id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-346446-i7gpxcyo	Zhang, Jianguo	Biosynthetic Polymalic Acid as a Delivery Nanoplatform for Translational Cancer Medicine	2020-10-22		.txt	text/plain	6094	281	35	pullulan, the addition of exogenous carbonates augments CO 2 fixation and pyruvate carboxylation into oxaloacetate by pyruvate carboxylase in the cytoplasm, abolishing the intramitochondrial pathways for L-malate production and ensuing PMLA synthesis ( Figure 2 ) [23, 30] . At pH 7.4, the terminal α-carboxylic acid in the side chain is deprotonated and ionized; this would be repelled from the cell membrane, but, because of strong hydrophobic interactions, indole in the side chain can attract and intercalate into phospholipids, generating PMLA tritryptophan-lipid complexes and releasing binding energy to stabilize the structure. To increase the interaction between the biopolymer and the plasma membrane, methylation of carboxylic acid groups with different levels of diazomethane was used to generate a PMLA-Me x H 100−x copolymer (where x is the percentage of methyl units) [77, 78] . Analysis of the L-malate biosynthesis pathway involved in poly(beta-L-malic acid) production in Aureobasidium melanogenum GXZ-6 by addition of metabolic intermediates and inhibitors	./cache/cord-346446-i7gpxcyo.txt	./txt/cord-346446-i7gpxcyo.txt