id author title date pages extension mime words sentences flesch summary cache txt cord-295807-68sukdb1 Quade, Bianca N. The therapeutic importance of acid-base balance 2020-10-09 .txt text/plain 20791 1128 42 Despite these specious claims, the therapeutic value of controlling acid-base balance is indisputable and is the basis of Food and Drug Administration-approved treatments for constipation, epilepsy, metabolic acidosis, and peptic ulcers. Although studies of the role of acid-base balance in health and disease have resulted in the generation of several FDA-approved pharmaceuticals such as contraceptive gels and gastric-acid suppressors, systematic reviews of random trials of the clinical effectiveness of NaHCO3 itself tend to be circumspect in their conclusions. For example: MAc can result from diet, chronic kidney disease, and diabetes (diabetic ketoacidosis) or can follow acute myocardial infarction (lactic acidosis), mutations in renal acid-base transporters (renal tubular acidosis, see section 4.9), intoxication with compounds (e.g., aspirin), and diarrhea (loss of HCO3 --rich secretions) [53] [54] [55] [56] [57] . ./cache/cord-295807-68sukdb1.txt ./txt/cord-295807-68sukdb1.txt