id	sid	tid	token	lemma	pos
cord-322966-o65fo853	1	1	key	key	JJ
cord-322966-o65fo853	1	2	:	:	:
cord-322966-o65fo853	1	3	cord-322966-o65fo853	cord-322966-o65fo853	JJ
cord-322966-o65fo853	1	4	authors	author	NNS
cord-322966-o65fo853	1	5	:	:	:
cord-322966-o65fo853	1	6	Arnold	Arnold	NNP
cord-322966-o65fo853	1	7	,	,	,
cord-322966-o65fo853	1	8	Ruth	Ruth	NNP
cord-322966-o65fo853	1	9	H.	H.	NNP
cord-322966-o65fo853	1	10	title	title	NN
cord-322966-o65fo853	1	11	:	:	:
cord-322966-o65fo853	1	12	COVID-19	covid-19	NN
cord-322966-o65fo853	1	13	–	–	:
cord-322966-o65fo853	1	14	Does	do	VBZ
cord-322966-o65fo853	1	15	This	this	DT
cord-322966-o65fo853	1	16	Disease	Disease	NNP
cord-322966-o65fo853	1	17	Kill	kill	VB
cord-322966-o65fo853	1	18	Due	due	IN
cord-322966-o65fo853	1	19	to	to	IN
cord-322966-o65fo853	1	20	Imbalance	imbalance	NN
cord-322966-o65fo853	1	21	of	of	IN
cord-322966-o65fo853	1	22	the	the	DT
cord-322966-o65fo853	1	23	Renin	Renin	NNP
cord-322966-o65fo853	1	24	Angiotensin	Angiotensin	NNP
cord-322966-o65fo853	1	25	System	System	NNP
cord-322966-o65fo853	1	26	(	(	-LRB-
cord-322966-o65fo853	1	27	RAS	RAS	NNP
cord-322966-o65fo853	1	28	)	)	-RRB-
cord-322966-o65fo853	1	29	Caused	cause	VBN
cord-322966-o65fo853	1	30	by	by	IN
cord-322966-o65fo853	1	31	Genetic	Genetic	NNP
cord-322966-o65fo853	1	32	and	and	CC
cord-322966-o65fo853	1	33	Gender	Gender	NNP
cord-322966-o65fo853	1	34	Differences	Differences	NNPS
cord-322966-o65fo853	1	35	in	in	IN
cord-322966-o65fo853	1	36	the	the	DT
cord-322966-o65fo853	1	37	Response	response	NN
cord-322966-o65fo853	1	38	to	to	IN
cord-322966-o65fo853	1	39	Viral	Viral	NNP
cord-322966-o65fo853	1	40	ACE	ACE	NNP
cord-322966-o65fo853	1	41	2	2	CD
cord-322966-o65fo853	1	42	Attacks	Attacks	NNPS
cord-322966-o65fo853	1	43	?	?	.
cord-322966-o65fo853	1	44	date	date	NN
cord-322966-o65fo853	1	45	:	:	:
cord-322966-o65fo853	1	46	2020	2020	CD
cord-322966-o65fo853	1	47	-	-	HYPH
cord-322966-o65fo853	1	48	05	05	CD
cord-322966-o65fo853	1	49	-	-	SYM
cord-322966-o65fo853	1	50	25	25	CD
cord-322966-o65fo853	1	51	journal	journal	NN
cord-322966-o65fo853	1	52	:	:	:
cord-322966-o65fo853	1	53	Heart	Heart	NNP
cord-322966-o65fo853	1	54	Lung	Lung	NNP
cord-322966-o65fo853	1	55	Circ	Circ	NNP
cord-322966-o65fo853	1	56	DOI	doi	NN
cord-322966-o65fo853	1	57	:	:	:
cord-322966-o65fo853	1	58	10.1016/	10.1016/	CD
cord-322966-o65fo853	2	1	j.hlc.2020.05.004	j.hlc.2020.05.004	NNP
cord-322966-o65fo853	2	2	sha	sha	NNP
cord-322966-o65fo853	2	3	:	:	:
cord-322966-o65fo853	2	4	11b1d49ecf68293f40d229f20729a03e3771050c	11b1d49ecf68293f40d229f20729a03e3771050c	CD
cord-322966-o65fo853	2	5	doc_id	doc_id	CD
cord-322966-o65fo853	2	6	:	:	:
cord-322966-o65fo853	2	7	322966	322966	CD
cord-322966-o65fo853	2	8	cord_uid	cord_uid	NN
cord-322966-o65fo853	2	9	:	:	:
cord-322966-o65fo853	3	1	o65fo853	o65fo853	NNP
cord-322966-o65fo853	3	2	ABSTRACT	ABSTRACT	NNP
cord-322966-o65fo853	3	3	Debate	Debate	NNP
cord-322966-o65fo853	3	4	continues	continue	VBZ
cord-322966-o65fo853	3	5	in	in	IN
cord-322966-o65fo853	3	6	the	the	DT
cord-322966-o65fo853	3	7	medical	medical	JJ
cord-322966-o65fo853	3	8	literature	literature	NN
cord-322966-o65fo853	3	9	on	on	IN
cord-322966-o65fo853	3	10	the	the	DT
cord-322966-o65fo853	3	11	role	role	NN
cord-322966-o65fo853	3	12	of	of	IN
cord-322966-o65fo853	3	13	the	the	DT
cord-322966-o65fo853	3	14	renin	renin	NN
cord-322966-o65fo853	3	15	angiotensin	angiotensin	NNP
cord-322966-o65fo853	3	16	system	system	NN
cord-322966-o65fo853	3	17	(	(	-LRB-
cord-322966-o65fo853	3	18	RAS	RAS	NNP
cord-322966-o65fo853	3	19	)	)	-RRB-
cord-322966-o65fo853	3	20	in	in	IN
cord-322966-o65fo853	3	21	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	3	22	disease	disease	NN
cord-322966-o65fo853	3	23	2019	2019	CD
cord-322966-o65fo853	3	24	(	(	-LRB-
cord-322966-o65fo853	3	25	COVID-19	COVID-19	NNP
cord-322966-o65fo853	3	26	)	)	-RRB-
cord-322966-o65fo853	3	27	pathophysiology	pathophysiology	NN
cord-322966-o65fo853	3	28	and	and	CC
cord-322966-o65fo853	3	29	the	the	DT
cord-322966-o65fo853	3	30	implications	implication	NNS
cord-322966-o65fo853	3	31	for	for	IN
cord-322966-o65fo853	3	32	the	the	DT
cord-322966-o65fo853	3	33	use	use	NN
cord-322966-o65fo853	3	34	of	of	IN
cord-322966-o65fo853	3	35	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	3	36	drugs	drug	NNS
cord-322966-o65fo853	3	37	acting	act	VBG
cord-322966-o65fo853	3	38	on	on	IN
cord-322966-o65fo853	3	39	the	the	DT
cord-322966-o65fo853	3	40	RAS	RAS	NNP
cord-322966-o65fo853	3	41	.	.	.
cord-322966-o65fo853	4	1	Could	Could	MD
cord-322966-o65fo853	4	2	these	these	DT
cord-322966-o65fo853	4	3	drugs	drug	NNS
cord-322966-o65fo853	4	4	–	–	:
cord-322966-o65fo853	4	5	which	which	WDT
cord-322966-o65fo853	4	6	include	include	VBP
cord-322966-o65fo853	4	7	angiotensin	angiotensin	NN
cord-322966-o65fo853	4	8	converting	convert	VBG
cord-322966-o65fo853	4	9	enzyme	enzyme	NN
cord-322966-o65fo853	4	10	inhibitors	inhibitor	NNS
cord-322966-o65fo853	4	11	(	(	-LRB-
cord-322966-o65fo853	4	12	ACEIs	acei	NNS
cord-322966-o65fo853	4	13	)	)	-RRB-
cord-322966-o65fo853	4	14	and	and	CC
cord-322966-o65fo853	4	15	angiotensin	angiotensin	NN
cord-322966-o65fo853	4	16	receptors	receptor	NNS
cord-322966-o65fo853	4	17	blockers	blocker	NNS
cord-322966-o65fo853	4	18	(	(	-LRB-
cord-322966-o65fo853	4	19	ARBs	arb	NNS
cord-322966-o65fo853	4	20	)	)	-RRB-
cord-322966-o65fo853	4	21	–	–	:
cord-322966-o65fo853	4	22	be	be	VB
cord-322966-o65fo853	4	23	harmful	harmful	JJ
cord-322966-o65fo853	4	24	or	or	CC
cord-322966-o65fo853	4	25	potential	potential	JJ
cord-322966-o65fo853	4	26	key	key	JJ
cord-322966-o65fo853	4	27	therapeutic	therapeutic	JJ
cord-322966-o65fo853	4	28	agents	agent	NNS
cord-322966-o65fo853	4	29	in	in	IN
cord-322966-o65fo853	4	30	COVID-19	COVID-19	NNP
cord-322966-o65fo853	4	31	?	?	.
cord-322966-o65fo853	5	1	[	[	-LRB-
cord-322966-o65fo853	5	2	ABSTRACT	abstract	JJ
cord-322966-o65fo853	5	3	]	]	-RRB-
cord-322966-o65fo853	5	4	Debate	Debate	NNP
cord-322966-o65fo853	5	5	continues	continue	VBZ
cord-322966-o65fo853	5	6	in	in	IN
cord-322966-o65fo853	5	7	the	the	DT
cord-322966-o65fo853	5	8	medical	medical	JJ
cord-322966-o65fo853	5	9	literature	literature	NN
cord-322966-o65fo853	5	10	on	on	IN
cord-322966-o65fo853	5	11	the	the	DT
cord-322966-o65fo853	5	12	role	role	NN
cord-322966-o65fo853	5	13	of	of	IN
cord-322966-o65fo853	5	14	the	the	DT
cord-322966-o65fo853	5	15	renin	renin	NN
cord-322966-o65fo853	5	16	angiotensin	angiotensin	NNP
cord-322966-o65fo853	5	17	system	system	NN
cord-322966-o65fo853	5	18	(	(	-LRB-
cord-322966-o65fo853	5	19	RAS	RAS	NNP
cord-322966-o65fo853	5	20	)	)	-RRB-
cord-322966-o65fo853	5	21	in	in	IN
cord-322966-o65fo853	5	22	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	5	23	disease	disease	NN
cord-322966-o65fo853	5	24	2019	2019	CD
cord-322966-o65fo853	5	25	(	(	-LRB-
cord-322966-o65fo853	5	26	COVID-	covid-	NN
cord-322966-o65fo853	5	27	19	19	CD
cord-322966-o65fo853	5	28	)	)	-RRB-
cord-322966-o65fo853	5	29	pathophysiology	pathophysiology	NN
cord-322966-o65fo853	5	30	and	and	CC
cord-322966-o65fo853	5	31	the	the	DT
cord-322966-o65fo853	5	32	implications	implication	NNS
cord-322966-o65fo853	5	33	for	for	IN
cord-322966-o65fo853	5	34	the	the	DT
cord-322966-o65fo853	5	35	use	use	NN
cord-322966-o65fo853	5	36	of	of	IN
cord-322966-o65fo853	5	37	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	5	38	drugs	drug	NNS
cord-322966-o65fo853	5	39	acting	act	VBG
cord-322966-o65fo853	5	40	on	on	IN
cord-322966-o65fo853	5	41	the	the	DT
cord-322966-o65fo853	5	42	RAS	RAS	NNP
cord-322966-o65fo853	5	43	.	.	.
cord-322966-o65fo853	6	1	Could	Could	MD
cord-322966-o65fo853	6	2	these	these	DT
cord-322966-o65fo853	6	3	drugs	drug	NNS
cord-322966-o65fo853	6	4	-which	-which	WDT
cord-322966-o65fo853	6	5	include	include	VBP
cord-322966-o65fo853	6	6	angiotensin	angiotensin	NN
cord-322966-o65fo853	6	7	converting	convert	VBG
cord-322966-o65fo853	6	8	enzyme	enzyme	NN
cord-322966-o65fo853	6	9	inhibitors	inhibitor	NNS
cord-322966-o65fo853	6	10	(	(	-LRB-
cord-322966-o65fo853	6	11	ACEIs	acei	NNS
cord-322966-o65fo853	6	12	)	)	-RRB-
cord-322966-o65fo853	6	13	and	and	CC
cord-322966-o65fo853	6	14	angiotensin	angiotensin	NN
cord-322966-o65fo853	6	15	receptors	receptor	NNS
cord-322966-o65fo853	6	16	blockers	blocker	NNS
cord-322966-o65fo853	6	17	(	(	-LRB-
cord-322966-o65fo853	6	18	ARBs	arb	NNS
cord-322966-o65fo853	6	19	)	)	-RRB-
cord-322966-o65fo853	6	20	-be	-be	:
cord-322966-o65fo853	6	21	harmful	harmful	JJ
cord-322966-o65fo853	6	22	or	or	CC
cord-322966-o65fo853	6	23	potential	potential	JJ
cord-322966-o65fo853	6	24	key	key	JJ
cord-322966-o65fo853	6	25	therapeutic	therapeutic	JJ
cord-322966-o65fo853	6	26	agents	agent	NNS
cord-322966-o65fo853	6	27	in	in	IN
cord-322966-o65fo853	6	28	COVID-	covid-	NN
cord-322966-o65fo853	6	29	19	19	CD
cord-322966-o65fo853	6	30	?	?	.
cord-322966-o65fo853	7	1	Debate	debate	NN
cord-322966-o65fo853	7	2	has	have	VBZ
cord-322966-o65fo853	7	3	arisen	arise	VBN
cord-322966-o65fo853	7	4	due	due	IN
cord-322966-o65fo853	7	5	to	to	IN
cord-322966-o65fo853	7	6	the	the	DT
cord-322966-o65fo853	7	7	finding	finding	NN
cord-322966-o65fo853	7	8	that	that	IN
cord-322966-o65fo853	7	9	underlying	underlie	VBG
cord-322966-o65fo853	7	10	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	7	11	disease	disease	NN
cord-322966-o65fo853	7	12	and	and	CC
cord-322966-o65fo853	7	13	hypertension	hypertension	NN
cord-322966-o65fo853	7	14	are	be	VBP
cord-322966-o65fo853	7	15	associated	associate	VBN
cord-322966-o65fo853	7	16	with	with	IN
cord-322966-o65fo853	7	17	significantly	significantly	RB
cord-322966-o65fo853	7	18	increased	increase	VBN
cord-322966-o65fo853	7	19	risk	risk	NN
cord-322966-o65fo853	7	20	of	of	IN
cord-322966-o65fo853	7	21	hospitalisation	hospitalisation	NN
cord-322966-o65fo853	7	22	and	and	CC
cord-322966-o65fo853	7	23	death	death	NN
cord-322966-o65fo853	7	24	in	in	IN
cord-322966-o65fo853	7	25	COVID-19	COVID-19	NNP
cord-322966-o65fo853	7	26	[	[	-LRB-
cord-322966-o65fo853	7	27	1	1	CD
cord-322966-o65fo853	7	28	,	,	,
cord-322966-o65fo853	7	29	2	2	CD
cord-322966-o65fo853	7	30	]	]	-RRB-
cord-322966-o65fo853	7	31	,	,	,
cord-322966-o65fo853	7	32	in	in	IN
cord-322966-o65fo853	7	33	addition	addition	NN
cord-322966-o65fo853	7	34	to	to	IN
cord-322966-o65fo853	7	35	the	the	DT
cord-322966-o65fo853	7	36	viral	viral	JJ
cord-322966-o65fo853	7	37	receptor	receptor	NN
cord-322966-o65fo853	7	38	being	be	VBG
cord-322966-o65fo853	7	39	angiotensin	angiotensin	NN
cord-322966-o65fo853	7	40	-	-	HYPH
cord-322966-o65fo853	7	41	converting	convert	VBG
cord-322966-o65fo853	7	42	enzyme-2	enzyme-2	NNP
cord-322966-o65fo853	8	1	(	(	-LRB-
cord-322966-o65fo853	8	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	8	3	)	)	-RRB-
cord-322966-o65fo853	8	4	[	[	-LRB-
cord-322966-o65fo853	8	5	3	3	CD
cord-322966-o65fo853	8	6	-5	-5	NNP
cord-322966-o65fo853	8	7	]	]	-RRB-
cord-322966-o65fo853	8	8	.	.	.
cord-322966-o65fo853	9	1	Coronaviruses	coronaviruse	NNS
cord-322966-o65fo853	9	2	downregulate	downregulate	VBP
cord-322966-o65fo853	9	3	ACE-2	ACE-2	NNP
cord-322966-o65fo853	9	4	anti	anti	JJ
cord-322966-o65fo853	9	5	-	-	JJ
cord-322966-o65fo853	9	6	inflammatory	inflammatory	JJ
cord-322966-o65fo853	9	7	actions	action	NNS
cord-322966-o65fo853	9	8	leading	lead	VBG
cord-322966-o65fo853	9	9	to	to	IN
cord-322966-o65fo853	9	10	imbalance	imbalance	NN
cord-322966-o65fo853	9	11	in	in	IN
cord-322966-o65fo853	9	12	ACE	ace	NN
cord-322966-o65fo853	9	13	:	:	:
cord-322966-o65fo853	10	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	10	2	[	[	-LRB-
cord-322966-o65fo853	10	3	4	4	CD
cord-322966-o65fo853	10	4	]	]	-RRB-
cord-322966-o65fo853	10	5	which	which	WDT
cord-322966-o65fo853	10	6	may	may	MD
cord-322966-o65fo853	10	7	be	be	VB
cord-322966-o65fo853	10	8	fundamental	fundamental	JJ
cord-322966-o65fo853	10	9	in	in	IN
cord-322966-o65fo853	10	10	COVID-19	covid-19	JJ
cord-322966-o65fo853	10	11	pathophysiology	pathophysiology	NN
cord-322966-o65fo853	10	12	.	.	.
cord-322966-o65fo853	11	1	Key	key	JJ
cord-322966-o65fo853	11	2	gender	gender	NN
cord-322966-o65fo853	11	3	and	and	CC
cord-322966-o65fo853	11	4	genetic	genetic	JJ
cord-322966-o65fo853	11	5	differences	difference	NNS
cord-322966-o65fo853	11	6	in	in	IN
cord-322966-o65fo853	11	7	the	the	DT
cord-322966-o65fo853	11	8	regulation	regulation	NN
cord-322966-o65fo853	11	9	of	of	IN
cord-322966-o65fo853	11	10	ACE	ace	NN
cord-322966-o65fo853	11	11	:	:	:
cord-322966-o65fo853	12	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	12	2	balance	balance	NN
cord-322966-o65fo853	12	3	[	[	-LRB-
cord-322966-o65fo853	12	4	6	6	CD
cord-322966-o65fo853	12	5	]	]	-RRB-
cord-322966-o65fo853	12	6	[	[	-LRB-
cord-322966-o65fo853	12	7	7	7	CD
cord-322966-o65fo853	12	8	]	]	-RRB-
cord-322966-o65fo853	13	1	[	[	-LRB-
cord-322966-o65fo853	13	2	8	8	CD
cord-322966-o65fo853	13	3	]	]	-RRB-
cord-322966-o65fo853	13	4	may	may	MD
cord-322966-o65fo853	13	5	explain	explain	VB
cord-322966-o65fo853	13	6	differences	difference	NNS
cord-322966-o65fo853	13	7	observed	observe	VBN
cord-322966-o65fo853	13	8	in	in	IN
cord-322966-o65fo853	13	9	disease	disease	NN
cord-322966-o65fo853	13	10	severity	severity	NN
cord-322966-o65fo853	13	11	[	[	-LRB-
cord-322966-o65fo853	13	12	2	2	CD
cord-322966-o65fo853	13	13	,	,	,
cord-322966-o65fo853	13	14	9	9	CD
cord-322966-o65fo853	13	15	,	,	,
cord-322966-o65fo853	13	16	10	10	CD
cord-322966-o65fo853	13	17	]	]	-RRB-
cord-322966-o65fo853	13	18	.	.	.
cord-322966-o65fo853	14	1	Social	social	JJ
cord-322966-o65fo853	14	2	media	medium	NNS
cord-322966-o65fo853	14	3	amplification	amplification	NN
cord-322966-o65fo853	14	4	of	of	IN
cord-322966-o65fo853	14	5	concern	concern	NN
cord-322966-o65fo853	14	6	about	about	IN
cord-322966-o65fo853	14	7	continuation	continuation	NN
cord-322966-o65fo853	14	8	of	of	IN
cord-322966-o65fo853	14	9	RAS	RAS	NNP
cord-322966-o65fo853	14	10	medications	medication	NNS
cord-322966-o65fo853	14	11	during	during	IN
cord-322966-o65fo853	14	12	the	the	DT
cord-322966-o65fo853	14	13	current	current	JJ
cord-322966-o65fo853	14	14	pandemic	pandemic	NN
cord-322966-o65fo853	14	15	prompted	prompt	VBD
cord-322966-o65fo853	14	16	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	14	17	societies	society	NNS
cord-322966-o65fo853	14	18	to	to	TO
cord-322966-o65fo853	14	19	publish	publish	VB
cord-322966-o65fo853	14	20	position	position	NN
cord-322966-o65fo853	14	21	statements	statement	NNS
cord-322966-o65fo853	14	22	strongly	strongly	RB
cord-322966-o65fo853	14	23	advising	advise	VBG
cord-322966-o65fo853	14	24	continued	continue	VBN
cord-322966-o65fo853	14	25	use	use	NN
cord-322966-o65fo853	14	26	,	,	,
cord-322966-o65fo853	14	27	given	give	VBN
cord-322966-o65fo853	14	28	a	a	DT
cord-322966-o65fo853	14	29	lack	lack	NN
cord-322966-o65fo853	14	30	of	of	IN
cord-322966-o65fo853	14	31	evidence	evidence	NN
cord-322966-o65fo853	14	32	that	that	IN
cord-322966-o65fo853	14	33	RAS	RAS	NNP
cord-322966-o65fo853	14	34	drugs	drug	NNS
cord-322966-o65fo853	14	35	were	be	VBD
cord-322966-o65fo853	14	36	unsafe	unsafe	JJ
cord-322966-o65fo853	14	37	and	and	CC
cord-322966-o65fo853	14	38	the	the	DT
cord-322966-o65fo853	14	39	substantial	substantial	JJ
cord-322966-o65fo853	14	40	risk	risk	NN
cord-322966-o65fo853	14	41	of	of	IN
cord-322966-o65fo853	14	42	hospitalisation	hospitalisation	NN
cord-322966-o65fo853	14	43	when	when	WRB
cord-322966-o65fo853	14	44	these	these	DT
cord-322966-o65fo853	14	45	drugs	drug	NNS
cord-322966-o65fo853	14	46	are	be	VBP
cord-322966-o65fo853	14	47	withdrawn	withdraw	VBN
cord-322966-o65fo853	14	48	from	from	IN
cord-322966-o65fo853	14	49	patients	patient	NNS
cord-322966-o65fo853	14	50	with	with	IN
cord-322966-o65fo853	14	51	valid	valid	JJ
cord-322966-o65fo853	14	52	indications	indication	NNS
cord-322966-o65fo853	14	53	for	for	IN
cord-322966-o65fo853	14	54	treatment	treatment	NN
cord-322966-o65fo853	14	55	[	[	-LRB-
cord-322966-o65fo853	14	56	11	11	CD
cord-322966-o65fo853	14	57	,	,	,
cord-322966-o65fo853	14	58	12	12	CD
cord-322966-o65fo853	14	59	]	]	-RRB-
cord-322966-o65fo853	14	60	.	.	.
cord-322966-o65fo853	15	1	Three	three	CD
cord-322966-o65fo853	15	2	(	(	-LRB-
cord-322966-o65fo853	15	3	3	3	CD
cord-322966-o65fo853	15	4	)	)	-RRB-
cord-322966-o65fo853	15	5	large	large	JJ
cord-322966-o65fo853	15	6	observational	observational	JJ
cord-322966-o65fo853	15	7	studies	study	NNS
cord-322966-o65fo853	15	8	published	publish	VBN
cord-322966-o65fo853	15	9	in	in	IN
cord-322966-o65fo853	15	10	The	the	DT
cord-322966-o65fo853	15	11	New	New	NNP
cord-322966-o65fo853	15	12	England	England	NNP
cord-322966-o65fo853	15	13	Journal	Journal	NNP
cord-322966-o65fo853	15	14	of	of	IN
cord-322966-o65fo853	15	15	Medicine	Medicine	NNP
cord-322966-o65fo853	15	16	(	(	-LRB-
cord-322966-o65fo853	15	17	NEJM	NEJM	NNP
cord-322966-o65fo853	15	18	]	]	-RRB-
cord-322966-o65fo853	15	19	now	now	RB
cord-322966-o65fo853	15	20	support	support	VBP
cord-322966-o65fo853	15	21	the	the	DT
cord-322966-o65fo853	15	22	view	view	NN
cord-322966-o65fo853	15	23	that	that	IN
cord-322966-o65fo853	15	24	there	there	EX
cord-322966-o65fo853	15	25	is	be	VBZ
cord-322966-o65fo853	15	26	no	no	DT
cord-322966-o65fo853	15	27	evidence	evidence	NN
cord-322966-o65fo853	15	28	for	for	IN
cord-322966-o65fo853	15	29	harm	harm	NN
cord-322966-o65fo853	15	30	due	due	IN
cord-322966-o65fo853	15	31	to	to	IN
cord-322966-o65fo853	15	32	RAS	RAS	NNP
cord-322966-o65fo853	15	33	medications	medication	NNS
cord-322966-o65fo853	15	34	in	in	IN
cord-322966-o65fo853	15	35	COVID-19	COVID-19	NNP
cord-322966-o65fo853	15	36	[	[	-LRB-
cord-322966-o65fo853	15	37	10	10	CD
cord-322966-o65fo853	15	38	,	,	,
cord-322966-o65fo853	15	39	13	13	CD
cord-322966-o65fo853	15	40	,	,	,
cord-322966-o65fo853	15	41	14	14	CD
cord-322966-o65fo853	15	42	]	]	-RRB-
cord-322966-o65fo853	15	43	.	.	.
cord-322966-o65fo853	16	1	However	however	RB
cord-322966-o65fo853	16	2	,	,	,
cord-322966-o65fo853	16	3	given	give	VBN
cord-322966-o65fo853	16	4	the	the	DT
cord-322966-o65fo853	16	5	fundamental	fundamental	JJ
cord-322966-o65fo853	16	6	role	role	NN
cord-322966-o65fo853	16	7	of	of	IN
cord-322966-o65fo853	16	8	the	the	DT
cord-322966-o65fo853	16	9	(	(	-LRB-
cord-322966-o65fo853	16	10	RAS	RAS	NNP
cord-322966-o65fo853	16	11	)	)	-RRB-
cord-322966-o65fo853	16	12	in	in	IN
cord-322966-o65fo853	16	13	COVID-19	COVID-19	NNP
cord-322966-o65fo853	16	14	,	,	,
cord-322966-o65fo853	16	15	a	a	DT
cord-322966-o65fo853	16	16	broader	broader	RBR
cord-322966-o65fo853	16	17	therapeutic	therapeutic	JJ
cord-322966-o65fo853	16	18	indication	indication	NN
cord-322966-o65fo853	16	19	for	for	IN
cord-322966-o65fo853	16	20	ACEI	ACEI	NNP
cord-322966-o65fo853	16	21	and	and	CC
cord-322966-o65fo853	16	22	ARBs	arb	NNS
cord-322966-o65fo853	16	23	,	,	,
cord-322966-o65fo853	16	24	over	over	RB
cord-322966-o65fo853	16	25	and	and	CC
cord-322966-o65fo853	16	26	above	above	IN
cord-322966-o65fo853	16	27	treatment	treatment	NN
cord-322966-o65fo853	16	28	of	of	IN
cord-322966-o65fo853	16	29	patients	patient	NNS
cord-322966-o65fo853	16	30	with	with	IN
cord-322966-o65fo853	16	31	established	established	JJ
cord-322966-o65fo853	16	32	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	16	33	indications	indication	NNS
cord-322966-o65fo853	16	34	has	have	VBZ
cord-322966-o65fo853	16	35	been	be	VBN
cord-322966-o65fo853	16	36	suggested	suggest	VBN
cord-322966-o65fo853	16	37	[	[	-LRB-
cord-322966-o65fo853	16	38	15	15	CD
cord-322966-o65fo853	16	39	,	,	,
cord-322966-o65fo853	16	40	16	16	CD
cord-322966-o65fo853	16	41	]	]	-RRB-
cord-322966-o65fo853	16	42	but	but	CC
cord-322966-o65fo853	16	43	is	be	VBZ
cord-322966-o65fo853	16	44	yet	yet	RB
cord-322966-o65fo853	16	45	to	to	TO
cord-322966-o65fo853	16	46	be	be	VB
cord-322966-o65fo853	16	47	tested	test	VBN
cord-322966-o65fo853	16	48	in	in	IN
cord-322966-o65fo853	16	49	randomised	randomised	JJ
cord-322966-o65fo853	16	50	trials	trial	NNS
cord-322966-o65fo853	16	51	.	.	.
cord-322966-o65fo853	17	1	Vitamin	vitamin	NN
cord-322966-o65fo853	17	2	D	d	NN
cord-322966-o65fo853	17	3	status	status	NN
cord-322966-o65fo853	17	4	may	may	MD
cord-322966-o65fo853	17	5	also	also	RB
cord-322966-o65fo853	17	6	be	be	VB
cord-322966-o65fo853	17	7	linked	link	VBN
cord-322966-o65fo853	17	8	to	to	IN
cord-322966-o65fo853	17	9	the	the	DT
cord-322966-o65fo853	17	10	RAS	RAS	NNP
cord-322966-o65fo853	17	11	impacts	impact	NNS
cord-322966-o65fo853	17	12	of	of	IN
cord-322966-o65fo853	17	13	COVID-19	COVID-19	NNP
cord-322966-o65fo853	17	14	,	,	,
cord-322966-o65fo853	17	15	as	as	IN
cord-322966-o65fo853	17	16	vitamin	vitamin	NN
cord-322966-o65fo853	17	17	D	d	NN
cord-322966-o65fo853	17	18	is	be	VBZ
cord-322966-o65fo853	17	19	a	a	DT
cord-322966-o65fo853	17	20	negative	negative	JJ
cord-322966-o65fo853	17	21	regulator	regulator	NN
cord-322966-o65fo853	17	22	of	of	IN
cord-322966-o65fo853	17	23	renin	renin	NN
cord-322966-o65fo853	17	24	synthesis	synthesis	NN
cord-322966-o65fo853	17	25	,	,	,
cord-322966-o65fo853	17	26	and	and	CC
cord-322966-o65fo853	17	27	a	a	DT
cord-322966-o65fo853	17	28	small	small	JJ
cord-322966-o65fo853	17	29	study	study	NN
cord-322966-o65fo853	17	30	has	have	VBZ
cord-322966-o65fo853	17	31	reported	report	VBN
cord-322966-o65fo853	17	32	high	high	JJ
cord-322966-o65fo853	17	33	rates	rate	NNS
cord-322966-o65fo853	17	34	of	of	IN
cord-322966-o65fo853	17	35	vitamin	vitamin	NN
cord-322966-o65fo853	17	36	D	d	NN
cord-322966-o65fo853	17	37	deficiency	deficiency	NN
cord-322966-o65fo853	17	38	in	in	IN
cord-322966-o65fo853	17	39	COVID	COVID	NNP
cord-322966-o65fo853	17	40	patients	patient	NNS
cord-322966-o65fo853	17	41	requiring	require	VBG
cord-322966-o65fo853	17	42	intensive	intensive	JJ
cord-322966-o65fo853	17	43	care	care	NN
cord-322966-o65fo853	17	44	[	[	-LRB-
cord-322966-o65fo853	17	45	17	17	CD
cord-322966-o65fo853	17	46	]	]	-RRB-
cord-322966-o65fo853	17	47	.	.	.
cord-322966-o65fo853	18	1	Both	both	DT
cord-322966-o65fo853	18	2	vitamin	vitamin	NN
cord-322966-o65fo853	18	3	D	d	NN
cord-322966-o65fo853	18	4	and	and	CC
cord-322966-o65fo853	18	5	ACE	ACE	NNP
cord-322966-o65fo853	18	6	have	have	VBP
cord-322966-o65fo853	18	7	a	a	DT
cord-322966-o65fo853	18	8	role	role	NN
cord-322966-o65fo853	18	9	in	in	IN
cord-322966-o65fo853	18	10	the	the	DT
cord-322966-o65fo853	18	11	immune	immune	JJ
cord-322966-o65fo853	18	12	system	system	NN
cord-322966-o65fo853	18	13	,	,	,
cord-322966-o65fo853	18	14	which	which	WDT
cord-322966-o65fo853	18	15	may	may	MD
cord-322966-o65fo853	18	16	add	add	VB
cord-322966-o65fo853	18	17	a	a	DT
cord-322966-o65fo853	18	18	complex	complex	JJ
cord-322966-o65fo853	18	19	dimension	dimension	NN
cord-322966-o65fo853	18	20	to	to	IN
cord-322966-o65fo853	18	21	the	the	DT
cord-322966-o65fo853	18	22	issue	issue	NN
cord-322966-o65fo853	18	23	of	of	IN
cord-322966-o65fo853	18	24	RAS	RAS	NNP
cord-322966-o65fo853	18	25	drugs	drug	NNS
cord-322966-o65fo853	18	26	and	and	CC
cord-322966-o65fo853	18	27	vitamin	vitamin	NN
cord-322966-o65fo853	18	28	D	d	NN
cord-322966-o65fo853	18	29	status	status	NN
cord-322966-o65fo853	18	30	in	in	IN
cord-322966-o65fo853	18	31	COVID-19	COVID-19	NNP
cord-322966-o65fo853	18	32	[	[	-LRB-
cord-322966-o65fo853	18	33	18	18	CD
cord-322966-o65fo853	18	34	,	,	,
cord-322966-o65fo853	18	35	19	19	CD
cord-322966-o65fo853	18	36	]	]	-RRB-
cord-322966-o65fo853	18	37	.	.	.
cord-322966-o65fo853	19	1	COVID-19	COVID-19	NNP
cord-322966-o65fo853	19	2	has	have	VBZ
cord-322966-o65fo853	19	3	a	a	DT
cord-322966-o65fo853	19	4	more	more	RBR
cord-322966-o65fo853	19	5	severe	severe	JJ
cord-322966-o65fo853	19	6	course	course	NN
cord-322966-o65fo853	19	7	in	in	IN
cord-322966-o65fo853	19	8	patients	patient	NNS
cord-322966-o65fo853	19	9	with	with	IN
cord-322966-o65fo853	19	10	pre	pre	JJ
cord-322966-o65fo853	19	11	-	-	JJ
cord-322966-o65fo853	19	12	existing	existing	JJ
cord-322966-o65fo853	19	13	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	19	14	disease	disease	NN
cord-322966-o65fo853	19	15	[	[	-LRB-
cord-322966-o65fo853	19	16	1	1	CD
cord-322966-o65fo853	19	17	,	,	,
cord-322966-o65fo853	19	18	2	2	CD
cord-322966-o65fo853	19	19	,	,	,
cord-322966-o65fo853	19	20	10	10	CD
cord-322966-o65fo853	19	21	]	]	-RRB-
cord-322966-o65fo853	19	22	and	and	CC
cord-322966-o65fo853	19	23	causes	cause	VBZ
cord-322966-o65fo853	19	24	a	a	DT
cord-322966-o65fo853	19	25	significant	significant	JJ
cord-322966-o65fo853	19	26	rate	rate	NN
cord-322966-o65fo853	19	27	of	of	IN
cord-322966-o65fo853	19	28	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	19	29	events	event	NNS
cord-322966-o65fo853	19	30	[	[	-LRB-
cord-322966-o65fo853	19	31	20	20	CD
cord-322966-o65fo853	19	32	]	]	-RRB-
cord-322966-o65fo853	19	33	.	.	.
cord-322966-o65fo853	20	1	Further	further	JJ
cord-322966-o65fo853	20	2	research	research	NN
cord-322966-o65fo853	20	3	is	be	VBZ
cord-322966-o65fo853	20	4	required	require	VBN
cord-322966-o65fo853	20	5	to	to	TO
cord-322966-o65fo853	20	6	define	define	VB
cord-322966-o65fo853	20	7	the	the	DT
cord-322966-o65fo853	20	8	pathological	pathological	JJ
cord-322966-o65fo853	20	9	mechanisms	mechanism	NNS
cord-322966-o65fo853	20	10	and	and	CC
cord-322966-o65fo853	20	11	the	the	DT
cord-322966-o65fo853	20	12	basis	basis	NN
cord-322966-o65fo853	20	13	for	for	IN
cord-322966-o65fo853	20	14	the	the	DT
cord-322966-o65fo853	20	15	observed	observed	JJ
cord-322966-o65fo853	20	16	gender	gender	NN
cord-322966-o65fo853	20	17	,	,	,
cord-322966-o65fo853	20	18	age	age	NN
cord-322966-o65fo853	20	19	,	,	,
cord-322966-o65fo853	20	20	and	and	CC
cord-322966-o65fo853	20	21	racial	racial	JJ
cord-322966-o65fo853	20	22	differences	difference	NNS
cord-322966-o65fo853	20	23	in	in	IN
cord-322966-o65fo853	20	24	severity	severity	NN
cord-322966-o65fo853	20	25	.	.	.
cord-322966-o65fo853	21	1	RAS	RAS	NNP
cord-322966-o65fo853	21	2	medications	medication	NNS
cord-322966-o65fo853	21	3	can	can	MD
cord-322966-o65fo853	21	4	be	be	VB
cord-322966-o65fo853	21	5	used	use	VBN
cord-322966-o65fo853	21	6	with	with	IN
cord-322966-o65fo853	21	7	greater	great	JJR
cord-322966-o65fo853	21	8	confidence	confidence	NN
cord-322966-o65fo853	21	9	in	in	IN
cord-322966-o65fo853	21	10	COVID-19	covid-19	JJ
cord-322966-o65fo853	21	11	patients	patient	NNS
cord-322966-o65fo853	21	12	with	with	IN
cord-322966-o65fo853	21	13	valid	valid	JJ
cord-322966-o65fo853	21	14	indications	indication	NNS
cord-322966-o65fo853	21	15	for	for	IN
cord-322966-o65fo853	21	16	their	-PRON-	PRP$
cord-322966-o65fo853	21	17	use	use	NN
cord-322966-o65fo853	21	18	,	,	,
cord-322966-o65fo853	21	19	but	but	CC
cord-322966-o65fo853	21	20	a	a	DT
cord-322966-o65fo853	21	21	broader	broad	JJR
cord-322966-o65fo853	21	22	role	role	NN
cord-322966-o65fo853	21	23	for	for	IN
cord-322966-o65fo853	21	24	manipulation	manipulation	NN
cord-322966-o65fo853	21	25	of	of	IN
cord-322966-o65fo853	21	26	the	the	DT
cord-322966-o65fo853	21	27	RAS	RAS	NNP
cord-322966-o65fo853	21	28	in	in	IN
cord-322966-o65fo853	21	29	COVID-19	COVID-19	NNP
cord-322966-o65fo853	21	30	will	will	MD
cord-322966-o65fo853	21	31	require	require	VB
cord-322966-o65fo853	21	32	randomised	randomised	JJ
cord-322966-o65fo853	21	33	trial	trial	NN
cord-322966-o65fo853	21	34	data	datum	NNS
cord-322966-o65fo853	21	35	.	.	.
cord-322966-o65fo853	22	1	Coronavirus-2	Coronavirus-2	NNP
cord-322966-o65fo853	23	1	(	(	-LRB-
cord-322966-o65fo853	23	2	SARS	SARS	NNP
cord-322966-o65fo853	23	3	-	-	HYPH
cord-322966-o65fo853	23	4	CoV-19	CoV-19	NNP
cord-322966-o65fo853	23	5	)	)	-RRB-
cord-322966-o65fo853	23	6	is	be	VBZ
cord-322966-o65fo853	23	7	believed	believe	VBN
cord-322966-o65fo853	23	8	to	to	TO
cord-322966-o65fo853	23	9	gain	gain	VB
cord-322966-o65fo853	23	10	cell	cell	NN
cord-322966-o65fo853	23	11	entry	entry	NN
cord-322966-o65fo853	23	12	via	via	IN
cord-322966-o65fo853	23	13	viral	viral	JJ
cord-322966-o65fo853	23	14	spike	spike	NN
cord-322966-o65fo853	23	15	protein	protein	NN
cord-322966-o65fo853	23	16	binding	bind	VBG
cord-322966-o65fo853	23	17	to	to	IN
cord-322966-o65fo853	23	18	the	the	DT
cord-322966-o65fo853	23	19	ACE-2	ACE-2	NNP
cord-322966-o65fo853	23	20	receptor	receptor	NN
cord-322966-o65fo853	23	21	[	[	-LRB-
cord-322966-o65fo853	23	22	3	3	CD
cord-322966-o65fo853	23	23	,	,	,
cord-322966-o65fo853	23	24	4	4	CD
cord-322966-o65fo853	23	25	]	]	-RRB-
cord-322966-o65fo853	23	26	.	.	.
cord-322966-o65fo853	24	1	Virology	virology	NN
cord-322966-o65fo853	24	2	research	research	NN
cord-322966-o65fo853	24	3	for	for	IN
cord-322966-o65fo853	24	4	other	other	JJ
cord-322966-o65fo853	24	5	similar	similar	JJ
cord-322966-o65fo853	24	6	coronaviruses	coronaviruse	NNS
cord-322966-o65fo853	24	7	indicates	indicate	VBZ
cord-322966-o65fo853	24	8	that	that	IN
cord-322966-o65fo853	24	9	viral	viral	JJ
cord-322966-o65fo853	24	10	cell	cell	NN
cord-322966-o65fo853	24	11	infection	infection	NN
cord-322966-o65fo853	24	12	is	be	VBZ
cord-322966-o65fo853	24	13	followed	follow	VBN
cord-322966-o65fo853	24	14	by	by	IN
cord-322966-o65fo853	24	15	rapid	rapid	JJ
cord-322966-o65fo853	24	16	downregulation	downregulation	NN
cord-322966-o65fo853	24	17	of	of	IN
cord-322966-o65fo853	24	18	ACE-2	ACE-2	NNP
cord-322966-o65fo853	24	19	[	[	-LRB-
cord-322966-o65fo853	24	20	4	4	CD
cord-322966-o65fo853	24	21	,	,	,
cord-322966-o65fo853	24	22	5	5	CD
cord-322966-o65fo853	24	23	]	]	-RRB-
cord-322966-o65fo853	24	24	.	.	.
