68sukdb1	147	18	of	of	IN
cord-295807-68sukdb1	147	19	an	an	DT
cord-295807-68sukdb1	147	20	intravenous	intravenous	JJ
cord-295807-68sukdb1	147	21	cocktail	cocktail	NN
cord-295807-68sukdb1	147	22	of	of	IN
cord-295807-68sukdb1	147	23	buffers	buffer	NNS
cord-295807-68sukdb1	147	24	.	.	.
cord-295807-68sukdb1	148	1	For	for	IN
cord-295807-68sukdb1	148	2	example	example	NN
cord-295807-68sukdb1	148	3	,	,	,
cord-295807-68sukdb1	148	4	Tribonat	Tribonat	NNP
cord-295807-68sukdb1	148	5	is	be	VBZ
cord-295807-68sukdb1	148	6	a	a	DT
cord-295807-68sukdb1	148	7	mixture	mixture	NN
cord-295807-68sukdb1	148	8	that	that	WDT
cord-295807-68sukdb1	148	9	includes	include	VBZ
cord-295807-68sukdb1	148	10	NaHCO3	nahco3	NN
cord-295807-68sukdb1	148	11	,	,	,
cord-295807-68sukdb1	148	12	Na2HPO4	Na2HPO4	NNP
cord-295807-68sukdb1	148	13	,	,	,
cord-295807-68sukdb1	148	14	and	and	CC
cord-295807-68sukdb1	148	15	sodium	sodium	NN
cord-295807-68sukdb1	148	16	acetate	acetate	NN
cord-295807-68sukdb1	148	17	[	[	-LRB-
cord-295807-68sukdb1	148	18	60	60	CD
cord-295807-68sukdb1	148	19	,	,	,
cord-295807-68sukdb1	148	20	67	67	CD
cord-295807-68sukdb1	148	21	]	]	-RRB-
cord-295807-68sukdb1	148	22	.	.	.
cord-295807-68sukdb1	149	1	An	an	DT
cord-295807-68sukdb1	149	2	added	add	VBN
cord-295807-68sukdb1	149	3	bonus	bonus	NN
cord-295807-68sukdb1	149	4	of	of	IN
cord-295807-68sukdb1	149	5	that	that	DT
cord-295807-68sukdb1	149	6	mixture	mixture	NN
cord-295807-68sukdb1	149	7	is	be	VBZ
cord-295807-68sukdb1	149	8	that	that	IN
cord-295807-68sukdb1	149	9	the	the	DT
cord-295807-68sukdb1	149	10	inclusion	inclusion	NN
cord-295807-68sukdb1	149	11	of	of	IN
cord-295807-68sukdb1	149	12	phosphate	phosphate	NN
cord-295807-68sukdb1	149	13	counters	counter	NNS
cord-295807-68sukdb1	149	14	the	the	DT
cord-295807-68sukdb1	149	15	hypophosphatemia	hypophosphatemia	NN
cord-295807-68sukdb1	149	16	associated	associate	VBN
cord-295807-68sukdb1	149	17	with	with	IN
cord-295807-68sukdb1	149	18	MAc	MAc	NNP
cord-295807-68sukdb1	149	19	.	.	.
cord-295807-68sukdb1	150	1	Dietary	dietary	JJ
cord-295807-68sukdb1	150	2	acid	acid	NN
cord-295807-68sukdb1	150	3	load	load	NN
cord-295807-68sukdb1	150	4	is	be	VBZ
cord-295807-68sukdb1	150	5	associated	associate	VBN
cord-295807-68sukdb1	150	6	with	with	IN
cord-295807-68sukdb1	150	7	lower	low	JJR
cord-295807-68sukdb1	150	8	serum	serum	NN
cord-295807-68sukdb1	150	9	HCO3	HCO3	NNP
cord-295807-68sukdb1	150	10	-	-	HYPH
cord-295807-68sukdb1	150	11	[	[	-LRB-
cord-295807-68sukdb1	150	12	2	2	CD
cord-295807-68sukdb1	150	13	,	,	,
cord-295807-68sukdb1	150	14	69	69	CD
cord-295807-68sukdb1	150	15	,	,	,
cord-295807-68sukdb1	150	16	70	70	CD
cord-295807-68sukdb1	150	17	]	]	-RRB-
cord-295807-68sukdb1	150	18	and	and	CC
cord-295807-68sukdb1	150	19	thus	thus	RB
cord-295807-68sukdb1	150	20	there	there	EX
cord-295807-68sukdb1	150	21	is	be	VBZ
cord-295807-68sukdb1	150	22	scope	scope	NN
cord-295807-68sukdb1	150	23	for	for	IN
cord-295807-68sukdb1	150	24	dietary	dietary	JJ
cord-295807-68sukdb1	150	25	correction	correction	NN
cord-295807-68sukdb1	150	26	of	of	IN
cord-295807-68sukdb1	150	27	MAc	MAc	NNP
cord-295807-68sukdb1	150	28	by	by	IN
cord-295807-68sukdb1	150	29	,	,	,
cord-295807-68sukdb1	150	30	for	for	IN
cord-295807-68sukdb1	150	31	example	example	NN
cord-295807-68sukdb1	150	32	,	,	,
cord-295807-68sukdb1	150	33	adherence	adherence	NN
cord-295807-68sukdb1	150	34	to	to	IN
cord-295807-68sukdb1	150	35	a	a	DT
cord-295807-68sukdb1	150	36	very	very	RB
cord-295807-68sukdb1	150	37	low	low	JJ
cord-295807-68sukdb1	150	38	protein	protein	NN
cord-295807-68sukdb1	150	39	[	[	-LRB-
cord-295807-68sukdb1	150	40	71	71	CD
cord-295807-68sukdb1	150	41	]	]	-RRB-
cord-295807-68sukdb1	150	42	or	or	CC
cord-295807-68sukdb1	150	43	otherwise	otherwise	RB
cord-295807-68sukdb1	150	44	"	"	``
cord-295807-68sukdb1	150	45	alkaline	alkaline	JJ
cord-295807-68sukdb1	150	46	"	"	''
cord-295807-68sukdb1	150	47	diet	diet	NN
cord-295807-68sukdb1	150	48	[	[	-LRB-
cord-295807-68sukdb1	150	49	72	72	CD
cord-295807-68sukdb1	150	50	]	]	-RRB-
cord-295807-68sukdb1	150	51	.	.	.
cord-295807-68sukdb1	151	1	pH	pH	NNP
cord-295807-68sukdb1	151	2	imbalance	imbalance	NN
cord-295807-68sukdb1	151	3	in	in	IN
cord-295807-68sukdb1	151	4	MAc	MAc	NNP
cord-295807-68sukdb1	151	5	can	can	MD
cord-295807-68sukdb1	151	6	also	also	RB
cord-295807-68sukdb1	151	7	be	be	VB
cord-295807-68sukdb1	151	8	redressed	redress	VBN
cord-295807-68sukdb1	151	9	by	by	IN
cord-295807-68sukdb1	151	10	increasing	increase	VBG
cord-295807-68sukdb1	151	11	H	h	NN
cord-295807-68sukdb1	151	12	+	+	CC
cord-295807-68sukdb1	151	13	excretion	excretion	NN
cord-295807-68sukdb1	151	14	.	.	.
cord-295807-68sukdb1	152	1	The	the	DT
cord-295807-68sukdb1	152	2	thiazide	thiazide	NN
cord-295807-68sukdb1	152	3	diuretic	diuretic	JJ
cord-295807-68sukdb1	152	4	hydrochlorothiazide	hydrochlorothiazide	NN
cord-295807-68sukdb1	152	5	increases	increase	VBZ
cord-295807-68sukdb1	152	6	H	h	NN
cord-295807-68sukdb1	152	7	+	+	CC
cord-295807-68sukdb1	152	8	secretion	secretion	NN
cord-295807-68sukdb1	152	9	by	by	IN
cord-295807-68sukdb1	152	10	the	the	DT
cord-295807-68sukdb1	152	11	renal	renal	JJ
cord-295807-68sukdb1	152	12	collecting	collecting	NN
cord-295807-68sukdb1	152	13	duct	duct	NN
cord-295807-68sukdb1	152	14	and	and	CC
cord-295807-68sukdb1	152	15	has	have	VBZ
cord-295807-68sukdb1	152	16	been	be	VBN
cord-295807-68sukdb1	152	17	used	use	VBN
cord-295807-68sukdb1	152	18	as	as	IN
cord-295807-68sukdb1	152	19	an	an	DT
cord-295807-68sukdb1	152	20	adjunct	adjunct	JJ
cord-295807-68sukdb1	152	21	therapy	therapy	NN
cord-295807-68sukdb1	152	22	with	with	IN
cord-295807-68sukdb1	152	23	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	152	24	for	for	IN
cord-295807-68sukdb1	152	25	MAc	MAc	NNP
cord-295807-68sukdb1	152	26	[	[	-LRB-
cord-295807-68sukdb1	152	27	73	73	CD
cord-295807-68sukdb1	152	28	]	]	-RRB-
cord-295807-68sukdb1	152	29	.	.	.
cord-295807-68sukdb1	153	1	Its	-PRON-	PRP$
cord-295807-68sukdb1	153	2	role	role	NN
cord-295807-68sukdb1	153	3	as	as	IN
cord-295807-68sukdb1	153	4	a	a	DT
cord-295807-68sukdb1	153	5	diuretic	diuretic	NN
cord-295807-68sukdb1	153	6	ought	ought	MD
cord-295807-68sukdb1	153	7	also	also	RB
cord-295807-68sukdb1	153	8	to	to	TO
cord-295807-68sukdb1	153	9	assist	assist	VB
cord-295807-68sukdb1	153	10	with	with	IN
cord-295807-68sukdb1	153	11	excretion	excretion	NN
cord-295807-68sukdb1	153	12	of	of	IN
cord-295807-68sukdb1	153	13	the	the	DT
cord-295807-68sukdb1	153	14	Na	Na	NNP
cord-295807-68sukdb1	153	15	+	+	CC
cord-295807-68sukdb1	153	16	load	load	NN
cord-295807-68sukdb1	153	17	associated	associate	VBN
cord-295807-68sukdb1	153	18	with	with	IN
cord-295807-68sukdb1	153	19	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	153	20	treatment	treatment	NN
cord-295807-68sukdb1	153	21	.	.	.
cord-295807-68sukdb1	154	1	Veverimer	Veverimer	NNP
cord-295807-68sukdb1	154	2	is	be	VBZ
cord-295807-68sukdb1	154	3	an	an	DT
cord-295807-68sukdb1	154	4	orally	orally	RB
cord-295807-68sukdb1	154	5	dosed	dose	VBN
cord-295807-68sukdb1	154	6	H	h	NN
cord-295807-68sukdb1	154	7	+	+	CC
cord-295807-68sukdb1	154	8	binding	bind	VBG
cord-295807-68sukdb1	154	9	polymer	polymer	NN
cord-295807-68sukdb1	154	10	that	that	WDT
cord-295807-68sukdb1	154	11	is	be	VBZ
cord-295807-68sukdb1	154	12	in	in	IN
cord-295807-68sukdb1	154	13	Phase	Phase	NNP
cord-295807-68sukdb1	154	14	III	iii	CD
cord-295807-68sukdb1	154	15	clinical	clinical	JJ
cord-295807-68sukdb1	154	16	trials	trial	NNS
cord-295807-68sukdb1	154	17	at	at	IN
cord-295807-68sukdb1	154	18	the	the	DT
cord-295807-68sukdb1	154	19	time	time	NN
cord-295807-68sukdb1	154	20	of	of	IN
cord-295807-68sukdb1	154	21	writing	writing	NN
cord-295807-68sukdb1	154	22	for	for	IN
cord-295807-68sukdb1	154	23	the	the	DT
cord-295807-68sukdb1	154	24	treatment	treatment	NN
cord-295807-68sukdb1	154	25	of	of	IN
cord-295807-68sukdb1	154	26	MAc	MAc	NNP
cord-295807-68sukdb1	154	27	in	in	IN
cord-295807-68sukdb1	154	28	the	the	DT
cord-295807-68sukdb1	154	29	context	context	NN
cord-295807-68sukdb1	154	30	of	of	IN
cord-295807-68sukdb1	154	31	chronic	chronic	JJ
cord-295807-68sukdb1	154	32	kidney	kidney	NN
cord-295807-68sukdb1	154	33	disease	disease	NN
cord-295807-68sukdb1	154	34	(	(	-LRB-
cord-295807-68sukdb1	154	35	ClinicalTrials.gov	ClinicalTrials.gov	NNP
cord-295807-68sukdb1	154	36	Identifier	Identifier	NNP
cord-295807-68sukdb1	154	37	:	:	:
cord-295807-68sukdb1	154	38	NCT03710291	NCT03710291	NNP
cord-295807-68sukdb1	154	39	)	)	-RRB-
cord-295807-68sukdb1	154	40	.	.	.
cord-295807-68sukdb1	155	1	It	-PRON-	PRP
cord-295807-68sukdb1	155	2	binds	bind	VBZ
cord-295807-68sukdb1	155	3	H	h	NN
cord-295807-68sukdb1	155	4	+	+	CC
cord-295807-68sukdb1	155	5	in	in	IN
cord-295807-68sukdb1	155	6	the	the	DT
cord-295807-68sukdb1	155	7	stomach	stomach	NN
cord-295807-68sukdb1	155	8	for	for	IN
cord-295807-68sukdb1	155	9	eventual	eventual	JJ
cord-295807-68sukdb1	155	10	excretion	excretion	NN
cord-295807-68sukdb1	155	11	in	in	IN
cord-295807-68sukdb1	155	12	the	the	DT
cord-295807-68sukdb1	155	13	feces	fece	NNS
cord-295807-68sukdb1	155	14	[	[	-LRB-
cord-295807-68sukdb1	155	15	59	59	CD
cord-295807-68sukdb1	155	16	,	,	,
cord-295807-68sukdb1	155	17	74	74	CD
cord-295807-68sukdb1	155	18	,	,	,
cord-295807-68sukdb1	155	19	75	75	CD
cord-295807-68sukdb1	155	20	]	]	-RRB-
cord-295807-68sukdb1	155	21	.	.	.
cord-295807-68sukdb1	156	1	Moreover	moreover	RB
cord-295807-68sukdb1	156	2	,	,	,
cord-295807-68sukdb1	156	3	the	the	DT
cord-295807-68sukdb1	156	4	raising	raising	NN
cord-295807-68sukdb1	156	5	of	of	IN
cord-295807-68sukdb1	156	6	gastric	gastric	JJ
cord-295807-68sukdb1	156	7	pH	ph	NN
cord-295807-68sukdb1	156	8	by	by	IN
cord-295807-68sukdb1	156	9	veverimer	veverimer	NNP
cord-295807-68sukdb1	156	10	prompts	prompt	VBZ
cord-295807-68sukdb1	156	11	parietal	parietal	JJ
cord-295807-68sukdb1	156	12	cells	cell	NNS
cord-295807-68sukdb1	156	13	to	to	TO
cord-295807-68sukdb1	156	14	deposit	deposit	VB
cord-295807-68sukdb1	156	15	HCO3into	HCO3into	NNP
cord-295807-68sukdb1	156	16	circulation	circulation	NN
cord-295807-68sukdb1	156	17	,	,	,
cord-295807-68sukdb1	156	18	mimicking	mimic	VBG
cord-295807-68sukdb1	156	19	the	the	DT
cord-295807-68sukdb1	156	20	alkaline	alkaline	JJ
cord-295807-68sukdb1	156	21	tide	tide	NN
cord-295807-68sukdb1	156	22	associated	associate	VBN
cord-295807-68sukdb1	156	23	with	with	IN
cord-295807-68sukdb1	156	24	feeding	feeding	NN
cord-295807-68sukdb1	156	25	.	.	.
cord-295807-68sukdb1	157	1	Another	another	DT
cord-295807-68sukdb1	157	2	approach	approach	NN
cord-295807-68sukdb1	157	3	to	to	TO
cord-295807-68sukdb1	157	4	counter	counter	VB
cord-295807-68sukdb1	157	5	MAc	MAc	NNP
cord-295807-68sukdb1	157	6	,	,	,
cord-295807-68sukdb1	157	7	is	be	VBZ
cord-295807-68sukdb1	157	8	to	to	TO
cord-295807-68sukdb1	157	9	increase	increase	VB
cord-295807-68sukdb1	157	10	cellular	cellular	JJ
cord-295807-68sukdb1	157	11	H	h	NN
cord-295807-68sukdb1	157	12	+	+	CC
cord-295807-68sukdb1	157	13	consumption	consumption	NN
cord-295807-68sukdb1	157	14	(	(	-LRB-
cord-295807-68sukdb1	157	15	and/or	and/or	CC
cord-295807-68sukdb1	157	16	decrease	decrease	VB
cord-295807-68sukdb1	157	17	lactic	lactic	JJ
cord-295807-68sukdb1	157	18	acid	acid	NN
cord-295807-68sukdb1	157	19	production	production	NN
cord-295807-68sukdb1	157	20	)	)	-RRB-
cord-295807-68sukdb1	157	21	by	by	IN
cord-295807-68sukdb1	157	22	metabolic	metabolic	JJ
cord-295807-68sukdb1	157	23	means	mean	NNS
cord-295807-68sukdb1	157	24	either	either	CC
cord-295807-68sukdb1	157	25	by	by	IN
cord-295807-68sukdb1	157	26	pyruvate	pyruvate	NNP
cord-295807-68sukdb1	157	27	administration	administration	NN
cord-295807-68sukdb1	157	28	or	or	CC
cord-295807-68sukdb1	157	29	by	by	IN
cord-295807-68sukdb1	157	30	stimulating	stimulate	VBG
cord-295807-68sukdb1	157	31	pyruvate	pyruvate	NN
cord-295807-68sukdb1	157	32	dehydrogenase	dehydrogenase	NN
cord-295807-68sukdb1	157	33	using	use	VBG
cord-295807-68sukdb1	157	34	dichloroacetate	dichloroacetate	NNP
cord-295807-68sukdb1	157	35	(	(	-LRB-
cord-295807-68sukdb1	157	36	DCA	DCA	NNP
cord-295807-68sukdb1	157	37	)	)	-RRB-
cord-295807-68sukdb1	157	38	[	[	-LRB-
cord-295807-68sukdb1	157	39	76	76	CD
cord-295807-68sukdb1	157	40	,	,	,
cord-295807-68sukdb1	157	41	77	77	CD
cord-295807-68sukdb1	157	42	]	]	-RRB-
cord-295807-68sukdb1	157	43	.	.	.
cord-295807-68sukdb1	158	1	MAlk	MAlk	NNS
cord-295807-68sukdb1	158	2	is	be	VBZ
cord-295807-68sukdb1	158	3	defined	define	VBN
cord-295807-68sukdb1	158	4	as	as	IN
cord-295807-68sukdb1	158	5	alkalemia	alkalemia	NN
cord-295807-68sukdb1	158	6	caused	cause	VBN
cord-295807-68sukdb1	158	7	by	by	IN
cord-295807-68sukdb1	158	8	a	a	DT
cord-295807-68sukdb1	158	9	primary	primary	JJ
cord-295807-68sukdb1	158	10	excess	excess	NN
cord-295807-68sukdb1	158	11	of	of	IN
cord-295807-68sukdb1	158	12	HCO3	HCO3	NNP
cord-295807-68sukdb1	158	13	-	-	HYPH
cord-295807-68sukdb1	158	14	.	.	.
cord-295807-68sukdb1	159	1	MAlk	MAlk	NNS
cord-295807-68sukdb1	159	2	may	may	MD
cord-295807-68sukdb1	159	3	follow	follow	VB
cord-295807-68sukdb1	159	4	volume	volume	NN
cord-295807-68sukdb1	159	5	depletion	depletion	NN
cord-295807-68sukdb1	159	6	or	or	CC
cord-295807-68sukdb1	159	7	hyperaldosteronism	hyperaldosteronism	NN
cord-295807-68sukdb1	159	8	(	(	-LRB-
cord-295807-68sukdb1	159	9	promotes	promote	VBZ
cord-295807-68sukdb1	159	10	renal	renal	JJ
cord-295807-68sukdb1	159	11	H	h	NN
cord-295807-68sukdb1	159	12	+	+	CC
cord-295807-68sukdb1	159	13	secretion	secretion	NN
cord-295807-68sukdb1	159	14	)	)	-RRB-
cord-295807-68sukdb1	159	15	,	,	,
cord-295807-68sukdb1	159	16	vomiting	vomit	VBG
cord-295807-68sukdb1	159	17	(	(	-LRB-
cord-295807-68sukdb1	159	18	eliminate	eliminate	VB
cord-295807-68sukdb1	159	19	gastric	gastric	JJ
cord-295807-68sukdb1	159	20	acid	acid	NN
cord-295807-68sukdb1	159	21	,	,	,
cord-295807-68sukdb1	159	22	stimulating	stimulate	VBG
cord-295807-68sukdb1	159	23	an	an	DT
cord-295807-68sukdb1	159	24	alkaline	alkaline	JJ
cord-295807-68sukdb1	159	25	tide	tide	NN
cord-295807-68sukdb1	159	26	)	)	-RRB-
cord-295807-68sukdb1	159	27	,	,	,
cord-295807-68sukdb1	159	28	or	or	CC
cord-295807-68sukdb1	159	29	the	the	DT
cord-295807-68sukdb1	159	30	use	use	NN
cord-295807-68sukdb1	159	31	of	of	IN
cord-295807-68sukdb1	159	32	certain	certain	JJ
cord-295807-68sukdb1	159	33	pharmaceuticals	pharmaceutical	NNS
cord-295807-68sukdb1	159	34	that	that	WDT
cord-295807-68sukdb1	159	35	mimic	mimic	VBP
cord-295807-68sukdb1	159	36	those	those	DT
cord-295807-68sukdb1	159	37	responses	response	NNS
cord-295807-68sukdb1	159	38	(	(	-LRB-
cord-295807-68sukdb1	159	39	loop	loop	NN
cord-295807-68sukdb1	159	40	diuretics	diuretic	NNS
cord-295807-68sukdb1	159	41	,	,	,
cord-295807-68sukdb1	159	42	antacids	antacid	NNS
cord-295807-68sukdb1	159	43	)	)	-RRB-
cord-295807-68sukdb1	159	44	.	.	.
cord-295807-68sukdb1	160	1	Clinical	clinical	JJ
cord-295807-68sukdb1	160	2	manifestations	manifestation	NNS
cord-295807-68sukdb1	160	3	can	can	MD
cord-295807-68sukdb1	160	4	include	include	VB
cord-295807-68sukdb1	160	5	confusion	confusion	NN
cord-295807-68sukdb1	160	6	and	and	CC
cord-295807-68sukdb1	160	7	tetany	tetany	NN
cord-295807-68sukdb1	160	8	[	[	-LRB-
cord-295807-68sukdb1	160	9	58	58	CD
cord-295807-68sukdb1	160	10	]	]	-RRB-
cord-295807-68sukdb1	160	11	.	.	.
cord-295807-68sukdb1	161	1	MAlk	MAlk	NNS
cord-295807-68sukdb1	161	2	can	can	MD
cord-295807-68sukdb1	161	3	also	also	RB
cord-295807-68sukdb1	161	4	have	have	VB
cord-295807-68sukdb1	161	5	a	a	DT
cord-295807-68sukdb1	161	6	genetic	genetic	JJ
cord-295807-68sukdb1	161	7	cause	cause	NN
cord-295807-68sukdb1	161	8	.	.	.
cord-295807-68sukdb1	162	1	For	for	IN
cord-295807-68sukdb1	162	2	example	example	NN
cord-295807-68sukdb1	162	3	,	,	,
cord-295807-68sukdb1	162	4	Liddle	Liddle	NNP
cord-295807-68sukdb1	162	5	Syndrome	Syndrome	NNP
cord-295807-68sukdb1	162	6	is	be	VBZ
cord-295807-68sukdb1	162	7	associated	associate	VBN
cord-295807-68sukdb1	162	8	with	with	IN
cord-295807-68sukdb1	162	9	hyperactivity	hyperactivity	NN
cord-295807-68sukdb1	162	10	of	of	IN
cord-295807-68sukdb1	162	11	the	the	DT
cord-295807-68sukdb1	162	12	epithelial	epithelial	JJ
cord-295807-68sukdb1	162	13	Na	Na	NNP
cord-295807-68sukdb1	162	14	+	+	CC
cord-295807-68sukdb1	163	1	channel	channel	NNP
cord-295807-68sukdb1	163	2	ENaC	ENaC	NNP
cord-295807-68sukdb1	163	3	,	,	,
cord-295807-68sukdb1	164	1	the	the	DT
cord-295807-68sukdb1	164	2	action	action	NN
cord-295807-68sukdb1	164	3	of	of	IN
cord-295807-68sukdb1	164	4	which	which	WDT
cord-295807-68sukdb1	164	5	promotes	promote	VBZ
cord-295807-68sukdb1	164	6	renal	renal	JJ
cord-295807-68sukdb1	164	7	H	h	NN
cord-295807-68sukdb1	164	8	+	+	CC
cord-295807-68sukdb1	164	9	secretion	secretion	NN
cord-295807-68sukdb1	164	10	[	[	-LRB-
cord-295807-68sukdb1	164	11	78	78	CD
cord-295807-68sukdb1	164	12	]	]	-RRB-
cord-295807-68sukdb1	164	13	.	.	.
cord-295807-68sukdb1	165	1	Besides	besides	IN
cord-295807-68sukdb1	165	2	treatment	treatment	NN
cord-295807-68sukdb1	165	3	of	of	IN
cord-295807-68sukdb1	165	4	the	the	DT
cord-295807-68sukdb1	165	5	underlying	underlying	JJ
cord-295807-68sukdb1	165	6	conditions	condition	NNS
cord-295807-68sukdb1	165	7	,	,	,
cord-295807-68sukdb1	165	8	correction	correction	NN
cord-295807-68sukdb1	165	9	of	of	IN
cord-295807-68sukdb1	165	10	MAlk	MAlk	NNP
cord-295807-68sukdb1	165	11	has	have	VBZ
cord-295807-68sukdb1	165	12	been	be	VBN
cord-295807-68sukdb1	165	13	achieved	achieve	VBN
cord-295807-68sukdb1	165	14	using	use	VBG
cord-295807-68sukdb1	165	15	the	the	DT
cord-295807-68sukdb1	165	16	CA	CA	NNP
cord-295807-68sukdb1	165	17	inhibitor	inhibitor	NN
cord-295807-68sukdb1	165	18	ACZ	ACZ	NNP
cord-295807-68sukdb1	165	19	,	,	,
cord-295807-68sukdb1	165	20	which	which	WDT
cord-295807-68sukdb1	165	21	by	by	IN
cord-295807-68sukdb1	165	22	itself	-PRON-	PRP
cord-295807-68sukdb1	165	23	results	result	VBZ
cord-295807-68sukdb1	165	24	in	in	IN
cord-295807-68sukdb1	165	25	MAc	MAc	NNP
cord-295807-68sukdb1	165	26	[	[	-LRB-
cord-295807-68sukdb1	165	27	79	79	CD
cord-295807-68sukdb1	165	28	]	]	-RRB-
cord-295807-68sukdb1	165	29	,	,	,
cord-295807-68sukdb1	165	30	by	by	IN
cord-295807-68sukdb1	165	31	intravenous	intravenous	JJ
cord-295807-68sukdb1	165	32	infusion	infusion	NN
cord-295807-68sukdb1	165	33	of	of	IN
cord-295807-68sukdb1	165	34	HCl	HCl	NNP
cord-295807-68sukdb1	165	35	[	[	-LRB-
cord-295807-68sukdb1	165	36	80	80	CD
cord-295807-68sukdb1	165	37	]	]	-RRB-
cord-295807-68sukdb1	165	38	,	,	,
cord-295807-68sukdb1	165	39	or	or	CC
cord-295807-68sukdb1	165	40	(	(	-LRB-
cord-295807-68sukdb1	165	41	if	if	IN
cord-295807-68sukdb1	165	42	MAlk	MAlk	NNP
cord-295807-68sukdb1	165	43	follows	follow	VBZ
cord-295807-68sukdb1	165	44	loss	loss	NN
cord-295807-68sukdb1	165	45	of	of	IN
cord-295807-68sukdb1	165	46	gastric	gastric	JJ
cord-295807-68sukdb1	165	47	acid	acid	NN
cord-295807-68sukdb1	165	48	)	)	-RRB-
cord-295807-68sukdb1	166	1	the	the	DT
cord-295807-68sukdb1	166	2	use	use	NN
cord-295807-68sukdb1	166	3	of	of	IN
cord-295807-68sukdb1	166	4	H2-receptor	H2-receptor	NNP
cord-295807-68sukdb1	166	5	agonists	agonist	NNS
cord-295807-68sukdb1	166	6	to	to	TO
cord-295807-68sukdb1	166	7	prevent	prevent	VB
cord-295807-68sukdb1	166	8	alkaline	alkaline	JJ
cord-295807-68sukdb1	166	9	tide	tide	NN
cord-295807-68sukdb1	166	10	[	[	-LRB-
cord-295807-68sukdb1	166	11	81	81	CD
cord-295807-68sukdb1	166	12	]	]	-RRB-
cord-295807-68sukdb1	167	1	(	(	-LRB-
cord-295807-68sukdb1	167	2	see	see	VB
cord-295807-68sukdb1	167	3	section	section	NN
cord-295807-68sukdb1	167	4	4.7.2	4.7.2	CD
cord-295807-68sukdb1	167	5	)	)	-RRB-
cord-295807-68sukdb1	167	6	.	.	.
cord-295807-68sukdb1	168	1	RAc	RAc	NNP
cord-295807-68sukdb1	168	2	is	be	VBZ
cord-295807-68sukdb1	168	3	defined	define	VBN
cord-295807-68sukdb1	168	4	as	as	IN
cord-295807-68sukdb1	168	5	acidemia	acidemia	NN
cord-295807-68sukdb1	168	6	with	with	IN
cord-295807-68sukdb1	168	7	a	a	DT
cord-295807-68sukdb1	168	8	plasma	plasma	NN
cord-295807-68sukdb1	168	9	pCO2	pCO2	NNP
cord-295807-68sukdb1	168	10	>	>	XX
cord-295807-68sukdb1	168	11	45	45	CD
cord-295807-68sukdb1	168	12	mmHg	mmHg	NNS
cord-295807-68sukdb1	168	13	at	at	IN
cord-295807-68sukdb1	168	14	rest	rest	NN
cord-295807-68sukdb1	168	15	and	and	CC
cord-295807-68sukdb1	168	16	at	at	IN
cord-295807-68sukdb1	168	17	sea	sea	NN
cord-295807-68sukdb1	168	18	level	level	NN
cord-295807-68sukdb1	168	19	[	[	-LRB-
cord-295807-68sukdb1	168	20	82	82	CD
cord-295807-68sukdb1	168	21	]	]	-RRB-
cord-295807-68sukdb1	168	22	.	.	.
cord-295807-68sukdb1	169	1	It	-PRON-	PRP
cord-295807-68sukdb1	169	2	usually	usually	RB
cord-295807-68sukdb1	169	3	occurs	occur	VBZ
cord-295807-68sukdb1	169	4	when	when	WRB
cord-295807-68sukdb1	169	5	there	there	EX
cord-295807-68sukdb1	169	6	is	be	VBZ
cord-295807-68sukdb1	169	7	a	a	DT
cord-295807-68sukdb1	169	8	disruption	disruption	NN
cord-295807-68sukdb1	169	9	in	in	IN
cord-295807-68sukdb1	169	10	the	the	DT
cord-295807-68sukdb1	169	11	ventilatory	ventilatory	NN
cord-295807-68sukdb1	169	12	system	system	NN
cord-295807-68sukdb1	169	13	that	that	WDT
cord-295807-68sukdb1	169	14	causes	cause	VBZ
cord-295807-68sukdb1	169	15	a	a	DT
cord-295807-68sukdb1	169	16	mismatch	mismatch	NN
cord-295807-68sukdb1	169	17	between	between	IN
cord-295807-68sukdb1	169	18	the	the	DT
cord-295807-68sukdb1	169	19	rate	rate	NN
cord-295807-68sukdb1	169	20	of	of	IN
cord-295807-68sukdb1	169	21	CO2	CO2	NNP
cord-295807-68sukdb1	169	22	removal	removal	NN
cord-295807-68sukdb1	169	23	and	and	CC
cord-295807-68sukdb1	169	24	the	the	DT
cord-295807-68sukdb1	169	25	rate	rate	NN
cord-295807-68sukdb1	169	26	of	of	IN
cord-295807-68sukdb1	169	27	CO2	CO2	NNP
cord-295807-68sukdb1	169	28	production	production	NN
cord-295807-68sukdb1	169	29	,	,	,
cord-295807-68sukdb1	169	30	with	with	IN
cord-295807-68sukdb1	169	31	consequent	consequent	JJ
cord-295807-68sukdb1	169	32	accumulation	accumulation	NN
cord-295807-68sukdb1	169	33	of	of	IN
cord-295807-68sukdb1	169	34	CO2	co2	NN
cord-295807-68sukdb1	169	35	into	into	IN
cord-295807-68sukdb1	169	36	the	the	DT
cord-295807-68sukdb1	169	37	blood	blood	NN
cord-295807-68sukdb1	169	38	(	(	-LRB-
cord-295807-68sukdb1	169	39	i.e.	i.e.	FW
cord-295807-68sukdb1	169	40	,	,	,
cord-295807-68sukdb1	169	41	CO2	CO2	NNP
cord-295807-68sukdb1	169	42	retention	retention	NN
cord-295807-68sukdb1	169	43	)	)	-RRB-
cord-295807-68sukdb1	169	44	.	.	.
cord-295807-68sukdb1	170	1	This	this	DT
cord-295807-68sukdb1	170	2	disruption	disruption	NN
cord-295807-68sukdb1	170	3	can	can	MD
cord-295807-68sukdb1	170	4	be	be	VB
cord-295807-68sukdb1	170	5	caused	cause	VBN
cord-295807-68sukdb1	170	6	by	by	IN
cord-295807-68sukdb1	170	7	(	(	-LRB-
cord-295807-68sukdb1	170	8	i	i	NN
cord-295807-68sukdb1	170	9	)	)	-RRB-
cord-295807-68sukdb1	170	10	inability	inability	NN
cord-295807-68sukdb1	170	11	of	of	IN
cord-295807-68sukdb1	170	12	the	the	DT
cord-295807-68sukdb1	170	13	lungs	lung	NNS
cord-295807-68sukdb1	170	14	to	to	TO
cord-295807-68sukdb1	170	15	remove	remove	VB
cord-295807-68sukdb1	170	16	the	the	DT
cord-295807-68sukdb1	170	17	metabolically	metabolically	RB
cord-295807-68sukdb1	170	18	produced	produce	VBN
cord-295807-68sukdb1	170	19	CO2	co2	NN
cord-295807-68sukdb1	170	20	(	(	-LRB-
cord-295807-68sukdb1	170	21	i.e.	i.e.	FW
cord-295807-68sukdb1	170	22	,	,	,
cord-295807-68sukdb1	170	23	reduced	reduce	VBN
cord-295807-68sukdb1	170	24	ventilation	ventilation	NN
cord-295807-68sukdb1	170	25	)	)	-RRB-
cord-295807-68sukdb1	170	26	,	,	,
cord-295807-68sukdb1	170	27	(	(	-LRB-
cord-295807-68sukdb1	170	28	ii	ii	NN
cord-295807-68sukdb1	170	29	)	)	-RRB-
cord-295807-68sukdb1	170	30	defects	defect	NNS
cord-295807-68sukdb1	170	31	in	in	IN
cord-295807-68sukdb1	170	32	CO2	CO2	NNP
cord-295807-68sukdb1	170	33	transport	transport	NN
cord-295807-68sukdb1	170	34	from	from	IN
cord-295807-68sukdb1	170	35	tissue	tissue	NN
cord-295807-68sukdb1	170	36	to	to	IN
cord-295807-68sukdb1	170	37	lungs	lung	NNS
cord-295807-68sukdb1	170	38	and	and	CC
cord-295807-68sukdb1	170	39	(	(	-LRB-
cord-295807-68sukdb1	170	40	iii	iii	NN
cord-295807-68sukdb1	170	41	)	)	-RRB-
cord-295807-68sukdb1	170	42	overproduction	overproduction	NN
cord-295807-68sukdb1	170	43	of	of	IN
cord-295807-68sukdb1	170	44	CO2	CO2	NNP
cord-295807-68sukdb1	170	45	.	.	.
cord-295807-68sukdb1	171	1	Reduced	reduce	VBN
cord-295807-68sukdb1	171	2	ventilation	ventilation	NN
cord-295807-68sukdb1	171	3	can	can	MD
cord-295807-68sukdb1	171	4	result	result	VB
cord-295807-68sukdb1	171	5	from	from	IN
cord-295807-68sukdb1	171	6	a	a	DT
cord-295807-68sukdb1	171	7	depression	depression	NN
cord-295807-68sukdb1	171	8	of	of	IN
cord-295807-68sukdb1	171	9	the	the	DT
cord-295807-68sukdb1	171	10	respiratory	respiratory	JJ
cord-295807-68sukdb1	171	11	center	center	NN
cord-295807-68sukdb1	171	12	(	(	-LRB-
cord-295807-68sukdb1	171	13	e.g.	e.g.	RB
cord-295807-68sukdb1	171	14	,	,	,
cord-295807-68sukdb1	171	15	due	due	IN
cord-295807-68sukdb1	171	16	to	to	IN
cord-295807-68sukdb1	171	17	sedative	sedative	JJ
cord-295807-68sukdb1	171	18	overdose	overdose	NN
cord-295807-68sukdb1	171	19	or	or	CC
cord-295807-68sukdb1	171	20	brain	brain	NN
cord-295807-68sukdb1	171	21	injury	injury	NN
cord-295807-68sukdb1	171	22	)	)	-RRB-
cord-295807-68sukdb1	171	23	,	,	,
cord-295807-68sukdb1	171	24	airway	airway	NN
cord-295807-68sukdb1	171	25	obstruction	obstruction	NN
cord-295807-68sukdb1	171	26	(	(	-LRB-
cord-295807-68sukdb1	171	27	e.g.	e.g.	RB
cord-295807-68sukdb1	171	28	,	,	,
cord-295807-68sukdb1	171	29	due	due	IN
cord-295807-68sukdb1	171	30	to	to	TO
cord-295807-68sukdb1	171	31	vomit	vomit	VB
cord-295807-68sukdb1	171	32	aspiration	aspiration	NN
cord-295807-68sukdb1	171	33	or	or	CC
cord-295807-68sukdb1	171	34	laryngospasm	laryngospasm	NN
cord-295807-68sukdb1	171	35	)	)	-RRB-
cord-295807-68sukdb1	171	36	,	,	,
cord-295807-68sukdb1	171	37	neuromuscular	neuromuscular	JJ
cord-295807-68sukdb1	171	38	disorders	disorder	NNS
cord-295807-68sukdb1	171	39	(	(	-LRB-
cord-295807-68sukdb1	171	40	e.g.	e.g.	RB
cord-295807-68sukdb1	171	41	,	,	,
cord-295807-68sukdb1	171	42	due	due	IN
cord-295807-68sukdb1	171	43	to	to	IN
cord-295807-68sukdb1	171	44	Guillain	Guillain	NNP
cord-295807-68sukdb1	171	45	-	-	HYPH
cord-295807-68sukdb1	171	46	Barré	Barré	NNP
cord-295807-68sukdb1	171	47	syndrome	syndrome	NN
cord-295807-68sukdb1	171	48	)	)	-RRB-
cord-295807-68sukdb1	171	49	or	or	CC
cord-295807-68sukdb1	171	50	restrictive	restrictive	JJ
cord-295807-68sukdb1	171	51	defects	defect	NNS
cord-295807-68sukdb1	171	52	of	of	IN
cord-295807-68sukdb1	171	53	the	the	DT
cord-295807-68sukdb1	171	54	chest	chest	NN
cord-295807-68sukdb1	171	55	(	(	-LRB-
cord-295807-68sukdb1	171	56	e.g.	e.g.	RB
cord-295807-68sukdb1	171	57	,	,	,
cord-295807-68sukdb1	171	58	due	due	IN
cord-295807-68sukdb1	171	59	to	to	IN
cord-295807-68sukdb1	171	60	impaired	impaired	JJ
cord-295807-68sukdb1	171	61	functioning	functioning	NN
cord-295807-68sukdb1	171	62	of	of	IN
cord-295807-68sukdb1	171	63	the	the	DT
cord-295807-68sukdb1	171	64	diaphragm	diaphragm	NN
cord-295807-68sukdb1	171	65	)	)	-RRB-
cord-295807-68sukdb1	172	1	[	[	-LRB-
cord-295807-68sukdb1	172	2	83	83	CD
cord-295807-68sukdb1	172	3	]	]	-RRB-
cord-295807-68sukdb1	172	4	.	.	.
cord-295807-68sukdb1	173	1	Defects	defect	NNS
cord-295807-68sukdb1	173	2	of	of	IN
cord-295807-68sukdb1	173	3	CO2	CO2	NNP
cord-295807-68sukdb1	173	4	transport	transport	NN
cord-295807-68sukdb1	173	5	that	that	WDT
cord-295807-68sukdb1	173	6	lead	lead	VBP
cord-295807-68sukdb1	173	7	to	to	IN
cord-295807-68sukdb1	173	8	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	173	9	are	be	VBP
cord-295807-68sukdb1	173	10	less	less	RBR
cord-295807-68sukdb1	173	11	common	common	JJ
cord-295807-68sukdb1	173	12	and	and	CC
cord-295807-68sukdb1	173	13	usually	usually	RB
cord-295807-68sukdb1	173	14	the	the	DT
cord-295807-68sukdb1	173	15	result	result	NN
cord-295807-68sukdb1	173	16	of	of	IN
cord-295807-68sukdb1	173	17	reduced	reduce	VBN
cord-295807-68sukdb1	173	18	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	173	19	perfusion	perfusion	NN
cord-295807-68sukdb1	173	20	in	in	IN
cord-295807-68sukdb1	173	21	response	response	NN
cord-295807-68sukdb1	173	22	,	,	,
cord-295807-68sukdb1	173	23	for	for	IN
cord-295807-68sukdb1	173	24	example	example	NN
cord-295807-68sukdb1	173	25	,	,	,
cord-295807-68sukdb1	173	26	to	to	IN
cord-295807-68sukdb1	173	27	cardiac	cardiac	JJ
cord-295807-68sukdb1	173	28	arrest	arrest	NN
cord-295807-68sukdb1	173	29	or	or	CC
cord-295807-68sukdb1	173	30	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	173	31	embolism	embolism	NN
cord-295807-68sukdb1	173	32	.	.	.
cord-295807-68sukdb1	174	1	Overproduction	overproduction	NN
cord-295807-68sukdb1	174	2	of	of	IN
cord-295807-68sukdb1	174	3	CO2	co2	NN
cord-295807-68sukdb1	174	4	is	be	VBZ
cord-295807-68sukdb1	174	5	rarely	rarely	RB
cord-295807-68sukdb1	174	6	the	the	DT
cord-295807-68sukdb1	174	7	sole	sole	JJ
cord-295807-68sukdb1	174	8	cause	cause	NN
cord-295807-68sukdb1	174	9	of	of	IN
cord-295807-68sukdb1	174	10	RAc	RAc	NNS
cord-295807-68sukdb1	174	11	.	.	.
cord-295807-68sukdb1	175	1	In	in	IN
cord-295807-68sukdb1	175	2	fact	fact	NN
cord-295807-68sukdb1	175	3	,	,	,
cord-295807-68sukdb1	175	4	under	under	IN
cord-295807-68sukdb1	175	5	normal	normal	JJ
cord-295807-68sukdb1	175	6	circumstances	circumstance	NNS
cord-295807-68sukdb1	175	7	the	the	DT
cord-295807-68sukdb1	175	8	body	body	NN
cord-295807-68sukdb1	175	9	responds	respond	VBZ
cord-295807-68sukdb1	175	10	to	to	IN
cord-295807-68sukdb1	175	11	increases	increase	NNS
cord-295807-68sukdb1	175	12	in	in	IN
cord-295807-68sukdb1	175	13	CO2	CO2	NNP
cord-295807-68sukdb1	175	14	production	production	NN
cord-295807-68sukdb1	175	15	by	by	IN
cord-295807-68sukdb1	175	16	appropriately	appropriately	RB
cord-295807-68sukdb1	175	17	increasing	increase	VBG
cord-295807-68sukdb1	175	18	ventilation	ventilation	NN
cord-295807-68sukdb1	175	19	in	in	IN
cord-295807-68sukdb1	175	20	order	order	NN
cord-295807-68sukdb1	175	21	to	to	TO
cord-295807-68sukdb1	175	22	remove	remove	VB
cord-295807-68sukdb1	175	23	the	the	DT
cord-295807-68sukdb1	175	24	excess	excess	JJ
cord-295807-68sukdb1	175	25	CO2	co2	NN
cord-295807-68sukdb1	175	26	and	and	CC
cord-295807-68sukdb1	175	27	prevent	prevent	VB
cord-295807-68sukdb1	175	28	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	175	29	.	.	.
cord-295807-68sukdb1	176	1	Situations	situation	NNS
cord-295807-68sukdb1	176	2	in	in	IN
cord-295807-68sukdb1	176	3	which	which	WDT
cord-295807-68sukdb1	176	4	the	the	DT
cord-295807-68sukdb1	176	5	lungs	lung	NNS
cord-295807-68sukdb1	176	6	are	be	VBP
cord-295807-68sukdb1	176	7	unable	unable	JJ
cord-295807-68sukdb1	176	8	to	to	TO
cord-295807-68sukdb1	176	9	match	match	VB
cord-295807-68sukdb1	176	10	the	the	DT
cord-295807-68sukdb1	176	11	increased	increase	VBN
cord-295807-68sukdb1	176	12	CO2	CO2	NNP
cord-295807-68sukdb1	176	13	production	production	NN
cord-295807-68sukdb1	176	14	can	can	MD
cord-295807-68sukdb1	176	15	occur	occur	VB
cord-295807-68sukdb1	176	16	in	in	IN
cord-295807-68sukdb1	176	17	patients	patient	NNS
cord-295807-68sukdb1	176	18	undergoing	undergo	VBG
cord-295807-68sukdb1	176	19	mechanical	mechanical	JJ
cord-295807-68sukdb1	176	20	ventilation	ventilation	NN
cord-295807-68sukdb1	176	21	or	or	CC
cord-295807-68sukdb1	176	22	with	with	IN
cord-295807-68sukdb1	176	23	reduced	reduce	VBN
cord-295807-68sukdb1	176	24	respiratory	respiratory	JJ
cord-295807-68sukdb1	176	25	reserve	reserve	NN
cord-295807-68sukdb1	176	26	[	[	-LRB-
cord-295807-68sukdb1	176	27	82	82	CD
cord-295807-68sukdb1	176	28	]	]	-RRB-
cord-295807-68sukdb1	176	29	.	.	.
cord-295807-68sukdb1	177	1	In	in	IN
cord-295807-68sukdb1	177	2	fact	fact	NN
cord-295807-68sukdb1	177	3	,	,	,
cord-295807-68sukdb1	177	4	for	for	IN
cord-295807-68sukdb1	177	5	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	177	6	reasons	reason	NNS
cord-295807-68sukdb1	177	7	,	,	,
cord-295807-68sukdb1	177	8	individuals	individual	NNS
cord-295807-68sukdb1	177	9	on	on	IN
cord-295807-68sukdb1	177	10	mechanical	mechanical	JJ
cord-295807-68sukdb1	177	11	ventilation	ventilation	NN
cord-295807-68sukdb1	177	12	are	be	VBP
cord-295807-68sukdb1	177	13	often	often	RB
cord-295807-68sukdb1	177	14	deliberately	deliberately	RB
cord-295807-68sukdb1	177	15	maintained	maintain	VBN
cord-295807-68sukdb1	177	16	in	in	IN
cord-295807-68sukdb1	177	17	a	a	DT
cord-295807-68sukdb1	177	18	state	state	NN
cord-295807-68sukdb1	177	19	of	of	IN
cord-295807-68sukdb1	177	20	'	'	``
cord-295807-68sukdb1	177	21	'	'	``
cord-295807-68sukdb1	177	22	permissive	permissive	JJ
cord-295807-68sukdb1	177	23	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	177	24	'	'	''
cord-295807-68sukdb1	177	25	'	'	''
cord-295807-68sukdb1	178	1	(	(	-LRB-
cord-295807-68sukdb1	178	2	see	see	VB
cord-295807-68sukdb1	178	3	section	section	NN
cord-295807-68sukdb1	178	4	5.2	5.2	CD
cord-295807-68sukdb1	178	5	)	)	-RRB-
cord-295807-68sukdb1	178	6	.	.	.
cord-295807-68sukdb1	179	1	As	as	IN
cord-295807-68sukdb1	179	2	for	for	IN
cord-295807-68sukdb1	179	3	metabolic	metabolic	JJ
cord-295807-68sukdb1	179	4	disturbances	disturbance	NNS
cord-295807-68sukdb1	179	5	,	,	,
cord-295807-68sukdb1	179	6	RAc	RAc	NNS
cord-295807-68sukdb1	179	7	can	can	MD
cord-295807-68sukdb1	179	8	be	be	VB
cord-295807-68sukdb1	179	9	either	either	CC
cord-295807-68sukdb1	179	10	acute	acute	JJ
cord-295807-68sukdb1	179	11	or	or	CC
cord-295807-68sukdb1	179	12	chronic	chronic	JJ
cord-295807-68sukdb1	179	13	.	.	.
cord-295807-68sukdb1	180	1	Acute	acute	JJ
cord-295807-68sukdb1	180	2	RAc	RAc	NNS
cord-295807-68sukdb1	180	3	occurs	occur	VBZ
cord-295807-68sukdb1	180	4	when	when	WRB
cord-295807-68sukdb1	180	5	pCO2	pCO2	NNP
cord-295807-68sukdb1	180	6	rises	rise	VBZ
cord-295807-68sukdb1	180	7	very	very	RB
cord-295807-68sukdb1	180	8	rapidly	rapidly	RB
cord-295807-68sukdb1	180	9	and	and	CC
cord-295807-68sukdb1	180	10	the	the	DT
cord-295807-68sukdb1	180	11	kidneys	kidney	NNS
cord-295807-68sukdb1	180	12	are	be	VBP
cord-295807-68sukdb1	180	13	unable	unable	JJ
cord-295807-68sukdb1	180	14	to	to	TO
cord-295807-68sukdb1	180	15	adequately	adequately	RB
cord-295807-68sukdb1	180	16	increase	increase	VB
cord-295807-68sukdb1	180	17	HCO3production	HCO3production	NNP
cord-295807-68sukdb1	180	18	to	to	TO
cord-295807-68sukdb1	180	19	compensate	compensate	VB
cord-295807-68sukdb1	180	20	in	in	IN
cord-295807-68sukdb1	180	21	such	such	PDT
cord-295807-68sukdb1	180	22	a	a	DT
cord-295807-68sukdb1	180	23	short	short	JJ
cord-295807-68sukdb1	180	24	amount	amount	NN
cord-295807-68sukdb1	180	25	of	of	IN
cord-295807-68sukdb1	180	26	time	time	NN
cord-295807-68sukdb1	180	27	.	.	.
cord-295807-68sukdb1	181	1	Thus	thus	RB
cord-295807-68sukdb1	181	2	,	,	,
cord-295807-68sukdb1	181	3	only	only	RB
cord-295807-68sukdb1	181	4	a	a	DT
cord-295807-68sukdb1	181	5	very	very	RB
cord-295807-68sukdb1	181	6	modest	modest	JJ
cord-295807-68sukdb1	181	7	renal	renal	JJ
cord-295807-68sukdb1	181	8	compensation	compensation	NN
cord-295807-68sukdb1	181	9	occurs	occur	VBZ
cord-295807-68sukdb1	181	10	.	.	.
cord-295807-68sukdb1	182	1	On	on	IN
cord-295807-68sukdb1	182	2	the	the	DT
cord-295807-68sukdb1	182	3	contrary	contrary	NN
cord-295807-68sukdb1	182	4	,	,	,
cord-295807-68sukdb1	182	5	during	during	IN
cord-295807-68sukdb1	182	6	the	the	DT
cord-295807-68sukdb1	182	7	longer	long	JJR
cord-295807-68sukdb1	182	8	timespan	timespan	NN
cord-295807-68sukdb1	182	9	of	of	IN
cord-295807-68sukdb1	182	10	chronic	chronic	JJ
cord-295807-68sukdb1	182	11	RAc	RAc	NNS
cord-295807-68sukdb1	182	12	(	(	-LRB-
cord-295807-68sukdb1	182	13	such	such	JJ
cord-295807-68sukdb1	182	14	as	as	IN
cord-295807-68sukdb1	182	15	with	with	IN
cord-295807-68sukdb1	182	16	chronic	chronic	JJ
cord-295807-68sukdb1	182	17	obstructive	obstructive	JJ
cord-295807-68sukdb1	182	18	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	182	19	disease	disease	NN
cord-295807-68sukdb1	182	20	,	,	,
cord-295807-68sukdb1	182	21	COPD	COPD	NNP
cord-295807-68sukdb1	182	22	)	)	-RRB-
cord-295807-68sukdb1	182	23	,	,	,
cord-295807-68sukdb1	182	24	the	the	DT
cord-295807-68sukdb1	182	25	kidneys	kidney	NNS
cord-295807-68sukdb1	182	26	are	be	VBP
cord-295807-68sukdb1	182	27	able	able	JJ
cord-295807-68sukdb1	182	28	to	to	TO
cord-295807-68sukdb1	182	29	restore	restore	VB
cord-295807-68sukdb1	182	30	the	the	DT
cord-295807-68sukdb1	182	31	acid	acid	NN
cord-295807-68sukdb1	182	32	-	-	HYPH
cord-295807-68sukdb1	182	33	base	base	NN
cord-295807-68sukdb1	182	34	balance	balance	NN
cord-295807-68sukdb1	182	35	by	by	IN
cord-295807-68sukdb1	182	36	increasing	increase	VBG
cord-295807-68sukdb1	182	37	acid	acid	NN
cord-295807-68sukdb1	182	38	excretion	excretion	NN
cord-295807-68sukdb1	182	39	and	and	CC
cord-295807-68sukdb1	182	40	HCO3production	HCO3production	NNP
cord-295807-68sukdb1	182	41	[	[	-LRB-
cord-295807-68sukdb1	182	42	84	84	CD
cord-295807-68sukdb1	182	43	]	]	-RRB-
cord-295807-68sukdb1	182	44	.	.	.
cord-295807-68sukdb1	183	1	Treatment	treatment	NN
cord-295807-68sukdb1	183	2	is	be	VBZ
cord-295807-68sukdb1	183	3	usually	usually	RB
cord-295807-68sukdb1	183	4	directed	direct	VBN
cord-295807-68sukdb1	183	5	towards	towards	IN
cord-295807-68sukdb1	183	6	reversing	reverse	VBG
cord-295807-68sukdb1	183	7	the	the	DT
cord-295807-68sukdb1	183	8	underlying	underlying	JJ
cord-295807-68sukdb1	183	9	cause	cause	NN
cord-295807-68sukdb1	183	10	and	and	CC
cord-295807-68sukdb1	183	11	also	also	RB
cord-295807-68sukdb1	183	12	at	at	IN
cord-295807-68sukdb1	183	13	restoring	restore	VBG
cord-295807-68sukdb1	183	14	adequate	adequate	JJ
cord-295807-68sukdb1	183	15	alveolar	alveolar	NN
cord-295807-68sukdb1	183	16	ventilation	ventilation	NN
cord-295807-68sukdb1	183	17	,	,	,
cord-295807-68sukdb1	183	18	which	which	WDT
cord-295807-68sukdb1	183	19	can	can	MD
cord-295807-68sukdb1	183	20	be	be	VB
cord-295807-68sukdb1	183	21	accomplished	accomplish	VBN
cord-295807-68sukdb1	183	22	by	by	IN
cord-295807-68sukdb1	183	23	endotracheal	endotracheal	JJ
cord-295807-68sukdb1	183	24	intubation	intubation	NN
cord-295807-68sukdb1	183	25	with	with	IN
cord-295807-68sukdb1	183	26	mechanical	mechanical	JJ
cord-295807-68sukdb1	183	27	ventilation	ventilation	NN
cord-295807-68sukdb1	183	28	or	or	CC
cord-295807-68sukdb1	183	29	positive	positive	JJ
cord-295807-68sukdb1	183	30	pressure	pressure	NN
cord-295807-68sukdb1	183	31	ventilation	ventilation	NN
cord-295807-68sukdb1	183	32	[	[	-LRB-
cord-295807-68sukdb1	183	33	85	85	CD
cord-295807-68sukdb1	183	34	]	]	-RRB-
cord-295807-68sukdb1	183	35	.	.	.
cord-295807-68sukdb1	184	1	Because	because	IN
cord-295807-68sukdb1	184	2	the	the	DT
cord-295807-68sukdb1	184	3	sum	sum	NN
cord-295807-68sukdb1	184	4	of	of	IN
cord-295807-68sukdb1	184	5	pCO2	pCO2	NNP
cord-295807-68sukdb1	184	6	and	and	CC
cord-295807-68sukdb1	184	7	pO2	pO2	NNP
cord-295807-68sukdb1	184	8	must	must	MD
cord-295807-68sukdb1	184	9	be	be	VB
cord-295807-68sukdb1	184	10	constant	constant	JJ
cord-295807-68sukdb1	184	11	in	in	IN
cord-295807-68sukdb1	184	12	the	the	DT
cord-295807-68sukdb1	184	13	alveolar	alveolar	JJ
cord-295807-68sukdb1	184	14	gas	gas	NN
cord-295807-68sukdb1	184	15	of	of	IN
cord-295807-68sukdb1	184	16	patients	patient	NNS
cord-295807-68sukdb1	184	17	breathing	breathe	VBG
cord-295807-68sukdb1	184	18	room	room	NN
cord-295807-68sukdb1	184	19	air	air	NN
cord-295807-68sukdb1	184	20	,	,	,
cord-295807-68sukdb1	184	21	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	184	22	leads	lead	VBZ
cord-295807-68sukdb1	184	23	to	to	IN
cord-295807-68sukdb1	184	24	hypoxemia	hypoxemia	NN
cord-295807-68sukdb1	184	25	,	,	,
cord-295807-68sukdb1	184	26	a	a	DT
cord-295807-68sukdb1	184	27	condition	condition	NN
cord-295807-68sukdb1	184	28	that	that	WDT
cord-295807-68sukdb1	184	29	can	can	MD
cord-295807-68sukdb1	184	30	have	have	VB
cord-295807-68sukdb1	184	31	consequences	consequence	NNS
cord-295807-68sukdb1	184	32	far	far	RB
cord-295807-68sukdb1	184	33	more	more	RBR
cord-295807-68sukdb1	184	34	dangerous	dangerous	JJ
cord-295807-68sukdb1	184	35	than	than	IN
cord-295807-68sukdb1	184	36	those	those	DT
cord-295807-68sukdb1	184	37	caused	cause	VBN
cord-295807-68sukdb1	184	38	by	by	IN
cord-295807-68sukdb1	184	39	hypercapnia	hypercapnia	NNP
cord-295807-68sukdb1	184	40	[	[	-LRB-
cord-295807-68sukdb1	184	41	83	83	CD
cord-295807-68sukdb1	184	42	]	]	-RRB-
cord-295807-68sukdb1	184	43	.	.	.
cord-295807-68sukdb1	185	1	Consequently	consequently	RB
cord-295807-68sukdb1	185	2	,	,	,
cord-295807-68sukdb1	185	3	management	management	NN
cord-295807-68sukdb1	185	4	of	of	IN
cord-295807-68sukdb1	185	5	acute	acute	JJ
cord-295807-68sukdb1	185	6	respiratory	respiratory	JJ
cord-295807-68sukdb1	185	7	acidosis	acidosis	NN
cord-295807-68sukdb1	185	8	is	be	VBZ
cord-295807-68sukdb1	185	9	often	often	RB
cord-295807-68sukdb1	185	10	also	also	RB
cord-295807-68sukdb1	185	11	directed	direct	VBN
cord-295807-68sukdb1	185	12	towards	towards	IN
cord-295807-68sukdb1	185	13	ensuring	ensure	VBG
cord-295807-68sukdb1	185	14	adequate	adequate	JJ
cord-295807-68sukdb1	185	15	oxygenation	oxygenation	NN
cord-295807-68sukdb1	185	16	.	.	.
cord-295807-68sukdb1	186	1	Administration	Administration	NNP
cord-295807-68sukdb1	186	2	of	of	IN
cord-295807-68sukdb1	186	3	O2	O2	NNP
cord-295807-68sukdb1	186	4	must	must	MD
cord-295807-68sukdb1	186	5	be	be	VB
cord-295807-68sukdb1	186	6	performed	perform	VBN
cord-295807-68sukdb1	186	7	carefully	carefully	RB
cord-295807-68sukdb1	186	8	because	because	IN
cord-295807-68sukdb1	186	9	it	-PRON-	PRP
cord-295807-68sukdb1	186	10	may	may	MD
cord-295807-68sukdb1	186	11	lead	lead	VB
cord-295807-68sukdb1	186	12	to	to	IN
cord-295807-68sukdb1	186	13	increased	increase	VBN
cord-295807-68sukdb1	186	14	CO2	co2	NN
cord-295807-68sukdb1	186	15	retention	retention	NN
cord-295807-68sukdb1	186	16	,	,	,
cord-295807-68sukdb1	186	17	especially	especially	RB
cord-295807-68sukdb1	186	18	in	in	IN
cord-295807-68sukdb1	186	19	patients	patient	NNS
cord-295807-68sukdb1	186	20	with	with	IN
cord-295807-68sukdb1	186	21	COPD	COPD	NNP
cord-295807-68sukdb1	186	22	[	[	-LRB-
cord-295807-68sukdb1	186	23	82	82	CD
cord-295807-68sukdb1	186	24	]	]	-RRB-
cord-295807-68sukdb1	186	25	.	.	.
cord-295807-68sukdb1	187	1	Correction	correction	NN
cord-295807-68sukdb1	187	2	of	of	IN
cord-295807-68sukdb1	187	3	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	187	4	in	in	IN
cord-295807-68sukdb1	187	5	chronic	chronic	JJ
cord-295807-68sukdb1	187	6	RAc	RAc	NNS
cord-295807-68sukdb1	187	7	usually	usually	RB
cord-295807-68sukdb1	187	8	occurs	occur	VBZ
cord-295807-68sukdb1	187	9	slowly	slowly	RB
cord-295807-68sukdb1	187	10	because	because	IN
cord-295807-68sukdb1	187	11	rapid	rapid	JJ
cord-295807-68sukdb1	187	12	reduction	reduction	NN
cord-295807-68sukdb1	187	13	of	of	IN
cord-295807-68sukdb1	187	14	pCO2	pCO2	NNP
cord-295807-68sukdb1	187	15	can	can	MD
cord-295807-68sukdb1	187	16	lead	lead	VB
cord-295807-68sukdb1	187	17	to	to	TO
cord-295807-68sukdb1	187	18	overshoot	overshoot	VB
cord-295807-68sukdb1	187	19	alkalosis	alkalosis	NN
cord-295807-68sukdb1	187	20	due	due	IN
cord-295807-68sukdb1	187	21	to	to	IN
cord-295807-68sukdb1	187	22	the	the	DT
cord-295807-68sukdb1	187	23	renal	renal	JJ
cord-295807-68sukdb1	187	24	compensation	compensation	NN
cord-295807-68sukdb1	187	25	that	that	WDT
cord-295807-68sukdb1	187	26	increases	increase	VBZ
cord-295807-68sukdb1	187	27	[	[	-LRB-
cord-295807-68sukdb1	187	28	HCO3	HCO3	NNP
cord-295807-68sukdb1	187	29	-	-	,
cord-295807-68sukdb1	187	30	]	]	-RRB-
cord-295807-68sukdb1	187	31	.	.	.
cord-295807-68sukdb1	188	1	In	in	IN
cord-295807-68sukdb1	188	2	the	the	DT
cord-295807-68sukdb1	188	3	central	central	JJ
cord-295807-68sukdb1	188	4	nervous	nervous	JJ
cord-295807-68sukdb1	188	5	system	system	NN
cord-295807-68sukdb1	188	6	(	(	-LRB-
cord-295807-68sukdb1	188	7	CNS	CNS	NNP
cord-295807-68sukdb1	188	8	)	)	-RRB-
cord-295807-68sukdb1	188	9	,	,	,
cord-295807-68sukdb1	188	10	rapid	rapid	JJ
cord-295807-68sukdb1	188	11	alkalinization	alkalinization	NN
cord-295807-68sukdb1	188	12	of	of	IN
cord-295807-68sukdb1	188	13	the	the	DT
cord-295807-68sukdb1	188	14	cerebrospinal	cerebrospinal	JJ
cord-295807-68sukdb1	188	15	fluid	fluid	NN
cord-295807-68sukdb1	188	16	(	(	-LRB-
cord-295807-68sukdb1	188	17	CSF	CSF	NNP
cord-295807-68sukdb1	188	18	)	)	-RRB-
cord-295807-68sukdb1	188	19	can	can	MD
cord-295807-68sukdb1	188	20	cause	cause	VB
cord-295807-68sukdb1	188	21	seizures	seizure	NNS
cord-295807-68sukdb1	188	22	and	and	CC
cord-295807-68sukdb1	188	23	even	even	RB
cord-295807-68sukdb1	188	24	coma	coma	NN
cord-295807-68sukdb1	188	25	[	[	-LRB-
cord-295807-68sukdb1	188	26	82	82	CD
cord-295807-68sukdb1	188	27	]	]	-RRB-
cord-295807-68sukdb1	188	28	.	.	.
cord-295807-68sukdb1	189	1	The	the	DT
cord-295807-68sukdb1	189	2	use	use	NN
cord-295807-68sukdb1	189	3	of	of	IN
cord-295807-68sukdb1	189	4	alkali	alkali	NN
cord-295807-68sukdb1	189	5	therapy	therapy	NN
cord-295807-68sukdb1	189	6	in	in	IN
cord-295807-68sukdb1	189	7	RAc	RAc	NNP
cord-295807-68sukdb1	189	8	is	be	VBZ
cord-295807-68sukdb1	189	9	controversial	controversial	JJ
cord-295807-68sukdb1	189	10	and	and	CC
cord-295807-68sukdb1	189	11	indicated	indicate	VBN
cord-295807-68sukdb1	189	12	only	only	RB
cord-295807-68sukdb1	189	13	in	in	IN
cord-295807-68sukdb1	189	14	patients	patient	NNS
cord-295807-68sukdb1	189	15	with	with	IN
cord-295807-68sukdb1	189	16	acute	acute	JJ
cord-295807-68sukdb1	189	17	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	189	18	and	and	CC
cord-295807-68sukdb1	189	19	concurrent	concurrent	JJ
cord-295807-68sukdb1	189	20	metabolic	metabolic	JJ
cord-295807-68sukdb1	189	21	acidosis	acidosis	NN
cord-295807-68sukdb1	189	22	[	[	-LRB-
cord-295807-68sukdb1	189	23	86	86	CD
cord-295807-68sukdb1	189	24	]	]	-RRB-
cord-295807-68sukdb1	189	25	.	.	.
cord-295807-68sukdb1	190	1	Administration	Administration	NNP
cord-295807-68sukdb1	190	2	of	of	IN
cord-295807-68sukdb1	190	3	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	190	4	is	be	VBZ
cord-295807-68sukdb1	190	5	contraindicated	contraindicated	JJ
cord-295807-68sukdb1	190	6	because	because	IN
cord-295807-68sukdb1	190	7	it	-PRON-	PRP
cord-295807-68sukdb1	190	8	may	may	MD
cord-295807-68sukdb1	190	9	increase	increase	VB
cord-295807-68sukdb1	190	10	CO2	CO2	NNP
cord-295807-68sukdb1	190	11	production	production	NN
cord-295807-68sukdb1	190	12	,	,	,
cord-295807-68sukdb1	190	13	reduce	reduce	VB
cord-295807-68sukdb1	190	14	alveolar	alveolar	NN
cord-295807-68sukdb1	190	15	ventilation	ventilation	NN
cord-295807-68sukdb1	190	16	as	as	RB
cord-295807-68sukdb1	190	17	well	well	RB
cord-295807-68sukdb1	190	18	as	as	IN
cord-295807-68sukdb1	190	19	cause	cause	VB
cord-295807-68sukdb1	190	20	a	a	DT
cord-295807-68sukdb1	190	21	paradoxical	paradoxical	JJ
cord-295807-68sukdb1	190	22	acidosis	acidosis	NN
cord-295807-68sukdb1	190	23	in	in	IN
cord-295807-68sukdb1	190	24	the	the	DT
cord-295807-68sukdb1	190	25	CNS	CNS	NNP
cord-295807-68sukdb1	190	26	.	.	.
cord-295807-68sukdb1	191	1	As	as	IN
cord-295807-68sukdb1	191	2	noted	note	VBN
cord-295807-68sukdb1	191	3	above	above	RB
cord-295807-68sukdb1	191	4	for	for	IN
cord-295807-68sukdb1	191	5	MAc	MAc	NNP
cord-295807-68sukdb1	191	6	,	,	,
cord-295807-68sukdb1	191	7	alterative	alterative	JJ
cord-295807-68sukdb1	191	8	alkali	alkali	NN
cord-295807-68sukdb1	191	9	therapies	therapy	NNS
cord-295807-68sukdb1	191	10	such	such	JJ
cord-295807-68sukdb1	191	11	as	as	IN
cord-295807-68sukdb1	191	12	Carbicarb	Carbicarb	NNP
cord-295807-68sukdb1	191	13	that	that	WDT
cord-295807-68sukdb1	191	14	do	do	VBP
cord-295807-68sukdb1	191	15	not	not	RB
cord-295807-68sukdb1	191	16	generate	generate	VB
cord-295807-68sukdb1	191	17	as	as	RB
cord-295807-68sukdb1	191	18	much	much	JJ
cord-295807-68sukdb1	191	19	CO2	CO2	NNP
cord-295807-68sukdb1	191	20	as	as	IN
cord-295807-68sukdb1	191	21	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	191	22	alone	alone	JJ
cord-295807-68sukdb1	191	23	(	(	-LRB-
cord-295807-68sukdb1	191	24	see	see	VB
cord-295807-68sukdb1	191	25	section	section	NN
cord-295807-68sukdb1	191	26	3.2.2	3.2.2	CD
cord-295807-68sukdb1	191	27	)	)	-RRB-
cord-295807-68sukdb1	191	28	may	may	MD
cord-295807-68sukdb1	191	29	be	be	VB
cord-295807-68sukdb1	191	30	preferable	preferable	JJ
cord-295807-68sukdb1	191	31	to	to	TO
cord-295807-68sukdb1	191	32	correct	correct	VB
cord-295807-68sukdb1	191	33	pH	ph	NN
cord-295807-68sukdb1	191	34	in	in	IN
cord-295807-68sukdb1	191	35	RAc	RAc	NNS
cord-295807-68sukdb1	191	36	.	.	.
cord-295807-68sukdb1	192	1	In	in	IN
cord-295807-68sukdb1	192	2	patients	patient	NNS
cord-295807-68sukdb1	192	3	with	with	IN
cord-295807-68sukdb1	192	4	COPD	COPD	NNP
cord-295807-68sukdb1	192	5	,	,	,
cord-295807-68sukdb1	192	6	the	the	DT
cord-295807-68sukdb1	192	7	CA	CA	NNP
cord-295807-68sukdb1	192	8	inhibitor	inhibitor	NN
cord-295807-68sukdb1	192	9	ACZ	ACZ	NNP
cord-295807-68sukdb1	192	10	is	be	VBZ
cord-295807-68sukdb1	192	11	sometimes	sometimes	RB
cord-295807-68sukdb1	192	12	used	use	VBN
cord-295807-68sukdb1	192	13	to	to	TO
cord-295807-68sukdb1	192	14	stimulate	stimulate	VB
cord-295807-68sukdb1	192	15	respiration	respiration	NN
cord-295807-68sukdb1	192	16	in	in	IN
cord-295807-68sukdb1	192	17	order	order	NN
cord-295807-68sukdb1	192	18	to	to	TO
cord-295807-68sukdb1	192	19	improve	improve	VB
cord-295807-68sukdb1	192	20	oxygenation	oxygenation	NN
cord-295807-68sukdb1	192	21	,	,	,
cord-295807-68sukdb1	192	22	reduce	reduce	VB
cord-295807-68sukdb1	192	23	CO2	co2	NN
cord-295807-68sukdb1	192	24	retention	retention	NN
cord-295807-68sukdb1	192	25	and	and	CC
cord-295807-68sukdb1	192	26	possibly	possibly	RB
cord-295807-68sukdb1	192	27	remove	remove	VB
cord-295807-68sukdb1	192	28	the	the	DT
cord-295807-68sukdb1	192	29	need	need	NN
cord-295807-68sukdb1	192	30	for	for	IN
cord-295807-68sukdb1	192	31	mechanical	mechanical	JJ
cord-295807-68sukdb1	192	32	ventilation	ventilation	NN
cord-295807-68sukdb1	192	33	[	[	-LRB-
cord-295807-68sukdb1	192	34	87	87	CD
cord-295807-68sukdb1	192	35	]	]	-RRB-
cord-295807-68sukdb1	192	36	.	.	.
cord-295807-68sukdb1	193	1	However	however	RB
cord-295807-68sukdb1	193	2	,	,	,
cord-295807-68sukdb1	193	3	because	because	IN
cord-295807-68sukdb1	193	4	CA	CA	NNP
cord-295807-68sukdb1	193	5	is	be	VBZ
cord-295807-68sukdb1	193	6	ubiquitous	ubiquitous	JJ
cord-295807-68sukdb1	193	7	,	,	,
cord-295807-68sukdb1	193	8	the	the	DT
cord-295807-68sukdb1	193	9	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	193	10	effect	effect	NN
cord-295807-68sukdb1	193	11	of	of	IN
cord-295807-68sukdb1	193	12	ACZ	ACZ	NNP
cord-295807-68sukdb1	193	13	may	may	MD
cord-295807-68sukdb1	193	14	impact	impact	VB
cord-295807-68sukdb1	193	15	a	a	DT
cord-295807-68sukdb1	193	16	variety	variety	NN
cord-295807-68sukdb1	193	17	of	of	IN
cord-295807-68sukdb1	193	18	tissues	tissue	NNS
cord-295807-68sukdb1	193	19	and	and	CC
cord-295807-68sukdb1	193	20	have	have	VBP
cord-295807-68sukdb1	193	21	potential	potential	JJ
cord-295807-68sukdb1	193	22	negative	negative	JJ
cord-295807-68sukdb1	193	23	consequences	consequence	NNS
cord-295807-68sukdb1	193	24	on	on	IN
cord-295807-68sukdb1	193	25	patients	patient	NNS
cord-295807-68sukdb1	193	26	with	with	IN
cord-295807-68sukdb1	193	27	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	193	28	diseases	disease	NNS
cord-295807-68sukdb1	193	29	.	.	.
cord-295807-68sukdb1	194	1	For	for	IN
cord-295807-68sukdb1	194	2	this	this	DT
cord-295807-68sukdb1	194	3	reason	reason	NN
cord-295807-68sukdb1	194	4	the	the	DT
cord-295807-68sukdb1	194	5	role	role	NN
cord-295807-68sukdb1	194	6	of	of	IN
cord-295807-68sukdb1	194	7	ACZ	ACZ	NNP
cord-295807-68sukdb1	194	8	as	as	IN
cord-295807-68sukdb1	194	9	a	a	DT
cord-295807-68sukdb1	194	10	respiratory	respiratory	JJ
cord-295807-68sukdb1	194	11	stimulant	stimulant	NN
cord-295807-68sukdb1	194	12	is	be	VBZ
cord-295807-68sukdb1	194	13	controversial	controversial	JJ
cord-295807-68sukdb1	194	14	,	,	,
cord-295807-68sukdb1	194	15	especially	especially	RB
cord-295807-68sukdb1	194	16	in	in	IN
cord-295807-68sukdb1	194	17	patients	patient	NNS
cord-295807-68sukdb1	194	18	with	with	IN
cord-295807-68sukdb1	194	19	severe	severe	JJ
cord-295807-68sukdb1	194	20	COPD	COPD	NNP
cord-295807-68sukdb1	194	21	with	with	IN
cord-295807-68sukdb1	194	22	or	or	CC
cord-295807-68sukdb1	194	23	without	without	IN
cord-295807-68sukdb1	194	24	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	194	25	[	[	-LRB-
cord-295807-68sukdb1	194	26	87	87	CD
cord-295807-68sukdb1	194	27	]	]	-RRB-
cord-295807-68sukdb1	194	28	.	.	.
cord-295807-68sukdb1	195	1	Finally	finally	RB
cord-295807-68sukdb1	195	2	,	,	,
cord-295807-68sukdb1	195	3	CO2	CO2	NNP
cord-295807-68sukdb1	195	4	can	can	MD
cord-295807-68sukdb1	195	5	be	be	VB
cord-295807-68sukdb1	195	6	de	de	VBN
cord-295807-68sukdb1	195	7	-	-	VBN
cord-295807-68sukdb1	195	8	gassed	gas	VBN
cord-295807-68sukdb1	195	9	from	from	IN
cord-295807-68sukdb1	195	10	blood	blood	NN
cord-295807-68sukdb1	195	11	using	use	VBG
cord-295807-68sukdb1	195	12	an	an	DT
cord-295807-68sukdb1	195	13	extracorporeal	extracorporeal	JJ
cord-295807-68sukdb1	195	14	CO2	co2	NN
cord-295807-68sukdb1	195	15	removal	removal	NN
cord-295807-68sukdb1	195	16	(	(	-LRB-
cord-295807-68sukdb1	195	17	ECCO2R	ecco2r	NN
cord-295807-68sukdb1	195	18	)	)	-RRB-
cord-295807-68sukdb1	195	19	device	device	NN
cord-295807-68sukdb1	195	20	or	or	CC
cord-295807-68sukdb1	195	21	[	[	-LRB-
cord-295807-68sukdb1	195	22	88	88	CD
cord-295807-68sukdb1	195	23	]	]	-RRB-
cord-295807-68sukdb1	195	24	lowered	lower	VBN
cord-295807-68sukdb1	195	25	by	by	IN
cord-295807-68sukdb1	195	26	dialysis	dialysis	NN
cord-295807-68sukdb1	195	27	using	use	VBG
cord-295807-68sukdb1	195	28	a	a	DT
cord-295807-68sukdb1	195	29	dialysate	dialysate	NN
cord-295807-68sukdb1	195	30	that	that	WDT
cord-295807-68sukdb1	195	31	has	have	VBZ
cord-295807-68sukdb1	195	32	a	a	DT
cord-295807-68sukdb1	195	33	low	low	JJ
cord-295807-68sukdb1	195	34	[	[	-LRB-
cord-295807-68sukdb1	195	35	HCO3	HCO3	NNP
cord-295807-68sukdb1	195	36	-	-	,
cord-295807-68sukdb1	195	37	]	]	-RRB-
cord-295807-68sukdb1	195	38	[	[	-LRB-
cord-295807-68sukdb1	195	39	89	89	CD
cord-295807-68sukdb1	195	40	]	]	-RRB-
cord-295807-68sukdb1	195	41	.	.	.
cord-295807-68sukdb1	196	1	RAlk	ralk	JJ
cord-295807-68sukdb1	196	2	refers	refer	VBZ
cord-295807-68sukdb1	196	3	to	to	IN
cord-295807-68sukdb1	196	4	alkalemia	alkalemia	VB
cord-295807-68sukdb1	196	5	with	with	IN
cord-295807-68sukdb1	196	6	a	a	DT
cord-295807-68sukdb1	196	7	plasma	plasma	NN
cord-295807-68sukdb1	196	8	pCO2	pco2	IN
cord-295807-68sukdb1	196	9	<	<	XX
cord-295807-68sukdb1	196	10	35	35	CD
cord-295807-68sukdb1	196	11	mmHg	mmHg	NNS
cord-295807-68sukdb1	196	12	at	at	IN
cord-295807-68sukdb1	196	13	rest	rest	NN
cord-295807-68sukdb1	196	14	and	and	CC
cord-295807-68sukdb1	196	15	sea	sea	NN
cord-295807-68sukdb1	196	16	level	level	NN
cord-295807-68sukdb1	196	17	[	[	-LRB-
cord-295807-68sukdb1	196	18	82	82	CD
cord-295807-68sukdb1	196	19	]	]	-RRB-
cord-295807-68sukdb1	196	20	.	.	.
cord-295807-68sukdb1	197	1	It	-PRON-	PRP
cord-295807-68sukdb1	197	2	occurs	occur	VBZ
cord-295807-68sukdb1	197	3	when	when	WRB
cord-295807-68sukdb1	197	4	the	the	DT
cord-295807-68sukdb1	197	5	ventilatory	ventilatory	NN
cord-295807-68sukdb1	197	6	system	system	NN
cord-295807-68sukdb1	197	7	does	do	VBZ
cord-295807-68sukdb1	197	8	not	not	RB
cord-295807-68sukdb1	197	9	work	work	VB
cord-295807-68sukdb1	197	10	properly	properly	RB
cord-295807-68sukdb1	197	11	causing	cause	VBG
cord-295807-68sukdb1	197	12	an	an	DT
cord-295807-68sukdb1	197	13	increase	increase	NN
cord-295807-68sukdb1	197	14	in	in	IN
cord-295807-68sukdb1	197	15	alveolar	alveolar	JJ
cord-295807-68sukdb1	197	16	ventilation	ventilation	NN
cord-295807-68sukdb1	197	17	and/or	and/or	CC
cord-295807-68sukdb1	197	18	reduced	reduce	VBN
cord-295807-68sukdb1	197	19	CO2	co2	NN
cord-295807-68sukdb1	197	20	production	production	NN
cord-295807-68sukdb1	197	21	with	with	IN
cord-295807-68sukdb1	197	22	consequent	consequent	JJ
cord-295807-68sukdb1	197	23	CO2	co2	NN
cord-295807-68sukdb1	197	24	depletion	depletion	NN
cord-295807-68sukdb1	197	25	in	in	IN
cord-295807-68sukdb1	197	26	the	the	DT
cord-295807-68sukdb1	197	27	blood	blood	NN
cord-295807-68sukdb1	197	28	.	.	.
cord-295807-68sukdb1	198	1	Hyperventilation	hyperventilation	NN
cord-295807-68sukdb1	198	2	can	can	MD
cord-295807-68sukdb1	198	3	result	result	VB
cord-295807-68sukdb1	198	4	from	from	IN
cord-295807-68sukdb1	198	5	stimulation	stimulation	NN
cord-295807-68sukdb1	198	6	of	of	IN
cord-295807-68sukdb1	198	7	the	the	DT
cord-295807-68sukdb1	198	8	respiratory	respiratory	JJ
cord-295807-68sukdb1	198	9	centers	center	NNS
cord-295807-68sukdb1	198	10	(	(	-LRB-
cord-295807-68sukdb1	198	11	e.g.	e.g.	RB
cord-295807-68sukdb1	198	12	,	,	,
cord-295807-68sukdb1	198	13	due	due	IN
cord-295807-68sukdb1	198	14	to	to	IN
cord-295807-68sukdb1	198	15	drugs	drug	NNS
cord-295807-68sukdb1	198	16	or	or	CC
cord-295807-68sukdb1	198	17	disorders	disorder	NNS
cord-295807-68sukdb1	198	18	of	of	IN
cord-295807-68sukdb1	198	19	the	the	DT
cord-295807-68sukdb1	198	20	CNS	CNS	NNP
cord-295807-68sukdb1	198	21	)	)	-RRB-
cord-295807-68sukdb1	198	22	,	,	,
cord-295807-68sukdb1	198	23	hypoxemia	hypoxemia	NN
cord-295807-68sukdb1	198	24	or	or	CC
cord-295807-68sukdb1	198	25	tissue	tissue	NN
cord-295807-68sukdb1	198	26	hypoxia	hypoxia	NN
cord-295807-68sukdb1	198	27	(	(	-LRB-
cord-295807-68sukdb1	198	28	e.g.	e.g.	RB
cord-295807-68sukdb1	198	29	,	,	,
cord-295807-68sukdb1	198	30	due	due	IN
cord-295807-68sukdb1	198	31	to	to	IN
cord-295807-68sukdb1	198	32	high	high	JJ
cord-295807-68sukdb1	198	33	altitude	altitude	NN
cord-295807-68sukdb1	198	34	)	)	-RRB-
cord-295807-68sukdb1	198	35	,	,	,
cord-295807-68sukdb1	198	36	lung	lung	NN
cord-295807-68sukdb1	198	37	diseases	disease	NNS
cord-295807-68sukdb1	198	38	(	(	-LRB-
cord-295807-68sukdb1	198	39	e.g.	e.g.	RB
cord-295807-68sukdb1	198	40	,	,	,
cord-295807-68sukdb1	198	41	pneumonia	pneumonia	NN
cord-295807-68sukdb1	198	42	)	)	-RRB-
cord-295807-68sukdb1	198	43	.	.	.
cord-295807-68sukdb1	199	1	Reduced	reduce	VBN
cord-295807-68sukdb1	199	2	CO2	co2	NN
cord-295807-68sukdb1	199	3	production	production	NN
cord-295807-68sukdb1	199	4	can	can	MD
cord-295807-68sukdb1	199	5	result	result	VB
cord-295807-68sukdb1	199	6	from	from	IN
cord-295807-68sukdb1	199	7	a	a	DT
cord-295807-68sukdb1	199	8	decrease	decrease	NN
cord-295807-68sukdb1	199	9	in	in	IN
cord-295807-68sukdb1	199	10	the	the	DT
cord-295807-68sukdb1	199	11	basal	basal	NN
cord-295807-68sukdb1	199	12	metabolic	metabolic	JJ
cord-295807-68sukdb1	199	13	rate	rate	NN
cord-295807-68sukdb1	199	14	(	(	-LRB-
cord-295807-68sukdb1	199	15	e.g.	e.g.	RB
cord-295807-68sukdb1	199	16	,	,	,
cord-295807-68sukdb1	199	17	due	due	IN
cord-295807-68sukdb1	199	18	to	to	IN
cord-295807-68sukdb1	199	19	hypothermia	hypothermia	NN
cord-295807-68sukdb1	199	20	)	)	-RRB-
cord-295807-68sukdb1	199	21	or	or	CC
cord-295807-68sukdb1	199	22	in	in	IN
cord-295807-68sukdb1	199	23	physical	physical	JJ
cord-295807-68sukdb1	199	24	activity	activity	NN
cord-295807-68sukdb1	199	25	(	(	-LRB-
cord-295807-68sukdb1	199	26	e.g.	e.g.	RB
cord-295807-68sukdb1	199	27	,	,	,
cord-295807-68sukdb1	199	28	due	due	IN
cord-295807-68sukdb1	199	29	to	to	IN
cord-295807-68sukdb1	199	30	muscle	muscle	NN
cord-295807-68sukdb1	199	31	paralysis	paralysis	NN
cord-295807-68sukdb1	199	32	)	)	-RRB-
cord-295807-68sukdb1	199	33	.	.	.
cord-295807-68sukdb1	200	1	Clinical	clinical	JJ
cord-295807-68sukdb1	200	2	manifestations	manifestation	NNS
cord-295807-68sukdb1	200	3	can	can	MD
cord-295807-68sukdb1	200	4	include	include	VB
cord-295807-68sukdb1	200	5	rapid	rapid	JJ
cord-295807-68sukdb1	200	6	breathing	breathing	NN
cord-295807-68sukdb1	200	7	and	and	CC
cord-295807-68sukdb1	200	8	dizziness	dizziness	NN
cord-295807-68sukdb1	200	9	[	[	-LRB-
cord-295807-68sukdb1	200	10	58	58	CD
cord-295807-68sukdb1	200	11	]	]	-RRB-
cord-295807-68sukdb1	200	12	.	.	.
cord-295807-68sukdb1	201	1	Although	although	IN
cord-295807-68sukdb1	201	2	usually	usually	RB
cord-295807-68sukdb1	201	3	considered	consider	VBN
cord-295807-68sukdb1	201	4	not	not	RB
cord-295807-68sukdb1	201	5	life	life	NN
cord-295807-68sukdb1	201	6	-	-	HYPH
cord-295807-68sukdb1	201	7	threatening	threaten	VBG
cord-295807-68sukdb1	201	8	,	,	,
cord-295807-68sukdb1	201	9	severe	severe	JJ
cord-295807-68sukdb1	201	10	RAlk	ralk	NN
cord-295807-68sukdb1	201	11	can	can	MD
cord-295807-68sukdb1	201	12	have	have	VB
cord-295807-68sukdb1	201	13	serious	serious	JJ
cord-295807-68sukdb1	201	14	consequences	consequence	NNS
cord-295807-68sukdb1	201	15	on	on	IN
cord-295807-68sukdb1	201	16	the	the	DT
cord-295807-68sukdb1	201	17	brain	brain	NN
cord-295807-68sukdb1	201	18	,	,	,
cord-295807-68sukdb1	201	19	lungs	lung	NNS
cord-295807-68sukdb1	201	20	and	and	CC
cord-295807-68sukdb1	201	21	the	the	DT
cord-295807-68sukdb1	201	22	heart	heart	NN
cord-295807-68sukdb1	201	23	.	.	.
cord-295807-68sukdb1	202	1	Treatment	treatment	NN
cord-295807-68sukdb1	202	2	is	be	VBZ
cord-295807-68sukdb1	202	3	usually	usually	RB
cord-295807-68sukdb1	202	4	directed	direct	VBN
cord-295807-68sukdb1	202	5	towards	towards	IN
cord-295807-68sukdb1	202	6	correcting	correct	VBG
cord-295807-68sukdb1	202	7	the	the	DT
cord-295807-68sukdb1	202	8	underlying	underlie	VBG
cord-295807-68sukdb1	202	9	disorders	disorder	NNS
cord-295807-68sukdb1	202	10	.	.	.
cord-295807-68sukdb1	203	1	Hormone	hormone	NN
cord-295807-68sukdb1	203	2	replacement	replacement	NN
cord-295807-68sukdb1	203	3	therapy	therapy	NN
cord-295807-68sukdb1	203	4	caused	cause	VBD
cord-295807-68sukdb1	203	5	RAlk	RAlk	NNP
cord-295807-68sukdb1	203	6	in	in	IN
cord-295807-68sukdb1	203	7	a	a	DT
cord-295807-68sukdb1	203	8	study	study	NN
cord-295807-68sukdb1	203	9	of	of	IN
cord-295807-68sukdb1	203	10	postmenopausal	postmenopausal	JJ
cord-295807-68sukdb1	203	11	women	woman	NNS
cord-295807-68sukdb1	203	12	[	[	-LRB-
cord-295807-68sukdb1	203	13	90	90	CD
cord-295807-68sukdb1	203	14	]	]	-RRB-
cord-295807-68sukdb1	203	15	.	.	.
cord-295807-68sukdb1	204	1	Abrupt	abrupt	JJ
cord-295807-68sukdb1	204	2	correction	correction	NN
cord-295807-68sukdb1	204	3	of	of	IN
cord-295807-68sukdb1	204	4	severe	severe	JJ
cord-295807-68sukdb1	204	5	RAlk	ralk	NN
cord-295807-68sukdb1	204	6	should	should	MD
cord-295807-68sukdb1	204	7	be	be	VB
cord-295807-68sukdb1	204	8	avoided	avoid	VBN
cord-295807-68sukdb1	204	9	because	because	IN
cord-295807-68sukdb1	204	10	of	of	IN
cord-295807-68sukdb1	204	11	the	the	DT
cord-295807-68sukdb1	204	12	risks	risk	NNS
cord-295807-68sukdb1	204	13	of	of	IN
cord-295807-68sukdb1	204	14	cerebral	cerebral	JJ
cord-295807-68sukdb1	204	15	and	and	CC
cord-295807-68sukdb1	204	16	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	204	17	reperfusion	reperfusion	NN
cord-295807-68sukdb1	204	18	injury	injury	NN
cord-295807-68sukdb1	204	19	.	.	.
cord-295807-68sukdb1	205	1	ACZ	ACZ	NNP
cord-295807-68sukdb1	205	2	is	be	VBZ
cord-295807-68sukdb1	205	3	used	use	VBN
cord-295807-68sukdb1	205	4	in	in	IN
cord-295807-68sukdb1	205	5	the	the	DT
cord-295807-68sukdb1	205	6	prevention	prevention	NN
cord-295807-68sukdb1	205	7	and	and	CC
cord-295807-68sukdb1	205	8	treatment	treatment	NN
cord-295807-68sukdb1	205	9	of	of	IN
cord-295807-68sukdb1	205	10	RAlk	ralk	JJ
cord-295807-68sukdb1	205	11	associated	associate	VBN
cord-295807-68sukdb1	205	12	with	with	IN
cord-295807-68sukdb1	205	13	hyperventilation	hyperventilation	NN
cord-295807-68sukdb1	205	14	at	at	IN
cord-295807-68sukdb1	205	15	high	high	JJ
cord-295807-68sukdb1	205	16	altitude	altitude	NN
cord-295807-68sukdb1	205	17	(	(	-LRB-
cord-295807-68sukdb1	205	18	acute	acute	JJ
cord-295807-68sukdb1	205	19	mountain	mountain	NN
cord-295807-68sukdb1	205	20	sickness	sickness	NN
cord-295807-68sukdb1	205	21	:	:	:
cord-295807-68sukdb1	205	22	AMS	AMS	NNP
cord-295807-68sukdb1	205	23	)	)	-RRB-
cord-295807-68sukdb1	205	24	in	in	IN
cord-295807-68sukdb1	205	25	part	part	NN
cord-295807-68sukdb1	205	26	because	because	IN
cord-295807-68sukdb1	205	27	it	-PRON-	PRP
cord-295807-68sukdb1	205	28	enhances	enhance	VBZ
cord-295807-68sukdb1	205	29	HCO3excretion	HCO3excretion	NNP
cord-295807-68sukdb1	205	30	in	in	IN
cord-295807-68sukdb1	205	31	the	the	DT
cord-295807-68sukdb1	205	32	urine	urine	NN
cord-295807-68sukdb1	205	33	,	,	,
cord-295807-68sukdb1	205	34	providing	provide	VBG
cord-295807-68sukdb1	205	35	a	a	DT
cord-295807-68sukdb1	205	36	compensatory	compensatory	JJ
cord-295807-68sukdb1	205	37	lower	low	JJR
cord-295807-68sukdb1	205	38	of	of	IN
cord-295807-68sukdb1	205	39	pH	pH	NNP
cord-295807-68sukdb1	205	40	[	[	-LRB-
cord-295807-68sukdb1	205	41	91	91	CD
cord-295807-68sukdb1	205	42	]	]	-RRB-
cord-295807-68sukdb1	205	43	.	.	.
cord-295807-68sukdb1	206	1	Neuronal	neuronal	JJ
cord-295807-68sukdb1	206	2	activity	activity	NN
cord-295807-68sukdb1	206	3	presents	present	VBZ
cord-295807-68sukdb1	206	4	a	a	DT
cord-295807-68sukdb1	206	5	substantial	substantial	JJ
cord-295807-68sukdb1	206	6	challenge	challenge	NN
cord-295807-68sukdb1	206	7	to	to	IN
cord-295807-68sukdb1	206	8	local	local	JJ
cord-295807-68sukdb1	206	9	acid	acid	NN
cord-295807-68sukdb1	206	10	-	-	HYPH
cord-295807-68sukdb1	206	11	base	base	NN
cord-295807-68sukdb1	206	12	balance	balance	NN
cord-295807-68sukdb1	206	13	.	.	.
cord-295807-68sukdb1	207	1	Neurotransmitterfilled	neurotransmitterfilled	JJ
cord-295807-68sukdb1	207	2	vesicles	vesicle	NNS
cord-295807-68sukdb1	207	3	release	release	VBP
cord-295807-68sukdb1	207	4	H	H	NNP
cord-295807-68sukdb1	207	5	+	+	CC
cord-295807-68sukdb1	207	6	into	into	IN
cord-295807-68sukdb1	207	7	the	the	DT
cord-295807-68sukdb1	207	8	synaptic	synaptic	JJ
cord-295807-68sukdb1	207	9	cleft	cleft	NN
cord-295807-68sukdb1	207	10	[	[	-LRB-
cord-295807-68sukdb1	207	11	92	92	CD
cord-295807-68sukdb1	207	12	,	,	,
cord-295807-68sukdb1	207	13	93	93	CD
cord-295807-68sukdb1	207	14	]	]	-RRB-
cord-295807-68sukdb1	208	1	(	(	-LRB-
cord-295807-68sukdb1	208	2	H	h	NN
cord-295807-68sukdb1	208	3	+	+	CC
cord-295807-68sukdb1	208	4	themselves	-PRON-	PRP
cord-295807-68sukdb1	208	5	may	may	MD
cord-295807-68sukdb1	208	6	be	be	VB
cord-295807-68sukdb1	208	7	considered	consider	VBN
cord-295807-68sukdb1	208	8	to	to	TO
cord-295807-68sukdb1	208	9	be	be	VB
cord-295807-68sukdb1	208	10	neurotransmitters	neurotransmitter	NNS
cord-295807-68sukdb1	208	11	[	[	-LRB-
cord-295807-68sukdb1	208	12	94	94	CD
cord-295807-68sukdb1	208	13	]	]	-RRB-
cord-295807-68sukdb1	208	14	)	)	-RRB-
cord-295807-68sukdb1	208	15	and	and	CC
cord-295807-68sukdb1	208	16	are	be	VBP
cord-295807-68sukdb1	208	17	removed	remove	VBN
cord-295807-68sukdb1	208	18	from	from	IN
cord-295807-68sukdb1	208	19	the	the	DT
cord-295807-68sukdb1	208	20	synaptic	synaptic	JJ
cord-295807-68sukdb1	208	21	cleft	cleft	NN
cord-295807-68sukdb1	208	22	by	by	IN
cord-295807-68sukdb1	208	23	H	H	NNP
cord-295807-68sukdb1	208	24	+	+	CC
cord-295807-68sukdb1	208	25	-coupled	-coupled	JJ
cord-295807-68sukdb1	208	26	neurotransmitter	neurotransmitter	NN
cord-295807-68sukdb1	208	27	transporters	transporter	NNS
cord-295807-68sukdb1	208	28	such	such	JJ
cord-295807-68sukdb1	208	29	as	as	IN
cord-295807-68sukdb1	208	30	the	the	DT
cord-295807-68sukdb1	208	31	excitatory	excitatory	JJ
cord-295807-68sukdb1	208	32	amino	amino	NN
cord-295807-68sukdb1	208	33	acid	acid	NN
cord-295807-68sukdb1	208	34	transporter	transporter	NN
cord-295807-68sukdb1	208	35	EAAT1	eaat1	NN
cord-295807-68sukdb1	208	36	.	.	.
cord-295807-68sukdb1	209	1	GABA	GABA	NNP
cord-295807-68sukdb1	209	2	-	-	HYPH
cord-295807-68sukdb1	209	3	activated	activate	VBN
cord-295807-68sukdb1	209	4	anion	anion	NN
cord-295807-68sukdb1	209	5	channels	channel	NNS
cord-295807-68sukdb1	209	6	in	in	IN
cord-295807-68sukdb1	209	7	neurons	neuron	NNS
cord-295807-68sukdb1	209	8	and	and	CC
cord-295807-68sukdb1	209	9	astrocytes	astrocyte	NNS
cord-295807-68sukdb1	209	10	release	release	VBP
cord-295807-68sukdb1	209	11	HCO3	HCO3	NNP
cord-295807-68sukdb1	209	12	-	-	HYPH
cord-295807-68sukdb1	209	13	[	[	-LRB-
cord-295807-68sukdb1	209	14	95	95	CD
cord-295807-68sukdb1	209	15	,	,	,
cord-295807-68sukdb1	209	16	96	96	CD
cord-295807-68sukdb1	209	17	]	]	-RRB-
cord-295807-68sukdb1	209	18	,	,	,
cord-295807-68sukdb1	209	19	and	and	CC
cord-295807-68sukdb1	209	20	the	the	DT
cord-295807-68sukdb1	210	1	Ca	ca	NN
cord-295807-68sukdb1	210	2	2	2	CD
cord-295807-68sukdb1	210	3	+	+	CD
cord-295807-68sukdb1	211	1	/H	/H	NNP
cord-295807-68sukdb1	211	2	+	+	CC
cord-295807-68sukdb1	211	3	exchange	exchange	NN
cord-295807-68sukdb1	211	4	activity	activity	NN
cord-295807-68sukdb1	211	5	of	of	IN
cord-295807-68sukdb1	211	6	the	the	DT
cord-295807-68sukdb1	211	7	plasma	plasma	NN
cord-295807-68sukdb1	211	8	membrane	membrane	NN
cord-295807-68sukdb1	212	1	Ca	ca	RB
cord-295807-68sukdb1	212	2	2	2	CD
cord-295807-68sukdb1	213	1	+	+	CC
cord-295807-68sukdb1	214	1	-ATPase	-ATPase	NNP
cord-295807-68sukdb1	215	1	(	(	-LRB-
cord-295807-68sukdb1	215	2	PMCA	PMCA	NNP
cord-295807-68sukdb1	215	3	)	)	-RRB-
cord-295807-68sukdb1	216	1	in	in	IN
cord-295807-68sukdb1	216	2	neurons	neuron	NNS
cord-295807-68sukdb1	216	3	causes	cause	VBZ
cord-295807-68sukdb1	216	4	a	a	DT
cord-295807-68sukdb1	216	5	rise	rise	NN
cord-295807-68sukdb1	216	6	in	in	IN
cord-295807-68sukdb1	216	7	extracellular	extracellular	JJ
cord-295807-68sukdb1	216	8	pH	ph	NN
cord-295807-68sukdb1	216	9	as	as	IN
cord-295807-68sukdb1	216	10	it	-PRON-	PRP
cord-295807-68sukdb1	216	11	restores	restore	VBZ
cord-295807-68sukdb1	216	12	intracellular	intracellular	JJ
cord-295807-68sukdb1	217	1	Ca	ca	RB
cord-295807-68sukdb1	217	2	2	2	CD
cord-295807-68sukdb1	218	1	+	+	CC
cord-295807-68sukdb1	218	2	following	follow	VBG
cord-295807-68sukdb1	218	3	an	an	DT
cord-295807-68sukdb1	218	4	action	action	NN
cord-295807-68sukdb1	218	5	potential	potential	NN
cord-295807-68sukdb1	218	6	[	[	-LRB-
cord-295807-68sukdb1	218	7	97	97	CD
cord-295807-68sukdb1	218	8	]	]	-RRB-
cord-295807-68sukdb1	218	9	.	.	.
cord-295807-68sukdb1	219	1	The	the	DT
cord-295807-68sukdb1	219	2	acid	acid	NN
cord-295807-68sukdb1	219	3	load	load	NN
cord-295807-68sukdb1	219	4	that	that	WDT
cord-295807-68sukdb1	219	5	results	result	VBZ
cord-295807-68sukdb1	219	6	from	from	IN
cord-295807-68sukdb1	219	7	intensive	intensive	JJ
cord-295807-68sukdb1	219	8	neuronal	neuronal	JJ
cord-295807-68sukdb1	219	9	firing	firing	NN
cord-295807-68sukdb1	219	10	can	can	MD
cord-295807-68sukdb1	219	11	result	result	VB
cord-295807-68sukdb1	219	12	in	in	IN
cord-295807-68sukdb1	219	13	a	a	DT
cord-295807-68sukdb1	219	14	drop	drop	NN
cord-295807-68sukdb1	219	15	in	in	IN
cord-295807-68sukdb1	219	16	pHi	pHi	NNS
cord-295807-68sukdb1	219	17	that	that	WDT
cord-295807-68sukdb1	219	18	dampens	dampen	VBZ
cord-295807-68sukdb1	219	19	neuronal	neuronal	JJ
cord-295807-68sukdb1	219	20	activity	activity	NN
cord-295807-68sukdb1	219	21	:	:	:
cord-295807-68sukdb1	219	22	a	a	DT
cord-295807-68sukdb1	219	23	mechanism	mechanism	NN
cord-295807-68sukdb1	219	24	that	that	WDT
cord-295807-68sukdb1	219	25	prevents	prevent	VBZ
cord-295807-68sukdb1	219	26	excessive	excessive	JJ
cord-295807-68sukdb1	219	27	firing	firing	NN
cord-295807-68sukdb1	219	28	via	via	IN
cord-295807-68sukdb1	219	29	effects	effect	NNS
cord-295807-68sukdb1	219	30	upon	upon	IN
cord-295807-68sukdb1	219	31	pH	ph	JJ
cord-295807-68sukdb1	219	32	-	-	JJ
cord-295807-68sukdb1	219	33	sensitive	sensitive	JJ
cord-295807-68sukdb1	219	34	channels	channel	NNS
cord-295807-68sukdb1	219	35	such	such	JJ
cord-295807-68sukdb1	219	36	as	as	IN
cord-295807-68sukdb1	219	37	ASIC1a	ASIC1a	NNP
cord-295807-68sukdb1	219	38	and	and	CC
cord-295807-68sukdb1	219	39	NMDA	NMDA	NNP
cord-295807-68sukdb1	219	40	receptors	receptor	NNS
cord-295807-68sukdb1	219	41	[	[	-LRB-
cord-295807-68sukdb1	219	42	98	98	CD
cord-295807-68sukdb1	219	43	]	]	-RRB-
cord-295807-68sukdb1	220	1	[	[	-LRB-
cord-295807-68sukdb1	220	2	99	99	CD
cord-295807-68sukdb1	220	3	]	]	-RRB-
cord-295807-68sukdb1	220	4	[	[	-LRB-
cord-295807-68sukdb1	220	5	100	100	CD
cord-295807-68sukdb1	220	6	]	]	-RRB-
cord-295807-68sukdb1	220	7	.	.	.
cord-295807-68sukdb1	221	1	Conversely	conversely	RB
cord-295807-68sukdb1	221	2	,	,	,
cord-295807-68sukdb1	221	3	alkalosis	alkalosis	NN
cord-295807-68sukdb1	221	4	is	be	VBZ
cord-295807-68sukdb1	221	5	associated	associate	VBN
cord-295807-68sukdb1	221	6	with	with	IN
cord-295807-68sukdb1	221	7	an	an	DT
cord-295807-68sukdb1	221	8	increase	increase	NN
cord-295807-68sukdb1	221	9	in	in	IN
cord-295807-68sukdb1	221	10	neuronal	neuronal	JJ
cord-295807-68sukdb1	221	11	activity	activity	NN
cord-295807-68sukdb1	221	12	and	and	CC
cord-295807-68sukdb1	221	13	seizures	seizure	NNS
cord-295807-68sukdb1	221	14	[	[	-LRB-
cord-295807-68sukdb1	221	15	101	101	CD
cord-295807-68sukdb1	221	16	]	]	-RRB-
cord-295807-68sukdb1	221	17	.	.	.
cord-295807-68sukdb1	222	1	Neurons	neuron	NNS
cord-295807-68sukdb1	222	2	and	and	CC
cord-295807-68sukdb1	222	3	astrocytes	astrocyte	NNS
cord-295807-68sukdb1	222	4	express	express	VBP
cord-295807-68sukdb1	222	5	numerous	numerous	JJ
cord-295807-68sukdb1	222	6	ABTs	abt	NNS
cord-295807-68sukdb1	222	7	and	and	CC
cord-295807-68sukdb1	222	8	CAs	CAs	NNP
cord-295807-68sukdb1	222	9	to	to	TO
cord-295807-68sukdb1	222	10	maintain	maintain	VB
cord-295807-68sukdb1	222	11	pH	pH	NNP
cord-295807-68sukdb1	222	12	homeostasis	homeostasis	NN
cord-295807-68sukdb1	222	13	and	and	CC
cord-295807-68sukdb1	222	14	their	-PRON-	PRP$
cord-295807-68sukdb1	222	15	importance	importance	NN
cord-295807-68sukdb1	222	16	is	be	VBZ
cord-295807-68sukdb1	222	17	highlighted	highlight	VBN
cord-295807-68sukdb1	222	18	by	by	IN
cord-295807-68sukdb1	222	19	the	the	DT
cord-295807-68sukdb1	222	20	effects	effect	NNS
cord-295807-68sukdb1	222	21	of	of	IN
cord-295807-68sukdb1	222	22	their	-PRON-	PRP$
cord-295807-68sukdb1	222	23	disruption	disruption	NN
cord-295807-68sukdb1	222	24	[	[	-LRB-
cord-295807-68sukdb1	222	25	102	102	CD
cord-295807-68sukdb1	222	26	]	]	-RRB-
cord-295807-68sukdb1	222	27	.	.	.
cord-295807-68sukdb1	223	1	For	for	IN
cord-295807-68sukdb1	223	2	example	example	NN
cord-295807-68sukdb1	223	3	,	,	,
cord-295807-68sukdb1	223	4	genetic	genetic	JJ
cord-295807-68sukdb1	223	5	disruptions	disruption	NNS
cord-295807-68sukdb1	223	6	in	in	IN
cord-295807-68sukdb1	223	7	AE3	AE3	NNS
cord-295807-68sukdb1	223	8	or	or	CC
cord-295807-68sukdb1	223	9	NBCn2	NBCn2	NNP
cord-295807-68sukdb1	223	10	are	be	VBP
cord-295807-68sukdb1	223	11	associated	associate	VBN
cord-295807-68sukdb1	223	12	with	with	IN
cord-295807-68sukdb1	223	13	epilepsy	epilepsy	NN
cord-295807-68sukdb1	223	14	[	[	-LRB-
cord-295807-68sukdb1	223	15	103	103	CD
cord-295807-68sukdb1	223	16	,	,	,
cord-295807-68sukdb1	223	17	104	104	CD
cord-295807-68sukdb1	223	18	]	]	-RRB-
cord-295807-68sukdb1	223	19	,	,	,
cord-295807-68sukdb1	223	20	although	although	IN
cord-295807-68sukdb1	223	21	the	the	DT
cord-295807-68sukdb1	223	22	mechanism	mechanism	NN
cord-295807-68sukdb1	223	23	is	be	VBZ
cord-295807-68sukdb1	223	24	not	not	RB
cord-295807-68sukdb1	223	25	simply	simply	RB
cord-295807-68sukdb1	223	26	related	relate	VBN
cord-295807-68sukdb1	223	27	to	to	IN
cord-295807-68sukdb1	223	28	effects	effect	NNS
cord-295807-68sukdb1	223	29	of	of	IN
cord-295807-68sukdb1	223	30	neuronal	neuronal	JJ
cord-295807-68sukdb1	223	31	pHi	pHi	NNS
cord-295807-68sukdb1	223	32	on	on	IN
cord-295807-68sukdb1	223	33	excitability	excitability	NN
cord-295807-68sukdb1	223	34	as	as	IN
cord-295807-68sukdb1	223	35	AE3	AE3	NNP
cord-295807-68sukdb1	223	36	is	be	VBZ
cord-295807-68sukdb1	223	37	an	an	DT
cord-295807-68sukdb1	223	38	acidloader	acidloader	NN
cord-295807-68sukdb1	223	39	while	while	IN
cord-295807-68sukdb1	223	40	NBCn2	NBCn2	NNP
cord-295807-68sukdb1	223	41	is	be	VBZ
cord-295807-68sukdb1	223	42	an	an	DT
cord-295807-68sukdb1	223	43	acid	acid	NN
cord-295807-68sukdb1	223	44	extruder	extruder	NN
cord-295807-68sukdb1	223	45	and	and	CC
cord-295807-68sukdb1	223	46	may	may	MD
cord-295807-68sukdb1	223	47	depend	depend	VB
cord-295807-68sukdb1	223	48	on	on	IN
cord-295807-68sukdb1	223	49	whether	whether	IN
cord-295807-68sukdb1	223	50	the	the	DT
cord-295807-68sukdb1	223	51	neurons	neuron	NNS
cord-295807-68sukdb1	223	52	in	in	IN
cord-295807-68sukdb1	223	53	question	question	NN
cord-295807-68sukdb1	223	54	are	be	VBP
cord-295807-68sukdb1	223	55	excitatory	excitatory	JJ
cord-295807-68sukdb1	223	56	or	or	CC
cord-295807-68sukdb1	223	57	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	223	58	.	.	.
cord-295807-68sukdb1	224	1	Several	several	JJ
cord-295807-68sukdb1	224	2	ABTs	abt	NNS
cord-295807-68sukdb1	224	3	and	and	CC
cord-295807-68sukdb1	224	4	CAs	CAs	NNP
cord-295807-68sukdb1	224	5	are	be	VBP
cord-295807-68sukdb1	224	6	expressed	express	VBN
cord-295807-68sukdb1	224	7	in	in	IN
cord-295807-68sukdb1	224	8	the	the	DT
cord-295807-68sukdb1	224	9	choroid	choroid	JJ
cord-295807-68sukdb1	224	10	plexus	plexus	NN
cord-295807-68sukdb1	224	11	epithelia	epithelium	NNS
cord-295807-68sukdb1	224	12	where	where	WRB
cord-295807-68sukdb1	224	13	their	-PRON-	PRP$
cord-295807-68sukdb1	224	14	action	action	NN
cord-295807-68sukdb1	224	15	supports	support	VBZ
cord-295807-68sukdb1	224	16	the	the	DT
cord-295807-68sukdb1	224	17	secretion	secretion	NN
cord-295807-68sukdb1	224	18	of	of	IN
cord-295807-68sukdb1	224	19	cerebrospinal	cerebrospinal	NN
cord-295807-68sukdb1	224	20	fluid	fluid	NN
cord-295807-68sukdb1	224	21	(	(	-LRB-
cord-295807-68sukdb1	224	22	CSF	CSF	NNP
cord-295807-68sukdb1	224	23	)	)	-RRB-
cord-295807-68sukdb1	224	24	.	.	.
cord-295807-68sukdb1	225	1	Genetic	genetic	JJ
cord-295807-68sukdb1	225	2	ablation	ablation	NN
cord-295807-68sukdb1	225	3	of	of	IN
cord-295807-68sukdb1	225	4	these	these	DT
cord-295807-68sukdb1	225	5	transporters	transporter	NNS
cord-295807-68sukdb1	225	6	(	(	-LRB-
cord-295807-68sukdb1	225	7	e.g.	e.g.	RB
cord-295807-68sukdb1	225	8	,	,	,
cord-295807-68sukdb1	225	9	NBCn2	NBCn2	NNP
cord-295807-68sukdb1	225	10	,	,	,
cord-295807-68sukdb1	225	11	NBCe2	NBCe2	NNP
cord-295807-68sukdb1	225	12	)	)	-RRB-
cord-295807-68sukdb1	225	13	in	in	IN
cord-295807-68sukdb1	225	14	rodents	rodent	NNS
cord-295807-68sukdb1	225	15	is	be	VBZ
cord-295807-68sukdb1	225	16	linked	link	VBN
cord-295807-68sukdb1	225	17	to	to	IN
cord-295807-68sukdb1	225	18	reductions	reduction	NNS
cord-295807-68sukdb1	225	19	in	in	IN
cord-295807-68sukdb1	225	20	ventricle	ventricle	NN
cord-295807-68sukdb1	225	21	fluid	fluid	NN
cord-295807-68sukdb1	225	22	volume	volume	NN
cord-295807-68sukdb1	225	23	[	[	-LRB-
cord-295807-68sukdb1	225	24	105	105	CD
cord-295807-68sukdb1	225	25	]	]	-RRB-
cord-295807-68sukdb1	225	26	while	while	IN
cord-295807-68sukdb1	225	27	pharmacological	pharmacological	JJ
cord-295807-68sukdb1	225	28	inhibition	inhibition	NN
cord-295807-68sukdb1	225	29	of	of	IN
cord-295807-68sukdb1	225	30	CAs	CAs	NNP
cord-295807-68sukdb1	225	31	results	result	NNS
cord-295807-68sukdb1	225	32	in	in	IN
cord-295807-68sukdb1	225	33	reduction	reduction	NN
cord-295807-68sukdb1	225	34	of	of	IN
cord-295807-68sukdb1	225	35	intracranial	intracranial	JJ
cord-295807-68sukdb1	225	36	pressure	pressure	NN
cord-295807-68sukdb1	225	37	[	[	-LRB-
cord-295807-68sukdb1	225	38	106	106	CD
cord-295807-68sukdb1	225	39	]	]	-RRB-
cord-295807-68sukdb1	225	40	.	.	.
cord-295807-68sukdb1	226	1	However	however	RB
cord-295807-68sukdb1	226	2	,	,	,
cord-295807-68sukdb1	226	3	it	-PRON-	PRP
cord-295807-68sukdb1	226	4	is	be	VBZ
cord-295807-68sukdb1	226	5	unclear	unclear	JJ
cord-295807-68sukdb1	226	6	whether	whether	IN
cord-295807-68sukdb1	226	7	these	these	DT
cord-295807-68sukdb1	226	8	changes	change	NNS
cord-295807-68sukdb1	226	9	are	be	VBP
cord-295807-68sukdb1	226	10	accompanied	accompany	VBN
cord-295807-68sukdb1	226	11	by	by	IN
cord-295807-68sukdb1	226	12	a	a	DT
cord-295807-68sukdb1	226	13	fall	fall	NN
cord-295807-68sukdb1	226	14	in	in	IN
cord-295807-68sukdb1	226	15	pH	ph	NN
cord-295807-68sukdb1	226	16	of	of	IN
cord-295807-68sukdb1	226	17	the	the	DT
cord-295807-68sukdb1	226	18	CSF	CSF	NNP
cord-295807-68sukdb1	226	19	.	.	.
cord-295807-68sukdb1	227	1	Besides	besides	IN
cord-295807-68sukdb1	227	2	its	-PRON-	PRP$
cord-295807-68sukdb1	227	3	role	role	NN
cord-295807-68sukdb1	227	4	in	in	IN
cord-295807-68sukdb1	227	5	determining	determine	VBG
cord-295807-68sukdb1	227	6	pH	ph	NN
cord-295807-68sukdb1	227	7	,	,	,
cord-295807-68sukdb1	227	8	HCO3plays	HCO3plays	NNP
cord-295807-68sukdb1	227	9	an	an	DT
cord-295807-68sukdb1	227	10	important	important	JJ
cord-295807-68sukdb1	227	11	role	role	NN
cord-295807-68sukdb1	227	12	in	in	IN
cord-295807-68sukdb1	227	13	neuronal	neuronal	JJ
cord-295807-68sukdb1	227	14	plasticity	plasticity	NN
cord-295807-68sukdb1	227	15	because	because	IN
cord-295807-68sukdb1	227	16	the	the	DT
cord-295807-68sukdb1	227	17	transmembrane	transmembrane	NN
cord-295807-68sukdb1	227	18	gradients	gradient	NNS
cord-295807-68sukdb1	227	19	of	of	IN
cord-295807-68sukdb1	227	20	Cland	Cland	NNP
cord-295807-68sukdb1	227	21	HCO3determine	HCO3determine	NNP
cord-295807-68sukdb1	227	22	the	the	DT
cord-295807-68sukdb1	227	23	reversal	reversal	NN
cord-295807-68sukdb1	227	24	potential	potential	NN
cord-295807-68sukdb1	227	25	of	of	IN
cord-295807-68sukdb1	227	26	GABAactivated	gabaactivated	JJ
cord-295807-68sukdb1	227	27	channels	channel	NNS
cord-295807-68sukdb1	227	28	and	and	CC
cord-295807-68sukdb1	227	29	consequently	consequently	RB
cord-295807-68sukdb1	227	30	whether	whether	IN
cord-295807-68sukdb1	227	31	GABAergic	gabaergic	NN
cord-295807-68sukdb1	227	32	signals	signal	NNS
cord-295807-68sukdb1	227	33	are	be	VBP
cord-295807-68sukdb1	227	34	depolarizing	depolarizing	JJ
cord-295807-68sukdb1	227	35	and	and	CC
cord-295807-68sukdb1	227	36	excitatory	excitatory	JJ
cord-295807-68sukdb1	227	37	or	or	CC
cord-295807-68sukdb1	227	38	hyperpolarizing	hyperpolarizing	NN
cord-295807-68sukdb1	227	39	and	and	CC
cord-295807-68sukdb1	227	40	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	227	41	[	[	-LRB-
cord-295807-68sukdb1	227	42	107	107	CD
cord-295807-68sukdb1	227	43	]	]	-RRB-
cord-295807-68sukdb1	227	44	.	.	.
cord-295807-68sukdb1	228	1	Changes	change	NNS
cord-295807-68sukdb1	228	2	in	in	IN
cord-295807-68sukdb1	228	3	these	these	DT
cord-295807-68sukdb1	228	4	gradients	gradient	NNS
cord-295807-68sukdb1	228	5	are	be	VBP
cord-295807-68sukdb1	228	6	important	important	JJ
cord-295807-68sukdb1	228	7	in	in	IN
cord-295807-68sukdb1	228	8	two	two	CD
cord-295807-68sukdb1	228	9	ways	way	NNS
cord-295807-68sukdb1	228	10	.	.	.
cord-295807-68sukdb1	229	1	Firstly	firstly	RB
cord-295807-68sukdb1	229	2	,	,	,
cord-295807-68sukdb1	229	3	developmental	developmental	JJ
cord-295807-68sukdb1	229	4	changes	change	NNS
cord-295807-68sukdb1	229	5	in	in	IN
cord-295807-68sukdb1	229	6	the	the	DT
cord-295807-68sukdb1	229	7	gradient	gradient	NN
cord-295807-68sukdb1	229	8	during	during	IN
cord-295807-68sukdb1	229	9	central	central	JJ
cord-295807-68sukdb1	229	10	nervous	nervous	JJ
cord-295807-68sukdb1	229	11	system	system	NN
cord-295807-68sukdb1	229	12	maturation	maturation	NN
cord-295807-68sukdb1	229	13	promote	promote	VBP
cord-295807-68sukdb1	229	14	the	the	DT
cord-295807-68sukdb1	229	15	switch	switch	NN
cord-295807-68sukdb1	229	16	to	to	IN
cord-295807-68sukdb1	229	17	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	229	18	GABA	GABA	NNP
cord-295807-68sukdb1	229	19	signaling	signal	VBG
cord-295807-68sukdb1	229	20	[	[	-LRB-
cord-295807-68sukdb1	229	21	108	108	CD
cord-295807-68sukdb1	229	22	]	]	-RRB-
cord-295807-68sukdb1	229	23	.	.	.
cord-295807-68sukdb1	230	1	Secondly	secondly	RB
cord-295807-68sukdb1	230	2	,	,	,
cord-295807-68sukdb1	230	3	activity	activity	NN
cord-295807-68sukdb1	230	4	-	-	HYPH
cord-295807-68sukdb1	230	5	dependent	dependent	JJ
cord-295807-68sukdb1	230	6	changes	change	NNS
cord-295807-68sukdb1	230	7	in	in	IN
cord-295807-68sukdb1	230	8	the	the	DT
cord-295807-68sukdb1	230	9	gradient	gradient	NN
cord-295807-68sukdb1	230	10	contribute	contribute	VB
cord-295807-68sukdb1	230	11	to	to	IN
cord-295807-68sukdb1	230	12	the	the	DT
cord-295807-68sukdb1	230	13	pathophysiology	pathophysiology	NN
cord-295807-68sukdb1	230	14	of	of	IN
cord-295807-68sukdb1	230	15	epilepsy	epilepsy	NN
cord-295807-68sukdb1	230	16	by	by	IN
cord-295807-68sukdb1	230	17	promoting	promote	VBG
cord-295807-68sukdb1	230	18	a	a	DT
cord-295807-68sukdb1	230	19	pathological	pathological	JJ
cord-295807-68sukdb1	230	20	switch	switch	NN
cord-295807-68sukdb1	230	21	to	to	IN
cord-295807-68sukdb1	230	22	excitatory	excitatory	JJ
cord-295807-68sukdb1	230	23	GABA	GABA	NNP
cord-295807-68sukdb1	230	24	signaling	signal	VBG
cord-295807-68sukdb1	230	25	[	[	-LRB-
cord-295807-68sukdb1	230	26	107	107	CD
cord-295807-68sukdb1	230	27	]	]	-RRB-
cord-295807-68sukdb1	230	28	.	.	.
cord-295807-68sukdb1	231	1	Neuronal	neuronal	JJ
cord-295807-68sukdb1	231	2	Cl	Cl	NNP
cord-295807-68sukdb1	231	3	−	−	NNP
cord-295807-68sukdb1	231	4	-HCO3	-HCO3	NNP
cord-295807-68sukdb1	231	5	−	−	NNP
cord-295807-68sukdb1	231	6	exchangers	exchanger	NNS
cord-295807-68sukdb1	231	7	such	such	JJ
cord-295807-68sukdb1	231	8	as	as	IN
cord-295807-68sukdb1	231	9	AE3	AE3	NNS
cord-295807-68sukdb1	231	10	and	and	CC
cord-295807-68sukdb1	231	11	NDCBE	NDCBE	NNP
cord-295807-68sukdb1	231	12	are	be	VBP
cord-295807-68sukdb1	231	13	likely	likely	JJ
cord-295807-68sukdb1	231	14	to	to	TO
cord-295807-68sukdb1	231	15	contribute	contribute	VB
cord-295807-68sukdb1	231	16	to	to	IN
cord-295807-68sukdb1	231	17	the	the	DT
cord-295807-68sukdb1	231	18	status	status	NN
cord-295807-68sukdb1	231	19	of	of	IN
cord-295807-68sukdb1	231	20	these	these	DT
cord-295807-68sukdb1	231	21	gradients	gradient	NNS
cord-295807-68sukdb1	231	22	[	[	-LRB-
cord-295807-68sukdb1	231	23	109	109	CD
cord-295807-68sukdb1	231	24	]	]	-RRB-
cord-295807-68sukdb1	231	25	.	.	.
cord-295807-68sukdb1	232	1	Finally	finally	RB
cord-295807-68sukdb1	232	2	,	,	,
cord-295807-68sukdb1	232	3	mutations	mutation	NNS
cord-295807-68sukdb1	232	4	in	in	IN
cord-295807-68sukdb1	232	5	endosomal	endosomal	JJ
cord-295807-68sukdb1	232	6	NHE6	NHE6	NNP
cord-295807-68sukdb1	232	7	cause	cause	VB
cord-295807-68sukdb1	232	8	intellectual	intellectual	JJ
cord-295807-68sukdb1	232	9	disability	disability	NN
cord-295807-68sukdb1	232	10	and	and	CC
cord-295807-68sukdb1	232	11	are	be	VBP
cord-295807-68sukdb1	232	12	associated	associate	VBN
cord-295807-68sukdb1	232	13	with	with	IN
cord-295807-68sukdb1	232	14	defective	defective	JJ
cord-295807-68sukdb1	232	15	synaptic	synaptic	JJ
cord-295807-68sukdb1	232	16	remodeling	remodeling	NN
cord-295807-68sukdb1	232	17	[	[	-LRB-
cord-295807-68sukdb1	232	18	110	110	CD
cord-295807-68sukdb1	232	19	]	]	-RRB-
cord-295807-68sukdb1	232	20	.	.	.
cord-295807-68sukdb1	233	1	Acidosis	acidosis	NN
cord-295807-68sukdb1	233	2	has	have	VBZ
cord-295807-68sukdb1	233	3	a	a	DT
cord-295807-68sukdb1	233	4	number	number	NN
cord-295807-68sukdb1	233	5	of	of	IN
cord-295807-68sukdb1	233	6	other	other	JJ
cord-295807-68sukdb1	233	7	consequences	consequence	NNS
cord-295807-68sukdb1	233	8	.	.	.
cord-295807-68sukdb1	234	1	For	for	IN
cord-295807-68sukdb1	234	2	example	example	NN
cord-295807-68sukdb1	234	3	in	in	IN
cord-295807-68sukdb1	234	4	stroke	stroke	NN
cord-295807-68sukdb1	234	5	,	,	,
cord-295807-68sukdb1	234	6	lactic	lactic	JJ
cord-295807-68sukdb1	234	7	acidosis	acidosis	NN
cord-295807-68sukdb1	234	8	is	be	VBZ
cord-295807-68sukdb1	234	9	linked	link	VBN
cord-295807-68sukdb1	234	10	to	to	IN
cord-295807-68sukdb1	234	11	ischemic	ischemic	JJ
cord-295807-68sukdb1	234	12	damage	damage	NN
cord-295807-68sukdb1	234	13	[	[	-LRB-
cord-295807-68sukdb1	234	14	111	111	CD
cord-295807-68sukdb1	234	15	]	]	-RRB-
cord-295807-68sukdb1	234	16	.	.	.
cord-295807-68sukdb1	235	1	In	in	IN
cord-295807-68sukdb1	235	2	protein	protein	NN
cord-295807-68sukdb1	235	3	-	-	HYPH
cord-295807-68sukdb1	235	4	aggregating	aggregate	VBG
cord-295807-68sukdb1	235	5	neurodegenerative	neurodegenerative	JJ
cord-295807-68sukdb1	235	6	diseases	disease	NNS
cord-295807-68sukdb1	235	7	,	,	,
cord-295807-68sukdb1	235	8	acidic	acidic	JJ
cord-295807-68sukdb1	235	9	pH	pH	NNP
cord-295807-68sukdb1	235	10	promotes	promote	VBZ
cord-295807-68sukdb1	235	11	the	the	DT
cord-295807-68sukdb1	235	12	aggregation	aggregation	NN
cord-295807-68sukdb1	235	13	of	of	IN
cord-295807-68sukdb1	235	14	Alzheimer	Alzheimer	NNP
cord-295807-68sukdb1	235	15	's	's	POS
cord-295807-68sukdb1	235	16	amyloid	amyloid	NN
cord-295807-68sukdb1	235	17	proteins	protein	NNS
cord-295807-68sukdb1	235	18	[	[	-LRB-
cord-295807-68sukdb1	235	19	112	112	CD
cord-295807-68sukdb1	235	20	]	]	-RRB-
cord-295807-68sukdb1	235	21	.	.	.
cord-295807-68sukdb1	236	1	A	a	DT
cord-295807-68sukdb1	236	2	major	major	JJ
cord-295807-68sukdb1	236	3	genetic	genetic	JJ
cord-295807-68sukdb1	236	4	risk	risk	NN
cord-295807-68sukdb1	236	5	factor	factor	NN
cord-295807-68sukdb1	236	6	for	for	IN
cord-295807-68sukdb1	236	7	Alzheimer	Alzheimer	NNP
cord-295807-68sukdb1	236	8	's	's	POS
cord-295807-68sukdb1	236	9	Disease	Disease	NNP
cord-295807-68sukdb1	236	10	is	be	VBZ
cord-295807-68sukdb1	236	11	incidence	incidence	NN
cord-295807-68sukdb1	236	12	of	of	IN
cord-295807-68sukdb1	236	13	the	the	DT
cord-295807-68sukdb1	236	14	apolipoprotein	apolipoprotein	NN
cord-295807-68sukdb1	236	15	E	e	NN
cord-295807-68sukdb1	236	16	allelic	allelic	JJ
cord-295807-68sukdb1	236	17	variant	variant	NN
cord-295807-68sukdb1	236	18	ApoE4	ApoE4	NNP
cord-295807-68sukdb1	236	19	,	,	,
cord-295807-68sukdb1	236	20	which	which	WDT
cord-295807-68sukdb1	236	21	causes	cause	VBZ
cord-295807-68sukdb1	236	22	the	the	DT
cord-295807-68sukdb1	236	23	epigenetic	epigenetic	JJ
cord-295807-68sukdb1	236	24	downregulation	downregulation	NN
cord-295807-68sukdb1	236	25	of	of	IN
cord-295807-68sukdb1	236	26	NHE6	NHE6	NNP
cord-295807-68sukdb1	236	27	[	[	-LRB-
cord-295807-68sukdb1	236	28	113	113	CD
cord-295807-68sukdb1	236	29	]	]	-RRB-
cord-295807-68sukdb1	236	30	.	.	.
cord-295807-68sukdb1	237	1	Loss	loss	NN
cord-295807-68sukdb1	237	2	of	of	IN
cord-295807-68sukdb1	237	3	NHE6	NHE6	NNP
cord-295807-68sukdb1	237	4	from	from	IN
cord-295807-68sukdb1	237	5	endosomes	endosome	NNS
cord-295807-68sukdb1	237	6	causes	cause	VBZ
cord-295807-68sukdb1	237	7	aberrant	aberrant	JJ
cord-295807-68sukdb1	237	8	acidification	acidification	NN
cord-295807-68sukdb1	237	9	and	and	CC
cord-295807-68sukdb1	237	10	defective	defective	JJ
cord-295807-68sukdb1	237	11	clearance	clearance	NN
cord-295807-68sukdb1	237	12	of	of	IN
cord-295807-68sukdb1	237	13	amyloid	amyloid	NN
cord-295807-68sukdb1	237	14	deposits	deposit	NNS
cord-295807-68sukdb1	237	15	[	[	-LRB-
cord-295807-68sukdb1	237	16	113	113	CD
cord-295807-68sukdb1	237	17	]	]	-RRB-
cord-295807-68sukdb1	237	18	.	.	.
cord-295807-68sukdb1	238	1	Brain	brain	NN
cord-295807-68sukdb1	238	2	acid	acid	NN
cord-295807-68sukdb1	238	3	-	-	HYPH
cord-295807-68sukdb1	238	4	base	base	NN
cord-295807-68sukdb1	238	5	status	status	NN
cord-295807-68sukdb1	238	6	also	also	RB
cord-295807-68sukdb1	238	7	has	have	VBZ
cord-295807-68sukdb1	238	8	consequences	consequence	NNS
cord-295807-68sukdb1	238	9	for	for	IN
cord-295807-68sukdb1	238	10	mental	mental	JJ
cord-295807-68sukdb1	238	11	health	health	NN
cord-295807-68sukdb1	238	12	(	(	-LRB-
cord-295807-68sukdb1	238	13	see	see	VB
cord-295807-68sukdb1	238	14	Mental	Mental	NNP
cord-295807-68sukdb1	238	15	Health	Health	NNP
cord-295807-68sukdb1	238	16	)	)	-RRB-
cord-295807-68sukdb1	238	17	.	.	.
cord-295807-68sukdb1	239	1	The	the	DT
cord-295807-68sukdb1	239	2	role	role	NN
cord-295807-68sukdb1	239	3	of	of	IN
cord-295807-68sukdb1	239	4	pH	ph	NN
cord-295807-68sukdb1	239	5	in	in	IN
cord-295807-68sukdb1	239	6	the	the	DT
cord-295807-68sukdb1	239	7	retina	retina	NN
cord-295807-68sukdb1	239	8	is	be	VBZ
cord-295807-68sukdb1	239	9	considered	consider	VBN
cord-295807-68sukdb1	239	10	in	in	IN
cord-295807-68sukdb1	239	11	a	a	DT
cord-295807-68sukdb1	239	12	later	later	JJ
cord-295807-68sukdb1	239	13	section	section	NN
cord-295807-68sukdb1	239	14	(	(	-LRB-
cord-295807-68sukdb1	239	15	see	see	VB
cord-295807-68sukdb1	239	16	The	the	DT
cord-295807-68sukdb1	239	17	Sensory	Sensory	NNP
cord-295807-68sukdb1	239	18	Systems	Systems	NNPS
cord-295807-68sukdb1	239	19	)	)	-RRB-
cord-295807-68sukdb1	239	20	.	.	.
cord-295807-68sukdb1	240	1	The	the	DT
cord-295807-68sukdb1	240	2	link	link	NN
cord-295807-68sukdb1	240	3	between	between	IN
cord-295807-68sukdb1	240	4	pH	ph	NN
cord-295807-68sukdb1	240	5	and	and	CC
cord-295807-68sukdb1	240	6	neuronal	neuronal	JJ
cord-295807-68sukdb1	240	7	excitability	excitability	NN
cord-295807-68sukdb1	240	8	is	be	VBZ
cord-295807-68sukdb1	240	9	exploited	exploit	VBN
cord-295807-68sukdb1	240	10	in	in	IN
cord-295807-68sukdb1	240	11	the	the	DT
cord-295807-68sukdb1	240	12	anticonvulsant	anticonvulsant	JJ
cord-295807-68sukdb1	240	13	value	value	NN
cord-295807-68sukdb1	240	14	of	of	IN
cord-295807-68sukdb1	240	15	inhaled	inhale	VBN
cord-295807-68sukdb1	240	16	5	5	CD
cord-295807-68sukdb1	240	17	%	%	NN
cord-295807-68sukdb1	240	18	CO2	co2	NN
cord-295807-68sukdb1	240	19	to	to	TO
cord-295807-68sukdb1	240	20	induce	induce	VB
cord-295807-68sukdb1	240	21	hypercapnic	hypercapnic	NNP
cord-295807-68sukdb1	240	22	acidosis	acidosis	NN
cord-295807-68sukdb1	240	23	[	[	-LRB-
cord-295807-68sukdb1	240	24	114	114	CD
cord-295807-68sukdb1	240	25	]	]	-RRB-
cord-295807-68sukdb1	240	26	.	.	.
cord-295807-68sukdb1	241	1	Hypercapnia	Hypercapnia	NNP
cord-295807-68sukdb1	241	2	also	also	RB
cord-295807-68sukdb1	241	3	has	have	VBZ
cord-295807-68sukdb1	241	4	a	a	DT
cord-295807-68sukdb1	241	5	neuroprotective	neuroprotective	JJ
cord-295807-68sukdb1	241	6	role	role	NN
cord-295807-68sukdb1	241	7	in	in	IN
cord-295807-68sukdb1	241	8	stroke	stroke	NN
cord-295807-68sukdb1	241	9	,	,	,
cord-295807-68sukdb1	241	10	by	by	IN
cord-295807-68sukdb1	241	11	inhibiting	inhibit	VBG
cord-295807-68sukdb1	241	12	caspase	caspase	NN
cord-295807-68sukdb1	241	13	and	and	CC
cord-295807-68sukdb1	241	14	other	other	JJ
cord-295807-68sukdb1	241	15	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	241	16	activities	activity	NNS
cord-295807-68sukdb1	241	17	[	[	-LRB-
cord-295807-68sukdb1	241	18	115	115	CD
cord-295807-68sukdb1	241	19	]	]	-RRB-
cord-295807-68sukdb1	241	20	,	,	,
cord-295807-68sukdb1	241	21	and	and	CC
cord-295807-68sukdb1	241	22	during	during	IN
cord-295807-68sukdb1	241	23	reperfusion	reperfusion	NN
cord-295807-68sukdb1	241	24	[	[	-LRB-
cord-295807-68sukdb1	241	25	116	116	CD
cord-295807-68sukdb1	241	26	]	]	-RRB-
cord-295807-68sukdb1	241	27	.	.	.
cord-295807-68sukdb1	242	1	CA	CA	NNP
cord-295807-68sukdb1	242	2	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	242	3	are	be	VBP
cord-295807-68sukdb1	242	4	used	use	VBN
cord-295807-68sukdb1	242	5	as	as	IN
cord-295807-68sukdb1	242	6	adjunct	adjunct	JJ
cord-295807-68sukdb1	242	7	therapies	therapy	NNS
cord-295807-68sukdb1	242	8	for	for	IN
cord-295807-68sukdb1	242	9	epilepsy	epilepsy	NN
cord-295807-68sukdb1	242	10	[	[	-LRB-
cord-295807-68sukdb1	242	11	117	117	CD
cord-295807-68sukdb1	242	12	]	]	-RRB-
cord-295807-68sukdb1	242	13	and	and	CC
cord-295807-68sukdb1	242	14	have	have	VBP
cord-295807-68sukdb1	242	15	potential	potential	JJ
cord-295807-68sukdb1	242	16	application	application	NN
cord-295807-68sukdb1	242	17	for	for	IN
cord-295807-68sukdb1	242	18	treatment	treatment	NN
cord-295807-68sukdb1	242	19	of	of	IN
cord-295807-68sukdb1	242	20	neuropathic	neuropathic	JJ
cord-295807-68sukdb1	242	21	pain	pain	NN
cord-295807-68sukdb1	242	22	[	[	-LRB-
cord-295807-68sukdb1	242	23	118	118	CD
cord-295807-68sukdb1	242	24	]	]	-RRB-
cord-295807-68sukdb1	242	25	,	,	,
cord-295807-68sukdb1	242	26	Alzheimer	Alzheimer	NNP
cord-295807-68sukdb1	242	27	's	's	POS
cord-295807-68sukdb1	242	28	disease	disease	NN
cord-295807-68sukdb1	242	29	[	[	-LRB-
cord-295807-68sukdb1	242	30	119	119	CD
cord-295807-68sukdb1	242	31	]	]	-RRB-
cord-295807-68sukdb1	242	32	,	,	,
cord-295807-68sukdb1	242	33	and	and	CC
cord-295807-68sukdb1	242	34	cognitive	cognitive	JJ
cord-295807-68sukdb1	242	35	disorders	disorder	NNS
cord-295807-68sukdb1	242	36	[	[	-LRB-
cord-295807-68sukdb1	242	37	120	120	CD
cord-295807-68sukdb1	242	38	]	]	-RRB-
cord-295807-68sukdb1	242	39	.	.	.
cord-295807-68sukdb1	243	1	However	however	RB
cord-295807-68sukdb1	243	2	,	,	,
cord-295807-68sukdb1	243	3	MAc	MAc	NNP
cord-295807-68sukdb1	243	4	is	be	VBZ
cord-295807-68sukdb1	243	5	a	a	DT
cord-295807-68sukdb1	243	6	side	side	JJ
cord-295807-68sukdb1	243	7	effect	effect	NN
cord-295807-68sukdb1	243	8	of	of	IN
cord-295807-68sukdb1	243	9	systemic	systemic	JJ
cord-295807-68sukdb1	243	10	CA	CA	NNP
cord-295807-68sukdb1	243	11	inhibition	inhibition	NN
cord-295807-68sukdb1	243	12	[	[	-LRB-
cord-295807-68sukdb1	243	13	121	121	CD
cord-295807-68sukdb1	243	14	]	]	-RRB-
cord-295807-68sukdb1	243	15	.	.	.
cord-295807-68sukdb1	244	1	Lowered	lower	VBN
cord-295807-68sukdb1	244	2	seizure	seizure	NN
cord-295807-68sukdb1	244	3	thresholds	threshold	NNS
cord-295807-68sukdb1	244	4	in	in	IN
cord-295807-68sukdb1	244	5	some	some	DT
cord-295807-68sukdb1	244	6	strains	strain	NNS
cord-295807-68sukdb1	244	7	of	of	IN
cord-295807-68sukdb1	244	8	ABT	abt	NN
cord-295807-68sukdb1	244	9	-	-	HYPH
cord-295807-68sukdb1	244	10	null	null	JJ
cord-295807-68sukdb1	244	11	mice	mouse	NNS
cord-295807-68sukdb1	244	12	suggest	suggest	VBP
cord-295807-68sukdb1	244	13	that	that	IN
cord-295807-68sukdb1	244	14	ABTs	ABTs	NNP
cord-295807-68sukdb1	244	15	may	may	MD
cord-295807-68sukdb1	244	16	be	be	VB
cord-295807-68sukdb1	244	17	potential	potential	JJ
cord-295807-68sukdb1	244	18	targets	target	NNS
cord-295807-68sukdb1	244	19	for	for	IN
cord-295807-68sukdb1	244	20	anticonvulsant	anticonvulsant	JJ
cord-295807-68sukdb1	244	21	therapy	therapy	NN
cord-295807-68sukdb1	244	22	.	.	.
cord-295807-68sukdb1	245	1	However	however	RB
cord-295807-68sukdb1	245	2	,	,	,
cord-295807-68sukdb1	245	3	the	the	DT
cord-295807-68sukdb1	245	4	need	need	NN
cord-295807-68sukdb1	245	5	for	for	IN
cord-295807-68sukdb1	245	6	caution	caution	NN
cord-295807-68sukdb1	245	7	is	be	VBZ
cord-295807-68sukdb1	245	8	shown	show	VBN
cord-295807-68sukdb1	245	9	by	by	IN
cord-295807-68sukdb1	245	10	the	the	DT
cord-295807-68sukdb1	245	11	observation	observation	NN
cord-295807-68sukdb1	245	12	that	that	IN
cord-295807-68sukdb1	245	13	,	,	,
cord-295807-68sukdb1	245	14	at	at	IN
cord-295807-68sukdb1	245	15	least	least	JJS
cord-295807-68sukdb1	245	16	in	in	IN
cord-295807-68sukdb1	245	17	the	the	DT
cord-295807-68sukdb1	245	18	case	case	NN
cord-295807-68sukdb1	245	19	of	of	IN
cord-295807-68sukdb1	245	20	NBCn2-null	nbcn2-null	JJ
cord-295807-68sukdb1	245	21	mice	mouse	NNS
cord-295807-68sukdb1	245	22	,	,	,
cord-295807-68sukdb1	245	23	a	a	DT
cord-295807-68sukdb1	245	24	reduced	reduce	VBN
cord-295807-68sukdb1	245	25	seizure	seizure	NN
cord-295807-68sukdb1	245	26	-	-	HYPH
cord-295807-68sukdb1	245	27	threshold	threshold	NN
cord-295807-68sukdb1	245	28	does	do	VBZ
cord-295807-68sukdb1	245	29	not	not	RB
cord-295807-68sukdb1	245	30	mean	mean	VB
cord-295807-68sukdb1	245	31	reduced	reduce	VBN
cord-295807-68sukdb1	245	32	neuronal	neuronal	JJ
cord-295807-68sukdb1	245	33	excitability	excitability	NN
cord-295807-68sukdb1	245	34	[	[	-LRB-
cord-295807-68sukdb1	245	35	122	122	CD
cord-295807-68sukdb1	245	36	]	]	-RRB-
cord-295807-68sukdb1	245	37	.	.	.
cord-295807-68sukdb1	246	1	The	the	DT
cord-295807-68sukdb1	246	2	role	role	NN
cord-295807-68sukdb1	246	3	of	of	IN
cord-295807-68sukdb1	246	4	ABTs	ABTs	NNP
cord-295807-68sukdb1	246	5	and	and	CC
cord-295807-68sukdb1	246	6	CAs	CAs	NNP
cord-295807-68sukdb1	246	7	in	in	IN
cord-295807-68sukdb1	246	8	CSF	CSF	NNP
cord-295807-68sukdb1	246	9	secretion	secretion	NN
cord-295807-68sukdb1	246	10	hints	hint	NNS
cord-295807-68sukdb1	246	11	at	at	IN
cord-295807-68sukdb1	246	12	the	the	DT
cord-295807-68sukdb1	246	13	potential	potential	NN
cord-295807-68sukdb1	246	14	for	for	IN
cord-295807-68sukdb1	246	15	targeting	target	VBG
cord-295807-68sukdb1	246	16	of	of	IN
cord-295807-68sukdb1	246	17	these	these	DT
cord-295807-68sukdb1	246	18	proteins	protein	NNS
cord-295807-68sukdb1	246	19	to	to	TO
cord-295807-68sukdb1	246	20	lower	lower	VB
cord-295807-68sukdb1	246	21	intracranial	intracranial	JJ
cord-295807-68sukdb1	246	22	pressure	pressure	NN
cord-295807-68sukdb1	246	23	in	in	IN
cord-295807-68sukdb1	246	24	idiopathic	idiopathic	JJ
cord-295807-68sukdb1	246	25	intracranial	intracranial	JJ
cord-295807-68sukdb1	246	26	hypertension	hypertension	NN
cord-295807-68sukdb1	246	27	(	(	-LRB-
cord-295807-68sukdb1	246	28	IIH	IIH	NNP
cord-295807-68sukdb1	246	29	)	)	-RRB-
cord-295807-68sukdb1	246	30	.	.	.
cord-295807-68sukdb1	247	1	The	the	DT
cord-295807-68sukdb1	247	2	use	use	NN
cord-295807-68sukdb1	247	3	of	of	IN
cord-295807-68sukdb1	247	4	CA	CA	NNP
cord-295807-68sukdb1	247	5	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	247	6	in	in	IN
cord-295807-68sukdb1	247	7	patients	patient	NNS
cord-295807-68sukdb1	247	8	with	with	IN
cord-295807-68sukdb1	247	9	IIH	IIH	NNP
cord-295807-68sukdb1	247	10	produces	produce	VBZ
cord-295807-68sukdb1	247	11	some	some	DT
cord-295807-68sukdb1	247	12	symptom	symptom	NN
cord-295807-68sukdb1	247	13	relief	relief	NN
cord-295807-68sukdb1	247	14	,	,	,
cord-295807-68sukdb1	247	15	but	but	CC
cord-295807-68sukdb1	247	16	the	the	DT
cord-295807-68sukdb1	247	17	mechanism	mechanism	NN
cord-295807-68sukdb1	247	18	of	of	IN
cord-295807-68sukdb1	247	19	action	action	NN
cord-295807-68sukdb1	247	20	is	be	VBZ
cord-295807-68sukdb1	247	21	uncertain	uncertain	JJ
cord-295807-68sukdb1	247	22	[	[	-LRB-
cord-295807-68sukdb1	247	23	123	123	CD
cord-295807-68sukdb1	247	24	]	]	-RRB-
cord-295807-68sukdb1	247	25	.	.	.
cord-295807-68sukdb1	248	1	Regarding	regard	VBG
cord-295807-68sukdb1	248	2	therapies	therapy	NNS
cord-295807-68sukdb1	248	3	for	for	IN
cord-295807-68sukdb1	248	4	neurodegenerative	neurodegenerative	JJ
cord-295807-68sukdb1	248	5	diseases	disease	NNS
cord-295807-68sukdb1	248	6	,	,	,
cord-295807-68sukdb1	248	7	histone	histone	NN
cord-295807-68sukdb1	248	8	deacetylase	deacetylase	NN
cord-295807-68sukdb1	248	9	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	248	10	have	have	VBP
cord-295807-68sukdb1	248	11	shown	show	VBN
cord-295807-68sukdb1	248	12	potential	potential	NN
cord-295807-68sukdb1	248	13	to	to	TO
cord-295807-68sukdb1	248	14	release	release	VB
cord-295807-68sukdb1	248	15	NHE6	NHE6	NNP
cord-295807-68sukdb1	248	16	from	from	IN
cord-295807-68sukdb1	248	17	its	-PRON-	PRP$
cord-295807-68sukdb1	248	18	epigenetic	epigenetic	JJ
cord-295807-68sukdb1	248	19	restraints	restraint	NNS
cord-295807-68sukdb1	248	20	to	to	TO
cord-295807-68sukdb1	248	21	restore	restore	VB
cord-295807-68sukdb1	248	22	amyloid	amyloid	NN
cord-295807-68sukdb1	248	23	protein	protein	NN
cord-295807-68sukdb1	248	24	processing	processing	NN
cord-295807-68sukdb1	248	25	in	in	IN
cord-295807-68sukdb1	248	26	ApoE4	ApoE4	NNP
cord-295807-68sukdb1	248	27	mice	mouse	NNS
cord-295807-68sukdb1	248	28	[	[	-LRB-
cord-295807-68sukdb1	248	29	113	113	CD
cord-295807-68sukdb1	248	30	]	]	-RRB-
cord-295807-68sukdb1	248	31	.	.	.
cord-295807-68sukdb1	249	1	Another	another	DT
cord-295807-68sukdb1	249	2	strategy	strategy	NN
cord-295807-68sukdb1	249	3	that	that	WDT
cord-295807-68sukdb1	249	4	has	have	VBZ
cord-295807-68sukdb1	249	5	been	be	VBN
cord-295807-68sukdb1	249	6	proposed	propose	VBN
cord-295807-68sukdb1	249	7	to	to	TO
cord-295807-68sukdb1	249	8	have	have	VB
cord-295807-68sukdb1	249	9	potential	potential	NN
cord-295807-68sukdb1	249	10	to	to	TO
cord-295807-68sukdb1	249	11	reverse	reverse	VB
cord-295807-68sukdb1	249	12	amyloid	amyloid	JJ
cord-295807-68sukdb1	249	13	deposition	deposition	NN
cord-295807-68sukdb1	249	14	in	in	IN
cord-295807-68sukdb1	249	15	Alzheimer	Alzheimer	NNP
cord-295807-68sukdb1	249	16	's	's	POS
cord-295807-68sukdb1	249	17	Disease	Disease	NNP
cord-295807-68sukdb1	249	18	is	be	VBZ
cord-295807-68sukdb1	249	19	the	the	DT
cord-295807-68sukdb1	249	20	raising	raising	NN
cord-295807-68sukdb1	249	21	of	of	IN
cord-295807-68sukdb1	249	22	brain	brain	NN
cord-295807-68sukdb1	249	23	pH	ph	NN
cord-295807-68sukdb1	249	24	[	[	-LRB-
cord-295807-68sukdb1	249	25	112	112	CD
cord-295807-68sukdb1	249	26	]	]	-RRB-
cord-295807-68sukdb1	249	27	.	.	.
cord-295807-68sukdb1	250	1	Therapies	therapy	NNS
cord-295807-68sukdb1	250	2	that	that	WDT
cord-295807-68sukdb1	250	3	target	target	VBP
cord-295807-68sukdb1	250	4	the	the	DT
cord-295807-68sukdb1	250	5	peripheral	peripheral	JJ
cord-295807-68sukdb1	250	6	nervous	nervous	JJ
cord-295807-68sukdb1	250	7	system	system	NN
cord-295807-68sukdb1	250	8	are	be	VBP
cord-295807-68sukdb1	250	9	discussed	discuss	VBN
cord-295807-68sukdb1	250	10	in	in	IN
cord-295807-68sukdb1	250	11	the	the	DT
cord-295807-68sukdb1	250	12	following	following	JJ
cord-295807-68sukdb1	250	13	section	section	NN
cord-295807-68sukdb1	250	14	.	.	.
cord-295807-68sukdb1	251	1	Sight	sight	NN
cord-295807-68sukdb1	251	2	.	.	.
cord-295807-68sukdb1	252	1	Most	Most	JJS
cord-295807-68sukdb1	252	2	ocular	ocular	JJ
cord-295807-68sukdb1	252	3	tissues	tissue	NNS
cord-295807-68sukdb1	252	4	express	express	VB
cord-295807-68sukdb1	252	5	one	one	CD
cord-295807-68sukdb1	252	6	or	or	CC
cord-295807-68sukdb1	252	7	more	more	JJR
cord-295807-68sukdb1	252	8	ABT	ABT	NNP
cord-295807-68sukdb1	252	9	or	or	CC
cord-295807-68sukdb1	252	10	CA	CA	NNP
cord-295807-68sukdb1	252	11	for	for	IN
cord-295807-68sukdb1	252	12	the	the	DT
cord-295807-68sukdb1	252	13	purpose	purpose	NN
cord-295807-68sukdb1	252	14	of	of	IN
cord-295807-68sukdb1	252	15	maintaining	maintain	VBG
cord-295807-68sukdb1	252	16	fluid	fluid	NN
cord-295807-68sukdb1	252	17	and	and	CC
cord-295807-68sukdb1	252	18	pH	ph	NN
cord-295807-68sukdb1	252	19	balance	balance	NN
cord-295807-68sukdb1	252	20	.	.	.
cord-295807-68sukdb1	253	1	Perhaps	perhaps	RB
cord-295807-68sukdb1	253	2	the	the	DT
cord-295807-68sukdb1	253	3	most	most	RBS
cord-295807-68sukdb1	253	4	therapeutically	therapeutically	RB
cord-295807-68sukdb1	253	5	tractable	tractable	JJ
cord-295807-68sukdb1	253	6	tissue	tissue	NN
cord-295807-68sukdb1	253	7	is	be	VBZ
cord-295807-68sukdb1	253	8	the	the	DT
cord-295807-68sukdb1	253	9	ciliary	ciliary	NN
cord-295807-68sukdb1	253	10	body	body	NN
cord-295807-68sukdb1	253	11	that	that	WDT
cord-295807-68sukdb1	253	12	employs	employ	VBZ
cord-295807-68sukdb1	253	13	CAII	CAII	NNP
cord-295807-68sukdb1	253	14	and	and	CC
cord-295807-68sukdb1	253	15	a	a	DT
cord-295807-68sukdb1	253	16	range	range	NN
cord-295807-68sukdb1	253	17	of	of	IN
cord-295807-68sukdb1	253	18	ABTs	abt	NNS
cord-295807-68sukdb1	253	19	to	to	TO
cord-295807-68sukdb1	253	20	secrete	secrete	VB
cord-295807-68sukdb1	254	1	HCO3	HCO3	NNP
cord-295807-68sukdb1	254	2	--containing	--containing	NN
cord-295807-68sukdb1	255	1	aqueous	aqueous	JJ
cord-295807-68sukdb1	255	2	humor	humor	NN
cord-295807-68sukdb1	255	3	into	into	IN
cord-295807-68sukdb1	255	4	the	the	DT
cord-295807-68sukdb1	255	5	anterior	anterior	NNP
cord-295807-68sukdb1	255	6	chamber	chamber	NN
cord-295807-68sukdb1	255	7	[	[	-LRB-
cord-295807-68sukdb1	255	8	124	124	CD
cord-295807-68sukdb1	255	9	,	,	,
cord-295807-68sukdb1	255	10	125	125	CD
cord-295807-68sukdb1	255	11	]	]	-RRB-
cord-295807-68sukdb1	256	1	(	(	-LRB-
cord-295807-68sukdb1	256	2	Figure	figure	NN
cord-295807-68sukdb1	256	3	5	5	CD
cord-295807-68sukdb1	256	4	)	)	-RRB-
cord-295807-68sukdb1	256	5	.	.	.
cord-295807-68sukdb1	257	1	This	this	DT
cord-295807-68sukdb1	257	2	fluid	fluid	JJ
cord-295807-68sukdb1	257	3	leaks	leak	VBZ
cord-295807-68sukdb1	257	4	into	into	IN
cord-295807-68sukdb1	257	5	the	the	DT
cord-295807-68sukdb1	257	6	corneal	corneal	JJ
cord-295807-68sukdb1	257	7	stroma	stroma	NN
cord-295807-68sukdb1	257	8	to	to	TO
cord-295807-68sukdb1	257	9	flush	flush	VB
cord-295807-68sukdb1	257	10	out	out	RP
cord-295807-68sukdb1	257	11	metabolic	metabolic	JJ
cord-295807-68sukdb1	257	12	wastes	waste	NNS
cord-295807-68sukdb1	257	13	and	and	CC
cord-295807-68sukdb1	257	14	is	be	VBZ
cord-295807-68sukdb1	257	15	returned	return	VBN
cord-295807-68sukdb1	257	16	to	to	IN
cord-295807-68sukdb1	257	17	the	the	DT
cord-295807-68sukdb1	257	18	anterior	anterior	NNP
cord-295807-68sukdb1	257	19	chamber	chamber	NN
cord-295807-68sukdb1	257	20	by	by	IN
cord-295807-68sukdb1	257	21	corneal	corneal	JJ
cord-295807-68sukdb1	257	22	endothelial	endothelial	JJ
cord-295807-68sukdb1	257	23	cells	cell	NNS
cord-295807-68sukdb1	257	24	which	which	WDT
cord-295807-68sukdb1	257	25	express	express	VBP
cord-295807-68sukdb1	257	26	a	a	DT
cord-295807-68sukdb1	257	27	similar	similar	JJ
cord-295807-68sukdb1	257	28	array	array	NN
cord-295807-68sukdb1	257	29	of	of	IN
cord-295807-68sukdb1	257	30	ABTs	ABTs	NNP
cord-295807-68sukdb1	257	31	including	include	VBG
cord-295807-68sukdb1	257	32	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	257	33	,	,	,
cord-295807-68sukdb1	257	34	MCT1	MCT1	NNP
cord-295807-68sukdb1	257	35	,	,	,
cord-295807-68sukdb1	257	36	and	and	CC
cord-295807-68sukdb1	257	37	the	the	DT
cord-295807-68sukdb1	257	38	H	h	NN
cord-295807-68sukdb1	257	39	+	+	CC
cord-295807-68sukdb1	257	40	channel	channel	NN
cord-295807-68sukdb1	258	1	SLC4A11	SLC4A11	NNP
cord-295807-68sukdb1	258	2	[	[	-LRB-
cord-295807-68sukdb1	258	3	126	126	CD
cord-295807-68sukdb1	258	4	,	,	,
cord-295807-68sukdb1	258	5	127	127	CD
cord-295807-68sukdb1	258	6	]	]	-RRB-
cord-295807-68sukdb1	258	7	.	.	.
cord-295807-68sukdb1	259	1	Finally	finally	RB
cord-295807-68sukdb1	259	2	,	,	,
cord-295807-68sukdb1	259	3	the	the	DT
cord-295807-68sukdb1	259	4	fluid	fluid	NN
cord-295807-68sukdb1	259	5	is	be	VBZ
cord-295807-68sukdb1	259	6	drained	drain	VBN
cord-295807-68sukdb1	259	7	from	from	IN
cord-295807-68sukdb1	259	8	the	the	DT
cord-295807-68sukdb1	259	9	anterior	anterior	NNP
cord-295807-68sukdb1	259	10	chamber	chamber	NNP
cord-295807-68sukdb1	259	11	via	via	IN
cord-295807-68sukdb1	259	12	the	the	DT
cord-295807-68sukdb1	259	13	trabecular	trabecular	JJ
cord-295807-68sukdb1	259	14	meshwork	meshwork	NN
cord-295807-68sukdb1	259	15	.	.	.
cord-295807-68sukdb1	260	1	Individuals	individual	NNS
cord-295807-68sukdb1	260	2	with	with	IN
cord-295807-68sukdb1	260	3	mutations	mutation	NNS
cord-295807-68sukdb1	260	4	in	in	IN
cord-295807-68sukdb1	260	5	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	260	6	have	have	VBP
cord-295807-68sukdb1	260	7	band	band	NN
cord-295807-68sukdb1	260	8	keratopathy	keratopathy	NNP
cord-295807-68sukdb1	260	9	,	,	,
cord-295807-68sukdb1	260	10	glaucoma	glaucoma	NN
cord-295807-68sukdb1	260	11	,	,	,
cord-295807-68sukdb1	260	12	cataracts	cataract	NNS
cord-295807-68sukdb1	260	13	,	,	,
cord-295807-68sukdb1	260	14	and	and	CC
cord-295807-68sukdb1	260	15	corneal	corneal	JJ
cord-295807-68sukdb1	260	16	edema	edema	NN
cord-295807-68sukdb1	260	17	linked	link	VBN
cord-295807-68sukdb1	260	18	to	to	IN
cord-295807-68sukdb1	260	19	fluid	fluid	NN
cord-295807-68sukdb1	260	20	/	/	SYM
cord-295807-68sukdb1	260	21	pH	ph	NN
cord-295807-68sukdb1	260	22	imbalance	imbalance	NN
cord-295807-68sukdb1	260	23	in	in	IN
cord-295807-68sukdb1	260	24	the	the	DT
cord-295807-68sukdb1	260	25	cornea	cornea	NN
cord-295807-68sukdb1	260	26	,	,	,
cord-295807-68sukdb1	260	27	lens	lens	NN
cord-295807-68sukdb1	260	28	,	,	,
cord-295807-68sukdb1	260	29	and	and	CC
cord-295807-68sukdb1	260	30	elsewhere	elsewhere	RB
cord-295807-68sukdb1	260	31	[	[	-LRB-
cord-295807-68sukdb1	260	32	128	128	CD
cord-295807-68sukdb1	260	33	]	]	-RRB-
cord-295807-68sukdb1	260	34	.	.	.
cord-295807-68sukdb1	261	1	ABTs	ABTs	NNP
cord-295807-68sukdb1	261	2	and	and	CC
cord-295807-68sukdb1	261	3	HCO3are	HCO3are	NNP
cord-295807-68sukdb1	261	4	also	also	RB
cord-295807-68sukdb1	261	5	important	important	JJ
cord-295807-68sukdb1	261	6	for	for	IN
cord-295807-68sukdb1	261	7	retinal	retinal	JJ
cord-295807-68sukdb1	261	8	function	function	NN
cord-295807-68sukdb1	261	9	[	[	-LRB-
cord-295807-68sukdb1	261	10	129	129	CD
cord-295807-68sukdb1	261	11	]	]	-RRB-
cord-295807-68sukdb1	261	12	[	[	-LRB-
cord-295807-68sukdb1	261	13	130	130	CD
cord-295807-68sukdb1	261	14	]	]	-RRB-
cord-295807-68sukdb1	261	15	[	[	-LRB-
cord-295807-68sukdb1	261	16	131	131	CD
cord-295807-68sukdb1	261	17	]	]	-RRB-
cord-295807-68sukdb1	261	18	,	,	,
cord-295807-68sukdb1	261	19	as	as	IN
cord-295807-68sukdb1	261	20	suggested	suggest	VBN
cord-295807-68sukdb1	261	21	by	by	IN
cord-295807-68sukdb1	261	22	the	the	DT
cord-295807-68sukdb1	261	23	link	link	NN
cord-295807-68sukdb1	261	24	between	between	IN
cord-295807-68sukdb1	261	25	NBCn1	NBCn1	NNP
cord-295807-68sukdb1	261	26	mutation	mutation	NN
cord-295807-68sukdb1	261	27	and	and	CC
cord-295807-68sukdb1	261	28	progressive	progressive	JJ
cord-295807-68sukdb1	261	29	rod	rod	NN
cord-295807-68sukdb1	261	30	-	-	HYPH
cord-295807-68sukdb1	261	31	cone	cone	NN
cord-295807-68sukdb1	261	32	dystrophy	dystrophy	NN
cord-295807-68sukdb1	261	33	[	[	-LRB-
cord-295807-68sukdb1	261	34	132	132	CD
cord-295807-68sukdb1	261	35	]	]	-RRB-
cord-295807-68sukdb1	261	36	,	,	,
cord-295807-68sukdb1	261	37	or	or	CC
cord-295807-68sukdb1	261	38	retinal	retinal	JJ
cord-295807-68sukdb1	261	39	degeneration	degeneration	NN
cord-295807-68sukdb1	261	40	in	in	IN
cord-295807-68sukdb1	261	41	mice	mouse	NNS
cord-295807-68sukdb1	261	42	with	with	IN
cord-295807-68sukdb1	261	43	defective	defective	JJ
cord-295807-68sukdb1	261	44	expression	expression	NN
cord-295807-68sukdb1	261	45	of	of	IN
cord-295807-68sukdb1	261	46	NBCe2	nbce2	NN
cord-295807-68sukdb1	261	47	and	and	CC
cord-295807-68sukdb1	261	48	MCTs	MCTs	NNPS
cord-295807-68sukdb1	261	49	[	[	-LRB-
cord-295807-68sukdb1	261	50	133	133	CD
cord-295807-68sukdb1	261	51	,	,	,
cord-295807-68sukdb1	261	52	134	134	CD
cord-295807-68sukdb1	261	53	]	]	-RRB-
cord-295807-68sukdb1	261	54	.	.	.
