id	author	title	date	pages	extension	mime	words	sentences	flesch	summary	cache	txt
cord-006452-mmdk2xom	Chen, Jing	Nucleic Acid-Based Therapeutics for Pulmonary Diseases	2018-10-18		.txt	text/plain	6605	361	38	Nucleic acid-based therapeutics present huge potential in the treatment of pulmonary diseases ranging from lung cancer to asthma and chronic pulmonary diseases, which are often fatal and widely prevalent. In this review, we provide a comprehensive overview of the nucleic acid application for pulmonary diseases, covering action mechanism of the nucleic acid drugs, the novel delivery systems, and the current formulation for the administration to lungs. To overcome these biological barriers, strategies like chemical modification, conjugation, vector encapsulation, and selection of administration route have been utilized to improve the delivery of nucleic acids to lungs. One direction for developing new drugs to treat asthma is to target central pathways to the pathogenesis of the disease, and nucleic acid-mediated therapies silencing the specific effector or the upstream regulator can be a potential approach. Nucleic acid drugs hold great promises as new classes of therapeutic agents for pulmonary diseases, and some candidates have entered into clinical trials (Table III) .	./cache/cord-006452-mmdk2xom.txt	./txt/cord-006452-mmdk2xom.txt