cord-322966-o65fo853	25	1	The	the	DT
cord-322966-o65fo853	25	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	25	3	system	system	NN
cord-322966-o65fo853	25	4	is	be	VBZ
cord-322966-o65fo853	25	5	the	the	DT
cord-322966-o65fo853	25	6	yang	yang	NNP
cord-322966-o65fo853	25	7	of	of	IN
cord-322966-o65fo853	25	8	the	the	DT
cord-322966-o65fo853	25	9	yin	yin	NNP
cord-322966-o65fo853	25	10	-	-	HYPH
cord-322966-o65fo853	25	11	yang	yang	NNP
cord-322966-o65fo853	25	12	balance	balance	NN
cord-322966-o65fo853	25	13	of	of	IN
cord-322966-o65fo853	25	14	the	the	DT
cord-322966-o65fo853	25	15	RAS	RAS	NNP
cord-322966-o65fo853	25	16	hypertension	hypertension	NN
cord-322966-o65fo853	25	17	system	system	NN
cord-322966-o65fo853	25	18	.	.	.
cord-322966-o65fo853	26	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	26	2	is	be	VBZ
cord-322966-o65fo853	26	3	a	a	DT
cord-322966-o65fo853	26	4	zinc	zinc	NN
cord-322966-o65fo853	26	5	metalloprotease	metalloprotease	NN
cord-322966-o65fo853	26	6	,	,	,
cord-322966-o65fo853	26	7	discovered	discover	VBN
cord-322966-o65fo853	26	8	in	in	IN
cord-322966-o65fo853	26	9	2000	2000	CD
cord-322966-o65fo853	26	10	[	[	-LRB-
cord-322966-o65fo853	26	11	21	21	CD
cord-322966-o65fo853	26	12	]	]	-RRB-
cord-322966-o65fo853	26	13	,	,	,
cord-322966-o65fo853	26	14	which	which	WDT
cord-322966-o65fo853	26	15	mainly	mainly	RB
cord-322966-o65fo853	26	16	breaks	break	VBZ
cord-322966-o65fo853	26	17	down	down	RP
cord-322966-o65fo853	26	18	angiotensin	angiotensin	NN
cord-322966-o65fo853	26	19	II	II	NNP
cord-322966-o65fo853	26	20	(	(	-LRB-
cord-322966-o65fo853	26	21	Ang	Ang	NNP
cord-322966-o65fo853	26	22	II	II	NNP
cord-322966-o65fo853	26	23	)	)	-RRB-
cord-322966-o65fo853	26	24	,	,	,
cord-322966-o65fo853	26	25	the	the	DT
cord-322966-o65fo853	26	26	main	main	JJ
cord-322966-o65fo853	26	27	effector	effector	NN
cord-322966-o65fo853	26	28	of	of	IN
cord-322966-o65fo853	26	29	the	the	DT
cord-322966-o65fo853	26	30	RAS	RAS	NNP
cord-322966-o65fo853	26	31	system	system	NN
cord-322966-o65fo853	26	32	,	,	,
cord-322966-o65fo853	26	33	to	to	IN
cord-322966-o65fo853	26	34	Ang(1	Ang(1	NNP
cord-322966-o65fo853	26	35	-	-	HYPH
cord-322966-o65fo853	26	36	7	7	CD
cord-322966-o65fo853	26	37	)	)	-RRB-
cord-322966-o65fo853	26	38	,	,	,
cord-322966-o65fo853	26	39	resulting	result	VBG
cord-322966-o65fo853	26	40	in	in	IN
cord-322966-o65fo853	26	41	a	a	DT
cord-322966-o65fo853	26	42	decrease	decrease	NN
cord-322966-o65fo853	26	43	in	in	IN
cord-322966-o65fo853	26	44	blood	blood	NN
cord-322966-o65fo853	26	45	pressure	pressure	NN
cord-322966-o65fo853	26	46	,	,	,
cord-322966-o65fo853	26	47	vasoconstriction	vasoconstriction	NN
cord-322966-o65fo853	26	48	and	and	CC
cord-322966-o65fo853	26	49	decreased	decrease	VBD
cord-322966-o65fo853	26	50	inflammation	inflammation	NN
cord-322966-o65fo853	26	51	.	.	.
cord-322966-o65fo853	27	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	27	2	is	be	VBZ
cord-322966-o65fo853	27	3	usually	usually	RB
cord-322966-o65fo853	27	4	membrane	membrane	NN
cord-322966-o65fo853	27	5	bound	bind	VBN
cord-322966-o65fo853	27	6	but	but	CC
cord-322966-o65fo853	27	7	is	be	VBZ
cord-322966-o65fo853	27	8	shed	shed	VBN
cord-322966-o65fo853	27	9	in	in	IN
cord-322966-o65fo853	27	10	COVID	COVID	NNP
cord-322966-o65fo853	27	11	infection	infection	NN
cord-322966-o65fo853	27	12	,	,	,
cord-322966-o65fo853	27	13	in	in	IN
cord-322966-o65fo853	27	14	acute	acute	JJ
cord-322966-o65fo853	27	15	lung	lung	NN
cord-322966-o65fo853	27	16	injury	injury	NN
cord-322966-o65fo853	27	17	and	and	CC
cord-322966-o65fo853	27	18	myocardial	myocardial	JJ
cord-322966-o65fo853	27	19	infarction	infarction	NN
cord-322966-o65fo853	27	20	[	[	-LRB-
cord-322966-o65fo853	27	21	16	16	CD
cord-322966-o65fo853	27	22	]	]	-RRB-
cord-322966-o65fo853	27	23	.	.	.
cord-322966-o65fo853	28	1	Whilst	whilst	IN
cord-322966-o65fo853	28	2	the	the	DT
cord-322966-o65fo853	28	3	role	role	NN
cord-322966-o65fo853	28	4	of	of	IN
cord-322966-o65fo853	28	5	circulating	circulate	VBG
cord-322966-o65fo853	28	6	ACE-2	ACE-2	NNP
cord-322966-o65fo853	28	7	is	be	VBZ
cord-322966-o65fo853	28	8	unclear	unclear	JJ
cord-322966-o65fo853	28	9	,	,	,
cord-322966-o65fo853	28	10	conditions	condition	NNS
cord-322966-o65fo853	28	11	such	such	JJ
cord-322966-o65fo853	28	12	as	as	IN
cord-322966-o65fo853	28	13	advanced	advanced	JJ
cord-322966-o65fo853	28	14	heart	heart	NN
cord-322966-o65fo853	28	15	failure	failure	NN
cord-322966-o65fo853	28	16	have	have	VBP
cord-322966-o65fo853	28	17	higher	high	JJR
cord-322966-o65fo853	28	18	plasma	plasma	NN
cord-322966-o65fo853	28	19	ACE-2	ACE-2	NNP
cord-322966-o65fo853	28	20	proportional	proportional	JJ
cord-322966-o65fo853	28	21	to	to	IN
cord-322966-o65fo853	28	22	worsening	worsen	VBG
cord-322966-o65fo853	28	23	clinical	clinical	JJ
cord-322966-o65fo853	28	24	status	status	NN
cord-322966-o65fo853	28	25	[	[	-LRB-
cord-322966-o65fo853	28	26	22	22	CD
cord-322966-o65fo853	28	27	,	,	,
cord-322966-o65fo853	28	28	23	23	CD
cord-322966-o65fo853	28	29	]	]	-RRB-
cord-322966-o65fo853	28	30	.	.	.
cord-322966-o65fo853	29	1	Serum	serum	NN
cord-322966-o65fo853	29	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	29	3	levels	level	NNS
cord-322966-o65fo853	29	4	are	be	VBP
cord-322966-o65fo853	29	5	also	also	RB
cord-322966-o65fo853	29	6	significantly	significantly	RB
cord-322966-o65fo853	29	7	higher	high	JJR
cord-322966-o65fo853	29	8	in	in	IN
cord-322966-o65fo853	29	9	hypertensive	hypertensive	JJ
cord-322966-o65fo853	29	10	patients	patient	NNS
cord-322966-o65fo853	29	11	[	[	-LRB-
cord-322966-o65fo853	29	12	23	23	CD
cord-322966-o65fo853	29	13	]	]	-RRB-
cord-322966-o65fo853	29	14	and	and	CC
cord-322966-o65fo853	29	15	gender	gender	NN
cord-322966-o65fo853	29	16	differences	difference	NNS
cord-322966-o65fo853	29	17	are	be	VBP
cord-322966-o65fo853	29	18	described	describe	VBN
cord-322966-o65fo853	29	19	with	with	IN
cord-322966-o65fo853	29	20	up	up	IN
cord-322966-o65fo853	29	21	to	to	TO
cord-322966-o65fo853	29	22	50	50	CD
cord-322966-o65fo853	29	23	%	%	NN
cord-322966-o65fo853	29	24	greater	great	JJR
cord-322966-o65fo853	29	25	levels	level	NNS
cord-322966-o65fo853	29	26	in	in	IN
cord-322966-o65fo853	29	27	male	male	JJ
cord-322966-o65fo853	29	28	patients	patient	NNS
cord-322966-o65fo853	29	29	[	[	-LRB-
cord-322966-o65fo853	29	30	23	23	CD
cord-322966-o65fo853	29	31	]	]	-RRB-
cord-322966-o65fo853	29	32	.	.	.
cord-322966-o65fo853	30	1	There	there	EX
cord-322966-o65fo853	30	2	is	be	VBZ
cord-322966-o65fo853	30	3	debate	debate	NN
cord-322966-o65fo853	30	4	as	as	IN
cord-322966-o65fo853	30	5	to	to	IN
cord-322966-o65fo853	30	6	whether	whether	IN
cord-322966-o65fo853	30	7	the	the	DT
cord-322966-o65fo853	30	8	observed	observed	JJ
cord-322966-o65fo853	30	9	higher	high	JJR
cord-322966-o65fo853	30	10	levels	level	NNS
cord-322966-o65fo853	30	11	in	in	IN
cord-322966-o65fo853	30	12	male	male	JJ
cord-322966-o65fo853	30	13	,	,	,
cord-322966-o65fo853	30	14	hypertensive	hypertensive	JJ
cord-322966-o65fo853	30	15	,	,	,
cord-322966-o65fo853	30	16	and	and	CC
cord-322966-o65fo853	30	17	diabetic	diabetic	JJ
cord-322966-o65fo853	30	18	patients	patient	NNS
cord-322966-o65fo853	30	19	are	be	VBP
cord-322966-o65fo853	30	20	related	relate	VBN
cord-322966-o65fo853	30	21	to	to	IN
cord-322966-o65fo853	30	22	increased	increase	VBN
cord-322966-o65fo853	30	23	ACE-2	ACE-2	NNP
cord-322966-o65fo853	30	24	expression	expression	NN
cord-322966-o65fo853	30	25	as	as	IN
cord-322966-o65fo853	30	26	a	a	DT
cord-322966-o65fo853	30	27	compensatory	compensatory	JJ
cord-322966-o65fo853	30	28	mechanism	mechanism	NN
cord-322966-o65fo853	30	29	,	,	,
cord-322966-o65fo853	30	30	or	or	CC
cord-322966-o65fo853	30	31	whether	whether	IN
cord-322966-o65fo853	30	32	it	-PRON-	PRP
cord-322966-o65fo853	30	33	is	be	VBZ
cord-322966-o65fo853	30	34	due	due	JJ
cord-322966-o65fo853	30	35	to	to	IN
cord-322966-o65fo853	30	36	increased	increase	VBN
cord-322966-o65fo853	30	37	ACE-2	ACE-2	NNP
cord-322966-o65fo853	30	38	shedding	shed	VBG
cord-322966-o65fo853	30	39	,	,	,
cord-322966-o65fo853	30	40	limiting	limit	VBG
cord-322966-o65fo853	30	41	tissue	tissue	NN
cord-322966-o65fo853	30	42	ACE-2	ACE-2	NNP
cord-322966-o65fo853	30	43	activity	activity	NN
cord-322966-o65fo853	30	44	and	and	CC
cord-322966-o65fo853	30	45	causing	cause	VBG
cord-322966-o65fo853	30	46	excess	excess	JJ
cord-322966-o65fo853	30	47	tissue	tissue	NN
cord-322966-o65fo853	30	48	Ang	Ang	NNP
cord-322966-o65fo853	30	49	II	II	NNP
cord-322966-o65fo853	30	50	.	.	.
cord-322966-o65fo853	31	1	The	the	DT
cord-322966-o65fo853	31	2	role	role	NN
cord-322966-o65fo853	31	3	of	of	IN
cord-322966-o65fo853	31	4	circulating	circulate	VBG
cord-322966-o65fo853	31	5	,	,	,
cord-322966-o65fo853	31	6	versus	versus	IN
cord-322966-o65fo853	31	7	tissue	tissue	NN
cord-322966-o65fo853	31	8	,	,	,
cord-322966-o65fo853	31	9	ACE-2	ACE-2	NNP
cord-322966-o65fo853	31	10	levels	level	NNS
cord-322966-o65fo853	31	11	in	in	IN
cord-322966-o65fo853	31	12	susceptibility	susceptibility	NN
cord-322966-o65fo853	31	13	to	to	IN
cord-322966-o65fo853	31	14	COVID	covid	JJ
cord-322966-o65fo853	31	15	infection	infection	NN
cord-322966-o65fo853	31	16	is	be	VBZ
cord-322966-o65fo853	31	17	unclear	unclear	JJ
cord-322966-o65fo853	31	18	[	[	-LRB-
cord-322966-o65fo853	31	19	24	24	CD
cord-322966-o65fo853	31	20	]	]	-RRB-
cord-322966-o65fo853	31	21	.	.	.
cord-322966-o65fo853	32	1	In	in	IN
cord-322966-o65fo853	32	2	viral	viral	JJ
cord-322966-o65fo853	32	3	downregulation	downregulation	NN
cord-322966-o65fo853	32	4	of	of	IN
cord-322966-o65fo853	32	5	ACE-2	ACE-2	NNP
cord-322966-o65fo853	32	6	,	,	,
cord-322966-o65fo853	32	7	unopposed	unopposed	JJ
cord-322966-o65fo853	32	8	ACE	ACE	NNP
cord-322966-o65fo853	32	9	generates	generate	VBZ
cord-322966-o65fo853	32	10	high	high	JJ
cord-322966-o65fo853	32	11	Ang	Ang	NNP
cord-322966-o65fo853	32	12	II	II	NNP
cord-322966-o65fo853	32	13	causing	cause	VBG
cord-322966-o65fo853	32	14	increased	increase	VBN
cord-322966-o65fo853	32	15	BP	BP	NNP
cord-322966-o65fo853	32	16	,	,	,
cord-322966-o65fo853	32	17	vasoconstriction	vasoconstriction	NN
cord-322966-o65fo853	32	18	,	,	,
cord-322966-o65fo853	32	19	inflammation	inflammation	NN
cord-322966-o65fo853	32	20	and	and	CC
cord-322966-o65fo853	32	21	cell	cell	NN
cord-322966-o65fo853	32	22	damage	damage	NN
cord-322966-o65fo853	32	23	.	.	.
cord-322966-o65fo853	33	1	To	to	TO
cord-322966-o65fo853	33	2	exacerbate	exacerbate	VB
cord-322966-o65fo853	33	3	matters	matter	NNS
cord-322966-o65fo853	33	4	,	,	,
cord-322966-o65fo853	33	5	the	the	DT
cord-322966-o65fo853	33	6	active	active	JJ
cord-322966-o65fo853	33	7	metabolite	metabolite	NN
cord-322966-o65fo853	33	8	generated	generate	VBN
cord-322966-o65fo853	33	9	by	by	IN
cord-322966-o65fo853	33	10	ACE-2	ACE-2	NNP
cord-322966-o65fo853	33	11	,	,	,
cord-322966-o65fo853	33	12	Ang(1	Ang(1	NNP
cord-322966-o65fo853	33	13	-	-	HYPH
cord-322966-o65fo853	33	14	7	7	CD
cord-322966-o65fo853	33	15	)	)	-RRB-
cord-322966-o65fo853	33	16	,	,	,
cord-322966-o65fo853	33	17	can	can	MD
cord-322966-o65fo853	33	18	be	be	VB
cord-322966-o65fo853	33	19	broken	break	VBN
cord-322966-o65fo853	33	20	down	down	RP
cord-322966-o65fo853	33	21	by	by	IN
cord-322966-o65fo853	33	22	ACE	ace	NN
cord-322966-o65fo853	33	23	itself	-PRON-	PRP
cord-322966-o65fo853	33	24	,	,	,
cord-322966-o65fo853	33	25	accentuating	accentuate	VBG
cord-322966-o65fo853	33	26	the	the	DT
cord-322966-o65fo853	33	27	RAS	RAS	NNP
cord-322966-o65fo853	33	28	imbalance	imbalance	NN
cord-322966-o65fo853	33	29	caused	cause	VBN
cord-322966-o65fo853	33	30	by	by	IN
cord-322966-o65fo853	33	31	COVID-19	COVID-19	NNP
cord-322966-o65fo853	33	32	[	[	-LRB-
cord-322966-o65fo853	33	33	21	21	CD
cord-322966-o65fo853	33	34	]	]	-RRB-
cord-322966-o65fo853	34	1	(	(	-LRB-
cord-322966-o65fo853	34	2	Figure	figure	NN
cord-322966-o65fo853	34	3	1	1	CD
cord-322966-o65fo853	34	4	)	)	-RRB-
cord-322966-o65fo853	34	5	.	.	.
cord-322966-o65fo853	34	6	 	 	_SP
cord-322966-o65fo853	35	1	COVID-19	COVID-19	NNP
cord-322966-o65fo853	35	2	is	be	VBZ
cord-322966-o65fo853	35	3	highly	highly	RB
cord-322966-o65fo853	35	4	contagious	contagious	JJ
cord-322966-o65fo853	35	5	spreading	spread	VBG
cord-322966-o65fo853	35	6	from	from	IN
cord-322966-o65fo853	35	7	one	one	CD
cord-322966-o65fo853	35	8	province	province	NN
cord-322966-o65fo853	35	9	,	,	,
cord-322966-o65fo853	35	10	in	in	IN
cord-322966-o65fo853	35	11	December	December	NNP
cord-322966-o65fo853	35	12	2019	2019	CD
cord-322966-o65fo853	35	13	,	,	,
cord-322966-o65fo853	35	14	to	to	IN
cord-322966-o65fo853	35	15	the	the	DT
cord-322966-o65fo853	35	16	whole	whole	NN
cord-322966-o65fo853	35	17	of	of	IN
cord-322966-o65fo853	35	18	China	China	NNP
cord-322966-o65fo853	35	19	in	in	IN
cord-322966-o65fo853	35	20	30	30	CD
cord-322966-o65fo853	35	21	days	day	NNS
cord-322966-o65fo853	35	22	,	,	,
cord-322966-o65fo853	35	23	despite	despite	IN
cord-322966-o65fo853	35	24	extreme	extreme	JJ
cord-322966-o65fo853	35	25	shutdown	shutdown	NN
cord-322966-o65fo853	35	26	measures	measure	NNS
cord-322966-o65fo853	35	27	[	[	-LRB-
cord-322966-o65fo853	35	28	2	2	CD
cord-322966-o65fo853	35	29	]	]	-RRB-
cord-322966-o65fo853	35	30	.	.	.
cord-322966-o65fo853	36	1	By	by	IN
cord-322966-o65fo853	36	2	May	May	NNP
cord-322966-o65fo853	36	3	2020	2020	CD
cord-322966-o65fo853	36	4	,	,	,
cord-322966-o65fo853	36	5	the	the	DT
cord-322966-o65fo853	36	6	disease	disease	NN
cord-322966-o65fo853	36	7	has	have	VBZ
cord-322966-o65fo853	36	8	infected	infect	VBN
cord-322966-o65fo853	36	9	3,392,718	3,392,718	CD
cord-322966-o65fo853	36	10	people	people	NNS
cord-322966-o65fo853	36	11	with	with	IN
cord-322966-o65fo853	36	12	239,178	239,178	CD
cord-322966-o65fo853	36	13	deaths	death	NNS
cord-322966-o65fo853	36	14	worldwide	worldwide	RB
cord-322966-o65fo853	36	15	[	[	-LRB-
cord-322966-o65fo853	36	16	9	9	CD
cord-322966-o65fo853	36	17	]	]	-RRB-
cord-322966-o65fo853	36	18	and	and	CC
cord-322966-o65fo853	36	19	is	be	VBZ
cord-322966-o65fo853	36	20	causing	cause	VBG
cord-322966-o65fo853	36	21	enormous	enormous	JJ
cord-322966-o65fo853	36	22	global	global	JJ
cord-322966-o65fo853	36	23	economic	economic	JJ
cord-322966-o65fo853	36	24	and	and	CC
cord-322966-o65fo853	36	25	social	social	JJ
cord-322966-o65fo853	36	26	impacts	impact	NNS
cord-322966-o65fo853	36	27	.	.	.
cord-322966-o65fo853	37	1	Epidemiology	epidemiology	NN
cord-322966-o65fo853	37	2	for	for	IN
cord-322966-o65fo853	37	3	72,314	72,314	CD
cord-322966-o65fo853	37	4	confirmed	confirm	VBD
cord-322966-o65fo853	37	5	,	,	,
cord-322966-o65fo853	37	6	suspected	suspect	VBN
cord-322966-o65fo853	37	7	and	and	CC
cord-322966-o65fo853	37	8	asymptomatic	asymptomatic	JJ
cord-322966-o65fo853	37	9	cases	case	NNS
cord-322966-o65fo853	37	10	in	in	IN
cord-322966-o65fo853	37	11	China	China	NNP
cord-322966-o65fo853	37	12	suggested	suggest	VBD
cord-322966-o65fo853	37	13	mild	mild	JJ
cord-322966-o65fo853	37	14	disease	disease	NN
cord-322966-o65fo853	37	15	in	in	IN
cord-322966-o65fo853	37	16	81	81	CD
cord-322966-o65fo853	37	17	%	%	NN
cord-322966-o65fo853	37	18	,	,	,
cord-322966-o65fo853	37	19	with	with	IN
cord-322966-o65fo853	37	20	2.3	2.3	CD
cord-322966-o65fo853	37	21	%	%	NN
cord-322966-o65fo853	37	22	fatality	fatality	NN
cord-322966-o65fo853	37	23	overall	overall	JJ
cord-322966-o65fo853	37	24	[	[	-LRB-
cord-322966-o65fo853	37	25	2	2	CD
cord-322966-o65fo853	37	26	]	]	-RRB-
cord-322966-o65fo853	37	27	.	.	.
cord-322966-o65fo853	38	1	Early	early	JJ
cord-322966-o65fo853	38	2	mortality	mortality	NN
cord-322966-o65fo853	38	3	figures	figure	NNS
cord-322966-o65fo853	38	4	in	in	IN
cord-322966-o65fo853	38	5	different	different	JJ
cord-322966-o65fo853	38	6	countries	country	NNS
cord-322966-o65fo853	38	7	have	have	VBP
cord-322966-o65fo853	38	8	shown	show	VBN
cord-322966-o65fo853	38	9	striking	strike	VBG
cord-322966-o65fo853	38	10	differences	difference	NNS
cord-322966-o65fo853	38	11	,	,	,
cord-322966-o65fo853	38	12	with	with	IN
cord-322966-o65fo853	38	13	greater	great	JJR
cord-322966-o65fo853	38	14	mortality	mortality	NN
cord-322966-o65fo853	38	15	in	in	IN
cord-322966-o65fo853	38	16	Europe	Europe	NNP
cord-322966-o65fo853	38	17	,	,	,
cord-322966-o65fo853	38	18	compared	compare	VBN
cord-322966-o65fo853	38	19	to	to	IN
cord-322966-o65fo853	38	20	Asian	asian	JJ
cord-322966-o65fo853	38	21	countries	country	NNS
cord-322966-o65fo853	38	22	[	[	-LRB-
cord-322966-o65fo853	38	23	9	9	CD
cord-322966-o65fo853	38	24	]	]	-RRB-
cord-322966-o65fo853	38	25	,	,	,
cord-322966-o65fo853	38	26	which	which	WDT
cord-322966-o65fo853	38	27	may	may	MD
cord-322966-o65fo853	38	28	relate	relate	VB
cord-322966-o65fo853	38	29	to	to	IN
cord-322966-o65fo853	38	30	fundamental	fundamental	JJ
cord-322966-o65fo853	38	31	differences	difference	NNS
cord-322966-o65fo853	38	32	in	in	IN
cord-322966-o65fo853	38	33	racial	racial	JJ
cord-322966-o65fo853	38	34	ACE	ace	NN
cord-322966-o65fo853	38	35	and	and	CC
cord-322966-o65fo853	38	36	ACE-2	ACE-2	NNP
cord-322966-o65fo853	38	37	polymorphisms	polymorphism	NNS
cord-322966-o65fo853	38	38	,	,	,
cord-322966-o65fo853	38	39	impacting	impact	VBG
cord-322966-o65fo853	38	40	both	both	DT
cord-322966-o65fo853	38	41	susceptibility	susceptibility	NN
cord-322966-o65fo853	38	42	to	to	IN
cord-322966-o65fo853	38	43	the	the	DT
cord-322966-o65fo853	38	44	disease	disease	NN
cord-322966-o65fo853	38	45	and	and	CC
cord-322966-o65fo853	38	46	subsequent	subsequent	JJ
cord-322966-o65fo853	38	47	pathological	pathological	JJ
cord-322966-o65fo853	38	48	severity	severity	NN
cord-322966-o65fo853	38	49	.	.	.
cord-322966-o65fo853	39	1	Population	population	NN
cord-322966-o65fo853	39	2	demographics	demographic	NNS
cord-322966-o65fo853	39	3	clearly	clearly	RB
cord-322966-o65fo853	39	4	play	play	VBP
cord-322966-o65fo853	39	5	a	a	DT
cord-322966-o65fo853	39	6	role	role	NN
cord-322966-o65fo853	39	7	with	with	IN
cord-322966-o65fo853	39	8	elderly	elderly	JJ
cord-322966-o65fo853	39	9	patients	patient	NNS
cord-322966-o65fo853	39	10	at	at	IN
cord-322966-o65fo853	39	11	greatest	great	JJS
cord-322966-o65fo853	39	12	risk	risk	NN
cord-322966-o65fo853	39	13	of	of	IN
cord-322966-o65fo853	39	14	severe	severe	JJ
cord-322966-o65fo853	39	15	disease	disease	NN
cord-322966-o65fo853	39	16	and	and	CC
cord-322966-o65fo853	39	17	death	death	NN
cord-322966-o65fo853	39	18	.	.	.
cord-322966-o65fo853	40	1	Key	key	JJ
cord-322966-o65fo853	40	2	differences	difference	NNS
cord-322966-o65fo853	40	3	in	in	IN
cord-322966-o65fo853	40	4	the	the	DT
cord-322966-o65fo853	40	5	speed	speed	NN
cord-322966-o65fo853	40	6	of	of	IN
cord-322966-o65fo853	40	7	government	government	NN
cord-322966-o65fo853	40	8	actions	action	NNS
cord-322966-o65fo853	40	9	to	to	TO
cord-322966-o65fo853	40	10	implement	implement	VB
cord-322966-o65fo853	40	11	extensive	extensive	JJ
cord-322966-o65fo853	40	12	public	public	JJ
cord-322966-o65fo853	40	13	health	health	NN
cord-322966-o65fo853	40	14	measures	measure	NNS
cord-322966-o65fo853	40	15	,	,	,
cord-322966-o65fo853	40	16	as	as	IN
cord-322966-o65fo853	40	17	recommended	recommend	VBN
cord-322966-o65fo853	40	18	by	by	IN
cord-322966-o65fo853	40	19	the	the	DT
cord-322966-o65fo853	40	20	World	World	NNP
cord-322966-o65fo853	40	21	Health	Health	NNP
cord-322966-o65fo853	40	22	Organization	Organization	NNP
cord-322966-o65fo853	40	23	(	(	-LRB-
cord-322966-o65fo853	40	24	WHO	who	WP
cord-322966-o65fo853	40	25	)	)	-RRB-
cord-322966-o65fo853	40	26	,	,	,
cord-322966-o65fo853	40	27	have	have	VBP
cord-322966-o65fo853	40	28	also	also	RB
cord-322966-o65fo853	40	29	impacted	impact	VBN
cord-322966-o65fo853	40	30	mortality	mortality	NN
cord-322966-o65fo853	40	31	rates	rate	NNS
cord-322966-o65fo853	40	32	as	as	IN
cord-322966-o65fo853	40	33	hospitals	hospital	NNS
cord-322966-o65fo853	40	34	in	in	IN
cord-322966-o65fo853	40	35	some	some	DT
cord-322966-o65fo853	40	36	countries	country	NNS
cord-322966-o65fo853	40	37	have	have	VBP
cord-322966-o65fo853	40	38	been	be	VBN
cord-322966-o65fo853	40	39	overwhelmed	overwhelm	VBN
cord-322966-o65fo853	40	40	by	by	IN
cord-322966-o65fo853	40	41	a	a	DT
cord-322966-o65fo853	40	42	rapid	rapid	JJ
cord-322966-o65fo853	40	43	rise	rise	NN
cord-322966-o65fo853	40	44	in	in	IN
cord-322966-o65fo853	40	45	cases	case	NNS
cord-322966-o65fo853	40	46	.	.	.
cord-322966-o65fo853	41	1	Why	why	WRB
cord-322966-o65fo853	41	2	do	do	VBP
cord-322966-o65fo853	41	3	81	81	CD
cord-322966-o65fo853	41	4	%	%	NN
cord-322966-o65fo853	41	5	of	of	IN
cord-322966-o65fo853	41	6	cases	case	NNS
cord-322966-o65fo853	41	7	have	have	VBP
cord-322966-o65fo853	41	8	a	a	DT
cord-322966-o65fo853	41	9	mild	mild	JJ
cord-322966-o65fo853	41	10	disease	disease	NN
cord-322966-o65fo853	41	11	and	and	CC
cord-322966-o65fo853	41	12	yet	yet	RB
cord-322966-o65fo853	41	13	19	19	CD
cord-322966-o65fo853	41	14	%	%	NN
cord-322966-o65fo853	41	15	have	have	VBP
cord-322966-o65fo853	41	16	a	a	DT
cord-322966-o65fo853	41	17	more	more	RBR
cord-322966-o65fo853	41	18	severe	severe	JJ
cord-322966-o65fo853	41	19	disease	disease	NN
cord-322966-o65fo853	41	20	?	?	.
cord-322966-o65fo853	42	1	The	the	DT
cord-322966-o65fo853	42	2	Chinese	Chinese	NNP
cord-322966-o65fo853	42	3	Center	Center	NNP
cord-322966-o65fo853	42	4	for	for	IN
cord-322966-o65fo853	42	5	Disease	Disease	NNP
cord-322966-o65fo853	42	6	Control	Control	NNP
cord-322966-o65fo853	42	7	and	and	CC
cord-322966-o65fo853	42	8	Prevention	Prevention	NNP
cord-322966-o65fo853	42	9	(	(	-LRB-
cord-322966-o65fo853	42	10	CCDC	CCDC	NNP
cord-322966-o65fo853	42	11	)	)	-RRB-
cord-322966-o65fo853	42	12	epidemiology	epidemiology	NN
cord-322966-o65fo853	42	13	showed	show	VBD
cord-322966-o65fo853	42	14	that	that	IN
cord-322966-o65fo853	42	15	there	there	EX
cord-322966-o65fo853	42	16	was	be	VBD
cord-322966-o65fo853	42	17	an	an	DT
cord-322966-o65fo853	42	18	overall	overall	JJ
cord-322966-o65fo853	42	19	mortality	mortality	NN
cord-322966-o65fo853	42	20	of	of	IN
cord-322966-o65fo853	42	21	2.3	2.3	CD
cord-322966-o65fo853	42	22	%	%	NN
cord-322966-o65fo853	42	23	[	[	-LRB-
cord-322966-o65fo853	42	24	2	2	CD
cord-322966-o65fo853	42	25	]	]	-RRB-
cord-322966-o65fo853	42	26	.	.	.
cord-322966-o65fo853	43	1	The	the	DT
cord-322966-o65fo853	43	2	death	death	NN
cord-322966-o65fo853	43	3	rate	rate	NN
cord-322966-o65fo853	43	4	increased	increase	VBD
cord-322966-o65fo853	43	5	with	with	IN
cord-322966-o65fo853	43	6	age	age	NN
cord-322966-o65fo853	43	7	and	and	CC
cord-322966-o65fo853	43	8	with	with	IN
cord-322966-o65fo853	43	9	co	co	NNS
cord-322966-o65fo853	43	10	-	-	NNS
cord-322966-o65fo853	43	11	morbidities	morbidity	NNS
cord-322966-o65fo853	43	12	,	,	,
cord-322966-o65fo853	43	13	particularly	particularly	RB
cord-322966-o65fo853	43	14	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	43	15	disease	disease	NN
cord-322966-o65fo853	43	16	(	(	-LRB-
cord-322966-o65fo853	43	17	13.2	13.2	CD
cord-322966-o65fo853	43	18	%	%	NN
cord-322966-o65fo853	43	19	)	)	-RRB-
cord-322966-o65fo853	43	20	,	,	,
cord-322966-o65fo853	43	21	diabetes	diabetes	NN
cord-322966-o65fo853	43	22	(	(	-LRB-
cord-322966-o65fo853	43	23	9.2	9.2	CD
cord-322966-o65fo853	43	24	%	%	NN
cord-322966-o65fo853	43	25	)	)	-RRB-
cord-322966-o65fo853	43	26	and	and	CC
cord-322966-o65fo853	43	27	hypertension	hypertension	NN
cord-322966-o65fo853	43	28	(	(	-LRB-
cord-322966-o65fo853	43	29	8.4	8.4	CD
cord-322966-o65fo853	43	30	%	%	NN
cord-322966-o65fo853	43	31	)	)	-RRB-
cord-322966-o65fo853	43	32	,	,	,
cord-322966-o65fo853	43	33	all	all	PDT
cord-322966-o65fo853	43	34	the	the	DT
cord-322966-o65fo853	43	35	risk	risk	NN
cord-322966-o65fo853	43	36	factors	factor	NNS
cord-322966-o65fo853	43	37	typically	typically	RB
cord-322966-o65fo853	43	38	seen	see	VBN
cord-322966-o65fo853	43	39	in	in	IN
cord-322966-o65fo853	43	40	those	those	DT
cord-322966-o65fo853	43	41	with	with	IN
cord-322966-o65fo853	43	42	"	"	``
cord-322966-o65fo853	43	43	metabolic	metabolic	JJ
cord-322966-o65fo853	43	44	syndrome	syndrome	NN
cord-322966-o65fo853	43	45	"	"	''
cord-322966-o65fo853	43	46	.	.	.
cord-322966-o65fo853	44	1	Whilst	whilst	IN
cord-322966-o65fo853	44	2	it	-PRON-	PRP
cord-322966-o65fo853	44	3	is	be	VBZ
cord-322966-o65fo853	44	4	clear	clear	JJ
cord-322966-o65fo853	44	5	that	that	IN
cord-322966-o65fo853	44	6	co	co	NNS
cord-322966-o65fo853	44	7	-	-	NNS
cord-322966-o65fo853	44	8	morbidities	morbidity	NNS
cord-322966-o65fo853	44	9	and	and	CC
cord-322966-o65fo853	44	10	age	age	NN
cord-322966-o65fo853	44	11	increase	increase	NN
cord-322966-o65fo853	44	12	mortality	mortality	NN
cord-322966-o65fo853	44	13	,	,	,
cord-322966-o65fo853	44	14	what	what	WP
cord-322966-o65fo853	44	15	is	be	VBZ
cord-322966-o65fo853	44	16	not	not	RB
cord-322966-o65fo853	44	17	clear	clear	JJ
cord-322966-o65fo853	44	18	is	be	VBZ
cord-322966-o65fo853	44	19	whether	whether	IN
cord-322966-o65fo853	44	20	this	this	DT
cord-322966-o65fo853	44	21	excess	excess	NN
cord-322966-o65fo853	44	22	is	be	VBZ
cord-322966-o65fo853	44	23	due	due	JJ
cord-322966-o65fo853	44	24	to	to	IN
cord-322966-o65fo853	44	25	the	the	DT
cord-322966-o65fo853	44	26	impact	impact	NN
cord-322966-o65fo853	44	27	of	of	IN
cord-322966-o65fo853	44	28	the	the	DT
cord-322966-o65fo853	44	29	co	co	JJ
cord-322966-o65fo853	44	30	-	-	JJ
cord-322966-o65fo853	44	31	morbid	morbid	JJ
cord-322966-o65fo853	44	32	conditions	condition	NNS
cord-322966-o65fo853	44	33	on	on	IN
cord-322966-o65fo853	44	34	host	host	JJ
cord-322966-o65fo853	44	35	inflammatory	inflammatory	JJ
cord-322966-o65fo853	44	36	response	response	NN
cord-322966-o65fo853	44	37	alone	alone	RB
cord-322966-o65fo853	44	38	,	,	,
cord-322966-o65fo853	44	39	or	or	CC
cord-322966-o65fo853	44	40	to	to	IN
cord-322966-o65fo853	44	41	the	the	DT
cord-322966-o65fo853	44	42	impact	impact	NN
cord-322966-o65fo853	44	43	of	of	IN
cord-322966-o65fo853	44	44	a	a	DT
cord-322966-o65fo853	44	45	treatment	treatment	NN
cord-322966-o65fo853	44	46	some	some	DT
cord-322966-o65fo853	44	47	of	of	IN
cord-322966-o65fo853	44	48	this	this	DT
cord-322966-o65fo853	44	49	patient	patient	NN
cord-322966-o65fo853	44	50	group	group	NN
cord-322966-o65fo853	44	51	is	be	VBZ
cord-322966-o65fo853	44	52	taking	take	VBG
cord-322966-o65fo853	44	53	[	[	-LRB-
cord-322966-o65fo853	44	54	25	25	CD
cord-322966-o65fo853	44	55	]	]	-RRB-
cord-322966-o65fo853	44	56	.	.	.
cord-322966-o65fo853	45	1	Since	since	IN
cord-322966-o65fo853	45	2	the	the	DT
cord-322966-o65fo853	45	3	RAS	RAS	NNP
cord-322966-o65fo853	45	4	system	system	NN
cord-322966-o65fo853	45	5	is	be	VBZ
cord-322966-o65fo853	45	6	fundamentally	fundamentally	RB
cord-322966-o65fo853	45	7	involved	involve	VBN
cord-322966-o65fo853	45	8	in	in	IN
cord-322966-o65fo853	45	9	COVID-19	covid-19	JJ
cord-322966-o65fo853	45	10	pathogenesis	pathogenesis	NN
cord-322966-o65fo853	45	11	,	,	,
cord-322966-o65fo853	45	12	there	there	EX
cord-322966-o65fo853	45	13	was	be	VBD
cord-322966-o65fo853	45	14	great	great	JJ
cord-322966-o65fo853	45	15	speculation	speculation	NN
cord-322966-o65fo853	45	16	that	that	IN
cord-322966-o65fo853	45	17	drugs	drug	NNS
cord-322966-o65fo853	45	18	widely	widely	RB
cord-322966-o65fo853	45	19	used	use	VBN
cord-322966-o65fo853	45	20	in	in	IN
cord-322966-o65fo853	45	21	hypertension	hypertension	NN
cord-322966-o65fo853	45	22	and	and	CC
cord-322966-o65fo853	45	23	heart	heart	NN
cord-322966-o65fo853	45	24	failure	failure	NN
cord-322966-o65fo853	45	25	treatment	treatment	NN
cord-322966-o65fo853	45	26	,	,	,
cord-322966-o65fo853	45	27	acting	act	VBG
cord-322966-o65fo853	45	28	on	on	IN
cord-322966-o65fo853	45	29	the	the	DT
cord-322966-o65fo853	45	30	RAS	RAS	NNP
cord-322966-o65fo853	45	31	,	,	,
cord-322966-o65fo853	45	32	may	may	MD
cord-322966-o65fo853	45	33	impact	impact	VB
cord-322966-o65fo853	45	34	disease	disease	NN
cord-322966-o65fo853	45	35	severity	severity	NN
cord-322966-o65fo853	45	36	,	,	,
cord-322966-o65fo853	45	37	with	with	IN
cord-322966-o65fo853	45	38	some	some	DT
cord-322966-o65fo853	45	39	suggesting	suggest	VBG
cord-322966-o65fo853	45	40	a	a	DT
cord-322966-o65fo853	45	41	protective	protective	JJ
cord-322966-o65fo853	45	42	effect	effect	NN
cord-322966-o65fo853	45	43	[	[	-LRB-
cord-322966-o65fo853	45	44	15	15	CD
cord-322966-o65fo853	45	45	,	,	,
cord-322966-o65fo853	45	46	16	16	CD
cord-322966-o65fo853	45	47	]	]	-RRB-
cord-322966-o65fo853	45	48	and	and	CC
cord-322966-o65fo853	45	49	others	other	NNS
cord-322966-o65fo853	45	50	concerned	concerned	JJ
cord-322966-o65fo853	45	51	about	about	IN
cord-322966-o65fo853	45	52	potential	potential	JJ
cord-322966-o65fo853	45	53	harm	harm	NN
cord-322966-o65fo853	45	54	[	[	-LRB-
cord-322966-o65fo853	45	55	24	24	CD
cord-322966-o65fo853	45	56	]	]	-RRB-
cord-322966-o65fo853	45	57	.	.	.