cord-295807-68sukdb1	262	1	Hearing	hear	VBG
cord-295807-68sukdb1	262	2	loss	loss	NN
cord-295807-68sukdb1	262	3	is	be	VBZ
cord-295807-68sukdb1	262	4	a	a	DT
cord-295807-68sukdb1	262	5	symptom	symptom	NN
cord-295807-68sukdb1	262	6	of	of	IN
cord-295807-68sukdb1	262	7	several	several	JJ
cord-295807-68sukdb1	262	8	systemic	systemic	JJ
cord-295807-68sukdb1	262	9	diseases	disease	NNS
cord-295807-68sukdb1	262	10	linked	link	VBN
cord-295807-68sukdb1	262	11	to	to	IN
cord-295807-68sukdb1	262	12	defects	defect	NNS
cord-295807-68sukdb1	262	13	in	in	IN
cord-295807-68sukdb1	262	14	ABTs	ABTs	NNP
cord-295807-68sukdb1	262	15	,	,	,
cord-295807-68sukdb1	262	16	including	include	VBG
cord-295807-68sukdb1	262	17	pendrin	pendrin	NN
cord-295807-68sukdb1	262	18	(	(	-LRB-
cord-295807-68sukdb1	262	19	Pendred	Pendred	NNP
cord-295807-68sukdb1	262	20	syndrome	syndrome	NN
cord-295807-68sukdb1	262	21	[	[	-LRB-
cord-295807-68sukdb1	262	22	135	135	CD
cord-295807-68sukdb1	262	23	]	]	-RRB-
cord-295807-68sukdb1	262	24	)	)	-RRB-
cord-295807-68sukdb1	262	25	,	,	,
cord-295807-68sukdb1	262	26	the	the	DT
cord-295807-68sukdb1	262	27	H	h	NN
cord-295807-68sukdb1	262	28	+	+	CC
cord-295807-68sukdb1	262	29	/K	/K	.
cord-295807-68sukdb1	263	1	+	+	CC
cord-295807-68sukdb1	264	1	-ATPase	-ATPase	NNP
cord-295807-68sukdb1	265	1	(	(	-LRB-
cord-295807-68sukdb1	265	2	distal	distal	JJ
cord-295807-68sukdb1	265	3	renal	renal	JJ
cord-295807-68sukdb1	265	4	tubular	tubular	JJ
cord-295807-68sukdb1	265	5	acidosis	acidosis	NN
cord-295807-68sukdb1	265	6	[	[	-LRB-
cord-295807-68sukdb1	265	7	136	136	CD
cord-295807-68sukdb1	265	8	]	]	-RRB-
cord-295807-68sukdb1	265	9	)	)	-RRB-
cord-295807-68sukdb1	265	10	,	,	,
cord-295807-68sukdb1	265	11	and	and	CC
cord-295807-68sukdb1	265	12	SLC4A11	slc4a11	CD
cord-295807-68sukdb1	266	1	(	(	-LRB-
cord-295807-68sukdb1	266	2	Harboyan	Harboyan	NNP
cord-295807-68sukdb1	266	3	syndrome	syndrome	NN
cord-295807-68sukdb1	266	4	[	[	-LRB-
cord-295807-68sukdb1	266	5	137	137	CD
cord-295807-68sukdb1	266	6	]	]	-RRB-
cord-295807-68sukdb1	266	7	)	)	-RRB-
cord-295807-68sukdb1	266	8	.	.	.
cord-295807-68sukdb1	267	1	All	all	DT
cord-295807-68sukdb1	267	2	of	of	IN
cord-295807-68sukdb1	267	3	these	these	DT
cord-295807-68sukdb1	267	4	ABTs	abt	NNS
cord-295807-68sukdb1	267	5	are	be	VBP
cord-295807-68sukdb1	267	6	expressed	express	VBN
cord-295807-68sukdb1	267	7	in	in	IN
cord-295807-68sukdb1	267	8	the	the	DT
cord-295807-68sukdb1	267	9	inner	inner	JJ
cord-295807-68sukdb1	267	10	ear	ear	NN
cord-295807-68sukdb1	267	11	where	where	WRB
cord-295807-68sukdb1	267	12	they	-PRON-	PRP
cord-295807-68sukdb1	267	13	help	help	VBP
cord-295807-68sukdb1	267	14	to	to	TO
cord-295807-68sukdb1	267	15	maintain	maintain	VB
cord-295807-68sukdb1	267	16	inner	inner	JJ
cord-295807-68sukdb1	267	17	ear	ear	NN
cord-295807-68sukdb1	267	18	fluid	fluid	NN
cord-295807-68sukdb1	267	19	pH	ph	NN
cord-295807-68sukdb1	267	20	and	and	CC
cord-295807-68sukdb1	267	21	endocochlear	endocochlear	JJ
cord-295807-68sukdb1	267	22	potential	potential	NN
cord-295807-68sukdb1	267	23	[	[	-LRB-
cord-295807-68sukdb1	267	24	138	138	CD
cord-295807-68sukdb1	267	25	]	]	-RRB-
cord-295807-68sukdb1	267	26	.	.	.
cord-295807-68sukdb1	268	1	Although	although	IN
cord-295807-68sukdb1	268	2	a	a	DT
cord-295807-68sukdb1	268	3	human	human	NN
cord-295807-68sukdb1	268	4	correlate	correlate	NN
cord-295807-68sukdb1	268	5	has	have	VBZ
cord-295807-68sukdb1	268	6	not	not	RB
cord-295807-68sukdb1	268	7	yet	yet	RB
cord-295807-68sukdb1	268	8	been	be	VBN
cord-295807-68sukdb1	268	9	reported	report	VBN
cord-295807-68sukdb1	268	10	,	,	,
cord-295807-68sukdb1	268	11	progressive	progressive	JJ
cord-295807-68sukdb1	268	12	hearing	hearing	NN
cord-295807-68sukdb1	268	13	loss	loss	NN
cord-295807-68sukdb1	268	14	is	be	VBZ
cord-295807-68sukdb1	268	15	also	also	RB
cord-295807-68sukdb1	268	16	a	a	DT
cord-295807-68sukdb1	268	17	feature	feature	NN
cord-295807-68sukdb1	268	18	of	of	IN
cord-295807-68sukdb1	268	19	NBCn2null	NBCn2null	NNP
cord-295807-68sukdb1	268	20	mice	mouse	NNS
cord-295807-68sukdb1	268	21	[	[	-LRB-
cord-295807-68sukdb1	268	22	139	139	CD
cord-295807-68sukdb1	268	23	]	]	-RRB-
cord-295807-68sukdb1	268	24	.	.	.
cord-295807-68sukdb1	269	1	Disruption	disruption	NN
cord-295807-68sukdb1	269	2	of	of	IN
cord-295807-68sukdb1	269	3	the	the	DT
cord-295807-68sukdb1	269	4	H	h	NN
cord-295807-68sukdb1	269	5	+	+	CC
cord-295807-68sukdb1	270	1	-channel	-channel	NFP
cord-295807-68sukdb1	270	2	OTOP1	otop1	XX
cord-295807-68sukdb1	271	1	and	and	CC
cord-295807-68sukdb1	271	2	the	the	DT
cord-295807-68sukdb1	271	3	anion	anion	NN
cord-295807-68sukdb1	271	4	exchanger	exchanger	NN
cord-295807-68sukdb1	271	5	pendrin	pendrin	NNP
cord-295807-68sukdb1	271	6	in	in	IN
cord-295807-68sukdb1	271	7	mice	mouse	NNS
cord-295807-68sukdb1	271	8	is	be	VBZ
cord-295807-68sukdb1	271	9	associated	associate	VBN
cord-295807-68sukdb1	271	10	with	with	IN
cord-295807-68sukdb1	271	11	malformation	malformation	NN
cord-295807-68sukdb1	271	12	of	of	IN
cord-295807-68sukdb1	271	13	the	the	DT
cord-295807-68sukdb1	271	14	CaCO3	CaCO3	NNP
cord-295807-68sukdb1	271	15	crystals	crystal	NNS
cord-295807-68sukdb1	271	16	(	(	-LRB-
cord-295807-68sukdb1	271	17	otoconia	otoconia	NNP
cord-295807-68sukdb1	271	18	)	)	-RRB-
cord-295807-68sukdb1	271	19	that	that	WDT
cord-295807-68sukdb1	271	20	are	be	VBP
cord-295807-68sukdb1	271	21	essential	essential	JJ
cord-295807-68sukdb1	271	22	for	for	IN
cord-295807-68sukdb1	271	23	maintenance	maintenance	NN
cord-295807-68sukdb1	271	24	of	of	IN
cord-295807-68sukdb1	271	25	balance	balance	NN
cord-295807-68sukdb1	271	26	[	[	-LRB-
cord-295807-68sukdb1	271	27	140	140	CD
cord-295807-68sukdb1	271	28	,	,	,
cord-295807-68sukdb1	271	29	141	141	CD
cord-295807-68sukdb1	271	30	]	]	-RRB-
cord-295807-68sukdb1	271	31	.	.	.
cord-295807-68sukdb1	272	1	Taste	taste	NN
cord-295807-68sukdb1	272	2	.	.	.
cord-295807-68sukdb1	273	1	In	in	IN
cord-295807-68sukdb1	273	2	addition	addition	NN
cord-295807-68sukdb1	273	3	to	to	IN
cord-295807-68sukdb1	273	4	its	-PRON-	PRP$
cord-295807-68sukdb1	273	5	role	role	NN
cord-295807-68sukdb1	273	6	in	in	IN
cord-295807-68sukdb1	273	7	the	the	DT
cord-295807-68sukdb1	273	8	inner	inner	JJ
cord-295807-68sukdb1	273	9	ear	ear	NN
cord-295807-68sukdb1	273	10	,	,	,
cord-295807-68sukdb1	273	11	OTOP1	OTOP1	NNP
cord-295807-68sukdb1	273	12	is	be	VBZ
cord-295807-68sukdb1	273	13	required	require	VBN
cord-295807-68sukdb1	273	14	for	for	IN
cord-295807-68sukdb1	273	15	sour	sour	JJ
cord-295807-68sukdb1	273	16	taste	taste	NN
cord-295807-68sukdb1	273	17	sensation	sensation	NN
cord-295807-68sukdb1	273	18	[	[	-LRB-
cord-295807-68sukdb1	273	19	37	37	CD
cord-295807-68sukdb1	273	20	]	]	-RRB-
cord-295807-68sukdb1	273	21	.	.	.
cord-295807-68sukdb1	274	1	Pain	pain	NN
cord-295807-68sukdb1	274	2	sensation	sensation	NN
cord-295807-68sukdb1	274	3	.	.	.
cord-295807-68sukdb1	275	1	It	-PRON-	PRP
cord-295807-68sukdb1	275	2	is	be	VBZ
cord-295807-68sukdb1	275	3	generally	generally	RB
cord-295807-68sukdb1	275	4	recommended	recommend	VBN
cord-295807-68sukdb1	275	5	to	to	TO
cord-295807-68sukdb1	275	6	keep	keep	VB
cord-295807-68sukdb1	275	7	the	the	DT
cord-295807-68sukdb1	275	8	pH	ph	NN
cord-295807-68sukdb1	275	9	of	of	IN
cord-295807-68sukdb1	275	10	injected	inject	VBN
cord-295807-68sukdb1	275	11	formulation	formulation	NN
cord-295807-68sukdb1	275	12	close	close	RB
cord-295807-68sukdb1	275	13	to	to	IN
cord-295807-68sukdb1	275	14	physiological	physiological	JJ
cord-295807-68sukdb1	275	15	pH	ph	NN
cord-295807-68sukdb1	275	16	to	to	TO
cord-295807-68sukdb1	275	17	avoid	avoid	VB
cord-295807-68sukdb1	275	18	injection	injection	NN
cord-295807-68sukdb1	275	19	-	-	HYPH
cord-295807-68sukdb1	275	20	site	site	NN
cord-295807-68sukdb1	275	21	pain	pain	NN
cord-295807-68sukdb1	275	22	,	,	,
cord-295807-68sukdb1	275	23	with	with	IN
cord-295807-68sukdb1	275	24	the	the	DT
cord-295807-68sukdb1	275	25	added	add	VBN
cord-295807-68sukdb1	275	26	note	note	NN
cord-295807-68sukdb1	275	27	that	that	IN
cord-295807-68sukdb1	275	28	the	the	DT
cord-295807-68sukdb1	275	29	inclusion	inclusion	NN
cord-295807-68sukdb1	275	30	of	of	IN
cord-295807-68sukdb1	275	31	certain	certain	JJ
cord-295807-68sukdb1	275	32	buffers	buffer	NNS
cord-295807-68sukdb1	275	33	may	may	MD
cord-295807-68sukdb1	275	34	increase	increase	VB
cord-295807-68sukdb1	275	35	pain	pain	NN
cord-295807-68sukdb1	275	36	(	(	-LRB-
cord-295807-68sukdb1	275	37	hence	hence	RB
cord-295807-68sukdb1	275	38	new	new	JJ
cord-295807-68sukdb1	275	39	citrate	citrate	NN
cord-295807-68sukdb1	275	40	-	-	HYPH
cord-295807-68sukdb1	275	41	free	free	JJ
cord-295807-68sukdb1	275	42	formulations	formulation	NNS
cord-295807-68sukdb1	275	43	of	of	IN
cord-295807-68sukdb1	275	44	adalimubab	adalimubab	NNP
cord-295807-68sukdb1	276	1	aka	aka	RB
cord-295807-68sukdb1	276	2	HUMIRA	HUMIRA	NNP
cord-295807-68sukdb1	276	3	®	®	POS
cord-295807-68sukdb1	276	4	)	)	-RRB-
cord-295807-68sukdb1	276	5	[	[	-LRB-
cord-295807-68sukdb1	276	6	142	142	CD
cord-295807-68sukdb1	276	7	]	]	-RRB-
cord-295807-68sukdb1	276	8	.	.	.
cord-295807-68sukdb1	277	1	Low	low	JJ
cord-295807-68sukdb1	277	2	pHe	phe	NN
cord-295807-68sukdb1	277	3	exacerbates	exacerbate	VBZ
cord-295807-68sukdb1	277	4	sensation	sensation	NN
cord-295807-68sukdb1	277	5	of	of	IN
cord-295807-68sukdb1	277	6	pain	pain	NN
cord-295807-68sukdb1	277	7	due	due	IN
cord-295807-68sukdb1	277	8	to	to	IN
cord-295807-68sukdb1	277	9	its	-PRON-	PRP$
cord-295807-68sukdb1	277	10	effects	effect	NNS
cord-295807-68sukdb1	277	11	on	on	IN
cord-295807-68sukdb1	277	12	TRPV1	TRPV1	NNP
cord-295807-68sukdb1	277	13	channel	channel	NN
cord-295807-68sukdb1	277	14	activation	activation	NN
cord-295807-68sukdb1	277	15	in	in	IN
cord-295807-68sukdb1	277	16	nociceptive	nociceptive	JJ
cord-295807-68sukdb1	277	17	neurons	neuron	NNS
cord-295807-68sukdb1	277	18	.	.	.
cord-295807-68sukdb1	278	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	278	2	,	,	,
cord-295807-68sukdb1	278	3	activation	activation	NN
cord-295807-68sukdb1	278	4	of	of	IN
cord-295807-68sukdb1	278	5	these	these	DT
cord-295807-68sukdb1	278	6	channels	channel	NNS
cord-295807-68sukdb1	278	7	under	under	IN
cord-295807-68sukdb1	278	8	acidotic	acidotic	JJ
cord-295807-68sukdb1	278	9	conditions	condition	NNS
cord-295807-68sukdb1	278	10	is	be	VBZ
cord-295807-68sukdb1	278	11	associated	associate	VBN
cord-295807-68sukdb1	278	12	with	with	IN
cord-295807-68sukdb1	278	13	a	a	DT
cord-295807-68sukdb1	278	14	drop	drop	NN
cord-295807-68sukdb1	278	15	in	in	IN
cord-295807-68sukdb1	278	16	neuronal	neuronal	JJ
cord-295807-68sukdb1	278	17	pHi	pHi	NNS
cord-295807-68sukdb1	278	18	that	that	WDT
cord-295807-68sukdb1	278	19	is	be	VBZ
cord-295807-68sukdb1	278	20	mediated	mediate	VBN
cord-295807-68sukdb1	278	21	in	in	IN
cord-295807-68sukdb1	278	22	part	part	NN
cord-295807-68sukdb1	278	23	by	by	IN
cord-295807-68sukdb1	278	24	a	a	DT
cord-295807-68sukdb1	278	25	TRPV1-mediated	TRPV1-mediated	NNP
cord-295807-68sukdb1	278	26	H	H	NNP
cord-295807-68sukdb1	278	27	+	+	CC
cord-295807-68sukdb1	278	28	 	 	_SP
cord-295807-68sukdb1	278	29	Sight	Sight	NNP
cord-295807-68sukdb1	278	30	.	.	.
cord-295807-68sukdb1	279	1	CA	CA	NNP
cord-295807-68sukdb1	279	2	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	279	3	applied	apply	VBD
cord-295807-68sukdb1	279	4	as	as	IN
cord-295807-68sukdb1	279	5	eye	eye	NN
cord-295807-68sukdb1	279	6	drops	drop	NNS
cord-295807-68sukdb1	279	7	have	have	VBP
cord-295807-68sukdb1	279	8	long	long	RB
cord-295807-68sukdb1	279	9	been	be	VBN
cord-295807-68sukdb1	279	10	used	use	VBN
cord-295807-68sukdb1	279	11	to	to	TO
cord-295807-68sukdb1	279	12	treat	treat	VB
cord-295807-68sukdb1	279	13	glaucoma	glaucoma	NN
cord-295807-68sukdb1	279	14	by	by	IN
cord-295807-68sukdb1	279	15	virtue	virtue	NN
cord-295807-68sukdb1	279	16	of	of	IN
cord-295807-68sukdb1	279	17	their	-PRON-	PRP$
cord-295807-68sukdb1	279	18	ability	ability	NN
cord-295807-68sukdb1	279	19	to	to	TO
cord-295807-68sukdb1	279	20	reduce	reduce	VB
cord-295807-68sukdb1	279	21	the	the	DT
cord-295807-68sukdb1	279	22	production	production	NN
cord-295807-68sukdb1	279	23	of	of	IN
cord-295807-68sukdb1	279	24	aqueous	aqueous	JJ
cord-295807-68sukdb1	279	25	humor	humor	NN
cord-295807-68sukdb1	279	26	,	,	,
cord-295807-68sukdb1	279	27	although	although	IN
cord-295807-68sukdb1	279	28	even	even	RB
cord-295807-68sukdb1	279	29	their	-PRON-	PRP$
cord-295807-68sukdb1	279	30	localized	localize	VBN
cord-295807-68sukdb1	279	31	ophthalmic	ophthalmic	JJ
cord-295807-68sukdb1	279	32	use	use	NN
cord-295807-68sukdb1	279	33	has	have	VBZ
cord-295807-68sukdb1	279	34	been	be	VBN
cord-295807-68sukdb1	279	35	documented	document	VBN
cord-295807-68sukdb1	279	36	to	to	TO
cord-295807-68sukdb1	279	37	lead	lead	VB
cord-295807-68sukdb1	279	38	to	to	IN
cord-295807-68sukdb1	279	39	the	the	DT
cord-295807-68sukdb1	279	40	side	side	NN
cord-295807-68sukdb1	279	41	-	-	HYPH
cord-295807-68sukdb1	279	42	effect	effect	NN
cord-295807-68sukdb1	279	43	of	of	IN
cord-295807-68sukdb1	279	44	systemic	systemic	JJ
cord-295807-68sukdb1	279	45	MAc	mac	NN
cord-295807-68sukdb1	279	46	in	in	IN
cord-295807-68sukdb1	279	47	some	some	DT
cord-295807-68sukdb1	279	48	prone	prone	JJ
cord-295807-68sukdb1	279	49	individuals	individual	NNS
cord-295807-68sukdb1	279	50	[	[	-LRB-
cord-295807-68sukdb1	279	51	144	144	CD
cord-295807-68sukdb1	279	52	,	,	,
cord-295807-68sukdb1	279	53	145	145	CD
cord-295807-68sukdb1	279	54	]	]	-RRB-
cord-295807-68sukdb1	279	55	.	.	.
cord-295807-68sukdb1	280	1	Corneal	corneal	JJ
cord-295807-68sukdb1	280	2	edema	edema	NN
cord-295807-68sukdb1	280	3	that	that	IN
cord-295807-68sukdb1	280	4	results	result	VBZ
cord-295807-68sukdb1	280	5	from	from	IN
cord-295807-68sukdb1	280	6	the	the	DT
cord-295807-68sukdb1	280	7	expression	expression	NN
cord-295807-68sukdb1	280	8	of	of	IN
cord-295807-68sukdb1	280	9	mutant	mutant	JJ
cord-295807-68sukdb1	280	10	misfolded	misfolde	VBN
cord-295807-68sukdb1	280	11	SLC4A11	slc4a11	CD
cord-295807-68sukdb1	280	12	may	may	MD
cord-295807-68sukdb1	280	13	be	be	VB
cord-295807-68sukdb1	280	14	amenable	amenable	JJ
cord-295807-68sukdb1	280	15	to	to	IN
cord-295807-68sukdb1	280	16	correction	correction	NN
cord-295807-68sukdb1	280	17	by	by	IN
cord-295807-68sukdb1	280	18	small	small	JJ
cord-295807-68sukdb1	280	19	molecule	molecule	NN
cord-295807-68sukdb1	280	20	folding	folding	NN
cord-295807-68sukdb1	280	21	chaperones	chaperone	NNS
cord-295807-68sukdb1	280	22	[	[	-LRB-
cord-295807-68sukdb1	280	23	146	146	CD
cord-295807-68sukdb1	280	24	]	]	-RRB-
cord-295807-68sukdb1	280	25	.	.	.
cord-295807-68sukdb1	281	1	NHE1	NHE1	NNP
cord-295807-68sukdb1	281	2	blockers	blocker	NNS
cord-295807-68sukdb1	281	3	are	be	VBP
cord-295807-68sukdb1	281	4	cytoprotective	cytoprotective	JJ
cord-295807-68sukdb1	281	5	in	in	IN
cord-295807-68sukdb1	281	6	a	a	DT
cord-295807-68sukdb1	281	7	rat	rat	NN
cord-295807-68sukdb1	281	8	model	model	NN
cord-295807-68sukdb1	281	9	of	of	IN
cord-295807-68sukdb1	281	10	diabetic	diabetic	JJ
cord-295807-68sukdb1	281	11	cataract	cataract	NN
cord-295807-68sukdb1	281	12	formation	formation	NN
cord-295807-68sukdb1	281	13	and	and	CC
cord-295807-68sukdb1	281	14	retinopathy	retinopathy	NN
cord-295807-68sukdb1	281	15	[	[	-LRB-
cord-295807-68sukdb1	281	16	147	147	CD
cord-295807-68sukdb1	281	17	]	]	-RRB-
cord-295807-68sukdb1	281	18	.	.	.
cord-295807-68sukdb1	282	1	Hypercapnia	Hypercapnia	NNP
cord-295807-68sukdb1	282	2	is	be	VBZ
cord-295807-68sukdb1	282	3	protective	protective	JJ
cord-295807-68sukdb1	282	4	against	against	IN
cord-295807-68sukdb1	282	5	ischemia	ischemia	NN
cord-295807-68sukdb1	282	6	-	-	HYPH
cord-295807-68sukdb1	282	7	reperfusion	reperfusion	NN
cord-295807-68sukdb1	282	8	injury	injury	NN
cord-295807-68sukdb1	282	9	in	in	IN
cord-295807-68sukdb1	282	10	the	the	DT
cord-295807-68sukdb1	282	11	retina	retina	NN
cord-295807-68sukdb1	282	12	[	[	-LRB-
cord-295807-68sukdb1	282	13	148	148	CD
cord-295807-68sukdb1	282	14	]	]	-RRB-
cord-295807-68sukdb1	282	15	,	,	,
cord-295807-68sukdb1	282	16	as	as	IN
cord-295807-68sukdb1	282	17	it	-PRON-	PRP
cord-295807-68sukdb1	282	18	is	be	VBZ
cord-295807-68sukdb1	282	19	elsewhere	elsewhere	RB
cord-295807-68sukdb1	282	20	in	in	IN
cord-295807-68sukdb1	282	21	the	the	DT
cord-295807-68sukdb1	282	22	central	central	JJ
cord-295807-68sukdb1	282	23	nervous	nervous	JJ
cord-295807-68sukdb1	282	24	system	system	NN
cord-295807-68sukdb1	282	25	(	(	-LRB-
cord-295807-68sukdb1	282	26	see	see	VB
cord-295807-68sukdb1	282	27	section	section	NN
cord-295807-68sukdb1	282	28	4.1	4.1	CD
cord-295807-68sukdb1	282	29	)	)	-RRB-
cord-295807-68sukdb1	282	30	.	.	.
cord-295807-68sukdb1	283	1	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	283	2	solution	solution	NN
cord-295807-68sukdb1	283	3	is	be	VBZ
cord-295807-68sukdb1	283	4	useful	useful	JJ
cord-295807-68sukdb1	283	5	for	for	IN
cord-295807-68sukdb1	283	6	softening	soften	VBG
cord-295807-68sukdb1	283	7	and	and	CC
cord-295807-68sukdb1	283	8	dispersing	disperse	VBG
cord-295807-68sukdb1	283	9	hardened	harden	VBN
cord-295807-68sukdb1	283	10	ear	ear	NN
cord-295807-68sukdb1	283	11	wax	wax	NN
cord-295807-68sukdb1	283	12	[	[	-LRB-
cord-295807-68sukdb1	283	13	149	149	CD
cord-295807-68sukdb1	283	14	]	]	-RRB-
cord-295807-68sukdb1	283	15	.	.	.
cord-295807-68sukdb1	284	1	However	however	RB
cord-295807-68sukdb1	284	2	,	,	,
cord-295807-68sukdb1	284	3	we	-PRON-	PRP
cord-295807-68sukdb1	284	4	are	be	VBP
cord-295807-68sukdb1	284	5	unaware	unaware	JJ
cord-295807-68sukdb1	284	6	of	of	IN
cord-295807-68sukdb1	284	7	any	any	DT
cord-295807-68sukdb1	284	8	therapies	therapy	NNS
cord-295807-68sukdb1	284	9	specifically	specifically	RB
cord-295807-68sukdb1	284	10	targeted	target	VBN
cord-295807-68sukdb1	284	11	to	to	IN
cord-295807-68sukdb1	284	12	restoring	restore	VBG
cord-295807-68sukdb1	284	13	the	the	DT
cord-295807-68sukdb1	284	14	acid	acid	NN
cord-295807-68sukdb1	284	15	-	-	HYPH
cord-295807-68sukdb1	284	16	base	base	NN
cord-295807-68sukdb1	284	17	chemistry	chemistry	NN
cord-295807-68sukdb1	284	18	necessary	necessary	JJ
cord-295807-68sukdb1	284	19	for	for	IN
cord-295807-68sukdb1	284	20	correct	correct	JJ
cord-295807-68sukdb1	284	21	generation	generation	NN
cord-295807-68sukdb1	284	22	of	of	IN
cord-295807-68sukdb1	284	23	endolymph	endolymph	NNP
cord-295807-68sukdb1	284	24	or	or	CC
cord-295807-68sukdb1	284	25	ostoconia	ostoconia	NNP
cord-295807-68sukdb1	284	26	.	.	.
cord-295807-68sukdb1	285	1	On	on	IN
cord-295807-68sukdb1	285	2	a	a	DT
cord-295807-68sukdb1	285	3	related	relate	VBN
cord-295807-68sukdb1	285	4	topic	topic	NN
cord-295807-68sukdb1	285	5	there	there	EX
cord-295807-68sukdb1	285	6	is	be	VBZ
cord-295807-68sukdb1	285	7	one	one	CD
cord-295807-68sukdb1	285	8	side	side	NN
cord-295807-68sukdb1	285	9	effect	effect	NN
cord-295807-68sukdb1	285	10	of	of	IN
cord-295807-68sukdb1	285	11	ear	ear	NN
cord-295807-68sukdb1	285	12	drops	drop	NNS
cord-295807-68sukdb1	285	13	that	that	WDT
cord-295807-68sukdb1	285	14	pertains	pertain	VBZ
cord-295807-68sukdb1	285	15	to	to	IN
cord-295807-68sukdb1	285	16	acid	acid	NN
cord-295807-68sukdb1	285	17	-	-	HYPH
cord-295807-68sukdb1	285	18	base	base	NN
cord-295807-68sukdb1	285	19	balance	balance	NN
cord-295807-68sukdb1	285	20	.	.	.
cord-295807-68sukdb1	286	1	The	the	DT
cord-295807-68sukdb1	286	2	acetic	acetic	JJ
cord-295807-68sukdb1	286	3	acid	acid	NN
cord-295807-68sukdb1	286	4	in	in	IN
cord-295807-68sukdb1	286	5	some	some	DT
cord-295807-68sukdb1	286	6	ear	ear	NN
cord-295807-68sukdb1	286	7	drops	drop	VBZ
cord-295807-68sukdb1	286	8	used	use	VBN
cord-295807-68sukdb1	286	9	to	to	TO
cord-295807-68sukdb1	286	10	treat	treat	VB
cord-295807-68sukdb1	286	11	outer	outer	JJ
cord-295807-68sukdb1	286	12	ear	ear	NN
cord-295807-68sukdb1	286	13	infection	infection	NN
cord-295807-68sukdb1	286	14	can	can	MD
cord-295807-68sukdb1	286	15	be	be	VB
cord-295807-68sukdb1	286	16	ototoxic	ototoxic	JJ
cord-295807-68sukdb1	286	17	because	because	IN
cord-295807-68sukdb1	286	18	acetic	acetic	JJ
cord-295807-68sukdb1	286	19	acid	acid	NN
cord-295807-68sukdb1	286	20	can	can	MD
cord-295807-68sukdb1	286	21	move	move	VB
cord-295807-68sukdb1	286	22	across	across	IN
cord-295807-68sukdb1	286	23	the	the	DT
cord-295807-68sukdb1	286	24	round	round	JJ
cord-295807-68sukdb1	286	25	window	window	NN
cord-295807-68sukdb1	286	26	into	into	IN
cord-295807-68sukdb1	286	27	the	the	DT
cord-295807-68sukdb1	286	28	inner	inner	JJ
cord-295807-68sukdb1	286	29	ear	ear	NN
cord-295807-68sukdb1	286	30	,	,	,
cord-295807-68sukdb1	286	31	resulting	result	VBG
cord-295807-68sukdb1	286	32	in	in	IN
cord-295807-68sukdb1	286	33	a	a	DT
cord-295807-68sukdb1	286	34	drop	drop	NN
cord-295807-68sukdb1	286	35	in	in	IN
cord-295807-68sukdb1	286	36	endocochlear	endocochlear	JJ
cord-295807-68sukdb1	286	37	potential	potential	NN
cord-295807-68sukdb1	286	38	(	(	-LRB-
cord-295807-68sukdb1	286	39	perhaps	perhaps	RB
cord-295807-68sukdb1	286	40	by	by	IN
cord-295807-68sukdb1	286	41	acid	acid	JJ
cord-295807-68sukdb1	286	42	inhibition	inhibition	NN
cord-295807-68sukdb1	286	43	of	of	IN
cord-295807-68sukdb1	286	44	the	the	DT
cord-295807-68sukdb1	286	45	Na	Na	NNP
cord-295807-68sukdb1	286	46	+	+	CC
cord-295807-68sukdb1	286	47	/K	/K	.
cord-295807-68sukdb1	287	1	+	+	CC
cord-295807-68sukdb1	287	2	-ATPase	-atpase	NN
cord-295807-68sukdb1	287	3	)	)	-RRB-
cord-295807-68sukdb1	288	1	and	and	CC
cord-295807-68sukdb1	288	2	endolymph	endolymph	NNP
cord-295807-68sukdb1	288	3	and	and	CC
cord-295807-68sukdb1	288	4	perilymph	perilymph	NNP
cord-295807-68sukdb1	288	5	pH	pH	NNP
cord-295807-68sukdb1	288	6	[	[	-LRB-
cord-295807-68sukdb1	288	7	150	150	CD
cord-295807-68sukdb1	288	8	]	]	-RRB-
cord-295807-68sukdb1	288	9	.	.	.
cord-295807-68sukdb1	289	1	We	-PRON-	PRP
cord-295807-68sukdb1	289	2	are	be	VBP
cord-295807-68sukdb1	289	3	unaware	unaware	JJ
cord-295807-68sukdb1	289	4	of	of	IN
cord-295807-68sukdb1	289	5	any	any	DT
cord-295807-68sukdb1	289	6	demonstrations	demonstration	NNS
cord-295807-68sukdb1	289	7	of	of	IN
cord-295807-68sukdb1	289	8	the	the	DT
cord-295807-68sukdb1	289	9	usefulness	usefulness	NN
cord-295807-68sukdb1	289	10	of	of	IN
cord-295807-68sukdb1	289	11	OTOP1	otop1	NN
cord-295807-68sukdb1	289	12	modulation	modulation	NN
cord-295807-68sukdb1	289	13	in	in	IN
cord-295807-68sukdb1	289	14	this	this	DT
cord-295807-68sukdb1	289	15	area	area	NN
cord-295807-68sukdb1	289	16	,	,	,
cord-295807-68sukdb1	289	17	but	but	CC
cord-295807-68sukdb1	289	18	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	289	19	of	of	IN
cord-295807-68sukdb1	289	20	proteins	protein	NNS
cord-295807-68sukdb1	289	21	that	that	WDT
cord-295807-68sukdb1	289	22	mediate	mediate	VBP
cord-295807-68sukdb1	289	23	bitter	bitter	JJ
cord-295807-68sukdb1	289	24	taste	taste	NN
cord-295807-68sukdb1	289	25	sensation	sensation	NN
cord-295807-68sukdb1	289	26	have	have	VBP
cord-295807-68sukdb1	289	27	been	be	VBN
cord-295807-68sukdb1	289	28	used	use	VBN
cord-295807-68sukdb1	289	29	to	to	TO
cord-295807-68sukdb1	289	30	mask	mask	VB
cord-295807-68sukdb1	289	31	bitter	bitter	JJ
cord-295807-68sukdb1	289	32	tastes	taste	NNS
cord-295807-68sukdb1	289	33	,	,	,
cord-295807-68sukdb1	289	34	suggesting	suggest	VBG
cord-295807-68sukdb1	289	35	potential	potential	JJ
cord-295807-68sukdb1	289	36	utility	utility	NN
cord-295807-68sukdb1	289	37	of	of	IN
cord-295807-68sukdb1	289	38	OTOP1	otop1	NN
cord-295807-68sukdb1	289	39	block	block	NN
cord-295807-68sukdb1	289	40	for	for	IN
cord-295807-68sukdb1	289	41	masking	mask	VBG
cord-295807-68sukdb1	289	42	sour	sour	JJ
cord-295807-68sukdb1	289	43	tastes	taste	NNS
cord-295807-68sukdb1	289	44	and	and	CC
cord-295807-68sukdb1	289	45	increasing	increase	VBG
cord-295807-68sukdb1	289	46	the	the	DT
cord-295807-68sukdb1	289	47	palatability	palatability	NN
cord-295807-68sukdb1	289	48	of	of	IN
cord-295807-68sukdb1	289	49	sour	sour	JJ
cord-295807-68sukdb1	289	50	-	-	HYPH
cord-295807-68sukdb1	289	51	tasting	taste	VBG
cord-295807-68sukdb1	289	52	medications	medication	NNS
cord-295807-68sukdb1	289	53	[	[	-LRB-
cord-295807-68sukdb1	289	54	151	151	CD
cord-295807-68sukdb1	289	55	,	,	,
cord-295807-68sukdb1	289	56	152	152	CD
cord-295807-68sukdb1	289	57	]	]	-RRB-
cord-295807-68sukdb1	289	58	.	.	.
cord-295807-68sukdb1	290	1	Pain	pain	NN
cord-295807-68sukdb1	290	2	sensation	sensation	NN
cord-295807-68sukdb1	290	3	.	.	.
cord-295807-68sukdb1	291	1	Adjuvant	Adjuvant	NNP
cord-295807-68sukdb1	291	2	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	291	3	raises	raise	VBZ
cord-295807-68sukdb1	291	4	the	the	DT
cord-295807-68sukdb1	291	5	pH	ph	NN
cord-295807-68sukdb1	291	6	of	of	IN
cord-295807-68sukdb1	291	7	an	an	DT
cord-295807-68sukdb1	291	8	injectable	injectable	JJ
cord-295807-68sukdb1	291	9	lidocaine	lidocaine	NN
cord-295807-68sukdb1	291	10	solution	solution	NN
cord-295807-68sukdb1	291	11	and	and	CC
cord-295807-68sukdb1	291	12	lowers	lower	VBZ
cord-295807-68sukdb1	291	13	perception	perception	NN
cord-295807-68sukdb1	291	14	of	of	IN
cord-295807-68sukdb1	291	15	pain	pain	NN
cord-295807-68sukdb1	291	16	associated	associate	VBN
cord-295807-68sukdb1	291	17	with	with	IN
cord-295807-68sukdb1	291	18	lidocaine	lidocaine	NN
cord-295807-68sukdb1	291	19	injection	injection	NN
cord-295807-68sukdb1	291	20	in	in	IN
cord-295807-68sukdb1	291	21	one	one	CD
cord-295807-68sukdb1	291	22	study	study	NN
cord-295807-68sukdb1	291	23	,	,	,
cord-295807-68sukdb1	291	24	but	but	CC
cord-295807-68sukdb1	291	25	the	the	DT
cord-295807-68sukdb1	291	26	mechanism	mechanism	NN
cord-295807-68sukdb1	291	27	of	of	IN
cord-295807-68sukdb1	291	28	the	the	DT
cord-295807-68sukdb1	291	29	effect	effect	NN
cord-295807-68sukdb1	291	30	is	be	VBZ
cord-295807-68sukdb1	291	31	uncertain	uncertain	JJ
cord-295807-68sukdb1	291	32	[	[	-LRB-
cord-295807-68sukdb1	291	33	153	153	CD
cord-295807-68sukdb1	291	34	]	]	-RRB-
cord-295807-68sukdb1	291	35	.	.	.
cord-295807-68sukdb1	292	1	See	see	VB
cord-295807-68sukdb1	292	2	also	also	RB
cord-295807-68sukdb1	292	3	sections	section	VBZ
cord-295807-68sukdb1	292	4	5.2	5.2	CD
cord-295807-68sukdb1	292	5	(	(	-LRB-
cord-295807-68sukdb1	292	6	Anesthesiology	Anesthesiology	NNP
cord-295807-68sukdb1	292	7	)	)	-RRB-
cord-295807-68sukdb1	292	8	.	.	.
cord-295807-68sukdb1	293	1	Besides	besides	IN
cord-295807-68sukdb1	293	2	the	the	DT
cord-295807-68sukdb1	293	3	increased	increase	VBN
cord-295807-68sukdb1	293	4	respiratory	respiratory	JJ
cord-295807-68sukdb1	293	5	drive	drive	NN
cord-295807-68sukdb1	293	6	to	to	TO
cord-295807-68sukdb1	293	7	exhale	exhale	VB
cord-295807-68sukdb1	293	8	CO2	co2	NN
cord-295807-68sukdb1	293	9	in	in	IN
cord-295807-68sukdb1	293	10	response	response	NN
cord-295807-68sukdb1	293	11	to	to	IN
cord-295807-68sukdb1	293	12	RAc	RAc	NNP
cord-295807-68sukdb1	293	13	[	[	-LRB-
cord-295807-68sukdb1	293	14	4	4	CD
cord-295807-68sukdb1	293	15	]	]	-RRB-
cord-295807-68sukdb1	293	16	and	and	CC
cord-295807-68sukdb1	293	17	the	the	DT
cord-295807-68sukdb1	293	18	Bohr	Bohr	NNP
cord-295807-68sukdb1	293	19	effect	effect	NN
cord-295807-68sukdb1	293	20	(	(	-LRB-
cord-295807-68sukdb1	293	21	see	see	VB
cord-295807-68sukdb1	293	22	section	section	NN
cord-295807-68sukdb1	293	23	4.4	4.4	CD
cord-295807-68sukdb1	293	24	The	the	DT
cord-295807-68sukdb1	293	25	Circulatory	circulatory	JJ
cord-295807-68sukdb1	293	26	System	system	NN
cord-295807-68sukdb1	293	27	)	)	-RRB-
cord-295807-68sukdb1	294	1	the	the	DT
cord-295807-68sukdb1	294	2	highest	high	JJS
cord-295807-68sukdb1	294	3	profile	profile	NN
cord-295807-68sukdb1	294	4	link	link	NN
cord-295807-68sukdb1	294	5	between	between	IN
cord-295807-68sukdb1	294	6	pH	ph	NN
cord-295807-68sukdb1	294	7	and	and	CC
cord-295807-68sukdb1	294	8	respiration	respiration	NN
cord-295807-68sukdb1	294	9	relates	relate	VBZ
cord-295807-68sukdb1	294	10	to	to	IN
cord-295807-68sukdb1	294	11	the	the	DT
cord-295807-68sukdb1	294	12	role	role	NN
cord-295807-68sukdb1	294	13	of	of	IN
cord-295807-68sukdb1	294	14	CFTR	CFTR	NNP
cord-295807-68sukdb1	294	15	.	.	.
cord-295807-68sukdb1	295	1	Defects	defect	NNS
cord-295807-68sukdb1	295	2	in	in	IN
cord-295807-68sukdb1	295	3	CFTR	CFTR	NNP
cord-295807-68sukdb1	295	4	are	be	VBP
cord-295807-68sukdb1	295	5	devastating	devastating	JJ
cord-295807-68sukdb1	295	6	because	because	IN
cord-295807-68sukdb1	295	7	the	the	DT
cord-295807-68sukdb1	295	8	Cland	Cland	NNP
cord-295807-68sukdb1	295	9	HCO3secretion	HCO3secretion	NNP
cord-295807-68sukdb1	295	10	that	that	IN
cord-295807-68sukdb1	295	11	this	this	DT
cord-295807-68sukdb1	295	12	channel	channel	NN
cord-295807-68sukdb1	295	13	normally	normally	RB
cord-295807-68sukdb1	295	14	mediates	mediate	VBZ
cord-295807-68sukdb1	295	15	is	be	VBZ
cord-295807-68sukdb1	295	16	a	a	DT
cord-295807-68sukdb1	295	17	fundamental	fundamental	JJ
cord-295807-68sukdb1	295	18	part	part	NN
cord-295807-68sukdb1	295	19	of	of	IN
cord-295807-68sukdb1	295	20	the	the	DT
cord-295807-68sukdb1	295	21	mechanisms	mechanism	NNS
cord-295807-68sukdb1	295	22	that	that	WDT
cord-295807-68sukdb1	295	23	drive	drive	VBP
cord-295807-68sukdb1	295	24	fluid	fluid	JJ
cord-295807-68sukdb1	295	25	secretion	secretion	NN
cord-295807-68sukdb1	295	26	in	in	IN
cord-295807-68sukdb1	295	27	our	-PRON-	PRP$
cord-295807-68sukdb1	295	28	bodies	body	NNS
cord-295807-68sukdb1	295	29	[	[	-LRB-
cord-295807-68sukdb1	295	30	154	154	CD
cord-295807-68sukdb1	295	31	]	]	-RRB-
cord-295807-68sukdb1	296	1	(	(	-LRB-
cord-295807-68sukdb1	296	2	Figure	figure	NN
cord-295807-68sukdb1	296	3	6	6	CD
cord-295807-68sukdb1	296	4	)	)	-RRB-
cord-295807-68sukdb1	296	5	.	.	.
cord-295807-68sukdb1	297	1	The	the	DT
cord-295807-68sukdb1	297	2	majority	majority	NN
cord-295807-68sukdb1	297	3	of	of	IN
cord-295807-68sukdb1	297	4	deaths	death	NNS
cord-295807-68sukdb1	297	5	associated	associate	VBN
cord-295807-68sukdb1	297	6	with	with	IN
cord-295807-68sukdb1	297	7	CF	CF	NNP
cord-295807-68sukdb1	297	8	are	be	VBP
cord-295807-68sukdb1	297	9	caused	cause	VBN
cord-295807-68sukdb1	297	10	by	by	IN
cord-295807-68sukdb1	297	11	respiratory	respiratory	JJ
cord-295807-68sukdb1	297	12	failure	failure	NN
cord-295807-68sukdb1	297	13	[	[	-LRB-
cord-295807-68sukdb1	297	14	155	155	CD
cord-295807-68sukdb1	297	15	]	]	-RRB-
cord-295807-68sukdb1	297	16	.	.	.
cord-295807-68sukdb1	298	1	In	in	IN
cord-295807-68sukdb1	298	2	the	the	DT
cord-295807-68sukdb1	298	3	lungs	lung	NNS
cord-295807-68sukdb1	298	4	,	,	,
cord-295807-68sukdb1	298	5	secretions	secretion	NNS
cord-295807-68sukdb1	298	6	are	be	VBP
cord-295807-68sukdb1	298	7	required	require	VBN
cord-295807-68sukdb1	298	8	to	to	TO
cord-295807-68sukdb1	298	9	provide	provide	VB
cord-295807-68sukdb1	298	10	a	a	DT
cord-295807-68sukdb1	298	11	moist	moist	JJ
cord-295807-68sukdb1	298	12	surface	surface	NN
cord-295807-68sukdb1	298	13	for	for	IN
cord-295807-68sukdb1	298	14	gas	gas	NN
cord-295807-68sukdb1	298	15	exchange	exchange	NN
cord-295807-68sukdb1	298	16	,	,	,
cord-295807-68sukdb1	298	17	to	to	TO
cord-295807-68sukdb1	298	18	liquefy	liquefy	VB
cord-295807-68sukdb1	298	19	mucus	mucus	NN
cord-295807-68sukdb1	298	20	,	,	,
cord-295807-68sukdb1	298	21	and	and	CC
cord-295807-68sukdb1	298	22	to	to	TO
cord-295807-68sukdb1	298	23	flush	flush	VB
cord-295807-68sukdb1	298	24	inhaled	inhale	VBN
cord-295807-68sukdb1	298	25	particles	particle	NNS
cord-295807-68sukdb1	298	26	and	and	CC
cord-295807-68sukdb1	298	27	pathogens	pathogen	NNS
cord-295807-68sukdb1	298	28	out	out	RP
cord-295807-68sukdb1	298	29	towards	towards	IN
cord-295807-68sukdb1	298	30	the	the	DT
cord-295807-68sukdb1	298	31	throat	throat	NN
cord-295807-68sukdb1	298	32	(	(	-LRB-
cord-295807-68sukdb1	298	33	mucociliary	mucociliary	JJ
cord-295807-68sukdb1	298	34	clearance	clearance	NN
cord-295807-68sukdb1	298	35	)	)	-RRB-
cord-295807-68sukdb1	298	36	.	.	.
cord-295807-68sukdb1	299	1	Besides	besides	IN
cord-295807-68sukdb1	299	2	the	the	DT
cord-295807-68sukdb1	299	3	general	general	JJ
cord-295807-68sukdb1	299	4	importance	importance	NN
cord-295807-68sukdb1	299	5	of	of	IN
cord-295807-68sukdb1	299	6	anion	anion	NN
cord-295807-68sukdb1	299	7	secretion	secretion	NN
cord-295807-68sukdb1	299	8	,	,	,
cord-295807-68sukdb1	299	9	CFTR	CFTR	NNP
cord-295807-68sukdb1	299	10	-	-	HYPH
cord-295807-68sukdb1	299	11	mediated	mediate	VBN
cord-295807-68sukdb1	299	12	HCO3secretion	HCO3secretion	NNP
cord-295807-68sukdb1	299	13	plays	play	VBZ
cord-295807-68sukdb1	299	14	a	a	DT
cord-295807-68sukdb1	299	15	further	further	JJ
cord-295807-68sukdb1	299	16	role	role	NN
cord-295807-68sukdb1	299	17	in	in	IN
cord-295807-68sukdb1	299	18	pH	pH	NNP
cord-295807-68sukdb1	299	19	homeostasis	homeostasis	NN
cord-295807-68sukdb1	299	20	in	in	IN
cord-295807-68sukdb1	299	21	the	the	DT
cord-295807-68sukdb1	299	22	airway	airway	NN
cord-295807-68sukdb1	299	23	surface	surface	NN
cord-295807-68sukdb1	299	24	liquid	liquid	NN
cord-295807-68sukdb1	299	25	(	(	-LRB-
cord-295807-68sukdb1	299	26	ASL	ASL	NNP
cord-295807-68sukdb1	299	27	)	)	-RRB-
cord-295807-68sukdb1	299	28	;	;	:
cord-295807-68sukdb1	299	29	HCO3helps	HCO3helps	NNP
cord-295807-68sukdb1	299	30	to	to	TO
cord-295807-68sukdb1	299	31	unfold	unfold	VB
cord-295807-68sukdb1	299	32	and	and	CC
cord-295807-68sukdb1	299	33	hydrate	hydrate	VB
cord-295807-68sukdb1	299	34	mucus	mucus	NN
cord-295807-68sukdb1	299	35	[	[	-LRB-
cord-295807-68sukdb1	299	36	156	156	CD
cord-295807-68sukdb1	299	37	]	]	-RRB-
cord-295807-68sukdb1	299	38	and	and	CC
cord-295807-68sukdb1	299	39	,	,	,
cord-295807-68sukdb1	299	40	by	by	IN
cord-295807-68sukdb1	299	41	defending	defend	VBG
cord-295807-68sukdb1	299	42	airway	airway	NNP
cord-295807-68sukdb1	299	43	pH	pH	NNP
cord-295807-68sukdb1	299	44	,	,	,
cord-295807-68sukdb1	299	45	has	have	VBZ
cord-295807-68sukdb1	299	46	been	be	VBN
cord-295807-68sukdb1	299	47	hypothesized	hypothesize	VBN
cord-295807-68sukdb1	299	48	to	to	TO
cord-295807-68sukdb1	299	49	promote	promote	VB
cord-295807-68sukdb1	299	50	a	a	DT
cord-295807-68sukdb1	299	51	healthy	healthy	JJ
cord-295807-68sukdb1	299	52	local	local	JJ
cord-295807-68sukdb1	299	53	immune	immune	JJ
cord-295807-68sukdb1	299	54	response	response	NN
cord-295807-68sukdb1	299	55	to	to	IN
cord-295807-68sukdb1	299	56	airway	airway	NN
cord-295807-68sukdb1	299	57	bacteria	bacteria	NNS
cord-295807-68sukdb1	299	58	[	[	-LRB-
cord-295807-68sukdb1	299	59	157	157	CD
cord-295807-68sukdb1	299	60	,	,	,
cord-295807-68sukdb1	299	61	158	158	CD
cord-295807-68sukdb1	299	62	]	]	-RRB-
cord-295807-68sukdb1	299	63	.	.	.
cord-295807-68sukdb1	300	1	HCO3secretion	hco3secretion	NN
cord-295807-68sukdb1	300	2	is	be	VBZ
cord-295807-68sukdb1	300	3	modulated	modulate	VBN
cord-295807-68sukdb1	300	4	by	by	IN
cord-295807-68sukdb1	300	5	epithelial	epithelial	JJ
cord-295807-68sukdb1	300	6	H	h	NN
cord-295807-68sukdb1	300	7	+	+	CC
cord-295807-68sukdb1	300	8	secretion	secretion	NN
cord-295807-68sukdb1	300	9	mediated	mediate	VBN
cord-295807-68sukdb1	300	10	by	by	IN
cord-295807-68sukdb1	300	11	a	a	DT
cord-295807-68sukdb1	300	12	host	host	NN
cord-295807-68sukdb1	300	13	of	of	IN
cord-295807-68sukdb1	300	14	acid	acid	NN
cord-295807-68sukdb1	300	15	-	-	HYPH
cord-295807-68sukdb1	300	16	extruding	extrude	VBG
cord-295807-68sukdb1	300	17	transporters	transporter	NNS
cord-295807-68sukdb1	300	18	[	[	-LRB-
cord-295807-68sukdb1	300	19	159	159	CD
cord-295807-68sukdb1	300	20	]	]	-RRB-
cord-295807-68sukdb1	301	1	(	(	-LRB-
cord-295807-68sukdb1	301	2	Figure	figure	NN
cord-295807-68sukdb1	301	3	6	6	CD
cord-295807-68sukdb1	301	4	)	)	-RRB-
cord-295807-68sukdb1	301	5	.	.	.
cord-295807-68sukdb1	302	1	Airway	airway	JJ
cord-295807-68sukdb1	302	2	acidification	acidification	NN
cord-295807-68sukdb1	302	3	is	be	VBZ
cord-295807-68sukdb1	302	4	a	a	DT
cord-295807-68sukdb1	302	5	feature	feature	NN
cord-295807-68sukdb1	302	6	of	of	IN
cord-295807-68sukdb1	302	7	individuals	individual	NNS
cord-295807-68sukdb1	302	8	with	with	IN
cord-295807-68sukdb1	302	9	cystic	cystic	JJ
cord-295807-68sukdb1	302	10	fibrosis	fibrosis	NN
cord-295807-68sukdb1	302	11	,	,	,
cord-295807-68sukdb1	302	12	as	as	RB
cord-295807-68sukdb1	302	13	well	well	RB
cord-295807-68sukdb1	302	14	as	as	IN
cord-295807-68sukdb1	302	15	those	those	DT
cord-295807-68sukdb1	302	16	with	with	IN
cord-295807-68sukdb1	302	17	asthma	asthma	NN
cord-295807-68sukdb1	302	18	and	and	CC
cord-295807-68sukdb1	302	19	tuberculosis	tuberculosis	NN
cord-295807-68sukdb1	302	20	[	[	-LRB-
cord-295807-68sukdb1	302	21	160	160	CD
cord-295807-68sukdb1	302	22	]	]	-RRB-
cord-295807-68sukdb1	302	23	and	and	CC
cord-295807-68sukdb1	302	24	is	be	VBZ
cord-295807-68sukdb1	302	25	exacerbated	exacerbate	VBN
cord-295807-68sukdb1	302	26	by	by	IN
cord-295807-68sukdb1	302	27	lactic	lactic	JJ
cord-295807-68sukdb1	302	28	acid	acid	NN
cord-295807-68sukdb1	302	29	production	production	NN
cord-295807-68sukdb1	302	30	by	by	IN
cord-295807-68sukdb1	302	31	airway	airway	NN
cord-295807-68sukdb1	302	32	pathogens	pathogen	NNS
cord-295807-68sukdb1	302	33	and	and	CC
cord-295807-68sukdb1	302	34	airway	airway	NN
cord-295807-68sukdb1	302	35	epithelia	epithelium	NNS
cord-295807-68sukdb1	302	36	[	[	-LRB-
cord-295807-68sukdb1	302	37	161	161	CD
cord-295807-68sukdb1	302	38	]	]	-RRB-
cord-295807-68sukdb1	302	39	.	.	.
cord-295807-68sukdb1	303	1	The	the	DT
cord-295807-68sukdb1	303	2	new	new	JJ
cord-295807-68sukdb1	303	3	personalized	personalized	JJ
cord-295807-68sukdb1	303	4	CF	cf	NN
cord-295807-68sukdb1	303	5	therapies	therapy	NNS
cord-295807-68sukdb1	303	6	have	have	VBP
cord-295807-68sukdb1	303	7	focused	focus	VBN
cord-295807-68sukdb1	303	8	on	on	IN
cord-295807-68sukdb1	303	9	stimulation	stimulation	NN
cord-295807-68sukdb1	303	10	of	of	IN
cord-295807-68sukdb1	303	11	defective	defective	JJ
cord-295807-68sukdb1	303	12	CFTR	CFTR	NNP
cord-295807-68sukdb1	303	13	to	to	TO
cord-295807-68sukdb1	303	14	restore	restore	VB
cord-295807-68sukdb1	303	15	fluid	fluid	JJ
cord-295807-68sukdb1	303	16	secretion	secretion	NN
cord-295807-68sukdb1	303	17	[	[	-LRB-
cord-295807-68sukdb1	303	18	162	162	CD
cord-295807-68sukdb1	303	19	]	]	-RRB-
cord-295807-68sukdb1	303	20	,	,	,
cord-295807-68sukdb1	303	21	but	but	CC
cord-295807-68sukdb1	303	22	are	be	VBP
cord-295807-68sukdb1	303	23	targeted	target	VBN
cord-295807-68sukdb1	303	24	to	to	IN
cord-295807-68sukdb1	303	25	individuals	individual	NNS
cord-295807-68sukdb1	303	26	with	with	IN
cord-295807-68sukdb1	303	27	specific	specific	JJ
cord-295807-68sukdb1	303	28	CF	cf	NN
cord-295807-68sukdb1	303	29	genotypes	genotype	NNS
cord-295807-68sukdb1	303	30	and	and	CC
cord-295807-68sukdb1	303	31	thus	thus	RB
cord-295807-68sukdb1	303	32	alternative	alternative	JJ
cord-295807-68sukdb1	303	33	general	general	JJ
cord-295807-68sukdb1	303	34	therapies	therapy	NNS
cord-295807-68sukdb1	303	35	are	be	VBP
cord-295807-68sukdb1	303	36	still	still	RB
cord-295807-68sukdb1	303	37	required	require	VBN
cord-295807-68sukdb1	303	38	.	.	.
cord-295807-68sukdb1	304	1	Strategies	strategy	NNS
cord-295807-68sukdb1	304	2	specifically	specifically	RB
cord-295807-68sukdb1	304	3	focused	focus	VBD
cord-295807-68sukdb1	304	4	on	on	IN
cord-295807-68sukdb1	304	5	correcting	correct	VBG
cord-295807-68sukdb1	304	6	ASL	ASL	NNP
cord-295807-68sukdb1	304	7	pH	pH	NNP
cord-295807-68sukdb1	304	8	include	include	VB
cord-295807-68sukdb1	304	9	inhalation	inhalation	NN
cord-295807-68sukdb1	304	10	of	of	IN
cord-295807-68sukdb1	304	11	nebulized	nebulize	VBN
cord-295807-68sukdb1	304	12	bases	basis	NNS
cord-295807-68sukdb1	304	13	such	such	JJ
cord-295807-68sukdb1	304	14	as	as	IN
cord-295807-68sukdb1	304	15	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	304	16	[	[	-LRB-
cord-295807-68sukdb1	304	17	163	163	CD
cord-295807-68sukdb1	304	18	,	,	,
cord-295807-68sukdb1	304	19	164	164	CD
cord-295807-68sukdb1	304	20	]	]	-RRB-
cord-295807-68sukdb1	304	21	and	and	CC
cord-295807-68sukdb1	304	22	THAM	THAM	NNP
cord-295807-68sukdb1	304	23	[	[	-LRB-
cord-295807-68sukdb1	304	24	165	165	CD
cord-295807-68sukdb1	304	25	]	]	-RRB-
cord-295807-68sukdb1	304	26	as	as	RB
cord-295807-68sukdb1	304	27	well	well	RB
cord-295807-68sukdb1	304	28	as	as	IN
cord-295807-68sukdb1	304	29	block	block	NN
cord-295807-68sukdb1	304	30	of	of	IN
cord-295807-68sukdb1	304	31	airway	airway	NN
cord-295807-68sukdb1	304	32	H	h	NN
cord-295807-68sukdb1	304	33	+	+	CC
cord-295807-68sukdb1	304	34	secretion	secretion	NN
cord-295807-68sukdb1	304	35	using	use	VBG
cord-295807-68sukdb1	304	36	H	h	NN
cord-295807-68sukdb1	304	37	+	+	CC
cord-295807-68sukdb1	304	38	/K	/K	.
cord-295807-68sukdb1	305	1	+	+	CC
cord-295807-68sukdb1	305	2	-ATPase	-atpase	NN
cord-295807-68sukdb1	306	1	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	306	2	[	[	-LRB-
cord-295807-68sukdb1	306	3	166	166	CD
cord-295807-68sukdb1	306	4	]	]	-RRB-
cord-295807-68sukdb1	306	5	.	.	.
cord-295807-68sukdb1	307	1	All	all	PDT
cord-295807-68sukdb1	307	2	these	these	DT
cord-295807-68sukdb1	307	3	strategies	strategy	NNS
cord-295807-68sukdb1	307	4	result	result	VBP
cord-295807-68sukdb1	307	5	in	in	IN
cord-295807-68sukdb1	307	6	improvements	improvement	NNS
cord-295807-68sukdb1	307	7	in	in	IN
cord-295807-68sukdb1	307	8	ASL	ASL	NNP
cord-295807-68sukdb1	307	9	pH	ph	NN
cord-295807-68sukdb1	307	10	and	and	CC
cord-295807-68sukdb1	307	11	some	some	DT
cord-295807-68sukdb1	307	12	also	also	RB
cord-295807-68sukdb1	307	13	improve	improve	VBP
cord-295807-68sukdb1	307	14	mucus	mucus	NN
cord-295807-68sukdb1	307	15	viscosity	viscosity	NN
cord-295807-68sukdb1	307	16	and/or	and/or	CC
cord-295807-68sukdb1	307	17	pathogen	pathogen	NN
cord-295807-68sukdb1	307	18	clearance	clearance	NN
cord-295807-68sukdb1	307	19	.	.	.
cord-295807-68sukdb1	308	1	An	an	DT
cord-295807-68sukdb1	308	2	in	in	IN
cord-295807-68sukdb1	308	3	vitro	vitro	FW
cord-295807-68sukdb1	308	4	study	study	NN
cord-295807-68sukdb1	308	5	suggests	suggest	VBZ
cord-295807-68sukdb1	308	6	that	that	IN
cord-295807-68sukdb1	308	7	MCT2	MCT2	NNP
cord-295807-68sukdb1	308	8	blockade	blockade	NN
cord-295807-68sukdb1	308	9	could	could	MD
cord-295807-68sukdb1	308	10	also	also	RB
cord-295807-68sukdb1	308	11	be	be	VB
cord-295807-68sukdb1	308	12	protective	protective	JJ
cord-295807-68sukdb1	308	13	of	of	IN
cord-295807-68sukdb1	308	14	ASL	ASL	NNP
cord-295807-68sukdb1	308	15	pH	ph	NN
cord-295807-68sukdb1	308	16	in	in	IN
cord-295807-68sukdb1	308	17	individuals	individual	NNS
cord-295807-68sukdb1	308	18	with	with	IN
cord-295807-68sukdb1	308	19	CF	CF	NNP
cord-295807-68sukdb1	308	20	[	[	-LRB-
cord-295807-68sukdb1	308	21	161	161	CD
cord-295807-68sukdb1	308	22	]	]	-RRB-
cord-295807-68sukdb1	308	23	by	by	IN
cord-295807-68sukdb1	308	24	reducing	reduce	VBG
cord-295807-68sukdb1	308	25	epithelial	epithelial	JJ
cord-295807-68sukdb1	308	26	H	h	NN
cord-295807-68sukdb1	308	27	+	+	CC
cord-295807-68sukdb1	308	28	secretion	secretion	NN
cord-295807-68sukdb1	308	29	.	.	.
cord-295807-68sukdb1	309	1	A	a	DT
cord-295807-68sukdb1	309	2	newly	newly	RB
cord-295807-68sukdb1	309	3	described	describe	VBN
cord-295807-68sukdb1	309	4	paracellular	paracellular	JJ
cord-295807-68sukdb1	309	5	pathway	pathway	NN
cord-295807-68sukdb1	309	6	for	for	IN
cord-295807-68sukdb1	309	7	HCO3secretion	HCO3secretion	NNP
cord-295807-68sukdb1	309	8	by	by	IN
cord-295807-68sukdb1	309	9	CF	CF	NNP
cord-295807-68sukdb1	309	10	airway	airway	NN
cord-295807-68sukdb1	309	11	epithelia	epithelium	NNS
cord-295807-68sukdb1	309	12	might	may	MD
cord-295807-68sukdb1	309	13	also	also	RB
cord-295807-68sukdb1	309	14	be	be	VB
cord-295807-68sukdb1	309	15	amenable	amenable	JJ
cord-295807-68sukdb1	309	16	to	to	IN
cord-295807-68sukdb1	309	17	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	309	18	modulation	modulation	NN
cord-295807-68sukdb1	309	19	[	[	-LRB-
cord-295807-68sukdb1	309	20	167	167	CD
cord-295807-68sukdb1	309	21	]	]	-RRB-
cord-295807-68sukdb1	309	22	.	.	.
cord-295807-68sukdb1	310	1	The	the	DT
cord-295807-68sukdb1	310	2	new	new	JJ
cord-295807-68sukdb1	310	3	personalized	personalized	JJ
cord-295807-68sukdb1	310	4	CF	cf	NN
cord-295807-68sukdb1	310	5	therapies	therapy	NNS
cord-295807-68sukdb1	310	6	have	have	VBP
cord-295807-68sukdb1	310	7	focused	focus	VBN
cord-295807-68sukdb1	310	8	on	on	IN
cord-295807-68sukdb1	310	9	stimulation	stimulation	NN
cord-295807-68sukdb1	310	10	of	of	IN
cord-295807-68sukdb1	310	11	defective	defective	JJ
cord-295807-68sukdb1	310	12	CFTR	CFTR	NNP
cord-295807-68sukdb1	310	13	to	to	TO
cord-295807-68sukdb1	310	14	restore	restore	VB
cord-295807-68sukdb1	310	15	fluid	fluid	JJ
cord-295807-68sukdb1	310	16	secretion	secretion	NN
cord-295807-68sukdb1	310	17	[	[	-LRB-
cord-295807-68sukdb1	310	18	159	159	CD
cord-295807-68sukdb1	310	19	]	]	-RRB-
cord-295807-68sukdb1	310	20	(	(	-LRB-
cord-295807-68sukdb1	310	21	e.g.	e.g.	IN
cord-295807-68sukdb1	310	22	lumafactor	lumafactor	NN
cord-295807-68sukdb1	310	23	/	/	SYM
cord-295807-68sukdb1	310	24	ivacaftor	ivacaftor	NNP
cord-295807-68sukdb1	310	25	,	,	,
cord-295807-68sukdb1	310	26	see	see	VB
cord-295807-68sukdb1	310	27	section	section	NN
cord-295807-68sukdb1	310	28	2.2.7	2.2.7	CD
cord-295807-68sukdb1	310	29	)	)	-RRB-
cord-295807-68sukdb1	310	30	,	,	,
cord-295807-68sukdb1	310	31	but	but	CC
cord-295807-68sukdb1	310	32	are	be	VBP
cord-295807-68sukdb1	310	33	targeted	target	VBN
cord-295807-68sukdb1	310	34	.	.	.
cord-295807-68sukdb1	311	1	Heart	heart	NN
cord-295807-68sukdb1	311	2	.	.	.
cord-295807-68sukdb1	312	1	MAc	MAc	NNP
cord-295807-68sukdb1	312	2	is	be	VBZ
cord-295807-68sukdb1	312	3	associated	associate	VBN
cord-295807-68sukdb1	312	4	with	with	IN
cord-295807-68sukdb1	312	5	reduced	reduce	VBN
cord-295807-68sukdb1	312	6	cardiac	cardiac	JJ
cord-295807-68sukdb1	312	7	contractility	contractility	NN
cord-295807-68sukdb1	312	8	.	.	.
cord-295807-68sukdb1	313	1	This	this	DT
cord-295807-68sukdb1	313	2	phenomenon	phenomenon	NN
cord-295807-68sukdb1	313	3	is	be	VBZ
cord-295807-68sukdb1	313	4	explained	explain	VBN
cord-295807-68sukdb1	313	5	by	by	IN
cord-295807-68sukdb1	313	6	diverse	diverse	JJ
cord-295807-68sukdb1	313	7	mechanistic	mechanistic	JJ
cord-295807-68sukdb1	313	8	elements	element	NNS
cord-295807-68sukdb1	313	9	such	such	JJ
cord-295807-68sukdb1	313	10	as	as	IN
cord-295807-68sukdb1	313	11	the	the	DT
cord-295807-68sukdb1	313	12	pH	ph	NN
cord-295807-68sukdb1	313	13	-	-	NN
cord-295807-68sukdb1	313	14	dependence	dependence	NN
cord-295807-68sukdb1	313	15	of	of	IN
cord-295807-68sukdb1	313	16	the	the	DT
cord-295807-68sukdb1	313	17	channels	channel	NNS
cord-295807-68sukdb1	313	18	and	and	CC
cord-295807-68sukdb1	313	19	transporters	transporter	NNS
cord-295807-68sukdb1	313	20	that	that	WDT
cord-295807-68sukdb1	313	21	regulate	regulate	VBP
cord-295807-68sukdb1	313	22	Ca	Ca	NNP
cord-295807-68sukdb1	313	23	2	2	CD
cord-295807-68sukdb1	313	24	+	+	CC
cord-295807-68sukdb1	313	25	handling	handling	NN
cord-295807-68sukdb1	313	26	in	in	IN
cord-295807-68sukdb1	313	27	myocytes	myocyte	NNS
cord-295807-68sukdb1	313	28	as	as	RB
cord-295807-68sukdb1	313	29	well	well	RB
cord-295807-68sukdb1	313	30	as	as	IN
cord-295807-68sukdb1	313	31	the	the	DT
cord-295807-68sukdb1	313	32	dampening	dampening	NN
cord-295807-68sukdb1	313	33	effect	effect	NN
cord-295807-68sukdb1	313	34	of	of	IN
cord-295807-68sukdb1	313	35	acidosis	acidosis	NN
cord-295807-68sukdb1	313	36	on	on	IN
cord-295807-68sukdb1	313	37	the	the	DT
cord-295807-68sukdb1	313	38	responsiveness	responsiveness	NN
cord-295807-68sukdb1	313	39	of	of	IN
cord-295807-68sukdb1	313	40	the	the	DT
cord-295807-68sukdb1	313	41	contractile	contractile	JJ
cord-295807-68sukdb1	313	42	apparatus	apparatus	NN
cord-295807-68sukdb1	313	43	to	to	IN
cord-295807-68sukdb1	313	44	Ca	Ca	NNP
cord-295807-68sukdb1	313	45	2	2	CD
cord-295807-68sukdb1	313	46	+	+	CC
cord-295807-68sukdb1	313	47	[	[	-LRB-
cord-295807-68sukdb1	313	48	168	168	CD
cord-295807-68sukdb1	313	49	]	]	-RRB-
cord-295807-68sukdb1	313	50	.	.	.
cord-295807-68sukdb1	314	1	Whether	whether	IN
cord-295807-68sukdb1	314	2	the	the	DT
cord-295807-68sukdb1	314	3	heart	heart	NN
cord-295807-68sukdb1	314	4	rate	rate	NN
cord-295807-68sukdb1	314	5	is	be	VBZ
cord-295807-68sukdb1	314	6	lowered	lower	VBN
cord-295807-68sukdb1	314	7	by	by	IN
cord-295807-68sukdb1	314	8	acidosis	acidosis	NN
cord-295807-68sukdb1	314	9	is	be	VBZ
cord-295807-68sukdb1	314	10	harder	hard	JJR
cord-295807-68sukdb1	314	11	to	to	TO
cord-295807-68sukdb1	314	12	predict	predict	VB
cord-295807-68sukdb1	314	13	because	because	IN
cord-295807-68sukdb1	314	14	of	of	IN
cord-295807-68sukdb1	314	15	the	the	DT
cord-295807-68sukdb1	314	16	complex	complex	JJ
cord-295807-68sukdb1	314	17	effects	effect	NNS
cord-295807-68sukdb1	314	18	of	of	IN
cord-295807-68sukdb1	314	19	acidosis	acidosis	NN
cord-295807-68sukdb1	314	20	upon	upon	IN
cord-295807-68sukdb1	314	21	the	the	DT
cord-295807-68sukdb1	314	22	sympathoadrenal	sympathoadrenal	JJ
cord-295807-68sukdb1	314	23	system	system	NN
cord-295807-68sukdb1	314	24	[	[	-LRB-
cord-295807-68sukdb1	314	25	169	169	CD
cord-295807-68sukdb1	314	26	]	]	-RRB-
cord-295807-68sukdb1	314	27	.	.	.
cord-295807-68sukdb1	315	1	Intracellular	intracellular	JJ
cord-295807-68sukdb1	315	2	acidosis	acidosis	NN
cord-295807-68sukdb1	315	3	in	in	IN
cord-295807-68sukdb1	315	4	myocardial	myocardial	JJ
cord-295807-68sukdb1	315	5	infarction	infarction	NN
cord-295807-68sukdb1	315	6	after	after	IN
cord-295807-68sukdb1	315	7	a	a	DT
cord-295807-68sukdb1	315	8	period	period	NN
cord-295807-68sukdb1	315	9	of	of	IN
cord-295807-68sukdb1	315	10	ischemia	ischemia	NN
cord-295807-68sukdb1	315	11	,	,	,
cord-295807-68sukdb1	315	12	is	be	VBZ
cord-295807-68sukdb1	315	13	countered	counter	VBN
cord-295807-68sukdb1	315	14	,	,	,
cord-295807-68sukdb1	315	15	during	during	IN
cord-295807-68sukdb1	315	16	reperfusion	reperfusion	NN
cord-295807-68sukdb1	315	17	,	,	,
cord-295807-68sukdb1	315	18	by	by	IN
cord-295807-68sukdb1	315	19	the	the	DT
cord-295807-68sukdb1	315	20	action	action	NN
cord-295807-68sukdb1	315	21	of	of	IN
cord-295807-68sukdb1	315	22	acid	acid	NN
cord-295807-68sukdb1	315	23	-	-	HYPH
cord-295807-68sukdb1	315	24	extruders	extruder	NNS
cord-295807-68sukdb1	315	25	such	such	JJ
cord-295807-68sukdb1	315	26	as	as	IN
cord-295807-68sukdb1	315	27	NCBTs	ncbt	NNS
cord-295807-68sukdb1	315	28	and	and	CC
cord-295807-68sukdb1	315	29	NHEs	nhe	NNS
cord-295807-68sukdb1	315	30	[	[	-LRB-
cord-295807-68sukdb1	315	31	170	170	CD
cord-295807-68sukdb1	315	32	]	]	-RRB-
cord-295807-68sukdb1	315	33	.	.	.
cord-295807-68sukdb1	316	1	However	however	RB
cord-295807-68sukdb1	316	2	,	,	,
cord-295807-68sukdb1	316	3	the	the	DT
cord-295807-68sukdb1	316	4	accompanying	accompanying	JJ
cord-295807-68sukdb1	316	5	Na	Na	NNP
cord-295807-68sukdb1	316	6	+	+	CC
cord-295807-68sukdb1	316	7	load	load	NN
cord-295807-68sukdb1	316	8	can	can	MD
cord-295807-68sukdb1	316	9	be	be	VB
cord-295807-68sukdb1	316	10	sufficient	sufficient	JJ
cord-295807-68sukdb1	316	11	to	to	TO
cord-295807-68sukdb1	316	12	reverse	reverse	VB
cord-295807-68sukdb1	316	13	the	the	DT
cord-295807-68sukdb1	316	14	action	action	NN
cord-295807-68sukdb1	316	15	of	of	IN
cord-295807-68sukdb1	316	16	the	the	DT
cord-295807-68sukdb1	316	17	3Na	3na	NN
cord-295807-68sukdb1	317	1	+	+	CC
cord-295807-68sukdb1	318	1	/2Ca	/2Ca	NNP
cord-295807-68sukdb1	318	2	2	2	CD
cord-295807-68sukdb1	318	3	+	+	CC
cord-295807-68sukdb1	318	4	exchanger	exchanger	NN
cord-295807-68sukdb1	318	5	,	,	,
cord-295807-68sukdb1	318	6	raising	raise	VBG
cord-295807-68sukdb1	319	1	[	[	-LRB-
cord-295807-68sukdb1	319	2	Ca	Ca	NNP
cord-295807-68sukdb1	319	3	2	2	CD
cord-295807-68sukdb1	319	4	+	+	SYM
cord-295807-68sukdb1	319	5	]	]	-RRB-
cord-295807-68sukdb1	319	6	i	i	PRP
cord-295807-68sukdb1	319	7	and	and	CC
cord-295807-68sukdb1	319	8	increasing	increase	VBG
cord-295807-68sukdb1	319	9	susceptibility	susceptibility	NN
cord-295807-68sukdb1	319	10	to	to	IN
cord-295807-68sukdb1	319	11	ventricular	ventricular	JJ
cord-295807-68sukdb1	319	12	arrhythmias	arrhythmia	NNS
cord-295807-68sukdb1	319	13	[	[	-LRB-
cord-295807-68sukdb1	319	14	171	171	CD
cord-295807-68sukdb1	319	15	,	,	,
cord-295807-68sukdb1	319	16	172	172	CD
cord-295807-68sukdb1	319	17	]	]	-RRB-
cord-295807-68sukdb1	319	18	.	.	.
cord-295807-68sukdb1	320	1	Paradoxically	paradoxically	RB
cord-295807-68sukdb1	320	2	,	,	,
cord-295807-68sukdb1	320	3	the	the	DT
cord-295807-68sukdb1	320	4	loss	loss	NN
cord-295807-68sukdb1	320	5	of	of	IN
cord-295807-68sukdb1	320	6	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	320	7	function	function	NN
cord-295807-68sukdb1	320	8	can	can	MD
cord-295807-68sukdb1	320	9	also	also	RB
cord-295807-68sukdb1	320	10	result	result	VB
cord-295807-68sukdb1	320	11	in	in	IN
cord-295807-68sukdb1	320	12	Ca	Ca	NNP
cord-295807-68sukdb1	320	13	2	2	CD
cord-295807-68sukdb1	320	14	+	+	SYM
cord-295807-68sukdb1	320	15	overload	overload	NN
cord-295807-68sukdb1	320	16	because	because	IN
cord-295807-68sukdb1	320	17	compensatory	compensatory	JJ
cord-295807-68sukdb1	320	18	acid	acid	NN
cord-295807-68sukdb1	320	19	-	-	HYPH
cord-295807-68sukdb1	320	20	extrusion	extrusion	NN
cord-295807-68sukdb1	320	21	mediated	mediate	VBN
cord-295807-68sukdb1	320	22	by	by	IN
cord-295807-68sukdb1	320	23	NBCn1	NBCn1	NNP
cord-295807-68sukdb1	320	24	and	and	CC
cord-295807-68sukdb1	320	25	NHE1	NHE1	NNP
cord-295807-68sukdb1	320	26	imposes	impose	VBZ
cord-295807-68sukdb1	320	27	double	double	PDT
cord-295807-68sukdb1	320	28	the	the	DT
cord-295807-68sukdb1	320	29	Na	Na	NNP
cord-295807-68sukdb1	320	30	+	+	CC
cord-295807-68sukdb1	320	31	load	load	NN
cord-295807-68sukdb1	320	32	per	per	IN
cord-295807-68sukdb1	320	33	HCO3equivalent	HCO3equivalent	NNP
cord-295807-68sukdb1	320	34	;	;	:
cord-295807-68sukdb1	320	35	a	a	DT
cord-295807-68sukdb1	320	36	mechanism	mechanism	NN
cord-295807-68sukdb1	320	37	proposed	propose	VBN
cord-295807-68sukdb1	320	38	to	to	TO
cord-295807-68sukdb1	320	39	promote	promote	VB
cord-295807-68sukdb1	320	40	hypertrophy	hypertrophy	NN
cord-295807-68sukdb1	320	41	of	of	IN
cord-295807-68sukdb1	320	42	cardiomyocytes	cardiomyocyte	NNS
cord-295807-68sukdb1	320	43	in	in	IN
cord-295807-68sukdb1	320	44	spontaneously	spontaneously	RB
cord-295807-68sukdb1	320	45	hypertensive	hypertensive	JJ
cord-295807-68sukdb1	320	46	rats	rat	NNS
cord-295807-68sukdb1	320	47	[	[	-LRB-
cord-295807-68sukdb1	320	48	173	173	CD
cord-295807-68sukdb1	320	49	]	]	-RRB-
cord-295807-68sukdb1	320	50	.	.	.
cord-295807-68sukdb1	321	1	CA	CA	NNP
cord-295807-68sukdb1	321	2	activity	activity	NN
cord-295807-68sukdb1	321	3	is	be	VBZ
cord-295807-68sukdb1	321	4	also	also	RB
cord-295807-68sukdb1	321	5	pro	pro	JJ
cord-295807-68sukdb1	321	6	-	-	JJ
cord-295807-68sukdb1	321	7	hypertrophic	hypertrophic	JJ
cord-295807-68sukdb1	321	8	[	[	-LRB-
cord-295807-68sukdb1	321	9	174	174	CD
cord-295807-68sukdb1	321	10	]	]	-RRB-
cord-295807-68sukdb1	321	11	.	.	.
cord-295807-68sukdb1	322	1	On	on	IN
cord-295807-68sukdb1	322	2	the	the	DT
cord-295807-68sukdb1	322	3	other	other	JJ
cord-295807-68sukdb1	322	4	hand	hand	NN
cord-295807-68sukdb1	322	5	,	,	,
cord-295807-68sukdb1	322	6	the	the	DT
cord-295807-68sukdb1	322	7	action	action	NN
cord-295807-68sukdb1	322	8	of	of	IN
cord-295807-68sukdb1	322	9	the	the	DT
cord-295807-68sukdb1	322	10	acidloading	acidloade	VBG
cord-295807-68sukdb1	322	11	anion	anion	NN
cord-295807-68sukdb1	322	12	exchange	exchange	NN
cord-295807-68sukdb1	322	13	AE3	AE3	NNS
cord-295807-68sukdb1	322	14	is	be	VBZ
cord-295807-68sukdb1	322	15	considered	consider	VBN
cord-295807-68sukdb1	322	16	to	to	TO
cord-295807-68sukdb1	322	17	be	be	VB
cord-295807-68sukdb1	322	18	protective	protective	JJ
cord-295807-68sukdb1	322	19	against	against	IN
cord-295807-68sukdb1	322	20	hypertrophy	hypertrophy	NN
cord-295807-68sukdb1	322	21	[	[	-LRB-
cord-295807-68sukdb1	322	22	175	175	CD
cord-295807-68sukdb1	322	23	]	]	-RRB-
cord-295807-68sukdb1	322	24	.	.	.
cord-295807-68sukdb1	323	1	Finally	finally	RB
cord-295807-68sukdb1	323	2	,	,	,
cord-295807-68sukdb1	323	3	NHE1	NHE1	NNP
cord-295807-68sukdb1	323	4	action	action	NN
cord-295807-68sukdb1	323	5	in	in	IN
cord-295807-68sukdb1	323	6	the	the	DT
cord-295807-68sukdb1	323	7	mitochondria	mitochondria	NN
cord-295807-68sukdb1	323	8	is	be	VBZ
cord-295807-68sukdb1	323	9	proposed	propose	VBN
cord-295807-68sukdb1	323	10	to	to	TO
cord-295807-68sukdb1	323	11	contribute	contribute	VB
cord-295807-68sukdb1	323	12	to	to	IN
cord-295807-68sukdb1	323	13	mitochondrial	mitochondrial	JJ
cord-295807-68sukdb1	323	14	damage	damage	NN
cord-295807-68sukdb1	323	15	in	in	IN
cord-295807-68sukdb1	323	16	the	the	DT
cord-295807-68sukdb1	323	17	diseased	diseased	JJ
cord-295807-68sukdb1	323	18	heart	heart	NN
cord-295807-68sukdb1	323	19	[	[	-LRB-
cord-295807-68sukdb1	323	20	176	176	CD
cord-295807-68sukdb1	323	21	]	]	-RRB-
cord-295807-68sukdb1	323	22	.	.	.
cord-295807-68sukdb1	324	1	Vasculature	Vasculature	NNP
cord-295807-68sukdb1	324	2	.	.	.
cord-295807-68sukdb1	325	1	Typically	typically	RB
cord-295807-68sukdb1	325	2	,	,	,
cord-295807-68sukdb1	325	3	acidosis	acidosis	NN
cord-295807-68sukdb1	325	4	causes	cause	VBZ
cord-295807-68sukdb1	325	5	arterial	arterial	JJ
cord-295807-68sukdb1	325	6	vessels	vessel	NNS
cord-295807-68sukdb1	325	7	to	to	TO
cord-295807-68sukdb1	325	8	dilate	dilate	VB
cord-295807-68sukdb1	325	9	resulting	result	VBG
cord-295807-68sukdb1	325	10	in	in	IN
cord-295807-68sukdb1	325	11	a	a	DT
cord-295807-68sukdb1	325	12	fall	fall	NN
cord-295807-68sukdb1	325	13	in	in	IN
cord-295807-68sukdb1	325	14	peripheral	peripheral	JJ
cord-295807-68sukdb1	325	15	resistance	resistance	NN
cord-295807-68sukdb1	325	16	,	,	,
cord-295807-68sukdb1	325	17	while	while	IN
cord-295807-68sukdb1	325	18	veins	vein	NNS
cord-295807-68sukdb1	325	19	may	may	MD
cord-295807-68sukdb1	325	20	constrict	constrict	VB
cord-295807-68sukdb1	325	21	[	[	-LRB-
cord-295807-68sukdb1	325	22	169	169	CD
cord-295807-68sukdb1	325	23	]	]	-RRB-
cord-295807-68sukdb1	325	24	.	.	.
cord-295807-68sukdb1	326	1	It	-PRON-	PRP
cord-295807-68sukdb1	326	2	is	be	VBZ
cord-295807-68sukdb1	326	3	perhaps	perhaps	RB
cord-295807-68sukdb1	326	4	then	then	RB
cord-295807-68sukdb1	326	5	no	no	DT
cord-295807-68sukdb1	326	6	surprise	surprise	NN
cord-295807-68sukdb1	326	7	that	that	IN
cord-295807-68sukdb1	326	8	numerous	numerous	JJ
cord-295807-68sukdb1	326	9	blood	blood	NN
cord-295807-68sukdb1	326	10	pressure	pressure	NN
cord-295807-68sukdb1	326	11	traits	trait	NNS
cord-295807-68sukdb1	326	12	are	be	VBP
cord-295807-68sukdb1	326	13	linked	link	VBN
cord-295807-68sukdb1	326	14	to	to	IN
cord-295807-68sukdb1	326	15	polymorphisms	polymorphism	NNS
cord-295807-68sukdb1	326	16	in	in	IN
cord-295807-68sukdb1	326	17	ABT	ABT	NNP
cord-295807-68sukdb1	326	18	genes	gene	NNS
cord-295807-68sukdb1	326	19	[	[	-LRB-
cord-295807-68sukdb1	326	20	177	177	CD
cord-295807-68sukdb1	326	21	]	]	-RRB-
cord-295807-68sukdb1	326	22	.	.	.
cord-295807-68sukdb1	327	1	At	at	RB
cord-295807-68sukdb1	327	2	least	least	JJS
cord-295807-68sukdb1	327	3	at	at	IN
cord-295807-68sukdb1	327	4	the	the	DT
cord-295807-68sukdb1	327	5	level	level	NN
cord-295807-68sukdb1	327	6	of	of	IN
cord-295807-68sukdb1	327	7	the	the	DT
cord-295807-68sukdb1	327	8	vascular	vascular	JJ
cord-295807-68sukdb1	327	9	response	response	NN
cord-295807-68sukdb1	327	10	of	of	IN
cord-295807-68sukdb1	327	11	arteries	artery	NNS
cord-295807-68sukdb1	327	12	,	,	,
cord-295807-68sukdb1	327	13	NBCs	nbc	NNS
cord-295807-68sukdb1	327	14	and	and	CC
cord-295807-68sukdb1	327	15	NHEs	nhe	NNS
cord-295807-68sukdb1	327	16	are	be	VBP
cord-295807-68sukdb1	327	17	required	require	VBN
cord-295807-68sukdb1	327	18	for	for	IN
cord-295807-68sukdb1	327	19	normal	normal	JJ
cord-295807-68sukdb1	327	20	vascular	vascular	JJ
cord-295807-68sukdb1	327	21	smooth	smooth	JJ
cord-295807-68sukdb1	327	22	muscle	muscle	NN
cord-295807-68sukdb1	327	23	contractility	contractility	NN
cord-295807-68sukdb1	327	24	and	and	CC
cord-295807-68sukdb1	327	25	sensitivity	sensitivity	NN
cord-295807-68sukdb1	327	26	to	to	IN
cord-295807-68sukdb1	327	27	vasodilators	vasodilator	NNS
cord-295807-68sukdb1	327	28	[	[	-LRB-
cord-295807-68sukdb1	327	29	177	177	CD
cord-295807-68sukdb1	327	30	]	]	-RRB-
cord-295807-68sukdb1	327	31	.	.	.
cord-295807-68sukdb1	328	1	However	however	RB
cord-295807-68sukdb1	328	2	,	,	,
cord-295807-68sukdb1	328	3	blood	blood	NN
cord-295807-68sukdb1	328	4	pressure	pressure	NN
cord-295807-68sukdb1	328	5	is	be	VBZ
cord-295807-68sukdb1	328	6	a	a	DT
cord-295807-68sukdb1	328	7	complex	complex	JJ
cord-295807-68sukdb1	328	8	trait	trait	NN
cord-295807-68sukdb1	328	9	that	that	WDT
cord-295807-68sukdb1	328	10	is	be	VBZ
cord-295807-68sukdb1	328	11	not	not	RB
cord-295807-68sukdb1	328	12	determined	determine	VBN
cord-295807-68sukdb1	328	13	by	by	IN
cord-295807-68sukdb1	328	14	vascular	vascular	JJ
cord-295807-68sukdb1	328	15	response	response	NN
cord-295807-68sukdb1	328	16	alone	alone	RB
cord-295807-68sukdb1	328	17	,	,	,
cord-295807-68sukdb1	328	18	so	so	CC
cord-295807-68sukdb1	328	19	explanation	explanation	NN
cord-295807-68sukdb1	328	20	of	of	IN
cord-295807-68sukdb1	328	21	these	these	DT
cord-295807-68sukdb1	328	22	linkages	linkage	NNS
cord-295807-68sukdb1	328	23	is	be	VBZ
cord-295807-68sukdb1	328	24	not	not	RB
cord-295807-68sukdb1	328	25	simple	simple	JJ
cord-295807-68sukdb1	328	26	.	.	.
cord-295807-68sukdb1	329	1	Another	another	DT
cord-295807-68sukdb1	329	2	important	important	JJ
cord-295807-68sukdb1	329	3	aspect	aspect	NN
cord-295807-68sukdb1	329	4	is	be	VBZ
cord-295807-68sukdb1	329	5	that	that	IN
cord-295807-68sukdb1	329	6	MAc	MAc	NNP
cord-295807-68sukdb1	329	7	inhibits	inhibit	VBZ
cord-295807-68sukdb1	329	8	progression	progression	NN
cord-295807-68sukdb1	329	9	of	of	IN
cord-295807-68sukdb1	329	10	vascular	vascular	JJ
cord-295807-68sukdb1	329	11	calcification	calcification	NN
cord-295807-68sukdb1	329	12	[	[	-LRB-
cord-295807-68sukdb1	329	13	178	178	CD
cord-295807-68sukdb1	329	14	]	]	-RRB-
cord-295807-68sukdb1	329	15	.	.	.
cord-295807-68sukdb1	330	1	The	the	DT
cord-295807-68sukdb1	330	2	Bohr	Bohr	NNP
cord-295807-68sukdb1	330	3	effect	effect	NN
cord-295807-68sukdb1	330	4	describes	describe	VBZ
cord-295807-68sukdb1	330	5	the	the	DT
cord-295807-68sukdb1	330	6	influence	influence	NN
cord-295807-68sukdb1	330	7	of	of	IN
cord-295807-68sukdb1	330	8	pH	pH	NNP
cord-295807-68sukdb1	330	9	and	and	CC
cord-295807-68sukdb1	330	10	pCO2	pCO2	NNP
cord-295807-68sukdb1	330	11	upon	upon	IN
cord-295807-68sukdb1	330	12	the	the	DT
cord-295807-68sukdb1	330	13	oxygen	oxygen	NN
cord-295807-68sukdb1	330	14	carrying	carrying	NN
cord-295807-68sukdb1	330	15	capacity	capacity	NN
cord-295807-68sukdb1	330	16	of	of	IN
cord-295807-68sukdb1	330	17	hemoglobin	hemoglobin	NN
cord-295807-68sukdb1	330	18	.	.	.
cord-295807-68sukdb1	331	1	In	in	IN
cord-295807-68sukdb1	331	2	systemic	systemic	JJ
cord-295807-68sukdb1	331	3	capillaries	capillary	NNS
cord-295807-68sukdb1	331	4	,	,	,
cord-295807-68sukdb1	331	5	metabolically	metabolically	RB
cord-295807-68sukdb1	331	6	produced	produce	VBD
cord-295807-68sukdb1	331	7	CO2	CO2	NNP
cord-295807-68sukdb1	331	8	enters	enter	VBZ
cord-295807-68sukdb1	331	9	the	the	DT
cord-295807-68sukdb1	331	10	red	red	JJ
cord-295807-68sukdb1	331	11	blood	blood	NN
cord-295807-68sukdb1	331	12	cells	cell	NNS
cord-295807-68sukdb1	331	13	(	(	-LRB-
cord-295807-68sukdb1	331	14	RBCs	rbc	NNS
cord-295807-68sukdb1	331	15	)	)	-RRB-
cord-295807-68sukdb1	331	16	where	where	WRB
cord-295807-68sukdb1	331	17	it	-PRON-	PRP
cord-295807-68sukdb1	331	18	is	be	VBZ
cord-295807-68sukdb1	331	19	hydrolyzed	hydrolyze	VBN
cord-295807-68sukdb1	331	20	into	into	IN
cord-295807-68sukdb1	331	21	HCO3and	hco3and	CC
cord-295807-68sukdb1	331	22	H	h	NN
cord-295807-68sukdb1	331	23	+	+	SYM
cord-295807-68sukdb1	331	24	by	by	IN
cord-295807-68sukdb1	331	25	the	the	DT
cord-295807-68sukdb1	331	26	action	action	NN
cord-295807-68sukdb1	331	27	of	of	IN
cord-295807-68sukdb1	331	28	CAII	CAII	NNP
cord-295807-68sukdb1	331	29	.	.	.
cord-295807-68sukdb1	332	1	The	the	DT
cord-295807-68sukdb1	332	2	newly	newly	RB
cord-295807-68sukdb1	332	3	produced	produce	VBN
cord-295807-68sukdb1	332	4	HCO3is	HCO3is	NNP
cord-295807-68sukdb1	332	5	then	then	RB
cord-295807-68sukdb1	332	6	extruded	extrude	VBN
cord-295807-68sukdb1	332	7	by	by	IN
cord-295807-68sukdb1	332	8	AE1	AE1	NNP
cord-295807-68sukdb1	332	9	,	,	,
cord-295807-68sukdb1	332	10	causing	cause	VBG
cord-295807-68sukdb1	332	11	a	a	DT
cord-295807-68sukdb1	332	12	fall	fall	NN
cord-295807-68sukdb1	332	13	in	in	IN
cord-295807-68sukdb1	332	14	RBC	RBC	NNP
cord-295807-68sukdb1	332	15	pHi	pHi	NNS
cord-295807-68sukdb1	332	16	which	which	WDT
cord-295807-68sukdb1	332	17	,	,	,
cord-295807-68sukdb1	332	18	by	by	IN
cord-295807-68sukdb1	332	19	the	the	DT
cord-295807-68sukdb1	332	20	Bohr	Bohr	NNP
cord-295807-68sukdb1	332	21	effect	effect	NN
cord-295807-68sukdb1	332	22	,	,	,
cord-295807-68sukdb1	332	23	reduces	reduce	VBZ
cord-295807-68sukdb1	332	24	the	the	DT
cord-295807-68sukdb1	332	25	Hb	Hb	NNP
cord-295807-68sukdb1	332	26	-	-	HYPH
cord-295807-68sukdb1	332	27	O2	O2	NNP
cord-295807-68sukdb1	332	28	binding	binding	NN
cord-295807-68sukdb1	332	29	affinity	affinity	NN
cord-295807-68sukdb1	332	30	,	,	,
cord-295807-68sukdb1	332	31	promoting	promote	VBG
cord-295807-68sukdb1	332	32	O2	o2	NN
cord-295807-68sukdb1	332	33	release	release	NN
cord-295807-68sukdb1	332	34	from	from	IN
cord-295807-68sukdb1	332	35	Hb	Hb	NNP
cord-295807-68sukdb1	332	36	to	to	TO
cord-295807-68sukdb1	332	37	tissue	tissue	NN
cord-295807-68sukdb1	332	38	(	(	-LRB-
cord-295807-68sukdb1	332	39	Figure	figure	NN
cord-295807-68sukdb1	332	40	7B	7b	NN
cord-295807-68sukdb1	332	41	)	)	-RRB-
cord-295807-68sukdb1	332	42	.	.	.
cord-295807-68sukdb1	333	1	The	the	DT
cord-295807-68sukdb1	333	2	reverse	reverse	JJ
cord-295807-68sukdb1	333	3	process	process	NN
cord-295807-68sukdb1	333	4	occurs	occur	VBZ
cord-295807-68sukdb1	333	5	in	in	IN
cord-295807-68sukdb1	333	6	the	the	DT
cord-295807-68sukdb1	333	7	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	333	8	capillaries	capillary	NNS
cord-295807-68sukdb1	333	9	.	.	.
cord-295807-68sukdb1	334	1	Here	here	RB
cord-295807-68sukdb1	334	2	,	,	,
cord-295807-68sukdb1	334	3	as	as	IN
cord-295807-68sukdb1	334	4	CO2	CO2	NNP
cord-295807-68sukdb1	334	5	leaves	leave	VBZ
cord-295807-68sukdb1	334	6	RBC	RBC	NNP
cord-295807-68sukdb1	334	7	pHi	pHi	NNS
cord-295807-68sukdb1	334	8	rises	rise	VBZ
cord-295807-68sukdb1	334	9	thereby	thereby	RB
cord-295807-68sukdb1	334	10	favoring	favor	VBG
cord-295807-68sukdb1	334	11	O2	o2	NN
cord-295807-68sukdb1	334	12	binding	binding	NN
cord-295807-68sukdb1	334	13	to	to	IN
cord-295807-68sukdb1	334	14	Hb	Hb	NNP
cord-295807-68sukdb1	334	15	(	(	-LRB-
cord-295807-68sukdb1	334	16	Figure	figure	NN
cord-295807-68sukdb1	334	17	7B	7b	NN
cord-295807-68sukdb1	334	18	)	)	-RRB-
cord-295807-68sukdb1	334	19	.	.	.
cord-295807-68sukdb1	335	1	Thus	thus	RB
cord-295807-68sukdb1	335	2	acidosis	acidosis	NN
cord-295807-68sukdb1	335	3	enhances	enhance	VBZ
cord-295807-68sukdb1	335	4	O2	o2	NN
cord-295807-68sukdb1	335	5	delivery	delivery	NN
cord-295807-68sukdb1	335	6	into	into	IN
cord-295807-68sukdb1	335	7	tissues	tissue	NNS
cord-295807-68sukdb1	335	8	,	,	,
cord-295807-68sukdb1	335	9	but	but	CC
cord-295807-68sukdb1	335	10	diminishes	diminish	VBZ
cord-295807-68sukdb1	335	11	O2	O2	NNP
cord-295807-68sukdb1	335	12	loading	loading	NN
cord-295807-68sukdb1	335	13	in	in	IN
cord-295807-68sukdb1	335	14	the	the	DT
cord-295807-68sukdb1	335	15	lungs	lung	NNS
cord-295807-68sukdb1	335	16	[	[	-LRB-
cord-295807-68sukdb1	335	17	169	169	CD
cord-295807-68sukdb1	335	18	]	]	-RRB-
cord-295807-68sukdb1	335	19	.	.	.
cord-295807-68sukdb1	336	1	This	this	DT
cord-295807-68sukdb1	336	2	relationship	relationship	NN
cord-295807-68sukdb1	336	3	between	between	IN
cord-295807-68sukdb1	336	4	pH	pH	NNP
cord-295807-68sukdb1	336	5	and	and	CC
cord-295807-68sukdb1	336	6	gas	gas	NN
cord-295807-68sukdb1	336	7	exchange	exchange	NN
cord-295807-68sukdb1	336	8	is	be	VBZ
cord-295807-68sukdb1	336	9	partly	partly	RB
cord-295807-68sukdb1	336	10	sensitized	sensitize	VBN
cord-295807-68sukdb1	336	11	by	by	IN
cord-295807-68sukdb1	336	12	the	the	DT
cord-295807-68sukdb1	336	13	content	content	NN
cord-295807-68sukdb1	336	14	of	of	IN
cord-295807-68sukdb1	336	15	the	the	DT
cord-295807-68sukdb1	336	16	hemoglobin	hemoglobin	NN
cord-295807-68sukdb1	336	17	-	-	HYPH
cord-295807-68sukdb1	336	18	regulating	regulate	VBG
cord-295807-68sukdb1	336	19	molecule	molecule	NN
cord-295807-68sukdb1	336	20	2,3-DPG	2,3-dpg	CD
cord-295807-68sukdb1	336	21	(	(	-LRB-
cord-295807-68sukdb1	336	22	diphosphoglyceric	diphosphoglyceric	NNP
cord-295807-68sukdb1	336	23	acid	acid	NN
cord-295807-68sukdb1	336	24	)	)	-RRB-
cord-295807-68sukdb1	336	25	in	in	IN
cord-295807-68sukdb1	336	26	RBCs	rbc	NNS
cord-295807-68sukdb1	336	27	,	,	,
cord-295807-68sukdb1	336	28	a	a	DT
cord-295807-68sukdb1	336	29	parameter	parameter	NN
cord-295807-68sukdb1	336	30	which	which	WDT
cord-295807-68sukdb1	336	31	itself	-PRON-	PRP
cord-295807-68sukdb1	336	32	is	be	VBZ
cord-295807-68sukdb1	336	33	pH	ph	NN
cord-295807-68sukdb1	336	34	-	-	HYPH
cord-295807-68sukdb1	336	35	dependent	dependent	JJ
cord-295807-68sukdb1	336	36	;	;	:
cord-295807-68sukdb1	336	37	2,3-DPG	2,3-dpg	CD
cord-295807-68sukdb1	336	38	levels	level	NNS
cord-295807-68sukdb1	336	39	increase	increase	VBP
cord-295807-68sukdb1	336	40	with	with	IN
cord-295807-68sukdb1	336	41	chronic	chronic	JJ
cord-295807-68sukdb1	336	42	acidosis	acidosis	NN
cord-295807-68sukdb1	336	43	promoting	promote	VBG
cord-295807-68sukdb1	336	44	O2	o2	NN
cord-295807-68sukdb1	336	45	release	release	NN
cord-295807-68sukdb1	336	46	[	[	-LRB-
cord-295807-68sukdb1	336	47	179	179	CD
cord-295807-68sukdb1	336	48	]	]	-RRB-
cord-295807-68sukdb1	336	49	.	.	.
cord-295807-68sukdb1	337	1	Heart	heart	NN
cord-295807-68sukdb1	337	2	.	.	.
cord-295807-68sukdb1	338	1	Exogenous	exogenous	JJ
cord-295807-68sukdb1	338	2	expression	expression	NN
cord-295807-68sukdb1	338	3	of	of	IN
cord-295807-68sukdb1	338	4	skeletal	skeletal	JJ
cord-295807-68sukdb1	338	5	muscle	muscle	NN
cord-295807-68sukdb1	338	6	CAIII	CAIII	NNP
cord-295807-68sukdb1	338	7	in	in	IN
cord-295807-68sukdb1	338	8	mouse	mouse	NN
cord-295807-68sukdb1	338	9	cardiomyocytes	cardiomyocyte	NNS
cord-295807-68sukdb1	338	10	enhances	enhance	VBZ
cord-295807-68sukdb1	338	11	defense	defense	NN
cord-295807-68sukdb1	338	12	of	of	IN
cord-295807-68sukdb1	338	13	pHi	pHi	NNS
cord-295807-68sukdb1	338	14	and	and	CC
cord-295807-68sukdb1	338	15	preserves	preserve	VBZ
cord-295807-68sukdb1	338	16	cardiac	cardiac	JJ
cord-295807-68sukdb1	338	17	function	function	NN
cord-295807-68sukdb1	338	18	during	during	IN
cord-295807-68sukdb1	338	19	MAc	MAc	NNP
cord-295807-68sukdb1	338	20	[	[	-LRB-
cord-295807-68sukdb1	338	21	180	180	CD
cord-295807-68sukdb1	338	22	]	]	-RRB-
cord-295807-68sukdb1	338	23	.	.	.
cord-295807-68sukdb1	339	1	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	339	2	is	be	VBZ
cord-295807-68sukdb1	339	3	used	use	VBN
cord-295807-68sukdb1	339	4	to	to	TO
cord-295807-68sukdb1	339	5	counter	counter	VB
cord-295807-68sukdb1	339	6	lactic	lactic	JJ
cord-295807-68sukdb1	339	7	acidosis	acidosis	NN
cord-295807-68sukdb1	339	8	in	in	IN
cord-295807-68sukdb1	339	9	cardiac	cardiac	JJ
cord-295807-68sukdb1	339	10	arrest	arrest	NN
cord-295807-68sukdb1	339	11	and	and	CC
cord-295807-68sukdb1	339	12	during	during	IN
cord-295807-68sukdb1	339	13	prolonged	prolonged	JJ
cord-295807-68sukdb1	339	14	cardiopulmonary	cardiopulmonary	JJ
cord-295807-68sukdb1	339	15	resuscitation	resuscitation	NN
cord-295807-68sukdb1	339	16	,	,	,
cord-295807-68sukdb1	339	17	but	but	CC
cord-295807-68sukdb1	339	18	aside	aside	RB
cord-295807-68sukdb1	339	19	from	from	IN
cord-295807-68sukdb1	339	20	its	-PRON-	PRP$
cord-295807-68sukdb1	339	21	value	value	NN
cord-295807-68sukdb1	339	22	at	at	IN
cord-295807-68sukdb1	339	23	normalizing	normalize	VBG
cord-295807-68sukdb1	339	24	pre	pre	JJ
cord-295807-68sukdb1	339	25	-	-	JJ
cord-295807-68sukdb1	339	26	existing	existing	JJ
cord-295807-68sukdb1	339	27	MAc	MAc	NNP
cord-295807-68sukdb1	339	28	or	or	CC
cord-295807-68sukdb1	339	29	hyperkalemia	hyperkalemia	NN
cord-295807-68sukdb1	339	30	(	(	-LRB-
cord-295807-68sukdb1	339	31	acidosis	acidosis	NN
cord-295807-68sukdb1	339	32	promotes	promote	VBZ
cord-295807-68sukdb1	339	33	cellular	cellular	JJ
cord-295807-68sukdb1	339	34	K	k	NN
cord-295807-68sukdb1	339	35	+	+	CC
cord-295807-68sukdb1	339	36	release	release	NN
cord-295807-68sukdb1	339	37	)	)	-RRB-
cord-295807-68sukdb1	339	38	,	,	,
cord-295807-68sukdb1	339	39	compelling	compelling	JJ
cord-295807-68sukdb1	339	40	data	datum	NNS
cord-295807-68sukdb1	339	41	that	that	IN
cord-295807-68sukdb1	339	42	this	this	DT
cord-295807-68sukdb1	339	43	treatment	treatment	NN
cord-295807-68sukdb1	339	44	improves	improve	VBZ
cord-295807-68sukdb1	339	45	outcomes	outcome	NNS
cord-295807-68sukdb1	339	46	are	be	VBP
cord-295807-68sukdb1	339	47	lacking	lack	VBG
cord-295807-68sukdb1	339	48	[	[	-LRB-
cord-295807-68sukdb1	339	49	181	181	CD
cord-295807-68sukdb1	339	50	]	]	-RRB-
cord-295807-68sukdb1	339	51	[	[	-LRB-
cord-295807-68sukdb1	339	52	182	182	CD
cord-295807-68sukdb1	339	53	]	]	-RRB-
cord-295807-68sukdb1	339	54	[	[	-LRB-
cord-295807-68sukdb1	339	55	183	183	CD
cord-295807-68sukdb1	339	56	]	]	-RRB-
cord-295807-68sukdb1	339	57	.	.	.
cord-295807-68sukdb1	340	1	NHE1	NHE1	NNP
cord-295807-68sukdb1	340	2	blockers	blocker	NNS
cord-295807-68sukdb1	340	3	have	have	VBP
cord-295807-68sukdb1	340	4	shown	show	VBN
cord-295807-68sukdb1	340	5	promise	promise	NN
cord-295807-68sukdb1	340	6	as	as	IN
cord-295807-68sukdb1	340	7	cardioprotective	cardioprotective	JJ
cord-295807-68sukdb1	340	8	agents	agent	NNS
cord-295807-68sukdb1	340	9	in	in	IN
cord-295807-68sukdb1	340	10	reperfusion	reperfusion	NN
cord-295807-68sukdb1	340	11	injury	injury	NN
cord-295807-68sukdb1	340	12	[	[	-LRB-
cord-295807-68sukdb1	340	13	184	184	CD
cord-295807-68sukdb1	340	14	]	]	-RRB-
cord-295807-68sukdb1	340	15	and	and	CC
cord-295807-68sukdb1	340	16	likely	likely	RB
cord-295807-68sukdb1	340	17	act	act	VB
cord-295807-68sukdb1	340	18	by	by	IN
cord-295807-68sukdb1	340	19	targeting	target	VBG
cord-295807-68sukdb1	340	20	both	both	DT
cord-295807-68sukdb1	340	21	plasma	plasma	NN
cord-295807-68sukdb1	340	22	membrane	membrane	NN
cord-295807-68sukdb1	340	23	and	and	CC
cord-295807-68sukdb1	340	24	mitochondrial	mitochondrial	JJ
cord-295807-68sukdb1	340	25	NHE1	NHE1	NNP
cord-295807-68sukdb1	340	26	[	[	-LRB-
cord-295807-68sukdb1	340	27	185	185	CD
cord-295807-68sukdb1	340	28	,	,	,
cord-295807-68sukdb1	340	29	186	186	CD
cord-295807-68sukdb1	340	30	]	]	-RRB-
cord-295807-68sukdb1	340	31	.	.	.
cord-295807-68sukdb1	341	1	Although	although	IN
cord-295807-68sukdb1	341	2	the	the	DT
cord-295807-68sukdb1	341	3	NHE1	NHE1	NNP
cord-295807-68sukdb1	341	4	blocker	blocker	NN
cord-295807-68sukdb1	341	5	cariporide	cariporide	NN
cord-295807-68sukdb1	341	6	caused	cause	VBD
cord-295807-68sukdb1	341	7	serious	serious	JJ
cord-295807-68sukdb1	341	8	side	side	NN
cord-295807-68sukdb1	341	9	-	-	HYPH
cord-295807-68sukdb1	341	10	effects	effect	NNS
cord-295807-68sukdb1	341	11	in	in	IN
cord-295807-68sukdb1	341	12	clinical	clinical	JJ
cord-295807-68sukdb1	341	13	trials	trial	NNS
cord-295807-68sukdb1	341	14	(	(	-LRB-
cord-295807-68sukdb1	341	15	see	see	VB
cord-295807-68sukdb1	341	16	section	section	NN
cord-295807-68sukdb1	341	17	2.2.2	2.2.2	CD
cord-295807-68sukdb1	341	18	)	)	-RRB-
cord-295807-68sukdb1	341	19	,	,	,
cord-295807-68sukdb1	341	20	alternative	alternative	JJ
cord-295807-68sukdb1	341	21	approaches	approach	NNS
cord-295807-68sukdb1	341	22	are	be	VBP
cord-295807-68sukdb1	341	23	available	available	JJ
cord-295807-68sukdb1	341	24	.	.	.
cord-295807-68sukdb1	342	1	For	for	IN
cord-295807-68sukdb1	342	2	example	example	NN
cord-295807-68sukdb1	342	3	,	,	,
cord-295807-68sukdb1	342	4	a	a	DT
cord-295807-68sukdb1	342	5	microRNA	microrna	NN
cord-295807-68sukdb1	342	6	that	that	WDT
cord-295807-68sukdb1	342	7	lowers	lower	VBZ
cord-295807-68sukdb1	342	8	NHE1	NHE1	NNP
cord-295807-68sukdb1	342	9	expression	expression	NN
cord-295807-68sukdb1	342	10	protects	protect	VBZ
cord-295807-68sukdb1	342	11	cardiomyocytes	cardiomyocyte	NNS
cord-295807-68sukdb1	342	12	from	from	IN
cord-295807-68sukdb1	342	13	apoptosis	apoptosis	NN
cord-295807-68sukdb1	342	14	during	during	IN
cord-295807-68sukdb1	342	15	prolonged	prolong	VBN
cord-295807-68sukdb1	342	16	endoplasmic	endoplasmic	NN
cord-295807-68sukdb1	342	17	reticulum	reticulum	NN
cord-295807-68sukdb1	342	18	stress	stress	NN
cord-295807-68sukdb1	342	19	[	[	-LRB-
cord-295807-68sukdb1	342	20	187	187	CD
cord-295807-68sukdb1	342	21	]	]	-RRB-
cord-295807-68sukdb1	342	22	.	.	.
cord-295807-68sukdb1	343	1	In	in	IN
cord-295807-68sukdb1	343	2	addition	addition	NN
cord-295807-68sukdb1	343	3	,	,	,
cord-295807-68sukdb1	343	4	antibodies	antibody	NNS
cord-295807-68sukdb1	343	5	and	and	CC
cord-295807-68sukdb1	343	6	drugs	drug	NNS
cord-295807-68sukdb1	343	7	that	that	WDT
cord-295807-68sukdb1	343	8	block	block	VBP
cord-295807-68sukdb1	343	9	NBCs	nbc	NNS
cord-295807-68sukdb1	343	10	have	have	VBP
cord-295807-68sukdb1	343	11	also	also	RB
cord-295807-68sukdb1	343	12	demonstrated	demonstrate	VBN
cord-295807-68sukdb1	343	13	cardioprotective	cardioprotective	JJ
cord-295807-68sukdb1	343	14	properties	property	NNS
cord-295807-68sukdb1	343	15	in	in	IN
cord-295807-68sukdb1	343	16	animal	animal	NN
cord-295807-68sukdb1	343	17	models	model	NNS
cord-295807-68sukdb1	343	18	of	of	IN
cord-295807-68sukdb1	343	19	ischemia	ischemia	NN
cord-295807-68sukdb1	343	20	reperfusion	reperfusion	NN
cord-295807-68sukdb1	343	21	injury	injury	NN
cord-295807-68sukdb1	343	22	[	[	-LRB-
cord-295807-68sukdb1	343	23	188	188	CD
cord-295807-68sukdb1	343	24	,	,	,
cord-295807-68sukdb1	343	25	189	189	CD
cord-295807-68sukdb1	343	26	]	]	-RRB-
cord-295807-68sukdb1	343	27	.	.	.
cord-295807-68sukdb1	344	1	Just	just	RB
cord-295807-68sukdb1	344	2	as	as	IN
cord-295807-68sukdb1	344	3	blockade	blockade	NN
cord-295807-68sukdb1	344	4	of	of	IN
cord-295807-68sukdb1	344	5	acid	acid	NN
cord-295807-68sukdb1	344	6	-	-	HYPH
cord-295807-68sukdb1	344	7	extruders	extruder	NNS
cord-295807-68sukdb1	344	8	is	be	VBZ
cord-295807-68sukdb1	344	9	cardioprotective	cardioprotective	JJ
cord-295807-68sukdb1	344	10	,	,	,
cord-295807-68sukdb1	344	11	so	so	RB
cord-295807-68sukdb1	344	12	too	too	RB
cord-295807-68sukdb1	344	13	is	be	VBZ
cord-295807-68sukdb1	344	14	the	the	DT
cord-295807-68sukdb1	344	15	stimulation	stimulation	NN
cord-295807-68sukdb1	344	16	of	of	IN
cord-295807-68sukdb1	344	17	the	the	DT
cord-295807-68sukdb1	344	18	acid	acid	NN
cord-295807-68sukdb1	344	19	loader	loader	NN
cord-295807-68sukdb1	344	20	AE3	AE3	NNS
cord-295807-68sukdb1	344	21	.	.	.
cord-295807-68sukdb1	345	1	This	this	DT
cord-295807-68sukdb1	345	2	has	have	VBZ
cord-295807-68sukdb1	345	3	been	be	VBN
cord-295807-68sukdb1	345	4	achieved	achieve	VBN
cord-295807-68sukdb1	345	5	in	in	IN
cord-295807-68sukdb1	345	6	cell	cell	NN
cord-295807-68sukdb1	345	7	models	model	NNS
cord-295807-68sukdb1	345	8	using	use	VBG
cord-295807-68sukdb1	345	9	the	the	DT
cord-295807-68sukdb1	345	10	glycoside	glycoside	NN
cord-295807-68sukdb1	345	11	sasanqua	sasanqua	JJ
cord-295807-68sukdb1	345	12	saponin	saponin	NN
cord-295807-68sukdb1	345	13	[	[	-LRB-
cord-295807-68sukdb1	345	14	190	190	CD
cord-295807-68sukdb1	345	15	]	]	-RRB-
cord-295807-68sukdb1	345	16	,	,	,
cord-295807-68sukdb1	345	17	an	an	DT
cord-295807-68sukdb1	345	18	extract	extract	NN
cord-295807-68sukdb1	345	19	from	from	IN
cord-295807-68sukdb1	345	20	a	a	DT
cord-295807-68sukdb1	345	21	herb	herb	NN
cord-295807-68sukdb1	345	22	used	use	VBN
cord-295807-68sukdb1	345	23	in	in	IN
cord-295807-68sukdb1	345	24	traditional	traditional	JJ
cord-295807-68sukdb1	345	25	Chinese	chinese	JJ
cord-295807-68sukdb1	345	26	medicine	medicine	NN
cord-295807-68sukdb1	345	27	.	.	.
cord-295807-68sukdb1	346	1	We	-PRON-	PRP
cord-295807-68sukdb1	346	2	are	be	VBP
cord-295807-68sukdb1	346	3	unaware	unaware	JJ
cord-295807-68sukdb1	346	4	of	of	IN
cord-295807-68sukdb1	346	5	any	any	DT
cord-295807-68sukdb1	346	6	reports	report	NNS
cord-295807-68sukdb1	346	7	of	of	IN
cord-295807-68sukdb1	346	8	acid	acid	NN
cord-295807-68sukdb1	346	9	-	-	HYPH
cord-295807-68sukdb1	346	10	base	base	NN
cord-295807-68sukdb1	346	11	based	base	VBN
cord-295807-68sukdb1	346	12	therapies	therapy	NNS
cord-295807-68sukdb1	346	13	for	for	IN
cord-295807-68sukdb1	346	14	blood	blood	NN
cord-295807-68sukdb1	346	15	pressure	pressure	NN
cord-295807-68sukdb1	346	16	that	that	WDT
cord-295807-68sukdb1	346	17	directly	directly	RB
cord-295807-68sukdb1	346	18	target	target	VBP
cord-295807-68sukdb1	346	19	the	the	DT
cord-295807-68sukdb1	346	20	vasculature	vasculature	NN
cord-295807-68sukdb1	346	21	,	,	,
cord-295807-68sukdb1	346	22	but	but	CC
cord-295807-68sukdb1	346	23	a	a	DT
cord-295807-68sukdb1	346	24	discussion	discussion	NN
cord-295807-68sukdb1	346	25	of	of	IN
cord-295807-68sukdb1	346	26	diuretics	diuretic	NNS
cord-295807-68sukdb1	346	27	for	for	IN
cord-295807-68sukdb1	346	28	lowering	lower	VBG
cord-295807-68sukdb1	346	29	blood	blood	NN
cord-295807-68sukdb1	346	30	pressure	pressure	NN
cord-295807-68sukdb1	346	31	in	in	IN
cord-295807-68sukdb1	346	32	congestive	congestive	JJ
cord-295807-68sukdb1	346	33	heart	heart	NN
cord-295807-68sukdb1	346	34	failure	failure	NN
cord-295807-68sukdb1	346	35	is	be	VBZ
cord-295807-68sukdb1	346	36	provided	provide	VBN
cord-295807-68sukdb1	346	37	in	in	IN
cord-295807-68sukdb1	346	38	The	the	DT
cord-295807-68sukdb1	346	39	Urinary	Urinary	NNP
cord-295807-68sukdb1	346	40	System	System	NNP
cord-295807-68sukdb1	346	41	section	section	NN
cord-295807-68sukdb1	346	42	.	.	.
cord-295807-68sukdb1	347	1	Some	some	DT
cord-295807-68sukdb1	347	2	alkali	alkali	RB
cord-295807-68sukdb1	347	3	-	-	HYPH
cord-295807-68sukdb1	347	4	containing	contain	VBG
cord-295807-68sukdb1	347	5	therapies	therapy	NNS
cord-295807-68sukdb1	347	6	may	may	MD
cord-295807-68sukdb1	347	7	enhance	enhance	VB
cord-295807-68sukdb1	347	8	progression	progression	NN
cord-295807-68sukdb1	347	9	of	of	IN
cord-295807-68sukdb1	347	10	vascular	vascular	JJ
cord-295807-68sukdb1	347	11	calcification	calcification	NN
cord-295807-68sukdb1	347	12	[	[	-LRB-
cord-295807-68sukdb1	347	13	191	191	CD
cord-295807-68sukdb1	347	14	]	]	-RRB-
cord-295807-68sukdb1	347	15	while	while	IN
cord-295807-68sukdb1	347	16	use	use	NN
cord-295807-68sukdb1	347	17	of	of	IN
cord-295807-68sukdb1	347	18	the	the	DT
cord-295807-68sukdb1	347	19	CA	CA	NNP
cord-295807-68sukdb1	347	20	blocker	blocker	NN
cord-295807-68sukdb1	347	21	ACZ	ACZ	NNP
cord-295807-68sukdb1	347	22	has	have	VBZ
cord-295807-68sukdb1	347	23	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	347	24	value	value	NN
cord-295807-68sukdb1	347	25	in	in	IN
cord-295807-68sukdb1	347	26	calcifying	calcify	VBG
cord-295807-68sukdb1	347	27	disease	disease	NN
cord-295807-68sukdb1	347	28	[	[	-LRB-
cord-295807-68sukdb1	347	29	178	178	CD
cord-295807-68sukdb1	347	30	,	,	,
cord-295807-68sukdb1	347	31	192	192	CD
cord-295807-68sukdb1	347	32	]	]	-RRB-
cord-295807-68sukdb1	347	33	,	,	,
cord-295807-68sukdb1	347	34	perhaps	perhaps	RB
cord-295807-68sukdb1	347	35	by	by	IN
cord-295807-68sukdb1	347	36	lowering	lower	VBG
cord-295807-68sukdb1	347	37	pH.	pH.	NNP
cord-295807-68sukdb1	347	38	One	one	CD
cord-295807-68sukdb1	347	39	study	study	NN
cord-295807-68sukdb1	347	40	has	have	VBZ
cord-295807-68sukdb1	347	41	cautioned	caution	VBN
cord-295807-68sukdb1	347	42	the	the	DT
cord-295807-68sukdb1	347	43	use	use	NN
cord-295807-68sukdb1	347	44	of	of	IN
cord-295807-68sukdb1	347	45	NaHCO3	nahco3	NN
cord-295807-68sukdb1	347	46	in	in	IN
cord-295807-68sukdb1	347	47	congestive	congestive	JJ
cord-295807-68sukdb1	347	48	heart	heart	NN
cord-295807-68sukdb1	347	49	failure	failure	NN
cord-295807-68sukdb1	347	50	because	because	IN
cord-295807-68sukdb1	347	51	,	,	,
cord-295807-68sukdb1	347	52	in	in	IN
cord-295807-68sukdb1	347	53	the	the	DT
cord-295807-68sukdb1	347	54	face	face	NN
cord-295807-68sukdb1	347	55	of	of	IN
cord-295807-68sukdb1	347	56	adaptively	adaptively	RB
cord-295807-68sukdb1	347	57	elevated	elevate	VBN
cord-295807-68sukdb1	347	58	2,3-DPG	2,3-dpg	CD
cord-295807-68sukdb1	347	59	levels	level	NNS
cord-295807-68sukdb1	347	60	,	,	,
cord-295807-68sukdb1	347	61	a	a	DT
cord-295807-68sukdb1	347	62	sudden	sudden	JJ
cord-295807-68sukdb1	347	63	rise	rise	NN
cord-295807-68sukdb1	347	64	in	in	IN
cord-295807-68sukdb1	347	65	pH	ph	NN
cord-295807-68sukdb1	347	66	could	could	MD
cord-295807-68sukdb1	347	67	result	result	VB
cord-295807-68sukdb1	347	68	in	in	IN
cord-295807-68sukdb1	347	69	a	a	DT
cord-295807-68sukdb1	347	70	maladaptive	maladaptive	JJ
cord-295807-68sukdb1	347	71	increase	increase	NN
cord-295807-68sukdb1	347	72	in	in	IN
cord-295807-68sukdb1	347	73	Hb	Hb	NNP
cord-295807-68sukdb1	347	74	-	-	HYPH
cord-295807-68sukdb1	347	75	O2	O2	NNP
cord-295807-68sukdb1	347	76	affinity	affinity	NN
cord-295807-68sukdb1	347	77	and	and	CC
cord-295807-68sukdb1	347	78	risk	risk	NN
cord-295807-68sukdb1	347	79	of	of	IN
cord-295807-68sukdb1	347	80	myocardial	myocardial	JJ
cord-295807-68sukdb1	347	81	ischemia	ischemia	NN
cord-295807-68sukdb1	347	82	[	[	-LRB-
cord-295807-68sukdb1	347	83	193	193	CD
cord-295807-68sukdb1	347	84	]	]	-RRB-
cord-295807-68sukdb1	347	85	.	.	.
cord-295807-68sukdb1	348	1	In	in	IN
cord-295807-68sukdb1	348	2	skeletal	skeletal	JJ
cord-295807-68sukdb1	348	3	muscles	muscle	NNS
cord-295807-68sukdb1	348	4	,	,	,
cord-295807-68sukdb1	348	5	the	the	DT
cord-295807-68sukdb1	348	6	build	build	NN
cord-295807-68sukdb1	348	7	-	-	HYPH
cord-295807-68sukdb1	348	8	up	up	NN
cord-295807-68sukdb1	348	9	of	of	IN
cord-295807-68sukdb1	348	10	lactic	lactic	JJ
cord-295807-68sukdb1	348	11	acid	acid	NN
cord-295807-68sukdb1	348	12	during	during	IN
cord-295807-68sukdb1	348	13	intense	intense	JJ
cord-295807-68sukdb1	348	14	exercise	exercise	NN
cord-295807-68sukdb1	348	15	correlates	correlate	VBZ
cord-295807-68sukdb1	348	16	with	with	IN
cord-295807-68sukdb1	348	17	muscle	muscle	NN
cord-295807-68sukdb1	348	18	weakness	weakness	NN
cord-295807-68sukdb1	348	19	and	and	CC
cord-295807-68sukdb1	348	20	self	self	NN
cord-295807-68sukdb1	348	21	-	-	HYPH
cord-295807-68sukdb1	348	22	limiting	limit	VBG
cord-295807-68sukdb1	348	23	fatigue	fatigue	NN
cord-295807-68sukdb1	348	24	.	.	.
cord-295807-68sukdb1	349	1	However	however	RB
cord-295807-68sukdb1	349	2	,	,	,
cord-295807-68sukdb1	349	3	the	the	DT
cord-295807-68sukdb1	349	4	contribution	contribution	NN
cord-295807-68sukdb1	349	5	of	of	IN
cord-295807-68sukdb1	349	6	lactic	lactic	JJ
cord-295807-68sukdb1	349	7	acidosis	acidosis	NN
cord-295807-68sukdb1	349	8	to	to	IN
cord-295807-68sukdb1	349	9	those	those	DT
cord-295807-68sukdb1	349	10	symptoms	symptom	NNS
cord-295807-68sukdb1	349	11	may	may	MD
cord-295807-68sukdb1	349	12	not	not	RB
cord-295807-68sukdb1	349	13	be	be	VB
cord-295807-68sukdb1	349	14	as	as	RB
cord-295807-68sukdb1	349	15	direct	direct	JJ
cord-295807-68sukdb1	349	16	or	or	CC
cord-295807-68sukdb1	349	17	major	major	JJ
cord-295807-68sukdb1	349	18	as	as	IN
cord-295807-68sukdb1	349	19	once	once	RB
cord-295807-68sukdb1	349	20	thought	think	VBN
cord-295807-68sukdb1	349	21	[	[	-LRB-
cord-295807-68sukdb1	349	22	194	194	CD
cord-295807-68sukdb1	349	23	,	,	,
cord-295807-68sukdb1	349	24	195	195	CD
cord-295807-68sukdb1	349	25	]	]	-RRB-
cord-295807-68sukdb1	349	26	.	.	.
cord-295807-68sukdb1	350	1	Generalized	generalized	JJ
cord-295807-68sukdb1	350	2	acidosis	acidosis	NN
cord-295807-68sukdb1	350	3	may	may	MD
cord-295807-68sukdb1	350	4	contribute	contribute	VB
cord-295807-68sukdb1	350	5	to	to	IN
cord-295807-68sukdb1	350	6	weakness	weakness	NN
cord-295807-68sukdb1	350	7	via	via	IN
cord-295807-68sukdb1	350	8	alterations	alteration	NNS
cord-295807-68sukdb1	350	9	in	in	IN
cord-295807-68sukdb1	350	10	neuromuscular	neuromuscular	JJ
cord-295807-68sukdb1	350	11	drive	drive	NN
cord-295807-68sukdb1	350	12	[	[	-LRB-
cord-295807-68sukdb1	350	13	196	196	CD
cord-295807-68sukdb1	350	14	]	]	-RRB-
cord-295807-68sukdb1	350	15	and/or	and/or	CC
cord-295807-68sukdb1	350	16	a	a	DT
cord-295807-68sukdb1	350	17	decreased	decreased	JJ
cord-295807-68sukdb1	350	18	driving	drive	VBG
cord-295807-68sukdb1	350	19	force	force	NN
cord-295807-68sukdb1	350	20	for	for	IN
cord-295807-68sukdb1	350	21	lactate	lactate	NN
cord-295807-68sukdb1	350	22	efflux	efflux	NN
cord-295807-68sukdb1	350	23	[	[	-LRB-
cord-295807-68sukdb1	350	24	197	197	CD
cord-295807-68sukdb1	350	25	]	]	-RRB-
cord-295807-68sukdb1	350	26	.	.	.
cord-295807-68sukdb1	351	1	Regardless	regardless	RB
cord-295807-68sukdb1	351	2	,	,	,
cord-295807-68sukdb1	351	3	acidosis	acidosis	NN
cord-295807-68sukdb1	351	4	promotes	promote	VBZ
cord-295807-68sukdb1	351	5	degradation	degradation	NN
cord-295807-68sukdb1	351	6	of	of	IN
cord-295807-68sukdb1	351	7	muscle	muscle	NN
cord-295807-68sukdb1	351	8	protein	protein	NN
cord-295807-68sukdb1	351	9	[	[	-LRB-
cord-295807-68sukdb1	351	10	198	198	CD
cord-295807-68sukdb1	351	11	]	]	-RRB-
cord-295807-68sukdb1	351	12	.	.	.
cord-295807-68sukdb1	352	1	A	a	DT
cord-295807-68sukdb1	352	2	high	high	JJ
cord-295807-68sukdb1	352	3	estimated	estimate	VBN
cord-295807-68sukdb1	352	4	dietary	dietary	JJ
cord-295807-68sukdb1	352	5	acid	acid	NN
cord-295807-68sukdb1	352	6	load	load	NN
cord-295807-68sukdb1	352	7	has	have	VBZ
cord-295807-68sukdb1	352	8	been	be	VBN
cord-295807-68sukdb1	352	9	associated	associate	VBN
cord-295807-68sukdb1	352	10	with	with	IN
cord-295807-68sukdb1	352	11	frailty	frailty	NN
cord-295807-68sukdb1	352	12	in	in	IN
cord-295807-68sukdb1	352	13	elderly	elderly	JJ
cord-295807-68sukdb1	352	14	Japanese	japanese	JJ
cord-295807-68sukdb1	352	15	women	woman	NNS
cord-295807-68sukdb1	352	16	[	[	-LRB-
cord-295807-68sukdb1	352	17	199	199	CD
cord-295807-68sukdb1	352	18	]	]	-RRB-
cord-295807-68sukdb1	352	19	Recovery	Recovery	NNP
cord-295807-68sukdb1	352	20	from	from	IN
cord-295807-68sukdb1	352	21	lactic	lactic	JJ
cord-295807-68sukdb1	352	22	acidosis	acidosis	NN
cord-295807-68sukdb1	352	23	is	be	VBZ
cord-295807-68sukdb1	352	24	mediated	mediate	VBN
cord-295807-68sukdb1	352	25	by	by	IN
cord-295807-68sukdb1	352	26	MCTs	mct	NNS
cord-295807-68sukdb1	352	27	,	,	,
cord-295807-68sukdb1	352	28	NBCs	nbc	NNS
cord-295807-68sukdb1	352	29	,	,	,
cord-295807-68sukdb1	352	30	and	and	CC
cord-295807-68sukdb1	352	31	NHEs	nhe	NNS
cord-295807-68sukdb1	352	32	[	[	-LRB-
cord-295807-68sukdb1	352	33	200	200	CD
cord-295807-68sukdb1	352	34	]	]	-RRB-
cord-295807-68sukdb1	352	35	,	,	,
cord-295807-68sukdb1	352	36	while	while	IN
cord-295807-68sukdb1	352	37	CAIII	CAIII	NNP
cord-295807-68sukdb1	352	38	specifically	specifically	RB
cord-295807-68sukdb1	352	39	has	have	VBZ
cord-295807-68sukdb1	352	40	been	be	VBN
cord-295807-68sukdb1	352	41	shown	show	VBN
cord-295807-68sukdb1	352	42	to	to	IN
cord-295807-68sukdb1	352	43	plays	play	VBZ
cord-295807-68sukdb1	352	44	a	a	DT
cord-295807-68sukdb1	352	45	role	role	NN
cord-295807-68sukdb1	352	46	in	in	IN
cord-295807-68sukdb1	352	47	defense	defense	NN
cord-295807-68sukdb1	352	48	from	from	IN
cord-295807-68sukdb1	352	49	muscle	muscle	NN
cord-295807-68sukdb1	352	50	fatigue	fatigue	NN
cord-295807-68sukdb1	352	51	[	[	-LRB-
cord-295807-68sukdb1	352	52	201	201	CD
cord-295807-68sukdb1	352	53	]	]	-RRB-
cord-295807-68sukdb1	352	54	.	.	.
cord-295807-68sukdb1	353	1	Many	many	JJ
cord-295807-68sukdb1	353	2	studies	study	NNS
cord-295807-68sukdb1	353	3	suggest	suggest	VBP
cord-295807-68sukdb1	353	4	the	the	DT
cord-295807-68sukdb1	353	5	utility	utility	NN
cord-295807-68sukdb1	353	6	of	of	IN
cord-295807-68sukdb1	353	7	NaHCO3	nahco3	NN
cord-295807-68sukdb1	353	8	for	for	IN
cord-295807-68sukdb1	353	9	improving	improve	VBG
cord-295807-68sukdb1	353	10	exercise	exercise	NN
cord-295807-68sukdb1	353	11	performance	performance	NN
cord-295807-68sukdb1	353	12	.	.	.
cord-295807-68sukdb1	354	1	For	for	IN
cord-295807-68sukdb1	354	2	example	example	NN
cord-295807-68sukdb1	354	3	,	,	,
cord-295807-68sukdb1	354	4	induction	induction	NN
cord-295807-68sukdb1	354	5	of	of	IN
cord-295807-68sukdb1	354	6	MAlk	MAlk	NNP
cord-295807-68sukdb1	354	7	by	by	IN
cord-295807-68sukdb1	354	8	ingestion	ingestion	NN
cord-295807-68sukdb1	354	9	of	of	IN
cord-295807-68sukdb1	354	10	oral	oral	JJ
cord-295807-68sukdb1	354	11	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	354	12	solutions	solution	NNS
cord-295807-68sukdb1	354	13	has	have	VBZ
cord-295807-68sukdb1	354	14	been	be	VBN
cord-295807-68sukdb1	354	15	shown	show	VBN
cord-295807-68sukdb1	354	16	to	to	TO
cord-295807-68sukdb1	354	17	improve	improve	VB
cord-295807-68sukdb1	354	18	exercise	exercise	NN
cord-295807-68sukdb1	354	19	endurance	endurance	NN
cord-295807-68sukdb1	354	20	[	[	-LRB-
cord-295807-68sukdb1	354	21	202	202	CD
cord-295807-68sukdb1	354	22	]	]	-RRB-
cord-295807-68sukdb1	354	23	and	and	CC
cord-295807-68sukdb1	354	24	reduce	reduce	VB
cord-295807-68sukdb1	354	25	perception	perception	NN
cord-295807-68sukdb1	354	26	of	of	IN
cord-295807-68sukdb1	354	27	effort	effort	NN
cord-295807-68sukdb1	354	28	[	[	-LRB-
cord-295807-68sukdb1	354	29	203	203	CD
cord-295807-68sukdb1	354	30	]	]	-RRB-
cord-295807-68sukdb1	354	31	in	in	IN
cord-295807-68sukdb1	354	32	limited	limited	JJ
cord-295807-68sukdb1	354	33	trials	trial	NNS
cord-295807-68sukdb1	354	34	.	.	.
cord-295807-68sukdb1	355	1	However	however	RB
cord-295807-68sukdb1	355	2	,	,	,
cord-295807-68sukdb1	355	3	taking	take	VBG
cord-295807-68sukdb1	355	4	a	a	DT
cord-295807-68sukdb1	355	5	broader	broad	JJR
cord-295807-68sukdb1	355	6	view	view	NN
cord-295807-68sukdb1	355	7	of	of	IN
cord-295807-68sukdb1	355	8	the	the	DT
cord-295807-68sukdb1	355	9	field	field	NN
cord-295807-68sukdb1	355	10	,	,	,
cord-295807-68sukdb1	355	11	the	the	DT
cord-295807-68sukdb1	355	12	results	result	NNS
cord-295807-68sukdb1	355	13	of	of	IN
cord-295807-68sukdb1	355	14	trials	trial	NNS
cord-295807-68sukdb1	355	15	that	that	WDT
cord-295807-68sukdb1	355	16	link	link	VBP
cord-295807-68sukdb1	355	17	pH	ph	NN
cord-295807-68sukdb1	355	18	and	and	CC
cord-295807-68sukdb1	355	19	exercise	exercise	NN
cord-295807-68sukdb1	355	20	performance	performance	NN
cord-295807-68sukdb1	355	21	are	be	VBP
cord-295807-68sukdb1	355	22	deemed	deem	VBN
cord-295807-68sukdb1	355	23	inconclusive	inconclusive	JJ
cord-295807-68sukdb1	355	24	due	due	IN
cord-295807-68sukdb1	355	25	to	to	IN
cord-295807-68sukdb1	355	26	inconsistent	inconsistent	JJ
cord-295807-68sukdb1	355	27	methodology	methodology	NN
cord-295807-68sukdb1	355	28	and	and	CC
cord-295807-68sukdb1	355	29	subgroup	subgroup	NN
cord-295807-68sukdb1	355	30	effects	effect	NNS
cord-295807-68sukdb1	355	31	[	[	-LRB-
cord-295807-68sukdb1	355	32	204	204	CD
cord-295807-68sukdb1	355	33	,	,	,
cord-295807-68sukdb1	355	34	205	205	CD
cord-295807-68sukdb1	355	35	]	]	-RRB-
cord-295807-68sukdb1	355	36	.	.	.
cord-295807-68sukdb1	356	1	It	-PRON-	PRP
cord-295807-68sukdb1	356	2	has	have	VBZ
cord-295807-68sukdb1	356	3	also	also	RB
cord-295807-68sukdb1	356	4	been	be	VBN
cord-295807-68sukdb1	356	5	suggested	suggest	VBN
cord-295807-68sukdb1	356	6	that	that	IN
cord-295807-68sukdb1	356	7	any	any	DT
cord-295807-68sukdb1	356	8	competitive	competitive	JJ
cord-295807-68sukdb1	356	9	benefits	benefit	NNS
cord-295807-68sukdb1	356	10	that	that	WDT
cord-295807-68sukdb1	356	11	could	could	MD
cord-295807-68sukdb1	356	12	be	be	VB
cord-295807-68sukdb1	356	13	gained	gain	VBN
cord-295807-68sukdb1	356	14	from	from	IN
cord-295807-68sukdb1	356	15	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	356	16	administration	administration	NNP
cord-295807-68sukdb1	356	17	,	,	,
cord-295807-68sukdb1	356	18	from	from	IN
cord-295807-68sukdb1	356	19	an	an	DT
cord-295807-68sukdb1	356	20	athletic	athletic	JJ
cord-295807-68sukdb1	356	21	viewpoint	viewpoint	NN
cord-295807-68sukdb1	356	22	,	,	,
cord-295807-68sukdb1	356	23	may	may	MD
cord-295807-68sukdb1	356	24	be	be	VB
cord-295807-68sukdb1	356	25	outweighed	outweigh	VBN
cord-295807-68sukdb1	356	26	by	by	IN
cord-295807-68sukdb1	356	27	gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	356	28	side	side	NN
cord-295807-68sukdb1	356	29	effects	effect	NNS
cord-295807-68sukdb1	356	30	such	such	JJ
cord-295807-68sukdb1	356	31	as	as	IN
cord-295807-68sukdb1	356	32	bloating	bloat	VBG
cord-295807-68sukdb1	356	33	[	[	-LRB-
cord-295807-68sukdb1	356	34	206	206	CD
cord-295807-68sukdb1	356	35	]	]	-RRB-
cord-295807-68sukdb1	356	36	.	.	.
cord-295807-68sukdb1	357	1	Away	away	RB
cord-295807-68sukdb1	357	2	from	from	IN
cord-295807-68sukdb1	357	3	the	the	DT
cord-295807-68sukdb1	357	4	arena	arena	NN
cord-295807-68sukdb1	357	5	,	,	,
cord-295807-68sukdb1	357	6	HCO3administration	hco3administration	NN
cord-295807-68sukdb1	357	7	or	or	CC
cord-295807-68sukdb1	357	8	a	a	DT
cord-295807-68sukdb1	357	9	reduced	reduce	VBN
cord-295807-68sukdb1	357	10	dietary	dietary	JJ
cord-295807-68sukdb1	357	11	acid	acid	NN
cord-295807-68sukdb1	357	12	load	load	NN
cord-295807-68sukdb1	357	13	could	could	MD
cord-295807-68sukdb1	357	14	have	have	VB
cord-295807-68sukdb1	357	15	value	value	NN
cord-295807-68sukdb1	357	16	in	in	IN
cord-295807-68sukdb1	357	17	maintaining	maintain	VBG
cord-295807-68sukdb1	357	18	muscle	muscle	NN
cord-295807-68sukdb1	357	19	mass	mass	NN
cord-295807-68sukdb1	357	20	in	in	IN
cord-295807-68sukdb1	357	21	older	old	JJR
cord-295807-68sukdb1	357	22	adults	adult	NNS
cord-295807-68sukdb1	357	23	[	[	-LRB-
cord-295807-68sukdb1	357	24	207	207	CD
cord-295807-68sukdb1	357	25	,	,	,
cord-295807-68sukdb1	357	26	208	208	CD
cord-295807-68sukdb1	357	27	]	]	-RRB-
cord-295807-68sukdb1	357	28	.	.	.
cord-295807-68sukdb1	358	1	Mineralized	mineralized	JJ
cord-295807-68sukdb1	358	2	material	material	NN
cord-295807-68sukdb1	358	3	is	be	VBZ
cord-295807-68sukdb1	358	4	eroded	erode	VBN
cord-295807-68sukdb1	358	5	by	by	IN
cord-295807-68sukdb1	358	6	acids	acid	NNS
cord-295807-68sukdb1	358	7	as	as	IN
cord-295807-68sukdb1	358	8	is	be	VBZ
cord-295807-68sukdb1	358	9	evident	evident	JJ
cord-295807-68sukdb1	358	10	in	in	IN
cord-295807-68sukdb1	358	11	the	the	DT
cord-295807-68sukdb1	358	12	case	case	NN
cord-295807-68sukdb1	358	13	of	of	IN
cord-295807-68sukdb1	358	14	tooth	tooth	NN
cord-295807-68sukdb1	358	15	enamel	enamel	NN
cord-295807-68sukdb1	358	16	,	,	,
cord-295807-68sukdb1	358	17	which	which	WDT
cord-295807-68sukdb1	358	18	is	be	VBZ
cord-295807-68sukdb1	358	19	subject	subject	JJ
cord-295807-68sukdb1	358	20	to	to	IN
cord-295807-68sukdb1	358	21	demineralization	demineralization	NN
cord-295807-68sukdb1	358	22	by	by	IN
cord-295807-68sukdb1	358	23	dietary	dietary	JJ
cord-295807-68sukdb1	358	24	acids	acid	NNS
cord-295807-68sukdb1	358	25	(	(	-LRB-
cord-295807-68sukdb1	358	26	see	see	VB
cord-295807-68sukdb1	358	27	Oral	Oral	NNP
cord-295807-68sukdb1	358	28	Health	Health	NNP
cord-295807-68sukdb1	358	29	)	)	-RRB-
cord-295807-68sukdb1	358	30	.	.	.
cord-295807-68sukdb1	359	1	However	however	RB
cord-295807-68sukdb1	359	2	acidosis	acidosis	NN
cord-295807-68sukdb1	359	3	also	also	RB
cord-295807-68sukdb1	359	4	inhibits	inhibit	VBZ
cord-295807-68sukdb1	359	5	bone	bone	NN
cord-295807-68sukdb1	359	6	growth	growth	NN
cord-295807-68sukdb1	359	7	by	by	IN
cord-295807-68sukdb1	359	8	inhibiting	inhibit	VBG
cord-295807-68sukdb1	359	9	osteoblasts	osteoblast	NNS
cord-295807-68sukdb1	359	10	,	,	,
cord-295807-68sukdb1	359	11	stimulating	stimulate	VBG
cord-295807-68sukdb1	359	12	the	the	DT
cord-295807-68sukdb1	359	13	activity	activity	NN
cord-295807-68sukdb1	359	14	of	of	IN
cord-295807-68sukdb1	359	15	bone	bone	NN
cord-295807-68sukdb1	359	16	-	-	HYPH
cord-295807-68sukdb1	359	17	resorbing	resorb	VBG
cord-295807-68sukdb1	359	18	osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	359	19	[	[	-LRB-
cord-295807-68sukdb1	359	20	209	209	CD
cord-295807-68sukdb1	359	21	]	]	-RRB-
cord-295807-68sukdb1	359	22	,	,	,
cord-295807-68sukdb1	359	23	and	and	CC
cord-295807-68sukdb1	359	24	influencing	influence	VBG
cord-295807-68sukdb1	359	25	hormonal	hormonal	JJ
cord-295807-68sukdb1	359	26	axes	axis	NNS
cord-295807-68sukdb1	359	27	[	[	-LRB-
cord-295807-68sukdb1	359	28	198	198	CD
cord-295807-68sukdb1	359	29	,	,	,
cord-295807-68sukdb1	359	30	210	210	CD
cord-295807-68sukdb1	359	31	]	]	-RRB-
cord-295807-68sukdb1	359	32	(	(	-LRB-
cord-295807-68sukdb1	359	33	see	see	VB
cord-295807-68sukdb1	359	34	also	also	RB
cord-295807-68sukdb1	359	35	section	section	NN
cord-295807-68sukdb1	359	36	4.11	4.11	CD
cord-295807-68sukdb1	359	37	about	about	IN
cord-295807-68sukdb1	359	38	the	the	DT
cord-295807-68sukdb1	359	39	effects	effect	NNS
cord-295807-68sukdb1	359	40	of	of	IN
cord-295807-68sukdb1	359	41	pH	ph	NN
cord-295807-68sukdb1	359	42	on	on	IN
cord-295807-68sukdb1	359	43	the	the	DT
cord-295807-68sukdb1	359	44	endocrine	endocrine	NN
cord-295807-68sukdb1	359	45	system	system	NN
cord-295807-68sukdb1	359	46	)	)	-RRB-
cord-295807-68sukdb1	359	47	.	.	.
cord-295807-68sukdb1	360	1	Accordingly	accordingly	RB
cord-295807-68sukdb1	360	2	,	,	,
cord-295807-68sukdb1	360	3	serum	serum	NN
cord-295807-68sukdb1	360	4	[	[	-LRB-
cord-295807-68sukdb1	360	5	HCO3	HCO3	NNP
cord-295807-68sukdb1	360	6	-	-	,
cord-295807-68sukdb1	360	7	]	]	-RRB-
cord-295807-68sukdb1	360	8	positively	positively	RB
cord-295807-68sukdb1	360	9	correlates	correlate	VBZ
cord-295807-68sukdb1	360	10	with	with	IN
cord-295807-68sukdb1	360	11	bone	bone	NN
cord-295807-68sukdb1	360	12	mineral	mineral	NN
cord-295807-68sukdb1	360	13	density	density	NN
cord-295807-68sukdb1	360	14	(	(	-LRB-
cord-295807-68sukdb1	360	15	BMD	BMD	NNP
cord-295807-68sukdb1	360	16	)	)	-RRB-
cord-295807-68sukdb1	360	17	[	[	-LRB-
cord-295807-68sukdb1	360	18	211	211	CD
cord-295807-68sukdb1	360	19	]	]	-RRB-
cord-295807-68sukdb1	360	20	and	and	CC
cord-295807-68sukdb1	360	21	negatively	negatively	RB
cord-295807-68sukdb1	360	22	correlates	correlate	VBZ
cord-295807-68sukdb1	360	23	with	with	IN
cord-295807-68sukdb1	360	24	levels	level	NNS
cord-295807-68sukdb1	360	25	of	of	IN
cord-295807-68sukdb1	360	26	serum	serum	NN
cord-295807-68sukdb1	360	27	parathyroid	parathyroid	NN
cord-295807-68sukdb1	360	28	hormone	hormone	NN
cord-295807-68sukdb1	360	29	(	(	-LRB-
cord-295807-68sukdb1	360	30	which	which	WDT
cord-295807-68sukdb1	360	31	promotes	promote	VBZ
cord-295807-68sukdb1	360	32	bone	bone	NN
cord-295807-68sukdb1	360	33	resorption	resorption	NN
cord-295807-68sukdb1	360	34	)	)	-RRB-
cord-295807-68sukdb1	360	35	[	[	-LRB-
cord-295807-68sukdb1	360	36	212	212	CD
cord-295807-68sukdb1	360	37	]	]	-RRB-
cord-295807-68sukdb1	360	38	.	.	.
cord-295807-68sukdb1	361	1	At	at	IN
cord-295807-68sukdb1	361	2	a	a	DT
cord-295807-68sukdb1	361	3	local	local	JJ
cord-295807-68sukdb1	361	4	level	level	NN
cord-295807-68sukdb1	361	5	,	,	,
cord-295807-68sukdb1	361	6	the	the	DT
cord-295807-68sukdb1	361	7	process	process	NN
cord-295807-68sukdb1	361	8	of	of	IN
cord-295807-68sukdb1	361	9	bone	bone	NN
cord-295807-68sukdb1	361	10	remodeling	remodeling	NN
cord-295807-68sukdb1	361	11	,	,	,
cord-295807-68sukdb1	361	12	as	as	RB
cord-295807-68sukdb1	361	13	well	well	RB
cord-295807-68sukdb1	361	14	as	as	IN
cord-295807-68sukdb1	361	15	the	the	DT
cord-295807-68sukdb1	361	16	hormonal	hormonal	JJ
cord-295807-68sukdb1	361	17	mobilization	mobilization	NN
cord-295807-68sukdb1	361	18	of	of	IN
cord-295807-68sukdb1	361	19	Ca	Ca	NNP
cord-295807-68sukdb1	361	20	2	2	CD
cord-295807-68sukdb1	361	21	+	+	SYM
cord-295807-68sukdb1	361	22	and	and	CC
cord-295807-68sukdb1	361	23	Pi	pi	NN
cord-295807-68sukdb1	361	24	from	from	IN
cord-295807-68sukdb1	361	25	bone	bone	NN
cord-295807-68sukdb1	361	26	,	,	,
cord-295807-68sukdb1	361	27	requires	require	VBZ
cord-295807-68sukdb1	361	28	that	that	IN
cord-295807-68sukdb1	361	29	osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	361	30	secrete	secrete	VBP
cord-295807-68sukdb1	361	31	H	h	NN
cord-295807-68sukdb1	361	32	+	+	CC
cord-295807-68sukdb1	361	33	onto	onto	IN
cord-295807-68sukdb1	361	34	the	the	DT
cord-295807-68sukdb1	361	35	bone	bone	NN
cord-295807-68sukdb1	361	36	surface	surface	NN
cord-295807-68sukdb1	361	37	.	.	.
cord-295807-68sukdb1	362	1	These	these	DT
cord-295807-68sukdb1	362	2	cells	cell	NNS
cord-295807-68sukdb1	362	3	express	express	VBP
cord-295807-68sukdb1	362	4	intracellular	intracellular	JJ
cord-295807-68sukdb1	362	5	CAII	CAII	NNS
cord-295807-68sukdb1	362	6	to	to	TO
cord-295807-68sukdb1	362	7	generate	generate	VB
cord-295807-68sukdb1	362	8	H	h	NN
cord-295807-68sukdb1	362	9	+	+	CC
cord-295807-68sukdb1	362	10	and	and	CC
cord-295807-68sukdb1	362	11	HCO3	HCO3	NNP
cord-295807-68sukdb1	362	12	-	-	HYPH
cord-295807-68sukdb1	362	13	,	,	,
cord-295807-68sukdb1	362	14	an	an	DT
cord-295807-68sukdb1	362	15	apical	apical	JJ
cord-295807-68sukdb1	362	16	v	v	NN
cord-295807-68sukdb1	362	17	-	-	HYPH
cord-295807-68sukdb1	362	18	type	type	NN
cord-295807-68sukdb1	362	19	H	h	NN
cord-295807-68sukdb1	362	20	+	+	CC
cord-295807-68sukdb1	362	21	-ATPase	-atpase	NN
cord-295807-68sukdb1	362	22	to	to	TO
cord-295807-68sukdb1	362	23	secrete	secrete	VB
cord-295807-68sukdb1	362	24	H	h	NN
cord-295807-68sukdb1	363	1	+	+	CC
cord-295807-68sukdb1	363	2	onto	onto	IN
cord-295807-68sukdb1	363	3	the	the	DT
cord-295807-68sukdb1	363	4	bone	bone	NN
cord-295807-68sukdb1	363	5	surface	surface	NN
cord-295807-68sukdb1	363	6	,	,	,
cord-295807-68sukdb1	363	7	and	and	CC
cord-295807-68sukdb1	363	8	basolateral	basolateral	JJ
cord-295807-68sukdb1	363	9	AE2	AE2	NNS
cord-295807-68sukdb1	363	10	to	to	TO
cord-295807-68sukdb1	363	11	export	export	NN
cord-295807-68sukdb1	364	1	HCO3and	hco3and	CC
cord-295807-68sukdb1	364	2	defend	defend	VB
cord-295807-68sukdb1	364	3	osteoclast	osteoclast	NN
cord-295807-68sukdb1	364	4	pHi	phi	JJ
cord-295807-68sukdb1	364	5	from	from	IN
cord-295807-68sukdb1	364	6	alkalosis	alkalosis	NN
cord-295807-68sukdb1	364	7	during	during	IN
cord-295807-68sukdb1	364	8	H	h	NN
cord-295807-68sukdb1	364	9	+	+	CC
cord-295807-68sukdb1	364	10	secretion	secretion	NN
cord-295807-68sukdb1	364	11	(	(	-LRB-
cord-295807-68sukdb1	364	12	Figure	Figure	NNP
cord-295807-68sukdb1	364	13	8	8	CD
cord-295807-68sukdb1	364	14	)	)	-RRB-
cord-295807-68sukdb1	364	15	.	.	.
cord-295807-68sukdb1	365	1	Mutations	mutation	NNS
cord-295807-68sukdb1	365	2	in	in	IN
cord-295807-68sukdb1	365	3	the	the	DT
cord-295807-68sukdb1	365	4	v	v	NN
cord-295807-68sukdb1	365	5	-	-	HYPH
cord-295807-68sukdb1	365	6	type	type	NN
cord-295807-68sukdb1	365	7	ATPase	ATPase	NNP
cord-295807-68sukdb1	365	8	and	and	CC
cord-295807-68sukdb1	365	9	CAII	CAII	NNP
cord-295807-68sukdb1	365	10	disable	disable	VB
cord-295807-68sukdb1	365	11	bone	bone	NN
cord-295807-68sukdb1	365	12	resorption	resorption	NN
cord-295807-68sukdb1	365	13	by	by	IN
cord-295807-68sukdb1	365	14	osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	365	15	and	and	CC
cord-295807-68sukdb1	365	16	are	be	VBP
cord-295807-68sukdb1	365	17	associated	associate	VBN
cord-295807-68sukdb1	365	18	with	with	IN
cord-295807-68sukdb1	365	19	increased	increase	VBN
cord-295807-68sukdb1	365	20	bone	bone	NN
cord-295807-68sukdb1	365	21	density	density	NN
cord-295807-68sukdb1	365	22	and	and	CC
cord-295807-68sukdb1	365	23	osteopetrosis	osteopetrosis	NN
cord-295807-68sukdb1	365	24	in	in	IN
cord-295807-68sukdb1	365	25	humans	human	NNS
cord-295807-68sukdb1	365	26	[	[	-LRB-
cord-295807-68sukdb1	365	27	213	213	CD
cord-295807-68sukdb1	365	28	,	,	,
cord-295807-68sukdb1	365	29	214	214	CD
cord-295807-68sukdb1	365	30	]	]	-RRB-
cord-295807-68sukdb1	365	31	.	.	.
cord-295807-68sukdb1	366	1	The	the	DT
cord-295807-68sukdb1	366	2	acid	acid	NN
cord-295807-68sukdb1	366	3	-	-	HYPH
cord-295807-68sukdb1	366	4	base	base	NN
cord-295807-68sukdb1	366	5	regulating	regulating	NN
cord-295807-68sukdb1	366	6	proteins	protein	NNS
cord-295807-68sukdb1	366	7	of	of	IN
cord-295807-68sukdb1	366	8	osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	366	9	are	be	VBP
cord-295807-68sukdb1	366	10	amenable	amenable	JJ
cord-295807-68sukdb1	366	11	to	to	IN
cord-295807-68sukdb1	366	12	pharmaceutical	pharmaceutical	JJ
cord-295807-68sukdb1	366	13	modulation	modulation	NN
cord-295807-68sukdb1	366	14	and	and	CC
cord-295807-68sukdb1	366	15	their	-PRON-	PRP$
cord-295807-68sukdb1	366	16	blockade	blockade	NN
cord-295807-68sukdb1	366	17	ought	ought	MD
cord-295807-68sukdb1	366	18	to	to	TO
cord-295807-68sukdb1	366	19	be	be	VB
cord-295807-68sukdb1	366	20	protective	protective	JJ
cord-295807-68sukdb1	366	21	of	of	IN
cord-295807-68sukdb1	366	22	osteoporosis	osteoporosis	NN
cord-295807-68sukdb1	366	23	.	.	.
cord-295807-68sukdb1	367	1	For	for	IN
cord-295807-68sukdb1	367	2	example	example	NN
cord-295807-68sukdb1	367	3	,	,	,
cord-295807-68sukdb1	367	4	AE2	AE2	NNP
cord-295807-68sukdb1	367	5	may	may	MD
cord-295807-68sukdb1	367	6	be	be	VB
cord-295807-68sukdb1	367	7	a	a	DT
cord-295807-68sukdb1	367	8	useful	useful	JJ
cord-295807-68sukdb1	367	9	target	target	NN
cord-295807-68sukdb1	367	10	for	for	IN
cord-295807-68sukdb1	367	11	increasing	increase	VBG
cord-295807-68sukdb1	367	12	BMD	BMD	NNP
cord-295807-68sukdb1	367	13	because	because	IN
cord-295807-68sukdb1	367	14	BMD	BMD	NNP
cord-295807-68sukdb1	367	15	is	be	VBZ
cord-295807-68sukdb1	367	16	elevated	elevate	VBN
cord-295807-68sukdb1	367	17	in	in	IN
cord-295807-68sukdb1	367	18	AE2-null	AE2-null	NNP
cord-295807-68sukdb1	367	19	mice	mouse	NNS
cord-295807-68sukdb1	367	20	and	and	CC
cord-295807-68sukdb1	367	21	cattle	cattle	NNS
cord-295807-68sukdb1	367	22	(	(	-LRB-
cord-295807-68sukdb1	367	23	reviewed	review	VBN
cord-295807-68sukdb1	367	24	in	in	IN
cord-295807-68sukdb1	367	25	ref	ref	NN
cord-295807-68sukdb1	367	26	.	.	.
cord-295807-68sukdb1	368	1	[	[	-LRB-
cord-295807-68sukdb1	368	2	215	215	CD
cord-295807-68sukdb1	368	3	]	]	-RRB-
cord-295807-68sukdb1	368	4	)	)	-RRB-
cord-295807-68sukdb1	368	5	.	.	.
cord-295807-68sukdb1	369	1	Regarding	regard	VBG
cord-295807-68sukdb1	369	2	CAII	CAII	NNP
cord-295807-68sukdb1	369	3	,	,	,
cord-295807-68sukdb1	369	4	one	one	CD
cord-295807-68sukdb1	369	5	study	study	NN
cord-295807-68sukdb1	369	6	showed	show	VBD
cord-295807-68sukdb1	369	7	a	a	DT
cord-295807-68sukdb1	369	8	fortuitous	fortuitous	JJ
cord-295807-68sukdb1	369	9	bone	bone	NN
cord-295807-68sukdb1	369	10	-	-	HYPH
cord-295807-68sukdb1	369	11	sparing	spare	VBG
cord-295807-68sukdb1	369	12	effect	effect	NN
cord-295807-68sukdb1	369	13	in	in	IN
cord-295807-68sukdb1	369	14	post	post	JJ
cord-295807-68sukdb1	369	15	-	-	JJ
cord-295807-68sukdb1	369	16	menopausal	menopausal	JJ
cord-295807-68sukdb1	369	17	women	woman	NNS
cord-295807-68sukdb1	369	18	were	be	VBD
cord-295807-68sukdb1	369	19	chronic	chronic	JJ
cord-295807-68sukdb1	369	20	users	user	NNS
cord-295807-68sukdb1	369	21	of	of	IN
cord-295807-68sukdb1	369	22	CA	CA	NNP
cord-295807-68sukdb1	369	23	-	-	HYPH
cord-295807-68sukdb1	369	24	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	369	25	for	for	IN
cord-295807-68sukdb1	369	26	glaucoma	glaucoma	NN
cord-295807-68sukdb1	369	27	treatment	treatment	NN
cord-295807-68sukdb1	369	28	,	,	,
cord-295807-68sukdb1	369	29	[	[	-LRB-
cord-295807-68sukdb1	369	30	216	216	CD
cord-295807-68sukdb1	369	31	]	]	-RRB-
cord-295807-68sukdb1	369	32	.	.	.
cord-295807-68sukdb1	370	1	Another	another	DT
cord-295807-68sukdb1	370	2	study	study	NN
cord-295807-68sukdb1	370	3	showed	show	VBD
cord-295807-68sukdb1	370	4	a	a	DT
cord-295807-68sukdb1	370	5	paradoxical	paradoxical	JJ
cord-295807-68sukdb1	370	6	,	,	,
cord-295807-68sukdb1	370	7	but	but	CC
cord-295807-68sukdb1	370	8	therapeutically	therapeutically	RB
cord-295807-68sukdb1	370	9	valuable	valuable	JJ
cord-295807-68sukdb1	370	10	,	,	,
cord-295807-68sukdb1	370	11	BMD	bmd	NN
cord-295807-68sukdb1	370	12	-	-	HYPH
cord-295807-68sukdb1	370	13	lowering	lower	VBG
cord-295807-68sukdb1	370	14	effect	effect	NN
cord-295807-68sukdb1	370	15	of	of	IN
cord-295807-68sukdb1	370	16	CA	CA	NNP
cord-295807-68sukdb1	370	17	inhibition	inhibition	NN
cord-295807-68sukdb1	370	18	in	in	IN
cord-295807-68sukdb1	370	19	three	three	CD
cord-295807-68sukdb1	370	20	children	child	NNS
cord-295807-68sukdb1	370	21	with	with	IN
cord-295807-68sukdb1	370	22	sclerosing	sclerose	VBG
cord-295807-68sukdb1	370	23	bone	bone	NN
cord-295807-68sukdb1	370	24	dysplasias	dysplasias	NNP
cord-295807-68sukdb1	370	25	.	.	.
cord-295807-68sukdb1	371	1	In	in	IN
cord-295807-68sukdb1	371	2	these	these	DT
cord-295807-68sukdb1	371	3	children	child	NNS
cord-295807-68sukdb1	371	4	,	,	,
cord-295807-68sukdb1	371	5	osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	371	6	are	be	VBP
cord-295807-68sukdb1	371	7	already	already	RB
cord-295807-68sukdb1	371	8	defective	defective	JJ
cord-295807-68sukdb1	371	9	so	so	RB
cord-295807-68sukdb1	372	1	the	the	DT
cord-295807-68sukdb1	372	2	predominant	predominant	JJ
cord-295807-68sukdb1	372	3	effect	effect	NN
cord-295807-68sukdb1	372	4	of	of	IN
cord-295807-68sukdb1	372	5	CA	ca	NN
cord-295807-68sukdb1	372	6	-	-	HYPH
cord-295807-68sukdb1	372	7	inhibition	inhibition	NN
cord-295807-68sukdb1	372	8	is	be	VBZ
cord-295807-68sukdb1	372	9	induction	induction	NN
cord-295807-68sukdb1	372	10	of	of	IN
cord-295807-68sukdb1	372	11	chronic	chronic	JJ
cord-295807-68sukdb1	372	12	MAc	MAc	NNP
cord-295807-68sukdb1	372	13	which	which	WDT
cord-295807-68sukdb1	372	14	promotes	promote	VBZ
cord-295807-68sukdb1	372	15	bone	bone	NN
cord-295807-68sukdb1	372	16	resorption	resorption	NN
cord-295807-68sukdb1	372	17	[	[	-LRB-
cord-295807-68sukdb1	372	18	217	217	CD
cord-295807-68sukdb1	372	19	]	]	-RRB-
cord-295807-68sukdb1	372	20	.	.	.
