id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-319636-keo7gv70	Duarte, Carolina	Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration	2020-06-02		.txt	text/plain	8023	428	32	It was demonstrated that the activity of ACDase was significantly inhibited by Carmofur [55, 58] , LCL521 [19, 65, 69, 70] , Ceranib2 [24, [71] [72] [73] , N-oleocylethanolamine (NOE) [22, 57] , ARN14988 [74] , LCL204 [10, 64] , Monascus Purperus (MP) [18] , Hesperetin (Hst) [17] , Hesperetine-7-O-acetate (HTA) [17] , Silibinin [20] , Curcumin [23] , and Sanguinarine [21, 75] , leading to an increased accumulation of intracellular ceramide and apoptosis in various types of cancer cells, including glioblastoma; squamous cell carcinoma; acute myeloid leukemia; colorectal adenocarcinoma; and breast, prostate, lung, gastric, and kidney cancer. Ceramidases (acid, neutral, alkaline) are key enzymes that maintain the intracellular homeostasis of ceramide/SPH and are critical regulators of signals that tilt the balance between cell survival and death. Ceramidases (acid, neutral, alkaline) are key enzymes that maintain the intracellular homeostasis of ceramide/SPH and are critical regulators of signals that tilt the balance between cell survival and death.	./cache/cord-319636-keo7gv70.txt	./txt/cord-319636-keo7gv70.txt