cord-322966-o65fo853	46	1	These	these	DT
cord-322966-o65fo853	46	2	drugs	drug	NNS
cord-322966-o65fo853	46	3	include	include	VBP
cord-322966-o65fo853	46	4	ARBs	arb	NNS
cord-322966-o65fo853	46	5	,	,	,
cord-322966-o65fo853	46	6	ACEIs	acei	NNS
cord-322966-o65fo853	46	7	and	and	CC
cord-322966-o65fo853	46	8	the	the	DT
cord-322966-o65fo853	46	9	combination	combination	NN
cord-322966-o65fo853	46	10	drug	drug	NN
cord-322966-o65fo853	46	11	valsartan	valsartan	NNP
cord-322966-o65fo853	46	12	/	/	SYM
cord-322966-o65fo853	46	13	sacubitril	sacubitril	NNP
cord-322966-o65fo853	46	14	(	(	-LRB-
cord-322966-o65fo853	46	15	Entresto	Entresto	NNP
cord-322966-o65fo853	46	16	)	)	-RRB-
cord-322966-o65fo853	46	17	which	which	WDT
cord-322966-o65fo853	46	18	combines	combine	VBZ
cord-322966-o65fo853	46	19	an	an	DT
cord-322966-o65fo853	46	20	ARB	arb	NN
cord-322966-o65fo853	46	21	with	with	IN
cord-322966-o65fo853	46	22	a	a	DT
cord-322966-o65fo853	46	23	neprilysin	neprilysin	JJ
cord-322966-o65fo853	46	24	inhibitor	inhibitor	NN
cord-322966-o65fo853	46	25	(	(	-LRB-
cord-322966-o65fo853	46	26	also	also	RB
cord-322966-o65fo853	46	27	known	know	VBN
cord-322966-o65fo853	46	28	as	as	IN
cord-322966-o65fo853	46	29	an	an	DT
cord-322966-o65fo853	46	30	angiotensin	angiotensin	NN
cord-322966-o65fo853	46	31	receptor	receptor	NN
cord-322966-o65fo853	46	32	-	-	HYPH
cord-322966-o65fo853	46	33	neprilysin	neprilysin	NN
cord-322966-o65fo853	46	34	inhibitor	inhibitor	NN
cord-322966-o65fo853	46	35	[	[	-LRB-
cord-322966-o65fo853	46	36	ARNI	ARNI	NNP
cord-322966-o65fo853	46	37	]	]	-RRB-
cord-322966-o65fo853	46	38	)	)	-RRB-
cord-322966-o65fo853	46	39	.	.	.
cord-322966-o65fo853	47	1	Whilst	whilst	IN
cord-322966-o65fo853	47	2	there	there	EX
cord-322966-o65fo853	47	3	is	be	VBZ
cord-322966-o65fo853	47	4	evidence	evidence	NN
cord-322966-o65fo853	47	5	that	that	IN
cord-322966-o65fo853	47	6	ACEI	ACEI	NNP
cord-322966-o65fo853	47	7	and	and	CC
cord-322966-o65fo853	47	8	ARB	ARB	NNP
cord-322966-o65fo853	47	9	treatment	treatment	NN
cord-322966-o65fo853	47	10	may	may	MD
cord-322966-o65fo853	47	11	increase	increase	VB
cord-322966-o65fo853	47	12	expression	expression	NN
cord-322966-o65fo853	47	13	of	of	IN
cord-322966-o65fo853	47	14	ACE-2	ACE-2	NNP
cord-322966-o65fo853	47	15	in	in	IN
cord-322966-o65fo853	47	16	some	some	DT
cord-322966-o65fo853	47	17	tissues	tissue	NNS
cord-322966-o65fo853	47	18	in	in	IN
cord-322966-o65fo853	47	19	animal	animal	NN
cord-322966-o65fo853	47	20	models	model	NNS
cord-322966-o65fo853	47	21	,	,	,
cord-322966-o65fo853	47	22	data	datum	NNS
cord-322966-o65fo853	47	23	supporting	support	VBG
cord-322966-o65fo853	47	24	or	or	CC
cord-322966-o65fo853	47	25	quantifying	quantify	VBG
cord-322966-o65fo853	47	26	this	this	DT
cord-322966-o65fo853	47	27	effect	effect	NN
cord-322966-o65fo853	47	28	in	in	IN
cord-322966-o65fo853	47	29	human	human	JJ
cord-322966-o65fo853	47	30	subjects	subject	NNS
cord-322966-o65fo853	47	31	at	at	IN
cord-322966-o65fo853	47	32	clinical	clinical	JJ
cord-322966-o65fo853	47	33	doses	dose	NNS
cord-322966-o65fo853	47	34	of	of	IN
cord-322966-o65fo853	47	35	RAS	RAS	NNP
cord-322966-o65fo853	47	36	medications	medication	NNS
cord-322966-o65fo853	47	37	is	be	VBZ
cord-322966-o65fo853	47	38	lacking	lack	VBG
cord-322966-o65fo853	47	39	[	[	-LRB-
cord-322966-o65fo853	47	40	24	24	CD
cord-322966-o65fo853	47	41	]	]	-RRB-
cord-322966-o65fo853	47	42	.	.	.
cord-322966-o65fo853	48	1	Hence	hence	RB
cord-322966-o65fo853	48	2	the	the	DT
cord-322966-o65fo853	48	3	relevance	relevance	NN
cord-322966-o65fo853	48	4	of	of	IN
cord-322966-o65fo853	48	5	possible	possible	JJ
cord-322966-o65fo853	48	6	medication	medication	NN
cord-322966-o65fo853	48	7	-	-	HYPH
cord-322966-o65fo853	48	8	induced	induce	VBN
cord-322966-o65fo853	48	9	alteration	alteration	NN
cord-322966-o65fo853	48	10	in	in	IN
cord-322966-o65fo853	48	11	ACE-2	ACE-2	NNP
cord-322966-o65fo853	48	12	levels	level	NNS
cord-322966-o65fo853	48	13	,	,	,
cord-322966-o65fo853	48	14	over	over	RB
cord-322966-o65fo853	48	15	and	and	CC
cord-322966-o65fo853	48	16	above	above	IN
cord-322966-o65fo853	48	17	the	the	DT
cord-322966-o65fo853	48	18	welldescribed	welldescribed	JJ
cord-322966-o65fo853	48	19	significant	significant	JJ
cord-322966-o65fo853	48	20	differences	difference	NNS
cord-322966-o65fo853	48	21	in	in	IN
cord-322966-o65fo853	48	22	circulating	circulate	VBG
cord-322966-o65fo853	48	23	levels	level	NNS
cord-322966-o65fo853	48	24	of	of	IN
cord-322966-o65fo853	48	25	ACE-2	ACE-2	NNP
cord-322966-o65fo853	48	26	in	in	IN
cord-322966-o65fo853	48	27	advanced	advanced	JJ
cord-322966-o65fo853	48	28	heart	heart	NN
cord-322966-o65fo853	48	29	failure	failure	NN
cord-322966-o65fo853	48	30	,	,	,
cord-322966-o65fo853	48	31	hypertension	hypertension	NN
cord-322966-o65fo853	48	32	,	,	,
cord-322966-o65fo853	48	33	males	male	NNS
cord-322966-o65fo853	48	34	and	and	CC
cord-322966-o65fo853	48	35	diabetics	diabetic	NNS
cord-322966-o65fo853	48	36	,	,	,
cord-322966-o65fo853	48	37	and	and	CC
cord-322966-o65fo853	48	38	the	the	DT
cord-322966-o65fo853	48	39	implications	implication	NNS
cord-322966-o65fo853	48	40	for	for	IN
cord-322966-o65fo853	48	41	COVID-19	covid-19	JJ
cord-322966-o65fo853	48	42	severity	severity	NN
cord-322966-o65fo853	48	43	,	,	,
cord-322966-o65fo853	48	44	is	be	VBZ
cord-322966-o65fo853	48	45	unclear	unclear	JJ
cord-322966-o65fo853	48	46	[	[	-LRB-
cord-322966-o65fo853	48	47	22	22	CD
cord-322966-o65fo853	48	48	,	,	,
cord-322966-o65fo853	48	49	23	23	CD
cord-322966-o65fo853	48	50	,	,	,
cord-322966-o65fo853	48	51	25	25	CD
cord-322966-o65fo853	48	52	]	]	-RRB-
cord-322966-o65fo853	48	53	.	.	.
cord-322966-o65fo853	49	1	Increased	increase	VBN
cord-322966-o65fo853	49	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	49	3	was	be	VBD
cord-322966-o65fo853	49	4	speculated	speculate	VBN
cord-322966-o65fo853	49	5	to	to	TO
cord-322966-o65fo853	49	6	increase	increase	VB
cord-322966-o65fo853	49	7	susceptibility	susceptibility	NN
cord-322966-o65fo853	49	8	to	to	IN
cord-322966-o65fo853	49	9	COVID-19	covid-19	VB
cord-322966-o65fo853	49	10	by	by	IN
cord-322966-o65fo853	49	11	allowing	allow	VBG
cord-322966-o65fo853	49	12	more	more	JJR
cord-322966-o65fo853	49	13	virus	virus	NN
cord-322966-o65fo853	49	14	into	into	IN
cord-322966-o65fo853	49	15	cells	cell	NNS
cord-322966-o65fo853	49	16	which	which	WDT
cord-322966-o65fo853	49	17	,	,	,
cord-322966-o65fo853	49	18	in	in	IN
cord-322966-o65fo853	49	19	turn	turn	NN
cord-322966-o65fo853	49	20	,	,	,
cord-322966-o65fo853	49	21	may	may	MD
cord-322966-o65fo853	49	22	exacerbate	exacerbate	VB
cord-322966-o65fo853	49	23	disease	disease	NN
cord-322966-o65fo853	49	24	severity	severity	NN
cord-322966-o65fo853	49	25	.	.	.
cord-322966-o65fo853	50	1	The	the	DT
cord-322966-o65fo853	50	2	counter	counter	JJ
cord-322966-o65fo853	50	3	argument	argument	NN
cord-322966-o65fo853	50	4	is	be	VBZ
cord-322966-o65fo853	50	5	that	that	IN
cord-322966-o65fo853	50	6	,	,	,
cord-322966-o65fo853	50	7	once	once	RB
cord-322966-o65fo853	50	8	infected	infect	VBN
cord-322966-o65fo853	50	9	,	,	,
cord-322966-o65fo853	50	10	having	have	VBG
cord-322966-o65fo853	50	11	more	more	JJR
cord-322966-o65fo853	50	12	ACE-2	ACE-2	NNP
cord-322966-o65fo853	50	13	could	could	MD
cord-322966-o65fo853	50	14	be	be	VB
cord-322966-o65fo853	50	15	protective	protective	JJ
cord-322966-o65fo853	50	16	against	against	IN
cord-322966-o65fo853	50	17	viral	viral	JJ
cord-322966-o65fo853	50	18	attack	attack	NN
cord-322966-o65fo853	50	19	and	and	CC
cord-322966-o65fo853	50	20	downregulation	downregulation	NN
cord-322966-o65fo853	50	21	of	of	IN
cord-322966-o65fo853	50	22	the	the	DT
cord-322966-o65fo853	50	23	ACE-2	ACE-2	NNP
cord-322966-o65fo853	50	24	antiinflammatory	antiinflammatory	JJ
cord-322966-o65fo853	50	25	system	system	NN
cord-322966-o65fo853	50	26	[	[	-LRB-
cord-322966-o65fo853	50	27	26	26	CD
cord-322966-o65fo853	50	28	,	,	,
cord-322966-o65fo853	50	29	27	27	CD
cord-322966-o65fo853	50	30	]	]	-RRB-
cord-322966-o65fo853	50	31	.	.	.
cord-322966-o65fo853	51	1	Three	three	CD
cord-322966-o65fo853	51	2	(	(	-LRB-
cord-322966-o65fo853	51	3	3	3	CD
cord-322966-o65fo853	51	4	)	)	-RRB-
cord-322966-o65fo853	51	5	large	large	JJ
cord-322966-o65fo853	51	6	observational	observational	JJ
cord-322966-o65fo853	51	7	studies	study	NNS
cord-322966-o65fo853	51	8	reported	report	VBN
cord-322966-o65fo853	51	9	in	in	IN
cord-322966-o65fo853	51	10	the	the	DT
cord-322966-o65fo853	51	11	NEJM	NEJM	NNP
cord-322966-o65fo853	51	12	have	have	VBP
cord-322966-o65fo853	51	13	now	now	RB
cord-322966-o65fo853	51	14	examined	examine	VBN
cord-322966-o65fo853	51	15	this	this	DT
cord-322966-o65fo853	51	16	issue	issue	NN
cord-322966-o65fo853	51	17	and	and	CC
cord-322966-o65fo853	51	18	found	find	VBD
cord-322966-o65fo853	51	19	no	no	DT
cord-322966-o65fo853	51	20	evidence	evidence	NN
cord-322966-o65fo853	51	21	for	for	IN
cord-322966-o65fo853	51	22	increased	increase	VBN
cord-322966-o65fo853	51	23	risk	risk	NN
cord-322966-o65fo853	51	24	of	of	IN
cord-322966-o65fo853	51	25	adverse	adverse	JJ
cord-322966-o65fo853	51	26	outcomes	outcome	NNS
cord-322966-o65fo853	51	27	in	in	IN
cord-322966-o65fo853	51	28	COVID-19	covid-19	JJ
cord-322966-o65fo853	51	29	patients	patient	NNS
cord-322966-o65fo853	51	30	taking	take	VBG
cord-322966-o65fo853	51	31	ACEI	ACEI	NNP
cord-322966-o65fo853	51	32	or	or	CC
cord-322966-o65fo853	51	33	ARBs	arb	NNS
cord-322966-o65fo853	51	34	[	[	-LRB-
cord-322966-o65fo853	51	35	10	10	CD
cord-322966-o65fo853	51	36	,	,	,
cord-322966-o65fo853	51	37	13	13	CD
cord-322966-o65fo853	51	38	,	,	,
cord-322966-o65fo853	51	39	14	14	CD
cord-322966-o65fo853	51	40	]	]	-RRB-
cord-322966-o65fo853	51	41	adding	add	VBG
cord-322966-o65fo853	51	42	weight	weight	NN
cord-322966-o65fo853	51	43	to	to	IN
cord-322966-o65fo853	51	44	previously	previously	RB
cord-322966-o65fo853	51	45	reported	report	VBN
cord-322966-o65fo853	51	46	smaller	small	JJR
cord-322966-o65fo853	51	47	retrospective	retrospective	JJ
cord-322966-o65fo853	51	48	clinical	clinical	JJ
cord-322966-o65fo853	51	49	studies	study	NNS
cord-322966-o65fo853	51	50	[	[	-LRB-
cord-322966-o65fo853	51	51	28	28	CD
cord-322966-o65fo853	51	52	]	]	-RRB-
cord-322966-o65fo853	52	1	[	[	-LRB-
cord-322966-o65fo853	52	2	29	29	CD
cord-322966-o65fo853	52	3	]	]	-RRB-
cord-322966-o65fo853	53	1	[	[	-LRB-
cord-322966-o65fo853	53	2	30	30	CD
cord-322966-o65fo853	53	3	]	]	-RRB-
cord-322966-o65fo853	53	4	which	which	WDT
cord-322966-o65fo853	53	5	also	also	RB
cord-322966-o65fo853	53	6	showed	show	VBD
cord-322966-o65fo853	53	7	no	no	DT
cord-322966-o65fo853	53	8	excess	excess	JJ
cord-322966-o65fo853	53	9	mortality	mortality	NN
cord-322966-o65fo853	53	10	for	for	IN
cord-322966-o65fo853	53	11	ACEI	ACEI	NNP
cord-322966-o65fo853	53	12	/	/	SYM
cord-322966-o65fo853	53	13	ARBs	arb	NNS
cord-322966-o65fo853	53	14	.	.	.
cord-322966-o65fo853	54	1	Mehra	Mehra	NNP
cord-322966-o65fo853	54	2	et	et	NNP
cord-322966-o65fo853	54	3	al	al	NNP
cord-322966-o65fo853	54	4	.	.	.
cord-322966-o65fo853	55	1	[	[	-LRB-
cord-322966-o65fo853	55	2	10	10	CD
cord-322966-o65fo853	55	3	]	]	-RRB-
cord-322966-o65fo853	55	4	reported	report	VBN
cord-322966-o65fo853	55	5	data	datum	NNS
cord-322966-o65fo853	55	6	for	for	IN
cord-322966-o65fo853	55	7	8,910	8,910	CD
cord-322966-o65fo853	55	8	patients	patient	NNS
cord-322966-o65fo853	55	9	admitted	admit	VBN
cord-322966-o65fo853	55	10	with	with	IN
cord-322966-o65fo853	55	11	COVID-19	COVID-19	NNP
cord-322966-o65fo853	55	12	in	in	IN
cord-322966-o65fo853	55	13	169	169	CD
cord-322966-o65fo853	55	14	hospitals	hospital	NNS
cord-322966-o65fo853	55	15	in	in	IN
cord-322966-o65fo853	55	16	Europe	Europe	NNP
cord-322966-o65fo853	55	17	,	,	,
cord-322966-o65fo853	55	18	Asia	Asia	NNP
cord-322966-o65fo853	55	19	and	and	CC
cord-322966-o65fo853	55	20	North	North	NNP
cord-322966-o65fo853	55	21	America	America	NNP
cord-322966-o65fo853	55	22	,	,	,
cord-322966-o65fo853	55	23	and	and	CC
cord-322966-o65fo853	55	24	confirmed	confirm	VBD
cord-322966-o65fo853	55	25	that	that	IN
cord-322966-o65fo853	55	26	age	age	NN
cord-322966-o65fo853	55	27	,	,	,
cord-322966-o65fo853	55	28	coronary	coronary	JJ
cord-322966-o65fo853	55	29	disease	disease	NN
cord-322966-o65fo853	55	30	,	,	,
cord-322966-o65fo853	55	31	heart	heart	NN
cord-322966-o65fo853	55	32	failure	failure	NN
cord-322966-o65fo853	55	33	,	,	,
cord-322966-o65fo853	55	34	cardiac	cardiac	JJ
cord-322966-o65fo853	55	35	arrhythmia	arrhythmia	NN
cord-322966-o65fo853	55	36	,	,	,
cord-322966-o65fo853	55	37	chronic	chronic	JJ
cord-322966-o65fo853	55	38	obstructive	obstructive	JJ
cord-322966-o65fo853	55	39	pulmonary	pulmonary	JJ
cord-322966-o65fo853	55	40	disease	disease	NN
cord-322966-o65fo853	55	41	and	and	CC
cord-322966-o65fo853	55	42	current	current	JJ
cord-322966-o65fo853	55	43	smoking	smoking	NN
cord-322966-o65fo853	55	44	were	be	VBD
cord-322966-o65fo853	55	45	all	all	DT
cord-322966-o65fo853	55	46	associated	associate	VBN
cord-322966-o65fo853	55	47	with	with	IN
cord-322966-o65fo853	55	48	increased	increase	VBN
cord-322966-o65fo853	55	49	in	in	IN
cord-322966-o65fo853	55	50	-	-	HYPH
cord-322966-o65fo853	55	51	hospital	hospital	NN
cord-322966-o65fo853	55	52	mortality	mortality	NN
cord-322966-o65fo853	55	53	but	but	CC
cord-322966-o65fo853	56	1	there	there	EX
cord-322966-o65fo853	56	2	was	be	VBD
cord-322966-o65fo853	56	3	no	no	DT
cord-322966-o65fo853	56	4	increased	increase	VBN
cord-322966-o65fo853	56	5	risk	risk	NN
cord-322966-o65fo853	56	6	of	of	IN
cord-322966-o65fo853	56	7	mortality	mortality	NN
cord-322966-o65fo853	56	8	associated	associate	VBN
cord-322966-o65fo853	56	9	with	with	IN
cord-322966-o65fo853	56	10	risk	risk	NN
cord-322966-o65fo853	56	11	of	of	IN
cord-322966-o65fo853	56	12	ACEI	ACEI	NNP
cord-322966-o65fo853	56	13	or	or	CC
cord-322966-o65fo853	56	14	ARBs	arb	NNS
cord-322966-o65fo853	56	15	.	.	.
cord-322966-o65fo853	57	1	They	-PRON-	PRP
cord-322966-o65fo853	57	2	did	do	VBD
cord-322966-o65fo853	57	3	find	find	VB
cord-322966-o65fo853	57	4	that	that	IN
cord-322966-o65fo853	57	5	use	use	NN
cord-322966-o65fo853	57	6	of	of	IN
cord-322966-o65fo853	57	7	ACEI	ACEI	NNP
cord-322966-o65fo853	57	8	and	and	CC
cord-322966-o65fo853	57	9	statins	statin	NNS
cord-322966-o65fo853	57	10	was	be	VBD
cord-322966-o65fo853	57	11	more	more	RBR
cord-322966-o65fo853	57	12	common	common	JJ
cord-322966-o65fo853	57	13	in	in	IN
cord-322966-o65fo853	57	14	survivors	survivor	NNS
cord-322966-o65fo853	57	15	,	,	,
cord-322966-o65fo853	57	16	however	however	RB
cord-322966-o65fo853	57	17	this	this	DT
cord-322966-o65fo853	57	18	was	be	VBD
cord-322966-o65fo853	57	19	not	not	RB
cord-322966-o65fo853	57	20	randomised	randomised	JJ
cord-322966-o65fo853	57	21	data	datum	NNS
cord-322966-o65fo853	57	22	.	.	.
cord-322966-o65fo853	58	1	A	a	DT
cord-322966-o65fo853	58	2	multicentre	multicentre	JJ
cord-322966-o65fo853	58	3	Chinese	chinese	JJ
cord-322966-o65fo853	58	4	study	study	NN
cord-322966-o65fo853	58	5	of	of	IN
cord-322966-o65fo853	58	6	1,128	1,128	CD
cord-322966-o65fo853	58	7	hospitalised	hospitalise	VBN
cord-322966-o65fo853	58	8	patients	patient	NNS
cord-322966-o65fo853	58	9	with	with	IN
cord-322966-o65fo853	58	10	COVID-19	covid-19	JJ
cord-322966-o65fo853	58	11	and	and	CC
cord-322966-o65fo853	58	12	pre	pre	JJ
cord-322966-o65fo853	58	13	-	-	JJ
cord-322966-o65fo853	58	14	existing	existing	JJ
cord-322966-o65fo853	58	15	hypertension	hypertension	NN
cord-322966-o65fo853	58	16	showed	show	VBD
cord-322966-o65fo853	58	17	a	a	DT
cord-322966-o65fo853	58	18	death	death	NN
cord-322966-o65fo853	58	19	rate	rate	NN
cord-322966-o65fo853	58	20	of	of	IN
cord-322966-o65fo853	58	21	3.7	3.7	CD
cord-322966-o65fo853	58	22	%	%	NN
cord-322966-o65fo853	58	23	in	in	IN
cord-322966-o65fo853	58	24	those	those	DT
cord-322966-o65fo853	58	25	on	on	IN
cord-322966-o65fo853	58	26	ACEI	ACEI	NNP
cord-322966-o65fo853	58	27	or	or	CC
cord-322966-o65fo853	58	28	ARB	ARB	NNP
cord-322966-o65fo853	58	29	versus	versus	IN
cord-322966-o65fo853	58	30	9.8	9.8	CD
cord-322966-o65fo853	58	31	%	%	NN
cord-322966-o65fo853	58	32	in	in	IN
cord-322966-o65fo853	58	33	non	non	NNS
cord-322966-o65fo853	58	34	-	-	NNS
cord-322966-o65fo853	58	35	users	user	NNS
cord-322966-o65fo853	58	36	(	(	-LRB-
cord-322966-o65fo853	58	37	p=0.03	p=0.03	NN
cord-322966-o65fo853	58	38	)	)	-RRB-
cord-322966-o65fo853	58	39	.	.	.
cord-322966-o65fo853	59	1	The	the	DT
cord-322966-o65fo853	59	2	data	datum	NNS
cord-322966-o65fo853	59	3	was	be	VBD
cord-322966-o65fo853	59	4	observational	observational	JJ
cord-322966-o65fo853	59	5	and	and	CC
cord-322966-o65fo853	59	6	not	not	RB
cord-322966-o65fo853	59	7	randomised	randomised	JJ
cord-322966-o65fo853	59	8	,	,	,
cord-322966-o65fo853	59	9	but	but	CC
cord-322966-o65fo853	59	10	even	even	RB
cord-322966-o65fo853	59	11	after	after	IN
cord-322966-o65fo853	59	12	adjustment	adjustment	NN
cord-322966-o65fo853	59	13	for	for	IN
cord-322966-o65fo853	59	14	confounding	confound	VBG
cord-322966-o65fo853	59	15	variables	variable	NNS
cord-322966-o65fo853	59	16	a	a	DT
cord-322966-o65fo853	59	17	lower	low	JJR
cord-322966-o65fo853	59	18	mortality	mortality	NN
cord-322966-o65fo853	59	19	,	,	,
cord-322966-o65fo853	59	20	with	with	IN
cord-322966-o65fo853	59	21	a	a	DT
cord-322966-o65fo853	59	22	hazard	hazard	NN
cord-322966-o65fo853	59	23	ratio	ratio	NN
cord-322966-o65fo853	59	24	of	of	IN
cord-322966-o65fo853	59	25	0.37	0.37	CD
cord-322966-o65fo853	59	26	(	(	-LRB-
cord-322966-o65fo853	59	27	p=0.03	p=0.03	NNP
cord-322966-o65fo853	59	28	)	)	-RRB-
cord-322966-o65fo853	59	29	persisted	persist	VBD
cord-322966-o65fo853	59	30	for	for	IN
cord-322966-o65fo853	59	31	those	those	DT
cord-322966-o65fo853	59	32	receiving	receive	VBG
cord-322966-o65fo853	59	33	ACEI	ACEI	NNP
cord-322966-o65fo853	59	34	/	/	SYM
cord-322966-o65fo853	59	35	ARBs	arb	NNS
cord-322966-o65fo853	59	36	,	,	,
cord-322966-o65fo853	59	37	with	with	IN
cord-322966-o65fo853	59	38	a	a	DT
cord-322966-o65fo853	59	39	HR	hr	NN
cord-322966-o65fo853	59	40	of	of	IN
cord-322966-o65fo853	59	41	0.3	0.3	CD
cord-322966-o65fo853	59	42	(	(	-LRB-
cord-322966-o65fo853	59	43	p=0.03	p=0.03	NN
cord-322966-o65fo853	59	44	)	)	-RRB-
cord-322966-o65fo853	59	45	compared	compare	VBN
cord-322966-o65fo853	59	46	to	to	IN
cord-322966-o65fo853	59	47	use	use	NN
cord-322966-o65fo853	59	48	of	of	IN
cord-322966-o65fo853	59	49	other	other	JJ
cord-322966-o65fo853	59	50	antihypertensive	antihypertensive	JJ
cord-322966-o65fo853	59	51	agents	agent	NNS
cord-322966-o65fo853	59	52	[	[	-LRB-
cord-322966-o65fo853	59	53	28	28	CD
cord-322966-o65fo853	59	54	]	]	-RRB-
cord-322966-o65fo853	59	55	.	.	.
cord-322966-o65fo853	60	1	The	the	DT
cord-322966-o65fo853	60	2	study	study	NN
cord-322966-o65fo853	60	3	did	do	VBD
cord-322966-o65fo853	60	4	not	not	RB
cord-322966-o65fo853	60	5	separate	separate	VB
cord-322966-o65fo853	60	6	treatment	treatment	NN
cord-322966-o65fo853	60	7	with	with	IN
cord-322966-o65fo853	60	8	ARBs	arb	NNS
cord-322966-o65fo853	60	9	from	from	IN
cord-322966-o65fo853	60	10	ACEI	ACEI	NNP
cord-322966-o65fo853	60	11	[	[	-LRB-
cord-322966-o65fo853	60	12	29	29	CD
cord-322966-o65fo853	60	13	]	]	-RRB-
cord-322966-o65fo853	60	14	.	.	.
cord-322966-o65fo853	61	1	The	the	DT
cord-322966-o65fo853	61	2	answer	answer	NN
cord-322966-o65fo853	61	3	to	to	IN
cord-322966-o65fo853	61	4	observed	observed	JJ
cord-322966-o65fo853	61	5	differences	difference	NNS
cord-322966-o65fo853	61	6	in	in	IN
cord-322966-o65fo853	61	7	COVID-19	covid-19	JJ
cord-322966-o65fo853	61	8	death	death	NN
cord-322966-o65fo853	61	9	rates	rate	NNS
cord-322966-o65fo853	61	10	could	could	MD
cord-322966-o65fo853	61	11	lie	lie	VB
cord-322966-o65fo853	61	12	in	in	IN
cord-322966-o65fo853	61	13	key	key	JJ
cord-322966-o65fo853	61	14	differences	difference	NNS
cord-322966-o65fo853	61	15	in	in	IN
cord-322966-o65fo853	61	16	the	the	DT
cord-322966-o65fo853	61	17	ACE	ace	NN
cord-322966-o65fo853	61	18	:	:	:
cord-322966-o65fo853	61	19	ACE-2	ACE-2	NNP
cord-322966-o65fo853	61	20	system	system	NN
cord-322966-o65fo853	61	21	balance	balance	NN
cord-322966-o65fo853	61	22	related	relate	VBN
cord-322966-o65fo853	61	23	to	to	IN
cord-322966-o65fo853	61	24	age	age	NN
cord-322966-o65fo853	61	25	,	,	,
cord-322966-o65fo853	61	26	gender	gender	NN
cord-322966-o65fo853	61	27	and	and	CC
cord-322966-o65fo853	61	28	racial	racial	JJ
cord-322966-o65fo853	61	29	variation	variation	NN
cord-322966-o65fo853	61	30	in	in	IN
cord-322966-o65fo853	61	31	genetic	genetic	JJ
cord-322966-o65fo853	61	32	ACE	ace	NN
cord-322966-o65fo853	61	33	and	and	CC
cord-322966-o65fo853	61	34	ACE-2	ACE-2	NNP
cord-322966-o65fo853	61	35	polymorphisms	polymorphism	NNS
cord-322966-o65fo853	61	36	and	and	CC
cord-322966-o65fo853	61	37	environmental	environmental	JJ
cord-322966-o65fo853	61	38	factors	factor	NNS
cord-322966-o65fo853	61	39	influencing	influence	VBG
cord-322966-o65fo853	61	40	ACE-2	ACE-2	NNP
cord-322966-o65fo853	61	41	expression	expression	NN
cord-322966-o65fo853	61	42	[	[	-LRB-
cord-322966-o65fo853	61	43	6	6	CD
cord-322966-o65fo853	61	44	,	,	,
cord-322966-o65fo853	61	45	31	31	CD
cord-322966-o65fo853	61	46	)	)	-RRB-
cord-322966-o65fo853	61	47	.	.	.
cord-322966-o65fo853	62	1	There	there	EX
cord-322966-o65fo853	62	2	are	be	VBP
cord-322966-o65fo853	62	3	ACE	ace	NN
cord-322966-o65fo853	62	4	gene	gene	NN
cord-322966-o65fo853	62	5	polymorphisms	polymorphism	NNS
cord-322966-o65fo853	62	6	that	that	WDT
cord-322966-o65fo853	62	7	cause	cause	VBP
cord-322966-o65fo853	62	8	insertion	insertion	NN
cord-322966-o65fo853	62	9	(	(	-LRB-
cord-322966-o65fo853	62	10	I	i	NN
cord-322966-o65fo853	62	11	)	)	-RRB-
cord-322966-o65fo853	62	12	or	or	CC
cord-322966-o65fo853	62	13	deletion	deletion	NN
cord-322966-o65fo853	62	14	(	(	-LRB-
cord-322966-o65fo853	62	15	D	D	NNP
cord-322966-o65fo853	62	16	)	)	-RRB-
cord-322966-o65fo853	62	17	of	of	IN
cord-322966-o65fo853	62	18	a	a	DT
cord-322966-o65fo853	62	19	sequence	sequence	NN
cord-322966-o65fo853	62	20	of	of	IN
cord-322966-o65fo853	62	21	the	the	DT
cord-322966-o65fo853	62	22	gene	gene	NN
cord-322966-o65fo853	62	23	,	,	,
cord-322966-o65fo853	62	24	and	and	CC
cord-322966-o65fo853	62	25	ACE	ace	NN
cord-322966-o65fo853	62	26	activity	activity	NN
cord-322966-o65fo853	62	27	levels	level	NNS
cord-322966-o65fo853	62	28	in	in	IN
cord-322966-o65fo853	62	29	DD	DD	NNP
cord-322966-o65fo853	62	30	carriers	carrier	NNS
cord-322966-o65fo853	62	31	are	be	VBP
cord-322966-o65fo853	62	32	approximately	approximately	RB
cord-322966-o65fo853	62	33	twice	twice	RB
cord-322966-o65fo853	62	34	that	that	WDT
cord-322966-o65fo853	62	35	found	find	VBD
cord-322966-o65fo853	62	36	in	in	IN
cord-322966-o65fo853	62	37	II	II	NNP
cord-322966-o65fo853	62	38	genotypes	genotype	NNS
cord-322966-o65fo853	62	39	[	[	-LRB-
cord-322966-o65fo853	62	40	7	7	CD
cord-322966-o65fo853	62	41	]	]	-RRB-
cord-322966-o65fo853	62	42	.	.	.
cord-322966-o65fo853	63	1	The	the	DT
cord-322966-o65fo853	63	2	possible	possible	JJ
cord-322966-o65fo853	63	3	impact	impact	NN
cord-322966-o65fo853	63	4	of	of	IN
cord-322966-o65fo853	63	5	ACE	ace	NN
cord-322966-o65fo853	63	6	genotype	genotype	NN
cord-322966-o65fo853	63	7	in	in	IN
cord-322966-o65fo853	63	8	the	the	DT
cord-322966-o65fo853	63	9	COVID-19	COVID-19	NNP
cord-322966-o65fo853	63	10	disease	disease	NN
cord-322966-o65fo853	63	11	state	state	NN
cord-322966-o65fo853	63	12	,	,	,
cord-322966-o65fo853	63	13	when	when	WRB
cord-322966-o65fo853	63	14	the	the	DT
cord-322966-o65fo853	63	15	ability	ability	NN
cord-322966-o65fo853	63	16	to	to	TO
cord-322966-o65fo853	63	17	breakdown	breakdown	VB
cord-322966-o65fo853	63	18	Ang	Ang	NNP
cord-322966-o65fo853	63	19	II	II	NNP
cord-322966-o65fo853	63	20	is	be	VBZ
cord-322966-o65fo853	63	21	impaired	impair	VBN
cord-322966-o65fo853	63	22	,	,	,
cord-322966-o65fo853	63	23	could	could	MD
cord-322966-o65fo853	63	24	be	be	VB
cord-322966-o65fo853	63	25	hypothesised	hypothesise	VBN
cord-322966-o65fo853	63	26	to	to	TO
cord-322966-o65fo853	63	27	cause	cause	VB
cord-322966-o65fo853	63	28	a	a	DT
cord-322966-o65fo853	63	29	greater	great	JJR
cord-322966-o65fo853	63	30	quantity	quantity	NN
cord-322966-o65fo853	63	31	of	of	IN
cord-322966-o65fo853	63	32	circulating	circulate	VBG
cord-322966-o65fo853	63	33	Ang	Ang	NNP
cord-322966-o65fo853	63	34	II	II	NNP
cord-322966-o65fo853	63	35	and	and	CC
cord-322966-o65fo853	63	36	a	a	DT
cord-322966-o65fo853	63	37	more	more	RBR
cord-322966-o65fo853	63	38	marked	marked	JJ
cord-322966-o65fo853	63	39	imbalance	imbalance	NN
cord-322966-o65fo853	63	40	of	of	IN
cord-322966-o65fo853	63	41	the	the	DT
cord-322966-o65fo853	63	42	RAS	RAS	NNP
cord-322966-o65fo853	63	43	and	and	CC
cord-322966-o65fo853	63	44	more	more	RBR
cord-322966-o65fo853	63	45	severe	severe	JJ
cord-322966-o65fo853	63	46	disease	disease	NN
cord-322966-o65fo853	63	47	.	.	.
cord-322966-o65fo853	64	1	Genetic	genetic	JJ
cord-322966-o65fo853	64	2	and	and	CC
cord-322966-o65fo853	64	3	environmental	environmental	JJ
cord-322966-o65fo853	64	4	factors	factor	NNS
cord-322966-o65fo853	64	5	influencing	influence	VBG
cord-322966-o65fo853	64	6	ACE-2	ACE-2	NNP
cord-322966-o65fo853	64	7	expression	expression	NN
cord-322966-o65fo853	64	8	could	could	MD
cord-322966-o65fo853	64	9	also	also	RB
cord-322966-o65fo853	64	10	result	result	VB
cord-322966-o65fo853	64	11	in	in	IN
cord-322966-o65fo853	64	12	differences	difference	NNS
cord-322966-o65fo853	64	13	in	in	IN
cord-322966-o65fo853	64	14	the	the	DT
cord-322966-o65fo853	64	15	risk	risk	NN
cord-322966-o65fo853	64	16	of	of	IN
cord-322966-o65fo853	64	17	becoming	become	VBG
cord-322966-o65fo853	64	18	infected	infect	VBN
cord-322966-o65fo853	64	19	in	in	IN
cord-322966-o65fo853	64	20	the	the	DT
cord-322966-o65fo853	64	21	first	first	JJ
cord-322966-o65fo853	64	22	place	place	NN
cord-322966-o65fo853	64	23	by	by	IN
cord-322966-o65fo853	64	24	affecting	affect	VBG
cord-322966-o65fo853	64	25	the	the	DT
cord-322966-o65fo853	64	26	affinity	affinity	NN
cord-322966-o65fo853	64	27	of	of	IN
cord-322966-o65fo853	64	28	the	the	DT
cord-322966-o65fo853	64	29	ACE-2	ACE-2	NNP
cord-322966-o65fo853	64	30	binding	bind	VBG
cord-322966-o65fo853	64	31	domain	domain	NN
cord-322966-o65fo853	64	32	for	for	IN
cord-322966-o65fo853	64	33	the	the	DT
cord-322966-o65fo853	64	34	viral	viral	JJ
cord-322966-o65fo853	64	35	spike	spike	NN
cord-322966-o65fo853	64	36	protein	protein	NN
cord-322966-o65fo853	64	37	and	and	CC
cord-322966-o65fo853	64	38	by	by	IN
cord-322966-o65fo853	64	39	causing	cause	VBG
cord-322966-o65fo853	64	40	differences	difference	NNS
cord-322966-o65fo853	64	41	in	in	IN
cord-322966-o65fo853	64	42	the	the	DT
cord-322966-o65fo853	64	43	density	density	NN
cord-322966-o65fo853	64	44	of	of	IN
cord-322966-o65fo853	64	45	ACE-2	ACE-2	NNP
cord-322966-o65fo853	64	46	receptors	receptor	NNS
cord-322966-o65fo853	64	47	present	present	JJ
cord-322966-o65fo853	64	48	in	in	IN
cord-322966-o65fo853	64	49	tissues	tissue	NNS
cord-322966-o65fo853	64	50	such	such	JJ
cord-322966-o65fo853	64	51	as	as	IN
cord-322966-o65fo853	64	52	the	the	DT
cord-322966-o65fo853	64	53	lungs	lung	NNS
cord-322966-o65fo853	64	54	.	.	.
cord-322966-o65fo853	65	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	65	2	polymorphisms	polymorphism	NNS
cord-322966-o65fo853	65	3	may	may	MD
cord-322966-o65fo853	65	4	then	then	RB
cord-322966-o65fo853	65	5	contribute	contribute	VB
cord-322966-o65fo853	65	6	to	to	IN
cord-322966-o65fo853	65	7	significant	significant	JJ
cord-322966-o65fo853	65	8	differences	difference	NNS
cord-322966-o65fo853	65	9	in	in	IN
cord-322966-o65fo853	65	10	disease	disease	NN
cord-322966-o65fo853	65	11	severity	severity	NN
cord-322966-o65fo853	65	12	by	by	IN
cord-322966-o65fo853	65	13	determining	determine	VBG
cord-322966-o65fo853	65	14	the	the	DT
cord-322966-o65fo853	65	15	extent	extent	NN
cord-322966-o65fo853	65	16	of	of	IN
cord-322966-o65fo853	65	17	the	the	DT
cord-322966-o65fo853	65	18	ACE	ace	NN
cord-322966-o65fo853	65	19	:	:	:
cord-322966-o65fo853	66	1	ACE2	ace2	JJ
cord-322966-o65fo853	66	2	imbalance	imbalance	NN
cord-322966-o65fo853	66	3	,	,	,
cord-322966-o65fo853	66	4	particularly	particularly	RB
cord-322966-o65fo853	66	5	in	in	IN
cord-322966-o65fo853	66	6	the	the	DT
cord-322966-o65fo853	66	7	endothelium	endothelium	NN
cord-322966-o65fo853	66	8	of	of	IN
cord-322966-o65fo853	66	9	the	the	DT
cord-322966-o65fo853	66	10	lungs	lung	NNS
cord-322966-o65fo853	66	11	,	,	,
cord-322966-o65fo853	66	12	where	where	WRB
cord-322966-o65fo853	66	13	the	the	DT
cord-322966-o65fo853	66	14	virus	virus	NN
cord-322966-o65fo853	66	15	attacks	attack	NNS
cord-322966-o65fo853	66	16	at	at	IN
cord-322966-o65fo853	66	17	the	the	DT
cord-322966-o65fo853	66	18	same	same	JJ
cord-322966-o65fo853	66	19	time	time	NN
cord-322966-o65fo853	66	20	as	as	IN
cord-322966-o65fo853	66	21	disabling	disable	VBG
cord-322966-o65fo853	66	22	the	the	DT
cord-322966-o65fo853	66	23	ACE2-mediated	ace2-mediate	VBN
cord-322966-o65fo853	66	24	repair	repair	NN
cord-322966-o65fo853	66	25	systems	system	NNS
cord-322966-o65fo853	66	26	.	.	.
cord-322966-o65fo853	67	1	Chen	Chen	NNP
cord-322966-o65fo853	67	2	and	and	CC
cord-322966-o65fo853	67	3	co	co	NNS
cord-322966-o65fo853	67	4	-	-	NNS
cord-322966-o65fo853	67	5	workers	worker	NNS
cord-322966-o65fo853	67	6	(	(	-LRB-
cord-322966-o65fo853	67	7	2020	2020	CD
cord-322966-o65fo853	67	8	)	)	-RRB-
cord-322966-o65fo853	67	9	[	[	-LRB-
cord-322966-o65fo853	67	10	8	8	CD
cord-322966-o65fo853	67	11	]	]	-RRB-
cord-322966-o65fo853	67	12	have	have	VBP
cord-322966-o65fo853	67	13	analysed	analyse	VBN
cord-322966-o65fo853	67	14	30	30	CD
cord-322966-o65fo853	67	15	tissues	tissue	NNS
cord-322966-o65fo853	67	16	in	in	IN
cord-322966-o65fo853	67	17	thousands	thousand	NNS
cord-322966-o65fo853	67	18	of	of	IN
cord-322966-o65fo853	67	19	individuals	individual	NNS
cord-322966-o65fo853	67	20	and	and	CC
cord-322966-o65fo853	67	21	found	find	VBD
cord-322966-o65fo853	67	22	significantly	significantly	RB
cord-322966-o65fo853	67	23	higher	high	JJR
cord-322966-o65fo853	67	24	tissue	tissue	NN
cord-322966-o65fo853	67	25	ACE-2	ACE-2	NNP
cord-322966-o65fo853	67	26	in	in	IN
cord-322966-o65fo853	67	27	Asian	asian	JJ
cord-322966-o65fo853	67	28	females	female	NNS
cord-322966-o65fo853	67	29	compared	compare	VBN
cord-322966-o65fo853	67	30	to	to	IN
cord-322966-o65fo853	67	31	males	male	NNS
cord-322966-o65fo853	67	32	and	and	CC
cord-322966-o65fo853	67	33	other	other	JJ
cord-322966-o65fo853	67	34	ethnic	ethnic	JJ
cord-322966-o65fo853	67	35	groups	group	NNS
cord-322966-o65fo853	67	36	.	.	.
