id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-351322-mdes28jg	Bauvois, Brigitte	Aminopeptidase‐N/CD13 (EC 3.4.11.2) inhibitors: Chemistry, biological evaluations, and therapeutic prospects	2005-10-07		.txt	text/plain	10028	678	40	235, 236 In addition to its very recently reported ability to inhibit APN in a non-competitive manner thus inducing a suppression of in vitro angiogenesis, 237 30 has been shown to induce a variety of biological effects: (i) a significant in vitro antibacterial activity against Staphylococcus aureus 226 and methicillin-resistant Staphylococcus aureus 235, 236, 238 which is assumed to be due to its ability to inhibit DNA gyrase, 238 (ii) a cytotoxicity against various human tumor cell lines, 229, [231] [232] [233] (iii) an increase in Ca 2þ release from the heavy fraction of skeletal muscle sarcoplasmic reticulum, 228 (iv) an inhibition of topoisomerase II, 239 Leucine aminopeptidase and farnesyl protein transferase, 229 , mycothiol-S-conjugate amidase, 240 chitinase, 231 histone deacetylase and DNA methyltransferase, 232 and DNA replication by targeting polymerase a-primase.	./cache/cord-351322-mdes28jg.txt	./txt/cord-351322-mdes28jg.txt