id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-329228-yjvw2ee1	Shikata, N.	Multi-layered network structure of amino acid (AA) metabolism characterized by each essential AA-deficient condition	2006-10-13		.txt	text/plain	4395	230	55	The concentrations of free amino acids in plasma change coordinately and their profiles show distinctive features in various physiological conditions; however, their behavior can not always be explained by the conventional flow-based metabolic pathway network. In this study, we have revealed the interrelatedness of the plasma amino acids and inferred their network structure with threshold-test analysis and multilevel-digraph analysis methods using the plasma samples of rats which are fed diet deficient in single essential amino acid. Our strategy for the inference of interrelated amino acid networks can be summarized as follow: (1) Given data of fold-change in concentration of deficiency or over-consumption in one essential amino acid under the stationary state, the threshold-test analysis method is applied to infer binary relationships between target amino acids.	./cache/cord-329228-yjvw2ee1.txt	./txt/cord-329228-yjvw2ee1.txt