id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-024790-pkj2bjur	Çiçek, Serhat Sezai	Biological Activities of Two Major Copaiba Diterpenoids and Their Semi-synthetic Derivatives	2020-02-21		.txt	text/plain	5324	246	45	In order to find new biological activities and to eventually enhance the before observed effects, (−)-polyalthic acid (1) and kaurenoic acid (2), together with eight prepared semi-synthetic derivatives (1a–1c and 2a–2e) were evaluated for their cytotoxic, antibacterial and antifungal properties. Investigation of the antifungal activity, in contrast, showed that the carboxyl group is unnecessary for the effect against the dermatophytes Trichophyton rubrum and Cryptococcus neoformans, indicated by low micromolar IC(50) values for both (−)-polyalthic acid diethylamide (1a) as well as (−)-polyalthic acid methyl ester (1b). In our previous study, we reported strong inhibitory effects against the two clinically relevant bacterial strains methicillin-resistant Staphylococcus aureus (MRSA) and Enterococcus faecium for three diterpene acids, of which one was kaurenoic acid (2) (Pfeifer Barbosa et al. In the same study, antidermatophytic activity against two Trichopyhton species was detected for (−)-polyalthic acid (1), the major diterpenoid in the Copaifera reticulata oleoresin, along with weak [(−)-polyalthic acid, 1] to moderate (kaurenoic acid, 2) cytotoxic effects against six cancer cell lines.	./cache/cord-024790-pkj2bjur.txt	./txt/cord-024790-pkj2bjur.txt