cord-295807-68sukdb1	373	1	The	the	DT
cord-295807-68sukdb1	373	2	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	373	3	utility	utility	NN
cord-295807-68sukdb1	373	4	of	of	IN
cord-295807-68sukdb1	373	5	proton	proton	NN
cord-295807-68sukdb1	373	6	pump	pump	NN
cord-295807-68sukdb1	373	7	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	373	8	(	(	-LRB-
cord-295807-68sukdb1	373	9	PPIs	ppi	NNS
cord-295807-68sukdb1	373	10	)	)	-RRB-
cord-295807-68sukdb1	373	11	to	to	TO
cord-295807-68sukdb1	373	12	treat	treat	VB
cord-295807-68sukdb1	373	13	osteoporosis	osteoporosis	NN
cord-295807-68sukdb1	373	14	is	be	VBZ
cord-295807-68sukdb1	373	15	negated	negate	VBN
cord-295807-68sukdb1	373	16	by	by	IN
cord-295807-68sukdb1	373	17	their	-PRON-	PRP$
cord-295807-68sukdb1	373	18	negative	negative	JJ
cord-295807-68sukdb1	373	19	influence	influence	NN
cord-295807-68sukdb1	373	20	on	on	IN
cord-295807-68sukdb1	373	21	intestinal	intestinal	JJ
cord-295807-68sukdb1	373	22	Ca	Ca	NNP
cord-295807-68sukdb1	373	23	2	2	CD
cord-295807-68sukdb1	373	24	+	+	CC
cord-295807-68sukdb1	373	25	absorption	absorption	NN
cord-295807-68sukdb1	373	26	[	[	-LRB-
cord-295807-68sukdb1	373	27	218	218	CD
cord-295807-68sukdb1	373	28	]	]	-RRB-
cord-295807-68sukdb1	373	29	.	.	.
cord-295807-68sukdb1	374	1	In	in	IN
cord-295807-68sukdb1	374	2	fact	fact	NN
cord-295807-68sukdb1	374	3	,	,	,
cord-295807-68sukdb1	374	4	several	several	JJ
cord-295807-68sukdb1	374	5	studies	study	NNS
cord-295807-68sukdb1	374	6	link	link	VBP
cord-295807-68sukdb1	374	7	PPI	PPI	NNP
cord-295807-68sukdb1	374	8	use	use	NN
cord-295807-68sukdb1	374	9	with	with	IN
cord-295807-68sukdb1	374	10	fracture	fracture	NN
cord-295807-68sukdb1	374	11	susceptibility	susceptibility	NN
cord-295807-68sukdb1	374	12	and	and	CC
cord-295807-68sukdb1	374	13	low	low	JJ
cord-295807-68sukdb1	374	14	BMD	bmd	NN
cord-295807-68sukdb1	374	15	(	(	-LRB-
cord-295807-68sukdb1	374	16	reviewed	review	VBN
cord-295807-68sukdb1	374	17	in	in	IN
cord-295807-68sukdb1	374	18	refs	ref	NNS
cord-295807-68sukdb1	374	19	.	.	.
cord-295807-68sukdb1	375	1	[	[	-LRB-
cord-295807-68sukdb1	375	2	219	219	CD
cord-295807-68sukdb1	375	3	,	,	,
cord-295807-68sukdb1	375	4	220	220	CD
cord-295807-68sukdb1	375	5	]	]	-RRB-
cord-295807-68sukdb1	375	6	)	)	-RRB-
cord-295807-68sukdb1	375	7	.	.	.
cord-295807-68sukdb1	376	1	Because	because	IN
cord-295807-68sukdb1	376	2	of	of	IN
cord-295807-68sukdb1	376	3	these	these	DT
cord-295807-68sukdb1	376	4	side	side	NN
cord-295807-68sukdb1	376	5	effects	effect	NNS
cord-295807-68sukdb1	376	6	,	,	,
cord-295807-68sukdb1	376	7	PPIs	ppi	NNS
cord-295807-68sukdb1	376	8	are	be	VBP
cord-295807-68sukdb1	376	9	used	use	VBN
cord-295807-68sukdb1	376	10	with	with	IN
cord-295807-68sukdb1	376	11	caution	caution	NN
cord-295807-68sukdb1	376	12	in	in	IN
cord-295807-68sukdb1	376	13	some	some	DT
cord-295807-68sukdb1	376	14	groups	group	NNS
cord-295807-68sukdb1	376	15	who	who	WP
cord-295807-68sukdb1	376	16	may	may	MD
cord-295807-68sukdb1	376	17	take	take	VB
cord-295807-68sukdb1	376	18	them	-PRON-	PRP
cord-295807-68sukdb1	376	19	as	as	IN
cord-295807-68sukdb1	376	20	antacid	antacid	JJ
cord-295807-68sukdb1	376	21	therapy	therapy	NN
cord-295807-68sukdb1	376	22	[	[	-LRB-
cord-295807-68sukdb1	376	23	219	219	CD
cord-295807-68sukdb1	376	24	,	,	,
cord-295807-68sukdb1	376	25	220	220	CD
cord-295807-68sukdb1	376	26	]	]	-RRB-
cord-295807-68sukdb1	376	27	(	(	-LRB-
cord-295807-68sukdb1	376	28	and	and	CC
cord-295807-68sukdb1	376	29	see	see	VB
cord-295807-68sukdb1	376	30	next	next	JJ
cord-295807-68sukdb1	376	31	section	section	NN
cord-295807-68sukdb1	376	32	)	)	-RRB-
cord-295807-68sukdb1	376	33	.	.	.
cord-295807-68sukdb1	377	1	The	the	DT
cord-295807-68sukdb1	377	2	three	three	CD
cord-295807-68sukdb1	377	3	major	major	JJ
cord-295807-68sukdb1	377	4	health	health	NN
cord-295807-68sukdb1	377	5	-	-	HYPH
cord-295807-68sukdb1	377	6	related	relate	VBN
cord-295807-68sukdb1	377	7	aspects	aspect	NNS
cord-295807-68sukdb1	377	8	of	of	IN
cord-295807-68sukdb1	377	9	acid	acid	NN
cord-295807-68sukdb1	377	10	-	-	HYPH
cord-295807-68sukdb1	377	11	base	base	NN
cord-295807-68sukdb1	377	12	in	in	IN
cord-295807-68sukdb1	377	13	this	this	DT
cord-295807-68sukdb1	377	14	system	system	NN
cord-295807-68sukdb1	377	15	are	be	VBP
cord-295807-68sukdb1	377	16	the	the	DT
cord-295807-68sukdb1	377	17	roles	role	NNS
cord-295807-68sukdb1	377	18	of	of	IN
cord-295807-68sukdb1	377	19	salivary	salivary	NN
cord-295807-68sukdb1	377	20	HCO3	HCO3	NNP
cord-295807-68sukdb1	377	21	in	in	IN
cord-295807-68sukdb1	377	22	defense	defense	NN
cord-295807-68sukdb1	377	23	of	of	IN
cord-295807-68sukdb1	377	24	enamel	enamel	NN
cord-295807-68sukdb1	377	25	(	(	-LRB-
cord-295807-68sukdb1	377	26	which	which	WDT
cord-295807-68sukdb1	377	27	are	be	VBP
cord-295807-68sukdb1	377	28	discussed	discuss	VBN
cord-295807-68sukdb1	377	29	in	in	IN
cord-295807-68sukdb1	377	30	section	section	NN
cord-295807-68sukdb1	377	31	5.4	5.4	CD
cord-295807-68sukdb1	377	32	Oral	Oral	NNP
cord-295807-68sukdb1	377	33	Health	Health	NNP
cord-295807-68sukdb1	377	34	)	)	-RRB-
cord-295807-68sukdb1	377	35	,	,	,
cord-295807-68sukdb1	377	36	gastric	gastric	JJ
cord-295807-68sukdb1	377	37	acid	acid	NN
cord-295807-68sukdb1	377	38	secretion	secretion	NN
cord-295807-68sukdb1	377	39	,	,	,
cord-295807-68sukdb1	377	40	and	and	CC
cord-295807-68sukdb1	377	41	peptic	peptic	JJ
cord-295807-68sukdb1	377	42	ulceration	ulceration	NN
cord-295807-68sukdb1	377	43	with	with	IN
cord-295807-68sukdb1	377	44	Helicobacter	Helicobacter	NNP
cord-295807-68sukdb1	377	45	pylori	pylori	NN
cord-295807-68sukdb1	377	46	.	.	.
cord-295807-68sukdb1	378	1	Gastric	gastric	JJ
cord-295807-68sukdb1	378	2	acid	acid	NN
cord-295807-68sukdb1	378	3	is	be	VBZ
cord-295807-68sukdb1	378	4	required	require	VBN
cord-295807-68sukdb1	378	5	to	to	TO
cord-295807-68sukdb1	378	6	activate	activate	VB
cord-295807-68sukdb1	378	7	digestive	digestive	JJ
cord-295807-68sukdb1	378	8	enzymes	enzyme	NNS
cord-295807-68sukdb1	378	9	,	,	,
cord-295807-68sukdb1	378	10	stimulate	stimulate	VBP
cord-295807-68sukdb1	378	11	downstream	downstream	JJ
cord-295807-68sukdb1	378	12	secretory	secretory	JJ
cord-295807-68sukdb1	378	13	processes	process	NNS
cord-295807-68sukdb1	378	14	,	,	,
cord-295807-68sukdb1	378	15	and	and	CC
cord-295807-68sukdb1	378	16	to	to	TO
cord-295807-68sukdb1	378	17	kill	kill	VB
cord-295807-68sukdb1	378	18	ingested	ingested	JJ
cord-295807-68sukdb1	378	19	pathogens	pathogen	NNS
cord-295807-68sukdb1	378	20	.	.	.
cord-295807-68sukdb1	379	1	It	-PRON-	PRP
cord-295807-68sukdb1	379	2	is	be	VBZ
cord-295807-68sukdb1	379	3	secreted	secrete	VBN
cord-295807-68sukdb1	379	4	by	by	IN
cord-295807-68sukdb1	379	5	parietal	parietal	JJ
cord-295807-68sukdb1	379	6	cells	cell	NNS
cord-295807-68sukdb1	379	7	using	use	VBG
cord-295807-68sukdb1	379	8	similar	similar	JJ
cord-295807-68sukdb1	379	9	transport	transport	NN
cord-295807-68sukdb1	379	10	mechanisms	mechanism	NNS
cord-295807-68sukdb1	379	11	employed	employ	VBN
cord-295807-68sukdb1	379	12	by	by	IN
cord-295807-68sukdb1	379	13	osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	379	14	(	(	-LRB-
cord-295807-68sukdb1	379	15	described	describe	VBN
cord-295807-68sukdb1	379	16	in	in	IN
cord-295807-68sukdb1	379	17	the	the	DT
cord-295807-68sukdb1	379	18	previous	previous	JJ
cord-295807-68sukdb1	379	19	section	section	NN
cord-295807-68sukdb1	379	20	)	)	-RRB-
cord-295807-68sukdb1	379	21	.	.	.
cord-295807-68sukdb1	380	1	Thus	thus	RB
cord-295807-68sukdb1	380	2	,	,	,
cord-295807-68sukdb1	380	3	the	the	DT
cord-295807-68sukdb1	380	4	secretion	secretion	NN
cord-295807-68sukdb1	380	5	of	of	IN
cord-295807-68sukdb1	380	6	acid	acid	NN
cord-295807-68sukdb1	380	7	across	across	IN
cord-295807-68sukdb1	380	8	the	the	DT
cord-295807-68sukdb1	380	9	apical	apical	JJ
cord-295807-68sukdb1	380	10	membrane	membrane	NN
cord-295807-68sukdb1	380	11	is	be	VBZ
cord-295807-68sukdb1	380	12	mediated	mediate	VBN
cord-295807-68sukdb1	380	13	by	by	IN
cord-295807-68sukdb1	380	14	a	a	DT
cord-295807-68sukdb1	380	15	H	h	NN
cord-295807-68sukdb1	380	16	+	+	CC
cord-295807-68sukdb1	380	17	/K	/K	.
cord-295807-68sukdb1	381	1	+	+	CC
cord-295807-68sukdb1	382	1	-ATPase	-ATPase	NNP
cord-295807-68sukdb1	383	1	and	and	CC
cord-295807-68sukdb1	383	2	is	be	VBZ
cord-295807-68sukdb1	383	3	balanced	balance	VBN
cord-295807-68sukdb1	383	4	by	by	IN
cord-295807-68sukdb1	383	5	the	the	DT
cord-295807-68sukdb1	383	6	extrusion	extrusion	NN
cord-295807-68sukdb1	383	7	of	of	IN
cord-295807-68sukdb1	383	8	HCO3into	HCO3into	NNP
cord-295807-68sukdb1	383	9	the	the	DT
cord-295807-68sukdb1	383	10	plasma	plasma	NN
cord-295807-68sukdb1	383	11	via	via	IN
cord-295807-68sukdb1	383	12	AE2	AE2	NNP
cord-295807-68sukdb1	383	13	(	(	-LRB-
cord-295807-68sukdb1	383	14	the	the	DT
cord-295807-68sukdb1	383	15	alkaline	alkaline	JJ
cord-295807-68sukdb1	383	16	tide	tide	NN
cord-295807-68sukdb1	383	17	associated	associate	VBN
cord-295807-68sukdb1	383	18	with	with	IN
cord-295807-68sukdb1	383	19	feeding	feed	VBG
cord-295807-68sukdb1	383	20	[	[	-LRB-
cord-295807-68sukdb1	383	21	59	59	CD
cord-295807-68sukdb1	383	22	,	,	,
cord-295807-68sukdb1	383	23	221	221	CD
cord-295807-68sukdb1	383	24	]	]	-RRB-
cord-295807-68sukdb1	383	25	,	,	,
cord-295807-68sukdb1	383	26	see	see	VB
cord-295807-68sukdb1	383	27	Figure	figure	NN
cord-295807-68sukdb1	383	28	9	9	CD
cord-295807-68sukdb1	383	29	)	)	-RRB-
cord-295807-68sukdb1	383	30	.	.	.
cord-295807-68sukdb1	384	1	Stomach	stomach	NN
cord-295807-68sukdb1	384	2	epithelia	epithelium	NNS
cord-295807-68sukdb1	384	3	are	be	VBP
cord-295807-68sukdb1	384	4	protected	protect	VBN
cord-295807-68sukdb1	384	5	from	from	IN
cord-295807-68sukdb1	384	6	acid	acid	JJ
cord-295807-68sukdb1	384	7	injury	injury	NN
cord-295807-68sukdb1	384	8	by	by	IN
cord-295807-68sukdb1	384	9	a	a	DT
cord-295807-68sukdb1	384	10	mucus	mucus	NN
cord-295807-68sukdb1	384	11	lining	lining	NN
cord-295807-68sukdb1	384	12	.	.	.
cord-295807-68sukdb1	385	1	The	the	DT
cord-295807-68sukdb1	385	2	pathogenic	pathogenic	JJ
cord-295807-68sukdb1	385	3	bacterium	bacterium	NN
cord-295807-68sukdb1	385	4	H.pylori	H.pylori	VBZ
cord-295807-68sukdb1	385	5	is	be	VBZ
cord-295807-68sukdb1	385	6	able	able	JJ
cord-295807-68sukdb1	385	7	to	to	TO
cord-295807-68sukdb1	385	8	survive	survive	VB
cord-295807-68sukdb1	385	9	in	in	IN
cord-295807-68sukdb1	385	10	gastric	gastric	JJ
cord-295807-68sukdb1	385	11	acid	acid	NN
cord-295807-68sukdb1	385	12	because	because	IN
cord-295807-68sukdb1	385	13	it	-PRON-	PRP
cord-295807-68sukdb1	385	14	can	can	MD
cord-295807-68sukdb1	385	15	take	take	VB
cord-295807-68sukdb1	385	16	up	up	RP
cord-295807-68sukdb1	385	17	urea	urea	NN
cord-295807-68sukdb1	385	18	from	from	IN
cord-295807-68sukdb1	385	19	its	-PRON-	PRP$
cord-295807-68sukdb1	385	20	environment	environment	NN
cord-295807-68sukdb1	385	21	,	,	,
cord-295807-68sukdb1	385	22	via	via	IN
cord-295807-68sukdb1	385	23	a	a	DT
cord-295807-68sukdb1	385	24	H	h	NN
cord-295807-68sukdb1	385	25	+	+	CC
cord-295807-68sukdb1	385	26	-gated	-gated	JJ
cord-295807-68sukdb1	385	27	urea	urea	NN
cord-295807-68sukdb1	385	28	channel	channel	NN
cord-295807-68sukdb1	385	29	,	,	,
cord-295807-68sukdb1	385	30	and	and	CC
cord-295807-68sukdb1	385	31	convert	convert	VB
cord-295807-68sukdb1	385	32	it	-PRON-	PRP
cord-295807-68sukdb1	385	33	into	into	IN
cord-295807-68sukdb1	385	34	NH3	NH3	NNP
cord-295807-68sukdb1	385	35	to	to	TO
cord-295807-68sukdb1	385	36	neutralize	neutralize	VB
cord-295807-68sukdb1	385	37	acid	acid	NN
cord-295807-68sukdb1	385	38	in	in	IN
cord-295807-68sukdb1	385	39	its	-PRON-	PRP$
cord-295807-68sukdb1	385	40	immediate	immediate	JJ
cord-295807-68sukdb1	385	41	environment	environment	NN
cord-295807-68sukdb1	385	42	[	[	-LRB-
cord-295807-68sukdb1	385	43	222	222	CD
cord-295807-68sukdb1	385	44	]	]	-RRB-
cord-295807-68sukdb1	385	45	.	.	.
cord-295807-68sukdb1	386	1	In	in	IN
cord-295807-68sukdb1	386	2	the	the	DT
cord-295807-68sukdb1	386	3	vicinity	vicinity	NN
cord-295807-68sukdb1	386	4	of	of	IN
cord-295807-68sukdb1	386	5	the	the	DT
cord-295807-68sukdb1	386	6	mucus	mucus	NN
cord-295807-68sukdb1	386	7	layer	layer	NN
cord-295807-68sukdb1	386	8	,	,	,
cord-295807-68sukdb1	386	9	this	this	DT
cord-295807-68sukdb1	386	10	action	action	NN
cord-295807-68sukdb1	386	11	causes	cause	VBZ
cord-295807-68sukdb1	386	12	H.pylori	h.pylori	VBP
cord-295807-68sukdb1	386	13	to	to	TO
cord-295807-68sukdb1	386	14	raise	raise	VB
cord-295807-68sukdb1	386	15	mucus	mucus	NN
cord-295807-68sukdb1	386	16	pH	ph	NN
cord-295807-68sukdb1	386	17	,	,	,
cord-295807-68sukdb1	386	18	lowering	lower	VBG
cord-295807-68sukdb1	386	19	its	-PRON-	PRP$
cord-295807-68sukdb1	386	20	viscoelasticity	viscoelasticity	NN
cord-295807-68sukdb1	386	21	,	,	,
cord-295807-68sukdb1	386	22	promoting	promote	VBG
cord-295807-68sukdb1	386	23	bacterial	bacterial	JJ
cord-295807-68sukdb1	386	24	infiltration	infiltration	NN
cord-295807-68sukdb1	386	25	,	,	,
cord-295807-68sukdb1	386	26	and	and	CC
cord-295807-68sukdb1	386	27	ultimately	ultimately	RB
cord-295807-68sukdb1	386	28	resulting	result	VBG
cord-295807-68sukdb1	386	29	in	in	IN
cord-295807-68sukdb1	386	30	inflammation	inflammation	NN
cord-295807-68sukdb1	386	31	,	,	,
cord-295807-68sukdb1	386	32	ulceration	ulceration	NN
cord-295807-68sukdb1	386	33	[	[	-LRB-
cord-295807-68sukdb1	386	34	223	223	CD
cord-295807-68sukdb1	386	35	]	]	-RRB-
cord-295807-68sukdb1	386	36	,	,	,
cord-295807-68sukdb1	386	37	and	and	CC
cord-295807-68sukdb1	386	38	risk	risk	NN
cord-295807-68sukdb1	386	39	of	of	IN
cord-295807-68sukdb1	386	40	gastric	gastric	JJ
cord-295807-68sukdb1	386	41	cancer	cancer	NN
cord-295807-68sukdb1	386	42	[	[	-LRB-
cord-295807-68sukdb1	386	43	224	224	CD
cord-295807-68sukdb1	386	44	]	]	-RRB-
cord-295807-68sukdb1	386	45	.	.	.
cord-295807-68sukdb1	387	1	Another	another	DT
cord-295807-68sukdb1	387	2	condition	condition	NN
cord-295807-68sukdb1	387	3	,	,	,
cord-295807-68sukdb1	387	4	gastroesophageal	gastroesophageal	JJ
cord-295807-68sukdb1	387	5	reflux	reflux	NN
cord-295807-68sukdb1	387	6	disease	disease	NN
cord-295807-68sukdb1	387	7	,	,	,
cord-295807-68sukdb1	387	8	is	be	VBZ
cord-295807-68sukdb1	387	9	caused	cause	VBN
cord-295807-68sukdb1	387	10	by	by	IN
cord-295807-68sukdb1	387	11	reflux	reflux	NN
cord-295807-68sukdb1	387	12	of	of	IN
cord-295807-68sukdb1	387	13	gastric	gastric	JJ
cord-295807-68sukdb1	387	14	acid	acid	NN
cord-295807-68sukdb1	387	15	into	into	IN
cord-295807-68sukdb1	387	16	the	the	DT
cord-295807-68sukdb1	387	17	esophagus	esophagus	NN
cord-295807-68sukdb1	387	18	and	and	CC
cord-295807-68sukdb1	387	19	can	can	MD
cord-295807-68sukdb1	387	20	cause	cause	VB
cord-295807-68sukdb1	387	21	heartburn	heartburn	NN
cord-295807-68sukdb1	387	22	and	and	CC
cord-295807-68sukdb1	387	23	,	,	,
cord-295807-68sukdb1	387	24	in	in	IN
cord-295807-68sukdb1	387	25	severe	severe	JJ
cord-295807-68sukdb1	387	26	cases	case	NNS
cord-295807-68sukdb1	387	27	,	,	,
cord-295807-68sukdb1	387	28	can	can	MD
cord-295807-68sukdb1	387	29	lead	lead	VB
cord-295807-68sukdb1	387	30	to	to	IN
cord-295807-68sukdb1	387	31	esophageal	esophageal	JJ
cord-295807-68sukdb1	387	32	damage	damage	NN
cord-295807-68sukdb1	387	33	.	.	.
cord-295807-68sukdb1	388	1	Salivary	Salivary	NNP
cord-295807-68sukdb1	388	2	HCO3plays	HCO3plays	NNP
cord-295807-68sukdb1	389	1	an	an	DT
cord-295807-68sukdb1	389	2	important	important	JJ
cord-295807-68sukdb1	389	3	role	role	NN
cord-295807-68sukdb1	389	4	in	in	IN
cord-295807-68sukdb1	389	5	esophageal	esophageal	JJ
cord-295807-68sukdb1	389	6	acid	acid	NN
cord-295807-68sukdb1	389	7	defense	defense	NN
cord-295807-68sukdb1	389	8	[	[	-LRB-
cord-295807-68sukdb1	389	9	225	225	CD
cord-295807-68sukdb1	389	10	]	]	-RRB-
cord-295807-68sukdb1	389	11	[	[	-LRB-
cord-295807-68sukdb1	389	12	226	226	CD
cord-295807-68sukdb1	389	13	]	]	-RRB-
cord-295807-68sukdb1	389	14	[	[	-LRB-
cord-295807-68sukdb1	389	15	227	227	CD
cord-295807-68sukdb1	389	16	]	]	-RRB-
cord-295807-68sukdb1	389	17	by	by	IN
cord-295807-68sukdb1	389	18	neutralizing	neutralize	VBG
cord-295807-68sukdb1	389	19	gastric	gastric	JJ
cord-295807-68sukdb1	389	20	acid	acid	NN
cord-295807-68sukdb1	389	21	[	[	-LRB-
cord-295807-68sukdb1	389	22	228	228	CD
cord-295807-68sukdb1	389	23	]	]	-RRB-
cord-295807-68sukdb1	389	24	.	.	.
cord-295807-68sukdb1	390	1	Conversely	conversely	RB
cord-295807-68sukdb1	390	2	,	,	,
cord-295807-68sukdb1	390	3	the	the	DT
cord-295807-68sukdb1	390	4	action	action	NN
cord-295807-68sukdb1	390	5	of	of	IN
cord-295807-68sukdb1	390	6	NHE1	NHE1	NNP
cord-295807-68sukdb1	390	7	in	in	IN
cord-295807-68sukdb1	390	8	esophageal	esophageal	JJ
cord-295807-68sukdb1	390	9	epithelia	epithelium	NNS
cord-295807-68sukdb1	390	10	may	may	MD
cord-295807-68sukdb1	390	11	exacerbate	exacerbate	VB
cord-295807-68sukdb1	390	12	the	the	DT
cord-295807-68sukdb1	390	13	damage	damage	NN
cord-295807-68sukdb1	390	14	,	,	,
cord-295807-68sukdb1	390	15	perhaps	perhaps	RB
cord-295807-68sukdb1	390	16	by	by	IN
cord-295807-68sukdb1	390	17	indirectly	indirectly	RB
cord-295807-68sukdb1	390	18	stimulating	stimulate	VBG
cord-295807-68sukdb1	390	19	pro	pro	JJ
cord-295807-68sukdb1	390	20	-	-	JJ
cord-295807-68sukdb1	390	21	apoptotic	apoptotic	JJ
cord-295807-68sukdb1	390	22	pathways	pathway	NNS
cord-295807-68sukdb1	390	23	[	[	-LRB-
cord-295807-68sukdb1	390	24	229	229	CD
cord-295807-68sukdb1	390	25	]	]	-RRB-
cord-295807-68sukdb1	390	26	.	.	.
cord-295807-68sukdb1	391	1	Acid	acid	JJ
cord-295807-68sukdb1	391	2	reflux	reflux	NN
cord-295807-68sukdb1	391	3	symptoms	symptom	NNS
cord-295807-68sukdb1	391	4	can	can	MD
cord-295807-68sukdb1	391	5	be	be	VB
cord-295807-68sukdb1	391	6	relieved	relieve	VBN
cord-295807-68sukdb1	391	7	by	by	IN
cord-295807-68sukdb1	391	8	neutralizing	neutralize	VBG
cord-295807-68sukdb1	391	9	gastric	gastric	JJ
cord-295807-68sukdb1	391	10	acid	acid	NN
cord-295807-68sukdb1	391	11	with	with	IN
cord-295807-68sukdb1	391	12	antacids	antacid	NNS
cord-295807-68sukdb1	391	13	,	,	,
cord-295807-68sukdb1	391	14	which	which	WDT
cord-295807-68sukdb1	391	15	at	at	IN
cord-295807-68sukdb1	391	16	their	-PRON-	PRP$
cord-295807-68sukdb1	391	17	simplest	simple	JJS
cord-295807-68sukdb1	391	18	are	be	VBP
cord-295807-68sukdb1	391	19	just	just	RB
cord-295807-68sukdb1	391	20	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	391	21	or	or	CC
cord-295807-68sukdb1	391	22	carbonate	carbonate	NN
cord-295807-68sukdb1	391	23	salts	salt	NNS
cord-295807-68sukdb1	391	24	(	(	-LRB-
cord-295807-68sukdb1	391	25	e.g.	e.g.	RB
cord-295807-68sukdb1	391	26	,	,	,
cord-295807-68sukdb1	391	27	TUMS	TUMS	NNP
cord-295807-68sukdb1	391	28	®	®	VBP
cord-295807-68sukdb1	391	29	is	be	VBZ
cord-295807-68sukdb1	391	30	calcium	calcium	NN
cord-295807-68sukdb1	391	31	carbonate	carbonate	NN
cord-295807-68sukdb1	391	32	)	)	-RRB-
cord-295807-68sukdb1	391	33	.	.	.
cord-295807-68sukdb1	392	1	However	however	RB
cord-295807-68sukdb1	392	2	,	,	,
cord-295807-68sukdb1	392	3	an	an	DT
cord-295807-68sukdb1	392	4	early	early	JJ
cord-295807-68sukdb1	392	5	antacid	antacid	JJ
cord-295807-68sukdb1	392	6	regimen	regimen	NN
cord-295807-68sukdb1	392	7	for	for	IN
cord-295807-68sukdb1	392	8	peptic	peptic	JJ
cord-295807-68sukdb1	392	9	ulcers	ulcer	NNS
cord-295807-68sukdb1	392	10	,	,	,
cord-295807-68sukdb1	392	11	based	base	VBN
cord-295807-68sukdb1	392	12	on	on	IN
cord-295807-68sukdb1	392	13	administration	administration	NN
cord-295807-68sukdb1	392	14	of	of	IN
cord-295807-68sukdb1	392	15	milk	milk	NN
cord-295807-68sukdb1	392	16	and	and	CC
cord-295807-68sukdb1	392	17	CaCO3	CaCO3	NNP
cord-295807-68sukdb1	392	18	and	and	CC
cord-295807-68sukdb1	392	19	still	still	RB
cord-295807-68sukdb1	392	20	observed	observe	VBD
cord-295807-68sukdb1	392	21	in	in	IN
cord-295807-68sukdb1	392	22	the	the	DT
cord-295807-68sukdb1	392	23	modern	modern	JJ
cord-295807-68sukdb1	392	24	age	age	NN
cord-295807-68sukdb1	392	25	in	in	IN
cord-295807-68sukdb1	392	26	self	self	NN
cord-295807-68sukdb1	392	27	-	-	HYPH
cord-295807-68sukdb1	392	28	medicating	medicate	VBG
cord-295807-68sukdb1	392	29	individuals	individual	NNS
cord-295807-68sukdb1	392	30	,	,	,
cord-295807-68sukdb1	392	31	results	result	NNS
cord-295807-68sukdb1	392	32	in	in	IN
cord-295807-68sukdb1	392	33	adverse	adverse	JJ
cord-295807-68sukdb1	392	34	outcomes	outcome	NNS
cord-295807-68sukdb1	392	35	:	:	:
cord-295807-68sukdb1	392	36	the	the	DT
cord-295807-68sukdb1	392	37	so	so	RB
cord-295807-68sukdb1	392	38	-	-	HYPH
cord-295807-68sukdb1	392	39	called	call	VBN
cord-295807-68sukdb1	392	40	'	'	``
cord-295807-68sukdb1	392	41	milk	milk	NN
cord-295807-68sukdb1	392	42	-	-	HYPH
cord-295807-68sukdb1	392	43	alkali	alkali	NN
cord-295807-68sukdb1	392	44	syndrome	syndrome	NN
cord-295807-68sukdb1	392	45	'	'	''
cord-295807-68sukdb1	392	46	characterized	characterize	VBN
cord-295807-68sukdb1	392	47	by	by	IN
cord-295807-68sukdb1	392	48	MAlk	MAlk	NNS
cord-295807-68sukdb1	392	49	and	and	CC
cord-295807-68sukdb1	392	50	hypercalcemia	hypercalcemia	NN
cord-295807-68sukdb1	392	51	[	[	-LRB-
cord-295807-68sukdb1	392	52	230	230	CD
cord-295807-68sukdb1	392	53	,	,	,
cord-295807-68sukdb1	392	54	231	231	CD
cord-295807-68sukdb1	392	55	]	]	-RRB-
cord-295807-68sukdb1	392	56	.	.	.
cord-295807-68sukdb1	393	1	An	an	DT
cord-295807-68sukdb1	393	2	alternative	alternative	JJ
cord-295807-68sukdb1	393	3	approach	approach	NN
cord-295807-68sukdb1	393	4	to	to	IN
cord-295807-68sukdb1	393	5	lowering	lower	VBG
cord-295807-68sukdb1	393	6	gastric	gastric	JJ
cord-295807-68sukdb1	393	7	pH	ph	NN
cord-295807-68sukdb1	393	8	is	be	VBZ
cord-295807-68sukdb1	393	9	to	to	TO
cord-295807-68sukdb1	393	10	use	use	VB
cord-295807-68sukdb1	393	11	PPIs	ppi	NNS
cord-295807-68sukdb1	393	12	or	or	CC
cord-295807-68sukdb1	393	13	H2-receptor	h2-receptor	NN
cord-295807-68sukdb1	393	14	agonists	agonist	NNS
cord-295807-68sukdb1	393	15	which	which	WDT
cord-295807-68sukdb1	393	16	dampen	dampen	VBP
cord-295807-68sukdb1	393	17	the	the	DT
cord-295807-68sukdb1	393	18	signaling	signal	VBG
cord-295807-68sukdb1	393	19	pathways	pathway	NNS
cord-295807-68sukdb1	393	20	that	that	WDT
cord-295807-68sukdb1	393	21	stimulate	stimulate	VBP
cord-295807-68sukdb1	393	22	H	h	NN
cord-295807-68sukdb1	393	23	+	+	CC
cord-295807-68sukdb1	393	24	secretion	secretion	NN
cord-295807-68sukdb1	393	25	.	.	.
cord-295807-68sukdb1	394	1	H2	H2	NNP
cord-295807-68sukdb1	394	2	agonists	agonist	NNS
cord-295807-68sukdb1	394	3	,	,	,
cord-295807-68sukdb1	394	4	in	in	IN
cord-295807-68sukdb1	394	5	addition	addition	NN
cord-295807-68sukdb1	394	6	,	,	,
cord-295807-68sukdb1	394	7	therapeutically	therapeutically	RB
cord-295807-68sukdb1	394	8	lower	low	JJR
cord-295807-68sukdb1	394	9	the	the	DT
cord-295807-68sukdb1	394	10	activity	activity	NN
cord-295807-68sukdb1	394	11	of	of	IN
cord-295807-68sukdb1	394	12	esophageal	esophageal	JJ
cord-295807-68sukdb1	394	13	NHE1	NHE1	NNP
cord-295807-68sukdb1	394	14	[	[	-LRB-
cord-295807-68sukdb1	394	15	232	232	CD
cord-295807-68sukdb1	394	16	]	]	-RRB-
cord-295807-68sukdb1	394	17	.	.	.
cord-295807-68sukdb1	395	1	Some	some	DT
cord-295807-68sukdb1	395	2	over	over	IN
cord-295807-68sukdb1	395	3	-	-	HYPH
cord-295807-68sukdb1	395	4	the	the	DT
cord-295807-68sukdb1	395	5	-	-	HYPH
cord-295807-68sukdb1	395	6	counter	counter	NN
cord-295807-68sukdb1	395	7	formulations	formulation	NNS
cord-295807-68sukdb1	395	8	combine	combine	VBP
cord-295807-68sukdb1	395	9	these	these	DT
cord-295807-68sukdb1	395	10	drugs	drug	NNS
cord-295807-68sukdb1	395	11	with	with	IN
cord-295807-68sukdb1	395	12	an	an	DT
cord-295807-68sukdb1	395	13	antacid	antacid	NN
cord-295807-68sukdb1	395	14	to	to	TO
cord-295807-68sukdb1	395	15	lower	lower	VB
cord-295807-68sukdb1	395	16	the	the	DT
cord-295807-68sukdb1	395	17	dose	dose	NN
cord-295807-68sukdb1	395	18	of	of	IN
cord-295807-68sukdb1	395	19	each	each	DT
cord-295807-68sukdb1	395	20	and	and	CC
cord-295807-68sukdb1	395	21	minimize	minimize	VB
cord-295807-68sukdb1	395	22	side	side	JJ
cord-295807-68sukdb1	395	23	effects	effect	NNS
cord-295807-68sukdb1	395	24	of	of	IN
cord-295807-68sukdb1	395	25	each	each	DT
cord-295807-68sukdb1	395	26	such	such	JJ
cord-295807-68sukdb1	395	27	as	as	IN
cord-295807-68sukdb1	395	28	bloating	bloating	NN
cord-295807-68sukdb1	395	29	(	(	-LRB-
cord-295807-68sukdb1	395	30	from	from	IN
cord-295807-68sukdb1	395	31	gastric	gastric	JJ
cord-295807-68sukdb1	395	32	CO2	CO2	NNP
cord-295807-68sukdb1	395	33	generation	generation	NN
cord-295807-68sukdb1	395	34	)	)	-RRB-
cord-295807-68sukdb1	395	35	and	and	CC
cord-295807-68sukdb1	395	36	osteoporosis	osteoporosis	NN
cord-295807-68sukdb1	395	37	(	(	-LRB-
cord-295807-68sukdb1	395	38	from	from	IN
cord-295807-68sukdb1	395	39	chronic	chronic	JJ
cord-295807-68sukdb1	395	40	inhibition	inhibition	NN
cord-295807-68sukdb1	395	41	of	of	IN
cord-295807-68sukdb1	395	42	intestinal	intestinal	JJ
cord-295807-68sukdb1	396	1	Ca	ca	NN
cord-295807-68sukdb1	396	2	2	2	CD
cord-295807-68sukdb1	396	3	+	+	CC
cord-295807-68sukdb1	396	4	reabsorption	reabsorption	NN
cord-295807-68sukdb1	396	5	,	,	,
cord-295807-68sukdb1	396	6	see	see	VB
cord-295807-68sukdb1	396	7	section	section	NN
cord-295807-68sukdb1	396	8	4.6	4.6	CD
cord-295807-68sukdb1	396	9	)	)	-RRB-
cord-295807-68sukdb1	396	10	.	.	.
cord-295807-68sukdb1	397	1	Orally	orally	RB
cord-295807-68sukdb1	397	2	-	-	HYPH
cord-295807-68sukdb1	397	3	dosed	dose	VBN
cord-295807-68sukdb1	397	4	acid	acid	NN
cord-295807-68sukdb1	397	5	-	-	HYPH
cord-295807-68sukdb1	397	6	chelators	chelator	NNS
cord-295807-68sukdb1	397	7	such	such	JJ
cord-295807-68sukdb1	397	8	as	as	IN
cord-295807-68sukdb1	397	9	veverimer	veverimer	NNP
cord-295807-68sukdb1	397	10	,	,	,
cord-295807-68sukdb1	397	11	also	also	RB
cord-295807-68sukdb1	397	12	raise	raise	VB
cord-295807-68sukdb1	397	13	gastric	gastric	JJ
cord-295807-68sukdb1	397	14	acid	acid	NN
cord-295807-68sukdb1	397	15	pH	ph	NN
cord-295807-68sukdb1	397	16	[	[	-LRB-
cord-295807-68sukdb1	397	17	233	233	CD
cord-295807-68sukdb1	397	18	]	]	-RRB-
cord-295807-68sukdb1	397	19	but	but	CC
cord-295807-68sukdb1	397	20	have	have	VBP
cord-295807-68sukdb1	397	21	not	not	RB
cord-295807-68sukdb1	397	22	been	be	VBN
cord-295807-68sukdb1	397	23	tested	test	VBN
cord-295807-68sukdb1	397	24	as	as	IN
cord-295807-68sukdb1	397	25	a	a	DT
cord-295807-68sukdb1	397	26	therapy	therapy	NN
cord-295807-68sukdb1	397	27	for	for	IN
cord-295807-68sukdb1	397	28	heartburn	heartburn	NN
cord-295807-68sukdb1	397	29	.	.	.
cord-295807-68sukdb1	398	1	The	the	DT
cord-295807-68sukdb1	398	2	achlorhydric	achlorhydric	JJ
cord-295807-68sukdb1	398	3	phenotype	phenotype	NN
cord-295807-68sukdb1	398	4	of	of	IN
cord-295807-68sukdb1	398	5	Ae2-null	Ae2-null	NNP
cord-295807-68sukdb1	398	6	mice	mouse	NNS
cord-295807-68sukdb1	398	7	suggests	suggest	VBZ
cord-295807-68sukdb1	398	8	that	that	IN
cord-295807-68sukdb1	398	9	AE2	AE2	NNP
cord-295807-68sukdb1	398	10	blockage	blockage	NN
cord-295807-68sukdb1	398	11	may	may	MD
cord-295807-68sukdb1	398	12	have	have	VB
cord-295807-68sukdb1	398	13	potential	potential	NN
cord-295807-68sukdb1	398	14	as	as	IN
cord-295807-68sukdb1	398	15	a	a	DT
cord-295807-68sukdb1	398	16	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	398	17	target	target	NN
cord-295807-68sukdb1	398	18	[	[	-LRB-
cord-295807-68sukdb1	398	19	234	234	CD
cord-295807-68sukdb1	398	20	]	]	-RRB-
cord-295807-68sukdb1	398	21	.	.	.
cord-295807-68sukdb1	399	1	PPIs	ppi	NNS
cord-295807-68sukdb1	399	2	in	in	IN
cord-295807-68sukdb1	399	3	combination	combination	NN
cord-295807-68sukdb1	399	4	with	with	IN
cord-295807-68sukdb1	399	5	antibiotics	antibiotic	NNS
cord-295807-68sukdb1	399	6	are	be	VBP
cord-295807-68sukdb1	399	7	used	use	VBN
cord-295807-68sukdb1	399	8	to	to	TO
cord-295807-68sukdb1	399	9	treat	treat	VB
cord-295807-68sukdb1	399	10	H.pylori	h.pylori	JJ
cord-295807-68sukdb1	399	11	infections	infection	NNS
cord-295807-68sukdb1	399	12	:	:	:
cord-295807-68sukdb1	399	13	it	-PRON-	PRP
cord-295807-68sukdb1	399	14	has	have	VBZ
cord-295807-68sukdb1	399	15	been	be	VBN
cord-295807-68sukdb1	399	16	proposed	propose	VBN
cord-295807-68sukdb1	399	17	that	that	IN
cord-295807-68sukdb1	399	18	raising	raise	VBG
cord-295807-68sukdb1	399	19	stomach	stomach	NN
cord-295807-68sukdb1	399	20	pH	ph	NN
cord-295807-68sukdb1	399	21	permits	permit	NNS
cord-295807-68sukdb1	399	22	faster	fast	JJR
cord-295807-68sukdb1	399	23	bacterial	bacterial	JJ
cord-295807-68sukdb1	399	24	growth	growth	NN
cord-295807-68sukdb1	399	25	,	,	,
cord-295807-68sukdb1	399	26	potentiating	potentiate	VBG
cord-295807-68sukdb1	399	27	the	the	DT
cord-295807-68sukdb1	399	28	effects	effect	NNS
cord-295807-68sukdb1	399	29	of	of	IN
cord-295807-68sukdb1	399	30	antibiotics	antibiotic	NNS
cord-295807-68sukdb1	399	31	that	that	WDT
cord-295807-68sukdb1	399	32	act	act	VBP
cord-295807-68sukdb1	399	33	on	on	IN
cord-295807-68sukdb1	399	34	dividing	divide	VBG
cord-295807-68sukdb1	399	35	bacteria	bacteria	NNS
cord-295807-68sukdb1	399	36	[	[	-LRB-
cord-295807-68sukdb1	399	37	235	235	CD
cord-295807-68sukdb1	399	38	]	]	-RRB-
cord-295807-68sukdb1	399	39	.	.	.
cord-295807-68sukdb1	400	1	Inhibitors	inhibitor	NNS
cord-295807-68sukdb1	400	2	of	of	IN
cord-295807-68sukdb1	400	3	the	the	DT
cord-295807-68sukdb1	400	4	urease	urease	NN
cord-295807-68sukdb1	400	5	and	and	CC
cord-295807-68sukdb1	400	6	H	h	NN
cord-295807-68sukdb1	400	7	+	+	CC
cord-295807-68sukdb1	400	8	-gated	-gated	JJ
cord-295807-68sukdb1	400	9	urea	urea	NN
cord-295807-68sukdb1	400	10	transporter	transporter	NN
cord-295807-68sukdb1	400	11	of	of	IN
cord-295807-68sukdb1	400	12	H.pylori	H.pylori	NNS
cord-295807-68sukdb1	400	13	are	be	VBP
cord-295807-68sukdb1	400	14	potential	potential	JJ
cord-295807-68sukdb1	400	15	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	400	16	modalities	modality	NNS
cord-295807-68sukdb1	400	17	that	that	WDT
cord-295807-68sukdb1	400	18	remain	remain	VBP
cord-295807-68sukdb1	400	19	in	in	IN
cord-295807-68sukdb1	400	20	development	development	NN
cord-295807-68sukdb1	400	21	[	[	-LRB-
cord-295807-68sukdb1	400	22	236	236	CD
cord-295807-68sukdb1	400	23	]	]	-RRB-
cord-295807-68sukdb1	400	24	.	.	.
cord-295807-68sukdb1	401	1	The	the	DT
cord-295807-68sukdb1	401	2	exocrine	exocrine	JJ
cord-295807-68sukdb1	401	3	pancreas	pancreas	NN
cord-295807-68sukdb1	401	4	secretes	secrete	VBZ
cord-295807-68sukdb1	401	5	a	a	DT
cord-295807-68sukdb1	401	6	HCO3	HCO3	NNP
cord-295807-68sukdb1	401	7	--rich	--rich	NN
cord-295807-68sukdb1	401	8	fluid	fluid	NN
cord-295807-68sukdb1	401	9	that	that	WDT
cord-295807-68sukdb1	401	10	is	be	VBZ
cord-295807-68sukdb1	401	11	vital	vital	JJ
cord-295807-68sukdb1	401	12	for	for	IN
cord-295807-68sukdb1	401	13	neutralizing	neutralize	VBG
cord-295807-68sukdb1	401	14	gastric	gastric	JJ
cord-295807-68sukdb1	401	15	juices	juice	NNS
cord-295807-68sukdb1	401	16	passing	pass	VBG
cord-295807-68sukdb1	401	17	into	into	IN
cord-295807-68sukdb1	401	18	the	the	DT
cord-295807-68sukdb1	401	19	duodenum	duodenum	NN
cord-295807-68sukdb1	401	20	.	.	.
cord-295807-68sukdb1	402	1	The	the	DT
cord-295807-68sukdb1	402	2	alkaline	alkaline	JJ
cord-295807-68sukdb1	402	3	pH	ph	NN
cord-295807-68sukdb1	402	4	of	of	IN
cord-295807-68sukdb1	402	5	pancreatic	pancreatic	JJ
cord-295807-68sukdb1	402	6	juice	juice	NN
cord-295807-68sukdb1	402	7	holds	hold	VBZ
cord-295807-68sukdb1	402	8	digestive	digestive	JJ
cord-295807-68sukdb1	402	9	enzymes	enzyme	NNS
cord-295807-68sukdb1	402	10	such	such	JJ
cord-295807-68sukdb1	402	11	as	as	IN
cord-295807-68sukdb1	402	12	amylase	amylase	NN
cord-295807-68sukdb1	402	13	and	and	CC
cord-295807-68sukdb1	402	14	lipase	lipase	NN
cord-295807-68sukdb1	402	15	in	in	IN
cord-295807-68sukdb1	402	16	an	an	DT
cord-295807-68sukdb1	402	17	inactive	inactive	JJ
cord-295807-68sukdb1	402	18	state	state	NN
cord-295807-68sukdb1	402	19	until	until	IN
cord-295807-68sukdb1	402	20	the	the	DT
cord-295807-68sukdb1	402	21	secreted	secrete	VBN
cord-295807-68sukdb1	402	22	fluid	fluid	NN
cord-295807-68sukdb1	402	23	is	be	VBZ
cord-295807-68sukdb1	402	24	neutralized	neutralize	VBN
cord-295807-68sukdb1	402	25	in	in	IN
cord-295807-68sukdb1	402	26	the	the	DT
cord-295807-68sukdb1	402	27	duodenal	duodenal	JJ
cord-295807-68sukdb1	402	28	lumen	lumen	NN
cord-295807-68sukdb1	402	29	by	by	IN
cord-295807-68sukdb1	402	30	chyme	chyme	NNS
cord-295807-68sukdb1	402	31	,	,	,
cord-295807-68sukdb1	402	32	preventing	prevent	VBG
cord-295807-68sukdb1	402	33	damage	damage	NN
cord-295807-68sukdb1	402	34	to	to	IN
cord-295807-68sukdb1	402	35	the	the	DT
cord-295807-68sukdb1	402	36	pancreatic	pancreatic	JJ
cord-295807-68sukdb1	402	37	ducts	duct	NNS
cord-295807-68sukdb1	402	38	.	.	.
cord-295807-68sukdb1	403	1	In	in	IN
cord-295807-68sukdb1	403	2	CF	CF	NNP
cord-295807-68sukdb1	403	3	,	,	,
cord-295807-68sukdb1	403	4	duodenal	duodenal	JJ
cord-295807-68sukdb1	403	5	hyperacidity	hyperacidity	NN
cord-295807-68sukdb1	403	6	also	also	RB
cord-295807-68sukdb1	403	7	holds	hold	VBZ
cord-295807-68sukdb1	403	8	pancreatic	pancreatic	JJ
cord-295807-68sukdb1	403	9	enzymes	enzyme	NNS
cord-295807-68sukdb1	403	10	in	in	IN
cord-295807-68sukdb1	403	11	an	an	DT
cord-295807-68sukdb1	403	12	inactive	inactive	JJ
cord-295807-68sukdb1	403	13	state	state	NN
cord-295807-68sukdb1	403	14	,	,	,
cord-295807-68sukdb1	403	15	but	but	CC
cord-295807-68sukdb1	403	16	without	without	IN
cord-295807-68sukdb1	403	17	the	the	DT
cord-295807-68sukdb1	403	18	neutralization	neutralization	NN
cord-295807-68sukdb1	403	19	of	of	IN
cord-295807-68sukdb1	403	20	chyme	chyme	NNS
cord-295807-68sukdb1	403	21	,	,	,
cord-295807-68sukdb1	403	22	they	-PRON-	PRP
cord-295807-68sukdb1	403	23	are	be	VBP
cord-295807-68sukdb1	403	24	not	not	RB
cord-295807-68sukdb1	403	25	even	even	RB
cord-295807-68sukdb1	403	26	active	active	JJ
cord-295807-68sukdb1	403	27	in	in	IN
cord-295807-68sukdb1	403	28	the	the	DT
cord-295807-68sukdb1	403	29	duodenum	duodenum	NN
cord-295807-68sukdb1	403	30	leading	lead	VBG
cord-295807-68sukdb1	403	31	to	to	IN
cord-295807-68sukdb1	403	32	malabsorption	malabsorption	NN
cord-295807-68sukdb1	403	33	of	of	IN
cord-295807-68sukdb1	403	34	nutrients	nutrient	NNS
cord-295807-68sukdb1	403	35	such	such	JJ
cord-295807-68sukdb1	403	36	as	as	IN
cord-295807-68sukdb1	403	37	lipids	lipid	NNS
cord-295807-68sukdb1	403	38	[	[	-LRB-
cord-295807-68sukdb1	403	39	237	237	CD
cord-295807-68sukdb1	403	40	]	]	-RRB-
cord-295807-68sukdb1	403	41	.	.	.
cord-295807-68sukdb1	404	1	All	all	RB
cord-295807-68sukdb1	404	2	along	along	IN
cord-295807-68sukdb1	404	3	the	the	DT
cord-295807-68sukdb1	404	4	intestine	intestine	NN
cord-295807-68sukdb1	404	5	,	,	,
cord-295807-68sukdb1	404	6	HCO3	HCO3	NNP
cord-295807-68sukdb1	404	7	--containing	--containe	VBG
cord-295807-68sukdb1	404	8	fluid	fluid	JJ
cord-295807-68sukdb1	404	9	secretions	secretion	NNS
cord-295807-68sukdb1	404	10	are	be	VBP
cord-295807-68sukdb1	404	11	required	require	VBN
cord-295807-68sukdb1	404	12	to	to	TO
cord-295807-68sukdb1	404	13	promote	promote	VB
cord-295807-68sukdb1	404	14	gastric	gastric	JJ
cord-295807-68sukdb1	404	15	motility	motility	NN
cord-295807-68sukdb1	404	16	.	.	.
cord-295807-68sukdb1	405	1	The	the	DT
cord-295807-68sukdb1	405	2	loss	loss	NN
cord-295807-68sukdb1	405	3	of	of	IN
cord-295807-68sukdb1	405	4	this	this	DT
cord-295807-68sukdb1	405	5	fluid	fluid	NN
cord-295807-68sukdb1	405	6	in	in	IN
cord-295807-68sukdb1	405	7	feces	fece	NNS
cord-295807-68sukdb1	405	8	represents	represent	VBZ
cord-295807-68sukdb1	405	9	a	a	DT
cord-295807-68sukdb1	405	10	substantial	substantial	JJ
cord-295807-68sukdb1	405	11	acid	acid	NN
cord-295807-68sukdb1	405	12	load	load	NN
cord-295807-68sukdb1	405	13	.	.	.
cord-295807-68sukdb1	406	1	Consequently	consequently	RB
cord-295807-68sukdb1	406	2	,	,	,
cord-295807-68sukdb1	406	3	CFTR	CFTR	NNP
cord-295807-68sukdb1	406	4	mutations	mutation	NNS
cord-295807-68sukdb1	406	5	result	result	VBP
cord-295807-68sukdb1	406	6	in	in	IN
cord-295807-68sukdb1	406	7	intestinal	intestinal	JJ
cord-295807-68sukdb1	406	8	blockage	blockage	NN
cord-295807-68sukdb1	406	9	[	[	-LRB-
cord-295807-68sukdb1	406	10	238	238	CD
cord-295807-68sukdb1	406	11	]	]	-RRB-
cord-295807-68sukdb1	406	12	and	and	CC
cord-295807-68sukdb1	406	13	secretory	secretory	JJ
cord-295807-68sukdb1	406	14	diarrhea	diarrhea	NN
cord-295807-68sukdb1	406	15	can	can	MD
cord-295807-68sukdb1	406	16	result	result	VB
cord-295807-68sukdb1	406	17	in	in	IN
cord-295807-68sukdb1	406	18	MAc	MAc	NNP
cord-295807-68sukdb1	406	19	[	[	-LRB-
cord-295807-68sukdb1	406	20	239	239	CD
cord-295807-68sukdb1	406	21	]	]	-RRB-
cord-295807-68sukdb1	406	22	.	.	.
cord-295807-68sukdb1	407	1	Balancing	balance	VBG
cord-295807-68sukdb1	407	2	secretory	secretory	NN
cord-295807-68sukdb1	407	3	processes	process	NNS
cord-295807-68sukdb1	407	4	,	,	,
cord-295807-68sukdb1	407	5	NHE3	NHE3	NNP
cord-295807-68sukdb1	407	6	and	and	CC
cord-295807-68sukdb1	407	7	SLC26A3	SLC26A3	NNP
cord-295807-68sukdb1	407	8	promote	promote	VBP
cord-295807-68sukdb1	407	9	fluid	fluid	JJ
cord-295807-68sukdb1	407	10	reabsorption	reabsorption	NN
cord-295807-68sukdb1	407	11	(	(	-LRB-
cord-295807-68sukdb1	407	12	Figure	figure	NN
cord-295807-68sukdb1	407	13	10	10	CD
cord-295807-68sukdb1	407	14	)	)	-RRB-
cord-295807-68sukdb1	407	15	.	.	.
cord-295807-68sukdb1	408	1	Accordingly	accordingly	RB
cord-295807-68sukdb1	408	2	,	,	,
cord-295807-68sukdb1	408	3	downregulation	downregulation	NN
cord-295807-68sukdb1	408	4	of	of	IN
cord-295807-68sukdb1	408	5	intestinal	intestinal	JJ
cord-295807-68sukdb1	408	6	NHE3	NHE3	NNP
cord-295807-68sukdb1	408	7	by	by	IN
cord-295807-68sukdb1	408	8	the	the	DT
cord-295807-68sukdb1	408	9	enterotoxigenic	enterotoxigenic	NNP
cord-295807-68sukdb1	408	10	bacteria	bacteria	NNS
cord-295807-68sukdb1	408	11	(	(	-LRB-
cord-295807-68sukdb1	408	12	E.coli	E.coli	NNS
cord-295807-68sukdb1	408	13	and	and	CC
cord-295807-68sukdb1	408	14	C.difficile	C.difficile	NNP
cord-295807-68sukdb1	408	15	)	)	-RRB-
cord-295807-68sukdb1	408	16	and	and	CC
cord-295807-68sukdb1	408	17	inactivating	inactivate	VBG
cord-295807-68sukdb1	408	18	genetic	genetic	JJ
cord-295807-68sukdb1	408	19	defects	defect	NNS
cord-295807-68sukdb1	408	20	in	in	IN
cord-295807-68sukdb1	408	21	NHE3	NHE3	NNP
cord-295807-68sukdb1	408	22	and	and	CC
cord-295807-68sukdb1	408	23	SLC26A3	SLC26A3	NNP
cord-295807-68sukdb1	408	24	are	be	VBP
cord-295807-68sukdb1	408	25	all	all	DT
cord-295807-68sukdb1	408	26	associated	associate	VBN
cord-295807-68sukdb1	408	27	with	with	IN
cord-295807-68sukdb1	408	28	hypersecretion	hypersecretion	NN
cord-295807-68sukdb1	408	29	and	and	CC
cord-295807-68sukdb1	408	30	diarrhea	diarrhea	NN
cord-295807-68sukdb1	408	31	[	[	-LRB-
cord-295807-68sukdb1	408	32	240	240	CD
cord-295807-68sukdb1	408	33	]	]	-RRB-
cord-295807-68sukdb1	408	34	[	[	-LRB-
cord-295807-68sukdb1	408	35	241	241	CD
cord-295807-68sukdb1	408	36	]	]	-RRB-
cord-295807-68sukdb1	408	37	[	[	-LRB-
cord-295807-68sukdb1	408	38	242	242	CD
cord-295807-68sukdb1	408	39	]	]	-RRB-
cord-295807-68sukdb1	408	40	[	[	-LRB-
cord-295807-68sukdb1	408	41	243	243	CD
cord-295807-68sukdb1	408	42	]	]	-RRB-
cord-295807-68sukdb1	408	43	.	.	.
cord-295807-68sukdb1	409	1	On	on	IN
cord-295807-68sukdb1	409	2	the	the	DT
cord-295807-68sukdb1	409	3	subject	subject	NN
cord-295807-68sukdb1	409	4	of	of	IN
cord-295807-68sukdb1	409	5	gut	gut	NN
cord-295807-68sukdb1	409	6	microbiota	microbiota	NN
cord-295807-68sukdb1	409	7	,	,	,
cord-295807-68sukdb1	409	8	intestinal	intestinal	JJ
cord-295807-68sukdb1	409	9	pH	ph	NN
cord-295807-68sukdb1	409	10	can	can	MD
cord-295807-68sukdb1	409	11	both	both	DT
cord-295807-68sukdb1	409	12	influence	influence	VB
cord-295807-68sukdb1	409	13	and	and	CC
cord-295807-68sukdb1	409	14	be	be	VB
cord-295807-68sukdb1	409	15	influenced	influence	VBN
cord-295807-68sukdb1	409	16	by	by	IN
cord-295807-68sukdb1	409	17	the	the	DT
cord-295807-68sukdb1	409	18	composition	composition	NN
cord-295807-68sukdb1	409	19	of	of	IN
cord-295807-68sukdb1	409	20	gut	gut	NN
cord-295807-68sukdb1	409	21	microbiome	microbiome	NN
cord-295807-68sukdb1	409	22	[	[	-LRB-
cord-295807-68sukdb1	409	23	244	244	CD
cord-295807-68sukdb1	409	24	]	]	-RRB-
cord-295807-68sukdb1	409	25	.	.	.
cord-295807-68sukdb1	410	1	In	in	IN
cord-295807-68sukdb1	410	2	individuals	individual	NNS
cord-295807-68sukdb1	410	3	with	with	IN
cord-295807-68sukdb1	410	4	insufficient	insufficient	JJ
cord-295807-68sukdb1	410	5	intestine	intestine	NN
cord-295807-68sukdb1	410	6	to	to	TO
cord-295807-68sukdb1	410	7	absorb	absorb	VB
cord-295807-68sukdb1	410	8	nutrients	nutrient	NNS
cord-295807-68sukdb1	410	9	(	(	-LRB-
cord-295807-68sukdb1	410	10	short	short	JJ
cord-295807-68sukdb1	410	11	bowel	bowel	NN
cord-295807-68sukdb1	410	12	syndrome	syndrome	NN
cord-295807-68sukdb1	410	13	)	)	-RRB-
cord-295807-68sukdb1	410	14	,	,	,
cord-295807-68sukdb1	410	15	unabsorbed	unabsorbed	JJ
cord-295807-68sukdb1	410	16	carbohydrates	carbohydrate	NNS
cord-295807-68sukdb1	410	17	promote	promote	VBP
cord-295807-68sukdb1	410	18	the	the	DT
cord-295807-68sukdb1	410	19	growth	growth	NN
cord-295807-68sukdb1	410	20	of	of	IN
cord-295807-68sukdb1	410	21	lactic	lactic	JJ
cord-295807-68sukdb1	410	22	acid	acid	NN
cord-295807-68sukdb1	410	23	-	-	HYPH
cord-295807-68sukdb1	410	24	producing	produce	VBG
cord-295807-68sukdb1	410	25	bacteria	bacteria	NNS
cord-295807-68sukdb1	410	26	,	,	,
cord-295807-68sukdb1	410	27	which	which	WDT
cord-295807-68sukdb1	410	28	can	can	MD
cord-295807-68sukdb1	410	29	lead	lead	VB
cord-295807-68sukdb1	410	30	to	to	IN
cord-295807-68sukdb1	410	31	D	d	NN
cord-295807-68sukdb1	410	32	-	-	HYPH
cord-295807-68sukdb1	410	33	lactic	lactic	JJ
cord-295807-68sukdb1	410	34	acidosis	acidosis	NN
cord-295807-68sukdb1	410	35	[	[	-LRB-
cord-295807-68sukdb1	410	36	245	245	CD
cord-295807-68sukdb1	410	37	]	]	-RRB-
cord-295807-68sukdb1	410	38	.	.	.
cord-295807-68sukdb1	411	1	Finally	finally	RB
cord-295807-68sukdb1	411	2	,	,	,
cord-295807-68sukdb1	411	3	the	the	DT
cord-295807-68sukdb1	411	4	absorption	absorption	NN
cord-295807-68sukdb1	411	5	of	of	IN
cord-295807-68sukdb1	411	6	many	many	JJ
cord-295807-68sukdb1	411	7	nutrients	nutrient	NNS
cord-295807-68sukdb1	411	8	depends	depend	VBZ
cord-295807-68sukdb1	411	9	on	on	IN
cord-295807-68sukdb1	411	10	the	the	DT
cord-295807-68sukdb1	411	11	action	action	NN
cord-295807-68sukdb1	411	12	of	of	IN
cord-295807-68sukdb1	411	13	H	H	NNP
cord-295807-68sukdb1	411	14	+	+	SYM
cord-295807-68sukdb1	411	15	-coupled	-coupled	JJ
cord-295807-68sukdb1	411	16	ABTs	abt	NNS
cord-295807-68sukdb1	411	17	(	(	-LRB-
cord-295807-68sukdb1	411	18	e.g.	e.g.	RB
cord-295807-68sukdb1	411	19	the	the	DT
cord-295807-68sukdb1	411	20	H	H	NNP
cord-295807-68sukdb1	411	21	+	+	SYM
cord-295807-68sukdb1	411	22	-coupled	-coupled	CD
cord-295807-68sukdb1	411	23	oligopeptide	oligopeptide	JJ
cord-295807-68sukdb1	411	24	transporters	transporter	NNS
cord-295807-68sukdb1	411	25	of	of	IN
cord-295807-68sukdb1	411	26	the	the	DT
cord-295807-68sukdb1	411	27	SLC15	SLC15	NNP
cord-295807-68sukdb1	411	28	family	family	NN
cord-295807-68sukdb1	411	29	:	:	:
cord-295807-68sukdb1	411	30	[	[	-LRB-
cord-295807-68sukdb1	411	31	246	246	CD
cord-295807-68sukdb1	411	32	]	]	-RRB-
cord-295807-68sukdb1	411	33	)	)	-RRB-
cord-295807-68sukdb1	411	34	,	,	,
cord-295807-68sukdb1	411	35	which	which	WDT
cord-295807-68sukdb1	411	36	in	in	IN
cord-295807-68sukdb1	411	37	turn	turn	NN
cord-295807-68sukdb1	411	38	require	require	VBP
cord-295807-68sukdb1	411	39	the	the	DT
cord-295807-68sukdb1	411	40	presence	presence	NN
cord-295807-68sukdb1	411	41	of	of	IN
cord-295807-68sukdb1	411	42	acid	acid	NN
cord-295807-68sukdb1	411	43	extruders	extruder	NNS
cord-295807-68sukdb1	411	44	such	such	JJ
cord-295807-68sukdb1	411	45	as	as	IN
cord-295807-68sukdb1	411	46	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	411	47	to	to	TO
cord-295807-68sukdb1	411	48	maintain	maintain	VB
cord-295807-68sukdb1	411	49	epithelial	epithelial	JJ
cord-295807-68sukdb1	411	50	pH	ph	NN
cord-295807-68sukdb1	411	51	during	during	IN
cord-295807-68sukdb1	411	52	nutrient	nutrient	NN
cord-295807-68sukdb1	411	53	absorption	absorption	NN
cord-295807-68sukdb1	411	54	.	.	.
cord-295807-68sukdb1	412	1	Indeed	indeed	RB
cord-295807-68sukdb1	412	2	,	,	,
cord-295807-68sukdb1	412	3	NBCe1-null	NBCe1-null	VBG
cord-295807-68sukdb1	412	4	mice	mouse	NNS
cord-295807-68sukdb1	412	5	exhibit	exhibit	VBP
cord-295807-68sukdb1	412	6	defective	defective	JJ
cord-295807-68sukdb1	412	7	nutrient	nutrient	NN
cord-295807-68sukdb1	412	8	absorption	absorption	NN
cord-295807-68sukdb1	412	9	,	,	,
cord-295807-68sukdb1	412	10	which	which	WDT
cord-295807-68sukdb1	412	11	contributes	contribute	VBZ
cord-295807-68sukdb1	412	12	to	to	IN
cord-295807-68sukdb1	412	13	their	-PRON-	PRP$
cord-295807-68sukdb1	412	14	general	general	JJ
cord-295807-68sukdb1	412	15	failure	failure	NN
cord-295807-68sukdb1	412	16	to	to	TO
cord-295807-68sukdb1	412	17	thrive	thrive	VB
cord-295807-68sukdb1	412	18	[	[	-LRB-
cord-295807-68sukdb1	412	19	247	247	CD
cord-295807-68sukdb1	412	20	]	]	-RRB-
cord-295807-68sukdb1	412	21	.	.	.
cord-295807-68sukdb1	413	1	The	the	DT
cord-295807-68sukdb1	413	2	ability	ability	NN
cord-295807-68sukdb1	413	3	of	of	IN
cord-295807-68sukdb1	413	4	small	small	JJ
cord-295807-68sukdb1	413	5	molecule	molecule	NN
cord-295807-68sukdb1	413	6	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	413	7	of	of	IN
cord-295807-68sukdb1	413	8	NHE3	NHE3	NNP
cord-295807-68sukdb1	413	9	(	(	-LRB-
cord-295807-68sukdb1	413	10	tenapanor	tenapanor	NNP
cord-295807-68sukdb1	413	11	)	)	-RRB-
cord-295807-68sukdb1	413	12	and	and	CC
cord-295807-68sukdb1	413	13	SLC26A3	slc26a3	NN
cord-295807-68sukdb1	413	14	(	(	-LRB-
cord-295807-68sukdb1	413	15	the	the	DT
cord-295807-68sukdb1	413	16	4,8dimethylcoumarin	4,8dimethylcoumarin	CD
cord-295807-68sukdb1	413	17	drug	drug	NN
cord-295807-68sukdb1	413	18	"	"	``
cord-295807-68sukdb1	413	19	DRAinh	DRAinh	VBN
cord-295807-68sukdb1	413	20	-	-	HYPH
cord-295807-68sukdb1	413	21	A250	a250	JJ
cord-295807-68sukdb1	413	22	"	"	''
cord-295807-68sukdb1	413	23	)	)	-RRB-
cord-295807-68sukdb1	413	24	to	to	TO
cord-295807-68sukdb1	413	25	reduce	reduce	VB
cord-295807-68sukdb1	413	26	intestinal	intestinal	JJ
cord-295807-68sukdb1	413	27	fluid	fluid	JJ
cord-295807-68sukdb1	413	28	absorption	absorption	NN
cord-295807-68sukdb1	413	29	makes	make	VBZ
cord-295807-68sukdb1	413	30	them	-PRON-	PRP
cord-295807-68sukdb1	413	31	valuable	valuable	JJ
cord-295807-68sukdb1	413	32	therapies	therapy	NNS
cord-295807-68sukdb1	413	33	for	for	IN
cord-295807-68sukdb1	413	34	irritable	irritable	JJ
cord-295807-68sukdb1	413	35	bowel	bowel	NN
cord-295807-68sukdb1	413	36	syndrome	syndrome	NN
cord-295807-68sukdb1	413	37	with	with	IN
cord-295807-68sukdb1	413	38	constipation	constipation	NN
cord-295807-68sukdb1	413	39	and	and	CC
cord-295807-68sukdb1	413	40	for	for	IN
cord-295807-68sukdb1	413	41	relief	relief	NN
cord-295807-68sukdb1	413	42	of	of	IN
cord-295807-68sukdb1	413	43	constipation	constipation	NN
cord-295807-68sukdb1	413	44	in	in	IN
cord-295807-68sukdb1	413	45	CF	CF	NNP
cord-295807-68sukdb1	413	46	[	[	-LRB-
cord-295807-68sukdb1	413	47	248	248	CD
cord-295807-68sukdb1	413	48	,	,	,
cord-295807-68sukdb1	413	49	249	249	CD
cord-295807-68sukdb1	413	50	]	]	-RRB-
cord-295807-68sukdb1	413	51	.	.	.
cord-295807-68sukdb1	414	1	The	the	DT
cord-295807-68sukdb1	414	2	CFTR	CFTR	NNP
cord-295807-68sukdb1	414	3	corrector	corrector	NN
cord-295807-68sukdb1	414	4	ivacaftor	ivacaftor	NN
cord-295807-68sukdb1	414	5	improves	improve	VBZ
cord-295807-68sukdb1	414	6	intestinal	intestinal	JJ
cord-295807-68sukdb1	414	7	HCO3secretion	hco3secretion	NN
cord-295807-68sukdb1	414	8	and	and	CC
cord-295807-68sukdb1	414	9	nutrient	nutrient	NN
cord-295807-68sukdb1	414	10	absorption	absorption	NN
cord-295807-68sukdb1	414	11	in	in	IN
cord-295807-68sukdb1	414	12	individuals	individual	NNS
cord-295807-68sukdb1	414	13	with	with	IN
cord-295807-68sukdb1	414	14	CF	CF	NNP
cord-295807-68sukdb1	414	15	[	[	-LRB-
cord-295807-68sukdb1	414	16	250	250	CD
cord-295807-68sukdb1	414	17	]	]	-RRB-
cord-295807-68sukdb1	414	18	.	.	.
cord-295807-68sukdb1	415	1	The	the	DT
cord-295807-68sukdb1	415	2	mode	mode	NN
cord-295807-68sukdb1	415	3	of	of	IN
cord-295807-68sukdb1	415	4	action	action	NN
cord-295807-68sukdb1	415	5	of	of	IN
cord-295807-68sukdb1	415	6	the	the	DT
cord-295807-68sukdb1	415	7	anti	anti	JJ
cord-295807-68sukdb1	415	8	-	-	JJ
cord-295807-68sukdb1	415	9	constipation	constipation	JJ
cord-295807-68sukdb1	415	10	drug	drug	NN
cord-295807-68sukdb1	415	11	linaclotide	linaclotide	NN
cord-295807-68sukdb1	415	12	(	(	-LRB-
cord-295807-68sukdb1	415	13	LINZESS	LINZESS	NNP
cord-295807-68sukdb1	416	1	®	®	VB
cord-295807-68sukdb1	416	2	:	:	:
cord-295807-68sukdb1	416	3	a	a	DT
cord-295807-68sukdb1	416	4	guanylate	guanylate	NN
cord-295807-68sukdb1	416	5	cyclase	cyclase	NN
cord-295807-68sukdb1	416	6	C	C	NNP
cord-295807-68sukdb1	416	7	receptor	receptor	NN
cord-295807-68sukdb1	416	8	agonist	agonist	NN
cord-295807-68sukdb1	416	9	)	)	-RRB-
cord-295807-68sukdb1	416	10	encompasses	encompass	VBZ
cord-295807-68sukdb1	416	11	both	both	DT
cord-295807-68sukdb1	416	12	paradigms	paradigm	NNS
cord-295807-68sukdb1	416	13	by	by	IN
cord-295807-68sukdb1	416	14	the	the	DT
cord-295807-68sukdb1	416	15	cGMPmediated	cgmpmediate	VBN
cord-295807-68sukdb1	416	16	reduction	reduction	NN
cord-295807-68sukdb1	416	17	of	of	IN
cord-295807-68sukdb1	416	18	NHE3	NHE3	NNP
cord-295807-68sukdb1	416	19	[	[	-LRB-
cord-295807-68sukdb1	416	20	251	251	CD
cord-295807-68sukdb1	416	21	]	]	-RRB-
cord-295807-68sukdb1	416	22	and	and	CC
cord-295807-68sukdb1	416	23	activation	activation	NN
cord-295807-68sukdb1	416	24	of	of	IN
cord-295807-68sukdb1	416	25	CFTR	CFTR	NNP
cord-295807-68sukdb1	416	26	activities	activity	NNS
cord-295807-68sukdb1	416	27	[	[	-LRB-
cord-295807-68sukdb1	416	28	252	252	CD
cord-295807-68sukdb1	416	29	]	]	-RRB-
cord-295807-68sukdb1	416	30	.	.	.
cord-295807-68sukdb1	417	1	Nephron	Nephron	NNP
cord-295807-68sukdb1	417	2	function	function	NN
cord-295807-68sukdb1	417	3	.	.	.
cord-295807-68sukdb1	418	1	The	the	DT
cord-295807-68sukdb1	418	2	kidneys	kidney	NNS
cord-295807-68sukdb1	418	3	are	be	VBP
cord-295807-68sukdb1	418	4	vital	vital	JJ
cord-295807-68sukdb1	418	5	to	to	IN
cord-295807-68sukdb1	418	6	whole	whole	JJ
cord-295807-68sukdb1	418	7	body	body	NN
cord-295807-68sukdb1	418	8	pH	ph	NN
cord-295807-68sukdb1	418	9	balance	balance	NN
cord-295807-68sukdb1	418	10	(	(	-LRB-
cord-295807-68sukdb1	418	11	see	see	VB
cord-295807-68sukdb1	418	12	Acid	Acid	NNP
cord-295807-68sukdb1	418	13	-	-	HYPH
cord-295807-68sukdb1	418	14	Base	Base	NNP
cord-295807-68sukdb1	418	15	Homeostasis	Homeostasis	NNP
cord-295807-68sukdb1	418	16	)	)	-RRB-
cord-295807-68sukdb1	418	17	.	.	.
cord-295807-68sukdb1	419	1	It	-PRON-	PRP
cord-295807-68sukdb1	419	2	is	be	VBZ
cord-295807-68sukdb1	419	3	the	the	DT
cord-295807-68sukdb1	419	4	kidneys	kidney	NNS
cord-295807-68sukdb1	419	5	that	that	WDT
cord-295807-68sukdb1	419	6	generate	generate	VBP
cord-295807-68sukdb1	419	7	HCO3	HCO3	NNP
cord-295807-68sukdb1	419	8	-	-	HYPH
cord-295807-68sukdb1	419	9	,	,	,
cord-295807-68sukdb1	419	10	reabsorb	reabsorb	VB
cord-295807-68sukdb1	419	11	HCO3from	HCO3from	NNP
cord-295807-68sukdb1	419	12	the	the	DT
cord-295807-68sukdb1	419	13	glomerular	glomerular	JJ
cord-295807-68sukdb1	419	14	filtrate	filtrate	NN
cord-295807-68sukdb1	419	15	to	to	TO
cord-295807-68sukdb1	419	16	prevent	prevent	VB
cord-295807-68sukdb1	419	17	its	-PRON-	PRP$
cord-295807-68sukdb1	419	18	loss	loss	NN
cord-295807-68sukdb1	419	19	in	in	IN
cord-295807-68sukdb1	419	20	urine	urine	NN
cord-295807-68sukdb1	419	21	,	,	,
cord-295807-68sukdb1	419	22	and	and	CC
cord-295807-68sukdb1	419	23	excrete	excrete	VB
cord-295807-68sukdb1	419	24	H	h	NN
cord-295807-68sukdb1	419	25	+	+	CC
cord-295807-68sukdb1	419	26	in	in	IN
cord-295807-68sukdb1	419	27	the	the	DT
cord-295807-68sukdb1	419	28	form	form	NN
cord-295807-68sukdb1	419	29	of	of	IN
cord-295807-68sukdb1	419	30	NH4	NH4	NNP
cord-295807-68sukdb1	419	31	+	+	SYM
cord-295807-68sukdb1	419	32	or	or	CC
cord-295807-68sukdb1	419	33	titratable	titratable	JJ
cord-295807-68sukdb1	419	34	acids	acid	NNS
cord-295807-68sukdb1	419	35	such	such	JJ
cord-295807-68sukdb1	419	36	as	as	IN
cord-295807-68sukdb1	419	37	phosphate	phosphate	NN
cord-295807-68sukdb1	419	38	[	[	-LRB-
cord-295807-68sukdb1	419	39	253	253	CD
cord-295807-68sukdb1	419	40	]	]	-RRB-
cord-295807-68sukdb1	420	1	(	(	-LRB-
cord-295807-68sukdb1	420	2	Figure	figure	NN
cord-295807-68sukdb1	420	3	2	2	CD
cord-295807-68sukdb1	420	4	)	)	-RRB-
cord-295807-68sukdb1	420	5	.	.	.
cord-295807-68sukdb1	421	1	Thus	thus	RB
cord-295807-68sukdb1	421	2	,	,	,
cord-295807-68sukdb1	421	3	it	-PRON-	PRP
cord-295807-68sukdb1	421	4	is	be	VBZ
cord-295807-68sukdb1	421	5	no	no	DT
cord-295807-68sukdb1	421	6	surprise	surprise	NN
cord-295807-68sukdb1	421	7	that	that	IN
cord-295807-68sukdb1	421	8	defects	defect	NNS
cord-295807-68sukdb1	421	9	in	in	IN
cord-295807-68sukdb1	421	10	renal	renal	JJ
cord-295807-68sukdb1	421	11	transport	transport	NN
cord-295807-68sukdb1	421	12	mechanisms	mechanism	NNS
cord-295807-68sukdb1	421	13	result	result	VBP
cord-295807-68sukdb1	421	14	in	in	IN
cord-295807-68sukdb1	421	15	MAc	MAc	NNP
cord-295807-68sukdb1	421	16	.	.	.
cord-295807-68sukdb1	422	1	These	these	DT
cord-295807-68sukdb1	422	2	acidifying	acidify	VBG
cord-295807-68sukdb1	422	3	diseases	disease	NNS
cord-295807-68sukdb1	422	4	can	can	MD
cord-295807-68sukdb1	422	5	be	be	VB
cord-295807-68sukdb1	422	6	acquired	acquire	VBN
cord-295807-68sukdb1	422	7	or	or	CC
cord-295807-68sukdb1	422	8	genetic	genetic	JJ
cord-295807-68sukdb1	422	9	.	.	.
cord-295807-68sukdb1	423	1	Fanconi	Fanconi	NNP
cord-295807-68sukdb1	423	2	syndrome	syndrome	NN
cord-295807-68sukdb1	423	3	is	be	VBZ
cord-295807-68sukdb1	423	4	a	a	DT
cord-295807-68sukdb1	423	5	degeneration	degeneration	NN
cord-295807-68sukdb1	423	6	of	of	IN
cord-295807-68sukdb1	423	7	the	the	DT
cord-295807-68sukdb1	423	8	proximal	proximal	JJ
cord-295807-68sukdb1	423	9	tubule	tubule	NN
cord-295807-68sukdb1	423	10	,	,	,
cord-295807-68sukdb1	423	11	while	while	IN
cord-295807-68sukdb1	423	12	renal	renal	JJ
cord-295807-68sukdb1	423	13	tubular	tubular	JJ
cord-295807-68sukdb1	423	14	acidosis	acidosis	NN
cord-295807-68sukdb1	423	15	(	(	-LRB-
cord-295807-68sukdb1	423	16	RTA	RTA	NNP
cord-295807-68sukdb1	423	17	[	[	-LRB-
cord-295807-68sukdb1	423	18	254	254	CD
cord-295807-68sukdb1	423	19	]	]	-RRB-
cord-295807-68sukdb1	423	20	)	)	-RRB-
cord-295807-68sukdb1	423	21	can	can	MD
cord-295807-68sukdb1	423	22	result	result	VB
cord-295807-68sukdb1	423	23	from	from	IN
cord-295807-68sukdb1	423	24	mutations	mutation	NNS
cord-295807-68sukdb1	423	25	in	in	IN
cord-295807-68sukdb1	423	26	acid	acid	NN
cord-295807-68sukdb1	423	27	-	-	HYPH
cord-295807-68sukdb1	423	28	base	base	NN
cord-295807-68sukdb1	423	29	transporters	transporter	NNS
cord-295807-68sukdb1	423	30	such	such	JJ
cord-295807-68sukdb1	423	31	as	as	IN
cord-295807-68sukdb1	423	32	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	423	33	(	(	-LRB-
cord-295807-68sukdb1	423	34	type	type	NN
cord-295807-68sukdb1	423	35	II	II	NNP
cord-295807-68sukdb1	423	36	proximal	proximal	JJ
cord-295807-68sukdb1	423	37	RTA	RTA	NNP
cord-295807-68sukdb1	423	38	:	:	:
cord-295807-68sukdb1	423	39	pRTA	prta	NN
cord-295807-68sukdb1	423	40	)	)	-RRB-
cord-295807-68sukdb1	423	41	,	,	,
cord-295807-68sukdb1	423	42	H	h	NN
cord-295807-68sukdb1	423	43	+	+	CC
cord-295807-68sukdb1	424	1	-ATPase	-ATPase	NNP
cord-295807-68sukdb1	424	2	or	or	CC
cord-295807-68sukdb1	424	3	AE1	AE1	NNP
cord-295807-68sukdb1	424	4	(	(	-LRB-
cord-295807-68sukdb1	424	5	type	type	NN
cord-295807-68sukdb1	424	6	I	-PRON-	PRP
cord-295807-68sukdb1	424	7	distal	distal	JJ
cord-295807-68sukdb1	424	8	RTA	RTA	NNP
cord-295807-68sukdb1	424	9	:	:	:
cord-295807-68sukdb1	424	10	dRTA	dRTA	NNP
cord-295807-68sukdb1	424	11	)	)	-RRB-
cord-295807-68sukdb1	424	12	,	,	,
cord-295807-68sukdb1	424	13	CAII	CAII	NNP
cord-295807-68sukdb1	424	14	(	(	-LRB-
cord-295807-68sukdb1	424	15	type	type	NN
cord-295807-68sukdb1	424	16	III	III	NNP
cord-295807-68sukdb1	424	17	RTA	RTA	NNP
cord-295807-68sukdb1	424	18	)	)	-RRB-
cord-295807-68sukdb1	424	19	,	,	,
cord-295807-68sukdb1	424	20	or	or	CC
cord-295807-68sukdb1	424	21	disruption	disruption	NN
cord-295807-68sukdb1	424	22	of	of	IN
cord-295807-68sukdb1	424	23	H	h	NN
cord-295807-68sukdb1	424	24	+	+	CC
cord-295807-68sukdb1	424	25	secretion	secretion	NN
cord-295807-68sukdb1	424	26	due	due	IN
cord-295807-68sukdb1	424	27	to	to	IN
cord-295807-68sukdb1	424	28	hypoaldosteronism	hypoaldosteronism	NNP
cord-295807-68sukdb1	424	29	(	(	-LRB-
cord-295807-68sukdb1	424	30	type	type	NN
cord-295807-68sukdb1	424	31	IV	IV	NNP
cord-295807-68sukdb1	424	32	dRTA	dRTA	NNP
cord-295807-68sukdb1	424	33	)	)	-RRB-
cord-295807-68sukdb1	424	34	.	.	.
cord-295807-68sukdb1	425	1	Chronic	chronic	JJ
cord-295807-68sukdb1	425	2	kidney	kidney	NN
cord-295807-68sukdb1	425	3	disease	disease	NN
cord-295807-68sukdb1	425	4	(	(	-LRB-
cord-295807-68sukdb1	425	5	CKD	CKD	NNP
cord-295807-68sukdb1	425	6	)	)	-RRB-
cord-295807-68sukdb1	425	7	is	be	VBZ
cord-295807-68sukdb1	425	8	also	also	RB
cord-295807-68sukdb1	425	9	associated	associate	VBN
cord-295807-68sukdb1	425	10	with	with	IN
cord-295807-68sukdb1	425	11	MAc	MAc	NNP
cord-295807-68sukdb1	425	12	[	[	-LRB-
cord-295807-68sukdb1	425	13	255	255	CD
cord-295807-68sukdb1	425	14	]	]	-RRB-
cord-295807-68sukdb1	425	15	,	,	,
cord-295807-68sukdb1	425	16	and	and	CC
cord-295807-68sukdb1	425	17	MAc	MAc	NNP
cord-295807-68sukdb1	425	18	itself	-PRON-	PRP
cord-295807-68sukdb1	425	19	promotes	promote	VBZ
cord-295807-68sukdb1	425	20	progression	progression	NN
cord-295807-68sukdb1	425	21	of	of	IN
cord-295807-68sukdb1	425	22	CKD	CKD	NNP
cord-295807-68sukdb1	425	23	(	(	-LRB-
cord-295807-68sukdb1	425	24	see	see	VB
cord-295807-68sukdb1	425	25	below	below	RB
cord-295807-68sukdb1	425	26	)	)	-RRB-
cord-295807-68sukdb1	425	27	.	.	.
cord-295807-68sukdb1	426	1	MAlk	MAlk	NNP
cord-295807-68sukdb1	426	2	is	be	VBZ
cord-295807-68sukdb1	426	3	a	a	DT
cord-295807-68sukdb1	426	4	common	common	JJ
cord-295807-68sukdb1	426	5	finding	finding	NN
cord-295807-68sukdb1	426	6	in	in	IN
cord-295807-68sukdb1	426	7	CF	cf	NN
cord-295807-68sukdb1	426	8	patients	patient	NNS
cord-295807-68sukdb1	426	9	.	.	.
cord-295807-68sukdb1	427	1	CF	cf	NN
cord-295807-68sukdb1	427	2	-	-	HYPH
cord-295807-68sukdb1	427	3	model	model	NN
cord-295807-68sukdb1	427	4	mice	mouse	NNS
cord-295807-68sukdb1	427	5	are	be	VBP
cord-295807-68sukdb1	427	6	less	less	RBR
cord-295807-68sukdb1	427	7	capable	capable	JJ
cord-295807-68sukdb1	427	8	of	of	IN
cord-295807-68sukdb1	427	9	defending	defend	VBG
cord-295807-68sukdb1	427	10	against	against	IN
cord-295807-68sukdb1	427	11	HCO3loads	hco3load	NNS
cord-295807-68sukdb1	427	12	than	than	IN
cord-295807-68sukdb1	427	13	their	-PRON-	PRP$
cord-295807-68sukdb1	427	14	wild	wild	JJ
cord-295807-68sukdb1	427	15	-	-	HYPH
cord-295807-68sukdb1	427	16	type	type	NN
cord-295807-68sukdb1	427	17	counterparts	counterpart	NNS
cord-295807-68sukdb1	427	18	,	,	,
cord-295807-68sukdb1	427	19	due	due	IN
cord-295807-68sukdb1	427	20	to	to	IN
cord-295807-68sukdb1	427	21	downregulation	downregulation	NN
cord-295807-68sukdb1	427	22	of	of	IN
cord-295807-68sukdb1	427	23	the	the	DT
cord-295807-68sukdb1	427	24	renal	renal	JJ
cord-295807-68sukdb1	427	25	HCO3	HCO3	NNP
cord-295807-68sukdb1	427	26	-secreting	-secreting	NNP
cord-295807-68sukdb1	427	27	anion	anion	NN
cord-295807-68sukdb1	427	28	exchanger	exchanger	NN
cord-295807-68sukdb1	427	29	pendrin	pendrin	NNP
cord-295807-68sukdb1	427	30	[	[	-LRB-
cord-295807-68sukdb1	427	31	256	256	CD
cord-295807-68sukdb1	427	32	]	]	-RRB-
cord-295807-68sukdb1	427	33	and	and	CC
cord-295807-68sukdb1	427	34	presumably	presumably	RB
cord-295807-68sukdb1	427	35	loss	loss	NN
cord-295807-68sukdb1	427	36	of	of	IN
cord-295807-68sukdb1	427	37	direct	direct	JJ
cord-295807-68sukdb1	427	38	CFTR	CFTR	NNP
cord-295807-68sukdb1	427	39	-	-	HYPH
cord-295807-68sukdb1	427	40	mediated	mediate	VBN
cord-295807-68sukdb1	427	41	HCO3secretion	HCO3secretion	NNP
cord-295807-68sukdb1	427	42	.	.	.
cord-295807-68sukdb1	428	1	Concurrently	concurrently	RB
cord-295807-68sukdb1	428	2	,	,	,
cord-295807-68sukdb1	428	3	acid	acid	NN
cord-295807-68sukdb1	428	4	-	-	HYPH
cord-295807-68sukdb1	428	5	base	base	NN
cord-295807-68sukdb1	428	6	status	status	NN
cord-295807-68sukdb1	428	7	has	have	VBZ
cord-295807-68sukdb1	428	8	profound	profound	JJ
cord-295807-68sukdb1	428	9	influence	influence	NN
cord-295807-68sukdb1	428	10	on	on	IN
cord-295807-68sukdb1	428	11	kidney	kidney	NN
cord-295807-68sukdb1	428	12	function	function	NN
cord-295807-68sukdb1	428	13	.	.	.
cord-295807-68sukdb1	429	1	The	the	DT
cord-295807-68sukdb1	429	2	very	very	RB
cord-295807-68sukdb1	429	3	mechanisms	mechanism	NNS
cord-295807-68sukdb1	429	4	that	that	WDT
cord-295807-68sukdb1	429	5	allow	allow	VBP
cord-295807-68sukdb1	429	6	the	the	DT
cord-295807-68sukdb1	429	7	kidneys	kidney	NNS
cord-295807-68sukdb1	429	8	to	to	TO
cord-295807-68sukdb1	429	9	increase	increase	VB
cord-295807-68sukdb1	429	10	acid	acid	JJ
cord-295807-68sukdb1	429	11	excretion	excretion	NN
cord-295807-68sukdb1	429	12	in	in	IN
cord-295807-68sukdb1	429	13	response	response	NN
cord-295807-68sukdb1	429	14	to	to	IN
cord-295807-68sukdb1	429	15	acute	acute	JJ
cord-295807-68sukdb1	429	16	increases	increase	NNS
cord-295807-68sukdb1	429	17	in	in	IN
cord-295807-68sukdb1	429	18	acid	acid	NN
cord-295807-68sukdb1	429	19	load	load	NN
cord-295807-68sukdb1	429	20	(	(	-LRB-
cord-295807-68sukdb1	429	21	e.g.	e.g.	RB
cord-295807-68sukdb1	429	22	,	,	,
cord-295807-68sukdb1	429	23	ammoniagenesis	ammoniagenesis	NNP
cord-295807-68sukdb1	429	24	and	and	CC
cord-295807-68sukdb1	429	25	the	the	DT
cord-295807-68sukdb1	429	26	renal	renal	JJ
cord-295807-68sukdb1	429	27	endocrine	endocrine	JJ
cord-295807-68sukdb1	429	28	response	response	NN
cord-295807-68sukdb1	429	29	to	to	IN
cord-295807-68sukdb1	429	30	acidosis	acidosis	NN
cord-295807-68sukdb1	429	31	)	)	-RRB-
cord-295807-68sukdb1	429	32	can	can	MD
cord-295807-68sukdb1	429	33	be	be	VB
cord-295807-68sukdb1	429	34	maladaptive	maladaptive	JJ
cord-295807-68sukdb1	429	35	in	in	IN
cord-295807-68sukdb1	429	36	chronic	chronic	JJ
cord-295807-68sukdb1	429	37	MAc	MAc	NNP
cord-295807-68sukdb1	429	38	,	,	,
cord-295807-68sukdb1	429	39	leading	lead	VBG
cord-295807-68sukdb1	429	40	to	to	IN
cord-295807-68sukdb1	429	41	inflammation	inflammation	NN
cord-295807-68sukdb1	429	42	and	and	CC
cord-295807-68sukdb1	429	43	fibrosis	fibrosis	NN
cord-295807-68sukdb1	429	44	[	[	-LRB-
cord-295807-68sukdb1	429	45	257	257	CD
cord-295807-68sukdb1	429	46	]	]	-RRB-
cord-295807-68sukdb1	429	47	.	.	.
cord-295807-68sukdb1	430	1	It	-PRON-	PRP
cord-295807-68sukdb1	430	2	is	be	VBZ
cord-295807-68sukdb1	430	3	perhaps	perhaps	RB
cord-295807-68sukdb1	430	4	then	then	RB
cord-295807-68sukdb1	430	5	not	not	RB
cord-295807-68sukdb1	430	6	coincidental	coincidental	JJ
cord-295807-68sukdb1	430	7	that	that	IN
cord-295807-68sukdb1	430	8	low	low	JJ
cord-295807-68sukdb1	430	9	serum	serum	NN
cord-295807-68sukdb1	430	10	[	[	-LRB-
cord-295807-68sukdb1	430	11	HCO3	HCO3	NNP
cord-295807-68sukdb1	430	12	-	-	,
cord-295807-68sukdb1	430	13	]	]	-RRB-
cord-295807-68sukdb1	430	14	is	be	VBZ
cord-295807-68sukdb1	430	15	linked	link	VBN
cord-295807-68sukdb1	430	16	to	to	IN
cord-295807-68sukdb1	430	17	a	a	DT
cord-295807-68sukdb1	430	18	higher	high	JJR
cord-295807-68sukdb1	430	19	risk	risk	NN
cord-295807-68sukdb1	430	20	of	of	IN
cord-295807-68sukdb1	430	21	chronic	chronic	JJ
cord-295807-68sukdb1	430	22	kidney	kidney	NN
cord-295807-68sukdb1	430	23	disease	disease	NN
cord-295807-68sukdb1	430	24	in	in	IN
cord-295807-68sukdb1	430	25	both	both	DT
cord-295807-68sukdb1	430	26	adults	adult	NNS
cord-295807-68sukdb1	430	27	and	and	CC
cord-295807-68sukdb1	430	28	children	child	NNS
cord-295807-68sukdb1	430	29	[	[	-LRB-
cord-295807-68sukdb1	430	30	258	258	CD
cord-295807-68sukdb1	430	31	,	,	,
cord-295807-68sukdb1	430	32	259	259	CD
cord-295807-68sukdb1	430	33	]	]	-RRB-
cord-295807-68sukdb1	430	34	.	.	.
cord-295807-68sukdb1	431	1	An	an	DT
cord-295807-68sukdb1	431	2	additional	additional	JJ
cord-295807-68sukdb1	431	3	set	set	NN
cord-295807-68sukdb1	431	4	of	of	IN
cord-295807-68sukdb1	431	5	renal	renal	JJ
cord-295807-68sukdb1	431	6	pathologies	pathology	NNS
cord-295807-68sukdb1	431	7	follows	follow	VBZ
cord-295807-68sukdb1	431	8	the	the	DT
cord-295807-68sukdb1	431	9	integration	integration	NN
cord-295807-68sukdb1	431	10	of	of	IN
cord-295807-68sukdb1	431	11	acid	acid	NN
cord-295807-68sukdb1	431	12	/	/	SYM
cord-295807-68sukdb1	431	13	base	base	NN
cord-295807-68sukdb1	431	14	and	and	CC
cord-295807-68sukdb1	431	15	salt	salt	NN
cord-295807-68sukdb1	431	16	/	/	SYM
cord-295807-68sukdb1	431	17	water	water	NN
cord-295807-68sukdb1	431	18	handling	handling	NN
cord-295807-68sukdb1	431	19	by	by	IN
cord-295807-68sukdb1	431	20	the	the	DT
cord-295807-68sukdb1	431	21	nephron	nephron	NN
cord-295807-68sukdb1	431	22	.	.	.
cord-295807-68sukdb1	432	1	For	for	IN
cord-295807-68sukdb1	432	2	example	example	NN
cord-295807-68sukdb1	432	3	,	,	,
cord-295807-68sukdb1	432	4	states	state	NNS
cord-295807-68sukdb1	432	5	and	and	CC
cord-295807-68sukdb1	432	6	conditions	condition	NNS
cord-295807-68sukdb1	432	7	of	of	IN
cord-295807-68sukdb1	432	8	increased	increase	VBN
cord-295807-68sukdb1	432	9	sodium	sodium	NN
cord-295807-68sukdb1	432	10	reabsorption	reabsorption	NN
cord-295807-68sukdb1	432	11	by	by	IN
cord-295807-68sukdb1	432	12	the	the	DT
cord-295807-68sukdb1	432	13	proximal	proximal	JJ
cord-295807-68sukdb1	432	14	tubule	tubule	NN
cord-295807-68sukdb1	432	15	(	(	-LRB-
cord-295807-68sukdb1	432	16	e.g.	e.g.	RB
cord-295807-68sukdb1	432	17	,	,	,
cord-295807-68sukdb1	432	18	volume	volume	NN
cord-295807-68sukdb1	432	19	contraction	contraction	NN
cord-295807-68sukdb1	432	20	)	)	-RRB-
cord-295807-68sukdb1	432	21	or	or	CC
cord-295807-68sukdb1	432	22	collecting	collect	VBG
cord-295807-68sukdb1	432	23	duct	duct	NN
cord-295807-68sukdb1	432	24	(	(	-LRB-
cord-295807-68sukdb1	432	25	e.g.	e.g.	RB
cord-295807-68sukdb1	432	26	,	,	,
cord-295807-68sukdb1	432	27	hyperactivity	hyperactivity	NN
cord-295807-68sukdb1	432	28	of	of	IN
cord-295807-68sukdb1	432	29	the	the	DT
cord-295807-68sukdb1	432	30	epithelial	epithelial	JJ
cord-295807-68sukdb1	432	31	Na	Na	NNP
cord-295807-68sukdb1	432	32	+	+	SYM
cord-295807-68sukdb1	432	33	channel	channel	NN
cord-295807-68sukdb1	432	34	ENaC	ENaC	NNP
cord-295807-68sukdb1	432	35	in	in	IN
cord-295807-68sukdb1	432	36	Liddle	Liddle	NNP
cord-295807-68sukdb1	432	37	's	's	POS
cord-295807-68sukdb1	432	38	syndrome	syndrome	NN
cord-295807-68sukdb1	432	39	)	)	-RRB-
cord-295807-68sukdb1	432	40	result	result	VBP
cord-295807-68sukdb1	432	41	in	in	IN
cord-295807-68sukdb1	432	42	MAlk	MAlk	NNP
cord-295807-68sukdb1	432	43	(	(	-LRB-
cord-295807-68sukdb1	432	44	see	see	VB
cord-295807-68sukdb1	432	45	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	432	46	Alkalosis	Alkalosis	NNP
cord-295807-68sukdb1	432	47	)	)	-RRB-
cord-295807-68sukdb1	432	48	while	while	IN
cord-295807-68sukdb1	432	49	hyperkalemia	hyperkalemia	NN
cord-295807-68sukdb1	432	50	can	can	MD
cord-295807-68sukdb1	432	51	cause	cause	VB
cord-295807-68sukdb1	432	52	MAc	MAc	NNP
cord-295807-68sukdb1	432	53	[	[	-LRB-
cord-295807-68sukdb1	432	54	260	260	CD
cord-295807-68sukdb1	432	55	]	]	-RRB-
cord-295807-68sukdb1	432	56	.	.	.
cord-295807-68sukdb1	433	1	Stone	stone	NN
cord-295807-68sukdb1	433	2	formation	formation	NN
cord-295807-68sukdb1	433	3	.	.	.
cord-295807-68sukdb1	434	1	Urinary	urinary	JJ
cord-295807-68sukdb1	434	2	pH	pH	NNP
cord-295807-68sukdb1	434	3	can	can	MD
cord-295807-68sukdb1	434	4	influence	influence	VB
cord-295807-68sukdb1	434	5	stone	stone	NN
cord-295807-68sukdb1	434	6	formation	formation	NN
cord-295807-68sukdb1	434	7	which	which	WDT
cord-295807-68sukdb1	434	8	can	can	MD
cord-295807-68sukdb1	434	9	lead	lead	VB
cord-295807-68sukdb1	434	10	to	to	IN
cord-295807-68sukdb1	434	11	inflammation	inflammation	NN
cord-295807-68sukdb1	434	12	and	and	CC
cord-295807-68sukdb1	434	13	obstructive	obstructive	JJ
cord-295807-68sukdb1	434	14	kidney	kidney	NN
cord-295807-68sukdb1	434	15	injury	injury	NN
cord-295807-68sukdb1	434	16	.	.	.
cord-295807-68sukdb1	435	1	A	a	DT
cord-295807-68sukdb1	435	2	high	high	JJ
cord-295807-68sukdb1	435	3	urinary	urinary	JJ
cord-295807-68sukdb1	435	4	pH	ph	NN
cord-295807-68sukdb1	435	5	can	can	MD
cord-295807-68sukdb1	435	6	cause	cause	VB
cord-295807-68sukdb1	435	7	the	the	DT
cord-295807-68sukdb1	435	8	formation	formation	NN
cord-295807-68sukdb1	435	9	of	of	IN
cord-295807-68sukdb1	435	10	calcium	calcium	NN
cord-295807-68sukdb1	435	11	oxalate	oxalate	NN
cord-295807-68sukdb1	435	12	or	or	CC
cord-295807-68sukdb1	435	13	calcium	calcium	NN
cord-295807-68sukdb1	435	14	phosphate	phosphate	NN
cord-295807-68sukdb1	435	15	crystals	crystal	NNS
cord-295807-68sukdb1	435	16	,	,	,
cord-295807-68sukdb1	435	17	while	while	IN
cord-295807-68sukdb1	435	18	a	a	DT
cord-295807-68sukdb1	435	19	low	low	JJ
cord-295807-68sukdb1	435	20	urinary	urinary	JJ
cord-295807-68sukdb1	435	21	pH	ph	NN
cord-295807-68sukdb1	435	22	promotes	promote	VBZ
cord-295807-68sukdb1	435	23	uric	uric	JJ
cord-295807-68sukdb1	435	24	acid	acid	NN
cord-295807-68sukdb1	435	25	crystallization	crystallization	NN
cord-295807-68sukdb1	435	26	[	[	-LRB-
cord-295807-68sukdb1	435	27	261	261	CD
cord-295807-68sukdb1	435	28	]	]	-RRB-
cord-295807-68sukdb1	435	29	.	.	.
cord-295807-68sukdb1	436	1	Urinary	urinary	JJ
cord-295807-68sukdb1	436	2	pH	pH	NNP
cord-295807-68sukdb1	436	3	can	can	MD
cord-295807-68sukdb1	436	4	be	be	VB
cord-295807-68sukdb1	436	5	modified	modify	VBN
cord-295807-68sukdb1	436	6	by	by	IN
cord-295807-68sukdb1	436	7	uropathogenic	uropathogenic	JJ
cord-295807-68sukdb1	436	8	bacteria	bacteria	NNS
cord-295807-68sukdb1	436	9	.	.	.
cord-295807-68sukdb1	437	1	Urease	Urease	NNP
cord-295807-68sukdb1	437	2	-	-	HYPH
cord-295807-68sukdb1	437	3	expressing	express	VBG
cord-295807-68sukdb1	437	4	bacteria	bacteria	NNS
cord-295807-68sukdb1	437	5	generate	generate	VBP
cord-295807-68sukdb1	437	6	NH3	NH3	NNP
cord-295807-68sukdb1	437	7	,	,	,
cord-295807-68sukdb1	437	8	which	which	WDT
cord-295807-68sukdb1	437	9	can	can	MD
cord-295807-68sukdb1	437	10	substantially	substantially	RB
cord-295807-68sukdb1	437	11	raise	raise	VB
cord-295807-68sukdb1	437	12	urinary	urinary	JJ
cord-295807-68sukdb1	437	13	pH	ph	NN
cord-295807-68sukdb1	437	14	,	,	,
cord-295807-68sukdb1	437	15	promoting	promote	VBG
cord-295807-68sukdb1	437	16	deposition	deposition	NN
cord-295807-68sukdb1	437	17	of	of	IN
cord-295807-68sukdb1	437	18	struvite	struvite	NN
cord-295807-68sukdb1	437	19	and	and	CC
cord-295807-68sukdb1	437	20	apatite	apatite	NN
cord-295807-68sukdb1	437	21	crystals	crystal	NNS
cord-295807-68sukdb1	437	22	[	[	-LRB-
cord-295807-68sukdb1	437	23	262	262	CD
cord-295807-68sukdb1	437	24	]	]	-RRB-
cord-295807-68sukdb1	437	25	.	.	.
cord-295807-68sukdb1	438	1	Besides	besides	IN
cord-295807-68sukdb1	438	2	the	the	DT
cord-295807-68sukdb1	438	3	consequences	consequence	NNS
cord-295807-68sukdb1	438	4	of	of	IN
cord-295807-68sukdb1	438	5	stone	stone	NN
cord-295807-68sukdb1	438	6	formation	formation	NN
cord-295807-68sukdb1	438	7	in	in	IN
cord-295807-68sukdb1	438	8	the	the	DT
cord-295807-68sukdb1	438	9	urinary	urinary	JJ
cord-295807-68sukdb1	438	10	tract	tract	NN
cord-295807-68sukdb1	438	11	,	,	,
cord-295807-68sukdb1	438	12	these	these	DT
cord-295807-68sukdb1	438	13	deposits	deposit	NNS
cord-295807-68sukdb1	438	14	can	can	MD
cord-295807-68sukdb1	438	15	cause	cause	VB
cord-295807-68sukdb1	438	16	the	the	DT
cord-295807-68sukdb1	438	17	encrustation	encrustation	NN
cord-295807-68sukdb1	438	18	and	and	CC
cord-295807-68sukdb1	438	19	blockage	blockage	NN
cord-295807-68sukdb1	438	20	of	of	IN
cord-295807-68sukdb1	438	21	indwelling	indwell	VBG
cord-295807-68sukdb1	438	22	catheters	catheter	NNS
cord-295807-68sukdb1	438	23	[	[	-LRB-
cord-295807-68sukdb1	438	24	263	263	CD
cord-295807-68sukdb1	438	25	]	]	-RRB-
cord-295807-68sukdb1	438	26	.	.	.
cord-295807-68sukdb1	439	1	It	-PRON-	PRP
cord-295807-68sukdb1	439	2	is	be	VBZ
cord-295807-68sukdb1	439	3	interesting	interesting	JJ
cord-295807-68sukdb1	439	4	to	to	TO
cord-295807-68sukdb1	439	5	recall	recall	VB
cord-295807-68sukdb1	439	6	that	that	IN
cord-295807-68sukdb1	439	7	the	the	DT
cord-295807-68sukdb1	439	8	pathogenic	pathogenic	JJ
cord-295807-68sukdb1	439	9	action	action	NN
cord-295807-68sukdb1	439	10	of	of	IN
cord-295807-68sukdb1	439	11	another	another	DT
cord-295807-68sukdb1	439	12	bacterium	bacterium	NN
cord-295807-68sukdb1	439	13	,	,	,
cord-295807-68sukdb1	439	14	H.pylori	H.pylori	NNP
cord-295807-68sukdb1	439	15	,	,	,
cord-295807-68sukdb1	439	16	in	in	IN
cord-295807-68sukdb1	439	17	the	the	DT
cord-295807-68sukdb1	439	18	stomach	stomach	NN
cord-295807-68sukdb1	439	19	also	also	RB
cord-295807-68sukdb1	439	20	depends	depend	VBZ
cord-295807-68sukdb1	439	21	on	on	IN
cord-295807-68sukdb1	439	22	urease	urease	JJ
cord-295807-68sukdb1	439	23	action	action	NN
cord-295807-68sukdb1	439	24	(	(	-LRB-
cord-295807-68sukdb1	439	25	see	see	VB
cord-295807-68sukdb1	439	26	section	section	NN
cord-295807-68sukdb1	439	27	4.7	4.7	CD
cord-295807-68sukdb1	439	28	)	)	-RRB-
cord-295807-68sukdb1	439	29	.	.	.
cord-295807-68sukdb1	440	1	Nephron	Nephron	NNP
cord-295807-68sukdb1	440	2	function	function	NN
cord-295807-68sukdb1	440	3	.	.	.
cord-295807-68sukdb1	441	1	Many	many	JJ
cord-295807-68sukdb1	441	2	studies	study	NNS
cord-295807-68sukdb1	441	3	point	point	VBP
cord-295807-68sukdb1	441	4	to	to	IN
cord-295807-68sukdb1	441	5	the	the	DT
cord-295807-68sukdb1	441	6	value	value	NN
cord-295807-68sukdb1	441	7	of	of	IN
cord-295807-68sukdb1	441	8	correcting	correct	VBG
cord-295807-68sukdb1	441	9	MAc	MAc	NNP
cord-295807-68sukdb1	441	10	for	for	IN
cord-295807-68sukdb1	441	11	preserving	preserve	VBG
cord-295807-68sukdb1	441	12	the	the	DT
cord-295807-68sukdb1	441	13	function	function	NN
cord-295807-68sukdb1	441	14	of	of	IN
cord-295807-68sukdb1	441	15	the	the	DT
cord-295807-68sukdb1	441	16	failing	fail	VBG
cord-295807-68sukdb1	441	17	kidney	kidney	NN
cord-295807-68sukdb1	441	18	and	and	CC
cord-295807-68sukdb1	441	19	slowing	slow	VBG
cord-295807-68sukdb1	441	20	CKD	CKD	NNP
cord-295807-68sukdb1	441	21	progression	progression	NN
cord-295807-68sukdb1	441	22	[	[	-LRB-
cord-295807-68sukdb1	441	23	264	264	CD
cord-295807-68sukdb1	441	24	]	]	-RRB-
cord-295807-68sukdb1	441	25	[	[	-LRB-
cord-295807-68sukdb1	441	26	265	265	CD
cord-295807-68sukdb1	441	27	]	]	-RRB-
cord-295807-68sukdb1	441	28	[	[	-LRB-
cord-295807-68sukdb1	441	29	266	266	CD
cord-295807-68sukdb1	441	30	]	]	-RRB-
cord-295807-68sukdb1	441	31	.	.	.
cord-295807-68sukdb1	442	1	We	-PRON-	PRP
cord-295807-68sukdb1	442	2	outlined	outline	VBD
cord-295807-68sukdb1	442	3	corrective	corrective	JJ
cord-295807-68sukdb1	442	4	strategies	strategy	NNS
cord-295807-68sukdb1	442	5	based	base	VBN
cord-295807-68sukdb1	442	6	around	around	IN
cord-295807-68sukdb1	442	7	alkali	alkali	NN
cord-295807-68sukdb1	442	8	therapy	therapy	NN
cord-295807-68sukdb1	442	9	in	in	IN
cord-295807-68sukdb1	442	10	section	section	NN
cord-295807-68sukdb1	442	11	3.2.2	3.2.2	NNP
cord-295807-68sukdb1	442	12	)	)	-RRB-
cord-295807-68sukdb1	442	13	,	,	,
cord-295807-68sukdb1	442	14	but	but	CC
cord-295807-68sukdb1	442	15	there	there	EX
cord-295807-68sukdb1	442	16	is	be	VBZ
cord-295807-68sukdb1	442	17	an	an	DT
cord-295807-68sukdb1	442	18	additional	additional	JJ
cord-295807-68sukdb1	442	19	prophylactic	prophylactic	JJ
cord-295807-68sukdb1	442	20	value	value	NN
cord-295807-68sukdb1	442	21	in	in	IN
cord-295807-68sukdb1	442	22	emergency	emergency	NN
cord-295807-68sukdb1	442	23	settings	setting	NNS
cord-295807-68sukdb1	442	24	.	.	.
cord-295807-68sukdb1	443	1	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	443	2	infusion	infusion	NN
cord-295807-68sukdb1	443	3	is	be	VBZ
cord-295807-68sukdb1	443	4	protective	protective	JJ
cord-295807-68sukdb1	443	5	against	against	IN
cord-295807-68sukdb1	443	6	the	the	DT
cord-295807-68sukdb1	443	7	kidney	kidney	NN
cord-295807-68sukdb1	443	8	damage	damage	NN
cord-295807-68sukdb1	443	9	that	that	WDT
cord-295807-68sukdb1	443	10	can	can	MD
cord-295807-68sukdb1	443	11	result	result	VB
cord-295807-68sukdb1	443	12	from	from	IN
cord-295807-68sukdb1	443	13	traumatic	traumatic	JJ
cord-295807-68sukdb1	443	14	rhabdomyolysis	rhabdomyolysis	NN
cord-295807-68sukdb1	443	15	(	(	-LRB-
cord-295807-68sukdb1	443	16	due	due	IN
cord-295807-68sukdb1	443	17	to	to	IN
cord-295807-68sukdb1	443	18	a	a	DT
cord-295807-68sukdb1	443	19	crush	crush	NN
cord-295807-68sukdb1	443	20	injury	injury	NN
cord-295807-68sukdb1	443	21	)	)	-RRB-
cord-295807-68sukdb1	443	22	,	,	,
cord-295807-68sukdb1	443	23	preventing	prevent	VBG
cord-295807-68sukdb1	443	24	development	development	NN
cord-295807-68sukdb1	443	25	of	of	IN
cord-295807-68sukdb1	443	26	MAc	MAc	NNP
cord-295807-68sukdb1	443	27	and	and	CC
cord-295807-68sukdb1	443	28	tempering	temper	VBG
cord-295807-68sukdb1	443	29	the	the	DT
cord-295807-68sukdb1	443	30	renal	renal	JJ
cord-295807-68sukdb1	443	31	toxicity	toxicity	NN
cord-295807-68sukdb1	443	32	of	of	IN
cord-295807-68sukdb1	443	33	myoglobin	myoglobin	NN
cord-295807-68sukdb1	443	34	[	[	-LRB-
cord-295807-68sukdb1	443	35	267	267	CD
cord-295807-68sukdb1	443	36	,	,	,
cord-295807-68sukdb1	443	37	268	268	CD
cord-295807-68sukdb1	443	38	]	]	-RRB-
cord-295807-68sukdb1	443	39	.	.	.
cord-295807-68sukdb1	444	1	Another	another	DT
cord-295807-68sukdb1	444	2	consideration	consideration	NN
cord-295807-68sukdb1	444	3	related	relate	VBN
cord-295807-68sukdb1	444	4	to	to	IN
cord-295807-68sukdb1	444	5	therapies	therapy	NNS
cord-295807-68sukdb1	444	6	is	be	VBZ
cord-295807-68sukdb1	444	7	that	that	IN
cord-295807-68sukdb1	444	8	a	a	DT
cord-295807-68sukdb1	444	9	number	number	NN
cord-295807-68sukdb1	444	10	of	of	IN
cord-295807-68sukdb1	444	11	drugs	drug	NNS
cord-295807-68sukdb1	444	12	cause	cause	VBP
cord-295807-68sukdb1	444	13	metabolic	metabolic	JJ
cord-295807-68sukdb1	444	14	acid	acid	NN
cord-295807-68sukdb1	444	15	-	-	HYPH
cord-295807-68sukdb1	444	16	base	base	NN
cord-295807-68sukdb1	444	17	disturbances	disturbance	NNS
cord-295807-68sukdb1	444	18	because	because	IN
cord-295807-68sukdb1	444	19	they	-PRON-	PRP
cord-295807-68sukdb1	444	20	are	be	VBP
cord-295807-68sukdb1	444	21	nephrotoxic	nephrotoxic	JJ
cord-295807-68sukdb1	444	22	[	[	-LRB-
cord-295807-68sukdb1	444	23	269	269	CD
cord-295807-68sukdb1	444	24	]	]	-RRB-
cord-295807-68sukdb1	444	25	or	or	CC
cord-295807-68sukdb1	444	26	incidentally	incidentally	RB
cord-295807-68sukdb1	444	27	interfere	interfere	VB
cord-295807-68sukdb1	444	28	with	with	IN
cord-295807-68sukdb1	444	29	the	the	DT
cord-295807-68sukdb1	444	30	kidneys	kidney	NNS
cord-295807-68sukdb1	444	31	ability	ability	NN
cord-295807-68sukdb1	444	32	to	to	TO
cord-295807-68sukdb1	444	33	excrete	excrete	VB
cord-295807-68sukdb1	444	34	acid	acid	NN
cord-295807-68sukdb1	444	35	[	[	-LRB-
cord-295807-68sukdb1	444	36	55	55	CD
cord-295807-68sukdb1	444	37	]	]	-RRB-
cord-295807-68sukdb1	444	38	.	.	.
cord-295807-68sukdb1	445	1	For	for	IN
cord-295807-68sukdb1	445	2	example	example	NN
cord-295807-68sukdb1	445	3	,	,	,
cord-295807-68sukdb1	445	4	CA	CA	NNP
cord-295807-68sukdb1	445	5	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	445	6	such	such	JJ
cord-295807-68sukdb1	445	7	as	as	IN
cord-295807-68sukdb1	445	8	ACZ	ACZ	NNP
cord-295807-68sukdb1	445	9	that	that	WDT
cord-295807-68sukdb1	445	10	are	be	VBP
cord-295807-68sukdb1	445	11	used	use	VBN
cord-295807-68sukdb1	445	12	as	as	IN
cord-295807-68sukdb1	445	13	diuretics	diuretic	NNS
cord-295807-68sukdb1	445	14	,	,	,
cord-295807-68sukdb1	445	15	due	due	IN
cord-295807-68sukdb1	445	16	to	to	IN
cord-295807-68sukdb1	445	17	their	-PRON-	PRP$
cord-295807-68sukdb1	445	18	ability	ability	NN
cord-295807-68sukdb1	445	19	to	to	TO
cord-295807-68sukdb1	445	20	interfere	interfere	VB
cord-295807-68sukdb1	445	21	with	with	IN
cord-295807-68sukdb1	445	22	fluid	fluid	JJ
cord-295807-68sukdb1	445	23	reabsorption	reabsorption	NN
cord-295807-68sukdb1	445	24	,	,	,
cord-295807-68sukdb1	445	25	also	also	RB
cord-295807-68sukdb1	445	26	cause	cause	VB
cord-295807-68sukdb1	445	27	MAc	MAc	NNP
cord-295807-68sukdb1	445	28	[	[	-LRB-
cord-295807-68sukdb1	445	29	270	270	CD
cord-295807-68sukdb1	445	30	]	]	-RRB-
cord-295807-68sukdb1	445	31	.	.	.
cord-295807-68sukdb1	446	1	On	on	IN
cord-295807-68sukdb1	446	2	the	the	DT
cord-295807-68sukdb1	446	3	other	other	JJ
cord-295807-68sukdb1	446	4	hand	hand	NN
cord-295807-68sukdb1	446	5	,	,	,
cord-295807-68sukdb1	446	6	loop	loop	NN
cord-295807-68sukdb1	446	7	diuretics	diuretic	NNS
cord-295807-68sukdb1	446	8	use	use	VBP
cord-295807-68sukdb1	446	9	can	can	MD
cord-295807-68sukdb1	446	10	cause	cause	VB
cord-295807-68sukdb1	446	11	MAlk	MAlk	NNP
cord-295807-68sukdb1	446	12	[	[	-LRB-
cord-295807-68sukdb1	446	13	271	271	CD
cord-295807-68sukdb1	446	14	]	]	-RRB-
cord-295807-68sukdb1	446	15	.	.	.
cord-295807-68sukdb1	447	1	Another	another	DT
cord-295807-68sukdb1	447	2	example	example	NN
cord-295807-68sukdb1	447	3	are	be	VBP
cord-295807-68sukdb1	447	4	penicillin	penicillin	NN
cord-295807-68sukdb1	447	5	antibiotics	antibiotic	NNS
cord-295807-68sukdb1	447	6	which	which	WDT
cord-295807-68sukdb1	447	7	,	,	,
cord-295807-68sukdb1	447	8	acting	act	VBG
cord-295807-68sukdb1	447	9	as	as	IN
cord-295807-68sukdb1	447	10	significant	significant	JJ
cord-295807-68sukdb1	447	11	non	non	JJ
cord-295807-68sukdb1	447	12	-	-	JJ
cord-295807-68sukdb1	447	13	reabsorbed	reabsorbed	JJ
cord-295807-68sukdb1	447	14	anions	anion	NNS
cord-295807-68sukdb1	447	15	in	in	IN
cord-295807-68sukdb1	447	16	the	the	DT
cord-295807-68sukdb1	447	17	collecting	collecting	NN
cord-295807-68sukdb1	447	18	duct	duct	NN
cord-295807-68sukdb1	447	19	lumen	lumen	NN
cord-295807-68sukdb1	447	20	,	,	,
cord-295807-68sukdb1	447	21	promote	promote	VB
cord-295807-68sukdb1	447	22	hypersecretion	hypersecretion	NN
cord-295807-68sukdb1	447	23	of	of	IN
cord-295807-68sukdb1	447	24	K	K	NNP
cord-295807-68sukdb1	447	25	+	+	CC
cord-295807-68sukdb1	447	26	and	and	CC
cord-295807-68sukdb1	447	27	H	H	NNP
cord-295807-68sukdb1	447	28	+	+	CC
cord-295807-68sukdb1	447	29	,	,	,
cord-295807-68sukdb1	447	30	resulting	result	VBG
cord-295807-68sukdb1	447	31	in	in	IN
cord-295807-68sukdb1	447	32	hypokalemia	hypokalemia	NN
cord-295807-68sukdb1	447	33	and	and	CC
cord-295807-68sukdb1	447	34	MAlk	MAlk	NNP
cord-295807-68sukdb1	447	35	[	[	-LRB-
cord-295807-68sukdb1	447	36	272	272	CD
cord-295807-68sukdb1	447	37	,	,	,
cord-295807-68sukdb1	447	38	273	273	CD
cord-295807-68sukdb1	447	39	]	]	-RRB-
cord-295807-68sukdb1	447	40	.	.	.
cord-295807-68sukdb1	448	1	Finally	finally	RB
cord-295807-68sukdb1	448	2	in	in	IN
cord-295807-68sukdb1	448	3	this	this	DT
cord-295807-68sukdb1	448	4	section	section	NN
cord-295807-68sukdb1	448	5	,	,	,
cord-295807-68sukdb1	448	6	the	the	DT
cord-295807-68sukdb1	448	7	ability	ability	NN
cord-295807-68sukdb1	448	8	of	of	IN
cord-295807-68sukdb1	448	9	CF	cf	NN
cord-295807-68sukdb1	448	10	kidneys	kidney	NNS
cord-295807-68sukdb1	448	11	to	to	TO
cord-295807-68sukdb1	448	12	secrete	secrete	VB
cord-295807-68sukdb1	448	13	excess	excess	JJ
cord-295807-68sukdb1	448	14	HCO3is	HCO3is	NNP
cord-295807-68sukdb1	448	15	restored	restore	VBN
cord-295807-68sukdb1	448	16	by	by	IN
cord-295807-68sukdb1	448	17	treatment	treatment	NN
cord-295807-68sukdb1	448	18	with	with	IN
cord-295807-68sukdb1	448	19	the	the	DT
cord-295807-68sukdb1	448	20	CFTR	CFTR	NNP
cord-295807-68sukdb1	448	21	restoring	restore	VBG
cord-295807-68sukdb1	448	22	drug	drug	NN
cord-295807-68sukdb1	448	23	cocktail	cocktail	NN
cord-295807-68sukdb1	448	24	lumacaftor	lumacaftor	NN
cord-295807-68sukdb1	448	25	/	/	SYM
cord-295807-68sukdb1	448	26	ivacaftor	ivacaftor	NNP
cord-295807-68sukdb1	448	27	(	(	-LRB-
cord-295807-68sukdb1	448	28	ORKAMBI	ORKAMBI	NNP
cord-295807-68sukdb1	449	1	®	®	LS
cord-295807-68sukdb1	449	2	)	)	-RRB-
cord-295807-68sukdb1	449	3	[	[	-LRB-
cord-295807-68sukdb1	449	4	274	274	CD
cord-295807-68sukdb1	449	5	]	]	-RRB-
cord-295807-68sukdb1	449	6	.	.	.
cord-295807-68sukdb1	450	1	Stone	stone	NN
cord-295807-68sukdb1	450	2	formation	formation	NN
cord-295807-68sukdb1	450	3	.	.	.
cord-295807-68sukdb1	451	1	Both	both	DT
cord-295807-68sukdb1	451	2	citrate	citrate	NN
cord-295807-68sukdb1	451	3	and	and	CC
cord-295807-68sukdb1	451	4	low	low	JJ
cord-295807-68sukdb1	451	5	pH	pH	NNP
cord-295807-68sukdb1	451	6	discourage	discourage	VB
cord-295807-68sukdb1	451	7	the	the	DT
cord-295807-68sukdb1	451	8	formation	formation	NN
cord-295807-68sukdb1	451	9	of	of	IN
cord-295807-68sukdb1	451	10	calcium	calcium	NN
cord-295807-68sukdb1	451	11	precipitates	precipitate	VBZ
cord-295807-68sukdb1	451	12	[	[	-LRB-
cord-295807-68sukdb1	451	13	275	275	CD
cord-295807-68sukdb1	451	14	]	]	-RRB-
cord-295807-68sukdb1	451	15	.	.	.
cord-295807-68sukdb1	452	1	Thus	thus	RB
cord-295807-68sukdb1	452	2	,	,	,
cord-295807-68sukdb1	452	3	ingesting	ingest	VBG
cord-295807-68sukdb1	452	4	lemon	lemon	NN
cord-295807-68sukdb1	452	5	juice	juice	NN
cord-295807-68sukdb1	452	6	,	,	,
cord-295807-68sukdb1	452	7	which	which	WDT
cord-295807-68sukdb1	452	8	raises	raise	VBZ
cord-295807-68sukdb1	452	9	urinary	urinary	JJ
cord-295807-68sukdb1	452	10	citrate	citrate	NN
cord-295807-68sukdb1	452	11	while	while	IN
cord-295807-68sukdb1	452	12	lowering	lower	VBG
cord-295807-68sukdb1	452	13	urinary	urinary	JJ
cord-295807-68sukdb1	452	14	pH	pH	NNP
cord-295807-68sukdb1	452	15	,	,	,
cord-295807-68sukdb1	452	16	decreases	decrease	VBZ
cord-295807-68sukdb1	452	17	the	the	DT
cord-295807-68sukdb1	452	18	propensity	propensity	NN
cord-295807-68sukdb1	452	19	to	to	TO
cord-295807-68sukdb1	452	20	form	form	VB
cord-295807-68sukdb1	452	21	kidney	kidney	NN
cord-295807-68sukdb1	452	22	stones	stone	NNS
cord-295807-68sukdb1	452	23	and	and	CC
cord-295807-68sukdb1	452	24	catheter	catheter	NN
cord-295807-68sukdb1	452	25	-	-	HYPH
cord-295807-68sukdb1	452	26	blocking	block	VBG
cord-295807-68sukdb1	452	27	deposits	deposit	NNS
cord-295807-68sukdb1	452	28	[	[	-LRB-
cord-295807-68sukdb1	452	29	276	276	CD
cord-295807-68sukdb1	452	30	]	]	-RRB-
cord-295807-68sukdb1	452	31	.	.	.
cord-295807-68sukdb1	453	1	Dietary	dietary	JJ
cord-295807-68sukdb1	453	2	supplementation	supplementation	NN
cord-295807-68sukdb1	453	3	with	with	IN
cord-295807-68sukdb1	453	4	citrate	citrate	NN
cord-295807-68sukdb1	453	5	salts	salt	NNS
cord-295807-68sukdb1	453	6	is	be	VBZ
cord-295807-68sukdb1	453	7	also	also	RB
cord-295807-68sukdb1	453	8	effective	effective	JJ
cord-295807-68sukdb1	453	9	for	for	IN
cord-295807-68sukdb1	453	10	this	this	DT
cord-295807-68sukdb1	453	11	purpose	purpose	NN
cord-295807-68sukdb1	453	12	because	because	IN
cord-295807-68sukdb1	453	13	,	,	,
cord-295807-68sukdb1	453	14	despite	despite	IN
cord-295807-68sukdb1	453	15	resulting	result	VBG
cord-295807-68sukdb1	453	16	in	in	IN
cord-295807-68sukdb1	453	17	a	a	DT
cord-295807-68sukdb1	453	18	rise	rise	NN
cord-295807-68sukdb1	453	19	in	in	IN
cord-295807-68sukdb1	453	20	urinary	urinary	JJ
cord-295807-68sukdb1	453	21	pH	ph	NN
cord-295807-68sukdb1	453	22	,	,	,
cord-295807-68sukdb1	453	23	the	the	DT
cord-295807-68sukdb1	453	24	accompanying	accompany	VBG
cord-295807-68sukdb1	453	25	rise	rise	NN
cord-295807-68sukdb1	453	26	in	in	IN
cord-295807-68sukdb1	453	27	urinary	urinary	JJ
cord-295807-68sukdb1	453	28	citrate	citrate	NN
cord-295807-68sukdb1	453	29	increases	increase	VBZ
cord-295807-68sukdb1	453	30	the	the	DT
cord-295807-68sukdb1	453	31	pH	pH	NNP
cord-295807-68sukdb1	453	32	of	of	IN
cord-295807-68sukdb1	453	33	crystal	crystal	JJ
cord-295807-68sukdb1	453	34	nucleation	nucleation	NN
cord-295807-68sukdb1	453	35	to	to	IN
cord-295807-68sukdb1	453	36	an	an	DT
cord-295807-68sukdb1	453	37	even	even	RB
cord-295807-68sukdb1	453	38	higher	high	JJR
cord-295807-68sukdb1	453	39	value	value	NN
cord-295807-68sukdb1	453	40	[	[	-LRB-
cord-295807-68sukdb1	453	41	277	277	CD
cord-295807-68sukdb1	453	42	,	,	,
cord-295807-68sukdb1	453	43	278	278	CD
cord-295807-68sukdb1	453	44	]	]	-RRB-
cord-295807-68sukdb1	453	45	.	.	.
cord-295807-68sukdb1	454	1	Urinary	urinary	JJ
cord-295807-68sukdb1	454	2	pH	pH	NNP
cord-295807-68sukdb1	454	3	can	can	MD
cord-295807-68sukdb1	454	4	also	also	RB
cord-295807-68sukdb1	454	5	exert	exert	VB
cord-295807-68sukdb1	454	6	a	a	DT
cord-295807-68sukdb1	454	7	meaningful	meaningful	JJ
cord-295807-68sukdb1	454	8	influence	influence	NN
cord-295807-68sukdb1	454	9	on	on	IN
cord-295807-68sukdb1	454	10	drug	drug	NN
cord-295807-68sukdb1	454	11	excretion	excretion	NN
cord-295807-68sukdb1	454	12	as	as	IN
cord-295807-68sukdb1	454	13	discussed	discuss	VBN
cord-295807-68sukdb1	454	14	later	later	RB
cord-295807-68sukdb1	454	15	(	(	-LRB-
cord-295807-68sukdb1	454	16	see	see	VB
cord-295807-68sukdb1	454	17	section	section	NN
cord-295807-68sukdb1	454	18	6.5	6.5	CD
cord-295807-68sukdb1	454	19	)	)	-RRB-
cord-295807-68sukdb1	454	20	.	.	.
cord-295807-68sukdb1	455	1	At	at	IN
cord-295807-68sukdb1	455	2	this	this	DT
cord-295807-68sukdb1	455	3	point	point	NN
cord-295807-68sukdb1	455	4	in	in	IN
cord-295807-68sukdb1	455	5	our	-PRON-	PRP$
cord-295807-68sukdb1	455	6	review	review	NN
cord-295807-68sukdb1	455	7	we	-PRON-	PRP
cord-295807-68sukdb1	455	8	have	have	VBP
cord-295807-68sukdb1	455	9	presented	present	VBN
cord-295807-68sukdb1	455	10	ample	ample	JJ
cord-295807-68sukdb1	455	11	evidence	evidence	NN
cord-295807-68sukdb1	455	12	that	that	IN
cord-295807-68sukdb1	455	13	ABTs	abt	NNS
cord-295807-68sukdb1	455	14	are	be	VBP
cord-295807-68sukdb1	455	15	necessary	necessary	JJ
cord-295807-68sukdb1	455	16	to	to	TO
cord-295807-68sukdb1	455	17	sustain	sustain	VB
cord-295807-68sukdb1	455	18	life	life	NN
cord-295807-68sukdb1	455	19	,	,	,
cord-295807-68sukdb1	455	20	and	and	CC
cord-295807-68sukdb1	455	21	now	now	RB
cord-295807-68sukdb1	455	22	we	-PRON-	PRP
cord-295807-68sukdb1	455	23	will	will	MD
cord-295807-68sukdb1	455	24	see	see	VB
cord-295807-68sukdb1	455	25	that	that	IN
cord-295807-68sukdb1	455	26	they	-PRON-	PRP
cord-295807-68sukdb1	455	27	are	be	VBP
cord-295807-68sukdb1	455	28	also	also	RB
cord-295807-68sukdb1	455	29	necessary	necessary	JJ
cord-295807-68sukdb1	455	30	to	to	TO
cord-295807-68sukdb1	455	31	create	create	VB
cord-295807-68sukdb1	455	32	new	new	JJ
cord-295807-68sukdb1	455	33	life	life	NN
cord-295807-68sukdb1	455	34	.	.	.
cord-295807-68sukdb1	456	1	In	in	IN
cord-295807-68sukdb1	456	2	the	the	DT
cord-295807-68sukdb1	456	3	male	male	JJ
cord-295807-68sukdb1	456	4	reproductive	reproductive	JJ
cord-295807-68sukdb1	456	5	tract	tract	NN
cord-295807-68sukdb1	456	6	,	,	,
cord-295807-68sukdb1	456	7	H	h	NN
cord-295807-68sukdb1	456	8	+	+	CC
cord-295807-68sukdb1	456	9	secretion	secretion	NN
cord-295807-68sukdb1	456	10	by	by	IN
cord-295807-68sukdb1	456	11	clear	clear	JJ
cord-295807-68sukdb1	456	12	cells	cell	NNS
cord-295807-68sukdb1	456	13	in	in	IN
cord-295807-68sukdb1	456	14	the	the	DT
cord-295807-68sukdb1	456	15	tail	tail	NN
cord-295807-68sukdb1	456	16	of	of	IN
cord-295807-68sukdb1	456	17	the	the	DT
cord-295807-68sukdb1	456	18	epididymis	epididymis	NN
cord-295807-68sukdb1	456	19	is	be	VBZ
cord-295807-68sukdb1	456	20	required	require	VBN
cord-295807-68sukdb1	456	21	to	to	TO
cord-295807-68sukdb1	456	22	maintain	maintain	VB
cord-295807-68sukdb1	456	23	an	an	DT
cord-295807-68sukdb1	456	24	acidic	acidic	JJ
cord-295807-68sukdb1	456	25	luminal	luminal	JJ
cord-295807-68sukdb1	456	26	pH	ph	NN
cord-295807-68sukdb1	456	27	for	for	IN
cord-295807-68sukdb1	456	28	storage	storage	NN
cord-295807-68sukdb1	456	29	of	of	IN
cord-295807-68sukdb1	456	30	sperm	sperm	NN
cord-295807-68sukdb1	456	31	[	[	-LRB-
cord-295807-68sukdb1	456	32	279	279	CD
cord-295807-68sukdb1	456	33	]	]	-RRB-
cord-295807-68sukdb1	456	34	.	.	.
cord-295807-68sukdb1	457	1	HCO3secretion	hco3secretion	NN
cord-295807-68sukdb1	457	2	along	along	IN
cord-295807-68sukdb1	457	3	the	the	DT
cord-295807-68sukdb1	457	4	length	length	NN
cord-295807-68sukdb1	457	5	of	of	IN
cord-295807-68sukdb1	457	6	epididymis	epididymis	NN
cord-295807-68sukdb1	457	7	is	be	VBZ
cord-295807-68sukdb1	457	8	necessary	necessary	JJ
cord-295807-68sukdb1	457	9	to	to	TO
cord-295807-68sukdb1	457	10	functionally	functionally	RB
cord-295807-68sukdb1	457	11	activate	activate	VB
cord-295807-68sukdb1	457	12	sperm	sperm	NN
cord-295807-68sukdb1	457	13	before	before	IN
cord-295807-68sukdb1	457	14	ejaculation	ejaculation	NN
cord-295807-68sukdb1	457	15	[	[	-LRB-
cord-295807-68sukdb1	457	16	280	280	CD
cord-295807-68sukdb1	457	17	]	]	-RRB-
cord-295807-68sukdb1	457	18	and	and	CC
cord-295807-68sukdb1	457	19	prevent	prevent	VB
cord-295807-68sukdb1	457	20	their	-PRON-	PRP$
cord-295807-68sukdb1	457	21	inactivation	inactivation	NN
cord-295807-68sukdb1	457	22	by	by	IN
cord-295807-68sukdb1	457	23	the	the	DT
cord-295807-68sukdb1	457	24	acidic	acidic	JJ
cord-295807-68sukdb1	457	25	vaginal	vaginal	JJ
cord-295807-68sukdb1	457	26	environment	environment	NN
cord-295807-68sukdb1	457	27	(	(	-LRB-
cord-295807-68sukdb1	457	28	discussed	discuss	VBN
cord-295807-68sukdb1	457	29	later	later	RB
cord-295807-68sukdb1	457	30	)	)	-RRB-
cord-295807-68sukdb1	457	31	.	.	.
cord-295807-68sukdb1	458	1	Indeed	indeed	RB
cord-295807-68sukdb1	458	2	low	low	JJ
cord-295807-68sukdb1	458	3	levels	level	NNS
cord-295807-68sukdb1	458	4	of	of	IN
cord-295807-68sukdb1	458	5	HCO3are	hco3are	NN
cord-295807-68sukdb1	458	6	associated	associate	VBN
cord-295807-68sukdb1	458	7	with	with	IN
cord-295807-68sukdb1	458	8	lowered	lower	VBN
cord-295807-68sukdb1	458	9	sperm	sperm	NN
cord-295807-68sukdb1	458	10	motility	motility	NN
cord-295807-68sukdb1	458	11	[	[	-LRB-
cord-295807-68sukdb1	458	12	281	281	CD
cord-295807-68sukdb1	458	13	]	]	-RRB-
cord-295807-68sukdb1	458	14	.	.	.
cord-295807-68sukdb1	459	1	In	in	IN
cord-295807-68sukdb1	459	2	the	the	DT
cord-295807-68sukdb1	459	3	female	female	JJ
cord-295807-68sukdb1	459	4	reproductive	reproductive	JJ
cord-295807-68sukdb1	459	5	tract	tract	NN
cord-295807-68sukdb1	459	6	,	,	,
cord-295807-68sukdb1	459	7	endometrial	endometrial	JJ
cord-295807-68sukdb1	459	8	epithelial	epithelial	JJ
cord-295807-68sukdb1	459	9	cells	cell	NNS
cord-295807-68sukdb1	459	10	further	further	RB
cord-295807-68sukdb1	459	11	secrete	secrete	VBP
cord-295807-68sukdb1	459	12	a	a	DT
cord-295807-68sukdb1	459	13	HCO3	HCO3	NNP
cord-295807-68sukdb1	459	14	--rich	--rich	NN
cord-295807-68sukdb1	459	15	fluid	fluid	NN
cord-295807-68sukdb1	459	16	that	that	WDT
cord-295807-68sukdb1	459	17	is	be	VBZ
cord-295807-68sukdb1	459	18	necessary	necessary	JJ
cord-295807-68sukdb1	459	19	for	for	IN
cord-295807-68sukdb1	459	20	sperm	sperm	NN
cord-295807-68sukdb1	459	21	capacitation	capacitation	NN
cord-295807-68sukdb1	459	22	and	and	CC
cord-295807-68sukdb1	459	23	fertilization	fertilization	NN
cord-295807-68sukdb1	459	24	[	[	-LRB-
cord-295807-68sukdb1	459	25	282	282	CD
cord-295807-68sukdb1	459	26	]	]	-RRB-
cord-295807-68sukdb1	459	27	.	.	.
cord-295807-68sukdb1	460	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	460	2	,	,	,
cord-295807-68sukdb1	460	3	the	the	DT
cord-295807-68sukdb1	460	4	secretory	secretory	JJ
cord-295807-68sukdb1	460	5	phase	phase	NN
cord-295807-68sukdb1	460	6	of	of	IN
cord-295807-68sukdb1	460	7	the	the	DT
cord-295807-68sukdb1	460	8	uterine	uterine	JJ
cord-295807-68sukdb1	460	9	cycle	cycle	NN
cord-295807-68sukdb1	460	10	is	be	VBZ
cord-295807-68sukdb1	460	11	associated	associate	VBN
cord-295807-68sukdb1	460	12	with	with	IN
cord-295807-68sukdb1	460	13	a	a	DT
cord-295807-68sukdb1	460	14	dramatic	dramatic	JJ
cord-295807-68sukdb1	460	15	rise	rise	NN
cord-295807-68sukdb1	460	16	in	in	IN
cord-295807-68sukdb1	460	17	the	the	DT
cord-295807-68sukdb1	460	18	pH	ph	NN
cord-295807-68sukdb1	460	19	of	of	IN
cord-295807-68sukdb1	460	20	the	the	DT
cord-295807-68sukdb1	460	21	oviduct	oviduct	NN
cord-295807-68sukdb1	460	22	lumen	lumen	NN
cord-295807-68sukdb1	460	23	,	,	,
cord-295807-68sukdb1	460	24	corresponding	correspond	VBG
cord-295807-68sukdb1	460	25	with	with	IN
cord-295807-68sukdb1	460	26	a	a	DT
cord-295807-68sukdb1	460	27	level	level	NN
cord-295807-68sukdb1	460	28	of	of	IN
cord-295807-68sukdb1	460	29	HCO3that	HCO3that	NNP
cord-295807-68sukdb1	460	30	is	be	VBZ
cord-295807-68sukdb1	460	31	sufficient	sufficient	JJ
cord-295807-68sukdb1	460	32	to	to	TO
cord-295807-68sukdb1	460	33	promote	promote	VB
cord-295807-68sukdb1	460	34	thinning	thinning	NN
cord-295807-68sukdb1	460	35	of	of	IN
cord-295807-68sukdb1	460	36	mucus	mucus	NN
cord-295807-68sukdb1	460	37	during	during	IN
cord-295807-68sukdb1	460	38	ovulation	ovulation	NN
cord-295807-68sukdb1	460	39	to	to	TO
cord-295807-68sukdb1	460	40	promote	promote	VB
cord-295807-68sukdb1	460	41	sperm	sperm	NN
cord-295807-68sukdb1	460	42	mobility	mobility	NN
cord-295807-68sukdb1	460	43	[	[	-LRB-
cord-295807-68sukdb1	460	44	283	283	CD
cord-295807-68sukdb1	460	45	]	]	-RRB-
cord-295807-68sukdb1	460	46	and	and	CC
cord-295807-68sukdb1	460	47	to	to	TO
cord-295807-68sukdb1	460	48	promote	promote	VB
cord-295807-68sukdb1	460	49	dispersal	dispersal	NN
cord-295807-68sukdb1	460	50	of	of	IN
cord-295807-68sukdb1	460	51	the	the	DT
cord-295807-68sukdb1	460	52	egg	egg	NN
cord-295807-68sukdb1	460	53	-	-	HYPH
cord-295807-68sukdb1	460	54	surrounding	surround	VBG
cord-295807-68sukdb1	460	55	corona	corona	NN
cord-295807-68sukdb1	460	56	cells	cell	NNS
cord-295807-68sukdb1	460	57	to	to	TO
cord-295807-68sukdb1	460	58	allow	allow	VB
cord-295807-68sukdb1	460	59	the	the	DT
cord-295807-68sukdb1	460	60	sperm	sperm	NN
cord-295807-68sukdb1	460	61	access	access	NN
cord-295807-68sukdb1	460	62	for	for	IN
cord-295807-68sukdb1	460	63	fertilization	fertilization	NN
cord-295807-68sukdb1	460	64	[	[	-LRB-
cord-295807-68sukdb1	460	65	284	284	CD
cord-295807-68sukdb1	460	66	]	]	-RRB-
cord-295807-68sukdb1	460	67	.	.	.
cord-295807-68sukdb1	461	1	Ultimately	ultimately	RB
cord-295807-68sukdb1	461	2	HCO3is	HCO3is	NNP
cord-295807-68sukdb1	461	3	even	even	RB
cord-295807-68sukdb1	461	4	a	a	DT
cord-295807-68sukdb1	461	5	prerequisite	prerequisite	NN
cord-295807-68sukdb1	461	6	for	for	IN
cord-295807-68sukdb1	461	7	the	the	DT
cord-295807-68sukdb1	461	8	acrosome	acrosome	NN
cord-295807-68sukdb1	461	9	reaction	reaction	NN
cord-295807-68sukdb1	461	10	[	[	-LRB-
cord-295807-68sukdb1	461	11	285	285	CD
cord-295807-68sukdb1	461	12	]	]	-RRB-
cord-295807-68sukdb1	461	13	,	,	,
cord-295807-68sukdb1	461	14	by	by	IN
cord-295807-68sukdb1	461	15	virtue	virtue	NN
cord-295807-68sukdb1	461	16	of	of	IN
cord-295807-68sukdb1	461	17	its	-PRON-	PRP$
cord-295807-68sukdb1	461	18	ability	ability	NN
cord-295807-68sukdb1	461	19	to	to	TO
cord-295807-68sukdb1	461	20	stimulate	stimulate	VB
cord-295807-68sukdb1	461	21	soluble	soluble	JJ
cord-295807-68sukdb1	461	22	adenylyl	adenylyl	JJ
cord-295807-68sukdb1	461	23	cyclase	cyclase	NN
cord-295807-68sukdb1	461	24	to	to	TO
cord-295807-68sukdb1	461	25	produce	produce	VB
cord-295807-68sukdb1	461	26	cAMP	camp	NN
cord-295807-68sukdb1	461	27	and	and	CC
cord-295807-68sukdb1	461	28	initiate	initiate	VB
cord-295807-68sukdb1	461	29	requisite	requisite	JJ
cord-295807-68sukdb1	461	30	signaling	signaling	NN
cord-295807-68sukdb1	461	31	cascades	cascade	NNS
cord-295807-68sukdb1	461	32	[	[	-LRB-
cord-295807-68sukdb1	461	33	286	286	CD
cord-295807-68sukdb1	461	34	]	]	-RRB-
cord-295807-68sukdb1	461	35	.	.	.
cord-295807-68sukdb1	462	1	Finally	finally	RB
cord-295807-68sukdb1	462	2	,	,	,
cord-295807-68sukdb1	462	3	once	once	IN
cord-295807-68sukdb1	462	4	fertilization	fertilization	NN
cord-295807-68sukdb1	462	5	has	have	VBZ
cord-295807-68sukdb1	462	6	occurred	occur	VBN
cord-295807-68sukdb1	462	7	,	,	,
cord-295807-68sukdb1	462	8	acidification	acidification	NN
cord-295807-68sukdb1	462	9	of	of	IN
cord-295807-68sukdb1	462	10	uterine	uterine	JJ
cord-295807-68sukdb1	462	11	fluid	fluid	NN
cord-295807-68sukdb1	462	12	is	be	VBZ
cord-295807-68sukdb1	462	13	a	a	DT
cord-295807-68sukdb1	462	14	necessary	necessary	JJ
cord-295807-68sukdb1	462	15	prerequisite	prerequisite	NN
cord-295807-68sukdb1	462	16	for	for	IN
cord-295807-68sukdb1	462	17	embryo	embryo	NN
cord-295807-68sukdb1	462	18	implantation	implantation	NN
cord-295807-68sukdb1	462	19	[	[	-LRB-
cord-295807-68sukdb1	462	20	287	287	CD
cord-295807-68sukdb1	462	21	]	]	-RRB-
cord-295807-68sukdb1	462	22	.	.	.
cord-295807-68sukdb1	463	1	Numerous	numerous	JJ
cord-295807-68sukdb1	463	2	ABTs	abt	NNS
cord-295807-68sukdb1	463	3	are	be	VBP
cord-295807-68sukdb1	463	4	involved	involve	VBN
cord-295807-68sukdb1	463	5	in	in	IN
cord-295807-68sukdb1	463	6	these	these	DT
cord-295807-68sukdb1	463	7	processes	process	NNS
cord-295807-68sukdb1	463	8	;	;	:
cord-295807-68sukdb1	463	9	for	for	IN
cord-295807-68sukdb1	463	10	example	example	NN
cord-295807-68sukdb1	463	11	,	,	,
cord-295807-68sukdb1	463	12	loss	loss	NN
cord-295807-68sukdb1	463	13	of	of	IN
cord-295807-68sukdb1	463	14	AE2	AE2	NNP
cord-295807-68sukdb1	463	15	,	,	,
cord-295807-68sukdb1	463	16	SLC26A3	slc26a3	NN
cord-295807-68sukdb1	463	17	,	,	,
cord-295807-68sukdb1	463	18	CFTR	CFTR	NNP
cord-295807-68sukdb1	463	19	,	,	,
cord-295807-68sukdb1	463	20	or	or	CC
cord-295807-68sukdb1	463	21	NHE8	NHE8	NNP
cord-295807-68sukdb1	463	22	are	be	VBP
cord-295807-68sukdb1	463	23	all	all	RB
cord-295807-68sukdb1	463	24	associated	associate	VBN
cord-295807-68sukdb1	463	25	with	with	IN
cord-295807-68sukdb1	463	26	infertility	infertility	NN
cord-295807-68sukdb1	463	27	or	or	CC
cord-295807-68sukdb1	463	28	reduced	reduce	VBN
cord-295807-68sukdb1	463	29	fertility	fertility	NN
cord-295807-68sukdb1	463	30	in	in	IN
cord-295807-68sukdb1	463	31	male	male	JJ
cord-295807-68sukdb1	463	32	mice	mouse	NNS
cord-295807-68sukdb1	463	33	[	[	-LRB-
cord-295807-68sukdb1	463	34	282	282	CD
cord-295807-68sukdb1	463	35	,	,	,
cord-295807-68sukdb1	463	36	[	[	-LRB-
cord-295807-68sukdb1	463	37	288	288	CD
cord-295807-68sukdb1	463	38	]	]	-RRB-
cord-295807-68sukdb1	463	39	[	[	-LRB-
cord-295807-68sukdb1	463	40	289	289	CD
cord-295807-68sukdb1	463	41	]	]	-RRB-
cord-295807-68sukdb1	463	42	[	[	-LRB-
cord-295807-68sukdb1	463	43	290	290	CD
cord-295807-68sukdb1	463	44	]	]	-RRB-
cord-295807-68sukdb1	463	45	.	.	.
cord-295807-68sukdb1	464	1	The	the	DT
cord-295807-68sukdb1	464	2	acidic	acidic	JJ
cord-295807-68sukdb1	464	3	pH	ph	NN
cord-295807-68sukdb1	464	4	of	of	IN
cord-295807-68sukdb1	464	5	the	the	DT
cord-295807-68sukdb1	464	6	vagina	vagina	NN
cord-295807-68sukdb1	464	7	noted	note	VBN
cord-295807-68sukdb1	464	8	earlier	early	RBR
cord-295807-68sukdb1	464	9	is	be	VBZ
cord-295807-68sukdb1	464	10	caused	cause	VBN
cord-295807-68sukdb1	464	11	by	by	IN
cord-295807-68sukdb1	464	12	the	the	DT
cord-295807-68sukdb1	464	13	metabolic	metabolic	JJ
cord-295807-68sukdb1	464	14	activity	activity	NN
cord-295807-68sukdb1	464	15	of	of	IN
cord-295807-68sukdb1	464	16	lactobacilli	lactobacilli	NN
cord-295807-68sukdb1	464	17	and	and	CC
cord-295807-68sukdb1	464	18	serves	serve	VBZ
cord-295807-68sukdb1	464	19	to	to	TO
cord-295807-68sukdb1	464	20	defend	defend	VB
cord-295807-68sukdb1	464	21	against	against	IN
cord-295807-68sukdb1	464	22	sexually	sexually	RB
cord-295807-68sukdb1	464	23	transmitted	transmit	VBN
cord-295807-68sukdb1	464	24	disease	disease	NN
cord-295807-68sukdb1	464	25	pathogens	pathogen	NNS
cord-295807-68sukdb1	464	26	.	.	.
cord-295807-68sukdb1	465	1	Loss	loss	NN
cord-295807-68sukdb1	465	2	of	of	IN
cord-295807-68sukdb1	465	3	the	the	DT
cord-295807-68sukdb1	465	4	acidity	acidity	NN
cord-295807-68sukdb1	465	5	in	in	IN
cord-295807-68sukdb1	465	6	bacterial	bacterial	JJ
cord-295807-68sukdb1	465	7	vaginosis	vaginosis	NN
cord-295807-68sukdb1	465	8	is	be	VBZ
cord-295807-68sukdb1	465	9	associated	associate	VBN
cord-295807-68sukdb1	465	10	with	with	IN
cord-295807-68sukdb1	465	11	increased	increase	VBN
cord-295807-68sukdb1	465	12	susceptibility	susceptibility	NN
cord-295807-68sukdb1	465	13	to	to	IN
cord-295807-68sukdb1	465	14	STD	std	JJ
cord-295807-68sukdb1	465	15	infection	infection	NN
cord-295807-68sukdb1	465	16	[	[	-LRB-
cord-295807-68sukdb1	465	17	291	291	CD
cord-295807-68sukdb1	465	18	]	]	-RRB-
cord-295807-68sukdb1	465	19	.	.	.
cord-295807-68sukdb1	466	1	With	with	IN
cord-295807-68sukdb1	466	2	regard	regard	NN
cord-295807-68sukdb1	466	3	to	to	IN
cord-295807-68sukdb1	466	4	ultimate	ultimate	JJ
cord-295807-68sukdb1	466	5	reproductive	reproductive	JJ
cord-295807-68sukdb1	466	6	success	success	NN
cord-295807-68sukdb1	466	7	,	,	,
cord-295807-68sukdb1	466	8	maternal	maternal	JJ
cord-295807-68sukdb1	466	9	-	-	HYPH
cord-295807-68sukdb1	466	10	fetal	fetal	JJ
cord-295807-68sukdb1	466	11	acid	acid	NN
cord-295807-68sukdb1	466	12	-	-	HYPH
cord-295807-68sukdb1	466	13	base	base	NN
cord-295807-68sukdb1	466	14	balance	balance	NN
cord-295807-68sukdb1	466	15	is	be	VBZ
cord-295807-68sukdb1	466	16	an	an	DT
cord-295807-68sukdb1	466	17	important	important	JJ
cord-295807-68sukdb1	466	18	determinant	determinant	NN
cord-295807-68sukdb1	466	19	of	of	IN
cord-295807-68sukdb1	466	20	perinatal	perinatal	JJ
cord-295807-68sukdb1	466	21	outcomes	outcome	NNS
cord-295807-68sukdb1	466	22	[	[	-LRB-
cord-295807-68sukdb1	466	23	292	292	CD
cord-295807-68sukdb1	466	24	]	]	-RRB-
cord-295807-68sukdb1	466	25	.	.	.
cord-295807-68sukdb1	467	1	For	for	IN
cord-295807-68sukdb1	467	2	example	example	NN
cord-295807-68sukdb1	467	3	,	,	,
cord-295807-68sukdb1	467	4	obstructed	obstruct	VBN
cord-295807-68sukdb1	467	5	labor	labor	NN
cord-295807-68sukdb1	467	6	has	have	VBZ
cord-295807-68sukdb1	467	7	poor	poor	JJ
cord-295807-68sukdb1	467	8	outcomes	outcome	NNS
cord-295807-68sukdb1	467	9	due	due	JJ
cord-295807-68sukdb1	467	10	to	to	IN
cord-295807-68sukdb1	467	11	intermittent	intermittent	JJ
cord-295807-68sukdb1	467	12	hypoxia	hypoxia	NN
cord-295807-68sukdb1	467	13	and	and	CC
cord-295807-68sukdb1	467	14	lactic	lactic	NN
cord-295807-68sukdb1	467	15	acidosis	acidosis	NN
cord-295807-68sukdb1	467	16	[	[	-LRB-
cord-295807-68sukdb1	467	17	293	293	CD
cord-295807-68sukdb1	467	18	]	]	-RRB-
cord-295807-68sukdb1	467	19	.	.	.
cord-295807-68sukdb1	468	1	Because	because	IN
cord-295807-68sukdb1	468	2	vaginal	vaginal	JJ
cord-295807-68sukdb1	468	3	acidity	acidity	NN
cord-295807-68sukdb1	468	4	tends	tend	VBZ
cord-295807-68sukdb1	468	5	to	to	TO
cord-295807-68sukdb1	468	6	dampen	dampen	VB
cord-295807-68sukdb1	468	7	sperm	sperm	NN
cord-295807-68sukdb1	468	8	motility	motility	NN
cord-295807-68sukdb1	468	9	,	,	,
cord-295807-68sukdb1	468	10	vaginal	vaginal	JJ
cord-295807-68sukdb1	468	11	douching	douching	NN
cord-295807-68sukdb1	468	12	with	with	IN
cord-295807-68sukdb1	468	13	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	468	14	improves	improve	VBZ
cord-295807-68sukdb1	468	15	fertility	fertility	NN
cord-295807-68sukdb1	468	16	[	[	-LRB-
cord-295807-68sukdb1	468	17	294	294	CD
cord-295807-68sukdb1	468	18	,	,	,
cord-295807-68sukdb1	468	19	295	295	CD
cord-295807-68sukdb1	468	20	]	]	-RRB-
cord-295807-68sukdb1	468	21	.	.	.
cord-295807-68sukdb1	469	1	Conversely	conversely	RB
cord-295807-68sukdb1	469	2	,	,	,
cord-295807-68sukdb1	469	3	vaginal	vaginal	JJ
cord-295807-68sukdb1	469	4	acidification	acidification	NN
cord-295807-68sukdb1	469	5	is	be	VBZ
cord-295807-68sukdb1	469	6	contraceptive	contraceptive	JJ
cord-295807-68sukdb1	469	7	and	and	CC
cord-295807-68sukdb1	469	8	prophylactic	prophylactic	JJ
cord-295807-68sukdb1	469	9	.	.	.
cord-295807-68sukdb1	470	1	The	the	DT
cord-295807-68sukdb1	470	2	spermicidal	spermicidal	JJ
cord-295807-68sukdb1	470	3	properties	property	NNS
cord-295807-68sukdb1	470	4	of	of	IN
cord-295807-68sukdb1	470	5	lemon	lemon	NN
cord-295807-68sukdb1	470	6	juice	juice	NN
cord-295807-68sukdb1	470	7	have	have	VBP
cord-295807-68sukdb1	470	8	long	long	RB
cord-295807-68sukdb1	470	9	been	be	VBN
cord-295807-68sukdb1	470	10	appreciated	appreciate	VBN
cord-295807-68sukdb1	470	11	[	[	-LRB-
cord-295807-68sukdb1	470	12	296	296	CD
cord-295807-68sukdb1	470	13	]	]	-RRB-
cord-295807-68sukdb1	470	14	.	.	.
cord-295807-68sukdb1	471	1	Phexxi	Phexxi	NNP
cord-295807-68sukdb1	471	2	™	™	NN
cord-295807-68sukdb1	471	3	(	(	-LRB-
cord-295807-68sukdb1	471	4	formerly	formerly	RB
cord-295807-68sukdb1	471	5	known	know	VBN
cord-295807-68sukdb1	471	6	as	as	IN
cord-295807-68sukdb1	471	7	ACIDFORM	ACIDFORM	NNS
cord-295807-68sukdb1	471	8	:	:	:
cord-295807-68sukdb1	471	9	[	[	-LRB-
cord-295807-68sukdb1	471	10	297	297	CD
cord-295807-68sukdb1	471	11	]	]	-RRB-
cord-295807-68sukdb1	471	12	)	)	-RRB-
cord-295807-68sukdb1	471	13	,	,	,
cord-295807-68sukdb1	471	14	is	be	VBZ
cord-295807-68sukdb1	471	15	the	the	DT
cord-295807-68sukdb1	471	16	most	most	RBS
cord-295807-68sukdb1	471	17	recent	recent	JJ
cord-295807-68sukdb1	471	18	of	of	IN
cord-295807-68sukdb1	471	19	a	a	DT
cord-295807-68sukdb1	471	20	series	series	NN
cord-295807-68sukdb1	471	21	of	of	IN
cord-295807-68sukdb1	471	22	acidic	acidic	JJ
cord-295807-68sukdb1	471	23	contraceptive	contraceptive	JJ
cord-295807-68sukdb1	471	24	gels	gel	NNS
cord-295807-68sukdb1	471	25	.	.	.
cord-295807-68sukdb1	472	1	Phexxi	Phexxi	NNP
cord-295807-68sukdb1	472	2	™	™	NN
cord-295807-68sukdb1	472	3	is	be	VBZ
cord-295807-68sukdb1	472	4	a	a	DT
cord-295807-68sukdb1	472	5	vaginally	vaginally	RB
cord-295807-68sukdb1	472	6	-	-	HYPH
cord-295807-68sukdb1	472	7	applied	apply	VBN
cord-295807-68sukdb1	472	8	gel	gel	NN
cord-295807-68sukdb1	472	9	of	of	IN
cord-295807-68sukdb1	472	10	lactic	lactic	JJ
cord-295807-68sukdb1	472	11	acid	acid	NN
cord-295807-68sukdb1	472	12	,	,	,
cord-295807-68sukdb1	472	13	citric	citric	JJ
cord-295807-68sukdb1	472	14	acid	acid	NN
cord-295807-68sukdb1	472	15	,	,	,
cord-295807-68sukdb1	472	16	and	and	CC
cord-295807-68sukdb1	472	17	potassium	potassium	NN
cord-295807-68sukdb1	472	18	bitartrate	bitartrate	NNP
cord-295807-68sukdb1	472	19	that	that	WDT
cord-295807-68sukdb1	472	20	is	be	VBZ
cord-295807-68sukdb1	472	21	indicated	indicate	VBN
cord-295807-68sukdb1	472	22	by	by	IN
cord-295807-68sukdb1	472	23	the	the	DT
cord-295807-68sukdb1	472	24	FDA	FDA	NNP
cord-295807-68sukdb1	472	25	to	to	TO
cord-295807-68sukdb1	472	26	prevent	prevent	VB
cord-295807-68sukdb1	472	27	pregnancy	pregnancy	NN
cord-295807-68sukdb1	472	28	[	[	-LRB-
cord-295807-68sukdb1	472	29	298	298	CD
cord-295807-68sukdb1	472	30	]	]	-RRB-
cord-295807-68sukdb1	472	31	.	.	.
cord-295807-68sukdb1	473	1	An	an	DT
cord-295807-68sukdb1	473	2	alternate	alternate	JJ
cord-295807-68sukdb1	473	3	approach	approach	NN
cord-295807-68sukdb1	473	4	'	'	``
cord-295807-68sukdb1	473	5	BufferGel	BufferGel	NNP
cord-295807-68sukdb1	473	6	'	'	''
cord-295807-68sukdb1	473	7	utilizes	utilize	VBZ
cord-295807-68sukdb1	473	8	an	an	DT
cord-295807-68sukdb1	473	9	acidic	acidic	JJ
cord-295807-68sukdb1	473	10	polymer	polymer	NN
cord-295807-68sukdb1	473	11	for	for	IN
cord-295807-68sukdb1	473	12	the	the	DT
cord-295807-68sukdb1	473	13	same	same	JJ
cord-295807-68sukdb1	473	14	purpose	purpose	NN
cord-295807-68sukdb1	473	15	[	[	-LRB-
cord-295807-68sukdb1	473	16	291	291	CD
cord-295807-68sukdb1	473	17	]	]	-RRB-
cord-295807-68sukdb1	473	18	.	.	.
cord-295807-68sukdb1	474	1	By	by	IN
cord-295807-68sukdb1	474	2	lowering	lower	VBG
cord-295807-68sukdb1	474	3	vaginal	vaginal	JJ
cord-295807-68sukdb1	474	4	pH	ph	NN
cord-295807-68sukdb1	474	5	these	these	DT
cord-295807-68sukdb1	474	6	products	product	NNS
cord-295807-68sukdb1	474	7	also	also	RB
cord-295807-68sukdb1	474	8	confer	confer	VBP
cord-295807-68sukdb1	474	9	microbicidal	microbicidal	JJ
cord-295807-68sukdb1	474	10	benefits	benefit	NNS
cord-295807-68sukdb1	474	11	[	[	-LRB-
cord-295807-68sukdb1	474	12	291	291	CD
cord-295807-68sukdb1	474	13	]	]	-RRB-
cord-295807-68sukdb1	474	14	.	.	.