cord-322966-o65fo853	68	1	They	-PRON-	PRP
cord-322966-o65fo853	68	2	have	have	VBP
cord-322966-o65fo853	68	3	described	describe	VBN
cord-322966-o65fo853	68	4	an	an	DT
cord-322966-o65fo853	68	5	age	age	NN
cord-322966-o65fo853	68	6	-	-	HYPH
cord-322966-o65fo853	68	7	dependent	dependent	JJ
cord-322966-o65fo853	68	8	decrease	decrease	NN
cord-322966-o65fo853	68	9	in	in	IN
cord-322966-o65fo853	68	10	ACE-2	ACE-2	NNP
cord-322966-o65fo853	68	11	expression	expression	NN
cord-322966-o65fo853	68	12	and	and	CC
cord-322966-o65fo853	68	13	a	a	DT
cord-322966-o65fo853	68	14	highly	highly	RB
cord-322966-o65fo853	68	15	significant	significant	JJ
cord-322966-o65fo853	68	16	decrease	decrease	NN
cord-322966-o65fo853	68	17	in	in	IN
cord-322966-o65fo853	68	18	type	type	NN
cord-322966-o65fo853	68	19	II	ii	CD
cord-322966-o65fo853	68	20	diabetic	diabetic	JJ
cord-322966-o65fo853	68	21	patients	patient	NNS
cord-322966-o65fo853	68	22	.	.	.
cord-322966-o65fo853	69	1	The	the	DT
cord-322966-o65fo853	69	2	loci	locus	NNS
cord-322966-o65fo853	69	3	for	for	IN
cord-322966-o65fo853	69	4	higher	high	JJR
cord-322966-o65fo853	69	5	ACE-2	ACE-2	NNP
cord-322966-o65fo853	69	6	expression	expression	NN
cord-322966-o65fo853	69	7	is	be	VBZ
cord-322966-o65fo853	69	8	almost	almost	RB
cord-322966-o65fo853	69	9	100	100	CD
cord-322966-o65fo853	69	10	%	%	NN
cord-322966-o65fo853	69	11	in	in	IN
cord-322966-o65fo853	69	12	East	East	NNP
cord-322966-o65fo853	69	13	Asians	Asians	NNPS
cord-322966-o65fo853	69	14	and	and	CC
cord-322966-o65fo853	69	15	>	>	XX
cord-322966-o65fo853	69	16	30	30	CD
cord-322966-o65fo853	69	17	%	%	NN
cord-322966-o65fo853	69	18	higher	high	JJR
cord-322966-o65fo853	69	19	than	than	IN
cord-322966-o65fo853	69	20	other	other	JJ
cord-322966-o65fo853	69	21	ethnic	ethnic	JJ
cord-322966-o65fo853	69	22	groups	group	NNS
cord-322966-o65fo853	69	23	.	.	.
cord-322966-o65fo853	70	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	70	2	is	be	VBZ
cord-322966-o65fo853	70	3	suppressed	suppress	VBN
cord-322966-o65fo853	70	4	by	by	IN
cord-322966-o65fo853	70	5	inflammatory	inflammatory	JJ
cord-322966-o65fo853	70	6	cytokines	cytokine	NNS
cord-322966-o65fo853	70	7	,	,	,
cord-322966-o65fo853	70	8	by	by	IN
cord-322966-o65fo853	70	9	diabetes	diabetes	NN
cord-322966-o65fo853	70	10	and	and	CC
cord-322966-o65fo853	70	11	induced	induce	VBN
cord-322966-o65fo853	70	12	by	by	IN
cord-322966-o65fo853	70	13	oestrogen	oestrogen	NN
cord-322966-o65fo853	70	14	and	and	CC
cord-322966-o65fo853	70	15	androgen	androgen	NN
cord-322966-o65fo853	70	16	,	,	,
cord-322966-o65fo853	70	17	both	both	DT
cord-322966-o65fo853	70	18	of	of	IN
cord-322966-o65fo853	70	19	which	which	WDT
cord-322966-o65fo853	70	20	are	be	VBP
cord-322966-o65fo853	70	21	decreased	decrease	VBN
cord-322966-o65fo853	70	22	in	in	IN
cord-322966-o65fo853	70	23	the	the	DT
cord-322966-o65fo853	70	24	elderly	elderly	JJ
cord-322966-o65fo853	70	25	.	.	.
cord-322966-o65fo853	71	1	The	the	DT
cord-322966-o65fo853	71	2	work	work	NN
cord-322966-o65fo853	71	3	by	by	IN
cord-322966-o65fo853	71	4	Chen	Chen	NNP
cord-322966-o65fo853	71	5	and	and	CC
cord-322966-o65fo853	71	6	co	co	NNS
cord-322966-o65fo853	71	7	-	-	NNS
cord-322966-o65fo853	71	8	workers	worker	NNS
cord-322966-o65fo853	71	9	suggests	suggest	VBZ
cord-322966-o65fo853	71	10	a	a	DT
cord-322966-o65fo853	71	11	negative	negative	JJ
cord-322966-o65fo853	71	12	correlation	correlation	NN
cord-322966-o65fo853	71	13	between	between	IN
cord-322966-o65fo853	71	14	COVID-19	COVID-19	NNP
cord-322966-o65fo853	71	15	mortality	mortality	NN
cord-322966-o65fo853	71	16	and	and	CC
cord-322966-o65fo853	71	17	tissue	tissue	NN
cord-322966-o65fo853	71	18	ACE-2	ACE-2	NNP
cord-322966-o65fo853	71	19	levels	level	NNS
cord-322966-o65fo853	71	20	,	,	,
cord-322966-o65fo853	71	21	at	at	IN
cord-322966-o65fo853	71	22	both	both	CC
cord-322966-o65fo853	71	23	a	a	DT
cord-322966-o65fo853	71	24	population	population	NN
cord-322966-o65fo853	71	25	and	and	CC
cord-322966-o65fo853	71	26	molecular	molecular	JJ
cord-322966-o65fo853	71	27	level	level	NN
cord-322966-o65fo853	71	28	[	[	-LRB-
cord-322966-o65fo853	71	29	8	8	CD
cord-322966-o65fo853	71	30	]	]	-RRB-
cord-322966-o65fo853	71	31	.	.	.
cord-322966-o65fo853	72	1	Circulating	circulate	VBG
cord-322966-o65fo853	72	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	72	3	,	,	,
cord-322966-o65fo853	72	4	however	however	RB
cord-322966-o65fo853	72	5	,	,	,
cord-322966-o65fo853	72	6	has	have	VBZ
cord-322966-o65fo853	72	7	been	be	VBN
cord-322966-o65fo853	72	8	described	describe	VBN
cord-322966-o65fo853	72	9	to	to	TO
cord-322966-o65fo853	72	10	increase	increase	VB
cord-322966-o65fo853	72	11	in	in	IN
cord-322966-o65fo853	72	12	pathological	pathological	JJ
cord-322966-o65fo853	72	13	states	state	NNS
cord-322966-o65fo853	72	14	such	such	JJ
cord-322966-o65fo853	72	15	as	as	IN
cord-322966-o65fo853	72	16	hypertension	hypertension	NN
cord-322966-o65fo853	72	17	,	,	,
cord-322966-o65fo853	72	18	diabetes	diabetes	NN
cord-322966-o65fo853	72	19	and	and	CC
cord-322966-o65fo853	72	20	heart	heart	NN
cord-322966-o65fo853	72	21	failure	failure	NN
cord-322966-o65fo853	72	22	and	and	CC
cord-322966-o65fo853	72	23	perhaps	perhaps	RB
cord-322966-o65fo853	72	24	differences	difference	NNS
cord-322966-o65fo853	72	25	in	in	IN
cord-322966-o65fo853	72	26	circulating	circulate	VBG
cord-322966-o65fo853	72	27	,	,	,
cord-322966-o65fo853	72	28	shed	shed	VBN
cord-322966-o65fo853	72	29	ACE-2	ACE-2	NNP
cord-322966-o65fo853	72	30	and	and	CC
cord-322966-o65fo853	73	1	tissue	tissue	NN
cord-322966-o65fo853	73	2	-	-	HYPH
cord-322966-o65fo853	73	3	bound	bind	VBN
cord-322966-o65fo853	73	4	ACE-2	ACE-2	NNP
cord-322966-o65fo853	73	5	are	be	VBP
cord-322966-o65fo853	73	6	key	key	JJ
cord-322966-o65fo853	73	7	in	in	IN
cord-322966-o65fo853	73	8	virus	virus	NN
cord-322966-o65fo853	73	9	susceptibility	susceptibility	NN
cord-322966-o65fo853	73	10	and	and	CC
cord-322966-o65fo853	73	11	subsequent	subsequent	JJ
cord-322966-o65fo853	73	12	disease	disease	NN
cord-322966-o65fo853	73	13	severity	severity	NN
cord-322966-o65fo853	73	14	.	.	.
cord-322966-o65fo853	74	1	Gender	gender	NN
cord-322966-o65fo853	74	2	Differences	difference	NNS
cord-322966-o65fo853	74	3	in	in	IN
cord-322966-o65fo853	74	4	ACE-2	ACE-2	NNP
cord-322966-o65fo853	74	5	ACE-2	ACE-2	NNP
cord-322966-o65fo853	74	6	is	be	VBZ
cord-322966-o65fo853	74	7	on	on	IN
cord-322966-o65fo853	74	8	the	the	DT
cord-322966-o65fo853	74	9	X	x	NN
cord-322966-o65fo853	74	10	chromosome	chromosome	NN
cord-322966-o65fo853	74	11	,	,	,
cord-322966-o65fo853	74	12	hence	hence	RB
cord-322966-o65fo853	74	13	men	man	NNS
cord-322966-o65fo853	74	14	have	have	VBP
cord-322966-o65fo853	74	15	only	only	RB
cord-322966-o65fo853	74	16	one	one	CD
cord-322966-o65fo853	74	17	allele	allele	NN
cord-322966-o65fo853	74	18	and	and	CC
cord-322966-o65fo853	74	19	women	woman	NNS
cord-322966-o65fo853	75	1	have	have	VBP
cord-322966-o65fo853	75	2	two	two	CD
cord-322966-o65fo853	75	3	[	[	-LRB-
cord-322966-o65fo853	75	4	6	6	CD
cord-322966-o65fo853	75	5	,	,	,
cord-322966-o65fo853	75	6	31	31	CD
cord-322966-o65fo853	75	7	]	]	-RRB-
cord-322966-o65fo853	75	8	.	.	.
cord-322966-o65fo853	76	1	Further	further	RB
cord-322966-o65fo853	76	2	to	to	IN
cord-322966-o65fo853	76	3	this	this	DT
cord-322966-o65fo853	76	4	,	,	,
cord-322966-o65fo853	76	5	oestrogen	oestrogen	NN
cord-322966-o65fo853	76	6	is	be	VBZ
cord-322966-o65fo853	76	7	believed	believe	VBN
cord-322966-o65fo853	76	8	to	to	TO
cord-322966-o65fo853	76	9	upregulate	upregulate	VB
cord-322966-o65fo853	76	10	ACE-2	ACE-2	NNP
cord-322966-o65fo853	76	11	expression	expression	NN
cord-322966-o65fo853	76	12	[	[	-LRB-
cord-322966-o65fo853	76	13	32	32	CD
cord-322966-o65fo853	76	14	]	]	-RRB-
cord-322966-o65fo853	76	15	,	,	,
cord-322966-o65fo853	76	16	giving	give	VBG
cord-322966-o65fo853	76	17	pre	pre	JJ
cord-322966-o65fo853	76	18	-	-	JJ
cord-322966-o65fo853	76	19	menopausal	menopausal	JJ
cord-322966-o65fo853	76	20	women	woman	NNS
cord-322966-o65fo853	76	21	the	the	DT
cord-322966-o65fo853	76	22	advantage	advantage	NN
cord-322966-o65fo853	76	23	of	of	IN
cord-322966-o65fo853	76	24	two	two	CD
cord-322966-o65fo853	76	25	alleles	allele	NNS
cord-322966-o65fo853	76	26	and	and	CC
cord-322966-o65fo853	76	27	oestrogen	oestrogen	NN
cord-322966-o65fo853	76	28	upregulation	upregulation	NN
cord-322966-o65fo853	76	29	,	,	,
cord-322966-o65fo853	76	30	making	make	VBG
cord-322966-o65fo853	76	31	a	a	DT
cord-322966-o65fo853	76	32	deficiency	deficiency	NN
cord-322966-o65fo853	76	33	of	of	IN
cord-322966-o65fo853	76	34	ACE-2	ACE-2	NNP
cord-322966-o65fo853	76	35	and	and	CC
cord-322966-o65fo853	76	36	its	-PRON-	PRP$
cord-322966-o65fo853	76	37	ability	ability	NN
cord-322966-o65fo853	76	38	to	to	TO
cord-322966-o65fo853	76	39	rally	rally	VB
cord-322966-o65fo853	76	40	less	less	RBR
cord-322966-o65fo853	76	41	likely	likely	JJ
cord-322966-o65fo853	76	42	in	in	IN
cord-322966-o65fo853	76	43	the	the	DT
cord-322966-o65fo853	76	44	event	event	NN
cord-322966-o65fo853	76	45	of	of	IN
cord-322966-o65fo853	76	46	a	a	DT
cord-322966-o65fo853	76	47	viral	viral	JJ
cord-322966-o65fo853	76	48	attack	attack	NN
cord-322966-o65fo853	76	49	.	.	.
cord-322966-o65fo853	77	1	In	in	IN
cord-322966-o65fo853	77	2	support	support	NN
cord-322966-o65fo853	77	3	of	of	IN
cord-322966-o65fo853	77	4	this	this	DT
cord-322966-o65fo853	77	5	hypothesis	hypothesis	NN
cord-322966-o65fo853	77	6	,	,	,
cord-322966-o65fo853	77	7	the	the	DT
cord-322966-o65fo853	77	8	Chinese	chinese	JJ
cord-322966-o65fo853	77	9	CDCC	cdcc	NN
cord-322966-o65fo853	77	10	reported	report	VBD
cord-322966-o65fo853	77	11	overall	overall	JJ
cord-322966-o65fo853	77	12	female	female	JJ
cord-322966-o65fo853	77	13	mortality	mortality	NN
cord-322966-o65fo853	77	14	of	of	IN
cord-322966-o65fo853	77	15	1.7	1.7	CD
cord-322966-o65fo853	77	16	%	%	NN
cord-322966-o65fo853	77	17	including	include	VBG
cord-322966-o65fo853	77	18	suspected	suspect	VBN
cord-322966-o65fo853	77	19	cases	case	NNS
cord-322966-o65fo853	77	20	as	as	RB
cord-322966-o65fo853	77	21	well	well	RB
cord-322966-o65fo853	77	22	as	as	IN
cord-322966-o65fo853	77	23	serologically	serologically	RB
cord-322966-o65fo853	77	24	confirmed	confirm	VBN
cord-322966-o65fo853	77	25	cases	case	NNS
cord-322966-o65fo853	77	26	versus	versus	IN
cord-322966-o65fo853	77	27	2.8	2.8	CD
cord-322966-o65fo853	77	28	%	%	NN
cord-322966-o65fo853	77	29	in	in	IN
cord-322966-o65fo853	77	30	males	male	NNS
cord-322966-o65fo853	77	31	.	.	.
cord-322966-o65fo853	78	1	This	this	DT
cord-322966-o65fo853	78	2	difference	difference	NN
cord-322966-o65fo853	78	3	was	be	VBD
cord-322966-o65fo853	78	4	more	more	RBR
cord-322966-o65fo853	78	5	marked	mark	VBN
cord-322966-o65fo853	78	6	in	in	IN
cord-322966-o65fo853	78	7	serologically	serologically	RB
cord-322966-o65fo853	78	8	confirmed	confirm	VBN
cord-322966-o65fo853	78	9	cases	case	NNS
cord-322966-o65fo853	78	10	,	,	,
cord-322966-o65fo853	78	11	2.8	2.8	CD
cord-322966-o65fo853	78	12	%	%	NN
cord-322966-o65fo853	78	13	female	female	NN
cord-322966-o65fo853	78	14	versus	versus	IN
cord-322966-o65fo853	78	15	4.7	4.7	CD
cord-322966-o65fo853	78	16	%	%	NN
cord-322966-o65fo853	78	17	male	male	JJ
cord-322966-o65fo853	78	18	mortality	mortality	NN
cord-322966-o65fo853	78	19	.	.	.
cord-322966-o65fo853	79	1	The	the	DT
cord-322966-o65fo853	79	2	overall	overall	JJ
cord-322966-o65fo853	79	3	ratio	ratio	NN
cord-322966-o65fo853	79	4	was	be	VBD
cord-322966-o65fo853	79	5	1.06	1.06	CD
cord-322966-o65fo853	79	6	males	male	NNS
cord-322966-o65fo853	79	7	to	to	IN
cord-322966-o65fo853	79	8	1.0	1.0	CD
cord-322966-o65fo853	79	9	females	female	NNS
cord-322966-o65fo853	79	10	believed	believe	VBD
cord-322966-o65fo853	79	11	infected	infect	VBN
cord-322966-o65fo853	79	12	[	[	-LRB-
cord-322966-o65fo853	79	13	2	2	CD
cord-322966-o65fo853	79	14	]	]	-RRB-
cord-322966-o65fo853	79	15	.	.	.
cord-322966-o65fo853	80	1	Hence	hence	RB
cord-322966-o65fo853	80	2	the	the	DT
cord-322966-o65fo853	80	3	men	man	NNS
cord-322966-o65fo853	80	4	were	be	VBD
cord-322966-o65fo853	80	5	not	not	RB
cord-322966-o65fo853	80	6	significantly	significantly	RB
cord-322966-o65fo853	80	7	less	less	RBR
cord-322966-o65fo853	80	8	likely	likely	JJ
cord-322966-o65fo853	80	9	to	to	TO
cord-322966-o65fo853	80	10	become	become	VB
cord-322966-o65fo853	80	11	infected	infected	JJ
cord-322966-o65fo853	80	12	,	,	,
cord-322966-o65fo853	80	13	just	just	RB
cord-322966-o65fo853	80	14	more	more	RBR
cord-322966-o65fo853	80	15	likely	likely	JJ
cord-322966-o65fo853	80	16	to	to	TO
cord-322966-o65fo853	80	17	have	have	VB
cord-322966-o65fo853	80	18	a	a	DT
cord-322966-o65fo853	80	19	more	more	RBR
cord-322966-o65fo853	80	20	severe	severe	JJ
cord-322966-o65fo853	80	21	pathophysiological	pathophysiological	JJ
cord-322966-o65fo853	80	22	expression	expression	NN
cord-322966-o65fo853	80	23	of	of	IN
cord-322966-o65fo853	80	24	the	the	DT
cord-322966-o65fo853	80	25	disease	disease	NN
cord-322966-o65fo853	80	26	.	.	.
cord-322966-o65fo853	81	1	Whilst	whilst	IN
cord-322966-o65fo853	81	2	the	the	DT
cord-322966-o65fo853	81	3	WHO	who	WP
cord-322966-o65fo853	81	4	suggested	suggest	VBD
cord-322966-o65fo853	81	5	[	[	-LRB-
cord-322966-o65fo853	81	6	9	9	CD
cord-322966-o65fo853	81	7	]	]	-RRB-
cord-322966-o65fo853	81	8	that	that	IN
cord-322966-o65fo853	81	9	these	these	DT
cord-322966-o65fo853	81	10	gender	gender	NN
cord-322966-o65fo853	81	11	differences	difference	NNS
cord-322966-o65fo853	81	12	may	may	MD
cord-322966-o65fo853	81	13	be	be	VB
cord-322966-o65fo853	81	14	driven	drive	VBN
cord-322966-o65fo853	81	15	by	by	IN
cord-322966-o65fo853	81	16	substantially	substantially	RB
cord-322966-o65fo853	81	17	greater	great	JJR
cord-322966-o65fo853	81	18	rates	rate	NNS
cord-322966-o65fo853	81	19	of	of	IN
cord-322966-o65fo853	81	20	smoking	smoking	NN
cord-322966-o65fo853	81	21	in	in	IN
cord-322966-o65fo853	81	22	the	the	DT
cord-322966-o65fo853	81	23	Chinese	chinese	JJ
cord-322966-o65fo853	81	24	male	male	JJ
cord-322966-o65fo853	81	25	population	population	NN
cord-322966-o65fo853	81	26	,	,	,
cord-322966-o65fo853	81	27	the	the	DT
cord-322966-o65fo853	81	28	rates	rate	NNS
cord-322966-o65fo853	81	29	of	of	IN
cord-322966-o65fo853	81	30	smoking	smoking	NN
cord-322966-o65fo853	81	31	in	in	IN
cord-322966-o65fo853	81	32	the	the	DT
cord-322966-o65fo853	81	33	COVID-19	covid-19	JJ
cord-322966-o65fo853	81	34	cases	case	NNS
cord-322966-o65fo853	81	35	were	be	VBD
cord-322966-o65fo853	81	36	not	not	RB
cord-322966-o65fo853	81	37	provided	provide	VBN
cord-322966-o65fo853	81	38	in	in	IN
cord-322966-o65fo853	81	39	the	the	DT
cord-322966-o65fo853	81	40	epidemiological	epidemiological	JJ
cord-322966-o65fo853	81	41	study	study	NN
cord-322966-o65fo853	81	42	.	.	.
cord-322966-o65fo853	82	1	The	the	DT
cord-322966-o65fo853	82	2	X	x	NN
cord-322966-o65fo853	82	3	-	-	HYPH
cord-322966-o65fo853	82	4	linked	link	VBN
cord-322966-o65fo853	82	5	nature	nature	NN
cord-322966-o65fo853	82	6	of	of	IN
cord-322966-o65fo853	82	7	the	the	DT
cord-322966-o65fo853	82	8	ACE2	ACE2	NNP
cord-322966-o65fo853	82	9	gene	gene	NN
cord-322966-o65fo853	82	10	,	,	,
cord-322966-o65fo853	82	11	with	with	IN
cord-322966-o65fo853	82	12	females	female	NNS
cord-322966-o65fo853	82	13	having	have	VBG
cord-322966-o65fo853	82	14	a	a	DT
cord-322966-o65fo853	82	15	greater	great	JJR
cord-322966-o65fo853	82	16	range	range	NN
cord-322966-o65fo853	82	17	of	of	IN
cord-322966-o65fo853	82	18	phenotypes	phenotype	NNS
cord-322966-o65fo853	82	19	,	,	,
cord-322966-o65fo853	82	20	may	may	MD
cord-322966-o65fo853	82	21	have	have	VB
cord-322966-o65fo853	82	22	a	a	DT
cord-322966-o65fo853	82	23	greater	great	JJR
cord-322966-o65fo853	82	24	role	role	NN
cord-322966-o65fo853	82	25	than	than	IN
cord-322966-o65fo853	82	26	has	have	VBZ
cord-322966-o65fo853	82	27	been	be	VBN
cord-322966-o65fo853	82	28	yet	yet	RB
cord-322966-o65fo853	82	29	been	be	VBN
cord-322966-o65fo853	82	30	fully	fully	RB
cord-322966-o65fo853	82	31	defined	define	VBN
cord-322966-o65fo853	82	32	in	in	IN
cord-322966-o65fo853	82	33	coronavirus	coronavirus	NN
cord-322966-o65fo853	82	34	pathogenesis	pathogenesis	NN
cord-322966-o65fo853	82	35	gender	gender	NN
cord-322966-o65fo853	82	36	differences	difference	NNS
cord-322966-o65fo853	82	37	.	.	.
cord-322966-o65fo853	83	1	The	the	DT
cord-322966-o65fo853	83	2	range	range	NN
cord-322966-o65fo853	83	3	of	of	IN
cord-322966-o65fo853	83	4	ACE-2	ACE-2	NNP
cord-322966-o65fo853	83	5	phenotypes	phenotype	NNS
cord-322966-o65fo853	83	6	and	and	CC
cord-322966-o65fo853	83	7	their	-PRON-	PRP$
cord-322966-o65fo853	83	8	ability	ability	NN
cord-322966-o65fo853	83	9	to	to	TO
cord-322966-o65fo853	83	10	upregulate	upregulate	VB
cord-322966-o65fo853	83	11	compensatory	compensatory	JJ
cord-322966-o65fo853	83	12	mechanisms	mechanism	NNS
cord-322966-o65fo853	83	13	in	in	IN
cord-322966-o65fo853	83	14	the	the	DT
cord-322966-o65fo853	83	15	face	face	NN
cord-322966-o65fo853	83	16	of	of	IN
cord-322966-o65fo853	83	17	viral	viral	JJ
cord-322966-o65fo853	83	18	ACE-2	ACE-2	NNP
cord-322966-o65fo853	83	19	downregulation	downregulation	NN
cord-322966-o65fo853	83	20	may	may	MD
cord-322966-o65fo853	83	21	play	play	VB
cord-322966-o65fo853	83	22	a	a	DT
cord-322966-o65fo853	83	23	role	role	NN
cord-322966-o65fo853	83	24	.	.	.
cord-322966-o65fo853	84	1	Marked	marked	JJ
cord-322966-o65fo853	84	2	gender	gender	NN
cord-322966-o65fo853	84	3	differences	difference	NNS
cord-322966-o65fo853	84	4	in	in	IN
cord-322966-o65fo853	84	5	disease	disease	NN
cord-322966-o65fo853	84	6	have	have	VBP
cord-322966-o65fo853	84	7	been	be	VBN
cord-322966-o65fo853	84	8	confirmed	confirm	VBN
cord-322966-o65fo853	84	9	in	in	IN
cord-322966-o65fo853	84	10	other	other	JJ
cord-322966-o65fo853	84	11	large	large	JJ
cord-322966-o65fo853	84	12	observational	observational	JJ
cord-322966-o65fo853	84	13	studies	study	NNS
cord-322966-o65fo853	84	14	with	with	IN
cord-322966-o65fo853	84	15	Marcia	Marcia	NNP
cord-322966-o65fo853	84	16	et	et	NNP
cord-322966-o65fo853	84	17	al	al	NNP
cord-322966-o65fo853	84	18	reporting	report	VBG
cord-322966-o65fo853	84	19	37	37	CD
cord-322966-o65fo853	84	20	%	%	NN
cord-322966-o65fo853	84	21	women	woman	NNS
cord-322966-o65fo853	84	22	in	in	IN
cord-322966-o65fo853	84	23	6,232	6,232	CD
cord-322966-o65fo853	84	24	patients	patient	NNS
cord-322966-o65fo853	84	25	with	with	IN
cord-322966-o65fo853	84	26	COVID	COVID	NNP
cord-322966-o65fo853	84	27	and	and	CC
cord-322966-o65fo853	84	28	Mehra	Mehra	NNP
cord-322966-o65fo853	84	29	et	et	NNP
cord-322966-o65fo853	84	30	al	al	NNP
cord-322966-o65fo853	84	31	.	.	.
cord-322966-o65fo853	85	1	reported	report	VBD
cord-322966-o65fo853	85	2	40	40	CD
cord-322966-o65fo853	85	3	%	%	NN
cord-322966-o65fo853	85	4	female	female	JJ
cord-322966-o65fo853	85	5	patients	patient	NNS
cord-322966-o65fo853	85	6	in	in	IN
cord-322966-o65fo853	85	7	8,910	8,910	CD
cord-322966-o65fo853	85	8	COVID-19	covid-19	CD
cord-322966-o65fo853	85	9	patients	patient	NNS
cord-322966-o65fo853	85	10	requiring	require	VBG
cord-322966-o65fo853	85	11	hospital	hospital	NN
cord-322966-o65fo853	85	12	admission	admission	NN
cord-322966-o65fo853	85	13	and	and	CC
cord-322966-o65fo853	85	14	furthermore	furthermore	RB
cord-322966-o65fo853	85	15	reported	report	VBD
cord-322966-o65fo853	85	16	improved	improved	JJ
cord-322966-o65fo853	85	17	survival	survival	NN
cord-322966-o65fo853	85	18	in	in	IN
cord-322966-o65fo853	85	19	female	female	JJ
cord-322966-o65fo853	85	20	patients	patient	NNS
cord-322966-o65fo853	85	21	,	,	,
cord-322966-o65fo853	85	22	independent	independent	JJ
cord-322966-o65fo853	85	23	of	of	IN
cord-322966-o65fo853	85	24	older	old	JJR
cord-322966-o65fo853	85	25	age	age	NN
cord-322966-o65fo853	85	26	[	[	-LRB-
cord-322966-o65fo853	85	27	10	10	CD
cord-322966-o65fo853	85	28	]	]	-RRB-
cord-322966-o65fo853	85	29	.	.	.
cord-322966-o65fo853	86	1	Serum	serum	NN
cord-322966-o65fo853	86	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	86	3	levels	level	NNS
cord-322966-o65fo853	86	4	are	be	VBP
cord-322966-o65fo853	86	5	reported	report	VBN
cord-322966-o65fo853	86	6	to	to	TO
cord-322966-o65fo853	86	7	be	be	VB
cord-322966-o65fo853	86	8	significantly	significantly	RB
cord-322966-o65fo853	86	9	lower	low	JJR
cord-322966-o65fo853	86	10	in	in	IN
cord-322966-o65fo853	86	11	females	female	NNS
cord-322966-o65fo853	86	12	[	[	-LRB-
cord-322966-o65fo853	86	13	23	23	CD
cord-322966-o65fo853	86	14	]	]	-RRB-
cord-322966-o65fo853	86	15	and	and	CC
cord-322966-o65fo853	86	16	there	there	EX
cord-322966-o65fo853	86	17	are	be	VBP
cord-322966-o65fo853	86	18	fundamental	fundamental	JJ
cord-322966-o65fo853	86	19	differences	difference	NNS
cord-322966-o65fo853	86	20	in	in	IN
cord-322966-o65fo853	86	21	immune	immune	JJ
cord-322966-o65fo853	86	22	responses	response	NNS
cord-322966-o65fo853	86	23	to	to	IN
cord-322966-o65fo853	86	24	viral	viral	JJ
cord-322966-o65fo853	86	25	infections	infection	NNS
cord-322966-o65fo853	86	26	based	base	VBN
cord-322966-o65fo853	86	27	on	on	IN
cord-322966-o65fo853	86	28	gender	gender	NN
cord-322966-o65fo853	86	29	with	with	IN
cord-322966-o65fo853	86	30	stronger	strong	JJR
cord-322966-o65fo853	86	31	humoral	humoral	JJ
cord-322966-o65fo853	86	32	and	and	CC
cord-322966-o65fo853	86	33	cellular	cellular	JJ
cord-322966-o65fo853	86	34	immune	immune	JJ
cord-322966-o65fo853	86	35	responses	response	NNS
cord-322966-o65fo853	86	36	described	describe	VBN
cord-322966-o65fo853	86	37	in	in	IN
cord-322966-o65fo853	86	38	females	female	NNS
cord-322966-o65fo853	86	39	[	[	-LRB-
cord-322966-o65fo853	86	40	33	33	CD
cord-322966-o65fo853	86	41	]	]	-RRB-
cord-322966-o65fo853	86	42	.	.	.
cord-322966-o65fo853	87	1	Smoking	smoking	NN
cord-322966-o65fo853	87	2	has	have	VBZ
cord-322966-o65fo853	87	3	been	be	VBN
cord-322966-o65fo853	87	4	linked	link	VBN
cord-322966-o65fo853	87	5	to	to	IN
cord-322966-o65fo853	87	6	upregulation	upregulation	NN
cord-322966-o65fo853	87	7	of	of	IN
cord-322966-o65fo853	87	8	ACE	ace	NN
cord-322966-o65fo853	87	9	and	and	CC
cord-322966-o65fo853	87	10	downregulation	downregulation	NN
cord-322966-o65fo853	87	11	of	of	IN
cord-322966-o65fo853	87	12	ACE-2	ACE-2	NNP
cord-322966-o65fo853	87	13	[	[	-LRB-
cord-322966-o65fo853	87	14	34	34	CD
cord-322966-o65fo853	87	15	]	]	-RRB-
cord-322966-o65fo853	87	16	,	,	,
cord-322966-o65fo853	87	17	which	which	WDT
cord-322966-o65fo853	87	18	could	could	MD
cord-322966-o65fo853	87	19	be	be	VB
cord-322966-o65fo853	87	20	hypothesised	hypothesise	VBN
cord-322966-o65fo853	87	21	to	to	TO
cord-322966-o65fo853	87	22	make	make	VB
cord-322966-o65fo853	87	23	smokers	smoker	NNS
cord-322966-o65fo853	87	24	less	less	RBR
cord-322966-o65fo853	87	25	likely	likely	JJ
cord-322966-o65fo853	87	26	than	than	IN
cord-322966-o65fo853	87	27	the	the	DT
cord-322966-o65fo853	87	28	general	general	JJ
cord-322966-o65fo853	87	29	population	population	NN
cord-322966-o65fo853	87	30	to	to	TO
cord-322966-o65fo853	87	31	become	become	VB
cord-322966-o65fo853	87	32	infected	infect	VBN
cord-322966-o65fo853	87	33	by	by	IN
cord-322966-o65fo853	87	34	virtue	virtue	NN
cord-322966-o65fo853	87	35	of	of	IN
cord-322966-o65fo853	87	36	having	have	VBG
cord-322966-o65fo853	87	37	less	less	JJR
cord-322966-o65fo853	87	38	ACE-2	ACE-2	NNP
cord-322966-o65fo853	87	39	required	require	VBN
cord-322966-o65fo853	87	40	for	for	IN
cord-322966-o65fo853	87	41	viral	viral	JJ
cord-322966-o65fo853	87	42	entry	entry	NN
cord-322966-o65fo853	87	43	.	.	.
cord-322966-o65fo853	88	1	However	however	RB
cord-322966-o65fo853	88	2	,	,	,
cord-322966-o65fo853	88	3	if	if	IN
cord-322966-o65fo853	88	4	a	a	DT
cord-322966-o65fo853	88	5	smoker	smoker	NN
cord-322966-o65fo853	88	6	becomes	become	VBZ
cord-322966-o65fo853	88	7	infected	infect	VBN
cord-322966-o65fo853	88	8	,	,	,
cord-322966-o65fo853	88	9	a	a	DT
cord-322966-o65fo853	88	10	pre	pre	JJ
cord-322966-o65fo853	88	11	-	-	JJ
cord-322966-o65fo853	88	12	existing	existing	JJ
cord-322966-o65fo853	88	13	ACE	ace	NN
cord-322966-o65fo853	88	14	:	:	:
cord-322966-o65fo853	89	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	89	2	imbalance	imbalance	NN
cord-322966-o65fo853	89	3	may	may	MD
cord-322966-o65fo853	89	4	result	result	VB
cord-322966-o65fo853	89	5	in	in	IN
cord-322966-o65fo853	89	6	more	more	JJR
cord-322966-o65fo853	89	7	severe	severe	JJ
cord-322966-o65fo853	89	8	disease	disease	NN
cord-322966-o65fo853	89	9	due	due	IN
cord-322966-o65fo853	89	10	to	to	IN
cord-322966-o65fo853	89	11	greater	great	JJR
cord-322966-o65fo853	89	12	inflammation	inflammation	NN
cord-322966-o65fo853	89	13	,	,	,
cord-322966-o65fo853	89	14	higher	high	JJR
cord-322966-o65fo853	89	15	risk	risk	NN
cord-322966-o65fo853	89	16	of	of	IN
cord-322966-o65fo853	89	17	ARDS	ARDS	NNP
cord-322966-o65fo853	89	18	and	and	CC
cord-322966-o65fo853	89	19	multi	multi	JJ
cord-322966-o65fo853	89	20	-	-	JJ
cord-322966-o65fo853	89	21	factorial	factorial	JJ
cord-322966-o65fo853	89	22	issues	issue	NNS
cord-322966-o65fo853	89	23	including	include	VBG
cord-322966-o65fo853	89	24	poor	poor	JJ
cord-322966-o65fo853	89	25	baseline	baseline	JJ
cord-322966-o65fo853	89	26	lung	lung	NN
cord-322966-o65fo853	89	27	function	function	NN
cord-322966-o65fo853	89	28	and	and	CC
cord-322966-o65fo853	89	29	bacterial	bacterial	JJ
cord-322966-o65fo853	89	30	superinfection	superinfection	NN
cord-322966-o65fo853	89	31	.	.	.
cord-322966-o65fo853	90	1	Evidence	evidence	NN
cord-322966-o65fo853	90	2	supporting	support	VBG
cord-322966-o65fo853	90	3	this	this	DT
cord-322966-o65fo853	90	4	picture	picture	NN
cord-322966-o65fo853	90	5	is	be	VBZ
cord-322966-o65fo853	90	6	seen	see	VBN
cord-322966-o65fo853	90	7	in	in	IN
cord-322966-o65fo853	90	8	data	datum	NNS
cord-322966-o65fo853	90	9	from	from	IN
cord-322966-o65fo853	90	10	Wuhan	Wuhan	NNP
cord-322966-o65fo853	90	11	.	.	.
cord-322966-o65fo853	91	1	Although	although	IN
cord-322966-o65fo853	91	2	smokers	smoker	NNS
cord-322966-o65fo853	91	3	are	be	VBP
cord-322966-o65fo853	91	4	said	say	VBN
cord-322966-o65fo853	91	5	to	to	TO
cord-322966-o65fo853	91	6	comprise	comprise	VB
cord-322966-o65fo853	91	7	52.1	52.1	CD
cord-322966-o65fo853	91	8	%	%	NN
cord-322966-o65fo853	91	9	of	of	IN
cord-322966-o65fo853	91	10	the	the	DT
cord-322966-o65fo853	91	11	male	male	JJ
cord-322966-o65fo853	91	12	population	population	NN
cord-322966-o65fo853	91	13	in	in	IN
cord-322966-o65fo853	91	14	China	China	NNP
cord-322966-o65fo853	91	15	[	[	-LRB-
cord-322966-o65fo853	91	16	9	9	CD
cord-322966-o65fo853	91	17	]	]	-RRB-
cord-322966-o65fo853	91	18	,	,	,
cord-322966-o65fo853	91	19	the	the	DT
cord-322966-o65fo853	91	20	rate	rate	NN
cord-322966-o65fo853	91	21	of	of	IN
cord-322966-o65fo853	91	22	current	current	JJ
cord-322966-o65fo853	91	23	smokers	smoker	NNS
cord-322966-o65fo853	91	24	reported	report	VBN
cord-322966-o65fo853	91	25	in	in	IN
cord-322966-o65fo853	91	26	COVID-19	COVID-19	NNP
cord-322966-o65fo853	91	27	series	series	NN
cord-322966-o65fo853	91	28	seems	seem	VBZ
cord-322966-o65fo853	91	29	well	well	RB
cord-322966-o65fo853	91	30	below	below	IN
cord-322966-o65fo853	91	31	this	this	DT
cord-322966-o65fo853	91	32	;	;	:
cord-322966-o65fo853	91	33	7	7	CD
cord-322966-o65fo853	91	34	%	%	NN
cord-322966-o65fo853	91	35	by	by	IN
cord-322966-o65fo853	91	36	Huang	Huang	NNP
cord-322966-o65fo853	91	37	et	et	NNP
cord-322966-o65fo853	91	38	al	al	NNP
cord-322966-o65fo853	91	39	.	.	.
cord-322966-o65fo853	92	1	[	[	-LRB-
cord-322966-o65fo853	92	2	Due	due	IN
cord-322966-o65fo853	92	3	to	to	IN
cord-322966-o65fo853	92	4	the	the	DT
cord-322966-o65fo853	92	5	extreme	extreme	JJ
cord-322966-o65fo853	92	6	complexity	complexity	NN
cord-322966-o65fo853	92	7	of	of	IN
cord-322966-o65fo853	92	8	the	the	DT
cord-322966-o65fo853	92	9	RAS	RAS	NNP
cord-322966-o65fo853	92	10	system	system	NN
cord-322966-o65fo853	92	11	,	,	,
cord-322966-o65fo853	92	12	another	another	DT
cord-322966-o65fo853	92	13	component	component	NN
cord-322966-o65fo853	92	14	may	may	MD
cord-322966-o65fo853	92	15	be	be	VB
cord-322966-o65fo853	92	16	relevant	relevant	JJ
cord-322966-o65fo853	92	17	in	in	IN
cord-322966-o65fo853	92	18	causing	cause	VBG
cord-322966-o65fo853	92	19	greater	great	JJR
cord-322966-o65fo853	92	20	mortality	mortality	NN
cord-322966-o65fo853	92	21	in	in	IN
cord-322966-o65fo853	92	22	smokers	smoker	NNS
cord-322966-o65fo853	92	23	with	with	IN
cord-322966-o65fo853	92	24	COVID-19	COVID-19	NNP
cord-322966-o65fo853	92	25	.	.	.
cord-322966-o65fo853	93	1	Neprilysin	Neprilysin	NNP
cord-322966-o65fo853	93	2	is	be	VBZ
cord-322966-o65fo853	93	3	a	a	DT
cord-322966-o65fo853	93	4	metalloprotease	metalloprotease	NN
cord-322966-o65fo853	93	5	that	that	WDT
cord-322966-o65fo853	93	6	has	have	VBZ
cord-322966-o65fo853	93	7	a	a	DT
cord-322966-o65fo853	93	8	number	number	NN
cord-322966-o65fo853	93	9	of	of	IN
cord-322966-o65fo853	93	10	functions	function	NNS
cord-322966-o65fo853	93	11	but	but	CC
cord-322966-o65fo853	93	12	can	can	MD
cord-322966-o65fo853	93	13	act	act	VB
cord-322966-o65fo853	93	14	to	to	TO
cord-322966-o65fo853	93	15	breakdown	breakdown	VB
cord-322966-o65fo853	93	16	Ang	Ang	NNP
cord-322966-o65fo853	93	17	II	II	NNP
cord-322966-o65fo853	93	18	to	to	IN
cord-322966-o65fo853	93	19	Ang(1	Ang(1	NNP
cord-322966-o65fo853	93	20	-	-	HYPH
cord-322966-o65fo853	93	21	7	7	CD
cord-322966-o65fo853	93	22	)	)	-RRB-
cord-322966-o65fo853	93	23	4	4	CD
cord-322966-o65fo853	93	24	,	,	,
cord-322966-o65fo853	93	25	the	the	DT
cord-322966-o65fo853	93	26	role	role	NN
cord-322966-o65fo853	93	27	usually	usually	RB
cord-322966-o65fo853	93	28	performed	perform	VBN
cord-322966-o65fo853	93	29	by	by	IN
cord-322966-o65fo853	93	30	ACE-2	ACE-2	NNP
cord-322966-o65fo853	93	31	.	.	.
