id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-296794-ml2luc1t	Sollner, Johannes	Analysis and prediction of protective continuous B-cell epitopes on pathogen proteins	2008-01-07		.txt	text/plain	8006	387	41	This work assesses in how far correlation between antigenicity, variability, post-translational modifications and protectivity/functional relevance can be put to use in a predictive model without the availability of 3D data. Classification into presumably protective or non-protective epitopes is conducted using three independently determined parameters: predicted B-cell antigenicity, sequence variability and conservation of post-translational modification motifs. These results are relativated later in this work when using only potentially relevant domains of a protein antigen, indicating systematic problems of the way B-cell epitope prediction validation is usually conducted. Briefly, proteins were completely scored for antigenicity/protectivity but amino-acid scores in regions outside domains assumed to be surface exposed were set to 0 thus leading to a generic classification as non-protective. On this compilation protectivity prediction using PCA19 in combination with variability and modification likelihood performed significantly better after domain-accessibility filtering as measured by AROC values, while without filtering performance was comparable (although again slightly better) to antigenicity validation results on the Blythe et.al validation-set.	./cache/cord-296794-ml2luc1t.txt	./txt/cord-296794-ml2luc1t.txt