cord-295807-68sukdb1	475	1	Finally	finally	RB
cord-295807-68sukdb1	475	2	,	,	,
cord-295807-68sukdb1	475	3	some	some	DT
cord-295807-68sukdb1	475	4	ABT	abt	NN
cord-295807-68sukdb1	475	5	-	-	HYPH
cord-295807-68sukdb1	475	6	targeted	target	VBN
cord-295807-68sukdb1	475	7	drugs	drug	NNS
cord-295807-68sukdb1	475	8	interfere	interfere	VBP
cord-295807-68sukdb1	475	9	with	with	IN
cord-295807-68sukdb1	475	10	fertility	fertility	NN
cord-295807-68sukdb1	475	11	:	:	:
cord-295807-68sukdb1	475	12	CA	CA	NNP
cord-295807-68sukdb1	475	13	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	475	14	,	,	,
cord-295807-68sukdb1	475	15	for	for	IN
cord-295807-68sukdb1	475	16	example	example	NN
cord-295807-68sukdb1	475	17	,	,	,
cord-295807-68sukdb1	475	18	prevent	prevent	VB
cord-295807-68sukdb1	475	19	dispersal	dispersal	NN
cord-295807-68sukdb1	475	20	of	of	IN
cord-295807-68sukdb1	475	21	corona	corona	NN
cord-295807-68sukdb1	475	22	cells	cell	NNS
cord-295807-68sukdb1	475	23	[	[	-LRB-
cord-295807-68sukdb1	475	24	299	299	CD
cord-295807-68sukdb1	475	25	]	]	-RRB-
cord-295807-68sukdb1	475	26	and	and	CC
cord-295807-68sukdb1	475	27	PPIs	ppi	NNS
cord-295807-68sukdb1	475	28	inhibit	inhibit	VBP
cord-295807-68sukdb1	475	29	sperm	sperm	NN
cord-295807-68sukdb1	475	30	motility	motility	NN
cord-295807-68sukdb1	475	31	[	[	-LRB-
cord-295807-68sukdb1	475	32	300	300	CD
cord-295807-68sukdb1	475	33	]	]	-RRB-
cord-295807-68sukdb1	475	34	.	.	.
cord-295807-68sukdb1	476	1	Finally	finally	RB
cord-295807-68sukdb1	476	2	,	,	,
cord-295807-68sukdb1	476	3	with	with	IN
cord-295807-68sukdb1	476	4	regard	regard	NN
cord-295807-68sukdb1	476	5	to	to	IN
cord-295807-68sukdb1	476	6	childbirth	childbirth	NN
cord-295807-68sukdb1	476	7	,	,	,
cord-295807-68sukdb1	476	8	peri	peri	NN
cord-295807-68sukdb1	476	9	-	-	HYPH
cord-295807-68sukdb1	476	10	operative	operative	JJ
cord-295807-68sukdb1	476	11	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	476	12	infusion	infusion	NN
cord-295807-68sukdb1	476	13	has	have	VBZ
cord-295807-68sukdb1	476	14	been	be	VBN
cord-295807-68sukdb1	476	15	proposed	propose	VBN
cord-295807-68sukdb1	476	16	as	as	IN
cord-295807-68sukdb1	476	17	a	a	DT
cord-295807-68sukdb1	476	18	possible	possible	JJ
cord-295807-68sukdb1	476	19	measure	measure	NN
cord-295807-68sukdb1	476	20	to	to	TO
cord-295807-68sukdb1	476	21	improve	improve	VB
cord-295807-68sukdb1	476	22	outcomes	outcome	NNS
cord-295807-68sukdb1	476	23	in	in	IN
cord-295807-68sukdb1	476	24	obstructed	obstruct	VBN
cord-295807-68sukdb1	476	25	labor	labor	NN
cord-295807-68sukdb1	476	26	[	[	-LRB-
cord-295807-68sukdb1	476	27	293	293	CD
cord-295807-68sukdb1	476	28	]	]	-RRB-
cord-295807-68sukdb1	476	29	.	.	.
cord-295807-68sukdb1	477	1	Many	many	JJ
cord-295807-68sukdb1	477	2	metabolic	metabolic	JJ
cord-295807-68sukdb1	477	3	reactions	reaction	NNS
cord-295807-68sukdb1	477	4	that	that	WDT
cord-295807-68sukdb1	477	5	consume	consume	VBP
cord-295807-68sukdb1	477	6	or	or	CC
cord-295807-68sukdb1	477	7	generate	generate	VBP
cord-295807-68sukdb1	477	8	acids	acid	NNS
cord-295807-68sukdb1	477	9	and	and	CC
cord-295807-68sukdb1	477	10	bases	basis	NNS
cord-295807-68sukdb1	477	11	can	can	MD
cord-295807-68sukdb1	477	12	,	,	,
cord-295807-68sukdb1	477	13	in	in	IN
cord-295807-68sukdb1	477	14	disease	disease	NN
cord-295807-68sukdb1	477	15	,	,	,
cord-295807-68sukdb1	477	16	result	result	VB
cord-295807-68sukdb1	477	17	in	in	IN
cord-295807-68sukdb1	477	18	MAc	MAc	NNP
cord-295807-68sukdb1	477	19	.	.	.
cord-295807-68sukdb1	478	1	The	the	DT
cord-295807-68sukdb1	478	2	liver	liver	NN
cord-295807-68sukdb1	478	3	makes	make	VBZ
cord-295807-68sukdb1	478	4	important	important	JJ
cord-295807-68sukdb1	478	5	contributions	contribution	NNS
cord-295807-68sukdb1	478	6	to	to	IN
cord-295807-68sukdb1	478	7	acid	acid	NN
cord-295807-68sukdb1	478	8	-	-	HYPH
cord-295807-68sukdb1	478	9	base	base	NN
cord-295807-68sukdb1	478	10	balance	balance	NN
cord-295807-68sukdb1	478	11	by	by	IN
cord-295807-68sukdb1	478	12	consuming	consume	VBG
cord-295807-68sukdb1	478	13	lactate	lactate	NN
cord-295807-68sukdb1	478	14	(	(	-LRB-
cord-295807-68sukdb1	478	15	countering	counter	VBG
cord-295807-68sukdb1	478	16	lactic	lactic	JJ
cord-295807-68sukdb1	478	17	acidosis	acidosis	NN
cord-295807-68sukdb1	478	18	)	)	-RRB-
cord-295807-68sukdb1	478	19	,	,	,
cord-295807-68sukdb1	478	20	generating	generate	VBG
cord-295807-68sukdb1	478	21	albumin	albumin	NN
cord-295807-68sukdb1	478	22	(	(	-LRB-
cord-295807-68sukdb1	478	23	a	a	DT
cord-295807-68sukdb1	478	24	weak	weak	JJ
cord-295807-68sukdb1	478	25	acid	acid	NN
cord-295807-68sukdb1	478	26	:	:	:
cord-295807-68sukdb1	479	1	hypoalbuminemia	hypoalbuminemia	NNP
cord-295807-68sukdb1	479	2	is	be	VBZ
cord-295807-68sukdb1	479	3	associated	associate	VBN
cord-295807-68sukdb1	479	4	with	with	IN
cord-295807-68sukdb1	479	5	MAlk	MAlk	NNP
cord-295807-68sukdb1	479	6	)	)	-RRB-
cord-295807-68sukdb1	479	7	and	and	CC
cord-295807-68sukdb1	479	8	producing	produce	VBG
cord-295807-68sukdb1	479	9	keto	keto	NNP
cord-295807-68sukdb1	479	10	acids	acid	NNS
cord-295807-68sukdb1	479	11	(	(	-LRB-
cord-295807-68sukdb1	479	12	contributing	contribute	VBG
cord-295807-68sukdb1	479	13	to	to	IN
cord-295807-68sukdb1	479	14	diabetic	diabetic	JJ
cord-295807-68sukdb1	479	15	ketoacidosis	ketoacidosis	NN
cord-295807-68sukdb1	479	16	)	)	-RRB-
cord-295807-68sukdb1	479	17	[	[	-LRB-
cord-295807-68sukdb1	479	18	301	301	CD
cord-295807-68sukdb1	479	19	]	]	-RRB-
cord-295807-68sukdb1	479	20	.	.	.
cord-295807-68sukdb1	480	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	480	2	,	,	,
cord-295807-68sukdb1	480	3	acidbase	acidbase	NN
cord-295807-68sukdb1	480	4	status	status	NN
cord-295807-68sukdb1	480	5	impacts	impact	VBZ
cord-295807-68sukdb1	480	6	the	the	DT
cord-295807-68sukdb1	480	7	activity	activity	NN
cord-295807-68sukdb1	480	8	of	of	IN
cord-295807-68sukdb1	480	9	the	the	DT
cord-295807-68sukdb1	480	10	enzymes	enzyme	NNS
cord-295807-68sukdb1	480	11	that	that	WDT
cord-295807-68sukdb1	480	12	constitute	constitute	VBP
cord-295807-68sukdb1	480	13	several	several	JJ
cord-295807-68sukdb1	480	14	key	key	JJ
cord-295807-68sukdb1	480	15	metabolic	metabolic	JJ
cord-295807-68sukdb1	480	16	pathways	pathway	NNS
cord-295807-68sukdb1	480	17	.	.	.
cord-295807-68sukdb1	481	1	For	for	IN
cord-295807-68sukdb1	481	2	example	example	NN
cord-295807-68sukdb1	481	3	,	,	,
cord-295807-68sukdb1	481	4	acidosis	acidosis	NN
cord-295807-68sukdb1	481	5	inhibits	inhibit	VBZ
cord-295807-68sukdb1	481	6	glycolysis	glycolysis	NN
cord-295807-68sukdb1	481	7	[	[	-LRB-
cord-295807-68sukdb1	481	8	302	302	CD
cord-295807-68sukdb1	481	9	]	]	-RRB-
cord-295807-68sukdb1	481	10	and	and	CC
cord-295807-68sukdb1	481	11	lipolysis	lipolysis	NN
cord-295807-68sukdb1	481	12	[	[	-LRB-
cord-295807-68sukdb1	481	13	303	303	CD
cord-295807-68sukdb1	481	14	]	]	-RRB-
cord-295807-68sukdb1	481	15	but	but	CC
cord-295807-68sukdb1	481	16	stimulates	stimulate	VBZ
cord-295807-68sukdb1	481	17	gluconeogenesis	gluconeogenesis	NN
cord-295807-68sukdb1	481	18	[	[	-LRB-
cord-295807-68sukdb1	481	19	304	304	CD
cord-295807-68sukdb1	481	20	,	,	,
cord-295807-68sukdb1	481	21	305	305	CD
cord-295807-68sukdb1	481	22	]	]	-RRB-
cord-295807-68sukdb1	481	23	.	.	.
cord-295807-68sukdb1	482	1	The	the	DT
cord-295807-68sukdb1	482	2	ability	ability	NN
cord-295807-68sukdb1	482	3	of	of	IN
cord-295807-68sukdb1	482	4	disturbed	disturbed	JJ
cord-295807-68sukdb1	482	5	acid	acid	NN
cord-295807-68sukdb1	482	6	-	-	HYPH
cord-295807-68sukdb1	482	7	base	base	NN
cord-295807-68sukdb1	482	8	balance	balance	NN
cord-295807-68sukdb1	482	9	to	to	TO
cord-295807-68sukdb1	482	10	interfere	interfere	VB
cord-295807-68sukdb1	482	11	with	with	IN
cord-295807-68sukdb1	482	12	glycemic	glycemic	JJ
cord-295807-68sukdb1	482	13	control	control	NN
cord-295807-68sukdb1	482	14	is	be	VBZ
cord-295807-68sukdb1	482	15	further	further	RB
cord-295807-68sukdb1	482	16	evidenced	evidence	VBN
cord-295807-68sukdb1	482	17	by	by	IN
cord-295807-68sukdb1	482	18	the	the	DT
cord-295807-68sukdb1	482	19	following	follow	VBG
cord-295807-68sukdb1	482	20	observations	observation	NNS
cord-295807-68sukdb1	482	21	:	:	:
cord-295807-68sukdb1	482	22	(	(	-LRB-
cord-295807-68sukdb1	482	23	i	i	NN
cord-295807-68sukdb1	482	24	)	)	-RRB-
cord-295807-68sukdb1	482	25	acidosis	acidosis	NN
cord-295807-68sukdb1	482	26	and	and	CC
cord-295807-68sukdb1	482	27	alkalosis	alkalosis	NN
cord-295807-68sukdb1	483	1	both	both	DT
cord-295807-68sukdb1	483	2	lower	low	JJR
cord-295807-68sukdb1	483	3	glucose	glucose	NN
cord-295807-68sukdb1	483	4	-	-	HYPH
cord-295807-68sukdb1	483	5	stimulated	stimulate	VBN
cord-295807-68sukdb1	483	6	insulin	insulin	NN
cord-295807-68sukdb1	483	7	release	release	NN
cord-295807-68sukdb1	483	8	from	from	IN
cord-295807-68sukdb1	483	9	pancreatic	pancreatic	JJ
cord-295807-68sukdb1	483	10	islets	islet	NNS
cord-295807-68sukdb1	483	11	[	[	-LRB-
cord-295807-68sukdb1	483	12	306	306	CD
cord-295807-68sukdb1	483	13	]	]	-RRB-
cord-295807-68sukdb1	483	14	;	;	.
cord-295807-68sukdb1	484	1	(	(	-LRB-
cord-295807-68sukdb1	484	2	ii	ii	NN
cord-295807-68sukdb1	484	3	)	)	-RRB-
cord-295807-68sukdb1	485	1	the	the	DT
cord-295807-68sukdb1	485	2	HCO3content	HCO3content	NNP
cord-295807-68sukdb1	485	3	of	of	IN
cord-295807-68sukdb1	485	4	plasma	plasma	NN
cord-295807-68sukdb1	485	5	correlates	correlate	VBZ
cord-295807-68sukdb1	485	6	with	with	IN
cord-295807-68sukdb1	485	7	insulin	insulin	NN
cord-295807-68sukdb1	485	8	solubility	solubility	NN
cord-295807-68sukdb1	485	9	[	[	-LRB-
cord-295807-68sukdb1	485	10	307	307	CD
cord-295807-68sukdb1	485	11	]	]	-RRB-
cord-295807-68sukdb1	485	12	,	,	.
cord-295807-68sukdb1	486	1	(	(	-LRB-
cord-295807-68sukdb1	486	2	iii	iii	NN
cord-295807-68sukdb1	486	3	)	)	-RRB-
cord-295807-68sukdb1	486	4	acidosis	acidosis	NN
cord-295807-68sukdb1	486	5	is	be	VBZ
cord-295807-68sukdb1	486	6	associated	associate	VBN
cord-295807-68sukdb1	486	7	with	with	IN
cord-295807-68sukdb1	486	8	decreased	decrease	VBN
cord-295807-68sukdb1	486	9	insulin	insulin	NN
cord-295807-68sukdb1	486	10	sensitivity	sensitivity	NN
cord-295807-68sukdb1	486	11	[	[	-LRB-
cord-295807-68sukdb1	486	12	308	308	CD
cord-295807-68sukdb1	486	13	,	,	,
cord-295807-68sukdb1	486	14	309	309	CD
cord-295807-68sukdb1	486	15	]	]	-RRB-
cord-295807-68sukdb1	486	16	.	.	.
cord-295807-68sukdb1	487	1	This	this	DT
cord-295807-68sukdb1	487	2	latter	latter	JJ
cord-295807-68sukdb1	487	3	observation	observation	NN
cord-295807-68sukdb1	487	4	is	be	VBZ
cord-295807-68sukdb1	487	5	due	due	JJ
cord-295807-68sukdb1	487	6	in	in	IN
cord-295807-68sukdb1	487	7	part	part	NN
cord-295807-68sukdb1	487	8	to	to	IN
cord-295807-68sukdb1	487	9	the	the	DT
cord-295807-68sukdb1	487	10	pH	ph	NN
cord-295807-68sukdb1	487	11	-	-	NN
cord-295807-68sukdb1	487	12	sensitivity	sensitivity	NN
cord-295807-68sukdb1	487	13	of	of	IN
cord-295807-68sukdb1	487	14	the	the	DT
cord-295807-68sukdb1	487	15	interaction	interaction	NN
cord-295807-68sukdb1	487	16	between	between	IN
cord-295807-68sukdb1	487	17	insulin	insulin	NN
cord-295807-68sukdb1	487	18	and	and	CC
cord-295807-68sukdb1	487	19	its	-PRON-	PRP$
cord-295807-68sukdb1	487	20	receptor	receptor	NN
cord-295807-68sukdb1	487	21	:	:	:
cord-295807-68sukdb1	487	22	a	a	DT
cord-295807-68sukdb1	487	23	bell	bell	NN
cord-295807-68sukdb1	487	24	-	-	HYPH
cord-295807-68sukdb1	487	25	shaped	shape	VBN
cord-295807-68sukdb1	487	26	pH	ph	NN
cord-295807-68sukdb1	487	27	-	-	NN
cord-295807-68sukdb1	487	28	dependence	dependence	NN
cord-295807-68sukdb1	487	29	that	that	WDT
cord-295807-68sukdb1	487	30	exhibits	exhibit	VBZ
cord-295807-68sukdb1	487	31	strongest	strong	JJS
cord-295807-68sukdb1	487	32	binding	bind	VBG
cord-295807-68sukdb1	487	33	at	at	IN
cord-295807-68sukdb1	487	34	pH	ph	NN
cord-295807-68sukdb1	488	1	~8.0	~8.0	NFP
cord-295807-68sukdb1	488	2	[	[	-LRB-
cord-295807-68sukdb1	488	3	310	310	CD
cord-295807-68sukdb1	488	4	]	]	-RRB-
cord-295807-68sukdb1	488	5	.	.	.
cord-295807-68sukdb1	489	1	In	in	IN
cord-295807-68sukdb1	489	2	fact	fact	NN
cord-295807-68sukdb1	489	3	,	,	,
cord-295807-68sukdb1	489	4	insulin	insulin	NN
cord-295807-68sukdb1	489	5	can	can	MD
cord-295807-68sukdb1	489	6	also	also	RB
cord-295807-68sukdb1	489	7	influence	influence	VB
cord-295807-68sukdb1	489	8	ABT	ABT	NNP
cord-295807-68sukdb1	489	9	action	action	NN
cord-295807-68sukdb1	489	10	.	.	.
cord-295807-68sukdb1	490	1	For	for	IN
cord-295807-68sukdb1	490	2	example	example	NN
cord-295807-68sukdb1	490	3	,	,	,
cord-295807-68sukdb1	490	4	insulin	insulin	NN
cord-295807-68sukdb1	490	5	promotes	promote	VBZ
cord-295807-68sukdb1	490	6	renal	renal	JJ
cord-295807-68sukdb1	490	7	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	490	8	activity	activity	NN
cord-295807-68sukdb1	490	9	.	.	.
cord-295807-68sukdb1	491	1	In	in	IN
cord-295807-68sukdb1	491	2	type	type	NN
cord-295807-68sukdb1	491	3	2	2	CD
cord-295807-68sukdb1	491	4	diabetes	diabetes	NN
cord-295807-68sukdb1	491	5	the	the	DT
cord-295807-68sukdb1	491	6	resulting	result	VBG
cord-295807-68sukdb1	491	7	pathological	pathological	JJ
cord-295807-68sukdb1	491	8	increase	increase	NN
cord-295807-68sukdb1	491	9	in	in	IN
cord-295807-68sukdb1	491	10	renal	renal	JJ
cord-295807-68sukdb1	491	11	fluid	fluid	JJ
cord-295807-68sukdb1	491	12	absorption	absorption	NN
cord-295807-68sukdb1	491	13	caused	cause	VBN
cord-295807-68sukdb1	491	14	by	by	IN
cord-295807-68sukdb1	491	15	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	491	16	upregulation	upregulation	NN
cord-295807-68sukdb1	491	17	is	be	VBZ
cord-295807-68sukdb1	491	18	thought	think	VBN
cord-295807-68sukdb1	491	19	to	to	TO
cord-295807-68sukdb1	491	20	contribute	contribute	VB
cord-295807-68sukdb1	491	21	to	to	IN
cord-295807-68sukdb1	491	22	hypertension	hypertension	NN
cord-295807-68sukdb1	491	23	[	[	-LRB-
cord-295807-68sukdb1	491	24	311	311	CD
cord-295807-68sukdb1	491	25	]	]	-RRB-
cord-295807-68sukdb1	491	26	.	.	.
cord-295807-68sukdb1	492	1	Other	other	JJ
cord-295807-68sukdb1	492	2	hormones	hormone	NNS
cord-295807-68sukdb1	492	3	that	that	WDT
cord-295807-68sukdb1	492	4	influence	influence	VBP
cord-295807-68sukdb1	492	5	acid	acid	NN
cord-295807-68sukdb1	492	6	-	-	HYPH
cord-295807-68sukdb1	492	7	base	base	NN
cord-295807-68sukdb1	492	8	balance	balance	NN
cord-295807-68sukdb1	492	9	include	include	VBP
cord-295807-68sukdb1	492	10	secretin	secretin	NNS
cord-295807-68sukdb1	492	11	(	(	-LRB-
cord-295807-68sukdb1	492	12	increases	increase	NNS
cord-295807-68sukdb1	492	13	pancreatic	pancreatic	NN
cord-295807-68sukdb1	492	14	HCO3secretion	hco3secretion	NN
cord-295807-68sukdb1	492	15	in	in	IN
cord-295807-68sukdb1	492	16	response	response	NN
cord-295807-68sukdb1	492	17	to	to	IN
cord-295807-68sukdb1	492	18	duodenal	duodenal	JJ
cord-295807-68sukdb1	492	19	acidity	acidity	NN
cord-295807-68sukdb1	492	20	[	[	-LRB-
cord-295807-68sukdb1	492	21	312	312	CD
cord-295807-68sukdb1	492	22	]	]	-RRB-
cord-295807-68sukdb1	492	23	)	)	-RRB-
cord-295807-68sukdb1	492	24	,	,	,
cord-295807-68sukdb1	492	25	angiotensin	angiotensin	NN
cord-295807-68sukdb1	492	26	II	II	NNP
cord-295807-68sukdb1	492	27	and	and	CC
cord-295807-68sukdb1	492	28	aldosterone	aldosterone	NN
cord-295807-68sukdb1	492	29	(	(	-LRB-
cord-295807-68sukdb1	492	30	increases	increase	VBZ
cord-295807-68sukdb1	492	31	renal	renal	JJ
cord-295807-68sukdb1	492	32	acid	acid	NN
cord-295807-68sukdb1	492	33	excretion	excretion	NN
cord-295807-68sukdb1	492	34	in	in	IN
cord-295807-68sukdb1	492	35	acidosis	acidosis	NN
cord-295807-68sukdb1	492	36	[	[	-LRB-
cord-295807-68sukdb1	492	37	84	84	CD
cord-295807-68sukdb1	492	38	,	,	,
cord-295807-68sukdb1	492	39	313	313	CD
cord-295807-68sukdb1	492	40	]	]	-RRB-
cord-295807-68sukdb1	492	41	)	)	-RRB-
cord-295807-68sukdb1	492	42	,	,	,
cord-295807-68sukdb1	492	43	and	and	CC
cord-295807-68sukdb1	492	44	parathyroid	parathyroid	JJ
cord-295807-68sukdb1	492	45	hormone	hormone	NN
cord-295807-68sukdb1	492	46	(	(	-LRB-
cord-295807-68sukdb1	492	47	increases	increase	NNS
cord-295807-68sukdb1	492	48	renal	renal	JJ
cord-295807-68sukdb1	492	49	acid	acid	NN
cord-295807-68sukdb1	492	50	excretion	excretion	NN
cord-295807-68sukdb1	492	51	and	and	CC
cord-295807-68sukdb1	492	52	excretion	excretion	NN
cord-295807-68sukdb1	492	53	of	of	IN
cord-295807-68sukdb1	492	54	urinary	urinary	JJ
cord-295807-68sukdb1	492	55	-	-	HYPH
cord-295807-68sukdb1	492	56	buffer	buffer	NN
cord-295807-68sukdb1	492	57	phosphate	phosphate	NN
cord-295807-68sukdb1	492	58	in	in	IN
cord-295807-68sukdb1	492	59	acidosis	acidosis	NN
cord-295807-68sukdb1	492	60	:	:	:
cord-295807-68sukdb1	492	61	[	[	-LRB-
cord-295807-68sukdb1	492	62	212	212	CD
cord-295807-68sukdb1	492	63	]	]	-RRB-
cord-295807-68sukdb1	492	64	)	)	-RRB-
cord-295807-68sukdb1	492	65	.	.	.
cord-295807-68sukdb1	493	1	Interestingly	interestingly	RB
cord-295807-68sukdb1	493	2	,	,	,
cord-295807-68sukdb1	493	3	licorice	licorice	NN
cord-295807-68sukdb1	493	4	can	can	MD
cord-295807-68sukdb1	493	5	cause	cause	VB
cord-295807-68sukdb1	493	6	MAlk	MAlk	NNP
cord-295807-68sukdb1	493	7	because	because	IN
cord-295807-68sukdb1	493	8	one	one	CD
cord-295807-68sukdb1	493	9	of	of	IN
cord-295807-68sukdb1	493	10	its	-PRON-	PRP$
cord-295807-68sukdb1	493	11	constituent	constituent	NN
cord-295807-68sukdb1	493	12	compounds	compound	NNS
cord-295807-68sukdb1	493	13	(	(	-LRB-
cord-295807-68sukdb1	493	14	glycyrrhizic	glycyrrhizic	NNP
cord-295807-68sukdb1	493	15	acid	acid	NNP
cord-295807-68sukdb1	493	16	)	)	-RRB-
cord-295807-68sukdb1	493	17	indirectly	indirectly	RB
cord-295807-68sukdb1	493	18	causes	cause	VBZ
cord-295807-68sukdb1	493	19	overstimulation	overstimulation	NN
cord-295807-68sukdb1	493	20	of	of	IN
cord-295807-68sukdb1	493	21	the	the	DT
cord-295807-68sukdb1	493	22	aldosterone	aldosterone	NN
cord-295807-68sukdb1	493	23	receptor	receptor	NN
cord-295807-68sukdb1	493	24	[	[	-LRB-
cord-295807-68sukdb1	493	25	314	314	CD
cord-295807-68sukdb1	493	26	]	]	-RRB-
cord-295807-68sukdb1	493	27	.	.	.
cord-295807-68sukdb1	494	1	Hormones	hormone	NNS
cord-295807-68sukdb1	494	2	whose	whose	WP$
cord-295807-68sukdb1	494	3	levels	level	NNS
cord-295807-68sukdb1	494	4	are	be	VBP
cord-295807-68sukdb1	494	5	pathologically	pathologically	RB
cord-295807-68sukdb1	494	6	altered	alter	VBN
cord-295807-68sukdb1	494	7	in	in	IN
cord-295807-68sukdb1	494	8	acidosis	acidosis	NN
cord-295807-68sukdb1	494	9	include	include	VBP
cord-295807-68sukdb1	494	10	aldosterone	aldosterone	NN
cord-295807-68sukdb1	494	11	and	and	CC
cord-295807-68sukdb1	494	12	endothelin	endothelin	NNP
cord-295807-68sukdb1	494	13	(	(	-LRB-
cord-295807-68sukdb1	494	14	increased	increase	VBN
cord-295807-68sukdb1	494	15	:	:	:
cord-295807-68sukdb1	494	16	[	[	-LRB-
cord-295807-68sukdb1	494	17	315	315	CD
cord-295807-68sukdb1	494	18	,	,	,
cord-295807-68sukdb1	494	19	316	316	CD
cord-295807-68sukdb1	494	20	]	]	-RRB-
cord-295807-68sukdb1	494	21	)	)	-RRB-
cord-295807-68sukdb1	494	22	cortisone	cortisone	NN
cord-295807-68sukdb1	494	23	(	(	-LRB-
cord-295807-68sukdb1	494	24	increased	increase	VBN
cord-295807-68sukdb1	494	25	:	:	:
cord-295807-68sukdb1	494	26	[	[	-LRB-
cord-295807-68sukdb1	494	27	317	317	CD
cord-295807-68sukdb1	494	28	]	]	-RRB-
cord-295807-68sukdb1	494	29	)	)	-RRB-
cord-295807-68sukdb1	494	30	,	,	,
cord-295807-68sukdb1	494	31	and	and	CC
cord-295807-68sukdb1	494	32	IGF-1	IGF-1	NNP
cord-295807-68sukdb1	494	33	(	(	-LRB-
cord-295807-68sukdb1	494	34	decreased	decrease	VBD
cord-295807-68sukdb1	494	35	:	:	:
cord-295807-68sukdb1	494	36	[	[	-LRB-
cord-295807-68sukdb1	494	37	318	318	CD
cord-295807-68sukdb1	494	38	]	]	-RRB-
cord-295807-68sukdb1	494	39	)	)	-RRB-
cord-295807-68sukdb1	494	40	.	.	.
cord-295807-68sukdb1	495	1	Metabolic	metabolic	JJ
cord-295807-68sukdb1	495	2	reprogramming	reprogramming	NN
cord-295807-68sukdb1	495	3	of	of	IN
cord-295807-68sukdb1	495	4	cancer	cancer	NN
cord-295807-68sukdb1	495	5	cells	cell	NNS
cord-295807-68sukdb1	495	6	in	in	IN
cord-295807-68sukdb1	495	7	the	the	DT
cord-295807-68sukdb1	495	8	hypoxic	hypoxic	JJ
cord-295807-68sukdb1	495	9	and	and	CC
cord-295807-68sukdb1	495	10	acidotic	acidotic	JJ
cord-295807-68sukdb1	495	11	tumor	tumor	NN
cord-295807-68sukdb1	495	12	environment	environment	NN
cord-295807-68sukdb1	495	13	is	be	VBZ
cord-295807-68sukdb1	495	14	discussed	discuss	VBN
cord-295807-68sukdb1	495	15	further	further	RB
cord-295807-68sukdb1	495	16	in	in	IN
cord-295807-68sukdb1	495	17	a	a	DT
cord-295807-68sukdb1	495	18	later	later	JJ
cord-295807-68sukdb1	495	19	section	section	NN
cord-295807-68sukdb1	495	20	(	(	-LRB-
cord-295807-68sukdb1	495	21	see	see	VB
cord-295807-68sukdb1	495	22	5.6	5.6	CD
cord-295807-68sukdb1	495	23	Oncology	Oncology	NNP
cord-295807-68sukdb1	495	24	.	.	.
cord-295807-68sukdb1	495	25	)	)	-RRB-
cord-295807-68sukdb1	496	1	The	the	DT
cord-295807-68sukdb1	496	2	influence	influence	NN
cord-295807-68sukdb1	496	3	and	and	CC
cord-295807-68sukdb1	496	4	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	496	5	relevance	relevance	NN
cord-295807-68sukdb1	496	6	of	of	IN
cord-295807-68sukdb1	496	7	pH	ph	NN
cord-295807-68sukdb1	496	8	upon	upon	IN
cord-295807-68sukdb1	496	9	endocrine	endocrine	JJ
cord-295807-68sukdb1	496	10	and	and	CC
cord-295807-68sukdb1	496	11	metabolic	metabolic	JJ
cord-295807-68sukdb1	496	12	aspects	aspect	NNS
cord-295807-68sukdb1	496	13	of	of	IN
cord-295807-68sukdb1	496	14	heart	heart	NN
cord-295807-68sukdb1	496	15	function	function	NN
cord-295807-68sukdb1	496	16	,	,	,
cord-295807-68sukdb1	496	17	muscle	muscle	NN
cord-295807-68sukdb1	496	18	mass	mass	NN
cord-295807-68sukdb1	496	19	,	,	,
cord-295807-68sukdb1	496	20	and	and	CC
cord-295807-68sukdb1	496	21	bone	bone	NN
cord-295807-68sukdb1	496	22	growth	growth	NN
cord-295807-68sukdb1	496	23	have	have	VBP
cord-295807-68sukdb1	496	24	been	be	VBN
cord-295807-68sukdb1	496	25	discussed	discuss	VBN
cord-295807-68sukdb1	496	26	in	in	IN
cord-295807-68sukdb1	496	27	earlier	early	JJR
cord-295807-68sukdb1	496	28	sections	section	NNS
cord-295807-68sukdb1	496	29	(	(	-LRB-
cord-295807-68sukdb1	496	30	4.4	4.4	CD
cord-295807-68sukdb1	496	31	,	,	,
cord-295807-68sukdb1	496	32	4.5	4.5	CD
cord-295807-68sukdb1	496	33	,	,	,
cord-295807-68sukdb1	496	34	and	and	CC
cord-295807-68sukdb1	496	35	4.6	4.6	CD
cord-295807-68sukdb1	496	36	)	)	-RRB-
cord-295807-68sukdb1	496	37	.	.	.
cord-295807-68sukdb1	497	1	The	the	DT
cord-295807-68sukdb1	497	2	link	link	NN
cord-295807-68sukdb1	497	3	between	between	IN
cord-295807-68sukdb1	497	4	dietary	dietary	JJ
cord-295807-68sukdb1	497	5	acid	acid	NN
cord-295807-68sukdb1	497	6	load	load	NN
cord-295807-68sukdb1	497	7	and	and	CC
cord-295807-68sukdb1	497	8	development	development	NN
cord-295807-68sukdb1	497	9	of	of	IN
cord-295807-68sukdb1	497	10	insulin	insulin	NN
cord-295807-68sukdb1	497	11	sensitivity	sensitivity	NN
cord-295807-68sukdb1	497	12	has	have	VBZ
cord-295807-68sukdb1	497	13	made	make	VBN
cord-295807-68sukdb1	497	14	dietary	dietary	JJ
cord-295807-68sukdb1	497	15	control	control	NN
cord-295807-68sukdb1	497	16	an	an	DT
cord-295807-68sukdb1	497	17	appealing	appealing	JJ
cord-295807-68sukdb1	497	18	target	target	NN
cord-295807-68sukdb1	497	19	for	for	IN
cord-295807-68sukdb1	497	20	lowering	lower	VBG
cord-295807-68sukdb1	497	21	the	the	DT
cord-295807-68sukdb1	497	22	incidence	incidence	NN
cord-295807-68sukdb1	497	23	of	of	IN
cord-295807-68sukdb1	497	24	type	type	NN
cord-295807-68sukdb1	497	25	2	2	CD
cord-295807-68sukdb1	497	26	diabetes	diabete	NNS
cord-295807-68sukdb1	497	27	,	,	,
cord-295807-68sukdb1	497	28	although	although	IN
cord-295807-68sukdb1	497	29	overwhelming	overwhelming	JJ
cord-295807-68sukdb1	497	30	evidence	evidence	NN
cord-295807-68sukdb1	497	31	of	of	IN
cord-295807-68sukdb1	497	32	efficacy	efficacy	NN
cord-295807-68sukdb1	497	33	is	be	VBZ
cord-295807-68sukdb1	497	34	currently	currently	RB
cord-295807-68sukdb1	497	35	lacking	lack	VBG
cord-295807-68sukdb1	497	36	[	[	-LRB-
cord-295807-68sukdb1	497	37	308	308	CD
cord-295807-68sukdb1	497	38	]	]	-RRB-
cord-295807-68sukdb1	497	39	.	.	.
cord-295807-68sukdb1	498	1	Because	because	IN
cord-295807-68sukdb1	498	2	of	of	IN
cord-295807-68sukdb1	498	3	the	the	DT
cord-295807-68sukdb1	498	4	pH	ph	NN
cord-295807-68sukdb1	498	5	-	-	NN
cord-295807-68sukdb1	498	6	dependence	dependence	NN
cord-295807-68sukdb1	498	7	of	of	IN
cord-295807-68sukdb1	498	8	insulin	insulin	NN
cord-295807-68sukdb1	498	9	solubility	solubility	NN
cord-295807-68sukdb1	498	10	,	,	,
cord-295807-68sukdb1	498	11	the	the	DT
cord-295807-68sukdb1	498	12	dissolution	dissolution	NN
cord-295807-68sukdb1	498	13	time	time	NN
cord-295807-68sukdb1	498	14	of	of	IN
cord-295807-68sukdb1	498	15	administered	administer	VBN
cord-295807-68sukdb1	498	16	insulin	insulin	NN
cord-295807-68sukdb1	498	17	is	be	VBZ
cord-295807-68sukdb1	498	18	slower	slow	JJR
cord-295807-68sukdb1	498	19	in	in	IN
cord-295807-68sukdb1	498	20	plasma	plasma	NN
cord-295807-68sukdb1	498	21	from	from	IN
cord-295807-68sukdb1	498	22	diabetics	diabetic	NNS
cord-295807-68sukdb1	498	23	with	with	IN
cord-295807-68sukdb1	498	24	DKA	DKA	NNP
cord-295807-68sukdb1	498	25	than	than	IN
cord-295807-68sukdb1	498	26	in	in	IN
cord-295807-68sukdb1	498	27	otherwise	otherwise	RB
cord-295807-68sukdb1	498	28	normal	normal	JJ
cord-295807-68sukdb1	498	29	plasma	plasma	NN
cord-295807-68sukdb1	498	30	,	,	,
cord-295807-68sukdb1	498	31	suggesting	suggest	VBG
cord-295807-68sukdb1	498	32	at	at	IN
cord-295807-68sukdb1	498	33	face	face	NN
cord-295807-68sukdb1	498	34	value	value	NN
cord-295807-68sukdb1	498	35	that	that	WDT
cord-295807-68sukdb1	498	36	combined	combine	VBD
cord-295807-68sukdb1	498	37	insulin	insulin	NN
cord-295807-68sukdb1	498	38	-	-	HYPH
cord-295807-68sukdb1	498	39	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	498	40	therapy	therapy	NN
cord-295807-68sukdb1	498	41	might	may	MD
cord-295807-68sukdb1	498	42	be	be	VB
cord-295807-68sukdb1	498	43	valuable	valuable	JJ
cord-295807-68sukdb1	498	44	[	[	-LRB-
cord-295807-68sukdb1	498	45	319	319	CD
cord-295807-68sukdb1	498	46	]	]	-RRB-
cord-295807-68sukdb1	498	47	.	.	.
cord-295807-68sukdb1	499	1	However	however	RB
cord-295807-68sukdb1	499	2	,	,	,
cord-295807-68sukdb1	499	3	such	such	JJ
cord-295807-68sukdb1	499	4	treatment	treatment	NN
cord-295807-68sukdb1	499	5	in	in	IN
cord-295807-68sukdb1	499	6	practice	practice	NN
cord-295807-68sukdb1	499	7	may	may	MD
cord-295807-68sukdb1	499	8	be	be	VB
cord-295807-68sukdb1	499	9	of	of	IN
cord-295807-68sukdb1	499	10	limited	limited	JJ
cord-295807-68sukdb1	499	11	value	value	NN
cord-295807-68sukdb1	499	12	and	and	CC
cord-295807-68sukdb1	499	13	has	have	VBZ
cord-295807-68sukdb1	499	14	been	be	VBN
cord-295807-68sukdb1	499	15	linked	link	VBN
cord-295807-68sukdb1	499	16	to	to	IN
cord-295807-68sukdb1	499	17	development	development	NN
cord-295807-68sukdb1	499	18	of	of	IN
cord-295807-68sukdb1	499	19	cerebral	cerebral	JJ
cord-295807-68sukdb1	499	20	edema	edema	NN
cord-295807-68sukdb1	499	21	in	in	IN
cord-295807-68sukdb1	499	22	children	child	NNS
cord-295807-68sukdb1	499	23	[	[	-LRB-
cord-295807-68sukdb1	499	24	320	320	CD
cord-295807-68sukdb1	499	25	]	]	-RRB-
cord-295807-68sukdb1	499	26	.	.	.
cord-295807-68sukdb1	500	1	The	the	DT
cord-295807-68sukdb1	500	2	influence	influence	NN
cord-295807-68sukdb1	500	3	of	of	IN
cord-295807-68sukdb1	500	4	pH	ph	NN
cord-295807-68sukdb1	500	5	on	on	IN
cord-295807-68sukdb1	500	6	drug	drug	NN
cord-295807-68sukdb1	500	7	solubility	solubility	NN
cord-295807-68sukdb1	500	8	is	be	VBZ
cord-295807-68sukdb1	500	9	discussed	discuss	VBN
cord-295807-68sukdb1	500	10	in	in	IN
cord-295807-68sukdb1	500	11	more	more	JJR
cord-295807-68sukdb1	500	12	detail	detail	NN
cord-295807-68sukdb1	500	13	in	in	IN
cord-295807-68sukdb1	500	14	section	section	NN
cord-295807-68sukdb1	500	15	6.2	6.2	CD
cord-295807-68sukdb1	500	16	.	.	.
cord-295807-68sukdb1	501	1	pH	pH	NNP
cord-295807-68sukdb1	501	2	plays	play	VBZ
cord-295807-68sukdb1	501	3	a	a	DT
cord-295807-68sukdb1	501	4	role	role	NN
cord-295807-68sukdb1	501	5	in	in	IN
cord-295807-68sukdb1	501	6	all	all	DT
cord-295807-68sukdb1	501	7	aspects	aspect	NNS
cord-295807-68sukdb1	501	8	of	of	IN
cord-295807-68sukdb1	501	9	the	the	DT
cord-295807-68sukdb1	501	10	immune	immune	JJ
cord-295807-68sukdb1	501	11	response	response	NN
cord-295807-68sukdb1	501	12	.	.	.
cord-295807-68sukdb1	502	1	First	first	RB
cord-295807-68sukdb1	502	2	we	-PRON-	PRP
cord-295807-68sukdb1	502	3	will	will	MD
cord-295807-68sukdb1	502	4	enumerate	enumerate	VB
cord-295807-68sukdb1	502	5	the	the	DT
cord-295807-68sukdb1	502	6	subcellular	subcellular	JJ
cord-295807-68sukdb1	502	7	effects	effect	NNS
cord-295807-68sukdb1	502	8	:	:	:
cord-295807-68sukdb1	503	1	(	(	-LRB-
cord-295807-68sukdb1	503	2	i	i	NN
cord-295807-68sukdb1	503	3	)	)	-RRB-
cord-295807-68sukdb1	504	1	The	the	DT
cord-295807-68sukdb1	504	2	cytosolic	cytosolic	JJ
cord-295807-68sukdb1	504	3	alkalinization	alkalinization	NN
cord-295807-68sukdb1	504	4	that	that	WDT
cord-295807-68sukdb1	504	5	promotes	promote	VBZ
cord-295807-68sukdb1	504	6	cytoskeletal	cytoskeletal	JJ
cord-295807-68sukdb1	504	7	rearrangement	rearrangement	NN
cord-295807-68sukdb1	504	8	during	during	IN
cord-295807-68sukdb1	504	9	neutrophil	neutrophil	NN
cord-295807-68sukdb1	504	10	spreading	spreading	NN
cord-295807-68sukdb1	504	11	(	(	-LRB-
cord-295807-68sukdb1	504	12	the	the	DT
cord-295807-68sukdb1	504	13	morphological	morphological	JJ
cord-295807-68sukdb1	504	14	change	change	NN
cord-295807-68sukdb1	504	15	that	that	WDT
cord-295807-68sukdb1	504	16	is	be	VBZ
cord-295807-68sukdb1	504	17	important	important	JJ
cord-295807-68sukdb1	504	18	for	for	IN
cord-295807-68sukdb1	504	19	capillary	capillary	JJ
cord-295807-68sukdb1	504	20	adhesion	adhesion	NN
cord-295807-68sukdb1	504	21	and	and	CC
cord-295807-68sukdb1	504	22	extravasation	extravasation	NN
cord-295807-68sukdb1	504	23	)	)	-RRB-
cord-295807-68sukdb1	504	24	requires	require	VBZ
cord-295807-68sukdb1	504	25	NHE1	NHE1	NNP
cord-295807-68sukdb1	504	26	action	action	NN
cord-295807-68sukdb1	504	27	[	[	-LRB-
cord-295807-68sukdb1	504	28	321	321	CD
cord-295807-68sukdb1	504	29	]	]	-RRB-
cord-295807-68sukdb1	504	30	.	.	.
cord-295807-68sukdb1	505	1	(	(	-LRB-
cord-295807-68sukdb1	505	2	ii	ii	NN
cord-295807-68sukdb1	505	3	)	)	-RRB-
cord-295807-68sukdb1	506	1	Inflammatory	inflammatory	JJ
cord-295807-68sukdb1	506	2	sites	site	NNS
cord-295807-68sukdb1	506	3	are	be	VBP
cord-295807-68sukdb1	506	4	usually	usually	RB
cord-295807-68sukdb1	506	5	acidic	acidic	JJ
cord-295807-68sukdb1	506	6	due	due	IN
cord-295807-68sukdb1	506	7	to	to	IN
cord-295807-68sukdb1	506	8	the	the	DT
cord-295807-68sukdb1	506	9	metabolic	metabolic	JJ
cord-295807-68sukdb1	506	10	activities	activity	NNS
cord-295807-68sukdb1	506	11	of	of	IN
cord-295807-68sukdb1	506	12	invading	invade	VBG
cord-295807-68sukdb1	506	13	bacteria	bacteria	NNS
cord-295807-68sukdb1	506	14	and	and	CC
cord-295807-68sukdb1	506	15	neutrophils	neutrophil	NNS
cord-295807-68sukdb1	506	16	,	,	,
cord-295807-68sukdb1	506	17	an	an	DT
cord-295807-68sukdb1	506	18	environment	environment	NN
cord-295807-68sukdb1	506	19	that	that	WDT
cord-295807-68sukdb1	506	20	promotes	promote	VBZ
cord-295807-68sukdb1	506	21	the	the	DT
cord-295807-68sukdb1	506	22	production	production	NN
cord-295807-68sukdb1	506	23	of	of	IN
cord-295807-68sukdb1	506	24	proinflammatory	proinflammatory	JJ
cord-295807-68sukdb1	506	25	cytokines	cytokine	NNS
cord-295807-68sukdb1	506	26	[	[	-LRB-
cord-295807-68sukdb1	506	27	322	322	CD
cord-295807-68sukdb1	506	28	]	]	-RRB-
cord-295807-68sukdb1	506	29	(	(	-LRB-
cord-295807-68sukdb1	506	30	see	see	VB
cord-295807-68sukdb1	506	31	also	also	RB
cord-295807-68sukdb1	506	32	section	section	NN
cord-295807-68sukdb1	506	33	4.3	4.3	CD
cord-295807-68sukdb1	506	34	)	)	-RRB-
cord-295807-68sukdb1	506	35	.	.	.
cord-295807-68sukdb1	507	1	(	(	-LRB-
cord-295807-68sukdb1	507	2	iii	iii	NN
cord-295807-68sukdb1	507	3	)	)	-RRB-
cord-295807-68sukdb1	508	1	During	during	IN
cord-295807-68sukdb1	508	2	bacterial	bacterial	JJ
cord-295807-68sukdb1	508	3	killing	killing	NN
cord-295807-68sukdb1	508	4	,	,	,
cord-295807-68sukdb1	508	5	H	h	NN
cord-295807-68sukdb1	508	6	+	+	CC
cord-295807-68sukdb1	508	7	efflux	efflux	NN
cord-295807-68sukdb1	508	8	into	into	IN
cord-295807-68sukdb1	508	9	the	the	DT
cord-295807-68sukdb1	508	10	phagosome	phagosome	NN
cord-295807-68sukdb1	508	11	is	be	VBZ
cord-295807-68sukdb1	508	12	necessary	necessary	JJ
cord-295807-68sukdb1	508	13	for	for	IN
cord-295807-68sukdb1	508	14	charge	charge	NN
cord-295807-68sukdb1	508	15	compensation	compensation	NN
cord-295807-68sukdb1	508	16	during	during	IN
cord-295807-68sukdb1	508	17	the	the	DT
cord-295807-68sukdb1	508	18	respiratory	respiratory	JJ
cord-295807-68sukdb1	508	19	burst	burst	NN
cord-295807-68sukdb1	508	20	that	that	WDT
cord-295807-68sukdb1	508	21	produces	produce	VBZ
cord-295807-68sukdb1	508	22	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	508	23	superoxide	superoxide	NN
cord-295807-68sukdb1	508	24	anions	anion	NNS
cord-295807-68sukdb1	508	25	.	.	.
cord-295807-68sukdb1	509	1	This	this	DT
cord-295807-68sukdb1	509	2	action	action	NN
cord-295807-68sukdb1	509	3	is	be	VBZ
cord-295807-68sukdb1	509	4	mediated	mediate	VBN
cord-295807-68sukdb1	509	5	by	by	IN
cord-295807-68sukdb1	509	6	the	the	DT
cord-295807-68sukdb1	509	7	voltage	voltage	NN
cord-295807-68sukdb1	509	8	-	-	HYPH
cord-295807-68sukdb1	509	9	gated	gate	VBN
cord-295807-68sukdb1	509	10	H	h	NN
cord-295807-68sukdb1	509	11	+	+	CC
cord-295807-68sukdb1	509	12	channel	channel	NN
cord-295807-68sukdb1	509	13	HV1	HV1	NNP
cord-295807-68sukdb1	509	14	[	[	-LRB-
cord-295807-68sukdb1	509	15	323	323	NNP
cord-295807-68sukdb1	509	16	]	]	-RRB-
cord-295807-68sukdb1	509	17	.	.	.
cord-295807-68sukdb1	510	1	(	(	-LRB-
cord-295807-68sukdb1	510	2	iv	iv	LS
cord-295807-68sukdb1	510	3	)	)	-RRB-
cord-295807-68sukdb1	510	4	Some	some	DT
cord-295807-68sukdb1	510	5	of	of	IN
cord-295807-68sukdb1	510	6	the	the	DT
cord-295807-68sukdb1	510	7	generated	generate	VBN
cord-295807-68sukdb1	510	8	superoxide	superoxide	NN
cord-295807-68sukdb1	510	9	is	be	VBZ
cord-295807-68sukdb1	510	10	converted	convert	VBN
cord-295807-68sukdb1	510	11	into	into	IN
cord-295807-68sukdb1	510	12	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	510	13	hypochlorous	hypochlorous	JJ
cord-295807-68sukdb1	510	14	acid	acid	NN
cord-295807-68sukdb1	510	15	(	(	-LRB-
cord-295807-68sukdb1	510	16	HOCl	HOCl	NNP
cord-295807-68sukdb1	510	17	)	)	-RRB-
cord-295807-68sukdb1	510	18	which	which	WDT
cord-295807-68sukdb1	510	19	is	be	VBZ
cord-295807-68sukdb1	510	20	able	able	JJ
cord-295807-68sukdb1	510	21	to	to	TO
cord-295807-68sukdb1	510	22	diffuse	diffuse	VB
cord-295807-68sukdb1	510	23	back	back	RB
cord-295807-68sukdb1	510	24	into	into	IN
cord-295807-68sukdb1	510	25	the	the	DT
cord-295807-68sukdb1	510	26	neutrophil	neutrophil	NN
cord-295807-68sukdb1	510	27	cytoplasm	cytoplasm	NN
cord-295807-68sukdb1	510	28	.	.	.
cord-295807-68sukdb1	511	1	Thus	thus	RB
cord-295807-68sukdb1	511	2	the	the	DT
cord-295807-68sukdb1	511	3	action	action	NN
cord-295807-68sukdb1	511	4	of	of	IN
cord-295807-68sukdb1	511	5	phagosomal	phagosomal	NNP
cord-295807-68sukdb1	511	6	HV1	HV1	NNP
cord-295807-68sukdb1	511	7	,	,	,
cord-295807-68sukdb1	511	8	together	together	RB
cord-295807-68sukdb1	511	9	with	with	IN
cord-295807-68sukdb1	511	10	the	the	DT
cord-295807-68sukdb1	511	11	action	action	NN
cord-295807-68sukdb1	511	12	of	of	IN
cord-295807-68sukdb1	511	13	NHE1	NHE1	NNP
cord-295807-68sukdb1	511	14	in	in	IN
cord-295807-68sukdb1	511	15	the	the	DT
cord-295807-68sukdb1	511	16	plasma	plasma	NN
cord-295807-68sukdb1	511	17	membrane	membrane	NN
cord-295807-68sukdb1	511	18	,	,	,
cord-295807-68sukdb1	511	19	defends	defend	VBZ
cord-295807-68sukdb1	511	20	the	the	DT
cord-295807-68sukdb1	511	21	neutrophil	neutrophil	NN
cord-295807-68sukdb1	511	22	cytoplasm	cytoplasm	NN
cord-295807-68sukdb1	511	23	from	from	IN
cord-295807-68sukdb1	511	24	acidosis	acidosis	NN
cord-295807-68sukdb1	511	25	which	which	WDT
cord-295807-68sukdb1	511	26	would	would	MD
cord-295807-68sukdb1	511	27	otherwise	otherwise	RB
cord-295807-68sukdb1	511	28	dampen	dampen	VB
cord-295807-68sukdb1	511	29	NADPH	NADPH	NNP
cord-295807-68sukdb1	511	30	oxidase	oxidase	NN
cord-295807-68sukdb1	511	31	activity	activity	NN
cord-295807-68sukdb1	511	32	[	[	-LRB-
cord-295807-68sukdb1	511	33	321	321	CD
cord-295807-68sukdb1	511	34	,	,	,
cord-295807-68sukdb1	511	35	324	324	CD
cord-295807-68sukdb1	511	36	,	,	,
cord-295807-68sukdb1	511	37	325	325	CD
cord-295807-68sukdb1	511	38	]	]	-RRB-
cord-295807-68sukdb1	511	39	.	.	.
cord-295807-68sukdb1	512	1	Secondly	secondly	RB
cord-295807-68sukdb1	512	2	we	-PRON-	PRP
cord-295807-68sukdb1	512	3	can	can	MD
cord-295807-68sukdb1	512	4	consider	consider	VB
cord-295807-68sukdb1	512	5	the	the	DT
cord-295807-68sukdb1	512	6	effect	effect	NN
cord-295807-68sukdb1	512	7	of	of	IN
cord-295807-68sukdb1	512	8	acid	acid	NN
cord-295807-68sukdb1	512	9	-	-	HYPH
cord-295807-68sukdb1	512	10	base	base	NN
cord-295807-68sukdb1	512	11	disturbance	disturbance	NN
cord-295807-68sukdb1	512	12	on	on	IN
cord-295807-68sukdb1	512	13	the	the	DT
cord-295807-68sukdb1	512	14	whole	whole	JJ
cord-295807-68sukdb1	512	15	cell	cell	NN
cord-295807-68sukdb1	512	16	.	.	.
cord-295807-68sukdb1	513	1	Although	although	IN
cord-295807-68sukdb1	513	2	the	the	DT
cord-295807-68sukdb1	513	3	pH	pH	NNP
cord-295807-68sukdb1	513	4	sensitivity	sensitivity	NN
cord-295807-68sukdb1	513	5	of	of	IN
cord-295807-68sukdb1	513	6	individual	individual	JJ
cord-295807-68sukdb1	513	7	immune	immune	JJ
cord-295807-68sukdb1	513	8	cell	cell	NN
cord-295807-68sukdb1	513	9	types	type	NNS
cord-295807-68sukdb1	513	10	are	be	VBP
cord-295807-68sukdb1	513	11	well	well	RB
cord-295807-68sukdb1	513	12	characterized	characterize	VBN
cord-295807-68sukdb1	513	13	in	in	IN
cord-295807-68sukdb1	513	14	vitro	vitro	FW
cord-295807-68sukdb1	513	15	(	(	-LRB-
cord-295807-68sukdb1	513	16	e.g.	e.g.	RB
cord-295807-68sukdb1	513	17	,	,	,
cord-295807-68sukdb1	513	18	acidosis	acidosis	NN
cord-295807-68sukdb1	513	19	decreases	decrease	VBZ
cord-295807-68sukdb1	513	20	leukocyte	leukocyte	NN
cord-295807-68sukdb1	513	21	and	and	CC
cord-295807-68sukdb1	513	22	neutrophil	neutrophil	NN
cord-295807-68sukdb1	513	23	mobility	mobility	NN
cord-295807-68sukdb1	513	24	[	[	-LRB-
cord-295807-68sukdb1	513	25	326	326	CD
cord-295807-68sukdb1	513	26	]	]	-RRB-
cord-295807-68sukdb1	513	27	,	,	,
cord-295807-68sukdb1	513	28	promotes	promote	VBZ
cord-295807-68sukdb1	513	29	complement	complement	JJ
cord-295807-68sukdb1	513	30	activation	activation	NN
cord-295807-68sukdb1	513	31	[	[	-LRB-
cord-295807-68sukdb1	513	32	327	327	CD
cord-295807-68sukdb1	513	33	]	]	-RRB-
cord-295807-68sukdb1	513	34	,	,	,
cord-295807-68sukdb1	513	35	modulates	modulate	VBZ
cord-295807-68sukdb1	513	36	expression	expression	NN
cord-295807-68sukdb1	513	37	of	of	IN
cord-295807-68sukdb1	513	38	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	513	39	mediators	mediator	NNS
cord-295807-68sukdb1	513	40	[	[	-LRB-
cord-295807-68sukdb1	513	41	326	326	CD
cord-295807-68sukdb1	513	42	]	]	-RRB-
cord-295807-68sukdb1	513	43	)	)	-RRB-
cord-295807-68sukdb1	513	44	,	,	,
cord-295807-68sukdb1	513	45	there	there	EX
cord-295807-68sukdb1	513	46	are	be	VBP
cord-295807-68sukdb1	513	47	many	many	JJ
cord-295807-68sukdb1	513	48	subtleties	subtlety	NNS
cord-295807-68sukdb1	513	49	to	to	IN
cord-295807-68sukdb1	513	50	these	these	DT
cord-295807-68sukdb1	513	51	effects	effect	NNS
cord-295807-68sukdb1	513	52	.	.	.
cord-295807-68sukdb1	514	1	For	for	IN
cord-295807-68sukdb1	514	2	example	example	NN
cord-295807-68sukdb1	514	3	the	the	DT
cord-295807-68sukdb1	514	4	type	type	NN
cord-295807-68sukdb1	514	5	of	of	IN
cord-295807-68sukdb1	514	6	acidosis	acidosis	NN
cord-295807-68sukdb1	514	7	,	,	,
cord-295807-68sukdb1	514	8	type	type	NN
cord-295807-68sukdb1	514	9	of	of	IN
cord-295807-68sukdb1	514	10	cell	cell	NN
cord-295807-68sukdb1	514	11	,	,	,
cord-295807-68sukdb1	514	12	activation	activation	NN
cord-295807-68sukdb1	514	13	state	state	NN
cord-295807-68sukdb1	514	14	of	of	IN
cord-295807-68sukdb1	514	15	the	the	DT
cord-295807-68sukdb1	514	16	cell	cell	NN
cord-295807-68sukdb1	514	17	,	,	,
cord-295807-68sukdb1	514	18	and	and	CC
cord-295807-68sukdb1	514	19	effects	effect	NNS
cord-295807-68sukdb1	514	20	on	on	IN
cord-295807-68sukdb1	514	21	phagocytic	phagocytic	JJ
cord-295807-68sukdb1	514	22	activity	activity	NN
cord-295807-68sukdb1	514	23	versus	versus	IN
cord-295807-68sukdb1	514	24	migration	migration	NN
cord-295807-68sukdb1	514	25	may	may	MD
cord-295807-68sukdb1	514	26	all	all	DT
cord-295807-68sukdb1	514	27	influence	influence	VB
cord-295807-68sukdb1	514	28	the	the	DT
cord-295807-68sukdb1	514	29	effect	effect	NN
cord-295807-68sukdb1	514	30	of	of	IN
cord-295807-68sukdb1	514	31	acid	acid	NN
cord-295807-68sukdb1	514	32	-	-	HYPH
cord-295807-68sukdb1	514	33	base	base	NN
cord-295807-68sukdb1	514	34	disturbance	disturbance	NN
cord-295807-68sukdb1	514	35	on	on	IN
cord-295807-68sukdb1	514	36	the	the	DT
cord-295807-68sukdb1	514	37	immune	immune	JJ
cord-295807-68sukdb1	514	38	response	response	NN
cord-295807-68sukdb1	514	39	mediated	mediate	VBN
cord-295807-68sukdb1	514	40	by	by	IN
cord-295807-68sukdb1	514	41	a	a	DT
cord-295807-68sukdb1	514	42	given	give	VBN
cord-295807-68sukdb1	514	43	cell	cell	NN
cord-295807-68sukdb1	514	44	type	type	NN
cord-295807-68sukdb1	514	45	[	[	-LRB-
cord-295807-68sukdb1	514	46	328	328	CD
cord-295807-68sukdb1	514	47	]	]	-RRB-
cord-295807-68sukdb1	514	48	.	.	.
cord-295807-68sukdb1	515	1	Thus	thus	RB
cord-295807-68sukdb1	515	2	,	,	,
cord-295807-68sukdb1	515	3	for	for	IN
cord-295807-68sukdb1	515	4	example	example	NN
cord-295807-68sukdb1	515	5	,	,	,
cord-295807-68sukdb1	515	6	acidosis	acidosis	NN
cord-295807-68sukdb1	515	7	enhances	enhance	VBZ
cord-295807-68sukdb1	515	8	bacterial	bacterial	JJ
cord-295807-68sukdb1	515	9	killing	killing	NN
cord-295807-68sukdb1	515	10	by	by	IN
cord-295807-68sukdb1	515	11	neutrophils	neutrophil	NNS
cord-295807-68sukdb1	515	12	[	[	-LRB-
cord-295807-68sukdb1	515	13	329	329	CD
cord-295807-68sukdb1	515	14	]	]	-RRB-
cord-295807-68sukdb1	515	15	and	and	CC
cord-295807-68sukdb1	515	16	leukocytes	leukocyte	NNS
cord-295807-68sukdb1	515	17	[	[	-LRB-
cord-295807-68sukdb1	515	18	330	330	CD
cord-295807-68sukdb1	515	19	]	]	-RRB-
cord-295807-68sukdb1	515	20	but	but	CC
cord-295807-68sukdb1	515	21	not	not	RB
cord-295807-68sukdb1	515	22	by	by	IN
cord-295807-68sukdb1	515	23	macrophages	macrophage	NNS
cord-295807-68sukdb1	515	24	[	[	-LRB-
cord-295807-68sukdb1	515	25	331	331	CD
cord-295807-68sukdb1	515	26	]	]	-RRB-
cord-295807-68sukdb1	515	27	.	.	.
cord-295807-68sukdb1	516	1	Although	although	IN
cord-295807-68sukdb1	516	2	it	-PRON-	PRP
cord-295807-68sukdb1	516	3	is	be	VBZ
cord-295807-68sukdb1	516	4	complicated	complicated	JJ
cord-295807-68sukdb1	516	5	to	to	TO
cord-295807-68sukdb1	516	6	tease	tease	VB
cord-295807-68sukdb1	516	7	out	out	RP
cord-295807-68sukdb1	516	8	a	a	DT
cord-295807-68sukdb1	516	9	set	set	NN
cord-295807-68sukdb1	516	10	of	of	IN
cord-295807-68sukdb1	516	11	concerted	concerted	JJ
cord-295807-68sukdb1	516	12	mechanisms	mechanism	NNS
cord-295807-68sukdb1	516	13	,	,	,
cord-295807-68sukdb1	516	14	in	in	IN
cord-295807-68sukdb1	516	15	general	general	JJ
cord-295807-68sukdb1	516	16	,	,	,
cord-295807-68sukdb1	516	17	systemic	systemic	JJ
cord-295807-68sukdb1	516	18	acidosis	acidosis	NN
cord-295807-68sukdb1	516	19	is	be	VBZ
cord-295807-68sukdb1	516	20	associated	associate	VBN
cord-295807-68sukdb1	516	21	with	with	IN
cord-295807-68sukdb1	516	22	compromised	compromised	JJ
cord-295807-68sukdb1	516	23	immune	immune	JJ
cord-295807-68sukdb1	516	24	function	function	NN
cord-295807-68sukdb1	516	25	[	[	-LRB-
cord-295807-68sukdb1	516	26	328	328	CD
cord-295807-68sukdb1	516	27	,	,	,
cord-295807-68sukdb1	516	28	332	332	CD
cord-295807-68sukdb1	516	29	]	]	-RRB-
cord-295807-68sukdb1	516	30	.	.	.
cord-295807-68sukdb1	517	1	[	[	-LRB-
cord-295807-68sukdb1	517	2	333	333	CD
cord-295807-68sukdb1	517	3	]	]	-RRB-
cord-295807-68sukdb1	517	4	.	.	.
cord-295807-68sukdb1	518	1	The	the	DT
cord-295807-68sukdb1	518	2	link	link	NN
cord-295807-68sukdb1	518	3	between	between	IN
cord-295807-68sukdb1	518	4	pH	ph	NN
cord-295807-68sukdb1	518	5	and	and	CC
cord-295807-68sukdb1	518	6	disturbed	disturbed	JJ
cord-295807-68sukdb1	518	7	immune	immune	JJ
cord-295807-68sukdb1	518	8	response	response	NN
cord-295807-68sukdb1	518	9	is	be	VBZ
cord-295807-68sukdb1	518	10	demonstrated	demonstrate	VBN
cord-295807-68sukdb1	518	11	by	by	IN
cord-295807-68sukdb1	518	12	the	the	DT
cord-295807-68sukdb1	518	13	following	follow	VBG
cord-295807-68sukdb1	518	14	example	example	NN
cord-295807-68sukdb1	518	15	.	.	.
cord-295807-68sukdb1	519	1	Single	single	JJ
cord-295807-68sukdb1	519	2	nucleotide	nucleotide	JJ
cord-295807-68sukdb1	519	3	polymorphisms	polymorphism	NNS
cord-295807-68sukdb1	519	4	in	in	IN
cord-295807-68sukdb1	519	5	the	the	DT
cord-295807-68sukdb1	519	6	acid	acid	NN
cord-295807-68sukdb1	519	7	-	-	HYPH
cord-295807-68sukdb1	519	8	loading	load	VBG
cord-295807-68sukdb1	519	9	protein	protein	NN
cord-295807-68sukdb1	519	10	AE2	AE2	NNS
cord-295807-68sukdb1	519	11	are	be	VBP
cord-295807-68sukdb1	519	12	linked	link	VBN
cord-295807-68sukdb1	519	13	to	to	IN
cord-295807-68sukdb1	519	14	progression	progression	NN
cord-295807-68sukdb1	519	15	of	of	IN
cord-295807-68sukdb1	519	16	primary	primary	JJ
cord-295807-68sukdb1	519	17	biliary	biliary	JJ
cord-295807-68sukdb1	519	18	cholangitis	cholangitis	NN
cord-295807-68sukdb1	519	19	.	.	.
cord-295807-68sukdb1	520	1	A	a	DT
cord-295807-68sukdb1	520	2	mechanism	mechanism	NN
cord-295807-68sukdb1	520	3	is	be	VBZ
cord-295807-68sukdb1	520	4	suggested	suggest	VBN
cord-295807-68sukdb1	520	5	by	by	IN
cord-295807-68sukdb1	520	6	studies	study	NNS
cord-295807-68sukdb1	520	7	of	of	IN
cord-295807-68sukdb1	520	8	Ae2-null	Ae2-null	NNP
cord-295807-68sukdb1	520	9	mice	mouse	NNS
cord-295807-68sukdb1	520	10	in	in	IN
cord-295807-68sukdb1	520	11	which	which	WDT
cord-295807-68sukdb1	520	12	loss	loss	NN
cord-295807-68sukdb1	520	13	of	of	IN
cord-295807-68sukdb1	520	14	Ae2	ae2	CD
cord-295807-68sukdb1	520	15	from	from	IN
cord-295807-68sukdb1	520	16	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	520	17	T	t	NN
cord-295807-68sukdb1	520	18	-	-	HYPH
cord-295807-68sukdb1	520	19	cells	cell	NNS
cord-295807-68sukdb1	520	20	causes	cause	VBZ
cord-295807-68sukdb1	520	21	a	a	DT
cord-295807-68sukdb1	520	22	pHi	phi	JJ
cord-295807-68sukdb1	520	23	increase	increase	NN
cord-295807-68sukdb1	520	24	that	that	WDT
cord-295807-68sukdb1	520	25	promotes	promote	VBZ
cord-295807-68sukdb1	520	26	their	-PRON-	PRP$
cord-295807-68sukdb1	520	27	proliferation	proliferation	NN
cord-295807-68sukdb1	520	28	,	,	,
cord-295807-68sukdb1	520	29	activation	activation	NN
cord-295807-68sukdb1	520	30	and	and	CC
cord-295807-68sukdb1	520	31	survival	survival	NN
cord-295807-68sukdb1	520	32	,	,	,
cord-295807-68sukdb1	520	33	amplifying	amplify	VBG
cord-295807-68sukdb1	520	34	the	the	DT
cord-295807-68sukdb1	520	35	autoimmune	autoimmune	JJ
cord-295807-68sukdb1	520	36	response	response	NN
cord-295807-68sukdb1	520	37	against	against	IN
cord-295807-68sukdb1	520	38	damaged	damage	VBN
cord-295807-68sukdb1	520	39	liver	liver	NN
cord-295807-68sukdb1	520	40	cells	cell	NNS
cord-295807-68sukdb1	520	41	.	.	.
cord-295807-68sukdb1	521	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	521	2	,	,	,
cord-295807-68sukdb1	521	3	type	type	NN
cord-295807-68sukdb1	521	4	IV	IV	NNP
cord-295807-68sukdb1	521	5	dRTA	dRTA	NNP
cord-295807-68sukdb1	521	6	is	be	VBZ
cord-295807-68sukdb1	521	7	linked	link	VBN
cord-295807-68sukdb1	521	8	to	to	IN
cord-295807-68sukdb1	521	9	systemic	systemic	JJ
cord-295807-68sukdb1	521	10	lupus	lupus	NN
cord-295807-68sukdb1	521	11	erythematosus	erythematosus	NN
cord-295807-68sukdb1	521	12	,	,	,
cord-295807-68sukdb1	521	13	although	although	IN
cord-295807-68sukdb1	521	14	the	the	DT
cord-295807-68sukdb1	521	15	causal	causal	JJ
cord-295807-68sukdb1	521	16	relationship	relationship	NN
cord-295807-68sukdb1	521	17	is	be	VBZ
cord-295807-68sukdb1	521	18	unclear	unclear	JJ
cord-295807-68sukdb1	521	19	[	[	-LRB-
cord-295807-68sukdb1	521	20	334	334	CD
cord-295807-68sukdb1	521	21	,	,	,
cord-295807-68sukdb1	521	22	335	335	CD
cord-295807-68sukdb1	521	23	]	]	-RRB-
cord-295807-68sukdb1	521	24	.	.	.
cord-295807-68sukdb1	522	1	Several	several	JJ
cord-295807-68sukdb1	522	2	paradigms	paradigm	NNS
cord-295807-68sukdb1	522	3	have	have	VBP
cord-295807-68sukdb1	522	4	been	be	VBN
cord-295807-68sukdb1	522	5	proposed	propose	VBN
cord-295807-68sukdb1	522	6	to	to	TO
cord-295807-68sukdb1	522	7	suppress	suppress	VB
cord-295807-68sukdb1	522	8	a	a	DT
cord-295807-68sukdb1	522	9	pathological	pathological	JJ
cord-295807-68sukdb1	522	10	immune	immune	JJ
cord-295807-68sukdb1	522	11	response	response	NN
cord-295807-68sukdb1	522	12	.	.	.
cord-295807-68sukdb1	523	1	Oral	oral	JJ
cord-295807-68sukdb1	523	2	NaHCO3	nahco3	CD
cord-295807-68sukdb1	523	3	dosing	dose	VBG
cord-295807-68sukdb1	523	4	in	in	IN
cord-295807-68sukdb1	523	5	rats	rat	NNS
cord-295807-68sukdb1	523	6	stimulates	stimulate	VBZ
cord-295807-68sukdb1	523	7	an	an	DT
cord-295807-68sukdb1	523	8	anti	anti	JJ
cord-295807-68sukdb1	523	9	-	-	JJ
cord-295807-68sukdb1	523	10	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	523	11	response	response	NN
cord-295807-68sukdb1	523	12	;	;	:
cord-295807-68sukdb1	523	13	this	this	DT
cord-295807-68sukdb1	523	14	effect	effect	NN
cord-295807-68sukdb1	523	15	could	could	MD
cord-295807-68sukdb1	523	16	be	be	VB
cord-295807-68sukdb1	523	17	harnessed	harness	VBN
cord-295807-68sukdb1	523	18	to	to	TO
cord-295807-68sukdb1	523	19	prevent	prevent	VB
cord-295807-68sukdb1	523	20	tissue	tissue	NN
cord-295807-68sukdb1	523	21	damage	damage	NN
cord-295807-68sukdb1	523	22	in	in	IN
cord-295807-68sukdb1	523	23	autoimmune	autoimmune	JJ
cord-295807-68sukdb1	523	24	diseases	disease	NNS
cord-295807-68sukdb1	523	25	such	such	JJ
cord-295807-68sukdb1	523	26	as	as	IN
cord-295807-68sukdb1	523	27	rheumatoid	rheumatoid	NN
cord-295807-68sukdb1	523	28	arthritis	arthritis	NN
cord-295807-68sukdb1	523	29	[	[	-LRB-
cord-295807-68sukdb1	523	30	336	336	CD
cord-295807-68sukdb1	523	31	]	]	-RRB-
cord-295807-68sukdb1	523	32	.	.	.
cord-295807-68sukdb1	524	1	One	one	CD
cord-295807-68sukdb1	524	2	preliminary	preliminary	JJ
cord-295807-68sukdb1	524	3	study	study	NN
cord-295807-68sukdb1	524	4	in	in	IN
cord-295807-68sukdb1	524	5	mice	mouse	NNS
cord-295807-68sukdb1	524	6	even	even	RB
cord-295807-68sukdb1	524	7	suggests	suggest	VBZ
cord-295807-68sukdb1	524	8	that	that	IN
cord-295807-68sukdb1	524	9	oral	oral	JJ
cord-295807-68sukdb1	524	10	NaHCO3	nahco3	NN
cord-295807-68sukdb1	524	11	dosing	dosing	NN
cord-295807-68sukdb1	524	12	could	could	MD
cord-295807-68sukdb1	524	13	be	be	VB
cord-295807-68sukdb1	524	14	useful	useful	JJ
cord-295807-68sukdb1	524	15	to	to	TO
cord-295807-68sukdb1	524	16	suppress	suppress	VB
cord-295807-68sukdb1	524	17	peanut	peanut	NN
cord-295807-68sukdb1	524	18	allergy	allergy	NN
cord-295807-68sukdb1	524	19	[	[	-LRB-
cord-295807-68sukdb1	524	20	337	337	CD
cord-295807-68sukdb1	524	21	]	]	-RRB-
cord-295807-68sukdb1	524	22	.	.	.
cord-295807-68sukdb1	525	1	Regarding	regard	VBG
cord-295807-68sukdb1	525	2	the	the	DT
cord-295807-68sukdb1	525	3	pharmacological	pharmacological	JJ
cord-295807-68sukdb1	525	4	aspect	aspect	NN
cord-295807-68sukdb1	525	5	,	,	,
cord-295807-68sukdb1	525	6	MCT1	MCT1	NNP
cord-295807-68sukdb1	525	7	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	525	8	act	act	VBP
cord-295807-68sukdb1	525	9	as	as	IN
cord-295807-68sukdb1	525	10	immunosuppressors	immunosuppressor	NNS
cord-295807-68sukdb1	525	11	by	by	IN
cord-295807-68sukdb1	525	12	interfering	interfere	VBG
cord-295807-68sukdb1	525	13	with	with	IN
cord-295807-68sukdb1	525	14	the	the	DT
cord-295807-68sukdb1	525	15	disposal	disposal	NN
cord-295807-68sukdb1	525	16	of	of	IN
cord-295807-68sukdb1	525	17	lactate	lactate	NN
cord-295807-68sukdb1	525	18	during	during	IN
cord-295807-68sukdb1	525	19	T	t	NN
cord-295807-68sukdb1	525	20	-	-	HYPH
cord-295807-68sukdb1	525	21	cell	cell	NN
cord-295807-68sukdb1	525	22	activation	activation	NN
cord-295807-68sukdb1	525	23	[	[	-LRB-
cord-295807-68sukdb1	525	24	338	338	CD
cord-295807-68sukdb1	525	25	]	]	-RRB-
cord-295807-68sukdb1	525	26	.	.	.
cord-295807-68sukdb1	526	1	Finally	finally	RB
cord-295807-68sukdb1	526	2	,	,	,
cord-295807-68sukdb1	526	3	the	the	DT
cord-295807-68sukdb1	526	4	NHE1	NHE1	NNP
cord-295807-68sukdb1	526	5	blocker	blocker	NN
cord-295807-68sukdb1	526	6	cariporide	cariporide	NN
cord-295807-68sukdb1	526	7	suppresses	suppress	VBZ
cord-295807-68sukdb1	526	8	the	the	DT
cord-295807-68sukdb1	526	9	systemic	systemic	JJ
cord-295807-68sukdb1	526	10	immune	immune	JJ
cord-295807-68sukdb1	526	11	response	response	NN
cord-295807-68sukdb1	526	12	to	to	TO
cord-295807-68sukdb1	526	13	burn	burn	VB
cord-295807-68sukdb1	526	14	injury	injury	NN
cord-295807-68sukdb1	526	15	in	in	IN
cord-295807-68sukdb1	526	16	rats	rat	NNS
cord-295807-68sukdb1	526	17	,	,	,
cord-295807-68sukdb1	526	18	although	although	IN
cord-295807-68sukdb1	526	19	the	the	DT
cord-295807-68sukdb1	526	20	mechanism	mechanism	NN
cord-295807-68sukdb1	526	21	is	be	VBZ
cord-295807-68sukdb1	526	22	unclear	unclear	JJ
cord-295807-68sukdb1	526	23	[	[	-LRB-
cord-295807-68sukdb1	526	24	339	339	CD
cord-295807-68sukdb1	526	25	]	]	-RRB-
cord-295807-68sukdb1	526	26	.	.	.
cord-295807-68sukdb1	527	1	On	on	IN
cord-295807-68sukdb1	527	2	the	the	DT
cord-295807-68sukdb1	527	3	other	other	JJ
cord-295807-68sukdb1	527	4	hand	hand	NN
cord-295807-68sukdb1	527	5	,	,	,
cord-295807-68sukdb1	527	6	knowledge	knowledge	NN
cord-295807-68sukdb1	527	7	of	of	IN
cord-295807-68sukdb1	527	8	acid	acid	NN
cord-295807-68sukdb1	527	9	-	-	HYPH
cord-295807-68sukdb1	527	10	base	base	NN
cord-295807-68sukdb1	527	11	balance	balance	NN
cord-295807-68sukdb1	527	12	can	can	MD
cord-295807-68sukdb1	527	13	be	be	VB
cord-295807-68sukdb1	527	14	exploited	exploit	VBN
cord-295807-68sukdb1	527	15	to	to	TO
cord-295807-68sukdb1	527	16	promote	promote	VB
cord-295807-68sukdb1	527	17	an	an	DT
cord-295807-68sukdb1	527	18	immune	immune	JJ
cord-295807-68sukdb1	527	19	response	response	NN
cord-295807-68sukdb1	527	20	.	.	.
cord-295807-68sukdb1	528	1	It	-PRON-	PRP
cord-295807-68sukdb1	528	2	has	have	VBZ
cord-295807-68sukdb1	528	3	been	be	VBN
cord-295807-68sukdb1	528	4	suggested	suggest	VBN
cord-295807-68sukdb1	528	5	that	that	IN
cord-295807-68sukdb1	528	6	blocking	block	VBG
cord-295807-68sukdb1	528	7	AE2	AE2	NNP
cord-295807-68sukdb1	528	8	to	to	TO
cord-295807-68sukdb1	528	9	promote	promote	VB
cord-295807-68sukdb1	528	10	a	a	DT
cord-295807-68sukdb1	528	11	stronger	strong	JJR
cord-295807-68sukdb1	528	12	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	528	13	T	t	NN
cord-295807-68sukdb1	528	14	-	-	HYPH
cord-295807-68sukdb1	528	15	cell	cell	NN
cord-295807-68sukdb1	528	16	response	response	NN
cord-295807-68sukdb1	528	17	could	could	MD
cord-295807-68sukdb1	528	18	be	be	VB
cord-295807-68sukdb1	528	19	useful	useful	JJ
cord-295807-68sukdb1	528	20	for	for	IN
cord-295807-68sukdb1	528	21	treatment	treatment	NN
cord-295807-68sukdb1	528	22	of	of	IN
cord-295807-68sukdb1	528	23	chronic	chronic	JJ
cord-295807-68sukdb1	528	24	infections	infection	NNS
cord-295807-68sukdb1	528	25	[	[	-LRB-
cord-295807-68sukdb1	528	26	333	333	CD
cord-295807-68sukdb1	528	27	]	]	-RRB-
cord-295807-68sukdb1	528	28	.	.	.
cord-295807-68sukdb1	529	1	Considerations	consideration	NNS
cord-295807-68sukdb1	529	2	about	about	IN
cord-295807-68sukdb1	529	3	the	the	DT
cord-295807-68sukdb1	529	4	role	role	NN
cord-295807-68sukdb1	529	5	of	of	IN
cord-295807-68sukdb1	529	6	pH	ph	NN
cord-295807-68sukdb1	529	7	in	in	IN
cord-295807-68sukdb1	529	8	cancer	cancer	NN
cord-295807-68sukdb1	529	9	immunotherapy	immunotherapy	NN
cord-295807-68sukdb1	529	10	are	be	VBP
cord-295807-68sukdb1	529	11	included	include	VBN
cord-295807-68sukdb1	529	12	in	in	IN
cord-295807-68sukdb1	529	13	section	section	NN
cord-295807-68sukdb1	529	14	5.6	5.6	CD
cord-295807-68sukdb1	529	15	.	.	.
cord-295807-68sukdb1	530	1	Neuronal	neuronal	JJ
cord-295807-68sukdb1	530	2	activity	activity	NN
cord-295807-68sukdb1	530	3	is	be	VBZ
cord-295807-68sukdb1	530	4	pH	pH	NNP
cord-295807-68sukdb1	530	5	dependent	dependent	JJ
cord-295807-68sukdb1	530	6	(	(	-LRB-
cord-295807-68sukdb1	530	7	see	see	VB
cord-295807-68sukdb1	530	8	section	section	NN
cord-295807-68sukdb1	530	9	4.1	4.1	CD
cord-295807-68sukdb1	530	10	)	)	-RRB-
cord-295807-68sukdb1	530	11	and	and	CC
cord-295807-68sukdb1	530	12	there	there	EX
cord-295807-68sukdb1	530	13	is	be	VBZ
cord-295807-68sukdb1	530	14	emerging	emerge	VBG
cord-295807-68sukdb1	530	15	evidence	evidence	NN
cord-295807-68sukdb1	530	16	that	that	IN
cord-295807-68sukdb1	530	17	agents	agent	NNS
cord-295807-68sukdb1	530	18	of	of	IN
cord-295807-68sukdb1	530	19	acid	acid	NN
cord-295807-68sukdb1	530	20	-	-	HYPH
cord-295807-68sukdb1	530	21	base	base	NN
cord-295807-68sukdb1	530	22	balance	balance	NN
cord-295807-68sukdb1	530	23	can	can	MD
cord-295807-68sukdb1	530	24	influence	influence	VB
cord-295807-68sukdb1	530	25	behavior	behavior	NN
cord-295807-68sukdb1	530	26	and	and	CC
cord-295807-68sukdb1	530	27	progression	progression	NN
cord-295807-68sukdb1	530	28	of	of	IN
cord-295807-68sukdb1	530	29	neuropsychiatric	neuropsychiatric	JJ
cord-295807-68sukdb1	530	30	disorders	disorder	NNS
cord-295807-68sukdb1	530	31	.	.	.
cord-295807-68sukdb1	531	1	Inhalation	inhalation	NN
cord-295807-68sukdb1	531	2	of	of	IN
cord-295807-68sukdb1	531	3	CO2	CO2	NNP
cord-295807-68sukdb1	531	4	(	(	-LRB-
cord-295807-68sukdb1	531	5	despite	despite	IN
cord-295807-68sukdb1	531	6	its	-PRON-	PRP$
cord-295807-68sukdb1	531	7	general	general	JJ
cord-295807-68sukdb1	531	8	dampening	dampen	VBG
cord-295807-68sukdb1	531	9	action	action	NN
cord-295807-68sukdb1	531	10	on	on	IN
cord-295807-68sukdb1	531	11	neuronal	neuronal	JJ
cord-295807-68sukdb1	531	12	excitability	excitability	NN
cord-295807-68sukdb1	531	13	,	,	,
cord-295807-68sukdb1	531	14	see	see	VB
cord-295807-68sukdb1	531	15	section	section	NN
cord-295807-68sukdb1	531	16	4.1.2	4.1.2	CD
cord-295807-68sukdb1	531	17	)	)	-RRB-
cord-295807-68sukdb1	531	18	invokes	invoke	VBZ
cord-295807-68sukdb1	531	19	anxiety	anxiety	NN
cord-295807-68sukdb1	531	20	and	and	CC
cord-295807-68sukdb1	531	21	panic	panic	NN
cord-295807-68sukdb1	531	22	,	,	,
cord-295807-68sukdb1	531	23	and	and	CC
cord-295807-68sukdb1	531	24	the	the	DT
cord-295807-68sukdb1	531	25	influence	influence	NN
cord-295807-68sukdb1	531	26	of	of	IN
cord-295807-68sukdb1	531	27	CO2	CO2	NNP
cord-295807-68sukdb1	531	28	is	be	VBZ
cord-295807-68sukdb1	531	29	exacerbated	exacerbate	VBN
cord-295807-68sukdb1	531	30	in	in	IN
cord-295807-68sukdb1	531	31	individuals	individual	NNS
cord-295807-68sukdb1	531	32	with	with	IN
cord-295807-68sukdb1	531	33	panic	panic	NN
cord-295807-68sukdb1	531	34	disorders	disorder	NNS
cord-295807-68sukdb1	531	35	[	[	-LRB-
cord-295807-68sukdb1	531	36	340	340	CD
cord-295807-68sukdb1	531	37	]	]	-RRB-
cord-295807-68sukdb1	531	38	.	.	.
cord-295807-68sukdb1	532	1	Studies	study	NNS
cord-295807-68sukdb1	532	2	in	in	IN
cord-295807-68sukdb1	532	3	mice	mouse	NNS
cord-295807-68sukdb1	532	4	indicate	indicate	VBP
cord-295807-68sukdb1	532	5	that	that	IN
cord-295807-68sukdb1	532	6	lowering	lower	VBG
cord-295807-68sukdb1	532	7	brain	brain	NN
cord-295807-68sukdb1	532	8	pH	pH	NNP
cord-295807-68sukdb1	532	9	triggers	trigger	VBZ
cord-295807-68sukdb1	532	10	the	the	DT
cord-295807-68sukdb1	532	11	action	action	NN
cord-295807-68sukdb1	532	12	of	of	IN
cord-295807-68sukdb1	532	13	the	the	DT
cord-295807-68sukdb1	532	14	acidsensing	acidsensing	NNP
cord-295807-68sukdb1	532	15	ion	ion	NN
cord-295807-68sukdb1	532	16	channel	channel	NN
cord-295807-68sukdb1	532	17	ASIC1a	asic1a	NN
cord-295807-68sukdb1	532	18	in	in	IN
cord-295807-68sukdb1	532	19	the	the	DT
cord-295807-68sukdb1	532	20	regions	region	NNS
cord-295807-68sukdb1	532	21	of	of	IN
cord-295807-68sukdb1	532	22	the	the	DT
cord-295807-68sukdb1	532	23	brain	brain	NN
cord-295807-68sukdb1	532	24	responsible	responsible	JJ
cord-295807-68sukdb1	532	25	for	for	IN
cord-295807-68sukdb1	532	26	stress	stress	NN
cord-295807-68sukdb1	532	27	,	,	,
cord-295807-68sukdb1	532	28	fear	fear	NN
cord-295807-68sukdb1	532	29	,	,	,
cord-295807-68sukdb1	532	30	and	and	CC
cord-295807-68sukdb1	532	31	social	social	JJ
cord-295807-68sukdb1	532	32	behavior	behavior	NN
cord-295807-68sukdb1	532	33	[	[	-LRB-
cord-295807-68sukdb1	532	34	341	341	CD
cord-295807-68sukdb1	532	35	,	,	,
cord-295807-68sukdb1	532	36	342	342	CD
cord-295807-68sukdb1	532	37	]	]	-RRB-
cord-295807-68sukdb1	532	38	.	.	.
cord-295807-68sukdb1	533	1	The	the	DT
cord-295807-68sukdb1	533	2	acquisition	acquisition	NN
cord-295807-68sukdb1	533	3	of	of	IN
cord-295807-68sukdb1	533	4	fear	fear	NN
cord-295807-68sukdb1	533	5	-	-	HYPH
cord-295807-68sukdb1	533	6	related	relate	VBN
cord-295807-68sukdb1	533	7	freezing	freezing	JJ
cord-295807-68sukdb1	533	8	behavior	behavior	NN
cord-295807-68sukdb1	533	9	in	in	IN
cord-295807-68sukdb1	533	10	mice	mouse	NNS
cord-295807-68sukdb1	533	11	is	be	VBZ
cord-295807-68sukdb1	533	12	enhanced	enhance	VBN
cord-295807-68sukdb1	533	13	by	by	IN
cord-295807-68sukdb1	533	14	ASIC1a	ASIC1a	NNP
cord-295807-68sukdb1	533	15	overexpression	overexpression	NN
cord-295807-68sukdb1	533	16	[	[	-LRB-
cord-295807-68sukdb1	533	17	343	343	CD
cord-295807-68sukdb1	533	18	]	]	-RRB-
cord-295807-68sukdb1	533	19	and	and	CC
cord-295807-68sukdb1	533	20	dampened	dampen	VBN
cord-295807-68sukdb1	533	21	by	by	IN
cord-295807-68sukdb1	533	22	ASIC1a	ASIC1a	NNP
cord-295807-68sukdb1	533	23	disruption	disruption	NN
cord-295807-68sukdb1	533	24	[	[	-LRB-
cord-295807-68sukdb1	533	25	342	342	CD
cord-295807-68sukdb1	533	26	]	]	-RRB-
cord-295807-68sukdb1	533	27	.	.	.
cord-295807-68sukdb1	534	1	In	in	IN
cord-295807-68sukdb1	534	2	humans	human	NNS
cord-295807-68sukdb1	534	3	,	,	,
cord-295807-68sukdb1	534	4	decreased	decrease	VBD
cord-295807-68sukdb1	534	5	brain	brain	NN
cord-295807-68sukdb1	534	6	pH	ph	NN
cord-295807-68sukdb1	534	7	is	be	VBZ
cord-295807-68sukdb1	534	8	also	also	RB
cord-295807-68sukdb1	534	9	associated	associate	VBN
cord-295807-68sukdb1	534	10	with	with	IN
cord-295807-68sukdb1	534	11	schizophrenia	schizophrenia	NN
cord-295807-68sukdb1	534	12	,	,	,
cord-295807-68sukdb1	534	13	bipolar	bipolar	JJ
cord-295807-68sukdb1	534	14	disorder	disorder	NN
cord-295807-68sukdb1	534	15	,	,	,
cord-295807-68sukdb1	534	16	and	and	CC
cord-295807-68sukdb1	534	17	autism	autism	NN
cord-295807-68sukdb1	534	18	spectrum	spectrum	NN
cord-295807-68sukdb1	534	19	disorder	disorder	NN
cord-295807-68sukdb1	534	20	[	[	-LRB-
cord-295807-68sukdb1	534	21	344	344	CD
cord-295807-68sukdb1	534	22	]	]	-RRB-
cord-295807-68sukdb1	534	23	.	.	.
cord-295807-68sukdb1	535	1	One	one	CD
cord-295807-68sukdb1	535	2	study	study	NN
cord-295807-68sukdb1	535	3	even	even	RB
cord-295807-68sukdb1	535	4	suggests	suggest	VBZ
cord-295807-68sukdb1	535	5	that	that	IN
cord-295807-68sukdb1	535	6	a	a	DT
cord-295807-68sukdb1	535	7	high	high	JJ
cord-295807-68sukdb1	535	8	dietary	dietary	JJ
cord-295807-68sukdb1	535	9	acid	acid	NN
cord-295807-68sukdb1	535	10	load	load	NN
cord-295807-68sukdb1	535	11	correlates	correlate	VBZ
cord-295807-68sukdb1	535	12	with	with	IN
cord-295807-68sukdb1	535	13	incidence	incidence	NN
cord-295807-68sukdb1	535	14	of	of	IN
cord-295807-68sukdb1	535	15	emotional	emotional	JJ
cord-295807-68sukdb1	535	16	problems	problem	NNS
cord-295807-68sukdb1	535	17	and	and	CC
cord-295807-68sukdb1	535	18	hyperactivity	hyperactivity	NN
cord-295807-68sukdb1	535	19	in	in	IN
cord-295807-68sukdb1	535	20	young	young	JJ
cord-295807-68sukdb1	535	21	children	child	NNS
cord-295807-68sukdb1	535	22	,	,	,
cord-295807-68sukdb1	535	23	but	but	CC
cord-295807-68sukdb1	535	24	causality	causality	NN
cord-295807-68sukdb1	535	25	could	could	MD
cord-295807-68sukdb1	535	26	not	not	RB
cord-295807-68sukdb1	535	27	be	be	VB
cord-295807-68sukdb1	535	28	established	establish	VBN
cord-295807-68sukdb1	535	29	as	as	IN
cord-295807-68sukdb1	535	30	could	could	MD
cord-295807-68sukdb1	535	31	not	not	RB
cord-295807-68sukdb1	535	32	be	be	VB
cord-295807-68sukdb1	535	33	discounted	discount	VBN
cord-295807-68sukdb1	535	34	that	that	IN
cord-295807-68sukdb1	535	35	behavior	behavior	NN
cord-295807-68sukdb1	535	36	influences	influence	VBZ
cord-295807-68sukdb1	535	37	dietary	dietary	JJ
cord-295807-68sukdb1	535	38	habits	habit	NNS
cord-295807-68sukdb1	535	39	[	[	-LRB-
cord-295807-68sukdb1	535	40	345	345	CD
cord-295807-68sukdb1	535	41	]	]	-RRB-
cord-295807-68sukdb1	535	42	.	.	.
cord-295807-68sukdb1	536	1	In	in	IN
cord-295807-68sukdb1	536	2	terms	term	NNS
cord-295807-68sukdb1	536	3	of	of	IN
cord-295807-68sukdb1	536	4	the	the	DT
cord-295807-68sukdb1	536	5	linkage	linkage	NN
cord-295807-68sukdb1	536	6	between	between	IN
cord-295807-68sukdb1	536	7	ABTs	abts	NN
cord-295807-68sukdb1	536	8	and	and	CC
cord-295807-68sukdb1	536	9	neuropsychiatric	neuropsychiatric	JJ
cord-295807-68sukdb1	536	10	disorders	disorder	NNS
cord-295807-68sukdb1	536	11	,	,	,
cord-295807-68sukdb1	536	12	SLC4A4	SLC4A4	NNP
cord-295807-68sukdb1	536	13	is	be	VBZ
cord-295807-68sukdb1	536	14	a	a	DT
cord-295807-68sukdb1	536	15	biomarker	biomarker	NN
cord-295807-68sukdb1	536	16	(	(	-LRB-
cord-295807-68sukdb1	536	17	both	both	CC
cord-295807-68sukdb1	536	18	in	in	IN
cord-295807-68sukdb1	536	19	terms	term	NNS
cord-295807-68sukdb1	536	20	of	of	IN
cord-295807-68sukdb1	536	21	incidence	incidence	NN
cord-295807-68sukdb1	536	22	of	of	IN
cord-295807-68sukdb1	536	23	a	a	DT
cord-295807-68sukdb1	536	24	specific	specific	JJ
cord-295807-68sukdb1	536	25	single	single	JJ
cord-295807-68sukdb1	536	26	nucleotide	nucleotide	JJ
cord-295807-68sukdb1	536	27	polymorphism	polymorphism	NN
cord-295807-68sukdb1	536	28	and	and	CC
cord-295807-68sukdb1	536	29	in	in	IN
cord-295807-68sukdb1	536	30	terms	term	NNS
cord-295807-68sukdb1	536	31	of	of	IN
cord-295807-68sukdb1	536	32	reduced	reduced	JJ
cord-295807-68sukdb1	536	33	expression	expression	NN
cord-295807-68sukdb1	536	34	determined	determine	VBN
cord-295807-68sukdb1	536	35	by	by	IN
cord-295807-68sukdb1	536	36	microarray	microarray	NN
cord-295807-68sukdb1	536	37	)	)	-RRB-
cord-295807-68sukdb1	536	38	of	of	IN
cord-295807-68sukdb1	536	39	suicide	suicide	NN
cord-295807-68sukdb1	536	40	ideation	ideation	NN
cord-295807-68sukdb1	536	41	and	and	CC
cord-295807-68sukdb1	536	42	completion	completion	NN
cord-295807-68sukdb1	536	43	,	,	,
cord-295807-68sukdb1	536	44	especially	especially	RB
cord-295807-68sukdb1	536	45	with	with	IN
cord-295807-68sukdb1	536	46	bipolar	bipolar	JJ
cord-295807-68sukdb1	536	47	disorder	disorder	NN
cord-295807-68sukdb1	536	48	[	[	-LRB-
cord-295807-68sukdb1	536	49	346	346	CD
cord-295807-68sukdb1	536	50	]	]	-RRB-
cord-295807-68sukdb1	536	51	.	.	.
cord-295807-68sukdb1	537	1	Although	although	IN
cord-295807-68sukdb1	537	2	the	the	DT
cord-295807-68sukdb1	537	3	mechanistic	mechanistic	JJ
cord-295807-68sukdb1	537	4	details	detail	NNS
cord-295807-68sukdb1	537	5	of	of	IN
cord-295807-68sukdb1	537	6	the	the	DT
cord-295807-68sukdb1	537	7	linkage	linkage	NN
cord-295807-68sukdb1	537	8	are	be	VBP
cord-295807-68sukdb1	537	9	unknown	unknown	JJ
cord-295807-68sukdb1	537	10	,	,	,
cord-295807-68sukdb1	537	11	the	the	DT
cord-295807-68sukdb1	537	12	role	role	NN
cord-295807-68sukdb1	537	13	of	of	IN
cord-295807-68sukdb1	537	14	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	537	15	in	in	IN
cord-295807-68sukdb1	537	16	control	control	NN
cord-295807-68sukdb1	537	17	of	of	IN
cord-295807-68sukdb1	537	18	brain	brain	NN
cord-295807-68sukdb1	538	1	pH	pH	NNP
cord-295807-68sukdb1	538	2	is	be	VBZ
cord-295807-68sukdb1	538	3	likely	likely	JJ
cord-295807-68sukdb1	538	4	to	to	TO
cord-295807-68sukdb1	538	5	be	be	VB
cord-295807-68sukdb1	538	6	relevant	relevant	JJ
cord-295807-68sukdb1	538	7	.	.	.
cord-295807-68sukdb1	539	1	Perhaps	perhaps	RB
cord-295807-68sukdb1	539	2	also	also	RB
cord-295807-68sukdb1	539	3	of	of	IN
cord-295807-68sukdb1	539	4	tangential	tangential	JJ
cord-295807-68sukdb1	539	5	relevance	relevance	NN
cord-295807-68sukdb1	539	6	,	,	,
cord-295807-68sukdb1	539	7	due	due	IN
cord-295807-68sukdb1	539	8	to	to	IN
cord-295807-68sukdb1	539	9	its	-PRON-	PRP$
cord-295807-68sukdb1	539	10	impact	impact	NN
cord-295807-68sukdb1	539	11	upon	upon	IN
cord-295807-68sukdb1	539	12	systemic	systemic	JJ
cord-295807-68sukdb1	539	13	acid	acid	NN
cord-295807-68sukdb1	539	14	-	-	HYPH
cord-295807-68sukdb1	539	15	base	base	NN
cord-295807-68sukdb1	539	16	balance	balance	NN
cord-295807-68sukdb1	539	17	[	[	-LRB-
cord-295807-68sukdb1	539	18	347	347	CD
cord-295807-68sukdb1	539	19	]	]	-RRB-
cord-295807-68sukdb1	539	20	,	,	,
cord-295807-68sukdb1	539	21	is	be	VBZ
cord-295807-68sukdb1	539	22	that	that	DT
cord-295807-68sukdb1	539	23	estimated	estimate	VBN
cord-295807-68sukdb1	539	24	glomerular	glomerular	JJ
cord-295807-68sukdb1	539	25	filtration	filtration	NN
cord-295807-68sukdb1	539	26	rate	rate	NN
cord-295807-68sukdb1	539	27	in	in	IN
cord-295807-68sukdb1	539	28	CKD	CKD	NNP
cord-295807-68sukdb1	539	29	,	,	,
cord-295807-68sukdb1	539	30	which	which	WDT
cord-295807-68sukdb1	539	31	typically	typically	RB
cord-295807-68sukdb1	539	32	correlates	correlate	VBZ
cord-295807-68sukdb1	539	33	with	with	IN
cord-295807-68sukdb1	539	34	ability	ability	NN
cord-295807-68sukdb1	539	35	to	to	TO
cord-295807-68sukdb1	539	36	excrete	excrete	VB
cord-295807-68sukdb1	539	37	acid	acid	NN
cord-295807-68sukdb1	539	38	,	,	,
cord-295807-68sukdb1	539	39	is	be	VBZ
cord-295807-68sukdb1	539	40	inversely	inversely	RB
cord-295807-68sukdb1	539	41	correlated	correlate	VBN
cord-295807-68sukdb1	539	42	to	to	IN
cord-295807-68sukdb1	539	43	depressive	depressive	JJ
cord-295807-68sukdb1	539	44	symptoms	symptom	NNS
cord-295807-68sukdb1	539	45	and	and	CC
cord-295807-68sukdb1	539	46	suicide	suicide	NN
cord-295807-68sukdb1	539	47	ideation	ideation	NN
cord-295807-68sukdb1	539	48	[	[	-LRB-
cord-295807-68sukdb1	539	49	348	348	CD
cord-295807-68sukdb1	539	50	]	]	-RRB-
cord-295807-68sukdb1	539	51	.	.	.
cord-295807-68sukdb1	540	1	The	the	DT
cord-295807-68sukdb1	540	2	anxiety	anxiety	NN
cord-295807-68sukdb1	540	3	response	response	NN
cord-295807-68sukdb1	540	4	to	to	IN
cord-295807-68sukdb1	540	5	CO2	CO2	NNP
cord-295807-68sukdb1	540	6	inhalation	inhalation	NN
cord-295807-68sukdb1	540	7	is	be	VBZ
cord-295807-68sukdb1	540	8	a	a	DT
cord-295807-68sukdb1	540	9	useful	useful	JJ
cord-295807-68sukdb1	540	10	clinical	clinical	JJ
cord-295807-68sukdb1	540	11	test	test	NN
cord-295807-68sukdb1	540	12	to	to	TO
cord-295807-68sukdb1	540	13	follow	follow	VB
cord-295807-68sukdb1	540	14	the	the	DT
cord-295807-68sukdb1	540	15	effectiveness	effectiveness	NN
cord-295807-68sukdb1	540	16	of	of	IN
cord-295807-68sukdb1	540	17	treatments	treatment	NNS
cord-295807-68sukdb1	540	18	for	for	IN
cord-295807-68sukdb1	540	19	panic	panic	NN
cord-295807-68sukdb1	540	20	disorders	disorder	NNS
cord-295807-68sukdb1	540	21	[	[	-LRB-
cord-295807-68sukdb1	540	22	349	349	CD
cord-295807-68sukdb1	540	23	]	]	-RRB-
cord-295807-68sukdb1	540	24	.	.	.
cord-295807-68sukdb1	541	1	The	the	DT
cord-295807-68sukdb1	541	2	response	response	NN
cord-295807-68sukdb1	541	3	itself	-PRON-	PRP
cord-295807-68sukdb1	541	4	can	can	MD
cord-295807-68sukdb1	541	5	be	be	VB
cord-295807-68sukdb1	541	6	quelled	quell	VBN
cord-295807-68sukdb1	541	7	by	by	IN
cord-295807-68sukdb1	541	8	ACZ	ACZ	NNP
cord-295807-68sukdb1	541	9	[	[	-LRB-
cord-295807-68sukdb1	541	10	350	350	CD
cord-295807-68sukdb1	541	11	]	]	-RRB-
cord-295807-68sukdb1	542	1	but	but	CC
cord-295807-68sukdb1	542	2	,	,	,
cord-295807-68sukdb1	542	3	as	as	IN
cord-295807-68sukdb1	542	4	this	this	DT
cord-295807-68sukdb1	542	5	is	be	VBZ
cord-295807-68sukdb1	542	6	just	just	RB
cord-295807-68sukdb1	542	7	a	a	DT
cord-295807-68sukdb1	542	8	model	model	NN
cord-295807-68sukdb1	542	9	of	of	IN
cord-295807-68sukdb1	542	10	panic	panic	NN
cord-295807-68sukdb1	542	11	disorder	disorder	NN
cord-295807-68sukdb1	542	12	,	,	,
cord-295807-68sukdb1	542	13	the	the	DT
cord-295807-68sukdb1	542	14	use	use	NN
cord-295807-68sukdb1	542	15	of	of	IN
cord-295807-68sukdb1	542	16	CA	CA	NNP
cord-295807-68sukdb1	542	17	blockers	blocker	NNS
cord-295807-68sukdb1	542	18	to	to	TO
cord-295807-68sukdb1	542	19	treat	treat	VB
cord-295807-68sukdb1	542	20	actual	actual	JJ
cord-295807-68sukdb1	542	21	panic	panic	NN
cord-295807-68sukdb1	542	22	disorders	disorder	NNS
cord-295807-68sukdb1	542	23	is	be	VBZ
cord-295807-68sukdb1	542	24	unclear	unclear	JJ
cord-295807-68sukdb1	542	25	.	.	.
cord-295807-68sukdb1	543	1	The	the	DT
cord-295807-68sukdb1	543	2	above	above	RB
cord-295807-68sukdb1	543	3	-	-	HYPH
cord-295807-68sukdb1	543	4	mentioned	mention	VBN
cord-295807-68sukdb1	543	5	studies	study	NNS
cord-295807-68sukdb1	543	6	of	of	IN
cord-295807-68sukdb1	543	7	ASIC1a	ASIC1a	NNP
cord-295807-68sukdb1	543	8	-	-	HYPH
cord-295807-68sukdb1	543	9	null	null	JJ
cord-295807-68sukdb1	543	10	mice	mouse	NNS
cord-295807-68sukdb1	543	11	suggest	suggest	VBP
cord-295807-68sukdb1	543	12	that	that	IN
cord-295807-68sukdb1	543	13	ASIC1a	ASIC1a	NNP
cord-295807-68sukdb1	543	14	inhibition	inhibition	NN
cord-295807-68sukdb1	543	15	could	could	MD
cord-295807-68sukdb1	543	16	be	be	VB
cord-295807-68sukdb1	543	17	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	543	18	for	for	IN
cord-295807-68sukdb1	543	19	panic	panic	NN
cord-295807-68sukdb1	543	20	disorder	disorder	NN
cord-295807-68sukdb1	543	21	.	.	.
cord-295807-68sukdb1	544	1	Regarding	regard	VBG
cord-295807-68sukdb1	544	2	the	the	DT
cord-295807-68sukdb1	544	3	link	link	NN
cord-295807-68sukdb1	544	4	between	between	IN
cord-295807-68sukdb1	544	5	SLC4A4	SLC4A4	NNP
cord-295807-68sukdb1	544	6	and	and	CC
cord-295807-68sukdb1	544	7	suicide	suicide	NN
cord-295807-68sukdb1	544	8	,	,	,
cord-295807-68sukdb1	544	9	It	-PRON-	PRP
cord-295807-68sukdb1	544	10	is	be	VBZ
cord-295807-68sukdb1	544	11	unclear	unclear	JJ
cord-295807-68sukdb1	544	12	how	how	WRB
cord-295807-68sukdb1	544	13	modulating	modulate	VBG
cord-295807-68sukdb1	544	14	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	544	15	activity	activity	NN
cord-295807-68sukdb1	544	16	might	may	MD
cord-295807-68sukdb1	544	17	influence	influence	VB
cord-295807-68sukdb1	544	18	depression	depression	NN
cord-295807-68sukdb1	544	19	,	,	,
cord-295807-68sukdb1	544	20	although	although	IN
cord-295807-68sukdb1	544	21	detection	detection	NN
cord-295807-68sukdb1	544	22	of	of	IN
cord-295807-68sukdb1	544	23	the	the	DT
cord-295807-68sukdb1	544	24	biomarker	biomarker	NN
cord-295807-68sukdb1	544	25	could	could	MD
cord-295807-68sukdb1	544	26	help	help	VB
cord-295807-68sukdb1	544	27	to	to	TO
cord-295807-68sukdb1	544	28	identify	identify	VB
cord-295807-68sukdb1	544	29	high	high	JJ
cord-295807-68sukdb1	544	30	risk	risk	NN
cord-295807-68sukdb1	544	31	individuals	individual	NNS
cord-295807-68sukdb1	544	32	and	and	CC
cord-295807-68sukdb1	544	33	thereby	thereby	RB
cord-295807-68sukdb1	544	34	inform	inform	VB
cord-295807-68sukdb1	544	35	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	544	36	strategies	strategy	NNS
cord-295807-68sukdb1	544	37	[	[	-LRB-
cord-295807-68sukdb1	544	38	346	346	CD
cord-295807-68sukdb1	544	39	]	]	-RRB-
cord-295807-68sukdb1	544	40	.	.	.
cord-295807-68sukdb1	545	1	Finally	finally	RB
cord-295807-68sukdb1	545	2	,	,	,
cord-295807-68sukdb1	545	3	it	-PRON-	PRP
cord-295807-68sukdb1	545	4	has	have	VBZ
cord-295807-68sukdb1	545	5	been	be	VBN
cord-295807-68sukdb1	545	6	suggested	suggest	VBN
cord-295807-68sukdb1	545	7	that	that	IN
cord-295807-68sukdb1	545	8	antipsychotic	antipsychotic	JJ
cord-295807-68sukdb1	545	9	medications	medication	NNS
cord-295807-68sukdb1	545	10	could	could	MD
cord-295807-68sukdb1	545	11	contribute	contribute	VB
cord-295807-68sukdb1	545	12	to	to	IN
cord-295807-68sukdb1	545	13	lactic	lactic	JJ
cord-295807-68sukdb1	545	14	acidosis	acidosis	NN
cord-295807-68sukdb1	545	15	and	and	CC
cord-295807-68sukdb1	545	16	be	be	VB
cord-295807-68sukdb1	545	17	partly	partly	RB
cord-295807-68sukdb1	545	18	responsible	responsible	JJ
cord-295807-68sukdb1	545	19	for	for	IN
cord-295807-68sukdb1	545	20	decreased	decrease	VBN
cord-295807-68sukdb1	545	21	pH	ph	NN
cord-295807-68sukdb1	545	22	in	in	IN
cord-295807-68sukdb1	545	23	the	the	DT
cord-295807-68sukdb1	545	24	brains	brain	NNS
cord-295807-68sukdb1	545	25	of	of	IN
cord-295807-68sukdb1	545	26	individuals	individual	NNS
cord-295807-68sukdb1	545	27	with	with	IN
cord-295807-68sukdb1	545	28	schizophrenia	schizophrenia	NN
cord-295807-68sukdb1	545	29	[	[	-LRB-
cord-295807-68sukdb1	545	30	351	351	CD
cord-295807-68sukdb1	545	31	]	]	-RRB-
cord-295807-68sukdb1	545	32	.	.	.
cord-295807-68sukdb1	546	1	As	as	IN
cord-295807-68sukdb1	546	2	mentioned	mention	VBN
cord-295807-68sukdb1	546	3	previously	previously	RB
cord-295807-68sukdb1	546	4	,	,	,
cord-295807-68sukdb1	546	5	plasma	plasma	NN
cord-295807-68sukdb1	546	6	pH	ph	NN
cord-295807-68sukdb1	546	7	depends	depend	VBZ
cord-295807-68sukdb1	546	8	on	on	IN
cord-295807-68sukdb1	546	9	adequate	adequate	JJ
cord-295807-68sukdb1	546	10	ventilation	ventilation	NN
cord-295807-68sukdb1	546	11	to	to	TO
cord-295807-68sukdb1	546	12	exhaust	exhaust	VB
cord-295807-68sukdb1	546	13	CO2	co2	NN
cord-295807-68sukdb1	546	14	thus	thus	RB
cord-295807-68sukdb1	546	15	mechanical	mechanical	JJ
cord-295807-68sukdb1	546	16	ventilation	ventilation	NN
cord-295807-68sukdb1	546	17	can	can	MD
cord-295807-68sukdb1	546	18	induce	induce	VB
cord-295807-68sukdb1	546	19	respiratory	respiratory	JJ
cord-295807-68sukdb1	546	20	acid	acid	NN
cord-295807-68sukdb1	546	21	-	-	HYPH
cord-295807-68sukdb1	546	22	base	base	NN
cord-295807-68sukdb1	546	23	disturbances	disturbance	NNS
cord-295807-68sukdb1	546	24	.	.	.
cord-295807-68sukdb1	547	1	Another	another	DT
cord-295807-68sukdb1	547	2	important	important	JJ
cord-295807-68sukdb1	547	3	aspect	aspect	NN
cord-295807-68sukdb1	547	4	for	for	IN
cord-295807-68sukdb1	547	5	consideration	consideration	NN
cord-295807-68sukdb1	547	6	in	in	IN
cord-295807-68sukdb1	547	7	this	this	DT
cord-295807-68sukdb1	547	8	section	section	NN
cord-295807-68sukdb1	547	9	is	be	VBZ
cord-295807-68sukdb1	547	10	that	that	IN
cord-295807-68sukdb1	547	11	the	the	DT
cord-295807-68sukdb1	547	12	bioavailability	bioavailability	NN
cord-295807-68sukdb1	547	13	of	of	IN
cord-295807-68sukdb1	547	14	anesthetic	anesthetic	JJ
cord-295807-68sukdb1	547	15	agents	agent	NNS
cord-295807-68sukdb1	547	16	can	can	MD
cord-295807-68sukdb1	547	17	be	be	VB
cord-295807-68sukdb1	547	18	influenced	influence	VBN
cord-295807-68sukdb1	547	19	by	by	IN
cord-295807-68sukdb1	547	20	acid	acid	NN
cord-295807-68sukdb1	547	21	-	-	HYPH
cord-295807-68sukdb1	547	22	base	base	NN
cord-295807-68sukdb1	547	23	status	status	NN
cord-295807-68sukdb1	547	24	.	.	.
cord-295807-68sukdb1	548	1	When	when	WRB
cord-295807-68sukdb1	548	2	using	use	VBG
cord-295807-68sukdb1	548	3	mechanical	mechanical	JJ
cord-295807-68sukdb1	548	4	ventilation	ventilation	NN
cord-295807-68sukdb1	548	5	,	,	,
cord-295807-68sukdb1	548	6	two	two	CD
cord-295807-68sukdb1	548	7	important	important	JJ
cord-295807-68sukdb1	548	8	considerations	consideration	NNS
cord-295807-68sukdb1	548	9	,	,	,
cord-295807-68sukdb1	548	10	related	relate	VBN
cord-295807-68sukdb1	548	11	to	to	IN
cord-295807-68sukdb1	548	12	acid	acid	NN
cord-295807-68sukdb1	548	13	-	-	HYPH
cord-295807-68sukdb1	548	14	base	base	NN
cord-295807-68sukdb1	548	15	balance	balance	NN
cord-295807-68sukdb1	548	16	,	,	,
cord-295807-68sukdb1	548	17	must	must	MD
cord-295807-68sukdb1	548	18	be	be	VB
cord-295807-68sukdb1	548	19	raised	raise	VBN
cord-295807-68sukdb1	548	20	.	.	.
cord-295807-68sukdb1	549	1	The	the	DT
cord-295807-68sukdb1	549	2	first	first	JJ
cord-295807-68sukdb1	549	3	consideration	consideration	NN
cord-295807-68sukdb1	549	4	relates	relate	VBZ
cord-295807-68sukdb1	549	5	to	to	IN
cord-295807-68sukdb1	549	6	low	low	JJ
cord-295807-68sukdb1	549	7	-	-	HYPH
cord-295807-68sukdb1	549	8	flow	flow	NN
cord-295807-68sukdb1	549	9	anesthesia	anesthesia	NN
cord-295807-68sukdb1	549	10	or	or	CC
cord-295807-68sukdb1	549	11	closed	close	VBN
cord-295807-68sukdb1	549	12	-	-	HYPH
cord-295807-68sukdb1	549	13	circuit	circuit	NN
cord-295807-68sukdb1	549	14	rebreathing	rebreathing	NN
cord-295807-68sukdb1	549	15	systems	system	NNS
cord-295807-68sukdb1	549	16	that	that	WDT
cord-295807-68sukdb1	549	17	return	return	VBP
cord-295807-68sukdb1	549	18	exhaled	exhale	VBD
cord-295807-68sukdb1	549	19	anesthetic	anesthetic	JJ
cord-295807-68sukdb1	549	20	gas	gas	NN
cord-295807-68sukdb1	549	21	mixtures	mixture	NNS
cord-295807-68sukdb1	549	22	.	.	.
cord-295807-68sukdb1	550	1	In	in	IN
cord-295807-68sukdb1	550	2	these	these	DT
cord-295807-68sukdb1	550	3	systems	system	NNS
cord-295807-68sukdb1	550	4	CO2	CO2	NNP
cord-295807-68sukdb1	550	5	must	must	MD
cord-295807-68sukdb1	550	6	be	be	VB
cord-295807-68sukdb1	550	7	removed	remove	VBN
cord-295807-68sukdb1	550	8	from	from	IN
cord-295807-68sukdb1	550	9	the	the	DT
cord-295807-68sukdb1	550	10	recirculated	recirculate	VBN
cord-295807-68sukdb1	550	11	air	air	NN
cord-295807-68sukdb1	550	12	.	.	.
cord-295807-68sukdb1	551	1	For	for	IN
cord-295807-68sukdb1	551	2	this	this	DT
cord-295807-68sukdb1	551	3	purpose	purpose	NN
cord-295807-68sukdb1	551	4	,	,	,
cord-295807-68sukdb1	551	5	CO2	CO2	NNP
cord-295807-68sukdb1	551	6	scrubbers	scrubber	NNS
cord-295807-68sukdb1	551	7	are	be	VBP
cord-295807-68sukdb1	551	8	used	use	VBN
cord-295807-68sukdb1	551	9	to	to	TO
cord-295807-68sukdb1	551	10	adsorb	adsorb	VB
cord-295807-68sukdb1	551	11	CO2	CO2	NNP
cord-295807-68sukdb1	551	12	.	.	.
cord-295807-68sukdb1	552	1	The	the	DT
cord-295807-68sukdb1	552	2	archetypal	archetypal	JJ
cord-295807-68sukdb1	552	3	scrubber	scrubber	NN
cord-295807-68sukdb1	552	4	is	be	VBZ
cord-295807-68sukdb1	552	5	soda	soda	NN
cord-295807-68sukdb1	552	6	lime	lime	NN
cord-295807-68sukdb1	552	7	(	(	-LRB-
cord-295807-68sukdb1	552	8	a	a	DT
cord-295807-68sukdb1	552	9	mixture	mixture	NN
cord-295807-68sukdb1	552	10	of	of	IN
cord-295807-68sukdb1	552	11	NaOH	NaOH	NNP
cord-295807-68sukdb1	552	12	and	and	CC
cord-295807-68sukdb1	552	13	Ca(OH)2	Ca(OH)2	NNP
cord-295807-68sukdb1	552	14	,	,	,
cord-295807-68sukdb1	552	15	which	which	WDT
cord-295807-68sukdb1	552	16	reacts	react	VBZ
cord-295807-68sukdb1	552	17	with	with	IN
cord-295807-68sukdb1	552	18	carbonic	carbonic	JJ
cord-295807-68sukdb1	552	19	acid	acid	NN
cord-295807-68sukdb1	552	20	to	to	TO
cord-295807-68sukdb1	552	21	form	form	VB
cord-295807-68sukdb1	552	22	an	an	DT
cord-295807-68sukdb1	552	23	insoluble	insoluble	JJ
cord-295807-68sukdb1	552	24	CaCO3	caco3	NN
cord-295807-68sukdb1	552	25	precipitate	precipitate	NN
cord-295807-68sukdb1	552	26	)	)	-RRB-
cord-295807-68sukdb1	552	27	,	,	,
cord-295807-68sukdb1	552	28	although	although	IN
cord-295807-68sukdb1	552	29	a	a	DT
cord-295807-68sukdb1	552	30	number	number	NN
cord-295807-68sukdb1	552	31	of	of	IN
cord-295807-68sukdb1	552	32	other	other	JJ
cord-295807-68sukdb1	552	33	technologies	technology	NNS
cord-295807-68sukdb1	552	34	are	be	VBP
cord-295807-68sukdb1	552	35	available	available	JJ
cord-295807-68sukdb1	552	36	[	[	-LRB-
cord-295807-68sukdb1	552	37	352	352	CD
cord-295807-68sukdb1	552	38	,	,	,
cord-295807-68sukdb1	552	39	353	353	CD
cord-295807-68sukdb1	552	40	]	]	-RRB-
cord-295807-68sukdb1	552	41	(	(	-LRB-
cord-295807-68sukdb1	552	42	see	see	VB
cord-295807-68sukdb1	552	43	also	also	RB
cord-295807-68sukdb1	552	44	section	section	NN
cord-295807-68sukdb1	552	45	3.4.2	3.4.2	CD
cord-295807-68sukdb1	552	46	)	)	-RRB-
cord-295807-68sukdb1	552	47	.	.	.
cord-295807-68sukdb1	553	1	The	the	DT
cord-295807-68sukdb1	553	2	choice	choice	NN
cord-295807-68sukdb1	553	3	of	of	IN
cord-295807-68sukdb1	553	4	technology	technology	NN
cord-295807-68sukdb1	553	5	can	can	MD
cord-295807-68sukdb1	553	6	be	be	VB
cord-295807-68sukdb1	553	7	important	important	JJ
cord-295807-68sukdb1	553	8	as	as	IN
cord-295807-68sukdb1	553	9	many	many	JJ
cord-295807-68sukdb1	553	10	CO2	CO2	NNP
cord-295807-68sukdb1	553	11	scrubbers	scrubber	NNS
cord-295807-68sukdb1	553	12	can	can	MD
cord-295807-68sukdb1	553	13	have	have	VB
cord-295807-68sukdb1	553	14	undesirable	undesirable	JJ
cord-295807-68sukdb1	553	15	reactions	reaction	NNS
cord-295807-68sukdb1	553	16	with	with	IN
cord-295807-68sukdb1	553	17	anesthetic	anesthetic	JJ
cord-295807-68sukdb1	553	18	gases	gas	NNS
cord-295807-68sukdb1	553	19	,	,	,
cord-295807-68sukdb1	553	20	producing	produce	VBG
cord-295807-68sukdb1	553	21	toxins	toxin	NNS
cord-295807-68sukdb1	553	22	such	such	JJ
cord-295807-68sukdb1	553	23	as	as	IN
cord-295807-68sukdb1	553	24	carbon	carbon	NN
cord-295807-68sukdb1	553	25	monoxide	monoxide	NN
cord-295807-68sukdb1	553	26	[	[	-LRB-
cord-295807-68sukdb1	553	27	354	354	CD
cord-295807-68sukdb1	553	28	]	]	-RRB-
cord-295807-68sukdb1	553	29	.	.	.
cord-295807-68sukdb1	554	1	The	the	DT
cord-295807-68sukdb1	554	2	second	second	JJ
cord-295807-68sukdb1	554	3	consideration	consideration	NN
cord-295807-68sukdb1	554	4	is	be	VBZ
cord-295807-68sukdb1	554	5	for	for	IN
cord-295807-68sukdb1	554	6	individuals	individual	NNS
cord-295807-68sukdb1	554	7	in	in	IN
cord-295807-68sukdb1	554	8	which	which	WDT
cord-295807-68sukdb1	554	9	low	low	RB
cord-295807-68sukdb1	554	10	-	-	HYPH
cord-295807-68sukdb1	554	11	tidal	tidal	JJ
cord-295807-68sukdb1	554	12	-	-	HYPH
cord-295807-68sukdb1	554	13	volume	volume	NN
cord-295807-68sukdb1	554	14	ventilation	ventilation	NN
cord-295807-68sukdb1	554	15	is	be	VBZ
cord-295807-68sukdb1	554	16	indicated	indicate	VBN
cord-295807-68sukdb1	554	17	,	,	,
cord-295807-68sukdb1	554	18	such	such	JJ
cord-295807-68sukdb1	554	19	as	as	IN
cord-295807-68sukdb1	554	20	those	those	DT
cord-295807-68sukdb1	554	21	with	with	IN
cord-295807-68sukdb1	554	22	acute	acute	JJ
cord-295807-68sukdb1	554	23	respiratory	respiratory	JJ
cord-295807-68sukdb1	554	24	distress	distress	NN
cord-295807-68sukdb1	554	25	syndrome	syndrome	NN
cord-295807-68sukdb1	554	26	or	or	CC
cord-295807-68sukdb1	554	27	COPD	COPD	NNP
cord-295807-68sukdb1	554	28	.	.	.
cord-295807-68sukdb1	555	1	These	these	DT
cord-295807-68sukdb1	555	2	individuals	individual	NNS
cord-295807-68sukdb1	555	3	may	may	MD
cord-295807-68sukdb1	555	4	be	be	VB
cord-295807-68sukdb1	555	5	deliberately	deliberately	RB
cord-295807-68sukdb1	555	6	under	under	RB
cord-295807-68sukdb1	555	7	-	-	HYPH
cord-295807-68sukdb1	555	8	ventilated	ventilate	VBN
cord-295807-68sukdb1	555	9	to	to	TO
cord-295807-68sukdb1	555	10	prevent	prevent	VB
cord-295807-68sukdb1	555	11	mechanical	mechanical	JJ
cord-295807-68sukdb1	555	12	stress	stress	NN
cord-295807-68sukdb1	555	13	on	on	IN
cord-295807-68sukdb1	555	14	the	the	DT
cord-295807-68sukdb1	555	15	lungs	lung	NNS
cord-295807-68sukdb1	555	16	.	.	.
cord-295807-68sukdb1	556	1	Thus	thus	RB
cord-295807-68sukdb1	556	2	,	,	,
cord-295807-68sukdb1	556	3	patients	patient	NNS
cord-295807-68sukdb1	556	4	are	be	VBP
cord-295807-68sukdb1	556	5	maintained	maintain	VBN
cord-295807-68sukdb1	556	6	in	in	IN
cord-295807-68sukdb1	556	7	a	a	DT
cord-295807-68sukdb1	556	8	state	state	NN
cord-295807-68sukdb1	556	9	of	of	IN
cord-295807-68sukdb1	556	10	compensated	compensate	VBN
cord-295807-68sukdb1	556	11	RAc	RAc	NNS
cord-295807-68sukdb1	556	12	called	call	VBN
cord-295807-68sukdb1	556	13	"	"	``
cord-295807-68sukdb1	556	14	permissive	permissive	JJ
cord-295807-68sukdb1	556	15	hypercapnia	hypercapnia	NN
cord-295807-68sukdb1	556	16	"	"	''
cord-295807-68sukdb1	556	17	.	.	.
cord-295807-68sukdb1	557	1	Under	under	IN
cord-295807-68sukdb1	557	2	some	some	DT
cord-295807-68sukdb1	557	3	circumstances	circumstance	NNS
cord-295807-68sukdb1	557	4	,	,	,
cord-295807-68sukdb1	557	5	such	such	JJ
cord-295807-68sukdb1	557	6	as	as	IN
cord-295807-68sukdb1	557	7	in	in	IN
cord-295807-68sukdb1	557	8	critically	critically	RB
cord-295807-68sukdb1	557	9	ill	ill	JJ
cord-295807-68sukdb1	557	10	patients	patient	NNS
cord-295807-68sukdb1	557	11	,	,	,
cord-295807-68sukdb1	557	12	this	this	DT
cord-295807-68sukdb1	557	13	hypercapnic	hypercapnic	NNP
cord-295807-68sukdb1	557	14	state	state	NN
cord-295807-68sukdb1	557	15	may	may	MD
cord-295807-68sukdb1	557	16	be	be	VB
cord-295807-68sukdb1	557	17	protective	protective	JJ
cord-295807-68sukdb1	557	18	due	due	IN
cord-295807-68sukdb1	557	19	to	to	IN
cord-295807-68sukdb1	557	20	its	-PRON-	PRP$
cord-295807-68sukdb1	557	21	anti	anti	JJ
cord-295807-68sukdb1	557	22	-	-	JJ
cord-295807-68sukdb1	557	23	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	557	24	influence	influence	NN
cord-295807-68sukdb1	557	25	[	[	-LRB-
cord-295807-68sukdb1	557	26	355	355	CD
cord-295807-68sukdb1	557	27	]	]	-RRB-
cord-295807-68sukdb1	557	28	(	(	-LRB-
cord-295807-68sukdb1	557	29	see	see	VB
cord-295807-68sukdb1	557	30	also	also	RB
cord-295807-68sukdb1	557	31	The	the	DT
cord-295807-68sukdb1	557	32	Immune	Immune	NNP
cord-295807-68sukdb1	557	33	System	System	NNP
cord-295807-68sukdb1	557	34	)	)	-RRB-
cord-295807-68sukdb1	557	35	.	.	.
cord-295807-68sukdb1	558	1	Acid	acid	NN
cord-295807-68sukdb1	558	2	-	-	HYPH
cord-295807-68sukdb1	558	3	base	base	NN
cord-295807-68sukdb1	558	4	balance	balance	NN
cord-295807-68sukdb1	558	5	concerns	concern	NNS
cord-295807-68sukdb1	558	6	are	be	VBP
cord-295807-68sukdb1	558	7	not	not	RB
cord-295807-68sukdb1	558	8	limited	limit	VBN
cord-295807-68sukdb1	558	9	to	to	IN
cord-295807-68sukdb1	558	10	inhaled	inhale	VBN
cord-295807-68sukdb1	558	11	anesthetics	anesthetic	NNS
cord-295807-68sukdb1	558	12	.	.	.
cord-295807-68sukdb1	559	1	Prolonged	prolonged	JJ
cord-295807-68sukdb1	559	2	infusion	infusion	NN
cord-295807-68sukdb1	559	3	with	with	IN
cord-295807-68sukdb1	559	4	the	the	DT
cord-295807-68sukdb1	559	5	intravenously	intravenously	RB
cord-295807-68sukdb1	559	6	administered	administer	VBN
cord-295807-68sukdb1	559	7	anesthetic	anesthetic	NN
cord-295807-68sukdb1	559	8	propofol	propofol	NN
cord-295807-68sukdb1	559	9	can	can	MD
cord-295807-68sukdb1	559	10	cause	cause	VB
cord-295807-68sukdb1	559	11	severe	severe	JJ
cord-295807-68sukdb1	559	12	lactic	lactic	JJ
cord-295807-68sukdb1	559	13	acidosis	acidosis	NN
cord-295807-68sukdb1	559	14	[	[	-LRB-
cord-295807-68sukdb1	559	15	356	356	CD
cord-295807-68sukdb1	559	16	]	]	-RRB-
cord-295807-68sukdb1	559	17	.	.	.
cord-295807-68sukdb1	560	1	The	the	DT
cord-295807-68sukdb1	560	2	influence	influence	NN
cord-295807-68sukdb1	560	3	of	of	IN
cord-295807-68sukdb1	560	4	pH	ph	NN
cord-295807-68sukdb1	560	5	on	on	IN
cord-295807-68sukdb1	560	6	the	the	DT
cord-295807-68sukdb1	560	7	pharmacokinetics	pharmacokinetic	NNS
cord-295807-68sukdb1	560	8	of	of	IN
cord-295807-68sukdb1	560	9	drugs	drug	NNS
cord-295807-68sukdb1	560	10	in	in	IN
cord-295807-68sukdb1	560	11	general	general	JJ
cord-295807-68sukdb1	560	12	is	be	VBZ
cord-295807-68sukdb1	560	13	discussed	discuss	VBN
cord-295807-68sukdb1	560	14	in	in	IN
cord-295807-68sukdb1	560	15	section	section	NN
cord-295807-68sukdb1	560	16	6	6	CD
cord-295807-68sukdb1	560	17	.	.	.
cord-295807-68sukdb1	561	1	Perioperative	perioperative	JJ
cord-295807-68sukdb1	561	2	interventions	intervention	NNS
cord-295807-68sukdb1	561	3	have	have	VBP
cord-295807-68sukdb1	561	4	the	the	DT
cord-295807-68sukdb1	561	5	potential	potential	NN
cord-295807-68sukdb1	561	6	to	to	TO
cord-295807-68sukdb1	561	7	disturb	disturb	VB
cord-295807-68sukdb1	561	8	acid	acid	NN
cord-295807-68sukdb1	561	9	-	-	HYPH
cord-295807-68sukdb1	561	10	base	base	NN
cord-295807-68sukdb1	561	11	homeostasis	homeostasis	NN
cord-295807-68sukdb1	561	12	with	with	IN
cord-295807-68sukdb1	561	13	negative	negative	JJ
cord-295807-68sukdb1	561	14	consequences	consequence	NNS
cord-295807-68sukdb1	561	15	for	for	IN
cord-295807-68sukdb1	561	16	outcome	outcome	NN
cord-295807-68sukdb1	561	17	.	.	.
cord-295807-68sukdb1	562	1	Post	post	JJ
cord-295807-68sukdb1	562	2	-	-	JJ
cord-295807-68sukdb1	562	3	operative	operative	JJ
cord-295807-68sukdb1	562	4	metabolic	metabolic	JJ
cord-295807-68sukdb1	562	5	acidosis	acidosis	NN
cord-295807-68sukdb1	562	6	is	be	VBZ
cord-295807-68sukdb1	562	7	a	a	DT
cord-295807-68sukdb1	562	8	well	well	RB
cord-295807-68sukdb1	562	9	described	describe	VBN
cord-295807-68sukdb1	562	10	but	but	CC
cord-295807-68sukdb1	562	11	complex	complex	JJ
cord-295807-68sukdb1	562	12	phenomenon	phenomenon	NN
cord-295807-68sukdb1	562	13	related	relate	VBN
cord-295807-68sukdb1	562	14	to	to	IN
cord-295807-68sukdb1	562	15	issues	issue	NNS
cord-295807-68sukdb1	562	16	including	include	VBG
cord-295807-68sukdb1	562	17	lactate	lactate	NN
cord-295807-68sukdb1	562	18	accumulation	accumulation	NN
cord-295807-68sukdb1	562	19	in	in	IN
cord-295807-68sukdb1	562	20	poorly	poorly	RB
cord-295807-68sukdb1	562	21	perfused	perfuse	VBN
cord-295807-68sukdb1	562	22	tissues	tissue	NNS
cord-295807-68sukdb1	562	23	and	and	CC
cord-295807-68sukdb1	562	24	hyperchloremic	hyperchloremic	JJ
cord-295807-68sukdb1	562	25	acidosis	acidosis	NN
cord-295807-68sukdb1	562	26	due	due	IN
cord-295807-68sukdb1	562	27	to	to	IN
cord-295807-68sukdb1	562	28	dilution	dilution	NN
cord-295807-68sukdb1	562	29	/	/	SYM
cord-295807-68sukdb1	562	30	displacement	displacement	NN
cord-295807-68sukdb1	562	31	of	of	IN
cord-295807-68sukdb1	562	32	HCO3	HCO3	NNP
cord-295807-68sukdb1	562	33	--containing	--containe	VBG
cord-295807-68sukdb1	562	34	plasma	plasma	NN
cord-295807-68sukdb1	562	35	by	by	IN
cord-295807-68sukdb1	562	36	infused	infuse	VBN
cord-295807-68sukdb1	562	37	saline	saline	NN
cord-295807-68sukdb1	562	38	[	[	-LRB-
cord-295807-68sukdb1	562	39	357	357	CD
cord-295807-68sukdb1	562	40	]	]	-RRB-
cord-295807-68sukdb1	562	41	[	[	-LRB-
cord-295807-68sukdb1	562	42	358	358	CD
cord-295807-68sukdb1	562	43	]	]	-RRB-
cord-295807-68sukdb1	562	44	[	[	-LRB-
cord-295807-68sukdb1	562	45	359	359	CD
cord-295807-68sukdb1	562	46	]	]	-RRB-
cord-295807-68sukdb1	562	47	[	[	-LRB-
cord-295807-68sukdb1	562	48	360	360	CD
cord-295807-68sukdb1	562	49	]	]	-RRB-
cord-295807-68sukdb1	562	50	.	.	.
cord-295807-68sukdb1	563	1	Pre	pre	JJ
cord-295807-68sukdb1	563	2	-	-	JJ
cord-295807-68sukdb1	563	3	operative	operative	JJ
cord-295807-68sukdb1	563	4	acidosis	acidosis	NN
cord-295807-68sukdb1	563	5	has	have	VBZ
cord-295807-68sukdb1	563	6	also	also	RB
cord-295807-68sukdb1	563	7	been	be	VBN
cord-295807-68sukdb1	563	8	described	describe	VBN
cord-295807-68sukdb1	563	9	and	and	CC
cord-295807-68sukdb1	563	10	has	have	VBZ
cord-295807-68sukdb1	563	11	been	be	VBN
cord-295807-68sukdb1	563	12	linked	link	VBN
cord-295807-68sukdb1	563	13	to	to	IN
cord-295807-68sukdb1	563	14	stress	stress	NN
cord-295807-68sukdb1	563	15	and	and	CC
cord-295807-68sukdb1	563	16	fasting	fast	VBG
cord-295807-68sukdb1	563	17	[	[	-LRB-
cord-295807-68sukdb1	563	18	357	357	CD
cord-295807-68sukdb1	563	19	]	]	-RRB-
cord-295807-68sukdb1	563	20	.	.	.
cord-295807-68sukdb1	564	1	Post	post	JJ
cord-295807-68sukdb1	564	2	-	-	JJ
cord-295807-68sukdb1	564	3	operative	operative	JJ
cord-295807-68sukdb1	564	4	MAlk	MAlk	NNP
cord-295807-68sukdb1	564	5	has	have	VBZ
cord-295807-68sukdb1	564	6	also	also	RB
cord-295807-68sukdb1	564	7	been	be	VBN
cord-295807-68sukdb1	564	8	described	describe	VBN
cord-295807-68sukdb1	564	9	following	follow	VBG
cord-295807-68sukdb1	564	10	general	general	JJ
cord-295807-68sukdb1	564	11	surgery	surgery	NN
cord-295807-68sukdb1	564	12	and	and	CC
cord-295807-68sukdb1	564	13	has	have	VBZ
cord-295807-68sukdb1	564	14	been	be	VBN
cord-295807-68sukdb1	564	15	linked	link	VBN
cord-295807-68sukdb1	564	16	to	to	IN
cord-295807-68sukdb1	564	17	the	the	DT
cord-295807-68sukdb1	564	18	infusion	infusion	NN
cord-295807-68sukdb1	564	19	of	of	IN
cord-295807-68sukdb1	564	20	citrate	citrate	NN
cord-295807-68sukdb1	564	21	-	-	HYPH
cord-295807-68sukdb1	564	22	buffered	buffer	VBN
cord-295807-68sukdb1	564	23	plasma	plasma	NN
cord-295807-68sukdb1	564	24	[	[	-LRB-
cord-295807-68sukdb1	564	25	361	361	CD
cord-295807-68sukdb1	564	26	,	,	,
cord-295807-68sukdb1	564	27	362	362	CD
cord-295807-68sukdb1	564	28	]	]	-RRB-
cord-295807-68sukdb1	564	29	.	.	.
cord-295807-68sukdb1	565	1	Peri	peri	JJ
cord-295807-68sukdb1	565	2	-	-	HYPH
cord-295807-68sukdb1	565	3	operative	operative	JJ
cord-295807-68sukdb1	565	4	MAlk	MAlk	NNP
cord-295807-68sukdb1	565	5	is	be	VBZ
cord-295807-68sukdb1	565	6	linked	link	VBN
cord-295807-68sukdb1	565	7	to	to	IN
cord-295807-68sukdb1	565	8	the	the	DT
cord-295807-68sukdb1	565	9	removal	removal	NN
cord-295807-68sukdb1	565	10	of	of	IN
cord-295807-68sukdb1	565	11	stomach	stomach	NN
cord-295807-68sukdb1	565	12	acid	acid	NN
cord-295807-68sukdb1	565	13	by	by	IN
cord-295807-68sukdb1	565	14	nasogastric	nasogastric	NN
cord-295807-68sukdb1	565	15	suction	suction	NN
cord-295807-68sukdb1	565	16	.	.	.
cord-295807-68sukdb1	566	1	Poor	poor	JJ
cord-295807-68sukdb1	566	2	outcomes	outcome	NNS
cord-295807-68sukdb1	566	3	have	have	VBP
cord-295807-68sukdb1	566	4	been	be	VBN
cord-295807-68sukdb1	566	5	associated	associate	VBN
cord-295807-68sukdb1	566	6	with	with	IN
cord-295807-68sukdb1	566	7	both	both	DT
cord-295807-68sukdb1	566	8	post	post	JJ
cord-295807-68sukdb1	566	9	-	-	JJ
cord-295807-68sukdb1	566	10	operative	operative	JJ
cord-295807-68sukdb1	566	11	MAc	MAc	NNP
cord-295807-68sukdb1	566	12	[	[	-LRB-
cord-295807-68sukdb1	566	13	363	363	CD
cord-295807-68sukdb1	566	14	]	]	-RRB-
cord-295807-68sukdb1	566	15	and	and	CC
cord-295807-68sukdb1	566	16	MAlk	malk	JJ
cord-295807-68sukdb1	566	17	[	[	-LRB-
cord-295807-68sukdb1	566	18	361	361	CD
cord-295807-68sukdb1	566	19	]	]	-RRB-
cord-295807-68sukdb1	566	20	,	,	,
cord-295807-68sukdb1	566	21	although	although	IN
cord-295807-68sukdb1	566	22	this	this	DT
cord-295807-68sukdb1	566	23	is	be	VBZ
cord-295807-68sukdb1	566	24	not	not	RB
cord-295807-68sukdb1	566	25	a	a	DT
cord-295807-68sukdb1	566	26	universal	universal	JJ
cord-295807-68sukdb1	566	27	finding	finding	NN
cord-295807-68sukdb1	566	28	[	[	-LRB-
cord-295807-68sukdb1	566	29	357	357	CD
cord-295807-68sukdb1	566	30	]	]	-RRB-
cord-295807-68sukdb1	566	31	.	.	.
cord-295807-68sukdb1	567	1	On	on	IN
cord-295807-68sukdb1	567	2	a	a	DT
cord-295807-68sukdb1	567	3	related	related	JJ
cord-295807-68sukdb1	567	4	theme	theme	NN
cord-295807-68sukdb1	567	5	,	,	,
cord-295807-68sukdb1	567	6	the	the	DT
cord-295807-68sukdb1	567	7	usefulness	usefulness	NN
cord-295807-68sukdb1	567	8	of	of	IN
cord-295807-68sukdb1	567	9	stored	store	VBN
cord-295807-68sukdb1	567	10	blood	blood	NN
cord-295807-68sukdb1	567	11	for	for	IN
cord-295807-68sukdb1	567	12	transfusion	transfusion	NN
cord-295807-68sukdb1	567	13	can	can	MD
cord-295807-68sukdb1	567	14	be	be	VB
cord-295807-68sukdb1	567	15	compromised	compromise	VBN
cord-295807-68sukdb1	567	16	by	by	IN
cord-295807-68sukdb1	567	17	numerous	numerous	JJ
cord-295807-68sukdb1	567	18	storage	storage	NN
cord-295807-68sukdb1	567	19	lesions	lesion	NNS
cord-295807-68sukdb1	567	20	including	include	VBG
cord-295807-68sukdb1	567	21	low	low	JJ
cord-295807-68sukdb1	567	22	pH	ph	NN
cord-295807-68sukdb1	567	23	that	that	WDT
cord-295807-68sukdb1	567	24	follows	follow	VBZ
cord-295807-68sukdb1	567	25	anaerobic	anaerobic	JJ
cord-295807-68sukdb1	567	26	metabolism	metabolism	NN
cord-295807-68sukdb1	567	27	by	by	IN
cord-295807-68sukdb1	567	28	stored	store	VBN
cord-295807-68sukdb1	567	29	cells	cell	NNS
cord-295807-68sukdb1	567	30	[	[	-LRB-
cord-295807-68sukdb1	567	31	364	364	CD
cord-295807-68sukdb1	567	32	,	,	,
cord-295807-68sukdb1	567	33	365	365	CD
cord-295807-68sukdb1	567	34	]	]	-RRB-
cord-295807-68sukdb1	567	35	.	.	.
cord-295807-68sukdb1	568	1	Finally	finally	RB
cord-295807-68sukdb1	568	2	,	,	,
cord-295807-68sukdb1	568	3	an	an	DT
cord-295807-68sukdb1	568	4	acidic	acidic	JJ
cord-295807-68sukdb1	568	5	tissue	tissue	NN
cord-295807-68sukdb1	568	6	environment	environment	NN
cord-295807-68sukdb1	568	7	appears	appear	VBZ
cord-295807-68sukdb1	568	8	to	to	TO
cord-295807-68sukdb1	568	9	favor	favor	VB
cord-295807-68sukdb1	568	10	natural	natural	JJ
cord-295807-68sukdb1	568	11	wound	wound	NN
cord-295807-68sukdb1	568	12	healing	healing	NN
cord-295807-68sukdb1	568	13	,	,	,
cord-295807-68sukdb1	568	14	yet	yet	CC
cord-295807-68sukdb1	568	15	alkaline	alkaline	JJ
cord-295807-68sukdb1	568	16	pH	pH	NNP
cord-295807-68sukdb1	568	17	favors	favor	VBZ
cord-295807-68sukdb1	568	18	the	the	DT
cord-295807-68sukdb1	568	19	success	success	NN
cord-295807-68sukdb1	568	20	of	of	IN
cord-295807-68sukdb1	568	21	skin	skin	NN
cord-295807-68sukdb1	568	22	grafts	graft	NNS
cord-295807-68sukdb1	568	23	[	[	-LRB-
cord-295807-68sukdb1	568	24	366	366	CD
cord-295807-68sukdb1	568	25	]	]	-RRB-
cord-295807-68sukdb1	568	26	.	.	.
cord-295807-68sukdb1	569	1	Altering	alter	VBG
cord-295807-68sukdb1	569	2	the	the	DT
cord-295807-68sukdb1	569	3	chemistry	chemistry	NN
cord-295807-68sukdb1	569	4	of	of	IN
cord-295807-68sukdb1	569	5	infused	infuse	VBN
cord-295807-68sukdb1	569	6	fluids	fluid	NNS
cord-295807-68sukdb1	569	7	is	be	VBZ
cord-295807-68sukdb1	569	8	the	the	DT
cord-295807-68sukdb1	569	9	obvious	obvious	JJ
cord-295807-68sukdb1	569	10	strategy	strategy	NN
cord-295807-68sukdb1	569	11	to	to	TO
cord-295807-68sukdb1	569	12	counter	counter	VB
cord-295807-68sukdb1	569	13	post	post	JJ
cord-295807-68sukdb1	569	14	-	-	JJ
cord-295807-68sukdb1	569	15	operative	operative	JJ
cord-295807-68sukdb1	569	16	acid	acid	NN
cord-295807-68sukdb1	569	17	-	-	HYPH
cord-295807-68sukdb1	569	18	base	base	NN
cord-295807-68sukdb1	569	19	disturbances	disturbance	NNS
cord-295807-68sukdb1	569	20	.	.	.
cord-295807-68sukdb1	570	1	With	with	IN
cord-295807-68sukdb1	570	2	specific	specific	JJ
cord-295807-68sukdb1	570	3	regard	regard	NN
cord-295807-68sukdb1	570	4	to	to	IN
cord-295807-68sukdb1	570	5	post	post	JJ
cord-295807-68sukdb1	570	6	-	-	JJ
cord-295807-68sukdb1	570	7	operative	operative	JJ
cord-295807-68sukdb1	570	8	MAc	MAc	NNP
cord-295807-68sukdb1	570	9	,	,	,
cord-295807-68sukdb1	570	10	dichloroacetate	dichloroacetate	NNP
cord-295807-68sukdb1	570	11	treatment	treatment	NN
cord-295807-68sukdb1	570	12	tempered	temper	VBD
cord-295807-68sukdb1	570	13	the	the	DT
cord-295807-68sukdb1	570	14	pathological	pathological	JJ
cord-295807-68sukdb1	570	15	rise	rise	NN
cord-295807-68sukdb1	570	16	in	in	IN
cord-295807-68sukdb1	570	17	lactate	lactate	NN
cord-295807-68sukdb1	570	18	following	follow	VBG
cord-295807-68sukdb1	570	19	liver	liver	NN
cord-295807-68sukdb1	570	20	transplantation	transplantation	NN
cord-295807-68sukdb1	570	21	,	,	,
cord-295807-68sukdb1	570	22	although	although	IN
cord-295807-68sukdb1	570	23	no	no	DT
cord-295807-68sukdb1	570	24	effect	effect	NN
cord-295807-68sukdb1	570	25	on	on	IN
cord-295807-68sukdb1	570	26	outcome	outcome	NN
cord-295807-68sukdb1	570	27	was	be	VBD
cord-295807-68sukdb1	570	28	observed	observe	VBN
cord-295807-68sukdb1	570	29	[	[	-LRB-
cord-295807-68sukdb1	570	30	367	367	CD
cord-295807-68sukdb1	570	31	]	]	-RRB-
cord-295807-68sukdb1	570	32	.	.	.
cord-295807-68sukdb1	571	1	Other	other	JJ
cord-295807-68sukdb1	571	2	treatments	treatment	NNS
cord-295807-68sukdb1	571	3	for	for	IN
cord-295807-68sukdb1	571	4	MAc	MAc	NNP
cord-295807-68sukdb1	571	5	are	be	VBP
cord-295807-68sukdb1	571	6	discussed	discuss	VBN
cord-295807-68sukdb1	571	7	in	in	IN
cord-295807-68sukdb1	571	8	section	section	NN
cord-295807-68sukdb1	571	9	3.2.2	3.2.2	NN
cord-295807-68sukdb1	571	10	.	.	.
cord-295807-68sukdb1	572	1	Treatment	treatment	NN
cord-295807-68sukdb1	572	2	for	for	IN
cord-295807-68sukdb1	572	3	MAlk	MAlk	NNS
cord-295807-68sukdb1	572	4	are	be	VBP
cord-295807-68sukdb1	572	5	discussed	discuss	VBN
cord-295807-68sukdb1	572	6	in	in	IN
cord-295807-68sukdb1	572	7	section	section	NN
cord-295807-68sukdb1	572	8	3.3.2	3.3.2	NN
cord-295807-68sukdb1	572	9	.	.	.
cord-295807-68sukdb1	573	1	Finally	finally	RB
cord-295807-68sukdb1	573	2	,	,	,
cord-295807-68sukdb1	573	3	a	a	DT
cord-295807-68sukdb1	573	4	study	study	NN
cord-295807-68sukdb1	573	5	in	in	IN
cord-295807-68sukdb1	573	6	mice	mouse	NNS
cord-295807-68sukdb1	573	7	suggests	suggest	VBZ
cord-295807-68sukdb1	573	8	that	that	IN
cord-295807-68sukdb1	573	9	raising	raise	VBG
cord-295807-68sukdb1	573	10	the	the	DT
cord-295807-68sukdb1	573	11	pH	ph	NN
cord-295807-68sukdb1	573	12	of	of	IN
cord-295807-68sukdb1	573	13	stored	store	VBN
cord-295807-68sukdb1	573	14	blood	blood	NN
cord-295807-68sukdb1	573	15	enhances	enhance	VBZ
cord-295807-68sukdb1	573	16	red	red	JJ
cord-295807-68sukdb1	573	17	blood	blood	NN
cord-295807-68sukdb1	573	18	survival	survival	NN
cord-295807-68sukdb1	573	19	after	after	IN
cord-295807-68sukdb1	573	20	transfusion	transfusion	NN
cord-295807-68sukdb1	573	21	[	[	-LRB-
cord-295807-68sukdb1	573	22	368	368	CD
cord-295807-68sukdb1	573	23	]	]	-RRB-
cord-295807-68sukdb1	573	24	.	.	.
cord-295807-68sukdb1	574	1	The	the	DT
cord-295807-68sukdb1	574	2	pH	ph	NN
cord-295807-68sukdb1	574	3	-	-	NN
cord-295807-68sukdb1	574	4	dependence	dependence	NN
cord-295807-68sukdb1	574	5	of	of	IN
cord-295807-68sukdb1	574	6	wound	wound	NN
cord-295807-68sukdb1	574	7	healing	healing	NN
cord-295807-68sukdb1	574	8	suggests	suggest	VBZ
cord-295807-68sukdb1	574	9	that	that	IN
cord-295807-68sukdb1	574	10	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	574	11	maintenance	maintenance	NN
cord-295807-68sukdb1	574	12	of	of	IN
cord-295807-68sukdb1	574	13	the	the	DT
cord-295807-68sukdb1	574	14	pH	ph	NN
cord-295807-68sukdb1	574	15	of	of	IN
cord-295807-68sukdb1	574	16	the	the	DT
cord-295807-68sukdb1	574	17	wound	wound	NN
cord-295807-68sukdb1	574	18	or	or	CC
cord-295807-68sukdb1	574	19	graft	graft	NN
cord-295807-68sukdb1	574	20	could	could	MD
cord-295807-68sukdb1	574	21	aid	aid	VB
cord-295807-68sukdb1	574	22	healing	heal	VBG
cord-295807-68sukdb1	574	23	[	[	-LRB-
cord-295807-68sukdb1	574	24	366	366	CD
cord-295807-68sukdb1	574	25	]	]	-RRB-
cord-295807-68sukdb1	574	26	.	.	.
cord-295807-68sukdb1	575	1	HCO3is	HCO3is	NNP
cord-295807-68sukdb1	575	2	a	a	DT
cord-295807-68sukdb1	575	3	major	major	JJ
cord-295807-68sukdb1	575	4	buffer	buffer	NN
cord-295807-68sukdb1	575	5	in	in	IN
cord-295807-68sukdb1	575	6	stimulated	stimulated	JJ
cord-295807-68sukdb1	575	7	saliva	saliva	NN
cord-295807-68sukdb1	575	8	[	[	-LRB-
cord-295807-68sukdb1	575	9	369	369	CD
cord-295807-68sukdb1	575	10	]	]	-RRB-
cord-295807-68sukdb1	575	11	,	,	,
cord-295807-68sukdb1	575	12	defending	defend	VBG
cord-295807-68sukdb1	575	13	oral	oral	JJ
cord-295807-68sukdb1	575	14	pH	ph	NN
cord-295807-68sukdb1	575	15	against	against	IN
cord-295807-68sukdb1	575	16	acidic	acidic	JJ
cord-295807-68sukdb1	575	17	foods	food	NNS
cord-295807-68sukdb1	575	18	and	and	CC
cord-295807-68sukdb1	575	19	drinks	drink	NNS
cord-295807-68sukdb1	575	20	and	and	CC
cord-295807-68sukdb1	575	21	against	against	IN
cord-295807-68sukdb1	575	22	those	those	DT
cord-295807-68sukdb1	575	23	acids	acid	NNS
cord-295807-68sukdb1	575	24	produced	produce	VBN
cord-295807-68sukdb1	575	25	from	from	IN
cord-295807-68sukdb1	575	26	sugars	sugar	NNS
cord-295807-68sukdb1	575	27	by	by	IN
cord-295807-68sukdb1	575	28	acidophilic	acidophilic	JJ
cord-295807-68sukdb1	575	29	bacteria	bacteria	NNS
cord-295807-68sukdb1	575	30	in	in	IN
cord-295807-68sukdb1	575	31	the	the	DT
cord-295807-68sukdb1	575	32	oral	oral	JJ
cord-295807-68sukdb1	575	33	cavity	cavity	NN
cord-295807-68sukdb1	575	34	.	.	.
cord-295807-68sukdb1	576	1	Acid	acid	NN
cord-295807-68sukdb1	576	2	defense	defense	NN
cord-295807-68sukdb1	576	3	protects	protect	VBZ
cord-295807-68sukdb1	576	4	enamel	enamel	NN
cord-295807-68sukdb1	576	5	from	from	IN
cord-295807-68sukdb1	576	6	erosion	erosion	NN
cord-295807-68sukdb1	576	7	and	and	CC
cord-295807-68sukdb1	576	8	oral	oral	JJ
cord-295807-68sukdb1	576	9	pH	ph	NN
cord-295807-68sukdb1	576	10	is	be	VBZ
cord-295807-68sukdb1	576	11	also	also	RB
cord-295807-68sukdb1	576	12	an	an	DT
cord-295807-68sukdb1	576	13	important	important	JJ
cord-295807-68sukdb1	576	14	determinant	determinant	NN
cord-295807-68sukdb1	576	15	of	of	IN
cord-295807-68sukdb1	576	16	a	a	DT
cord-295807-68sukdb1	576	17	healthy	healthy	JJ
cord-295807-68sukdb1	576	18	oral	oral	JJ
cord-295807-68sukdb1	576	19	microbiome	microbiome	NN
cord-295807-68sukdb1	576	20	;	;	:
cord-295807-68sukdb1	576	21	low	low	JJ
cord-295807-68sukdb1	576	22	salivary	salivary	NN
cord-295807-68sukdb1	576	23	flow	flow	NN
cord-295807-68sukdb1	576	24	and	and	CC
cord-295807-68sukdb1	577	1	pH	pH	NNP
cord-295807-68sukdb1	577	2	generally	generally	RB
cord-295807-68sukdb1	577	3	encourage	encourage	VBP
cord-295807-68sukdb1	577	4	the	the	DT
cord-295807-68sukdb1	577	5	presence	presence	NN
cord-295807-68sukdb1	577	6	of	of	IN
cord-295807-68sukdb1	577	7	pathogenic	pathogenic	JJ
cord-295807-68sukdb1	577	8	and	and	CC
cord-295807-68sukdb1	577	9	cariogenic	cariogenic	JJ
cord-295807-68sukdb1	577	10	bacteria	bacteria	NNS
cord-295807-68sukdb1	577	11	(	(	-LRB-
cord-295807-68sukdb1	577	12	e.g.	e.g.	RB
cord-295807-68sukdb1	577	13	,	,	,
cord-295807-68sukdb1	577	14	[	[	-LRB-
cord-295807-68sukdb1	577	15	370	370	CD
cord-295807-68sukdb1	577	16	,	,	,
cord-295807-68sukdb1	577	17	371	371	CD
cord-295807-68sukdb1	577	18	]	]	-RRB-
cord-295807-68sukdb1	577	19	)	)	-RRB-
cord-295807-68sukdb1	577	20	.	.	.
cord-295807-68sukdb1	578	1	As	as	IN
cord-295807-68sukdb1	578	2	a	a	DT
cord-295807-68sukdb1	578	3	consequence	consequence	NN
cord-295807-68sukdb1	578	4	,	,	,
cord-295807-68sukdb1	578	5	low	low	JJ
cord-295807-68sukdb1	578	6	salivary	salivary	NN
cord-295807-68sukdb1	578	7	pH	ph	NN
cord-295807-68sukdb1	578	8	,	,	,
cord-295807-68sukdb1	578	9	[	[	-LRB-
cord-295807-68sukdb1	578	10	HCO3	HCO3	NNP
cord-295807-68sukdb1	578	11	-	-	HYPH
cord-295807-68sukdb1	578	12	]	]	-RRB-
cord-295807-68sukdb1	578	13	,	,	,
cord-295807-68sukdb1	578	14	and/or	and/or	CC
cord-295807-68sukdb1	578	15	buffer	buffer	NN
cord-295807-68sukdb1	578	16	capacity	capacity	NN
cord-295807-68sukdb1	578	17	are	be	VBP
cord-295807-68sukdb1	578	18	predictors	predictor	NNS
cord-295807-68sukdb1	578	19	of	of	IN
cord-295807-68sukdb1	578	20	cavity	cavity	NN
cord-295807-68sukdb1	578	21	formation	formation	NN
cord-295807-68sukdb1	578	22	[	[	-LRB-
cord-295807-68sukdb1	578	23	372	372	CD
cord-295807-68sukdb1	578	24	]	]	-RRB-
cord-295807-68sukdb1	578	25	[	[	-LRB-
cord-295807-68sukdb1	578	26	373	373	CD
cord-295807-68sukdb1	578	27	]	]	-RRB-
cord-295807-68sukdb1	578	28	[	[	-LRB-
cord-295807-68sukdb1	578	29	374	374	CD
cord-295807-68sukdb1	578	30	]	]	-RRB-
cord-295807-68sukdb1	578	31	.	.	.
cord-295807-68sukdb1	579	1	Salivary	salivary	NN
cord-295807-68sukdb1	579	2	pH	pH	NNP
cord-295807-68sukdb1	579	3	is	be	VBZ
cord-295807-68sukdb1	579	4	lowered	lower	VBN
cord-295807-68sukdb1	579	5	in	in	IN
cord-295807-68sukdb1	579	6	many	many	JJ
cord-295807-68sukdb1	579	7	groups	group	NNS
cord-295807-68sukdb1	579	8	of	of	IN
cord-295807-68sukdb1	579	9	individuals	individual	NNS
cord-295807-68sukdb1	579	10	such	such	JJ
cord-295807-68sukdb1	579	11	as	as	IN
cord-295807-68sukdb1	579	12	patients	patient	NNS
cord-295807-68sukdb1	579	13	undergoing	undergo	VBG
cord-295807-68sukdb1	579	14	chemotherapy	chemotherapy	NN
cord-295807-68sukdb1	579	15	for	for	IN
cord-295807-68sukdb1	579	16	head	head	NN
cord-295807-68sukdb1	579	17	/	/	SYM
cord-295807-68sukdb1	579	18	neck	neck	NN
cord-295807-68sukdb1	579	19	cancer	cancer	NN
cord-295807-68sukdb1	579	20	[	[	-LRB-
cord-295807-68sukdb1	579	21	370	370	CD
cord-295807-68sukdb1	579	22	]	]	-RRB-
cord-295807-68sukdb1	579	23	,	,	,
cord-295807-68sukdb1	579	24	cocaine	cocaine	NN
cord-295807-68sukdb1	579	25	users	user	NNS
cord-295807-68sukdb1	579	26	[	[	-LRB-
cord-295807-68sukdb1	579	27	375	375	CD
cord-295807-68sukdb1	579	28	]	]	-RRB-
cord-295807-68sukdb1	579	29	,	,	,
cord-295807-68sukdb1	579	30	or	or	CC
cord-295807-68sukdb1	579	31	tobacco	tobacco	NN
cord-295807-68sukdb1	579	32	smokers	smoker	NNS
cord-295807-68sukdb1	579	33	[	[	-LRB-
cord-295807-68sukdb1	579	34	376	376	CD
cord-295807-68sukdb1	579	35	]	]	-RRB-
cord-295807-68sukdb1	579	36	.	.	.
cord-295807-68sukdb1	580	1	Low	low	JJ
cord-295807-68sukdb1	580	2	salivary	salivary	NN
cord-295807-68sukdb1	580	3	pH	ph	NN
cord-295807-68sukdb1	580	4	is	be	VBZ
cord-295807-68sukdb1	580	5	also	also	RB
cord-295807-68sukdb1	580	6	described	describe	VBN
cord-295807-68sukdb1	580	7	in	in	IN
cord-295807-68sukdb1	580	8	individuals	individual	NNS
cord-295807-68sukdb1	580	9	with	with	IN
cord-295807-68sukdb1	580	10	diseases	disease	NNS
cord-295807-68sukdb1	580	11	such	such	JJ
cord-295807-68sukdb1	580	12	as	as	IN
cord-295807-68sukdb1	580	13	CF	CF	NNP
cord-295807-68sukdb1	580	14	[	[	-LRB-
cord-295807-68sukdb1	580	15	377	377	CD
cord-295807-68sukdb1	580	16	]	]	-RRB-
cord-295807-68sukdb1	580	17	,	,	,
cord-295807-68sukdb1	580	18	Sjögren	Sjögren	NNP
cord-295807-68sukdb1	580	19	's	's	POS
cord-295807-68sukdb1	580	20	syndrome	syndrome	NN
cord-295807-68sukdb1	580	21	[	[	-LRB-
cord-295807-68sukdb1	580	22	378	378	CD
cord-295807-68sukdb1	580	23	]	]	-RRB-
cord-295807-68sukdb1	580	24	,	,	,
cord-295807-68sukdb1	580	25	and	and	CC
cord-295807-68sukdb1	580	26	juvenile	juvenile	JJ
cord-295807-68sukdb1	580	27	idiopathic	idiopathic	JJ
cord-295807-68sukdb1	580	28	arthritis	arthritis	NN
cord-295807-68sukdb1	580	29	[	[	-LRB-
cord-295807-68sukdb1	580	30	379	379	CD
cord-295807-68sukdb1	580	31	]	]	-RRB-
cord-295807-68sukdb1	580	32	.	.	.
cord-295807-68sukdb1	581	1	Not	not	RB
cord-295807-68sukdb1	581	2	all	all	DT
cord-295807-68sukdb1	581	3	studies	study	NNS
cord-295807-68sukdb1	581	4	report	report	VBP
cord-295807-68sukdb1	581	5	a	a	DT
cord-295807-68sukdb1	581	6	major	major	JJ
cord-295807-68sukdb1	581	7	impact	impact	NN
cord-295807-68sukdb1	581	8	on	on	IN
cord-295807-68sukdb1	581	9	dental	dental	JJ
cord-295807-68sukdb1	581	10	health	health	NN
cord-295807-68sukdb1	581	11	in	in	IN
cord-295807-68sukdb1	581	12	these	these	DT
cord-295807-68sukdb1	581	13	cases	case	NNS
cord-295807-68sukdb1	581	14	as	as	IN
cord-295807-68sukdb1	581	15	compensating	compensate	VBG
cord-295807-68sukdb1	581	16	factors	factor	NNS
cord-295807-68sukdb1	581	17	may	may	MD
cord-295807-68sukdb1	581	18	be	be	VB
cord-295807-68sukdb1	581	19	in	in	IN
cord-295807-68sukdb1	581	20	play	play	NN
cord-295807-68sukdb1	581	21	[	[	-LRB-
cord-295807-68sukdb1	581	22	379	379	CD
cord-295807-68sukdb1	581	23	]	]	-RRB-
cord-295807-68sukdb1	581	24	.	.	.