cord-322966-o65fo853	94	1	It	-PRON-	PRP
cord-322966-o65fo853	94	2	is	be	VBZ
cord-322966-o65fo853	94	3	highly	highly	RB
cord-322966-o65fo853	94	4	expressed	express	VBN
cord-322966-o65fo853	94	5	in	in	IN
cord-322966-o65fo853	94	6	airways	airways	NNP
cord-322966-o65fo853	94	7	,	,	,
cord-322966-o65fo853	94	8	pulmonary	pulmonary	JJ
cord-322966-o65fo853	94	9	interstitium	interstitium	NN
cord-322966-o65fo853	94	10	and	and	CC
cord-322966-o65fo853	94	11	alveolar	alveolar	NN
cord-322966-o65fo853	94	12	cells	cell	NNS
cord-322966-o65fo853	94	13	.	.	.
cord-322966-o65fo853	95	1	A	a	DT
cord-322966-o65fo853	95	2	study	study	NN
cord-322966-o65fo853	95	3	examining	examine	VBG
cord-322966-o65fo853	95	4	circulating	circulate	VBG
cord-322966-o65fo853	95	5	neprilysin	neprilysin	NNP
cord-322966-o65fo853	95	6	levels	level	NNS
cord-322966-o65fo853	95	7	in	in	IN
cord-322966-o65fo853	95	8	1,536	1,536	CD
cord-322966-o65fo853	95	9	community	community	NN
cord-322966-o65fo853	95	10	-	-	HYPH
cord-322966-o65fo853	95	11	based	base	VBN
cord-322966-o65fo853	95	12	subjects	subject	NNS
cord-322966-o65fo853	95	13	>	>	NFP
cord-322966-o65fo853	95	14	45	45	CD
cord-322966-o65fo853	95	15	years	year	NNS
cord-322966-o65fo853	95	16	,	,	,
cord-322966-o65fo853	95	17	found	find	VBD
cord-322966-o65fo853	95	18	that	that	IN
cord-322966-o65fo853	95	19	the	the	DT
cord-322966-o65fo853	95	20	lowest	low	JJS
cord-322966-o65fo853	95	21	tertile	tertile	JJ
cord-322966-o65fo853	95	22	group	group	NN
cord-322966-o65fo853	95	23	had	have	VBD
cord-322966-o65fo853	95	24	the	the	DT
cord-322966-o65fo853	95	25	highest	high	JJS
cord-322966-o65fo853	95	26	rates	rate	NNS
cord-322966-o65fo853	95	27	of	of	IN
cord-322966-o65fo853	95	28	smokers	smoker	NNS
cord-322966-o65fo853	95	29	(	(	-LRB-
cord-322966-o65fo853	95	30	p<0.001	p<0.001	CD
cord-322966-o65fo853	95	31	)	)	-RRB-
cord-322966-o65fo853	95	32	and	and	CC
cord-322966-o65fo853	95	33	higher	high	JJR
cord-322966-o65fo853	95	34	rates	rate	NNS
cord-322966-o65fo853	95	35	of	of	IN
cord-322966-o65fo853	95	36	hypertension	hypertension	NN
cord-322966-o65fo853	95	37	(	(	-LRB-
cord-322966-o65fo853	95	38	p=0.04	p=0.04	NNP
cord-322966-o65fo853	95	39	)	)	-RRB-
cord-322966-o65fo853	95	40	[	[	-LRB-
cord-322966-o65fo853	95	41	38	38	CD
cord-322966-o65fo853	95	42	]	]	-RRB-
cord-322966-o65fo853	95	43	.	.	.
cord-322966-o65fo853	96	1	If	if	IN
cord-322966-o65fo853	96	2	smokers	smoker	NNS
cord-322966-o65fo853	96	3	have	have	VBP
cord-322966-o65fo853	96	4	low	low	JJ
cord-322966-o65fo853	96	5	lung	lung	NN
cord-322966-o65fo853	96	6	neprilysin	neprilysin	NNP
cord-322966-o65fo853	96	7	activity	activity	NN
cord-322966-o65fo853	96	8	,	,	,
cord-322966-o65fo853	96	9	they	-PRON-	PRP
cord-322966-o65fo853	96	10	may	may	MD
cord-322966-o65fo853	96	11	lack	lack	VB
cord-322966-o65fo853	96	12	an	an	DT
cord-322966-o65fo853	96	13	important	important	JJ
cord-322966-o65fo853	96	14	safety	safety	NN
cord-322966-o65fo853	96	15	mechanism	mechanism	NN
cord-322966-o65fo853	96	16	that	that	WDT
cord-322966-o65fo853	96	17	could	could	MD
cord-322966-o65fo853	96	18	overcome	overcome	VB
cord-322966-o65fo853	96	19	virally	virally	RB
cord-322966-o65fo853	96	20	mediated	mediate	VBN
cord-322966-o65fo853	96	21	loss	loss	NN
cord-322966-o65fo853	96	22	of	of	IN
cord-322966-o65fo853	96	23	the	the	DT
cord-322966-o65fo853	96	24	ACE-2	ACE-2	NNP
cord-322966-o65fo853	96	25	.	.	.
cord-322966-o65fo853	97	1	This	this	DT
cord-322966-o65fo853	97	2	might	may	MD
cord-322966-o65fo853	97	3	be	be	VB
cord-322966-o65fo853	97	4	relevant	relevant	JJ
cord-322966-o65fo853	97	5	in	in	IN
cord-322966-o65fo853	97	6	patients	patient	NNS
cord-322966-o65fo853	97	7	taking	take	VBG
cord-322966-o65fo853	97	8	Entresto	Entresto	NNP
cord-322966-o65fo853	97	9	(	(	-LRB-
cord-322966-o65fo853	97	10	sacubitril	sacubitril	NNP
cord-322966-o65fo853	97	11	/	/	SYM
cord-322966-o65fo853	97	12	valsartan	valsartan	NNP
cord-322966-o65fo853	97	13	)	)	-RRB-
cord-322966-o65fo853	97	14	,	,	,
cord-322966-o65fo853	97	15	a	a	DT
cord-322966-o65fo853	97	16	medication	medication	NN
cord-322966-o65fo853	97	17	with	with	IN
cord-322966-o65fo853	97	18	proven	prove	VBN
cord-322966-o65fo853	97	19	benefit	benefit	NN
cord-322966-o65fo853	97	20	in	in	IN
cord-322966-o65fo853	97	21	the	the	DT
cord-322966-o65fo853	97	22	treatment	treatment	NN
cord-322966-o65fo853	97	23	of	of	IN
cord-322966-o65fo853	97	24	patients	patient	NNS
cord-322966-o65fo853	97	25	with	with	IN
cord-322966-o65fo853	97	26	heart	heart	NN
cord-322966-o65fo853	97	27	failure	failure	NN
cord-322966-o65fo853	97	28	.	.	.
cord-322966-o65fo853	98	1	Neprilysin	Neprilysin	NNP
cord-322966-o65fo853	98	2	inhibition	inhibition	NN
cord-322966-o65fo853	98	3	by	by	IN
cord-322966-o65fo853	98	4	the	the	DT
cord-322966-o65fo853	98	5	sacubitril	sacubitril	NNP
cord-322966-o65fo853	98	6	component	component	NN
cord-322966-o65fo853	98	7	of	of	IN
cord-322966-o65fo853	98	8	Entresto	Entresto	NNP
cord-322966-o65fo853	98	9	may	may	MD
cord-322966-o65fo853	98	10	block	block	VB
cord-322966-o65fo853	98	11	the	the	DT
cord-322966-o65fo853	98	12	alternate	alternate	JJ
cord-322966-o65fo853	98	13	method	method	NN
cord-322966-o65fo853	98	14	of	of	IN
cord-322966-o65fo853	98	15	generating	generate	VBG
cord-322966-o65fo853	98	16	the	the	DT
cord-322966-o65fo853	98	17	anti	anti	JJ
cord-322966-o65fo853	98	18	-	-	JJ
cord-322966-o65fo853	98	19	inflammatory	inflammatory	JJ
cord-322966-o65fo853	98	20	mediator	mediator	NN
cord-322966-o65fo853	98	21	(	(	-LRB-
cord-322966-o65fo853	98	22	1	1	CD
cord-322966-o65fo853	98	23	-	-	SYM
cord-322966-o65fo853	98	24	7	7	CD
cord-322966-o65fo853	98	25	)	)	-RRB-
cord-322966-o65fo853	98	26	when	when	WRB
cord-322966-o65fo853	98	27	ACE-2	ACE-2	NNP
cord-322966-o65fo853	98	28	,	,	,
cord-322966-o65fo853	98	29	under	under	IN
cord-322966-o65fo853	98	30	viral	viral	JJ
cord-322966-o65fo853	98	31	attack	attack	NN
cord-322966-o65fo853	98	32	,	,	,
cord-322966-o65fo853	98	33	is	be	VBZ
cord-322966-o65fo853	98	34	less	less	RBR
cord-322966-o65fo853	98	35	able	able	JJ
cord-322966-o65fo853	98	36	to	to	TO
cord-322966-o65fo853	98	37	do	do	VB
cord-322966-o65fo853	98	38	so	so	RB
cord-322966-o65fo853	98	39	.	.	.
cord-322966-o65fo853	99	1	Clearly	clearly	RB
cord-322966-o65fo853	99	2	this	this	DT
cord-322966-o65fo853	99	3	is	be	VBZ
cord-322966-o65fo853	99	4	a	a	DT
cord-322966-o65fo853	99	5	complex	complex	JJ
cord-322966-o65fo853	99	6	question	question	NN
cord-322966-o65fo853	99	7	,	,	,
cord-322966-o65fo853	99	8	impossible	impossible	JJ
cord-322966-o65fo853	99	9	to	to	TO
cord-322966-o65fo853	99	10	answer	answer	VB
cord-322966-o65fo853	99	11	without	without	IN
cord-322966-o65fo853	99	12	more	more	JJR
cord-322966-o65fo853	99	13	data	datum	NNS
cord-322966-o65fo853	99	14	and	and	CC
cord-322966-o65fo853	99	15	even	even	RB
cord-322966-o65fo853	99	16	recently	recently	RB
cord-322966-o65fo853	99	17	reported	report	VBD
cord-322966-o65fo853	99	18	observational	observational	JJ
cord-322966-o65fo853	99	19	studies	study	NNS
cord-322966-o65fo853	99	20	did	do	VBD
cord-322966-o65fo853	99	21	not	not	RB
cord-322966-o65fo853	99	22	have	have	VB
cord-322966-o65fo853	99	23	sufficient	sufficient	JJ
cord-322966-o65fo853	99	24	patients	patient	NNS
cord-322966-o65fo853	99	25	taking	take	VBG
cord-322966-o65fo853	99	26	Entresto	Entresto	NNP
cord-322966-o65fo853	99	27	to	to	TO
cord-322966-o65fo853	99	28	report	report	VB
cord-322966-o65fo853	99	29	on	on	IN
cord-322966-o65fo853	99	30	the	the	DT
cord-322966-o65fo853	99	31	safety	safety	NN
cord-322966-o65fo853	99	32	of	of	IN
cord-322966-o65fo853	99	33	this	this	DT
cord-322966-o65fo853	99	34	drug	drug	NN
cord-322966-o65fo853	99	35	in	in	IN
cord-322966-o65fo853	99	36	COVID-19	COVID-19	NNP
cord-322966-o65fo853	99	37	[	[	-LRB-
cord-322966-o65fo853	99	38	10	10	CD
cord-322966-o65fo853	99	39	,	,	,
cord-322966-o65fo853	99	40	14	14	CD
cord-322966-o65fo853	99	41	,	,	,
cord-322966-o65fo853	99	42	22	22	CD
cord-322966-o65fo853	99	43	]	]	-RRB-
cord-322966-o65fo853	99	44	.	.	.
cord-322966-o65fo853	100	1	Reports	report	NNS
cord-322966-o65fo853	100	2	from	from	IN
cord-322966-o65fo853	100	3	China	China	NNP
cord-322966-o65fo853	100	4	showed	show	VBD
cord-322966-o65fo853	100	5	that	that	IN
cord-322966-o65fo853	100	6	patients	patient	NNS
cord-322966-o65fo853	100	7	with	with	IN
cord-322966-o65fo853	100	8	severe	severe	JJ
cord-322966-o65fo853	100	9	disease	disease	NN
cord-322966-o65fo853	100	10	,	,	,
cord-322966-o65fo853	100	11	leading	lead	VBG
cord-322966-o65fo853	100	12	to	to	IN
cord-322966-o65fo853	100	13	intensive	intensive	JJ
cord-322966-o65fo853	100	14	care	care	NN
cord-322966-o65fo853	100	15	unit	unit	NN
cord-322966-o65fo853	100	16	(	(	-LRB-
cord-322966-o65fo853	100	17	ICU	ICU	NNP
cord-322966-o65fo853	100	18	)	)	-RRB-
cord-322966-o65fo853	100	19	admission	admission	NN
cord-322966-o65fo853	100	20	and	and	CC
cord-322966-o65fo853	100	21	death	death	NN
cord-322966-o65fo853	100	22	,	,	,
cord-322966-o65fo853	100	23	had	have	VBD
cord-322966-o65fo853	100	24	features	feature	NNS
cord-322966-o65fo853	100	25	consistent	consistent	JJ
cord-322966-o65fo853	100	26	with	with	IN
cord-322966-o65fo853	100	27	unopposed	unopposed	JJ
cord-322966-o65fo853	100	28	RAS	RAS	NNP
cord-322966-o65fo853	100	29	activity	activity	NN
cord-322966-o65fo853	100	30	,	,	,
cord-322966-o65fo853	100	31	such	such	JJ
cord-322966-o65fo853	100	32	as	as	IN
cord-322966-o65fo853	100	33	higher	high	JJR
cord-322966-o65fo853	100	34	blood	blood	NN
cord-322966-o65fo853	100	35	pressure	pressure	NN
cord-322966-o65fo853	100	36	(	(	-LRB-
cord-322966-o65fo853	100	37	BP	BP	NNP
cord-322966-o65fo853	100	38	)	)	-RRB-
cord-322966-o65fo853	100	39	on	on	IN
cord-322966-o65fo853	100	40	admission	admission	NN
cord-322966-o65fo853	100	41	to	to	IN
cord-322966-o65fo853	100	42	hospital	hospital	NN
cord-322966-o65fo853	100	43	and	and	CC
cord-322966-o65fo853	100	44	higher	high	JJR
cord-322966-o65fo853	100	45	BP	BP	NNP
cord-322966-o65fo853	100	46	on	on	IN
cord-322966-o65fo853	100	47	admission	admission	NN
cord-322966-o65fo853	100	48	to	to	IN
cord-322966-o65fo853	100	49	ICU	ICU	NNP
cord-322966-o65fo853	100	50	in	in	IN
cord-322966-o65fo853	100	51	non	non	NNS
cord-322966-o65fo853	100	52	-	-	NNS
cord-322966-o65fo853	100	53	survivors	survivor	NNS
cord-322966-o65fo853	100	54	[	[	-LRB-
cord-322966-o65fo853	100	55	1	1	CD
cord-322966-o65fo853	100	56	,	,	,
cord-322966-o65fo853	100	57	35	35	CD
cord-322966-o65fo853	100	58	]	]	-RRB-
cord-322966-o65fo853	100	59	,	,	,
cord-322966-o65fo853	100	60	with	with	IN
cord-322966-o65fo853	100	61	a	a	DT
cord-322966-o65fo853	100	62	mean	mean	JJ
cord-322966-o65fo853	100	63	systolic	systolic	JJ
cord-322966-o65fo853	100	64	BP	BP	NNP
cord-322966-o65fo853	100	65	of	of	IN
cord-322966-o65fo853	100	66	145	145	CD
cord-322966-o65fo853	100	67	mmHg	mmHg	NNS
cord-322966-o65fo853	100	68	in	in	IN
cord-322966-o65fo853	100	69	those	those	DT
cord-322966-o65fo853	100	70	requiring	require	VBG
cord-322966-o65fo853	100	71	ICU	ICU	NNP
cord-322966-o65fo853	100	72	admission	admission	NN
cord-322966-o65fo853	100	73	versus	versus	IN
cord-322966-o65fo853	100	74	122	122	CD
cord-322966-o65fo853	100	75	mmHg	mmHg	NNS
cord-322966-o65fo853	100	76	in	in	IN
cord-322966-o65fo853	100	77	milder	mild	JJR
cord-322966-o65fo853	100	78	cases	case	NNS
cord-322966-o65fo853	100	79	(	(	-LRB-
cord-322966-o65fo853	100	80	p=0.018	p=0.018	NNP
cord-322966-o65fo853	100	81	)	)	-RRB-
cord-322966-o65fo853	101	1	[	[	-LRB-
cord-322966-o65fo853	101	2	35	35	CD
cord-322966-o65fo853	101	3	]	]	-RRB-
cord-322966-o65fo853	101	4	.	.	.
cord-322966-o65fo853	102	1	Lower	low	JJR
cord-322966-o65fo853	102	2	serum	serum	NN
cord-322966-o65fo853	102	3	potassium	potassium	NN
cord-322966-o65fo853	102	4	levels	level	NNS
cord-322966-o65fo853	102	5	,	,	,
cord-322966-o65fo853	102	6	combined	combine	VBN
cord-322966-o65fo853	102	7	with	with	IN
cord-322966-o65fo853	102	8	high	high	JJ
cord-322966-o65fo853	102	9	urinary	urinary	JJ
cord-322966-o65fo853	102	10	potassium	potassium	NN
cord-322966-o65fo853	102	11	has	have	VBZ
cord-322966-o65fo853	102	12	also	also	RB
cord-322966-o65fo853	102	13	been	be	VBN
cord-322966-o65fo853	102	14	reported	report	VBN
cord-322966-o65fo853	102	15	in	in	IN
cord-322966-o65fo853	102	16	more	more	JJR
cord-322966-o65fo853	102	17	severe	severe	JJ
cord-322966-o65fo853	102	18	patients	patient	NNS
cord-322966-o65fo853	102	19	[	[	-LRB-
cord-322966-o65fo853	102	20	39	39	CD
cord-322966-o65fo853	102	21	,	,	,
cord-322966-o65fo853	102	22	40	40	CD
cord-322966-o65fo853	102	23	]	]	-RRB-
cord-322966-o65fo853	102	24	,	,	,
cord-322966-o65fo853	102	25	suggesting	suggest	VBG
cord-322966-o65fo853	102	26	Ang	Ang	NNP
cord-322966-o65fo853	102	27	II	II	NNP
cord-322966-o65fo853	102	28	-	-	HYPH
cord-322966-o65fo853	102	29	mediated	mediate	VBN
cord-322966-o65fo853	102	30	activation	activation	NN
cord-322966-o65fo853	102	31	of	of	IN
cord-322966-o65fo853	102	32	aldosterone	aldosterone	NN
cord-322966-o65fo853	102	33	.	.	.
cord-322966-o65fo853	103	1	The	the	DT
cord-322966-o65fo853	103	2	presence	presence	NN
cord-322966-o65fo853	103	3	of	of	IN
cord-322966-o65fo853	103	4	significant	significant	JJ
cord-322966-o65fo853	103	5	hypertension	hypertension	NN
cord-322966-o65fo853	103	6	,	,	,
cord-322966-o65fo853	103	7	instead	instead	RB
cord-322966-o65fo853	103	8	of	of	IN
cord-322966-o65fo853	103	9	hypotension	hypotension	NN
cord-322966-o65fo853	103	10	,	,	,
cord-322966-o65fo853	103	11	in	in	IN
cord-322966-o65fo853	103	12	a	a	DT
cord-322966-o65fo853	103	13	group	group	NN
cord-322966-o65fo853	103	14	of	of	IN
cord-322966-o65fo853	103	15	patients	patient	NNS
cord-322966-o65fo853	103	16	admitted	admit	VBN
cord-322966-o65fo853	103	17	to	to	IN
cord-322966-o65fo853	103	18	ICU	ICU	NNP
cord-322966-o65fo853	103	19	versus	versus	IN
cord-322966-o65fo853	103	20	those	those	DT
cord-322966-o65fo853	103	21	not	not	RB
cord-322966-o65fo853	103	22	requiring	require	VBG
cord-322966-o65fo853	103	23	ICU	ICU	NNP
cord-322966-o65fo853	103	24	,	,	,
cord-322966-o65fo853	103	25	is	be	VBZ
cord-322966-o65fo853	103	26	a	a	DT
cord-322966-o65fo853	103	27	particularly	particularly	RB
cord-322966-o65fo853	103	28	interesting	interesting	JJ
cord-322966-o65fo853	103	29	clinical	clinical	JJ
cord-322966-o65fo853	103	30	finding	finding	NN
cord-322966-o65fo853	103	31	with	with	IN
cord-322966-o65fo853	103	32	implications	implication	NNS
cord-322966-o65fo853	103	33	for	for	IN
cord-322966-o65fo853	103	34	the	the	DT
cord-322966-o65fo853	103	35	pathogenesis	pathogenesis	NN
cord-322966-o65fo853	103	36	of	of	IN
cord-322966-o65fo853	103	37	COVID-19	COVID-19	NNP
cord-322966-o65fo853	103	38	.	.	.
cord-322966-o65fo853	104	1	Excess	excess	JJ
cord-322966-o65fo853	104	2	RAS	RAS	NNP
cord-322966-o65fo853	104	3	activity	activity	NN
cord-322966-o65fo853	104	4	without	without	IN
cord-322966-o65fo853	104	5	ACE-2	ACE-2	NNP
cord-322966-o65fo853	104	6	balance	balance	NN
cord-322966-o65fo853	104	7	to	to	TO
cord-322966-o65fo853	104	8	break	break	VB
cord-322966-o65fo853	104	9	down	down	RP
cord-322966-o65fo853	104	10	Ang	Ang	NNP
cord-322966-o65fo853	104	11	II	II	NNP
cord-322966-o65fo853	104	12	and	and	CC
cord-322966-o65fo853	104	13	block	block	VB
cord-322966-o65fo853	104	14	adverse	adverse	JJ
cord-322966-o65fo853	104	15	effects	effect	NNS
cord-322966-o65fo853	104	16	,	,	,
cord-322966-o65fo853	104	17	such	such	JJ
cord-322966-o65fo853	104	18	as	as	IN
cord-322966-o65fo853	104	19	cellular	cellular	JJ
cord-322966-o65fo853	104	20	damage	damage	NN
cord-322966-o65fo853	104	21	and	and	CC
cord-322966-o65fo853	104	22	fibrosis	fibrosis	NN
cord-322966-o65fo853	104	23	,	,	,
cord-322966-o65fo853	104	24	may	may	MD
cord-322966-o65fo853	104	25	play	play	VB
cord-322966-o65fo853	104	26	a	a	DT
cord-322966-o65fo853	104	27	key	key	JJ
cord-322966-o65fo853	104	28	role	role	NN
cord-322966-o65fo853	104	29	in	in	IN
cord-322966-o65fo853	104	30	determining	determine	VBG
cord-322966-o65fo853	104	31	disease	disease	NN
cord-322966-o65fo853	104	32	severity	severity	NN
cord-322966-o65fo853	104	33	,	,	,
cord-322966-o65fo853	104	34	similar	similar	JJ
cord-322966-o65fo853	104	35	to	to	IN
cord-322966-o65fo853	104	36	the	the	DT
cord-322966-o65fo853	104	37	RAS	RAS	NNP
cord-322966-o65fo853	104	38	pro	pro	JJ
cord-322966-o65fo853	104	39	-	-	JJ
cord-322966-o65fo853	104	40	inflammatory	inflammatory	JJ
cord-322966-o65fo853	104	41	effects	effect	NNS
cord-322966-o65fo853	104	42	well	well	RB
cord-322966-o65fo853	104	43	known	know	VBN
cord-322966-o65fo853	104	44	to	to	TO
cord-322966-o65fo853	104	45	contribute	contribute	VB
cord-322966-o65fo853	104	46	to	to	IN
cord-322966-o65fo853	104	47	heart	heart	NN
cord-322966-o65fo853	104	48	failure	failure	NN
cord-322966-o65fo853	104	49	(	(	-LRB-
cord-322966-o65fo853	104	50	Figure	figure	NN
cord-322966-o65fo853	104	51	2	2	CD
cord-322966-o65fo853	104	52	)	)	-RRB-
cord-322966-o65fo853	104	53	.	.	.
cord-322966-o65fo853	105	1	Autopsy	autopsy	JJ
cord-322966-o65fo853	105	2	data	datum	NNS
cord-322966-o65fo853	105	3	published	publish	VBN
cord-322966-o65fo853	105	4	for	for	IN
cord-322966-o65fo853	105	5	four	four	CD
cord-322966-o65fo853	105	6	COVID-19	covid-19	CD
cord-322966-o65fo853	105	7	patients	patient	NNS
cord-322966-o65fo853	105	8	[	[	-LRB-
cord-322966-o65fo853	105	9	41	41	CD
cord-322966-o65fo853	105	10	]	]	-RRB-
cord-322966-o65fo853	105	11	has	have	VBZ
cord-322966-o65fo853	105	12	described	describe	VBN
cord-322966-o65fo853	105	13	platelet	platelet	JJ
cord-322966-o65fo853	105	14	rich	rich	JJ
cord-322966-o65fo853	105	15	clot	clot	NN
cord-322966-o65fo853	105	16	formation	formation	NN
cord-322966-o65fo853	105	17	occluding	occlude	VBG
cord-322966-o65fo853	105	18	small	small	JJ
cord-322966-o65fo853	105	19	vessels	vessel	NNS
cord-322966-o65fo853	105	20	and	and	CC
cord-322966-o65fo853	105	21	a	a	DT
cord-322966-o65fo853	105	22	microangiopathic	microangiopathic	JJ
cord-322966-o65fo853	105	23	picture	picture	NN
cord-322966-o65fo853	105	24	,	,	,
cord-322966-o65fo853	105	25	consistent	consistent	JJ
cord-322966-o65fo853	105	26	with	with	IN
cord-322966-o65fo853	105	27	virally	virally	RB
cord-322966-o65fo853	105	28	mediated	mediate	VBN
cord-322966-o65fo853	105	29	vascular	vascular	JJ
cord-322966-o65fo853	105	30	damage	damage	NN
cord-322966-o65fo853	105	31	.	.	.
cord-322966-o65fo853	106	1	The	the	DT
cord-322966-o65fo853	106	2	ACE	ace	NN
cord-322966-o65fo853	106	3	:	:	:
cord-322966-o65fo853	107	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	107	2	Imbalance	imbalance	NN
cord-322966-o65fo853	107	3	Caused	cause	VBN
cord-322966-o65fo853	107	4	by	by	IN
cord-322966-o65fo853	108	1	Viral	Viral	NNP
cord-322966-o65fo853	108	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	108	3	Downregulation	Downregulation	NNP
cord-322966-o65fo853	108	4	Understanding	understand	VBG
cord-322966-o65fo853	108	5	the	the	DT
cord-322966-o65fo853	108	6	ACE	ace	NN
cord-322966-o65fo853	108	7	:	:	:
cord-322966-o65fo853	108	8	ACE-2	ACE-2	NNP
cord-322966-o65fo853	108	9	imbalance	imbalance	NN
cord-322966-o65fo853	108	10	in	in	IN
cord-322966-o65fo853	108	11	COVID-19	COVID-19	NNP
cord-322966-o65fo853	108	12	,	,	,
cord-322966-o65fo853	108	13	its	-PRON-	PRP$
cord-322966-o65fo853	108	14	role	role	NN
cord-322966-o65fo853	108	15	in	in	IN
cord-322966-o65fo853	108	16	age	age	NN
cord-322966-o65fo853	108	17	,	,	,
cord-322966-o65fo853	108	18	gender	gender	NN
cord-322966-o65fo853	108	19	and	and	CC
cord-322966-o65fo853	108	20	racial	racial	JJ
cord-322966-o65fo853	108	21	differences	difference	NNS
cord-322966-o65fo853	108	22	in	in	IN
cord-322966-o65fo853	108	23	disease	disease	NN
cord-322966-o65fo853	108	24	severity	severity	NN
cord-322966-o65fo853	108	25	,	,	,
cord-322966-o65fo853	108	26	and	and	CC
cord-322966-o65fo853	108	27	the	the	DT
cord-322966-o65fo853	108	28	difference	difference	NN
cord-322966-o65fo853	108	29	between	between	IN
cord-322966-o65fo853	108	30	tissue	tissue	NN
cord-322966-o65fo853	108	31	bound	bind	VBN
cord-322966-o65fo853	108	32	and	and	CC
cord-322966-o65fo853	108	33	circulating	circulate	VBG
cord-322966-o65fo853	108	34	ACE-2	ACE-2	NNP
cord-322966-o65fo853	109	1	,	,	,
cord-322966-o65fo853	109	2	could	could	MD
cord-322966-o65fo853	109	3	all	all	DT
cord-322966-o65fo853	109	4	prove	prove	VB
cord-322966-o65fo853	109	5	key	key	JJ
cord-322966-o65fo853	109	6	in	in	IN
cord-322966-o65fo853	109	7	treating	treat	VBG
cord-322966-o65fo853	109	8	this	this	DT
cord-322966-o65fo853	109	9	disease	disease	NN
cord-322966-o65fo853	109	10	.	.	.
cord-322966-o65fo853	110	1	In	in	IN
cord-322966-o65fo853	110	2	support	support	NN
cord-322966-o65fo853	110	3	of	of	IN
cord-322966-o65fo853	110	4	the	the	DT
cord-322966-o65fo853	110	5	fundamental	fundamental	JJ
cord-322966-o65fo853	110	6	ACE	ace	NN
cord-322966-o65fo853	110	7	:	:	:
cord-322966-o65fo853	111	1	ACE-2	ACE-2	NNP
cord-322966-o65fo853	111	2	imbalance	imbalance	NN
cord-322966-o65fo853	111	3	having	have	VBG
cord-322966-o65fo853	111	4	clinical	clinical	JJ
cord-322966-o65fo853	111	5	relevance	relevance	NN
cord-322966-o65fo853	111	6	,	,	,
cord-322966-o65fo853	111	7	it	-PRON-	PRP
cord-322966-o65fo853	111	8	has	have	VBZ
cord-322966-o65fo853	111	9	been	be	VBN
cord-322966-o65fo853	111	10	reported	report	VBN
cord-322966-o65fo853	111	11	that	that	IN
cord-322966-o65fo853	111	12	serum	serum	NN
cord-322966-o65fo853	111	13	Ang	Ang	NNP
cord-322966-o65fo853	111	14	II	II	NNP
cord-322966-o65fo853	111	15	levels	level	NNS
cord-322966-o65fo853	111	16	are	be	VBP
cord-322966-o65fo853	111	17	indeed	indeed	RB
cord-322966-o65fo853	111	18	significantly	significantly	RB
cord-322966-o65fo853	111	19	elevated	elevate	VBN
cord-322966-o65fo853	111	20	in	in	IN
cord-322966-o65fo853	111	21	COVID-19	COVID-19	NNP
cord-322966-o65fo853	111	22	and	and	CC
cord-322966-o65fo853	111	23	correlate	correlate	VB
cord-322966-o65fo853	111	24	with	with	IN
cord-322966-o65fo853	111	25	both	both	DT
cord-322966-o65fo853	111	26	viral	viral	JJ
cord-322966-o65fo853	111	27	load	load	NN
cord-322966-o65fo853	111	28	and	and	CC
cord-322966-o65fo853	111	29	lung	lung	NN
cord-322966-o65fo853	111	30	injury	injury	NN
cord-322966-o65fo853	111	31	[	[	-LRB-
cord-322966-o65fo853	111	32	42	42	CD
cord-322966-o65fo853	111	33	,	,	,
cord-322966-o65fo853	111	34	43	43	CD
cord-322966-o65fo853	111	35	]	]	-RRB-
cord-322966-o65fo853	111	36	.	.	.
cord-322966-o65fo853	112	1	Whilst	whilst	IN
cord-322966-o65fo853	112	2	ACE	ace	NN
cord-322966-o65fo853	112	3	formation	formation	NN
cord-322966-o65fo853	112	4	of	of	IN
cord-322966-o65fo853	112	5	Ang	Ang	NNP
cord-322966-o65fo853	112	6	II	II	NNP
cord-322966-o65fo853	112	7	can	can	MD
cord-322966-o65fo853	112	8	be	be	VB
cord-322966-o65fo853	112	9	blocked	block	VBN
cord-322966-o65fo853	112	10	by	by	IN
cord-322966-o65fo853	112	11	ACE	ACE	NNP
cord-322966-o65fo853	112	12	inhibitors	inhibitor	NNS
cord-322966-o65fo853	112	13	,	,	,
cord-322966-o65fo853	112	14	up	up	IN
cord-322966-o65fo853	112	15	to	to	TO
cord-322966-o65fo853	112	16	40	40	CD
cord-322966-o65fo853	112	17	%	%	NN
cord-322966-o65fo853	112	18	of	of	IN
cord-322966-o65fo853	112	19	Ang	Ang	NNP
cord-322966-o65fo853	112	20	II	II	NNP
cord-322966-o65fo853	112	21	is	be	VBZ
cord-322966-o65fo853	112	22	formed	form	VBN
cord-322966-o65fo853	112	23	via	via	IN
cord-322966-o65fo853	112	24	non	non	JJ
cord-322966-o65fo853	112	25	-	-	JJ
cord-322966-o65fo853	112	26	ACE	ace	JJ
cord-322966-o65fo853	112	27	pathways	pathway	NNS
cord-322966-o65fo853	112	28	such	such	JJ
cord-322966-o65fo853	112	29	as	as	IN
cord-322966-o65fo853	112	30	chymase	chymase	NNP
cord-322966-o65fo853	112	31	[	[	-LRB-
cord-322966-o65fo853	112	32	4	4	CD
cord-322966-o65fo853	112	33	]	]	-RRB-
cord-322966-o65fo853	112	34	,	,	,
cord-322966-o65fo853	112	35	making	make	VBG
cord-322966-o65fo853	112	36	ACE	ace	NN
cord-322966-o65fo853	112	37	inhibitors	inhibitor	NNS
cord-322966-o65fo853	112	38	potentially	potentially	RB
cord-322966-o65fo853	112	39	less	less	RBR
cord-322966-o65fo853	112	40	effective	effective	JJ
cord-322966-o65fo853	112	41	than	than	IN
cord-322966-o65fo853	112	42	ARB	ARB	NNP
cord-322966-o65fo853	112	43	blockers	blocker	NNS
cord-322966-o65fo853	112	44	in	in	IN
cord-322966-o65fo853	112	45	diminishing	diminish	VBG
cord-322966-o65fo853	112	46	the	the	DT
cord-322966-o65fo853	112	47	problem	problem	NN
cord-322966-o65fo853	112	48	of	of	IN
cord-322966-o65fo853	112	49	the	the	DT
cord-322966-o65fo853	112	50	excess	excess	JJ
cord-322966-o65fo853	112	51	Ang	Ang	NNP
cord-322966-o65fo853	112	52	II	II	NNP
cord-322966-o65fo853	112	53	,	,	,
cord-322966-o65fo853	112	54	since	since	IN
cord-322966-o65fo853	112	55	the	the	DT
cord-322966-o65fo853	112	56	ACEI	ACEI	NNP
cord-322966-o65fo853	112	57	may	may	MD
cord-322966-o65fo853	112	58	only	only	RB
cord-322966-o65fo853	112	59	block	block	VB
cord-322966-o65fo853	112	60	60	60	CD
cord-322966-o65fo853	112	61	%	%	NN
cord-322966-o65fo853	112	62	formation	formation	NN
cord-322966-o65fo853	112	63	of	of	IN
cord-322966-o65fo853	112	64	the	the	DT
cord-322966-o65fo853	112	65	Ang	Ang	NNP
cord-322966-o65fo853	112	66	II	II	NNP
cord-322966-o65fo853	112	67	.	.	.
cord-322966-o65fo853	113	1	On	on	IN
cord-322966-o65fo853	113	2	the	the	DT
cord-322966-o65fo853	113	3	other	other	JJ
cord-322966-o65fo853	113	4	hand	hand	NN
cord-322966-o65fo853	113	5	,	,	,
cord-322966-o65fo853	113	6	the	the	DT
cord-322966-o65fo853	113	7	ARBs	arb	NNS
cord-322966-o65fo853	113	8	are	be	VBP
cord-322966-o65fo853	113	9	highly	highly	RB
cord-322966-o65fo853	113	10	selective	selective	JJ
cord-322966-o65fo853	113	11	blockers	blocker	NNS
cord-322966-o65fo853	113	12	of	of	IN
cord-322966-o65fo853	113	13	the	the	DT
cord-322966-o65fo853	113	14	main	main	JJ
cord-322966-o65fo853	113	15	receptor	receptor	NN
cord-322966-o65fo853	113	16	for	for	IN
cord-322966-o65fo853	113	17	the	the	DT
cord-322966-o65fo853	113	18	Ang	Ang	NNP
cord-322966-o65fo853	113	19	II	II	NNP
cord-322966-o65fo853	113	20	,	,	,
cord-322966-o65fo853	113	21	the	the	DT
cord-322966-o65fo853	113	22	angiotensin	angiotensin	NN
cord-322966-o65fo853	113	23	receptor	receptor	NN
cord-322966-o65fo853	113	24	type	type	NN
cord-322966-o65fo853	113	25	1	1	CD
cord-322966-o65fo853	113	26	(	(	-LRB-
cord-322966-o65fo853	113	27	AT	at	IN
cord-322966-o65fo853	113	28	1	1	CD
cord-322966-o65fo853	113	29	)	)	-RRB-
cord-322966-o65fo853	113	30	receptor	receptor	NN
cord-322966-o65fo853	113	31	.	.	.
cord-322966-o65fo853	114	1	ARBs	arb	NNS
cord-322966-o65fo853	114	2	do	do	VBP
cord-322966-o65fo853	114	3	not	not	RB
cord-322966-o65fo853	114	4	decrease	decrease	VB
cord-322966-o65fo853	114	5	the	the	DT
cord-322966-o65fo853	114	6	amount	amount	NN
cord-322966-o65fo853	114	7	of	of	IN
cord-322966-o65fo853	114	8	Ang	Ang	NNP
cord-322966-o65fo853	114	9	II	II	NNP
cord-322966-o65fo853	114	10	produced	produce	VBN
cord-322966-o65fo853	114	11	in	in	IN
cord-322966-o65fo853	114	12	the	the	DT
cord-322966-o65fo853	114	13	first	first	JJ
cord-322966-o65fo853	114	14	place	place	NN
cord-322966-o65fo853	114	15	,	,	,
cord-322966-o65fo853	114	16	but	but	CC
cord-322966-o65fo853	114	17	by	by	IN
cord-322966-o65fo853	114	18	blocking	block	VBG
cord-322966-o65fo853	114	19	the	the	DT
cord-322966-o65fo853	114	20	AT	AT	NNP
cord-322966-o65fo853	114	21	1	1	CD
cord-322966-o65fo853	114	22	receptors	receptor	NNS
cord-322966-o65fo853	114	23	they	-PRON-	PRP
cord-322966-o65fo853	114	24	activate	activate	VBP
cord-322966-o65fo853	114	25	a	a	DT
cord-322966-o65fo853	114	26	key	key	JJ
cord-322966-o65fo853	114	27	counter	count	AFX
cord-322966-o65fo853	114	28	regulatory	regulatory	JJ
cord-322966-o65fo853	114	29	anti	anti	JJ
cord-322966-o65fo853	114	30	-	-	JJ
cord-322966-o65fo853	114	31	inflammatory	inflammatory	JJ
cord-322966-o65fo853	114	32	cascade	cascade	NN
cord-322966-o65fo853	114	33	to	to	TO
cord-322966-o65fo853	114	34	restore	restore	VB
cord-322966-o65fo853	114	35	the	the	DT
cord-322966-o65fo853	114	36	ACE	ace	NN
cord-322966-o65fo853	114	37	:	:	:
cord-322966-o65fo853	114	38	ACE-2	ACE-2	NNP
cord-322966-o65fo853	114	39	balance	balance	NN
cord-322966-o65fo853	114	40	.	.	.
cord-322966-o65fo853	115	1	The	the	DT
cord-322966-o65fo853	115	2	excessive	excessive	JJ
cord-322966-o65fo853	115	3	circulating	circulate	VBG
cord-322966-o65fo853	115	4	Ang	Ang	NNP
cord-322966-o65fo853	115	5	II	II	NNP
cord-322966-o65fo853	115	6	,	,	,
cord-322966-o65fo853	115	7	unable	unable	JJ
cord-322966-o65fo853	115	8	to	to	TO
cord-322966-o65fo853	115	9	bind	bind	VB
cord-322966-o65fo853	115	10	blocked	block	VBN
cord-322966-o65fo853	115	11	AT	at	IN
cord-322966-o65fo853	115	12	1	1	CD
cord-322966-o65fo853	115	13	receptors	receptor	NNS
cord-322966-o65fo853	115	14	,	,	,
cord-322966-o65fo853	115	15	binds	bind	VBZ
cord-322966-o65fo853	115	16	AT2	at2	NN
cord-322966-o65fo853	115	17	receptors	receptor	NNS
cord-322966-o65fo853	115	18	which	which	WDT
cord-322966-o65fo853	115	19	trigger	trigger	VBP
cord-322966-o65fo853	115	20	counter	counter	JJ
cord-322966-o65fo853	115	21	-	-	JJ
cord-322966-o65fo853	115	22	regulatory	regulatory	JJ
cord-322966-o65fo853	115	23	anti	anti	JJ
cord-322966-o65fo853	115	24	-	-	JJ
cord-322966-o65fo853	115	25	inflammatory	inflammatory	JJ
cord-322966-o65fo853	115	26	actions	action	NNS
cord-322966-o65fo853	115	27	and	and	CC
cord-322966-o65fo853	115	28	upregulates	upregulate	VBZ
cord-322966-o65fo853	115	29	ACE-2	ACE-2	NNP
cord-322966-o65fo853	115	30	expression	expression	NN
cord-322966-o65fo853	115	31	[	[	-LRB-
cord-322966-o65fo853	115	32	15	15	CD
cord-322966-o65fo853	115	33	]	]	-RRB-
cord-322966-o65fo853	115	34	to	to	TO
cord-322966-o65fo853	115	35	remove	remove	VB
cord-322966-o65fo853	115	36	excessive	excessive	JJ
cord-322966-o65fo853	115	37	circulating	circulate	VBG
cord-322966-o65fo853	115	38	Ang	Ang	NNP
cord-322966-o65fo853	115	39	II	II	NNP
cord-322966-o65fo853	115	40	.	.	.
cord-322966-o65fo853	116	1	A	a	DT
cord-322966-o65fo853	116	2	protective	protective	JJ
cord-322966-o65fo853	116	3	role	role	NN
cord-322966-o65fo853	116	4	of	of	IN
cord-322966-o65fo853	116	5	increased	increase	VBN
cord-322966-o65fo853	116	6	tissue	tissue	NN
cord-322966-o65fo853	116	7	ACE-2	ACE-2	NNP
cord-322966-o65fo853	116	8	expression	expression	NN
cord-322966-o65fo853	116	9	seems	seem	VBZ
cord-322966-o65fo853	116	10	plausible	plausible	JJ
cord-322966-o65fo853	116	11	since	since	IN
cord-322966-o65fo853	116	12	groups	group	NNS
cord-322966-o65fo853	116	13	with	with	IN
cord-322966-o65fo853	116	14	higher	high	JJR
cord-322966-o65fo853	116	15	levels	level	NNS
cord-322966-o65fo853	116	16	such	such	JJ
cord-322966-o65fo853	116	17	as	as	IN
cord-322966-o65fo853	116	18	younger	young	JJR
cord-322966-o65fo853	116	19	people	people	NNS
cord-322966-o65fo853	116	20	,	,	,
cord-322966-o65fo853	116	21	premenopausal	premenopausal	JJ
cord-322966-o65fo853	116	22	women	woman	NNS
cord-322966-o65fo853	116	23	and	and	CC
cord-322966-o65fo853	116	24	possibly	possibly	RB
cord-322966-o65fo853	116	25	Asian	asian	JJ
cord-322966-o65fo853	116	26	populations	population	NNS
cord-322966-o65fo853	116	27	[	[	-LRB-
cord-322966-o65fo853	116	28	8	8	CD
cord-322966-o65fo853	116	29	]	]	-RRB-
cord-322966-o65fo853	116	30	do	do	VBP
cord-322966-o65fo853	116	31	seem	seem	VB
cord-322966-o65fo853	116	32	to	to	TO
cord-322966-o65fo853	116	33	have	have	VB
cord-322966-o65fo853	116	34	lower	low	JJR
cord-322966-o65fo853	116	35	disease	disease	NN
cord-322966-o65fo853	116	36	severity	severity	NN
cord-322966-o65fo853	116	37	and	and	CC
cord-322966-o65fo853	116	38	mortality	mortality	NN
cord-322966-o65fo853	116	39	[	[	-LRB-
cord-322966-o65fo853	116	40	2	2	CD
cord-322966-o65fo853	116	41	,	,	,
cord-322966-o65fo853	116	42	9	9	CD
cord-322966-o65fo853	116	43	]	]	-RRB-
cord-322966-o65fo853	116	44	compared	compare	VBN
cord-322966-o65fo853	116	45	to	to	IN
cord-322966-o65fo853	116	46	European	european	JJ
cord-322966-o65fo853	116	47	populations	population	NNS
cord-322966-o65fo853	116	48	with	with	IN
cord-322966-o65fo853	116	49	an	an	DT
cord-322966-o65fo853	116	50	older	old	JJR
cord-322966-o65fo853	116	51	population	population	NN
cord-322966-o65fo853	116	52	and	and	CC
cord-322966-o65fo853	116	53	high	high	JJ
cord-322966-o65fo853	116	54	rates	rate	NNS
cord-322966-o65fo853	116	55	of	of	IN
cord-322966-o65fo853	116	56	co	co	NNS
cord-322966-o65fo853	116	57	-	-	NNS
cord-322966-o65fo853	116	58	morbidities	morbidity	NNS
cord-322966-o65fo853	116	59	such	such	JJ
cord-322966-o65fo853	116	60	as	as	IN
cord-322966-o65fo853	116	61	diabetes	diabetes	NN
cord-322966-o65fo853	116	62	,	,	,
cord-322966-o65fo853	116	63	hypertension	hypertension	NN
cord-322966-o65fo853	116	64	and	and	CC
cord-322966-o65fo853	116	65	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	116	66	disease	disease	NN
cord-322966-o65fo853	116	67	,	,	,
cord-322966-o65fo853	116	68	all	all	DT
cord-322966-o65fo853	116	69	of	of	IN
cord-322966-o65fo853	116	70	which	which	WDT
cord-322966-o65fo853	116	71	have	have	VBP
cord-322966-o65fo853	116	72	been	be	VBN
cord-322966-o65fo853	116	73	described	describe	VBN
cord-322966-o65fo853	116	74	as	as	IN
cord-322966-o65fo853	116	75	having	have	VBG
cord-322966-o65fo853	116	76	higher	high	JJR
cord-322966-o65fo853	116	77	circulating	circulate	VBG
cord-322966-o65fo853	116	78	ACE-2	ACE-2	NNP
cord-322966-o65fo853	116	79	levels	level	NNS
cord-322966-o65fo853	116	80	,	,	,
cord-322966-o65fo853	116	81	due	due	IN
cord-322966-o65fo853	116	82	to	to	IN
cord-322966-o65fo853	116	83	increased	increase	VBN
cord-322966-o65fo853	116	84	ACE-2	ACE-2	NNP
cord-322966-o65fo853	116	85	shedding	shed	VBG
cord-322966-o65fo853	116	86	.	.	.
cord-322966-o65fo853	117	1	It	-PRON-	PRP
cord-322966-o65fo853	117	2	has	have	VBZ
cord-322966-o65fo853	117	3	been	be	VBN
cord-322966-o65fo853	117	4	pointed	point	VBN
cord-322966-o65fo853	117	5	out	out	RP
cord-322966-o65fo853	117	6	that	that	IN
cord-322966-o65fo853	117	7	in	in	IN
cord-322966-o65fo853	117	8	another	another	DT
cord-322966-o65fo853	117	9	RNA	RNA	NNP
cord-322966-o65fo853	117	10	virus	virus	NN
cord-322966-o65fo853	117	11	,	,	,
cord-322966-o65fo853	117	12	human	human	JJ
cord-322966-o65fo853	117	13	immunodeficiency	immunodeficiency	NN
cord-322966-o65fo853	117	14	virus	virus	NN
cord-322966-o65fo853	117	15	(	(	-LRB-
cord-322966-o65fo853	117	16	HIV	HIV	NNP
cord-322966-o65fo853	117	17	)	)	-RRB-
cord-322966-o65fo853	117	18	,	,	,
cord-322966-o65fo853	117	19	higher	high	JJR
cord-322966-o65fo853	117	20	expression	expression	NN
cord-322966-o65fo853	117	21	of	of	IN
cord-322966-o65fo853	117	22	binding	bind	VBG
cord-322966-o65fo853	117	23	sites	site	NNS
cord-322966-o65fo853	117	24	such	such	JJ
cord-322966-o65fo853	117	25	as	as	IN
cord-322966-o65fo853	117	26	CD4	CD4	NNP
cord-322966-o65fo853	117	27	actually	actually	RB
cord-322966-o65fo853	117	28	protected	protect	VBD
cord-322966-o65fo853	117	29	from	from	IN
cord-322966-o65fo853	117	30	,	,	,
cord-322966-o65fo853	117	31	rather	rather	RB
cord-322966-o65fo853	117	32	than	than	IN
cord-322966-o65fo853	117	33	increased	increase	VBN
cord-322966-o65fo853	117	34	,	,	,
cord-322966-o65fo853	117	35	virulence	virulence	NN
cord-322966-o65fo853	117	36	[	[	-LRB-
cord-322966-o65fo853	117	37	15	15	CD
cord-322966-o65fo853	117	38	]	]	-RRB-
cord-322966-o65fo853	117	39	.	.	.
cord-322966-o65fo853	118	1	Males	male	NNS
cord-322966-o65fo853	118	2	have	have	VBP
cord-322966-o65fo853	118	3	only	only	RB
cord-322966-o65fo853	118	4	one	one	CD
cord-322966-o65fo853	118	5	X	x	NN
cord-322966-o65fo853	118	6	-	-	HYPH
cord-322966-o65fo853	118	7	linked	link	VBN
cord-322966-o65fo853	118	8	ACE-2	ACE-2	NNP
cord-322966-o65fo853	118	9	allele	allele	NN
cord-322966-o65fo853	118	10	and	and	CC
cord-322966-o65fo853	118	11	could	could	MD
cord-322966-o65fo853	118	12	be	be	VB
cord-322966-o65fo853	118	13	more	more	RBR
cord-322966-o65fo853	118	14	vulnerable	vulnerable	JJ
cord-322966-o65fo853	118	15	to	to	IN
cord-322966-o65fo853	118	16	phenotypes	phenotype	NNS
cord-322966-o65fo853	118	17	causing	cause	VBG
cord-322966-o65fo853	118	18	impaired	impair	VBN
cord-322966-o65fo853	118	19	ACE-2	ACE-2	NNP
cord-322966-o65fo853	118	20	regulation	regulation	NN
cord-322966-o65fo853	118	21	.	.	.
cord-322966-o65fo853	119	1	Patients	patient	NNS
cord-322966-o65fo853	119	2	with	with	IN
cord-322966-o65fo853	119	3	pre	pre	JJ
cord-322966-o65fo853	119	4	-	-	JJ
cord-322966-o65fo853	119	5	existing	existing	JJ
cord-322966-o65fo853	119	6	hypertension	hypertension	NN
cord-322966-o65fo853	119	7	may	may	MD
cord-322966-o65fo853	119	8	have	have	VB
cord-322966-o65fo853	119	9	a	a	DT
cord-322966-o65fo853	119	10	greater	great	JJR
cord-322966-o65fo853	119	11	frequency	frequency	NN
cord-322966-o65fo853	119	12	of	of	IN
cord-322966-o65fo853	119	13	the	the	DT
cord-322966-o65fo853	119	14	ACE	ace	NN
cord-322966-o65fo853	119	15	polymorphisms	polymorphism	NNS
cord-322966-o65fo853	119	16	that	that	WDT
cord-322966-o65fo853	119	17	result	result	VBP
cord-322966-o65fo853	119	18	in	in	IN
cord-322966-o65fo853	119	19	excessive	excessive	JJ
cord-322966-o65fo853	119	20	Ang	Ang	NNP
cord-322966-o65fo853	119	21	II	II	NNP
cord-322966-o65fo853	119	22	levels	level	NNS
cord-322966-o65fo853	119	23	,	,	,
cord-322966-o65fo853	119	24	exacerbated	exacerbate	VBN
cord-322966-o65fo853	119	25	by	by	IN
cord-322966-o65fo853	119	26	viral	viral	JJ
cord-322966-o65fo853	119	27	impairment	impairment	NN
cord-322966-o65fo853	119	28	of	of	IN
cord-322966-o65fo853	119	29	Ang	Ang	NNP
cord-322966-o65fo853	119	30	II	II	NNP
cord-322966-o65fo853	119	31	clearance	clearance	NN
cord-322966-o65fo853	119	32	.	.	.
cord-322966-o65fo853	120	1	COVID-19	COVID-19	NNP
cord-322966-o65fo853	120	2	is	be	VBZ
cord-322966-o65fo853	120	3	a	a	DT
cord-322966-o65fo853	120	4	disease	disease	NN
cord-322966-o65fo853	120	5	where	where	WRB
cord-322966-o65fo853	120	6	a	a	DT
cord-322966-o65fo853	120	7	major	major	JJ
cord-322966-o65fo853	120	8	battlefront	battlefront	NN
cord-322966-o65fo853	120	9	is	be	VBZ
cord-322966-o65fo853	120	10	at	at	IN
cord-322966-o65fo853	120	11	the	the	DT
cord-322966-o65fo853	120	12	endothelium	endothelium	NN
cord-322966-o65fo853	120	13	,	,	,
cord-322966-o65fo853	120	14	fought	fight	VBN
cord-322966-o65fo853	120	15	by	by	IN
cord-322966-o65fo853	120	16	the	the	DT
cord-322966-o65fo853	120	17	tissue	tissue	NN
cord-322966-o65fo853	120	18	RAS	RAS	NNP
cord-322966-o65fo853	120	19	.	.	.
cord-322966-o65fo853	121	1	There	there	EX
cord-322966-o65fo853	121	2	have	have	VBP
cord-322966-o65fo853	121	3	already	already	RB
cord-322966-o65fo853	121	4	been	be	VBN
cord-322966-o65fo853	121	5	cases	case	NNS
cord-322966-o65fo853	121	6	reported	report	VBN
cord-322966-o65fo853	121	7	in	in	IN
cord-322966-o65fo853	121	8	the	the	DT
cord-322966-o65fo853	121	9	media	medium	NNS
cord-322966-o65fo853	121	10	of	of	IN
cord-322966-o65fo853	121	11	families	family	NNS
cord-322966-o65fo853	121	12	tragically	tragically	RB
cord-322966-o65fo853	121	13	affected	affect	VBN
cord-322966-o65fo853	121	14	by	by	IN
cord-322966-o65fo853	121	15	very	very	RB
cord-322966-o65fo853	121	16	high	high	JJ
cord-322966-o65fo853	121	17	rates	rate	NNS
cord-322966-o65fo853	121	18	of	of	IN
cord-322966-o65fo853	121	19	severe	severe	JJ
cord-322966-o65fo853	121	20	disease	disease	NN
cord-322966-o65fo853	121	21	and	and	CC
cord-322966-o65fo853	121	22	mortality	mortality	NN
cord-322966-o65fo853	121	23	,	,	,
cord-322966-o65fo853	121	24	in	in	IN
cord-322966-o65fo853	121	25	line	line	NN
cord-322966-o65fo853	121	26	with	with	IN
cord-322966-o65fo853	121	27	genetic	genetic	JJ
cord-322966-o65fo853	121	28	factors	factor	NNS
cord-322966-o65fo853	121	29	playing	play	VBG
cord-322966-o65fo853	121	30	a	a	DT
cord-322966-o65fo853	121	31	significant	significant	JJ
cord-322966-o65fo853	121	32	role	role	NN
cord-322966-o65fo853	121	33	in	in	IN
cord-322966-o65fo853	121	34	COVID-19	covid-19	JJ
cord-322966-o65fo853	121	35	pathophysiology	pathophysiology	NN
cord-322966-o65fo853	121	36	[	[	-LRB-
cord-322966-o65fo853	121	37	44	44	CD
cord-322966-o65fo853	121	38	]	]	-RRB-
cord-322966-o65fo853	121	39	.	.	.
cord-322966-o65fo853	122	1	Coronaviruses	Coronaviruses	NNP
cord-322966-o65fo853	122	2	directly	directly	RB
cord-322966-o65fo853	122	3	impact	impact	VB
cord-322966-o65fo853	122	4	cellular	cellular	JJ
cord-322966-o65fo853	122	5	systems	system	NNS
cord-322966-o65fo853	122	6	,	,	,
cord-322966-o65fo853	122	7	other	other	JJ
cord-322966-o65fo853	122	8	than	than	IN
cord-322966-o65fo853	122	9	the	the	DT
cord-322966-o65fo853	122	10	RAS	RAS	NNP
cord-322966-o65fo853	122	11	,	,	,
cord-322966-o65fo853	122	12	which	which	WDT
cord-322966-o65fo853	122	13	are	be	VBP
cord-322966-o65fo853	122	14	important	important	JJ
cord-322966-o65fo853	122	15	in	in	IN
cord-322966-o65fo853	122	16	inflammatory	inflammatory	JJ
cord-322966-o65fo853	122	17	pathways	pathway	NNS
cord-322966-o65fo853	122	18	.	.	.
cord-322966-o65fo853	123	1	RNA	RNA	NNP
cord-322966-o65fo853	123	2	viruses	virus	NNS
cord-322966-o65fo853	123	3	remodel	remodel	VBP
cord-322966-o65fo853	123	4	host	host	NN
cord-322966-o65fo853	123	5	membranes	membrane	NNS
cord-322966-o65fo853	123	6	and	and	CC
cord-322966-o65fo853	123	7	lipid	lipid	NN
cord-322966-o65fo853	123	8	metabolism	metabolism	NN
cord-322966-o65fo853	123	9	creating	create	VBG
cord-322966-o65fo853	123	10	a	a	DT
cord-322966-o65fo853	123	11	suitable	suitable	JJ
cord-322966-o65fo853	123	12	environment	environment	NN
cord-322966-o65fo853	123	13	for	for	IN
cord-322966-o65fo853	123	14	their	-PRON-	PRP$
cord-322966-o65fo853	123	15	replication	replication	NN
cord-322966-o65fo853	123	16	[	[	-LRB-
cord-322966-o65fo853	123	17	45	45	CD
cord-322966-o65fo853	123	18	]	]	-RRB-
cord-322966-o65fo853	123	19	.	.	.
cord-322966-o65fo853	124	1	Lipid	lipid	NN
cord-322966-o65fo853	124	2	metabolism	metabolism	NN
cord-322966-o65fo853	124	3	pathways	pathway	NNS
cord-322966-o65fo853	124	4	are	be	VBP
cord-322966-o65fo853	124	5	impacted	impact	VBN
cord-322966-o65fo853	124	6	in	in	IN
cord-322966-o65fo853	124	7	corona	corona	NN
cord-322966-o65fo853	124	8	virus	virus	NN
cord-322966-o65fo853	124	9	infection	infection	NN
cord-322966-o65fo853	124	10	,	,	,
cord-322966-o65fo853	124	11	with	with	IN
cord-322966-o65fo853	124	12	glycerophospholipids	glycerophospholipid	NNS
cord-322966-o65fo853	124	13	and	and	CC
cord-322966-o65fo853	124	14	fatty	fatty	JJ
cord-322966-o65fo853	124	15	acids	acid	NNS
cord-322966-o65fo853	124	16	significantly	significantly	RB
cord-322966-o65fo853	124	17	elevated	elevate	VBN
cord-322966-o65fo853	124	18	in	in	IN
cord-322966-o65fo853	124	19	SARS	SARS	NNP
cord-322966-o65fo853	124	20	CoV-229E	CoV-229E	NNP
cord-322966-o65fo853	124	21	infected	infected	JJ
cord-322966-o65fo853	124	22	cells	cell	NNS
cord-322966-o65fo853	124	23	.	.	.
cord-322966-o65fo853	125	1	Up	up	RB
cord-322966-o65fo853	125	2	-	-	HYPH
cord-322966-o65fo853	125	3	regulated	regulated	JJ
cord-322966-o65fo853	125	4	phosphatidylinositol	phosphatidylinositol	NN
cord-322966-o65fo853	125	5	(	(	-LRB-
cord-322966-o65fo853	125	6	PI	pi	NN
cord-322966-o65fo853	125	7	)	)	-RRB-
cord-322966-o65fo853	125	8	may	may	MD
cord-322966-o65fo853	125	9	promote	promote	VB
cord-322966-o65fo853	125	10	coronavirus	coronavirus	NN
cord-322966-o65fo853	125	11	entry	entry	NN
cord-322966-o65fo853	125	12	[	[	-LRB-
cord-322966-o65fo853	125	13	46	46	CD
cord-322966-o65fo853	125	14	]	]	-RRB-
cord-322966-o65fo853	125	15	.	.	.
cord-322966-o65fo853	126	1	COVID-19	COVID-19	NNP
cord-322966-o65fo853	126	2	is	be	VBZ
cord-322966-o65fo853	126	3	associated	associate	VBN
cord-322966-o65fo853	126	4	with	with	IN
cord-322966-o65fo853	126	5	cardiac	cardiac	JJ
cord-322966-o65fo853	126	6	events	event	NNS
cord-322966-o65fo853	126	7	and	and	CC
cord-322966-o65fo853	126	8	significant	significant	JJ
cord-322966-o65fo853	126	9	serum	serum	NN
cord-322966-o65fo853	126	10	troponin	troponin	JJ
cord-322966-o65fo853	126	11	level	level	NN
cord-322966-o65fo853	126	12	elevation	elevation	NN
cord-322966-o65fo853	126	13	in	in	IN
cord-322966-o65fo853	126	14	a	a	DT
cord-322966-o65fo853	126	15	clinical	clinical	JJ
cord-322966-o65fo853	126	16	setting	setting	NN
cord-322966-o65fo853	126	17	[	[	-LRB-
cord-322966-o65fo853	126	18	36	36	CD
cord-322966-o65fo853	126	19	]	]	-RRB-
cord-322966-o65fo853	126	20	and	and	CC
cord-322966-o65fo853	126	21	elevated	elevated	JJ
cord-322966-o65fo853	126	22	lysophospholipids	lysophospholipid	NNS
cord-322966-o65fo853	126	23	,	,	,
cord-322966-o65fo853	126	24	including	include	VBG
cord-322966-o65fo853	126	25	LP1	LP1	NNP
cord-322966-o65fo853	126	26	,	,	,
cord-322966-o65fo853	126	27	have	have	VBP
cord-322966-o65fo853	126	28	been	be	VBN
cord-322966-o65fo853	126	29	reported	report	VBN
cord-322966-o65fo853	126	30	in	in	IN
cord-322966-o65fo853	126	31	acute	acute	JJ
cord-322966-o65fo853	126	32	coronary	coronary	JJ
cord-322966-o65fo853	126	33	syndromes	syndrome	NNS
cord-322966-o65fo853	126	34	from	from	IN
cord-322966-o65fo853	126	35	other	other	JJ
cord-322966-o65fo853	126	36	causes	cause	NNS
cord-322966-o65fo853	126	37	,	,	,
cord-322966-o65fo853	126	38	undergoing	undergo	VBG
cord-322966-o65fo853	126	39	coronary	coronary	JJ
cord-322966-o65fo853	126	40	angiography	angiography	NN
cord-322966-o65fo853	126	41	[	[	-LRB-
cord-322966-o65fo853	126	42	47	47	CD
cord-322966-o65fo853	126	43	]	]	-RRB-
cord-322966-o65fo853	126	44	.	.	.
cord-322966-o65fo853	127	1	HCoV-229E	HCoV-229E	NNP
cord-322966-o65fo853	127	2	infection	infection	NN
cord-322966-o65fo853	127	3	up	up	RB
cord-322966-o65fo853	127	4	-	-	HYPH
cord-322966-o65fo853	127	5	regulates	regulate	VBZ
cord-322966-o65fo853	127	6	fatty	fatty	JJ
cord-322966-o65fo853	127	7	acids	acid	NNS
cord-322966-o65fo853	127	8	,	,	,
cord-322966-o65fo853	127	9	believed	believe	VBD
cord-322966-o65fo853	127	10	to	to	TO
cord-322966-o65fo853	127	11	promote	promote	VB
cord-322966-o65fo853	127	12	efficient	efficient	JJ
cord-322966-o65fo853	127	13	coronavirus	coronavirus	NN
cord-322966-o65fo853	127	14	replication	replication	NN
cord-322966-o65fo853	127	15	.	.	.
cord-322966-o65fo853	128	1	However	however	RB
cord-322966-o65fo853	128	2	,	,	,
cord-322966-o65fo853	128	3	Yan	Yan	NNP
cord-322966-o65fo853	128	4	and	and	CC
cord-322966-o65fo853	128	5	co	co	NNS
cord-322966-o65fo853	128	6	-	-	NNS
cord-322966-o65fo853	128	7	workers	worker	NNS
cord-322966-o65fo853	128	8	[	[	-LRB-
cord-322966-o65fo853	128	9	46	46	CD
cord-322966-o65fo853	128	10	]	]	-RRB-
cord-322966-o65fo853	128	11	reported	report	VBD
cord-322966-o65fo853	128	12	that	that	IN
cord-322966-o65fo853	128	13	exogenous	exogenous	JJ
cord-322966-o65fo853	128	14	addition	addition	NN
cord-322966-o65fo853	128	15	of	of	IN
cord-322966-o65fo853	128	16	fatty	fatty	JJ
cord-322966-o65fo853	128	17	acids	acid	NNS
cord-322966-o65fo853	128	18	may	may	MD
cord-322966-o65fo853	128	19	interfere	interfere	VB
cord-322966-o65fo853	128	20	with	with	IN
cord-322966-o65fo853	128	21	viral	viral	JJ
cord-322966-o65fo853	128	22	replication	replication	NN
cord-322966-o65fo853	128	23	by	by	IN
cord-322966-o65fo853	128	24	upsetting	upset	VBG
cord-322966-o65fo853	128	25	the	the	DT
cord-322966-o65fo853	128	26	delicate	delicate	JJ
cord-322966-o65fo853	128	27	balance	balance	NN
cord-322966-o65fo853	128	28	of	of	IN
cord-322966-o65fo853	128	29	fatty	fatty	JJ
cord-322966-o65fo853	128	30	acids	acid	NNS
cord-322966-o65fo853	128	31	,	,	,
cord-322966-o65fo853	128	32	causing	cause	VBG
cord-322966-o65fo853	128	33	reversion	reversion	NN
cord-322966-o65fo853	128	34	of	of	IN
cord-322966-o65fo853	128	35	lysophospholipids	lysophospholipid	NNS
cord-322966-o65fo853	128	36	into	into	IN
cord-322966-o65fo853	128	37	phospholipids	phospholipid	NNS
cord-322966-o65fo853	128	38	,	,	,
cord-322966-o65fo853	128	39	limiting	limit	VBG
cord-322966-o65fo853	128	40	viral	viral	JJ
cord-322966-o65fo853	128	41	replication	replication	NN
cord-322966-o65fo853	128	42	.	.	.
cord-322966-o65fo853	129	1	It	-PRON-	PRP
cord-322966-o65fo853	129	2	is	be	VBZ
cord-322966-o65fo853	129	3	possible	possible	JJ
cord-322966-o65fo853	129	4	that	that	IN
cord-322966-o65fo853	129	5	the	the	DT
cord-322966-o65fo853	129	6	manipulation	manipulation	NN
cord-322966-o65fo853	129	7	of	of	IN
cord-322966-o65fo853	129	8	fatty	fatty	JJ
cord-322966-o65fo853	129	9	acids	acid	NNS
cord-322966-o65fo853	129	10	in	in	IN
cord-322966-o65fo853	129	11	a	a	DT
cord-322966-o65fo853	129	12	clinical	clinical	JJ
cord-322966-o65fo853	129	13	setting	setting	NN
cord-322966-o65fo853	129	14	may	may	MD
cord-322966-o65fo853	129	15	upset	upset	VB
cord-322966-o65fo853	129	16	the	the	DT
cord-322966-o65fo853	129	17	balance	balance	NN
cord-322966-o65fo853	129	18	needed	need	VBN
cord-322966-o65fo853	129	19	for	for	IN
cord-322966-o65fo853	129	20	viral	viral	JJ
cord-322966-o65fo853	129	21	replication	replication	NN
cord-322966-o65fo853	129	22	.	.	.
cord-322966-o65fo853	130	1	Use	use	NN
cord-322966-o65fo853	130	2	of	of	IN
cord-322966-o65fo853	130	3	drugs	drug	NNS
cord-322966-o65fo853	130	4	such	such	JJ
cord-322966-o65fo853	130	5	as	as	IN
cord-322966-o65fo853	130	6	statins	statin	NNS
cord-322966-o65fo853	130	7	may	may	MD
cord-322966-o65fo853	130	8	also	also	RB
cord-322966-o65fo853	130	9	impact	impact	VB
cord-322966-o65fo853	130	10	viral	viral	JJ
cord-322966-o65fo853	130	11	ability	ability	NN
cord-322966-o65fo853	130	12	to	to	TO
cord-322966-o65fo853	130	13	harness	harness	VB
cord-322966-o65fo853	130	14	cellular	cellular	JJ
cord-322966-o65fo853	130	15	lipid	lipid	NN
cord-322966-o65fo853	130	16	pathways	pathway	NNS
cord-322966-o65fo853	130	17	.	.	.
cord-322966-o65fo853	131	1	Clearly	clearly	RB
cord-322966-o65fo853	131	2	more	more	JJR
cord-322966-o65fo853	131	3	data	datum	NNS
cord-322966-o65fo853	131	4	is	be	VBZ
cord-322966-o65fo853	131	5	needed	need	VBN
cord-322966-o65fo853	131	6	to	to	TO
cord-322966-o65fo853	131	7	investigate	investigate	VB
cord-322966-o65fo853	131	8	the	the	DT
cord-322966-o65fo853	131	9	role	role	NN
cord-322966-o65fo853	131	10	of	of	IN
cord-322966-o65fo853	131	11	fatty	fatty	JJ
cord-322966-o65fo853	131	12	acid	acid	NN
cord-322966-o65fo853	131	13	and	and	CC
cord-322966-o65fo853	131	14	cholesterol	cholesterol	NN
cord-322966-o65fo853	131	15	manipulation	manipulation	NN
cord-322966-o65fo853	131	16	.	.	.
cord-322966-o65fo853	132	1	The	the	DT
cord-322966-o65fo853	132	2	finding	finding	NN
cord-322966-o65fo853	132	3	that	that	IN
cord-322966-o65fo853	132	4	statins	statin	NNS
cord-322966-o65fo853	132	5	decrease	decrease	VBP
cord-322966-o65fo853	132	6	in	in	IN
cord-322966-o65fo853	132	7	-	-	HYPH
cord-322966-o65fo853	132	8	hospital	hospital	NN
cord-322966-o65fo853	132	9	mortality	mortality	NN
cord-322966-o65fo853	132	10	,	,	,
cord-322966-o65fo853	132	11	even	even	RB
cord-322966-o65fo853	132	12	in	in	IN
cord-322966-o65fo853	132	13	a	a	DT
cord-322966-o65fo853	132	14	non	non	JJ
cord-322966-o65fo853	132	15	-	-	JJ
cord-322966-o65fo853	132	16	randomised	randomised	JJ
cord-322966-o65fo853	132	17	study	study	NN
cord-322966-o65fo853	132	18	[	[	-LRB-
cord-322966-o65fo853	132	19	10	10	CD
cord-322966-o65fo853	132	20	]	]	-RRB-
cord-322966-o65fo853	132	21	,	,	,
cord-322966-o65fo853	132	22	is	be	VBZ
cord-322966-o65fo853	132	23	of	of	IN
cord-322966-o65fo853	132	24	interest	interest	NN
cord-322966-o65fo853	132	25	.	.	.
cord-322966-o65fo853	133	1	Long	long	JJ
cord-322966-o65fo853	133	2	term	term	NN
cord-322966-o65fo853	133	3	sequelae	sequela	NNS
cord-322966-o65fo853	133	4	of	of	IN
cord-322966-o65fo853	133	5	SARS	SARS	NNP
cord-322966-o65fo853	133	6	,	,	,
cord-322966-o65fo853	133	7	caused	cause	VBN
cord-322966-o65fo853	133	8	by	by	IN
cord-322966-o65fo853	133	9	a	a	DT
cord-322966-o65fo853	133	10	related	related	JJ
cord-322966-o65fo853	133	11	coronavirus	coronavirus	NN
cord-322966-o65fo853	133	12	(	(	-LRB-
cord-322966-o65fo853	133	13	SARS	SARS	NNP
cord-322966-o65fo853	133	14	Co	Co	NNP
cord-322966-o65fo853	133	15	-	-	HYPH
cord-322966-o65fo853	133	16	V	V	NNP
cord-322966-o65fo853	133	17	)	)	-RRB-
cord-322966-o65fo853	133	18	,	,	,
cord-322966-o65fo853	133	19	have	have	VBP
cord-322966-o65fo853	133	20	been	be	VBN
cord-322966-o65fo853	133	21	reported	report	VBN
cord-322966-o65fo853	133	22	in	in	IN
cord-322966-o65fo853	133	23	follow	follow	NN
cord-322966-o65fo853	133	24	-	-	HYPH
cord-322966-o65fo853	133	25	up	up	NN
cord-322966-o65fo853	133	26	studies	study	NNS
cord-322966-o65fo853	133	27	in	in	IN
cord-322966-o65fo853	133	28	survivors	survivor	NNS
cord-322966-o65fo853	133	29	out	out	IN
cord-322966-o65fo853	133	30	to	to	TO
cord-322966-o65fo853	133	31	15	15	CD
cord-322966-o65fo853	133	32	years	year	NNS
cord-322966-o65fo853	133	33	.	.	.
cord-322966-o65fo853	134	1	These	these	DT
cord-322966-o65fo853	134	2	include	include	VBP
cord-322966-o65fo853	134	3	sleep	sleep	NN
cord-322966-o65fo853	134	4	disturbance	disturbance	NN
cord-322966-o65fo853	134	5	,	,	,
cord-322966-o65fo853	134	6	characterised	characterise	VBN
cord-322966-o65fo853	134	7	by	by	IN
cord-322966-o65fo853	134	8	increased	increase	VBN
cord-322966-o65fo853	134	9	stage	stage	NN
cord-322966-o65fo853	134	10	2	2	CD
cord-322966-o65fo853	134	11	sleep	sleep	NN
cord-322966-o65fo853	134	12	percentage	percentage	NN
cord-322966-o65fo853	134	13	,	,	,
cord-322966-o65fo853	134	14	diffuse	diffuse	JJ
cord-322966-o65fo853	134	15	myalgia	myalgia	NN
cord-322966-o65fo853	134	16	,	,	,
cord-322966-o65fo853	134	17	chronic	chronic	JJ
cord-322966-o65fo853	134	18	fatigue	fatigue	NN
cord-322966-o65fo853	134	19	,	,	,
cord-322966-o65fo853	134	20	depression	depression	NN
cord-322966-o65fo853	134	21	,	,	,
cord-322966-o65fo853	134	22	lung	lung	NN
cord-322966-o65fo853	134	23	damage	damage	NN
cord-322966-o65fo853	134	24	and	and	CC
cord-322966-o65fo853	134	25	avascular	avascular	JJ
cord-322966-o65fo853	134	26	femoral	femoral	JJ
cord-322966-o65fo853	134	27	head	head	NN
cord-322966-o65fo853	134	28	necrosis	necrosis	NN
cord-322966-o65fo853	134	29	[	[	-LRB-
cord-322966-o65fo853	134	30	48	48	CD
cord-322966-o65fo853	134	31	]	]	-RRB-
cord-322966-o65fo853	135	1	[	[	-LRB-
cord-322966-o65fo853	135	2	49	49	CD
cord-322966-o65fo853	135	3	]	]	-RRB-
cord-322966-o65fo853	135	4	[	[	-LRB-
cord-322966-o65fo853	135	5	50	50	CD
cord-322966-o65fo853	135	6	]	]	-RRB-
cord-322966-o65fo853	135	7	.	.	.
cord-322966-o65fo853	136	1	Deranged	deranged	JJ
cord-322966-o65fo853	136	2	lipid	lipid	NN
cord-322966-o65fo853	136	3	metabolism	metabolism	NN
cord-322966-o65fo853	136	4	has	have	VBZ
cord-322966-o65fo853	136	5	also	also	RB
cord-322966-o65fo853	136	6	been	be	VBN
cord-322966-o65fo853	136	7	reported	report	VBN
cord-322966-o65fo853	136	8	in	in	IN
cord-322966-o65fo853	136	9	SARS	SARS	NNP
cord-322966-o65fo853	136	10	survivors	survivor	NNS
cord-322966-o65fo853	136	11	.	.	.
cord-322966-o65fo853	137	1	Lipid	lipid	NN
cord-322966-o65fo853	137	2	metabolites	metabolite	NNS
cord-322966-o65fo853	137	3	,	,	,
cord-322966-o65fo853	137	4	including	include	VBG
cord-322966-o65fo853	137	5	phosphatidylinositol	phosphatidylinositol	JJ
cord-322966-o65fo853	137	6	(	(	-LRB-
cord-322966-o65fo853	137	7	PI	PI	NNP
cord-322966-o65fo853	137	8	)	)	-RRB-
cord-322966-o65fo853	137	9	and	and	CC
cord-322966-o65fo853	137	10	lysophosphatidylinositol	lysophosphatidylinositol	NNP
cord-322966-o65fo853	137	11	(	(	-LRB-
cord-322966-o65fo853	137	12	LPI	LPI	NNP
cord-322966-o65fo853	137	13	)	)	-RRB-
cord-322966-o65fo853	137	14	,	,	,
cord-322966-o65fo853	137	15	are	be	VBP
cord-322966-o65fo853	137	16	associated	associate	VBN
cord-322966-o65fo853	137	17	with	with	IN
cord-322966-o65fo853	137	18	cellular	cellular	JJ
cord-322966-o65fo853	137	19	entry	entry	NN
cord-322966-o65fo853	137	20	and/or	and/or	CC
cord-322966-o65fo853	137	21	egress	egress	NN
cord-322966-o65fo853	137	22	of	of	IN
cord-322966-o65fo853	137	23	respiratory	respiratory	JJ
cord-322966-o65fo853	137	24	viruses	virus	NNS
cord-322966-o65fo853	137	25	.	.	.
cord-322966-o65fo853	138	1	LPIs	LPIs	NNP
cord-322966-o65fo853	138	2	and	and	CC
cord-322966-o65fo853	138	3	PIs	pi	NNS
cord-322966-o65fo853	138	4	were	be	VBD
cord-322966-o65fo853	138	5	markedly	markedly	RB
cord-322966-o65fo853	138	6	upregulated	upregulate	VBN
cord-322966-o65fo853	138	7	in	in	IN
cord-322966-o65fo853	138	8	recovered	recover	VBN
cord-322966-o65fo853	138	9	SARS	SARS	NNP
cord-322966-o65fo853	138	10	patients	patient	NNS
cord-322966-o65fo853	138	11	.	.	.
cord-322966-o65fo853	139	1	LPIs	lpi	NNS
cord-322966-o65fo853	139	2	are	be	VBP
cord-322966-o65fo853	139	3	thought	think	VBN
cord-322966-o65fo853	139	4	to	to	TO
cord-322966-o65fo853	139	5	have	have	VB
cord-322966-o65fo853	139	6	a	a	DT
cord-322966-o65fo853	139	7	critical	critical	JJ
cord-322966-o65fo853	139	8	role	role	NN
cord-322966-o65fo853	139	9	in	in	IN
cord-322966-o65fo853	139	10	glucose	glucose	NN
cord-322966-o65fo853	139	11	homeostasis	homeostasis	NN
cord-322966-o65fo853	139	12	.	.	.
cord-322966-o65fo853	140	1	A	a	DT
cord-322966-o65fo853	140	2	large	large	JJ
cord-322966-o65fo853	140	3	proportion	proportion	NN
cord-322966-o65fo853	140	4	of	of	IN
cord-322966-o65fo853	140	5	the	the	DT
cord-322966-o65fo853	140	6	recovered	recover	VBN
cord-322966-o65fo853	140	7	SARS	SARS	NNP
cord-322966-o65fo853	140	8	patients	patient	NNS
cord-322966-o65fo853	140	9	reported	report	VBD
cord-322966-o65fo853	140	10	glucose	glucose	NN
cord-322966-o65fo853	140	11	metabolic	metabolic	JJ
cord-322966-o65fo853	140	12	disorders	disorder	NNS
cord-322966-o65fo853	140	13	,	,	,
cord-322966-o65fo853	140	14	including	include	VBG
cord-322966-o65fo853	140	15	hyperinsulinaemia	hyperinsulinaemia	NN
cord-322966-o65fo853	140	16	,	,	,
cord-322966-o65fo853	140	17	insulin	insulin	NN
cord-322966-o65fo853	140	18	resistance	resistance	NN
cord-322966-o65fo853	140	19	,	,	,
cord-322966-o65fo853	140	20	hyperglycaemia	hyperglycaemia	NN
cord-322966-o65fo853	140	21	,	,	,
cord-322966-o65fo853	140	22	and	and	CC
cord-322966-o65fo853	140	23	type	type	NN
cord-322966-o65fo853	140	24	1	1	CD
cord-322966-o65fo853	140	25	or	or	CC
cord-322966-o65fo853	140	26	2	2	CD
cord-322966-o65fo853	140	27	diabetes	diabete	NNS
cord-322966-o65fo853	140	28	[	[	-LRB-
cord-322966-o65fo853	140	29	49	49	CD
cord-322966-o65fo853	140	30	]	]	-RRB-
cord-322966-o65fo853	140	31	.	.	.
cord-322966-o65fo853	141	1	Patients	patient	NNS
cord-322966-o65fo853	141	2	who	who	WP
cord-322966-o65fo853	141	3	died	die	VBD
cord-322966-o65fo853	141	4	of	of	IN
cord-322966-o65fo853	141	5	SARS	SARS	NNP
cord-322966-o65fo853	141	6	were	be	VBD
cord-322966-o65fo853	141	7	found	find	VBN
cord-322966-o65fo853	141	8	to	to	TO
cord-322966-o65fo853	141	9	have	have	VB
cord-322966-o65fo853	141	10	extensive	extensive	JJ
cord-322966-o65fo853	141	11	lung	lung	NN
cord-322966-o65fo853	141	12	damage	damage	NN
cord-322966-o65fo853	141	13	as	as	RB
cord-322966-o65fo853	141	14	well	well	RB
cord-322966-o65fo853	141	15	as	as	IN
cord-322966-o65fo853	141	16	features	feature	NNS
cord-322966-o65fo853	141	17	of	of	IN
cord-322966-o65fo853	141	18	systemic	systemic	JJ
cord-322966-o65fo853	141	19	vasculitis	vasculitis	NN
cord-322966-o65fo853	141	20	.	.	.