cord-295807-68sukdb1	582	1	ABTs	ABTs	NNP
cord-295807-68sukdb1	582	2	and	and	CC
cord-295807-68sukdb1	582	3	CAs	CAs	NNP
cord-295807-68sukdb1	582	4	play	play	VBP
cord-295807-68sukdb1	582	5	important	important	JJ
cord-295807-68sukdb1	582	6	roles	role	NNS
cord-295807-68sukdb1	582	7	in	in	IN
cord-295807-68sukdb1	582	8	salivary	salivary	JJ
cord-295807-68sukdb1	582	9	secretion	secretion	NN
cord-295807-68sukdb1	582	10	and	and	CC
cord-295807-68sukdb1	582	11	well	well	RB
cord-295807-68sukdb1	582	12	as	as	IN
cord-295807-68sukdb1	582	13	in	in	IN
cord-295807-68sukdb1	582	14	enamel	enamel	JJ
cord-295807-68sukdb1	582	15	formation	formation	NN
cord-295807-68sukdb1	582	16	[	[	-LRB-
cord-295807-68sukdb1	582	17	312	312	CD
cord-295807-68sukdb1	582	18	,	,	,
cord-295807-68sukdb1	582	19	380	380	CD
cord-295807-68sukdb1	582	20	]	]	-RRB-
cord-295807-68sukdb1	582	21	.	.	.
cord-295807-68sukdb1	583	1	For	for	IN
cord-295807-68sukdb1	583	2	example	example	NN
cord-295807-68sukdb1	583	3	,	,	,
cord-295807-68sukdb1	583	4	defective	defective	JJ
cord-295807-68sukdb1	583	5	dentition	dentition	NN
cord-295807-68sukdb1	583	6	is	be	VBZ
cord-295807-68sukdb1	583	7	a	a	DT
cord-295807-68sukdb1	583	8	feature	feature	NN
cord-295807-68sukdb1	583	9	of	of	IN
cord-295807-68sukdb1	583	10	some	some	DT
cord-295807-68sukdb1	583	11	individuals	individual	NNS
cord-295807-68sukdb1	583	12	with	with	IN
cord-295807-68sukdb1	583	13	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	583	14	mutations	mutation	NNS
cord-295807-68sukdb1	583	15	[	[	-LRB-
cord-295807-68sukdb1	583	16	381	381	CD
cord-295807-68sukdb1	583	17	]	]	-RRB-
cord-295807-68sukdb1	583	18	and	and	CC
cord-295807-68sukdb1	583	19	appears	appear	VBZ
cord-295807-68sukdb1	583	20	not	not	RB
cord-295807-68sukdb1	583	21	to	to	TO
cord-295807-68sukdb1	583	22	be	be	VB
cord-295807-68sukdb1	583	23	a	a	DT
cord-295807-68sukdb1	583	24	secondary	secondary	JJ
cord-295807-68sukdb1	583	25	consequence	consequence	NN
cord-295807-68sukdb1	583	26	of	of	IN
cord-295807-68sukdb1	583	27	acidemia	acidemia	NN
cord-295807-68sukdb1	583	28	[	[	-LRB-
cord-295807-68sukdb1	583	29	382	382	CD
cord-295807-68sukdb1	583	30	]	]	-RRB-
cord-295807-68sukdb1	583	31	.	.	.
cord-295807-68sukdb1	584	1	Salivary	salivary	NN
cord-295807-68sukdb1	584	2	pH	ph	NN
cord-295807-68sukdb1	584	3	is	be	VBZ
cord-295807-68sukdb1	584	4	a	a	DT
cord-295807-68sukdb1	584	5	useful	useful	JJ
cord-295807-68sukdb1	584	6	biomarker	biomarker	NN
cord-295807-68sukdb1	584	7	for	for	IN
cord-295807-68sukdb1	584	8	oral	oral	JJ
cord-295807-68sukdb1	584	9	health	health	NN
cord-295807-68sukdb1	584	10	[	[	-LRB-
cord-295807-68sukdb1	584	11	383	383	CD
cord-295807-68sukdb1	584	12	]	]	-RRB-
cord-295807-68sukdb1	584	13	and	and	CC
cord-295807-68sukdb1	584	14	the	the	DT
cord-295807-68sukdb1	584	15	usefulness	usefulness	NN
cord-295807-68sukdb1	584	16	of	of	IN
cord-295807-68sukdb1	584	17	baking	bake	VBG
cord-295807-68sukdb1	584	18	soda	soda	NN
cord-295807-68sukdb1	584	19	in	in	IN
cord-295807-68sukdb1	584	20	oral	oral	JJ
cord-295807-68sukdb1	584	21	hygiene	hygiene	NN
cord-295807-68sukdb1	584	22	was	be	VBD
cord-295807-68sukdb1	584	23	first	first	RB
cord-295807-68sukdb1	584	24	suggested	suggest	VBN
cord-295807-68sukdb1	584	25	as	as	RB
cord-295807-68sukdb1	584	26	long	long	RB
cord-295807-68sukdb1	584	27	ago	ago	RB
cord-295807-68sukdb1	584	28	as	as	IN
cord-295807-68sukdb1	584	29	1911	1911	CD
cord-295807-68sukdb1	584	30	[	[	-LRB-
cord-295807-68sukdb1	584	31	384	384	CD
cord-295807-68sukdb1	584	32	]	]	-RRB-
cord-295807-68sukdb1	584	33	.	.	.
cord-295807-68sukdb1	585	1	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	585	2	delivery	delivery	NN
cord-295807-68sukdb1	585	3	either	either	CC
cord-295807-68sukdb1	585	4	as	as	IN
cord-295807-68sukdb1	585	5	a	a	DT
cord-295807-68sukdb1	585	6	mouth	mouth	NN
cord-295807-68sukdb1	585	7	wash	wash	NN
cord-295807-68sukdb1	585	8	[	[	-LRB-
cord-295807-68sukdb1	585	9	385	385	CD
cord-295807-68sukdb1	585	10	]	]	-RRB-
cord-295807-68sukdb1	585	11	,	,	,
cord-295807-68sukdb1	585	12	mucoadhesive	mucoadhesive	NNP
cord-295807-68sukdb1	585	13	spray	spray	NN
cord-295807-68sukdb1	585	14	[	[	-LRB-
cord-295807-68sukdb1	585	15	386	386	CD
cord-295807-68sukdb1	585	16	]	]	-RRB-
cord-295807-68sukdb1	585	17	or	or	CC
cord-295807-68sukdb1	585	18	sugar	sugar	NN
cord-295807-68sukdb1	585	19	-	-	HYPH
cord-295807-68sukdb1	585	20	free	free	JJ
cord-295807-68sukdb1	585	21	gum	gum	NN
cord-295807-68sukdb1	585	22	[	[	-LRB-
cord-295807-68sukdb1	585	23	387	387	CD
cord-295807-68sukdb1	585	24	]	]	-RRB-
cord-295807-68sukdb1	585	25	raises	raise	VBZ
cord-295807-68sukdb1	585	26	salivary	salivary	NN
cord-295807-68sukdb1	585	27	pH	ph	NN
cord-295807-68sukdb1	585	28	and	and	CC
cord-295807-68sukdb1	585	29	in	in	IN
cord-295807-68sukdb1	585	30	some	some	DT
cord-295807-68sukdb1	585	31	cases	case	NNS
cord-295807-68sukdb1	585	32	may	may	MD
cord-295807-68sukdb1	585	33	lower	lower	VB
cord-295807-68sukdb1	585	34	colonization	colonization	NN
cord-295807-68sukdb1	585	35	of	of	IN
cord-295807-68sukdb1	585	36	acidophilic	acidophilic	JJ
cord-295807-68sukdb1	585	37	bacteria	bacteria	NNS
cord-295807-68sukdb1	585	38	.	.	.
cord-295807-68sukdb1	586	1	In	in	IN
cord-295807-68sukdb1	586	2	individuals	individual	NNS
cord-295807-68sukdb1	586	3	undergoing	undergo	VBG
cord-295807-68sukdb1	586	4	chemotherapy	chemotherapy	NN
cord-295807-68sukdb1	586	5	for	for	IN
cord-295807-68sukdb1	586	6	leukemia	leukemia	NN
cord-295807-68sukdb1	586	7	,	,	,
cord-295807-68sukdb1	586	8	use	use	NN
cord-295807-68sukdb1	586	9	of	of	IN
cord-295807-68sukdb1	586	10	a	a	DT
cord-295807-68sukdb1	586	11	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	586	12	mouthwash	mouthwash	NN
cord-295807-68sukdb1	586	13	lowered	lower	VBD
cord-295807-68sukdb1	586	14	susceptibility	susceptibility	NN
cord-295807-68sukdb1	586	15	to	to	IN
cord-295807-68sukdb1	586	16	mouth	mouth	NN
cord-295807-68sukdb1	586	17	ulcers	ulcer	NNS
cord-295807-68sukdb1	586	18	[	[	-LRB-
cord-295807-68sukdb1	586	19	388	388	CD
cord-295807-68sukdb1	586	20	]	]	-RRB-
cord-295807-68sukdb1	586	21	.	.	.
cord-295807-68sukdb1	587	1	In	in	IN
cord-295807-68sukdb1	587	2	smokers	smoker	NNS
cord-295807-68sukdb1	587	3	the	the	DT
cord-295807-68sukdb1	587	4	similar	similar	JJ
cord-295807-68sukdb1	587	5	treatment	treatment	NN
cord-295807-68sukdb1	587	6	reduced	reduce	VBN
cord-295807-68sukdb1	587	7	levels	level	NNS
cord-295807-68sukdb1	587	8	of	of	IN
cord-295807-68sukdb1	587	9	the	the	DT
cord-295807-68sukdb1	587	10	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	587	11	biomarker	biomarker	NN
cord-295807-68sukdb1	587	12	IL-1β	il-1β	NN
cord-295807-68sukdb1	587	13	[	[	-LRB-
cord-295807-68sukdb1	587	14	376	376	CD
cord-295807-68sukdb1	587	15	]	]	-RRB-
cord-295807-68sukdb1	587	16	.	.	.
cord-295807-68sukdb1	588	1	NaHCO3containing	nahco3containe	VBG
cord-295807-68sukdb1	589	1	dentifrices	dentifrice	NNS
cord-295807-68sukdb1	589	2	have	have	VBP
cord-295807-68sukdb1	589	3	been	be	VBN
cord-295807-68sukdb1	589	4	shown	show	VBN
cord-295807-68sukdb1	589	5	to	to	TO
cord-295807-68sukdb1	589	6	be	be	VB
cord-295807-68sukdb1	589	7	effective	effective	JJ
cord-295807-68sukdb1	589	8	at	at	IN
cord-295807-68sukdb1	589	9	neutralizing	neutralize	VBG
cord-295807-68sukdb1	589	10	plaque	plaque	NN
cord-295807-68sukdb1	590	1	pH	pH	NNP
cord-295807-68sukdb1	590	2	[	[	-LRB-
cord-295807-68sukdb1	590	3	389	389	CD
cord-295807-68sukdb1	590	4	]	]	-RRB-
cord-295807-68sukdb1	590	5	,	,	,
cord-295807-68sukdb1	590	6	enhancing	enhance	VBG
cord-295807-68sukdb1	590	7	plaque	plaque	NN
cord-295807-68sukdb1	590	8	removal	removal	NN
cord-295807-68sukdb1	590	9	[	[	-LRB-
cord-295807-68sukdb1	590	10	390	390	CD
cord-295807-68sukdb1	590	11	]	]	-RRB-
cord-295807-68sukdb1	590	12	,	,	,
cord-295807-68sukdb1	590	13	and	and	CC
cord-295807-68sukdb1	590	14	inhibiting	inhibit	VBG
cord-295807-68sukdb1	590	15	formation	formation	NN
cord-295807-68sukdb1	590	16	of	of	IN
cord-295807-68sukdb1	590	17	caries	caries	NN
cord-295807-68sukdb1	590	18	[	[	-LRB-
cord-295807-68sukdb1	590	19	391	391	CD
cord-295807-68sukdb1	590	20	]	]	-RRB-
cord-295807-68sukdb1	590	21	.	.	.
cord-295807-68sukdb1	591	1	pH	ph	NN
cord-295807-68sukdb1	591	2	-	-	HYPH
cord-295807-68sukdb1	591	3	stabilizing	stabilize	VBG
cord-295807-68sukdb1	591	4	resins	resin	NNS
cord-295807-68sukdb1	591	5	used	use	VBN
cord-295807-68sukdb1	591	6	in	in	IN
cord-295807-68sukdb1	591	7	restorative	restorative	JJ
cord-295807-68sukdb1	591	8	dentistry	dentistry	NN
cord-295807-68sukdb1	591	9	have	have	VBP
cord-295807-68sukdb1	591	10	also	also	RB
cord-295807-68sukdb1	591	11	been	be	VBN
cord-295807-68sukdb1	591	12	suggested	suggest	VBN
cord-295807-68sukdb1	591	13	to	to	TO
cord-295807-68sukdb1	591	14	be	be	VB
cord-295807-68sukdb1	591	15	useful	useful	JJ
cord-295807-68sukdb1	591	16	cariostatic	cariostatic	NN
cord-295807-68sukdb1	591	17	by	by	IN
cord-295807-68sukdb1	591	18	releasing	release	VBG
cord-295807-68sukdb1	591	19	OH	OH	NNP
cord-295807-68sukdb1	591	20	-	-	:
cord-295807-68sukdb1	591	21	[	[	-LRB-
cord-295807-68sukdb1	591	22	392	392	CD
cord-295807-68sukdb1	591	23	]	]	-RRB-
cord-295807-68sukdb1	591	24	.	.	.
cord-295807-68sukdb1	592	1	Finally	finally	RB
cord-295807-68sukdb1	592	2	,	,	,
cord-295807-68sukdb1	592	3	reducing	reduce	VBG
cord-295807-68sukdb1	592	4	dietary	dietary	JJ
cord-295807-68sukdb1	592	5	intake	intake	NN
cord-295807-68sukdb1	592	6	of	of	IN
cord-295807-68sukdb1	592	7	sugars	sugar	NNS
cord-295807-68sukdb1	592	8	is	be	VBZ
cord-295807-68sukdb1	592	9	also	also	RB
cord-295807-68sukdb1	592	10	beneficial	beneficial	JJ
cord-295807-68sukdb1	592	11	to	to	IN
cord-295807-68sukdb1	592	12	oral	oral	JJ
cord-295807-68sukdb1	592	13	pH	ph	NN
cord-295807-68sukdb1	592	14	because	because	IN
cord-295807-68sukdb1	592	15	it	-PRON-	PRP
cord-295807-68sukdb1	592	16	limits	limit	VBZ
cord-295807-68sukdb1	592	17	the	the	DT
cord-295807-68sukdb1	592	18	acidification	acidification	NN
cord-295807-68sukdb1	592	19	that	that	WDT
cord-295807-68sukdb1	592	20	can	can	MD
cord-295807-68sukdb1	592	21	be	be	VB
cord-295807-68sukdb1	592	22	caused	cause	VBN
cord-295807-68sukdb1	592	23	by	by	IN
cord-295807-68sukdb1	592	24	acidophilic	acidophilic	JJ
cord-295807-68sukdb1	592	25	bacteria	bacteria	NNS
cord-295807-68sukdb1	592	26	.	.	.
cord-295807-68sukdb1	593	1	Hence	hence	RB
cord-295807-68sukdb1	593	2	sugar	sugar	NN
cord-295807-68sukdb1	593	3	-	-	HYPH
cord-295807-68sukdb1	593	4	free	free	JJ
cord-295807-68sukdb1	593	5	gum	gum	NN
cord-295807-68sukdb1	593	6	is	be	VBZ
cord-295807-68sukdb1	593	7	effective	effective	JJ
cord-295807-68sukdb1	593	8	at	at	IN
cord-295807-68sukdb1	593	9	raising	raise	VBG
cord-295807-68sukdb1	593	10	plaque	plaque	NN
cord-295807-68sukdb1	593	11	pH	ph	NN
cord-295807-68sukdb1	593	12	[	[	-LRB-
cord-295807-68sukdb1	593	13	393	393	CD
cord-295807-68sukdb1	593	14	]	]	-RRB-
cord-295807-68sukdb1	593	15	.	.	.
cord-295807-68sukdb1	594	1	We	-PRON-	PRP
cord-295807-68sukdb1	594	2	have	have	VBP
cord-295807-68sukdb1	594	3	dealt	deal	VBN
cord-295807-68sukdb1	594	4	with	with	IN
cord-295807-68sukdb1	594	5	various	various	JJ
cord-295807-68sukdb1	594	6	aspects	aspect	NNS
cord-295807-68sukdb1	594	7	of	of	IN
cord-295807-68sukdb1	594	8	acid	acid	NN
cord-295807-68sukdb1	594	9	-	-	HYPH
cord-295807-68sukdb1	594	10	base	base	NN
cord-295807-68sukdb1	594	11	-	-	HYPH
cord-295807-68sukdb1	594	12	related	relate	VBN
cord-295807-68sukdb1	594	13	medical	medical	JJ
cord-295807-68sukdb1	594	14	microbiology	microbiology	NN
cord-295807-68sukdb1	594	15	in	in	IN
cord-295807-68sukdb1	594	16	earlier	early	JJR
cord-295807-68sukdb1	594	17	sections	section	NNS
cord-295807-68sukdb1	594	18	(	(	-LRB-
cord-295807-68sukdb1	594	19	see	see	VB
cord-295807-68sukdb1	594	20	sections	section	NNS
cord-295807-68sukdb1	594	21	on	on	IN
cord-295807-68sukdb1	594	22	The	the	DT
cord-295807-68sukdb1	594	23	Respiratory	Respiratory	NNP
cord-295807-68sukdb1	594	24	System	System	NNP
cord-295807-68sukdb1	594	25	,	,	,
cord-295807-68sukdb1	594	26	The	the	DT
cord-295807-68sukdb1	594	27	Upper	Upper	NNP
cord-295807-68sukdb1	594	28	Digestive	Digestive	NNP
cord-295807-68sukdb1	594	29	System	System	NNP
cord-295807-68sukdb1	594	30	,	,	,
cord-295807-68sukdb1	594	31	The	the	DT
cord-295807-68sukdb1	594	32	Lower	Lower	NNP
cord-295807-68sukdb1	594	33	Digestive	Digestive	NNP
cord-295807-68sukdb1	594	34	System	System	NNP
cord-295807-68sukdb1	594	35	,	,	,
cord-295807-68sukdb1	594	36	The	the	DT
cord-295807-68sukdb1	594	37	Reproductive	Reproductive	NNP
cord-295807-68sukdb1	594	38	System	System	NNP
cord-295807-68sukdb1	594	39	,	,	,
cord-295807-68sukdb1	594	40	The	the	DT
cord-295807-68sukdb1	594	41	Immune	Immune	NNP
cord-295807-68sukdb1	594	42	System	System	NNP
cord-295807-68sukdb1	594	43	and	and	CC
cord-295807-68sukdb1	594	44	Oral	Oral	NNP
cord-295807-68sukdb1	594	45	Health	Health	NNP
cord-295807-68sukdb1	594	46	)	)	-RRB-
cord-295807-68sukdb1	594	47	.	.	.
cord-295807-68sukdb1	595	1	In	in	IN
cord-295807-68sukdb1	595	2	this	this	DT
cord-295807-68sukdb1	595	3	section	section	NN
cord-295807-68sukdb1	595	4	we	-PRON-	PRP
cord-295807-68sukdb1	595	5	will	will	MD
cord-295807-68sukdb1	595	6	confine	confine	VB
cord-295807-68sukdb1	595	7	our	-PRON-	PRP$
cord-295807-68sukdb1	595	8	considerations	consideration	NNS
cord-295807-68sukdb1	595	9	to	to	IN
cord-295807-68sukdb1	595	10	viruses	virus	NNS
cord-295807-68sukdb1	595	11	and	and	CC
cord-295807-68sukdb1	595	12	parasites	parasite	NNS
cord-295807-68sukdb1	595	13	,	,	,
cord-295807-68sukdb1	595	14	using	use	VBG
cord-295807-68sukdb1	595	15	influenza	influenza	NN
cord-295807-68sukdb1	595	16	and	and	CC
cord-295807-68sukdb1	595	17	malaria	malaria	NN
cord-295807-68sukdb1	595	18	as	as	IN
cord-295807-68sukdb1	595	19	examples	example	NNS
cord-295807-68sukdb1	595	20	.	.	.
cord-295807-68sukdb1	595	21	.	.	.
cord-295807-68sukdb1	596	1	Both	both	DT
cord-295807-68sukdb1	596	2	of	of	IN
cord-295807-68sukdb1	596	3	these	these	DT
cord-295807-68sukdb1	596	4	mechanisms	mechanism	NNS
cord-295807-68sukdb1	596	5	are	be	VBP
cord-295807-68sukdb1	596	6	necessary	necessary	JJ
cord-295807-68sukdb1	596	7	to	to	TO
cord-295807-68sukdb1	596	8	support	support	VB
cord-295807-68sukdb1	596	9	viral	viral	JJ
cord-295807-68sukdb1	596	10	replication	replication	NN
cord-295807-68sukdb1	596	11	.	.	.
cord-295807-68sukdb1	597	1	In	in	IN
cord-295807-68sukdb1	597	2	defending	defend	VBG
cord-295807-68sukdb1	597	3	pHi	pHi	NNS
cord-295807-68sukdb1	597	4	against	against	IN
cord-295807-68sukdb1	597	5	the	the	DT
cord-295807-68sukdb1	597	6	increased	increase	VBN
cord-295807-68sukdb1	597	7	acid	acid	NN
cord-295807-68sukdb1	597	8	load	load	NN
cord-295807-68sukdb1	597	9	,	,	,
cord-295807-68sukdb1	597	10	infected	infected	JJ
cord-295807-68sukdb1	597	11	cells	cell	NNS
cord-295807-68sukdb1	597	12	extrude	extrude	VBP
cord-295807-68sukdb1	597	13	H	h	NN
cord-295807-68sukdb1	597	14	+	+	CC
cord-295807-68sukdb1	597	15	,	,	,
cord-295807-68sukdb1	597	16	creating	create	VBG
cord-295807-68sukdb1	597	17	a	a	DT
cord-295807-68sukdb1	597	18	concomitant	concomitant	JJ
cord-295807-68sukdb1	597	19	acidification	acidification	NN
cord-295807-68sukdb1	597	20	of	of	IN
cord-295807-68sukdb1	597	21	pHe	phe	NN
cord-295807-68sukdb1	597	22	at	at	IN
cord-295807-68sukdb1	597	23	the	the	DT
cord-295807-68sukdb1	597	24	cell	cell	NN
cord-295807-68sukdb1	597	25	surface	surface	NN
cord-295807-68sukdb1	597	26	[	[	-LRB-
cord-295807-68sukdb1	597	27	394	394	CD
cord-295807-68sukdb1	597	28	]	]	-RRB-
cord-295807-68sukdb1	597	29	.	.	.
cord-295807-68sukdb1	598	1	There	there	EX
cord-295807-68sukdb1	598	2	are	be	VBP
cord-295807-68sukdb1	598	3	multiple	multiple	JJ
cord-295807-68sukdb1	598	4	acid	acid	NN
cord-295807-68sukdb1	598	5	-	-	HYPH
cord-295807-68sukdb1	598	6	base	base	NN
cord-295807-68sukdb1	598	7	-	-	HYPH
cord-295807-68sukdb1	598	8	related	relate	VBN
cord-295807-68sukdb1	598	9	aspects	aspect	NNS
cord-295807-68sukdb1	598	10	to	to	IN
cord-295807-68sukdb1	598	11	the	the	DT
cord-295807-68sukdb1	598	12	malarial	malarial	JJ
cord-295807-68sukdb1	598	13	lifecycle	lifecycle	NN
cord-295807-68sukdb1	598	14	and	and	CC
cord-295807-68sukdb1	598	15	its	-PRON-	PRP$
cord-295807-68sukdb1	598	16	pathological	pathological	JJ
cord-295807-68sukdb1	598	17	impact	impact	NN
cord-295807-68sukdb1	598	18	.	.	.
cord-295807-68sukdb1	599	1	First	first	RB
cord-295807-68sukdb1	599	2	of	of	IN
cord-295807-68sukdb1	599	3	all	all	DT
cord-295807-68sukdb1	599	4	,	,	,
cord-295807-68sukdb1	599	5	mosquitos	mosquito	NNS
cord-295807-68sukdb1	599	6	are	be	VBP
cord-295807-68sukdb1	599	7	attracted	attract	VBN
cord-295807-68sukdb1	599	8	by	by	IN
cord-295807-68sukdb1	599	9	CO2	CO2	NNP
cord-295807-68sukdb1	599	10	and	and	CC
cord-295807-68sukdb1	599	11	CO2	CO2	NNP
cord-295807-68sukdb1	599	12	sensitizes	sensitize	VBZ
cord-295807-68sukdb1	599	13	them	-PRON-	PRP
cord-295807-68sukdb1	599	14	to	to	IN
cord-295807-68sukdb1	599	15	human	human	JJ
cord-295807-68sukdb1	599	16	odors	odor	NNS
cord-295807-68sukdb1	599	17	[	[	-LRB-
cord-295807-68sukdb1	599	18	395	395	CD
cord-295807-68sukdb1	599	19	]	]	-RRB-
cord-295807-68sukdb1	599	20	.	.	.
cord-295807-68sukdb1	600	1	Secondly	secondly	RB
cord-295807-68sukdb1	600	2	,	,	,
cord-295807-68sukdb1	600	3	the	the	DT
cord-295807-68sukdb1	600	4	erythrocytic	erythrocytic	JJ
cord-295807-68sukdb1	600	5	phase	phase	NN
cord-295807-68sukdb1	600	6	of	of	IN
cord-295807-68sukdb1	600	7	malaria	malaria	NN
cord-295807-68sukdb1	600	8	infection	infection	NN
cord-295807-68sukdb1	600	9	requires	require	VBZ
cord-295807-68sukdb1	600	10	that	that	IN
cord-295807-68sukdb1	600	11	Plasmodium	Plasmodium	NNP
cord-295807-68sukdb1	600	12	invades	invade	VBZ
cord-295807-68sukdb1	600	13	red	red	JJ
cord-295807-68sukdb1	600	14	blood	blood	NN
cord-295807-68sukdb1	600	15	cells	cell	NNS
cord-295807-68sukdb1	600	16	.	.	.
cord-295807-68sukdb1	601	1	One	one	CD
cord-295807-68sukdb1	601	2	of	of	IN
cord-295807-68sukdb1	601	3	the	the	DT
cord-295807-68sukdb1	601	4	surface	surface	NN
cord-295807-68sukdb1	601	5	antigens	antigen	NNS
cord-295807-68sukdb1	601	6	that	that	WDT
cord-295807-68sukdb1	601	7	Plasmodium	Plasmodium	NNP
cord-295807-68sukdb1	601	8	exploits	exploit	VBZ
cord-295807-68sukdb1	601	9	for	for	IN
cord-295807-68sukdb1	601	10	host	host	NN
cord-295807-68sukdb1	601	11	-	-	HYPH
cord-295807-68sukdb1	601	12	cell	cell	NN
cord-295807-68sukdb1	601	13	recognition	recognition	NN
cord-295807-68sukdb1	601	14	and	and	CC
cord-295807-68sukdb1	601	15	invasion	invasion	NN
cord-295807-68sukdb1	601	16	is	be	VBZ
cord-295807-68sukdb1	601	17	the	the	DT
cord-295807-68sukdb1	601	18	AE1-glycophorin	ae1-glycophorin	NN
cord-295807-68sukdb1	601	19	A	a	DT
cord-295807-68sukdb1	601	20	complex	complex	NN
cord-295807-68sukdb1	601	21	.	.	.
cord-295807-68sukdb1	602	1	Consequently	consequently	RB
cord-295807-68sukdb1	602	2	,	,	,
cord-295807-68sukdb1	602	3	Ae1-null	Ae1-null	NNP
cord-295807-68sukdb1	602	4	mice	mouse	NNS
cord-295807-68sukdb1	602	5	are	be	VBP
cord-295807-68sukdb1	602	6	immune	immune	JJ
cord-295807-68sukdb1	602	7	to	to	IN
cord-295807-68sukdb1	602	8	infection	infection	NN
cord-295807-68sukdb1	602	9	[	[	-LRB-
cord-295807-68sukdb1	602	10	396	396	CD
cord-295807-68sukdb1	602	11	]	]	-RRB-
cord-295807-68sukdb1	602	12	as	as	IN
cord-295807-68sukdb1	602	13	are	be	VBP
cord-295807-68sukdb1	602	14	individuals	individual	NNS
cord-295807-68sukdb1	602	15	with	with	IN
cord-295807-68sukdb1	602	16	an	an	DT
cord-295807-68sukdb1	602	17	AE1	AE1	NNP
cord-295807-68sukdb1	602	18	defect	defect	NN
cord-295807-68sukdb1	602	19	that	that	WDT
cord-295807-68sukdb1	602	20	causes	cause	VBZ
cord-295807-68sukdb1	602	21	the	the	DT
cord-295807-68sukdb1	602	22	abnormal	abnormal	JJ
cord-295807-68sukdb1	602	23	red	red	JJ
cord-295807-68sukdb1	602	24	cell	cell	NN
cord-295807-68sukdb1	602	25	morphology	morphology	NN
cord-295807-68sukdb1	602	26	(	(	-LRB-
cord-295807-68sukdb1	602	27	South	South	NNP
cord-295807-68sukdb1	602	28	East	East	NNP
cord-295807-68sukdb1	602	29	Asian	Asian	NNP
cord-295807-68sukdb1	602	30	Ovalocytosis	Ovalocytosis	NNP
cord-295807-68sukdb1	602	31	,	,	,
cord-295807-68sukdb1	602	32	SAO	SAO	NNP
cord-295807-68sukdb1	602	33	)	)	-RRB-
cord-295807-68sukdb1	602	34	[	[	-LRB-
cord-295807-68sukdb1	602	35	397	397	CD
cord-295807-68sukdb1	602	36	]	]	-RRB-
cord-295807-68sukdb1	602	37	.	.	.
cord-295807-68sukdb1	603	1	Finally	finally	RB
cord-295807-68sukdb1	603	2	,	,	,
cord-295807-68sukdb1	603	3	malarial	malarial	JJ
cord-295807-68sukdb1	603	4	infection	infection	NN
cord-295807-68sukdb1	603	5	causes	cause	VBZ
cord-295807-68sukdb1	603	6	numerous	numerous	JJ
cord-295807-68sukdb1	603	7	metabolic	metabolic	JJ
cord-295807-68sukdb1	603	8	disturbances	disturbance	NNS
cord-295807-68sukdb1	603	9	,	,	,
cord-295807-68sukdb1	603	10	such	such	JJ
cord-295807-68sukdb1	603	11	as	as	IN
cord-295807-68sukdb1	603	12	MAc	MAc	NNP
cord-295807-68sukdb1	603	13	that	that	IN
cord-295807-68sukdb1	603	14	,	,	,
cord-295807-68sukdb1	603	15	in	in	IN
cord-295807-68sukdb1	603	16	part	part	NN
cord-295807-68sukdb1	603	17	,	,	,
cord-295807-68sukdb1	603	18	follows	follow	VBZ
cord-295807-68sukdb1	603	19	the	the	DT
cord-295807-68sukdb1	603	20	tissue	tissue	NN
cord-295807-68sukdb1	603	21	hypoxia	hypoxia	NN
cord-295807-68sukdb1	603	22	and	and	CC
cord-295807-68sukdb1	603	23	hyperlactemia	hyperlactemia	NN
cord-295807-68sukdb1	603	24	caused	cause	VBN
cord-295807-68sukdb1	603	25	by	by	IN
cord-295807-68sukdb1	603	26	blocked	block	VBN
cord-295807-68sukdb1	603	27	microvasculature	microvasculature	NN
cord-295807-68sukdb1	603	28	.	.	.
cord-295807-68sukdb1	604	1	MAc	MAc	NNP
cord-295807-68sukdb1	604	2	is	be	VBZ
cord-295807-68sukdb1	604	3	a	a	DT
cord-295807-68sukdb1	604	4	strong	strong	JJ
cord-295807-68sukdb1	604	5	prognosticator	prognosticator	NN
cord-295807-68sukdb1	604	6	of	of	IN
cord-295807-68sukdb1	604	7	fatal	fatal	JJ
cord-295807-68sukdb1	604	8	outcome	outcome	NN
cord-295807-68sukdb1	604	9	in	in	IN
cord-295807-68sukdb1	604	10	infected	infected	JJ
cord-295807-68sukdb1	604	11	individuals	individual	NNS
cord-295807-68sukdb1	604	12	[	[	-LRB-
cord-295807-68sukdb1	604	13	398	398	CD
cord-295807-68sukdb1	604	14	,	,	,
cord-295807-68sukdb1	604	15	399	399	CD
cord-295807-68sukdb1	604	16	]	]	-RRB-
cord-295807-68sukdb1	604	17	.	.	.
cord-295807-68sukdb1	605	1	Influenza	Influenza	NNP
cord-295807-68sukdb1	605	2	.	.	.
cord-295807-68sukdb1	606	1	M2	M2	NNP
cord-295807-68sukdb1	606	2	H	H	NNP
cord-295807-68sukdb1	607	1	+	+	CC
cord-295807-68sukdb1	608	1	-channel	-channel	NN
cord-295807-68sukdb1	608	2	blockers	blocker	NNS
cord-295807-68sukdb1	608	3	have	have	VBP
cord-295807-68sukdb1	608	4	potential	potential	NN
cord-295807-68sukdb1	608	5	to	to	TO
cord-295807-68sukdb1	608	6	target	target	VB
cord-295807-68sukdb1	608	7	influenza	influenza	NN
cord-295807-68sukdb1	608	8	strains	strain	NNS
cord-295807-68sukdb1	608	9	that	that	WDT
cord-295807-68sukdb1	608	10	are	be	VBP
cord-295807-68sukdb1	608	11	resistant	resistant	JJ
cord-295807-68sukdb1	608	12	to	to	IN
cord-295807-68sukdb1	608	13	currently	currently	RB
cord-295807-68sukdb1	608	14	available	available	JJ
cord-295807-68sukdb1	608	15	antiviral	antiviral	JJ
cord-295807-68sukdb1	608	16	treatments	treatment	NNS
cord-295807-68sukdb1	608	17	[	[	-LRB-
cord-295807-68sukdb1	608	18	400	400	CD
cord-295807-68sukdb1	608	19	]	]	-RRB-
cord-295807-68sukdb1	608	20	.	.	.
cord-295807-68sukdb1	609	1	On	on	IN
cord-295807-68sukdb1	609	2	the	the	DT
cord-295807-68sukdb1	609	3	other	other	JJ
cord-295807-68sukdb1	609	4	hand	hand	NN
cord-295807-68sukdb1	609	5	,	,	,
cord-295807-68sukdb1	609	6	the	the	DT
cord-295807-68sukdb1	609	7	use	use	NN
cord-295807-68sukdb1	609	8	of	of	IN
cord-295807-68sukdb1	609	9	PPIs	ppi	NNS
cord-295807-68sukdb1	609	10	may	may	MD
cord-295807-68sukdb1	609	11	paradoxically	paradoxically	RB
cord-295807-68sukdb1	609	12	increase	increase	VB
cord-295807-68sukdb1	609	13	susceptibility	susceptibility	NN
cord-295807-68sukdb1	609	14	to	to	IN
cord-295807-68sukdb1	609	15	viral	viral	JJ
cord-295807-68sukdb1	609	16	infection	infection	NN
cord-295807-68sukdb1	609	17	in	in	IN
cord-295807-68sukdb1	609	18	the	the	DT
cord-295807-68sukdb1	609	19	gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	609	20	tract	tract	NN
cord-295807-68sukdb1	609	21	by	by	IN
cord-295807-68sukdb1	609	22	neutralizing	neutralize	VBG
cord-295807-68sukdb1	609	23	the	the	DT
cord-295807-68sukdb1	609	24	stomach	stomach	NN
cord-295807-68sukdb1	609	25	acidity	acidity	NN
cord-295807-68sukdb1	609	26	that	that	WDT
cord-295807-68sukdb1	609	27	typically	typically	RB
cord-295807-68sukdb1	609	28	destroys	destroy	VBZ
cord-295807-68sukdb1	609	29	viral	viral	JJ
cord-295807-68sukdb1	609	30	particles	particle	NNS
cord-295807-68sukdb1	609	31	[	[	-LRB-
cord-295807-68sukdb1	609	32	401	401	CD
cord-295807-68sukdb1	609	33	]	]	-RRB-
cord-295807-68sukdb1	609	34	.	.	.
cord-295807-68sukdb1	610	1	Lactic	lactic	JJ
cord-295807-68sukdb1	610	2	acidosis	acidosis	NN
cord-295807-68sukdb1	610	3	in	in	IN
cord-295807-68sukdb1	610	4	malaria	malaria	NN
cord-295807-68sukdb1	610	5	can	can	MD
cord-295807-68sukdb1	610	6	be	be	VB
cord-295807-68sukdb1	610	7	ameliorated	ameliorate	VBN
cord-295807-68sukdb1	610	8	by	by	IN
cord-295807-68sukdb1	610	9	dichloroacetate	dichloroacetate	NN
cord-295807-68sukdb1	610	10	treatment	treatment	NN
cord-295807-68sukdb1	610	11	[	[	-LRB-
cord-295807-68sukdb1	610	12	402	402	CD
cord-295807-68sukdb1	610	13	]	]	-RRB-
cord-295807-68sukdb1	610	14	.	.	.
cord-295807-68sukdb1	611	1	Malarial	malarial	JJ
cord-295807-68sukdb1	611	2	resistance	resistance	NN
cord-295807-68sukdb1	611	3	in	in	IN
cord-295807-68sukdb1	611	4	individuals	individual	NNS
cord-295807-68sukdb1	611	5	with	with	IN
cord-295807-68sukdb1	611	6	SAO	SAO	NNP
cord-295807-68sukdb1	611	7	suggests	suggest	VBZ
cord-295807-68sukdb1	611	8	that	that	IN
cord-295807-68sukdb1	611	9	transfusions	transfusion	NNS
cord-295807-68sukdb1	611	10	with	with	IN
cord-295807-68sukdb1	611	11	SAO	SAO	NNP
cord-295807-68sukdb1	611	12	blood	blood	NN
cord-295807-68sukdb1	611	13	may	may	MD
cord-295807-68sukdb1	611	14	be	be	VB
cord-295807-68sukdb1	611	15	a	a	DT
cord-295807-68sukdb1	611	16	useful	useful	JJ
cord-295807-68sukdb1	611	17	therapy	therapy	NN
cord-295807-68sukdb1	611	18	for	for	IN
cord-295807-68sukdb1	611	19	individuals	individual	NNS
cord-295807-68sukdb1	611	20	infected	infect	VBN
cord-295807-68sukdb1	611	21	with	with	IN
cord-295807-68sukdb1	611	22	drug	drug	NN
cord-295807-68sukdb1	611	23	-	-	HYPH
cord-295807-68sukdb1	611	24	resistant	resistant	JJ
cord-295807-68sukdb1	611	25	Plasmodium	Plasmodium	NNP
cord-295807-68sukdb1	611	26	[	[	-LRB-
cord-295807-68sukdb1	611	27	403	403	CD
cord-295807-68sukdb1	611	28	]	]	-RRB-
cord-295807-68sukdb1	611	29	.	.	.
cord-295807-68sukdb1	612	1	Finally	finally	RB
cord-295807-68sukdb1	612	2	,	,	,
cord-295807-68sukdb1	612	3	the	the	DT
cord-295807-68sukdb1	612	4	parasite	parasite	NN
cord-295807-68sukdb1	612	5	's	's	POS
cord-295807-68sukdb1	612	6	own	own	JJ
cord-295807-68sukdb1	612	7	ABTs	abt	NNS
cord-295807-68sukdb1	612	8	may	may	MD
cord-295807-68sukdb1	612	9	be	be	VB
cord-295807-68sukdb1	612	10	a	a	DT
cord-295807-68sukdb1	612	11	target	target	NN
cord-295807-68sukdb1	612	12	for	for	IN
cord-295807-68sukdb1	612	13	antimalarial	antimalarial	JJ
cord-295807-68sukdb1	612	14	action	action	NN
cord-295807-68sukdb1	612	15	[	[	-LRB-
cord-295807-68sukdb1	612	16	404	404	CD
cord-295807-68sukdb1	612	17	]	]	-RRB-
cord-295807-68sukdb1	612	18	.	.	.
cord-295807-68sukdb1	613	1	The	the	DT
cord-295807-68sukdb1	613	2	rapid	rapid	JJ
cord-295807-68sukdb1	613	3	proliferation	proliferation	NN
cord-295807-68sukdb1	613	4	of	of	IN
cord-295807-68sukdb1	613	5	cancerous	cancerous	JJ
cord-295807-68sukdb1	613	6	cells	cell	NNS
cord-295807-68sukdb1	613	7	is	be	VBZ
cord-295807-68sukdb1	613	8	associated	associate	VBN
cord-295807-68sukdb1	613	9	with	with	IN
cord-295807-68sukdb1	613	10	the	the	DT
cord-295807-68sukdb1	613	11	Warburg	Warburg	NNP
cord-295807-68sukdb1	613	12	effect	effect	NN
cord-295807-68sukdb1	613	13	(	(	-LRB-
cord-295807-68sukdb1	613	14	also	also	RB
cord-295807-68sukdb1	613	15	known	know	VBN
cord-295807-68sukdb1	613	16	as	as	IN
cord-295807-68sukdb1	613	17	'	'	``
cord-295807-68sukdb1	613	18	aerobic	aerobic	JJ
cord-295807-68sukdb1	613	19	glycolysis	glycolysis	NN
cord-295807-68sukdb1	613	20	'	'	''
cord-295807-68sukdb1	613	21	)	)	-RRB-
cord-295807-68sukdb1	613	22	:	:	:
cord-295807-68sukdb1	613	23	a	a	DT
cord-295807-68sukdb1	613	24	shift	shift	NN
cord-295807-68sukdb1	613	25	from	from	IN
cord-295807-68sukdb1	613	26	aerobic	aerobic	JJ
cord-295807-68sukdb1	613	27	to	to	IN
cord-295807-68sukdb1	613	28	anaerobic	anaerobic	JJ
cord-295807-68sukdb1	613	29	metabolism	metabolism	NN
cord-295807-68sukdb1	613	30	even	even	RB
cord-295807-68sukdb1	613	31	in	in	IN
cord-295807-68sukdb1	613	32	the	the	DT
cord-295807-68sukdb1	613	33	presence	presence	NN
cord-295807-68sukdb1	613	34	of	of	IN
cord-295807-68sukdb1	613	35	oxygen	oxygen	NN
cord-295807-68sukdb1	613	36	[	[	-LRB-
cord-295807-68sukdb1	613	37	405	405	CD
cord-295807-68sukdb1	613	38	,	,	,
cord-295807-68sukdb1	613	39	406	406	CD
cord-295807-68sukdb1	613	40	]	]	-RRB-
cord-295807-68sukdb1	613	41	.	.	.
cord-295807-68sukdb1	614	1	In	in	IN
cord-295807-68sukdb1	614	2	this	this	DT
cord-295807-68sukdb1	614	3	state	state	NN
cord-295807-68sukdb1	614	4	,	,	,
cord-295807-68sukdb1	614	5	cells	cell	NNS
cord-295807-68sukdb1	614	6	increase	increase	VBP
cord-295807-68sukdb1	614	7	their	-PRON-	PRP$
cord-295807-68sukdb1	614	8	ATP	ATP	NNP
cord-295807-68sukdb1	614	9	production	production	NN
cord-295807-68sukdb1	614	10	by	by	IN
cord-295807-68sukdb1	614	11	increasing	increase	VBG
cord-295807-68sukdb1	614	12	their	-PRON-	PRP$
cord-295807-68sukdb1	614	13	glucose	glucose	NN
cord-295807-68sukdb1	614	14	uptake	uptake	NN
cord-295807-68sukdb1	614	15	with	with	IN
cord-295807-68sukdb1	614	16	the	the	DT
cord-295807-68sukdb1	614	17	consequence	consequence	NN
cord-295807-68sukdb1	614	18	of	of	IN
cord-295807-68sukdb1	614	19	increased	increased	JJ
cord-295807-68sukdb1	614	20	lactate	lactate	NN
cord-295807-68sukdb1	614	21	and	and	CC
cord-295807-68sukdb1	614	22	H	h	NN
cord-295807-68sukdb1	614	23	+	+	CC
cord-295807-68sukdb1	614	24	production	production	NN
cord-295807-68sukdb1	614	25	.	.	.
cord-295807-68sukdb1	615	1	Because	because	IN
cord-295807-68sukdb1	615	2	of	of	IN
cord-295807-68sukdb1	615	3	their	-PRON-	PRP$
cord-295807-68sukdb1	615	4	high	high	JJ
cord-295807-68sukdb1	615	5	metabolic	metabolic	JJ
cord-295807-68sukdb1	615	6	rates	rate	NNS
cord-295807-68sukdb1	615	7	,	,	,
cord-295807-68sukdb1	615	8	such	such	JJ
cord-295807-68sukdb1	615	9	cells	cell	NNS
cord-295807-68sukdb1	615	10	would	would	MD
cord-295807-68sukdb1	615	11	tend	tend	VB
cord-295807-68sukdb1	615	12	to	to	TO
cord-295807-68sukdb1	615	13	have	have	VB
cord-295807-68sukdb1	615	14	a	a	DT
cord-295807-68sukdb1	615	15	much	much	RB
cord-295807-68sukdb1	615	16	lower	low	JJR
cord-295807-68sukdb1	615	17	pHi	pHi	NNS
cord-295807-68sukdb1	615	18	than	than	IN
cord-295807-68sukdb1	615	19	normal	normal	JJ
cord-295807-68sukdb1	615	20	cells	cell	NNS
cord-295807-68sukdb1	615	21	.	.	.
cord-295807-68sukdb1	616	1	However	however	RB
cord-295807-68sukdb1	616	2	,	,	,
cord-295807-68sukdb1	616	3	cancer	cancer	NN
cord-295807-68sukdb1	616	4	cells	cell	NNS
cord-295807-68sukdb1	616	5	are	be	VBP
cord-295807-68sukdb1	616	6	able	able	JJ
cord-295807-68sukdb1	616	7	to	to	TO
cord-295807-68sukdb1	616	8	maintain	maintain	VB
cord-295807-68sukdb1	616	9	near	near	RB
cord-295807-68sukdb1	616	10	-	-	HYPH
cord-295807-68sukdb1	616	11	normal	normal	JJ
cord-295807-68sukdb1	616	12	pHi	pHi	NNS
cord-295807-68sukdb1	616	13	by	by	IN
cord-295807-68sukdb1	616	14	upregulating	upregulate	VBG
cord-295807-68sukdb1	616	15	acid	acid	NN
cord-295807-68sukdb1	616	16	-	-	HYPH
cord-295807-68sukdb1	616	17	extruding	extrude	VBG
cord-295807-68sukdb1	616	18	ABTs	abt	NNS
cord-295807-68sukdb1	616	19	such	such	JJ
cord-295807-68sukdb1	616	20	as	as	IN
cord-295807-68sukdb1	616	21	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	616	22	,	,	,
cord-295807-68sukdb1	616	23	NBCn1	NBCn1	NNP
cord-295807-68sukdb1	616	24	,	,	,
cord-295807-68sukdb1	616	25	NHE1	NHE1	NNP
cord-295807-68sukdb1	616	26	,	,	,
cord-295807-68sukdb1	616	27	H	H	NNP
cord-295807-68sukdb1	616	28	+	+	CC
cord-295807-68sukdb1	616	29	-ATPase	-atpase	NN
cord-295807-68sukdb1	616	30	,	,	,
cord-295807-68sukdb1	616	31	and	and	CC
cord-295807-68sukdb1	616	32	MCT4	MCT4	NNP
cord-295807-68sukdb1	616	33	to	to	TO
cord-295807-68sukdb1	616	34	facilitate	facilitate	VB
cord-295807-68sukdb1	616	35	the	the	DT
cord-295807-68sukdb1	616	36	removal	removal	NN
cord-295807-68sukdb1	616	37	of	of	IN
cord-295807-68sukdb1	616	38	H	H	NNP
cord-295807-68sukdb1	616	39	+	+	CC
cord-295807-68sukdb1	616	40	,	,	,
cord-295807-68sukdb1	616	41	as	as	RB
cord-295807-68sukdb1	616	42	well	well	RB
cord-295807-68sukdb1	616	43	as	as	IN
cord-295807-68sukdb1	616	44	extracellular	extracellular	JJ
cord-295807-68sukdb1	616	45	CAs	ca	NNS
cord-295807-68sukdb1	616	46	(	(	-LRB-
cord-295807-68sukdb1	616	47	CAIX	CAIX	NNP
cord-295807-68sukdb1	616	48	,	,	,
cord-295807-68sukdb1	616	49	CAXII	CAXII	NNP
cord-295807-68sukdb1	616	50	)	)	-RRB-
cord-295807-68sukdb1	616	51	to	to	TO
cord-295807-68sukdb1	616	52	facilitate	facilitate	VB
cord-295807-68sukdb1	616	53	the	the	DT
cord-295807-68sukdb1	616	54	removal	removal	NN
cord-295807-68sukdb1	616	55	of	of	IN
cord-295807-68sukdb1	616	56	CO2	CO2	NNP
cord-295807-68sukdb1	616	57	[	[	-LRB-
cord-295807-68sukdb1	616	58	407	407	CD
cord-295807-68sukdb1	616	59	]	]	-RRB-
cord-295807-68sukdb1	616	60	[	[	-LRB-
cord-295807-68sukdb1	616	61	408	408	CD
cord-295807-68sukdb1	616	62	]	]	-RRB-
cord-295807-68sukdb1	616	63	[	[	-LRB-
cord-295807-68sukdb1	616	64	409	409	CD
cord-295807-68sukdb1	616	65	]	]	-RRB-
cord-295807-68sukdb1	616	66	[	[	-LRB-
cord-295807-68sukdb1	616	67	410	410	CD
cord-295807-68sukdb1	616	68	]	]	-RRB-
cord-295807-68sukdb1	616	69	[	[	-LRB-
cord-295807-68sukdb1	616	70	411	411	CD
cord-295807-68sukdb1	616	71	]	]	-RRB-
cord-295807-68sukdb1	616	72	.	.	.
cord-295807-68sukdb1	617	1	Aquaporins	Aquaporins	NNP
cord-295807-68sukdb1	617	2	(	(	-LRB-
cord-295807-68sukdb1	617	3	AQPs)-which	AQPs)-which	NNP
cord-295807-68sukdb1	617	4	can	can	MD
cord-295807-68sukdb1	617	5	serve	serve	VB
cord-295807-68sukdb1	617	6	as	as	IN
cord-295807-68sukdb1	617	7	a	a	DT
cord-295807-68sukdb1	617	8	conduit	conduit	NN
cord-295807-68sukdb1	617	9	for	for	IN
cord-295807-68sukdb1	617	10	transmembrane	transmembrane	JJ
cord-295807-68sukdb1	617	11	movements	movement	NNS
cord-295807-68sukdb1	617	12	of	of	IN
cord-295807-68sukdb1	617	13	CO2	CO2	NNP
cord-295807-68sukdb1	617	14	[	[	-LRB-
cord-295807-68sukdb1	617	15	412	412	CD
cord-295807-68sukdb1	617	16	]	]	-RRB-
cord-295807-68sukdb1	618	1	-also	-also	RB
cord-295807-68sukdb1	618	2	promote	promote	VB
cord-295807-68sukdb1	618	3	tumor	tumor	NN
cord-295807-68sukdb1	618	4	growth	growth	NN
cord-295807-68sukdb1	618	5	and	and	CC
cord-295807-68sukdb1	618	6	survival	survival	NN
cord-295807-68sukdb1	618	7	,	,	,
cord-295807-68sukdb1	618	8	but	but	CC
cord-295807-68sukdb1	618	9	it	-PRON-	PRP
cord-295807-68sukdb1	618	10	is	be	VBZ
cord-295807-68sukdb1	618	11	not	not	RB
cord-295807-68sukdb1	618	12	clear	clear	JJ
cord-295807-68sukdb1	618	13	that	that	IN
cord-295807-68sukdb1	618	14	promotion	promotion	NN
cord-295807-68sukdb1	618	15	of	of	IN
cord-295807-68sukdb1	618	16	CO2	CO2	NNP
cord-295807-68sukdb1	618	17	removal	removal	NN
cord-295807-68sukdb1	618	18	is	be	VBZ
cord-295807-68sukdb1	618	19	a	a	DT
cord-295807-68sukdb1	618	20	major	major	JJ
cord-295807-68sukdb1	618	21	part	part	NN
cord-295807-68sukdb1	618	22	of	of	IN
cord-295807-68sukdb1	618	23	their	-PRON-	PRP$
cord-295807-68sukdb1	618	24	pathological	pathological	JJ
cord-295807-68sukdb1	618	25	importance	importance	NN
cord-295807-68sukdb1	618	26	[	[	-LRB-
cord-295807-68sukdb1	618	27	407	407	CD
cord-295807-68sukdb1	618	28	,	,	,
cord-295807-68sukdb1	618	29	413	413	CD
cord-295807-68sukdb1	618	30	,	,	,
cord-295807-68sukdb1	618	31	414	414	CD
cord-295807-68sukdb1	618	32	]	]	-RRB-
cord-295807-68sukdb1	618	33	.	.	.
cord-295807-68sukdb1	619	1	As	as	IN
cord-295807-68sukdb1	619	2	shown	show	VBN
cord-295807-68sukdb1	619	3	in	in	IN
cord-295807-68sukdb1	619	4	cancer	cancer	NN
cord-295807-68sukdb1	619	5	cell	cell	NN
cord-295807-68sukdb1	619	6	-	-	HYPH
cord-295807-68sukdb1	619	7	lines	line	NNS
cord-295807-68sukdb1	619	8	[	[	-LRB-
cord-295807-68sukdb1	619	9	415	415	CD
cord-295807-68sukdb1	619	10	]	]	-RRB-
cord-295807-68sukdb1	619	11	,	,	,
cord-295807-68sukdb1	619	12	acidosis	acidosis	NN
cord-295807-68sukdb1	619	13	can	can	MD
cord-295807-68sukdb1	619	14	also	also	RB
cord-295807-68sukdb1	619	15	increase	increase	VB
cord-295807-68sukdb1	619	16	the	the	DT
cord-295807-68sukdb1	619	17	drive	drive	NN
cord-295807-68sukdb1	619	18	on	on	IN
cord-295807-68sukdb1	619	19	the	the	DT
cord-295807-68sukdb1	619	20	TCA	TCA	NNP
cord-295807-68sukdb1	619	21	cycle	cycle	NN
cord-295807-68sukdb1	619	22	(	(	-LRB-
cord-295807-68sukdb1	619	23	promoting	promote	VBG
cord-295807-68sukdb1	619	24	ATP	ATP	NNP
cord-295807-68sukdb1	619	25	production	production	NN
cord-295807-68sukdb1	619	26	for	for	IN
cord-295807-68sukdb1	619	27	H	h	NN
cord-295807-68sukdb1	619	28	+	+	CC
cord-295807-68sukdb1	619	29	extrusion	extrusion	NN
cord-295807-68sukdb1	619	30	)	)	-RRB-
cord-295807-68sukdb1	619	31	and	and	CC
cord-295807-68sukdb1	619	32	the	the	DT
cord-295807-68sukdb1	619	33	pentose	pentose	NN
cord-295807-68sukdb1	619	34	phosphate	phosphate	NN
cord-295807-68sukdb1	619	35	pathway	pathway	NN
cord-295807-68sukdb1	619	36	(	(	-LRB-
cord-295807-68sukdb1	619	37	promoting	promote	VBG
cord-295807-68sukdb1	619	38	NADPH	NADPH	NNP
cord-295807-68sukdb1	619	39	production	production	NN
cord-295807-68sukdb1	619	40	to	to	TO
cord-295807-68sukdb1	619	41	counter	counter	VB
cord-295807-68sukdb1	619	42	ROS	ROS	NNP
cord-295807-68sukdb1	619	43	,	,	,
cord-295807-68sukdb1	619	44	promoting	promote	VBG
cord-295807-68sukdb1	619	45	cell	cell	NN
cord-295807-68sukdb1	619	46	survival	survival	NN
cord-295807-68sukdb1	619	47	)	)	-RRB-
cord-295807-68sukdb1	619	48	[	[	-LRB-
cord-295807-68sukdb1	619	49	415	415	CD
cord-295807-68sukdb1	619	50	]	]	-RRB-
cord-295807-68sukdb1	619	51	.	.	.
cord-295807-68sukdb1	620	1	The	the	DT
cord-295807-68sukdb1	620	2	combined	combined	JJ
cord-295807-68sukdb1	620	3	action	action	NN
cord-295807-68sukdb1	620	4	of	of	IN
cord-295807-68sukdb1	620	5	these	these	DT
cord-295807-68sukdb1	620	6	processes	process	NNS
cord-295807-68sukdb1	620	7	results	result	NNS
cord-295807-68sukdb1	620	8	in	in	IN
cord-295807-68sukdb1	620	9	a	a	DT
cord-295807-68sukdb1	620	10	drastic	drastic	JJ
cord-295807-68sukdb1	620	11	reduction	reduction	NN
cord-295807-68sukdb1	620	12	in	in	IN
cord-295807-68sukdb1	620	13	local	local	JJ
cord-295807-68sukdb1	620	14	pHe	phe	NN
cord-295807-68sukdb1	620	15	.	.	.
cord-295807-68sukdb1	621	1	These	these	DT
cord-295807-68sukdb1	621	2	changes	change	NNS
cord-295807-68sukdb1	621	3	allow	allow	VBP
cord-295807-68sukdb1	621	4	cancer	cancer	NN
cord-295807-68sukdb1	621	5	cells	cell	NNS
cord-295807-68sukdb1	621	6	both	both	DT
cord-295807-68sukdb1	621	7	to	to	TO
cord-295807-68sukdb1	621	8	outcompete	outcompete	VB
cord-295807-68sukdb1	621	9	neighboring	neighboring	JJ
cord-295807-68sukdb1	621	10	non	non	JJ
cord-295807-68sukdb1	621	11	-	-	JJ
cord-295807-68sukdb1	621	12	cancer	cancer	JJ
cord-295807-68sukdb1	621	13	cells	cell	NNS
cord-295807-68sukdb1	621	14	and	and	CC
cord-295807-68sukdb1	621	15	to	to	TO
cord-295807-68sukdb1	621	16	mobilize	mobilize	VB
cord-295807-68sukdb1	621	17	and	and	CC
cord-295807-68sukdb1	621	18	spread	spread	VB
cord-295807-68sukdb1	621	19	to	to	IN
cord-295807-68sukdb1	621	20	other	other	JJ
cord-295807-68sukdb1	621	21	parts	part	NNS
cord-295807-68sukdb1	621	22	of	of	IN
cord-295807-68sukdb1	621	23	the	the	DT
cord-295807-68sukdb1	621	24	body	body	NN
cord-295807-68sukdb1	621	25	.	.	.
cord-295807-68sukdb1	622	1	Metastasis	metastasis	NN
cord-295807-68sukdb1	622	2	and	and	CC
cord-295807-68sukdb1	622	3	tumor	tumor	NN
cord-295807-68sukdb1	622	4	survival	survival	NN
cord-295807-68sukdb1	622	5	are	be	VBP
cord-295807-68sukdb1	622	6	further	further	RB
cord-295807-68sukdb1	622	7	enhanced	enhance	VBN
cord-295807-68sukdb1	622	8	by	by	IN
cord-295807-68sukdb1	622	9	acid	acid	NN
cord-295807-68sukdb1	622	10	-	-	HYPH
cord-295807-68sukdb1	622	11	dependent	dependent	JJ
cord-295807-68sukdb1	622	12	remodeling	remodeling	NN
cord-295807-68sukdb1	622	13	of	of	IN
cord-295807-68sukdb1	622	14	the	the	DT
cord-295807-68sukdb1	622	15	extracellular	extracellular	JJ
cord-295807-68sukdb1	622	16	matrix	matrix	NN
cord-295807-68sukdb1	622	17	[	[	-LRB-
cord-295807-68sukdb1	622	18	416	416	CD
cord-295807-68sukdb1	622	19	]	]	-RRB-
cord-295807-68sukdb1	622	20	and	and	CC
cord-295807-68sukdb1	622	21	suppression	suppression	NN
cord-295807-68sukdb1	622	22	of	of	IN
cord-295807-68sukdb1	622	23	anti	anti	JJ
cord-295807-68sukdb1	622	24	-	-	JJ
cord-295807-68sukdb1	622	25	tumor	tumor	JJ
cord-295807-68sukdb1	622	26	immune	immune	JJ
cord-295807-68sukdb1	622	27	responses	response	NNS
cord-295807-68sukdb1	622	28	[	[	-LRB-
cord-295807-68sukdb1	622	29	417	417	CD
cord-295807-68sukdb1	622	30	]	]	-RRB-
cord-295807-68sukdb1	622	31	(	(	-LRB-
cord-295807-68sukdb1	622	32	see	see	VB
cord-295807-68sukdb1	622	33	also	also	RB
cord-295807-68sukdb1	622	34	The	the	DT
cord-295807-68sukdb1	622	35	Immune	Immune	NNP
cord-295807-68sukdb1	622	36	System	System	NNP
cord-295807-68sukdb1	622	37	)	)	-RRB-
cord-295807-68sukdb1	622	38	.	.	.
cord-295807-68sukdb1	623	1	It	-PRON-	PRP
cord-295807-68sukdb1	623	2	is	be	VBZ
cord-295807-68sukdb1	623	3	noteworthy	noteworthy	JJ
cord-295807-68sukdb1	623	4	that	that	IN
cord-295807-68sukdb1	623	5	a	a	DT
cord-295807-68sukdb1	623	6	high	high	JJ
cord-295807-68sukdb1	623	7	level	level	NN
cord-295807-68sukdb1	623	8	of	of	IN
cord-295807-68sukdb1	623	9	net	net	JJ
cord-295807-68sukdb1	623	10	endogenous	endogenous	JJ
cord-295807-68sukdb1	623	11	acid	acid	NN
cord-295807-68sukdb1	623	12	production	production	NN
cord-295807-68sukdb1	623	13	was	be	VBD
cord-295807-68sukdb1	623	14	associated	associate	VBN
cord-295807-68sukdb1	623	15	with	with	IN
cord-295807-68sukdb1	623	16	higher	high	JJR
cord-295807-68sukdb1	623	17	mortality	mortality	NN
cord-295807-68sukdb1	623	18	in	in	IN
cord-295807-68sukdb1	623	19	breast	breast	NN
cord-295807-68sukdb1	623	20	-	-	HYPH
cord-295807-68sukdb1	623	21	cancer	cancer	NN
cord-295807-68sukdb1	623	22	recurrence	recurrence	NN
cord-295807-68sukdb1	623	23	in	in	IN
cord-295807-68sukdb1	623	24	a	a	DT
cord-295807-68sukdb1	623	25	cohort	cohort	NN
cord-295807-68sukdb1	623	26	of	of	IN
cord-295807-68sukdb1	623	27	early	early	JJ
cord-295807-68sukdb1	623	28	stage	stage	NN
cord-295807-68sukdb1	623	29	breast	breast	NN
cord-295807-68sukdb1	623	30	cancer	cancer	NN
cord-295807-68sukdb1	623	31	survivors	survivor	NNS
cord-295807-68sukdb1	623	32	[	[	-LRB-
cord-295807-68sukdb1	623	33	418	418	CD
cord-295807-68sukdb1	623	34	]	]	-RRB-
cord-295807-68sukdb1	623	35	.	.	.
cord-295807-68sukdb1	624	1	Moreover	moreover	RB
cord-295807-68sukdb1	624	2	,	,	,
cord-295807-68sukdb1	624	3	acid	acid	NN
cord-295807-68sukdb1	624	4	-	-	HYPH
cord-295807-68sukdb1	624	5	treatment	treatment	NN
cord-295807-68sukdb1	624	6	of	of	IN
cord-295807-68sukdb1	624	7	melanoma	melanoma	NN
cord-295807-68sukdb1	624	8	cells	cell	NNS
cord-295807-68sukdb1	624	9	selects	select	VBZ
cord-295807-68sukdb1	624	10	for	for	IN
cord-295807-68sukdb1	624	11	more	more	RBR
cord-295807-68sukdb1	624	12	invasive	invasive	JJ
cord-295807-68sukdb1	624	13	phenotypes	phenotype	NNS
cord-295807-68sukdb1	624	14	[	[	-LRB-
cord-295807-68sukdb1	624	15	419	419	CD
cord-295807-68sukdb1	624	16	]	]	-RRB-
cord-295807-68sukdb1	624	17	and	and	CC
cord-295807-68sukdb1	624	18	the	the	DT
cord-295807-68sukdb1	624	19	extent	extent	NN
cord-295807-68sukdb1	624	20	of	of	IN
cord-295807-68sukdb1	624	21	upregulation	upregulation	NN
cord-295807-68sukdb1	624	22	of	of	IN
cord-295807-68sukdb1	624	23	various	various	JJ
cord-295807-68sukdb1	624	24	ABTs	abt	NNS
cord-295807-68sukdb1	624	25	and	and	CC
cord-295807-68sukdb1	624	26	CAs	CAs	NNP
cord-295807-68sukdb1	624	27	can	can	MD
cord-295807-68sukdb1	624	28	be	be	VB
cord-295807-68sukdb1	624	29	an	an	DT
cord-295807-68sukdb1	624	30	adverse	adverse	JJ
cord-295807-68sukdb1	624	31	prognostic	prognostic	JJ
cord-295807-68sukdb1	624	32	factor	factor	NN
cord-295807-68sukdb1	624	33	(	(	-LRB-
cord-295807-68sukdb1	624	34	e.g.	e.g.	RB
cord-295807-68sukdb1	624	35	,	,	,
cord-295807-68sukdb1	624	36	[	[	-LRB-
cord-295807-68sukdb1	624	37	420	420	CD
cord-295807-68sukdb1	624	38	]	]	-RRB-
cord-295807-68sukdb1	624	39	[	[	-LRB-
cord-295807-68sukdb1	624	40	421	421	CD
cord-295807-68sukdb1	624	41	]	]	-RRB-
cord-295807-68sukdb1	624	42	[	[	-LRB-
cord-295807-68sukdb1	624	43	422	422	CD
cord-295807-68sukdb1	624	44	]	]	-RRB-
cord-295807-68sukdb1	624	45	)	)	-RRB-
cord-295807-68sukdb1	624	46	.	.	.
cord-295807-68sukdb1	625	1	The	the	DT
cord-295807-68sukdb1	625	2	importance	importance	NN
cord-295807-68sukdb1	625	3	of	of	IN
cord-295807-68sukdb1	625	4	acid	acid	NN
cord-295807-68sukdb1	625	5	-	-	HYPH
cord-295807-68sukdb1	625	6	base	base	NN
cord-295807-68sukdb1	625	7	balance	balance	NN
cord-295807-68sukdb1	625	8	in	in	IN
cord-295807-68sukdb1	625	9	cancer	cancer	NN
cord-295807-68sukdb1	625	10	has	have	VBZ
cord-295807-68sukdb1	625	11	suggested	suggest	VBN
cord-295807-68sukdb1	625	12	that	that	IN
cord-295807-68sukdb1	625	13	targeting	target	VBG
cord-295807-68sukdb1	625	14	tumor	tumor	NN
cord-295807-68sukdb1	625	15	pH	ph	NN
cord-295807-68sukdb1	625	16	could	could	MD
cord-295807-68sukdb1	625	17	be	be	VB
cord-295807-68sukdb1	625	18	a	a	DT
cord-295807-68sukdb1	625	19	valuable	valuable	JJ
cord-295807-68sukdb1	625	20	adjuvant	adjuvant	NN
cord-295807-68sukdb1	625	21	therapy	therapy	NN
cord-295807-68sukdb1	625	22	.	.	.
cord-295807-68sukdb1	626	1	The	the	DT
cord-295807-68sukdb1	626	2	three	three	CD
cord-295807-68sukdb1	626	3	main	main	JJ
cord-295807-68sukdb1	626	4	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	626	5	modalities	modality	NNS
cord-295807-68sukdb1	626	6	are	be	VBP
cord-295807-68sukdb1	626	7	(	(	-LRB-
cord-295807-68sukdb1	626	8	i	i	NN
cord-295807-68sukdb1	626	9	)	)	-RRB-
cord-295807-68sukdb1	626	10	interfering	interfere	VBG
cord-295807-68sukdb1	626	11	with	with	IN
cord-295807-68sukdb1	626	12	the	the	DT
cord-295807-68sukdb1	626	13	ability	ability	NN
cord-295807-68sukdb1	626	14	of	of	IN
cord-295807-68sukdb1	626	15	cancer	cancer	NN
cord-295807-68sukdb1	626	16	cells	cell	NNS
cord-295807-68sukdb1	626	17	to	to	TO
cord-295807-68sukdb1	626	18	defend	defend	VB
cord-295807-68sukdb1	626	19	their	-PRON-	PRP$
cord-295807-68sukdb1	626	20	pHi	pHi	NNS
cord-295807-68sukdb1	626	21	,	,	,
cord-295807-68sukdb1	626	22	(	(	-LRB-
cord-295807-68sukdb1	626	23	ii	ii	NN
cord-295807-68sukdb1	626	24	)	)	-RRB-
cord-295807-68sukdb1	626	25	interfering	interfere	VBG
cord-295807-68sukdb1	626	26	with	with	IN
cord-295807-68sukdb1	626	27	the	the	DT
cord-295807-68sukdb1	626	28	ability	ability	NN
cord-295807-68sukdb1	626	29	of	of	IN
cord-295807-68sukdb1	626	30	cancer	cancer	NN
cord-295807-68sukdb1	626	31	cells	cell	NNS
cord-295807-68sukdb1	626	32	to	to	TO
cord-295807-68sukdb1	626	33	create	create	VB
cord-295807-68sukdb1	626	34	an	an	DT
cord-295807-68sukdb1	626	35	acidic	acidic	JJ
cord-295807-68sukdb1	626	36	extracellular	extracellular	JJ
cord-295807-68sukdb1	626	37	environment	environment	NN
cord-295807-68sukdb1	626	38	,	,	,
cord-295807-68sukdb1	626	39	and	and	CC
cord-295807-68sukdb1	626	40	(	(	-LRB-
cord-295807-68sukdb1	626	41	iii	iii	NN
cord-295807-68sukdb1	626	42	)	)	-RRB-
cord-295807-68sukdb1	626	43	bolstering	bolster	VBG
cord-295807-68sukdb1	626	44	the	the	DT
cord-295807-68sukdb1	626	45	immune	immune	JJ
cord-295807-68sukdb1	626	46	response	response	NN
cord-295807-68sukdb1	626	47	in	in	IN
cord-295807-68sukdb1	626	48	an	an	DT
cord-295807-68sukdb1	626	49	acidic	acidic	JJ
cord-295807-68sukdb1	626	50	tumor	tumor	NN
cord-295807-68sukdb1	626	51	microenvironment	microenvironment	NN
cord-295807-68sukdb1	626	52	.	.	.
cord-295807-68sukdb1	627	1	Interfering	interfere	VBG
cord-295807-68sukdb1	627	2	with	with	IN
cord-295807-68sukdb1	627	3	pHi	phi	JJ
cord-295807-68sukdb1	627	4	defense	defense	NN
cord-295807-68sukdb1	627	5	.	.	.
cord-295807-68sukdb1	628	1	Blocking	block	VBG
cord-295807-68sukdb1	628	2	the	the	DT
cord-295807-68sukdb1	628	3	defense	defense	NN
cord-295807-68sukdb1	628	4	of	of	IN
cord-295807-68sukdb1	628	5	pHi	pHi	NNS
cord-295807-68sukdb1	628	6	by	by	IN
cord-295807-68sukdb1	628	7	cancer	cancer	NN
cord-295807-68sukdb1	628	8	cells	cell	NNS
cord-295807-68sukdb1	628	9	can	can	MD
cord-295807-68sukdb1	628	10	be	be	VB
cord-295807-68sukdb1	628	11	achieved	achieve	VBN
cord-295807-68sukdb1	628	12	by	by	IN
cord-295807-68sukdb1	628	13	inhibiting	inhibit	VBG
cord-295807-68sukdb1	628	14	acid	acid	NN
cord-295807-68sukdb1	628	15	-	-	HYPH
cord-295807-68sukdb1	628	16	extruding	extrude	VBG
cord-295807-68sukdb1	628	17	ABTs	abt	NNS
cord-295807-68sukdb1	628	18	and/or	and/or	CC
cord-295807-68sukdb1	628	19	CAs	ca	NNS
cord-295807-68sukdb1	628	20	[	[	-LRB-
cord-295807-68sukdb1	628	21	410	410	CD
cord-295807-68sukdb1	628	22	,	,	,
cord-295807-68sukdb1	628	23	423	423	CD
cord-295807-68sukdb1	628	24	]	]	-RRB-
cord-295807-68sukdb1	628	25	.	.	.
cord-295807-68sukdb1	629	1	The	the	DT
cord-295807-68sukdb1	629	2	value	value	NN
cord-295807-68sukdb1	629	3	of	of	IN
cord-295807-68sukdb1	629	4	these	these	DT
cord-295807-68sukdb1	629	5	approaches	approach	NNS
cord-295807-68sukdb1	629	6	is	be	VBZ
cord-295807-68sukdb1	629	7	demonstrated	demonstrate	VBN
cord-295807-68sukdb1	629	8	in	in	IN
cord-295807-68sukdb1	629	9	diverse	diverse	JJ
cord-295807-68sukdb1	629	10	studies	study	NNS
cord-295807-68sukdb1	629	11	that	that	WDT
cord-295807-68sukdb1	629	12	report	report	VBP
cord-295807-68sukdb1	629	13	anything	anything	NN
cord-295807-68sukdb1	629	14	from	from	IN
cord-295807-68sukdb1	629	15	delayed	delay	VBN
cord-295807-68sukdb1	629	16	tumor	tumor	NN
cord-295807-68sukdb1	629	17	-	-	HYPH
cord-295807-68sukdb1	629	18	growth	growth	NN
cord-295807-68sukdb1	629	19	in	in	IN
cord-295807-68sukdb1	629	20	NBCn1-null	nbcn1-null	CD
cord-295807-68sukdb1	629	21	mice	mouse	NNS
cord-295807-68sukdb1	629	22	[	[	-LRB-
cord-295807-68sukdb1	629	23	424	424	CD
cord-295807-68sukdb1	629	24	]	]	-RRB-
cord-295807-68sukdb1	629	25	to	to	TO
cord-295807-68sukdb1	629	26	positive	positive	JJ
cord-295807-68sukdb1	629	27	clinical	clinical	JJ
cord-295807-68sukdb1	629	28	outcomes	outcome	NNS
cord-295807-68sukdb1	629	29	with	with	IN
cord-295807-68sukdb1	629	30	adjuvant	adjuvant	JJ
cord-295807-68sukdb1	629	31	use	use	NN
cord-295807-68sukdb1	629	32	of	of	IN
cord-295807-68sukdb1	629	33	proton	proton	NN
cord-295807-68sukdb1	629	34	pump	pump	NN
cord-295807-68sukdb1	629	35	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	629	36	[	[	-LRB-
cord-295807-68sukdb1	629	37	425	425	CD
cord-295807-68sukdb1	629	38	]	]	-RRB-
cord-295807-68sukdb1	629	39	.	.	.
cord-295807-68sukdb1	630	1	However	however	RB
cord-295807-68sukdb1	630	2	,	,	,
cord-295807-68sukdb1	630	3	reports	report	NNS
cord-295807-68sukdb1	630	4	from	from	IN
cord-295807-68sukdb1	630	5	clinical	clinical	JJ
cord-295807-68sukdb1	630	6	trials	trial	NNS
cord-295807-68sukdb1	630	7	are	be	VBP
cord-295807-68sukdb1	630	8	currently	currently	RB
cord-295807-68sukdb1	630	9	sparse	sparse	JJ
cord-295807-68sukdb1	630	10	.	.	.
cord-295807-68sukdb1	631	1	Given	give	VBN
cord-295807-68sukdb1	631	2	the	the	DT
cord-295807-68sukdb1	631	3	potential	potential	NN
cord-295807-68sukdb1	631	4	for	for	IN
cord-295807-68sukdb1	631	5	side	side	NN
cord-295807-68sukdb1	631	6	effects	effect	NNS
cord-295807-68sukdb1	631	7	due	due	IN
cord-295807-68sukdb1	631	8	to	to	IN
cord-295807-68sukdb1	631	9	the	the	DT
cord-295807-68sukdb1	631	10	physiological	physiological	JJ
cord-295807-68sukdb1	631	11	importance	importance	NN
cord-295807-68sukdb1	631	12	of	of	IN
cord-295807-68sukdb1	631	13	these	these	DT
cord-295807-68sukdb1	631	14	proteins	protein	NNS
cord-295807-68sukdb1	631	15	in	in	IN
cord-295807-68sukdb1	631	16	all	all	DT
cord-295807-68sukdb1	631	17	organ	organ	NN
cord-295807-68sukdb1	631	18	systems	system	NNS
cord-295807-68sukdb1	631	19	,	,	,
cord-295807-68sukdb1	631	20	much	much	JJ
cord-295807-68sukdb1	631	21	attention	attention	NN
cord-295807-68sukdb1	631	22	has	have	VBZ
cord-295807-68sukdb1	631	23	focused	focus	VBN
cord-295807-68sukdb1	631	24	on	on	IN
cord-295807-68sukdb1	631	25	inhibiting	inhibit	VBG
cord-295807-68sukdb1	631	26	those	those	DT
cord-295807-68sukdb1	631	27	proteins	protein	NNS
cord-295807-68sukdb1	631	28	,	,	,
cord-295807-68sukdb1	631	29	such	such	JJ
cord-295807-68sukdb1	631	30	as	as	IN
cord-295807-68sukdb1	631	31	CAIX	CAIX	NNP
cord-295807-68sukdb1	631	32	,	,	,
cord-295807-68sukdb1	631	33	which	which	WDT
cord-295807-68sukdb1	631	34	are	be	VBP
cord-295807-68sukdb1	631	35	specifically	specifically	RB
cord-295807-68sukdb1	631	36	upregulated	upregulate	VBN
cord-295807-68sukdb1	631	37	in	in	IN
cord-295807-68sukdb1	631	38	cancer	cancer	NN
cord-295807-68sukdb1	631	39	cells	cell	NNS
cord-295807-68sukdb1	631	40	(	(	-LRB-
cord-295807-68sukdb1	631	41	in	in	IN
cord-295807-68sukdb1	631	42	response	response	NN
cord-295807-68sukdb1	631	43	to	to	IN
cord-295807-68sukdb1	631	44	hypoxia	hypoxia	NN
cord-295807-68sukdb1	631	45	)	)	-RRB-
cord-295807-68sukdb1	631	46	and	and	CC
cord-295807-68sukdb1	631	47	not	not	RB
cord-295807-68sukdb1	631	48	highly	highly	RB
cord-295807-68sukdb1	631	49	expressed	express	VBN
cord-295807-68sukdb1	631	50	elsewhere	elsewhere	RB
cord-295807-68sukdb1	631	51	[	[	-LRB-
cord-295807-68sukdb1	631	52	426	426	CD
cord-295807-68sukdb1	631	53	]	]	-RRB-
cord-295807-68sukdb1	631	54	.	.	.
cord-295807-68sukdb1	632	1	Another	another	DT
cord-295807-68sukdb1	632	2	approach	approach	NN
cord-295807-68sukdb1	632	3	,	,	,
cord-295807-68sukdb1	632	4	the	the	DT
cord-295807-68sukdb1	632	5	combinatorial	combinatorial	JJ
cord-295807-68sukdb1	632	6	use	use	NN
cord-295807-68sukdb1	632	7	of	of	IN
cord-295807-68sukdb1	632	8	blockers	blocker	NNS
cord-295807-68sukdb1	632	9	,	,	,
cord-295807-68sukdb1	632	10	allows	allow	VBZ
cord-295807-68sukdb1	632	11	for	for	IN
cord-295807-68sukdb1	632	12	a	a	DT
cord-295807-68sukdb1	632	13	lower	low	JJR
cord-295807-68sukdb1	632	14	dose	dose	NN
cord-295807-68sukdb1	632	15	of	of	IN
cord-295807-68sukdb1	632	16	each	each	DT
cord-295807-68sukdb1	632	17	and	and	CC
cord-295807-68sukdb1	632	18	thus	thus	RB
cord-295807-68sukdb1	632	19	fewer	few	JJR
cord-295807-68sukdb1	632	20	undesired	undesired	JJ
cord-295807-68sukdb1	632	21	effects	effect	NNS
cord-295807-68sukdb1	632	22	on	on	IN
cord-295807-68sukdb1	632	23	non	non	JJ
cord-295807-68sukdb1	632	24	-	-	JJ
cord-295807-68sukdb1	632	25	tumor	tumor	JJ
cord-295807-68sukdb1	632	26	cells	cell	NNS
cord-295807-68sukdb1	632	27	.	.	.
cord-295807-68sukdb1	633	1	The	the	DT
cord-295807-68sukdb1	633	2	use	use	NN
cord-295807-68sukdb1	633	3	of	of	IN
cord-295807-68sukdb1	633	4	a	a	DT
cord-295807-68sukdb1	633	5	combination	combination	NN
cord-295807-68sukdb1	633	6	of	of	IN
cord-295807-68sukdb1	633	7	five	five	CD
cord-295807-68sukdb1	633	8	compounds	compound	NNS
cord-295807-68sukdb1	633	9	,	,	,
cord-295807-68sukdb1	633	10	each	each	DT
cord-295807-68sukdb1	633	11	of	of	IN
cord-295807-68sukdb1	633	12	which	which	WDT
cord-295807-68sukdb1	633	13	targets	target	VBZ
cord-295807-68sukdb1	633	14	a	a	DT
cord-295807-68sukdb1	633	15	different	different	JJ
cord-295807-68sukdb1	633	16	ABT	ABT	NNP
cord-295807-68sukdb1	633	17	/	/	SYM
cord-295807-68sukdb1	633	18	CA	CA	NNP
cord-295807-68sukdb1	633	19	,	,	,
cord-295807-68sukdb1	633	20	revealed	reveal	VBD
cord-295807-68sukdb1	633	21	effectiveness	effectiveness	NN
cord-295807-68sukdb1	633	22	at	at	IN
cord-295807-68sukdb1	633	23	reducing	reduce	VBG
cord-295807-68sukdb1	633	24	intracellular	intracellular	JJ
cord-295807-68sukdb1	633	25	brain	brain	NN
cord-295807-68sukdb1	633	26	tumor	tumor	NN
cord-295807-68sukdb1	633	27	acidification	acidification	NN
cord-295807-68sukdb1	633	28	in	in	IN
cord-295807-68sukdb1	633	29	mice	mouse	NNS
cord-295807-68sukdb1	633	30	and	and	CC
cord-295807-68sukdb1	633	31	the	the	DT
cord-295807-68sukdb1	633	32	consequent	consequent	JJ
cord-295807-68sukdb1	633	33	activation	activation	NN
cord-295807-68sukdb1	633	34	of	of	IN
cord-295807-68sukdb1	633	35	the	the	DT
cord-295807-68sukdb1	633	36	pro	pro	JJ
cord-295807-68sukdb1	633	37	-	-	JJ
cord-295807-68sukdb1	633	38	apoptotic	apoptotic	JJ
cord-295807-68sukdb1	633	39	marker	marker	NN
cord-295807-68sukdb1	633	40	caspase-3	caspase-3	NNP
cord-295807-68sukdb1	633	41	in	in	IN
cord-295807-68sukdb1	633	42	tumor	tumor	NN
cord-295807-68sukdb1	633	43	cells	cell	NNS
cord-295807-68sukdb1	633	44	,	,	,
cord-295807-68sukdb1	633	45	with	with	IN
cord-295807-68sukdb1	633	46	little	little	JJ
cord-295807-68sukdb1	633	47	negative	negative	JJ
cord-295807-68sukdb1	633	48	effect	effect	NN
cord-295807-68sukdb1	633	49	on	on	IN
cord-295807-68sukdb1	633	50	non	non	JJ
cord-295807-68sukdb1	633	51	-	-	JJ
cord-295807-68sukdb1	633	52	tumor	tumor	JJ
cord-295807-68sukdb1	633	53	cells	cell	NNS
cord-295807-68sukdb1	633	54	[	[	-LRB-
cord-295807-68sukdb1	633	55	427	427	CD
cord-295807-68sukdb1	633	56	]	]	-RRB-
cord-295807-68sukdb1	633	57	.	.	.
cord-295807-68sukdb1	634	1	Interestingly	interestingly	RB
cord-295807-68sukdb1	634	2	,	,	,
cord-295807-68sukdb1	634	3	the	the	DT
cord-295807-68sukdb1	634	4	potency	potency	NN
cord-295807-68sukdb1	634	5	of	of	IN
cord-295807-68sukdb1	634	6	such	such	JJ
cord-295807-68sukdb1	634	7	approaches	approach	NNS
cord-295807-68sukdb1	634	8	is	be	VBZ
cord-295807-68sukdb1	634	9	enhanced	enhance	VBN
cord-295807-68sukdb1	634	10	by	by	IN
cord-295807-68sukdb1	634	11	glucose	glucose	NN
cord-295807-68sukdb1	634	12	loading	loading	NN
cord-295807-68sukdb1	634	13	,	,	,
cord-295807-68sukdb1	634	14	which	which	WDT
cord-295807-68sukdb1	634	15	increases	increase	VBZ
cord-295807-68sukdb1	634	16	the	the	DT
cord-295807-68sukdb1	634	17	acid	acid	NN
cord-295807-68sukdb1	634	18	-	-	HYPH
cord-295807-68sukdb1	634	19	load	load	NN
cord-295807-68sukdb1	634	20	in	in	IN
cord-295807-68sukdb1	634	21	these	these	DT
cord-295807-68sukdb1	634	22	glycolytic	glycolytic	JJ
cord-295807-68sukdb1	634	23	tumor	tumor	NN
cord-295807-68sukdb1	634	24	cells	cell	NNS
cord-295807-68sukdb1	634	25	[	[	-LRB-
cord-295807-68sukdb1	634	26	428	428	CD
cord-295807-68sukdb1	634	27	]	]	-RRB-
cord-295807-68sukdb1	634	28	.	.	.
cord-295807-68sukdb1	635	1	Finally	finally	RB
cord-295807-68sukdb1	635	2	,	,	,
cord-295807-68sukdb1	635	3	as	as	IN
cord-295807-68sukdb1	635	4	different	different	JJ
cord-295807-68sukdb1	635	5	ABTs	abt	NNS
cord-295807-68sukdb1	635	6	/	/	SYM
cord-295807-68sukdb1	635	7	CAs	ca	NNS
cord-295807-68sukdb1	635	8	are	be	VBP
cord-295807-68sukdb1	635	9	upregulated	upregulate	VBN
cord-295807-68sukdb1	635	10	in	in	IN
cord-295807-68sukdb1	635	11	different	different	JJ
cord-295807-68sukdb1	635	12	tumor	tumor	NN
cord-295807-68sukdb1	635	13	types	type	NNS
cord-295807-68sukdb1	635	14	,	,	,
cord-295807-68sukdb1	635	15	generic	generic	JJ
cord-295807-68sukdb1	635	16	approaches	approach	NNS
cord-295807-68sukdb1	635	17	are	be	VBP
cord-295807-68sukdb1	635	18	also	also	RB
cord-295807-68sukdb1	635	19	valuable	valuable	JJ
cord-295807-68sukdb1	635	20	to	to	TO
cord-295807-68sukdb1	635	21	consider	consider	VB
cord-295807-68sukdb1	635	22	.	.	.
cord-295807-68sukdb1	636	1	For	for	IN
cord-295807-68sukdb1	636	2	example	example	NN
cord-295807-68sukdb1	636	3	,	,	,
cord-295807-68sukdb1	636	4	a	a	DT
cord-295807-68sukdb1	636	5	number	number	NN
cord-295807-68sukdb1	636	6	of	of	IN
cord-295807-68sukdb1	636	7	anticancer	anticancer	JJ
cord-295807-68sukdb1	636	8	drugs	drug	NNS
cord-295807-68sukdb1	636	9	,	,	,
cord-295807-68sukdb1	636	10	such	such	JJ
cord-295807-68sukdb1	636	11	as	as	IN
cord-295807-68sukdb1	636	12	salinomycin	salinomycin	NNS
cord-295807-68sukdb1	636	13	,	,	,
cord-295807-68sukdb1	636	14	that	that	WDT
cord-295807-68sukdb1	636	15	are	be	VBP
cord-295807-68sukdb1	636	16	not	not	RB
cord-295807-68sukdb1	636	17	known	know	VBN
cord-295807-68sukdb1	636	18	to	to	TO
cord-295807-68sukdb1	636	19	specifically	specifically	RB
cord-295807-68sukdb1	636	20	target	target	VB
cord-295807-68sukdb1	636	21	ABTs	ABTs	NNP
cord-295807-68sukdb1	636	22	or	or	CC
cord-295807-68sukdb1	636	23	CAs	CAs	NNP
cord-295807-68sukdb1	636	24	,	,	,
cord-295807-68sukdb1	636	25	also	also	RB
cord-295807-68sukdb1	636	26	promote	promote	VB
cord-295807-68sukdb1	636	27	cellular	cellular	JJ
cord-295807-68sukdb1	636	28	acidification	acidification	NN
cord-295807-68sukdb1	636	29	[	[	-LRB-
cord-295807-68sukdb1	636	30	423	423	CD
cord-295807-68sukdb1	636	31	]	]	-RRB-
cord-295807-68sukdb1	636	32	.	.	.
cord-295807-68sukdb1	637	1	Interfering	interfere	VBG
cord-295807-68sukdb1	637	2	with	with	IN
cord-295807-68sukdb1	637	3	extracellular	extracellular	JJ
cord-295807-68sukdb1	637	4	acidification	acidification	NN
cord-295807-68sukdb1	637	5	.	.	.
cord-295807-68sukdb1	638	1	Anecdotal	anecdotal	JJ
cord-295807-68sukdb1	638	2	evidence	evidence	NN
cord-295807-68sukdb1	638	3	suggests	suggest	VBZ
cord-295807-68sukdb1	638	4	that	that	IN
cord-295807-68sukdb1	638	5	interfering	interfere	VBG
cord-295807-68sukdb1	638	6	with	with	IN
cord-295807-68sukdb1	638	7	extracellular	extracellular	JJ
cord-295807-68sukdb1	638	8	acidification	acidification	NN
cord-295807-68sukdb1	638	9	might	may	MD
cord-295807-68sukdb1	638	10	be	be	VB
cord-295807-68sukdb1	638	11	achieved	achieve	VBN
cord-295807-68sukdb1	638	12	by	by	IN
cord-295807-68sukdb1	638	13	dietary	dietary	JJ
cord-295807-68sukdb1	638	14	means	mean	NNS
cord-295807-68sukdb1	638	15	[	[	-LRB-
cord-295807-68sukdb1	638	16	429	429	CD
cord-295807-68sukdb1	638	17	]	]	-RRB-
cord-295807-68sukdb1	638	18	.	.	.
cord-295807-68sukdb1	639	1	Indeed	indeed	RB
cord-295807-68sukdb1	639	2	,	,	,
cord-295807-68sukdb1	639	3	oral	oral	JJ
cord-295807-68sukdb1	639	4	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	639	5	supplementation	supplementation	NN
cord-295807-68sukdb1	639	6	can	can	MD
cord-295807-68sukdb1	639	7	raise	raise	VB
cord-295807-68sukdb1	639	8	tumor	tumor	NN
cord-295807-68sukdb1	639	9	pHe	phe	NN
cord-295807-68sukdb1	639	10	and	and	CC
cord-295807-68sukdb1	639	11	inhibit	inhibit	VBP
cord-295807-68sukdb1	639	12	metastasis	metastasis	NN
cord-295807-68sukdb1	639	13	in	in	IN
cord-295807-68sukdb1	639	14	mice	mouse	NNS
cord-295807-68sukdb1	639	15	[	[	-LRB-
cord-295807-68sukdb1	639	16	430	430	CD
cord-295807-68sukdb1	639	17	]	]	-RRB-
cord-295807-68sukdb1	639	18	,	,	,
cord-295807-68sukdb1	639	19	but	but	CC
cord-295807-68sukdb1	639	20	the	the	DT
cord-295807-68sukdb1	639	21	overall	overall	JJ
cord-295807-68sukdb1	639	22	consequence	consequence	NN
cord-295807-68sukdb1	639	23	is	be	VBZ
cord-295807-68sukdb1	639	24	complex	complex	JJ
cord-295807-68sukdb1	639	25	,	,	,
cord-295807-68sukdb1	639	26	with	with	IN
cord-295807-68sukdb1	639	27	one	one	CD
cord-295807-68sukdb1	639	28	recent	recent	JJ
cord-295807-68sukdb1	639	29	study	study	NN
cord-295807-68sukdb1	639	30	suggesting	suggest	VBG
cord-295807-68sukdb1	639	31	that	that	IN
cord-295807-68sukdb1	639	32	such	such	JJ
cord-295807-68sukdb1	639	33	therapy	therapy	NN
cord-295807-68sukdb1	639	34	may	may	MD
cord-295807-68sukdb1	639	35	confoundingly	confoundingly	RB
cord-295807-68sukdb1	639	36	promote	promote	VB
cord-295807-68sukdb1	639	37	tumor	tumor	NN
cord-295807-68sukdb1	639	38	proliferation	proliferation	NN
cord-295807-68sukdb1	639	39	[	[	-LRB-
cord-295807-68sukdb1	639	40	431	431	CD
cord-295807-68sukdb1	639	41	]	]	-RRB-
cord-295807-68sukdb1	639	42	.	.	.
cord-295807-68sukdb1	640	1	However	however	RB
cord-295807-68sukdb1	640	2	,	,	,
cord-295807-68sukdb1	640	3	the	the	DT
cord-295807-68sukdb1	640	4	addition	addition	NN
cord-295807-68sukdb1	640	5	of	of	IN
cord-295807-68sukdb1	640	6	adjuvant	adjuvant	JJ
cord-295807-68sukdb1	640	7	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	640	8	to	to	IN
cord-295807-68sukdb1	640	9	a	a	DT
cord-295807-68sukdb1	640	10	chemotherapeutic	chemotherapeutic	JJ
cord-295807-68sukdb1	640	11	agent	agent	NN
cord-295807-68sukdb1	640	12	that	that	WDT
cord-295807-68sukdb1	640	13	was	be	VBD
cord-295807-68sukdb1	640	14	fed	feed	VBN
cord-295807-68sukdb1	640	15	directly	directly	RB
cord-295807-68sukdb1	640	16	into	into	IN
cord-295807-68sukdb1	640	17	a	a	DT
cord-295807-68sukdb1	640	18	hepatic	hepatic	JJ
cord-295807-68sukdb1	640	19	tumor	tumor	NN
cord-295807-68sukdb1	640	20	via	via	IN
cord-295807-68sukdb1	640	21	catherization	catherization	NN
cord-295807-68sukdb1	640	22	of	of	IN
cord-295807-68sukdb1	640	23	tumorfeeding	tumorfeede	VBG
cord-295807-68sukdb1	640	24	arteries	artery	NNS
cord-295807-68sukdb1	640	25	(	(	-LRB-
cord-295807-68sukdb1	640	26	TILA	TILA	NNP
cord-295807-68sukdb1	640	27	-	-	HYPH
cord-295807-68sukdb1	640	28	TACE	TACE	NNP
cord-295807-68sukdb1	640	29	:	:	:
cord-295807-68sukdb1	640	30	targeting	target	VBG
cord-295807-68sukdb1	640	31	intra	intra	JJ
cord-295807-68sukdb1	640	32	-	-	JJ
cord-295807-68sukdb1	640	33	tumoral	tumoral	JJ
cord-295807-68sukdb1	640	34	lactic	lactic	JJ
cord-295807-68sukdb1	640	35	acidosis	acidosis	NN
cord-295807-68sukdb1	640	36	with	with	IN
cord-295807-68sukdb1	640	37	trans	trans	JJ
cord-295807-68sukdb1	640	38	-	-	JJ
cord-295807-68sukdb1	640	39	arterial	arterial	JJ
cord-295807-68sukdb1	640	40	chemoembolization	chemoembolization	NN
cord-295807-68sukdb1	640	41	)	)	-RRB-
cord-295807-68sukdb1	640	42	was	be	VBD
cord-295807-68sukdb1	640	43	associated	associate	VBN
cord-295807-68sukdb1	640	44	with	with	IN
cord-295807-68sukdb1	640	45	markedly	markedly	RB
cord-295807-68sukdb1	640	46	improved	improve	VBN
cord-295807-68sukdb1	640	47	outcomes	outcome	NNS
cord-295807-68sukdb1	640	48	[	[	-LRB-
cord-295807-68sukdb1	640	49	432	432	CD
cord-295807-68sukdb1	640	50	]	]	-RRB-
cord-295807-68sukdb1	640	51	.	.	.
cord-295807-68sukdb1	641	1	In	in	IN
cord-295807-68sukdb1	641	2	short	short	JJ
cord-295807-68sukdb1	641	3	,	,	,
cord-295807-68sukdb1	641	4	there	there	EX
cord-295807-68sukdb1	641	5	is	be	VBZ
cord-295807-68sukdb1	641	6	currently	currently	RB
cord-295807-68sukdb1	641	7	insufficient	insufficient	JJ
cord-295807-68sukdb1	641	8	data	datum	NNS
cord-295807-68sukdb1	641	9	to	to	TO
cord-295807-68sukdb1	641	10	show	show	VB
cord-295807-68sukdb1	641	11	that	that	IN
cord-295807-68sukdb1	641	12	lowering	lower	VBG
cord-295807-68sukdb1	641	13	dietary	dietary	JJ
cord-295807-68sukdb1	641	14	acid	acid	NN
cord-295807-68sukdb1	641	15	load	load	NN
cord-295807-68sukdb1	641	16	improves	improve	VBZ
cord-295807-68sukdb1	641	17	outcomes	outcome	NNS
cord-295807-68sukdb1	641	18	,	,	,
cord-295807-68sukdb1	641	19	except	except	IN
cord-295807-68sukdb1	641	20	by	by	IN
cord-295807-68sukdb1	641	21	virtue	virtue	NN
cord-295807-68sukdb1	641	22	of	of	IN
cord-295807-68sukdb1	641	23	the	the	DT
cord-295807-68sukdb1	641	24	association	association	NN
cord-295807-68sukdb1	641	25	of	of	IN
cord-295807-68sukdb1	641	26	such	such	JJ
cord-295807-68sukdb1	641	27	diets	diet	NNS
cord-295807-68sukdb1	641	28	with	with	IN
cord-295807-68sukdb1	641	29	general	general	JJ
cord-295807-68sukdb1	641	30	well	well	RB
cord-295807-68sukdb1	641	31	-	-	HYPH
cord-295807-68sukdb1	641	32	being	be	VBG
cord-295807-68sukdb1	641	33	[	[	-LRB-
cord-295807-68sukdb1	641	34	433	433	CD
cord-295807-68sukdb1	641	35	]	]	-RRB-
cord-295807-68sukdb1	642	1	and	and	CC
cord-295807-68sukdb1	642	2	the	the	DT
cord-295807-68sukdb1	642	3	role	role	NN
cord-295807-68sukdb1	642	4	of	of	IN
cord-295807-68sukdb1	642	5	alkalinization	alkalinization	NN
cord-295807-68sukdb1	642	6	in	in	IN
cord-295807-68sukdb1	642	7	enhancing	enhance	VBG
cord-295807-68sukdb1	642	8	the	the	DT
cord-295807-68sukdb1	642	9	safety	safety	NN
cord-295807-68sukdb1	642	10	of	of	IN
cord-295807-68sukdb1	642	11	certain	certain	JJ
cord-295807-68sukdb1	642	12	chemotherapeutic	chemotherapeutic	JJ
cord-295807-68sukdb1	642	13	drugs	drug	NNS
cord-295807-68sukdb1	642	14	(	(	-LRB-
cord-295807-68sukdb1	642	15	[	[	-LRB-
cord-295807-68sukdb1	642	16	434	434	CD
cord-295807-68sukdb1	642	17	]	]	-RRB-
cord-295807-68sukdb1	642	18	)	)	-RRB-
cord-295807-68sukdb1	642	19	.	.	.
cord-295807-68sukdb1	643	1	The	the	DT
cord-295807-68sukdb1	643	2	acidic	acidic	JJ
cord-295807-68sukdb1	643	3	tumor	tumor	NN
cord-295807-68sukdb1	643	4	microenvironment	microenvironment	NN
cord-295807-68sukdb1	643	5	can	can	MD
cord-295807-68sukdb1	643	6	also	also	RB
cord-295807-68sukdb1	643	7	be	be	VB
cord-295807-68sukdb1	643	8	exploited	exploit	VBN
cord-295807-68sukdb1	643	9	to	to	TO
cord-295807-68sukdb1	643	10	promote	promote	VB
cord-295807-68sukdb1	643	11	local	local	JJ
cord-295807-68sukdb1	643	12	drug	drug	NN
cord-295807-68sukdb1	643	13	delivery	delivery	NN
cord-295807-68sukdb1	643	14	as	as	IN
cord-295807-68sukdb1	643	15	discussed	discuss	VBN
cord-295807-68sukdb1	643	16	in	in	IN
cord-295807-68sukdb1	643	17	section	section	NN
cord-295807-68sukdb1	643	18	6.6	6.6	CD
cord-295807-68sukdb1	643	19	.	.	.
cord-295807-68sukdb1	644	1	Bolstering	bolster	VBG
cord-295807-68sukdb1	644	2	antitumor	antitumor	JJ
cord-295807-68sukdb1	644	3	immune	immune	JJ
cord-295807-68sukdb1	644	4	response	response	NN
cord-295807-68sukdb1	644	5	.	.	.
cord-295807-68sukdb1	645	1	The	the	DT
cord-295807-68sukdb1	645	2	acidic	acidic	JJ
cord-295807-68sukdb1	645	3	tumor	tumor	NN
cord-295807-68sukdb1	645	4	microenvironment	microenvironment	NN
cord-295807-68sukdb1	645	5	promotes	promote	VBZ
cord-295807-68sukdb1	645	6	an	an	DT
cord-295807-68sukdb1	645	7	antiinflammatory	antiinflammatory	JJ
cord-295807-68sukdb1	645	8	T	t	NN
cord-295807-68sukdb1	645	9	-	-	HYPH
cord-295807-68sukdb1	645	10	cell	cell	NN
cord-295807-68sukdb1	645	11	response	response	NN
cord-295807-68sukdb1	645	12	(	(	-LRB-
cord-295807-68sukdb1	645	13	see	see	VB
cord-295807-68sukdb1	645	14	section	section	NN
cord-295807-68sukdb1	645	15	5.6.1	5.6.1	CD
cord-295807-68sukdb1	645	16	)	)	-RRB-
cord-295807-68sukdb1	645	17	,	,	,
cord-295807-68sukdb1	645	18	but	but	CC
cord-295807-68sukdb1	645	19	the	the	DT
cord-295807-68sukdb1	645	20	deletion	deletion	NN
cord-295807-68sukdb1	645	21	of	of	IN
cord-295807-68sukdb1	645	22	AE2	AE2	NNP
cord-295807-68sukdb1	645	23	promotes	promote	VBZ
cord-295807-68sukdb1	645	24	a	a	DT
cord-295807-68sukdb1	645	25	proinflammatory	proinflammatory	JJ
cord-295807-68sukdb1	645	26	T	t	NN
cord-295807-68sukdb1	645	27	-	-	HYPH
cord-295807-68sukdb1	645	28	cell	cell	NN
cord-295807-68sukdb1	645	29	response	response	NN
cord-295807-68sukdb1	645	30	(	(	-LRB-
cord-295807-68sukdb1	645	31	see	see	VB
cord-295807-68sukdb1	645	32	section	section	NN
cord-295807-68sukdb1	645	33	4.12.1	4.12.1	CD
cord-295807-68sukdb1	645	34	)	)	-RRB-
cord-295807-68sukdb1	645	35	.	.	.
cord-295807-68sukdb1	646	1	Therefore	therefore	RB
cord-295807-68sukdb1	646	2	inhibition	inhibition	NN
cord-295807-68sukdb1	646	3	of	of	IN
cord-295807-68sukdb1	646	4	T	t	NN
cord-295807-68sukdb1	646	5	-	-	HYPH
cord-295807-68sukdb1	646	6	cell	cell	NN
cord-295807-68sukdb1	646	7	AE2	AE2	NNS
cord-295807-68sukdb1	646	8	could	could	MD
cord-295807-68sukdb1	646	9	be	be	VB
cord-295807-68sukdb1	646	10	a	a	DT
cord-295807-68sukdb1	646	11	valuable	valuable	JJ
cord-295807-68sukdb1	646	12	paradigm	paradigm	NN
cord-295807-68sukdb1	646	13	for	for	IN
cord-295807-68sukdb1	646	14	enhancing	enhance	VBG
cord-295807-68sukdb1	646	15	a	a	DT
cord-295807-68sukdb1	646	16	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	646	17	immune	immune	JJ
cord-295807-68sukdb1	646	18	response	response	NN
cord-295807-68sukdb1	646	19	[	[	-LRB-
cord-295807-68sukdb1	646	20	435	435	CD
cord-295807-68sukdb1	646	21	]	]	-RRB-
cord-295807-68sukdb1	646	22	.	.	.
cord-295807-68sukdb1	647	1	6	6	CD
cord-295807-68sukdb1	647	2	pH	ph	JJ
cord-295807-68sukdb1	647	3	-	-	HYPH
cord-295807-68sukdb1	647	4	dependent	dependent	JJ
cord-295807-68sukdb1	647	5	aspects	aspect	NNS
cord-295807-68sukdb1	647	6	of	of	IN
cord-295807-68sukdb1	647	7	pharmaceutical	pharmaceutical	JJ
cord-295807-68sukdb1	647	8	therapy	therapy	NN
cord-295807-68sukdb1	647	9	In	in	IN
cord-295807-68sukdb1	647	10	this	this	DT
cord-295807-68sukdb1	647	11	section	section	NN
cord-295807-68sukdb1	647	12	,	,	,
cord-295807-68sukdb1	647	13	we	-PRON-	PRP
cord-295807-68sukdb1	647	14	will	will	MD
cord-295807-68sukdb1	647	15	focus	focus	VB
cord-295807-68sukdb1	647	16	on	on	IN
cord-295807-68sukdb1	647	17	the	the	DT
cord-295807-68sukdb1	647	18	influence	influence	NN
cord-295807-68sukdb1	647	19	of	of	IN
cord-295807-68sukdb1	647	20	pH	ph	NN
cord-295807-68sukdb1	647	21	upon	upon	IN
cord-295807-68sukdb1	647	22	pharmacokinetic	pharmacokinetic	JJ
cord-295807-68sukdb1	647	23	properties	property	NNS
cord-295807-68sukdb1	647	24	of	of	IN
cord-295807-68sukdb1	647	25	drugs	drug	NNS
cord-295807-68sukdb1	647	26	.	.	.
cord-295807-68sukdb1	648	1	We	-PRON-	PRP
cord-295807-68sukdb1	648	2	will	will	MD
cord-295807-68sukdb1	648	3	also	also	RB
cord-295807-68sukdb1	648	4	consider	consider	VB
cord-295807-68sukdb1	648	5	how	how	WRB
cord-295807-68sukdb1	648	6	all	all	DT
cord-295807-68sukdb1	648	7	of	of	IN
cord-295807-68sukdb1	648	8	these	these	DT
cord-295807-68sukdb1	648	9	pH	ph	NN
cord-295807-68sukdb1	648	10	-	-	HYPH
cord-295807-68sukdb1	648	11	related	relate	VBN
cord-295807-68sukdb1	648	12	properties	property	NNS
cord-295807-68sukdb1	648	13	can	can	MD
cord-295807-68sukdb1	648	14	be	be	VB
cord-295807-68sukdb1	648	15	harnessed	harness	VBN
cord-295807-68sukdb1	648	16	to	to	IN
cord-295807-68sukdb1	648	17	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	648	18	advantage	advantage	NN
cord-295807-68sukdb1	648	19	,	,	,
cord-295807-68sukdb1	648	20	particularly	particularly	RB
cord-295807-68sukdb1	648	21	in	in	IN
cord-295807-68sukdb1	648	22	diseases	disease	NNS
cord-295807-68sukdb1	648	23	associated	associate	VBN
cord-295807-68sukdb1	648	24	with	with	IN
cord-295807-68sukdb1	648	25	acid	acid	NN
cord-295807-68sukdb1	648	26	-	-	HYPH
cord-295807-68sukdb1	648	27	base	base	NN
cord-295807-68sukdb1	648	28	imbalance	imbalance	NN
cord-295807-68sukdb1	648	29	.	.	.
cord-295807-68sukdb1	649	1	Oral	oral	JJ
cord-295807-68sukdb1	649	2	drug	drug	NN
cord-295807-68sukdb1	649	3	delivery	delivery	NN
cord-295807-68sukdb1	649	4	is	be	VBZ
cord-295807-68sukdb1	649	5	the	the	DT
cord-295807-68sukdb1	649	6	most	most	RBS
cord-295807-68sukdb1	649	7	common	common	JJ
cord-295807-68sukdb1	649	8	and	and	CC
cord-295807-68sukdb1	649	9	convenient	convenient	JJ
cord-295807-68sukdb1	649	10	method	method	NN
cord-295807-68sukdb1	649	11	used	use	VBN
cord-295807-68sukdb1	649	12	to	to	TO
cord-295807-68sukdb1	649	13	administer	administer	VB
cord-295807-68sukdb1	649	14	drugs	drug	NNS
cord-295807-68sukdb1	649	15	whereby	whereby	WRB
cord-295807-68sukdb1	649	16	they	-PRON-	PRP
cord-295807-68sukdb1	649	17	can	can	MD
cord-295807-68sukdb1	649	18	either	either	CC
cord-295807-68sukdb1	649	19	directly	directly	RB
cord-295807-68sukdb1	649	20	access	access	VB
cord-295807-68sukdb1	649	21	their	-PRON-	PRP$
cord-295807-68sukdb1	649	22	targets	target	NNS
cord-295807-68sukdb1	649	23	or	or	CC
cord-295807-68sukdb1	649	24	be	be	VB
cord-295807-68sukdb1	649	25	absorbed	absorb	VBN
cord-295807-68sukdb1	649	26	into	into	IN
cord-295807-68sukdb1	649	27	circulation	circulation	NN
cord-295807-68sukdb1	649	28	to	to	TO
cord-295807-68sukdb1	649	29	reach	reach	VB
cord-295807-68sukdb1	649	30	their	-PRON-	PRP$
cord-295807-68sukdb1	649	31	intended	intend	VBN
cord-295807-68sukdb1	649	32	targets	target	NNS
cord-295807-68sukdb1	649	33	.	.	.
cord-295807-68sukdb1	650	1	Thus	thus	RB
cord-295807-68sukdb1	650	2	,	,	,
cord-295807-68sukdb1	650	3	oral	oral	JJ
cord-295807-68sukdb1	650	4	drug	drug	NN
cord-295807-68sukdb1	650	5	delivery	delivery	NN
cord-295807-68sukdb1	650	6	will	will	MD
cord-295807-68sukdb1	650	7	serve	serve	VB
cord-295807-68sukdb1	650	8	as	as	IN
cord-295807-68sukdb1	650	9	our	-PRON-	PRP$
cord-295807-68sukdb1	650	10	paradigm	paradigm	NN
cord-295807-68sukdb1	650	11	for	for	IN
cord-295807-68sukdb1	650	12	discussion	discussion	NN
cord-295807-68sukdb1	650	13	.	.	.
cord-295807-68sukdb1	651	1	However	however	RB
cord-295807-68sukdb1	651	2	,	,	,
cord-295807-68sukdb1	651	3	these	these	DT
cord-295807-68sukdb1	651	4	concepts	concept	NNS
cord-295807-68sukdb1	651	5	are	be	VBP
cord-295807-68sukdb1	651	6	also	also	RB
cord-295807-68sukdb1	651	7	relevant	relevant	JJ
cord-295807-68sukdb1	651	8	to	to	IN
cord-295807-68sukdb1	651	9	other	other	JJ
cord-295807-68sukdb1	651	10	,	,	,
cord-295807-68sukdb1	651	11	parenteral	parenteral	JJ
cord-295807-68sukdb1	651	12	,	,	,
cord-295807-68sukdb1	651	13	methods	method	NNS
cord-295807-68sukdb1	651	14	of	of	IN
cord-295807-68sukdb1	651	15	drug	drug	NN
cord-295807-68sukdb1	651	16	delivery	delivery	NN
cord-295807-68sukdb1	651	17	such	such	JJ
cord-295807-68sukdb1	651	18	as	as	IN
cord-295807-68sukdb1	651	19	inhalation	inhalation	NN
cord-295807-68sukdb1	651	20	of	of	IN
cord-295807-68sukdb1	651	21	nebulized	nebulize	VBN
cord-295807-68sukdb1	651	22	substances	substance	NNS
cord-295807-68sukdb1	651	23	and	and	CC
cord-295807-68sukdb1	651	24	injection	injection	NN
cord-295807-68sukdb1	651	25	into	into	IN
cord-295807-68sukdb1	651	26	subcutaneous	subcutaneous	JJ
cord-295807-68sukdb1	651	27	,	,	,
cord-295807-68sukdb1	651	28	intramuscular	intramuscular	JJ
cord-295807-68sukdb1	651	29	,	,	,
cord-295807-68sukdb1	651	30	or	or	CC
cord-295807-68sukdb1	651	31	intravenous	intravenous	JJ
cord-295807-68sukdb1	651	32	compartments	compartment	NNS
cord-295807-68sukdb1	651	33	.	.	.
cord-295807-68sukdb1	652	1	Gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	652	2	(	(	-LRB-
cord-295807-68sukdb1	652	3	GI	GI	NNP
cord-295807-68sukdb1	652	4	)	)	-RRB-
cord-295807-68sukdb1	652	5	pH	ph	NN
cord-295807-68sukdb1	652	6	is	be	VBZ
cord-295807-68sukdb1	652	7	one	one	CD
cord-295807-68sukdb1	652	8	of	of	IN
cord-295807-68sukdb1	652	9	the	the	DT
cord-295807-68sukdb1	652	10	major	major	JJ
cord-295807-68sukdb1	652	11	determinants	determinant	NNS
cord-295807-68sukdb1	652	12	of	of	IN
cord-295807-68sukdb1	652	13	oral	oral	JJ
cord-295807-68sukdb1	652	14	drug	drug	NN
cord-295807-68sukdb1	652	15	bioavailability	bioavailability	NN
cord-295807-68sukdb1	652	16	as	as	IN
cord-295807-68sukdb1	652	17	it	-PRON-	PRP
cord-295807-68sukdb1	652	18	affects	affect	VBZ
cord-295807-68sukdb1	652	19	various	various	JJ
cord-295807-68sukdb1	652	20	properties	property	NNS
cord-295807-68sukdb1	652	21	including	include	VBG
cord-295807-68sukdb1	652	22	solubility	solubility	NN
cord-295807-68sukdb1	652	23	and	and	CC
cord-295807-68sukdb1	652	24	dissolution	dissolution	NN
cord-295807-68sukdb1	652	25	rate	rate	NN
cord-295807-68sukdb1	652	26	,	,	,
cord-295807-68sukdb1	652	27	stability	stability	NN
cord-295807-68sukdb1	652	28	,	,	,
cord-295807-68sukdb1	652	29	and	and	CC
cord-295807-68sukdb1	652	30	absorbability	absorbability	NN
cord-295807-68sukdb1	652	31	.	.	.
cord-295807-68sukdb1	653	1	pH	pH	NNP
cord-295807-68sukdb1	653	2	varies	vary	VBZ
cord-295807-68sukdb1	653	3	drastically	drastically	RB
cord-295807-68sukdb1	653	4	along	along	IN
cord-295807-68sukdb1	653	5	the	the	DT
cord-295807-68sukdb1	653	6	GI	GI	NNP
cord-295807-68sukdb1	653	7	tract	tract	NN
cord-295807-68sukdb1	653	8	[	[	-LRB-
cord-295807-68sukdb1	653	9	436	436	CD
cord-295807-68sukdb1	653	10	]	]	-RRB-
cord-295807-68sukdb1	653	11	[	[	-LRB-
cord-295807-68sukdb1	653	12	437	437	CD
cord-295807-68sukdb1	653	13	]	]	-RRB-
cord-295807-68sukdb1	653	14	[	[	-LRB-
cord-295807-68sukdb1	653	15	438	438	CD
cord-295807-68sukdb1	653	16	]	]	-RRB-
cord-295807-68sukdb1	653	17	.	.	.
cord-295807-68sukdb1	654	1	Starting	start	VBG
cord-295807-68sukdb1	654	2	from	from	IN
cord-295807-68sukdb1	654	3	a	a	DT
cord-295807-68sukdb1	654	4	value	value	NN
cord-295807-68sukdb1	654	5	of	of	IN
cord-295807-68sukdb1	654	6	~1.5	~1.5	CD
cord-295807-68sukdb1	654	7	in	in	IN
cord-295807-68sukdb1	654	8	the	the	DT
cord-295807-68sukdb1	654	9	stomach	stomach	NN
cord-295807-68sukdb1	654	10	,	,	,
cord-295807-68sukdb1	654	11	it	-PRON-	PRP
cord-295807-68sukdb1	654	12	rises	rise	VBZ
cord-295807-68sukdb1	654	13	to	to	IN
cord-295807-68sukdb1	654	14	~6.0	~6.0	CD
cord-295807-68sukdb1	654	15	in	in	IN
cord-295807-68sukdb1	654	16	the	the	DT
cord-295807-68sukdb1	654	17	duodenum	duodenum	NN
cord-295807-68sukdb1	654	18	,	,	,
cord-295807-68sukdb1	654	19	reaches	reach	VBZ
cord-295807-68sukdb1	654	20	~7.4	~7.4	CD
cord-295807-68sukdb1	654	21	in	in	IN
cord-295807-68sukdb1	654	22	the	the	DT
cord-295807-68sukdb1	654	23	terminal	terminal	JJ
cord-295807-68sukdb1	654	24	ileum	ileum	NN
cord-295807-68sukdb1	654	25	,	,	,
cord-295807-68sukdb1	654	26	and	and	CC
cord-295807-68sukdb1	654	27	falls	fall	VBZ
cord-295807-68sukdb1	654	28	again	again	RB
cord-295807-68sukdb1	654	29	to	to	IN
cord-295807-68sukdb1	654	30	~6.7	~6.7	CD
cord-295807-68sukdb1	654	31	in	in	IN
cord-295807-68sukdb1	654	32	the	the	DT
cord-295807-68sukdb1	654	33	colon	colon	NN
cord-295807-68sukdb1	654	34	[	[	-LRB-
cord-295807-68sukdb1	654	35	438	438	CD
cord-295807-68sukdb1	654	36	]	]	-RRB-
cord-295807-68sukdb1	654	37	.	.	.
cord-295807-68sukdb1	655	1	An	an	DT
cord-295807-68sukdb1	655	2	additional	additional	JJ
cord-295807-68sukdb1	655	3	consideration	consideration	NN
cord-295807-68sukdb1	655	4	is	be	VBZ
cord-295807-68sukdb1	655	5	that	that	IN
cord-295807-68sukdb1	655	6	these	these	DT
cord-295807-68sukdb1	655	7	values	value	NNS
cord-295807-68sukdb1	655	8	can	can	MD
cord-295807-68sukdb1	655	9	vary	vary	VB
cord-295807-68sukdb1	655	10	with	with	IN
cord-295807-68sukdb1	655	11	age	age	NN
cord-295807-68sukdb1	655	12	,	,	,
cord-295807-68sukdb1	655	13	presence	presence	NN
cord-295807-68sukdb1	655	14	of	of	IN
cord-295807-68sukdb1	655	15	food	food	NN
cord-295807-68sukdb1	655	16	,	,	,
cord-295807-68sukdb1	655	17	diseases	disease	NNS
cord-295807-68sukdb1	655	18	,	,	,
cord-295807-68sukdb1	655	19	and	and	CC
cord-295807-68sukdb1	655	20	also	also	RB
cord-295807-68sukdb1	655	21	by	by	IN
cord-295807-68sukdb1	655	22	the	the	DT
cord-295807-68sukdb1	655	23	co	co	NN
cord-295807-68sukdb1	655	24	-	-	NN
cord-295807-68sukdb1	655	25	administration	administration	NN
cord-295807-68sukdb1	655	26	of	of	IN
cord-295807-68sukdb1	655	27	other	other	JJ
cord-295807-68sukdb1	655	28	drugs	drug	NNS
cord-295807-68sukdb1	655	29	[	[	-LRB-
cord-295807-68sukdb1	655	30	439	439	CD
cord-295807-68sukdb1	655	31	]	]	-RRB-
cord-295807-68sukdb1	655	32	[	[	-LRB-
cord-295807-68sukdb1	655	33	440	440	CD
cord-295807-68sukdb1	655	34	]	]	-RRB-
cord-295807-68sukdb1	656	1	[	[	-LRB-
cord-295807-68sukdb1	656	2	441	441	CD
cord-295807-68sukdb1	656	3	]	]	-RRB-
cord-295807-68sukdb1	656	4	[	[	-LRB-
cord-295807-68sukdb1	656	5	442	442	CD
cord-295807-68sukdb1	656	6	]	]	-RRB-
cord-295807-68sukdb1	656	7	.	.	.
cord-295807-68sukdb1	657	1	Finally	finally	RB
cord-295807-68sukdb1	657	2	,	,	,
cord-295807-68sukdb1	657	3	we	-PRON-	PRP
cord-295807-68sukdb1	657	4	note	note	VBP
cord-295807-68sukdb1	657	5	that	that	IN
cord-295807-68sukdb1	657	6	the	the	DT
cord-295807-68sukdb1	657	7	influence	influence	NN
cord-295807-68sukdb1	657	8	of	of	IN
cord-295807-68sukdb1	657	9	pH	ph	NN
cord-295807-68sukdb1	657	10	on	on	IN
cord-295807-68sukdb1	657	11	bioavailability	bioavailability	NN
cord-295807-68sukdb1	657	12	could	could	MD
cord-295807-68sukdb1	657	13	,	,	,
cord-295807-68sukdb1	657	14	in	in	IN
cord-295807-68sukdb1	657	15	pH	ph	JJ
cord-295807-68sukdb1	657	16	-	-	HYPH
cord-295807-68sukdb1	657	17	disturbed	disturbed	JJ
cord-295807-68sukdb1	657	18	states	state	NNS
cord-295807-68sukdb1	657	19	,	,	,
cord-295807-68sukdb1	657	20	result	result	VB
cord-295807-68sukdb1	657	21	in	in	IN
cord-295807-68sukdb1	657	22	underdose	underdose	NN
cord-295807-68sukdb1	657	23	or	or	CC
cord-295807-68sukdb1	657	24	overdose	overdose	NN
cord-295807-68sukdb1	657	25	.	.	.
cord-295807-68sukdb1	658	1	Most	Most	JJS
cord-295807-68sukdb1	658	2	drugs	drug	NNS
cord-295807-68sukdb1	658	3	are	be	VBP
cord-295807-68sukdb1	658	4	weak	weak	JJ
cord-295807-68sukdb1	658	5	acids	acid	NNS
cord-295807-68sukdb1	658	6	and	and	CC
cord-295807-68sukdb1	658	7	bases	basis	NNS
cord-295807-68sukdb1	658	8	.	.	.
cord-295807-68sukdb1	659	1	The	the	DT
cord-295807-68sukdb1	659	2	relationship	relationship	NN
cord-295807-68sukdb1	659	3	between	between	IN
cord-295807-68sukdb1	659	4	the	the	DT
cord-295807-68sukdb1	659	5	drug	drug	NN
cord-295807-68sukdb1	659	6	ionization	ionization	NN
cord-295807-68sukdb1	659	7	constant	constant	JJ
cord-295807-68sukdb1	659	8	(	(	-LRB-
cord-295807-68sukdb1	659	9	pKa	pKa	NNP
cord-295807-68sukdb1	659	10	)	)	-RRB-
cord-295807-68sukdb1	659	11	and	and	CC
cord-295807-68sukdb1	659	12	the	the	DT
cord-295807-68sukdb1	659	13	pH	ph	NN
cord-295807-68sukdb1	659	14	of	of	IN
cord-295807-68sukdb1	659	15	the	the	DT
cord-295807-68sukdb1	659	16	environment	environment	NN
cord-295807-68sukdb1	659	17	to	to	TO
cord-295807-68sukdb1	659	18	which	which	WDT
cord-295807-68sukdb1	659	19	the	the	DT
cord-295807-68sukdb1	659	20	drug	drug	NN
cord-295807-68sukdb1	659	21	is	be	VBZ
cord-295807-68sukdb1	659	22	exposed	expose	VBN
cord-295807-68sukdb1	659	23	(	(	-LRB-
cord-295807-68sukdb1	659	24	hereafter	hereafter	RB
cord-295807-68sukdb1	659	25	referred	refer	VBN
cord-295807-68sukdb1	659	26	to	to	IN
cord-295807-68sukdb1	659	27	as	as	IN
cord-295807-68sukdb1	659	28	the	the	DT
cord-295807-68sukdb1	659	29	environmental	environmental	JJ
cord-295807-68sukdb1	659	30	pH	ph	NN
cord-295807-68sukdb1	659	31	)	)	-RRB-
cord-295807-68sukdb1	659	32	is	be	VBZ
cord-295807-68sukdb1	659	33	a	a	DT
cord-295807-68sukdb1	659	34	critical	critical	JJ
cord-295807-68sukdb1	659	35	determinant	determinant	NN
cord-295807-68sukdb1	659	36	of	of	IN
cord-295807-68sukdb1	659	37	drug	drug	NN
cord-295807-68sukdb1	659	38	solubility	solubility	NN
cord-295807-68sukdb1	659	39	and	and	CC
cord-295807-68sukdb1	659	40	dissolution	dissolution	NN
cord-295807-68sukdb1	659	41	rate	rate	NN
cord-295807-68sukdb1	659	42	in	in	IN
cord-295807-68sukdb1	659	43	aqueous	aqueous	JJ
cord-295807-68sukdb1	659	44	compartments	compartment	NNS
cord-295807-68sukdb1	659	45	[	[	-LRB-
cord-295807-68sukdb1	659	46	443	443	CD
cord-295807-68sukdb1	659	47	]	]	-RRB-
cord-295807-68sukdb1	659	48	.	.	.
cord-295807-68sukdb1	660	1	This	this	DT
cord-295807-68sukdb1	660	2	relationship	relationship	NN
cord-295807-68sukdb1	660	3	determines	determine	VBZ
cord-295807-68sukdb1	660	4	the	the	DT
cord-295807-68sukdb1	660	5	ratio	ratio	NN
cord-295807-68sukdb1	660	6	of	of	IN
cord-295807-68sukdb1	660	7	the	the	DT
cord-295807-68sukdb1	660	8	concentration	concentration	NN
cord-295807-68sukdb1	660	9	of	of	IN
cord-295807-68sukdb1	660	10	the	the	DT
cord-295807-68sukdb1	660	11	unionized	unionized	JJ
cord-295807-68sukdb1	660	12	(	(	-LRB-
cord-295807-68sukdb1	660	13	i.e.	i.e.	FW
cord-295807-68sukdb1	660	14	,	,	,
cord-295807-68sukdb1	660	15	uncharged	uncharged	JJ
cord-295807-68sukdb1	660	16	)	)	-RRB-
cord-295807-68sukdb1	660	17	form	form	NN
cord-295807-68sukdb1	660	18	(	(	-LRB-
cord-295807-68sukdb1	660	19	U	u	NN
cord-295807-68sukdb1	660	20	)	)	-RRB-
cord-295807-68sukdb1	660	21	to	to	IN
cord-295807-68sukdb1	660	22	the	the	DT
cord-295807-68sukdb1	660	23	concentration	concentration	NN
cord-295807-68sukdb1	660	24	of	of	IN
cord-295807-68sukdb1	660	25	the	the	DT
cord-295807-68sukdb1	660	26	ionized	ionized	JJ
cord-295807-68sukdb1	660	27	(	(	-LRB-
cord-295807-68sukdb1	660	28	i.e.	i.e.	FW
cord-295807-68sukdb1	660	29	,	,	,
cord-295807-68sukdb1	660	30	charged	charge	VBN
cord-295807-68sukdb1	660	31	)	)	-RRB-
cord-295807-68sukdb1	660	32	form	form	NN
cord-295807-68sukdb1	660	33	(	(	-LRB-
cord-295807-68sukdb1	660	34	I	i	NN
cord-295807-68sukdb1	660	35	)	)	-RRB-
cord-295807-68sukdb1	660	36	of	of	IN
cord-295807-68sukdb1	660	37	the	the	DT
cord-295807-68sukdb1	660	38	drug	drug	NN
cord-295807-68sukdb1	660	39	and	and	CC
cord-295807-68sukdb1	660	40	is	be	VBZ
cord-295807-68sukdb1	660	41	described	describe	VBN
cord-295807-68sukdb1	660	42	by	by	IN
cord-295807-68sukdb1	660	43	the	the	DT
cord-295807-68sukdb1	660	44	Henderson	Henderson	NNP
cord-295807-68sukdb1	660	45	-	-	HYPH
cord-295807-68sukdb1	660	46	Hasselbalch	Hasselbalch	NNP
cord-295807-68sukdb1	660	47	equation	equation	NN
cord-295807-68sukdb1	660	48	.	.	.
cord-295807-68sukdb1	661	1	Now	now	RB
cord-295807-68sukdb1	661	2	,	,	,
cord-295807-68sukdb1	661	3	according	accord	VBG
cord-295807-68sukdb1	661	4	to	to	IN
cord-295807-68sukdb1	661	5	equation	equation	NN
cord-295807-68sukdb1	661	6	(	(	-LRB-
cord-295807-68sukdb1	661	7	5	5	CD
cord-295807-68sukdb1	661	8	)	)	-RRB-
cord-295807-68sukdb1	661	9	,	,	,
cord-295807-68sukdb1	661	10	3	3	CD
cord-295807-68sukdb1	661	11	.	.	.
cord-295807-68sukdb1	662	1	if	if	IN
cord-295807-68sukdb1	662	2	pH	pH	NNP
cord-295807-68sukdb1	662	3	<	<	XX
cord-295807-68sukdb1	662	4	pKa	pKa	NNP
cord-295807-68sukdb1	662	5	(	(	-LRB-
cord-295807-68sukdb1	662	6	i.e.	i.e.	FW
cord-295807-68sukdb1	662	7	,	,	,
cord-295807-68sukdb1	662	8	10	10	CD
cord-295807-68sukdb1	662	9	pH−pKa	ph−pka	NN
cord-295807-68sukdb1	662	10	<	<	XX
cord-295807-68sukdb1	662	11	1	1	CD
cord-295807-68sukdb1	662	12	)	)	-RRB-
cord-295807-68sukdb1	662	13	,	,	,
cord-295807-68sukdb1	662	14	the	the	DT
cord-295807-68sukdb1	662	15	ionized	ionized	JJ
cord-295807-68sukdb1	662	16	form	form	NN
cord-295807-68sukdb1	662	17	I	-PRON-	PRP
cord-295807-68sukdb1	662	18	(	(	-LRB-
cord-295807-68sukdb1	662	19	i.e.	i.e.	FW
cord-295807-68sukdb1	662	20	,	,	,
cord-295807-68sukdb1	662	21	the	the	DT
cord-295807-68sukdb1	662	22	acidic	acidic	JJ
cord-295807-68sukdb1	662	23	conjugate	conjugate	JJ
cord-295807-68sukdb1	662	24	weak	weak	JJ
cord-295807-68sukdb1	662	25	base	base	NN
cord-295807-68sukdb1	662	26	BH	BH	NNP
cord-295807-68sukdb1	662	27	+	+	CC
cord-295807-68sukdb1	662	28	)	)	-RRB-
cord-295807-68sukdb1	662	29	prevails	prevail	VBZ
cord-295807-68sukdb1	662	30	;	;	:
cord-295807-68sukdb1	662	31	4	4	CD
cord-295807-68sukdb1	662	32	.	.	.
cord-295807-68sukdb1	663	1	if	if	IN
cord-295807-68sukdb1	664	1	pH	pH	NNP
cord-295807-68sukdb1	664	2	>	>	XX
cord-295807-68sukdb1	665	1	pKa	pKa	NNP
cord-295807-68sukdb1	665	2	(	(	-LRB-
cord-295807-68sukdb1	665	3	i.e.	i.e.	FW
cord-295807-68sukdb1	665	4	,	,	,
cord-295807-68sukdb1	665	5	10	10	CD
cord-295807-68sukdb1	665	6	pKa−pH	pKa−pH	NNS
cord-295807-68sukdb1	665	7	>	>	XX
cord-295807-68sukdb1	665	8	1	1	CD
cord-295807-68sukdb1	665	9	)	)	-RRB-
cord-295807-68sukdb1	665	10	,	,	,
cord-295807-68sukdb1	665	11	the	the	DT
cord-295807-68sukdb1	665	12	unionized	unionized	JJ
cord-295807-68sukdb1	665	13	form	form	NN
cord-295807-68sukdb1	665	14	U	u	NN
cord-295807-68sukdb1	665	15	(	(	-LRB-
cord-295807-68sukdb1	665	16	i.e.	i.e.	FW
cord-295807-68sukdb1	665	17	,	,	,
cord-295807-68sukdb1	665	18	the	the	DT
cord-295807-68sukdb1	665	19	basic	basic	JJ
cord-295807-68sukdb1	665	20	neutral	neutral	NN
cord-295807-68sukdb1	665	21	for	for	IN
cord-295807-68sukdb1	665	22	B	b	NN
cord-295807-68sukdb1	665	23	)	)	-RRB-
cord-295807-68sukdb1	665	24	prevails	prevail	VBZ
cord-295807-68sukdb1	665	25	.	.	.
cord-295807-68sukdb1	666	1	Thus	thus	RB
cord-295807-68sukdb1	666	2	,	,	,
cord-295807-68sukdb1	666	3	because	because	IN
cord-295807-68sukdb1	666	4	the	the	DT
cord-295807-68sukdb1	666	5	ionized	ionized	JJ
cord-295807-68sukdb1	666	6	form	form	NN
cord-295807-68sukdb1	666	7	I	-PRON-	PRP
cord-295807-68sukdb1	666	8	is	be	VBZ
cord-295807-68sukdb1	666	9	more	more	JJR
cord-295807-68sukdb1	666	10	water	water	NN
cord-295807-68sukdb1	666	11	-	-	HYPH
cord-295807-68sukdb1	666	12	soluble	soluble	JJ
cord-295807-68sukdb1	666	13	than	than	IN
cord-295807-68sukdb1	666	14	the	the	DT
cord-295807-68sukdb1	666	15	unionized	unionized	JJ
cord-295807-68sukdb1	666	16	form	form	NN
cord-295807-68sukdb1	666	17	(	(	-LRB-
cord-295807-68sukdb1	666	18	due	due	IN
cord-295807-68sukdb1	666	19	to	to	IN
cord-295807-68sukdb1	666	20	better	well	JJR
cord-295807-68sukdb1	666	21	solvation	solvation	NN
cord-295807-68sukdb1	666	22	between	between	IN
cord-295807-68sukdb1	666	23	the	the	DT
cord-295807-68sukdb1	666	24	ionized	ionized	JJ
cord-295807-68sukdb1	666	25	form	form	NN
cord-295807-68sukdb1	667	1	I	-PRON-	PRP
cord-295807-68sukdb1	667	2	and	and	CC
cord-295807-68sukdb1	667	3	the	the	DT
cord-295807-68sukdb1	667	4	dipole	dipole	NN
cord-295807-68sukdb1	667	5	of	of	IN
cord-295807-68sukdb1	667	6	the	the	DT
cord-295807-68sukdb1	667	7	water	water	NN
cord-295807-68sukdb1	667	8	molecule	molecule	NN
cord-295807-68sukdb1	667	9	)	)	-RRB-
cord-295807-68sukdb1	667	10	,	,	,
cord-295807-68sukdb1	667	11	weakly	weakly	RB
cord-295807-68sukdb1	667	12	acidic	acidic	JJ
cord-295807-68sukdb1	667	13	drugs	drug	NNS
cord-295807-68sukdb1	667	14	have	have	VBP
cord-295807-68sukdb1	667	15	higher	high	JJR
cord-295807-68sukdb1	667	16	solubility	solubility	NN
cord-295807-68sukdb1	667	17	at	at	IN
cord-295807-68sukdb1	667	18	high	high	JJ
cord-295807-68sukdb1	667	19	pH	ph	NN
cord-295807-68sukdb1	667	20	whereas	whereas	IN
cord-295807-68sukdb1	667	21	weakly	weakly	RB
cord-295807-68sukdb1	667	22	basic	basic	JJ
cord-295807-68sukdb1	667	23	drugs	drug	NNS
cord-295807-68sukdb1	667	24	have	have	VBP
cord-295807-68sukdb1	667	25	higher	high	JJR
cord-295807-68sukdb1	667	26	solubility	solubility	NN
cord-295807-68sukdb1	667	27	at	at	IN
cord-295807-68sukdb1	667	28	low	low	JJ
cord-295807-68sukdb1	667	29	pH.	ph.	NN
cord-295807-68sukdb1	668	1	This	this	DT
cord-295807-68sukdb1	668	2	means	mean	VBZ
cord-295807-68sukdb1	668	3	that	that	IN
cord-295807-68sukdb1	668	4	weakly	weakly	RB
cord-295807-68sukdb1	668	5	acidic	acidic	JJ
cord-295807-68sukdb1	668	6	drugs	drug	NNS
cord-295807-68sukdb1	668	7	tend	tend	VBP
cord-295807-68sukdb1	668	8	to	to	TO
cord-295807-68sukdb1	668	9	dissolve	dissolve	VB
cord-295807-68sukdb1	668	10	more	more	RBR
cord-295807-68sukdb1	668	11	easily	easily	RB
cord-295807-68sukdb1	668	12	in	in	IN
cord-295807-68sukdb1	668	13	the	the	DT
cord-295807-68sukdb1	668	14	intestine	intestine	NN
cord-295807-68sukdb1	668	15	whereas	whereas	IN
cord-295807-68sukdb1	668	16	weakly	weakly	RB
cord-295807-68sukdb1	668	17	basic	basic	JJ
cord-295807-68sukdb1	668	18	drugs	drug	NNS
cord-295807-68sukdb1	668	19	tend	tend	VBP
cord-295807-68sukdb1	668	20	to	to	TO
cord-295807-68sukdb1	668	21	dissolve	dissolve	VB
cord-295807-68sukdb1	668	22	more	more	RBR
cord-295807-68sukdb1	668	23	easily	easily	RB
cord-295807-68sukdb1	668	24	in	in	IN
cord-295807-68sukdb1	668	25	the	the	DT
cord-295807-68sukdb1	668	26	stomach	stomach	NN
cord-295807-68sukdb1	668	27	.	.	.
cord-295807-68sukdb1	669	1	Because	because	IN
cord-295807-68sukdb1	669	2	drug	drug	NN
cord-295807-68sukdb1	669	3	solubility	solubility	NN
cord-295807-68sukdb1	669	4	is	be	VBZ
cord-295807-68sukdb1	669	5	pH	ph	NN
cord-295807-68sukdb1	669	6	-	-	HYPH
cord-295807-68sukdb1	669	7	dependent	dependent	JJ
cord-295807-68sukdb1	669	8	,	,	,
cord-295807-68sukdb1	669	9	the	the	DT
cord-295807-68sukdb1	669	10	dissolution	dissolution	NN
cord-295807-68sukdb1	669	11	profile	profile	NN
cord-295807-68sukdb1	669	12	of	of	IN
cord-295807-68sukdb1	669	13	the	the	DT
cord-295807-68sukdb1	669	14	drug	drug	NN
cord-295807-68sukdb1	669	15	(	(	-LRB-
cord-295807-68sukdb1	669	16	i.e.	i.e.	FW
cord-295807-68sukdb1	669	17	,	,	,
cord-295807-68sukdb1	669	18	the	the	DT
cord-295807-68sukdb1	669	19	process	process	NN
cord-295807-68sukdb1	669	20	by	by	IN
cord-295807-68sukdb1	669	21	which	which	WDT
cord-295807-68sukdb1	669	22	a	a	DT
cord-295807-68sukdb1	669	23	solid	solid	JJ
cord-295807-68sukdb1	669	24	drug	drug	NN
cord-295807-68sukdb1	669	25	dissolves	dissolve	VBZ
cord-295807-68sukdb1	669	26	into	into	IN
cord-295807-68sukdb1	669	27	solution	solution	NN
cord-295807-68sukdb1	669	28	)	)	-RRB-
cord-295807-68sukdb1	669	29	may	may	MD
cord-295807-68sukdb1	669	30	also	also	RB
cord-295807-68sukdb1	669	31	be	be	VB
cord-295807-68sukdb1	669	32	pH	ph	NN
cord-295807-68sukdb1	669	33	-	-	HYPH
cord-295807-68sukdb1	669	34	dependent	dependent	JJ
cord-295807-68sukdb1	669	35	[	[	-LRB-
cord-295807-68sukdb1	669	36	440	440	CD
cord-295807-68sukdb1	669	37	,	,	,
cord-295807-68sukdb1	669	38	443	443	CD
cord-295807-68sukdb1	669	39	]	]	-RRB-
cord-295807-68sukdb1	669	40	.	.	.
cord-295807-68sukdb1	670	1	Drug	drug	NN
cord-295807-68sukdb1	670	2	solubility	solubility	NN
cord-295807-68sukdb1	670	3	and	and	CC
cord-295807-68sukdb1	670	4	dissolution	dissolution	NN
cord-295807-68sukdb1	670	5	may	may	MD
cord-295807-68sukdb1	670	6	be	be	VB
cord-295807-68sukdb1	670	7	enhanced	enhance	VBN
cord-295807-68sukdb1	670	8	by	by	IN
cord-295807-68sukdb1	670	9	several	several	JJ
cord-295807-68sukdb1	670	10	techniques	technique	NNS
cord-295807-68sukdb1	670	11	including	include	VBG
cord-295807-68sukdb1	670	12	(	(	-LRB-
cord-295807-68sukdb1	670	13	i	i	NN
cord-295807-68sukdb1	670	14	)	)	-RRB-
cord-295807-68sukdb1	670	15	chemical	chemical	NN
cord-295807-68sukdb1	670	16	derivatization	derivatization	NN
cord-295807-68sukdb1	670	17	to	to	TO
cord-295807-68sukdb1	670	18	alter	alter	VB
cord-295807-68sukdb1	670	19	drug	drug	NN
cord-295807-68sukdb1	670	20	pKa	pKa	NNP
cord-295807-68sukdb1	670	21	,	,	,
cord-295807-68sukdb1	670	22	(	(	-LRB-
cord-295807-68sukdb1	670	23	ii	ii	NN
cord-295807-68sukdb1	670	24	)	)	-RRB-
cord-295807-68sukdb1	670	25	administration	administration	NN
cord-295807-68sukdb1	670	26	of	of	IN
cord-295807-68sukdb1	670	27	the	the	DT
cord-295807-68sukdb1	670	28	drug	drug	NN
cord-295807-68sukdb1	670	29	in	in	IN
cord-295807-68sukdb1	670	30	ionic	ionic	JJ
cord-295807-68sukdb1	670	31	form	form	NN
cord-295807-68sukdb1	670	32	(	(	-LRB-
cord-295807-68sukdb1	670	33	as	as	IN
cord-295807-68sukdb1	670	34	a	a	DT
cord-295807-68sukdb1	670	35	salt	salt	NN
cord-295807-68sukdb1	670	36	)	)	-RRB-
cord-295807-68sukdb1	670	37	rather	rather	RB
cord-295807-68sukdb1	670	38	than	than	IN
cord-295807-68sukdb1	670	39	as	as	IN
cord-295807-68sukdb1	670	40	a	a	DT
cord-295807-68sukdb1	670	41	free	free	JJ
cord-295807-68sukdb1	670	42	acid	acid	NN
cord-295807-68sukdb1	670	43	or	or	CC
cord-295807-68sukdb1	670	44	base	base	NN
cord-295807-68sukdb1	670	45	,	,	,
cord-295807-68sukdb1	670	46	or	or	CC
cord-295807-68sukdb1	670	47	(	(	-LRB-
cord-295807-68sukdb1	670	48	iii	iii	NN
cord-295807-68sukdb1	670	49	)	)	-RRB-
cord-295807-68sukdb1	670	50	alteration	alteration	NN
cord-295807-68sukdb1	670	51	of	of	IN
cord-295807-68sukdb1	670	52	environmental	environmental	JJ
cord-295807-68sukdb1	670	53	pH	ph	NN
cord-295807-68sukdb1	670	54	by	by	IN
cord-295807-68sukdb1	670	55	the	the	DT
cord-295807-68sukdb1	670	56	adjuvant	adjuvant	JJ
cord-295807-68sukdb1	670	57	use	use	NN
cord-295807-68sukdb1	670	58	of	of	IN
cord-295807-68sukdb1	670	59	acids	acid	NNS
cord-295807-68sukdb1	670	60	or	or	CC
cord-295807-68sukdb1	670	61	bases	basis	NNS
cord-295807-68sukdb1	670	62	to	to	TO
cord-295807-68sukdb1	670	63	better	better	RB
cord-295807-68sukdb1	670	64	match	match	VB
cord-295807-68sukdb1	670	65	the	the	DT
cord-295807-68sukdb1	670	66	drug	drug	NN
cord-295807-68sukdb1	670	67	's	's	POS
cord-295807-68sukdb1	670	68	pKa	pKa	NNPS
cord-295807-68sukdb1	670	69	[	[	-LRB-
cord-295807-68sukdb1	670	70	444	444	CD
cord-295807-68sukdb1	670	71	]	]	-RRB-
cord-295807-68sukdb1	670	72	[	[	-LRB-
cord-295807-68sukdb1	670	73	445	445	CD
cord-295807-68sukdb1	670	74	]	]	-RRB-
cord-295807-68sukdb1	670	75	[	[	-LRB-
cord-295807-68sukdb1	670	76	446	446	CD
cord-295807-68sukdb1	670	77	]	]	-RRB-
cord-295807-68sukdb1	670	78	.	.	.
cord-295807-68sukdb1	671	1	In	in	IN
cord-295807-68sukdb1	671	2	some	some	DT
cord-295807-68sukdb1	671	3	cases	case	NNS
cord-295807-68sukdb1	671	4	,	,	,
cord-295807-68sukdb1	671	5	it	-PRON-	PRP
cord-295807-68sukdb1	671	6	may	may	MD
cord-295807-68sukdb1	671	7	be	be	VB
cord-295807-68sukdb1	671	8	desirable	desirable	JJ
cord-295807-68sukdb1	671	9	to	to	TO
cord-295807-68sukdb1	671	10	lower	lower	VB
cord-295807-68sukdb1	671	11	the	the	DT
cord-295807-68sukdb1	671	12	solubility	solubility	NN
cord-295807-68sukdb1	671	13	and	and	CC
cord-295807-68sukdb1	671	14	dissolution	dissolution	NN
cord-295807-68sukdb1	671	15	of	of	IN
cord-295807-68sukdb1	671	16	parenterally	parenterally	RB
cord-295807-68sukdb1	671	17	-	-	HYPH
cord-295807-68sukdb1	671	18	administered	administer	VBN
cord-295807-68sukdb1	671	19	drugs	drug	NNS
cord-295807-68sukdb1	671	20	in	in	IN
cord-295807-68sukdb1	671	21	order	order	NN
cord-295807-68sukdb1	671	22	to	to	TO
cord-295807-68sukdb1	671	23	prolong	prolong	VB
cord-295807-68sukdb1	671	24	their	-PRON-	PRP$
cord-295807-68sukdb1	671	25	half	half	JJ
cord-295807-68sukdb1	671	26	-	-	HYPH
cord-295807-68sukdb1	671	27	life	life	NN
cord-295807-68sukdb1	671	28	.	.	.
cord-295807-68sukdb1	672	1	As	as	IN
cord-295807-68sukdb1	672	2	we	-PRON-	PRP
cord-295807-68sukdb1	672	3	discuss	discuss	VBP
cord-295807-68sukdb1	672	4	in	in	IN
cord-295807-68sukdb1	672	5	the	the	DT
cord-295807-68sukdb1	672	6	next	next	JJ
cord-295807-68sukdb1	672	7	section	section	NN
cord-295807-68sukdb1	672	8	,	,	,
cord-295807-68sukdb1	672	9	the	the	DT
cord-295807-68sukdb1	672	10	influence	influence	NN
cord-295807-68sukdb1	672	11	of	of	IN
cord-295807-68sukdb1	672	12	drug	drug	NN
cord-295807-68sukdb1	672	13	pKa	pKa	NNPS
cord-295807-68sukdb1	672	14	and	and	CC
cord-295807-68sukdb1	672	15	environmental	environmental	JJ
cord-295807-68sukdb1	672	16	pH	ph	NN
cord-295807-68sukdb1	672	17	on	on	IN
cord-295807-68sukdb1	672	18	drug	drug	NN
cord-295807-68sukdb1	672	19	ionization	ionization	NN
cord-295807-68sukdb1	672	20	has	have	VBZ
cord-295807-68sukdb1	672	21	important	important	JJ
cord-295807-68sukdb1	672	22	ramifications	ramification	NNS
cord-295807-68sukdb1	672	23	for	for	IN
cord-295807-68sukdb1	672	24	drug	drug	NN
cord-295807-68sukdb1	672	25	absorption	absorption	NN
cord-295807-68sukdb1	672	26	and	and	CC
cord-295807-68sukdb1	672	27	distribution	distribution	NN
cord-295807-68sukdb1	672	28	.	.	.
cord-295807-68sukdb1	673	1	Besides	besides	IN
cord-295807-68sukdb1	673	2	solubility	solubility	NN
cord-295807-68sukdb1	673	3	in	in	IN
cord-295807-68sukdb1	673	4	aqueous	aqueous	JJ
cord-295807-68sukdb1	673	5	solvent	solvent	NN
cord-295807-68sukdb1	673	6	,	,	,
cord-295807-68sukdb1	673	7	the	the	DT
cord-295807-68sukdb1	673	8	ionization	ionization	NN
cord-295807-68sukdb1	673	9	state	state	NN
cord-295807-68sukdb1	673	10	of	of	IN
cord-295807-68sukdb1	673	11	a	a	DT
cord-295807-68sukdb1	673	12	drug	drug	NN
cord-295807-68sukdb1	673	13	can	can	MD
cord-295807-68sukdb1	673	14	influence	influence	VB
cord-295807-68sukdb1	673	15	its	-PRON-	PRP$
cord-295807-68sukdb1	673	16	solubility	solubility	NN
cord-295807-68sukdb1	673	17	in	in	IN
cord-295807-68sukdb1	673	18	the	the	DT
cord-295807-68sukdb1	673	19	lipid	lipid	NN
cord-295807-68sukdb1	673	20	phase	phase	NN
cord-295807-68sukdb1	673	21	(	(	-LRB-
cord-295807-68sukdb1	673	22	e.g.	e.g.	RB
cord-295807-68sukdb1	673	23	,	,	,
cord-295807-68sukdb1	673	24	drug	drug	NN
cord-295807-68sukdb1	673	25	pKa	pKa	NNPS
cord-295807-68sukdb1	673	26	can	can	MD
cord-295807-68sukdb1	673	27	be	be	VB
cord-295807-68sukdb1	673	28	modified	modify	VBN
cord-295807-68sukdb1	673	29	to	to	TO
cord-295807-68sukdb1	673	30	increase	increase	VB
cord-295807-68sukdb1	673	31	drug	drug	NN
cord-295807-68sukdb1	673	32	polarity	polarity	NN
cord-295807-68sukdb1	673	33	and	and	CC
cord-295807-68sukdb1	673	34	therefore	therefore	RB
cord-295807-68sukdb1	673	35	reduce	reduce	VB
cord-295807-68sukdb1	673	36	drug	drug	NN
cord-295807-68sukdb1	673	37	lipophilicity	lipophilicity	NN
cord-295807-68sukdb1	673	38	)	)	-RRB-
cord-295807-68sukdb1	673	39	and	and	CC
cord-295807-68sukdb1	673	40	therefore	therefore	RB
cord-295807-68sukdb1	673	41	affect	affect	VB
cord-295807-68sukdb1	673	42	its	-PRON-	PRP$
cord-295807-68sukdb1	673	43	ability	ability	NN
cord-295807-68sukdb1	673	44	to	to	TO
cord-295807-68sukdb1	673	45	permeate	permeate	VB
cord-295807-68sukdb1	673	46	cell	cell	NN
cord-295807-68sukdb1	673	47	membranes	membrane	NNS
cord-295807-68sukdb1	673	48	[	[	-LRB-
cord-295807-68sukdb1	673	49	444	444	CD
cord-295807-68sukdb1	673	50	,	,	,
cord-295807-68sukdb1	673	51	447	447	CD
cord-295807-68sukdb1	673	52	]	]	-RRB-
cord-295807-68sukdb1	673	53	.	.	.
cord-295807-68sukdb1	674	1	Assuming	assume	VBG
cord-295807-68sukdb1	674	2	that	that	DT
cord-295807-68sukdb1	674	3	passive	passive	JJ
cord-295807-68sukdb1	674	4	diffusion	diffusion	NN
cord-295807-68sukdb1	674	5	(	(	-LRB-
cord-295807-68sukdb1	674	6	i.e.	i.e.	FW
cord-295807-68sukdb1	674	7	,	,	,
cord-295807-68sukdb1	674	8	transmembrane	transmembrane	NN
cord-295807-68sukdb1	674	9	concentration	concentration	NN
cord-295807-68sukdb1	674	10	gradient	gradient	NN
cord-295807-68sukdb1	674	11	is	be	VBZ
cord-295807-68sukdb1	674	12	the	the	DT
cord-295807-68sukdb1	674	13	driving	drive	VBG
cord-295807-68sukdb1	674	14	force	force	NN
cord-295807-68sukdb1	674	15	)	)	-RRB-
cord-295807-68sukdb1	674	16	is	be	VBZ
cord-295807-68sukdb1	674	17	the	the	DT
cord-295807-68sukdb1	674	18	mechanism	mechanism	NN
cord-295807-68sukdb1	674	19	by	by	IN
cord-295807-68sukdb1	674	20	which	which	WDT
cord-295807-68sukdb1	674	21	a	a	DT
cord-295807-68sukdb1	674	22	drug	drug	NN
cord-295807-68sukdb1	674	23	moves	move	VBZ
cord-295807-68sukdb1	674	24	across	across	IN
cord-295807-68sukdb1	674	25	a	a	DT
cord-295807-68sukdb1	674	26	membrane	membrane	NN
cord-295807-68sukdb1	674	27	and	and	CC
cord-295807-68sukdb1	674	28	that	that	IN
cord-295807-68sukdb1	674	29	only	only	JJ
cord-295807-68sukdb1	674	30	uncharged	uncharged	JJ
cord-295807-68sukdb1	674	31	ions	ion	NNS
cord-295807-68sukdb1	674	32	can	can	MD
cord-295807-68sukdb1	674	33	freely	freely	RB
cord-295807-68sukdb1	674	34	diffuse	diffuse	VB
cord-295807-68sukdb1	674	35	across	across	IN
cord-295807-68sukdb1	674	36	the	the	DT
cord-295807-68sukdb1	674	37	membrane	membrane	NN
cord-295807-68sukdb1	674	38	,	,	,
cord-295807-68sukdb1	674	39	we	-PRON-	PRP
cord-295807-68sukdb1	674	40	can	can	MD
cord-295807-68sukdb1	674	41	turn	turn	VB
cord-295807-68sukdb1	674	42	again	again	RB
cord-295807-68sukdb1	674	43	to	to	IN
cord-295807-68sukdb1	674	44	the	the	DT
cord-295807-68sukdb1	674	45	Henderson	Henderson	NNP
cord-295807-68sukdb1	674	46	-	-	HYPH
cord-295807-68sukdb1	674	47	Hasselbalch	Hasselbalch	NNP
cord-295807-68sukdb1	674	48	equation	equation	NN
cord-295807-68sukdb1	674	49	to	to	TO
cord-295807-68sukdb1	674	50	describe	describe	VB
cord-295807-68sukdb1	674	51	the	the	DT
cord-295807-68sukdb1	674	52	importance	importance	NN
cord-295807-68sukdb1	674	53	of	of	IN
cord-295807-68sukdb1	674	54	drug	drug	NN
cord-295807-68sukdb1	674	55	pKa	pKa	NNPS
cord-295807-68sukdb1	674	56	and	and	CC
cord-295807-68sukdb1	674	57	environmental	environmental	JJ
cord-295807-68sukdb1	674	58	pH	ph	NN
cord-295807-68sukdb1	674	59	to	to	IN
cord-295807-68sukdb1	674	60	drug	drug	NN
cord-295807-68sukdb1	674	61	absorption	absorption	NN
cord-295807-68sukdb1	674	62	and	and	CC
cord-295807-68sukdb1	674	63	distribution	distribution	NN
cord-295807-68sukdb1	674	64	between	between	IN
cord-295807-68sukdb1	674	65	body	body	NN
cord-295807-68sukdb1	674	66	compartments	compartment	NNS
cord-295807-68sukdb1	674	67	.	.	.
cord-295807-68sukdb1	675	1	We	-PRON-	PRP
cord-295807-68sukdb1	675	2	note	note	VBP
cord-295807-68sukdb1	675	3	that	that	IN
cord-295807-68sukdb1	675	4	,	,	,
cord-295807-68sukdb1	675	5	according	accord	VBG
cord-295807-68sukdb1	675	6	to	to	IN
cord-295807-68sukdb1	675	7	point	point	NN
cord-295807-68sukdb1	675	8	1	1	CD
cord-295807-68sukdb1	675	9	)	)	-RRB-
cord-295807-68sukdb1	675	10	above	above	RB
cord-295807-68sukdb1	675	11	,	,	,
cord-295807-68sukdb1	675	12	the	the	DT
cord-295807-68sukdb1	675	13	Henderson	Henderson	NNP
cord-295807-68sukdb1	675	14	-	-	HYPH
cord-295807-68sukdb1	675	15	Hasselbalch	Hasselbalch	NNP
cord-295807-68sukdb1	675	16	equation	equation	NN
cord-295807-68sukdb1	675	17	predicts	predict	VBZ
cord-295807-68sukdb1	675	18	that	that	IN
cord-295807-68sukdb1	675	19	weak	weak	JJ
cord-295807-68sukdb1	675	20	acids	acid	NNS
cord-295807-68sukdb1	675	21	tend	tend	VBP
cord-295807-68sukdb1	675	22	to	to	TO
cord-295807-68sukdb1	675	23	be	be	VB
cord-295807-68sukdb1	675	24	absorbed	absorb	VBN
cord-295807-68sukdb1	675	25	in	in	IN
cord-295807-68sukdb1	675	26	an	an	DT
cord-295807-68sukdb1	675	27	acidic	acidic	JJ
cord-295807-68sukdb1	675	28	environment	environment	NN
cord-295807-68sukdb1	675	29	(	(	-LRB-
cord-295807-68sukdb1	675	30	e.g.	e.g.	RB
cord-295807-68sukdb1	675	31	,	,	,
cord-295807-68sukdb1	675	32	in	in	IN
cord-295807-68sukdb1	675	33	the	the	DT
cord-295807-68sukdb1	675	34	stomach	stomach	NN
cord-295807-68sukdb1	675	35	)	)	-RRB-
cord-295807-68sukdb1	675	36	.	.	.
cord-295807-68sukdb1	676	1	Similarly	similarly	RB
cord-295807-68sukdb1	676	2	,	,	,
cord-295807-68sukdb1	676	3	according	accord	VBG
cord-295807-68sukdb1	676	4	to	to	IN
cord-295807-68sukdb1	676	5	point	point	NN
cord-295807-68sukdb1	676	6	4	4	CD
cord-295807-68sukdb1	676	7	)	)	-RRB-
cord-295807-68sukdb1	676	8	above	above	RB
cord-295807-68sukdb1	676	9	,	,	,
cord-295807-68sukdb1	676	10	the	the	DT
cord-295807-68sukdb1	676	11	Henderson	Henderson	NNP
cord-295807-68sukdb1	676	12	-	-	HYPH
cord-295807-68sukdb1	676	13	Hasselbalch	Hasselbalch	NNP
cord-295807-68sukdb1	676	14	equation	equation	NN
cord-295807-68sukdb1	676	15	predicts	predict	VBZ
cord-295807-68sukdb1	676	16	that	that	IN
cord-295807-68sukdb1	676	17	weak	weak	JJ
cord-295807-68sukdb1	676	18	bases	basis	NNS
cord-295807-68sukdb1	676	19	tend	tend	VBP
cord-295807-68sukdb1	676	20	to	to	TO
cord-295807-68sukdb1	676	21	be	be	VB
cord-295807-68sukdb1	676	22	absorbed	absorb	VBN
cord-295807-68sukdb1	676	23	in	in	IN
cord-295807-68sukdb1	676	24	a	a	DT
cord-295807-68sukdb1	676	25	basic	basic	JJ
cord-295807-68sukdb1	676	26	environment	environment	NN
cord-295807-68sukdb1	676	27	(	(	-LRB-
cord-295807-68sukdb1	676	28	e.g.	e.g.	RB
cord-295807-68sukdb1	676	29	,	,	,
cord-295807-68sukdb1	676	30	in	in	IN
cord-295807-68sukdb1	676	31	the	the	DT
cord-295807-68sukdb1	676	32	small	small	JJ
cord-295807-68sukdb1	676	33	intestine	intestine	NN
cord-295807-68sukdb1	676	34	)	)	-RRB-
cord-295807-68sukdb1	676	35	.	.	.
cord-295807-68sukdb1	677	1	In	in	IN
cord-295807-68sukdb1	677	2	1957	1957	CD
cord-295807-68sukdb1	677	3	,	,	,
cord-295807-68sukdb1	677	4	Shore	Shore	NNP
cord-295807-68sukdb1	677	5	and	and	CC
cord-295807-68sukdb1	677	6	coworkers	coworker	NNS
cord-295807-68sukdb1	677	7	proposed	propose	VBD
cord-295807-68sukdb1	677	8	the	the	DT
cord-295807-68sukdb1	677	9	pH	pH	NNP
cord-295807-68sukdb1	677	10	partition	partition	NN
cord-295807-68sukdb1	677	11	hypothesis	hypothesis	NN
cord-295807-68sukdb1	677	12	(	(	-LRB-
cord-295807-68sukdb1	677	13	first	first	RB
cord-295807-68sukdb1	677	14	described	describe	VBN
cord-295807-68sukdb1	677	15	by	by	IN
cord-295807-68sukdb1	677	16	Jacobs	Jacobs	NNP
cord-295807-68sukdb1	677	17	in	in	IN
cord-295807-68sukdb1	677	18	1940	1940	CD
cord-295807-68sukdb1	677	19	[	[	-LRB-
cord-295807-68sukdb1	677	20	448	448	CD
cord-295807-68sukdb1	677	21	]	]	-RRB-
cord-295807-68sukdb1	677	22	)	)	-RRB-
cord-295807-68sukdb1	677	23	to	to	TO
cord-295807-68sukdb1	677	24	describe	describe	VB
cord-295807-68sukdb1	677	25	the	the	DT
cord-295807-68sukdb1	677	26	influence	influence	NN
cord-295807-68sukdb1	677	27	of	of	IN
cord-295807-68sukdb1	677	28	pKa	pKa	NNP
cord-295807-68sukdb1	677	29	and	and	CC
cord-295807-68sukdb1	677	30	pH	pH	NNP
cord-295807-68sukdb1	677	31	upon	upon	IN
cord-295807-68sukdb1	677	32	the	the	DT
cord-295807-68sukdb1	677	33	gastric	gastric	JJ
cord-295807-68sukdb1	677	34	secretion	secretion	NN
cord-295807-68sukdb1	677	35	of	of	IN
cord-295807-68sukdb1	677	36	a	a	DT
cord-295807-68sukdb1	677	37	variety	variety	NN
cord-295807-68sukdb1	677	38	of	of	IN
cord-295807-68sukdb1	677	39	intravenously	intravenously	RB
cord-295807-68sukdb1	677	40	-	-	HYPH
cord-295807-68sukdb1	677	41	administered	administer	VBN
cord-295807-68sukdb1	677	42	weakly	weakly	RB
cord-295807-68sukdb1	677	43	acidic	acidic	JJ
cord-295807-68sukdb1	677	44	and	and	CC
cord-295807-68sukdb1	677	45	basic	basic	JJ
cord-295807-68sukdb1	677	46	drugs	drug	NNS
cord-295807-68sukdb1	677	47	[	[	-LRB-
cord-295807-68sukdb1	677	48	449	449	CD
cord-295807-68sukdb1	677	49	]	]	-RRB-
cord-295807-68sukdb1	677	50	.	.	.