cord-322966-o65fo853	142	1	Autoantibodies	Autoantibodies	NNP
cord-322966-o65fo853	142	2	against	against	IN
cord-322966-o65fo853	142	3	human	human	JJ
cord-322966-o65fo853	142	4	epithelial	epithelial	NN
cord-322966-o65fo853	142	5	and	and	CC
cord-322966-o65fo853	142	6	endothelial	endothelial	JJ
cord-322966-o65fo853	142	7	cells	cell	NNS
cord-322966-o65fo853	142	8	can	can	MD
cord-322966-o65fo853	142	9	develop	develop	VB
cord-322966-o65fo853	142	10	after	after	IN
cord-322966-o65fo853	142	11	SARS	SARS	NNP
cord-322966-o65fo853	142	12	-	-	HYPH
cord-322966-o65fo853	142	13	CoV	CoV	NNP
cord-322966-o65fo853	142	14	infection	infection	NN
cord-322966-o65fo853	142	15	and	and	CC
cord-322966-o65fo853	142	16	this	this	DT
cord-322966-o65fo853	142	17	could	could	MD
cord-322966-o65fo853	142	18	explain	explain	VB
cord-322966-o65fo853	142	19	the	the	DT
cord-322966-o65fo853	142	20	severe	severe	JJ
cord-322966-o65fo853	142	21	deterioration	deterioration	NN
cord-322966-o65fo853	142	22	in	in	IN
cord-322966-o65fo853	142	23	some	some	DT
cord-322966-o65fo853	142	24	patients	patient	NNS
cord-322966-o65fo853	142	25	in	in	IN
cord-322966-o65fo853	142	26	phase	phase	NN
cord-322966-o65fo853	142	27	II	ii	CD
cord-322966-o65fo853	142	28	of	of	IN
cord-322966-o65fo853	142	29	the	the	DT
cord-322966-o65fo853	142	30	disease	disease	NN
cord-322966-o65fo853	142	31	and	and	CC
cord-322966-o65fo853	142	32	may	may	MD
cord-322966-o65fo853	142	33	lead	lead	VB
cord-322966-o65fo853	142	34	to	to	IN
cord-322966-o65fo853	142	35	post	post	JJ
cord-322966-o65fo853	142	36	-	-	JJ
cord-322966-o65fo853	142	37	infectious	infectious	JJ
cord-322966-o65fo853	142	38	cellular	cellular	JJ
cord-322966-o65fo853	142	39	injury	injury	NN
cord-322966-o65fo853	142	40	and	and	CC
cord-322966-o65fo853	142	41	SARS	SARS	NNP
cord-322966-o65fo853	142	42	-	-	HYPH
cord-322966-o65fo853	142	43	induced	induce	VBN
cord-322966-o65fo853	142	44	immunopathology	immunopathology	NN
cord-322966-o65fo853	142	45	in	in	IN
cord-322966-o65fo853	142	46	survivors	survivor	NNS
cord-322966-o65fo853	142	47	[	[	-LRB-
cord-322966-o65fo853	142	48	51	51	CD
cord-322966-o65fo853	142	49	]	]	-RRB-
cord-322966-o65fo853	142	50	.	.	.
cord-322966-o65fo853	143	1	This	this	DT
cord-322966-o65fo853	143	2	long	long	JJ
cord-322966-o65fo853	143	3	-	-	HYPH
cord-322966-o65fo853	143	4	term	term	NN
cord-322966-o65fo853	143	5	immunopathology	immunopathology	NN
cord-322966-o65fo853	143	6	could	could	MD
cord-322966-o65fo853	143	7	also	also	RB
cord-322966-o65fo853	143	8	be	be	VB
cord-322966-o65fo853	143	9	a	a	DT
cord-322966-o65fo853	143	10	risk	risk	NN
cord-322966-o65fo853	143	11	in	in	IN
cord-322966-o65fo853	143	12	COVID-19	COVID-19	NNP
cord-322966-o65fo853	143	13	,	,	,
cord-322966-o65fo853	143	14	a	a	DT
cord-322966-o65fo853	143	15	related	related	JJ
cord-322966-o65fo853	143	16	virus	virus	NN
cord-322966-o65fo853	143	17	which	which	WDT
cord-322966-o65fo853	143	18	also	also	RB
cord-322966-o65fo853	143	19	acts	act	VBZ
cord-322966-o65fo853	143	20	to	to	TO
cord-322966-o65fo853	143	21	inflame	inflame	VB
cord-322966-o65fo853	143	22	the	the	DT
cord-322966-o65fo853	143	23	endothelium	endothelium	NN
cord-322966-o65fo853	143	24	and	and	CC
cord-322966-o65fo853	143	25	,	,	,
cord-322966-o65fo853	143	26	due	due	IN
cord-322966-o65fo853	143	27	to	to	IN
cord-322966-o65fo853	143	28	gender	gender	NN
cord-322966-o65fo853	143	29	differences	difference	NNS
cord-322966-o65fo853	143	30	in	in	IN
cord-322966-o65fo853	143	31	immune	immune	JJ
cord-322966-o65fo853	143	32	function	function	NN
cord-322966-o65fo853	143	33	,	,	,
cord-322966-o65fo853	143	34	female	female	JJ
cord-322966-o65fo853	143	35	survivors	survivor	NNS
cord-322966-o65fo853	143	36	may	may	MD
cord-322966-o65fo853	143	37	be	be	VB
cord-322966-o65fo853	143	38	at	at	IN
cord-322966-o65fo853	143	39	greater	great	JJR
cord-322966-o65fo853	143	40	risk	risk	NN
cord-322966-o65fo853	143	41	to	to	IN
cord-322966-o65fo853	143	42	autoimmune	autoimmune	JJ
cord-322966-o65fo853	143	43	mediated	mediate	VBN
cord-322966-o65fo853	143	44	sequelae	sequela	NNS
cord-322966-o65fo853	143	45	[	[	-LRB-
cord-322966-o65fo853	143	46	33	33	CD
cord-322966-o65fo853	143	47	]	]	-RRB-
cord-322966-o65fo853	143	48	.	.	.
cord-322966-o65fo853	144	1	Immune	immune	JJ
cord-322966-o65fo853	144	2	System	system	NN
cord-322966-o65fo853	144	3	Role	role	NN
cord-322966-o65fo853	144	4	of	of	IN
cord-322966-o65fo853	144	5	Vitamin	vitamin	NN
cord-322966-o65fo853	144	6	D	d	NN
cord-322966-o65fo853	144	7	and	and	CC
cord-322966-o65fo853	144	8	ACE	ace	NN
cord-322966-o65fo853	144	9	Vitamin	vitamin	NN
cord-322966-o65fo853	144	10	D	d	NN
cord-322966-o65fo853	144	11	deficiency	deficiency	NN
cord-322966-o65fo853	144	12	can	can	MD
cord-322966-o65fo853	144	13	be	be	VB
cord-322966-o65fo853	144	14	related	relate	VBN
cord-322966-o65fo853	144	15	to	to	IN
cord-322966-o65fo853	144	16	immune	immune	JJ
cord-322966-o65fo853	144	17	system	system	NN
cord-322966-o65fo853	144	18	dysfunction	dysfunction	NN
cord-322966-o65fo853	144	19	[	[	-LRB-
cord-322966-o65fo853	144	20	18	18	CD
cord-322966-o65fo853	144	21	]	]	-RRB-
cord-322966-o65fo853	144	22	and	and	CC
cord-322966-o65fo853	144	23	inflammation	inflammation	NN
cord-322966-o65fo853	144	24	,	,	,
cord-322966-o65fo853	144	25	and	and	CC
cord-322966-o65fo853	144	26	can	can	MD
cord-322966-o65fo853	144	27	cause	cause	VB
cord-322966-o65fo853	144	28	a	a	DT
cord-322966-o65fo853	144	29	pro	pro	JJ
cord-322966-o65fo853	144	30	-	-	JJ
cord-322966-o65fo853	144	31	thrombotic	thrombotic	JJ
cord-322966-o65fo853	144	32	state	state	NN
cord-322966-o65fo853	144	33	;	;	:
cord-322966-o65fo853	144	34	it	-PRON-	PRP
cord-322966-o65fo853	144	35	is	be	VBZ
cord-322966-o65fo853	144	36	common	common	JJ
cord-322966-o65fo853	144	37	in	in	IN
cord-322966-o65fo853	144	38	Europe	Europe	NNP
cord-322966-o65fo853	144	39	in	in	IN
cord-322966-o65fo853	144	40	winter	winter	NN
cord-322966-o65fo853	144	41	.	.	.
cord-322966-o65fo853	145	1	Vitamin	vitamin	NN
cord-322966-o65fo853	145	2	D	d	NN
cord-322966-o65fo853	145	3	is	be	VBZ
cord-322966-o65fo853	145	4	a	a	DT
cord-322966-o65fo853	145	5	potent	potent	JJ
cord-322966-o65fo853	145	6	negative	negative	JJ
cord-322966-o65fo853	145	7	endocrine	endocrine	JJ
cord-322966-o65fo853	145	8	regulator	regulator	NN
cord-322966-o65fo853	145	9	of	of	IN
cord-322966-o65fo853	145	10	the	the	DT
cord-322966-o65fo853	145	11	RAS	RAS	NNP
cord-322966-o65fo853	145	12	and	and	CC
cord-322966-o65fo853	145	13	works	work	VBZ
cord-322966-o65fo853	145	14	predominantly	predominantly	RB
cord-322966-o65fo853	145	15	by	by	IN
cord-322966-o65fo853	145	16	suppressing	suppress	VBG
cord-322966-o65fo853	145	17	renin	renin	NN
cord-322966-o65fo853	145	18	synthesis	synthesis	NN
cord-322966-o65fo853	145	19	[	[	-LRB-
cord-322966-o65fo853	145	20	52	52	CD
cord-322966-o65fo853	145	21	]	]	-RRB-
cord-322966-o65fo853	145	22	.	.	.
cord-322966-o65fo853	146	1	Vitamin	vitamin	NN
cord-322966-o65fo853	146	2	D	d	NN
cord-322966-o65fo853	146	3	deficiency	deficiency	NN
cord-322966-o65fo853	146	4	and	and	CC
cord-322966-o65fo853	146	5	genetic	genetic	JJ
cord-322966-o65fo853	146	6	and	and	CC
cord-322966-o65fo853	146	7	geographical	geographical	JJ
cord-322966-o65fo853	146	8	variation	variation	NN
cord-322966-o65fo853	146	9	in	in	IN
cord-322966-o65fo853	146	10	its	-PRON-	PRP$
cord-322966-o65fo853	146	11	function	function	NN
cord-322966-o65fo853	146	12	may	may	MD
cord-322966-o65fo853	146	13	be	be	VB
cord-322966-o65fo853	146	14	another	another	DT
cord-322966-o65fo853	146	15	factor	factor	NN
cord-322966-o65fo853	146	16	contributing	contribute	VBG
cord-322966-o65fo853	146	17	to	to	IN
cord-322966-o65fo853	146	18	greater	great	JJR
cord-322966-o65fo853	146	19	imbalance	imbalance	NN
cord-322966-o65fo853	146	20	of	of	IN
cord-322966-o65fo853	146	21	the	the	DT
cord-322966-o65fo853	146	22	ACE	ace	NN
cord-322966-o65fo853	146	23	:	:	:
cord-322966-o65fo853	146	24	ACE-2	ACE-2	NNP
cord-322966-o65fo853	146	25	system	system	NN
cord-322966-o65fo853	146	26	leading	lead	VBG
cord-322966-o65fo853	146	27	to	to	IN
cord-322966-o65fo853	146	28	differences	difference	NNS
cord-322966-o65fo853	146	29	in	in	IN
cord-322966-o65fo853	146	30	disease	disease	NN
cord-322966-o65fo853	146	31	severity	severity	NN
cord-322966-o65fo853	146	32	in	in	IN
cord-322966-o65fo853	146	33	COVID-	covid-	NN
cord-322966-o65fo853	146	34	19	19	CD
cord-322966-o65fo853	146	35	.	.	.
cord-322966-o65fo853	147	1	It	-PRON-	PRP
cord-322966-o65fo853	147	2	has	have	VBZ
cord-322966-o65fo853	147	3	been	be	VBN
cord-322966-o65fo853	147	4	suggested	suggest	VBN
cord-322966-o65fo853	147	5	that	that	IN
cord-322966-o65fo853	147	6	vitamin	vitamin	NN
cord-322966-o65fo853	147	7	D	D	NNP
cord-322966-o65fo853	147	8	supplementation	supplementation	NN
cord-322966-o65fo853	147	9	could	could	MD
cord-322966-o65fo853	147	10	reduce	reduce	VB
cord-322966-o65fo853	147	11	the	the	DT
cord-322966-o65fo853	147	12	risk	risk	NN
cord-322966-o65fo853	147	13	of	of	IN
cord-322966-o65fo853	147	14	COVID-19	covid-19	JJ
cord-322966-o65fo853	147	15	infection	infection	NN
cord-322966-o65fo853	147	16	and	and	CC
cord-322966-o65fo853	147	17	death	death	NN
cord-322966-o65fo853	147	18	[	[	-LRB-
cord-322966-o65fo853	147	19	53	53	CD
cord-322966-o65fo853	147	20	]	]	-RRB-
cord-322966-o65fo853	147	21	.	.	.
cord-322966-o65fo853	148	1	Lau	Lau	NNP
cord-322966-o65fo853	148	2	et	et	NNP
cord-322966-o65fo853	148	3	al	al	NNP
cord-322966-o65fo853	148	4	.	.	.
cord-322966-o65fo853	149	1	[	[	-LRB-
cord-322966-o65fo853	149	2	17	17	CD
cord-322966-o65fo853	149	3	]	]	-RRB-
cord-322966-o65fo853	149	4	reported	report	VBD
cord-322966-o65fo853	149	5	a	a	DT
cord-322966-o65fo853	149	6	small	small	JJ
cord-322966-o65fo853	149	7	study	study	NN
cord-322966-o65fo853	149	8	of	of	IN
cord-322966-o65fo853	149	9	vitamin	vitamin	NN
cord-322966-o65fo853	149	10	D	d	NN
cord-322966-o65fo853	149	11	levels	level	NNS
cord-322966-o65fo853	149	12	in	in	IN
cord-322966-o65fo853	149	13	20	20	CD
cord-322966-o65fo853	149	14	patients	patient	NNS
cord-322966-o65fo853	149	15	which	which	WDT
cord-322966-o65fo853	149	16	is	be	VBZ
cord-322966-o65fo853	149	17	yet	yet	RB
cord-322966-o65fo853	149	18	to	to	TO
cord-322966-o65fo853	149	19	be	be	VB
cord-322966-o65fo853	149	20	peer	peer	NN
cord-322966-o65fo853	149	21	reviewed	review	VBN
cord-322966-o65fo853	149	22	.	.	.
cord-322966-o65fo853	150	1	They	-PRON-	PRP
cord-322966-o65fo853	150	2	described	describe	VBD
cord-322966-o65fo853	150	3	vitamin	vitamin	NN
cord-322966-o65fo853	150	4	D	D	NNP
cord-322966-o65fo853	150	5	deficiency	deficiency	NN
cord-322966-o65fo853	150	6	in	in	IN
cord-322966-o65fo853	150	7	84.6	84.6	CD
cord-322966-o65fo853	150	8	%	%	NN
cord-322966-o65fo853	150	9	of	of	IN
cord-322966-o65fo853	150	10	COVID-19	covid-19	JJ
cord-322966-o65fo853	150	11	patients	patient	NNS
cord-322966-o65fo853	150	12	in	in	IN
cord-322966-o65fo853	150	13	ICU	ICU	NNP
cord-322966-o65fo853	150	14	and	and	CC
cord-322966-o65fo853	150	15	57.1	57.1	CD
cord-322966-o65fo853	150	16	%	%	NN
cord-322966-o65fo853	150	17	of	of	IN
cord-322966-o65fo853	150	18	patients	patient	NNS
cord-322966-o65fo853	150	19	admitted	admit	VBN
cord-322966-o65fo853	150	20	to	to	IN
cord-322966-o65fo853	150	21	a	a	DT
cord-322966-o65fo853	150	22	ward	ward	NN
cord-322966-o65fo853	150	23	bed	bed	NN
cord-322966-o65fo853	150	24	.	.	.
cord-322966-o65fo853	151	1	They	-PRON-	PRP
cord-322966-o65fo853	151	2	found	find	VBD
cord-322966-o65fo853	151	3	that	that	IN
cord-322966-o65fo853	151	4	100	100	CD
cord-322966-o65fo853	151	5	%	%	NN
cord-322966-o65fo853	151	6	of	of	IN
cord-322966-o65fo853	151	7	patients	patient	NNS
cord-322966-o65fo853	151	8	under	under	IN
cord-322966-o65fo853	151	9	age	age	NN
cord-322966-o65fo853	151	10	75	75	CD
cord-322966-o65fo853	151	11	admitted	admit	VBD
cord-322966-o65fo853	151	12	to	to	IN
cord-322966-o65fo853	151	13	ICU	ICU	NNP
cord-322966-o65fo853	151	14	had	have	VBD
cord-322966-o65fo853	151	15	vitamin	vitamin	NN
cord-322966-o65fo853	151	16	D	D	NNP
cord-322966-o65fo853	151	17	deficiency	deficiency	NN
cord-322966-o65fo853	151	18	(	(	-LRB-
cord-322966-o65fo853	151	19	n=11	n=11	NNP
cord-322966-o65fo853	151	20	)	)	-RRB-
cord-322966-o65fo853	151	21	.	.	.
cord-322966-o65fo853	152	1	ACE	ACE	NNP
cord-322966-o65fo853	152	2	is	be	VBZ
cord-322966-o65fo853	152	3	best	well	RBS
cord-322966-o65fo853	152	4	known	know	VBN
cord-322966-o65fo853	152	5	for	for	IN
cord-322966-o65fo853	152	6	its	-PRON-	PRP$
cord-322966-o65fo853	152	7	role	role	NN
cord-322966-o65fo853	152	8	in	in	IN
cord-322966-o65fo853	152	9	blood	blood	NN
cord-322966-o65fo853	152	10	pressure	pressure	NN
cord-322966-o65fo853	152	11	regulation	regulation	NN
cord-322966-o65fo853	152	12	by	by	IN
cord-322966-o65fo853	152	13	converting	convert	VBG
cord-322966-o65fo853	152	14	angiotensin	angiotensin	NN
cord-322966-o65fo853	152	15	I	-PRON-	PRP
cord-322966-o65fo853	152	16	to	to	IN
cord-322966-o65fo853	152	17	Ang	Ang	NNP
cord-322966-o65fo853	152	18	II	II	NNP
cord-322966-o65fo853	152	19	,	,	,
cord-322966-o65fo853	152	20	but	but	CC
cord-322966-o65fo853	152	21	in	in	IN
cord-322966-o65fo853	152	22	fact	fact	NN
cord-322966-o65fo853	152	23	it	-PRON-	PRP
cord-322966-o65fo853	152	24	cleaves	cleave	VBZ
cord-322966-o65fo853	152	25	many	many	JJ
cord-322966-o65fo853	152	26	peptides	peptide	NNS
cord-322966-o65fo853	152	27	and	and	CC
cord-322966-o65fo853	152	28	has	have	VBZ
cord-322966-o65fo853	152	29	a	a	DT
cord-322966-o65fo853	152	30	role	role	NN
cord-322966-o65fo853	152	31	in	in	IN
cord-322966-o65fo853	152	32	innate	innate	JJ
cord-322966-o65fo853	152	33	and	and	CC
cord-322966-o65fo853	152	34	adaptive	adaptive	JJ
cord-322966-o65fo853	152	35	immune	immune	JJ
cord-322966-o65fo853	152	36	responses	response	NNS
cord-322966-o65fo853	152	37	,	,	,
cord-322966-o65fo853	152	38	with	with	IN
cord-322966-o65fo853	152	39	ACE	ACE	NNP
cord-322966-o65fo853	152	40	expressed	express	VBD
cord-322966-o65fo853	152	41	on	on	IN
cord-322966-o65fo853	152	42	both	both	DT
cord-322966-o65fo853	152	43	neutrophils	neutrophil	NNS
cord-322966-o65fo853	152	44	and	and	CC
cord-322966-o65fo853	152	45	macrophages	macrophage	NNS
cord-322966-o65fo853	152	46	.	.	.
cord-322966-o65fo853	153	1	The	the	DT
cord-322966-o65fo853	153	2	role	role	NN
cord-322966-o65fo853	153	3	of	of	IN
cord-322966-o65fo853	153	4	ACE	ace	NN
cord-322966-o65fo853	153	5	in	in	IN
cord-322966-o65fo853	153	6	immune	immune	JJ
cord-322966-o65fo853	153	7	responses	response	NNS
cord-322966-o65fo853	153	8	and	and	CC
cord-322966-o65fo853	153	9	inflammation	inflammation	NN
cord-322966-o65fo853	153	10	is	be	VBZ
cord-322966-o65fo853	153	11	complex	complex	JJ
cord-322966-o65fo853	153	12	and	and	CC
cord-322966-o65fo853	153	13	includes	include	VBZ
cord-322966-o65fo853	153	14	defence	defence	NN
cord-322966-o65fo853	153	15	against	against	IN
cord-322966-o65fo853	153	16	intracellular	intracellular	JJ
cord-322966-o65fo853	153	17	pathogens	pathogen	NNS
cord-322966-o65fo853	153	18	,	,	,
cord-322966-o65fo853	153	19	mediated	mediate	VBN
cord-322966-o65fo853	153	20	via	via	IN
cord-322966-o65fo853	153	21	actions	action	NNS
cord-322966-o65fo853	153	22	that	that	WDT
cord-322966-o65fo853	153	23	are	be	VBP
cord-322966-o65fo853	153	24	not	not	RB
cord-322966-o65fo853	153	25	dependent	dependent	JJ
cord-322966-o65fo853	153	26	on	on	IN
cord-322966-o65fo853	153	27	Ang	Ang	NNP
cord-322966-o65fo853	153	28	II	II	NNP
cord-322966-o65fo853	153	29	,	,	,
cord-322966-o65fo853	153	30	as	as	IN
cord-322966-o65fo853	153	31	reviewed	review	VBN
cord-322966-o65fo853	153	32	by	by	IN
cord-322966-o65fo853	153	33	Bernstein	Bernstein	NNP
cord-322966-o65fo853	153	34	and	and	CC
cord-322966-o65fo853	153	35	co	co	NNS
cord-322966-o65fo853	153	36	-	-	NNS
cord-322966-o65fo853	153	37	workers	worker	NNS
cord-322966-o65fo853	153	38	[	[	-LRB-
cord-322966-o65fo853	153	39	18	18	CD
cord-322966-o65fo853	153	40	]	]	-RRB-
cord-322966-o65fo853	153	41	.	.	.
cord-322966-o65fo853	154	1	These	these	DT
cord-322966-o65fo853	154	2	complex	complex	JJ
cord-322966-o65fo853	154	3	interactions	interaction	NNS
cord-322966-o65fo853	154	4	mean	mean	VBP
cord-322966-o65fo853	154	5	that	that	IN
cord-322966-o65fo853	154	6	ACEI	ACEI	NNP
cord-322966-o65fo853	154	7	and	and	CC
cord-322966-o65fo853	154	8	ARBs	arb	NNS
cord-322966-o65fo853	154	9	may	may	MD
cord-322966-o65fo853	154	10	not	not	RB
cord-322966-o65fo853	154	11	have	have	VB
cord-322966-o65fo853	154	12	the	the	DT
cord-322966-o65fo853	154	13	same	same	JJ
cord-322966-o65fo853	154	14	impacts	impact	NNS
cord-322966-o65fo853	154	15	in	in	IN
cord-322966-o65fo853	154	16	COVID-19	COVID-19	NNP
cord-322966-o65fo853	154	17	,	,	,
cord-322966-o65fo853	154	18	a	a	DT
cord-322966-o65fo853	154	19	disease	disease	NN
cord-322966-o65fo853	154	20	impacting	impact	VBG
cord-322966-o65fo853	154	21	both	both	CC
cord-322966-o65fo853	154	22	haemodynamic	haemodynamic	JJ
cord-322966-o65fo853	154	23	and	and	CC
cord-322966-o65fo853	154	24	inflammatory	inflammatory	JJ
cord-322966-o65fo853	154	25	pathways	pathway	NNS
cord-322966-o65fo853	154	26	.	.	.
cord-322966-o65fo853	155	1	Many	many	JJ
cord-322966-o65fo853	155	2	agents	agent	NNS
cord-322966-o65fo853	155	3	are	be	VBP
cord-322966-o65fo853	155	4	under	under	IN
cord-322966-o65fo853	155	5	investigation	investigation	NN
cord-322966-o65fo853	155	6	or	or	CC
cord-322966-o65fo853	155	7	in	in	IN
cord-322966-o65fo853	155	8	clinical	clinical	JJ
cord-322966-o65fo853	155	9	trial	trial	NN
cord-322966-o65fo853	155	10	for	for	IN
cord-322966-o65fo853	155	11	the	the	DT
cord-322966-o65fo853	155	12	treatment	treatment	NN
cord-322966-o65fo853	155	13	of	of	IN
cord-322966-o65fo853	155	14	COVID-19	covid-19	NN
cord-322966-o65fo853	155	15	but	but	CC
cord-322966-o65fo853	155	16	so	so	RB
cord-322966-o65fo853	155	17	far	far	RB
cord-322966-o65fo853	155	18	no	no	DT
cord-322966-o65fo853	155	19	anti	anti	JJ
cord-322966-o65fo853	155	20	-	-	JJ
cord-322966-o65fo853	155	21	viral	viral	JJ
cord-322966-o65fo853	155	22	drugs	drug	NNS
cord-322966-o65fo853	155	23	or	or	CC
cord-322966-o65fo853	155	24	vaccine	vaccine	NN
cord-322966-o65fo853	155	25	has	have	VBZ
cord-322966-o65fo853	155	26	been	be	VBN
cord-322966-o65fo853	155	27	officially	officially	RB
cord-322966-o65fo853	155	28	approved	approve	VBN
cord-322966-o65fo853	155	29	for	for	IN
cord-322966-o65fo853	155	30	COVID-19	COVID-19	NNP
cord-322966-o65fo853	155	31	treatment	treatment	NN
cord-322966-o65fo853	155	32	.	.	.
cord-322966-o65fo853	156	1	Hundreds	hundred	NNS
cord-322966-o65fo853	156	2	of	of	IN
cord-322966-o65fo853	156	3	trials	trial	NNS
cord-322966-o65fo853	156	4	are	be	VBP
cord-322966-o65fo853	156	5	listed	list	VBN
cord-322966-o65fo853	156	6	in	in	IN
cord-322966-o65fo853	156	7	the	the	DT
cord-322966-o65fo853	156	8	WHO	WHO	NNP
cord-322966-o65fo853	157	1	COVID-19	COVID-19	NNP
cord-322966-o65fo853	157	2	Trial	Trial	NNP
cord-322966-o65fo853	157	3	data	data	NN
cord-322966-o65fo853	157	4	base	base	NN
cord-322966-o65fo853	157	5	(	(	-LRB-
cord-322966-o65fo853	157	6	www.who.int	www.who.int	NNP
cord-322966-o65fo853	157	7	International	International	NNP
cord-322966-o65fo853	157	8	Clinical	Clinical	NNP
cord-322966-o65fo853	157	9	Trials	Trials	NNPS
cord-322966-o65fo853	157	10	Registry	Registry	NNP
cord-322966-o65fo853	157	11	)	)	-RRB-
cord-322966-o65fo853	157	12	.	.	.
cord-322966-o65fo853	158	1	A	a	DT
cord-322966-o65fo853	158	2	small	small	JJ
cord-322966-o65fo853	158	3	trial	trial	NN
cord-322966-o65fo853	158	4	using	use	VBG
cord-322966-o65fo853	158	5	hydroxychloroquine	hydroxychloroquine	NNP
cord-322966-o65fo853	158	6	and	and	CC
cord-322966-o65fo853	158	7	azithromycin	azithromycin	NNP
cord-322966-o65fo853	158	8	showed	show	VBD
cord-322966-o65fo853	158	9	some	some	DT
cord-322966-o65fo853	158	10	promise	promise	NN
cord-322966-o65fo853	158	11	in	in	IN
cord-322966-o65fo853	158	12	decreasing	decrease	VBG
cord-322966-o65fo853	158	13	viral	viral	JJ
cord-322966-o65fo853	158	14	carriage	carriage	NN
cord-322966-o65fo853	158	15	to	to	IN
cord-322966-o65fo853	158	16	only	only	RB
cord-322966-o65fo853	158	17	3	3	CD
cord-322966-o65fo853	158	18	to	to	TO
cord-322966-o65fo853	158	19	6	6	CD
cord-322966-o65fo853	158	20	days	day	NNS
cord-322966-o65fo853	158	21	[	[	-LRB-
cord-322966-o65fo853	158	22	54	54	CD
cord-322966-o65fo853	158	23	]	]	-RRB-
cord-322966-o65fo853	158	24	,	,	,
cord-322966-o65fo853	158	25	an	an	DT
cord-322966-o65fo853	158	26	improvement	improvement	NN
cord-322966-o65fo853	158	27	on	on	IN
cord-322966-o65fo853	158	28	20	20	CD
cord-322966-o65fo853	158	29	days	day	NNS
cord-322966-o65fo853	158	30	reported	report	VBN
cord-322966-o65fo853	158	31	from	from	IN
cord-322966-o65fo853	158	32	China	China	NNP
cord-322966-o65fo853	158	33	[	[	-LRB-
cord-322966-o65fo853	158	34	1	1	CD
cord-322966-o65fo853	158	35	]	]	-RRB-
cord-322966-o65fo853	158	36	.	.	.
cord-322966-o65fo853	159	1	This	this	DT
cord-322966-o65fo853	159	2	combination	combination	NN
cord-322966-o65fo853	159	3	could	could	MD
cord-322966-o65fo853	159	4	,	,	,
cord-322966-o65fo853	159	5	however	however	RB
cord-322966-o65fo853	159	6	,	,	,
cord-322966-o65fo853	159	7	carry	carry	VBP
cord-322966-o65fo853	159	8	a	a	DT
cord-322966-o65fo853	159	9	risk	risk	NN
cord-322966-o65fo853	159	10	of	of	IN
cord-322966-o65fo853	159	11	arrhythmia	arrhythmia	NN
cord-322966-o65fo853	159	12	due	due	IN
cord-322966-o65fo853	159	13	to	to	IN
cord-322966-o65fo853	159	14	long	long	JJ
cord-322966-o65fo853	159	15	QT	qt	NN
cord-322966-o65fo853	159	16	,	,	,
cord-322966-o65fo853	159	17	in	in	IN
cord-322966-o65fo853	159	18	a	a	DT
cord-322966-o65fo853	159	19	group	group	NN
cord-322966-o65fo853	159	20	of	of	IN
cord-322966-o65fo853	159	21	patients	patient	NNS
cord-322966-o65fo853	159	22	where	where	WRB
cord-322966-o65fo853	159	23	abnormal	abnormal	JJ
cord-322966-o65fo853	159	24	troponins	troponin	NNS
cord-322966-o65fo853	159	25	and	and	CC
cord-322966-o65fo853	159	26	endothelial	endothelial	JJ
cord-322966-o65fo853	159	27	dysfunction	dysfunction	NN
cord-322966-o65fo853	159	28	can	can	MD
cord-322966-o65fo853	159	29	be	be	VB
cord-322966-o65fo853	159	30	present	present	JJ
cord-322966-o65fo853	159	31	,	,	,
cord-322966-o65fo853	159	32	with	with	IN
cord-322966-o65fo853	159	33	some	some	DT
cord-322966-o65fo853	159	34	arrythmias	arrythmia	NNS
cord-322966-o65fo853	159	35	reported	report	VBN
cord-322966-o65fo853	159	36	in	in	IN
cord-322966-o65fo853	159	37	China	China	NNP
cord-322966-o65fo853	159	38	[	[	-LRB-
cord-322966-o65fo853	159	39	1	1	CD
cord-322966-o65fo853	159	40	]	]	-RRB-
cord-322966-o65fo853	159	41	.	.	.
cord-322966-o65fo853	160	1	Longer	long	JJR
cord-322966-o65fo853	160	2	trials	trial	NNS
cord-322966-o65fo853	160	3	will	will	MD
cord-322966-o65fo853	160	4	be	be	VB
cord-322966-o65fo853	160	5	needed	need	VBN
cord-322966-o65fo853	160	6	.	.	.
cord-322966-o65fo853	161	1	Preliminary	preliminary	JJ
cord-322966-o65fo853	161	2	clinical	clinical	JJ
cord-322966-o65fo853	161	3	data	datum	NNS
cord-322966-o65fo853	161	4	for	for	IN
cord-322966-o65fo853	161	5	the	the	DT
cord-322966-o65fo853	161	6	investigational	investigational	JJ
cord-322966-o65fo853	161	7	RNA	RNA	NNP
cord-322966-o65fo853	161	8	antiviral	antiviral	JJ
cord-322966-o65fo853	161	9	agent	agent	NN
cord-322966-o65fo853	161	10	,	,	,
cord-322966-o65fo853	161	11	remdesivir	remdesivir	NNP
cord-322966-o65fo853	161	12	,	,	,
cord-322966-o65fo853	161	13	did	do	VBD
cord-322966-o65fo853	161	14	not	not	RB
cord-322966-o65fo853	161	15	show	show	VB
cord-322966-o65fo853	161	16	a	a	DT
cord-322966-o65fo853	161	17	survival	survival	NN
cord-322966-o65fo853	161	18	benefit	benefit	NN
cord-322966-o65fo853	161	19	in	in	IN
cord-322966-o65fo853	161	20	a	a	DT
cord-322966-o65fo853	161	21	study	study	NN
cord-322966-o65fo853	161	22	of	of	IN
cord-322966-o65fo853	161	23	237	237	CD
cord-322966-o65fo853	161	24	patients	patient	NNS
cord-322966-o65fo853	161	25	in	in	IN
cord-322966-o65fo853	161	26	China	China	NNP
cord-322966-o65fo853	161	27	but	but	CC
cord-322966-o65fo853	161	28	did	do	VBD
cord-322966-o65fo853	161	29	show	show	VB
cord-322966-o65fo853	161	30	a	a	DT
cord-322966-o65fo853	161	31	trend	trend	NN
cord-322966-o65fo853	161	32	to	to	IN
cord-322966-o65fo853	161	33	earlier	early	JJR
cord-322966-o65fo853	161	34	recovery	recovery	NN
cord-322966-o65fo853	161	35	[	[	-LRB-
cord-322966-o65fo853	161	36	55	55	CD
cord-322966-o65fo853	161	37	]	]	-RRB-
cord-322966-o65fo853	161	38	,	,	,
cord-322966-o65fo853	161	39	and	and	CC
cord-322966-o65fo853	161	40	the	the	DT
cord-322966-o65fo853	161	41	Adaptive	Adaptive	NNP
cord-322966-o65fo853	161	42	COVID-19	COVID-19	NNP
cord-322966-o65fo853	161	43	Treatment	Treatment	NNP
cord-322966-o65fo853	161	44	Trial	Trial	NNP
cord-322966-o65fo853	161	45	(	(	-LRB-
cord-322966-o65fo853	161	46	ACTT	ACTT	NNP
cord-322966-o65fo853	161	47	)	)	-RRB-
cord-322966-o65fo853	161	48	a	a	DT
cord-322966-o65fo853	161	49	study	study	NN
cord-322966-o65fo853	161	50	of	of	IN
cord-322966-o65fo853	161	51	1,063	1,063	CD
cord-322966-o65fo853	161	52	patients	patient	NNS
cord-322966-o65fo853	161	53	with	with	IN
cord-322966-o65fo853	161	54	lung	lung	NN
cord-322966-o65fo853	161	55	involvement	involvement	NN
cord-322966-o65fo853	161	56	in	in	IN
cord-322966-o65fo853	161	57	the	the	DT
cord-322966-o65fo853	161	58	USA	USA	NNP
cord-322966-o65fo853	161	59	has	have	VBZ
cord-322966-o65fo853	161	60	not	not	RB
cord-322966-o65fo853	161	61	yet	yet	RB
cord-322966-o65fo853	161	62	been	be	VBN
cord-322966-o65fo853	161	63	peer	peer	NN
cord-322966-o65fo853	161	64	reviewed	review	VBN
cord-322966-o65fo853	161	65	but	but	CC
cord-322966-o65fo853	161	66	a	a	DT
cord-322966-o65fo853	161	67	press	press	NN
cord-322966-o65fo853	161	68	release	release	NN
cord-322966-o65fo853	161	69	from	from	IN
cord-322966-o65fo853	161	70	the	the	DT
cord-322966-o65fo853	161	71	National	National	NNP
cord-322966-o65fo853	161	72	Institutes	Institutes	NNPS
cord-322966-o65fo853	161	73	of	of	IN
cord-322966-o65fo853	161	74	Health	Health	NNP
cord-322966-o65fo853	161	75	(	(	-LRB-
cord-322966-o65fo853	161	76	NIH	NIH	NNP
cord-322966-o65fo853	161	77	)	)	-RRB-
cord-322966-o65fo853	161	78	[	[	-LRB-
cord-322966-o65fo853	161	79	56	56	CD
cord-322966-o65fo853	161	80	]	]	-RRB-
cord-322966-o65fo853	161	81	reports	report	VBZ
cord-322966-o65fo853	161	82	a	a	DT
cord-322966-o65fo853	161	83	31	31	CD
cord-322966-o65fo853	161	84	%	%	NN
cord-322966-o65fo853	161	85	faster	fast	JJR
cord-322966-o65fo853	161	86	recovery	recovery	NN
cord-322966-o65fo853	161	87	time	time	NN
cord-322966-o65fo853	161	88	(	(	-LRB-
cord-322966-o65fo853	161	89	p<0.001	p<0.001	NNS
cord-322966-o65fo853	161	90	)	)	-RRB-
cord-322966-o65fo853	161	91	of	of	IN
cord-322966-o65fo853	161	92	11	11	CD
cord-322966-o65fo853	161	93	versus	versus	IN
cord-322966-o65fo853	161	94	15	15	CD
cord-322966-o65fo853	161	95	days	day	NNS
cord-322966-o65fo853	161	96	and	and	CC
cord-322966-o65fo853	161	97	possibly	possibly	RB
cord-322966-o65fo853	161	98	a	a	DT
cord-322966-o65fo853	161	99	trend	trend	NN
cord-322966-o65fo853	161	100	to	to	IN
cord-322966-o65fo853	161	101	a	a	DT
cord-322966-o65fo853	161	102	survival	survival	NN
cord-322966-o65fo853	161	103	benefit	benefit	NN
cord-322966-o65fo853	161	104	with	with	IN
cord-322966-o65fo853	161	105	8	8	CD
cord-322966-o65fo853	161	106	%	%	NN
cord-322966-o65fo853	161	107	versus	versus	IN
cord-322966-o65fo853	161	108	11.6	11.6	CD
cord-322966-o65fo853	161	109	%	%	NN
cord-322966-o65fo853	161	110	mortality	mortality	NN
cord-322966-o65fo853	161	111	(	(	-LRB-
cord-322966-o65fo853	161	112	p=0.059	p=0.059	NNP
cord-322966-o65fo853	161	113	)	)	-RRB-
cord-322966-o65fo853	161	114	.	.	.
cord-322966-o65fo853	162	1	A	a	DT
cord-322966-o65fo853	162	2	variety	variety	NN
cord-322966-o65fo853	162	3	of	of	IN
cord-322966-o65fo853	162	4	therapeutic	therapeutic	JJ
cord-322966-o65fo853	162	5	approaches	approach	NNS
cord-322966-o65fo853	162	6	,	,	,
cord-322966-o65fo853	162	7	in	in	IN
cord-322966-o65fo853	162	8	addition	addition	NN
cord-322966-o65fo853	162	9	to	to	IN
cord-322966-o65fo853	162	10	a	a	DT
cord-322966-o65fo853	162	11	vaccine	vaccine	NN
cord-322966-o65fo853	162	12	,	,	,
cord-322966-o65fo853	162	13	may	may	MD
cord-322966-o65fo853	162	14	contribute	contribute	VB
cord-322966-o65fo853	162	15	to	to	IN
cord-322966-o65fo853	162	16	COVID-19	covid-19	JJ
cord-322966-o65fo853	162	17	treatment	treatment	NN
cord-322966-o65fo853	162	18	and	and	CC
cord-322966-o65fo853	162	19	prevention	prevention	NN
cord-322966-o65fo853	162	20	in	in	IN
cord-322966-o65fo853	162	21	the	the	DT
cord-322966-o65fo853	162	22	medium	medium	JJ
cord-322966-o65fo853	162	23	and	and	CC
cord-322966-o65fo853	162	24	long	long	JJ
cord-322966-o65fo853	162	25	term	term	NN
cord-322966-o65fo853	162	26	.	.	.
cord-322966-o65fo853	163	1	However	however	RB
cord-322966-o65fo853	163	2	,	,	,
cord-322966-o65fo853	163	3	in	in	IN
cord-322966-o65fo853	163	4	the	the	DT
cord-322966-o65fo853	163	5	current	current	JJ
cord-322966-o65fo853	163	6	more	more	RBR
cord-322966-o65fo853	163	7	urgent	urgent	JJ
cord-322966-o65fo853	163	8	situation	situation	NN
cord-322966-o65fo853	163	9	there	there	EX
cord-322966-o65fo853	163	10	are	be	VBP
cord-322966-o65fo853	163	11	2,075,668	2,075,668	CD
cord-322966-o65fo853	163	12	active	active	JJ
cord-322966-o65fo853	163	13	cases	case	NNS
cord-322966-o65fo853	163	14	and	and	CC
cord-322966-o65fo853	163	15	51,332	51,332	CD
cord-322966-o65fo853	163	16	(	(	-LRB-
cord-322966-o65fo853	163	17	2	2	CD
cord-322966-o65fo853	163	18	%	%	NN
cord-322966-o65fo853	163	19	)	)	-RRB-
cord-322966-o65fo853	163	20	are	be	VBP
cord-322966-o65fo853	163	21	serious	serious	JJ
cord-322966-o65fo853	163	22	or	or	CC
cord-322966-o65fo853	163	23	critical	critical	JJ
cord-322966-o65fo853	163	24	,	,	,
cord-322966-o65fo853	163	25	with	with	IN
cord-322966-o65fo853	163	26	many	many	JJ
cord-322966-o65fo853	163	27	countries	country	NNS
cord-322966-o65fo853	163	28	still	still	RB
cord-322966-o65fo853	163	29	in	in	IN
cord-322966-o65fo853	163	30	the	the	DT
cord-322966-o65fo853	163	31	exponential	exponential	JJ
cord-322966-o65fo853	163	32	rise	rise	NN
cord-322966-o65fo853	163	33	phase	phase	NN
cord-322966-o65fo853	163	34	of	of	IN
cord-322966-o65fo853	163	35	new	new	JJ
cord-322966-o65fo853	163	36	cases	case	NNS
cord-322966-o65fo853	163	37	.	.	.