cord-295807-68sukdb1	678	1	The	the	DT
cord-295807-68sukdb1	678	2	results	result	NNS
cord-295807-68sukdb1	678	3	of	of	IN
cord-295807-68sukdb1	678	4	their	-PRON-	PRP$
cord-295807-68sukdb1	678	5	experiments	experiment	NNS
cord-295807-68sukdb1	678	6	could	could	MD
cord-295807-68sukdb1	678	7	be	be	VB
cord-295807-68sukdb1	678	8	explained	explain	VBN
cord-295807-68sukdb1	678	9	with	with	IN
cord-295807-68sukdb1	678	10	their	-PRON-	PRP$
cord-295807-68sukdb1	678	11	theoretical	theoretical	JJ
cord-295807-68sukdb1	678	12	model	model	NN
cord-295807-68sukdb1	678	13	of	of	IN
cord-295807-68sukdb1	678	14	drug	drug	NN
cord-295807-68sukdb1	678	15	absorption	absorption	NN
cord-295807-68sukdb1	678	16	across	across	IN
cord-295807-68sukdb1	678	17	a	a	DT
cord-295807-68sukdb1	678	18	lipoid	lipoid	NNP
cord-295807-68sukdb1	678	19	barrier	barrier	NN
cord-295807-68sukdb1	678	20	(	(	-LRB-
cord-295807-68sukdb1	678	21	i.e.	i.e.	FW
cord-295807-68sukdb1	678	22	,	,	,
cord-295807-68sukdb1	678	23	the	the	DT
cord-295807-68sukdb1	678	24	gastric	gastric	JJ
cord-295807-68sukdb1	678	25	mucosa	mucosa	NN
cord-295807-68sukdb1	678	26	)	)	-RRB-
cord-295807-68sukdb1	678	27	that	that	WDT
cord-295807-68sukdb1	678	28	separates	separate	VBZ
cord-295807-68sukdb1	678	29	two	two	CD
cord-295807-68sukdb1	678	30	compartments	compartment	NNS
cord-295807-68sukdb1	678	31	(	(	-LRB-
cord-295807-68sukdb1	678	32	i.e.	i.e.	FW
cord-295807-68sukdb1	678	33	,	,	,
cord-295807-68sukdb1	678	34	the	the	DT
cord-295807-68sukdb1	678	35	stomach	stomach	NN
cord-295807-68sukdb1	678	36	lumen	lumen	NN
cord-295807-68sukdb1	678	37	and	and	CC
cord-295807-68sukdb1	678	38	the	the	DT
cord-295807-68sukdb1	678	39	blood	blood	NN
cord-295807-68sukdb1	678	40	)	)	-RRB-
cord-295807-68sukdb1	678	41	with	with	IN
cord-295807-68sukdb1	678	42	different	different	JJ
cord-295807-68sukdb1	678	43	pH	ph	NN
cord-295807-68sukdb1	678	44	and	and	CC
cord-295807-68sukdb1	678	45	permeable	permeable	JJ
cord-295807-68sukdb1	678	46	only	only	RB
cord-295807-68sukdb1	678	47	to	to	IN
cord-295807-68sukdb1	678	48	the	the	DT
cord-295807-68sukdb1	678	49	unionized	unionized	JJ
cord-295807-68sukdb1	678	50	form	form	NN
cord-295807-68sukdb1	678	51	,	,	,
cord-295807-68sukdb1	678	52	which	which	WDT
cord-295807-68sukdb1	678	53	was	be	VBD
cord-295807-68sukdb1	678	54	assumed	assume	VBN
cord-295807-68sukdb1	678	55	at	at	IN
cord-295807-68sukdb1	678	56	equilibrium	equilibrium	NN
cord-295807-68sukdb1	678	57	.	.	.
cord-295807-68sukdb1	679	1	They	-PRON-	PRP
cord-295807-68sukdb1	679	2	found	find	VBD
cord-295807-68sukdb1	679	3	that	that	IN
cord-295807-68sukdb1	679	4	the	the	DT
cord-295807-68sukdb1	679	5	extent	extent	NN
cord-295807-68sukdb1	679	6	to	to	TO
cord-295807-68sukdb1	679	7	which	which	WDT
cord-295807-68sukdb1	679	8	a	a	DT
cord-295807-68sukdb1	679	9	drug	drug	NN
cord-295807-68sukdb1	679	10	moves	move	VBZ
cord-295807-68sukdb1	679	11	between	between	IN
cord-295807-68sukdb1	679	12	compartments	compartment	NNS
cord-295807-68sukdb1	679	13	(	(	-LRB-
cord-295807-68sukdb1	679	14	the	the	DT
cord-295807-68sukdb1	679	15	GI	GI	NNP
cord-295807-68sukdb1	679	16	tract	tract	NN
cord-295807-68sukdb1	679	17	and	and	CC
cord-295807-68sukdb1	679	18	blood	blood	NN
cord-295807-68sukdb1	679	19	)	)	-RRB-
cord-295807-68sukdb1	679	20	depends	depend	VBZ
cord-295807-68sukdb1	679	21	on	on	IN
cord-295807-68sukdb1	679	22	the	the	DT
cord-295807-68sukdb1	679	23	value	value	NN
cord-295807-68sukdb1	679	24	of	of	IN
cord-295807-68sukdb1	679	25	the	the	DT
cord-295807-68sukdb1	679	26	drug	drug	NN
cord-295807-68sukdb1	679	27	pKa	pKa	NNPS
cord-295807-68sukdb1	679	28	and	and	CC
cord-295807-68sukdb1	679	29	the	the	DT
cord-295807-68sukdb1	679	30	environmental	environmental	JJ
cord-295807-68sukdb1	679	31	pH	pH	NNP
cord-295807-68sukdb1	679	32	values	value	NNS
cord-295807-68sukdb1	679	33	of	of	IN
cord-295807-68sukdb1	679	34	the	the	DT
cord-295807-68sukdb1	679	35	two	two	CD
cord-295807-68sukdb1	679	36	compartments	compartment	NNS
cord-295807-68sukdb1	679	37	such	such	JJ
cord-295807-68sukdb1	679	38	that	that	IN
cord-295807-68sukdb1	679	39	(	(	-LRB-
cord-295807-68sukdb1	679	40	using	use	VBG
cord-295807-68sukdb1	679	41	Equations	Equations	NNPS
cord-295807-68sukdb1	679	42	(	(	-LRB-
cord-295807-68sukdb1	679	43	3	3	CD
cord-295807-68sukdb1	679	44	)	)	-RRB-
cord-295807-68sukdb1	679	45	and	and	CC
cord-295807-68sukdb1	679	46	(	(	-LRB-
cord-295807-68sukdb1	679	47	5	5	LS
cord-295807-68sukdb1	679	48	)	)	-RRB-
cord-295807-68sukdb1	679	49	That	that	DT
cord-295807-68sukdb1	679	50	is	be	VBZ
cord-295807-68sukdb1	679	51	to	to	TO
cord-295807-68sukdb1	679	52	say	say	VB
cord-295807-68sukdb1	679	53	that	that	IN
cord-295807-68sukdb1	679	54	weakly	weakly	RB
cord-295807-68sukdb1	679	55	acidic	acidic	JJ
cord-295807-68sukdb1	679	56	drugs	drug	NNS
cord-295807-68sukdb1	679	57	such	such	JJ
cord-295807-68sukdb1	679	58	as	as	IN
cord-295807-68sukdb1	679	59	aspirin	aspirin	NN
cord-295807-68sukdb1	679	60	(	(	-LRB-
cord-295807-68sukdb1	679	61	pKa=3.5	pka=3.5	NN
cord-295807-68sukdb1	679	62	)	)	-RRB-
cord-295807-68sukdb1	679	63	can	can	MD
cord-295807-68sukdb1	679	64	be	be	VB
cord-295807-68sukdb1	679	65	effectively	effectively	RB
cord-295807-68sukdb1	679	66	absorbed	absorb	VBN
cord-295807-68sukdb1	679	67	from	from	IN
cord-295807-68sukdb1	679	68	the	the	DT
cord-295807-68sukdb1	679	69	stomach	stomach	NN
cord-295807-68sukdb1	679	70	.	.	.
cord-295807-68sukdb1	680	1	In	in	IN
cord-295807-68sukdb1	680	2	the	the	DT
cord-295807-68sukdb1	680	3	case	case	NN
cord-295807-68sukdb1	680	4	of	of	IN
cord-295807-68sukdb1	680	5	a	a	DT
cord-295807-68sukdb1	680	6	weakly	weakly	RB
cord-295807-68sukdb1	680	7	basic	basic	JJ
cord-295807-68sukdb1	680	8	drug	drug	NN
cord-295807-68sukdb1	680	9	.	.	.
cord-295807-68sukdb1	681	1	In	in	IN
cord-295807-68sukdb1	681	2	practice	practice	NN
cord-295807-68sukdb1	681	3	,	,	,
cord-295807-68sukdb1	681	4	the	the	DT
cord-295807-68sukdb1	681	5	model	model	NN
cord-295807-68sukdb1	681	6	has	have	VBZ
cord-295807-68sukdb1	681	7	several	several	JJ
cord-295807-68sukdb1	681	8	limitations	limitation	NNS
cord-295807-68sukdb1	681	9	because	because	IN
cord-295807-68sukdb1	681	10	the	the	DT
cord-295807-68sukdb1	681	11	pH	pH	NNP
cord-295807-68sukdb1	681	12	partition	partition	NN
cord-295807-68sukdb1	681	13	hypothesis	hypothesis	NN
cord-295807-68sukdb1	681	14	ignores	ignore	VBZ
cord-295807-68sukdb1	681	15	other	other	JJ
cord-295807-68sukdb1	681	16	substantial	substantial	JJ
cord-295807-68sukdb1	681	17	influences	influence	NNS
cord-295807-68sukdb1	681	18	upon	upon	IN
cord-295807-68sukdb1	681	19	drug	drug	NN
cord-295807-68sukdb1	681	20	absorption	absorption	NN
cord-295807-68sukdb1	681	21	.	.	.
cord-295807-68sukdb1	682	1	For	for	IN
cord-295807-68sukdb1	682	2	example	example	NN
cord-295807-68sukdb1	682	3	,	,	,
cord-295807-68sukdb1	682	4	the	the	DT
cord-295807-68sukdb1	682	5	assumption	assumption	NN
cord-295807-68sukdb1	682	6	of	of	IN
cord-295807-68sukdb1	682	7	equilibrium	equilibrium	NN
cord-295807-68sukdb1	682	8	is	be	VBZ
cord-295807-68sukdb1	682	9	unrealistic	unrealistic	JJ
cord-295807-68sukdb1	682	10	in	in	IN
cord-295807-68sukdb1	682	11	such	such	PDT
cord-295807-68sukdb1	682	12	a	a	DT
cord-295807-68sukdb1	682	13	dynamic	dynamic	JJ
cord-295807-68sukdb1	682	14	system	system	NN
cord-295807-68sukdb1	682	15	.	.	.
cord-295807-68sukdb1	683	1	Furthermore	furthermore	RB
cord-295807-68sukdb1	683	2	,	,	,
cord-295807-68sukdb1	683	3	even	even	RB
cord-295807-68sukdb1	683	4	weakly	weakly	RB
cord-295807-68sukdb1	683	5	acidic	acidic	JJ
cord-295807-68sukdb1	683	6	drugs	drug	NNS
cord-295807-68sukdb1	683	7	can	can	MD
cord-295807-68sukdb1	683	8	be	be	VB
cord-295807-68sukdb1	683	9	substantially	substantially	RB
cord-295807-68sukdb1	683	10	absorbed	absorb	VBN
cord-295807-68sukdb1	683	11	in	in	IN
cord-295807-68sukdb1	683	12	the	the	DT
cord-295807-68sukdb1	683	13	small	small	JJ
cord-295807-68sukdb1	683	14	intestine	intestine	NN
cord-295807-68sukdb1	683	15	because	because	IN
cord-295807-68sukdb1	683	16	of	of	IN
cord-295807-68sukdb1	683	17	the	the	DT
cord-295807-68sukdb1	683	18	large	large	JJ
cord-295807-68sukdb1	683	19	luminal	luminal	JJ
cord-295807-68sukdb1	683	20	surface	surface	NN
cord-295807-68sukdb1	683	21	area	area	NN
cord-295807-68sukdb1	683	22	that	that	IN
cord-295807-68sukdb1	683	23	it	-PRON-	PRP
cord-295807-68sukdb1	683	24	presents	present	VBZ
cord-295807-68sukdb1	683	25	[	[	-LRB-
cord-295807-68sukdb1	683	26	450	450	CD
cord-295807-68sukdb1	683	27	]	]	-RRB-
cord-295807-68sukdb1	683	28	.	.	.
cord-295807-68sukdb1	684	1	Finally	finally	RB
cord-295807-68sukdb1	684	2	,	,	,
cord-295807-68sukdb1	684	3	the	the	DT
cord-295807-68sukdb1	684	4	pH	ph	NN
cord-295807-68sukdb1	684	5	-	-	NN
cord-295807-68sukdb1	684	6	partition	partition	NN
cord-295807-68sukdb1	684	7	hypothesis	hypothesis	NN
cord-295807-68sukdb1	684	8	does	do	VBZ
cord-295807-68sukdb1	684	9	not	not	RB
cord-295807-68sukdb1	684	10	consider	consider	VB
cord-295807-68sukdb1	684	11	the	the	DT
cord-295807-68sukdb1	684	12	mechanism	mechanism	NN
cord-295807-68sukdb1	684	13	by	by	IN
cord-295807-68sukdb1	684	14	which	which	WDT
cord-295807-68sukdb1	684	15	drugs	drug	NNS
cord-295807-68sukdb1	684	16	can	can	MD
cord-295807-68sukdb1	684	17	move	move	VB
cord-295807-68sukdb1	684	18	across	across	IN
cord-295807-68sukdb1	684	19	epithelial	epithelial	JJ
cord-295807-68sukdb1	684	20	layers	layer	NNS
cord-295807-68sukdb1	684	21	.	.	.
cord-295807-68sukdb1	685	1	Today	today	NN
cord-295807-68sukdb1	685	2	we	-PRON-	PRP
cord-295807-68sukdb1	685	3	know	know	VBP
cord-295807-68sukdb1	685	4	that	that	IN
cord-295807-68sukdb1	685	5	both	both	CC
cord-295807-68sukdb1	685	6	the	the	DT
cord-295807-68sukdb1	685	7	transcellular	transcellular	NNP
cord-295807-68sukdb1	685	8	and	and	CC
cord-295807-68sukdb1	685	9	paracellular	paracellular	JJ
cord-295807-68sukdb1	685	10	pathways	pathway	NNS
cord-295807-68sukdb1	685	11	play	play	VBP
cord-295807-68sukdb1	685	12	important	important	JJ
cord-295807-68sukdb1	685	13	roles	role	NNS
cord-295807-68sukdb1	685	14	in	in	IN
cord-295807-68sukdb1	685	15	the	the	DT
cord-295807-68sukdb1	685	16	absorption	absorption	NN
cord-295807-68sukdb1	685	17	and	and	CC
cord-295807-68sukdb1	685	18	elimination	elimination	NN
cord-295807-68sukdb1	685	19	of	of	IN
cord-295807-68sukdb1	685	20	both	both	CC
cord-295807-68sukdb1	685	21	charged	charge	VBN
cord-295807-68sukdb1	685	22	and	and	CC
cord-295807-68sukdb1	685	23	uncharged	uncharged	JJ
cord-295807-68sukdb1	685	24	drug	drug	NN
cord-295807-68sukdb1	685	25	forms	form	NNS
cord-295807-68sukdb1	685	26	[	[	-LRB-
cord-295807-68sukdb1	685	27	451	451	CD
cord-295807-68sukdb1	685	28	]	]	-RRB-
cord-295807-68sukdb1	685	29	.	.	.
cord-295807-68sukdb1	686	1	Low	low	JJ
cord-295807-68sukdb1	686	2	-	-	HYPH
cord-295807-68sukdb1	686	3	specificity	specificity	NN
cord-295807-68sukdb1	686	4	membrane	membrane	NN
cord-295807-68sukdb1	686	5	transporter	transporter	NN
cord-295807-68sukdb1	686	6	proteins	protein	NNS
cord-295807-68sukdb1	686	7	that	that	WDT
cord-295807-68sukdb1	686	8	contribute	contribute	VBP
cord-295807-68sukdb1	686	9	to	to	IN
cord-295807-68sukdb1	686	10	transcellular	transcellular	NNP
cord-295807-68sukdb1	686	11	drug	drug	NN
cord-295807-68sukdb1	686	12	transport	transport	NN
cord-295807-68sukdb1	686	13	around	around	IN
cord-295807-68sukdb1	686	14	the	the	DT
cord-295807-68sukdb1	686	15	body	body	NN
cord-295807-68sukdb1	686	16	include	include	VBP
cord-295807-68sukdb1	686	17	organic	organic	JJ
cord-295807-68sukdb1	686	18	anion	anion	NN
cord-295807-68sukdb1	686	19	transporters	transporter	NNS
cord-295807-68sukdb1	686	20	(	(	-LRB-
cord-295807-68sukdb1	686	21	OATs	OATs	NNP
cord-295807-68sukdb1	686	22	)	)	-RRB-
cord-295807-68sukdb1	686	23	,	,	,
cord-295807-68sukdb1	686	24	organic	organic	JJ
cord-295807-68sukdb1	686	25	cation	cation	NN
cord-295807-68sukdb1	686	26	transporters	transporter	NNS
cord-295807-68sukdb1	686	27	(	(	-LRB-
cord-295807-68sukdb1	686	28	OCTs	OCTs	NNPS
cord-295807-68sukdb1	686	29	)	)	-RRB-
cord-295807-68sukdb1	686	30	,	,	,
cord-295807-68sukdb1	686	31	some	some	DT
cord-295807-68sukdb1	686	32	MCTs	mct	NNS
cord-295807-68sukdb1	686	33	,	,	,
cord-295807-68sukdb1	686	34	and	and	CC
cord-295807-68sukdb1	686	35	members	member	NNS
cord-295807-68sukdb1	686	36	of	of	IN
cord-295807-68sukdb1	686	37	the	the	DT
cord-295807-68sukdb1	686	38	ABC	ABC	NNP
cord-295807-68sukdb1	686	39	transporter	transporter	NN
cord-295807-68sukdb1	686	40	superfamily	superfamily	NN
cord-295807-68sukdb1	686	41	,	,	,
cord-295807-68sukdb1	686	42	such	such	JJ
cord-295807-68sukdb1	686	43	as	as	IN
cord-295807-68sukdb1	686	44	the	the	DT
cord-295807-68sukdb1	686	45	P	p	NN
cord-295807-68sukdb1	686	46	-	-	HYPH
cord-295807-68sukdb1	686	47	glycoprotein	glycoprotein	NN
cord-295807-68sukdb1	686	48	transporters	transporter	NNS
cord-295807-68sukdb1	686	49	(	(	-LRB-
cord-295807-68sukdb1	686	50	P	p	NN
cord-295807-68sukdb1	686	51	-	-	HYPH
cord-295807-68sukdb1	686	52	gp	gp	NN
cord-295807-68sukdb1	686	53	)	)	-RRB-
cord-295807-68sukdb1	686	54	[	[	-LRB-
cord-295807-68sukdb1	686	55	452	452	CD
cord-295807-68sukdb1	686	56	]	]	-RRB-
cord-295807-68sukdb1	686	57	[	[	-LRB-
cord-295807-68sukdb1	686	58	453	453	CD
cord-295807-68sukdb1	686	59	]	]	-RRB-
cord-295807-68sukdb1	686	60	[	[	-LRB-
cord-295807-68sukdb1	686	61	454	454	CD
cord-295807-68sukdb1	686	62	]	]	-RRB-
cord-295807-68sukdb1	686	63	[	[	-LRB-
cord-295807-68sukdb1	686	64	455	455	CD
cord-295807-68sukdb1	686	65	]	]	-RRB-
cord-295807-68sukdb1	686	66	[	[	-LRB-
cord-295807-68sukdb1	686	67	456	456	CD
cord-295807-68sukdb1	686	68	]	]	-RRB-
cord-295807-68sukdb1	686	69	.	.	.
cord-295807-68sukdb1	687	1	In	in	IN
cord-295807-68sukdb1	687	2	some	some	DT
cord-295807-68sukdb1	687	3	cases	case	NNS
cord-295807-68sukdb1	687	4	,	,	,
cord-295807-68sukdb1	687	5	the	the	DT
cord-295807-68sukdb1	687	6	transporters	transporter	NNS
cord-295807-68sukdb1	687	7	themselves	-PRON-	PRP
cord-295807-68sukdb1	687	8	may	may	MD
cord-295807-68sukdb1	687	9	be	be	VB
cord-295807-68sukdb1	687	10	pH	ph	NN
cord-295807-68sukdb1	687	11	-	-	HYPH
cord-295807-68sukdb1	687	12	sensitive	sensitive	JJ
cord-295807-68sukdb1	687	13	or	or	CC
cord-295807-68sukdb1	687	14	coupled	coupled	JJ
cord-295807-68sukdb1	687	15	to	to	IN
cord-295807-68sukdb1	687	16	the	the	DT
cord-295807-68sukdb1	687	17	transport	transport	NN
cord-295807-68sukdb1	687	18	of	of	IN
cord-295807-68sukdb1	687	19	acids	acid	NNS
cord-295807-68sukdb1	687	20	and	and	CC
cord-295807-68sukdb1	687	21	bases	basis	NNS
cord-295807-68sukdb1	687	22	.	.	.
cord-295807-68sukdb1	688	1	The	the	DT
cord-295807-68sukdb1	688	2	importance	importance	NN
cord-295807-68sukdb1	688	3	of	of	IN
cord-295807-68sukdb1	688	4	such	such	JJ
cord-295807-68sukdb1	688	5	considerations	consideration	NNS
cord-295807-68sukdb1	688	6	is	be	VBZ
cord-295807-68sukdb1	688	7	exemplified	exemplify	VBN
cord-295807-68sukdb1	688	8	by	by	IN
cord-295807-68sukdb1	688	9	lowered	lower	VBN
cord-295807-68sukdb1	688	10	absorption	absorption	NN
cord-295807-68sukdb1	688	11	of	of	IN
cord-295807-68sukdb1	688	12	weakly	weakly	RB
cord-295807-68sukdb1	688	13	basic	basic	JJ
cord-295807-68sukdb1	688	14	drugs	drug	NNS
cord-295807-68sukdb1	688	15	in	in	IN
cord-295807-68sukdb1	688	16	individuals	individual	NNS
cord-295807-68sukdb1	688	17	with	with	IN
cord-295807-68sukdb1	688	18	an	an	DT
cord-295807-68sukdb1	688	19	unusually	unusually	RB
cord-295807-68sukdb1	688	20	high	high	JJ
cord-295807-68sukdb1	688	21	stomach	stomach	NN
cord-295807-68sukdb1	688	22	pH	ph	NN
cord-295807-68sukdb1	688	23	such	such	JJ
cord-295807-68sukdb1	688	24	as	as	IN
cord-295807-68sukdb1	688	25	those	those	DT
cord-295807-68sukdb1	688	26	taking	take	VBG
cord-295807-68sukdb1	688	27	PPIs	ppi	NNS
cord-295807-68sukdb1	688	28	or	or	CC
cord-295807-68sukdb1	688	29	individuals	individual	NNS
cord-295807-68sukdb1	688	30	with	with	IN
cord-295807-68sukdb1	688	31	achlorhydria	achlorhydria	NNP
cord-295807-68sukdb1	688	32	[	[	-LRB-
cord-295807-68sukdb1	688	33	457	457	CD
cord-295807-68sukdb1	688	34	]	]	-RRB-
cord-295807-68sukdb1	688	35	.	.	.
cord-295807-68sukdb1	689	1	For	for	IN
cord-295807-68sukdb1	689	2	example	example	NN
cord-295807-68sukdb1	689	3	,	,	,
cord-295807-68sukdb1	689	4	the	the	DT
cord-295807-68sukdb1	689	5	dissolution	dissolution	NN
cord-295807-68sukdb1	689	6	and	and	CC
cord-295807-68sukdb1	689	7	absorption	absorption	NN
cord-295807-68sukdb1	689	8	rate	rate	NN
cord-295807-68sukdb1	689	9	of	of	IN
cord-295807-68sukdb1	689	10	the	the	DT
cord-295807-68sukdb1	689	11	weakly	weakly	RB
cord-295807-68sukdb1	689	12	basic	basic	JJ
cord-295807-68sukdb1	689	13	antifungal	antifungal	JJ
cord-295807-68sukdb1	689	14	agent	agent	NN
cord-295807-68sukdb1	689	15	ketoconazole	ketoconazole	NNP
cord-295807-68sukdb1	689	16	,	,	,
cord-295807-68sukdb1	689	17	which	which	WDT
cord-295807-68sukdb1	689	18	is	be	VBZ
cord-295807-68sukdb1	689	19	soluble	soluble	JJ
cord-295807-68sukdb1	689	20	only	only	RB
cord-295807-68sukdb1	689	21	at	at	IN
cord-295807-68sukdb1	689	22	pH	pH	NNP
cord-295807-68sukdb1	689	23	lower	low	JJR
cord-295807-68sukdb1	689	24	than	than	IN
cord-295807-68sukdb1	689	25	3	3	CD
cord-295807-68sukdb1	689	26	,	,	,
cord-295807-68sukdb1	689	27	can	can	MD
cord-295807-68sukdb1	689	28	be	be	VB
cord-295807-68sukdb1	689	29	enhanced	enhance	VBN
cord-295807-68sukdb1	689	30	by	by	IN
cord-295807-68sukdb1	689	31	coadministration	coadministration	NN
cord-295807-68sukdb1	689	32	of	of	IN
cord-295807-68sukdb1	689	33	an	an	DT
cord-295807-68sukdb1	689	34	acidic	acidic	JJ
cord-295807-68sukdb1	689	35	,	,	,
cord-295807-68sukdb1	689	36	carbonated	carbonated	JJ
cord-295807-68sukdb1	689	37	beverage	beverage	NN
cord-295807-68sukdb1	689	38	[	[	-LRB-
cord-295807-68sukdb1	689	39	457	457	CD
cord-295807-68sukdb1	689	40	]	]	-RRB-
cord-295807-68sukdb1	689	41	.	.	.
cord-295807-68sukdb1	690	1	A	a	DT
cord-295807-68sukdb1	690	2	related	related	JJ
cord-295807-68sukdb1	690	3	example	example	NN
cord-295807-68sukdb1	690	4	,	,	,
cord-295807-68sukdb1	690	5	albeit	albeit	IN
cord-295807-68sukdb1	690	6	related	relate	VBN
cord-295807-68sukdb1	690	7	to	to	IN
cord-295807-68sukdb1	690	8	absorption	absorption	NN
cord-295807-68sukdb1	690	9	of	of	IN
cord-295807-68sukdb1	690	10	drugs	drug	NNS
cord-295807-68sukdb1	690	11	by	by	IN
cord-295807-68sukdb1	690	12	bacteria	bacteria	NNS
cord-295807-68sukdb1	690	13	,	,	,
cord-295807-68sukdb1	690	14	is	be	VBZ
cord-295807-68sukdb1	690	15	that	that	IN
cord-295807-68sukdb1	690	16	the	the	DT
cord-295807-68sukdb1	690	17	adjuvant	adjuvant	JJ
cord-295807-68sukdb1	690	18	use	use	NN
cord-295807-68sukdb1	690	19	of	of	IN
cord-295807-68sukdb1	690	20	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	690	21	enhances	enhance	VBZ
cord-295807-68sukdb1	690	22	the	the	DT
cord-295807-68sukdb1	690	23	in	in	FW
cord-295807-68sukdb1	690	24	vitro	vitro	FW
cord-295807-68sukdb1	690	25	potency	potency	NN
cord-295807-68sukdb1	690	26	of	of	IN
cord-295807-68sukdb1	690	27	antibiotics	antibiotic	NNS
cord-295807-68sukdb1	690	28	by	by	IN
cord-295807-68sukdb1	690	29	interfering	interfere	VBG
cord-295807-68sukdb1	690	30	with	with	IN
cord-295807-68sukdb1	690	31	the	the	DT
cord-295807-68sukdb1	690	32	proton	proton	NN
cord-295807-68sukdb1	690	33	motive	motive	NN
cord-295807-68sukdb1	690	34	force	force	NN
cord-295807-68sukdb1	690	35	that	that	WDT
cord-295807-68sukdb1	690	36	drives	drive	VBZ
cord-295807-68sukdb1	690	37	antibiotic	antibiotic	JJ
cord-295807-68sukdb1	690	38	efflux	efflux	NN
cord-295807-68sukdb1	690	39	from	from	IN
cord-295807-68sukdb1	690	40	bacteria	bacteria	NNS
cord-295807-68sukdb1	690	41	[	[	-LRB-
cord-295807-68sukdb1	690	42	458	458	CD
cord-295807-68sukdb1	690	43	]	]	-RRB-
cord-295807-68sukdb1	690	44	.	.	.
cord-295807-68sukdb1	691	1	As	as	IN
cord-295807-68sukdb1	691	2	we	-PRON-	PRP
cord-295807-68sukdb1	691	3	will	will	MD
cord-295807-68sukdb1	691	4	see	see	VB
cord-295807-68sukdb1	691	5	in	in	IN
cord-295807-68sukdb1	691	6	section	section	NN
cord-295807-68sukdb1	691	7	6.5	6.5	CD
cord-295807-68sukdb1	691	8	,	,	,
cord-295807-68sukdb1	691	9	considerations	consideration	NNS
cord-295807-68sukdb1	691	10	of	of	IN
cord-295807-68sukdb1	691	11	drug	drug	NN
cord-295807-68sukdb1	691	12	solubility	solubility	NN
cord-295807-68sukdb1	691	13	and	and	CC
cord-295807-68sukdb1	691	14	transepithelial	transepithelial	JJ
cord-295807-68sukdb1	691	15	movement	movement	NN
cord-295807-68sukdb1	691	16	also	also	RB
cord-295807-68sukdb1	691	17	influence	influence	VBP
cord-295807-68sukdb1	691	18	drug	drug	NN
cord-295807-68sukdb1	691	19	elimination	elimination	NN
cord-295807-68sukdb1	691	20	in	in	IN
cord-295807-68sukdb1	691	21	urine	urine	NN
cord-295807-68sukdb1	691	22	by	by	IN
cord-295807-68sukdb1	691	23	the	the	DT
cord-295807-68sukdb1	691	24	kidneys	kidney	NNS
cord-295807-68sukdb1	691	25	.	.	.
cord-295807-68sukdb1	692	1	When	when	WRB
cord-295807-68sukdb1	692	2	developing	develop	VBG
cord-295807-68sukdb1	692	3	drugs	drug	NNS
cord-295807-68sukdb1	692	4	for	for	IN
cord-295807-68sukdb1	692	5	oral	oral	JJ
cord-295807-68sukdb1	692	6	delivery	delivery	NN
cord-295807-68sukdb1	692	7	it	-PRON-	PRP
cord-295807-68sukdb1	692	8	is	be	VBZ
cord-295807-68sukdb1	692	9	important	important	JJ
cord-295807-68sukdb1	692	10	to	to	TO
cord-295807-68sukdb1	692	11	account	account	VB
cord-295807-68sukdb1	692	12	for	for	IN
cord-295807-68sukdb1	692	13	the	the	DT
cord-295807-68sukdb1	692	14	adverse	adverse	JJ
cord-295807-68sukdb1	692	15	acidic	acidic	JJ
cord-295807-68sukdb1	692	16	environment	environment	NN
cord-295807-68sukdb1	692	17	of	of	IN
cord-295807-68sukdb1	692	18	the	the	DT
cord-295807-68sukdb1	692	19	stomach	stomach	NN
cord-295807-68sukdb1	692	20	,	,	,
cord-295807-68sukdb1	692	21	which	which	WDT
cord-295807-68sukdb1	692	22	can	can	MD
cord-295807-68sukdb1	692	23	cause	cause	VB
cord-295807-68sukdb1	692	24	instability	instability	NN
cord-295807-68sukdb1	692	25	and	and	CC
cord-295807-68sukdb1	692	26	rapid	rapid	JJ
cord-295807-68sukdb1	692	27	degradation	degradation	NN
cord-295807-68sukdb1	692	28	of	of	IN
cord-295807-68sukdb1	692	29	drugs	drug	NNS
cord-295807-68sukdb1	692	30	before	before	IN
cord-295807-68sukdb1	692	31	they	-PRON-	PRP
cord-295807-68sukdb1	692	32	reach	reach	VBP
cord-295807-68sukdb1	692	33	the	the	DT
cord-295807-68sukdb1	692	34	small	small	JJ
cord-295807-68sukdb1	692	35	intestine	intestine	NN
cord-295807-68sukdb1	692	36	for	for	IN
cord-295807-68sukdb1	692	37	absorption	absorption	NN
cord-295807-68sukdb1	692	38	.	.	.
cord-295807-68sukdb1	693	1	This	this	DT
cord-295807-68sukdb1	693	2	could	could	MD
cord-295807-68sukdb1	693	3	happen	happen	VB
cord-295807-68sukdb1	693	4	because	because	IN
cord-295807-68sukdb1	693	5	the	the	DT
cord-295807-68sukdb1	693	6	polymers	polymer	NNS
cord-295807-68sukdb1	693	7	used	use	VBN
cord-295807-68sukdb1	693	8	for	for	IN
cord-295807-68sukdb1	693	9	the	the	DT
cord-295807-68sukdb1	693	10	tablet	tablet	NN
cord-295807-68sukdb1	693	11	coating	coating	NN
cord-295807-68sukdb1	693	12	may	may	MD
cord-295807-68sukdb1	693	13	be	be	VB
cord-295807-68sukdb1	693	14	susceptible	susceptible	JJ
cord-295807-68sukdb1	693	15	to	to	IN
cord-295807-68sukdb1	693	16	pH.	ph.	NN
cord-295807-68sukdb1	694	1	For	for	IN
cord-295807-68sukdb1	694	2	this	this	DT
cord-295807-68sukdb1	694	3	reason	reason	NN
cord-295807-68sukdb1	694	4	,	,	,
cord-295807-68sukdb1	694	5	carriers	carrier	NNS
cord-295807-68sukdb1	694	6	for	for	IN
cord-295807-68sukdb1	694	7	oral	oral	JJ
cord-295807-68sukdb1	694	8	drug	drug	NN
cord-295807-68sukdb1	694	9	delivery	delivery	NN
cord-295807-68sukdb1	694	10	are	be	VBP
cord-295807-68sukdb1	694	11	tested	test	VBN
cord-295807-68sukdb1	694	12	for	for	IN
cord-295807-68sukdb1	694	13	pH	ph	NN
cord-295807-68sukdb1	694	14	-	-	NN
cord-295807-68sukdb1	694	15	sensitivity	sensitivity	NN
cord-295807-68sukdb1	694	16	and	and	CC
cord-295807-68sukdb1	694	17	endurance	endurance	NN
cord-295807-68sukdb1	694	18	in	in	IN
cord-295807-68sukdb1	694	19	acidic	acidic	JJ
cord-295807-68sukdb1	694	20	environment	environment	NN
cord-295807-68sukdb1	694	21	.	.	.
cord-295807-68sukdb1	695	1	Acid	acid	NN
cord-295807-68sukdb1	695	2	-	-	HYPH
cord-295807-68sukdb1	695	3	resistant	resistant	JJ
cord-295807-68sukdb1	695	4	polymers	polymer	NNS
cord-295807-68sukdb1	695	5	that	that	WDT
cord-295807-68sukdb1	695	6	only	only	RB
cord-295807-68sukdb1	695	7	dissolve	dissolve	VBP
cord-295807-68sukdb1	695	8	above	above	IN
cord-295807-68sukdb1	695	9	certain	certain	JJ
cord-295807-68sukdb1	695	10	pH	ph	NN
cord-295807-68sukdb1	695	11	values	value	NNS
cord-295807-68sukdb1	695	12	are	be	VBP
cord-295807-68sukdb1	695	13	sometimes	sometimes	RB
cord-295807-68sukdb1	695	14	used	use	VBN
cord-295807-68sukdb1	695	15	as	as	IN
cord-295807-68sukdb1	695	16	enteric	enteric	JJ
cord-295807-68sukdb1	695	17	or	or	CC
cord-295807-68sukdb1	695	18	gastro	gastro	JJ
cord-295807-68sukdb1	695	19	-	-	JJ
cord-295807-68sukdb1	695	20	resistant	resistant	JJ
cord-295807-68sukdb1	695	21	coatings	coating	NNS
cord-295807-68sukdb1	695	22	[	[	-LRB-
cord-295807-68sukdb1	695	23	459	459	CD
cord-295807-68sukdb1	695	24	]	]	-RRB-
cord-295807-68sukdb1	695	25	[	[	-LRB-
cord-295807-68sukdb1	695	26	460	460	CD
cord-295807-68sukdb1	695	27	]	]	-RRB-
cord-295807-68sukdb1	695	28	[	[	-LRB-
cord-295807-68sukdb1	695	29	461	461	CD
cord-295807-68sukdb1	695	30	]	]	-RRB-
cord-295807-68sukdb1	695	31	[	[	-LRB-
cord-295807-68sukdb1	695	32	462	462	CD
cord-295807-68sukdb1	695	33	]	]	-RRB-
cord-295807-68sukdb1	695	34	.	.	.
cord-295807-68sukdb1	696	1	This	this	DT
cord-295807-68sukdb1	696	2	is	be	VBZ
cord-295807-68sukdb1	696	3	the	the	DT
cord-295807-68sukdb1	696	4	case	case	NN
cord-295807-68sukdb1	696	5	,	,	,
cord-295807-68sukdb1	696	6	for	for	IN
cord-295807-68sukdb1	696	7	example	example	NN
cord-295807-68sukdb1	696	8	,	,	,
cord-295807-68sukdb1	696	9	for	for	IN
cord-295807-68sukdb1	696	10	oral	oral	JJ
cord-295807-68sukdb1	696	11	delivery	delivery	NN
cord-295807-68sukdb1	696	12	of	of	IN
cord-295807-68sukdb1	696	13	insulin	insulin	NN
cord-295807-68sukdb1	696	14	[	[	-LRB-
cord-295807-68sukdb1	696	15	463	463	CD
cord-295807-68sukdb1	696	16	,	,	,
cord-295807-68sukdb1	696	17	464	464	CD
cord-295807-68sukdb1	696	18	]	]	-RRB-
cord-295807-68sukdb1	696	19	.	.	.
cord-295807-68sukdb1	697	1	The	the	DT
cord-295807-68sukdb1	697	2	pH	pH	NNP
cord-295807-68sukdb1	697	3	partition	partition	NN
cord-295807-68sukdb1	697	4	hypothesis	hypothesis	NN
cord-295807-68sukdb1	697	5	provides	provide	VBZ
cord-295807-68sukdb1	697	6	the	the	DT
cord-295807-68sukdb1	697	7	theoretical	theoretical	JJ
cord-295807-68sukdb1	697	8	framework	framework	NN
cord-295807-68sukdb1	697	9	for	for	IN
cord-295807-68sukdb1	697	10	understanding	understand	VBG
cord-295807-68sukdb1	697	11	how	how	WRB
cord-295807-68sukdb1	697	12	urinary	urinary	JJ
cord-295807-68sukdb1	697	13	pH	pH	NNP
cord-295807-68sukdb1	697	14	influences	influence	NNS
cord-295807-68sukdb1	697	15	renal	renal	JJ
cord-295807-68sukdb1	697	16	drug	drug	NN
cord-295807-68sukdb1	697	17	excretion	excretion	NN
cord-295807-68sukdb1	697	18	;	;	:
cord-295807-68sukdb1	697	19	acidification	acidification	NN
cord-295807-68sukdb1	697	20	of	of	IN
cord-295807-68sukdb1	697	21	urine	urine	NN
cord-295807-68sukdb1	697	22	favors	favor	VBZ
cord-295807-68sukdb1	697	23	elimination	elimination	NN
cord-295807-68sukdb1	697	24	of	of	IN
cord-295807-68sukdb1	697	25	weakly	weakly	RB
cord-295807-68sukdb1	697	26	basic	basic	JJ
cord-295807-68sukdb1	697	27	drugs	drug	NNS
cord-295807-68sukdb1	697	28	(	(	-LRB-
cord-295807-68sukdb1	697	29	because	because	IN
cord-295807-68sukdb1	697	30	their	-PRON-	PRP$
cord-295807-68sukdb1	697	31	absorption	absorption	NN
cord-295807-68sukdb1	697	32	is	be	VBZ
cord-295807-68sukdb1	697	33	reduced	reduce	VBN
cord-295807-68sukdb1	697	34	)	)	-RRB-
cord-295807-68sukdb1	697	35	whereas	whereas	IN
cord-295807-68sukdb1	697	36	alkalinization	alkalinization	NN
cord-295807-68sukdb1	697	37	of	of	IN
cord-295807-68sukdb1	697	38	urine	urine	NN
cord-295807-68sukdb1	697	39	favors	favor	VBZ
cord-295807-68sukdb1	697	40	elimination	elimination	NN
cord-295807-68sukdb1	697	41	of	of	IN
cord-295807-68sukdb1	697	42	weakly	weakly	RB
cord-295807-68sukdb1	697	43	acidic	acidic	JJ
cord-295807-68sukdb1	697	44	drugs	drug	NNS
cord-295807-68sukdb1	697	45	.	.	.
cord-295807-68sukdb1	698	1	For	for	IN
cord-295807-68sukdb1	698	2	example	example	NN
cord-295807-68sukdb1	698	3	,	,	,
cord-295807-68sukdb1	698	4	urine	urine	NN
cord-295807-68sukdb1	698	5	acidification	acidification	NN
cord-295807-68sukdb1	698	6	via	via	IN
cord-295807-68sukdb1	698	7	administration	administration	NN
cord-295807-68sukdb1	698	8	of	of	IN
cord-295807-68sukdb1	698	9	ammonium	ammonium	NN
cord-295807-68sukdb1	698	10	chloride	chloride	NN
cord-295807-68sukdb1	698	11	increases	increase	NNS
cord-295807-68sukdb1	698	12	elimination	elimination	NN
cord-295807-68sukdb1	698	13	of	of	IN
cord-295807-68sukdb1	698	14	the	the	DT
cord-295807-68sukdb1	698	15	weakly	weakly	RB
cord-295807-68sukdb1	698	16	basic	basic	JJ
cord-295807-68sukdb1	698	17	drug	drug	NN
cord-295807-68sukdb1	698	18	amphetamine	amphetamine	NN
cord-295807-68sukdb1	698	19	[	[	-LRB-
cord-295807-68sukdb1	698	20	465	465	CD
cord-295807-68sukdb1	698	21	]	]	-RRB-
cord-295807-68sukdb1	698	22	,	,	,
cord-295807-68sukdb1	698	23	whereas	whereas	IN
cord-295807-68sukdb1	698	24	urine	urine	NN
cord-295807-68sukdb1	698	25	alkalinization	alkalinization	NN
cord-295807-68sukdb1	698	26	via	via	IN
cord-295807-68sukdb1	698	27	intravenous	intravenous	JJ
cord-295807-68sukdb1	698	28	administration	administration	NN
cord-295807-68sukdb1	698	29	of	of	IN
cord-295807-68sukdb1	698	30	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	698	31	enhances	enhance	VBZ
cord-295807-68sukdb1	698	32	elimination	elimination	NN
cord-295807-68sukdb1	698	33	of	of	IN
cord-295807-68sukdb1	698	34	acidic	acidic	JJ
cord-295807-68sukdb1	698	35	drugs	drug	NNS
cord-295807-68sukdb1	698	36	like	like	IN
cord-295807-68sukdb1	698	37	salicylic	salicylic	NN
cord-295807-68sukdb1	698	38	acid	acid	NN
cord-295807-68sukdb1	698	39	(	(	-LRB-
cord-295807-68sukdb1	698	40	i.e.	i.e.	FW
cord-295807-68sukdb1	698	41	,	,	,
cord-295807-68sukdb1	698	42	aspirin	aspirin	NN
cord-295807-68sukdb1	698	43	)	)	-RRB-
cord-295807-68sukdb1	698	44	and	and	CC
cord-295807-68sukdb1	698	45	can	can	MD
cord-295807-68sukdb1	698	46	be	be	VB
cord-295807-68sukdb1	698	47	helpful	helpful	JJ
cord-295807-68sukdb1	698	48	in	in	IN
cord-295807-68sukdb1	698	49	the	the	DT
cord-295807-68sukdb1	698	50	management	management	NN
cord-295807-68sukdb1	698	51	of	of	IN
cord-295807-68sukdb1	698	52	drug	drug	NN
cord-295807-68sukdb1	698	53	poisoning	poisoning	NN
cord-295807-68sukdb1	698	54	like	like	IN
cord-295807-68sukdb1	698	55	aspirin	aspirin	NN
cord-295807-68sukdb1	698	56	intoxication	intoxication	NN
cord-295807-68sukdb1	698	57	[	[	-LRB-
cord-295807-68sukdb1	698	58	465	465	CD
cord-295807-68sukdb1	698	59	]	]	-RRB-
cord-295807-68sukdb1	698	60	[	[	-LRB-
cord-295807-68sukdb1	698	61	466	466	CD
cord-295807-68sukdb1	698	62	]	]	-RRB-
cord-295807-68sukdb1	698	63	[	[	-LRB-
cord-295807-68sukdb1	698	64	467	467	CD
cord-295807-68sukdb1	698	65	]	]	-RRB-
cord-295807-68sukdb1	698	66	.	.	.
cord-295807-68sukdb1	699	1	As	as	IN
cord-295807-68sukdb1	699	2	we	-PRON-	PRP
cord-295807-68sukdb1	699	3	considered	consider	VBD
cord-295807-68sukdb1	699	4	earlier	early	RBR
cord-295807-68sukdb1	699	5	,	,	,
cord-295807-68sukdb1	699	6	partitioning	partitioning	NN
cord-295807-68sukdb1	699	7	is	be	VBZ
cord-295807-68sukdb1	699	8	just	just	RB
cord-295807-68sukdb1	699	9	one	one	CD
cord-295807-68sukdb1	699	10	aspect	aspect	NN
cord-295807-68sukdb1	699	11	of	of	IN
cord-295807-68sukdb1	699	12	drug	drug	NN
cord-295807-68sukdb1	699	13	distribution	distribution	NN
cord-295807-68sukdb1	699	14	.	.	.
cord-295807-68sukdb1	700	1	Many	many	JJ
cord-295807-68sukdb1	700	2	OATs	oat	NNS
cord-295807-68sukdb1	700	3	and	and	CC
cord-295807-68sukdb1	700	4	OCTs	OCTs	NNPS
cord-295807-68sukdb1	700	5	[	[	-LRB-
cord-295807-68sukdb1	700	6	468	468	CD
cord-295807-68sukdb1	700	7	]	]	-RRB-
cord-295807-68sukdb1	700	8	are	be	VBP
cord-295807-68sukdb1	700	9	expressed	express	VBN
cord-295807-68sukdb1	700	10	in	in	IN
cord-295807-68sukdb1	700	11	nephron	nephron	NN
cord-295807-68sukdb1	700	12	epithelia	epithelium	NNS
cord-295807-68sukdb1	700	13	where	where	WRB
cord-295807-68sukdb1	700	14	their	-PRON-	PRP$
cord-295807-68sukdb1	700	15	action	action	NN
cord-295807-68sukdb1	700	16	is	be	VBZ
cord-295807-68sukdb1	700	17	vital	vital	JJ
cord-295807-68sukdb1	700	18	for	for	IN
cord-295807-68sukdb1	700	19	delivering	deliver	VBG
cord-295807-68sukdb1	700	20	drugs	drug	NNS
cord-295807-68sukdb1	700	21	from	from	IN
cord-295807-68sukdb1	700	22	the	the	DT
cord-295807-68sukdb1	700	23	peritubular	peritubular	JJ
cord-295807-68sukdb1	700	24	capillaries	capillarie	VBZ
cord-295807-68sukdb1	700	25	into	into	IN
cord-295807-68sukdb1	700	26	the	the	DT
cord-295807-68sukdb1	700	27	nephron	nephron	NN
cord-295807-68sukdb1	700	28	lumen	lumen	NN
cord-295807-68sukdb1	700	29	for	for	IN
cord-295807-68sukdb1	700	30	excretion	excretion	NN
cord-295807-68sukdb1	700	31	in	in	IN
cord-295807-68sukdb1	700	32	urine	urine	NN
cord-295807-68sukdb1	700	33	and	and	CC
cord-295807-68sukdb1	700	34	for	for	IN
cord-295807-68sukdb1	700	35	delivering	deliver	VBG
cord-295807-68sukdb1	700	36	diuretics	diuretic	NNS
cord-295807-68sukdb1	700	37	(	(	-LRB-
cord-295807-68sukdb1	700	38	e.g.	e.g.	RB
cord-295807-68sukdb1	700	39	,	,	,
cord-295807-68sukdb1	700	40	furosemide	furosemide	NN
cord-295807-68sukdb1	700	41	)	)	-RRB-
cord-295807-68sukdb1	700	42	to	to	IN
cord-295807-68sukdb1	700	43	their	-PRON-	PRP$
cord-295807-68sukdb1	700	44	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	700	45	targets	target	NNS
cord-295807-68sukdb1	700	46	in	in	IN
cord-295807-68sukdb1	700	47	the	the	DT
cord-295807-68sukdb1	700	48	nephron	nephron	NNP
cord-295807-68sukdb1	700	49	lumen	lumen	NN
cord-295807-68sukdb1	700	50	.	.	.
cord-295807-68sukdb1	701	1	The	the	DT
cord-295807-68sukdb1	701	2	direct	direct	JJ
cord-295807-68sukdb1	701	3	secretion	secretion	NN
cord-295807-68sukdb1	701	4	of	of	IN
cord-295807-68sukdb1	701	5	these	these	DT
cord-295807-68sukdb1	701	6	drugs	drug	NNS
cord-295807-68sukdb1	701	7	into	into	IN
cord-295807-68sukdb1	701	8	the	the	DT
cord-295807-68sukdb1	701	9	nephron	nephron	NNP
cord-295807-68sukdb1	701	10	lumen	lumen	NN
cord-295807-68sukdb1	701	11	is	be	VBZ
cord-295807-68sukdb1	701	12	necessary	necessary	JJ
cord-295807-68sukdb1	701	13	because	because	IN
cord-295807-68sukdb1	701	14	many	many	JJ
cord-295807-68sukdb1	701	15	such	such	JJ
cord-295807-68sukdb1	701	16	drugs	drug	NNS
cord-295807-68sukdb1	701	17	are	be	VBP
cord-295807-68sukdb1	701	18	substantially	substantially	RB
cord-295807-68sukdb1	701	19	bound	bind	VBN
cord-295807-68sukdb1	701	20	to	to	IN
cord-295807-68sukdb1	701	21	albumin	albumin	NN
cord-295807-68sukdb1	701	22	in	in	IN
cord-295807-68sukdb1	701	23	circulation	circulation	NN
cord-295807-68sukdb1	701	24	and	and	CC
cord-295807-68sukdb1	701	25	are	be	VBP
cord-295807-68sukdb1	701	26	not	not	RB
cord-295807-68sukdb1	701	27	effectively	effectively	RB
cord-295807-68sukdb1	701	28	filtered	filter	VBN
cord-295807-68sukdb1	701	29	into	into	IN
cord-295807-68sukdb1	701	30	the	the	DT
cord-295807-68sukdb1	701	31	nephron	nephron	NNP
cord-295807-68sukdb1	701	32	lumen	lumen	NN
cord-295807-68sukdb1	701	33	at	at	IN
cord-295807-68sukdb1	701	34	the	the	DT
cord-295807-68sukdb1	701	35	glomerulus	glomerulus	NN
cord-295807-68sukdb1	701	36	.	.	.
cord-295807-68sukdb1	702	1	6.6	6.6	CD
cord-295807-68sukdb1	702	2	Exploiting	exploit	VBG
cord-295807-68sukdb1	702	3	pH	ph	NN
cord-295807-68sukdb1	702	4	for	for	IN
cord-295807-68sukdb1	702	5	targeted	targeted	JJ
cord-295807-68sukdb1	702	6	drug	drug	NN
cord-295807-68sukdb1	702	7	delivery	delivery	NN
cord-295807-68sukdb1	702	8	Acidity	acidity	NN
cord-295807-68sukdb1	702	9	can	can	MD
cord-295807-68sukdb1	702	10	be	be	VB
cord-295807-68sukdb1	702	11	harnessed	harness	VBN
cord-295807-68sukdb1	702	12	to	to	TO
cord-295807-68sukdb1	702	13	target	target	VB
cord-295807-68sukdb1	702	14	drug	drug	NN
cord-295807-68sukdb1	702	15	release	release	NN
cord-295807-68sukdb1	702	16	to	to	IN
cord-295807-68sukdb1	702	17	acidic	acidic	JJ
cord-295807-68sukdb1	702	18	environments	environment	NNS
cord-295807-68sukdb1	702	19	such	such	JJ
cord-295807-68sukdb1	702	20	as	as	IN
cord-295807-68sukdb1	702	21	the	the	DT
cord-295807-68sukdb1	702	22	stomach	stomach	NN
cord-295807-68sukdb1	702	23	or	or	CC
cord-295807-68sukdb1	702	24	pathological	pathological	JJ
cord-295807-68sukdb1	702	25	acidotic	acidotic	JJ
cord-295807-68sukdb1	702	26	microenvironments	microenvironment	NNS
cord-295807-68sukdb1	702	27	such	such	JJ
cord-295807-68sukdb1	702	28	as	as	IN
cord-295807-68sukdb1	702	29	tumors	tumor	NNS
cord-295807-68sukdb1	702	30	.	.	.
cord-295807-68sukdb1	703	1	One	one	CD
cord-295807-68sukdb1	703	2	example	example	NN
cord-295807-68sukdb1	703	3	under	under	IN
cord-295807-68sukdb1	703	4	development	development	NN
cord-295807-68sukdb1	703	5	is	be	VBZ
cord-295807-68sukdb1	703	6	a	a	DT
cord-295807-68sukdb1	703	7	gastro	gastro	JJ
cord-295807-68sukdb1	703	8	-	-	HYPH
cord-295807-68sukdb1	703	9	floating	float	VBG
cord-295807-68sukdb1	703	10	matrix	matrix	NN
cord-295807-68sukdb1	703	11	tablet	tablet	NN
cord-295807-68sukdb1	703	12	that	that	WDT
cord-295807-68sukdb1	703	13	contains	contain	VBZ
cord-295807-68sukdb1	703	14	adjuvant	adjuvant	JJ
cord-295807-68sukdb1	703	15	NaHCO3	nahco3	NN
cord-295807-68sukdb1	703	16	with	with	IN
cord-295807-68sukdb1	703	17	the	the	DT
cord-295807-68sukdb1	703	18	drug	drug	NN
cord-295807-68sukdb1	703	19	,	,	,
cord-295807-68sukdb1	703	20	produces	produce	VBZ
cord-295807-68sukdb1	703	21	CO2	co2	NN
cord-295807-68sukdb1	703	22	upon	upon	IN
cord-295807-68sukdb1	703	23	reaction	reaction	NN
cord-295807-68sukdb1	703	24	with	with	IN
cord-295807-68sukdb1	703	25	gastric	gastric	JJ
cord-295807-68sukdb1	703	26	acid	acid	NN
cord-295807-68sukdb1	703	27	causing	cause	VBG
cord-295807-68sukdb1	703	28	the	the	DT
cord-295807-68sukdb1	703	29	dosage	dosage	NN
cord-295807-68sukdb1	703	30	form	form	NN
cord-295807-68sukdb1	703	31	to	to	TO
cord-295807-68sukdb1	703	32	remain	remain	VB
cord-295807-68sukdb1	703	33	buoyant	buoyant	JJ
cord-295807-68sukdb1	703	34	in	in	IN
cord-295807-68sukdb1	703	35	the	the	DT
cord-295807-68sukdb1	703	36	stomach	stomach	NN
cord-295807-68sukdb1	703	37	for	for	IN
cord-295807-68sukdb1	703	38	prolonged	prolonged	JJ
cord-295807-68sukdb1	703	39	release	release	NN
cord-295807-68sukdb1	703	40	[	[	-LRB-
cord-295807-68sukdb1	703	41	469	469	CD
cord-295807-68sukdb1	703	42	]	]	-RRB-
cord-295807-68sukdb1	703	43	.	.	.
cord-295807-68sukdb1	704	1	Another	another	DT
cord-295807-68sukdb1	704	2	example	example	NN
cord-295807-68sukdb1	704	3	is	be	VBZ
cord-295807-68sukdb1	704	4	the	the	DT
cord-295807-68sukdb1	704	5	use	use	NN
cord-295807-68sukdb1	704	6	of	of	IN
cord-295807-68sukdb1	704	7	pH	ph	JJ
cord-295807-68sukdb1	704	8	-	-	JJ
cord-295807-68sukdb1	704	9	sensitive	sensitive	JJ
cord-295807-68sukdb1	704	10	vehicles	vehicle	NNS
cord-295807-68sukdb1	704	11	such	such	JJ
cord-295807-68sukdb1	704	12	as	as	IN
cord-295807-68sukdb1	704	13	micelles	micelle	NNS
cord-295807-68sukdb1	704	14	that	that	WDT
cord-295807-68sukdb1	704	15	could	could	MD
cord-295807-68sukdb1	704	16	release	release	VB
cord-295807-68sukdb1	704	17	cytotoxic	cytotoxic	JJ
cord-295807-68sukdb1	704	18	chemotherapeutic	chemotherapeutic	JJ
cord-295807-68sukdb1	704	19	agents	agent	NNS
cord-295807-68sukdb1	704	20	only	only	RB
cord-295807-68sukdb1	704	21	in	in	IN
cord-295807-68sukdb1	704	22	the	the	DT
cord-295807-68sukdb1	704	23	acidic	acidic	JJ
cord-295807-68sukdb1	704	24	tumor	tumor	NN
cord-295807-68sukdb1	704	25	environment	environment	NN
cord-295807-68sukdb1	704	26	[	[	-LRB-
cord-295807-68sukdb1	704	27	470	470	CD
cord-295807-68sukdb1	704	28	]	]	-RRB-
cord-295807-68sukdb1	704	29	.	.	.
cord-295807-68sukdb1	705	1	Similarly	similarly	RB
cord-295807-68sukdb1	705	2	,	,	,
cord-295807-68sukdb1	705	3	as	as	IN
cord-295807-68sukdb1	705	4	suggested	suggest	VBN
cord-295807-68sukdb1	705	5	by	by	IN
cord-295807-68sukdb1	705	6	the	the	DT
cord-295807-68sukdb1	705	7	disparity	disparity	NN
cord-295807-68sukdb1	705	8	between	between	IN
cord-295807-68sukdb1	705	9	the	the	DT
cord-295807-68sukdb1	705	10	usefulness	usefulness	NN
cord-295807-68sukdb1	705	11	of	of	IN
cord-295807-68sukdb1	705	12	an	an	DT
cord-295807-68sukdb1	705	13	anticancer	anticancer	JJ
cord-295807-68sukdb1	705	14	drug	drug	NN
cord-295807-68sukdb1	705	15	that	that	WDT
cord-295807-68sukdb1	705	16	was	be	VBD
cord-295807-68sukdb1	705	17	identified	identify	VBN
cord-295807-68sukdb1	705	18	in	in	IN
cord-295807-68sukdb1	705	19	an	an	DT
cord-295807-68sukdb1	705	20	in	in	FW
cord-295807-68sukdb1	705	21	vitro	vitro	FW
cord-295807-68sukdb1	705	22	screening	screening	NN
cord-295807-68sukdb1	705	23	performed	perform	VBN
cord-295807-68sukdb1	705	24	at	at	IN
cord-295807-68sukdb1	705	25	neutral	neutral	JJ
cord-295807-68sukdb1	705	26	pH	pH	NNP
cord-295807-68sukdb1	705	27	and	and	CC
cord-295807-68sukdb1	705	28	its	-PRON-	PRP$
cord-295807-68sukdb1	705	29	value	value	NN
cord-295807-68sukdb1	705	30	in	in	IN
cord-295807-68sukdb1	705	31	vivo	vivo	NN
cord-295807-68sukdb1	705	32	in	in	IN
cord-295807-68sukdb1	705	33	the	the	DT
cord-295807-68sukdb1	705	34	acidic	acidic	JJ
cord-295807-68sukdb1	705	35	tumor	tumor	NN
cord-295807-68sukdb1	705	36	microenvironment	microenvironment	NN
cord-295807-68sukdb1	705	37	[	[	-LRB-
cord-295807-68sukdb1	705	38	471	471	CD
cord-295807-68sukdb1	705	39	]	]	-RRB-
cord-295807-68sukdb1	705	40	,	,	,
cord-295807-68sukdb1	705	41	it	-PRON-	PRP
cord-295807-68sukdb1	705	42	is	be	VBZ
cord-295807-68sukdb1	705	43	possible	possible	JJ
cord-295807-68sukdb1	705	44	that	that	IN
cord-295807-68sukdb1	705	45	some	some	DT
cord-295807-68sukdb1	705	46	drugs	drug	NNS
cord-295807-68sukdb1	705	47	may	may	MD
cord-295807-68sukdb1	705	48	be	be	VB
cord-295807-68sukdb1	705	49	inactive	inactive	JJ
cord-295807-68sukdb1	705	50	in	in	IN
cord-295807-68sukdb1	705	51	circulation	circulation	NN
cord-295807-68sukdb1	705	52	and	and	CC
cord-295807-68sukdb1	705	53	may	may	MD
cord-295807-68sukdb1	705	54	not	not	RB
cord-295807-68sukdb1	705	55	be	be	VB
cord-295807-68sukdb1	705	56	activated	activate	VBN
cord-295807-68sukdb1	705	57	until	until	IN
cord-295807-68sukdb1	705	58	they	-PRON-	PRP
cord-295807-68sukdb1	705	59	reach	reach	VBP
cord-295807-68sukdb1	705	60	an	an	DT
cord-295807-68sukdb1	705	61	acidic	acidic	JJ
cord-295807-68sukdb1	705	62	environment	environment	NN
cord-295807-68sukdb1	705	63	.	.	.
cord-295807-68sukdb1	706	1	ABTs	ABTs	NNP
cord-295807-68sukdb1	706	2	and	and	CC
cord-295807-68sukdb1	706	3	CAs	CAs	NNP
cord-295807-68sukdb1	706	4	play	play	VBP
cord-295807-68sukdb1	706	5	major	major	JJ
cord-295807-68sukdb1	706	6	roles	role	NNS
cord-295807-68sukdb1	706	7	in	in	IN
cord-295807-68sukdb1	706	8	a	a	DT
cord-295807-68sukdb1	706	9	variety	variety	NN
cord-295807-68sukdb1	706	10	of	of	IN
cord-295807-68sukdb1	706	11	pathologies	pathology	NNS
cord-295807-68sukdb1	706	12	and	and	CC
cord-295807-68sukdb1	706	13	provide	provide	VB
cord-295807-68sukdb1	706	14	an	an	DT
cord-295807-68sukdb1	706	15	array	array	NN
cord-295807-68sukdb1	706	16	of	of	IN
cord-295807-68sukdb1	706	17	potential	potential	JJ
cord-295807-68sukdb1	706	18	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	706	19	targets	target	NNS
cord-295807-68sukdb1	706	20	,	,	,
cord-295807-68sukdb1	706	21	but	but	CC
cord-295807-68sukdb1	706	22	many	many	JJ
cord-295807-68sukdb1	706	23	are	be	VBP
cord-295807-68sukdb1	706	24	currently	currently	RB
cord-295807-68sukdb1	706	25	lacking	lack	VBG
cord-295807-68sukdb1	706	26	specific	specific	JJ
cord-295807-68sukdb1	706	27	or	or	CC
cord-295807-68sukdb1	706	28	safe	safe	JJ
cord-295807-68sukdb1	706	29	drugs	drug	NNS
cord-295807-68sukdb1	706	30	.	.	.
cord-295807-68sukdb1	707	1	The	the	DT
cord-295807-68sukdb1	707	2	application	application	NN
cord-295807-68sukdb1	707	3	of	of	IN
cord-295807-68sukdb1	707	4	epigenetic	epigenetic	JJ
cord-295807-68sukdb1	707	5	modulators	modulator	NNS
cord-295807-68sukdb1	707	6	and	and	CC
cord-295807-68sukdb1	707	7	other	other	JJ
cord-295807-68sukdb1	707	8	genetic	genetic	JJ
cord-295807-68sukdb1	707	9	tools	tool	NNS
cord-295807-68sukdb1	707	10	to	to	TO
cord-295807-68sukdb1	707	11	alter	alter	VB
cord-295807-68sukdb1	707	12	their	-PRON-	PRP$
cord-295807-68sukdb1	707	13	expression	expression	NN
cord-295807-68sukdb1	707	14	is	be	VBZ
cord-295807-68sukdb1	707	15	an	an	DT
cord-295807-68sukdb1	707	16	underexplored	underexplored	JJ
cord-295807-68sukdb1	707	17	area	area	NN
cord-295807-68sukdb1	707	18	of	of	IN
cord-295807-68sukdb1	707	19	research	research	NN
cord-295807-68sukdb1	707	20	.	.	.
cord-295807-68sukdb1	708	1	It	-PRON-	PRP
cord-295807-68sukdb1	708	2	is	be	VBZ
cord-295807-68sukdb1	708	3	interesting	interesting	JJ
cord-295807-68sukdb1	708	4	to	to	TO
cord-295807-68sukdb1	708	5	note	note	VB
cord-295807-68sukdb1	708	6	that	that	IN
cord-295807-68sukdb1	708	7	,	,	,
cord-295807-68sukdb1	708	8	among	among	IN
cord-295807-68sukdb1	708	9	the	the	DT
cord-295807-68sukdb1	708	10	many	many	JJ
cord-295807-68sukdb1	708	11	treatment	treatment	NN
cord-295807-68sukdb1	708	12	paradigms	paradigm	NNS
cord-295807-68sukdb1	708	13	for	for	IN
cord-295807-68sukdb1	708	14	diverse	diverse	JJ
cord-295807-68sukdb1	708	15	acid	acid	JJ
cord-295807-68sukdb1	708	16	disturbances	disturbance	NNS
cord-295807-68sukdb1	708	17	,	,	,
cord-295807-68sukdb1	708	18	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	708	19	administration	administration	NN
cord-295807-68sukdb1	708	20	is	be	VBZ
cord-295807-68sukdb1	708	21	a	a	DT
cord-295807-68sukdb1	708	22	common	common	JJ
cord-295807-68sukdb1	708	23	thread	thread	NN
cord-295807-68sukdb1	708	24	.	.	.
cord-295807-68sukdb1	709	1	Its	-PRON-	PRP$
cord-295807-68sukdb1	709	2	low	low	JJ
cord-295807-68sukdb1	709	3	cost	cost	NN
cord-295807-68sukdb1	709	4	and	and	CC
cord-295807-68sukdb1	709	5	ready	ready	JJ
cord-295807-68sukdb1	709	6	availability	availability	NN
cord-295807-68sukdb1	709	7	have	have	VBP
cord-295807-68sukdb1	709	8	prompted	prompt	VBN
cord-295807-68sukdb1	709	9	its	-PRON-	PRP$
cord-295807-68sukdb1	709	10	nickname	nickname	NN
cord-295807-68sukdb1	709	11	"	"	``
cord-295807-68sukdb1	709	12	enemy	enemy	NN
cord-295807-68sukdb1	709	13	of	of	IN
cord-295807-68sukdb1	709	14	the	the	DT
cord-295807-68sukdb1	709	15	pharmaceutical	pharmaceutical	JJ
cord-295807-68sukdb1	709	16	industry	industry	NN
cord-295807-68sukdb1	709	17	.	.	.
cord-295807-68sukdb1	709	18	"	"	''
cord-295807-68sukdb1	710	1	However	however	RB
cord-295807-68sukdb1	710	2	,	,	,
cord-295807-68sukdb1	710	3	despite	despite	IN
cord-295807-68sukdb1	710	4	the	the	DT
cord-295807-68sukdb1	710	5	promise	promise	NN
cord-295807-68sukdb1	710	6	of	of	IN
cord-295807-68sukdb1	710	7	numerous	numerous	JJ
cord-295807-68sukdb1	710	8	limited	limited	JJ
cord-295807-68sukdb1	710	9	trials	trial	NNS
cord-295807-68sukdb1	710	10	,	,	,
cord-295807-68sukdb1	710	11	robust	robust	JJ
cord-295807-68sukdb1	710	12	evidence	evidence	NN
cord-295807-68sukdb1	710	13	in	in	IN
cord-295807-68sukdb1	710	14	favor	favor	NN
cord-295807-68sukdb1	710	15	of	of	IN
cord-295807-68sukdb1	710	16	its	-PRON-	PRP$
cord-295807-68sukdb1	710	17	broad	broad	JJ
cord-295807-68sukdb1	710	18	effectiveness	effectiveness	NN
cord-295807-68sukdb1	710	19	in	in	IN
cord-295807-68sukdb1	710	20	many	many	JJ
cord-295807-68sukdb1	710	21	fields	field	NNS
cord-295807-68sukdb1	710	22	is	be	VBZ
cord-295807-68sukdb1	710	23	currently	currently	RB
cord-295807-68sukdb1	710	24	lacking	lack	VBG
cord-295807-68sukdb1	710	25	.	.	.
cord-295807-68sukdb1	711	1	This	this	DT
cord-295807-68sukdb1	711	2	is	be	VBZ
cord-295807-68sukdb1	711	3	perhaps	perhaps	RB
cord-295807-68sukdb1	711	4	due	due	IN
cord-295807-68sukdb1	711	5	to	to	IN
cord-295807-68sukdb1	711	6	a	a	DT
cord-295807-68sukdb1	711	7	lack	lack	NN
cord-295807-68sukdb1	711	8	of	of	IN
cord-295807-68sukdb1	711	9	appreciation	appreciation	NN
cord-295807-68sukdb1	711	10	of	of	IN
cord-295807-68sukdb1	711	11	subgroup	subgroup	NN
cord-295807-68sukdb1	711	12	effects	effect	NNS
cord-295807-68sukdb1	711	13	or	or	CC
cord-295807-68sukdb1	711	14	a	a	DT
cord-295807-68sukdb1	711	15	lack	lack	NN
cord-295807-68sukdb1	711	16	of	of	IN
cord-295807-68sukdb1	711	17	standardization	standardization	NN
cord-295807-68sukdb1	711	18	among	among	IN
cord-295807-68sukdb1	711	19	trails	trail	NNS
cord-295807-68sukdb1	711	20	.	.	.
cord-295807-68sukdb1	712	1	Nonetheless	nonetheless	RB
cord-295807-68sukdb1	712	2	,	,	,
cord-295807-68sukdb1	712	3	research	research	NN
cord-295807-68sukdb1	712	4	into	into	IN
cord-295807-68sukdb1	712	5	the	the	DT
cord-295807-68sukdb1	712	6	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	712	7	importance	importance	NN
cord-295807-68sukdb1	712	8	of	of	IN
cord-295807-68sukdb1	712	9	balancing	balance	VBG
cord-295807-68sukdb1	712	10	pH	pH	NNP
cord-295807-68sukdb1	712	11	remains	remain	VBZ
cord-295807-68sukdb1	712	12	robust	robust	JJ
cord-295807-68sukdb1	712	13	and	and	CC
cord-295807-68sukdb1	712	14	promises	promise	VBZ
cord-295807-68sukdb1	712	15	the	the	DT
cord-295807-68sukdb1	712	16	delivery	delivery	NN
cord-295807-68sukdb1	712	17	of	of	IN
cord-295807-68sukdb1	712	18	many	many	JJ
cord-295807-68sukdb1	712	19	more	more	JJR
cord-295807-68sukdb1	712	20	effective	effective	JJ
cord-295807-68sukdb1	712	21	treatments	treatment	NNS
cord-295807-68sukdb1	712	22	in	in	IN
cord-295807-68sukdb1	712	23	the	the	DT
cord-295807-68sukdb1	712	24	coming	come	VBG
cord-295807-68sukdb1	712	25	years	year	NNS
cord-295807-68sukdb1	712	26	.	.	.
cord-295807-68sukdb1	713	1	Figure	figure	NN
cord-295807-68sukdb1	713	2	5	5	CD
cord-295807-68sukdb1	713	3	.	.	.
cord-295807-68sukdb1	714	1	Targeting	target	VBG
cord-295807-68sukdb1	714	2	carbonic	carbonic	JJ
cord-295807-68sukdb1	714	3	anhydrase	anhydrase	NN
cord-295807-68sukdb1	714	4	to	to	TO
cord-295807-68sukdb1	714	5	treat	treat	VB
cord-295807-68sukdb1	714	6	glaucoma	glaucoma	NN
cord-295807-68sukdb1	714	7	.	.	.
cord-295807-68sukdb1	715	1	Glaucoma	glaucoma	NN
cord-295807-68sukdb1	715	2	is	be	VBZ
cord-295807-68sukdb1	715	3	retinal	retinal	JJ
cord-295807-68sukdb1	715	4	degeneration	degeneration	NN
cord-295807-68sukdb1	715	5	caused	cause	VBN
cord-295807-68sukdb1	715	6	by	by	IN
cord-295807-68sukdb1	715	7	increased	increase	VBN
cord-295807-68sukdb1	715	8	intralocular	intralocular	JJ
cord-295807-68sukdb1	715	9	pressure	pressure	NN
cord-295807-68sukdb1	715	10	.	.	.
cord-295807-68sukdb1	716	1	Eye	eye	NN
cord-295807-68sukdb1	716	2	drops	drop	NNS
cord-295807-68sukdb1	716	3	containing	contain	VBG
cord-295807-68sukdb1	716	4	CA	CA	NNP
cord-295807-68sukdb1	716	5	-	-	HYPH
cord-295807-68sukdb1	716	6	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	716	7	such	such	JJ
cord-295807-68sukdb1	716	8	as	as	IN
cord-295807-68sukdb1	716	9	acetazolamide	acetazolamide	NNP
cord-295807-68sukdb1	716	10	(	(	-LRB-
cord-295807-68sukdb1	716	11	ACZ	ACZ	NNP
cord-295807-68sukdb1	716	12	)	)	-RRB-
cord-295807-68sukdb1	716	13	target	target	NN
cord-295807-68sukdb1	716	14	CAs	CAs	NNP
cord-295807-68sukdb1	716	15	in	in	IN
cord-295807-68sukdb1	716	16	the	the	DT
cord-295807-68sukdb1	716	17	ciliary	ciliary	NN
cord-295807-68sukdb1	716	18	body	body	NN
cord-295807-68sukdb1	716	19	and	and	CC
cord-295807-68sukdb1	716	20	reduce	reduce	VB
cord-295807-68sukdb1	716	21	the	the	DT
cord-295807-68sukdb1	716	22	production	production	NN
cord-295807-68sukdb1	716	23	of	of	IN
cord-295807-68sukdb1	716	24	aqueous	aqueous	JJ
cord-295807-68sukdb1	716	25	humor	humor	NN
cord-295807-68sukdb1	716	26	,	,	,
cord-295807-68sukdb1	716	27	lowering	lower	VBG
cord-295807-68sukdb1	716	28	intraocular	intraocular	JJ
cord-295807-68sukdb1	716	29	pressure	pressure	NN
cord-295807-68sukdb1	716	30	.	.	.
cord-295807-68sukdb1	717	1	The	the	DT
cord-295807-68sukdb1	717	2	ciliary	ciliary	NN
cord-295807-68sukdb1	717	3	body	body	NN
cord-295807-68sukdb1	717	4	is	be	VBZ
cord-295807-68sukdb1	717	5	a	a	DT
cord-295807-68sukdb1	717	6	complex	complex	JJ
cord-295807-68sukdb1	717	7	epithelial	epithelial	JJ
cord-295807-68sukdb1	717	8	tissue	tissue	NN
cord-295807-68sukdb1	717	9	comprised	comprise	VBN
cord-295807-68sukdb1	717	10	of	of	IN
cord-295807-68sukdb1	717	11	two	two	CD
cord-295807-68sukdb1	717	12	cell	cell	NN
cord-295807-68sukdb1	717	13	layers	layer	NNS
cord-295807-68sukdb1	717	14	joined	join	VBN
cord-295807-68sukdb1	717	15	by	by	IN
cord-295807-68sukdb1	717	16	gap	gap	NN
cord-295807-68sukdb1	717	17	junctions	junction	NNS
cord-295807-68sukdb1	717	18	.	.	.
cord-295807-68sukdb1	718	1	A	a	DT
cord-295807-68sukdb1	718	2	variety	variety	NN
cord-295807-68sukdb1	718	3	of	of	IN
cord-295807-68sukdb1	718	4	ABTs	abt	NNS
cord-295807-68sukdb1	718	5	and	and	CC
cord-295807-68sukdb1	718	6	other	other	JJ
cord-295807-68sukdb1	718	7	transporters	transporter	NNS
cord-295807-68sukdb1	718	8	are	be	VBP
cord-295807-68sukdb1	718	9	required	require	VBN
cord-295807-68sukdb1	718	10	to	to	TO
cord-295807-68sukdb1	718	11	move	move	VB
cord-295807-68sukdb1	718	12	NaCl	NaCl	NNP
cord-295807-68sukdb1	718	13	,	,	,
cord-295807-68sukdb1	718	14	which	which	WDT
cord-295807-68sukdb1	718	15	is	be	VBZ
cord-295807-68sukdb1	718	16	followed	follow	VBN
cord-295807-68sukdb1	718	17	by	by	IN
cord-295807-68sukdb1	718	18	water	water	NN
cord-295807-68sukdb1	718	19	,	,	,
cord-295807-68sukdb1	718	20	from	from	IN
cord-295807-68sukdb1	718	21	the	the	DT
cord-295807-68sukdb1	718	22	interstitial	interstitial	JJ
cord-295807-68sukdb1	718	23	fluid	fluid	NN
cord-295807-68sukdb1	718	24	into	into	IN
cord-295807-68sukdb1	718	25	the	the	DT
cord-295807-68sukdb1	718	26	anterior	anterior	NNP
cord-295807-68sukdb1	718	27	chamber	chamber	NN
cord-295807-68sukdb1	718	28	of	of	IN
cord-295807-68sukdb1	718	29	the	the	DT
cord-295807-68sukdb1	718	30	eye	eye	NN
cord-295807-68sukdb1	718	31	.	.	.
cord-295807-68sukdb1	719	1	Figure	figure	NN
cord-295807-68sukdb1	719	2	6	6	CD
cord-295807-68sukdb1	719	3	.	.	.
cord-295807-68sukdb1	720	1	Enhancing	enhance	VBG
cord-295807-68sukdb1	720	2	fluid	fluid	JJ
cord-295807-68sukdb1	720	3	secretion	secretion	NN
cord-295807-68sukdb1	720	4	in	in	IN
cord-295807-68sukdb1	720	5	the	the	DT
cord-295807-68sukdb1	720	6	lungs	lung	NNS
cord-295807-68sukdb1	720	7	.	.	.
cord-295807-68sukdb1	721	1	CFTR	CFTR	NNP
cord-295807-68sukdb1	721	2	promotes	promote	VBZ
cord-295807-68sukdb1	721	3	the	the	DT
cord-295807-68sukdb1	721	4	movement	movement	NN
cord-295807-68sukdb1	721	5	of	of	IN
cord-295807-68sukdb1	721	6	HCO3	HCO3	NNP
cord-295807-68sukdb1	721	7	-containing	-containe	VBG
cord-295807-68sukdb1	721	8	fluid	fluid	NN
cord-295807-68sukdb1	721	9	onto	onto	IN
cord-295807-68sukdb1	721	10	the	the	DT
cord-295807-68sukdb1	721	11	airway	airway	NN
cord-295807-68sukdb1	721	12	surface	surface	NN
cord-295807-68sukdb1	721	13	to	to	TO
cord-295807-68sukdb1	721	14	promote	promote	VB
cord-295807-68sukdb1	721	15	mucociliary	mucociliary	JJ
cord-295807-68sukdb1	721	16	clearance	clearance	NN
cord-295807-68sukdb1	721	17	and	and	CC
cord-295807-68sukdb1	721	18	lung	lung	NN
cord-295807-68sukdb1	721	19	health	health	NN
cord-295807-68sukdb1	721	20	.	.	.
cord-295807-68sukdb1	722	1	Drugs	drug	NNS
cord-295807-68sukdb1	722	2	such	such	JJ
cord-295807-68sukdb1	722	3	as	as	IN
cord-295807-68sukdb1	722	4	lumacaftor	lumacaftor	NN
cord-295807-68sukdb1	722	5	/	/	SYM
cord-295807-68sukdb1	722	6	ivacaftor	ivacaftor	NN
cord-295807-68sukdb1	722	7	rescue	rescue	NN
cord-295807-68sukdb1	722	8	this	this	DT
cord-295807-68sukdb1	722	9	function	function	NN
cord-295807-68sukdb1	722	10	in	in	IN
cord-295807-68sukdb1	722	11	some	some	DT
cord-295807-68sukdb1	722	12	individuals	individual	NNS
cord-295807-68sukdb1	722	13	with	with	IN
cord-295807-68sukdb1	722	14	CF	CF	NNP
cord-295807-68sukdb1	722	15	by	by	IN
cord-295807-68sukdb1	722	16	helping	help	VBG
cord-295807-68sukdb1	722	17	misfolded	misfolde	VBN
cord-295807-68sukdb1	722	18	CFTR	CFTR	NNP
cord-295807-68sukdb1	722	19	molecules	molecule	NNS
cord-295807-68sukdb1	722	20	to	to	TO
cord-295807-68sukdb1	722	21	function	function	VB
cord-295807-68sukdb1	722	22	normally	normally	RB
cord-295807-68sukdb1	722	23	.	.	.
cord-295807-68sukdb1	723	1	Alternative	alternative	JJ
cord-295807-68sukdb1	723	2	pH	ph	NN
cord-295807-68sukdb1	723	3	-	-	HYPH
cord-295807-68sukdb1	723	4	based	base	VBN
cord-295807-68sukdb1	723	5	strategies	strategy	NNS
cord-295807-68sukdb1	723	6	have	have	VBP
cord-295807-68sukdb1	723	7	been	be	VBN
cord-295807-68sukdb1	723	8	suggested	suggest	VBN
cord-295807-68sukdb1	723	9	as	as	IN
cord-295807-68sukdb1	723	10	adjunct	adjunct	NN
cord-295807-68sukdb1	723	11	CF	cf	NN
cord-295807-68sukdb1	723	12	therapy	therapy	NN
cord-295807-68sukdb1	723	13	,	,	,
cord-295807-68sukdb1	723	14	such	such	JJ
cord-295807-68sukdb1	723	15	as	as	IN
cord-295807-68sukdb1	723	16	blockade	blockade	NN
cord-295807-68sukdb1	723	17	of	of	IN
cord-295807-68sukdb1	723	18	the	the	DT
cord-295807-68sukdb1	723	19	many	many	JJ
cord-295807-68sukdb1	723	20	H	h	NN
cord-295807-68sukdb1	723	21	+	+	CC
cord-295807-68sukdb1	723	22	secreting	secrete	VBG
cord-295807-68sukdb1	723	23	ABTs	abt	NNS
cord-295807-68sukdb1	723	24	.	.	.
cord-295807-68sukdb1	724	1	Figure	figure	NN
cord-295807-68sukdb1	724	2	7	7	CD
cord-295807-68sukdb1	724	3	.	.	.
cord-295807-68sukdb1	725	1	The	the	DT
cord-295807-68sukdb1	725	2	Bohr	Bohr	NNP
cord-295807-68sukdb1	725	3	Effect	Effect	NNP
cord-295807-68sukdb1	725	4	.	.	.
cord-295807-68sukdb1	726	1	The	the	DT
cord-295807-68sukdb1	726	2	action	action	NN
cord-295807-68sukdb1	726	3	of	of	IN
cord-295807-68sukdb1	726	4	AE1	AE1	NNP
cord-295807-68sukdb1	726	5	and	and	CC
cord-295807-68sukdb1	726	6	CAs	CAs	NNP
cord-295807-68sukdb1	726	7	promote	promote	VBP
cord-295807-68sukdb1	726	8	O2	O2	NNP
cord-295807-68sukdb1	726	9	release	release	NN
cord-295807-68sukdb1	726	10	in	in	IN
cord-295807-68sukdb1	726	11	systemic	systemic	JJ
cord-295807-68sukdb1	726	12	capillaries	capillary	NNS
cord-295807-68sukdb1	726	13	(	(	-LRB-
cord-295807-68sukdb1	726	14	panel	panel	NN
cord-295807-68sukdb1	726	15	A	A	NNP
cord-295807-68sukdb1	726	16	)	)	-RRB-
cord-295807-68sukdb1	726	17	and	and	CC
cord-295807-68sukdb1	726	18	CO2	CO2	NNP
cord-295807-68sukdb1	726	19	release	release	NN
cord-295807-68sukdb1	726	20	in	in	IN
cord-295807-68sukdb1	726	21	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	726	22	capillaries	capillary	NNS
cord-295807-68sukdb1	726	23	because	because	IN
cord-295807-68sukdb1	726	24	of	of	IN
cord-295807-68sukdb1	726	25	the	the	DT
cord-295807-68sukdb1	726	26	pH	ph	NN
cord-295807-68sukdb1	726	27	-	-	NN
cord-295807-68sukdb1	726	28	dependence	dependence	NN
cord-295807-68sukdb1	726	29	of	of	IN
cord-295807-68sukdb1	726	30	the	the	DT
cord-295807-68sukdb1	726	31	affinity	affinity	NN
cord-295807-68sukdb1	726	32	of	of	IN
cord-295807-68sukdb1	726	33	hemoglobin	hemoglobin	NN
cord-295807-68sukdb1	726	34	for	for	IN
cord-295807-68sukdb1	726	35	O2	O2	NNP
cord-295807-68sukdb1	726	36	(	(	-LRB-
cord-295807-68sukdb1	726	37	the	the	DT
cord-295807-68sukdb1	726	38	Bohr	Bohr	NNP
cord-295807-68sukdb1	726	39	effect	effect	NN
cord-295807-68sukdb1	726	40	)	)	-RRB-
cord-295807-68sukdb1	726	41	.	.	.
cord-295807-68sukdb1	727	1	Figure	figure	NN
cord-295807-68sukdb1	727	2	8	8	CD
cord-295807-68sukdb1	727	3	.	.	.
cord-295807-68sukdb1	728	1	The	the	DT
cord-295807-68sukdb1	728	2	role	role	NN
cord-295807-68sukdb1	728	3	of	of	IN
cord-295807-68sukdb1	728	4	ABTs	ABTs	NNP
cord-295807-68sukdb1	728	5	and	and	CC
cord-295807-68sukdb1	728	6	CAs	CAs	NNP
cord-295807-68sukdb1	728	7	in	in	IN
cord-295807-68sukdb1	728	8	bone	bone	NN
cord-295807-68sukdb1	728	9	remodeling	remodeling	NN
cord-295807-68sukdb1	728	10	.	.	.
cord-295807-68sukdb1	729	1	Osteoclasts	osteoclast	NNS
cord-295807-68sukdb1	729	2	secrete	secrete	VBP
cord-295807-68sukdb1	729	3	acid	acid	NN
cord-295807-68sukdb1	729	4	onto	onto	IN
cord-295807-68sukdb1	729	5	the	the	DT
cord-295807-68sukdb1	729	6	bone	bone	NN
cord-295807-68sukdb1	729	7	surface	surface	NN
cord-295807-68sukdb1	729	8	to	to	TO
cord-295807-68sukdb1	729	9	resorb	resorb	VB
cord-295807-68sukdb1	729	10	minerals	mineral	NNS
cord-295807-68sukdb1	729	11	during	during	IN
cord-295807-68sukdb1	729	12	bone	bone	NN
cord-295807-68sukdb1	729	13	growth	growth	NN
cord-295807-68sukdb1	729	14	/	/	SYM
cord-295807-68sukdb1	729	15	remodeling	remodeling	NN
cord-295807-68sukdb1	729	16	and	and	CC
cord-295807-68sukdb1	729	17	in	in	IN
cord-295807-68sukdb1	729	18	response	response	NN
cord-295807-68sukdb1	729	19	to	to	IN
cord-295807-68sukdb1	729	20	hormonal	hormonal	JJ
cord-295807-68sukdb1	729	21	requirements	requirement	NNS
cord-295807-68sukdb1	729	22	for	for	IN
cord-295807-68sukdb1	729	23	release	release	NN
cord-295807-68sukdb1	729	24	of	of	IN
cord-295807-68sukdb1	729	25	mineralized	mineralized	JJ
cord-295807-68sukdb1	729	26	Ca	Ca	NNP
cord-295807-68sukdb1	729	27	2	2	CD
cord-295807-68sukdb1	729	28	+	+	SYM
cord-295807-68sukdb1	729	29	and	and	CC
cord-295807-68sukdb1	729	30	phosphate	phosphate	NN
cord-295807-68sukdb1	729	31	.	.	.
cord-295807-68sukdb1	730	1	One	one	CD
cord-295807-68sukdb1	730	2	report	report	NN
cord-295807-68sukdb1	730	3	suggested	suggest	VBD
cord-295807-68sukdb1	730	4	an	an	DT
cord-295807-68sukdb1	730	5	off	off	JJ
cord-295807-68sukdb1	730	6	-	-	HYPH
cord-295807-68sukdb1	730	7	target	target	NN
cord-295807-68sukdb1	730	8	bone	bone	NN
cord-295807-68sukdb1	730	9	-	-	HYPH
cord-295807-68sukdb1	730	10	sparing	spare	VBG
cord-295807-68sukdb1	730	11	effect	effect	NN
cord-295807-68sukdb1	730	12	of	of	IN
cord-295807-68sukdb1	730	13	CA	CA	NNP
cord-295807-68sukdb1	730	14	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	730	15	,	,	,
cord-295807-68sukdb1	730	16	used	use	VBN
cord-295807-68sukdb1	730	17	to	to	TO
cord-295807-68sukdb1	730	18	treat	treat	VB
cord-295807-68sukdb1	730	19	glaucoma	glaucoma	NN
cord-295807-68sukdb1	730	20	,	,	,
cord-295807-68sukdb1	730	21	in	in	IN
cord-295807-68sukdb1	730	22	a	a	DT
cord-295807-68sukdb1	730	23	group	group	NN
cord-295807-68sukdb1	730	24	of	of	IN
cord-295807-68sukdb1	730	25	post	post	JJ
cord-295807-68sukdb1	730	26	-	-	JJ
cord-295807-68sukdb1	730	27	menopausal	menopausal	JJ
cord-295807-68sukdb1	730	28	women	woman	NNS
cord-295807-68sukdb1	730	29	.	.	.
cord-295807-68sukdb1	731	1	Figure	figure	NN
cord-295807-68sukdb1	731	2	9	9	CD
cord-295807-68sukdb1	731	3	.	.	.
cord-295807-68sukdb1	732	1	Targeting	target	VBG
cord-295807-68sukdb1	732	2	the	the	DT
cord-295807-68sukdb1	732	3	stomach	stomach	NN
cord-295807-68sukdb1	732	4	H	h	NN
cord-295807-68sukdb1	733	1	+	+	CC
cord-295807-68sukdb1	734	1	/K	/K	NNP
cord-295807-68sukdb1	734	2	+	+	CC
cord-295807-68sukdb1	735	1	-ATPase	-ATPase	NNP
cord-295807-68sukdb1	736	1	to	to	TO
cord-295807-68sukdb1	736	2	treat	treat	VB
cord-295807-68sukdb1	736	3	acid	acid	NN
cord-295807-68sukdb1	736	4	-	-	HYPH
cord-295807-68sukdb1	736	5	reflux	reflux	NN
cord-295807-68sukdb1	736	6	disease	disease	NN
cord-295807-68sukdb1	736	7	.	.	.
cord-295807-68sukdb1	737	1	Proton	proton	NN
cord-295807-68sukdb1	737	2	pump	pump	NN
cord-295807-68sukdb1	737	3	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	737	4	are	be	VBP
cord-295807-68sukdb1	737	5	widely	widely	RB
cord-295807-68sukdb1	737	6	used	use	VBN
cord-295807-68sukdb1	737	7	to	to	TO
cord-295807-68sukdb1	737	8	reduce	reduce	VB
cord-295807-68sukdb1	737	9	gastric	gastric	JJ
cord-295807-68sukdb1	737	10	acid	acid	NN
cord-295807-68sukdb1	737	11	secretion	secretion	NN
cord-295807-68sukdb1	737	12	,	,	,
cord-295807-68sukdb1	737	13	as	as	IN
cord-295807-68sukdb1	737	14	an	an	DT
cord-295807-68sukdb1	737	15	alternative	alternative	NN
cord-295807-68sukdb1	737	16	or	or	CC
cord-295807-68sukdb1	737	17	adjunct	adjunct	JJ
cord-295807-68sukdb1	737	18	strategy	strategy	NN
cord-295807-68sukdb1	737	19	to	to	IN
cord-295807-68sukdb1	737	20	neutralizing	neutralize	VBG
cord-295807-68sukdb1	737	21	stomach	stomach	NN
cord-295807-68sukdb1	737	22	acid	acid	NN
cord-295807-68sukdb1	737	23	with	with	IN
cord-295807-68sukdb1	737	24	an	an	DT
cord-295807-68sukdb1	737	25	antacid	antacid	NN
cord-295807-68sukdb1	737	26	such	such	JJ
cord-295807-68sukdb1	737	27	as	as	IN
cord-295807-68sukdb1	737	28	CaCO3	CaCO3	NNP
cord-295807-68sukdb1	737	29	.	.	.
cord-295807-68sukdb1	738	1	Figure	figure	NN
cord-295807-68sukdb1	738	2	10	10	CD
cord-295807-68sukdb1	738	3	.	.	.
cord-295807-68sukdb1	739	1	Targeting	target	VBG
cord-295807-68sukdb1	739	2	intestinal	intestinal	JJ
cord-295807-68sukdb1	739	3	ABTs	abt	NNS
cord-295807-68sukdb1	739	4	to	to	TO
cord-295807-68sukdb1	739	5	treat	treat	VB
cord-295807-68sukdb1	739	6	constipation	constipation	NN
cord-295807-68sukdb1	739	7	.	.	.
cord-295807-68sukdb1	740	1	Intestinal	intestinal	JJ
cord-295807-68sukdb1	740	2	fluid	fluid	JJ
cord-295807-68sukdb1	740	3	absorption	absorption	NN
cord-295807-68sukdb1	740	4	is	be	VBZ
cord-295807-68sukdb1	740	5	promoted	promote	VBN
cord-295807-68sukdb1	740	6	by	by	IN
cord-295807-68sukdb1	740	7	the	the	DT
cord-295807-68sukdb1	740	8	combined	combine	VBN
cord-295807-68sukdb1	740	9	action	action	NN
cord-295807-68sukdb1	740	10	of	of	IN
cord-295807-68sukdb1	740	11	NHE3	NHE3	NNP
cord-295807-68sukdb1	740	12	and	and	CC
cord-295807-68sukdb1	740	13	SLC26A3	SLC26A3	NNP
cord-295807-68sukdb1	740	14	,	,	,
cord-295807-68sukdb1	740	15	which	which	WDT
cord-295807-68sukdb1	740	16	perform	perform	VBP
cord-295807-68sukdb1	740	17	the	the	DT
cord-295807-68sukdb1	740	18	net	net	JJ
cord-295807-68sukdb1	740	19	uptake	uptake	NN
cord-295807-68sukdb1	740	20	of	of	IN
cord-295807-68sukdb1	740	21	NaCl	nacl	NN
cord-295807-68sukdb1	740	22	,	,	,
cord-295807-68sukdb1	740	23	and	and	CC
cord-295807-68sukdb1	740	24	therefore	therefore	RB
cord-295807-68sukdb1	740	25	water	water	NN
cord-295807-68sukdb1	740	26	.	.	.
cord-295807-68sukdb1	741	1	Inhibition	inhibition	NN
cord-295807-68sukdb1	741	2	of	of	IN
cord-295807-68sukdb1	741	3	either	either	DT
cord-295807-68sukdb1	741	4	,	,	,
cord-295807-68sukdb1	741	5	to	to	TO
cord-295807-68sukdb1	741	6	reduce	reduce	VB
cord-295807-68sukdb1	741	7	fluid	fluid	JJ
cord-295807-68sukdb1	741	8	absorption	absorption	NN
cord-295807-68sukdb1	741	9	from	from	IN
cord-295807-68sukdb1	741	10	the	the	DT
cord-295807-68sukdb1	741	11	intestinal	intestinal	JJ
cord-295807-68sukdb1	741	12	lumen	lumen	NN
cord-295807-68sukdb1	741	13	is	be	VBZ
cord-295807-68sukdb1	741	14	a	a	DT
cord-295807-68sukdb1	741	15	useful	useful	JJ
cord-295807-68sukdb1	741	16	therapy	therapy	NN
cord-295807-68sukdb1	741	17	for	for	IN
cord-295807-68sukdb1	741	18	irritable	irritable	JJ
cord-295807-68sukdb1	741	19	bowel	bowel	NN
cord-295807-68sukdb1	741	20	syndrome	syndrome	NN
cord-295807-68sukdb1	741	21	with	with	IN
cord-295807-68sukdb1	741	22	constipation	constipation	NN
cord-295807-68sukdb1	741	23	.	.	.
cord-295807-68sukdb1	742	1	Ivacaftor	Ivacaftor	NNP
cord-295807-68sukdb1	742	2	is	be	VBZ
cord-295807-68sukdb1	742	3	similarly	similarly	RB
cord-295807-68sukdb1	742	4	useful	useful	JJ
cord-295807-68sukdb1	742	5	in	in	IN
cord-295807-68sukdb1	742	6	CF	cf	NN
cord-295807-68sukdb1	742	7	by	by	IN
cord-295807-68sukdb1	742	8	restoring	restore	VBG
cord-295807-68sukdb1	742	9	intestinal	intestinal	JJ
cord-295807-68sukdb1	742	10	fluid	fluid	JJ
cord-295807-68sukdb1	742	11	secretion	secretion	NN
cord-295807-68sukdb1	742	12	.	.	.
cord-295807-68sukdb1	743	1	Figure	figure	NN
cord-295807-68sukdb1	743	2	11	11	CD
cord-295807-68sukdb1	743	3	.	.	.
cord-295807-68sukdb1	744	1	The	the	DT
cord-295807-68sukdb1	744	2	role	role	NN
cord-295807-68sukdb1	744	3	of	of	IN
cord-295807-68sukdb1	744	4	ABTs	ABTs	NNP
cord-295807-68sukdb1	744	5	and	and	CC
cord-295807-68sukdb1	744	6	CAs	CAs	NNP
cord-295807-68sukdb1	744	7	in	in	IN
cord-295807-68sukdb1	744	8	cancer	cancer	NN
cord-295807-68sukdb1	744	9	.	.	.
cord-295807-68sukdb1	745	1	Numerous	numerous	JJ
cord-295807-68sukdb1	745	2	acid	acid	NN
cord-295807-68sukdb1	745	3	-	-	HYPH
cord-295807-68sukdb1	745	4	base	base	NN
cord-295807-68sukdb1	745	5	handling	handling	NN
cord-295807-68sukdb1	745	6	proteins	protein	NNS
cord-295807-68sukdb1	745	7	are	be	VBP
cord-295807-68sukdb1	745	8	upregulated	upregulate	VBN
cord-295807-68sukdb1	745	9	in	in	IN
cord-295807-68sukdb1	745	10	rapidly	rapidly	RB
cord-295807-68sukdb1	745	11	proliferating	proliferate	VBG
cord-295807-68sukdb1	745	12	tumor	tumor	NN
cord-295807-68sukdb1	745	13	calls	call	NNS
cord-295807-68sukdb1	745	14	to	to	TO
cord-295807-68sukdb1	745	15	help	help	VB
cord-295807-68sukdb1	745	16	them	-PRON-	PRP
cord-295807-68sukdb1	745	17	dispose	dispose	VB
cord-295807-68sukdb1	745	18	of	of	IN
cord-295807-68sukdb1	745	19	metabolic	metabolic	JJ
cord-295807-68sukdb1	745	20	acids	acid	NNS
cord-295807-68sukdb1	745	21	and	and	CC
cord-295807-68sukdb1	745	22	create	create	VB
cord-295807-68sukdb1	745	23	an	an	DT
cord-295807-68sukdb1	745	24	acidic	acidic	JJ
cord-295807-68sukdb1	745	25	microenvironment	microenvironment	NN
cord-295807-68sukdb1	745	26	that	that	WDT
cord-295807-68sukdb1	745	27	disadvantages	disadvantage	VBZ
cord-295807-68sukdb1	745	28	non	non	JJ
cord-295807-68sukdb1	745	29	-	-	JJ
cord-295807-68sukdb1	745	30	tumor	tumor	JJ
cord-295807-68sukdb1	745	31	cells	cell	NNS
cord-295807-68sukdb1	745	32	in	in	IN
cord-295807-68sukdb1	745	33	their	-PRON-	PRP$
cord-295807-68sukdb1	745	34	vicinity	vicinity	NN
cord-295807-68sukdb1	745	35	.	.	.
cord-295807-68sukdb1	746	1	As	as	IN
cord-295807-68sukdb1	746	2	most	most	JJS
cord-295807-68sukdb1	746	3	of	of	IN
cord-295807-68sukdb1	746	4	these	these	DT
cord-295807-68sukdb1	746	5	ABTs	abt	NNS
cord-295807-68sukdb1	746	6	and	and	CC
cord-295807-68sukdb1	746	7	CAs	CAs	NNP
cord-295807-68sukdb1	746	8	are	be	VBP
cord-295807-68sukdb1	746	9	gainfully	gainfully	RB
cord-295807-68sukdb1	746	10	expressed	express	VBN
cord-295807-68sukdb1	746	11	elsewhere	elsewhere	RB
cord-295807-68sukdb1	746	12	in	in	IN
cord-295807-68sukdb1	746	13	the	the	DT
cord-295807-68sukdb1	746	14	body	body	NN
cord-295807-68sukdb1	746	15	,	,	,
cord-295807-68sukdb1	746	16	therapies	therapy	NNS
cord-295807-68sukdb1	746	17	in	in	IN
cord-295807-68sukdb1	746	18	development	development	NN
cord-295807-68sukdb1	746	19	are	be	VBP
cord-295807-68sukdb1	746	20	focused	focus	VBN
cord-295807-68sukdb1	746	21	on	on	IN
cord-295807-68sukdb1	746	22	blocking	block	VBG
cord-295807-68sukdb1	746	23	those	those	DT
cord-295807-68sukdb1	746	24	rarer	rare	JJR
cord-295807-68sukdb1	746	25	targets	target	NNS
cord-295807-68sukdb1	746	26	that	that	WDT
cord-295807-68sukdb1	746	27	are	be	VBP
cord-295807-68sukdb1	746	28	preferentially	preferentially	RB
cord-295807-68sukdb1	746	29	expressed	express	VBN
cord-295807-68sukdb1	746	30	in	in	IN
cord-295807-68sukdb1	746	31	the	the	DT
cord-295807-68sukdb1	746	32	hypoxic	hypoxic	JJ
cord-295807-68sukdb1	746	33	tumor	tumor	NN
cord-295807-68sukdb1	746	34	environment	environment	NN
cord-295807-68sukdb1	746	35	such	such	JJ
cord-295807-68sukdb1	746	36	as	as	IN
cord-295807-68sukdb1	746	37	MCT4	MCT4	NNP
cord-295807-68sukdb1	746	38	and	and	CC
cord-295807-68sukdb1	746	39	CAIX	CAIX	NNP
cord-295807-68sukdb1	746	40	.	.	.
cord-295807-68sukdb1	747	1	Other	other	JJ
cord-295807-68sukdb1	747	2	approached	approach	VBN
cord-295807-68sukdb1	747	3	include	include	VBP
cord-295807-68sukdb1	747	4	exploiting	exploit	VBG
cord-295807-68sukdb1	747	5	the	the	DT
cord-295807-68sukdb1	747	6	acidic	acidic	JJ
cord-295807-68sukdb1	747	7	milieu	milieu	NN
cord-295807-68sukdb1	747	8	of	of	IN
cord-295807-68sukdb1	747	9	the	the	DT
cord-295807-68sukdb1	747	10	tumor	tumor	NN
cord-295807-68sukdb1	747	11	for	for	IN
cord-295807-68sukdb1	747	12	the	the	DT
cord-295807-68sukdb1	747	13	targeted	target	VBN
cord-295807-68sukdb1	747	14	delivery	delivery	NN
cord-295807-68sukdb1	747	15	of	of	IN
cord-295807-68sukdb1	747	16	chemotherapeutic	chemotherapeutic	JJ
cord-295807-68sukdb1	747	17	drugs	drug	NNS
cord-295807-68sukdb1	747	18	(	(	-LRB-
cord-295807-68sukdb1	747	19	see	see	VB
cord-295807-68sukdb1	747	20	section	section	NN
cord-295807-68sukdb1	747	21	6.6	6.6	CD
cord-295807-68sukdb1	747	22	)	)	-RRB-
cord-295807-68sukdb1	747	23	.	.	.
cord-295807-68sukdb1	748	1	Figure	figure	NN
cord-295807-68sukdb1	748	2	12	12	CD
cord-295807-68sukdb1	748	3	.	.	.
cord-295807-68sukdb1	749	1	The	the	DT
cord-295807-68sukdb1	749	2	influence	influence	NN
cord-295807-68sukdb1	749	3	of	of	IN
cord-295807-68sukdb1	749	4	pH	ph	NN
cord-295807-68sukdb1	749	5	on	on	IN
cord-295807-68sukdb1	749	6	drug	drug	NN
cord-295807-68sukdb1	749	7	distribution	distribution	NN
cord-295807-68sukdb1	749	8	.	.	.
cord-295807-68sukdb1	750	1	Theoretical	theoretical	JJ
cord-295807-68sukdb1	750	2	distribution	distribution	NN
cord-295807-68sukdb1	750	3	of	of	IN
cord-295807-68sukdb1	750	4	a	a	DT
cord-295807-68sukdb1	750	5	hypothetical	hypothetical	JJ
cord-295807-68sukdb1	750	6	weakly	weakly	RB
cord-295807-68sukdb1	750	7	acidic	acidic	JJ
cord-295807-68sukdb1	750	8	drug	drug	NN
cord-295807-68sukdb1	750	9	(	(	-LRB-
cord-295807-68sukdb1	750	10	pKa	pKa	NNP
cord-295807-68sukdb1	750	11	=	=	SYM
cord-295807-68sukdb1	750	12	3.4	3.4	CD
cord-295807-68sukdb1	750	13	,	,	,
cord-295807-68sukdb1	750	14	panel	panel	NN
cord-295807-68sukdb1	750	15	'	'	``
cord-295807-68sukdb1	750	16	A	a	NN
cord-295807-68sukdb1	750	17	'	'	''
cord-295807-68sukdb1	750	18	)	)	-RRB-
cord-295807-68sukdb1	750	19	and	and	CC
cord-295807-68sukdb1	750	20	a	a	DT
cord-295807-68sukdb1	750	21	hypothetical	hypothetical	JJ
cord-295807-68sukdb1	750	22	weakly	weakly	RB
cord-295807-68sukdb1	750	23	basic	basic	JJ
cord-295807-68sukdb1	750	24	drug	drug	NN
cord-295807-68sukdb1	750	25	(	(	-LRB-
cord-295807-68sukdb1	750	26	pKa	pKa	NNP
cord-295807-68sukdb1	750	27	=	=	SYM
cord-295807-68sukdb1	750	28	8.4	8.4	CD
cord-295807-68sukdb1	750	29	,	,	,
cord-295807-68sukdb1	750	30	panel	panel	NN
cord-295807-68sukdb1	750	31	'	'	``
cord-295807-68sukdb1	750	32	B	b	NN
cord-295807-68sukdb1	750	33	'	'	''
cord-295807-68sukdb1	750	34	)	)	-RRB-
cord-295807-68sukdb1	750	35	between	between	IN
cord-295807-68sukdb1	750	36	two	two	CD
cord-295807-68sukdb1	750	37	aqueous	aqueous	JJ
cord-295807-68sukdb1	750	38	compartments	compartment	NNS
cord-295807-68sukdb1	750	39	with	with	IN
cord-295807-68sukdb1	750	40	different	different	JJ
cord-295807-68sukdb1	750	41	pH	ph	NN
cord-295807-68sukdb1	750	42	(	(	-LRB-
cord-295807-68sukdb1	750	43	GI	GI	NNP
cord-295807-68sukdb1	750	44	tract	tract	NN
cord-295807-68sukdb1	750	45	at	at	IN
cord-295807-68sukdb1	750	46	pH	ph	NN
cord-295807-68sukdb1	750	47	=	=	NNP
cord-295807-68sukdb1	750	48	1.4	1.4	CD
cord-295807-68sukdb1	750	49	and	and	CC
cord-295807-68sukdb1	750	50	blood	blood	NN
cord-295807-68sukdb1	750	51	at	at	IN
cord-295807-68sukdb1	750	52	pH	ph	NN
cord-295807-68sukdb1	750	53	=	=	NNP
cord-295807-68sukdb1	750	54	7.4	7.4	CD
cord-295807-68sukdb1	750	55	)	)	-RRB-
cord-295807-68sukdb1	750	56	.	.	.
cord-295807-68sukdb1	751	1	Assuming	assume	VBG
cord-295807-68sukdb1	751	2	that	that	IN
cord-295807-68sukdb1	751	3	only	only	RB
cord-295807-68sukdb1	751	4	the	the	DT
cord-295807-68sukdb1	751	5	unionized	unionized	JJ
cord-295807-68sukdb1	751	6	form	form	NN
cord-295807-68sukdb1	751	7	U	u	NN
cord-295807-68sukdb1	751	8	(	(	-LRB-
cord-295807-68sukdb1	751	9	HA	HA	NNP
cord-295807-68sukdb1	751	10	in	in	IN
cord-295807-68sukdb1	751	11	panel	panel	NN
cord-295807-68sukdb1	751	12	'	'	``
cord-295807-68sukdb1	751	13	A	A	NNP
cord-295807-68sukdb1	751	14	'	'	''
cord-295807-68sukdb1	751	15	and	and	CC
cord-295807-68sukdb1	751	16	B	b	NN
cord-295807-68sukdb1	751	17	in	in	IN
cord-295807-68sukdb1	751	18	panel	panel	NN
cord-295807-68sukdb1	751	19	'	'	``
cord-295807-68sukdb1	751	20	B	b	NN
cord-295807-68sukdb1	751	21	'	'	''
cord-295807-68sukdb1	751	22	)	)	-RRB-
cord-295807-68sukdb1	751	23	can	can	MD
cord-295807-68sukdb1	751	24	cross	cross	VB
cord-295807-68sukdb1	751	25	the	the	DT
cord-295807-68sukdb1	751	26	membrane	membrane	NN
cord-295807-68sukdb1	751	27	and	and	CC
cord-295807-68sukdb1	751	28	that	that	IN
cord-295807-68sukdb1	751	29	U	U	NNP
cord-295807-68sukdb1	751	30	is	be	VBZ
cord-295807-68sukdb1	751	31	equilibrated	equilibrate	VBN
cord-295807-68sukdb1	751	32	across	across	IN
cord-295807-68sukdb1	751	33	the	the	DT
cord-295807-68sukdb1	751	34	plasma	plasma	NN
cord-295807-68sukdb1	751	35	membrane	membrane	NN
cord-295807-68sukdb1	751	36	,	,	,
cord-295807-68sukdb1	751	37	panel	panel	NN
cord-295807-68sukdb1	751	38	'	'	``
cord-295807-68sukdb1	751	39	A	a	NN
cord-295807-68sukdb1	751	40	'	'	''
cord-295807-68sukdb1	751	41	shows	show	VBZ
cord-295807-68sukdb1	751	42	that	that	IN
cord-295807-68sukdb1	751	43	a	a	DT
cord-295807-68sukdb1	751	44	weakly	weakly	RB
cord-295807-68sukdb1	751	45	acidic	acidic	JJ
cord-295807-68sukdb1	751	46	drug	drug	NN
cord-295807-68sukdb1	751	47	is	be	VBZ
cord-295807-68sukdb1	751	48	more	more	RBR
cord-295807-68sukdb1	751	49	concentrated	concentrated	JJ
cord-295807-68sukdb1	751	50	in	in	IN
cord-295807-68sukdb1	751	51	the	the	DT
cord-295807-68sukdb1	751	52	alkaline	alkaline	JJ
cord-295807-68sukdb1	751	53	compartment	compartment	NN
cord-295807-68sukdb1	751	54	.	.	.
cord-295807-68sukdb1	752	1	This	this	DT
cord-295807-68sukdb1	752	2	result	result	NN
cord-295807-68sukdb1	752	3	suggests	suggest	VBZ
cord-295807-68sukdb1	752	4	that	that	IN
cord-295807-68sukdb1	752	5	weakly	weakly	RB
cord-295807-68sukdb1	752	6	acidic	acidic	JJ
cord-295807-68sukdb1	752	7	drugs	drug	NNS
cord-295807-68sukdb1	752	8	tend	tend	VBP
cord-295807-68sukdb1	752	9	to	to	TO
cord-295807-68sukdb1	752	10	be	be	VB
cord-295807-68sukdb1	752	11	absorbed	absorb	VBN
cord-295807-68sukdb1	752	12	from	from	IN
cord-295807-68sukdb1	752	13	the	the	DT
cord-295807-68sukdb1	752	14	more	more	RBR
cord-295807-68sukdb1	752	15	acidic	acidic	JJ
cord-295807-68sukdb1	752	16	compartment	compartment	NN
cord-295807-68sukdb1	752	17	to	to	IN
cord-295807-68sukdb1	752	18	the	the	DT
cord-295807-68sukdb1	752	19	more	more	RBR
cord-295807-68sukdb1	752	20	basic	basic	JJ
cord-295807-68sukdb1	752	21	compartment	compartment	NN
cord-295807-68sukdb1	752	22	(	(	-LRB-
cord-295807-68sukdb1	752	23	blue	blue	JJ
cord-295807-68sukdb1	752	24	arrows	arrow	NNS
cord-295807-68sukdb1	752	25	)	)	-RRB-
cord-295807-68sukdb1	752	26	.	.	.
cord-295807-68sukdb1	753	1	Panel	panel	NN
cord-295807-68sukdb1	753	2	'	'	``
cord-295807-68sukdb1	753	3	B	b	NN
cord-295807-68sukdb1	753	4	'	'	''
cord-295807-68sukdb1	753	5	shows	show	VBZ
cord-295807-68sukdb1	753	6	that	that	IN
cord-295807-68sukdb1	753	7	a	a	DT
cord-295807-68sukdb1	753	8	weakly	weakly	RB
cord-295807-68sukdb1	753	9	basic	basic	JJ
cord-295807-68sukdb1	753	10	drug	drug	NN
cord-295807-68sukdb1	753	11	is	be	VBZ
cord-295807-68sukdb1	753	12	more	more	RBR
cord-295807-68sukdb1	753	13	concentrated	concentrated	JJ
cord-295807-68sukdb1	753	14	in	in	IN
cord-295807-68sukdb1	753	15	the	the	DT
cord-295807-68sukdb1	753	16	acidic	acidic	JJ
cord-295807-68sukdb1	753	17	compartment	compartment	NN
cord-295807-68sukdb1	753	18	,	,	,
cord-295807-68sukdb1	753	19	indicating	indicate	VBG
cord-295807-68sukdb1	753	20	that	that	IN
cord-295807-68sukdb1	753	21	weakly	weakly	RB
cord-295807-68sukdb1	753	22	basic	basic	JJ
cord-295807-68sukdb1	753	23	drugs	drug	NNS
cord-295807-68sukdb1	753	24	are	be	VBP
cord-295807-68sukdb1	753	25	poorly	poorly	RB
cord-295807-68sukdb1	753	26	absorbed	absorb	VBN
cord-295807-68sukdb1	753	27	in	in	IN
cord-295807-68sukdb1	753	28	an	an	DT
cord-295807-68sukdb1	753	29	acidic	acidic	JJ
cord-295807-68sukdb1	753	30	compartment	compartment	NN
cord-295807-68sukdb1	753	31	(	(	-LRB-
cord-295807-68sukdb1	753	32	blue	blue	JJ
cord-295807-68sukdb1	753	33	arrows	arrow	NNS
cord-295807-68sukdb1	753	34	)	)	-RRB-
cord-295807-68sukdb1	753	35	.	.	.
cord-295807-68sukdb1	754	1	Weakly	weakly	RB
cord-295807-68sukdb1	754	2	basic	basic	JJ
cord-295807-68sukdb1	754	3	drugs	drug	NNS
cord-295807-68sukdb1	754	4	are	be	VBP
cord-295807-68sukdb1	754	5	in	in	IN
cord-295807-68sukdb1	754	6	fact	fact	NN
cord-295807-68sukdb1	754	7	poorly	poorly	RB
cord-295807-68sukdb1	754	8	absorbed	absorb	VBN
cord-295807-68sukdb1	754	9	from	from	IN
cord-295807-68sukdb1	754	10	the	the	DT
cord-295807-68sukdb1	754	11	stomach	stomach	NN
cord-295807-68sukdb1	754	12	.	.	.
cord-295807-68sukdb1	755	1	[	[	-LRB-
cord-295807-68sukdb1	755	2	 	 	_SP
cord-295807-68sukdb1	755	3	The	the	DT
cord-295807-68sukdb1	755	4	history	history	NN
cord-295807-68sukdb1	755	5	of	of	IN
cord-295807-68sukdb1	755	6	blood	blood	NN
cord-295807-68sukdb1	755	7	gases	gas	NNS
cord-295807-68sukdb1	755	8	,	,	,
cord-295807-68sukdb1	755	9	acids	acid	NNS
cord-295807-68sukdb1	755	10	and	and	CC
cord-295807-68sukdb1	755	11	bases	basis	NNS
cord-295807-68sukdb1	755	12	Dietary	dietary	JJ
cord-295807-68sukdb1	755	13	Acid	Acid	NNP
cord-295807-68sukdb1	755	14	,	,	,
cord-295807-68sukdb1	755	15	Age	Age	NNP
cord-295807-68sukdb1	755	16	,	,	,
cord-295807-68sukdb1	755	17	and	and	CC
cord-295807-68sukdb1	755	18	Serum	serum	NN
cord-295807-68sukdb1	755	19	Bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	755	20	Levels	level	NNS
cord-295807-68sukdb1	755	21	among	among	IN
cord-295807-68sukdb1	755	22	Adults	Adults	NNPS
cord-295807-68sukdb1	755	23	in	in	IN
cord-295807-68sukdb1	755	24	the	the	DT
cord-295807-68sukdb1	755	25	United	United	NNP
cord-295807-68sukdb1	755	26	States	States	NNP
cord-295807-68sukdb1	755	27	Higher	Higher	NNP
cord-295807-68sukdb1	755	28	estimates	estimate	NNS
cord-295807-68sukdb1	755	29	of	of	IN
cord-295807-68sukdb1	755	30	daily	daily	JJ
cord-295807-68sukdb1	755	31	dietary	dietary	JJ
cord-295807-68sukdb1	755	32	net	net	JJ
cord-295807-68sukdb1	755	33	endogenous	endogenous	JJ
cord-295807-68sukdb1	755	34	acid	acid	NN
cord-295807-68sukdb1	755	35	production	production	NN
cord-295807-68sukdb1	755	36	(	(	-LRB-
cord-295807-68sukdb1	755	37	NEAP	NEAP	NNP
cord-295807-68sukdb1	755	38	)	)	-RRB-
cord-295807-68sukdb1	755	39	in	in	IN
cord-295807-68sukdb1	755	40	the	the	DT
cord-295807-68sukdb1	755	41	elderly	elderly	JJ
cord-295807-68sukdb1	755	42	as	as	IN
cord-295807-68sukdb1	755	43	compared	compare	VBN
cord-295807-68sukdb1	755	44	to	to	IN
cord-295807-68sukdb1	755	45	the	the	DT
cord-295807-68sukdb1	755	46	young	young	JJ
cord-295807-68sukdb1	755	47	in	in	IN
cord-295807-68sukdb1	755	48	a	a	DT
cord-295807-68sukdb1	755	49	healthy	healthy	JJ
cord-295807-68sukdb1	755	50	,	,	,
cord-295807-68sukdb1	755	51	free	free	JJ
cord-295807-68sukdb1	755	52	-	-	HYPH
cord-295807-68sukdb1	755	53	living	live	VBG
cord-295807-68sukdb1	755	54	elderly	elderly	JJ
cord-295807-68sukdb1	755	55	population	population	NN
cord-295807-68sukdb1	755	56	of	of	IN
cord-295807-68sukdb1	755	57	Pakistan	Pakistan	NNP
cord-295807-68sukdb1	755	58	Cellular	Cellular	NNP
cord-295807-68sukdb1	755	59	mechanisms	mechanism	NNS
cord-295807-68sukdb1	755	60	involved	involve	VBN
cord-295807-68sukdb1	755	61	in	in	IN
cord-295807-68sukdb1	755	62	CO(2	CO(2	NNP
cord-295807-68sukdb1	755	63	)	)	-RRB-
cord-295807-68sukdb1	755	64	and	and	CC
cord-295807-68sukdb1	755	65	acid	acid	NN
cord-295807-68sukdb1	755	66	signaling	signal	VBG
cord-295807-68sukdb1	755	67	in	in	IN
cord-295807-68sukdb1	755	68	chemosensitive	chemosensitive	JJ
cord-295807-68sukdb1	755	69	neurons	neuron	NNS
cord-295807-68sukdb1	756	1	Mathematical	mathematical	JJ
cord-295807-68sukdb1	756	2	modeling	modeling	NN
cord-295807-68sukdb1	756	3	of	of	IN
cord-295807-68sukdb1	756	4	acid	acid	NN
cord-295807-68sukdb1	756	5	-	-	HYPH
cord-295807-68sukdb1	756	6	base	base	NN
cord-295807-68sukdb1	756	7	physiology	physiology	NN
cord-295807-68sukdb1	756	8	Acid	Acid	NNP
cord-295807-68sukdb1	756	9	Base	Base	NNP
cord-295807-68sukdb1	756	10	Physiology	Physiology	NNP
cord-295807-68sukdb1	756	11	Racial	Racial	NNP
cord-295807-68sukdb1	756	12	/	/	SYM
cord-295807-68sukdb1	756	13	Ethnic	ethnic	JJ
cord-295807-68sukdb1	756	14	-	-	HYPH
cord-295807-68sukdb1	756	15	Specific	specific	JJ
cord-295807-68sukdb1	756	16	Reference	reference	NN
cord-295807-68sukdb1	756	17	Intervals	Intervals	NNP
cord-295807-68sukdb1	756	18	for	for	IN
cord-295807-68sukdb1	756	19	Common	Common	NNP
cord-295807-68sukdb1	756	20	Laboratory	Laboratory	NNP
cord-295807-68sukdb1	756	21	Tests	Tests	NNPS
cord-295807-68sukdb1	756	22	:	:	:
cord-295807-68sukdb1	757	1	A	a	DT
cord-295807-68sukdb1	757	2	Comparison	comparison	NN
cord-295807-68sukdb1	757	3	among	among	IN
cord-295807-68sukdb1	757	4	Asians	Asians	NNPS
cord-295807-68sukdb1	757	5	,	,	,
cord-295807-68sukdb1	757	6	Blacks	black	NNS
cord-295807-68sukdb1	757	7	,	,	,
cord-295807-68sukdb1	757	8	Hispanics	Hispanics	NNPS
cord-295807-68sukdb1	757	9	,	,	,
cord-295807-68sukdb1	757	10	and	and	CC
cord-295807-68sukdb1	757	11	White	White	NNP
cord-295807-68sukdb1	757	12	Centers	Centers	NNPS
cord-295807-68sukdb1	757	13	for	for	IN
cord-295807-68sukdb1	757	14	Disease	Disease	NNP
cord-295807-68sukdb1	757	15	Control	Control	NNP
cord-295807-68sukdb1	757	16	and	and	CC
cord-295807-68sukdb1	757	17	Prevention	Prevention	NNP
cord-295807-68sukdb1	757	18	Chronic	Chronic	NNP
cord-295807-68sukdb1	757	19	Kidney	Kidney	NNP
cord-295807-68sukdb1	757	20	Disease	Disease	NNP
cord-295807-68sukdb1	757	21	Surveillance	Surveillance	NNP
cord-295807-68sukdb1	757	22	Team	Team	NNP
cord-295807-68sukdb1	757	23	,	,	,
cord-295807-68sukdb1	757	24	Race	Race	NNP
cord-295807-68sukdb1	757	25	/	/	SYM
cord-295807-68sukdb1	757	26	Ethnicity	Ethnicity	NNP
cord-295807-68sukdb1	757	27	,	,	,
cord-295807-68sukdb1	757	28	Dietary	Dietary	NNP
cord-295807-68sukdb1	757	29	Acid	Acid	NNP
cord-295807-68sukdb1	757	30	Load	Load	NNP
cord-295807-68sukdb1	757	31	,	,	,
cord-295807-68sukdb1	757	32	and	and	CC
cord-295807-68sukdb1	757	33	Risk	risk	NN
cord-295807-68sukdb1	757	34	of	of	IN
cord-295807-68sukdb1	757	35	End	end	NN
cord-295807-68sukdb1	757	36	-	-	HYPH
cord-295807-68sukdb1	757	37	Stage	stage	NN
cord-295807-68sukdb1	757	38	Renal	Renal	NNP
cord-295807-68sukdb1	757	39	Disease	Disease	NNP
cord-295807-68sukdb1	757	40	among	among	IN
cord-295807-68sukdb1	757	41	US	US	NNP
cord-295807-68sukdb1	757	42	Adults	Adults	NNPS
cord-295807-68sukdb1	757	43	with	with	IN
cord-295807-68sukdb1	757	44	Chronic	Chronic	NNP
cord-295807-68sukdb1	757	45	Kidney	Kidney	NNP
cord-295807-68sukdb1	757	46	Disease	Disease	NNP
cord-295807-68sukdb1	757	47	NHANES	NHANES	NNP
cord-295807-68sukdb1	757	48	III	III	NNP
cord-295807-68sukdb1	757	49	:	:	:
cord-295807-68sukdb1	757	50	Influence	influence	NN
cord-295807-68sukdb1	757	51	of	of	IN
cord-295807-68sukdb1	757	52	Race	race	NN
cord-295807-68sukdb1	757	53	on	on	IN
cord-295807-68sukdb1	757	54	GFR	GFR	NNP
cord-295807-68sukdb1	757	55	Thresholds	Thresholds	NNP
cord-295807-68sukdb1	757	56	and	and	CC
cord-295807-68sukdb1	757	57	Detection	Detection	NNP
cord-295807-68sukdb1	757	58	of	of	IN
cord-295807-68sukdb1	757	59	Metabolic	metabolic	JJ
cord-295807-68sukdb1	757	60	Abnormalities	abnormality	NNS
cord-295807-68sukdb1	757	61	Ethnicity	ethnicity	NN
cord-295807-68sukdb1	757	62	and	and	CC
cord-295807-68sukdb1	757	63	young	young	JJ
cord-295807-68sukdb1	757	64	age	age	NN
cord-295807-68sukdb1	757	65	influence	influence	VBP
cord-295807-68sukdb1	757	66	the	the	DT
cord-295807-68sukdb1	757	67	frequency	frequency	NN
cord-295807-68sukdb1	757	68	of	of	IN
cord-295807-68sukdb1	757	69	diabetic	diabetic	JJ
cord-295807-68sukdb1	757	70	ketoacidosis	ketoacidosis	NN
cord-295807-68sukdb1	757	71	at	at	IN
cord-295807-68sukdb1	757	72	the	the	DT
cord-295807-68sukdb1	757	73	onset	onset	NN
cord-295807-68sukdb1	757	74	of	of	IN
cord-295807-68sukdb1	757	75	type	type	NN
cord-295807-68sukdb1	757	76	1	1	CD
cord-295807-68sukdb1	757	77	diabetes	diabete	VBZ
cord-295807-68sukdb1	757	78	Admissions	admission	NNS
cord-295807-68sukdb1	757	79	for	for	IN
cord-295807-68sukdb1	757	80	diabetic	diabetic	JJ
cord-295807-68sukdb1	757	81	ketoacidosis	ketoacidosis	NN
cord-295807-68sukdb1	757	82	in	in	IN
cord-295807-68sukdb1	757	83	ethnic	ethnic	JJ
cord-295807-68sukdb1	757	84	minority	minority	NN
cord-295807-68sukdb1	757	85	groups	group	NNS
cord-295807-68sukdb1	757	86	in	in	IN
cord-295807-68sukdb1	757	87	a	a	DT
cord-295807-68sukdb1	757	88	city	city	NN
cord-295807-68sukdb1	757	89	hospital	hospital	NN
cord-295807-68sukdb1	757	90	Differences	difference	NNS
cord-295807-68sukdb1	757	91	in	in	IN
cord-295807-68sukdb1	757	92	acidosisstimulated	acidosisstimulate	VBN
cord-295807-68sukdb1	757	93	renal	renal	JJ
cord-295807-68sukdb1	757	94	ammonia	ammonia	NN
cord-295807-68sukdb1	757	95	metabolism	metabolism	NN
cord-295807-68sukdb1	757	96	in	in	IN
cord-295807-68sukdb1	757	97	the	the	DT
cord-295807-68sukdb1	757	98	male	male	JJ
cord-295807-68sukdb1	757	99	and	and	CC
cord-295807-68sukdb1	757	100	female	female	JJ
cord-295807-68sukdb1	757	101	kidney	kidney	NN
cord-295807-68sukdb1	757	102	Effect	effect	NN
cord-295807-68sukdb1	757	103	of	of	IN
cord-295807-68sukdb1	757	104	age	age	NN
cord-295807-68sukdb1	757	105	on	on	IN
cord-295807-68sukdb1	757	106	blood	blood	NN
cord-295807-68sukdb1	757	107	acid	acid	NN
cord-295807-68sukdb1	757	108	-	-	HYPH
cord-295807-68sukdb1	757	109	base	base	NN
cord-295807-68sukdb1	757	110	composition	composition	NN
cord-295807-68sukdb1	757	111	in	in	IN
cord-295807-68sukdb1	757	112	adult	adult	NN
cord-295807-68sukdb1	757	113	humans	human	NNS
cord-295807-68sukdb1	757	114	:	:	:
cord-295807-68sukdb1	757	115	role	role	NN
cord-295807-68sukdb1	757	116	of	of	IN
cord-295807-68sukdb1	757	117	age	age	NN
cord-295807-68sukdb1	757	118	-	-	HYPH
cord-295807-68sukdb1	757	119	related	relate	VBN
cord-295807-68sukdb1	757	120	renal	renal	JJ
cord-295807-68sukdb1	757	121	functional	functional	JJ
cord-295807-68sukdb1	757	122	decline	decline	NN
cord-295807-68sukdb1	757	123	Chapter	Chapter	NNP
cord-295807-68sukdb1	757	124	2	2	CD
cord-295807-68sukdb1	758	1	-Human	-Human	.
cord-295807-68sukdb1	759	1	Carbonic	carbonic	JJ
cord-295807-68sukdb1	759	2	Anhydrases	anhydrase	NNS
cord-295807-68sukdb1	759	3	:	:	:
cord-295807-68sukdb1	760	1	Catalytic	Catalytic	NNP
cord-295807-68sukdb1	760	2	Properties	Properties	NNPS
cord-295807-68sukdb1	760	3	Role	role	NN
cord-295807-68sukdb1	760	4	of	of	IN
cord-295807-68sukdb1	760	5	Carbonic	Carbonic	NNP
cord-295807-68sukdb1	760	6	Anhydrases	Anhydrases	NNP
cord-295807-68sukdb1	760	7	and	and	CC
cord-295807-68sukdb1	760	8	Inhibitors	Inhibitors	NNPS
cord-295807-68sukdb1	760	9	in	in	IN
cord-295807-68sukdb1	760	10	Acid	Acid	NNP
cord-295807-68sukdb1	760	11	-	-	HYPH
cord-295807-68sukdb1	760	12	Base	Base	NNP
cord-295807-68sukdb1	760	13	Physiology	physiology	NN
cord-295807-68sukdb1	760	14	:	:	:
cord-295807-68sukdb1	761	1	Insights	insight	NNS
cord-295807-68sukdb1	761	2	from	from	IN
cord-295807-68sukdb1	761	3	Mathematical	Mathematical	NNP
cord-295807-68sukdb1	761	4	Modeling	Modeling	NNP
cord-295807-68sukdb1	761	5	StatPearls	StatPearls	NNP
cord-295807-68sukdb1	761	6	,	,	,
cord-295807-68sukdb1	761	7	StatPearls	StatPearls	NNP
cord-295807-68sukdb1	761	8	Publishing	Publishing	NNP
cord-295807-68sukdb1	761	9	,	,	,
cord-295807-68sukdb1	761	10	Treasure	Treasure	NNP
cord-295807-68sukdb1	761	11	Island	Island	NNP
cord-295807-68sukdb1	761	12	(	(	-LRB-
cord-295807-68sukdb1	761	13	FL	FL	NNP
cord-295807-68sukdb1	761	14	)	)	-RRB-
cord-295807-68sukdb1	761	15	,	,	,
cord-295807-68sukdb1	761	16	2020	2020	CD
cord-295807-68sukdb1	761	17	Clinical	clinical	JJ
cord-295807-68sukdb1	761	18	physiology	physiology	NN
cord-295807-68sukdb1	761	19	of	of	IN
cord-295807-68sukdb1	761	20	acid	acid	NN
cord-295807-68sukdb1	761	21	-	-	HYPH
cord-295807-68sukdb1	761	22	base	base	NN
cord-295807-68sukdb1	761	23	and	and	CC
cord-295807-68sukdb1	761	24	electrolyte	electrolyte	NN
cord-295807-68sukdb1	761	25	disorders	disorder	NNS
cord-295807-68sukdb1	761	26	Metabolic	metabolic	VBP
cord-295807-68sukdb1	761	27	Acidosis	acidosis	NN
cord-295807-68sukdb1	761	28	in	in	IN
cord-295807-68sukdb1	761	29	CKD	CKD	NNP
cord-295807-68sukdb1	761	30	:	:	:
cord-295807-68sukdb1	762	1	Core	core	NN
cord-295807-68sukdb1	762	2	Curriculum	Curriculum	NNP
cord-295807-68sukdb1	762	3	Renal	Renal	NNP
cord-295807-68sukdb1	762	4	Pathophysiology	pathophysiology	NN
cord-295807-68sukdb1	762	5	:	:	:
cord-295807-68sukdb1	763	1	The	the	DT
cord-295807-68sukdb1	763	2	Essentials	Essentials	NNPS
cord-295807-68sukdb1	763	3	Renal	Renal	NNP
cord-295807-68sukdb1	763	4	tubular	tubular	JJ
cord-295807-68sukdb1	763	5	acidosis	acidosis	NN
cord-295807-68sukdb1	763	6	:	:	:
cord-295807-68sukdb1	763	7	developments	development	NNS
cord-295807-68sukdb1	763	8	in	in	IN
cord-295807-68sukdb1	763	9	our	-PRON-	PRP$
cord-295807-68sukdb1	763	10	understanding	understanding	NN
cord-295807-68sukdb1	763	11	of	of	IN
cord-295807-68sukdb1	763	12	the	the	DT
cord-295807-68sukdb1	763	13	molecular	molecular	JJ
cord-295807-68sukdb1	763	14	basis	basis	NN
cord-295807-68sukdb1	764	1	Drug	drug	NN
cord-295807-68sukdb1	764	2	-	-	HYPH
cord-295807-68sukdb1	764	3	Induced	induce	VBN
cord-295807-68sukdb1	764	4	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	764	5	Acidosis	acidosis	NN
cord-295807-68sukdb1	764	6	,	,	,
cord-295807-68sukdb1	764	7	F1000Res	F1000Res	NNP
cord-295807-68sukdb1	764	8	Metabolic	metabolic	JJ
cord-295807-68sukdb1	764	9	acidosis	acidosis	NN
cord-295807-68sukdb1	764	10	:	:	:
cord-295807-68sukdb1	764	11	pathophysiology	pathophysiology	NN
cord-295807-68sukdb1	764	12	,	,	,
cord-295807-68sukdb1	764	13	diagnosis	diagnosis	NN
cord-295807-68sukdb1	764	14	and	and	CC
cord-295807-68sukdb1	764	15	management	management	NN
cord-295807-68sukdb1	764	16	Diet	diet	NN
cord-295807-68sukdb1	764	17	-	-	HYPH
cord-295807-68sukdb1	764	18	Induced	Induced	NNP
cord-295807-68sukdb1	764	19	Low	low	JJ
cord-295807-68sukdb1	764	20	-	-	HYPH
cord-295807-68sukdb1	764	21	Grade	grade	NN
cord-295807-68sukdb1	764	22	Metabolic	metabolic	JJ
cord-295807-68sukdb1	764	23	Acidosis	acidosis	NN
cord-295807-68sukdb1	764	24	and	and	CC
cord-295807-68sukdb1	764	25	Clinical	Clinical	NNP
cord-295807-68sukdb1	764	26	Outcomes	outcome	NNS
cord-295807-68sukdb1	764	27	:	:	:
cord-295807-68sukdb1	765	1	A	a	DT
cord-295807-68sukdb1	765	2	Review	Review	NNP
cord-295807-68sukdb1	765	3	Handbook	Handbook	NNP
cord-295807-68sukdb1	765	4	of	of	IN
cord-295807-68sukdb1	765	5	Pathophysiology	Pathophysiology	NNP
cord-295807-68sukdb1	766	1	The	the	DT
cord-295807-68sukdb1	766	2	alkaline	alkaline	JJ
cord-295807-68sukdb1	766	3	tide	tide	NN
cord-295807-68sukdb1	766	4	phenomenon	phenomenon	NN
cord-295807-68sukdb1	766	5	Tribonat	Tribonat	NNP
cord-295807-68sukdb1	766	6	--	--	:
cord-295807-68sukdb1	766	7	a	a	DT
cord-295807-68sukdb1	766	8	comprehensive	comprehensive	JJ
cord-295807-68sukdb1	766	9	summary	summary	NN
cord-295807-68sukdb1	766	10	of	of	IN
cord-295807-68sukdb1	766	11	its	-PRON-	PRP$
cord-295807-68sukdb1	766	12	properties	property	NNS
cord-295807-68sukdb1	766	13	Bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	766	14	therapy	therapy	NN
cord-295807-68sukdb1	766	15	and	and	CC
cord-295807-68sukdb1	766	16	intracellular	intracellular	JJ
cord-295807-68sukdb1	766	17	acidosis	acidosis	NN
cord-295807-68sukdb1	766	18	Short	short	JJ
cord-295807-68sukdb1	766	19	-	-	HYPH
cord-295807-68sukdb1	766	20	and	and	CC
cord-295807-68sukdb1	766	21	Long	Long	NNP
cord-295807-68sukdb1	766	22	-	-	HYPH
cord-295807-68sukdb1	766	23	Term	term	NN
cord-295807-68sukdb1	766	24	Effects	effect	NNS
cord-295807-68sukdb1	766	25	of	of	IN
cord-295807-68sukdb1	766	26	Alkali	Alkali	NNP
cord-295807-68sukdb1	766	27	Therapy	Therapy	NNP
cord-295807-68sukdb1	766	28	in	in	IN
cord-295807-68sukdb1	766	29	Chronic	Chronic	NNP
cord-295807-68sukdb1	766	30	Kidney	Kidney	NNP
cord-295807-68sukdb1	766	31	Disease	Disease	NNP
cord-295807-68sukdb1	766	32	:	:	:
cord-295807-68sukdb1	766	33	A	a	DT
cord-295807-68sukdb1	766	34	Systematic	Systematic	NNP
cord-295807-68sukdb1	766	35	Review	Review	NNP
cord-295807-68sukdb1	766	36	Treatment	Treatment	NNP
cord-295807-68sukdb1	766	37	of	of	IN
cord-295807-68sukdb1	766	38	Acidified	acidified	JJ
cord-295807-68sukdb1	766	39	Blood	blood	NN
cord-295807-68sukdb1	766	40	Using	use	VBG
cord-295807-68sukdb1	766	41	Reduced	reduce	VBN
cord-295807-68sukdb1	766	42	Osmolarity	Osmolarity	NNP
cord-295807-68sukdb1	766	43	Mixed	Mixed	NNP
cord-295807-68sukdb1	766	44	-	-	HYPH
cord-295807-68sukdb1	766	45	Base	Base	NNP
cord-295807-68sukdb1	766	46	Solutions	Solutions	NNPS
cord-295807-68sukdb1	766	47	Brain	Brain	NNP
cord-295807-68sukdb1	766	48	pH	pH	NNP
cord-295807-68sukdb1	766	49	effects	effect	NNS
cord-295807-68sukdb1	766	50	of	of	IN
cord-295807-68sukdb1	766	51	NaHCO3	nahco3	NN
cord-295807-68sukdb1	766	52	and	and	CC
cord-295807-68sukdb1	766	53	Carbicarb	Carbicarb	NNP
cord-295807-68sukdb1	766	54	in	in	IN
cord-295807-68sukdb1	766	55	lactic	lactic	JJ
cord-295807-68sukdb1	766	56	acidosis	acidosis	NN
cord-295807-68sukdb1	766	57	Carbicarb	Carbicarb	NNP
cord-295807-68sukdb1	766	58	:	:	:
cord-295807-68sukdb1	766	59	an	an	DT
cord-295807-68sukdb1	766	60	effective	effective	JJ
cord-295807-68sukdb1	766	61	substitute	substitute	NN
cord-295807-68sukdb1	766	62	for	for	IN
cord-295807-68sukdb1	766	63	NaHCO3	NaHCO3	NNP
cord-295807-68sukdb1	766	64	for	for	IN
cord-295807-68sukdb1	766	65	the	the	DT
cord-295807-68sukdb1	766	66	treatment	treatment	NN
cord-295807-68sukdb1	766	67	of	of	IN
cord-295807-68sukdb1	766	68	acidosis	acidosis	NN
cord-295807-68sukdb1	767	1	The	the	DT
cord-295807-68sukdb1	767	2	Treatment	Treatment	NNP
cord-295807-68sukdb1	767	3	of	of	IN
cord-295807-68sukdb1	767	4	Acidosis	acidosis	NN
cord-295807-68sukdb1	767	5	in	in	IN
cord-295807-68sukdb1	767	6	Acute	Acute	NNP
cord-295807-68sukdb1	767	7	Lung	Lung	NNP
cord-295807-68sukdb1	767	8	Injury	injury	NN
cord-295807-68sukdb1	767	9	with	with	IN
cord-295807-68sukdb1	767	10	Tris	Tris	NNP
cord-295807-68sukdb1	767	11	-	-	HYPH
cord-295807-68sukdb1	767	12	Hydroxymethyl	Hydroxymethyl	NNP
cord-295807-68sukdb1	767	13	Aminomethane	Aminomethane	NNP
cord-295807-68sukdb1	767	14	(	(	-LRB-
cord-295807-68sukdb1	767	15	THAM	THAM	NNP
cord-295807-68sukdb1	767	16	)	)	-RRB-
cord-295807-68sukdb1	768	1	Sodium	sodium	NN
cord-295807-68sukdb1	768	2	Acetate	Acetate	NNP
cord-295807-68sukdb1	768	3	as	as	IN
cord-295807-68sukdb1	768	4	a	a	DT
cord-295807-68sukdb1	768	5	Replacement	replacement	NN
cord-295807-68sukdb1	768	6	for	for	IN
cord-295807-68sukdb1	768	7	Sodium	Sodium	NNP
cord-295807-68sukdb1	768	8	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	768	9	in	in	IN
cord-295807-68sukdb1	768	10	Medical	Medical	NNP
cord-295807-68sukdb1	768	11	Toxicology	Toxicology	NNP
cord-295807-68sukdb1	768	12	:	:	:
cord-295807-68sukdb1	768	13	a	a	DT
cord-295807-68sukdb1	768	14	Review	Review	NNP
cord-295807-68sukdb1	768	15	Lactate	Lactate	NNP
cord-295807-68sukdb1	768	16	versus	versus	IN
cord-295807-68sukdb1	768	17	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	768	18	.	.	.
cord-295807-68sukdb1	769	1	A	a	DT
cord-295807-68sukdb1	769	2	reconsideration	reconsideration	NN
cord-295807-68sukdb1	769	3	of	of	IN
cord-295807-68sukdb1	769	4	the	the	DT
cord-295807-68sukdb1	769	5	therapy	therapy	NN
cord-295807-68sukdb1	769	6	of	of	IN
cord-295807-68sukdb1	769	7	metabolic	metabolic	JJ
cord-295807-68sukdb1	769	8	acidosis	acidosis	NN
cord-295807-68sukdb1	769	9	Estimated	estimate	VBN
cord-295807-68sukdb1	769	10	net	net	JJ
cord-295807-68sukdb1	769	11	endogenous	endogenous	JJ
cord-295807-68sukdb1	769	12	acid	acid	NN
cord-295807-68sukdb1	769	13	production	production	NN
cord-295807-68sukdb1	769	14	and	and	CC
cord-295807-68sukdb1	769	15	serum	serum	NN
cord-295807-68sukdb1	769	16	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	769	17	in	in	IN
cord-295807-68sukdb1	769	18	African	african	JJ
cord-295807-68sukdb1	769	19	Americans	Americans	NNPS
cord-295807-68sukdb1	769	20	with	with	IN
cord-295807-68sukdb1	769	21	chronic	chronic	JJ
cord-295807-68sukdb1	769	22	kidney	kidney	NN
cord-295807-68sukdb1	769	23	disease	disease	NN
cord-295807-68sukdb1	769	24	Dietary	Dietary	NNP
cord-295807-68sukdb1	769	25	Acid	Acid	NNP
cord-295807-68sukdb1	769	26	Load	Load	NNP
cord-295807-68sukdb1	769	27	is	be	VBZ
cord-295807-68sukdb1	769	28	Associated	Associated	NNP
cord-295807-68sukdb1	769	29	With	with	IN
cord-295807-68sukdb1	769	30	Serum	serum	NN
cord-295807-68sukdb1	769	31	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	769	32	but	but	CC
cord-295807-68sukdb1	769	33	not	not	RB
cord-295807-68sukdb1	769	34	Insulin	Insulin	NNP
cord-295807-68sukdb1	769	35	Sensitivity	sensitivity	NN
cord-295807-68sukdb1	769	36	in	in	IN
cord-295807-68sukdb1	769	37	Chronic	Chronic	NNP
cord-295807-68sukdb1	769	38	Kidney	kidney	NN
cord-295807-68sukdb1	769	39	Disease	Disease	NNP
cord-295807-68sukdb1	770	1	Very	very	RB
cord-295807-68sukdb1	770	2	Low	Low	NNP
cord-295807-68sukdb1	770	3	-	-	HYPH
cord-295807-68sukdb1	770	4	Protein	Protein	NNP
cord-295807-68sukdb1	770	5	Diet	Diet	NNP
cord-295807-68sukdb1	770	6	(	(	-LRB-
cord-295807-68sukdb1	770	7	VLPD	VLPD	NNP
cord-295807-68sukdb1	770	8	)	)	-RRB-
cord-295807-68sukdb1	770	9	Reduces	reduce	VBZ
cord-295807-68sukdb1	770	10	Metabolic	metabolic	JJ
cord-295807-68sukdb1	770	11	Acidosis	acidosis	NN
cord-295807-68sukdb1	770	12	in	in	IN
cord-295807-68sukdb1	770	13	Subjects	subject	NNS
cord-295807-68sukdb1	770	14	with	with	IN
cord-295807-68sukdb1	770	15	Chronic	Chronic	NNP
cord-295807-68sukdb1	770	16	Kidney	Kidney	NNP
cord-295807-68sukdb1	770	17	Disease	Disease	NNP
cord-295807-68sukdb1	770	18	:	:	:
cord-295807-68sukdb1	770	19	The	the	DT
cord-295807-68sukdb1	770	20	"	"	``
cord-295807-68sukdb1	770	21	Nutritional	Nutritional	NNP
cord-295807-68sukdb1	770	22	Light	Light	NNP
cord-295807-68sukdb1	770	23	Signal	Signal	NNP
cord-295807-68sukdb1	770	24	"	"	''
cord-295807-68sukdb1	770	25	of	of	IN
cord-295807-68sukdb1	770	26	the	the	DT
cord-295807-68sukdb1	770	27	Renal	Renal	NNP
cord-295807-68sukdb1	770	28	Acid	Acid	NNP
cord-295807-68sukdb1	770	29	Load	Load	NNP
cord-295807-68sukdb1	770	30	Fruit	Fruit	NNP
cord-295807-68sukdb1	770	31	and	and	CC
cord-295807-68sukdb1	770	32	Vegetable	Vegetable	NNP
cord-295807-68sukdb1	770	33	Treatment	Treatment	NNP
cord-295807-68sukdb1	770	34	of	of	IN
cord-295807-68sukdb1	770	35	Chronic	Chronic	NNP
cord-295807-68sukdb1	770	36	Kidney	Kidney	NNP
cord-295807-68sukdb1	770	37	Disease	Disease	NNP
cord-295807-68sukdb1	770	38	-	-	HYPH
cord-295807-68sukdb1	770	39	Related	relate	VBN
cord-295807-68sukdb1	770	40	Metabolic	metabolic	JJ
cord-295807-68sukdb1	770	41	Acidosis	acidosis	NN
cord-295807-68sukdb1	770	42	Reduces	reduce	VBZ
cord-295807-68sukdb1	770	43	Cardiovascular	cardiovascular	JJ
cord-295807-68sukdb1	770	44	Risk	risk	NN
cord-295807-68sukdb1	770	45	Better	well	RBR
cord-295807-68sukdb1	770	46	than	than	IN
cord-295807-68sukdb1	770	47	Sodium	Sodium	NNP
cord-295807-68sukdb1	770	48	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	770	49	Therapy	Therapy	NNP
cord-295807-68sukdb1	770	50	of	of	IN
cord-295807-68sukdb1	770	51	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	770	52	-	-	HYPH
cord-295807-68sukdb1	770	53	losing	lose	VBG
cord-295807-68sukdb1	770	54	renal	renal	JJ
cord-295807-68sukdb1	770	55	tubular	tubular	JJ
cord-295807-68sukdb1	770	56	acidosis	acidosis	NN
cord-295807-68sukdb1	770	57	Long	long	JJ
cord-295807-68sukdb1	770	58	-	-	HYPH
cord-295807-68sukdb1	770	59	term	term	NN
cord-295807-68sukdb1	770	60	safety	safety	NN
cord-295807-68sukdb1	770	61	and	and	CC
cord-295807-68sukdb1	770	62	efficacy	efficacy	NN
cord-295807-68sukdb1	770	63	of	of	IN
cord-295807-68sukdb1	770	64	veverimer	veverimer	NNP
cord-295807-68sukdb1	770	65	in	in	IN
cord-295807-68sukdb1	770	66	patients	patient	NNS
cord-295807-68sukdb1	770	67	with	with	IN
cord-295807-68sukdb1	770	68	metabolic	metabolic	JJ
cord-295807-68sukdb1	770	69	acidosis	acidosis	NN
cord-295807-68sukdb1	770	70	in	in	IN
cord-295807-68sukdb1	770	71	chronic	chronic	JJ
cord-295807-68sukdb1	770	72	kidney	kidney	NN
cord-295807-68sukdb1	770	73	disease	disease	NN
cord-295807-68sukdb1	770	74	:	:	:
cord-295807-68sukdb1	771	1	a	a	DT
cord-295807-68sukdb1	771	2	multicentre	multicentre	NNP
cord-295807-68sukdb1	771	3	,	,	,
cord-295807-68sukdb1	771	4	randomised	randomised	JJ
cord-295807-68sukdb1	771	5	,	,	,
cord-295807-68sukdb1	771	6	blinded	blinded	JJ
cord-295807-68sukdb1	771	7	,	,	,
cord-295807-68sukdb1	771	8	placebo	placebo	NN
cord-295807-68sukdb1	771	9	-	-	HYPH
cord-295807-68sukdb1	771	10	controlled	control	VBN
cord-295807-68sukdb1	771	11	,	,	,
cord-295807-68sukdb1	771	12	40-week	40-week	JJ
cord-295807-68sukdb1	771	13	extension	extension	NN
cord-295807-68sukdb1	771	14	Veverimer	Veverimer	NNP
cord-295807-68sukdb1	771	15	:	:	:
cord-295807-68sukdb1	771	16	an	an	DT
cord-295807-68sukdb1	771	17	advance	advance	NN
cord-295807-68sukdb1	771	18	in	in	IN
cord-295807-68sukdb1	771	19	base	base	NN
cord-295807-68sukdb1	771	20	therapy	therapy	NN
cord-295807-68sukdb1	771	21	for	for	IN
cord-295807-68sukdb1	771	22	metabolic	metabolic	JJ
cord-295807-68sukdb1	771	23	acidosis	acidosis	NN
cord-295807-68sukdb1	771	24	Pyruvate	Pyruvate	NNP
cord-295807-68sukdb1	771	25	in	in	IN
cord-295807-68sukdb1	771	26	the	the	DT
cord-295807-68sukdb1	771	27	correction	correction	NN
cord-295807-68sukdb1	771	28	of	of	IN
cord-295807-68sukdb1	771	29	intracellular	intracellular	JJ
cord-295807-68sukdb1	771	30	acidosis	acidosis	NN
cord-295807-68sukdb1	771	31	:	:	:
cord-295807-68sukdb1	771	32	a	a	DT
cord-295807-68sukdb1	771	33	metabolic	metabolic	JJ
cord-295807-68sukdb1	771	34	basis	basis	NN
cord-295807-68sukdb1	771	35	as	as	IN
cord-295807-68sukdb1	771	36	a	a	DT
cord-295807-68sukdb1	771	37	novel	novel	JJ
cord-295807-68sukdb1	771	38	superior	superior	JJ
cord-295807-68sukdb1	771	39	buffer	buffer	NN
cord-295807-68sukdb1	771	40	A	a	DT
cord-295807-68sukdb1	771	41	controlled	control	VBN
cord-295807-68sukdb1	771	42	clinical	clinical	JJ
cord-295807-68sukdb1	771	43	trial	trial	NN
cord-295807-68sukdb1	771	44	of	of	IN
cord-295807-68sukdb1	771	45	dichloroacetate	dichloroacetate	NN
cord-295807-68sukdb1	771	46	for	for	IN
cord-295807-68sukdb1	771	47	treatment	treatment	NN
cord-295807-68sukdb1	771	48	of	of	IN
cord-295807-68sukdb1	771	49	lactic	lactic	JJ
cord-295807-68sukdb1	771	50	acidosis	acidosis	NN
cord-295807-68sukdb1	771	51	in	in	IN
cord-295807-68sukdb1	771	52	adults	adult	NNS
cord-295807-68sukdb1	771	53	.	.	.
cord-295807-68sukdb1	772	1	The	the	DT
cord-295807-68sukdb1	772	2	Dichloroacetate	Dichloroacetate	NNP
cord-295807-68sukdb1	772	3	-	-	HYPH
cord-295807-68sukdb1	772	4	Lactic	Lactic	NNP
cord-295807-68sukdb1	772	5	Acidosis	Acidosis	NNP
cord-295807-68sukdb1	772	6	Study	Study	NNP
cord-295807-68sukdb1	772	7	Group	Group	NNP
cord-295807-68sukdb1	772	8	Pathophysiology	Pathophysiology	NNP
cord-295807-68sukdb1	772	9	of	of	IN
cord-295807-68sukdb1	772	10	metabolic	metabolic	JJ
cord-295807-68sukdb1	772	11	alkalosis	alkalosis	NN
cord-295807-68sukdb1	772	12	:	:	:
cord-295807-68sukdb1	772	13	a	a	DT
cord-295807-68sukdb1	772	14	new	new	JJ
cord-295807-68sukdb1	772	15	classification	classification	NN
cord-295807-68sukdb1	772	16	based	base	VBN
cord-295807-68sukdb1	772	17	on	on	IN
cord-295807-68sukdb1	772	18	the	the	DT
cord-295807-68sukdb1	772	19	centrality	centrality	NN
cord-295807-68sukdb1	772	20	of	of	IN
cord-295807-68sukdb1	772	21	stimulated	stimulate	VBN
cord-295807-68sukdb1	772	22	collecting	collect	VBG
cord-295807-68sukdb1	772	23	duct	duct	NN
cord-295807-68sukdb1	772	24	ion	ion	NN
cord-295807-68sukdb1	772	25	transport	transport	NN
cord-295807-68sukdb1	772	26	Acetazolamide	Acetazolamide	NNP
cord-295807-68sukdb1	772	27	-	-	HYPH
cord-295807-68sukdb1	772	28	mediated	mediate	VBN
cord-295807-68sukdb1	772	29	decrease	decrease	NN
cord-295807-68sukdb1	772	30	in	in	IN
cord-295807-68sukdb1	772	31	strong	strong	JJ
cord-295807-68sukdb1	772	32	ion	ion	NN
cord-295807-68sukdb1	772	33	difference	difference	NN
cord-295807-68sukdb1	772	34	accounts	account	VBZ
cord-295807-68sukdb1	772	35	for	for	IN
cord-295807-68sukdb1	772	36	the	the	DT
cord-295807-68sukdb1	772	37	correction	correction	NN
cord-295807-68sukdb1	772	38	of	of	IN
cord-295807-68sukdb1	772	39	metabolic	metabolic	JJ
cord-295807-68sukdb1	772	40	alkalosis	alkalosis	NN
cord-295807-68sukdb1	772	41	in	in	IN
cord-295807-68sukdb1	772	42	critically	critically	RB
cord-295807-68sukdb1	772	43	ill	ill	JJ
cord-295807-68sukdb1	772	44	patients	patient	NNS
cord-295807-68sukdb1	772	45	Hydrochloric	hydrochloric	JJ
cord-295807-68sukdb1	772	46	Acid	acid	NN
cord-295807-68sukdb1	772	47	Infusion	infusion	NN
cord-295807-68sukdb1	772	48	for	for	IN
cord-295807-68sukdb1	772	49	the	the	DT
cord-295807-68sukdb1	772	50	Treatment	Treatment	NNP
cord-295807-68sukdb1	772	51	of	of	IN
cord-295807-68sukdb1	772	52	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	772	53	Alkalosis	Alkalosis	NNP
cord-295807-68sukdb1	772	54	in	in	IN
cord-295807-68sukdb1	772	55	Surgical	Surgical	NNP
cord-295807-68sukdb1	772	56	Intensive	Intensive	NNP
cord-295807-68sukdb1	772	57	Care	Care	NNP
cord-295807-68sukdb1	772	58	Unit	Unit	NNP
cord-295807-68sukdb1	772	59	Patients	patient	VBZ
cord-295807-68sukdb1	772	60	Cimetidine	Cimetidine	NNP
cord-295807-68sukdb1	772	61	in	in	IN
cord-295807-68sukdb1	772	62	the	the	DT
cord-295807-68sukdb1	772	63	Management	Management	NNP
cord-295807-68sukdb1	772	64	of	of	IN
cord-295807-68sukdb1	772	65	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	772	66	Alkalosis	Alkalosis	NNP
cord-295807-68sukdb1	772	67	Induced	induce	VBN
cord-295807-68sukdb1	772	68	by	by	IN
cord-295807-68sukdb1	772	69	Nasogastric	Nasogastric	NNP
cord-295807-68sukdb1	772	70	Drainage	Drainage	NNP
cord-295807-68sukdb1	772	71	Respiratory	respiratory	JJ
cord-295807-68sukdb1	772	72	Acid	acid	NN
cord-295807-68sukdb1	772	73	-	-	HYPH
cord-295807-68sukdb1	772	74	Base	Base	NNP
cord-295807-68sukdb1	772	75	Disorders	Disorders	NNPS
cord-295807-68sukdb1	772	76	National	National	NNP
cord-295807-68sukdb1	772	77	Kidney	Kidney	NNP
cord-295807-68sukdb1	772	78	Foundation	Foundation	NNP
cord-295807-68sukdb1	772	79	Primer	Primer	NNP
cord-295807-68sukdb1	772	80	on	on	IN
cord-295807-68sukdb1	772	81	Kidney	Kidney	NNP
cord-295807-68sukdb1	772	82	Diseases	disease	NNS
cord-295807-68sukdb1	772	83	Acid	acid	NN
cord-295807-68sukdb1	772	84	-	-	HYPH
cord-295807-68sukdb1	772	85	base	base	NN
cord-295807-68sukdb1	772	86	transport	transport	NN
cord-295807-68sukdb1	772	87	by	by	IN
cord-295807-68sukdb1	772	88	the	the	DT
cord-295807-68sukdb1	772	89	renal	renal	JJ
cord-295807-68sukdb1	772	90	proximal	proximal	JJ
cord-295807-68sukdb1	772	91	tubule	tubule	NN
cord-295807-68sukdb1	772	92	StatPearls	StatPearls	NNP
cord-295807-68sukdb1	772	93	,	,	,
cord-295807-68sukdb1	772	94	StatPearls	StatPearls	NNP
cord-295807-68sukdb1	772	95	Publishing	Publishing	NNP
cord-295807-68sukdb1	772	96	Alkali	Alkali	NNP
cord-295807-68sukdb1	772	97	Therapy	Therapy	NNP
cord-295807-68sukdb1	772	98	for	for	IN
cord-295807-68sukdb1	772	99	Respiratory	respiratory	JJ
cord-295807-68sukdb1	772	100	Acidosis	acidosis	NN
cord-295807-68sukdb1	772	101	:	:	:
cord-295807-68sukdb1	773	1	A	a	DT
cord-295807-68sukdb1	773	2	Medical	Medical	NNP
cord-295807-68sukdb1	773	3	Controversy	controversy	NN
cord-295807-68sukdb1	773	4	Acetazolamide	Acetazolamide	NNP
cord-295807-68sukdb1	773	5	Use	Use	NNP
cord-295807-68sukdb1	773	6	in	in	IN
cord-295807-68sukdb1	773	7	Severe	severe	JJ
cord-295807-68sukdb1	773	8	Chronic	Chronic	NNP
cord-295807-68sukdb1	773	9	Obstructive	obstructive	JJ
cord-295807-68sukdb1	773	10	Pulmonary	Pulmonary	NNP
cord-295807-68sukdb1	773	11	Disease	Disease	NNP
cord-295807-68sukdb1	773	12	.	.	.
cord-295807-68sukdb1	774	1	Pros	pro	NNS
cord-295807-68sukdb1	774	2	and	and	CC
cord-295807-68sukdb1	774	3	Cons	Cons	NNPS
cord-295807-68sukdb1	774	4	Acidic	acidic	JJ
cord-295807-68sukdb1	774	5	sweep	sweep	NN
cord-295807-68sukdb1	774	6	gas	gas	NN
cord-295807-68sukdb1	774	7	with	with	IN
cord-295807-68sukdb1	774	8	carbonic	carbonic	JJ
cord-295807-68sukdb1	774	9	anhydrase	anhydrase	NN
cord-295807-68sukdb1	774	10	coated	coat	VBN
cord-295807-68sukdb1	774	11	hollow	hollow	JJ
cord-295807-68sukdb1	774	12	fiber	fiber	NN
cord-295807-68sukdb1	774	13	membranes	membrane	NNS
cord-295807-68sukdb1	774	14	synergistically	synergistically	RB
cord-295807-68sukdb1	774	15	accelerates	accelerate	VBZ
cord-295807-68sukdb1	774	16	CO2	CO2	NNP
cord-295807-68sukdb1	774	17	removal	removal	NN
cord-295807-68sukdb1	774	18	from	from	IN
cord-295807-68sukdb1	774	19	blood	blood	NN
cord-295807-68sukdb1	775	1	A	a	DT
cord-295807-68sukdb1	775	2	Proof	Proof	NNP
cord-295807-68sukdb1	775	3	of	of	IN
cord-295807-68sukdb1	775	4	Concept	Concept	NNP
cord-295807-68sukdb1	775	5	Study	Study	NNP
cord-295807-68sukdb1	775	6	,	,	,
cord-295807-68sukdb1	775	7	Demonstrating	demonstrate	VBG
cord-295807-68sukdb1	775	8	Extracorporeal	extracorporeal	JJ
cord-295807-68sukdb1	775	9	Carbon	carbon	NN
cord-295807-68sukdb1	775	10	Dioxide	dioxide	NN
cord-295807-68sukdb1	775	11	Removal	removal	NN
cord-295807-68sukdb1	775	12	Using	use	VBG
cord-295807-68sukdb1	775	13	Hemodialysis	Hemodialysis	NNP
cord-295807-68sukdb1	775	14	with	with	IN
cord-295807-68sukdb1	775	15	a	a	DT
cord-295807-68sukdb1	775	16	Low	Low	NNP
cord-295807-68sukdb1	775	17	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	775	18	Dialysate	Dialysate	NNP
cord-295807-68sukdb1	775	19	Hormone	Hormone	NNP
cord-295807-68sukdb1	775	20	replacement	replacement	NN
cord-295807-68sukdb1	775	21	therapy	therapy	NN
cord-295807-68sukdb1	775	22	causes	cause	VBZ
cord-295807-68sukdb1	775	23	a	a	DT
cord-295807-68sukdb1	775	24	respiratory	respiratory	JJ
cord-295807-68sukdb1	775	25	alkalosis	alkalosis	NN
cord-295807-68sukdb1	775	26	in	in	IN
cord-295807-68sukdb1	775	27	normal	normal	JJ
cord-295807-68sukdb1	775	28	postmenopausal	postmenopausal	JJ
cord-295807-68sukdb1	775	29	women	woman	NNS
cord-295807-68sukdb1	775	30	Mechanisms	Mechanisms	NNPS
cord-295807-68sukdb1	775	31	of	of	IN
cord-295807-68sukdb1	775	32	action	action	NN
cord-295807-68sukdb1	775	33	of	of	IN
cord-295807-68sukdb1	775	34	acetazolamide	acetazolamide	NN
cord-295807-68sukdb1	775	35	in	in	IN
cord-295807-68sukdb1	775	36	the	the	DT
cord-295807-68sukdb1	775	37	prophylaxis	prophylaxis	NN
cord-295807-68sukdb1	775	38	and	and	CC
cord-295807-68sukdb1	775	39	treatment	treatment	NN
cord-295807-68sukdb1	775	40	of	of	IN
cord-295807-68sukdb1	775	41	acute	acute	JJ
cord-295807-68sukdb1	775	42	mountain	mountain	NN
cord-295807-68sukdb1	775	43	sickness	sickness	NN
cord-295807-68sukdb1	775	44	Minireview	Minireview	NNP
cord-295807-68sukdb1	775	45	:	:	:
cord-295807-68sukdb1	776	1	pH	pH	NNP
cord-295807-68sukdb1	776	2	and	and	CC
cord-295807-68sukdb1	776	3	synaptic	synaptic	JJ
cord-295807-68sukdb1	776	4	transmission	transmission	NN
cord-295807-68sukdb1	777	1	Protons	proton	NNS
cord-295807-68sukdb1	777	2	are	be	VBP
cord-295807-68sukdb1	777	3	a	a	DT
cord-295807-68sukdb1	777	4	neurotransmitter	neurotransmitter	NN
cord-295807-68sukdb1	777	5	that	that	WDT
cord-295807-68sukdb1	777	6	regulates	regulate	VBZ
cord-295807-68sukdb1	777	7	synaptic	synaptic	JJ
cord-295807-68sukdb1	777	8	plasticity	plasticity	NN
cord-295807-68sukdb1	777	9	in	in	IN
cord-295807-68sukdb1	777	10	the	the	DT
cord-295807-68sukdb1	777	11	lateral	lateral	JJ
cord-295807-68sukdb1	777	12	amygdala	amygdala	NN
cord-295807-68sukdb1	777	13	Role	Role	NNP
cord-295807-68sukdb1	777	14	of	of	IN
cord-295807-68sukdb1	777	15	HCO3-ions	hco3-ion	NNS
cord-295807-68sukdb1	777	16	in	in	IN
cord-295807-68sukdb1	777	17	depolarizing	depolarize	VBG
cord-295807-68sukdb1	777	18	GABAA	GABAA	NNP
cord-295807-68sukdb1	777	19	receptor	receptor	NN
cord-295807-68sukdb1	777	20	-	-	HYPH
cord-295807-68sukdb1	777	21	mediated	mediate	VBN
cord-295807-68sukdb1	777	22	responses	response	NNS
cord-295807-68sukdb1	777	23	in	in	IN
cord-295807-68sukdb1	777	24	pyramidal	pyramidal	JJ
cord-295807-68sukdb1	777	25	cells	cell	NNS
cord-295807-68sukdb1	777	26	of	of	IN
cord-295807-68sukdb1	777	27	rat	rat	NN
cord-295807-68sukdb1	777	28	hippocampus	hippocampus	NN
cord-295807-68sukdb1	777	29	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	777	30	efflux	efflux	NN
cord-295807-68sukdb1	777	31	via	via	IN
cord-295807-68sukdb1	777	32	GABAA	GABAA	NNP
cord-295807-68sukdb1	777	33	receptors	receptor	NNS
cord-295807-68sukdb1	777	34	depolarizes	depolarize	VBZ
cord-295807-68sukdb1	777	35	membrane	membrane	NN
cord-295807-68sukdb1	777	36	potential	potential	NN
cord-295807-68sukdb1	777	37	and	and	CC
cord-295807-68sukdb1	777	38	inhibits	inhibit	VBZ
cord-295807-68sukdb1	777	39	two	two	CD
cord-295807-68sukdb1	777	40	-	-	HYPH
cord-295807-68sukdb1	777	41	pore	pore	NN
cord-295807-68sukdb1	777	42	domain	domain	NN
cord-295807-68sukdb1	777	43	potassium	potassium	NN
cord-295807-68sukdb1	777	44	channels	channel	NNS
cord-295807-68sukdb1	777	45	of	of	IN
cord-295807-68sukdb1	777	46	astrocytes	astrocyte	NNS
cord-295807-68sukdb1	777	47	in	in	IN
cord-295807-68sukdb1	777	48	rat	rat	NN
cord-295807-68sukdb1	777	49	hippocampal	hippocampal	JJ
cord-295807-68sukdb1	777	50	slices	slice	NNS
cord-295807-68sukdb1	778	1	Rapid	rapid	JJ
cord-295807-68sukdb1	778	2	rise	rise	NN
cord-295807-68sukdb1	778	3	of	of	IN
cord-295807-68sukdb1	778	4	extracellular	extracellular	JJ
cord-295807-68sukdb1	778	5	pH	ph	NN
cord-295807-68sukdb1	778	6	evoked	evoke	VBN
cord-295807-68sukdb1	778	7	by	by	IN
cord-295807-68sukdb1	778	8	neural	neural	JJ
cord-295807-68sukdb1	778	9	activity	activity	NN
cord-295807-68sukdb1	778	10	is	be	VBZ
cord-295807-68sukdb1	778	11	generated	generate	VBN
cord-295807-68sukdb1	778	12	by	by	IN
cord-295807-68sukdb1	778	13	the	the	DT
cord-295807-68sukdb1	778	14	plasma	plasma	NN
cord-295807-68sukdb1	778	15	membrane	membrane	NN
cord-295807-68sukdb1	778	16	calcium	calcium	NN
cord-295807-68sukdb1	778	17	ATPase	ATPase	NNP
cord-295807-68sukdb1	778	18	Regulation	Regulation	NNP
cord-295807-68sukdb1	778	19	and	and	CC
cord-295807-68sukdb1	778	20	Modulation	Modulation	NNP
cord-295807-68sukdb1	778	21	of	of	IN
cord-295807-68sukdb1	778	22	pH	ph	NN
cord-295807-68sukdb1	778	23	in	in	IN
cord-295807-68sukdb1	778	24	the	the	DT
cord-295807-68sukdb1	778	25	Brain	Brain	NNP
cord-295807-68sukdb1	778	26	Seizure	Seizure	NNP
cord-295807-68sukdb1	778	27	termination	termination	NN
cord-295807-68sukdb1	778	28	by	by	IN
cord-295807-68sukdb1	778	29	acidosis	acidosis	NN
cord-295807-68sukdb1	778	30	depends	depend	VBZ
cord-295807-68sukdb1	778	31	on	on	IN
cord-295807-68sukdb1	778	32	ASIC1a	ASIC1a	NNP
cord-295807-68sukdb1	778	33	Cull	Cull	NNP
cord-295807-68sukdb1	778	34	-	-	HYPH
cord-295807-68sukdb1	778	35	Candy	Candy	NNP
cord-295807-68sukdb1	778	36	,	,	,
cord-295807-68sukdb1	778	37	Proton	proton	NN
cord-295807-68sukdb1	778	38	inhibition	inhibition	NN
cord-295807-68sukdb1	778	39	of	of	IN
cord-295807-68sukdb1	778	40	N	n	NN
cord-295807-68sukdb1	778	41	-	-	HYPH
cord-295807-68sukdb1	778	42	methyl	methyl	NN
cord-295807-68sukdb1	778	43	-	-	HYPH
cord-295807-68sukdb1	778	44	D	d	NN
cord-295807-68sukdb1	778	45	-	-	HYPH
cord-295807-68sukdb1	778	46	aspartate	aspartate	JJ
cord-295807-68sukdb1	778	47	receptors	receptor	NNS
cord-295807-68sukdb1	778	48	in	in	IN
cord-295807-68sukdb1	778	49	cerebellar	cerebellar	JJ
cord-295807-68sukdb1	778	50	neurons	neuron	NNS
cord-295807-68sukdb1	779	1	Brain	brain	NN
cord-295807-68sukdb1	779	2	alkalosis	alkalosis	NN
cord-295807-68sukdb1	779	3	causes	cause	VBZ
cord-295807-68sukdb1	779	4	birth	birth	NN
cord-295807-68sukdb1	779	5	asphyxia	asphyxia	NN
cord-295807-68sukdb1	779	6	seizures	seizure	NNS
cord-295807-68sukdb1	779	7	,	,	,
cord-295807-68sukdb1	779	8	suggesting	suggest	VBG
cord-295807-68sukdb1	779	9	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	779	10	strategy	strategy	NN
cord-295807-68sukdb1	779	11	Emerging	emerge	VBG
cord-295807-68sukdb1	779	12	roles	role	NNS
cord-295807-68sukdb1	779	13	of	of	IN
cord-295807-68sukdb1	779	14	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	779	15	exchangers	exchanger	NNS
cord-295807-68sukdb1	779	16	in	in	IN
cord-295807-68sukdb1	779	17	epilepsy	epilepsy	NN
cord-295807-68sukdb1	779	18	and	and	CC
cord-295807-68sukdb1	779	19	developmental	developmental	JJ
cord-295807-68sukdb1	779	20	brain	brain	NN
cord-295807-68sukdb1	780	1	disorders	disorders	NNPS
cord-295807-68sukdb1	780	2	Disruption	Disruption	NNP
cord-295807-68sukdb1	780	3	of	of	IN
cord-295807-68sukdb1	780	4	sodium	sodium	NN
cord-295807-68sukdb1	780	5	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	780	6	transporter	transporter	NN
cord-295807-68sukdb1	780	7	SLC4A10	SLC4A10	NNP
cord-295807-68sukdb1	780	8	in	in	IN
cord-295807-68sukdb1	780	9	a	a	DT
cord-295807-68sukdb1	780	10	patient	patient	NN
cord-295807-68sukdb1	780	11	with	with	IN
cord-295807-68sukdb1	780	12	complex	complex	JJ
cord-295807-68sukdb1	780	13	partial	partial	JJ
cord-295807-68sukdb1	780	14	epilepsy	epilepsy	NN
cord-295807-68sukdb1	780	15	and	and	CC
cord-295807-68sukdb1	780	16	mental	mental	NNP
cord-295807-68sukdb1	780	17	retardation	retardation	NNP
cord-295807-68sukdb1	780	18	Association	Association	NNP
cord-295807-68sukdb1	780	19	of	of	IN
cord-295807-68sukdb1	780	20	the	the	DT
cord-295807-68sukdb1	780	21	867Asp	867asp	CD
cord-295807-68sukdb1	780	22	variant	variant	NN
cord-295807-68sukdb1	780	23	of	of	IN
cord-295807-68sukdb1	780	24	the	the	DT
cord-295807-68sukdb1	780	25	human	human	JJ
cord-295807-68sukdb1	780	26	anion	anion	NN
cord-295807-68sukdb1	780	27	exchanger	exchanger	NN
cord-295807-68sukdb1	780	28	3	3	CD
cord-295807-68sukdb1	780	29	gene	gene	NN
cord-295807-68sukdb1	780	30	with	with	IN
cord-295807-68sukdb1	780	31	common	common	JJ
cord-295807-68sukdb1	780	32	subtypes	subtype	NNS
cord-295807-68sukdb1	780	33	of	of	IN
cord-295807-68sukdb1	780	34	idiopathic	idiopathic	JJ
cord-295807-68sukdb1	780	35	generalized	generalized	JJ
cord-295807-68sukdb1	780	36	epilepsy	epilepsy	NN
cord-295807-68sukdb1	781	1	Na	Na	NNP
cord-295807-68sukdb1	781	2	+	+	CC
cord-295807-68sukdb1	781	3	dependent	dependent	JJ
cord-295807-68sukdb1	781	4	acid	acid	NN
cord-295807-68sukdb1	781	5	-	-	HYPH
cord-295807-68sukdb1	781	6	base	base	NN
cord-295807-68sukdb1	781	7	transporters	transporter	NNS
cord-295807-68sukdb1	781	8	in	in	IN
cord-295807-68sukdb1	781	9	the	the	DT
cord-295807-68sukdb1	781	10	choroid	choroid	JJ
cord-295807-68sukdb1	781	11	plexus	plexus	NN
cord-295807-68sukdb1	781	12	;	;	:
cord-295807-68sukdb1	781	13	insights	insight	NNS
cord-295807-68sukdb1	781	14	from	from	IN
cord-295807-68sukdb1	781	15	slc4	slc4	NN
cord-295807-68sukdb1	781	16	and	and	CC
cord-295807-68sukdb1	781	17	slc9	slc9	NN
cord-295807-68sukdb1	782	1	gene	gene	NN
cord-295807-68sukdb1	782	2	deletion	deletion	NN
cord-295807-68sukdb1	782	3	studies	study	NNS
cord-295807-68sukdb1	782	4	Acetazolamide	Acetazolamide	NNP
cord-295807-68sukdb1	782	5	lowers	lower	VBZ
cord-295807-68sukdb1	782	6	intracranial	intracranial	JJ
cord-295807-68sukdb1	782	7	pressure	pressure	NN
cord-295807-68sukdb1	782	8	and	and	CC
cord-295807-68sukdb1	782	9	modulates	modulate	VBZ
cord-295807-68sukdb1	782	10	the	the	DT
cord-295807-68sukdb1	782	11	cerebrospinal	cerebrospinal	JJ
cord-295807-68sukdb1	782	12	fluid	fluid	JJ
cord-295807-68sukdb1	782	13	secretion	secretion	NN
cord-295807-68sukdb1	782	14	pathway	pathway	NN
cord-295807-68sukdb1	782	15	in	in	IN
cord-295807-68sukdb1	782	16	healthy	healthy	JJ
cord-295807-68sukdb1	782	17	rats	rat	NNS
cord-295807-68sukdb1	782	18	Ionic	Ionic	NNP
cord-295807-68sukdb1	782	19	mechanisms	mechanism	NNS
cord-295807-68sukdb1	782	20	of	of	IN
cord-295807-68sukdb1	782	21	neuronal	neuronal	JJ
cord-295807-68sukdb1	782	22	excitation	excitation	NN
cord-295807-68sukdb1	782	23	by	by	IN
cord-295807-68sukdb1	782	24	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	782	25	GABAA	GABAA	NNP
cord-295807-68sukdb1	782	26	receptors	receptor	NNS
cord-295807-68sukdb1	783	1	The	the	DT
cord-295807-68sukdb1	783	2	GABA	GABA	NNP
cord-295807-68sukdb1	783	3	excitatory	excitatory	JJ
cord-295807-68sukdb1	783	4	/	/	SYM
cord-295807-68sukdb1	783	5	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	783	6	developmental	developmental	JJ
cord-295807-68sukdb1	783	7	sequence	sequence	NN
cord-295807-68sukdb1	783	8	:	:	:
cord-295807-68sukdb1	784	1	a	a	DT
cord-295807-68sukdb1	784	2	personal	personal	JJ
cord-295807-68sukdb1	784	3	journey	journey	NN
cord-295807-68sukdb1	784	4	Chloride	chloride	NN
cord-295807-68sukdb1	784	5	concentration	concentration	NN
cord-295807-68sukdb1	784	6	in	in	IN
cord-295807-68sukdb1	784	7	cultured	cultured	JJ
cord-295807-68sukdb1	784	8	hippocampal	hippocampal	JJ
cord-295807-68sukdb1	784	9	neurons	neuron	NNS
cord-295807-68sukdb1	784	10	increases	increase	VBZ
cord-295807-68sukdb1	784	11	during	during	IN
cord-295807-68sukdb1	784	12	long	long	JJ
cord-295807-68sukdb1	784	13	-	-	HYPH
cord-295807-68sukdb1	784	14	term	term	NN
cord-295807-68sukdb1	784	15	exposure	exposure	NN
cord-295807-68sukdb1	784	16	to	to	IN
cord-295807-68sukdb1	784	17	ammonia	ammonia	NN
cord-295807-68sukdb1	784	18	through	through	IN
cord-295807-68sukdb1	784	19	enhanced	enhanced	JJ
cord-295807-68sukdb1	784	20	expression	expression	NN
cord-295807-68sukdb1	784	21	of	of	IN
cord-295807-68sukdb1	784	22	an	an	DT
cord-295807-68sukdb1	784	23	anion	anion	NN
cord-295807-68sukdb1	784	24	exchanger	exchanger	NN
cord-295807-68sukdb1	784	25	A	a	DT
cord-295807-68sukdb1	784	26	Christianson	Christianson	NNP
cord-295807-68sukdb1	784	27	syndromelinked	syndromelinked	JJ
cord-295807-68sukdb1	784	28	deletion	deletion	NN
cord-295807-68sukdb1	784	29	mutation	mutation	NN
cord-295807-68sukdb1	784	30	(	(	-LRB-
cord-295807-68sukdb1	784	31	Δ287ES288	Δ287ES288	NNP
cord-295807-68sukdb1	784	32	)	)	-RRB-
cord-295807-68sukdb1	785	1	in	in	IN
cord-295807-68sukdb1	785	2	SLC9A6	SLC9A6	NNP
cord-295807-68sukdb1	785	3	impairs	impair	VBZ
cord-295807-68sukdb1	785	4	hippocampal	hippocampal	JJ
cord-295807-68sukdb1	785	5	neuronal	neuronal	JJ
cord-295807-68sukdb1	785	6	plasticity	plasticity	NN
cord-295807-68sukdb1	785	7	Cerebral	cerebral	JJ
cord-295807-68sukdb1	785	8	acidosis	acidosis	NN
cord-295807-68sukdb1	785	9	in	in	IN
cord-295807-68sukdb1	785	10	focal	focal	JJ
cord-295807-68sukdb1	785	11	ischemia	ischemia	NN
cord-295807-68sukdb1	786	1	Dramatic	dramatic	JJ
cord-295807-68sukdb1	786	2	aggregation	aggregation	NN
cord-295807-68sukdb1	786	3	of	of	IN
cord-295807-68sukdb1	786	4	Alzheimer	Alzheimer	NNP
cord-295807-68sukdb1	786	5	abeta	abeta	NN
cord-295807-68sukdb1	786	6	by	by	IN
cord-295807-68sukdb1	786	7	Cu(II	Cu(II	NNP
cord-295807-68sukdb1	786	8	)	)	-RRB-
cord-295807-68sukdb1	786	9	is	be	VBZ
cord-295807-68sukdb1	786	10	induced	induce	VBN
cord-295807-68sukdb1	786	11	by	by	IN
cord-295807-68sukdb1	786	12	conditions	condition	NNS
cord-295807-68sukdb1	786	13	representing	represent	VBG
cord-295807-68sukdb1	786	14	physiological	physiological	JJ
cord-295807-68sukdb1	786	15	acidosis	acidosis	NN
cord-295807-68sukdb1	786	16	Amyloid	amyloid	NN
cord-295807-68sukdb1	786	17	clearance	clearance	NN
cord-295807-68sukdb1	786	18	defect	defect	NN
cord-295807-68sukdb1	786	19	in	in	IN
cord-295807-68sukdb1	786	20	ApoE4	ApoE4	NNP
cord-295807-68sukdb1	786	21	astrocytes	astrocyte	NNS
cord-295807-68sukdb1	786	22	is	be	VBZ
cord-295807-68sukdb1	786	23	reversed	reverse	VBN
cord-295807-68sukdb1	786	24	by	by	IN
cord-295807-68sukdb1	786	25	epigenetic	epigenetic	JJ
cord-295807-68sukdb1	786	26	correction	correction	NN
cord-295807-68sukdb1	786	27	of	of	IN
cord-295807-68sukdb1	786	28	endosomal	endosomal	NNP
cord-295807-68sukdb1	787	1	pH	pH	NNP
cord-295807-68sukdb1	787	2	5	5	CD
cord-295807-68sukdb1	787	3	%	%	NN
cord-295807-68sukdb1	787	4	CO2	co2	NN
cord-295807-68sukdb1	787	5	is	be	VBZ
cord-295807-68sukdb1	787	6	a	a	DT
cord-295807-68sukdb1	787	7	potent	potent	JJ
cord-295807-68sukdb1	787	8	,	,	,
cord-295807-68sukdb1	787	9	fast	fast	RB
cord-295807-68sukdb1	787	10	acting	act	VBG
cord-295807-68sukdb1	787	11	inhalation	inhalation	NN
cord-295807-68sukdb1	787	12	anticonvulsant	anticonvulsant	JJ
cord-295807-68sukdb1	788	1	The	the	DT
cord-295807-68sukdb1	788	2	role	role	NN
cord-295807-68sukdb1	788	3	of	of	IN
cord-295807-68sukdb1	788	4	carbon	carbon	NN
cord-295807-68sukdb1	788	5	dioxide	dioxide	NN
cord-295807-68sukdb1	788	6	in	in	IN
cord-295807-68sukdb1	788	7	acute	acute	JJ
cord-295807-68sukdb1	788	8	brain	brain	NN
cord-295807-68sukdb1	788	9	injury	injury	NN
cord-295807-68sukdb1	789	1	A	a	DT
cord-295807-68sukdb1	789	2	novel	novel	JJ
cord-295807-68sukdb1	789	3	neuroprotective	neuroprotective	JJ
cord-295807-68sukdb1	789	4	strategy	strategy	NN
cord-295807-68sukdb1	789	5	for	for	IN
cord-295807-68sukdb1	789	6	ischemic	ischemic	JJ
cord-295807-68sukdb1	789	7	stroke	stroke	NN
cord-295807-68sukdb1	789	8	:	:	:
cord-295807-68sukdb1	789	9	transient	transient	JJ
cord-295807-68sukdb1	789	10	mild	mild	JJ
cord-295807-68sukdb1	789	11	acidosis	acidosis	NN
cord-295807-68sukdb1	789	12	treatment	treatment	NN
cord-295807-68sukdb1	789	13	by	by	IN
cord-295807-68sukdb1	789	14	CO2	CO2	NNP
cord-295807-68sukdb1	789	15	inhalation	inhalation	NN
cord-295807-68sukdb1	789	16	at	at	IN
cord-295807-68sukdb1	789	17	reperfusion	reperfusion	NN
cord-295807-68sukdb1	789	18	Acetazolamide	Acetazolamide	NNP
cord-295807-68sukdb1	789	19	in	in	IN
cord-295807-68sukdb1	789	20	the	the	DT
cord-295807-68sukdb1	789	21	treatment	treatment	NN
cord-295807-68sukdb1	789	22	of	of	IN
cord-295807-68sukdb1	789	23	seizures	seizure	NNS
cord-295807-68sukdb1	790	1	A	a	DT
cord-295807-68sukdb1	790	2	class	class	NN
cord-295807-68sukdb1	790	3	of	of	IN
cord-295807-68sukdb1	790	4	sulfonamide	sulfonamide	NN
cord-295807-68sukdb1	790	5	carbonic	carbonic	JJ
cord-295807-68sukdb1	790	6	anhydrase	anhydrase	NN
cord-295807-68sukdb1	790	7	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	790	8	with	with	IN
cord-295807-68sukdb1	790	9	neuropathic	neuropathic	JJ
cord-295807-68sukdb1	790	10	pain	pain	NN
cord-295807-68sukdb1	790	11	modulating	modulate	VBG
cord-295807-68sukdb1	790	12	effects	effect	NNS
cord-295807-68sukdb1	791	1	A	a	DT
cord-295807-68sukdb1	791	2	New	New	NNP
cord-295807-68sukdb1	791	3	Kid	Kid	NNP
cord-295807-68sukdb1	791	4	on	on	IN
cord-295807-68sukdb1	791	5	the	the	DT
cord-295807-68sukdb1	791	6	Block	Block	NNP
cord-295807-68sukdb1	791	7	?	?	.
cord-295807-68sukdb1	792	1	Carbonic	carbonic	JJ
cord-295807-68sukdb1	792	2	Anhydrases	Anhydrases	NNP
cord-295807-68sukdb1	792	3	as	as	IN
cord-295807-68sukdb1	792	4	Possible	possible	JJ
cord-295807-68sukdb1	792	5	New	New	NNP
cord-295807-68sukdb1	792	6	Targets	Targets	NNPS
cord-295807-68sukdb1	792	7	in	in	IN
cord-295807-68sukdb1	792	8	Alzheimer	Alzheimer	NNP
cord-295807-68sukdb1	792	9	's	's	POS
cord-295807-68sukdb1	792	10	Disease	Disease	NNP
cord-295807-68sukdb1	792	11	Carbonic	Carbonic	NNP
cord-295807-68sukdb1	792	12	anhydrase	anhydrase	NN
cord-295807-68sukdb1	792	13	modulation	modulation	NN
cord-295807-68sukdb1	792	14	of	of	IN
cord-295807-68sukdb1	792	15	emotional	emotional	JJ
cord-295807-68sukdb1	792	16	memory	memory	NN
cord-295807-68sukdb1	792	17	.	.	.
cord-295807-68sukdb1	793	1	Implications	implication	NNS
cord-295807-68sukdb1	793	2	for	for	IN
cord-295807-68sukdb1	793	3	the	the	DT
cord-295807-68sukdb1	793	4	treatment	treatment	NN
cord-295807-68sukdb1	793	5	of	of	IN
cord-295807-68sukdb1	793	6	cognitive	cognitive	JJ
cord-295807-68sukdb1	793	7	disorders	disorder	NNS
cord-295807-68sukdb1	793	8	Type	Type	NNP
cord-295807-68sukdb1	793	9	II	II	NNP
cord-295807-68sukdb1	793	10	Renal	Renal	NNP
cord-295807-68sukdb1	793	11	Tubular	Tubular	NNP
cord-295807-68sukdb1	793	12	Acidosis	Acidosis	NNP
cord-295807-68sukdb1	793	13	Secondary	Secondary	NNP
cord-295807-68sukdb1	793	14	to	to	IN
cord-295807-68sukdb1	793	15	Topiramate	topiramate	NN
cord-295807-68sukdb1	793	16	:	:	:
cord-295807-68sukdb1	794	1	A	a	DT
cord-295807-68sukdb1	794	2	Review	Review	NNP
cord-295807-68sukdb1	794	3	Disruption	Disruption	NNP
cord-295807-68sukdb1	794	4	of	of	IN
cord-295807-68sukdb1	794	5	Slc4a10	Slc4a10	NNP
cord-295807-68sukdb1	794	6	augments	augment	VBZ
cord-295807-68sukdb1	794	7	neuronal	neuronal	JJ
cord-295807-68sukdb1	794	8	excitability	excitability	NN
cord-295807-68sukdb1	794	9	and	and	CC
cord-295807-68sukdb1	794	10	modulates	modulate	VBZ
cord-295807-68sukdb1	794	11	synaptic	synaptic	JJ
cord-295807-68sukdb1	794	12	short	short	JJ
cord-295807-68sukdb1	794	13	-	-	HYPH
cord-295807-68sukdb1	794	14	term	term	NN
cord-295807-68sukdb1	794	15	plasticity	plasticity	NN
cord-295807-68sukdb1	794	16	Preclinical	preclinical	JJ
cord-295807-68sukdb1	794	17	update	update	NN
cord-295807-68sukdb1	794	18	on	on	IN
cord-295807-68sukdb1	794	19	regulation	regulation	NN
cord-295807-68sukdb1	794	20	of	of	IN
cord-295807-68sukdb1	794	21	intracranial	intracranial	JJ
cord-295807-68sukdb1	794	22	pressure	pressure	NN
cord-295807-68sukdb1	794	23	in	in	IN
cord-295807-68sukdb1	794	24	relation	relation	NN
cord-295807-68sukdb1	794	25	to	to	IN
cord-295807-68sukdb1	794	26	idiopathic	idiopathic	JJ
cord-295807-68sukdb1	794	27	intracranial	intracranial	JJ
cord-295807-68sukdb1	794	28	hypertension	hypertension	NN
cord-295807-68sukdb1	794	29	,	,	,
cord-295807-68sukdb1	794	30	Fluids	fluid	NNS
cord-295807-68sukdb1	794	31	and	and	CC
cord-295807-68sukdb1	794	32	Barriers	barrier	NNS
cord-295807-68sukdb1	794	33	of	of	IN
cord-295807-68sukdb1	794	34	the	the	DT
cord-295807-68sukdb1	794	35	CNS	CNS	NNP
cord-295807-68sukdb1	794	36	Studies	Studies	NNPS
cord-295807-68sukdb1	794	37	on	on	IN
cord-295807-68sukdb1	794	38	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	794	39	transporters	transporter	NNS
cord-295807-68sukdb1	794	40	and	and	CC
cord-295807-68sukdb1	794	41	carbonic	carbonic	JJ
cord-295807-68sukdb1	794	42	anhydrase	anhydrase	NN
cord-295807-68sukdb1	794	43	in	in	IN
cord-295807-68sukdb1	794	44	porcine	porcine	JJ
cord-295807-68sukdb1	794	45	nonpigmented	nonpigmented	JJ
cord-295807-68sukdb1	794	46	ciliary	ciliary	NN
cord-295807-68sukdb1	794	47	epithelium	epithelium	NN
cord-295807-68sukdb1	794	48	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	794	49	and	and	CC
cord-295807-68sukdb1	794	50	CI-/HCO3-antiporters	ci-/hco3-antiporter	NNS
cord-295807-68sukdb1	794	51	of	of	IN
cord-295807-68sukdb1	794	52	bovine	bovine	JJ
cord-295807-68sukdb1	794	53	pigmented	pigmented	JJ
cord-295807-68sukdb1	794	54	ciliary	ciliary	NN
cord-295807-68sukdb1	794	55	epithelial	epithelial	JJ
cord-295807-68sukdb1	794	56	cells	cell	NNS
cord-295807-68sukdb1	795	1	SLC4A11	slc4a11	CD
cord-295807-68sukdb1	795	2	and	and	CC
cord-295807-68sukdb1	795	3	the	the	DT
cord-295807-68sukdb1	795	4	Pathophysiology	Pathophysiology	NNP
cord-295807-68sukdb1	795	5	of	of	IN
cord-295807-68sukdb1	795	6	Congenital	Congenital	NNP
cord-295807-68sukdb1	795	7	Hereditary	hereditary	JJ
cord-295807-68sukdb1	795	8	Endothelial	endothelial	NN
cord-295807-68sukdb1	795	9	Dystrophy	Dystrophy	NNP
cord-295807-68sukdb1	795	10	H(OH	H(OH	NNP
cord-295807-68sukdb1	795	11	)	)	-RRB-
cord-295807-68sukdb1	796	1	:	:	:
cord-295807-68sukdb1	796	2	a	a	DT
cord-295807-68sukdb1	796	3	holiday	holiday	NN
cord-295807-68sukdb1	796	4	perspective	perspective	NN
cord-295807-68sukdb1	796	5	.	.	.
cord-295807-68sukdb1	797	1	Focus	focus	VB
cord-295807-68sukdb1	797	2	on	on	IN
cord-295807-68sukdb1	797	3	"	"	``
cord-295807-68sukdb1	797	4	Mouse	Mouse	NNP
cord-295807-68sukdb1	797	5	Slc4a11	Slc4a11	NNP
cord-295807-68sukdb1	797	6	expressed	express	VBD
cord-295807-68sukdb1	797	7	in	in	IN
cord-295807-68sukdb1	797	8	Xenopus	Xenopus	NNP
cord-295807-68sukdb1	797	9	oocytes	oocyte	NNS
cord-295807-68sukdb1	797	10	is	be	VBZ
cord-295807-68sukdb1	797	11	an	an	DT
cord-295807-68sukdb1	797	12	ideally	ideally	RB
cord-295807-68sukdb1	797	13	selective	selective	JJ
cord-295807-68sukdb1	797	14	H	h	NN
cord-295807-68sukdb1	797	15	+	+	CC
cord-295807-68sukdb1	798	1	/OH	/oh	CD
cord-295807-68sukdb1	798	2	-conductance	-conductance	NN
cord-295807-68sukdb1	798	3	pathway	pathway	NN
cord-295807-68sukdb1	798	4	that	that	WDT
cord-295807-68sukdb1	798	5	is	be	VBZ
cord-295807-68sukdb1	798	6	stimulated	stimulate	VBN
cord-295807-68sukdb1	798	7	by	by	IN
cord-295807-68sukdb1	798	8	rises	rise	NNS
cord-295807-68sukdb1	798	9	in	in	IN
cord-295807-68sukdb1	798	10	intracellular	intracellular	JJ
cord-295807-68sukdb1	798	11	and	and	CC
cord-295807-68sukdb1	798	12	extracellular	extracellular	JJ
cord-295807-68sukdb1	798	13	pH	ph	NN
cord-295807-68sukdb1	798	14	Functional	functional	JJ
cord-295807-68sukdb1	798	15	Roles	Roles	NNPS
cord-295807-68sukdb1	798	16	of	of	IN
cord-295807-68sukdb1	798	17	Electrogenic	Electrogenic	NNP
cord-295807-68sukdb1	798	18	Sodium	Sodium	NNP
cord-295807-68sukdb1	798	19	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	798	20	Cotransporter	Cotransporter	NNP
cord-295807-68sukdb1	798	21	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	798	22	in	in	IN
cord-295807-68sukdb1	798	23	Ocular	Ocular	NNP
cord-295807-68sukdb1	798	24	Tissues	Tissues	NNP
cord-295807-68sukdb1	798	25	Retinal	Retinal	NNP
cord-295807-68sukdb1	798	26	pH	ph	NN
cord-295807-68sukdb1	798	27	and	and	CC
cord-295807-68sukdb1	798	28	Acid	Acid	NNP
cord-295807-68sukdb1	798	29	Regulation	regulation	NN
cord-295807-68sukdb1	798	30	During	during	IN
cord-295807-68sukdb1	798	31	Metabolic	metabolic	JJ
cord-295807-68sukdb1	798	32	Acidosis	acidosis	NN
cord-295807-68sukdb1	798	33	Sources	source	NNS
cord-295807-68sukdb1	798	34	of	of	IN
cord-295807-68sukdb1	798	35	protons	proton	NNS
cord-295807-68sukdb1	798	36	and	and	CC
cord-295807-68sukdb1	798	37	a	a	DT
cord-295807-68sukdb1	798	38	role	role	NN
cord-295807-68sukdb1	798	39	for	for	IN
cord-295807-68sukdb1	798	40	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	798	41	in	in	IN
cord-295807-68sukdb1	798	42	inhibitory	inhibitory	JJ
cord-295807-68sukdb1	798	43	feedback	feedback	NN
cord-295807-68sukdb1	798	44	from	from	IN
cord-295807-68sukdb1	798	45	horizontal	horizontal	JJ
cord-295807-68sukdb1	798	46	cells	cell	NNS
cord-295807-68sukdb1	798	47	to	to	IN
cord-295807-68sukdb1	798	48	cones	cone	NNS
cord-295807-68sukdb1	798	49	in	in	IN
cord-295807-68sukdb1	798	50	Ambystoma	Ambystoma	NNP
cord-295807-68sukdb1	798	51	tigrinum	tigrinum	NNP
cord-295807-68sukdb1	799	1	retina	retina	NNP
cord-295807-68sukdb1	799	2	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	799	3	Modulates	modulate	VBZ
cord-295807-68sukdb1	799	4	Photoreceptor	Photoreceptor	NNP
cord-295807-68sukdb1	799	5	Guanylate	Guanylate	NNP
cord-295807-68sukdb1	799	6	Cyclase	Cyclase	NNP
cord-295807-68sukdb1	799	7	(	(	-LRB-
cord-295807-68sukdb1	799	8	ROS	ROS	NNP
cord-295807-68sukdb1	799	9	-	-	HYPH
cord-295807-68sukdb1	799	10	GC	GC	NNP
cord-295807-68sukdb1	799	11	)	)	-RRB-
cord-295807-68sukdb1	799	12	Catalytic	Catalytic	NNP
cord-295807-68sukdb1	799	13	Activity	Activity	NNP
cord-295807-68sukdb1	799	14	Novel	Novel	NNP
cord-295807-68sukdb1	799	15	mutation	mutation	NN
cord-295807-68sukdb1	799	16	in	in	IN
cord-295807-68sukdb1	799	17	SLC4A7	slc4a7	NN
cord-295807-68sukdb1	799	18	gene	gene	NN
cord-295807-68sukdb1	799	19	causing	cause	VBG
cord-295807-68sukdb1	799	20	autosomal	autosomal	JJ
cord-295807-68sukdb1	799	21	recessive	recessive	JJ
cord-295807-68sukdb1	799	22	progressive	progressive	JJ
cord-295807-68sukdb1	799	23	rod	rod	NN
cord-295807-68sukdb1	799	24	-	-	HYPH
cord-295807-68sukdb1	799	25	cone	cone	NN
cord-295807-68sukdb1	799	26	dystrophy	dystrophy	NN
cord-295807-68sukdb1	799	27	Severe	severe	JJ
cord-295807-68sukdb1	799	28	neurologic	neurologic	JJ
cord-295807-68sukdb1	799	29	impairment	impairment	NN
cord-295807-68sukdb1	799	30	in	in	IN
cord-295807-68sukdb1	799	31	mice	mouse	NNS
cord-295807-68sukdb1	799	32	with	with	IN
cord-295807-68sukdb1	799	33	targeted	target	VBN
cord-295807-68sukdb1	799	34	disruption	disruption	NN
cord-295807-68sukdb1	799	35	of	of	IN
cord-295807-68sukdb1	799	36	the	the	DT
cord-295807-68sukdb1	799	37	electrogenic	electrogenic	JJ
cord-295807-68sukdb1	799	38	sodium	sodium	NN
cord-295807-68sukdb1	799	39	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	800	1	cotransporter	cotransporter	NNP
cord-295807-68sukdb1	801	1	NBCe2	NBCe2	NNP
cord-295807-68sukdb1	801	2	(	(	-LRB-
cord-295807-68sukdb1	801	3	Slc4a5	slc4a5	NN
cord-295807-68sukdb1	801	4	gene	gene	NN
cord-295807-68sukdb1	801	5	)	)	-RRB-
cord-295807-68sukdb1	801	6	Role	role	NN
cord-295807-68sukdb1	801	7	of	of	IN
cord-295807-68sukdb1	801	8	monocarboxylate	monocarboxylate	NN
cord-295807-68sukdb1	801	9	transporters	transporter	NNS
cord-295807-68sukdb1	801	10	in	in	IN
cord-295807-68sukdb1	801	11	regulating	regulate	VBG
cord-295807-68sukdb1	801	12	metabolic	metabolic	JJ
cord-295807-68sukdb1	801	13	homeostasis	homeostasis	NN
cord-295807-68sukdb1	801	14	in	in	IN
cord-295807-68sukdb1	801	15	the	the	DT
cord-295807-68sukdb1	801	16	outer	outer	JJ
cord-295807-68sukdb1	801	17	retina	retina	NN
cord-295807-68sukdb1	801	18	:	:	:
cord-295807-68sukdb1	802	1	Insight	insight	NN
cord-295807-68sukdb1	802	2	gained	gain	VBD
cord-295807-68sukdb1	802	3	from	from	IN
cord-295807-68sukdb1	802	4	cell	cell	NN
cord-295807-68sukdb1	802	5	-	-	HYPH
cord-295807-68sukdb1	802	6	specific	specific	JJ
cord-295807-68sukdb1	802	7	Bsg	Bsg	NNP
cord-295807-68sukdb1	802	8	deletion	deletion	NN
cord-295807-68sukdb1	802	9	Genetics	genetic	NNS
cord-295807-68sukdb1	802	10	and	and	CC
cord-295807-68sukdb1	802	11	phenomics	phenomic	NNS
cord-295807-68sukdb1	802	12	of	of	IN
cord-295807-68sukdb1	802	13	Pendred	Pendred	NNP
cord-295807-68sukdb1	802	14	syndrome	syndrome	NN
cord-295807-68sukdb1	802	15	Novel	Novel	NNP
cord-295807-68sukdb1	802	16	ATP6V1B1	ATP6V1B1	NNP
cord-295807-68sukdb1	802	17	and	and	CC
cord-295807-68sukdb1	802	18	ATP6V0A4	ATP6V0A4	NNP
cord-295807-68sukdb1	802	19	mutations	mutation	NNS
cord-295807-68sukdb1	802	20	in	in	IN
cord-295807-68sukdb1	802	21	autosomal	autosomal	JJ
cord-295807-68sukdb1	802	22	recessive	recessive	JJ
cord-295807-68sukdb1	802	23	distal	distal	JJ
cord-295807-68sukdb1	802	24	renal	renal	JJ
cord-295807-68sukdb1	802	25	tubular	tubular	JJ
cord-295807-68sukdb1	802	26	acidosis	acidosis	NN
cord-295807-68sukdb1	802	27	with	with	IN
cord-295807-68sukdb1	802	28	new	new	JJ
cord-295807-68sukdb1	802	29	evidence	evidence	NN
cord-295807-68sukdb1	802	30	for	for	IN
cord-295807-68sukdb1	802	31	hearing	hear	VBG
cord-295807-68sukdb1	802	32	loss	loss	NN
cord-295807-68sukdb1	802	33	Congenital	congenital	JJ
cord-295807-68sukdb1	802	34	hereditary	hereditary	JJ
cord-295807-68sukdb1	802	35	endothelial	endothelial	JJ
cord-295807-68sukdb1	802	36	dystrophy	dystrophy	NN
cord-295807-68sukdb1	802	37	with	with	IN
cord-295807-68sukdb1	802	38	progressive	progressive	JJ
cord-295807-68sukdb1	802	39	sensorineural	sensorineural	JJ
cord-295807-68sukdb1	802	40	deafness	deafness	NN
cord-295807-68sukdb1	802	41	(	(	-LRB-
cord-295807-68sukdb1	802	42	Harboyan	Harboyan	NNP
cord-295807-68sukdb1	802	43	syndrome	syndrome	NN
cord-295807-68sukdb1	802	44	)	)	-RRB-
cord-295807-68sukdb1	803	1	Genetic	genetic	JJ
cord-295807-68sukdb1	803	2	disorders	disorder	NNS
cord-295807-68sukdb1	803	3	of	of	IN
cord-295807-68sukdb1	803	4	transporters	transporter	NNS
cord-295807-68sukdb1	803	5	/	/	SYM
cord-295807-68sukdb1	803	6	channels	channel	NNS
cord-295807-68sukdb1	803	7	in	in	IN
cord-295807-68sukdb1	803	8	the	the	DT
cord-295807-68sukdb1	803	9	inner	inner	JJ
cord-295807-68sukdb1	803	10	ear	ear	NN
cord-295807-68sukdb1	803	11	and	and	CC
cord-295807-68sukdb1	803	12	their	-PRON-	PRP$
cord-295807-68sukdb1	803	13	relation	relation	NN
cord-295807-68sukdb1	803	14	to	to	IN
cord-295807-68sukdb1	803	15	the	the	DT
cord-295807-68sukdb1	803	16	kidney	kidney	NN
cord-295807-68sukdb1	803	17	Early	early	RB
cord-295807-68sukdb1	803	18	Hearing	Hearing	NNP
cord-295807-68sukdb1	803	19	Loss	Loss	NNP
cord-295807-68sukdb1	803	20	upon	upon	IN
cord-295807-68sukdb1	803	21	Disruption	disruption	NN
cord-295807-68sukdb1	803	22	of	of	IN
cord-295807-68sukdb1	803	23	Slc4a10	Slc4a10	NNP
cord-295807-68sukdb1	803	24	in	in	IN
cord-295807-68sukdb1	803	25	C57BL/6	C57BL/6	NNP
cord-295807-68sukdb1	804	1	Mice	Mice	NNP
cord-295807-68sukdb1	804	2	Non	non	JJ
cord-295807-68sukdb1	804	3	-	-	JJ
cord-295807-68sukdb1	804	4	syndromic	syndromic	JJ
cord-295807-68sukdb1	804	5	vestibular	vestibular	JJ
cord-295807-68sukdb1	804	6	disorder	disorder	NN
cord-295807-68sukdb1	804	7	with	with	IN
cord-295807-68sukdb1	804	8	otoconial	otoconial	JJ
cord-295807-68sukdb1	804	9	agenesis	agenesis	NN
cord-295807-68sukdb1	804	10	in	in	IN
cord-295807-68sukdb1	804	11	tilted	tilted	NNP
cord-295807-68sukdb1	804	12	/	/	SYM
cord-295807-68sukdb1	804	13	mergulhador	mergulhador	NNP
cord-295807-68sukdb1	804	14	mice	mouse	NNS
cord-295807-68sukdb1	804	15	caused	cause	VBN
cord-295807-68sukdb1	804	16	by	by	IN
cord-295807-68sukdb1	804	17	mutations	mutation	NNS
cord-295807-68sukdb1	804	18	in	in	IN
cord-295807-68sukdb1	804	19	otopetrin	otopetrin	NN
cord-295807-68sukdb1	804	20	1	1	CD
cord-295807-68sukdb1	804	21	Calcium	calcium	NN
cord-295807-68sukdb1	804	22	oxalate	oxalate	NN
cord-295807-68sukdb1	804	23	stone	stone	NN
cord-295807-68sukdb1	804	24	formation	formation	NN
cord-295807-68sukdb1	804	25	in	in	IN
cord-295807-68sukdb1	804	26	the	the	DT
cord-295807-68sukdb1	804	27	inner	inner	JJ
cord-295807-68sukdb1	804	28	ear	ear	NN
cord-295807-68sukdb1	804	29	as	as	IN
cord-295807-68sukdb1	804	30	a	a	DT
cord-295807-68sukdb1	804	31	result	result	NN
cord-295807-68sukdb1	804	32	of	of	IN
cord-295807-68sukdb1	804	33	an	an	DT
cord-295807-68sukdb1	804	34	Slc26a4	slc26a4	NN
cord-295807-68sukdb1	804	35	mutation	mutation	NN
cord-295807-68sukdb1	804	36	Subcutaneous	Subcutaneous	NNP
cord-295807-68sukdb1	804	37	Injection	Injection	NNP
cord-295807-68sukdb1	804	38	of	of	IN
cord-295807-68sukdb1	804	39	Drugs	drug	NNS
cord-295807-68sukdb1	804	40	:	:	:
cord-295807-68sukdb1	804	41	Literature	literature	NN
cord-295807-68sukdb1	804	42	Review	Review	NNP
cord-295807-68sukdb1	804	43	of	of	IN
cord-295807-68sukdb1	804	44	Factors	factor	NNS
cord-295807-68sukdb1	804	45	Influencing	influence	VBG
cord-295807-68sukdb1	804	46	Pain	Pain	NNP
cord-295807-68sukdb1	804	47	Sensation	sensation	NN
cord-295807-68sukdb1	804	48	at	at	IN
cord-295807-68sukdb1	804	49	the	the	DT
cord-295807-68sukdb1	804	50	Injection	Injection	NNP
cord-295807-68sukdb1	804	51	Site	Site	NNP
cord-295807-68sukdb1	804	52	Loss	Loss	NNP
cord-295807-68sukdb1	804	53	of	of	IN
cord-295807-68sukdb1	804	54	SLC9A6	SLC9A6	NNP
cord-295807-68sukdb1	804	55	/	/	SYM
cord-295807-68sukdb1	804	56	NHE6	NHE6	NNP
cord-295807-68sukdb1	804	57	impairs	impair	VBZ
cord-295807-68sukdb1	804	58	nociception	nociception	NN
cord-295807-68sukdb1	804	59	in	in	IN
cord-295807-68sukdb1	804	60	a	a	DT
cord-295807-68sukdb1	804	61	mouse	mouse	NN
cord-295807-68sukdb1	804	62	model	model	NN
cord-295807-68sukdb1	804	63	of	of	IN
cord-295807-68sukdb1	804	64	Christianson	Christianson	NNP
cord-295807-68sukdb1	804	65	Syndrome	Syndrome	NNP
cord-295807-68sukdb1	804	66	Metabolic	metabolic	JJ
cord-295807-68sukdb1	804	67	acidosis	acidosis	NN
cord-295807-68sukdb1	804	68	and	and	CC
cord-295807-68sukdb1	804	69	anaemia	anaemia	NN
cord-295807-68sukdb1	804	70	associated	associate	VBN
cord-295807-68sukdb1	804	71	with	with	IN
cord-295807-68sukdb1	804	72	dorzolamide	dorzolamide	NN
cord-295807-68sukdb1	804	73	in	in	IN
cord-295807-68sukdb1	804	74	a	a	DT
cord-295807-68sukdb1	804	75	patient	patient	NN
cord-295807-68sukdb1	804	76	with	with	IN
cord-295807-68sukdb1	804	77	impaired	impaired	JJ
cord-295807-68sukdb1	804	78	renal	renal	JJ
cord-295807-68sukdb1	804	79	function	function	NN
cord-295807-68sukdb1	804	80	Metabolic	metabolic	JJ
cord-295807-68sukdb1	804	81	Acidosis	acidosis	NN
cord-295807-68sukdb1	804	82	with	with	IN
cord-295807-68sukdb1	804	83	Ophthalmic	Ophthalmic	NNP
cord-295807-68sukdb1	804	84	Dorzolamide	Dorzolamide	NNP
cord-295807-68sukdb1	804	85	in	in	IN
cord-295807-68sukdb1	804	86	a	a	DT
cord-295807-68sukdb1	804	87	Neonate	Neonate	NNP
cord-295807-68sukdb1	804	88	Ophthalmic	Ophthalmic	NNP
cord-295807-68sukdb1	804	89	Nonsteroidal	nonsteroidal	JJ
cord-295807-68sukdb1	804	90	Anti	anti	JJ
cord-295807-68sukdb1	804	91	-	-	JJ
cord-295807-68sukdb1	804	92	Inflammatory	inflammatory	JJ
cord-295807-68sukdb1	804	93	Drugs	drug	NNS
cord-295807-68sukdb1	804	94	as	as	IN
cord-295807-68sukdb1	804	95	a	a	DT
cord-295807-68sukdb1	804	96	Therapy	therapy	NN
cord-295807-68sukdb1	804	97	for	for	IN
cord-295807-68sukdb1	804	98	Corneal	Corneal	NNP
cord-295807-68sukdb1	804	99	Dystrophies	Dystrophies	NNPS
cord-295807-68sukdb1	804	100	Caused	cause	VBN
cord-295807-68sukdb1	804	101	by	by	IN
cord-295807-68sukdb1	804	102	SLC4A11	SLC4A11	NNP
cord-295807-68sukdb1	804	103	Mutation	Mutation	NNP
cord-295807-68sukdb1	804	104	Na+/H+-exchanger-1	Na+/H+-exchanger-1	NNP
cord-295807-68sukdb1	804	105	inhibition	inhibition	NN
cord-295807-68sukdb1	804	106	counteracts	counteract	VBZ
cord-295807-68sukdb1	804	107	diabetic	diabetic	JJ
cord-295807-68sukdb1	804	108	cataract	cataract	NN
cord-295807-68sukdb1	804	109	formation	formation	NN
cord-295807-68sukdb1	804	110	and	and	CC
cord-295807-68sukdb1	804	111	retinal	retinal	JJ
cord-295807-68sukdb1	804	112	oxidative	oxidative	JJ
cord-295807-68sukdb1	804	113	-	-	HYPH
cord-295807-68sukdb1	804	114	nitrative	nitrative	JJ
cord-295807-68sukdb1	804	115	stress	stress	NN
cord-295807-68sukdb1	804	116	and	and	CC
cord-295807-68sukdb1	804	117	apoptosis	apoptosis	NN
cord-295807-68sukdb1	804	118	Protective	protective	JJ
cord-295807-68sukdb1	804	119	effects	effect	NNS
cord-295807-68sukdb1	804	120	of	of	IN
cord-295807-68sukdb1	804	121	hypercapnic	hypercapnic	NNP
cord-295807-68sukdb1	804	122	acidosis	acidosis	NN
cord-295807-68sukdb1	804	123	on	on	IN
cord-295807-68sukdb1	804	124	Ischemia	ischemia	NN
cord-295807-68sukdb1	804	125	-	-	HYPH
cord-295807-68sukdb1	804	126	reperfusion	reperfusion	NN
cord-295807-68sukdb1	804	127	-	-	HYPH
cord-295807-68sukdb1	804	128	induced	induce	VBN
cord-295807-68sukdb1	804	129	retinal	retinal	JJ
cord-295807-68sukdb1	804	130	injury	injury	NN
cord-295807-68sukdb1	804	131	Cerumenolytic	Cerumenolytic	NNP
cord-295807-68sukdb1	804	132	Efficacy	Efficacy	NNP
cord-295807-68sukdb1	804	133	of	of	IN
cord-295807-68sukdb1	804	134	2.5	2.5	CD
cord-295807-68sukdb1	804	135	%	%	NN
cord-295807-68sukdb1	804	136	Sodium	sodium	NN
cord-295807-68sukdb1	804	137	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	804	138	Versus	Versus	NNP
cord-295807-68sukdb1	804	139	Docusate	Docusate	NNP
cord-295807-68sukdb1	804	140	Sodium	Sodium	NNP
cord-295807-68sukdb1	804	141	:	:	:
cord-295807-68sukdb1	805	1	A	a	DT
cord-295807-68sukdb1	805	2	Randomized	Randomized	NNP
cord-295807-68sukdb1	805	3	,	,	,
cord-295807-68sukdb1	805	4	Controlled	control	VBN
cord-295807-68sukdb1	805	5	Trial	trial	NN
cord-295807-68sukdb1	806	1	The	the	DT
cord-295807-68sukdb1	806	2	preparation	preparation	NN
cord-295807-68sukdb1	806	3	of	of	IN
cord-295807-68sukdb1	806	4	acetic	acetic	JJ
cord-295807-68sukdb1	806	5	acid	acid	NN
cord-295807-68sukdb1	806	6	for	for	IN
cord-295807-68sukdb1	806	7	use	use	NN
cord-295807-68sukdb1	806	8	in	in	IN
cord-295807-68sukdb1	806	9	otic	otic	JJ
cord-295807-68sukdb1	806	10	drops	drop	NNS
cord-295807-68sukdb1	806	11	and	and	CC
cord-295807-68sukdb1	806	12	its	-PRON-	PRP$
cord-295807-68sukdb1	806	13	effect	effect	NN
cord-295807-68sukdb1	806	14	on	on	IN
cord-295807-68sukdb1	806	15	endocochlear	endocochlear	JJ
cord-295807-68sukdb1	806	16	potential	potential	NN
cord-295807-68sukdb1	806	17	and	and	CC
cord-295807-68sukdb1	806	18	pH	ph	NN
cord-295807-68sukdb1	806	19	in	in	IN
cord-295807-68sukdb1	806	20	inner	inner	JJ
cord-295807-68sukdb1	806	21	ear	ear	NN
cord-295807-68sukdb1	806	22	fluid	fluid	NN
cord-295807-68sukdb1	806	23	Discovery	Discovery	NNP
cord-295807-68sukdb1	806	24	and	and	CC
cord-295807-68sukdb1	806	25	Development	Development	NNP
cord-295807-68sukdb1	806	26	of	of	IN
cord-295807-68sukdb1	806	27	S6821	S6821	NNP
cord-295807-68sukdb1	806	28	and	and	CC
cord-295807-68sukdb1	806	29	S7958	S7958	NNP
cord-295807-68sukdb1	806	30	as	as	IN
cord-295807-68sukdb1	806	31	Potent	Potent	NNP
cord-295807-68sukdb1	806	32	TAS2R8	TAS2R8	NNP
cord-295807-68sukdb1	806	33	Antagonists	Antagonists	NNP
cord-295807-68sukdb1	806	34	Modulation	Modulation	NNP
cord-295807-68sukdb1	806	35	of	of	IN
cord-295807-68sukdb1	806	36	Bitter	bitter	JJ
cord-295807-68sukdb1	806	37	Taste	Taste	NNP
cord-295807-68sukdb1	806	38	Perception	perception	NN
cord-295807-68sukdb1	806	39	by	by	IN
cord-295807-68sukdb1	806	40	a	a	DT
cord-295807-68sukdb1	806	41	Small	Small	NNP
cord-295807-68sukdb1	806	42	Molecule	Molecule	NNP
cord-295807-68sukdb1	806	43	hTAS2R	hTAS2R	VBD
cord-295807-68sukdb1	806	44	Antagonist	Antagonist	NNP
cord-295807-68sukdb1	806	45	Effect	Effect	NNP
cord-295807-68sukdb1	806	46	of	of	IN
cord-295807-68sukdb1	806	47	pH	ph	NN
cord-295807-68sukdb1	806	48	modification	modification	NN
cord-295807-68sukdb1	806	49	by	by	IN
cord-295807-68sukdb1	806	50	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	806	51	on	on	IN
cord-295807-68sukdb1	806	52	pain	pain	NN
cord-295807-68sukdb1	806	53	after	after	IN
cord-295807-68sukdb1	806	54	subcutaneous	subcutaneous	JJ
cord-295807-68sukdb1	806	55	lidocaine	lidocaine	NN
cord-295807-68sukdb1	806	56	injection	injection	NN
cord-295807-68sukdb1	806	57	Role	role	NN
cord-295807-68sukdb1	806	58	of	of	IN
cord-295807-68sukdb1	806	59	CFTR	CFTR	NNP
cord-295807-68sukdb1	806	60	in	in	IN
cord-295807-68sukdb1	806	61	epithelial	epithelial	JJ
cord-295807-68sukdb1	806	62	physiology	physiology	NN
cord-295807-68sukdb1	806	63	Pulmonary	pulmonary	JJ
cord-295807-68sukdb1	806	64	complications	complication	NNS
cord-295807-68sukdb1	806	65	of	of	IN
cord-295807-68sukdb1	806	66	cystic	cystic	JJ
cord-295807-68sukdb1	806	67	fibrosis	fibrosis	NN
cord-295807-68sukdb1	807	1	A	a	DT
cord-295807-68sukdb1	807	2	new	new	JJ
cord-295807-68sukdb1	807	3	role	role	NN
cord-295807-68sukdb1	807	4	for	for	IN
cord-295807-68sukdb1	807	5	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	807	6	in	in	IN
cord-295807-68sukdb1	807	7	mucus	mucus	NN
cord-295807-68sukdb1	807	8	formation	formation	NN
cord-295807-68sukdb1	808	1	Extracellular	Extracellular	NNP
cord-295807-68sukdb1	808	2	pH	ph	NN
cord-295807-68sukdb1	808	3	and	and	CC
cord-295807-68sukdb1	808	4	lung	lung	NN
cord-295807-68sukdb1	808	5	infections	infection	NNS
cord-295807-68sukdb1	808	6	in	in	IN
cord-295807-68sukdb1	808	7	cystic	cystic	JJ
cord-295807-68sukdb1	808	8	fibrosis	fibrosis	NN
cord-295807-68sukdb1	809	1	Airway	airway	JJ
cord-295807-68sukdb1	809	2	acidification	acidification	NN
cord-295807-68sukdb1	809	3	initiates	initiate	VBZ
cord-295807-68sukdb1	809	4	host	host	NN
cord-295807-68sukdb1	809	5	defense	defense	NN
cord-295807-68sukdb1	809	6	abnormalities	abnormality	NNS
cord-295807-68sukdb1	809	7	in	in	IN
cord-295807-68sukdb1	809	8	cystic	cystic	JJ
cord-295807-68sukdb1	809	9	fibrosis	fibrosis	NN
cord-295807-68sukdb1	809	10	mice	mouse	NNS
cord-295807-68sukdb1	809	11	Mechanisms	Mechanisms	NNPS
cord-295807-68sukdb1	809	12	of	of	IN
cord-295807-68sukdb1	809	13	Acid	Acid	NNP
cord-295807-68sukdb1	809	14	and	and	CC
cord-295807-68sukdb1	809	15	Base	Base	NNP
cord-295807-68sukdb1	809	16	Secretion	Secretion	NNP
cord-295807-68sukdb1	809	17	by	by	IN
cord-295807-68sukdb1	809	18	the	the	DT
cord-295807-68sukdb1	809	19	Airway	Airway	NNP
cord-295807-68sukdb1	809	20	Epithelium	Epithelium	NNP
cord-295807-68sukdb1	809	21	Airway	Airway	NNP
cord-295807-68sukdb1	809	22	pH	ph	NN
cord-295807-68sukdb1	809	23	homeostasis	homeostasis	NN
cord-295807-68sukdb1	809	24	in	in	IN
cord-295807-68sukdb1	809	25	asthma	asthma	NN
cord-295807-68sukdb1	809	26	and	and	CC
cord-295807-68sukdb1	809	27	other	other	JJ
cord-295807-68sukdb1	809	28	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	809	29	lung	lung	NN
cord-295807-68sukdb1	809	30	diseases	disease	NNS
cord-295807-68sukdb1	810	1	Hyperglycaemia	Hyperglycaemia	NNP
cord-295807-68sukdb1	810	2	and	and	CC
cord-295807-68sukdb1	810	3	Pseudomonas	Pseudomonas	NNP
cord-295807-68sukdb1	810	4	aeruginosa	aeruginosa	NN
cord-295807-68sukdb1	810	5	acidify	acidify	RB
cord-295807-68sukdb1	811	1	cystic	cystic	NNP
cord-295807-68sukdb1	811	2	fibrosis	fibrosis	NNP
cord-295807-68sukdb1	811	3	airway	airway	NN
cord-295807-68sukdb1	811	4	surface	surface	NN
cord-295807-68sukdb1	811	5	liquid	liquid	NN
cord-295807-68sukdb1	811	6	by	by	IN
cord-295807-68sukdb1	811	7	elevating	elevate	VBG
cord-295807-68sukdb1	811	8	epithelial	epithelial	JJ
cord-295807-68sukdb1	811	9	monocarboxylate	monocarboxylate	NN
cord-295807-68sukdb1	811	10	transporter	transporter	NN
cord-295807-68sukdb1	811	11	2	2	CD
cord-295807-68sukdb1	811	12	dependent	dependent	JJ
cord-295807-68sukdb1	811	13	lactate	lactate	NN
cord-295807-68sukdb1	811	14	-	-	HYPH
cord-295807-68sukdb1	811	15	H+	h+	NN
cord-295807-68sukdb1	811	16	secretion	secretion	NN
cord-295807-68sukdb1	812	1	CFTR	CFTR	NNP
cord-295807-68sukdb1	812	2	modulator	modulator	NN
cord-295807-68sukdb1	812	3	theratyping	theratyping	NN
cord-295807-68sukdb1	812	4	:	:	:
cord-295807-68sukdb1	813	1	Current	current	JJ
cord-295807-68sukdb1	813	2	status	status	NN
cord-295807-68sukdb1	813	3	,	,	,
cord-295807-68sukdb1	813	4	gaps	gap	NNS
cord-295807-68sukdb1	813	5	and	and	CC
cord-295807-68sukdb1	813	6	future	future	JJ
cord-295807-68sukdb1	813	7	directions	direction	NNS
cord-295807-68sukdb1	813	8	Rheological	Rheological	NNP
cord-295807-68sukdb1	813	9	Properties	Properties	NNPS
cord-295807-68sukdb1	813	10	of	of	IN
cord-295807-68sukdb1	813	11	Cystic	Cystic	NNP
cord-295807-68sukdb1	813	12	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	813	13	Bronchial	Bronchial	NNP
cord-295807-68sukdb1	813	14	Secretion	Secretion	NNP
cord-295807-68sukdb1	813	15	and	and	CC
cord-295807-68sukdb1	813	16	in	in	IN
cord-295807-68sukdb1	813	17	Vitro	Vitro	NNP
cord-295807-68sukdb1	813	18	Drug	Drug	NNP
cord-295807-68sukdb1	813	19	Permeation	Permeation	NNP
cord-295807-68sukdb1	813	20	Study	Study	NNP
cord-295807-68sukdb1	813	21	:	:	:
cord-295807-68sukdb1	813	22	The	the	DT
cord-295807-68sukdb1	813	23	Effect	Effect	NNP
cord-295807-68sukdb1	813	24	of	of	IN
cord-295807-68sukdb1	813	25	Sodium	Sodium	NNP
cord-295807-68sukdb1	813	26	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	813	27	Safety	Safety	NNP
cord-295807-68sukdb1	813	28	,	,	,
cord-295807-68sukdb1	813	29	Tolerability	Tolerability	NNP
cord-295807-68sukdb1	813	30	,	,	,
cord-295807-68sukdb1	813	31	and	and	CC
cord-295807-68sukdb1	813	32	Effects	effect	NNS
cord-295807-68sukdb1	813	33	of	of	IN
cord-295807-68sukdb1	813	34	Sodium	Sodium	NNP
cord-295807-68sukdb1	813	35	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	813	36	Inhalation	Inhalation	NNP
cord-295807-68sukdb1	813	37	in	in	IN
cord-295807-68sukdb1	813	38	Cystic	Cystic	NNP
cord-295807-68sukdb1	813	39	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	813	40	Repurposing	Repurposing	NNP
cord-295807-68sukdb1	813	41	tromethamine	tromethamine	NNP
cord-295807-68sukdb1	813	42	as	as	IN
cord-295807-68sukdb1	813	43	inhaled	inhale	VBN
cord-295807-68sukdb1	813	44	therapy	therapy	NN
cord-295807-68sukdb1	813	45	to	to	TO
cord-295807-68sukdb1	813	46	treat	treat	VB
cord-295807-68sukdb1	813	47	CF	CF	NNP
cord-295807-68sukdb1	813	48	airway	airway	NN
cord-295807-68sukdb1	813	49	disease	disease	NN
cord-295807-68sukdb1	814	1	Esomeprazole	Esomeprazole	NNP
cord-295807-68sukdb1	814	2	Increases	increase	VBZ
cord-295807-68sukdb1	814	3	Airway	Airway	NNP
cord-295807-68sukdb1	814	4	Surface	surface	NN
cord-295807-68sukdb1	814	5	Liquid	Liquid	NNP
cord-295807-68sukdb1	814	6	pH	ph	NN
cord-295807-68sukdb1	814	7	in	in	IN
cord-295807-68sukdb1	814	8	Primary	Primary	NNP
cord-295807-68sukdb1	814	9	Cystic	Cystic	NNP
cord-295807-68sukdb1	814	10	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	814	11	Epithelial	Epithelial	NNP
cord-295807-68sukdb1	814	12	Cells	Cells	NNPS
cord-295807-68sukdb1	814	13	Paracellular	Paracellular	NNP
cord-295807-68sukdb1	814	14	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	814	15	flux	flux	NN
cord-295807-68sukdb1	814	16	across	across	IN
cord-295807-68sukdb1	815	1	human	human	JJ
cord-295807-68sukdb1	815	2	cystic	cystic	NNP
cord-295807-68sukdb1	815	3	fibrosis	fibrosis	NNP
cord-295807-68sukdb1	815	4	airway	airway	NNP
cord-295807-68sukdb1	815	5	epithelia	epithelium	NNS
cord-295807-68sukdb1	815	6	tempers	temper	VBZ
cord-295807-68sukdb1	815	7	changes	change	NNS
cord-295807-68sukdb1	815	8	in	in	IN
cord-295807-68sukdb1	815	9	airway	airway	NN
cord-295807-68sukdb1	815	10	surface	surface	NN
cord-295807-68sukdb1	815	11	liquid	liquid	NN
cord-295807-68sukdb1	815	12	pH	pH	NNP
cord-295807-68sukdb1	815	13	Effects	effect	NNS
cord-295807-68sukdb1	815	14	of	of	IN
cord-295807-68sukdb1	815	15	changes	change	NNS
cord-295807-68sukdb1	815	16	of	of	IN
cord-295807-68sukdb1	815	17	pH	pH	NNP
cord-295807-68sukdb1	815	18	on	on	IN
cord-295807-68sukdb1	815	19	the	the	DT
cord-295807-68sukdb1	815	20	contractile	contractile	JJ
cord-295807-68sukdb1	815	21	function	function	NN
cord-295807-68sukdb1	815	22	of	of	IN
cord-295807-68sukdb1	815	23	cardiac	cardiac	JJ
cord-295807-68sukdb1	815	24	muscle	muscle	NN
cord-295807-68sukdb1	816	1	The	the	DT
cord-295807-68sukdb1	816	2	effects	effect	NNS
cord-295807-68sukdb1	816	3	of	of	IN
cord-295807-68sukdb1	816	4	acid	acid	NN
cord-295807-68sukdb1	816	5	-	-	HYPH
cord-295807-68sukdb1	816	6	base	base	NN
cord-295807-68sukdb1	816	7	disturbances	disturbance	NNS
cord-295807-68sukdb1	816	8	on	on	IN
cord-295807-68sukdb1	816	9	cardiovascular	cardiovascular	JJ
cord-295807-68sukdb1	816	10	and	and	CC
cord-295807-68sukdb1	816	11	pulmonary	pulmonary	JJ
cord-295807-68sukdb1	816	12	function	function	NN
cord-295807-68sukdb1	816	13	Relative	relative	JJ
cord-295807-68sukdb1	816	14	contributions	contribution	NNS
cord-295807-68sukdb1	816	15	of	of	IN
cord-295807-68sukdb1	816	16	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	816	17	exchange	exchange	NN
cord-295807-68sukdb1	816	18	and	and	CC
cord-295807-68sukdb1	816	19	Na+/HCO3-cotransport	na+/hco3-cotransport	NN
cord-295807-68sukdb1	816	20	to	to	IN
cord-295807-68sukdb1	816	21	ischemic	ischemic	JJ
cord-295807-68sukdb1	816	22	Nai+	nai+	CD
cord-295807-68sukdb1	816	23	overload	overload	NN
cord-295807-68sukdb1	816	24	in	in	IN
cord-295807-68sukdb1	816	25	isolated	isolate	VBN
cord-295807-68sukdb1	816	26	rat	rat	NN
cord-295807-68sukdb1	816	27	hearts	heart	NNS
cord-295807-68sukdb1	816	28	Impact	Impact	NNP
cord-295807-68sukdb1	816	29	of	of	IN
cord-295807-68sukdb1	816	30	systemic	systemic	JJ
cord-295807-68sukdb1	816	31	acidosis	acidosis	NN
cord-295807-68sukdb1	816	32	on	on	IN
cord-295807-68sukdb1	816	33	the	the	DT
cord-295807-68sukdb1	816	34	development	development	NN
cord-295807-68sukdb1	816	35	of	of	IN
cord-295807-68sukdb1	816	36	malignant	malignant	JJ
cord-295807-68sukdb1	816	37	ventricular	ventricular	JJ
cord-295807-68sukdb1	816	38	arrhythmias	arrhythmia	NNS
cord-295807-68sukdb1	816	39	after	after	IN
cord-295807-68sukdb1	816	40	reperfusion	reperfusion	NN
cord-295807-68sukdb1	816	41	therapy	therapy	NN
cord-295807-68sukdb1	816	42	for	for	IN
cord-295807-68sukdb1	816	43	ST	ST	NNP
cord-295807-68sukdb1	816	44	-	-	HYPH
cord-295807-68sukdb1	816	45	elevation	elevation	NNP
cord-295807-68sukdb1	816	46	myocardial	myocardial	JJ
cord-295807-68sukdb1	816	47	infarction	infarction	NN
cord-295807-68sukdb1	816	48	Mechanisms	mechanism	NNS
cord-295807-68sukdb1	816	49	Underlying	underlie	VBG
cord-295807-68sukdb1	816	50	the	the	DT
cord-295807-68sukdb1	816	51	Emergence	Emergence	NNP
cord-295807-68sukdb1	816	52	of	of	IN
cord-295807-68sukdb1	816	53	Post	Post	NNP
cord-295807-68sukdb1	816	54	-	-	JJ
cord-295807-68sukdb1	816	55	acidosis	acidosis	JJ
cord-295807-68sukdb1	816	56	Arrhythmia	arrhythmia	NN
cord-295807-68sukdb1	816	57	at	at	IN
cord-295807-68sukdb1	816	58	the	the	DT
cord-295807-68sukdb1	816	59	Tissue	tissue	NN
cord-295807-68sukdb1	816	60	Level	level	NN
cord-295807-68sukdb1	816	61	:	:	:
cord-295807-68sukdb1	817	1	A	a	DT
cord-295807-68sukdb1	817	2	Theoretical	theoretical	JJ
cord-295807-68sukdb1	817	3	Study	study	NN
cord-295807-68sukdb1	817	4	Reduced	reduce	VBN
cord-295807-68sukdb1	817	5	sarcolemmal	sarcolemmal	JJ
cord-295807-68sukdb1	817	6	expression	expression	NN
cord-295807-68sukdb1	817	7	and	and	CC
cord-295807-68sukdb1	817	8	function	function	NN
cord-295807-68sukdb1	817	9	of	of	IN
cord-295807-68sukdb1	817	10	the	the	DT
cord-295807-68sukdb1	817	11	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	817	12	isoform	isoform	NN
cord-295807-68sukdb1	817	13	of	of	IN
cord-295807-68sukdb1	817	14	the	the	DT
cord-295807-68sukdb1	817	15	Na	Na	NNP
cord-295807-68sukdb1	817	16	+	+	SYM
cord-295807-68sukdb1	817	17	-HCO₃	-HCO₃	NNS
cord-295807-68sukdb1	817	18	−	−	CD
cord-295807-68sukdb1	817	19	cotransporter	cotransporter	NN
cord-295807-68sukdb1	817	20	in	in	IN
cord-295807-68sukdb1	817	21	hypertrophied	hypertrophied	JJ
cord-295807-68sukdb1	817	22	cardiomyocytes	cardiomyocyte	NNS
cord-295807-68sukdb1	817	23	of	of	IN
cord-295807-68sukdb1	817	24	spontaneously	spontaneously	RB
cord-295807-68sukdb1	817	25	hypertensive	hypertensive	JJ
cord-295807-68sukdb1	817	26	rats	rat	NNS
cord-295807-68sukdb1	817	27	:	:	:
cord-295807-68sukdb1	817	28	role	role	NN
cord-295807-68sukdb1	817	29	of	of	IN
cord-295807-68sukdb1	817	30	the	the	DT
cord-295807-68sukdb1	817	31	reninangiotensin	reninangiotensin	NNP
cord-295807-68sukdb1	817	32	system	system	NN
cord-295807-68sukdb1	818	1	Carbonic	carbonic	JJ
cord-295807-68sukdb1	818	2	anhydrase	anhydrase	NN
cord-295807-68sukdb1	818	3	inhibition	inhibition	NN
cord-295807-68sukdb1	818	4	prevents	prevent	VBZ
cord-295807-68sukdb1	818	5	and	and	CC
cord-295807-68sukdb1	818	6	reverts	revert	VBZ
cord-295807-68sukdb1	818	7	cardiomyocyte	cardiomyocyte	NNP
cord-295807-68sukdb1	818	8	hypertrophy	hypertrophy	NN
cord-295807-68sukdb1	818	9	Loss	loss	NN
cord-295807-68sukdb1	818	10	of	of	IN
cord-295807-68sukdb1	818	11	the	the	DT
cord-295807-68sukdb1	818	12	AE3	AE3	NNP
cord-295807-68sukdb1	818	13	anion	anion	NN
cord-295807-68sukdb1	818	14	exchanger	exchanger	NN
cord-295807-68sukdb1	818	15	in	in	IN
cord-295807-68sukdb1	818	16	a	a	DT
cord-295807-68sukdb1	818	17	hypertrophic	hypertrophic	JJ
cord-295807-68sukdb1	818	18	cardiomyopathy	cardiomyopathy	NN
cord-295807-68sukdb1	818	19	model	model	NN
cord-295807-68sukdb1	819	1	causes	cause	VBZ
cord-295807-68sukdb1	819	2	rapid	rapid	JJ
cord-295807-68sukdb1	819	3	decompensation	decompensation	NN
cord-295807-68sukdb1	819	4	and	and	CC
cord-295807-68sukdb1	819	5	heart	heart	NN
cord-295807-68sukdb1	819	6	failure	failure	NN
cord-295807-68sukdb1	819	7	Mitochondrial	Mitochondrial	NNP
cord-295807-68sukdb1	819	8	NHE1	NHE1	NNP
cord-295807-68sukdb1	819	9	:	:	:
cord-295807-68sukdb1	819	10	a	a	DT
cord-295807-68sukdb1	819	11	newly	newly	RB
cord-295807-68sukdb1	819	12	identified	identify	VBN
cord-295807-68sukdb1	819	13	target	target	NN
cord-295807-68sukdb1	819	14	to	to	TO
cord-295807-68sukdb1	819	15	prevent	prevent	VB
cord-295807-68sukdb1	819	16	heart	heart	NN
cord-295807-68sukdb1	819	17	disease	disease	NN
cord-295807-68sukdb1	819	18	Disturbed	disturb	VBD
cord-295807-68sukdb1	819	19	acid	acid	NN
cord-295807-68sukdb1	819	20	-	-	HYPH
cord-295807-68sukdb1	819	21	base	base	NN
cord-295807-68sukdb1	819	22	transport	transport	NN
cord-295807-68sukdb1	819	23	:	:	:
cord-295807-68sukdb1	819	24	an	an	DT
cord-295807-68sukdb1	819	25	emerging	emerge	VBG
cord-295807-68sukdb1	819	26	cause	cause	NN
cord-295807-68sukdb1	819	27	of	of	IN
cord-295807-68sukdb1	819	28	hypertension	hypertension	NN
cord-295807-68sukdb1	820	1	Extracellular	extracellular	JJ
cord-295807-68sukdb1	820	2	acidosis	acidosis	NN
cord-295807-68sukdb1	820	3	suppresses	suppress	VBZ
cord-295807-68sukdb1	820	4	calcification	calcification	NN
cord-295807-68sukdb1	820	5	of	of	IN
cord-295807-68sukdb1	820	6	vascular	vascular	JJ
cord-295807-68sukdb1	820	7	smooth	smooth	JJ
cord-295807-68sukdb1	820	8	muscle	muscle	NN
cord-295807-68sukdb1	820	9	cells	cell	NNS
cord-295807-68sukdb1	820	10	by	by	IN
cord-295807-68sukdb1	820	11	inhibiting	inhibit	VBG
cord-295807-68sukdb1	820	12	calcium	calcium	NN
cord-295807-68sukdb1	820	13	influx	influx	NN
cord-295807-68sukdb1	820	14	via	via	IN
cord-295807-68sukdb1	820	15	Ltype	Ltype	NNP
cord-295807-68sukdb1	820	16	calcium	calcium	NN
cord-295807-68sukdb1	820	17	channels	channel	NNS
cord-295807-68sukdb1	820	18	Regulatory	regulatory	JJ
cord-295807-68sukdb1	820	19	mechanisms	mechanism	NNS
cord-295807-68sukdb1	820	20	of	of	IN
cord-295807-68sukdb1	820	21	hemoglobin	hemoglobin	NN
cord-295807-68sukdb1	820	22	oxygen	oxygen	NN
cord-295807-68sukdb1	820	23	affinity	affinity	NN
cord-295807-68sukdb1	820	24	in	in	IN
cord-295807-68sukdb1	820	25	acidosis	acidosis	NN
cord-295807-68sukdb1	820	26	and	and	CC
cord-295807-68sukdb1	820	27	alkalosis	alkalosis	NN
cord-295807-68sukdb1	820	28	Transgenic	transgenic	JJ
cord-295807-68sukdb1	820	29	expression	expression	NN
cord-295807-68sukdb1	820	30	of	of	IN
cord-295807-68sukdb1	820	31	carbonic	carbonic	JJ
cord-295807-68sukdb1	820	32	anhydrase	anhydrase	NN
cord-295807-68sukdb1	820	33	III	III	NNP
cord-295807-68sukdb1	820	34	in	in	IN
cord-295807-68sukdb1	820	35	cardiac	cardiac	JJ
cord-295807-68sukdb1	820	36	muscle	muscle	NN
cord-295807-68sukdb1	820	37	demonstrates	demonstrate	VBZ
cord-295807-68sukdb1	820	38	a	a	DT
cord-295807-68sukdb1	820	39	mechanism	mechanism	NN
cord-295807-68sukdb1	820	40	to	to	TO
cord-295807-68sukdb1	820	41	tolerate	tolerate	VB
cord-295807-68sukdb1	820	42	acidosis	acidosis	NN
cord-295807-68sukdb1	820	43	Sodium	sodium	NN
cord-295807-68sukdb1	820	44	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	820	45	on	on	IN
cord-295807-68sukdb1	820	46	severe	severe	JJ
cord-295807-68sukdb1	820	47	metabolic	metabolic	JJ
cord-295807-68sukdb1	820	48	acidosis	acidosis	NN
cord-295807-68sukdb1	820	49	during	during	IN
cord-295807-68sukdb1	820	50	prolonged	prolonged	JJ
cord-295807-68sukdb1	820	51	cardiopulmonary	cardiopulmonary	JJ
cord-295807-68sukdb1	820	52	resuscitation	resuscitation	NN
cord-295807-68sukdb1	820	53	:	:	:
cord-295807-68sukdb1	821	1	a	a	DT
cord-295807-68sukdb1	821	2	double	double	JJ
cord-295807-68sukdb1	821	3	-	-	HYPH
cord-295807-68sukdb1	821	4	blind	blind	JJ
cord-295807-68sukdb1	821	5	,	,	,
cord-295807-68sukdb1	821	6	randomized	randomized	JJ
cord-295807-68sukdb1	821	7	,	,	,
cord-295807-68sukdb1	821	8	placebo	placebo	NN
cord-295807-68sukdb1	821	9	-	-	HYPH
cord-295807-68sukdb1	821	10	controlled	control	VBN
cord-295807-68sukdb1	821	11	pilot	pilot	NN
cord-295807-68sukdb1	821	12	study	study	NN
cord-295807-68sukdb1	821	13	An	an	DT
cord-295807-68sukdb1	821	14	evidence	evidence	NN
cord-295807-68sukdb1	821	15	-	-	HYPH
cord-295807-68sukdb1	821	16	based	base	VBN
cord-295807-68sukdb1	821	17	evaluation	evaluation	NN
cord-295807-68sukdb1	821	18	of	of	IN
cord-295807-68sukdb1	821	19	the	the	DT
cord-295807-68sukdb1	821	20	use	use	NN
cord-295807-68sukdb1	821	21	of	of	IN
cord-295807-68sukdb1	821	22	sodium	sodium	NN
cord-295807-68sukdb1	821	23	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	821	24	during	during	IN
cord-295807-68sukdb1	821	25	cardiopulmonary	cardiopulmonary	JJ
cord-295807-68sukdb1	821	26	resuscitation	resuscitation	NN
cord-295807-68sukdb1	821	27	Sodium	sodium	NN
cord-295807-68sukdb1	821	28	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	821	29	:	:	:
cord-295807-68sukdb1	821	30	basically	basically	RB
cord-295807-68sukdb1	821	31	useless	useless	JJ
cord-295807-68sukdb1	821	32	therapy	therapy	NN
cord-295807-68sukdb1	821	33	NHE-1	NHE-1	NNP
cord-295807-68sukdb1	821	34	:	:	:
cord-295807-68sukdb1	821	35	still	still	RB
cord-295807-68sukdb1	821	36	a	a	DT
cord-295807-68sukdb1	821	37	viable	viable	JJ
cord-295807-68sukdb1	821	38	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	821	39	target	target	NN
cord-295807-68sukdb1	821	40	Cariporide	Cariporide	NNP
cord-295807-68sukdb1	821	41	(	(	-LRB-
cord-295807-68sukdb1	821	42	HOE642	HOE642	NNP
cord-295807-68sukdb1	821	43	)	)	-RRB-
cord-295807-68sukdb1	821	44	,	,	,
cord-295807-68sukdb1	821	45	a	a	DT
cord-295807-68sukdb1	821	46	selective	selective	JJ
cord-295807-68sukdb1	821	47	Na+-H+	na+-h+	CD
cord-295807-68sukdb1	821	48	exchange	exchange	NN
cord-295807-68sukdb1	821	49	inhibitor	inhibitor	NN
cord-295807-68sukdb1	821	50	,	,	,
cord-295807-68sukdb1	821	51	inhibits	inhibit	VBZ
cord-295807-68sukdb1	821	52	the	the	DT
cord-295807-68sukdb1	821	53	mitochondrial	mitochondrial	JJ
cord-295807-68sukdb1	821	54	death	death	NN
cord-295807-68sukdb1	821	55	pathway	pathway	NN
cord-295807-68sukdb1	822	1	Na+/H+	na+/h+	IN
cord-295807-68sukdb1	822	2	exchanger	exchanger	NN
cord-295807-68sukdb1	822	3	inhibitor	inhibitor	NN
cord-295807-68sukdb1	822	4	cariporide	cariporide	NNP
cord-295807-68sukdb1	822	5	attenuates	attenuate	VBZ
cord-295807-68sukdb1	822	6	the	the	DT
cord-295807-68sukdb1	822	7	mitochondrial	mitochondrial	NN
cord-295807-68sukdb1	822	8	Ca2	ca2	CD
cord-295807-68sukdb1	822	9	+	+	CC
cord-295807-68sukdb1	822	10	overload	overload	NN
cord-295807-68sukdb1	822	11	and	and	CC
cord-295807-68sukdb1	822	12	PTP	PTP	NNP
cord-295807-68sukdb1	822	13	opening	opening	NN
cord-295807-68sukdb1	823	1	inhibits	inhibit	VBZ
cord-295807-68sukdb1	823	2	endoplasmic	endoplasmic	NN
cord-295807-68sukdb1	823	3	reticulum	reticulum	NN
cord-295807-68sukdb1	823	4	stress	stress	NN
cord-295807-68sukdb1	823	5	-	-	HYPH
cord-295807-68sukdb1	823	6	induced	induce	VBN
cord-295807-68sukdb1	823	7	apoptosis	apoptosis	NN
cord-295807-68sukdb1	823	8	by	by	IN
cord-295807-68sukdb1	823	9	targeting	target	VBG
cord-295807-68sukdb1	823	10	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	823	11	exchanger-1	exchanger-1	NNP
cord-295807-68sukdb1	823	12	in	in	IN
cord-295807-68sukdb1	823	13	the	the	DT
cord-295807-68sukdb1	823	14	heart	heart	NN
cord-295807-68sukdb1	824	1	Inhibition	inhibition	NN
cord-295807-68sukdb1	824	2	of	of	IN
cord-295807-68sukdb1	824	3	the	the	DT
cord-295807-68sukdb1	824	4	cardiac	cardiac	JJ
cord-295807-68sukdb1	824	5	electrogenic	electrogenic	JJ
cord-295807-68sukdb1	824	6	sodium	sodium	NN
cord-295807-68sukdb1	824	7	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	824	8	cotransporter	cotransporter	NNP
cord-295807-68sukdb1	824	9	reduces	reduce	VBZ
cord-295807-68sukdb1	824	10	ischemic	ischemic	JJ
cord-295807-68sukdb1	824	11	injury	injury	NN
cord-295807-68sukdb1	824	12	Antibodies	Antibodies	NNP
cord-295807-68sukdb1	824	13	against	against	IN
cord-295807-68sukdb1	824	14	the	the	DT
cord-295807-68sukdb1	824	15	cardiac	cardiac	JJ
cord-295807-68sukdb1	824	16	sodium	sodium	NN
cord-295807-68sukdb1	824	17	/	/	SYM
cord-295807-68sukdb1	824	18	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	824	19	co	co	NN
cord-295807-68sukdb1	824	20	-	-	NN
cord-295807-68sukdb1	824	21	transporter	transporter	NN
cord-295807-68sukdb1	824	22	(	(	-LRB-
cord-295807-68sukdb1	824	23	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	824	24	)	)	-RRB-
cord-295807-68sukdb1	824	25	as	as	IN
cord-295807-68sukdb1	824	26	pharmacological	pharmacological	JJ
cord-295807-68sukdb1	824	27	tools	tool	NNS
cord-295807-68sukdb1	824	28	Sasanquasaponin	Sasanquasaponin	NNP
cord-295807-68sukdb1	824	29	induces	induce	VBZ
cord-295807-68sukdb1	824	30	increase	increase	NN
cord-295807-68sukdb1	824	31	of	of	IN
cord-295807-68sukdb1	824	32	Cl-/HCO3-exchange	cl-/hco3-exchange	NN
cord-295807-68sukdb1	824	33	of	of	IN
cord-295807-68sukdb1	824	34	anion	anion	NN
cord-295807-68sukdb1	824	35	exchanger	exchanger	NN
cord-295807-68sukdb1	824	36	3	3	CD
cord-295807-68sukdb1	824	37	and	and	CC
cord-295807-68sukdb1	824	38	promotes	promote	VBZ
cord-295807-68sukdb1	824	39	intracellular	intracellular	JJ
cord-295807-68sukdb1	824	40	Cl	Cl	NNP
cord-295807-68sukdb1	824	41	-	-	HYPH
cord-295807-68sukdb1	824	42	efflux	efflux	NN
cord-295807-68sukdb1	824	43	in	in	IN
cord-295807-68sukdb1	824	44	hypoxia	hypoxia	NN
cord-295807-68sukdb1	824	45	/	/	SYM
cord-295807-68sukdb1	824	46	reoxygenation	reoxygenation	NN
cord-295807-68sukdb1	824	47	cardiomyocytes	cardiomyocyte	NNS
cord-295807-68sukdb1	824	48	Bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	824	49	therapy	therapy	NN
cord-295807-68sukdb1	824	50	,	,	,
cord-295807-68sukdb1	824	51	phosphate	phosphate	NN
cord-295807-68sukdb1	824	52	binders	binder	NNS
cord-295807-68sukdb1	824	53	,	,	,
cord-295807-68sukdb1	824	54	and	and	CC
cord-295807-68sukdb1	824	55	risk	risk	NN
cord-295807-68sukdb1	824	56	for	for	IN
cord-295807-68sukdb1	824	57	vascular	vascular	JJ
cord-295807-68sukdb1	824	58	calcification	calcification	NN
cord-295807-68sukdb1	825	1	Hyperphosphatemic	Hyperphosphatemic	NNP
cord-295807-68sukdb1	825	2	familial	familial	JJ
cord-295807-68sukdb1	825	3	tumoral	tumoral	NNP
cord-295807-68sukdb1	825	4	calcinosis	calcinosis	NNP
cord-295807-68sukdb1	825	5	:	:	:
cord-295807-68sukdb1	826	1	response	response	NN
cord-295807-68sukdb1	826	2	to	to	IN
cord-295807-68sukdb1	826	3	acetazolamide	acetazolamide	NNP
cord-295807-68sukdb1	826	4	and	and	CC
cord-295807-68sukdb1	826	5	postulated	postulate	VBN
cord-295807-68sukdb1	826	6	mechanisms	mechanism	NNS
cord-295807-68sukdb1	826	7	Metabolic	metabolic	JJ
cord-295807-68sukdb1	826	8	and	and	CC
cord-295807-68sukdb1	826	9	hemodynamic	hemodynamic	JJ
cord-295807-68sukdb1	826	10	consequences	consequence	NNS
cord-295807-68sukdb1	826	11	of	of	IN
cord-295807-68sukdb1	826	12	sodium	sodium	NN
cord-295807-68sukdb1	826	13	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	826	14	administration	administration	NN
cord-295807-68sukdb1	826	15	in	in	IN
cord-295807-68sukdb1	826	16	patients	patient	NNS
cord-295807-68sukdb1	826	17	with	with	IN
cord-295807-68sukdb1	826	18	heart	heart	NN
cord-295807-68sukdb1	826	19	disease	disease	NN
cord-295807-68sukdb1	826	20	Cellular	cellular	JJ
cord-295807-68sukdb1	826	21	mechanisms	mechanism	NNS
cord-295807-68sukdb1	826	22	of	of	IN
cord-295807-68sukdb1	826	23	muscle	muscle	NN
cord-295807-68sukdb1	826	24	fatigue	fatigue	NN
cord-295807-68sukdb1	826	25	Challenging	challenge	VBG
cord-295807-68sukdb1	826	26	the	the	DT
cord-295807-68sukdb1	826	27	role	role	NN
cord-295807-68sukdb1	826	28	of	of	IN
cord-295807-68sukdb1	826	29	pH	ph	NN
cord-295807-68sukdb1	826	30	in	in	IN
cord-295807-68sukdb1	826	31	skeletal	skeletal	JJ
cord-295807-68sukdb1	826	32	muscle	muscle	NN
cord-295807-68sukdb1	826	33	fatigue	fatigue	NN
cord-295807-68sukdb1	826	34	Lactic	lactic	JJ
cord-295807-68sukdb1	826	35	acid	acid	NN
cord-295807-68sukdb1	826	36	and	and	CC
cord-295807-68sukdb1	826	37	exercise	exercise	NN
cord-295807-68sukdb1	826	38	performance	performance	NN
cord-295807-68sukdb1	826	39	:	:	:
cord-295807-68sukdb1	826	40	culprit	culprit	NN
cord-295807-68sukdb1	826	41	or	or	CC
cord-295807-68sukdb1	826	42	friend	friend	NN
cord-295807-68sukdb1	826	43	?	?	.
cord-295807-68sukdb1	827	1	K+	K+	NNP
cord-295807-68sukdb1	827	2	and	and	CC
cord-295807-68sukdb1	827	3	Lac	Lac	NNP
cord-295807-68sukdb1	827	4	-	-	HYPH
cord-295807-68sukdb1	827	5	distribution	distribution	NN
cord-295807-68sukdb1	827	6	in	in	IN
cord-295807-68sukdb1	827	7	humans	human	NNS
cord-295807-68sukdb1	827	8	during	during	IN
cord-295807-68sukdb1	827	9	and	and	CC
cord-295807-68sukdb1	827	10	after	after	IN
cord-295807-68sukdb1	827	11	high	high	JJ
cord-295807-68sukdb1	827	12	-	-	HYPH
cord-295807-68sukdb1	827	13	intensity	intensity	NN
cord-295807-68sukdb1	827	14	exercise	exercise	NN
cord-295807-68sukdb1	827	15	:	:	:
cord-295807-68sukdb1	827	16	role	role	NN
cord-295807-68sukdb1	827	17	in	in	IN
cord-295807-68sukdb1	827	18	muscle	muscle	NN
cord-295807-68sukdb1	827	19	fatigue	fatigue	NN
cord-295807-68sukdb1	827	20	attenuation	attenuation	NN
cord-295807-68sukdb1	827	21	?	?	.
cord-295807-68sukdb1	828	1	Metabolic	metabolic	JJ
cord-295807-68sukdb1	828	2	and	and	CC
cord-295807-68sukdb1	828	3	clinical	clinical	JJ
cord-295807-68sukdb1	828	4	consequences	consequence	NNS
cord-295807-68sukdb1	828	5	of	of	IN
cord-295807-68sukdb1	828	6	metabolic	metabolic	JJ
cord-295807-68sukdb1	828	7	acidosis	acidosis	NN
cord-295807-68sukdb1	828	8	Three	three	CD
cord-295807-68sukdb1	828	9	-	-	HYPH
cord-295807-68sukdb1	828	10	generation	generation	NN
cord-295807-68sukdb1	828	11	Study	Study	NNP
cord-295807-68sukdb1	828	12	of	of	IN
cord-295807-68sukdb1	828	13	Women	Women	NNPS
cord-295807-68sukdb1	828	14	on	on	IN
cord-295807-68sukdb1	828	15	Diets	Diets	NNPS
cord-295807-68sukdb1	828	16	and	and	CC
cord-295807-68sukdb1	828	17	Health	Health	NNP
cord-295807-68sukdb1	828	18	Study	Study	NNP
cord-295807-68sukdb1	828	19	Group	Group	NNP
cord-295807-68sukdb1	828	20	,	,	,
cord-295807-68sukdb1	828	21	Higher	high	JJR
cord-295807-68sukdb1	828	22	dietary	dietary	JJ
cord-295807-68sukdb1	828	23	acid	acid	NN
cord-295807-68sukdb1	828	24	load	load	NN
cord-295807-68sukdb1	828	25	is	be	VBZ
cord-295807-68sukdb1	828	26	associated	associate	VBN
cord-295807-68sukdb1	828	27	with	with	IN
cord-295807-68sukdb1	828	28	a	a	DT
cord-295807-68sukdb1	828	29	higher	high	JJR
cord-295807-68sukdb1	828	30	prevalence	prevalence	NN
cord-295807-68sukdb1	828	31	of	of	IN
cord-295807-68sukdb1	828	32	frailty	frailty	NN
cord-295807-68sukdb1	828	33	,	,	,
cord-295807-68sukdb1	828	34	particularly	particularly	RB
cord-295807-68sukdb1	828	35	slowness	slowness	NN
cord-295807-68sukdb1	828	36	/	/	SYM
cord-295807-68sukdb1	828	37	weakness	weakness	NN
cord-295807-68sukdb1	828	38	and	and	CC
cord-295807-68sukdb1	828	39	low	low	JJ
cord-295807-68sukdb1	828	40	physical	physical	JJ
cord-295807-68sukdb1	828	41	activity	activity	NN
cord-295807-68sukdb1	828	42	,	,	,
cord-295807-68sukdb1	828	43	in	in	IN
cord-295807-68sukdb1	828	44	elderly	elderly	JJ
cord-295807-68sukdb1	828	45	Japanese	japanese	JJ
cord-295807-68sukdb1	828	46	women	woman	NNS
cord-295807-68sukdb1	828	47	Regulation	regulation	NN
cord-295807-68sukdb1	828	48	of	of	IN
cord-295807-68sukdb1	828	49	pH	pH	NNP
cord-295807-68sukdb1	828	50	in	in	IN
cord-295807-68sukdb1	828	51	human	human	JJ
cord-295807-68sukdb1	828	52	skeletal	skeletal	JJ
cord-295807-68sukdb1	828	53	muscle	muscle	NN
cord-295807-68sukdb1	828	54	:	:	:
cord-295807-68sukdb1	828	55	adaptations	adaptation	NNS
cord-295807-68sukdb1	828	56	to	to	IN
cord-295807-68sukdb1	828	57	physical	physical	JJ
cord-295807-68sukdb1	828	58	activity	activity	NN
cord-295807-68sukdb1	829	1	Carbonic	carbonic	JJ
cord-295807-68sukdb1	829	2	Anhydrase	Anhydrase	NNP
cord-295807-68sukdb1	829	3	III	III	NNP
cord-295807-68sukdb1	829	4	Is	be	VBZ
cord-295807-68sukdb1	829	5	Expressed	express	VBN
cord-295807-68sukdb1	829	6	in	in	IN
cord-295807-68sukdb1	829	7	Mouse	mouse	NN
cord-295807-68sukdb1	829	8	Skeletal	skeletal	JJ
cord-295807-68sukdb1	829	9	Muscles	Muscles	NNPS
cord-295807-68sukdb1	829	10	Independent	Independent	NNP
cord-295807-68sukdb1	829	11	of	of	IN
cord-295807-68sukdb1	829	12	Fiber	Fiber	NNP
cord-295807-68sukdb1	829	13	Type	type	NN
cord-295807-68sukdb1	829	14	-	-	HYPH
cord-295807-68sukdb1	829	15	Specific	specific	JJ
cord-295807-68sukdb1	829	16	Myofilament	Myofilament	NNP
cord-295807-68sukdb1	829	17	Protein	Protein	NNP
cord-295807-68sukdb1	829	18	Isoforms	Isoforms	NNPS
cord-295807-68sukdb1	829	19	and	and	CC
cord-295807-68sukdb1	829	20	Plays	play	VBZ
cord-295807-68sukdb1	829	21	a	a	DT
cord-295807-68sukdb1	829	22	Role	role	NN
cord-295807-68sukdb1	829	23	in	in	IN
cord-295807-68sukdb1	829	24	Fatigue	Fatigue	NNP
cord-295807-68sukdb1	829	25	Resistance	Resistance	NNP
cord-295807-68sukdb1	829	26	Effects	effect	NNS
cord-295807-68sukdb1	829	27	of	of	IN
cord-295807-68sukdb1	829	28	Sodium	Sodium	NNP
cord-295807-68sukdb1	829	29	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	829	30	on	on	IN
cord-295807-68sukdb1	829	31	High	high	JJ
cord-295807-68sukdb1	829	32	-	-	HYPH
cord-295807-68sukdb1	829	33	Intensity	intensity	NN
cord-295807-68sukdb1	829	34	Endurance	Endurance	NNP
cord-295807-68sukdb1	829	35	Performance	performance	NN
cord-295807-68sukdb1	829	36	in	in	IN
cord-295807-68sukdb1	829	37	Cyclists	cyclist	NNS
cord-295807-68sukdb1	829	38	:	:	:
cord-295807-68sukdb1	830	1	A	a	DT
cord-295807-68sukdb1	830	2	Double	double	JJ
cord-295807-68sukdb1	830	3	-	-	HYPH
cord-295807-68sukdb1	830	4	Blind	blind	JJ
cord-295807-68sukdb1	830	5	,	,	,
cord-295807-68sukdb1	830	6	Randomized	Randomized	NNP
cord-295807-68sukdb1	830	7	Cross	Cross	NNP
cord-295807-68sukdb1	830	8	-	-	HYPH
cord-295807-68sukdb1	830	9	Over	Over	NNP
cord-295807-68sukdb1	830	10	Trial	Trial	NNP
cord-295807-68sukdb1	830	11	Sodium	Sodium	NNP
cord-295807-68sukdb1	830	12	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	830	13	supplementation	supplementation	NN
cord-295807-68sukdb1	830	14	does	do	VBZ
cord-295807-68sukdb1	830	15	not	not	RB
cord-295807-68sukdb1	830	16	improve	improve	VB
cord-295807-68sukdb1	830	17	elite	elite	JJ
cord-295807-68sukdb1	830	18	women	woman	NNS
cord-295807-68sukdb1	830	19	's	's	POS
cord-295807-68sukdb1	830	20	team	team	NN
cord-295807-68sukdb1	830	21	sport	sport	NN
cord-295807-68sukdb1	830	22	running	running	NN
cord-295807-68sukdb1	830	23	or	or	CC
cord-295807-68sukdb1	830	24	field	field	NN
cord-295807-68sukdb1	830	25	hockey	hockey	NN
cord-295807-68sukdb1	830	26	skill	skill	NN
cord-295807-68sukdb1	830	27	performance	performance	NN
cord-295807-68sukdb1	831	1	The	the	DT
cord-295807-68sukdb1	831	2	Impact	Impact	NNP
cord-295807-68sukdb1	831	3	of	of	IN
cord-295807-68sukdb1	831	4	Sodium	Sodium	NNP
cord-295807-68sukdb1	831	5	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	831	6	on	on	IN
cord-295807-68sukdb1	831	7	Performance	Performance	NNP
cord-295807-68sukdb1	831	8	in	in	IN
cord-295807-68sukdb1	831	9	Response	response	NN
cord-295807-68sukdb1	831	10	to	to	IN
cord-295807-68sukdb1	831	11	Exercise	exercise	VB
cord-295807-68sukdb1	831	12	Duration	duration	NN
cord-295807-68sukdb1	831	13	in	in	IN
cord-295807-68sukdb1	831	14	Athletes	athlete	NNS
cord-295807-68sukdb1	831	15	:	:	:
cord-295807-68sukdb1	831	16	A	a	DT
cord-295807-68sukdb1	831	17	Systematic	systematic	JJ
cord-295807-68sukdb1	831	18	Review	Review	NNP
cord-295807-68sukdb1	831	19	Mechanistic	mechanistic	JJ
cord-295807-68sukdb1	831	20	Insights	Insights	NNPS
cord-295807-68sukdb1	831	21	into	into	IN
cord-295807-68sukdb1	831	22	the	the	DT
cord-295807-68sukdb1	831	23	Efficacy	Efficacy	NNP
cord-295807-68sukdb1	831	24	of	of	IN
cord-295807-68sukdb1	831	25	Sodium	Sodium	NNP
cord-295807-68sukdb1	831	26	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	831	27	Supplementation	Supplementation	NNP
cord-295807-68sukdb1	831	28	to	to	TO
cord-295807-68sukdb1	831	29	Improve	improve	VB
cord-295807-68sukdb1	831	30	Athletic	Athletic	NNP
cord-295807-68sukdb1	831	31	Performance	Performance	NNP
cord-295807-68sukdb1	831	32	Effect	Effect	NNP
cord-295807-68sukdb1	831	33	of	of	IN
cord-295807-68sukdb1	831	34	sodium	sodium	NN
cord-295807-68sukdb1	831	35	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	831	36	on	on	IN
cord-295807-68sukdb1	831	37	prolonged	prolong	VBN
cord-295807-68sukdb1	831	38	running	running	NN
cord-295807-68sukdb1	831	39	performance	performance	NN
cord-295807-68sukdb1	832	1	:	:	:
cord-295807-68sukdb1	832	2	A	a	DT
cord-295807-68sukdb1	832	3	randomized	randomized	JJ
cord-295807-68sukdb1	832	4	,	,	,
cord-295807-68sukdb1	832	5	double	double	JJ
cord-295807-68sukdb1	832	6	-	-	HYPH
cord-295807-68sukdb1	832	7	blind	blind	JJ
cord-295807-68sukdb1	832	8	,	,	,
cord-295807-68sukdb1	832	9	cross	cross	JJ
cord-295807-68sukdb1	832	10	-	-	HYPH
cord-295807-68sukdb1	832	11	over	over	RP
cord-295807-68sukdb1	832	12	study	study	NN
cord-295807-68sukdb1	832	13	Potassium	potassium	NN
cord-295807-68sukdb1	832	14	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	832	15	reduces	reduce	VBZ
cord-295807-68sukdb1	832	16	urinary	urinary	JJ
cord-295807-68sukdb1	832	17	nitrogen	nitrogen	NN
cord-295807-68sukdb1	832	18	excretion	excretion	NN
cord-295807-68sukdb1	832	19	in	in	IN
cord-295807-68sukdb1	832	20	postmenopausal	postmenopausal	JJ
cord-295807-68sukdb1	832	21	women	woman	NNS
cord-295807-68sukdb1	832	22	Dietary	dietary	JJ
cord-295807-68sukdb1	832	23	Patterns	Patterns	NNPS
cord-295807-68sukdb1	832	24	,	,	,
cord-295807-68sukdb1	832	25	Skeletal	Skeletal	NNP
cord-295807-68sukdb1	832	26	Muscle	Muscle	NNP
cord-295807-68sukdb1	832	27	Health	Health	NNP
cord-295807-68sukdb1	832	28	,	,	,
cord-295807-68sukdb1	832	29	and	and	CC
cord-295807-68sukdb1	832	30	Sarcopenia	Sarcopenia	NNP
cord-295807-68sukdb1	832	31	in	in	IN
cord-295807-68sukdb1	832	32	Older	old	JJR
cord-295807-68sukdb1	832	33	Adults	Adults	NNPS
cord-295807-68sukdb1	833	1	The	the	DT
cord-295807-68sukdb1	833	2	effects	effect	NNS
cord-295807-68sukdb1	833	3	of	of	IN
cord-295807-68sukdb1	833	4	acid	acid	NN
cord-295807-68sukdb1	833	5	on	on	IN
cord-295807-68sukdb1	833	6	bone	bone	NN
cord-295807-68sukdb1	833	7	Metabolic	metabolic	JJ
cord-295807-68sukdb1	833	8	acidosis	acidosis	NN
cord-295807-68sukdb1	833	9	inhibits	inhibit	VBZ
cord-295807-68sukdb1	833	10	growth	growth	NN
cord-295807-68sukdb1	833	11	hormone	hormone	NN
cord-295807-68sukdb1	833	12	secretion	secretion	NN
cord-295807-68sukdb1	833	13	in	in	IN
cord-295807-68sukdb1	833	14	rats	rat	NNS
cord-295807-68sukdb1	833	15	:	:	:
cord-295807-68sukdb1	833	16	mechanism	mechanism	NN
cord-295807-68sukdb1	833	17	of	of	IN
cord-295807-68sukdb1	833	18	growth	growth	NN
cord-295807-68sukdb1	833	19	retardation	retardation	NN
cord-295807-68sukdb1	833	20	Serum	serum	NN
cord-295807-68sukdb1	833	21	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	833	22	and	and	CC
cord-295807-68sukdb1	833	23	Bone	Bone	NNP
cord-295807-68sukdb1	833	24	Mineral	Mineral	NNP
cord-295807-68sukdb1	833	25	Density	Density	NNP
cord-295807-68sukdb1	833	26	in	in	IN
cord-295807-68sukdb1	833	27	US	US	NNP
cord-295807-68sukdb1	833	28	Adults	Adults	NNPS
cord-295807-68sukdb1	834	1	Acute	acute	JJ
cord-295807-68sukdb1	834	2	metabolic	metabolic	JJ
cord-295807-68sukdb1	834	3	acidosis	acidosis	NN
cord-295807-68sukdb1	834	4	enhances	enhance	VBZ
cord-295807-68sukdb1	834	5	circulating	circulate	VBG
cord-295807-68sukdb1	834	6	parathyroid	parathyroid	JJ
cord-295807-68sukdb1	834	7	hormone	hormone	NN
cord-295807-68sukdb1	834	8	,	,	,
cord-295807-68sukdb1	834	9	which	which	WDT
cord-295807-68sukdb1	834	10	contributes	contribute	VBZ
cord-295807-68sukdb1	834	11	to	to	IN
cord-295807-68sukdb1	834	12	the	the	DT
cord-295807-68sukdb1	834	13	renal	renal	JJ
cord-295807-68sukdb1	834	14	response	response	NN
cord-295807-68sukdb1	834	15	against	against	IN
cord-295807-68sukdb1	834	16	acidosis	acidosis	NN
cord-295807-68sukdb1	834	17	in	in	IN
cord-295807-68sukdb1	834	18	the	the	DT
cord-295807-68sukdb1	834	19	rat	rat	NN
cord-295807-68sukdb1	834	20	Defects	defect	NNS
cord-295807-68sukdb1	834	21	in	in	IN
cord-295807-68sukdb1	834	22	TCIRG1	tcirg1	CD
cord-295807-68sukdb1	834	23	subunit	subunit	NN
cord-295807-68sukdb1	834	24	of	of	IN
cord-295807-68sukdb1	834	25	the	the	DT
cord-295807-68sukdb1	834	26	vacuolar	vacuolar	JJ
cord-295807-68sukdb1	834	27	proton	proton	NN
cord-295807-68sukdb1	834	28	pump	pump	NN
cord-295807-68sukdb1	834	29	are	be	VBP
cord-295807-68sukdb1	834	30	responsible	responsible	JJ
cord-295807-68sukdb1	834	31	for	for	IN
cord-295807-68sukdb1	834	32	a	a	DT
cord-295807-68sukdb1	834	33	subset	subset	NN
cord-295807-68sukdb1	834	34	of	of	IN
cord-295807-68sukdb1	834	35	human	human	JJ
cord-295807-68sukdb1	834	36	autosomal	autosomal	JJ
cord-295807-68sukdb1	834	37	recessive	recessive	JJ
cord-295807-68sukdb1	834	38	osteopetrosis	osteopetrosis	NN
cord-295807-68sukdb1	834	39	Carbonic	Carbonic	NNP
cord-295807-68sukdb1	834	40	anhydrase	anhydrase	NN
cord-295807-68sukdb1	834	41	II	II	NNP
cord-295807-68sukdb1	834	42	deficiency	deficiency	NN
cord-295807-68sukdb1	834	43	in	in	IN
cord-295807-68sukdb1	834	44	12	12	CD
cord-295807-68sukdb1	834	45	families	family	NNS
cord-295807-68sukdb1	834	46	with	with	IN
cord-295807-68sukdb1	834	47	the	the	DT
cord-295807-68sukdb1	834	48	autosomal	autosomal	JJ
cord-295807-68sukdb1	834	49	recessive	recessive	JJ
cord-295807-68sukdb1	834	50	syndrome	syndrome	NN
cord-295807-68sukdb1	834	51	of	of	IN
cord-295807-68sukdb1	834	52	osteopetrosis	osteopetrosis	NNP
cord-295807-68sukdb1	834	53	with	with	IN
cord-295807-68sukdb1	834	54	renal	renal	JJ
cord-295807-68sukdb1	834	55	tubular	tubular	JJ
cord-295807-68sukdb1	834	56	acidosis	acidosis	NN
cord-295807-68sukdb1	834	57	and	and	CC
cord-295807-68sukdb1	834	58	cerebral	cerebral	JJ
cord-295807-68sukdb1	834	59	calcification	calcification	NN
cord-295807-68sukdb1	834	60	Mouse	Mouse	NNP
cord-295807-68sukdb1	834	61	Models	Models	NNPS
cord-295807-68sukdb1	834	62	of	of	IN
cord-295807-68sukdb1	834	63	SLC4-linked	SLC4-linked	NNP
cord-295807-68sukdb1	834	64	Disorders	disorder	NNS
cord-295807-68sukdb1	834	65	of	of	IN
cord-295807-68sukdb1	834	66	HCO3	HCO3	NNP
cord-295807-68sukdb1	834	67	-Transporter	-Transporter	.
cord-295807-68sukdb1	834	68	Dysfunction	Dysfunction	NNP
cord-295807-68sukdb1	834	69	Effect	Effect	NNP
cord-295807-68sukdb1	834	70	of	of	IN
cord-295807-68sukdb1	834	71	chronic	chronic	JJ
cord-295807-68sukdb1	834	72	carbonic	carbonic	JJ
cord-295807-68sukdb1	834	73	anhydrase	anhydrase	NN
cord-295807-68sukdb1	834	74	inhibitor	inhibitor	NN
cord-295807-68sukdb1	834	75	therapy	therapy	NN
cord-295807-68sukdb1	834	76	on	on	IN
cord-295807-68sukdb1	834	77	bone	bone	NN
cord-295807-68sukdb1	834	78	mineral	mineral	NN
cord-295807-68sukdb1	834	79	density	density	NN
cord-295807-68sukdb1	834	80	in	in	IN
cord-295807-68sukdb1	834	81	white	white	JJ
cord-295807-68sukdb1	834	82	women	woman	NNS
cord-295807-68sukdb1	834	83	Can	Can	MD
cord-295807-68sukdb1	834	84	acetazolamide	acetazolamide	VB
cord-295807-68sukdb1	834	85	be	be	VB
cord-295807-68sukdb1	834	86	used	use	VBN
cord-295807-68sukdb1	834	87	to	to	TO
cord-295807-68sukdb1	834	88	treat	treat	VB
cord-295807-68sukdb1	834	89	diseases	disease	NNS
cord-295807-68sukdb1	834	90	involving	involve	VBG
cord-295807-68sukdb1	834	91	increased	increase	VBN
cord-295807-68sukdb1	834	92	bone	bone	NN
cord-295807-68sukdb1	834	93	mineral	mineral	NN
cord-295807-68sukdb1	834	94	density	density	NN
cord-295807-68sukdb1	834	95	?	?	.
cord-295807-68sukdb1	835	1	Chronic	chronic	JJ
cord-295807-68sukdb1	835	2	proton	proton	NN
cord-295807-68sukdb1	835	3	pump	pump	NN
cord-295807-68sukdb1	835	4	inihibitor	inihibitor	NN
cord-295807-68sukdb1	835	5	therapy	therapy	NN
cord-295807-68sukdb1	835	6	and	and	CC
cord-295807-68sukdb1	835	7	calcium	calcium	NN
cord-295807-68sukdb1	835	8	metabolism	metabolism	NN
cord-295807-68sukdb1	836	1	Proton	proton	NN
cord-295807-68sukdb1	836	2	-	-	HYPH
cord-295807-68sukdb1	836	3	pump	pump	NN
cord-295807-68sukdb1	836	4	Inhibitor	Inhibitor	NNP
cord-295807-68sukdb1	836	5	Use	Use	NNP
cord-295807-68sukdb1	836	6	and	and	CC
cord-295807-68sukdb1	836	7	Fracture	Fracture	NNP
cord-295807-68sukdb1	836	8	Risk	risk	NN
cord-295807-68sukdb1	836	9	:	:	:
cord-295807-68sukdb1	837	1	An	an	DT
cord-295807-68sukdb1	837	2	Updated	update	VBN
cord-295807-68sukdb1	837	3	Systematic	Systematic	NNP
cord-295807-68sukdb1	837	4	Review	Review	NNP
cord-295807-68sukdb1	837	5	and	and	CC
cord-295807-68sukdb1	837	6	Meta	Meta	NNP
cord-295807-68sukdb1	837	7	-	-	HYPH
cord-295807-68sukdb1	837	8	analysis	analysis	NN
cord-295807-68sukdb1	838	1	Proton	proton	NN
cord-295807-68sukdb1	838	2	pump	pump	NN
cord-295807-68sukdb1	838	3	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	838	4	therapy	therapy	NN
cord-295807-68sukdb1	838	5	and	and	CC
cord-295807-68sukdb1	838	6	risk	risk	NN
cord-295807-68sukdb1	838	7	of	of	IN
cord-295807-68sukdb1	838	8	bone	bone	NN
cord-295807-68sukdb1	838	9	diseases	disease	NNS
cord-295807-68sukdb1	838	10	:	:	:
cord-295807-68sukdb1	839	1	An	an	DT
cord-295807-68sukdb1	839	2	update	update	NN
cord-295807-68sukdb1	839	3	meta	meta	NN
cord-295807-68sukdb1	839	4	-	-	HYPH
cord-295807-68sukdb1	839	5	analysis	analysis	NN
cord-295807-68sukdb1	839	6	Revisiting	revisit	VBG
cord-295807-68sukdb1	839	7	the	the	DT
cord-295807-68sukdb1	839	8	parietal	parietal	JJ
cord-295807-68sukdb1	839	9	cell	cell	NN
cord-295807-68sukdb1	840	1	A	a	DT
cord-295807-68sukdb1	840	2	H+-gated	h+-gated	JJ
cord-295807-68sukdb1	840	3	urea	urea	NN
cord-295807-68sukdb1	840	4	channel	channel	NN
cord-295807-68sukdb1	841	1	:	:	:
cord-295807-68sukdb1	841	2	the	the	DT
cord-295807-68sukdb1	841	3	link	link	NN
cord-295807-68sukdb1	841	4	between	between	IN
cord-295807-68sukdb1	841	5	Helicobacter	Helicobacter	NNP
cord-295807-68sukdb1	841	6	pylori	pylori	NN
cord-295807-68sukdb1	841	7	urease	urease	NN
cord-295807-68sukdb1	841	8	and	and	CC
cord-295807-68sukdb1	841	9	gastric	gastric	JJ
cord-295807-68sukdb1	841	10	colonization	colonization	NN
cord-295807-68sukdb1	842	1	Helicobacter	Helicobacter	NNP
cord-295807-68sukdb1	842	2	pylori	pylori	NN
cord-295807-68sukdb1	842	3	moves	move	VBZ
cord-295807-68sukdb1	842	4	through	through	IN
cord-295807-68sukdb1	842	5	mucus	mucus	NN
cord-295807-68sukdb1	842	6	by	by	IN
cord-295807-68sukdb1	842	7	reducing	reduce	VBG
cord-295807-68sukdb1	842	8	mucin	mucin	NN
cord-295807-68sukdb1	842	9	viscoelasticity	viscoelasticity	NN
cord-295807-68sukdb1	842	10	Helicobacter	Helicobacter	NNP
cord-295807-68sukdb1	842	11	pylori	pylori	NN
cord-295807-68sukdb1	842	12	and	and	CC
cord-295807-68sukdb1	842	13	Gastric	gastric	JJ
cord-295807-68sukdb1	842	14	Cancer	cancer	NN
cord-295807-68sukdb1	842	15	:	:	:
cord-295807-68sukdb1	842	16	Factors	factor	NNS
cord-295807-68sukdb1	842	17	That	that	WDT
cord-295807-68sukdb1	842	18	Modulate	modulate	VBP
cord-295807-68sukdb1	842	19	Disease	Disease	NNP
cord-295807-68sukdb1	842	20	Risk	Risk	NNP
cord-295807-68sukdb1	842	21	Salivary	Salivary	NNP
cord-295807-68sukdb1	842	22	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	842	23	as	as	IN
cord-295807-68sukdb1	842	24	a	a	DT
cord-295807-68sukdb1	842	25	major	major	JJ
cord-295807-68sukdb1	842	26	factor	factor	NN
cord-295807-68sukdb1	842	27	in	in	IN
cord-295807-68sukdb1	842	28	the	the	DT
cord-295807-68sukdb1	842	29	prevention	prevention	NN
cord-295807-68sukdb1	842	30	of	of	IN
cord-295807-68sukdb1	842	31	upper	upper	JJ
cord-295807-68sukdb1	842	32	esophageal	esophageal	JJ
cord-295807-68sukdb1	842	33	mucosal	mucosal	JJ
cord-295807-68sukdb1	842	34	injury	injury	NN
cord-295807-68sukdb1	842	35	in	in	IN
cord-295807-68sukdb1	842	36	gastroesophageal	gastroesophageal	JJ
cord-295807-68sukdb1	842	37	reflux	reflux	NN
cord-295807-68sukdb1	842	38	disease	disease	NN
cord-295807-68sukdb1	842	39	Analysis	Analysis	NNP
cord-295807-68sukdb1	842	40	of	of	IN
cord-295807-68sukdb1	842	41	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	842	42	,	,	,
cord-295807-68sukdb1	842	43	phosphate	phosphate	NN
cord-295807-68sukdb1	842	44	and	and	CC
cord-295807-68sukdb1	842	45	other	other	JJ
cord-295807-68sukdb1	842	46	anions	anion	NNS
cord-295807-68sukdb1	842	47	in	in	IN
cord-295807-68sukdb1	842	48	saliva	saliva	NN
cord-295807-68sukdb1	842	49	by	by	IN
cord-295807-68sukdb1	842	50	capillary	capillary	JJ
cord-295807-68sukdb1	842	51	electrophoresis	electrophoresis	NN
cord-295807-68sukdb1	842	52	with	with	IN
cord-295807-68sukdb1	842	53	capacitively	capacitively	RB
cord-295807-68sukdb1	842	54	coupled	couple	VBN
cord-295807-68sukdb1	842	55	contactless	contactless	JJ
cord-295807-68sukdb1	842	56	conductivity	conductivity	NN
cord-295807-68sukdb1	842	57	detection	detection	NN
cord-295807-68sukdb1	842	58	in	in	IN
cord-295807-68sukdb1	842	59	diagnostics	diagnostic	NNS
cord-295807-68sukdb1	842	60	of	of	IN
cord-295807-68sukdb1	842	61	gastroesophageal	gastroesophageal	JJ
cord-295807-68sukdb1	842	62	reflux	reflux	NN
cord-295807-68sukdb1	842	63	disease	disease	NN
cord-295807-68sukdb1	842	64	Role	role	NN
cord-295807-68sukdb1	842	65	of	of	IN
cord-295807-68sukdb1	842	66	Saliva	saliva	NN
cord-295807-68sukdb1	842	67	in	in	IN
cord-295807-68sukdb1	842	68	Esophageal	Esophageal	NNP
cord-295807-68sukdb1	842	69	Defense	defense	NN
cord-295807-68sukdb1	842	70	:	:	:
cord-295807-68sukdb1	842	71	Implications	implication	NNS
cord-295807-68sukdb1	842	72	in	in	IN
cord-295807-68sukdb1	842	73	Patients	patient	NNS
cord-295807-68sukdb1	842	74	With	with	IN
cord-295807-68sukdb1	842	75	Nonerosive	Nonerosive	NNP
cord-295807-68sukdb1	842	76	Reflux	reflux	NN
cord-295807-68sukdb1	842	77	Disease	Disease	NNP
cord-295807-68sukdb1	842	78	Acid	acid	NN
cord-295807-68sukdb1	842	79	neutralizing	neutralize	VBG
cord-295807-68sukdb1	842	80	capacity	capacity	NN
cord-295807-68sukdb1	842	81	of	of	IN
cord-295807-68sukdb1	842	82	human	human	JJ
cord-295807-68sukdb1	842	83	saliva	saliva	NN
cord-295807-68sukdb1	842	84	Physiology	Physiology	NNP
cord-295807-68sukdb1	842	85	of	of	IN
cord-295807-68sukdb1	842	86	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	842	87	Exchangers	Exchangers	NNPS
cord-295807-68sukdb1	842	88	(	(	-LRB-
cord-295807-68sukdb1	842	89	NHEs	NHEs	NNP
cord-295807-68sukdb1	842	90	)	)	-RRB-
cord-295807-68sukdb1	842	91	in	in	IN
cord-295807-68sukdb1	842	92	the	the	DT
cord-295807-68sukdb1	842	93	Digestive	Digestive	NNP
cord-295807-68sukdb1	842	94	System	System	NNP
cord-295807-68sukdb1	842	95	Milk	Milk	NNP
cord-295807-68sukdb1	842	96	-	-	HYPH
cord-295807-68sukdb1	842	97	Alkali	Alkali	NNP
cord-295807-68sukdb1	842	98	Syndrome	Syndrome	NNP
cord-295807-68sukdb1	842	99	Health	Health	NNP
cord-295807-68sukdb1	842	100	-	-	HYPH
cord-295807-68sukdb1	842	101	Behavior	Behavior	NNP
cord-295807-68sukdb1	842	102	Induced	Induced	NNP
cord-295807-68sukdb1	842	103	Disease	Disease	NNP
cord-295807-68sukdb1	842	104	:	:	:
cord-295807-68sukdb1	842	105	Return	return	NN
cord-295807-68sukdb1	842	106	of	of	IN
cord-295807-68sukdb1	842	107	the	the	DT
cord-295807-68sukdb1	842	108	Milk	Milk	NNP
cord-295807-68sukdb1	842	109	-	-	HYPH
cord-295807-68sukdb1	842	110	Alkali	Alkali	NNP
cord-295807-68sukdb1	842	111	Syndrome	Syndrome	NNP
cord-295807-68sukdb1	842	112	Regulation	regulation	NN
cord-295807-68sukdb1	842	113	of	of	IN
cord-295807-68sukdb1	842	114	Na	Na	NNP
cord-295807-68sukdb1	842	115	/	/	SYM
cord-295807-68sukdb1	842	116	H	h	NN
cord-295807-68sukdb1	842	117	exchanger-1	exchanger-1	NNP
cord-295807-68sukdb1	842	118	in	in	IN
cord-295807-68sukdb1	842	119	gastroesophageal	gastroesophageal	JJ
cord-295807-68sukdb1	842	120	reflux	reflux	NN
cord-295807-68sukdb1	842	121	disease	disease	NN
cord-295807-68sukdb1	842	122	:	:	:
cord-295807-68sukdb1	842	123	possible	possible	JJ
cord-295807-68sukdb1	842	124	interaction	interaction	NN
cord-295807-68sukdb1	842	125	of	of	IN
cord-295807-68sukdb1	842	126	histamine	histamine	NN
cord-295807-68sukdb1	842	127	receptor	receptor	NN
cord-295807-68sukdb1	842	128	Mice	mouse	NNS
cord-295807-68sukdb1	842	129	with	with	IN
cord-295807-68sukdb1	842	130	a	a	DT
cord-295807-68sukdb1	842	131	targeted	target	VBN
cord-295807-68sukdb1	842	132	disruption	disruption	NN
cord-295807-68sukdb1	842	133	of	of	IN
cord-295807-68sukdb1	842	134	the	the	DT
cord-295807-68sukdb1	842	135	AE2	AE2	NNP
cord-295807-68sukdb1	842	136	Cl	Cl	NNP
cord-295807-68sukdb1	842	137	-/HCO3	-/hco3	POS
cord-295807-68sukdb1	842	138	-exchanger	-exchanger	.
cord-295807-68sukdb1	843	1	are	be	VBP
cord-295807-68sukdb1	843	2	achlorhydric	achlorhydric	EX
cord-295807-68sukdb1	843	3	The	the	DT
cord-295807-68sukdb1	843	4	role	role	NN
cord-295807-68sukdb1	843	5	of	of	IN
cord-295807-68sukdb1	843	6	acid	acid	JJ
cord-295807-68sukdb1	843	7	inhibition	inhibition	NN
cord-295807-68sukdb1	843	8	in	in	IN
cord-295807-68sukdb1	843	9	Helicobacter	Helicobacter	NNP
cord-295807-68sukdb1	843	10	pylori	pylori	NN
cord-295807-68sukdb1	843	11	eradication	eradication	NN
cord-295807-68sukdb1	844	1	The	the	DT
cord-295807-68sukdb1	844	2	Development	Development	NNP
cord-295807-68sukdb1	844	3	of	of	IN
cord-295807-68sukdb1	844	4	Urease	Urease	NNP
cord-295807-68sukdb1	844	5	Inhibitors	Inhibitors	NNP
cord-295807-68sukdb1	844	6	:	:	:
cord-295807-68sukdb1	845	1	What	what	WDT
cord-295807-68sukdb1	845	2	Opportunities	opportunity	NNS
cord-295807-68sukdb1	845	3	Exist	exist	VBP
cord-295807-68sukdb1	845	4	for	for	IN
cord-295807-68sukdb1	845	5	Better	Better	NNP
cord-295807-68sukdb1	845	6	Treatment	Treatment	NNP
cord-295807-68sukdb1	845	7	of	of	IN
cord-295807-68sukdb1	845	8	Helicobacter	Helicobacter	NNP
cord-295807-68sukdb1	845	9	pylori	pylori	NN
cord-295807-68sukdb1	845	10	Infection	infection	NN
cord-295807-68sukdb1	845	11	in	in	IN
cord-295807-68sukdb1	845	12	Children	child	NNS
cord-295807-68sukdb1	845	13	?	?	.
cord-295807-68sukdb1	846	1	The	the	DT
cord-295807-68sukdb1	846	2	Cystic	Cystic	NNP
cord-295807-68sukdb1	846	3	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	846	4	of	of	IN
cord-295807-68sukdb1	846	5	Exocrine	Exocrine	NNP
cord-295807-68sukdb1	846	6	Pancreas	Pancreas	NNP
cord-295807-68sukdb1	846	7	Intestinal	intestinal	JJ
cord-295807-68sukdb1	846	8	Obstruction	obstruction	NN
cord-295807-68sukdb1	846	9	Syndromes	Syndromes	NNPS
cord-295807-68sukdb1	846	10	in	in	IN
cord-295807-68sukdb1	846	11	Cystic	Cystic	NNP
cord-295807-68sukdb1	846	12	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	846	13	:	:	:
cord-295807-68sukdb1	847	1	Meconium	Meconium	NNP
cord-295807-68sukdb1	847	2	Ileus	Ileus	NNP
cord-295807-68sukdb1	847	3	,	,	,
cord-295807-68sukdb1	847	4	Distal	Distal	NNP
cord-295807-68sukdb1	847	5	Intestinal	intestinal	JJ
cord-295807-68sukdb1	847	6	Obstruction	Obstruction	NNP
cord-295807-68sukdb1	847	7	Syndrome	Syndrome	NNP
cord-295807-68sukdb1	847	8	,	,	,
cord-295807-68sukdb1	847	9	and	and	CC
cord-295807-68sukdb1	847	10	Constipation	constipation	NN
cord-295807-68sukdb1	847	11	Acid	acid	NN
cord-295807-68sukdb1	847	12	-	-	HYPH
cord-295807-68sukdb1	847	13	Base	Base	NNP
cord-295807-68sukdb1	847	14	Disturbances	Disturbances	NNPS
cord-295807-68sukdb1	847	15	in	in	IN
cord-295807-68sukdb1	847	16	Gastrointestinal	Gastrointestinal	NNP
cord-295807-68sukdb1	847	17	Disease	Disease	NNP
cord-295807-68sukdb1	847	18	Update	update	NN
cord-295807-68sukdb1	847	19	on	on	IN
cord-295807-68sukdb1	847	20	SLC26A3	slc26a3	NN
cord-295807-68sukdb1	847	21	mutations	mutation	NNS
cord-295807-68sukdb1	847	22	in	in	IN
cord-295807-68sukdb1	847	23	congenital	congenital	JJ
cord-295807-68sukdb1	847	24	chloride	chloride	NN
cord-295807-68sukdb1	847	25	diarrhea	diarrhea	NN
cord-295807-68sukdb1	847	26	Differential	differential	JJ
cord-295807-68sukdb1	847	27	regulation	regulation	NN
cord-295807-68sukdb1	847	28	of	of	IN
cord-295807-68sukdb1	847	29	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	847	30	exchange	exchange	NN
cord-295807-68sukdb1	847	31	isoform	isoform	NN
cord-295807-68sukdb1	847	32	activities	activity	NNS
cord-295807-68sukdb1	847	33	by	by	IN
cord-295807-68sukdb1	847	34	enteropathogenic	enteropathogenic	JJ
cord-295807-68sukdb1	847	35	E.	E.	NNP
cord-295807-68sukdb1	847	36	coli	coli	NNS
cord-295807-68sukdb1	847	37	in	in	IN
cord-295807-68sukdb1	847	38	human	human	JJ
cord-295807-68sukdb1	847	39	intestinal	intestinal	JJ
cord-295807-68sukdb1	847	40	epithelial	epithelial	JJ
cord-295807-68sukdb1	847	41	cells	cell	NNS
cord-295807-68sukdb1	847	42	Inhibition	inhibition	NN
cord-295807-68sukdb1	847	43	and	and	CC
cord-295807-68sukdb1	847	44	redistribution	redistribution	NN
cord-295807-68sukdb1	847	45	of	of	IN
cord-295807-68sukdb1	847	46	NHE3	NHE3	NNP
cord-295807-68sukdb1	847	47	,	,	,
cord-295807-68sukdb1	847	48	the	the	DT
cord-295807-68sukdb1	847	49	apical	apical	JJ
cord-295807-68sukdb1	847	50	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	847	51	exchanger	exchanger	NN
cord-295807-68sukdb1	847	52	,	,	,
cord-295807-68sukdb1	847	53	by	by	IN
cord-295807-68sukdb1	847	54	Clostridium	clostridium	NN
cord-295807-68sukdb1	847	55	difficile	difficile	NN
cord-295807-68sukdb1	847	56	toxin	toxin	NN
cord-295807-68sukdb1	847	57	B	b	NN
cord-295807-68sukdb1	847	58	Reduced	reduce	VBN
cord-295807-68sukdb1	847	59	sodium	sodium	NN
cord-295807-68sukdb1	847	60	/	/	SYM
cord-295807-68sukdb1	847	61	proton	proton	NN
cord-295807-68sukdb1	847	62	exchanger	exchanger	NN
cord-295807-68sukdb1	847	63	NHE3	NHE3	NNP
cord-295807-68sukdb1	848	1	activity	activity	NN
cord-295807-68sukdb1	848	2	causes	cause	VBZ
cord-295807-68sukdb1	848	3	congenital	congenital	JJ
cord-295807-68sukdb1	848	4	sodium	sodium	NN
cord-295807-68sukdb1	848	5	diarrhea	diarrhea	NN
cord-295807-68sukdb1	849	1	pH	pH	NNP
cord-295807-68sukdb1	849	2	and	and	CC
cord-295807-68sukdb1	849	3	peptide	peptide	JJ
cord-295807-68sukdb1	849	4	supply	supply	NN
cord-295807-68sukdb1	849	5	can	can	MD
cord-295807-68sukdb1	849	6	radically	radically	RB
cord-295807-68sukdb1	849	7	alter	alter	VB
cord-295807-68sukdb1	849	8	bacterial	bacterial	JJ
cord-295807-68sukdb1	849	9	populations	population	NNS
cord-295807-68sukdb1	849	10	and	and	CC
cord-295807-68sukdb1	849	11	short	short	JJ
cord-295807-68sukdb1	849	12	-	-	HYPH
cord-295807-68sukdb1	849	13	chain	chain	NN
cord-295807-68sukdb1	849	14	fatty	fatty	JJ
cord-295807-68sukdb1	849	15	acid	acid	NN
cord-295807-68sukdb1	849	16	ratios	ratio	NNS
cord-295807-68sukdb1	849	17	within	within	IN
cord-295807-68sukdb1	849	18	microbial	microbial	JJ
cord-295807-68sukdb1	849	19	communities	community	NNS
cord-295807-68sukdb1	849	20	from	from	IN
cord-295807-68sukdb1	849	21	the	the	DT
cord-295807-68sukdb1	849	22	human	human	JJ
cord-295807-68sukdb1	849	23	colon	colon	NN
cord-295807-68sukdb1	849	24	D	d	NN
cord-295807-68sukdb1	849	25	-	-	HYPH
cord-295807-68sukdb1	849	26	lactic	lactic	JJ
cord-295807-68sukdb1	849	27	acidosis	acidosis	NN
cord-295807-68sukdb1	849	28	:	:	:
cord-295807-68sukdb1	849	29	an	an	DT
cord-295807-68sukdb1	849	30	underrecognized	underrecognized	JJ
cord-295807-68sukdb1	849	31	complication	complication	NN
cord-295807-68sukdb1	849	32	of	of	IN
cord-295807-68sukdb1	849	33	short	short	JJ
cord-295807-68sukdb1	849	34	bowel	bowel	NN
cord-295807-68sukdb1	849	35	syndrome	syndrome	NN
cord-295807-68sukdb1	850	1	H+-coupled	h+-coupled	JJ
cord-295807-68sukdb1	850	2	nutrient	nutrient	NN
cord-295807-68sukdb1	850	3	,	,	,
cord-295807-68sukdb1	850	4	micronutrient	micronutrient	NN
cord-295807-68sukdb1	850	5	and	and	CC
cord-295807-68sukdb1	850	6	drug	drug	NN
cord-295807-68sukdb1	850	7	transporters	transporter	NNS
cord-295807-68sukdb1	850	8	in	in	IN
cord-295807-68sukdb1	850	9	the	the	DT
cord-295807-68sukdb1	850	10	mammalian	mammalian	JJ
cord-295807-68sukdb1	850	11	small	small	JJ
cord-295807-68sukdb1	850	12	intestine	intestine	NN
cord-295807-68sukdb1	850	13	Defective	defective	JJ
cord-295807-68sukdb1	850	14	small	small	JJ
cord-295807-68sukdb1	850	15	intestinal	intestinal	JJ
cord-295807-68sukdb1	850	16	anion	anion	NN
cord-295807-68sukdb1	850	17	secretion	secretion	NN
cord-295807-68sukdb1	850	18	,	,	,
cord-295807-68sukdb1	850	19	dipeptide	dipeptide	JJ
cord-295807-68sukdb1	850	20	absorption	absorption	NN
cord-295807-68sukdb1	850	21	,	,	,
cord-295807-68sukdb1	850	22	and	and	CC
cord-295807-68sukdb1	850	23	intestinal	intestinal	JJ
cord-295807-68sukdb1	850	24	failure	failure	NN
cord-295807-68sukdb1	850	25	in	in	IN
cord-295807-68sukdb1	850	26	suckling	suckle	VBG
cord-295807-68sukdb1	850	27	NBCe1-deficient	nbce1-deficient	CD
cord-295807-68sukdb1	850	28	mice	mouse	NNS
cord-295807-68sukdb1	850	29	SLC26A3	slc26a3	NN
cord-295807-68sukdb1	850	30	inhibitor	inhibitor	NN
cord-295807-68sukdb1	850	31	identified	identify	VBN
cord-295807-68sukdb1	850	32	in	in	IN
cord-295807-68sukdb1	850	33	small	small	JJ
cord-295807-68sukdb1	850	34	molecule	molecule	NN
cord-295807-68sukdb1	850	35	screen	screen	NN
cord-295807-68sukdb1	850	36	blocks	block	VBZ
cord-295807-68sukdb1	850	37	colonic	colonic	JJ
cord-295807-68sukdb1	850	38	fluid	fluid	JJ
cord-295807-68sukdb1	850	39	absorption	absorption	NN
cord-295807-68sukdb1	850	40	and	and	CC
cord-295807-68sukdb1	850	41	reduces	reduce	VBZ
cord-295807-68sukdb1	850	42	constipation	constipation	NN
cord-295807-68sukdb1	850	43	Efficacy	Efficacy	NNP
cord-295807-68sukdb1	850	44	of	of	IN
cord-295807-68sukdb1	850	45	Tenapanor	Tenapanor	NNP
cord-295807-68sukdb1	850	46	in	in	IN
cord-295807-68sukdb1	850	47	Treating	treat	VBG
cord-295807-68sukdb1	850	48	Patients	patient	NNS
cord-295807-68sukdb1	850	49	With	with	IN
cord-295807-68sukdb1	850	50	Irritable	irritable	JJ
cord-295807-68sukdb1	850	51	Bowel	Bowel	NNP
cord-295807-68sukdb1	850	52	Syndrome	syndrome	NN
cord-295807-68sukdb1	850	53	With	with	IN
cord-295807-68sukdb1	850	54	Constipation	constipation	NN
cord-295807-68sukdb1	850	55	:	:	:
cord-295807-68sukdb1	850	56	A	a	DT
cord-295807-68sukdb1	850	57	12-Week	12-week	CD
cord-295807-68sukdb1	850	58	,	,	,
cord-295807-68sukdb1	850	59	Placebo	Placebo	NNP
cord-295807-68sukdb1	850	60	-	-	HYPH
cord-295807-68sukdb1	850	61	Controlled	Controlled	NNP
cord-295807-68sukdb1	850	62	Phase	Phase	NNP
cord-295807-68sukdb1	850	63	3	3	CD
cord-295807-68sukdb1	850	64	Trial	Trial	NNP
cord-295807-68sukdb1	850	65	(	(	-LRB-
cord-295807-68sukdb1	850	66	T3MPO-1	t3mpo-1	CD
cord-295807-68sukdb1	850	67	)	)	-RRB-
cord-295807-68sukdb1	850	68	Impact	impact	NN
cord-295807-68sukdb1	850	69	of	of	IN
cord-295807-68sukdb1	850	70	CFTR	CFTR	NNP
cord-295807-68sukdb1	850	71	Modulation	Modulation	NNP
cord-295807-68sukdb1	850	72	on	on	IN
cord-295807-68sukdb1	850	73	Intestinal	intestinal	JJ
cord-295807-68sukdb1	850	74	pH	ph	NN
cord-295807-68sukdb1	850	75	,	,	,
cord-295807-68sukdb1	850	76	Motility	Motility	NNP
cord-295807-68sukdb1	850	77	,	,	,
cord-295807-68sukdb1	850	78	and	and	CC
cord-295807-68sukdb1	850	79	Clinical	Clinical	NNP
cord-295807-68sukdb1	850	80	Outcomes	Outcomes	NNPS
cord-295807-68sukdb1	850	81	in	in	IN
cord-295807-68sukdb1	850	82	Patients	patient	NNS
cord-295807-68sukdb1	850	83	With	with	IN
cord-295807-68sukdb1	850	84	Cystic	Cystic	NNP
cord-295807-68sukdb1	850	85	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	850	86	and	and	CC
cord-295807-68sukdb1	850	87	the	the	DT
cord-295807-68sukdb1	850	88	G551D	G551D	NNP
cord-295807-68sukdb1	850	89	Mutation	Mutation	NNP
cord-295807-68sukdb1	850	90	Linaclotide	Linaclotide	NNP
cord-295807-68sukdb1	850	91	improves	improve	VBZ
cord-295807-68sukdb1	850	92	gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	850	93	transit	transit	NN
cord-295807-68sukdb1	850	94	in	in	IN
cord-295807-68sukdb1	850	95	cystic	cystic	JJ
cord-295807-68sukdb1	850	96	fibrosis	fibrosis	NN
cord-295807-68sukdb1	850	97	mice	mouse	NNS
cord-295807-68sukdb1	850	98	by	by	IN
cord-295807-68sukdb1	850	99	inhibiting	inhibit	VBG
cord-295807-68sukdb1	850	100	sodium	sodium	NN
cord-295807-68sukdb1	850	101	/	/	SYM
cord-295807-68sukdb1	850	102	hydrogen	hydrogen	NN
cord-295807-68sukdb1	850	103	exchanger	exchanger	NN
cord-295807-68sukdb1	851	1	3	3	LS
cord-295807-68sukdb1	851	2	Linaclotide	Linaclotide	NNP
cord-295807-68sukdb1	851	3	activates	activate	VBZ
cord-295807-68sukdb1	851	4	guanylate	guanylate	NN
cord-295807-68sukdb1	851	5	cyclase	cyclase	NN
cord-295807-68sukdb1	851	6	-	-	HYPH
cord-295807-68sukdb1	851	7	C	C	NNP
cord-295807-68sukdb1	851	8	/	/	SYM
cord-295807-68sukdb1	851	9	cGMP	cGMP	NNP
cord-295807-68sukdb1	851	10	/	/	SYM
cord-295807-68sukdb1	851	11	protein	protein	NN
cord-295807-68sukdb1	851	12	kinase	kinase	NN
cord-295807-68sukdb1	851	13	-	-	HYPH
cord-295807-68sukdb1	851	14	II	ii	NN
cord-295807-68sukdb1	851	15	-	-	HYPH
cord-295807-68sukdb1	851	16	dependent	dependent	JJ
cord-295807-68sukdb1	851	17	trafficking	trafficking	NN
cord-295807-68sukdb1	851	18	of	of	IN
cord-295807-68sukdb1	851	19	CFTR	CFTR	NNP
cord-295807-68sukdb1	851	20	in	in	IN
cord-295807-68sukdb1	851	21	the	the	DT
cord-295807-68sukdb1	851	22	intestine	intestine	NN
cord-295807-68sukdb1	851	23	Medical	Medical	NNP
cord-295807-68sukdb1	851	24	Physiology	Physiology	NNP
cord-295807-68sukdb1	851	25	.	.	.
cord-295807-68sukdb1	852	1	A	a	DT
cord-295807-68sukdb1	852	2	Cellular	Cellular	NNP
cord-295807-68sukdb1	852	3	and	and	CC
cord-295807-68sukdb1	852	4	Molecular	Molecular	NNP
cord-295807-68sukdb1	852	5	Approach	Approach	NNP
cord-295807-68sukdb1	853	1	Renal	Renal	NNP
cord-295807-68sukdb1	853	2	Tubular	Tubular	NNP
cord-295807-68sukdb1	853	3	Acidosis	Acidosis	NNP
cord-295807-68sukdb1	853	4	Metabolic	metabolic	JJ
cord-295807-68sukdb1	853	5	Acidosis	acidosis	NN
cord-295807-68sukdb1	853	6	and	and	CC
cord-295807-68sukdb1	853	7	Subclinical	Subclinical	NNP
cord-295807-68sukdb1	853	8	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	853	9	Acidosis	acidosis	NN
cord-295807-68sukdb1	853	10	in	in	IN
cord-295807-68sukdb1	853	11	CKD	CKD	NNP
cord-295807-68sukdb1	853	12	Downregulation	Downregulation	NNP
cord-295807-68sukdb1	853	13	of	of	IN
cord-295807-68sukdb1	853	14	the	the	DT
cord-295807-68sukdb1	853	15	Cl-/HCO3-Exchanger	cl-/hco3-exchanger	CD
cord-295807-68sukdb1	853	16	Pendrin	Pendrin	NNP
cord-295807-68sukdb1	853	17	in	in	IN
cord-295807-68sukdb1	853	18	Kidneys	kidney	NNS
cord-295807-68sukdb1	853	19	of	of	IN
cord-295807-68sukdb1	853	20	Mice	mouse	NNS
cord-295807-68sukdb1	853	21	with	with	IN
cord-295807-68sukdb1	853	22	Cystic	Cystic	NNP
cord-295807-68sukdb1	853	23	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	853	24	:	:	:
cord-295807-68sukdb1	854	1	Role	role	NN
cord-295807-68sukdb1	854	2	in	in	IN
cord-295807-68sukdb1	854	3	the	the	DT
cord-295807-68sukdb1	854	4	Pathogenesis	Pathogenesis	NNP
cord-295807-68sukdb1	854	5	of	of	IN
cord-295807-68sukdb1	854	6	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	854	7	Alkalosis	Alkalosis	NNP
cord-295807-68sukdb1	854	8	Mechanisms	Mechanisms	NNPS
cord-295807-68sukdb1	854	9	of	of	IN
cord-295807-68sukdb1	854	10	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	854	11	Acidosis	acidosis	NN
cord-295807-68sukdb1	854	12	-	-	HYPH
cord-295807-68sukdb1	854	13	Induced	induce	VBN
cord-295807-68sukdb1	854	14	Kidney	kidney	NN
cord-295807-68sukdb1	854	15	Injury	injury	NN
cord-295807-68sukdb1	854	16	in	in	IN
cord-295807-68sukdb1	854	17	Chronic	Chronic	NNP
cord-295807-68sukdb1	854	18	Kidney	Kidney	NNP
cord-295807-68sukdb1	854	19	Disease	Disease	NNP
cord-295807-68sukdb1	854	20	Low	Low	NNP
cord-295807-68sukdb1	854	21	Serum	Serum	NNP
cord-295807-68sukdb1	854	22	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	854	23	and	and	CC
cord-295807-68sukdb1	854	24	CKD	CKD	NNP
cord-295807-68sukdb1	854	25	Progression	Progression	NNP
cord-295807-68sukdb1	854	26	in	in	IN
cord-295807-68sukdb1	854	27	Children	Children	NNP
cord-295807-68sukdb1	854	28	Serum	serum	NN
cord-295807-68sukdb1	854	29	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	854	30	levels	level	NNS
cord-295807-68sukdb1	854	31	and	and	CC
cord-295807-68sukdb1	854	32	the	the	DT
cord-295807-68sukdb1	854	33	progression	progression	NN
cord-295807-68sukdb1	854	34	of	of	IN
cord-295807-68sukdb1	854	35	kidney	kidney	NN
cord-295807-68sukdb1	854	36	disease	disease	NN
cord-295807-68sukdb1	854	37	:	:	:
cord-295807-68sukdb1	854	38	a	a	DT
cord-295807-68sukdb1	854	39	cohort	cohort	NN
cord-295807-68sukdb1	854	40	study	study	NN
cord-295807-68sukdb1	854	41	Mechanism	Mechanism	NNP
cord-295807-68sukdb1	854	42	of	of	IN
cord-295807-68sukdb1	854	43	Hyperkalemia	Hyperkalemia	NNP
cord-295807-68sukdb1	854	44	-	-	HYPH
cord-295807-68sukdb1	854	45	Induced	induce	VBN
cord-295807-68sukdb1	854	46	Metabolic	metabolic	JJ
cord-295807-68sukdb1	854	47	Acidosis	acidosis	NN
cord-295807-68sukdb1	854	48	Kidney	kidney	NN
cord-295807-68sukdb1	854	49	stones	stone	NNS
cord-295807-68sukdb1	854	50	:	:	:
cord-295807-68sukdb1	854	51	pathophysiology	pathophysiology	NN
cord-295807-68sukdb1	854	52	and	and	CC
cord-295807-68sukdb1	854	53	medical	medical	JJ
cord-295807-68sukdb1	854	54	management	management	NN
cord-295807-68sukdb1	855	1	The	the	DT
cord-295807-68sukdb1	855	2	primary	primary	JJ
cord-295807-68sukdb1	855	3	cause	cause	NN
cord-295807-68sukdb1	855	4	of	of	IN
cord-295807-68sukdb1	855	5	infection	infection	NN
cord-295807-68sukdb1	855	6	-	-	HYPH
cord-295807-68sukdb1	855	7	induced	induce	VBN
cord-295807-68sukdb1	855	8	urinary	urinary	JJ
cord-295807-68sukdb1	855	9	stones	stone	NNS
cord-295807-68sukdb1	856	1	Urinary	urinary	JJ
cord-295807-68sukdb1	856	2	catheter	catheter	NN
cord-295807-68sukdb1	856	3	blockage	blockage	NN
cord-295807-68sukdb1	856	4	depends	depend	VBZ
cord-295807-68sukdb1	856	5	on	on	IN
cord-295807-68sukdb1	856	6	urine	urine	NN
cord-295807-68sukdb1	856	7	pH	ph	NN
cord-295807-68sukdb1	856	8	,	,	,
cord-295807-68sukdb1	856	9	calcium	calcium	NN
cord-295807-68sukdb1	856	10	and	and	CC
cord-295807-68sukdb1	856	11	rate	rate	NN
cord-295807-68sukdb1	856	12	of	of	IN
cord-295807-68sukdb1	856	13	flow	flow	NN
cord-295807-68sukdb1	857	1	Daily	daily	JJ
cord-295807-68sukdb1	857	2	oral	oral	JJ
cord-295807-68sukdb1	857	3	sodium	sodium	NN
cord-295807-68sukdb1	857	4	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	857	5	preserves	preserve	VBZ
cord-295807-68sukdb1	857	6	glomerular	glomerular	JJ
cord-295807-68sukdb1	857	7	filtration	filtration	NN
cord-295807-68sukdb1	857	8	rate	rate	NN
cord-295807-68sukdb1	857	9	by	by	IN
cord-295807-68sukdb1	857	10	slowing	slow	VBG
cord-295807-68sukdb1	857	11	its	-PRON-	PRP$
cord-295807-68sukdb1	857	12	decline	decline	NN
cord-295807-68sukdb1	857	13	in	in	IN
cord-295807-68sukdb1	857	14	early	early	JJ
cord-295807-68sukdb1	857	15	hypertensive	hypertensive	JJ
cord-295807-68sukdb1	857	16	nephropathy	nephropathy	NN
cord-295807-68sukdb1	857	17	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	857	18	supplementation	supplementation	NN
cord-295807-68sukdb1	857	19	slows	slow	VBZ
cord-295807-68sukdb1	857	20	progression	progression	NN
cord-295807-68sukdb1	857	21	of	of	IN
cord-295807-68sukdb1	857	22	CKD	CKD	NNP
cord-295807-68sukdb1	857	23	and	and	CC
cord-295807-68sukdb1	857	24	improves	improve	VBZ
cord-295807-68sukdb1	857	25	nutritional	nutritional	JJ
cord-295807-68sukdb1	857	26	status	status	NN
cord-295807-68sukdb1	857	27	Clinical	clinical	JJ
cord-295807-68sukdb1	857	28	evidence	evidence	NN
cord-295807-68sukdb1	857	29	that	that	IN
cord-295807-68sukdb1	857	30	treatment	treatment	NN
cord-295807-68sukdb1	857	31	of	of	IN
cord-295807-68sukdb1	857	32	metabolic	metabolic	JJ
cord-295807-68sukdb1	857	33	acidosis	acidosis	NN
cord-295807-68sukdb1	857	34	slows	slow	VBZ
cord-295807-68sukdb1	857	35	the	the	DT
cord-295807-68sukdb1	857	36	progression	progression	NN
cord-295807-68sukdb1	857	37	of	of	IN
cord-295807-68sukdb1	857	38	chronic	chronic	JJ
cord-295807-68sukdb1	857	39	kidney	kidney	NN
cord-295807-68sukdb1	857	40	disease	disease	NN
cord-295807-68sukdb1	857	41	A	a	DT
cord-295807-68sukdb1	857	42	Causative	causative	JJ
cord-295807-68sukdb1	857	43	Role	role	NN
cord-295807-68sukdb1	857	44	for	for	IN
cord-295807-68sukdb1	857	45	Redox	Redox	NNP
cord-295807-68sukdb1	857	46	Cycling	Cycling	NNP
cord-295807-68sukdb1	857	47	of	of	IN
cord-295807-68sukdb1	857	48	Myoglobin	Myoglobin	NNP
cord-295807-68sukdb1	857	49	and	and	CC
cord-295807-68sukdb1	857	50	Its	-PRON-	PRP$
cord-295807-68sukdb1	857	51	Inhibition	inhibition	NN
cord-295807-68sukdb1	857	52	by	by	IN
cord-295807-68sukdb1	857	53	Alkalinization	Alkalinization	NNP
cord-295807-68sukdb1	857	54	in	in	IN
cord-295807-68sukdb1	857	55	the	the	DT
cord-295807-68sukdb1	857	56	Pathogenesis	Pathogenesis	NNP
cord-295807-68sukdb1	857	57	and	and	CC
cord-295807-68sukdb1	857	58	Treatment	Treatment	NNP
cord-295807-68sukdb1	857	59	of	of	IN
cord-295807-68sukdb1	857	60	Rhabdomyolysis	rhabdomyolysis	NN
cord-295807-68sukdb1	857	61	-	-	HYPH
cord-295807-68sukdb1	857	62	induced	induce	VBN
cord-295807-68sukdb1	857	63	Renal	Renal	NNP
cord-295807-68sukdb1	857	64	Failure	Failure	NNP
cord-295807-68sukdb1	857	65	Drug	Drug	NNP
cord-295807-68sukdb1	857	66	-	-	HYPH
cord-295807-68sukdb1	857	67	induced	induce	VBN
cord-295807-68sukdb1	857	68	renal	renal	JJ
cord-295807-68sukdb1	857	69	Fanconi	Fanconi	NNP
cord-295807-68sukdb1	857	70	syndrome	syndrome	NN
cord-295807-68sukdb1	857	71	Diuretics	diuretic	NNS
cord-295807-68sukdb1	857	72	:	:	:
cord-295807-68sukdb1	857	73	a	a	DT
cord-295807-68sukdb1	857	74	review	review	NN
cord-295807-68sukdb1	858	1	Metabolic	metabolic	JJ
cord-295807-68sukdb1	858	2	Alkalosis	Alkalosis	NNP
cord-295807-68sukdb1	859	1	The	the	DT
cord-295807-68sukdb1	859	2	behavior	behavior	NN
cord-295807-68sukdb1	859	3	of	of	IN
cord-295807-68sukdb1	859	4	carbenicillin	carbenicillin	NNP
cord-295807-68sukdb1	859	5	as	as	IN
cord-295807-68sukdb1	859	6	a	a	DT
cord-295807-68sukdb1	859	7	nonreabsorbable	nonreabsorbable	JJ
cord-295807-68sukdb1	859	8	anion	anion	NN
cord-295807-68sukdb1	859	9	Hypokalaemia	Hypokalaemia	NNP
cord-295807-68sukdb1	859	10	,	,	,
cord-295807-68sukdb1	859	11	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	859	12	Alkalosis	Alkalosis	NNP
cord-295807-68sukdb1	859	13	,	,	,
cord-295807-68sukdb1	859	14	and	and	CC
cord-295807-68sukdb1	859	15	Hypernatraemia	Hypernatraemia	NNP
cord-295807-68sukdb1	859	16	due	due	IN
cord-295807-68sukdb1	859	17	to	to	IN
cord-295807-68sukdb1	859	18	"	"	``
cord-295807-68sukdb1	859	19	Massive	massive	JJ
cord-295807-68sukdb1	859	20	"	"	''
cord-295807-68sukdb1	859	21	Sodium	Sodium	NNP
cord-295807-68sukdb1	859	22	Penicillin	Penicillin	NNP
cord-295807-68sukdb1	859	23	Therapy	Therapy	NNP
cord-295807-68sukdb1	859	24	Impaired	impair	VBD
cord-295807-68sukdb1	859	25	Renal	Renal	NNP
cord-295807-68sukdb1	859	26	HCO3-Excretion	HCO3-Excretion	NNP
cord-295807-68sukdb1	859	27	in	in	IN
cord-295807-68sukdb1	859	28	Cystic	Cystic	NNP
cord-295807-68sukdb1	859	29	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	859	30	Citrate	Citrate	NNP
cord-295807-68sukdb1	859	31	and	and	CC
cord-295807-68sukdb1	859	32	renal	renal	JJ
cord-295807-68sukdb1	859	33	calculi	calculus	NNS
cord-295807-68sukdb1	859	34	:	:	:
cord-295807-68sukdb1	859	35	an	an	DT
cord-295807-68sukdb1	859	36	update	update	NN
cord-295807-68sukdb1	859	37	Lemonade	Lemonade	NNP
cord-295807-68sukdb1	859	38	Therapy	Therapy	NNP
cord-295807-68sukdb1	859	39	Increases	increase	VBZ
cord-295807-68sukdb1	859	40	Urinary	Urinary	NNP
cord-295807-68sukdb1	859	41	Citrate	Citrate	NNP
cord-295807-68sukdb1	859	42	and	and	CC
cord-295807-68sukdb1	859	43	Urine	urine	NN
cord-295807-68sukdb1	859	44	Volumes	Volumes	NNPS
cord-295807-68sukdb1	859	45	in	in	IN
cord-295807-68sukdb1	859	46	Patients	patient	NNS
cord-295807-68sukdb1	859	47	with	with	IN
cord-295807-68sukdb1	859	48	Recurrent	Recurrent	NNP
cord-295807-68sukdb1	859	49	Calcium	Calcium	NNP
cord-295807-68sukdb1	859	50	Oxalate	Oxalate	NNP
cord-295807-68sukdb1	859	51	Stone	Stone	NNP
cord-295807-68sukdb1	859	52	Formation	Formation	NNP
cord-295807-68sukdb1	859	53	Long	long	JJ
cord-295807-68sukdb1	859	54	-	-	HYPH
cord-295807-68sukdb1	859	55	term	term	NN
cord-295807-68sukdb1	859	56	treatment	treatment	NN
cord-295807-68sukdb1	859	57	of	of	IN
cord-295807-68sukdb1	859	58	calcium	calcium	NN
cord-295807-68sukdb1	859	59	nephrolithiasis	nephrolithiasis	NN
cord-295807-68sukdb1	859	60	with	with	IN
cord-295807-68sukdb1	859	61	potassium	potassium	NN
cord-295807-68sukdb1	859	62	citrate	citrate	NNP
cord-295807-68sukdb1	859	63	Strategy	Strategy	NNP
cord-295807-68sukdb1	859	64	to	to	TO
cord-295807-68sukdb1	859	65	control	control	VB
cord-295807-68sukdb1	859	66	catheter	catheter	NN
cord-295807-68sukdb1	859	67	encrustation	encrustation	NN
cord-295807-68sukdb1	859	68	with	with	IN
cord-295807-68sukdb1	859	69	citrated	citrate	VBN
cord-295807-68sukdb1	859	70	drinks	drink	NNS
cord-295807-68sukdb1	859	71	:	:	:
cord-295807-68sukdb1	859	72	a	a	DT
cord-295807-68sukdb1	859	73	randomized	randomized	JJ
cord-295807-68sukdb1	859	74	crossover	crossover	NN
cord-295807-68sukdb1	859	75	study	study	NN
cord-295807-68sukdb1	859	76	Role	role	NN
cord-295807-68sukdb1	859	77	of	of	IN
cord-295807-68sukdb1	859	78	V	V	NNP
cord-295807-68sukdb1	859	79	-	-	HYPH
cord-295807-68sukdb1	859	80	ATPase	atpase	JJ
cord-295807-68sukdb1	859	81	-	-	HYPH
cord-295807-68sukdb1	859	82	rich	rich	JJ
cord-295807-68sukdb1	859	83	cells	cell	NNS
cord-295807-68sukdb1	859	84	in	in	IN
cord-295807-68sukdb1	859	85	acidification	acidification	NN
cord-295807-68sukdb1	859	86	of	of	IN
cord-295807-68sukdb1	859	87	the	the	DT
cord-295807-68sukdb1	859	88	male	male	JJ
cord-295807-68sukdb1	859	89	reproductive	reproductive	JJ
cord-295807-68sukdb1	859	90	tract	tract	NN
cord-295807-68sukdb1	860	1	The	the	DT
cord-295807-68sukdb1	860	2	activating	activate	VBG
cord-295807-68sukdb1	860	3	effects	effect	NNS
cord-295807-68sukdb1	860	4	of	of	IN
cord-295807-68sukdb1	860	5	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	860	6	on	on	IN
cord-295807-68sukdb1	860	7	sperm	sperm	NN
cord-295807-68sukdb1	860	8	motility	motility	NN
cord-295807-68sukdb1	860	9	and	and	CC
cord-295807-68sukdb1	860	10	respiration	respiration	NN
cord-295807-68sukdb1	860	11	at	at	IN
cord-295807-68sukdb1	860	12	ejaculation	ejaculation	NN
cord-295807-68sukdb1	860	13	Lowered	lower	VBN
cord-295807-68sukdb1	860	14	levels	level	NNS
cord-295807-68sukdb1	860	15	of	of	IN
cord-295807-68sukdb1	860	16	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	860	17	in	in	IN
cord-295807-68sukdb1	860	18	seminal	seminal	JJ
cord-295807-68sukdb1	860	19	plasma	plasma	NN
cord-295807-68sukdb1	860	20	cause	cause	NN
cord-295807-68sukdb1	861	1	the	the	DT
cord-295807-68sukdb1	861	2	poor	poor	JJ
cord-295807-68sukdb1	861	3	sperm	sperm	NN
cord-295807-68sukdb1	861	4	motility	motility	NN
cord-295807-68sukdb1	861	5	in	in	IN
cord-295807-68sukdb1	861	6	human	human	JJ
cord-295807-68sukdb1	861	7	infertile	infertile	JJ
cord-295807-68sukdb1	861	8	patients	patient	NNS
cord-295807-68sukdb1	861	9	Critical	critical	JJ
cord-295807-68sukdb1	861	10	role	role	NN
cord-295807-68sukdb1	861	11	of	of	IN
cord-295807-68sukdb1	861	12	CFTR	CFTR	NNP
cord-295807-68sukdb1	861	13	in	in	IN
cord-295807-68sukdb1	861	14	uterine	uterine	JJ
cord-295807-68sukdb1	861	15	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	861	16	secretion	secretion	NN
cord-295807-68sukdb1	861	17	and	and	CC
cord-295807-68sukdb1	861	18	the	the	DT
cord-295807-68sukdb1	861	19	fertilizing	fertilize	VBG
cord-295807-68sukdb1	861	20	capacity	capacity	NN
cord-295807-68sukdb1	861	21	of	of	IN
cord-295807-68sukdb1	861	22	sperm	sperm	NN
cord-295807-68sukdb1	861	23	A	a	DT
cord-295807-68sukdb1	861	24	new	new	JJ
cord-295807-68sukdb1	861	25	role	role	NN
cord-295807-68sukdb1	861	26	for	for	IN
cord-295807-68sukdb1	861	27	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	861	28	secretion	secretion	NN
cord-295807-68sukdb1	861	29	in	in	IN
cord-295807-68sukdb1	861	30	cervico	cervico	NN
cord-295807-68sukdb1	861	31	-	-	HYPH
cord-295807-68sukdb1	861	32	uterine	uterine	JJ
cord-295807-68sukdb1	861	33	mucus	mucus	NN
cord-295807-68sukdb1	861	34	release	release	NN
cord-295807-68sukdb1	861	35	Hydrogen	Hydrogen	NNP
cord-295807-68sukdb1	861	36	ion	ion	NN
cord-295807-68sukdb1	861	37	and	and	CC
cord-295807-68sukdb1	861	38	carbon	carbon	NN
cord-295807-68sukdb1	861	39	dioxide	dioxide	NN
cord-295807-68sukdb1	861	40	content	content	NN
cord-295807-68sukdb1	861	41	of	of	IN
cord-295807-68sukdb1	861	42	the	the	DT
cord-295807-68sukdb1	861	43	oviductal	oviductal	JJ
cord-295807-68sukdb1	861	44	fluid	fluid	NN
cord-295807-68sukdb1	861	45	of	of	IN
cord-295807-68sukdb1	861	46	the	the	DT
cord-295807-68sukdb1	861	47	rhesus	rhesus	NNP
cord-295807-68sukdb1	861	48	monkey	monkey	NN
cord-295807-68sukdb1	861	49	(	(	-LRB-
cord-295807-68sukdb1	861	50	Macaca	Macaca	NNP
cord-295807-68sukdb1	861	51	mulatta	mulatta	NN
cord-295807-68sukdb1	861	52	)	)	-RRB-
cord-295807-68sukdb1	862	1	Bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	862	2	is	be	VBZ
cord-295807-68sukdb1	862	3	essential	essential	JJ
cord-295807-68sukdb1	862	4	for	for	IN
cord-295807-68sukdb1	862	5	fertilization	fertilization	NN
cord-295807-68sukdb1	862	6	of	of	IN
cord-295807-68sukdb1	862	7	mouse	mouse	NN
cord-295807-68sukdb1	862	8	eggs	egg	NNS
cord-295807-68sukdb1	862	9	:	:	:
cord-295807-68sukdb1	862	10	mouse	mouse	NN
cord-295807-68sukdb1	862	11	sperm	sperm	NN
cord-295807-68sukdb1	862	12	require	require	VBP
cord-295807-68sukdb1	862	13	it	-PRON-	PRP
cord-295807-68sukdb1	862	14	to	to	TO
cord-295807-68sukdb1	862	15	undergo	undergo	VB
cord-295807-68sukdb1	862	16	the	the	DT
cord-295807-68sukdb1	862	17	acrosome	acrosome	NN
cord-295807-68sukdb1	862	18	reaction	reaction	NN
cord-295807-68sukdb1	862	19	Factors	factor	NNS
cord-295807-68sukdb1	862	20	and	and	CC
cord-295807-68sukdb1	862	21	pathways	pathway	NNS
cord-295807-68sukdb1	862	22	involved	involve	VBN
cord-295807-68sukdb1	862	23	in	in	IN
cord-295807-68sukdb1	862	24	capacitation	capacitation	NN
cord-295807-68sukdb1	862	25	:	:	:
cord-295807-68sukdb1	862	26	how	how	WRB
cord-295807-68sukdb1	862	27	are	be	VBP
cord-295807-68sukdb1	862	28	they	-PRON-	PRP
cord-295807-68sukdb1	862	29	regulated	regulate	VBN
cord-295807-68sukdb1	862	30	?	?	.
cord-295807-68sukdb1	863	1	Acidification	acidification	NN
cord-295807-68sukdb1	863	2	of	of	IN
cord-295807-68sukdb1	863	3	uterine	uterine	JJ
cord-295807-68sukdb1	863	4	epithelium	epithelium	NN
cord-295807-68sukdb1	863	5	during	during	IN
cord-295807-68sukdb1	863	6	embryo	embryo	NN
cord-295807-68sukdb1	863	7	implantation	implantation	NN
cord-295807-68sukdb1	863	8	in	in	IN
cord-295807-68sukdb1	863	9	mice	mouse	NNS
cord-295807-68sukdb1	863	10	Loss	Loss	NNP
cord-295807-68sukdb1	863	11	of	of	IN
cord-295807-68sukdb1	863	12	the	the	DT
cord-295807-68sukdb1	863	13	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	863	14	exchanger	exchanger	NN
cord-295807-68sukdb1	863	15	NHE8	NHE8	NNP
cord-295807-68sukdb1	863	16	causes	cause	VBZ
cord-295807-68sukdb1	863	17	male	male	JJ
cord-295807-68sukdb1	863	18	infertility	infertility	NN
cord-295807-68sukdb1	863	19	in	in	IN
cord-295807-68sukdb1	863	20	mice	mouse	NNS
cord-295807-68sukdb1	863	21	by	by	IN
cord-295807-68sukdb1	863	22	disrupting	disrupt	VBG
cord-295807-68sukdb1	863	23	acrosome	acrosome	NNP
cord-295807-68sukdb1	863	24	formation	formation	NN
cord-295807-68sukdb1	863	25	Disruption	disruption	NN
cord-295807-68sukdb1	863	26	of	of	IN
cord-295807-68sukdb1	863	27	the	the	DT
cord-295807-68sukdb1	863	28	SLC26A3-mediated	slc26a3-mediated	JJ
cord-295807-68sukdb1	863	29	anion	anion	NN
cord-295807-68sukdb1	863	30	transport	transport	NN
cord-295807-68sukdb1	863	31	is	be	VBZ
cord-295807-68sukdb1	863	32	associated	associate	VBN
cord-295807-68sukdb1	863	33	with	with	IN
cord-295807-68sukdb1	863	34	male	male	JJ
cord-295807-68sukdb1	863	35	subfertility	subfertility	NN
cord-295807-68sukdb1	863	36	Anion	Anion	NNP
cord-295807-68sukdb1	863	37	exchanger	exchanger	NN
cord-295807-68sukdb1	863	38	2	2	CD
cord-295807-68sukdb1	863	39	is	be	VBZ
cord-295807-68sukdb1	863	40	essential	essential	JJ
cord-295807-68sukdb1	863	41	for	for	IN
cord-295807-68sukdb1	863	42	spermiogenesis	spermiogenesis	NN
cord-295807-68sukdb1	863	43	in	in	IN
cord-295807-68sukdb1	863	44	mice	mice	NN
cord-295807-68sukdb1	863	45	Tests	test	NNS
cord-295807-68sukdb1	863	46	of	of	IN
cord-295807-68sukdb1	863	47	Buffergel	Buffergel	NNP
cord-295807-68sukdb1	863	48	for	for	IN
cord-295807-68sukdb1	863	49	contraception	contraception	NN
cord-295807-68sukdb1	863	50	and	and	CC
cord-295807-68sukdb1	863	51	prevention	prevention	NN
cord-295807-68sukdb1	863	52	of	of	IN
cord-295807-68sukdb1	863	53	sexually	sexually	RB
cord-295807-68sukdb1	863	54	transmitted	transmit	VBN
cord-295807-68sukdb1	863	55	diseases	disease	NNS
cord-295807-68sukdb1	863	56	in	in	IN
cord-295807-68sukdb1	863	57	animal	animal	NN
cord-295807-68sukdb1	863	58	models	model	NNS
cord-295807-68sukdb1	864	1	Maternal	maternal	JJ
cord-295807-68sukdb1	864	2	and	and	CC
cord-295807-68sukdb1	864	3	Fetal	fetal	JJ
cord-295807-68sukdb1	864	4	Acid	acid	NN
cord-295807-68sukdb1	864	5	-	-	HYPH
cord-295807-68sukdb1	864	6	Base	base	NN
cord-295807-68sukdb1	864	7	Chemistry	chemistry	NN
cord-295807-68sukdb1	864	8	:	:	:
cord-295807-68sukdb1	865	1	A	a	DT
cord-295807-68sukdb1	865	2	Major	major	JJ
cord-295807-68sukdb1	865	3	Determinant	determinant	NN
cord-295807-68sukdb1	865	4	of	of	IN
cord-295807-68sukdb1	865	5	Perinatal	Perinatal	NNP
cord-295807-68sukdb1	865	6	Outcome	Outcome	NNP
cord-295807-68sukdb1	865	7	Effect	effect	NN
cord-295807-68sukdb1	865	8	of	of	IN
cord-295807-68sukdb1	865	9	preoperative	preoperative	JJ
cord-295807-68sukdb1	865	10	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	865	11	infusion	infusion	NN
cord-295807-68sukdb1	865	12	on	on	IN
cord-295807-68sukdb1	865	13	maternal	maternal	JJ
cord-295807-68sukdb1	865	14	and	and	CC
cord-295807-68sukdb1	865	15	perinatal	perinatal	JJ
cord-295807-68sukdb1	865	16	outcomes	outcome	NNS
cord-295807-68sukdb1	865	17	of	of	IN
cord-295807-68sukdb1	865	18	obstructed	obstruct	VBN
cord-295807-68sukdb1	865	19	labour	labour	NN
cord-295807-68sukdb1	865	20	in	in	IN
cord-295807-68sukdb1	865	21	Mbale	Mbale	NNP
cord-295807-68sukdb1	865	22	Regional	Regional	NNP
cord-295807-68sukdb1	865	23	Referral	Referral	NNP
cord-295807-68sukdb1	865	24	Hospital	Hospital	NNP
cord-295807-68sukdb1	865	25	:	:	:
cord-295807-68sukdb1	865	26	a	a	DT
cord-295807-68sukdb1	865	27	study	study	NN
cord-295807-68sukdb1	865	28	protocol	protocol	NN
cord-295807-68sukdb1	865	29	for	for	IN
cord-295807-68sukdb1	865	30	a	a	DT
cord-295807-68sukdb1	865	31	randomised	randomised	JJ
cord-295807-68sukdb1	865	32	controlled	control	VBN
cord-295807-68sukdb1	865	33	trial	trial	NN
cord-295807-68sukdb1	865	34	Improvement	improvement	NN
cord-295807-68sukdb1	865	35	of	of	IN
cord-295807-68sukdb1	865	36	cervical	cervical	JJ
cord-295807-68sukdb1	865	37	mucus	mucus	NN
cord-295807-68sukdb1	865	38	viscoelasticity	viscoelasticity	NN
cord-295807-68sukdb1	865	39	and	and	CC
cord-295807-68sukdb1	865	40	sperm	sperm	NN
cord-295807-68sukdb1	865	41	penetration	penetration	NN
cord-295807-68sukdb1	865	42	with	with	IN
cord-295807-68sukdb1	865	43	sodium	sodium	NN
cord-295807-68sukdb1	865	44	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	865	45	douching	douche	VBG
cord-295807-68sukdb1	865	46	Sodium	sodium	NN
cord-295807-68sukdb1	865	47	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	865	48	douching	douche	VBG
cord-295807-68sukdb1	865	49	for	for	IN
cord-295807-68sukdb1	865	50	improvement	improvement	NN
cord-295807-68sukdb1	865	51	of	of	IN
cord-295807-68sukdb1	865	52	the	the	DT
cord-295807-68sukdb1	865	53	postcoital	postcoital	JJ
cord-295807-68sukdb1	865	54	test	test	NN
cord-295807-68sukdb1	865	55	Spermicidal	spermicidal	JJ
cord-295807-68sukdb1	865	56	effects	effect	NNS
cord-295807-68sukdb1	865	57	of	of	IN
cord-295807-68sukdb1	865	58	lemon	lemon	NN
cord-295807-68sukdb1	865	59	juice	juice	NN
cord-295807-68sukdb1	865	60	and	and	CC
cord-295807-68sukdb1	865	61	juices	juice	NNS
cord-295807-68sukdb1	865	62	from	from	IN
cord-295807-68sukdb1	865	63	other	other	JJ
cord-295807-68sukdb1	865	64	natural	natural	JJ
cord-295807-68sukdb1	865	65	products	product	NNS
cord-295807-68sukdb1	865	66	,	,	,
cord-295807-68sukdb1	865	67	Agriculture	Agriculture	NNP
cord-295807-68sukdb1	865	68	and	and	CC
cord-295807-68sukdb1	865	69	Natural	Natural	NNP
cord-295807-68sukdb1	865	70	Resources	Resources	NNPS
cord-295807-68sukdb1	866	1	ACIDFORM	ACIDFORM	NNS
cord-295807-68sukdb1	866	2	:	:	:
cord-295807-68sukdb1	866	3	a	a	DT
cord-295807-68sukdb1	866	4	review	review	NN
cord-295807-68sukdb1	866	5	of	of	IN
cord-295807-68sukdb1	866	6	the	the	DT
cord-295807-68sukdb1	866	7	evidence	evidence	NN
cord-295807-68sukdb1	866	8	A	a	DT
cord-295807-68sukdb1	866	9	novel	novel	JJ
cord-295807-68sukdb1	866	10	vaginal	vaginal	JJ
cord-295807-68sukdb1	866	11	pH	ph	NN
cord-295807-68sukdb1	866	12	regulator	regulator	NN
cord-295807-68sukdb1	866	13	:	:	:
cord-295807-68sukdb1	867	1	results	result	NNS
cord-295807-68sukdb1	867	2	from	from	IN
cord-295807-68sukdb1	867	3	the	the	DT
cord-295807-68sukdb1	867	4	phase	phase	NN
cord-295807-68sukdb1	867	5	3	3	CD
cord-295807-68sukdb1	867	6	AMPOWER	AMPOWER	NNP
cord-295807-68sukdb1	867	7	contraception	contraception	NN
cord-295807-68sukdb1	867	8	clinical	clinical	JJ
cord-295807-68sukdb1	867	9	trial	trial	NN
cord-295807-68sukdb1	867	10	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	867	11	ion	ion	NN
cord-295807-68sukdb1	867	12	;	;	:
cord-295807-68sukdb1	867	13	the	the	DT
cord-295807-68sukdb1	867	14	corona	corona	NN
cord-295807-68sukdb1	867	15	cell	cell	NN
cord-295807-68sukdb1	867	16	dispersing	disperse	VBG
cord-295807-68sukdb1	867	17	factor	factor	NN
cord-295807-68sukdb1	867	18	of	of	IN
cord-295807-68sukdb1	867	19	rabbit	rabbit	NN
cord-295807-68sukdb1	867	20	tubal	tubal	NN
cord-295807-68sukdb1	867	21	fluid	fluid	NN
cord-295807-68sukdb1	867	22	Pantoprazole	Pantoprazole	NNP
cord-295807-68sukdb1	867	23	,	,	,
cord-295807-68sukdb1	867	24	a	a	DT
cord-295807-68sukdb1	867	25	proton	proton	NN
cord-295807-68sukdb1	867	26	-	-	HYPH
cord-295807-68sukdb1	867	27	pump	pump	NN
cord-295807-68sukdb1	867	28	inhibitor	inhibitor	NN
cord-295807-68sukdb1	867	29	,	,	,
cord-295807-68sukdb1	867	30	impairs	impair	VBZ
cord-295807-68sukdb1	867	31	human	human	JJ
cord-295807-68sukdb1	867	32	sperm	sperm	NN
cord-295807-68sukdb1	867	33	motility	motility	NN
cord-295807-68sukdb1	867	34	and	and	CC
cord-295807-68sukdb1	867	35	capacitation	capacitation	NN
cord-295807-68sukdb1	867	36	in	in	IN
cord-295807-68sukdb1	867	37	vitro	vitro	FW
cord-295807-68sukdb1	867	38	Acid	acid	NN
cord-295807-68sukdb1	867	39	-	-	HYPH
cord-295807-68sukdb1	867	40	base	base	NN
cord-295807-68sukdb1	867	41	disorders	disorder	NNS
cord-295807-68sukdb1	867	42	in	in	IN
cord-295807-68sukdb1	867	43	liver	liver	NN
cord-295807-68sukdb1	867	44	disease	disease	NN
cord-295807-68sukdb1	867	45	Effect	effect	NN
cord-295807-68sukdb1	867	46	of	of	IN
cord-295807-68sukdb1	867	47	pH	pH	NNP
cord-295807-68sukdb1	867	48	on	on	IN
cord-295807-68sukdb1	867	49	the	the	DT
cord-295807-68sukdb1	867	50	kinetics	kinetic	NNS
cord-295807-68sukdb1	867	51	of	of	IN
cord-295807-68sukdb1	867	52	frog	frog	NN
cord-295807-68sukdb1	867	53	muscle	muscle	NN
cord-295807-68sukdb1	867	54	phosphofructokinase	phosphofructokinase	NNP
cord-295807-68sukdb1	867	55	Inhibition	Inhibition	NNP
cord-295807-68sukdb1	867	56	by	by	IN
cord-295807-68sukdb1	867	57	acidosis	acidosis	NN
cord-295807-68sukdb1	867	58	of	of	IN
cord-295807-68sukdb1	867	59	adenosine	adenosine	NN
cord-295807-68sukdb1	867	60	3',5'-cyclic	3',5'-cyclic	CD
cord-295807-68sukdb1	867	61	monophosphate	monophosphate	NN
cord-295807-68sukdb1	867	62	accumulation	accumulation	NN
cord-295807-68sukdb1	867	63	and	and	CC
cord-295807-68sukdb1	867	64	lipolysis	lipolysis	NN
cord-295807-68sukdb1	867	65	in	in	IN
cord-295807-68sukdb1	867	66	isolated	isolate	VBN
cord-295807-68sukdb1	867	67	rat	rat	NN
cord-295807-68sukdb1	867	68	fat	fat	NN
cord-295807-68sukdb1	867	69	cells	cell	NNS
cord-295807-68sukdb1	867	70	Bicarbonate	bicarbonate	JJ
cord-295807-68sukdb1	867	71	in	in	IN
cord-295807-68sukdb1	867	72	the	the	DT
cord-295807-68sukdb1	867	73	treatment	treatment	NN
cord-295807-68sukdb1	867	74	of	of	IN
cord-295807-68sukdb1	867	75	metabolic	metabolic	JJ
cord-295807-68sukdb1	867	76	acidosis	acidosis	NN
cord-295807-68sukdb1	867	77	:	:	:
cord-295807-68sukdb1	867	78	effects	effect	NNS
cord-295807-68sukdb1	867	79	on	on	IN
cord-295807-68sukdb1	867	80	hepatic	hepatic	JJ
cord-295807-68sukdb1	867	81	intracellular	intracellular	JJ
cord-295807-68sukdb1	867	82	pH	ph	NN
cord-295807-68sukdb1	867	83	,	,	,
cord-295807-68sukdb1	867	84	gluconeogenesis	gluconeogenesis	NN
cord-295807-68sukdb1	867	85	,	,	,
cord-295807-68sukdb1	867	86	and	and	CC
cord-295807-68sukdb1	867	87	lactate	lactate	NN
cord-295807-68sukdb1	867	88	disposal	disposal	NN
cord-295807-68sukdb1	867	89	in	in	IN
cord-295807-68sukdb1	867	90	rats	rat	NNS
cord-295807-68sukdb1	867	91	Renal	renal	JJ
cord-295807-68sukdb1	867	92	gluconeogenesis	gluconeogenesis	NN
cord-295807-68sukdb1	867	93	in	in	IN
cord-295807-68sukdb1	867	94	acidosis	acidosis	NN
cord-295807-68sukdb1	867	95	,	,	,
cord-295807-68sukdb1	867	96	alkalosis	alkalosis	NN
cord-295807-68sukdb1	867	97	,	,	,
cord-295807-68sukdb1	867	98	and	and	CC
cord-295807-68sukdb1	867	99	potassium	potassium	NN
cord-295807-68sukdb1	867	100	deficiency	deficiency	NN
cord-295807-68sukdb1	867	101	:	:	:
cord-295807-68sukdb1	868	1	its	-PRON-	PRP$
cord-295807-68sukdb1	868	2	possible	possible	JJ
cord-295807-68sukdb1	868	3	role	role	NN
cord-295807-68sukdb1	868	4	in	in	IN
cord-295807-68sukdb1	868	5	regulation	regulation	NN
cord-295807-68sukdb1	868	6	of	of	IN
cord-295807-68sukdb1	868	7	renal	renal	JJ
cord-295807-68sukdb1	868	8	ammonia	ammonia	NN
cord-295807-68sukdb1	868	9	production	production	NN
cord-295807-68sukdb1	868	10	Effect	effect	NN
cord-295807-68sukdb1	868	11	of	of	IN
cord-295807-68sukdb1	868	12	extracellular	extracellular	JJ
cord-295807-68sukdb1	868	13	pH	ph	NN
cord-295807-68sukdb1	868	14	on	on	IN
cord-295807-68sukdb1	868	15	insulin	insulin	NN
cord-295807-68sukdb1	868	16	secretion	secretion	NN
cord-295807-68sukdb1	868	17	and	and	CC
cord-295807-68sukdb1	868	18	glucose	glucose	NN
cord-295807-68sukdb1	868	19	metabolism	metabolism	NN
cord-295807-68sukdb1	868	20	in	in	IN
cord-295807-68sukdb1	868	21	neonatal	neonatal	JJ
cord-295807-68sukdb1	868	22	and	and	CC
cord-295807-68sukdb1	868	23	adult	adult	NN
cord-295807-68sukdb1	868	24	rat	rat	NN
cord-295807-68sukdb1	868	25	pancreatic	pancreatic	NN
cord-295807-68sukdb1	868	26	islets	islet	NNS
cord-295807-68sukdb1	869	1	A	a	DT
cord-295807-68sukdb1	869	2	physiological	physiological	JJ
cord-295807-68sukdb1	869	3	solvent	solvent	NN
cord-295807-68sukdb1	869	4	for	for	IN
cord-295807-68sukdb1	869	5	crystalline	crystalline	JJ
cord-295807-68sukdb1	869	6	insulin	insulin	NN
cord-295807-68sukdb1	869	7	Insulin	Insulin	NNP
cord-295807-68sukdb1	869	8	Sensitivity	Sensitivity	NNP
cord-295807-68sukdb1	869	9	and	and	CC
cord-295807-68sukdb1	869	10	Glucose	Glucose	NNP
cord-295807-68sukdb1	869	11	Homeostasis	homeostasis	NN
cord-295807-68sukdb1	869	12	Can	Can	MD
cord-295807-68sukdb1	869	13	Be	be	VB
cord-295807-68sukdb1	869	14	Influenced	influence	VBN
cord-295807-68sukdb1	869	15	by	by	IN
cord-295807-68sukdb1	869	16	Metabolic	Metabolic	NNP
cord-295807-68sukdb1	869	17	Acid	Acid	NNP
cord-295807-68sukdb1	869	18	Load	Load	NNP
cord-295807-68sukdb1	869	19	Dietary	dietary	JJ
cord-295807-68sukdb1	869	20	acid	acid	NN
cord-295807-68sukdb1	869	21	load	load	NN
cord-295807-68sukdb1	869	22	,	,	,
cord-295807-68sukdb1	869	23	metabolic	metabolic	JJ
cord-295807-68sukdb1	869	24	acidosis	acidosis	NN
cord-295807-68sukdb1	869	25	and	and	CC
cord-295807-68sukdb1	869	26	insulin	insulin	NN
cord-295807-68sukdb1	869	27	resistance	resistance	NN
cord-295807-68sukdb1	869	28	-Lessons	-Lessons	:
cord-295807-68sukdb1	869	29	from	from	IN
cord-295807-68sukdb1	869	30	cross	cross	JJ
cord-295807-68sukdb1	869	31	-	-	JJ
cord-295807-68sukdb1	869	32	sectional	sectional	JJ
cord-295807-68sukdb1	869	33	and	and	CC
cord-295807-68sukdb1	869	34	overfeeding	overfeeding	JJ
cord-295807-68sukdb1	869	35	studies	study	NNS
cord-295807-68sukdb1	869	36	in	in	IN
cord-295807-68sukdb1	869	37	humans	human	NNS
cord-295807-68sukdb1	870	1	The	the	DT
cord-295807-68sukdb1	870	2	pH	pH	NNP
cord-295807-68sukdb1	870	3	dependence	dependence	NN
cord-295807-68sukdb1	870	4	of	of	IN
cord-295807-68sukdb1	870	5	insulin	insulin	NN
cord-295807-68sukdb1	870	6	binding	binding	NN
cord-295807-68sukdb1	870	7	.	.	.
cord-295807-68sukdb1	871	1	A	a	DT
cord-295807-68sukdb1	871	2	quantitative	quantitative	JJ
cord-295807-68sukdb1	871	3	study	study	NN
cord-295807-68sukdb1	871	4	Stimulatory	stimulatory	JJ
cord-295807-68sukdb1	871	5	effect	effect	NN
cord-295807-68sukdb1	871	6	of	of	IN
cord-295807-68sukdb1	871	7	insulin	insulin	NN
cord-295807-68sukdb1	871	8	on	on	IN
cord-295807-68sukdb1	871	9	renal	renal	JJ
cord-295807-68sukdb1	871	10	proximal	proximal	JJ
cord-295807-68sukdb1	871	11	tubule	tubule	NN
cord-295807-68sukdb1	871	12	sodium	sodium	NN
cord-295807-68sukdb1	871	13	transport	transport	NN
cord-295807-68sukdb1	871	14	is	be	VBZ
cord-295807-68sukdb1	871	15	preserved	preserve	VBN
cord-295807-68sukdb1	871	16	in	in	IN
cord-295807-68sukdb1	871	17	type	type	NN
cord-295807-68sukdb1	871	18	2	2	CD
cord-295807-68sukdb1	871	19	diabetes	diabetes	NN
cord-295807-68sukdb1	871	20	with	with	IN
cord-295807-68sukdb1	871	21	nephropathy	nephropathy	NN
cord-295807-68sukdb1	871	22	Molecular	Molecular	NNP
cord-295807-68sukdb1	871	23	Mechanism	Mechanism	NNP
cord-295807-68sukdb1	871	24	of	of	IN
cord-295807-68sukdb1	871	25	Pancreatic	pancreatic	NN
cord-295807-68sukdb1	871	26	and	and	CC
cord-295807-68sukdb1	871	27	Salivary	Salivary	NNP
cord-295807-68sukdb1	871	28	Glands	gland	NNS
cord-295807-68sukdb1	871	29	Fluid	Fluid	NNP
cord-295807-68sukdb1	871	30	and	and	CC
cord-295807-68sukdb1	871	31	HCO3−	HCO3−	NNP
cord-295807-68sukdb1	871	32	Secretion	Secretion	NNP
cord-295807-68sukdb1	871	33	Effect	Effect	NNP
cord-295807-68sukdb1	871	34	of	of	IN
cord-295807-68sukdb1	871	35	mineralocorticoids	mineralocorticoid	NNS
cord-295807-68sukdb1	871	36	on	on	IN
cord-295807-68sukdb1	871	37	acid	acid	NN
cord-295807-68sukdb1	871	38	-	-	HYPH
cord-295807-68sukdb1	871	39	base	base	NN
cord-295807-68sukdb1	871	40	balance	balance	NN
cord-295807-68sukdb1	871	41	Bartter	Bartter	NNP
cord-295807-68sukdb1	871	42	or	or	CC
cord-295807-68sukdb1	871	43	Gitelman	Gitelman	NNP
cord-295807-68sukdb1	871	44	-	-	HYPH
cord-295807-68sukdb1	871	45	how	how	WRB
cord-295807-68sukdb1	871	46	to	to	TO
cord-295807-68sukdb1	871	47	differentiate	differentiate	VB
cord-295807-68sukdb1	871	48	?	?	.
cord-295807-68sukdb1	872	1	Acid	acid	JJ
cord-295807-68sukdb1	872	2	retention	retention	NN
cord-295807-68sukdb1	872	3	during	during	IN
cord-295807-68sukdb1	872	4	kidney	kidney	NN
cord-295807-68sukdb1	872	5	failure	failure	NN
cord-295807-68sukdb1	872	6	induces	induce	VBZ
cord-295807-68sukdb1	872	7	endothelin	endothelin	NNP
cord-295807-68sukdb1	872	8	and	and	CC
cord-295807-68sukdb1	872	9	aldosterone	aldosterone	NN
cord-295807-68sukdb1	872	10	production	production	NN
cord-295807-68sukdb1	872	11	which	which	WDT
cord-295807-68sukdb1	872	12	lead	lead	VBP
cord-295807-68sukdb1	872	13	to	to	IN
cord-295807-68sukdb1	872	14	progressive	progressive	JJ
cord-295807-68sukdb1	872	15	GFR	GFR	NNP
cord-295807-68sukdb1	872	16	decline	decline	NN
cord-295807-68sukdb1	872	17	,	,	,
cord-295807-68sukdb1	872	18	a	a	DT
cord-295807-68sukdb1	872	19	situation	situation	NN
cord-295807-68sukdb1	872	20	ameliorated	ameliorate	VBN
cord-295807-68sukdb1	872	21	by	by	IN
cord-295807-68sukdb1	872	22	alkali	alkali	NN
cord-295807-68sukdb1	872	23	diet	diet	NN
cord-295807-68sukdb1	872	24	Role	role	NN
cord-295807-68sukdb1	872	25	of	of	IN
cord-295807-68sukdb1	872	26	endothelin-1	endothelin-1	NNP
cord-295807-68sukdb1	872	27	in	in	IN
cord-295807-68sukdb1	872	28	renal	renal	JJ
cord-295807-68sukdb1	872	29	regulation	regulation	NN
cord-295807-68sukdb1	872	30	of	of	IN
cord-295807-68sukdb1	872	31	acidbase	acidbase	NN
cord-295807-68sukdb1	872	32	equilibrium	equilibrium	NN
cord-295807-68sukdb1	872	33	in	in	IN
cord-295807-68sukdb1	872	34	acidotic	acidotic	JJ
cord-295807-68sukdb1	872	35	humans	human	NNS
cord-295807-68sukdb1	872	36	Higher	higher	RBR
cord-295807-68sukdb1	872	37	dietdependent	dietdependent	JJ
cord-295807-68sukdb1	872	38	renal	renal	JJ
cord-295807-68sukdb1	872	39	acid	acid	NN
cord-295807-68sukdb1	872	40	load	load	NN
cord-295807-68sukdb1	872	41	associates	associate	NNS
cord-295807-68sukdb1	872	42	with	with	IN
cord-295807-68sukdb1	872	43	higher	high	JJR
cord-295807-68sukdb1	872	44	glucocorticoid	glucocorticoid	NN
cord-295807-68sukdb1	872	45	secretion	secretion	NN
cord-295807-68sukdb1	872	46	and	and	CC
cord-295807-68sukdb1	872	47	potentially	potentially	RB
cord-295807-68sukdb1	872	48	bioactive	bioactive	JJ
cord-295807-68sukdb1	872	49	free	free	JJ
cord-295807-68sukdb1	872	50	glucocorticoids	glucocorticoid	NNS
cord-295807-68sukdb1	872	51	in	in	IN
cord-295807-68sukdb1	872	52	healthy	healthy	JJ
cord-295807-68sukdb1	872	53	children	child	NNS
cord-295807-68sukdb1	872	54	Effect	effect	NN
cord-295807-68sukdb1	872	55	of	of	IN
cord-295807-68sukdb1	872	56	chronic	chronic	JJ
cord-295807-68sukdb1	872	57	metabolic	metabolic	JJ
cord-295807-68sukdb1	872	58	acidosis	acidosis	NN
cord-295807-68sukdb1	872	59	on	on	IN
cord-295807-68sukdb1	872	60	the	the	DT
cord-295807-68sukdb1	872	61	growth	growth	NN
cord-295807-68sukdb1	872	62	hormone	hormone	NN
cord-295807-68sukdb1	872	63	/	/	SYM
cord-295807-68sukdb1	872	64	IGF-1	IGF-1	NNP
cord-295807-68sukdb1	872	65	endocrine	endocrine	JJ
cord-295807-68sukdb1	872	66	axis	axis	NN
cord-295807-68sukdb1	872	67	:	:	:
cord-295807-68sukdb1	872	68	New	new	JJ
cord-295807-68sukdb1	872	69	cause	cause	NN
cord-295807-68sukdb1	872	70	of	of	IN
cord-295807-68sukdb1	872	71	growth	growth	NN
cord-295807-68sukdb1	872	72	hormone	hormone	NN
cord-295807-68sukdb1	872	73	insensitivity	insensitivity	NN
cord-295807-68sukdb1	872	74	in	in	IN
cord-295807-68sukdb1	872	75	humans	human	NNS
cord-295807-68sukdb1	873	1	In	in	IN
cord-295807-68sukdb1	873	2	vivo	vivo	NN
cord-295807-68sukdb1	873	3	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	873	4	deficiency	deficiency	NN
cord-295807-68sukdb1	873	5	and	and	CC
cord-295807-68sukdb1	873	6	insulin	insulin	NN
cord-295807-68sukdb1	873	7	dissolution	dissolution	NN
cord-295807-68sukdb1	874	1	Combined	combine	VBN
cord-295807-68sukdb1	874	2	Insulin	Insulin	NNP
cord-295807-68sukdb1	874	3	and	and	CC
cord-295807-68sukdb1	874	4	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	874	5	Therapy	Therapy	NNP
cord-295807-68sukdb1	874	6	Elicits	elicit	VBZ
cord-295807-68sukdb1	874	7	Cerebral	cerebral	JJ
cord-295807-68sukdb1	874	8	Edema	edema	NN
cord-295807-68sukdb1	874	9	in	in	IN
cord-295807-68sukdb1	874	10	a	a	DT
cord-295807-68sukdb1	874	11	Juvenile	Juvenile	NNP
cord-295807-68sukdb1	874	12	Mouse	Mouse	NNP
cord-295807-68sukdb1	874	13	Model	Model	NNP
cord-295807-68sukdb1	874	14	of	of	IN
cord-295807-68sukdb1	874	15	Diabetic	Diabetic	NNP
cord-295807-68sukdb1	874	16	Ketoacidosis	Ketoacidosis	NNP
cord-295807-68sukdb1	874	17	Intracellular	Intracellular	NNP
cord-295807-68sukdb1	874	18	pH	ph	NN
cord-295807-68sukdb1	874	19	regulation	regulation	NN
cord-295807-68sukdb1	874	20	during	during	IN
cord-295807-68sukdb1	874	21	spreading	spread	VBG
cord-295807-68sukdb1	874	22	of	of	IN
cord-295807-68sukdb1	874	23	human	human	JJ
cord-295807-68sukdb1	874	24	neutrophils	neutrophil	NNS
cord-295807-68sukdb1	875	1	Extracellular	Extracellular	NNP
cord-295807-68sukdb1	875	2	Acidosis	acidosis	NN
cord-295807-68sukdb1	875	3	Is	be	VBZ
cord-295807-68sukdb1	875	4	a	a	DT
cord-295807-68sukdb1	875	5	Novel	Novel	NNP
cord-295807-68sukdb1	875	6	Danger	Danger	NNP
cord-295807-68sukdb1	875	7	Signal	Signal	NNP
cord-295807-68sukdb1	875	8	Alerting	alert	VBG
cord-295807-68sukdb1	875	9	Innate	Innate	NNP
cord-295807-68sukdb1	875	10	Immunity	Immunity	NNP
cord-295807-68sukdb1	875	11	via	via	IN
cord-295807-68sukdb1	875	12	the	the	DT
cord-295807-68sukdb1	875	13	NLRP3	nlrp3	NN
cord-295807-68sukdb1	875	14	Inflammasome	Inflammasome	NNP
cord-295807-68sukdb1	876	1	The	the	DT
cord-295807-68sukdb1	876	2	intimate	intimate	JJ
cord-295807-68sukdb1	876	3	and	and	CC
cord-295807-68sukdb1	876	4	controversial	controversial	JJ
cord-295807-68sukdb1	876	5	relationship	relationship	NN
cord-295807-68sukdb1	876	6	between	between	IN
cord-295807-68sukdb1	876	7	voltage	voltage	NN
cord-295807-68sukdb1	876	8	-	-	HYPH
cord-295807-68sukdb1	876	9	gated	gate	VBN
cord-295807-68sukdb1	876	10	proton	proton	NN
cord-295807-68sukdb1	876	11	channels	channel	NNS
cord-295807-68sukdb1	876	12	and	and	CC
cord-295807-68sukdb1	876	13	the	the	DT
cord-295807-68sukdb1	876	14	phagocyte	phagocyte	NNP
cord-295807-68sukdb1	876	15	NADPH	NADPH	NNP
cord-295807-68sukdb1	876	16	oxidase	oxidase	NN
cord-295807-68sukdb1	876	17	Voltage	voltage	NN
cord-295807-68sukdb1	876	18	-	-	HYPH
cord-295807-68sukdb1	876	19	gated	gate	VBN
cord-295807-68sukdb1	876	20	proton	proton	NN
cord-295807-68sukdb1	876	21	channels	channel	NNS
cord-295807-68sukdb1	876	22	maintain	maintain	VBP
cord-295807-68sukdb1	876	23	pH	ph	NN
cord-295807-68sukdb1	876	24	in	in	IN
cord-295807-68sukdb1	876	25	human	human	JJ
cord-295807-68sukdb1	876	26	neutrophils	neutrophil	NNS
cord-295807-68sukdb1	876	27	during	during	IN
cord-295807-68sukdb1	876	28	phagocytosis	phagocytosis	NN
cord-295807-68sukdb1	876	29	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	876	30	exchange	exchange	NN
cord-295807-68sukdb1	876	31	activity	activity	NN
cord-295807-68sukdb1	876	32	during	during	IN
cord-295807-68sukdb1	876	33	phagocytosis	phagocytosis	NN
cord-295807-68sukdb1	876	34	in	in	IN
cord-295807-68sukdb1	876	35	human	human	JJ
cord-295807-68sukdb1	876	36	neutrophils	neutrophil	NNS
cord-295807-68sukdb1	876	37	:	:	:
cord-295807-68sukdb1	876	38	role	role	NN
cord-295807-68sukdb1	876	39	of	of	IN
cord-295807-68sukdb1	876	40	Fcgamma	Fcgamma	NNP
cord-295807-68sukdb1	876	41	receptors	receptor	NNS
cord-295807-68sukdb1	876	42	and	and	CC
cord-295807-68sukdb1	876	43	tyrosine	tyrosine	NN
cord-295807-68sukdb1	876	44	kinases	kinase	NNS
cord-295807-68sukdb1	876	45	Science	Science	NNP
cord-295807-68sukdb1	876	46	review	review	NN
cord-295807-68sukdb1	876	47	:	:	:
cord-295807-68sukdb1	877	1	Extracellular	extracellular	JJ
cord-295807-68sukdb1	877	2	acidosis	acidosis	NN
cord-295807-68sukdb1	877	3	and	and	CC
cord-295807-68sukdb1	877	4	the	the	DT
cord-295807-68sukdb1	877	5	immune	immune	JJ
cord-295807-68sukdb1	877	6	response	response	NN
cord-295807-68sukdb1	877	7	:	:	:
cord-295807-68sukdb1	877	8	clinical	clinical	JJ
cord-295807-68sukdb1	877	9	and	and	CC
cord-295807-68sukdb1	877	10	physiologic	physiologic	JJ
cord-295807-68sukdb1	877	11	implications	implication	NNS
cord-295807-68sukdb1	878	1	The	the	DT
cord-295807-68sukdb1	878	2	effect	effect	NN
cord-295807-68sukdb1	878	3	of	of	IN
cord-295807-68sukdb1	878	4	pH	ph	NN
cord-295807-68sukdb1	878	5	and	and	CC
cord-295807-68sukdb1	878	6	nucleophiles	nucleophile	NNS
cord-295807-68sukdb1	878	7	on	on	IN
cord-295807-68sukdb1	878	8	complement	complement	JJ
cord-295807-68sukdb1	878	9	activation	activation	NN
cord-295807-68sukdb1	878	10	by	by	IN
cord-295807-68sukdb1	878	11	human	human	JJ
cord-295807-68sukdb1	878	12	proximal	proximal	JJ
cord-295807-68sukdb1	878	13	tubular	tubular	JJ
cord-295807-68sukdb1	878	14	epithelial	epithelial	JJ
cord-295807-68sukdb1	878	15	cells	cell	NNS
cord-295807-68sukdb1	878	16	Unravelling	unravel	VBG
cord-295807-68sukdb1	878	17	the	the	DT
cord-295807-68sukdb1	878	18	Interplay	interplay	NN
cord-295807-68sukdb1	878	19	between	between	IN
cord-295807-68sukdb1	878	20	Extracellular	Extracellular	NNP
cord-295807-68sukdb1	878	21	Acidosis	Acidosis	NNP
cord-295807-68sukdb1	878	22	and	and	CC
cord-295807-68sukdb1	878	23	Immune	Immune	NNP
cord-295807-68sukdb1	878	24	Cells	Cells	NNPS
cord-295807-68sukdb1	878	25	Acute	acute	JJ
cord-295807-68sukdb1	878	26	asphyxia	asphyxia	NN
cord-295807-68sukdb1	878	27	affects	affect	VBZ
cord-295807-68sukdb1	878	28	neutrophil	neutrophil	NN
cord-295807-68sukdb1	878	29	number	number	NN
cord-295807-68sukdb1	878	30	and	and	CC
cord-295807-68sukdb1	878	31	function	function	NN
cord-295807-68sukdb1	878	32	in	in	IN
cord-295807-68sukdb1	878	33	the	the	DT
cord-295807-68sukdb1	878	34	rat	rat	NN
cord-295807-68sukdb1	878	35	pH	ph	NN
cord-295807-68sukdb1	878	36	changes	change	NNS
cord-295807-68sukdb1	878	37	observed	observe	VBN
cord-295807-68sukdb1	878	38	in	in	IN
cord-295807-68sukdb1	878	39	the	the	DT
cord-295807-68sukdb1	878	40	inflamed	inflame	VBN
cord-295807-68sukdb1	878	41	gingival	gingival	NN
cord-295807-68sukdb1	878	42	crevice	crevice	NN
cord-295807-68sukdb1	878	43	modulate	modulate	VBP
cord-295807-68sukdb1	878	44	human	human	JJ
cord-295807-68sukdb1	878	45	polymorphonuclear	polymorphonuclear	JJ
cord-295807-68sukdb1	878	46	leukocyte	leukocyte	NN
cord-295807-68sukdb1	878	47	activation	activation	NN
cord-295807-68sukdb1	878	48	in	in	IN
cord-295807-68sukdb1	878	49	vitro	vitro	FW
cord-295807-68sukdb1	879	1	Acidosis	acidosis	NN
cord-295807-68sukdb1	879	2	differently	differently	RB
cord-295807-68sukdb1	879	3	modulates	modulate	VBZ
cord-295807-68sukdb1	879	4	the	the	DT
cord-295807-68sukdb1	879	5	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	879	6	program	program	NN
cord-295807-68sukdb1	879	7	in	in	IN
cord-295807-68sukdb1	879	8	monocytes	monocyte	NNS
cord-295807-68sukdb1	879	9	and	and	CC
cord-295807-68sukdb1	879	10	macrophages	macrophage	NNS
cord-295807-68sukdb1	880	1	The	the	DT
cord-295807-68sukdb1	880	2	effects	effect	NNS
cord-295807-68sukdb1	880	3	of	of	IN
cord-295807-68sukdb1	880	4	extracellular	extracellular	JJ
cord-295807-68sukdb1	880	5	pH	ph	NN
cord-295807-68sukdb1	880	6	on	on	IN
cord-295807-68sukdb1	880	7	immune	immune	JJ
cord-295807-68sukdb1	880	8	function	function	NN
cord-295807-68sukdb1	881	1	Anion	anion	NN
cord-295807-68sukdb1	881	2	exchanger	exchanger	NN
cord-295807-68sukdb1	881	3	2	2	CD
cord-295807-68sukdb1	881	4	is	be	VBZ
cord-295807-68sukdb1	881	5	critical	critical	JJ
cord-295807-68sukdb1	881	6	for	for	IN
cord-295807-68sukdb1	881	7	CD8(+	cd8(+	CD
cord-295807-68sukdb1	881	8	)	)	-RRB-
cord-295807-68sukdb1	882	1	T	T	NNP
cord-295807-68sukdb1	882	2	cells	cell	NNS
cord-295807-68sukdb1	882	3	to	to	TO
cord-295807-68sukdb1	882	4	maintain	maintain	VB
cord-295807-68sukdb1	882	5	pHi	phi	JJ
cord-295807-68sukdb1	882	6	homeostasis	homeostasis	NN
cord-295807-68sukdb1	882	7	and	and	CC
cord-295807-68sukdb1	882	8	modulate	modulate	VB
cord-295807-68sukdb1	882	9	immune	immune	JJ
cord-295807-68sukdb1	882	10	responses	response	NNS
cord-295807-68sukdb1	883	1	Systemic	systemic	JJ
cord-295807-68sukdb1	883	2	lupus	lupus	NN
cord-295807-68sukdb1	883	3	erythematosus	erythematosus	NN
cord-295807-68sukdb1	883	4	associated	associate	VBN
cord-295807-68sukdb1	883	5	with	with	IN
cord-295807-68sukdb1	883	6	type	type	NN
cord-295807-68sukdb1	883	7	4	4	CD
cord-295807-68sukdb1	883	8	renal	renal	JJ
cord-295807-68sukdb1	883	9	tubular	tubular	JJ
cord-295807-68sukdb1	883	10	acidosis	acidosis	NN
cord-295807-68sukdb1	883	11	:	:	:
cord-295807-68sukdb1	883	12	a	a	DT
cord-295807-68sukdb1	883	13	case	case	NN
cord-295807-68sukdb1	883	14	report	report	NN
cord-295807-68sukdb1	883	15	and	and	CC
cord-295807-68sukdb1	883	16	review	review	NN
cord-295807-68sukdb1	883	17	of	of	IN
cord-295807-68sukdb1	883	18	the	the	DT
cord-295807-68sukdb1	883	19	literature	literature	NN
cord-295807-68sukdb1	883	20	Systemic	systemic	JJ
cord-295807-68sukdb1	883	21	lupus	lupus	NN
cord-295807-68sukdb1	883	22	erythematosus	erythematosus	NN
cord-295807-68sukdb1	883	23	with	with	IN
cord-295807-68sukdb1	883	24	distal	distal	JJ
cord-295807-68sukdb1	883	25	renal	renal	JJ
cord-295807-68sukdb1	883	26	tubular	tubular	JJ
cord-295807-68sukdb1	883	27	acidosis	acidosis	NN
cord-295807-68sukdb1	883	28	presenting	present	VBG
cord-295807-68sukdb1	883	29	as	as	IN
cord-295807-68sukdb1	883	30	hypokalemic	hypokalemic	JJ
cord-295807-68sukdb1	883	31	paralysis	paralysis	NN
cord-295807-68sukdb1	883	32	with	with	IN
cord-295807-68sukdb1	883	33	respiratory	respiratory	JJ
cord-295807-68sukdb1	883	34	failure	failure	NN
cord-295807-68sukdb1	884	1	Oral	oral	JJ
cord-295807-68sukdb1	884	2	NaHCO3	nahco3	NN
cord-295807-68sukdb1	884	3	Activates	activate	VBZ
cord-295807-68sukdb1	884	4	a	a	DT
cord-295807-68sukdb1	884	5	Splenic	Splenic	NNP
cord-295807-68sukdb1	884	6	Anti	Anti	NNP
cord-295807-68sukdb1	884	7	-	-	NNP
cord-295807-68sukdb1	884	8	Inflammatory	Inflammatory	NNP
cord-295807-68sukdb1	884	9	Pathway	Pathway	NNP
cord-295807-68sukdb1	884	10	:	:	:
cord-295807-68sukdb1	885	1	Evidence	evidence	NN
cord-295807-68sukdb1	885	2	That	that	IN
cord-295807-68sukdb1	885	3	Cholinergic	Cholinergic	NNP
cord-295807-68sukdb1	885	4	Signals	signal	NNS
cord-295807-68sukdb1	885	5	Are	be	VBP
cord-295807-68sukdb1	885	6	Transmitted	transmit	VBN
cord-295807-68sukdb1	885	7	via	via	IN
cord-295807-68sukdb1	885	8	Mesothelial	Mesothelial	NNP
cord-295807-68sukdb1	885	9	Cells	Cells	NNP
cord-295807-68sukdb1	885	10	Sodium	Sodium	NNP
cord-295807-68sukdb1	885	11	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	886	1	Facilitates	facilitate	VBZ
cord-295807-68sukdb1	886	2	Low	low	JJ
cord-295807-68sukdb1	886	3	-	-	HYPH
cord-295807-68sukdb1	886	4	dose	dose	NN
cord-295807-68sukdb1	886	5	Oral	oral	JJ
cord-295807-68sukdb1	886	6	Tolerance	tolerance	NN
cord-295807-68sukdb1	886	7	To	to	IN
cord-295807-68sukdb1	886	8	Peanut	peanut	NN
cord-295807-68sukdb1	887	1	In	in	IN
cord-295807-68sukdb1	888	1	Mice	mice	NN
cord-295807-68sukdb1	888	2	Monocarboxylate	Monocarboxylate	NNP
cord-295807-68sukdb1	888	3	transporter	transporter	NN
cord-295807-68sukdb1	888	4	MCT1	MCT1	NNP
cord-295807-68sukdb1	888	5	is	be	VBZ
cord-295807-68sukdb1	888	6	a	a	DT
cord-295807-68sukdb1	888	7	target	target	NN
cord-295807-68sukdb1	888	8	for	for	IN
cord-295807-68sukdb1	888	9	immunosuppression	immunosuppression	NN
cord-295807-68sukdb1	888	10	Inhibition	inhibition	NN
cord-295807-68sukdb1	888	11	of	of	IN
cord-295807-68sukdb1	888	12	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	888	13	exchanger	exchanger	NN
cord-295807-68sukdb1	888	14	1	1	CD
cord-295807-68sukdb1	888	15	by	by	IN
cord-295807-68sukdb1	888	16	cariporide	cariporide	NN
cord-295807-68sukdb1	889	1	alleviates	alleviate	VBZ
cord-295807-68sukdb1	889	2	burn	burn	VB
cord-295807-68sukdb1	889	3	-	-	HYPH
cord-295807-68sukdb1	889	4	induced	induce	VBN
cord-295807-68sukdb1	889	5	multiple	multiple	JJ
cord-295807-68sukdb1	889	6	organ	organ	NN
cord-295807-68sukdb1	889	7	injury	injury	NN
cord-295807-68sukdb1	889	8	A.	a.	NN
cord-295807-68sukdb1	889	9	van	van	NNP
cord-295807-68sukdb1	889	10	den	den	NNP
cord-295807-68sukdb1	889	11	Hout	Hout	NNP
cord-295807-68sukdb1	889	12	,	,	,
cord-295807-68sukdb1	889	13	CO2	CO2	NNP
cord-295807-68sukdb1	889	14	vulnerability	vulnerability	NN
cord-295807-68sukdb1	889	15	in	in	IN
cord-295807-68sukdb1	889	16	panic	panic	NN
cord-295807-68sukdb1	889	17	disorder	disorder	NN
cord-295807-68sukdb1	889	18	Overshadowed	overshadow	VBN
cord-295807-68sukdb1	889	19	by	by	IN
cord-295807-68sukdb1	889	20	the	the	DT
cord-295807-68sukdb1	889	21	amygdala	amygdala	NN
cord-295807-68sukdb1	889	22	:	:	:
cord-295807-68sukdb1	890	1	the	the	DT
cord-295807-68sukdb1	890	2	bed	bed	NN
cord-295807-68sukdb1	890	3	nucleus	nucleus	NN
cord-295807-68sukdb1	890	4	of	of	IN
cord-295807-68sukdb1	890	5	the	the	DT
cord-295807-68sukdb1	890	6	stria	stria	NN
cord-295807-68sukdb1	890	7	terminalis	terminalis	NN
cord-295807-68sukdb1	890	8	emerges	emerge	VBZ
cord-295807-68sukdb1	890	9	as	as	IN
cord-295807-68sukdb1	890	10	key	key	JJ
cord-295807-68sukdb1	890	11	to	to	IN
cord-295807-68sukdb1	890	12	psychiatric	psychiatric	JJ
cord-295807-68sukdb1	890	13	disorders	disorder	NNS
cord-295807-68sukdb1	891	1	Acidsensing	Acidsensing	NNP
cord-295807-68sukdb1	891	2	ion	ion	NN
cord-295807-68sukdb1	891	3	channel	channel	NN
cord-295807-68sukdb1	891	4	1	1	CD
cord-295807-68sukdb1	891	5	is	be	VBZ
cord-295807-68sukdb1	891	6	localized	localize	VBN
cord-295807-68sukdb1	891	7	in	in	IN
cord-295807-68sukdb1	891	8	brain	brain	NN
cord-295807-68sukdb1	891	9	regions	region	NNS
cord-295807-68sukdb1	891	10	with	with	IN
cord-295807-68sukdb1	891	11	high	high	JJ
cord-295807-68sukdb1	891	12	synaptic	synaptic	JJ
cord-295807-68sukdb1	891	13	density	density	NN
cord-295807-68sukdb1	891	14	and	and	CC
cord-295807-68sukdb1	891	15	contributes	contribute	VBZ
cord-295807-68sukdb1	891	16	to	to	TO
cord-295807-68sukdb1	891	17	fear	fear	VB
cord-295807-68sukdb1	891	18	conditioning	conditioning	NN
cord-295807-68sukdb1	891	19	Overexpression	Overexpression	NNP
cord-295807-68sukdb1	891	20	of	of	IN
cord-295807-68sukdb1	891	21	acid	acid	NN
cord-295807-68sukdb1	891	22	-	-	HYPH
cord-295807-68sukdb1	891	23	sensing	sense	VBG
cord-295807-68sukdb1	891	24	ion	ion	NN
cord-295807-68sukdb1	891	25	channel	channel	NN
cord-295807-68sukdb1	891	26	1a	1a	NN
cord-295807-68sukdb1	891	27	in	in	IN
cord-295807-68sukdb1	891	28	transgenic	transgenic	JJ
cord-295807-68sukdb1	891	29	mice	mice	NN
cord-295807-68sukdb1	891	30	increases	increase	NNS
cord-295807-68sukdb1	891	31	acquired	acquire	VBN
cord-295807-68sukdb1	892	1	fear	fear	NN
cord-295807-68sukdb1	892	2	-	-	HYPH
cord-295807-68sukdb1	892	3	related	relate	VBN
cord-295807-68sukdb1	892	4	behavior	behavior	NN
cord-295807-68sukdb1	892	5	Decreased	decrease	VBD
cord-295807-68sukdb1	892	6	Brain	Brain	NNP
cord-295807-68sukdb1	892	7	pH	pH	NNP
cord-295807-68sukdb1	892	8	as	as	IN
cord-295807-68sukdb1	892	9	a	a	DT
cord-295807-68sukdb1	892	10	Shared	Shared	NNP
cord-295807-68sukdb1	892	11	Endophenotype	Endophenotype	NNP
cord-295807-68sukdb1	892	12	of	of	IN
cord-295807-68sukdb1	892	13	Psychiatric	Psychiatric	NNP
cord-295807-68sukdb1	892	14	Disorders	Disorders	NNPS
cord-295807-68sukdb1	892	15	Dietary	dietary	JJ
cord-295807-68sukdb1	892	16	Acid	Acid	NNP
cord-295807-68sukdb1	892	17	Load	Load	NNP
cord-295807-68sukdb1	892	18	and	and	CC
cord-295807-68sukdb1	892	19	Mental	Mental	NNP
cord-295807-68sukdb1	892	20	Health	Health	NNP
cord-295807-68sukdb1	892	21	Outcomes	Outcomes	NNPS
cord-295807-68sukdb1	892	22	in	in	IN
cord-295807-68sukdb1	892	23	Children	Children	NNPS
cord-295807-68sukdb1	892	24	and	and	CC
cord-295807-68sukdb1	892	25	Adolescents	Adolescents	NNPS
cord-295807-68sukdb1	892	26	:	:	:
cord-295807-68sukdb1	893	1	Results	result	NNS
cord-295807-68sukdb1	893	2	from	from	IN
cord-295807-68sukdb1	893	3	the	the	DT
cord-295807-68sukdb1	893	4	GINIplus	giniplus	NN
cord-295807-68sukdb1	893	5	and	and	CC
cord-295807-68sukdb1	894	1	LISA	LISA	NNP
cord-295807-68sukdb1	894	2	Birth	Birth	NNP
cord-295807-68sukdb1	894	3	Cohort	Cohort	NNP
cord-295807-68sukdb1	894	4	Studies	Studies	NNPS
cord-295807-68sukdb1	894	5	Understanding	Understanding	NNP
cord-295807-68sukdb1	894	6	and	and	CC
cord-295807-68sukdb1	894	7	predicting	predict	VBG
cord-295807-68sukdb1	894	8	suicidality	suicidality	NN
cord-295807-68sukdb1	894	9	using	use	VBG
cord-295807-68sukdb1	894	10	a	a	DT
cord-295807-68sukdb1	894	11	combined	combine	VBN
cord-295807-68sukdb1	894	12	genomic	genomic	JJ
cord-295807-68sukdb1	894	13	and	and	CC
cord-295807-68sukdb1	894	14	clinical	clinical	JJ
cord-295807-68sukdb1	894	15	risk	risk	NN
cord-295807-68sukdb1	894	16	assessment	assessment	NN
cord-295807-68sukdb1	894	17	approach	approach	NN
cord-295807-68sukdb1	894	18	Metabolic	metabolic	JJ
cord-295807-68sukdb1	894	19	Acidosis	acidosis	NN
cord-295807-68sukdb1	894	20	of	of	IN
cord-295807-68sukdb1	894	21	CKD	CKD	NNP
cord-295807-68sukdb1	894	22	:	:	:
cord-295807-68sukdb1	895	1	An	an	DT
cord-295807-68sukdb1	895	2	Update	update	NN
cord-295807-68sukdb1	895	3	Prevalence	prevalence	NN
cord-295807-68sukdb1	895	4	of	of	IN
cord-295807-68sukdb1	895	5	depression	depression	NN
cord-295807-68sukdb1	895	6	and	and	CC
cord-295807-68sukdb1	895	7	suicidal	suicidal	JJ
cord-295807-68sukdb1	895	8	ideation	ideation	NN
cord-295807-68sukdb1	895	9	increases	increase	VBZ
cord-295807-68sukdb1	895	10	proportionally	proportionally	RB
cord-295807-68sukdb1	895	11	with	with	IN
cord-295807-68sukdb1	895	12	renal	renal	JJ
cord-295807-68sukdb1	895	13	function	function	NN
cord-295807-68sukdb1	895	14	decline	decline	NN
cord-295807-68sukdb1	895	15	,	,	,
cord-295807-68sukdb1	895	16	beginning	begin	VBG
cord-295807-68sukdb1	895	17	from	from	IN
cord-295807-68sukdb1	895	18	early	early	JJ
cord-295807-68sukdb1	895	19	stages	stage	NNS
cord-295807-68sukdb1	895	20	of	of	IN
cord-295807-68sukdb1	895	21	chronic	chronic	JJ
cord-295807-68sukdb1	895	22	kidney	kidney	NN
cord-295807-68sukdb1	895	23	disease	disease	NN
cord-295807-68sukdb1	895	24	Carbon	carbon	NN
cord-295807-68sukdb1	895	25	dioxide	dioxide	NN
cord-295807-68sukdb1	895	26	test	test	NN
cord-295807-68sukdb1	895	27	as	as	IN
cord-295807-68sukdb1	895	28	an	an	DT
cord-295807-68sukdb1	895	29	additional	additional	JJ
cord-295807-68sukdb1	895	30	clinical	clinical	JJ
cord-295807-68sukdb1	895	31	measure	measure	NN
cord-295807-68sukdb1	895	32	of	of	IN
cord-295807-68sukdb1	895	33	treatment	treatment	NN
cord-295807-68sukdb1	895	34	response	response	NN
cord-295807-68sukdb1	895	35	in	in	IN
cord-295807-68sukdb1	895	36	panic	panic	NN
cord-295807-68sukdb1	895	37	disorder	disorder	NN
cord-295807-68sukdb1	895	38	Responses	response	NNS
cord-295807-68sukdb1	895	39	to	to	IN
cord-295807-68sukdb1	895	40	hypercarbia	hypercarbia	NN
cord-295807-68sukdb1	895	41	induced	induce	VBN
cord-295807-68sukdb1	895	42	by	by	IN
cord-295807-68sukdb1	895	43	acetazolamide	acetazolamide	NN
cord-295807-68sukdb1	895	44	in	in	IN
cord-295807-68sukdb1	895	45	panic	panic	NN
cord-295807-68sukdb1	895	46	disorder	disorder	NN
cord-295807-68sukdb1	895	47	patients	patient	NNS
cord-295807-68sukdb1	895	48	Increased	increase	VBN
cord-295807-68sukdb1	895	49	lactate	lactate	NN
cord-295807-68sukdb1	895	50	levels	level	NNS
cord-295807-68sukdb1	895	51	and	and	CC
cord-295807-68sukdb1	895	52	reduced	reduce	VBN
cord-295807-68sukdb1	895	53	pH	ph	NN
cord-295807-68sukdb1	895	54	in	in	IN
cord-295807-68sukdb1	895	55	postmortem	postmortem	JJ
cord-295807-68sukdb1	895	56	brains	brain	NNS
cord-295807-68sukdb1	895	57	of	of	IN
cord-295807-68sukdb1	895	58	schizophrenics	schizophrenic	NNS
cord-295807-68sukdb1	895	59	:	:	:
cord-295807-68sukdb1	895	60	medication	medication	NN
cord-295807-68sukdb1	895	61	confounds	confound	VBZ
cord-295807-68sukdb1	895	62	Possible	possible	JJ
cord-295807-68sukdb1	895	63	alternatives	alternative	NNS
cord-295807-68sukdb1	895	64	to	to	TO
cord-295807-68sukdb1	895	65	soda	soda	VB
cord-295807-68sukdb1	895	66	lime	lime	NN
cord-295807-68sukdb1	895	67	Absorption	absorption	NN
cord-295807-68sukdb1	895	68	of	of	IN
cord-295807-68sukdb1	895	69	carbon	carbon	NN
cord-295807-68sukdb1	895	70	dioxide	dioxide	NN
cord-295807-68sukdb1	895	71	Interaction	Interaction	NNP
cord-295807-68sukdb1	895	72	of	of	IN
cord-295807-68sukdb1	895	73	inhalational	inhalational	JJ
cord-295807-68sukdb1	895	74	anaesthetics	anaesthetic	NNS
cord-295807-68sukdb1	895	75	with	with	IN
cord-295807-68sukdb1	895	76	CO2	CO2	NNP
cord-295807-68sukdb1	895	77	absorbents	absorbent	NNS
cord-295807-68sukdb1	895	78	Hypercapnia	Hypercapnia	NNP
cord-295807-68sukdb1	895	79	and	and	CC
cord-295807-68sukdb1	895	80	acidosis	acidosis	NN
cord-295807-68sukdb1	895	81	in	in	IN
cord-295807-68sukdb1	895	82	sepsis	sepsis	NN
cord-295807-68sukdb1	895	83	:	:	:
cord-295807-68sukdb1	895	84	a	a	DT
cord-295807-68sukdb1	895	85	double	double	RB
cord-295807-68sukdb1	895	86	-	-	HYPH
cord-295807-68sukdb1	895	87	edged	edged	JJ
cord-295807-68sukdb1	895	88	sword	sword	NN
cord-295807-68sukdb1	895	89	?	?	.
cord-295807-68sukdb1	896	1	Propofol	Propofol	NNP
cord-295807-68sukdb1	896	2	Infusion	infusion	NN
cord-295807-68sukdb1	896	3	Associated	Associated	NNP
cord-295807-68sukdb1	896	4	Metabolic	metabolic	JJ
cord-295807-68sukdb1	896	5	Acidosis	acidosis	NN
cord-295807-68sukdb1	896	6	in	in	IN
cord-295807-68sukdb1	896	7	Patients	patient	NNS
cord-295807-68sukdb1	897	1	Undergoing	undergo	VBG
cord-295807-68sukdb1	897	2	Neurosurgical	Neurosurgical	NNP
cord-295807-68sukdb1	897	3	Anesthesia	Anesthesia	NNP
cord-295807-68sukdb1	897	4	:	:	:
cord-295807-68sukdb1	898	1	A	a	DT
cord-295807-68sukdb1	898	2	Retrospective	Retrospective	NNP
cord-295807-68sukdb1	898	3	Study	Study	NNP
cord-295807-68sukdb1	898	4	Perioperative	Perioperative	NNP
cord-295807-68sukdb1	898	5	metabolic	metabolic	JJ
cord-295807-68sukdb1	898	6	acidosis	acidosis	NN
cord-295807-68sukdb1	898	7	:	:	:
cord-295807-68sukdb1	899	1	The	the	DT
cord-295807-68sukdb1	899	2	Bradford	Bradford	NNP
cord-295807-68sukdb1	899	3	Anaesthetic	Anaesthetic	NNP
cord-295807-68sukdb1	899	4	Department	Department	NNP
cord-295807-68sukdb1	899	5	Acidosis	Acidosis	NNP
cord-295807-68sukdb1	899	6	Study	Study	NNP
cord-295807-68sukdb1	899	7	Chasing	chase	VBG
cord-295807-68sukdb1	899	8	the	the	DT
cord-295807-68sukdb1	899	9	base	base	NN
cord-295807-68sukdb1	899	10	deficit	deficit	NN
cord-295807-68sukdb1	899	11	:	:	:
cord-295807-68sukdb1	899	12	hyperchloraemic	hyperchloraemic	NNP
cord-295807-68sukdb1	899	13	acidosis	acidosis	NN
cord-295807-68sukdb1	899	14	following	follow	VBG
cord-295807-68sukdb1	899	15	0.9	0.9	CD
cord-295807-68sukdb1	899	16	%	%	NN
cord-295807-68sukdb1	899	17	saline	saline	NN
cord-295807-68sukdb1	899	18	fluid	fluid	NN
cord-295807-68sukdb1	899	19	resuscitation	resuscitation	NN
cord-295807-68sukdb1	899	20	Factors	factor	NNS
cord-295807-68sukdb1	899	21	related	relate	VBN
cord-295807-68sukdb1	899	22	to	to	IN
cord-295807-68sukdb1	899	23	postoperative	postoperative	JJ
cord-295807-68sukdb1	899	24	metabolic	metabolic	JJ
cord-295807-68sukdb1	899	25	acidosis	acidosis	NN
cord-295807-68sukdb1	899	26	following	follow	VBG
cord-295807-68sukdb1	899	27	major	major	JJ
cord-295807-68sukdb1	899	28	abdominal	abdominal	JJ
cord-295807-68sukdb1	899	29	surgery	surgery	NN
cord-295807-68sukdb1	899	30	Cause	cause	NN
cord-295807-68sukdb1	899	31	of	of	IN
cord-295807-68sukdb1	899	32	metabolic	metabolic	JJ
cord-295807-68sukdb1	899	33	acidosis	acidosis	NN
cord-295807-68sukdb1	899	34	in	in	IN
cord-295807-68sukdb1	899	35	prolonged	prolong	VBN
cord-295807-68sukdb1	899	36	surgery	surgery	NN
cord-295807-68sukdb1	900	1	Postoperative	postoperative	JJ
cord-295807-68sukdb1	900	2	metabolic	metabolic	JJ
cord-295807-68sukdb1	900	3	alkalosis	alkalosis	NN
cord-295807-68sukdb1	900	4	following	follow	VBG
cord-295807-68sukdb1	900	5	general	general	JJ
cord-295807-68sukdb1	900	6	surgery	surgery	NN
cord-295807-68sukdb1	900	7	:	:	:
cord-295807-68sukdb1	901	1	its	-PRON-	PRP$
cord-295807-68sukdb1	901	2	incidence	incidence	NN
cord-295807-68sukdb1	901	3	and	and	CC
cord-295807-68sukdb1	901	4	possible	possible	JJ
cord-295807-68sukdb1	901	5	etiology	etiology	NN
cord-295807-68sukdb1	901	6	Citrate	Citrate	NNP
cord-295807-68sukdb1	901	7	metabolism	metabolism	NN
cord-295807-68sukdb1	901	8	and	and	CC
cord-295807-68sukdb1	901	9	its	-PRON-	PRP$
cord-295807-68sukdb1	901	10	complications	complication	NNS
cord-295807-68sukdb1	901	11	in	in	IN
cord-295807-68sukdb1	901	12	non	non	JJ
cord-295807-68sukdb1	901	13	-	-	JJ
cord-295807-68sukdb1	901	14	massive	massive	JJ
cord-295807-68sukdb1	901	15	blood	blood	NN
cord-295807-68sukdb1	901	16	transfusions	transfusion	NNS
cord-295807-68sukdb1	901	17	:	:	:
cord-295807-68sukdb1	901	18	association	association	NN
cord-295807-68sukdb1	901	19	with	with	IN
cord-295807-68sukdb1	901	20	decompensated	decompensate	VBN
cord-295807-68sukdb1	901	21	metabolic	metabolic	JJ
cord-295807-68sukdb1	901	22	alkalosis+respiratory	alkalosis+respiratory	NNP
cord-295807-68sukdb1	901	23	acidosis	acidosis	NN
cord-295807-68sukdb1	901	24	and	and	CC
cord-295807-68sukdb1	901	25	serum	serum	NN
cord-295807-68sukdb1	901	26	electrolyte	electrolyte	NN
cord-295807-68sukdb1	901	27	levels	level	NNS
cord-295807-68sukdb1	902	1	Outcome	outcome	NN
cord-295807-68sukdb1	902	2	of	of	IN
cord-295807-68sukdb1	902	3	surgical	surgical	JJ
cord-295807-68sukdb1	902	4	patients	patient	NNS
cord-295807-68sukdb1	902	5	who	who	WP
cord-295807-68sukdb1	902	6	present	present	VBP
cord-295807-68sukdb1	902	7	acidosis	acidosis	NN
cord-295807-68sukdb1	902	8	postoperatively	postoperatively	RB
cord-295807-68sukdb1	902	9	Biochemical	biochemical	JJ
cord-295807-68sukdb1	902	10	changes	change	NNS
cord-295807-68sukdb1	902	11	in	in	IN
cord-295807-68sukdb1	902	12	stored	store	VBN
cord-295807-68sukdb1	902	13	donor	donor	NN
cord-295807-68sukdb1	902	14	units	unit	NNS
cord-295807-68sukdb1	902	15	:	:	:
cord-295807-68sukdb1	902	16	implications	implication	NNS
cord-295807-68sukdb1	902	17	on	on	IN
cord-295807-68sukdb1	902	18	the	the	DT
cord-295807-68sukdb1	902	19	efficacy	efficacy	NN
cord-295807-68sukdb1	902	20	of	of	IN
cord-295807-68sukdb1	902	21	blood	blood	NN
cord-295807-68sukdb1	902	22	transfusion	transfusion	NN
cord-295807-68sukdb1	902	23	Clinical	clinical	JJ
cord-295807-68sukdb1	902	24	impact	impact	NN
cord-295807-68sukdb1	902	25	of	of	IN
cord-295807-68sukdb1	902	26	blood	blood	NN
cord-295807-68sukdb1	902	27	storage	storage	NN
cord-295807-68sukdb1	902	28	lesions	lesion	NNS
cord-295807-68sukdb1	902	29	Influence	influence	NN
cord-295807-68sukdb1	902	30	of	of	IN
cord-295807-68sukdb1	902	31	pH	pH	NNP
cord-295807-68sukdb1	902	32	on	on	IN
cord-295807-68sukdb1	902	33	wound	wound	NN
cord-295807-68sukdb1	902	34	-	-	HYPH
cord-295807-68sukdb1	902	35	healing	healing	NN
cord-295807-68sukdb1	902	36	:	:	:
cord-295807-68sukdb1	902	37	a	a	DT
cord-295807-68sukdb1	902	38	new	new	JJ
cord-295807-68sukdb1	902	39	perspective	perspective	NN
cord-295807-68sukdb1	902	40	for	for	IN
cord-295807-68sukdb1	902	41	wound	wound	NN
cord-295807-68sukdb1	902	42	-	-	HYPH
cord-295807-68sukdb1	902	43	therapy	therapy	NN
cord-295807-68sukdb1	902	44	?	?	.
cord-295807-68sukdb1	903	1	Dichloroacetate	dichloroacetate	NN
cord-295807-68sukdb1	903	2	stabilizes	stabilize	VBZ
cord-295807-68sukdb1	903	3	the	the	DT
cord-295807-68sukdb1	903	4	intraoperative	intraoperative	JJ
cord-295807-68sukdb1	903	5	acid	acid	NN
cord-295807-68sukdb1	903	6	-	-	HYPH
cord-295807-68sukdb1	903	7	base	base	NN
cord-295807-68sukdb1	903	8	balance	balance	NN
cord-295807-68sukdb1	903	9	during	during	IN
cord-295807-68sukdb1	903	10	liver	liver	NN
cord-295807-68sukdb1	903	11	transplantation	transplantation	NN
cord-295807-68sukdb1	903	12	pH	pH	NNP
cord-295807-68sukdb1	903	13	modulation	modulation	NN
cord-295807-68sukdb1	903	14	ameliorates	ameliorate	VBZ
cord-295807-68sukdb1	903	15	the	the	DT
cord-295807-68sukdb1	903	16	red	red	JJ
cord-295807-68sukdb1	903	17	blood	blood	NN
cord-295807-68sukdb1	903	18	cell	cell	NN
cord-295807-68sukdb1	903	19	storage	storage	NN
cord-295807-68sukdb1	903	20	lesion	lesion	NN
cord-295807-68sukdb1	903	21	in	in	IN
cord-295807-68sukdb1	903	22	a	a	DT
cord-295807-68sukdb1	903	23	murine	murine	JJ
cord-295807-68sukdb1	903	24	model	model	NN
cord-295807-68sukdb1	903	25	of	of	IN
cord-295807-68sukdb1	903	26	transfusion	transfusion	NN
cord-295807-68sukdb1	903	27	An	an	DT
cord-295807-68sukdb1	903	28	analysis	analysis	NN
cord-295807-68sukdb1	903	29	of	of	IN
cord-295807-68sukdb1	903	30	the	the	DT
cord-295807-68sukdb1	903	31	buffer	buffer	NN
cord-295807-68sukdb1	903	32	systems	system	NNS
cord-295807-68sukdb1	903	33	in	in	IN
cord-295807-68sukdb1	903	34	saliva	saliva	NN
cord-295807-68sukdb1	903	35	Change	change	NN
cord-295807-68sukdb1	903	36	of	of	IN
cord-295807-68sukdb1	903	37	saliva	saliva	NN
cord-295807-68sukdb1	903	38	composition	composition	NN
cord-295807-68sukdb1	903	39	with	with	IN
cord-295807-68sukdb1	903	40	radiotherapy	radiotherapy	NN
cord-295807-68sukdb1	903	41	Effect	effect	NN
cord-295807-68sukdb1	903	42	of	of	IN
cord-295807-68sukdb1	903	43	decreased	decrease	VBD
cord-295807-68sukdb1	903	44	salivation	salivation	NN
cord-295807-68sukdb1	903	45	and	and	CC
cord-295807-68sukdb1	903	46	pH	ph	NN
cord-295807-68sukdb1	903	47	on	on	IN
cord-295807-68sukdb1	903	48	the	the	DT
cord-295807-68sukdb1	903	49	adherence	adherence	NN
cord-295807-68sukdb1	903	50	of	of	IN
cord-295807-68sukdb1	903	51	Klebsiella	Klebsiella	NNP
cord-295807-68sukdb1	903	52	species	specie	NNS
cord-295807-68sukdb1	903	53	to	to	IN
cord-295807-68sukdb1	903	54	human	human	JJ
cord-295807-68sukdb1	903	55	buccal	buccal	JJ
cord-295807-68sukdb1	903	56	epithelial	epithelial	JJ
cord-295807-68sukdb1	903	57	cells	cell	NNS
cord-295807-68sukdb1	903	58	Evaluation	Evaluation	NNP
cord-295807-68sukdb1	903	59	of	of	IN
cord-295807-68sukdb1	903	60	non	non	JJ
cord-295807-68sukdb1	903	61	-	-	JJ
cord-295807-68sukdb1	903	62	microbial	microbial	JJ
cord-295807-68sukdb1	903	63	salivary	salivary	NN
cord-295807-68sukdb1	903	64	caries	caries	NN
cord-295807-68sukdb1	903	65	activity	activity	NN
cord-295807-68sukdb1	903	66	parameters	parameter	NNS
cord-295807-68sukdb1	903	67	and	and	CC
cord-295807-68sukdb1	903	68	salivary	salivary	JJ
cord-295807-68sukdb1	903	69	biochemical	biochemical	JJ
cord-295807-68sukdb1	903	70	indicators	indicator	NNS
cord-295807-68sukdb1	903	71	in	in	IN
cord-295807-68sukdb1	903	72	predicting	predict	VBG
cord-295807-68sukdb1	903	73	dental	dental	JJ
cord-295807-68sukdb1	903	74	caries	caries	NN
cord-295807-68sukdb1	903	75	Salivary	salivary	JJ
cord-295807-68sukdb1	903	76	parameters	parameter	NNS
cord-295807-68sukdb1	903	77	and	and	CC
cord-295807-68sukdb1	903	78	oral	oral	JJ
cord-295807-68sukdb1	903	79	health	health	NN
cord-295807-68sukdb1	903	80	status	status	NN
cord-295807-68sukdb1	903	81	amongst	amongst	IN
cord-295807-68sukdb1	903	82	adolescents	adolescent	NNS
cord-295807-68sukdb1	903	83	in	in	IN
cord-295807-68sukdb1	903	84	Mexico	Mexico	NNP
cord-295807-68sukdb1	903	85	Salivary	Salivary	NNP
cord-295807-68sukdb1	903	86	Flow	Flow	NNP
cord-295807-68sukdb1	903	87	Rate	rate	NN
cord-295807-68sukdb1	903	88	,	,	,
cord-295807-68sukdb1	903	89	pH	ph	NN
cord-295807-68sukdb1	903	90	,	,	,
cord-295807-68sukdb1	903	91	Buffering	Buffering	NNP
cord-295807-68sukdb1	903	92	Capacity	Capacity	NNP
cord-295807-68sukdb1	903	93	,	,	,
cord-295807-68sukdb1	903	94	Total	Total	NNP
cord-295807-68sukdb1	903	95	Protein	Protein	NNP
cord-295807-68sukdb1	903	96	,	,	,
cord-295807-68sukdb1	903	97	Oxidative	Oxidative	NNP
cord-295807-68sukdb1	903	98	Stress	Stress	NNP
cord-295807-68sukdb1	903	99	and	and	CC
cord-295807-68sukdb1	903	100	Antioxidant	Antioxidant	NNP
cord-295807-68sukdb1	903	101	Capacity	Capacity	NNP
cord-295807-68sukdb1	903	102	in	in	IN
cord-295807-68sukdb1	903	103	Children	Children	NNP
cord-295807-68sukdb1	903	104	with	with	IN
cord-295807-68sukdb1	903	105	and	and	CC
cord-295807-68sukdb1	903	106	without	without	IN
cord-295807-68sukdb1	903	107	Dental	Dental	NNP
cord-295807-68sukdb1	903	108	Caries	carie	VBZ
cord-295807-68sukdb1	903	109	Salivary	Salivary	NNP
cord-295807-68sukdb1	903	110	buffer	buffer	NN
cord-295807-68sukdb1	903	111	capacity	capacity	NN
cord-295807-68sukdb1	903	112	,	,	,
cord-295807-68sukdb1	903	113	pH	pH	NNP
cord-295807-68sukdb1	903	114	,	,	,
cord-295807-68sukdb1	903	115	and	and	CC
cord-295807-68sukdb1	903	116	stimulated	stimulate	VBD
cord-295807-68sukdb1	903	117	flow	flow	NN
cord-295807-68sukdb1	903	118	rate	rate	NN
cord-295807-68sukdb1	903	119	of	of	IN
cord-295807-68sukdb1	903	120	crack	crack	NN
cord-295807-68sukdb1	903	121	cocaine	cocaine	NN
cord-295807-68sukdb1	903	122	users	user	NNS
cord-295807-68sukdb1	903	123	Effect	Effect	NNP
cord-295807-68sukdb1	903	124	of	of	IN
cord-295807-68sukdb1	903	125	Sodium	Sodium	NNP
cord-295807-68sukdb1	903	126	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	903	127	Mouth	Mouth	NNP
cord-295807-68sukdb1	903	128	Wash	wash	VBP
cord-295807-68sukdb1	903	129	on	on	IN
cord-295807-68sukdb1	903	130	Salivary	Salivary	NNP
cord-295807-68sukdb1	903	131	pH	pH	NNP
cord-295807-68sukdb1	903	132	and	and	CC
cord-295807-68sukdb1	903	133	Interleukin-1β	Interleukin-1β	NNP
cord-295807-68sukdb1	903	134	Levels	Levels	NNPS
cord-295807-68sukdb1	903	135	among	among	IN
cord-295807-68sukdb1	903	136	Smokers	smoker	NNS
cord-295807-68sukdb1	903	137	Salivary	Salivary	NNP
cord-295807-68sukdb1	903	138	Biomarkers	Biomarkers	NNPS
cord-295807-68sukdb1	903	139	and	and	CC
cord-295807-68sukdb1	903	140	Oral	Oral	NNP
cord-295807-68sukdb1	903	141	Microbial	Microbial	NNP
cord-295807-68sukdb1	903	142	Load	Load	NNP
cord-295807-68sukdb1	903	143	in	in	IN
cord-295807-68sukdb1	903	144	Relation	Relation	NNP
cord-295807-68sukdb1	903	145	to	to	IN
cord-295807-68sukdb1	903	146	the	the	DT
cord-295807-68sukdb1	903	147	Dental	Dental	NNP
cord-295807-68sukdb1	903	148	Status	Status	NNP
cord-295807-68sukdb1	903	149	of	of	IN
cord-295807-68sukdb1	903	150	Adults	Adults	NNPS
cord-295807-68sukdb1	903	151	with	with	IN
cord-295807-68sukdb1	903	152	Cystic	Cystic	NNP
cord-295807-68sukdb1	903	153	Fibrosis	Fibrosis	NNP
cord-295807-68sukdb1	903	154	Salivary	Salivary	NNP
cord-295807-68sukdb1	903	155	changes	change	NNS
cord-295807-68sukdb1	903	156	and	and	CC
cord-295807-68sukdb1	903	157	dental	dental	JJ
cord-295807-68sukdb1	903	158	caries	caries	NN
cord-295807-68sukdb1	903	159	as	as	IN
cord-295807-68sukdb1	903	160	potential	potential	JJ
cord-295807-68sukdb1	903	161	oral	oral	JJ
cord-295807-68sukdb1	903	162	markers	marker	NNS
cord-295807-68sukdb1	903	163	of	of	IN
cord-295807-68sukdb1	903	164	autoimmune	autoimmune	JJ
cord-295807-68sukdb1	903	165	salivary	salivary	NN
cord-295807-68sukdb1	903	166	gland	gland	NN
cord-295807-68sukdb1	903	167	dysfunction	dysfunction	NN
cord-295807-68sukdb1	903	168	in	in	IN
cord-295807-68sukdb1	903	169	primary	primary	JJ
cord-295807-68sukdb1	903	170	Sjögren	Sjögren	NNP
cord-295807-68sukdb1	903	171	's	's	POS
cord-295807-68sukdb1	903	172	syndrome	syndrome	NN
cord-295807-68sukdb1	903	173	Unstimulated	unstimulated	JJ
cord-295807-68sukdb1	903	174	salivary	salivary	NN
cord-295807-68sukdb1	903	175	flow	flow	NN
cord-295807-68sukdb1	903	176	,	,	,
cord-295807-68sukdb1	903	177	pH	pH	NNP
cord-295807-68sukdb1	903	178	,	,	,
cord-295807-68sukdb1	903	179	proteins	protein	NNS
cord-295807-68sukdb1	903	180	and	and	CC
cord-295807-68sukdb1	903	181	oral	oral	JJ
cord-295807-68sukdb1	903	182	health	health	NN
cord-295807-68sukdb1	903	183	in	in	IN
cord-295807-68sukdb1	903	184	patients	patient	NNS
cord-295807-68sukdb1	903	185	with	with	IN
cord-295807-68sukdb1	903	186	Juvenile	Juvenile	NNP
cord-295807-68sukdb1	903	187	Idiopathic	Idiopathic	NNP
cord-295807-68sukdb1	903	188	Arthritis	arthritis	NN
cord-295807-68sukdb1	903	189	New	new	JJ
cord-295807-68sukdb1	903	190	paradigms	paradigm	NNS
cord-295807-68sukdb1	903	191	on	on	IN
cord-295807-68sukdb1	903	192	the	the	DT
cord-295807-68sukdb1	903	193	transport	transport	NN
cord-295807-68sukdb1	903	194	functions	function	NNS
cord-295807-68sukdb1	903	195	of	of	IN
cord-295807-68sukdb1	903	196	maturation	maturation	NN
cord-295807-68sukdb1	903	197	-	-	HYPH
cord-295807-68sukdb1	903	198	stage	stage	NN
cord-295807-68sukdb1	903	199	ameloblasts	ameloblast	VBZ
cord-295807-68sukdb1	903	200	A	a	DT
cord-295807-68sukdb1	903	201	novel	novel	NN
cord-295807-68sukdb1	903	202	mutant	mutant	NN
cord-295807-68sukdb1	904	1	Na	Na	NNP
cord-295807-68sukdb1	905	1	+	+	CC
cord-295807-68sukdb1	905	2	/HCO3	/HCO3	.
cord-295807-68sukdb1	906	1	-cotransporter	-cotransporter	:
cord-295807-68sukdb1	907	1	NBCe1	NBCe1	NNP
cord-295807-68sukdb1	907	2	in	in	IN
cord-295807-68sukdb1	907	3	a	a	DT
cord-295807-68sukdb1	907	4	case	case	NN
cord-295807-68sukdb1	907	5	of	of	IN
cord-295807-68sukdb1	907	6	compound	compound	NN
cord-295807-68sukdb1	907	7	-	-	HYPH
cord-295807-68sukdb1	907	8	heterozygous	heterozygous	JJ
cord-295807-68sukdb1	907	9	inheritance	inheritance	NN
cord-295807-68sukdb1	907	10	of	of	IN
cord-295807-68sukdb1	907	11	proximal	proximal	JJ
cord-295807-68sukdb1	907	12	renal	renal	JJ
cord-295807-68sukdb1	907	13	tubular	tubular	JJ
cord-295807-68sukdb1	907	14	acidosis	acidosis	NN
cord-295807-68sukdb1	907	15	Extrarenal	Extrarenal	NNP
cord-295807-68sukdb1	907	16	Signs	Signs	NNPS
cord-295807-68sukdb1	907	17	of	of	IN
cord-295807-68sukdb1	907	18	Proximal	Proximal	NNP
cord-295807-68sukdb1	907	19	Renal	Renal	NNP
cord-295807-68sukdb1	907	20	Tubular	Tubular	NNP
cord-295807-68sukdb1	907	21	Acidosis	acidosis	NN
cord-295807-68sukdb1	907	22	Persist	persist	VBP
cord-295807-68sukdb1	907	23	in	in	IN
cord-295807-68sukdb1	908	1	Nonacidemic	Nonacidemic	NNP
cord-295807-68sukdb1	908	2	Nbce1b	Nbce1b	NNP
cord-295807-68sukdb1	908	3	/	/	SYM
cord-295807-68sukdb1	908	4	c	c	NN
cord-295807-68sukdb1	908	5	-	-	:
cord-295807-68sukdb1	908	6	Null	null	JJ
cord-295807-68sukdb1	908	7	Mice	mouse	NNS
cord-295807-68sukdb1	908	8	Salivary	Salivary	NNP
cord-295807-68sukdb1	908	9	pH	ph	NN
cord-295807-68sukdb1	908	10	:	:	:
cord-295807-68sukdb1	909	1	A	a	DT
cord-295807-68sukdb1	909	2	diagnostic	diagnostic	JJ
cord-295807-68sukdb1	909	3	biomarker	biomarker	NN
cord-295807-68sukdb1	909	4	Baking	baking	NN
cord-295807-68sukdb1	909	5	soda	soda	NN
cord-295807-68sukdb1	909	6	dentifrices	dentifrice	NNS
cord-295807-68sukdb1	909	7	and	and	CC
cord-295807-68sukdb1	909	8	oral	oral	JJ
cord-295807-68sukdb1	909	9	health	health	NN
cord-295807-68sukdb1	910	1	The	the	DT
cord-295807-68sukdb1	910	2	effect	effect	NN
cord-295807-68sukdb1	910	3	of	of	IN
cord-295807-68sukdb1	910	4	sodium	sodium	NN
cord-295807-68sukdb1	910	5	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	910	6	oral	oral	JJ
cord-295807-68sukdb1	910	7	rinse	rinse	NN
cord-295807-68sukdb1	910	8	on	on	IN
cord-295807-68sukdb1	910	9	salivary	salivary	NN
cord-295807-68sukdb1	910	10	pH	ph	NN
cord-295807-68sukdb1	910	11	and	and	CC
cord-295807-68sukdb1	910	12	oral	oral	JJ
cord-295807-68sukdb1	910	13	microflora	microflora	NN
cord-295807-68sukdb1	910	14	:	:	:
cord-295807-68sukdb1	911	1	A	a	DT
cord-295807-68sukdb1	911	2	prospective	prospective	JJ
cord-295807-68sukdb1	911	3	cohort	cohort	NN
cord-295807-68sukdb1	911	4	study	study	NN
cord-295807-68sukdb1	912	1	Salivary	salivary	NN
cord-295807-68sukdb1	912	2	pH	ph	NN
cord-295807-68sukdb1	912	3	after	after	IN
cord-295807-68sukdb1	912	4	a	a	DT
cord-295807-68sukdb1	912	5	glucose	glucose	NN
cord-295807-68sukdb1	912	6	rinse	rinse	NN
cord-295807-68sukdb1	912	7	:	:	:
cord-295807-68sukdb1	912	8	effect	effect	NN
cord-295807-68sukdb1	912	9	of	of	IN
cord-295807-68sukdb1	912	10	a	a	DT
cord-295807-68sukdb1	912	11	new	new	JJ
cord-295807-68sukdb1	912	12	mucoadhesive	mucoadhesive	NN
cord-295807-68sukdb1	912	13	spray	spray	NN
cord-295807-68sukdb1	912	14	(	(	-LRB-
cord-295807-68sukdb1	912	15	Cariex	Cariex	NNP
cord-295807-68sukdb1	912	16	)	)	-RRB-
cord-295807-68sukdb1	912	17	based	base	VBN
cord-295807-68sukdb1	912	18	on	on	IN
cord-295807-68sukdb1	912	19	sodium	sodium	NN
cord-295807-68sukdb1	912	20	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	912	21	and	and	CC
cord-295807-68sukdb1	912	22	xylitol	xylitol	NN
cord-295807-68sukdb1	912	23	Effect	effect	NN
cord-295807-68sukdb1	912	24	of	of	IN
cord-295807-68sukdb1	912	25	Chewing	chew	VBG
cord-295807-68sukdb1	912	26	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	912	27	-	-	HYPH
cord-295807-68sukdb1	912	28	containing	contain	VBG
cord-295807-68sukdb1	912	29	Sugar	sugar	NN
cord-295807-68sukdb1	912	30	-	-	HYPH
cord-295807-68sukdb1	912	31	free	free	JJ
cord-295807-68sukdb1	912	32	Gum	gum	NN
cord-295807-68sukdb1	912	33	on	on	IN
cord-295807-68sukdb1	912	34	the	the	DT
cord-295807-68sukdb1	912	35	Salivary	Salivary	NNP
cord-295807-68sukdb1	912	36	pH	ph	NN
cord-295807-68sukdb1	912	37	:	:	:
cord-295807-68sukdb1	913	1	An	an	DT
cord-295807-68sukdb1	913	2	in	in	IN
cord-295807-68sukdb1	913	3	vivo	vivo	NNP
cord-295807-68sukdb1	913	4	Study	Study	NNP
cord-295807-68sukdb1	913	5	Sodium	Sodium	NNP
cord-295807-68sukdb1	913	6	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	913	7	Solution	Solution	NNP
cord-295807-68sukdb1	913	8	versus	versus	IN
cord-295807-68sukdb1	913	9	Chlorhexidine	Chlorhexidine	NNP
cord-295807-68sukdb1	913	10	Mouthwash	Mouthwash	NNP
cord-295807-68sukdb1	913	11	in	in	IN
cord-295807-68sukdb1	913	12	Oral	Oral	NNP
cord-295807-68sukdb1	913	13	Care	Care	NNP
cord-295807-68sukdb1	913	14	of	of	IN
cord-295807-68sukdb1	913	15	Acute	Acute	NNP
cord-295807-68sukdb1	913	16	Leukemia	Leukemia	NNP
cord-295807-68sukdb1	913	17	Patients	patient	NNS
cord-295807-68sukdb1	913	18	Undergoing	Undergoing	NNP
cord-295807-68sukdb1	913	19	Induction	Induction	NNP
cord-295807-68sukdb1	913	20	Chemotherapy	Chemotherapy	NNP
cord-295807-68sukdb1	913	21	:	:	:
cord-295807-68sukdb1	914	1	A	a	DT
cord-295807-68sukdb1	914	2	Randomized	Randomized	NNP
cord-295807-68sukdb1	914	3	Controlled	Controlled	NNP
cord-295807-68sukdb1	914	4	Trial	trial	NN
cord-295807-68sukdb1	915	1	The	the	DT
cord-295807-68sukdb1	915	2	effect	effect	NN
cord-295807-68sukdb1	915	3	of	of	IN
cord-295807-68sukdb1	915	4	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	915	5	/	/	SYM
cord-295807-68sukdb1	915	6	fluoride	fluoride	NN
cord-295807-68sukdb1	915	7	dentifrices	dentifrice	NNS
cord-295807-68sukdb1	915	8	on	on	IN
cord-295807-68sukdb1	915	9	human	human	JJ
cord-295807-68sukdb1	915	10	plaque	plaque	NN
cord-295807-68sukdb1	915	11	pH	pH	NNP
cord-295807-68sukdb1	915	12	Enhancement	Enhancement	NNP
cord-295807-68sukdb1	915	13	of	of	IN
cord-295807-68sukdb1	915	14	plaque	plaque	NN
cord-295807-68sukdb1	915	15	removal	removal	NN
cord-295807-68sukdb1	915	16	efficacy	efficacy	NN
cord-295807-68sukdb1	915	17	by	by	IN
cord-295807-68sukdb1	915	18	tooth	tooth	NN
cord-295807-68sukdb1	915	19	brushing	brushing	NN
cord-295807-68sukdb1	915	20	with	with	IN
cord-295807-68sukdb1	915	21	baking	baking	NN
cord-295807-68sukdb1	915	22	soda	soda	NN
cord-295807-68sukdb1	915	23	dentifrices	dentifrice	NNS
cord-295807-68sukdb1	915	24	:	:	:
cord-295807-68sukdb1	915	25	results	result	NNS
cord-295807-68sukdb1	915	26	of	of	IN
cord-295807-68sukdb1	915	27	five	five	CD
cord-295807-68sukdb1	915	28	clinical	clinical	JJ
cord-295807-68sukdb1	915	29	studies	study	NNS
cord-295807-68sukdb1	915	30	Bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	915	31	-	-	HYPH
cord-295807-68sukdb1	915	32	based	base	VBN
cord-295807-68sukdb1	915	33	powder	powder	NN
cord-295807-68sukdb1	915	34	and	and	CC
cord-295807-68sukdb1	915	35	paste	paste	VB
cord-295807-68sukdb1	915	36	dentifrice	dentifrice	NN
cord-295807-68sukdb1	915	37	effects	effect	NNS
cord-295807-68sukdb1	915	38	on	on	IN
cord-295807-68sukdb1	915	39	caries	caries	NN
cord-295807-68sukdb1	915	40	pH	ph	NN
cord-295807-68sukdb1	915	41	stabilizing	stabilize	VBG
cord-295807-68sukdb1	915	42	properties	property	NNS
cord-295807-68sukdb1	915	43	of	of	IN
cord-295807-68sukdb1	915	44	a	a	DT
cord-295807-68sukdb1	915	45	posterior	posterior	JJ
cord-295807-68sukdb1	915	46	light	light	NN
cord-295807-68sukdb1	915	47	cured	cure	VBN
cord-295807-68sukdb1	915	48	resin	resin	NN
cord-295807-68sukdb1	915	49	composite	composite	NN
cord-295807-68sukdb1	915	50	:	:	:
cord-295807-68sukdb1	915	51	an	an	DT
cord-295807-68sukdb1	915	52	in	in	IN
cord-295807-68sukdb1	915	53	vivo	vivo	NN
cord-295807-68sukdb1	915	54	study	study	NN
cord-295807-68sukdb1	915	55	Six	six	CD
cord-295807-68sukdb1	915	56	months	month	NNS
cord-295807-68sukdb1	915	57	of	of	IN
cord-295807-68sukdb1	915	58	daily	daily	JJ
cord-295807-68sukdb1	915	59	high	high	JJ
cord-295807-68sukdb1	915	60	-	-	HYPH
cord-295807-68sukdb1	915	61	dose	dose	NN
cord-295807-68sukdb1	915	62	xylitol	xylitol	NN
cord-295807-68sukdb1	915	63	in	in	IN
cord-295807-68sukdb1	915	64	high	high	JJ
cord-295807-68sukdb1	915	65	-	-	HYPH
cord-295807-68sukdb1	915	66	risk	risk	NN
cord-295807-68sukdb1	915	67	schoolchildren	schoolchildren	NNS
cord-295807-68sukdb1	915	68	:	:	:
cord-295807-68sukdb1	915	69	a	a	DT
cord-295807-68sukdb1	915	70	randomized	randomized	JJ
cord-295807-68sukdb1	915	71	clinical	clinical	JJ
cord-295807-68sukdb1	915	72	trial	trial	NN
cord-295807-68sukdb1	915	73	on	on	IN
cord-295807-68sukdb1	915	74	plaque	plaque	NN
cord-295807-68sukdb1	915	75	pH	ph	NN
cord-295807-68sukdb1	915	76	and	and	CC
cord-295807-68sukdb1	915	77	salivary	salivary	JJ
cord-295807-68sukdb1	915	78	mutans	mutan	NNS
cord-295807-68sukdb1	915	79	streptococci	streptococcus	NNS
cord-295807-68sukdb1	916	1	The	the	DT
cord-295807-68sukdb1	916	2	Influence	influence	NN
cord-295807-68sukdb1	916	3	of	of	IN
cord-295807-68sukdb1	916	4	Virus	Virus	NNP
cord-295807-68sukdb1	916	5	Infection	Infection	NNP
cord-295807-68sukdb1	916	6	on	on	IN
cord-295807-68sukdb1	916	7	the	the	DT
cord-295807-68sukdb1	916	8	Extracellular	Extracellular	NNP
cord-295807-68sukdb1	916	9	pH	pH	NNP
cord-295807-68sukdb1	916	10	of	of	IN
cord-295807-68sukdb1	916	11	the	the	DT
cord-295807-68sukdb1	916	12	Host	Host	NNP
cord-295807-68sukdb1	916	13	Carbon	Carbon	NNP
cord-295807-68sukdb1	916	14	dioxide	dioxide	NN
cord-295807-68sukdb1	916	15	instantly	instantly	RB
cord-295807-68sukdb1	916	16	sensitizes	sensitize	VBZ
cord-295807-68sukdb1	916	17	female	female	JJ
cord-295807-68sukdb1	916	18	yellow	yellow	JJ
cord-295807-68sukdb1	916	19	fever	fever	NN
cord-295807-68sukdb1	916	20	mosquitoes	mosquito	NNS
cord-295807-68sukdb1	916	21	to	to	IN
cord-295807-68sukdb1	916	22	human	human	JJ
cord-295807-68sukdb1	916	23	skin	skin	NN
cord-295807-68sukdb1	916	24	odours	odour	NNS
cord-295807-68sukdb1	916	25	Merozoite	Merozoite	NNP
cord-295807-68sukdb1	916	26	surface	surface	NN
cord-295807-68sukdb1	916	27	protein	protein	NN
cord-295807-68sukdb1	916	28	1	1	CD
cord-295807-68sukdb1	916	29	recognition	recognition	NN
cord-295807-68sukdb1	916	30	of	of	IN
cord-295807-68sukdb1	917	1	host	host	NN
cord-295807-68sukdb1	917	2	glycophorin	glycophorin	NNP
cord-295807-68sukdb1	917	3	A	A	NNP
cord-295807-68sukdb1	917	4	mediates	mediate	VBZ
cord-295807-68sukdb1	917	5	malaria	malaria	NN
cord-295807-68sukdb1	917	6	parasite	parasite	NN
cord-295807-68sukdb1	917	7	invasion	invasion	NN
cord-295807-68sukdb1	917	8	of	of	IN
cord-295807-68sukdb1	917	9	red	red	JJ
cord-295807-68sukdb1	917	10	blood	blood	NN
cord-295807-68sukdb1	917	11	cells	cell	NNS
cord-295807-68sukdb1	918	1	Reduced	reduce	VBN
cord-295807-68sukdb1	918	2	risk	risk	NN
cord-295807-68sukdb1	918	3	of	of	IN
cord-295807-68sukdb1	918	4	Plasmodium	Plasmodium	NNP
cord-295807-68sukdb1	918	5	vivax	vivax	JJ
cord-295807-68sukdb1	918	6	malaria	malaria	NN
cord-295807-68sukdb1	918	7	in	in	IN
cord-295807-68sukdb1	918	8	Papua	Papua	NNP
cord-295807-68sukdb1	918	9	New	New	NNP
cord-295807-68sukdb1	918	10	Guinean	guinean	JJ
cord-295807-68sukdb1	918	11	children	child	NNS
cord-295807-68sukdb1	918	12	with	with	IN
cord-295807-68sukdb1	918	13	Southeast	southeast	JJ
cord-295807-68sukdb1	918	14	Asian	asian	JJ
cord-295807-68sukdb1	918	15	ovalocytosis	ovalocytosis	NN
cord-295807-68sukdb1	918	16	in	in	IN
cord-295807-68sukdb1	918	17	two	two	CD
cord-295807-68sukdb1	918	18	cohorts	cohort	NNS
cord-295807-68sukdb1	918	19	and	and	CC
cord-295807-68sukdb1	918	20	a	a	DT
cord-295807-68sukdb1	918	21	case	case	NN
cord-295807-68sukdb1	918	22	-	-	HYPH
cord-295807-68sukdb1	918	23	control	control	NN
cord-295807-68sukdb1	918	24	study	study	NN
cord-295807-68sukdb1	919	1	The	the	DT
cord-295807-68sukdb1	919	2	pathophysiologic	pathophysiologic	JJ
cord-295807-68sukdb1	919	3	and	and	CC
cord-295807-68sukdb1	919	4	prognostic	prognostic	JJ
cord-295807-68sukdb1	919	5	significance	significance	NN
cord-295807-68sukdb1	919	6	of	of	IN
cord-295807-68sukdb1	919	7	acidosis	acidosis	NN
cord-295807-68sukdb1	919	8	in	in	IN
cord-295807-68sukdb1	919	9	severe	severe	JJ
cord-295807-68sukdb1	919	10	adult	adult	NN
cord-295807-68sukdb1	919	11	malaria	malaria	NN
cord-295807-68sukdb1	919	12	Unidentified	unidentified	JJ
cord-295807-68sukdb1	919	13	acids	acid	NNS
cord-295807-68sukdb1	919	14	of	of	IN
cord-295807-68sukdb1	919	15	strong	strong	JJ
cord-295807-68sukdb1	919	16	prognostic	prognostic	JJ
cord-295807-68sukdb1	919	17	significance	significance	NN
cord-295807-68sukdb1	919	18	in	in	IN
cord-295807-68sukdb1	919	19	severe	severe	JJ
cord-295807-68sukdb1	919	20	malaria	malaria	NN
cord-295807-68sukdb1	919	21	Put	put	VB
cord-295807-68sukdb1	919	22	a	a	DT
cord-295807-68sukdb1	919	23	cork	cork	NN
cord-295807-68sukdb1	919	24	in	in	IN
cord-295807-68sukdb1	919	25	it	-PRON-	PRP
cord-295807-68sukdb1	919	26	:	:	:
cord-295807-68sukdb1	919	27	Plugging	plug	VBG
cord-295807-68sukdb1	919	28	the	the	DT
cord-295807-68sukdb1	919	29	M2	m2	JJ
cord-295807-68sukdb1	919	30	viral	viral	JJ
cord-295807-68sukdb1	919	31	ion	ion	NN
cord-295807-68sukdb1	919	32	channel	channel	NN
cord-295807-68sukdb1	919	33	to	to	TO
cord-295807-68sukdb1	919	34	sink	sink	VB
cord-295807-68sukdb1	919	35	influenza	influenza	NN
cord-295807-68sukdb1	919	36	Proton	proton	NN
cord-295807-68sukdb1	919	37	Pump	Pump	NNP
cord-295807-68sukdb1	919	38	Inhibitors	Inhibitors	NNPS
cord-295807-68sukdb1	919	39	are	be	VBP
cord-295807-68sukdb1	919	40	Risk	risk	NN
cord-295807-68sukdb1	919	41	Factors	factor	NNS
cord-295807-68sukdb1	919	42	for	for	IN
cord-295807-68sukdb1	919	43	Viral	Viral	NNP
cord-295807-68sukdb1	919	44	Infections	Infections	NNPS
cord-295807-68sukdb1	919	45	:	:	:
cord-295807-68sukdb1	919	46	Even	even	RB
cord-295807-68sukdb1	919	47	for	for	IN
cord-295807-68sukdb1	919	48	COVID-19	covid-19	NN
cord-295807-68sukdb1	919	49	?	?	.
cord-295807-68sukdb1	920	1	Pharmacokinetics	pharmacokinetic	NNS
cord-295807-68sukdb1	920	2	and	and	CC
cord-295807-68sukdb1	920	3	pharmacodynamics	pharmacodynamic	NNS
cord-295807-68sukdb1	920	4	of	of	IN
cord-295807-68sukdb1	920	5	dichloroacetate	dichloroacetate	NN
cord-295807-68sukdb1	920	6	in	in	IN
cord-295807-68sukdb1	920	7	children	child	NNS
cord-295807-68sukdb1	920	8	with	with	IN
cord-295807-68sukdb1	920	9	lactic	lactic	JJ
cord-295807-68sukdb1	920	10	acidosis	acidosis	NN
cord-295807-68sukdb1	920	11	due	due	IN
cord-295807-68sukdb1	920	12	to	to	IN
cord-295807-68sukdb1	920	13	severe	severe	JJ
cord-295807-68sukdb1	920	14	malaria	malaria	NN
cord-295807-68sukdb1	920	15	Can	Can	MD
cord-295807-68sukdb1	920	16	exchange	exchange	VB
cord-295807-68sukdb1	920	17	transfusions	transfusion	NNS
cord-295807-68sukdb1	920	18	using	use	VBG
cord-295807-68sukdb1	920	19	red	red	JJ
cord-295807-68sukdb1	920	20	blood	blood	NN
cord-295807-68sukdb1	920	21	cells	cell	NNS
cord-295807-68sukdb1	920	22	from	from	IN
cord-295807-68sukdb1	920	23	donors	donor	NNS
cord-295807-68sukdb1	920	24	with	with	IN
cord-295807-68sukdb1	920	25	Southeast	southeast	JJ
cord-295807-68sukdb1	920	26	Asian	asian	JJ
cord-295807-68sukdb1	920	27	ovalocytosis	ovalocytosis	NN
cord-295807-68sukdb1	920	28	prevent	prevent	VBP
cord-295807-68sukdb1	920	29	or	or	CC
cord-295807-68sukdb1	920	30	ameliorate	ameliorate	VB
cord-295807-68sukdb1	920	31	cerebral	cerebral	JJ
cord-295807-68sukdb1	920	32	malaria	malaria	NN
cord-295807-68sukdb1	920	33	in	in	IN
cord-295807-68sukdb1	920	34	patients	patient	NNS
cord-295807-68sukdb1	920	35	with	with	IN
cord-295807-68sukdb1	920	36	multi	multi	JJ
cord-295807-68sukdb1	920	37	-	-	JJ
cord-295807-68sukdb1	920	38	drug	drug	JJ
cord-295807-68sukdb1	920	39	resistant	resistant	JJ
cord-295807-68sukdb1	920	40	Plasmodium	Plasmodium	NNP
cord-295807-68sukdb1	920	41	falciparum	falciparum	NN
cord-295807-68sukdb1	920	42	?	?	.
cord-295807-68sukdb1	921	1	Na(+	Na(+	NNP
cord-295807-68sukdb1	921	2	)	)	-RRB-
cord-295807-68sukdb1	921	3	regulation	regulation	NN
cord-295807-68sukdb1	921	4	in	in	IN
cord-295807-68sukdb1	921	5	the	the	DT
cord-295807-68sukdb1	921	6	malaria	malaria	NN
cord-295807-68sukdb1	921	7	parasite	parasite	NN
cord-295807-68sukdb1	921	8	Plasmodium	Plasmodium	NNP
cord-295807-68sukdb1	921	9	falciparum	falciparum	NN
cord-295807-68sukdb1	921	10	involves	involve	VBZ
cord-295807-68sukdb1	921	11	the	the	DT
cord-295807-68sukdb1	921	12	cation	cation	NN
cord-295807-68sukdb1	921	13	ATPase	ATPase	NNP
cord-295807-68sukdb1	921	14	PfATP4	PfATP4	NNP
cord-295807-68sukdb1	921	15	and	and	CC
cord-295807-68sukdb1	921	16	is	be	VBZ
cord-295807-68sukdb1	921	17	a	a	DT
cord-295807-68sukdb1	921	18	target	target	NN
cord-295807-68sukdb1	921	19	of	of	IN
cord-295807-68sukdb1	921	20	the	the	DT
cord-295807-68sukdb1	921	21	spiroindolone	spiroindolone	NN
cord-295807-68sukdb1	921	22	antimalarials	antimalarial	NNS
cord-295807-68sukdb1	921	23	The	the	DT
cord-295807-68sukdb1	921	24	Warburg	Warburg	NNP
cord-295807-68sukdb1	921	25	Effect	effect	NN
cord-295807-68sukdb1	921	26	:	:	:
cord-295807-68sukdb1	921	27	How	how	WRB
cord-295807-68sukdb1	921	28	Does	do	VBZ
cord-295807-68sukdb1	921	29	it	-PRON-	PRP
cord-295807-68sukdb1	921	30	Benefit	benefit	VB
cord-295807-68sukdb1	921	31	Cancer	cancer	NN
cord-295807-68sukdb1	921	32	Cells	cell	NNS
cord-295807-68sukdb1	921	33	?	?	.
cord-295807-68sukdb1	922	1	We	-PRON-	PRP
cord-295807-68sukdb1	922	2	need	need	VBP
cord-295807-68sukdb1	922	3	to	to	TO
cord-295807-68sukdb1	922	4	talk	talk	VB
cord-295807-68sukdb1	922	5	about	about	IN
cord-295807-68sukdb1	922	6	the	the	DT
cord-295807-68sukdb1	922	7	Warburg	Warburg	NNP
cord-295807-68sukdb1	922	8	effect	effect	NN
cord-295807-68sukdb1	922	9	pH	ph	NN
cord-295807-68sukdb1	922	10	control	control	NN
cord-295807-68sukdb1	922	11	mechanisms	mechanism	NNS
cord-295807-68sukdb1	922	12	of	of	IN
cord-295807-68sukdb1	922	13	tumor	tumor	NN
cord-295807-68sukdb1	922	14	survival	survival	NN
cord-295807-68sukdb1	922	15	and	and	CC
cord-295807-68sukdb1	922	16	growth	growth	NN
cord-295807-68sukdb1	922	17	Regulation	regulation	NN
cord-295807-68sukdb1	922	18	and	and	CC
cord-295807-68sukdb1	922	19	roles	role	NNS
cord-295807-68sukdb1	922	20	of	of	IN
cord-295807-68sukdb1	922	21	bicarbonate	bicarbonate	NN
cord-295807-68sukdb1	922	22	transporters	transporter	NNS
cord-295807-68sukdb1	922	23	in	in	IN
cord-295807-68sukdb1	922	24	cancer	cancer	NN
cord-295807-68sukdb1	922	25	Role	role	NN
cord-295807-68sukdb1	922	26	of	of	IN
cord-295807-68sukdb1	922	27	pH	pH	NNP
cord-295807-68sukdb1	922	28	Regulatory	Regulatory	NNP
cord-295807-68sukdb1	922	29	Proteins	Proteins	NNPS
cord-295807-68sukdb1	922	30	and	and	CC
cord-295807-68sukdb1	922	31	Dysregulation	Dysregulation	NNP
cord-295807-68sukdb1	922	32	of	of	IN
cord-295807-68sukdb1	922	33	pH	pH	NNP
cord-295807-68sukdb1	922	34	in	in	IN
cord-295807-68sukdb1	922	35	Prostate	Prostate	NNP
cord-295807-68sukdb1	922	36	Cancer	Cancer	NNP
cord-295807-68sukdb1	922	37	Disrupting	disrupting	NN
cord-295807-68sukdb1	923	1	Hypoxia	hypoxia	NN
cord-295807-68sukdb1	923	2	-	-	HYPH
cord-295807-68sukdb1	923	3	Induced	Induced	NNP
cord-295807-68sukdb1	923	4	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	923	5	Transport	Transport	NNP
cord-295807-68sukdb1	923	6	Acidifies	Acidifies	NNP
cord-295807-68sukdb1	923	7	Tumor	tumor	NN
cord-295807-68sukdb1	923	8	Cells	cell	NNS
cord-295807-68sukdb1	923	9	and	and	CC
cord-295807-68sukdb1	923	10	Suppresses	suppress	VBZ
cord-295807-68sukdb1	923	11	Tumor	tumor	NN
cord-295807-68sukdb1	923	12	Growth	growth	NN
cord-295807-68sukdb1	923	13	Carbonic	Carbonic	NNP
cord-295807-68sukdb1	923	14	Anhydrases	anhydrase	NNS
cord-295807-68sukdb1	923	15	:	:	:
cord-295807-68sukdb1	924	1	Role	role	NN
cord-295807-68sukdb1	924	2	in	in	IN
cord-295807-68sukdb1	924	3	pH	pH	NNP
cord-295807-68sukdb1	924	4	Control	Control	NNP
cord-295807-68sukdb1	924	5	and	and	CC
cord-295807-68sukdb1	924	6	Cancer	Cancer	NNP
cord-295807-68sukdb1	924	7	Sharpey	Sharpey	NNP
cord-295807-68sukdb1	924	8	-	-	HYPH
cord-295807-68sukdb1	924	9	Schafer	Schafer	NNP
cord-295807-68sukdb1	924	10	lecture	lecture	NN
cord-295807-68sukdb1	924	11	:	:	:
cord-295807-68sukdb1	924	12	gas	gas	NN
cord-295807-68sukdb1	924	13	channels	channel	NNS
cord-295807-68sukdb1	924	14	Rapid	Rapid	NNP
cord-295807-68sukdb1	924	15	CO2	CO2	NNP
cord-295807-68sukdb1	924	16	permeation	permeation	NN
cord-295807-68sukdb1	924	17	across	across	IN
cord-295807-68sukdb1	924	18	biological	biological	JJ
cord-295807-68sukdb1	924	19	membranes	membrane	NNS
cord-295807-68sukdb1	924	20	:	:	:
cord-295807-68sukdb1	924	21	implications	implication	NNS
cord-295807-68sukdb1	924	22	for	for	IN
cord-295807-68sukdb1	924	23	CO2	co2	NN
cord-295807-68sukdb1	924	24	venting	venting	NN
cord-295807-68sukdb1	924	25	from	from	IN
cord-295807-68sukdb1	924	26	tissue	tissue	NN
cord-295807-68sukdb1	924	27	Water	water	NN
cord-295807-68sukdb1	924	28	transport	transport	NN
cord-295807-68sukdb1	924	29	proteins	protein	NNS
cord-295807-68sukdb1	924	30	-	-	HYPH
cord-295807-68sukdb1	924	31	aquaporins	aquaporin	NNS
cord-295807-68sukdb1	924	32	(	(	-LRB-
cord-295807-68sukdb1	924	33	AQPs	AQPs	NNP
cord-295807-68sukdb1	924	34	)	)	-RRB-
cord-295807-68sukdb1	924	35	in	in	IN
cord-295807-68sukdb1	924	36	cancer	cancer	NN
cord-295807-68sukdb1	924	37	biology	biology	NN
cord-295807-68sukdb1	924	38	Acidosis	acidosis	NN
cord-295807-68sukdb1	924	39	induces	induce	VBZ
cord-295807-68sukdb1	924	40	reprogramming	reprogramming	NN
cord-295807-68sukdb1	924	41	of	of	IN
cord-295807-68sukdb1	924	42	cellular	cellular	JJ
cord-295807-68sukdb1	924	43	metabolism	metabolism	NN
cord-295807-68sukdb1	924	44	to	to	TO
cord-295807-68sukdb1	924	45	mitigate	mitigate	VB
cord-295807-68sukdb1	924	46	oxidative	oxidative	JJ
cord-295807-68sukdb1	924	47	stress	stress	NN
cord-295807-68sukdb1	925	1	The	the	DT
cord-295807-68sukdb1	925	2	Acidic	acidic	JJ
cord-295807-68sukdb1	925	3	Tumor	tumor	NN
cord-295807-68sukdb1	925	4	Microenvironment	Microenvironment	NNP
cord-295807-68sukdb1	925	5	as	as	IN
cord-295807-68sukdb1	925	6	a	a	DT
cord-295807-68sukdb1	925	7	Driver	Driver	NNP
cord-295807-68sukdb1	925	8	of	of	IN
cord-295807-68sukdb1	925	9	Cancer	Cancer	NNP
cord-295807-68sukdb1	925	10	Tumor	Tumor	NNP
cord-295807-68sukdb1	925	11	immunoevasion	immunoevasion	NN
cord-295807-68sukdb1	925	12	via	via	IN
cord-295807-68sukdb1	925	13	acidosis	acidosis	NN
cord-295807-68sukdb1	925	14	-	-	HYPH
cord-295807-68sukdb1	925	15	dependent	dependent	JJ
cord-295807-68sukdb1	925	16	induction	induction	NN
cord-295807-68sukdb1	925	17	of	of	IN
cord-295807-68sukdb1	925	18	regulatory	regulatory	JJ
cord-295807-68sukdb1	925	19	tumor	tumor	NN
cord-295807-68sukdb1	925	20	-	-	HYPH
cord-295807-68sukdb1	925	21	associated	associate	VBN
cord-295807-68sukdb1	925	22	macrophages	macrophage	NNS
cord-295807-68sukdb1	925	23	Increased	increase	VBD
cord-295807-68sukdb1	925	24	Acid	acid	NN
cord-295807-68sukdb1	925	25	-	-	HYPH
cord-295807-68sukdb1	925	26	Producing	produce	VBG
cord-295807-68sukdb1	925	27	Diet	Diet	NNP
cord-295807-68sukdb1	925	28	and	and	CC
cord-295807-68sukdb1	925	29	Past	past	JJ
cord-295807-68sukdb1	925	30	Smoking	smoking	NN
cord-295807-68sukdb1	925	31	Intensity	intensity	NN
cord-295807-68sukdb1	925	32	Are	be	VBP
cord-295807-68sukdb1	925	33	Associated	associate	VBN
cord-295807-68sukdb1	925	34	with	with	IN
cord-295807-68sukdb1	925	35	Worse	bad	JJR
cord-295807-68sukdb1	925	36	Prognoses	prognosis	NNS
cord-295807-68sukdb1	925	37	among	among	IN
cord-295807-68sukdb1	925	38	Breast	Breast	NNP
cord-295807-68sukdb1	925	39	Cancer	Cancer	NNP
cord-295807-68sukdb1	925	40	Survivors	Survivors	NNPS
cord-295807-68sukdb1	925	41	:	:	:
cord-295807-68sukdb1	926	1	A	a	DT
cord-295807-68sukdb1	926	2	Prospective	Prospective	NNP
cord-295807-68sukdb1	926	3	Cohort	Cohort	NNP
cord-295807-68sukdb1	926	4	Study	Study	NNP
cord-295807-68sukdb1	926	5	Acid	Acid	NNP
cord-295807-68sukdb1	926	6	treatment	treatment	NN
cord-295807-68sukdb1	926	7	of	of	IN
cord-295807-68sukdb1	926	8	melanoma	melanoma	NN
cord-295807-68sukdb1	926	9	cells	cell	NNS
cord-295807-68sukdb1	926	10	selects	select	VBZ
cord-295807-68sukdb1	926	11	for	for	IN
cord-295807-68sukdb1	926	12	invasive	invasive	JJ
cord-295807-68sukdb1	926	13	phenotypes	phenotype	NNS
cord-295807-68sukdb1	927	1	The	the	DT
cord-295807-68sukdb1	927	2	Hypoxic	Hypoxic	NNP
cord-295807-68sukdb1	927	3	Response	Response	NNP
cord-295807-68sukdb1	927	4	Expression	Expression	NNP
cord-295807-68sukdb1	927	5	as	as	IN
cord-295807-68sukdb1	927	6	a	a	DT
cord-295807-68sukdb1	927	7	Survival	Survival	NNP
cord-295807-68sukdb1	927	8	Biomarkers	Biomarkers	NNPS
cord-295807-68sukdb1	927	9	in	in	IN
cord-295807-68sukdb1	927	10	Treatment	treatment	NN
cord-295807-68sukdb1	927	11	-	-	HYPH
cord-295807-68sukdb1	927	12	Naive	Naive	NNP
cord-295807-68sukdb1	927	13	Advanced	Advanced	NNP
cord-295807-68sukdb1	927	14	Breast	Breast	NNP
cord-295807-68sukdb1	927	15	Cancer	Cancer	NNP
cord-295807-68sukdb1	927	16	,	,	,
cord-295807-68sukdb1	927	17	Asian	Asian	NNP
cord-295807-68sukdb1	927	18	Pac	Pac	NNP
cord-295807-68sukdb1	927	19	Increased	increase	VBN
cord-295807-68sukdb1	927	20	expression	expression	NN
cord-295807-68sukdb1	927	21	of	of	IN
cord-295807-68sukdb1	927	22	Na+/H+	Na+/H+	NNP
cord-295807-68sukdb1	927	23	exchanger	exchanger	NN
cord-295807-68sukdb1	927	24	isoform	isoform	NN
cord-295807-68sukdb1	927	25	1	1	CD
cord-295807-68sukdb1	927	26	predicts	predict	VBZ
cord-295807-68sukdb1	927	27	tumor	tumor	NN
cord-295807-68sukdb1	927	28	aggressiveness	aggressiveness	NN
cord-295807-68sukdb1	927	29	and	and	CC
cord-295807-68sukdb1	927	30	unfavorable	unfavorable	JJ
cord-295807-68sukdb1	927	31	prognosis	prognosis	NN
cord-295807-68sukdb1	927	32	in	in	IN
cord-295807-68sukdb1	927	33	epithelial	epithelial	JJ
cord-295807-68sukdb1	927	34	ovarian	ovarian	JJ
cord-295807-68sukdb1	927	35	cancer	cancer	NN
cord-295807-68sukdb1	927	36	Monocarboxylate	Monocarboxylate	NNP
cord-295807-68sukdb1	927	37	transporters	transporter	NNS
cord-295807-68sukdb1	927	38	in	in	IN
cord-295807-68sukdb1	927	39	breast	breast	NN
cord-295807-68sukdb1	927	40	cancer	cancer	NN
cord-295807-68sukdb1	927	41	and	and	CC
cord-295807-68sukdb1	927	42	adipose	adipose	JJ
cord-295807-68sukdb1	927	43	tissue	tissue	NN
cord-295807-68sukdb1	927	44	are	be	VBP
cord-295807-68sukdb1	927	45	novel	novel	JJ
cord-295807-68sukdb1	927	46	biomarkers	biomarker	NNS
cord-295807-68sukdb1	927	47	and	and	CC
cord-295807-68sukdb1	927	48	potential	potential	JJ
cord-295807-68sukdb1	927	49	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	927	50	targets	target	NNS
cord-295807-68sukdb1	928	1	Cellular	cellular	JJ
cord-295807-68sukdb1	928	2	acidification	acidification	NN
cord-295807-68sukdb1	928	3	as	as	IN
cord-295807-68sukdb1	928	4	a	a	DT
cord-295807-68sukdb1	928	5	new	new	JJ
cord-295807-68sukdb1	928	6	approach	approach	NN
cord-295807-68sukdb1	928	7	to	to	IN
cord-295807-68sukdb1	928	8	cancer	cancer	NN
cord-295807-68sukdb1	928	9	treatment	treatment	NN
cord-295807-68sukdb1	928	10	and	and	CC
cord-295807-68sukdb1	928	11	to	to	IN
cord-295807-68sukdb1	928	12	the	the	DT
cord-295807-68sukdb1	928	13	understanding	understanding	NN
cord-295807-68sukdb1	928	14	and	and	CC
cord-295807-68sukdb1	928	15	therapeutics	therapeutic	NNS
cord-295807-68sukdb1	928	16	of	of	IN
cord-295807-68sukdb1	928	17	neurodegenerative	neurodegenerative	JJ
cord-295807-68sukdb1	928	18	diseases	disease	NNS
cord-295807-68sukdb1	928	19	Disrupting	disrupt	VBG
cord-295807-68sukdb1	928	20	Na	Na	NNP
cord-295807-68sukdb1	928	21	+	+	CC
cord-295807-68sukdb1	928	22	,	,	.
cord-295807-68sukdb1	929	1	HCO₃	HCO₃	NNP
cord-295807-68sukdb1	929	2	−	−	NNP
cord-295807-68sukdb1	929	3	-cotransporter	-cotransporter	.
cord-295807-68sukdb1	930	1	NBCn1	NBCn1	NNP
cord-295807-68sukdb1	930	2	(	(	-LRB-
cord-295807-68sukdb1	930	3	Slc4a7	Slc4a7	NNP
cord-295807-68sukdb1	930	4	)	)	-RRB-
cord-295807-68sukdb1	930	5	delays	delay	VBZ
cord-295807-68sukdb1	930	6	murine	murine	JJ
cord-295807-68sukdb1	930	7	breast	breast	NN
cord-295807-68sukdb1	930	8	cancer	cancer	NN
cord-295807-68sukdb1	930	9	development	development	NN
cord-295807-68sukdb1	931	1	Intermittent	intermittent	JJ
cord-295807-68sukdb1	931	2	high	high	JJ
cord-295807-68sukdb1	931	3	dose	dose	NN
cord-295807-68sukdb1	931	4	proton	proton	NN
cord-295807-68sukdb1	931	5	pump	pump	NN
cord-295807-68sukdb1	931	6	inhibitor	inhibitor	NN
cord-295807-68sukdb1	931	7	enhances	enhance	VBZ
cord-295807-68sukdb1	931	8	the	the	DT
cord-295807-68sukdb1	931	9	antitumor	antitumor	JJ
cord-295807-68sukdb1	931	10	effects	effect	NNS
cord-295807-68sukdb1	931	11	of	of	IN
cord-295807-68sukdb1	931	12	chemotherapy	chemotherapy	NN
cord-295807-68sukdb1	931	13	in	in	IN
cord-295807-68sukdb1	931	14	metastatic	metastatic	JJ
cord-295807-68sukdb1	931	15	breast	breast	NN
cord-295807-68sukdb1	931	16	cancer	cancer	NN
cord-295807-68sukdb1	931	17	Development	Development	NNP
cord-295807-68sukdb1	931	18	of	of	IN
cord-295807-68sukdb1	931	19	a	a	DT
cord-295807-68sukdb1	931	20	Small	Small	NNP
cord-295807-68sukdb1	931	21	Molecule	Molecule	NNP
cord-295807-68sukdb1	931	22	Tubulysin	Tubulysin	NNP
cord-295807-68sukdb1	931	23	B	B	NNP
cord-295807-68sukdb1	931	24	Conjugate	Conjugate	NNP
cord-295807-68sukdb1	931	25	for	for	IN
cord-295807-68sukdb1	931	26	Treatment	treatment	NN
cord-295807-68sukdb1	931	27	of	of	IN
cord-295807-68sukdb1	931	28	Carbonic	Carbonic	NNP
cord-295807-68sukdb1	931	29	Anhydrase	Anhydrase	NNP
cord-295807-68sukdb1	931	30	IX	IX	NNP
cord-295807-68sukdb1	931	31	Receptor	receptor	NN
cord-295807-68sukdb1	931	32	Expressing	Expressing	NNP
cord-295807-68sukdb1	931	33	Cancers	Cancers	NNPS
cord-295807-68sukdb1	931	34	Brain	Brain	NNP
cord-295807-68sukdb1	931	35	tumor	tumor	NN
cord-295807-68sukdb1	931	36	acidification	acidification	NN
cord-295807-68sukdb1	931	37	using	use	VBG
cord-295807-68sukdb1	931	38	drugs	drug	NNS
cord-295807-68sukdb1	931	39	simultaneously	simultaneously	RB
cord-295807-68sukdb1	931	40	targeting	target	VBG
cord-295807-68sukdb1	931	41	multiple	multiple	JJ
cord-295807-68sukdb1	931	42	pH	pH	NNP
cord-295807-68sukdb1	931	43	regulatory	regulatory	JJ
cord-295807-68sukdb1	931	44	mechanisms	mechanism	NNS
cord-295807-68sukdb1	931	45	Glucose	glucose	NN
cord-295807-68sukdb1	931	46	-	-	HYPH
cord-295807-68sukdb1	931	47	dependent	dependent	JJ
cord-295807-68sukdb1	931	48	growth	growth	NN
cord-295807-68sukdb1	931	49	arrest	arrest	NN
cord-295807-68sukdb1	931	50	of	of	IN
cord-295807-68sukdb1	931	51	leukemia	leukemia	NN
cord-295807-68sukdb1	931	52	cells	cell	NNS
cord-295807-68sukdb1	931	53	by	by	IN
cord-295807-68sukdb1	931	54	MCT1	MCT1	NNP
cord-295807-68sukdb1	931	55	inhibition	inhibition	NN
cord-295807-68sukdb1	931	56	:	:	:
cord-295807-68sukdb1	931	57	Feeding	feed	VBG
cord-295807-68sukdb1	931	58	Warburg	Warburg	NNP
cord-295807-68sukdb1	931	59	's	's	POS
cord-295807-68sukdb1	931	60	sweet	sweet	JJ
cord-295807-68sukdb1	931	61	tooth	tooth	NN
cord-295807-68sukdb1	931	62	and	and	CC
cord-295807-68sukdb1	931	63	blocking	block	VBG
cord-295807-68sukdb1	931	64	acid	acid	JJ
cord-295807-68sukdb1	931	65	export	export	NN
cord-295807-68sukdb1	931	66	as	as	IN
cord-295807-68sukdb1	931	67	an	an	DT
cord-295807-68sukdb1	931	68	anticancer	anticancer	JJ
cord-295807-68sukdb1	931	69	strategy	strategy	NN
cord-295807-68sukdb1	931	70	Manipulating	manipulate	VBG
cord-295807-68sukdb1	931	71	pH	ph	NN
cord-295807-68sukdb1	931	72	in	in	IN
cord-295807-68sukdb1	931	73	Cancer	Cancer	NNP
cord-295807-68sukdb1	931	74	Treatment	Treatment	NNP
cord-295807-68sukdb1	931	75	:	:	:
cord-295807-68sukdb1	932	1	Alkalizing	Alkalizing	NNP
cord-295807-68sukdb1	932	2	Drugs	Drugs	NNPS
cord-295807-68sukdb1	932	3	and	and	CC
cord-295807-68sukdb1	932	4	Alkaline	Alkaline	NNP
cord-295807-68sukdb1	932	5	Diet	Diet	NNP
cord-295807-68sukdb1	932	6	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	932	7	increases	increase	VBZ
cord-295807-68sukdb1	932	8	tumor	tumor	NN
cord-295807-68sukdb1	932	9	pH	ph	NN
cord-295807-68sukdb1	932	10	and	and	CC
cord-295807-68sukdb1	932	11	inhibits	inhibit	VBZ
cord-295807-68sukdb1	932	12	spontaneous	spontaneous	JJ
cord-295807-68sukdb1	932	13	metastases	metastasis	NNS
cord-295807-68sukdb1	932	14	Targeting	target	VBG
cord-295807-68sukdb1	932	15	the	the	DT
cord-295807-68sukdb1	932	16	Acidic	acidic	JJ
cord-295807-68sukdb1	932	17	Tumor	tumor	NN
cord-295807-68sukdb1	932	18	Microenvironment	Microenvironment	NNP
cord-295807-68sukdb1	932	19	:	:	:
cord-295807-68sukdb1	932	20	Unexpected	unexpected	JJ
cord-295807-68sukdb1	932	21	Pro	pro	JJ
cord-295807-68sukdb1	932	22	-	-	JJ
cord-295807-68sukdb1	932	23	Neoplastic	neoplastic	JJ
cord-295807-68sukdb1	932	24	Effects	effect	NNS
cord-295807-68sukdb1	932	25	of	of	IN
cord-295807-68sukdb1	932	26	Oral	oral	JJ
cord-295807-68sukdb1	932	27	NaHCO3	nahco3	NN
cord-295807-68sukdb1	932	28	Therapy	Therapy	NNP
cord-295807-68sukdb1	932	29	in	in	IN
cord-295807-68sukdb1	932	30	Murine	Murine	NNP
cord-295807-68sukdb1	932	31	Breast	Breast	NNP
cord-295807-68sukdb1	932	32	Tissue	Tissue	NNP
cord-295807-68sukdb1	932	33	A	a	DT
cord-295807-68sukdb1	932	34	nonrandomized	nonrandomized	JJ
cord-295807-68sukdb1	932	35	cohort	cohort	NN
cord-295807-68sukdb1	932	36	and	and	CC
cord-295807-68sukdb1	932	37	a	a	DT
cord-295807-68sukdb1	932	38	randomized	randomized	JJ
cord-295807-68sukdb1	932	39	study	study	NN
cord-295807-68sukdb1	932	40	of	of	IN
cord-295807-68sukdb1	932	41	local	local	JJ
cord-295807-68sukdb1	932	42	control	control	NN
cord-295807-68sukdb1	932	43	of	of	IN
cord-295807-68sukdb1	932	44	large	large	JJ
cord-295807-68sukdb1	932	45	hepatocarcinoma	hepatocarcinoma	NN
cord-295807-68sukdb1	932	46	by	by	IN
cord-295807-68sukdb1	932	47	targeting	target	VBG
cord-295807-68sukdb1	932	48	intratumoral	intratumoral	JJ
cord-295807-68sukdb1	932	49	lactic	lactic	NN
cord-295807-68sukdb1	932	50	acidosis	acidosis	NN
cord-295807-68sukdb1	932	51	Pros	pro	NNS
cord-295807-68sukdb1	932	52	and	and	CC
cord-295807-68sukdb1	932	53	Cons	con	NNS
cord-295807-68sukdb1	932	54	of	of	IN
cord-295807-68sukdb1	932	55	Dietary	dietary	JJ
cord-295807-68sukdb1	932	56	Strategies	strategy	NNS
cord-295807-68sukdb1	933	1	Popular	popular	JJ
cord-295807-68sukdb1	933	2	Among	among	IN
cord-295807-68sukdb1	933	3	Cancer	Cancer	NNP
cord-295807-68sukdb1	933	4	Patients	patient	NNS
cord-295807-68sukdb1	934	1	Irinotecan	Irinotecan	NNP
cord-295807-68sukdb1	934	2	-	-	HYPH
cord-295807-68sukdb1	934	3	induced	induce	VBN
cord-295807-68sukdb1	934	4	neutropenia	neutropenia	NN
cord-295807-68sukdb1	934	5	is	be	VBZ
cord-295807-68sukdb1	934	6	reduced	reduce	VBN
cord-295807-68sukdb1	934	7	by	by	IN
cord-295807-68sukdb1	934	8	oral	oral	JJ
cord-295807-68sukdb1	934	9	alkalization	alkalization	NN
cord-295807-68sukdb1	934	10	drugs	drug	NNS
cord-295807-68sukdb1	934	11	:	:	:
cord-295807-68sukdb1	934	12	analysis	analysis	NN
cord-295807-68sukdb1	934	13	using	use	VBG
cord-295807-68sukdb1	934	14	retrospective	retrospective	JJ
cord-295807-68sukdb1	934	15	chart	chart	NN
cord-295807-68sukdb1	934	16	reviews	review	NNS
cord-295807-68sukdb1	934	17	and	and	CC
cord-295807-68sukdb1	934	18	the	the	DT
cord-295807-68sukdb1	934	19	spontaneous	spontaneous	JJ
cord-295807-68sukdb1	934	20	reporting	reporting	NN
cord-295807-68sukdb1	934	21	database	database	NN
cord-295807-68sukdb1	934	22	Martínez	Martínez	NNP
cord-295807-68sukdb1	934	23	-	-	HYPH
cord-295807-68sukdb1	934	24	Climent	Climent	NNP
cord-295807-68sukdb1	934	25	,	,	,
cord-295807-68sukdb1	934	26	Targeting	target	VBG
cord-295807-68sukdb1	934	27	the	the	DT
cord-295807-68sukdb1	934	28	anion	anion	NN
cord-295807-68sukdb1	934	29	exchanger	exchanger	NN
cord-295807-68sukdb1	934	30	2	2	CD
cord-295807-68sukdb1	934	31	with	with	IN
cord-295807-68sukdb1	934	32	specific	specific	JJ
cord-295807-68sukdb1	934	33	peptides	peptide	NNS
cord-295807-68sukdb1	934	34	as	as	IN
cord-295807-68sukdb1	934	35	a	a	DT
cord-295807-68sukdb1	934	36	new	new	JJ
cord-295807-68sukdb1	934	37	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	934	38	approach	approach	NN
cord-295807-68sukdb1	934	39	in	in	IN
cord-295807-68sukdb1	934	40	B	b	NN
cord-295807-68sukdb1	934	41	lymphoid	lymphoid	JJ
cord-295807-68sukdb1	934	42	neoplasms	neoplasm	NNS
cord-295807-68sukdb1	934	43	Intestinal	intestinal	VBP
cord-295807-68sukdb1	934	44	luminal	luminal	JJ
cord-295807-68sukdb1	934	45	pH	ph	NN
cord-295807-68sukdb1	934	46	in	in	IN
cord-295807-68sukdb1	934	47	inflammatory	inflammatory	JJ
cord-295807-68sukdb1	934	48	bowel	bowel	NN
cord-295807-68sukdb1	934	49	disease	disease	NN
cord-295807-68sukdb1	934	50	:	:	:
cord-295807-68sukdb1	934	51	possible	possible	JJ
cord-295807-68sukdb1	934	52	determinants	determinant	NNS
cord-295807-68sukdb1	934	53	and	and	CC
cord-295807-68sukdb1	934	54	implications	implication	NNS
cord-295807-68sukdb1	934	55	for	for	IN
cord-295807-68sukdb1	934	56	therapy	therapy	NN
cord-295807-68sukdb1	934	57	with	with	IN
cord-295807-68sukdb1	934	58	aminosalicylates	aminosalicylate	NNS
cord-295807-68sukdb1	934	59	and	and	CC
cord-295807-68sukdb1	934	60	other	other	JJ
cord-295807-68sukdb1	934	61	drugs	drug	NNS
cord-295807-68sukdb1	934	62	Measurement	Measurement	NNP
cord-295807-68sukdb1	934	63	of	of	IN
cord-295807-68sukdb1	934	64	gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	934	65	pH	ph	NN
cord-295807-68sukdb1	934	66	profiles	profile	NNS
cord-295807-68sukdb1	934	67	in	in	IN
cord-295807-68sukdb1	934	68	normal	normal	JJ
cord-295807-68sukdb1	934	69	ambulant	ambulant	JJ
cord-295807-68sukdb1	934	70	human	human	JJ
cord-295807-68sukdb1	934	71	subjects	subject	NNS
cord-295807-68sukdb1	934	72	Advances	advance	VBZ
cord-295807-68sukdb1	934	73	in	in	IN
cord-295807-68sukdb1	934	74	Oral	oral	JJ
cord-295807-68sukdb1	934	75	Drug	Drug	NNP
cord-295807-68sukdb1	934	76	Delivery	Delivery	NNP
cord-295807-68sukdb1	934	77	for	for	IN
cord-295807-68sukdb1	934	78	Regional	Regional	NNP
cord-295807-68sukdb1	934	79	Targeting	Targeting	NNP
cord-295807-68sukdb1	934	80	in	in	IN
cord-295807-68sukdb1	934	81	the	the	DT
cord-295807-68sukdb1	934	82	Gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	934	83	Tract	tract	NN
cord-295807-68sukdb1	934	84	-Influence	-influence	NN
cord-295807-68sukdb1	934	85	of	of	IN
cord-295807-68sukdb1	934	86	Physiological	physiological	JJ
cord-295807-68sukdb1	934	87	,	,	,
cord-295807-68sukdb1	934	88	Pathophysiological	Pathophysiological	NNP
cord-295807-68sukdb1	934	89	and	and	CC
cord-295807-68sukdb1	934	90	Pharmaceutical	Pharmaceutical	NNP
cord-295807-68sukdb1	934	91	Factors	Factors	NNP
cord-295807-68sukdb1	934	92	Impact	Impact	NNP
cord-295807-68sukdb1	934	93	of	of	IN
cord-295807-68sukdb1	934	94	gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	934	95	disease	disease	NN
cord-295807-68sukdb1	934	96	states	state	NNS
cord-295807-68sukdb1	934	97	on	on	IN
cord-295807-68sukdb1	934	98	oral	oral	JJ
cord-295807-68sukdb1	934	99	drug	drug	NN
cord-295807-68sukdb1	934	100	absorption	absorption	NN
cord-295807-68sukdb1	934	101	-implications	-implication	NNS
cord-295807-68sukdb1	934	102	for	for	IN
cord-295807-68sukdb1	934	103	formulation	formulation	NN
cord-295807-68sukdb1	934	104	design	design	NN
cord-295807-68sukdb1	935	1	-a	-a	:
cord-295807-68sukdb1	935	2	PEARRL	PEARRL	NNP
cord-295807-68sukdb1	935	3	review	review	NN
cord-295807-68sukdb1	935	4	Food	food	NN
cord-295807-68sukdb1	935	5	,	,	,
cord-295807-68sukdb1	935	6	gastrointestinal	gastrointestinal	JJ
cord-295807-68sukdb1	935	7	pH	ph	NN
cord-295807-68sukdb1	935	8	,	,	,
cord-295807-68sukdb1	935	9	and	and	CC
cord-295807-68sukdb1	935	10	models	model	NNS
cord-295807-68sukdb1	935	11	of	of	IN
cord-295807-68sukdb1	935	12	oral	oral	JJ
cord-295807-68sukdb1	935	13	drug	drug	NN
cord-295807-68sukdb1	935	14	absorption	absorption	NN
cord-295807-68sukdb1	935	15	Literature	Literature	NNP
cord-295807-68sukdb1	935	16	Review	Review	NNP
cord-295807-68sukdb1	935	17	of	of	IN
cord-295807-68sukdb1	935	18	Gastrointestinal	Gastrointestinal	NNP
cord-295807-68sukdb1	935	19	Physiology	Physiology	NNP
cord-295807-68sukdb1	935	20	in	in	IN
cord-295807-68sukdb1	935	21	the	the	DT
cord-295807-68sukdb1	935	22	Elderly	Elderly	NNP
cord-295807-68sukdb1	935	23	Prediction	Prediction	NNP
cord-295807-68sukdb1	935	24	of	of	IN
cord-295807-68sukdb1	935	25	pH	pH	NNP
cord-295807-68sukdb1	935	26	-	-	HYPH
cord-295807-68sukdb1	935	27	Dependent	Dependent	NNP
cord-295807-68sukdb1	935	28	Drug	Drug	NNP
cord-295807-68sukdb1	935	29	-	-	HYPH
cord-295807-68sukdb1	935	30	Drug	Drug	NNP
cord-295807-68sukdb1	935	31	Interactions	Interactions	NNPS
cord-295807-68sukdb1	935	32	for	for	IN
cord-295807-68sukdb1	935	33	Basic	basic	JJ
cord-295807-68sukdb1	935	34	Drugs	drug	NNS
cord-295807-68sukdb1	935	35	Using	use	VBG
cord-295807-68sukdb1	935	36	Physiologically	physiologically	RB
cord-295807-68sukdb1	935	37	Based	Based	NNP
cord-295807-68sukdb1	935	38	Biopharmaceutics	Biopharmaceutics	NNP
cord-295807-68sukdb1	935	39	Modeling	Modeling	NNP
cord-295807-68sukdb1	935	40	:	:	:
cord-295807-68sukdb1	936	1	Industry	Industry	NNP
cord-295807-68sukdb1	936	2	Case	Case	NNP
cord-295807-68sukdb1	936	3	Studies	Studies	NNPS
cord-295807-68sukdb1	936	4	Study	Study	NNP
cord-295807-68sukdb1	936	5	of	of	IN
cord-295807-68sukdb1	936	6	pH	ph	JJ
cord-295807-68sukdb1	936	7	-	-	HYPH
cord-295807-68sukdb1	936	8	dependent	dependent	JJ
cord-295807-68sukdb1	936	9	drugs	drug	NNS
cord-295807-68sukdb1	936	10	solubility	solubility	NN
cord-295807-68sukdb1	936	11	in	in	IN
cord-295807-68sukdb1	936	12	water	water	NN
cord-295807-68sukdb1	936	13	Acidic	acidic	JJ
cord-295807-68sukdb1	936	14	and	and	CC
cord-295807-68sukdb1	936	15	Basic	basic	JJ
cord-295807-68sukdb1	936	16	Drugs	Drugs	NNPS
cord-295807-68sukdb1	936	17	in	in	IN
cord-295807-68sukdb1	936	18	Medicinal	Medicinal	NNP
cord-295807-68sukdb1	936	19	Chemistry	Chemistry	NNP
cord-295807-68sukdb1	936	20	:	:	:
cord-295807-68sukdb1	937	1	A	a	DT
cord-295807-68sukdb1	937	2	Perspective	perspective	NN
cord-295807-68sukdb1	937	3	Drug	drug	NN
cord-295807-68sukdb1	937	4	Solubility	solubility	NN
cord-295807-68sukdb1	937	5	:	:	:
cord-295807-68sukdb1	937	6	Importance	importance	NN
cord-295807-68sukdb1	937	7	and	and	CC
cord-295807-68sukdb1	937	8	Enhancement	Enhancement	NNP
cord-295807-68sukdb1	937	9	Techniques	Techniques	NNPS
cord-295807-68sukdb1	937	10	,	,	,
cord-295807-68sukdb1	937	11	ISRN	ISRN	NNP
cord-295807-68sukdb1	937	12	Pharm	Pharm	NNP
cord-295807-68sukdb1	937	13	Physicochemical	Physicochemical	NNP
cord-295807-68sukdb1	937	14	Properties	Properties	NNP
cord-295807-68sukdb1	937	15	,	,	,
cord-295807-68sukdb1	937	16	Formulation	Formulation	NNP
cord-295807-68sukdb1	937	17	,	,	,
cord-295807-68sukdb1	937	18	and	and	CC
cord-295807-68sukdb1	937	19	Drug	Drug	NNP
cord-295807-68sukdb1	937	20	Delivery	Delivery	NNP
cord-295807-68sukdb1	937	21	A	a	DT
cord-295807-68sukdb1	937	22	quantitative	quantitative	JJ
cord-295807-68sukdb1	937	23	assessment	assessment	NN
cord-295807-68sukdb1	937	24	of	of	IN
cord-295807-68sukdb1	937	25	hERG	herg	NN
cord-295807-68sukdb1	937	26	liability	liability	NN
cord-295807-68sukdb1	937	27	as	as	IN
cord-295807-68sukdb1	937	28	a	a	DT
cord-295807-68sukdb1	937	29	function	function	NN
cord-295807-68sukdb1	937	30	of	of	IN
cord-295807-68sukdb1	937	31	lipophilicity	lipophilicity	NN
cord-295807-68sukdb1	938	1	Some	some	DT
cord-295807-68sukdb1	938	2	aspects	aspect	NNS
cord-295807-68sukdb1	938	3	of	of	IN
cord-295807-68sukdb1	938	4	cell	cell	NN
cord-295807-68sukdb1	938	5	permeability	permeability	NN
cord-295807-68sukdb1	938	6	to	to	IN
cord-295807-68sukdb1	938	7	weak	weak	JJ
cord-295807-68sukdb1	938	8	electrolytes	electrolyte	NNS
cord-295807-68sukdb1	939	1	The	the	DT
cord-295807-68sukdb1	939	2	gastric	gastric	JJ
cord-295807-68sukdb1	939	3	secretion	secretion	NN
cord-295807-68sukdb1	939	4	of	of	IN
cord-295807-68sukdb1	939	5	drugs	drug	NNS
cord-295807-68sukdb1	939	6	:	:	:
cord-295807-68sukdb1	939	7	a	a	DT
cord-295807-68sukdb1	939	8	pH	ph	NN
cord-295807-68sukdb1	939	9	partition	partition	NN
cord-295807-68sukdb1	939	10	hypothesis	hypothesis	NN
cord-295807-68sukdb1	939	11	Surface	Surface	NNP
cord-295807-68sukdb1	939	12	area	area	NN
cord-295807-68sukdb1	939	13	of	of	IN
cord-295807-68sukdb1	939	14	the	the	DT
cord-295807-68sukdb1	939	15	digestive	digestive	JJ
cord-295807-68sukdb1	939	16	tract	tract	NN
cord-295807-68sukdb1	939	17	-revisited	-revisited	JJ
cord-295807-68sukdb1	939	18	Tight	tight	JJ
cord-295807-68sukdb1	939	19	junction	junction	NN
cord-295807-68sukdb1	939	20	modulation	modulation	NN
cord-295807-68sukdb1	939	21	and	and	CC
cord-295807-68sukdb1	939	22	its	-PRON-	PRP$
cord-295807-68sukdb1	939	23	relationship	relationship	NN
cord-295807-68sukdb1	939	24	to	to	IN
cord-295807-68sukdb1	939	25	drug	drug	NN
cord-295807-68sukdb1	939	26	delivery	delivery	NN
cord-295807-68sukdb1	939	27	Polyspecific	Polyspecific	NNP
cord-295807-68sukdb1	939	28	Organic	Organic	NNP
cord-295807-68sukdb1	939	29	Cation	Cation	NNP
cord-295807-68sukdb1	939	30	Transporters	Transporters	NNPS
cord-295807-68sukdb1	939	31	and	and	CC
cord-295807-68sukdb1	939	32	their	-PRON-	PRP$
cord-295807-68sukdb1	939	33	Impact	Impact	NNP
cord-295807-68sukdb1	939	34	on	on	IN
cord-295807-68sukdb1	939	35	Drug	Drug	NNP
cord-295807-68sukdb1	939	36	Intracellular	Intracellular	NNP
cord-295807-68sukdb1	939	37	Levels	Levels	NNPS
cord-295807-68sukdb1	939	38	and	and	CC
cord-295807-68sukdb1	939	39	Pharmacodynamics	Pharmacodynamics	NNPS
cord-295807-68sukdb1	940	1	The	the	DT
cord-295807-68sukdb1	940	2	human	human	JJ
cord-295807-68sukdb1	940	3	organic	organic	JJ
cord-295807-68sukdb1	940	4	cation	cation	NN
cord-295807-68sukdb1	940	5	transporter	transporter	NN
cord-295807-68sukdb1	940	6	OCT1	OCT1	NNP
cord-295807-68sukdb1	940	7	mediates	mediate	VBZ
cord-295807-68sukdb1	940	8	high	high	JJ
cord-295807-68sukdb1	940	9	affinity	affinity	NN
cord-295807-68sukdb1	940	10	uptake	uptake	NN
cord-295807-68sukdb1	940	11	of	of	IN
cord-295807-68sukdb1	940	12	the	the	DT
cord-295807-68sukdb1	940	13	anticancer	anticancer	JJ
cord-295807-68sukdb1	940	14	drug	drug	NN
cord-295807-68sukdb1	940	15	daunorubicin	daunorubicin	NNS
cord-295807-68sukdb1	941	1	The	the	DT
cord-295807-68sukdb1	941	2	Organic	Organic	NNP
cord-295807-68sukdb1	941	3	Anion	Anion	NNP
cord-295807-68sukdb1	941	4	Transporter	Transporter	NNP
cord-295807-68sukdb1	941	5	(	(	-LRB-
cord-295807-68sukdb1	941	6	OAT	OAT	NNP
cord-295807-68sukdb1	941	7	)	)	-RRB-
cord-295807-68sukdb1	941	8	Family	family	NN
cord-295807-68sukdb1	941	9	:	:	:
cord-295807-68sukdb1	942	1	A	a	DT
cord-295807-68sukdb1	942	2	Systems	Systems	NNPS
cord-295807-68sukdb1	942	3	Biology	Biology	NNP
cord-295807-68sukdb1	942	4	Perspective	perspective	NN
cord-295807-68sukdb1	943	1	The	the	DT
cord-295807-68sukdb1	943	2	P	P	NNP
cord-295807-68sukdb1	943	3	-	-	HYPH
cord-295807-68sukdb1	943	4	Glycoprotein	Glycoprotein	NNP
cord-295807-68sukdb1	943	5	Transport	Transport	NNP
cord-295807-68sukdb1	943	6	System	System	NNP
cord-295807-68sukdb1	943	7	and	and	CC
cord-295807-68sukdb1	943	8	Cardiovascular	cardiovascular	JJ
cord-295807-68sukdb1	943	9	Drugs	drug	NNS
cord-295807-68sukdb1	943	10	Drugs	drug	NNS
cord-295807-68sukdb1	943	11	as	as	IN
cord-295807-68sukdb1	943	12	P	p	NN
cord-295807-68sukdb1	943	13	-	-	HYPH
cord-295807-68sukdb1	943	14	glycoprotein	glycoprotein	NN
cord-295807-68sukdb1	943	15	substrates	substrate	NNS
cord-295807-68sukdb1	943	16	,	,	,
cord-295807-68sukdb1	943	17	inhibitors	inhibitor	NNS
cord-295807-68sukdb1	943	18	,	,	,
cord-295807-68sukdb1	943	19	and	and	CC
cord-295807-68sukdb1	943	20	inducers	inducer	NNS
cord-295807-68sukdb1	943	21	Impaired	impair	VBD
cord-295807-68sukdb1	943	22	Drug	Drug	NNP
cord-295807-68sukdb1	943	23	Absorption	Absorption	NNP
cord-295807-68sukdb1	944	1	Due	due	IN
cord-295807-68sukdb1	944	2	to	to	IN
cord-295807-68sukdb1	944	3	High	high	JJ
cord-295807-68sukdb1	944	4	Stomach	stomach	NN
cord-295807-68sukdb1	944	5	pH	ph	NN
cord-295807-68sukdb1	944	6	:	:	:
cord-295807-68sukdb1	945	1	A	a	DT
cord-295807-68sukdb1	945	2	Review	Review	NNP
cord-295807-68sukdb1	945	3	of	of	IN
cord-295807-68sukdb1	945	4	Strategies	Strategies	NNPS
cord-295807-68sukdb1	945	5	for	for	IN
cord-295807-68sukdb1	945	6	Mitigation	Mitigation	NNP
cord-295807-68sukdb1	945	7	of	of	IN
cord-295807-68sukdb1	945	8	Such	such	JJ
cord-295807-68sukdb1	945	9	Effect	effect	NN
cord-295807-68sukdb1	946	1	To	to	TO
cord-295807-68sukdb1	946	2	Enable	enable	VB
cord-295807-68sukdb1	946	3	Pharmaceutical	Pharmaceutical	NNP
cord-295807-68sukdb1	946	4	Product	product	NN
cord-295807-68sukdb1	946	5	Development	Development	NNP
cord-295807-68sukdb1	946	6	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	946	7	Alters	alter	VBZ
cord-295807-68sukdb1	946	8	Bacterial	bacterial	JJ
cord-295807-68sukdb1	946	9	Susceptibility	susceptibility	NN
cord-295807-68sukdb1	946	10	to	to	IN
cord-295807-68sukdb1	946	11	Antibiotics	antibiotic	NNS
cord-295807-68sukdb1	946	12	by	by	IN
cord-295807-68sukdb1	946	13	Targeting	target	VBG
cord-295807-68sukdb1	946	14	the	the	DT
cord-295807-68sukdb1	946	15	Proton	Proton	NNP
cord-295807-68sukdb1	946	16	Motive	Motive	NNP
cord-295807-68sukdb1	946	17	Force	Force	NNP
cord-295807-68sukdb1	946	18	Ionotropically	Ionotropically	NNP
cord-295807-68sukdb1	946	19	cross	cross	VB
cord-295807-68sukdb1	946	20	-	-	JJ
cord-295807-68sukdb1	946	21	linked	link	VBN
cord-295807-68sukdb1	946	22	pH	ph	NN
cord-295807-68sukdb1	946	23	-	-	HYPH
cord-295807-68sukdb1	946	24	sensitive	sensitive	JJ
cord-295807-68sukdb1	946	25	IPN	IPN	NNP
cord-295807-68sukdb1	946	26	hydrogel	hydrogel	NN
cord-295807-68sukdb1	946	27	matrices	matrix	NNS
cord-295807-68sukdb1	946	28	as	as	IN
cord-295807-68sukdb1	946	29	potential	potential	JJ
cord-295807-68sukdb1	946	30	carriers	carrier	NNS
cord-295807-68sukdb1	946	31	for	for	IN
cord-295807-68sukdb1	946	32	intestine	intestine	NN
cord-295807-68sukdb1	946	33	-	-	HYPH
cord-295807-68sukdb1	946	34	specific	specific	JJ
cord-295807-68sukdb1	946	35	oral	oral	JJ
cord-295807-68sukdb1	946	36	delivery	delivery	NN
cord-295807-68sukdb1	946	37	of	of	IN
cord-295807-68sukdb1	946	38	protein	protein	NN
cord-295807-68sukdb1	946	39	drugs	drug	NNS
cord-295807-68sukdb1	946	40	Peppas	Peppas	NNP
cord-295807-68sukdb1	946	41	,	,	,
cord-295807-68sukdb1	946	42	pH	ph	NN
cord-295807-68sukdb1	946	43	-	-	NN
cord-295807-68sukdb1	946	44	responsive	responsive	JJ
cord-295807-68sukdb1	946	45	and	and	CC
cord-295807-68sukdb1	946	46	enzymatically	enzymatically	RB
cord-295807-68sukdb1	946	47	-	-	HYPH
cord-295807-68sukdb1	946	48	responsive	responsive	JJ
cord-295807-68sukdb1	946	49	hydrogel	hydrogel	NN
cord-295807-68sukdb1	946	50	microparticles	microparticle	NNS
cord-295807-68sukdb1	946	51	for	for	IN
cord-295807-68sukdb1	946	52	the	the	DT
cord-295807-68sukdb1	946	53	oral	oral	JJ
cord-295807-68sukdb1	946	54	delivery	delivery	NN
cord-295807-68sukdb1	946	55	of	of	IN
cord-295807-68sukdb1	946	56	therapeutic	therapeutic	JJ
cord-295807-68sukdb1	946	57	proteins	protein	NNS
cord-295807-68sukdb1	946	58	:	:	:
cord-295807-68sukdb1	946	59	Effects	effect	NNS
cord-295807-68sukdb1	946	60	of	of	IN
cord-295807-68sukdb1	946	61	protein	protein	NN
cord-295807-68sukdb1	946	62	size	size	NN
cord-295807-68sukdb1	946	63	,	,	,
cord-295807-68sukdb1	946	64	crosslinking	crosslinke	VBG
cord-295807-68sukdb1	946	65	density	density	NN
cord-295807-68sukdb1	946	66	,	,	,
cord-295807-68sukdb1	946	67	and	and	CC
cord-295807-68sukdb1	946	68	hydrogel	hydrogel	NN
cord-295807-68sukdb1	946	69	degradation	degradation	NN
cord-295807-68sukdb1	946	70	on	on	IN
cord-295807-68sukdb1	946	71	protein	protein	NN
cord-295807-68sukdb1	946	72	delivery	delivery	NN
cord-295807-68sukdb1	946	73	Nanotechnology	Nanotechnology	NNP
cord-295807-68sukdb1	946	74	for	for	IN
cord-295807-68sukdb1	946	75	protein	protein	NN
cord-295807-68sukdb1	946	76	delivery	delivery	NN
cord-295807-68sukdb1	946	77	:	:	:
cord-295807-68sukdb1	946	78	Overview	overview	NN
cord-295807-68sukdb1	946	79	and	and	CC
cord-295807-68sukdb1	946	80	perspectives	perspective	VBZ
cord-295807-68sukdb1	946	81	Eudragit	Eudragit	NNP
cord-295807-68sukdb1	946	82	:	:	:
cord-295807-68sukdb1	946	83	a	a	DT
cord-295807-68sukdb1	946	84	technology	technology	NN
cord-295807-68sukdb1	946	85	evaluation	evaluation	NN
cord-295807-68sukdb1	946	86	Preparation	preparation	NN
cord-295807-68sukdb1	946	87	of	of	IN
cord-295807-68sukdb1	946	88	Layer	Layer	NNP
cord-295807-68sukdb1	946	89	-	-	HYPH
cord-295807-68sukdb1	946	90	by	by	IN
cord-295807-68sukdb1	946	91	-	-	HYPH
cord-295807-68sukdb1	946	92	layer	layer	NN
cord-295807-68sukdb1	946	93	Thin	Thin	NNP
cord-295807-68sukdb1	946	94	Films	Films	NNPS
cord-295807-68sukdb1	946	95	Containing	contain	VBG
cord-295807-68sukdb1	946	96	Insulin	Insulin	NNP
cord-295807-68sukdb1	946	97	and	and	CC
cord-295807-68sukdb1	946	98	its	-PRON-	PRP$
cord-295807-68sukdb1	946	99	pH	ph	JJ
cord-295807-68sukdb1	946	100	-	-	HYPH
cord-295807-68sukdb1	946	101	Sensitive	sensitive	JJ
cord-295807-68sukdb1	946	102	Decomposition	decomposition	NN
cord-295807-68sukdb1	946	103	Oral	oral	JJ
cord-295807-68sukdb1	946	104	delivery	delivery	NN
cord-295807-68sukdb1	946	105	of	of	IN
cord-295807-68sukdb1	946	106	insulin	insulin	NN
cord-295807-68sukdb1	946	107	using	use	VBG
cord-295807-68sukdb1	946	108	pH	pH	NNP
cord-295807-68sukdb1	946	109	-	-	HYPH
cord-295807-68sukdb1	946	110	responsive	responsive	JJ
cord-295807-68sukdb1	946	111	complexation	complexation	NN
cord-295807-68sukdb1	946	112	gels	gel	VBZ
cord-295807-68sukdb1	946	113	Fundaments	Fundaments	NNP
cord-295807-68sukdb1	946	114	of	of	IN
cord-295807-68sukdb1	946	115	Toxicology	Toxicology	NNP
cord-295807-68sukdb1	946	116	-	-	HYPH
cord-295807-68sukdb1	946	117	Approach	Approach	NNP
cord-295807-68sukdb1	946	118	to	to	IN
cord-295807-68sukdb1	946	119	the	the	DT
cord-295807-68sukdb1	946	120	Poisoned	Poisoned	NNP
cord-295807-68sukdb1	946	121	Patient	Patient	NNP
cord-295807-68sukdb1	947	1	The	the	DT
cord-295807-68sukdb1	947	2	Role	role	NN
cord-295807-68sukdb1	947	3	of	of	IN
cord-295807-68sukdb1	947	4	Sodium	Sodium	NNP
cord-295807-68sukdb1	947	5	Bicarbonate	Bicarbonate	NNP
cord-295807-68sukdb1	947	6	in	in	IN
cord-295807-68sukdb1	947	7	the	the	DT
cord-295807-68sukdb1	947	8	Management	Management	NNP
cord-295807-68sukdb1	947	9	of	of	IN
cord-295807-68sukdb1	947	10	Some	some	DT
cord-295807-68sukdb1	947	11	Toxic	Toxic	NNP
cord-295807-68sukdb1	947	12	Ingestions	Ingestions	NNP
cord-295807-68sukdb1	947	13	Acid	acid	NN
cord-295807-68sukdb1	947	14	-	-	HYPH
cord-295807-68sukdb1	947	15	alkaline	alkaline	JJ
cord-295807-68sukdb1	947	16	balance	balance	NN
cord-295807-68sukdb1	947	17	:	:	:
cord-295807-68sukdb1	947	18	role	role	NN
cord-295807-68sukdb1	947	19	in	in	IN
cord-295807-68sukdb1	947	20	chronic	chronic	JJ
cord-295807-68sukdb1	947	21	disease	disease	NN
cord-295807-68sukdb1	947	22	and	and	CC
cord-295807-68sukdb1	947	23	detoxification	detoxification	NN
cord-295807-68sukdb1	947	24	.	.	.
cord-295807-68sukdb1	947	25	,	,	,
cord-295807-68sukdb1	947	26	Alternative	Alternative	NNP
cord-295807-68sukdb1	947	27	Therapies	Therapies	NNPS
cord-295807-68sukdb1	947	28	in	in	IN
cord-295807-68sukdb1	947	29	Health	Health	NNP
cord-295807-68sukdb1	947	30	and	and	CC
cord-295807-68sukdb1	947	31	Medicine	Medicine	NNP
cord-295807-68sukdb1	947	32	Relationship	Relationship	NNP
cord-295807-68sukdb1	947	33	Between	between	IN
cord-295807-68sukdb1	947	34	the	the	DT
cord-295807-68sukdb1	947	35	Urinary	urinary	JJ
cord-295807-68sukdb1	947	36	Excretion	Excretion	NNP
cord-295807-68sukdb1	947	37	Mechanisms	Mechanisms	NNPS
cord-295807-68sukdb1	947	38	of	of	IN
cord-295807-68sukdb1	947	39	Drugs	drug	NNS
cord-295807-68sukdb1	947	40	and	and	CC
cord-295807-68sukdb1	947	41	Their	-PRON-	PRP$
cord-295807-68sukdb1	947	42	Physicochemical	Physicochemical	NNP
cord-295807-68sukdb1	947	43	Properties	Properties	NNPS
cord-295807-68sukdb1	947	44	Gastro	Gastro	NNP
cord-295807-68sukdb1	947	45	-	-	HYPH
cord-295807-68sukdb1	947	46	floating	float	VBG
cord-295807-68sukdb1	947	47	matrices	matrix	NNS
cord-295807-68sukdb1	947	48	designed	design	VBN
cord-295807-68sukdb1	947	49	for	for	IN
cord-295807-68sukdb1	947	50	simultaneous	simultaneous	JJ
cord-295807-68sukdb1	947	51	improvement	improvement	NN
cord-295807-68sukdb1	947	52	of	of	IN
cord-295807-68sukdb1	947	53	floating	float	VBG
cord-295807-68sukdb1	947	54	and	and	CC
cord-295807-68sukdb1	947	55	drug	drug	NN
cord-295807-68sukdb1	947	56	release	release	NN
cord-295807-68sukdb1	947	57	capabilities	capability	NNS
cord-295807-68sukdb1	947	58	:	:	:
cord-295807-68sukdb1	947	59	an	an	DT
cord-295807-68sukdb1	947	60	in	in	FW
cord-295807-68sukdb1	947	61	vitro	vitro	FW
cord-295807-68sukdb1	947	62	case	case	NN
cord-295807-68sukdb1	947	63	study	study	NN
cord-295807-68sukdb1	947	64	of	of	IN
cord-295807-68sukdb1	947	65	matrices	matrix	NNS
cord-295807-68sukdb1	947	66	loaded	load	VBN
cord-295807-68sukdb1	947	67	with	with	IN
cord-295807-68sukdb1	947	68	ciprofloxacin	ciprofloxacin	NN
cord-295807-68sukdb1	947	69	hydrochloride	hydrochloride	NN
cord-295807-68sukdb1	947	70	Environmental	Environmental	NNP
cord-295807-68sukdb1	947	71	pH	ph	NN
cord-295807-68sukdb1	947	72	-	-	HYPH
cord-295807-68sukdb1	947	73	sensitive	sensitive	JJ
cord-295807-68sukdb1	947	74	polymeric	polymeric	JJ
cord-295807-68sukdb1	947	75	micelles	micelle	NNS
cord-295807-68sukdb1	947	76	for	for	IN
cord-295807-68sukdb1	947	77	cancer	cancer	NN
cord-295807-68sukdb1	947	78	diagnosis	diagnosis	NN
cord-295807-68sukdb1	947	79	and	and	CC
cord-295807-68sukdb1	947	80	targeted	target	VBN
cord-295807-68sukdb1	947	81	therapy	therapy	NN
cord-295807-68sukdb1	948	1	A	a	DT
cord-295807-68sukdb1	948	2	drug	drug	NN
cord-295807-68sukdb1	948	3	screening	screening	NN
cord-295807-68sukdb1	948	4	assay	assay	NN
cord-295807-68sukdb1	948	5	on	on	IN
cord-295807-68sukdb1	948	6	cancer	cancer	NN
cord-295807-68sukdb1	948	7	cells	cell	NNS
cord-295807-68sukdb1	948	8	chronically	chronically	RB
cord-295807-68sukdb1	948	9	adapted	adapt	VBN
cord-295807-68sukdb1	948	10	to	to	IN
cord-295807-68sukdb1	948	11	acidosis	acidosis	NN