cord-322966-o65fo853	164	1	Treatment	treatment	NN
cord-322966-o65fo853	164	2	that	that	WDT
cord-322966-o65fo853	164	3	can	can	MD
cord-322966-o65fo853	164	4	be	be	VB
cord-322966-o65fo853	164	5	distributed	distribute	VBN
cord-322966-o65fo853	164	6	in	in	IN
cord-322966-o65fo853	164	7	large	large	JJ
cord-322966-o65fo853	164	8	quantities	quantity	NNS
cord-322966-o65fo853	164	9	is	be	VBZ
cord-322966-o65fo853	164	10	needed	need	VBN
cord-322966-o65fo853	164	11	if	if	IN
cord-322966-o65fo853	164	12	the	the	DT
cord-322966-o65fo853	164	13	economic	economic	JJ
cord-322966-o65fo853	164	14	impact	impact	NN
cord-322966-o65fo853	164	15	of	of	IN
cord-322966-o65fo853	164	16	this	this	DT
cord-322966-o65fo853	164	17	pandemic	pandemic	NN
cord-322966-o65fo853	164	18	is	be	VBZ
cord-322966-o65fo853	164	19	to	to	TO
cord-322966-o65fo853	164	20	be	be	VB
cord-322966-o65fo853	164	21	addressed	address	VBN
cord-322966-o65fo853	164	22	.	.	.
cord-322966-o65fo853	165	1	A	a	DT
cord-322966-o65fo853	165	2	meta	meta	JJ
cord-322966-o65fo853	165	3	-	-	HYPH
cord-322966-o65fo853	165	4	analysis	analysis	NN
cord-322966-o65fo853	165	5	of	of	IN
cord-322966-o65fo853	165	6	cardiac	cardiac	JJ
cord-322966-o65fo853	165	7	troponin	troponin	JJ
cord-322966-o65fo853	165	8	results	result	NNS
cord-322966-o65fo853	165	9	in	in	IN
cord-322966-o65fo853	165	10	COVID	COVID	NNP
cord-322966-o65fo853	165	11	patients	patient	NNS
cord-322966-o65fo853	165	12	reported	report	VBD
cord-322966-o65fo853	165	13	that	that	IN
cord-322966-o65fo853	165	14	higher	high	JJR
cord-322966-o65fo853	165	15	levels	level	NNS
cord-322966-o65fo853	165	16	correlated	correlate	VBN
cord-322966-o65fo853	165	17	with	with	IN
cord-322966-o65fo853	165	18	more	more	RBR
cord-322966-o65fo853	165	19	severe	severe	JJ
cord-322966-o65fo853	165	20	disease	disease	NN
cord-322966-o65fo853	165	21	[	[	-LRB-
cord-322966-o65fo853	165	22	20	20	CD
cord-322966-o65fo853	165	23	]	]	-RRB-
cord-322966-o65fo853	165	24	.	.	.
cord-322966-o65fo853	166	1	This	this	DT
cord-322966-o65fo853	166	2	is	be	VBZ
cord-322966-o65fo853	166	3	consistent	consistent	JJ
cord-322966-o65fo853	166	4	with	with	IN
cord-322966-o65fo853	166	5	either	either	CC
cord-322966-o65fo853	166	6	myocarditis	myocarditis	NN
cord-322966-o65fo853	166	7	or	or	CC
cord-322966-o65fo853	166	8	an	an	DT
cord-322966-o65fo853	166	9	acute	acute	JJ
cord-322966-o65fo853	166	10	coronary	coronary	JJ
cord-322966-o65fo853	166	11	syndrome	syndrome	NN
cord-322966-o65fo853	166	12	,	,	,
cord-322966-o65fo853	166	13	conditions	condition	NNS
cord-322966-o65fo853	166	14	for	for	IN
cord-322966-o65fo853	166	15	which	which	WDT
cord-322966-o65fo853	166	16	manipulation	manipulation	NN
cord-322966-o65fo853	166	17	of	of	IN
cord-322966-o65fo853	166	18	the	the	DT
cord-322966-o65fo853	166	19	RAS	RAS	NNP
cord-322966-o65fo853	166	20	with	with	IN
cord-322966-o65fo853	166	21	commonly	commonly	RB
cord-322966-o65fo853	166	22	available	available	JJ
cord-322966-o65fo853	166	23	drugs	drug	NNS
cord-322966-o65fo853	166	24	,	,	,
cord-322966-o65fo853	166	25	already	already	RB
cord-322966-o65fo853	166	26	have	have	VBP
cord-322966-o65fo853	166	27	an	an	DT
cord-322966-o65fo853	166	28	indication	indication	NN
cord-322966-o65fo853	166	29	,	,	,
cord-322966-o65fo853	166	30	based	base	VBN
cord-322966-o65fo853	166	31	on	on	IN
cord-322966-o65fo853	166	32	treating	treat	VBG
cord-322966-o65fo853	166	33	endothelial	endothelial	JJ
cord-322966-o65fo853	166	34	and	and	CC
cord-322966-o65fo853	166	35	myocardial	myocardial	JJ
cord-322966-o65fo853	166	36	inflammation	inflammation	NN
cord-322966-o65fo853	166	37	.	.	.
cord-322966-o65fo853	167	1	Use	use	NN
cord-322966-o65fo853	167	2	of	of	IN
cord-322966-o65fo853	167	3	these	these	DT
cord-322966-o65fo853	167	4	drugs	drug	NNS
cord-322966-o65fo853	167	5	in	in	IN
cord-322966-o65fo853	167	6	COVID-19	covid-19	JJ
cord-322966-o65fo853	167	7	patients	patient	NNS
cord-322966-o65fo853	167	8	meeting	meet	VBG
cord-322966-o65fo853	167	9	the	the	DT
cord-322966-o65fo853	167	10	definition	definition	NN
cord-322966-o65fo853	167	11	for	for	IN
cord-322966-o65fo853	167	12	an	an	DT
cord-322966-o65fo853	167	13	acute	acute	JJ
cord-322966-o65fo853	167	14	coronary	coronary	JJ
cord-322966-o65fo853	167	15	syndrome	syndrome	NN
cord-322966-o65fo853	167	16	or	or	CC
cord-322966-o65fo853	167	17	for	for	IN
cord-322966-o65fo853	167	18	another	another	DT
cord-322966-o65fo853	167	19	valid	valid	JJ
cord-322966-o65fo853	167	20	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	167	21	indication	indication	NN
cord-322966-o65fo853	167	22	can	can	MD
cord-322966-o65fo853	167	23	now	now	RB
cord-322966-o65fo853	167	24	be	be	VB
cord-322966-o65fo853	167	25	given	give	VBN
cord-322966-o65fo853	167	26	with	with	IN
cord-322966-o65fo853	167	27	more	more	JJR
cord-322966-o65fo853	167	28	confidence	confidence	NN
cord-322966-o65fo853	167	29	in	in	IN
cord-322966-o65fo853	167	30	light	light	NN
cord-322966-o65fo853	167	31	of	of	IN
cord-322966-o65fo853	167	32	recent	recent	JJ
cord-322966-o65fo853	167	33	studies	study	NNS
cord-322966-o65fo853	167	34	showing	show	VBG
cord-322966-o65fo853	167	35	no	no	DT
cord-322966-o65fo853	167	36	detriment	detriment	NN
cord-322966-o65fo853	167	37	for	for	IN
cord-322966-o65fo853	167	38	these	these	DT
cord-322966-o65fo853	167	39	drugs	drug	NNS
cord-322966-o65fo853	167	40	in	in	IN
cord-322966-o65fo853	167	41	COVID-19	COVID-19	NNP
cord-322966-o65fo853	167	42	[	[	-LRB-
cord-322966-o65fo853	167	43	10	10	CD
cord-322966-o65fo853	167	44	,	,	,
cord-322966-o65fo853	167	45	14	14	CD
cord-322966-o65fo853	167	46	,	,	,
cord-322966-o65fo853	167	47	22	22	CD
cord-322966-o65fo853	167	48	]	]	-RRB-
cord-322966-o65fo853	167	49	.This	.This	.
cord-322966-o65fo853	168	1	approach	approach	NN
cord-322966-o65fo853	168	2	may	may	MD
cord-322966-o65fo853	168	3	be	be	VB
cord-322966-o65fo853	168	4	one	one	NN
cord-322966-o65fo853	168	5	that	that	WDT
cord-322966-o65fo853	168	6	is	be	VBZ
cord-322966-o65fo853	168	7	directed	direct	VBN
cord-322966-o65fo853	168	8	at	at	IN
cord-322966-o65fo853	168	9	fundamental	fundamental	JJ
cord-322966-o65fo853	168	10	viral	viral	JJ
cord-322966-o65fo853	168	11	vascular	vascular	JJ
cord-322966-o65fo853	168	12	pathogenesis	pathogenesis	NN
cord-322966-o65fo853	168	13	.	.	.
cord-322966-o65fo853	169	1	A	a	DT
cord-322966-o65fo853	169	2	broader	broad	JJR
cord-322966-o65fo853	169	3	therapeutic	therapeutic	JJ
cord-322966-o65fo853	169	4	role	role	NN
cord-322966-o65fo853	169	5	for	for	IN
cord-322966-o65fo853	169	6	RAS	RAS	NNP
cord-322966-o65fo853	169	7	inhibition	inhibition	NN
cord-322966-o65fo853	169	8	in	in	IN
cord-322966-o65fo853	169	9	COVID-19	COVID-19	NNP
cord-322966-o65fo853	169	10	is	be	VBZ
cord-322966-o65fo853	169	11	being	be	VBG
cord-322966-o65fo853	169	12	investigated	investigate	VBN
cord-322966-o65fo853	169	13	in	in	IN
cord-322966-o65fo853	169	14	two	two	CD
cord-322966-o65fo853	169	15	randomised	randomised	JJ
cord-322966-o65fo853	169	16	trials	trial	NNS
cord-322966-o65fo853	169	17	examining	examine	VBG
cord-322966-o65fo853	169	18	the	the	DT
cord-322966-o65fo853	169	19	effects	effect	NNS
cord-322966-o65fo853	169	20	of	of	IN
cord-322966-o65fo853	169	21	the	the	DT
cord-322966-o65fo853	169	22	ARB	ARB	NNP
cord-322966-o65fo853	169	23	losartan	losartan	NN
cord-322966-o65fo853	169	24	on	on	IN
cord-322966-o65fo853	169	25	the	the	DT
cord-322966-o65fo853	169	26	severity	severity	NN
cord-322966-o65fo853	169	27	and	and	CC
cord-322966-o65fo853	169	28	prognosis	prognosis	NN
cord-322966-o65fo853	169	29	in	in	IN
cord-322966-o65fo853	169	30	COVID-19	COVID-19	NNP
cord-322966-o65fo853	169	31	,	,	,
cord-322966-o65fo853	169	32	in	in	IN
cord-322966-o65fo853	169	33	hospitalised	hospitalise	VBN
cord-322966-o65fo853	169	34	COVID-19	COVID-19	NNP
cord-322966-o65fo853	169	35	patients	patient	NNS
cord-322966-o65fo853	169	36	(	(	-LRB-
cord-322966-o65fo853	169	37	NCT	NCT	NNP
cord-322966-o65fo853	169	38	04312009	04312009	CD
cord-322966-o65fo853	169	39	)	)	-RRB-
cord-322966-o65fo853	169	40	and	and	CC
cord-322966-o65fo853	169	41	in	in	IN
cord-322966-o65fo853	169	42	non	non	JJ
cord-322966-o65fo853	169	43	-	-	JJ
cord-322966-o65fo853	169	44	hospitalised	hospitalise	VBN
cord-322966-o65fo853	169	45	patients	patient	NNS
cord-322966-o65fo853	169	46	(	(	-LRB-
cord-322966-o65fo853	169	47	NCT04311177	NCT04311177	NNP
cord-322966-o65fo853	169	48	)	)	-RRB-
cord-322966-o65fo853	169	49	.	.	.
cord-322966-o65fo853	170	1	In	in	IN
cord-322966-o65fo853	170	2	the	the	DT
cord-322966-o65fo853	170	3	current	current	JJ
cord-322966-o65fo853	170	4	global	global	JJ
cord-322966-o65fo853	170	5	COVID-19	COVID-19	NNP
cord-322966-o65fo853	170	6	pandemic	pandemic	NN
cord-322966-o65fo853	170	7	,	,	,
cord-322966-o65fo853	170	8	many	many	JJ
cord-322966-o65fo853	170	9	countries	country	NNS
cord-322966-o65fo853	170	10	are	be	VBP
cord-322966-o65fo853	170	11	in	in	IN
cord-322966-o65fo853	170	12	lockdown	lockdown	NN
cord-322966-o65fo853	170	13	with	with	IN
cord-322966-o65fo853	170	14	social	social	JJ
cord-322966-o65fo853	170	15	and	and	CC
cord-322966-o65fo853	170	16	economic	economic	JJ
cord-322966-o65fo853	170	17	paralysis	paralysis	NN
cord-322966-o65fo853	170	18	.	.	.
cord-322966-o65fo853	171	1	The	the	DT
cord-322966-o65fo853	171	2	impact	impact	NN
cord-322966-o65fo853	171	3	of	of	IN
cord-322966-o65fo853	171	4	COVID-19	COVID-19	NNP
cord-322966-o65fo853	171	5	has	have	VBZ
cord-322966-o65fo853	171	6	been	be	VBN
cord-322966-o65fo853	171	7	described	describe	VBN
cord-322966-o65fo853	171	8	as	as	IN
cord-322966-o65fo853	171	9	a	a	DT
cord-322966-o65fo853	171	10	warzone	warzone	NN
cord-322966-o65fo853	171	11	with	with	IN
cord-322966-o65fo853	171	12	many	many	JJ
cord-322966-o65fo853	171	13	patients	patient	NNS
cord-322966-o65fo853	171	14	dying	die	VBG
cord-322966-o65fo853	171	15	a	a	DT
cord-322966-o65fo853	171	16	lonely	lonely	JJ
cord-322966-o65fo853	171	17	death	death	NN
cord-322966-o65fo853	171	18	,	,	,
cord-322966-o65fo853	171	19	isolated	isolate	VBN
cord-322966-o65fo853	171	20	from	from	IN
cord-322966-o65fo853	171	21	loved	loved	JJ
cord-322966-o65fo853	171	22	ones	one	NNS
cord-322966-o65fo853	171	23	in	in	IN
cord-322966-o65fo853	171	24	overcrowded	overcrowded	JJ
cord-322966-o65fo853	171	25	and	and	CC
cord-322966-o65fo853	171	26	hastily	hastily	RB
cord-322966-o65fo853	171	27	expanded	expand	VBN
cord-322966-o65fo853	171	28	hospitals	hospital	NNS
cord-322966-o65fo853	171	29	.	.	.
cord-322966-o65fo853	172	1	Currently	currently	RB
cord-322966-o65fo853	172	2	,	,	,
cord-322966-o65fo853	172	3	only	only	RB
cord-322966-o65fo853	172	4	supportive	supportive	JJ
cord-322966-o65fo853	172	5	care	care	NN
cord-322966-o65fo853	172	6	is	be	VBZ
cord-322966-o65fo853	172	7	available	available	JJ
cord-322966-o65fo853	172	8	.	.	.
cord-322966-o65fo853	173	1	Whilst	whilst	IN
cord-322966-o65fo853	173	2	many	many	JJ
cord-322966-o65fo853	173	3	therapeutic	therapeutic	JJ
cord-322966-o65fo853	173	4	agents	agent	NNS
cord-322966-o65fo853	173	5	are	be	VBP
cord-322966-o65fo853	173	6	under	under	IN
cord-322966-o65fo853	173	7	investigation	investigation	NN
cord-322966-o65fo853	173	8	[	[	-LRB-
cord-322966-o65fo853	173	9	57	57	CD
cord-322966-o65fo853	173	10	,	,	,
cord-322966-o65fo853	173	11	58	58	CD
cord-322966-o65fo853	173	12	]	]	-RRB-
cord-322966-o65fo853	173	13	,	,	,
cord-322966-o65fo853	173	14	none	none	NN
cord-322966-o65fo853	173	15	have	have	VBP
cord-322966-o65fo853	173	16	yet	yet	RB
cord-322966-o65fo853	173	17	been	be	VBN
cord-322966-o65fo853	173	18	approved	approve	VBN
cord-322966-o65fo853	173	19	for	for	IN
cord-322966-o65fo853	173	20	use	use	NN
cord-322966-o65fo853	173	21	in	in	IN
cord-322966-o65fo853	173	22	COVID-19	COVID-19	NNP
cord-322966-o65fo853	173	23	,	,	,
cord-322966-o65fo853	173	24	nor	nor	CC
cord-322966-o65fo853	173	25	demonstrated	demonstrate	VBD
cord-322966-o65fo853	173	26	a	a	DT
cord-322966-o65fo853	173	27	significant	significant	JJ
cord-322966-o65fo853	173	28	survival	survival	NN
cord-322966-o65fo853	173	29	benefit	benefit	NN
cord-322966-o65fo853	173	30	.	.	.
cord-322966-o65fo853	174	1	Even	even	RB
cord-322966-o65fo853	174	2	if	if	IN
cord-322966-o65fo853	174	3	some	some	DT
cord-322966-o65fo853	174	4	agents	agent	NNS
cord-322966-o65fo853	174	5	are	be	VBP
cord-322966-o65fo853	174	6	proven	prove	VBN
cord-322966-o65fo853	174	7	to	to	TO
cord-322966-o65fo853	174	8	be	be	VB
cord-322966-o65fo853	174	9	effective	effective	JJ
cord-322966-o65fo853	174	10	,	,	,
cord-322966-o65fo853	174	11	it	-PRON-	PRP
cord-322966-o65fo853	174	12	will	will	MD
cord-322966-o65fo853	174	13	take	take	VB
cord-322966-o65fo853	174	14	time	time	NN
cord-322966-o65fo853	174	15	for	for	IN
cord-322966-o65fo853	174	16	trials	trial	NNS
cord-322966-o65fo853	174	17	and	and	CC
cord-322966-o65fo853	174	18	for	for	IN
cord-322966-o65fo853	174	19	production	production	NN
cord-322966-o65fo853	174	20	on	on	IN
cord-322966-o65fo853	174	21	a	a	DT
cord-322966-o65fo853	174	22	large	large	JJ
cord-322966-o65fo853	174	23	scale	scale	NN
cord-322966-o65fo853	174	24	.	.	.
cord-322966-o65fo853	175	1	Thinking	think	VBG
cord-322966-o65fo853	175	2	of	of	IN
cord-322966-o65fo853	175	3	COVID-19	COVID-19	NNP
cord-322966-o65fo853	175	4	as	as	IN
cord-322966-o65fo853	175	5	a	a	DT
cord-322966-o65fo853	175	6	fundamentally	fundamentally	RB
cord-322966-o65fo853	175	7	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	175	8	disease	disease	NN
cord-322966-o65fo853	175	9	that	that	WDT
cord-322966-o65fo853	175	10	attacks	attack	VBZ
cord-322966-o65fo853	175	11	the	the	DT
cord-322966-o65fo853	175	12	endothelium	endothelium	NN
cord-322966-o65fo853	175	13	could	could	MD
cord-322966-o65fo853	175	14	provide	provide	VB
cord-322966-o65fo853	175	15	momentum	momentum	NN
cord-322966-o65fo853	175	16	to	to	TO
cord-322966-o65fo853	175	17	use	use	VB
cord-322966-o65fo853	175	18	safe	safe	JJ
cord-322966-o65fo853	175	19	,	,	,
cord-322966-o65fo853	175	20	established	establish	VBN
cord-322966-o65fo853	175	21	and	and	CC
cord-322966-o65fo853	175	22	widely	widely	RB
cord-322966-o65fo853	175	23	available	available	JJ
cord-322966-o65fo853	175	24	medications	medication	NNS
cord-322966-o65fo853	175	25	acting	act	VBG
cord-322966-o65fo853	175	26	on	on	IN
cord-322966-o65fo853	175	27	the	the	DT
cord-322966-o65fo853	175	28	RAS	RAS	NNP
cord-322966-o65fo853	175	29	,	,	,
cord-322966-o65fo853	175	30	where	where	WRB
cord-322966-o65fo853	175	31	they	-PRON-	PRP
cord-322966-o65fo853	175	32	are	be	VBP
cord-322966-o65fo853	175	33	already	already	RB
cord-322966-o65fo853	175	34	indicated	indicate	VBN
cord-322966-o65fo853	175	35	for	for	IN
cord-322966-o65fo853	175	36	acute	acute	JJ
cord-322966-o65fo853	175	37	coronary	coronary	JJ
cord-322966-o65fo853	175	38	syndrome	syndrome	NN
cord-322966-o65fo853	175	39	and	and	CC
cord-322966-o65fo853	175	40	cardiac	cardiac	JJ
cord-322966-o65fo853	175	41	dysfunction	dysfunction	NN
cord-322966-o65fo853	175	42	,	,	,
cord-322966-o65fo853	175	43	present	present	JJ
cord-322966-o65fo853	175	44	in	in	IN
cord-322966-o65fo853	175	45	many	many	JJ
cord-322966-o65fo853	175	46	patients	patient	NNS
cord-322966-o65fo853	175	47	with	with	IN
cord-322966-o65fo853	175	48	COVID-19	COVID-19	NNP
cord-322966-o65fo853	175	49	.	.	.
cord-322966-o65fo853	176	1	Whilst	whilst	IN
cord-322966-o65fo853	176	2	more	more	JJR
cord-322966-o65fo853	176	3	data	datum	NNS
cord-322966-o65fo853	176	4	on	on	IN
cord-322966-o65fo853	176	5	the	the	DT
cord-322966-o65fo853	176	6	role	role	NN
cord-322966-o65fo853	176	7	of	of	IN
cord-322966-o65fo853	176	8	vitamin	vitamin	NN
cord-322966-o65fo853	176	9	D	d	NN
cord-322966-o65fo853	176	10	in	in	IN
cord-322966-o65fo853	176	11	COVID	covid	JJ
cord-322966-o65fo853	176	12	pathogenesis	pathogenesis	NN
cord-322966-o65fo853	176	13	is	be	VBZ
cord-322966-o65fo853	176	14	needed	need	VBN
cord-322966-o65fo853	176	15	,	,	,
cord-322966-o65fo853	176	16	replacing	replace	VBG
cord-322966-o65fo853	176	17	an	an	DT
cord-322966-o65fo853	176	18	essential	essential	JJ
cord-322966-o65fo853	176	19	vitamin	vitamin	NN
cord-322966-o65fo853	176	20	when	when	WRB
cord-322966-o65fo853	176	21	it	-PRON-	PRP
cord-322966-o65fo853	176	22	is	be	VBZ
cord-322966-o65fo853	176	23	deficient	deficient	JJ
cord-322966-o65fo853	176	24	,	,	,
cord-322966-o65fo853	176	25	seems	seem	VBZ
cord-322966-o65fo853	176	26	a	a	DT
cord-322966-o65fo853	176	27	safe	safe	JJ
cord-322966-o65fo853	176	28	,	,	,
cord-322966-o65fo853	176	29	cost	cost	VBD
cord-322966-o65fo853	176	30	effective	effective	JJ
cord-322966-o65fo853	176	31	and	and	CC
cord-322966-o65fo853	176	32	easily	easily	RB
cord-322966-o65fo853	176	33	achieved	achieve	VBN
cord-322966-o65fo853	176	34	therapeutic	therapeutic	JJ
cord-322966-o65fo853	176	35	strategy	strategy	NN
cord-322966-o65fo853	176	36	.	.	.
cord-322966-o65fo853	177	1	Any	any	DT
cord-322966-o65fo853	177	2	successful	successful	JJ
cord-322966-o65fo853	177	3	shift	shift	NN
cord-322966-o65fo853	177	4	to	to	IN
cord-322966-o65fo853	177	5	milder	mild	JJR
cord-322966-o65fo853	177	6	disease	disease	NN
cord-322966-o65fo853	177	7	severity	severity	NN
cord-322966-o65fo853	177	8	will	will	MD
cord-322966-o65fo853	177	9	ease	ease	VB
cord-322966-o65fo853	177	10	the	the	DT
cord-322966-o65fo853	177	11	burden	burden	NN
cord-322966-o65fo853	177	12	on	on	IN
cord-322966-o65fo853	177	13	health	health	NN
cord-322966-o65fo853	177	14	care	care	NN
cord-322966-o65fo853	177	15	systems	system	NNS
cord-322966-o65fo853	177	16	.	.	.
cord-322966-o65fo853	178	1	Switching	switch	VBG
cord-322966-o65fo853	178	2	on	on	IN
cord-322966-o65fo853	178	3	endogenous	endogenous	JJ
cord-322966-o65fo853	178	4	anti	anti	JJ
cord-322966-o65fo853	178	5	-	-	JJ
cord-322966-o65fo853	178	6	inflammatory	inflammatory	JJ
cord-322966-o65fo853	178	7	pathways	pathway	NNS
cord-322966-o65fo853	178	8	may	may	MD
cord-322966-o65fo853	178	9	also	also	RB
cord-322966-o65fo853	178	10	play	play	VB
cord-322966-o65fo853	178	11	a	a	DT
cord-322966-o65fo853	178	12	key	key	JJ
cord-322966-o65fo853	178	13	role	role	NN
cord-322966-o65fo853	178	14	in	in	IN
cord-322966-o65fo853	178	15	decreasing	decrease	VBG
cord-322966-o65fo853	178	16	the	the	DT
cord-322966-o65fo853	178	17	risk	risk	NN
cord-322966-o65fo853	178	18	of	of	IN
cord-322966-o65fo853	178	19	longterm	longterm	JJ
cord-322966-o65fo853	178	20	vascular	vascular	JJ
cord-322966-o65fo853	178	21	and	and	CC
cord-322966-o65fo853	178	22	autoimmune	autoimmune	JJ
cord-322966-o65fo853	178	23	sequelae	sequela	NNS
cord-322966-o65fo853	178	24	in	in	IN
cord-322966-o65fo853	178	25	COVID-19	COVID-19	NNP
cord-322966-o65fo853	178	26	survivors	survivor	NNS
cord-322966-o65fo853	178	27	,	,	,
cord-322966-o65fo853	178	28	which	which	WDT
cord-322966-o65fo853	178	29	could	could	MD
cord-322966-o65fo853	178	30	pose	pose	VB
cord-322966-o65fo853	178	31	a	a	DT
cord-322966-o65fo853	178	32	further	further	JJ
cord-322966-o65fo853	178	33	economic	economic	JJ
cord-322966-o65fo853	178	34	burden	burden	NN
cord-322966-o65fo853	178	35	once	once	IN
cord-322966-o65fo853	178	36	the	the	DT
cord-322966-o65fo853	178	37	pandemic	pandemic	NN
cord-322966-o65fo853	178	38	is	be	VBZ
cord-322966-o65fo853	178	39	over	over	RB
cord-322966-o65fo853	178	40	.	.	.
cord-322966-o65fo853	179	1	Although	although	IN
cord-322966-o65fo853	179	2	there	there	EX
cord-322966-o65fo853	179	3	may	may	MD
cord-322966-o65fo853	179	4	be	be	VB
cord-322966-o65fo853	179	5	more	more	JJR
cord-322966-o65fo853	179	6	questions	question	NNS
cord-322966-o65fo853	179	7	than	than	IN
cord-322966-o65fo853	179	8	answers	answer	NNS
cord-322966-o65fo853	179	9	and	and	CC
cord-322966-o65fo853	179	10	hot	hot	JJ
cord-322966-o65fo853	179	11	debate	debate	NN
cord-322966-o65fo853	179	12	in	in	IN
cord-322966-o65fo853	179	13	the	the	DT
cord-322966-o65fo853	179	14	medical	medical	JJ
cord-322966-o65fo853	179	15	literature	literature	NN
cord-322966-o65fo853	179	16	about	about	IN
cord-322966-o65fo853	179	17	the	the	DT
cord-322966-o65fo853	179	18	role	role	NN
cord-322966-o65fo853	179	19	of	of	IN
cord-322966-o65fo853	179	20	the	the	DT
cord-322966-o65fo853	179	21	RAS	RAS	NNP
cord-322966-o65fo853	179	22	and	and	CC
cord-322966-o65fo853	179	23	drugs	drug	NNS
cord-322966-o65fo853	179	24	acting	act	VBG
cord-322966-o65fo853	179	25	on	on	IN
cord-322966-o65fo853	179	26	this	this	DT
cord-322966-o65fo853	179	27	system	system	NN
cord-322966-o65fo853	179	28	in	in	IN
cord-322966-o65fo853	179	29	COVID-19	COVID-19	NNP
cord-322966-o65fo853	179	30	,	,	,
cord-322966-o65fo853	179	31	the	the	DT
cord-322966-o65fo853	179	32	consensus	consensus	NN
cord-322966-o65fo853	179	33	opinion	opinion	NN
cord-322966-o65fo853	179	34	is	be	VBZ
cord-322966-o65fo853	179	35	they	-PRON-	PRP
cord-322966-o65fo853	179	36	are	be	VBP
cord-322966-o65fo853	179	37	safe	safe	JJ
cord-322966-o65fo853	179	38	to	to	TO
cord-322966-o65fo853	179	39	use	use	VB
cord-322966-o65fo853	179	40	in	in	IN
cord-322966-o65fo853	179	41	COVID-19	COVID-19	NNP
cord-322966-o65fo853	179	42	[	[	-LRB-
cord-322966-o65fo853	179	43	11	11	CD
cord-322966-o65fo853	179	44	,	,	,
cord-322966-o65fo853	179	45	12	12	CD
cord-322966-o65fo853	179	46	]	]	-RRB-
cord-322966-o65fo853	179	47	,	,	,
cord-322966-o65fo853	179	48	a	a	DT
cord-322966-o65fo853	179	49	view	view	NN
cord-322966-o65fo853	179	50	now	now	RB
cord-322966-o65fo853	179	51	supported	support	VBN
cord-322966-o65fo853	179	52	by	by	IN
cord-322966-o65fo853	179	53	retrospective	retrospective	JJ
cord-322966-o65fo853	179	54	clinical	clinical	JJ
cord-322966-o65fo853	179	55	data	datum	NNS
cord-322966-o65fo853	179	56	[	[	-LRB-
cord-322966-o65fo853	179	57	110	110	CD
cord-322966-o65fo853	179	58	,	,	,
cord-322966-o65fo853	179	59	14	14	CD
cord-322966-o65fo853	179	60	,	,	,
cord-322966-o65fo853	179	61	22	22	CD
cord-322966-o65fo853	179	62	,	,	,
cord-322966-o65fo853	179	63	[	[	-LRB-
cord-322966-o65fo853	179	64	28	28	CD
cord-322966-o65fo853	179	65	]	]	-RRB-
cord-322966-o65fo853	179	66	[	[	-LRB-
cord-322966-o65fo853	179	67	29	29	CD
cord-322966-o65fo853	179	68	]	]	-RRB-
cord-322966-o65fo853	179	69	[	[	-LRB-
cord-322966-o65fo853	179	70	30	30	CD
cord-322966-o65fo853	179	71	]	]	-RRB-
cord-322966-o65fo853	179	72	.	.	.
cord-322966-o65fo853	180	1	In	in	IN
cord-322966-o65fo853	180	2	managing	manage	VBG
cord-322966-o65fo853	180	3	a	a	DT
cord-322966-o65fo853	180	4	global	global	JJ
cord-322966-o65fo853	180	5	pandemic	pandemic	NN
cord-322966-o65fo853	180	6	with	with	IN
cord-322966-o65fo853	180	7	a	a	DT
cord-322966-o65fo853	180	8	high	high	JJ
cord-322966-o65fo853	180	9	death	death	NN
cord-322966-o65fo853	180	10	rate	rate	NN
cord-322966-o65fo853	180	11	,	,	,
cord-322966-o65fo853	180	12	treatments	treatment	NNS
cord-322966-o65fo853	180	13	aimed	aim	VBN
cord-322966-o65fo853	180	14	at	at	IN
cord-322966-o65fo853	180	15	the	the	DT
cord-322966-o65fo853	180	16	fundamental	fundamental	JJ
cord-322966-o65fo853	180	17	pathology	pathology	NN
cord-322966-o65fo853	180	18	,	,	,
cord-322966-o65fo853	180	19	that	that	WDT
cord-322966-o65fo853	180	20	can	can	MD
cord-322966-o65fo853	180	21	meet	meet	VB
cord-322966-o65fo853	180	22	the	the	DT
cord-322966-o65fo853	180	23	scale	scale	NN
cord-322966-o65fo853	180	24	of	of	IN
cord-322966-o65fo853	180	25	the	the	DT
cord-322966-o65fo853	180	26	problem	problem	NN
cord-322966-o65fo853	180	27	,	,	,
cord-322966-o65fo853	180	28	are	be	VBP
cord-322966-o65fo853	180	29	an	an	DT
cord-322966-o65fo853	180	30	appealing	appealing	JJ
cord-322966-o65fo853	180	31	option	option	NN
cord-322966-o65fo853	180	32	.	.	.
cord-322966-o65fo853	181	1	Data	datum	NNS
cord-322966-o65fo853	181	2	from	from	IN
cord-322966-o65fo853	181	3	randomised	randomised	JJ
cord-322966-o65fo853	181	4	clinical	clinical	JJ
cord-322966-o65fo853	181	5	trials	trial	NNS
cord-322966-o65fo853	181	6	examining	examine	VBG
cord-322966-o65fo853	181	7	a	a	DT
cord-322966-o65fo853	181	8	broader	broad	JJR
cord-322966-o65fo853	181	9	role	role	NN
cord-322966-o65fo853	181	10	for	for	IN
cord-322966-o65fo853	181	11	RAS	RAS	NNP
cord-322966-o65fo853	181	12	agents	agent	NNS
cord-322966-o65fo853	181	13	in	in	IN
cord-322966-o65fo853	181	14	COVID-19	COVID-19	NNP
cord-322966-o65fo853	181	15	,	,	,
cord-322966-o65fo853	181	16	beyond	beyond	IN
cord-322966-o65fo853	181	17	existing	exist	VBG
cord-322966-o65fo853	181	18	indications	indication	NNS
cord-322966-o65fo853	181	19	,	,	,
cord-322966-o65fo853	181	20	is	be	VBZ
cord-322966-o65fo853	181	21	awaited	await	VBN
cord-322966-o65fo853	181	22	and	and	CC
cord-322966-o65fo853	181	23	will	will	MD
cord-322966-o65fo853	181	24	further	further	RB
cord-322966-o65fo853	181	25	define	define	VB
cord-322966-o65fo853	181	26	the	the	DT
cord-322966-o65fo853	181	27	role	role	NN
cord-322966-o65fo853	181	28	of	of	IN
cord-322966-o65fo853	181	29	these	these	DT
cord-322966-o65fo853	181	30	medications	medication	NNS
cord-322966-o65fo853	181	31	.	.	.
cord-322966-o65fo853	182	1	Clinical	clinical	JJ
cord-322966-o65fo853	182	2	course	course	NN
cord-322966-o65fo853	182	3	and	and	CC
cord-322966-o65fo853	182	4	risk	risk	NN
cord-322966-o65fo853	182	5	factors	factor	NNS
cord-322966-o65fo853	182	6	for	for	IN
cord-322966-o65fo853	182	7	mortality	mortality	NN
cord-322966-o65fo853	182	8	of	of	IN
cord-322966-o65fo853	182	9	adult	adult	NN
cord-322966-o65fo853	182	10	inpatients	inpatient	NNS
cord-322966-o65fo853	182	11	with	with	IN
cord-322966-o65fo853	182	12	COVID-19	COVID-19	NNP
cord-322966-o65fo853	182	13	in	in	IN
cord-322966-o65fo853	182	14	Wuhan	Wuhan	NNP
cord-322966-o65fo853	182	15	,	,	,
cord-322966-o65fo853	182	16	China	China	NNP
cord-322966-o65fo853	182	17	:	:	:
cord-322966-o65fo853	182	18	a	a	DT
cord-322966-o65fo853	182	19	retrospective	retrospective	JJ
cord-322966-o65fo853	182	20	cohort	cohort	NN
cord-322966-o65fo853	182	21	study	study	NN
cord-322966-o65fo853	182	22	Novel	Novel	NNP
cord-322966-o65fo853	182	23	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	182	24	Pneumonia	Pneumonia	NNP
cord-322966-o65fo853	182	25	Emergency	Emergency	NNP
cord-322966-o65fo853	182	26	Response	Response	NNP
cord-322966-o65fo853	182	27	Epidemiology	Epidemiology	NNP
cord-322966-o65fo853	182	28	Team	Team	NNP
cord-322966-o65fo853	182	29	.	.	.
cord-322966-o65fo853	183	1	The	the	DT
cord-322966-o65fo853	183	2	epidemiological	epidemiological	JJ
cord-322966-o65fo853	183	3	characteristics	characteristic	NNS
cord-322966-o65fo853	183	4	of	of	IN
cord-322966-o65fo853	183	5	an	an	DT
cord-322966-o65fo853	183	6	outbreak	outbreak	NN
cord-322966-o65fo853	183	7	of	of	IN
cord-322966-o65fo853	183	8	2019	2019	CD
cord-322966-o65fo853	183	9	novel	novel	JJ
cord-322966-o65fo853	183	10	coronavirus	coronavirus	NN
cord-322966-o65fo853	183	11	diseases	disease	NNS
cord-322966-o65fo853	183	12	Angiotensin	Angiotensin	NNP
cord-322966-o65fo853	183	13	-	-	HYPH
cord-322966-o65fo853	183	14	converting	convert	VBG
cord-322966-o65fo853	183	15	enzyme	enzyme	NN
cord-322966-o65fo853	183	16	2	2	CD
cord-322966-o65fo853	183	17	(	(	-LRB-
cord-322966-o65fo853	183	18	ACE2	ACE2	NNP
cord-322966-o65fo853	183	19	)	)	-RRB-
cord-322966-o65fo853	183	20	as	as	IN
cord-322966-o65fo853	183	21	a	a	DT
cord-322966-o65fo853	183	22	SARS	SARS	NNP
cord-322966-o65fo853	183	23	-	-	HYPH
cord-322966-o65fo853	183	24	CoV-2	CoV-2	NNP
cord-322966-o65fo853	183	25	receptor	receptor	NN
cord-322966-o65fo853	183	26	:	:	:
cord-322966-o65fo853	183	27	molecular	molecular	JJ
cord-322966-o65fo853	183	28	mechanisms	mechanism	NNS
cord-322966-o65fo853	183	29	and	and	CC
cord-322966-o65fo853	183	30	potential	potential	JJ
cord-322966-o65fo853	183	31	therapeutic	therapeutic	JJ
cord-322966-o65fo853	183	32	target	target	NN
cord-322966-o65fo853	183	33	Renin	renin	NN
cord-322966-o65fo853	183	34	-	-	HYPH
cord-322966-o65fo853	183	35	angiotensin	angiotensin	NN
cord-322966-o65fo853	183	36	system	system	NN
cord-322966-o65fo853	183	37	in	in	IN
cord-322966-o65fo853	183	38	human	human	JJ
cord-322966-o65fo853	183	39	coronavirus	coronavirus	NN
cord-322966-o65fo853	183	40	pathogenesis	pathogenesis	NN
cord-322966-o65fo853	183	41	Replication	replication	NN
cord-322966-o65fo853	183	42	dependent	dependent	JJ
cord-322966-o65fo853	183	43	downregulation	downregulation	NN
cord-322966-o65fo853	183	44	of	of	IN
cord-322966-o65fo853	183	45	cellular	cellular	JJ
cord-322966-o65fo853	183	46	angiotensin	angiotensin	NN
cord-322966-o65fo853	183	47	-	-	HYPH
cord-322966-o65fo853	183	48	converting	convert	VBG
cord-322966-o65fo853	183	49	enzyme	enzyme	NN
cord-322966-o65fo853	183	50	2	2	CD
cord-322966-o65fo853	183	51	protein	protein	NN
cord-322966-o65fo853	183	52	expression	expression	NN
cord-322966-o65fo853	183	53	by	by	IN
cord-322966-o65fo853	183	54	human	human	JJ
cord-322966-o65fo853	183	55	coronavirus	coronavirus	NN
cord-322966-o65fo853	183	56	NL63	NL63	NNP
cord-322966-o65fo853	183	57	Association	Association	NNP
cord-322966-o65fo853	183	58	of	of	IN
cord-322966-o65fo853	183	59	ACE2	ACE2	NNP
cord-322966-o65fo853	183	60	genetic	genetic	JJ
cord-322966-o65fo853	183	61	polymorphisms	polymorphism	NNS
cord-322966-o65fo853	183	62	with	with	IN
cord-322966-o65fo853	183	63	hypertension	hypertension	NN
cord-322966-o65fo853	183	64	-	-	HYPH
cord-322966-o65fo853	183	65	related	relate	VBN
cord-322966-o65fo853	183	66	target	target	NN
cord-322966-o65fo853	183	67	organ	organ	NN
cord-322966-o65fo853	183	68	damages	damage	NNS
cord-322966-o65fo853	183	69	in	in	IN
cord-322966-o65fo853	183	70	south	south	JJ
cord-322966-o65fo853	183	71	Xinjiang	Xinjiang	NNP
cord-322966-o65fo853	183	72	Individual	Individual	NNP
cord-322966-o65fo853	183	73	variation	variation	NN
cord-322966-o65fo853	183	74	of	of	IN
cord-322966-o65fo853	183	75	the	the	DT
cord-322966-o65fo853	183	76	SARS	SARS	NNP
cord-322966-o65fo853	183	77	-	-	HYPH
cord-322966-o65fo853	183	78	CoV2	CoV2	NNP
cord-322966-o65fo853	183	79	receptor	receptor	NN
cord-322966-o65fo853	183	80	ACE2	ACE2	NNP
cord-322966-o65fo853	183	81	gene	gene	NN
cord-322966-o65fo853	183	82	expression	expression	NN
cord-322966-o65fo853	183	83	and	and	CC
cord-322966-o65fo853	183	84	regulation	regulation	NN
cord-322966-o65fo853	183	85	WHO	WHO	NNP
cord-322966-o65fo853	183	86	data	datum	NNS
cord-322966-o65fo853	183	87	as	as	IN
cord-322966-o65fo853	183	88	presented	present	VBN
cord-322966-o65fo853	183	89	on	on	IN
cord-322966-o65fo853	183	90	Worldometer	Worldometer	NNP
cord-322966-o65fo853	183	91	website	website	NN
cord-322966-o65fo853	183	92	Cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	183	93	disease	disease	NN
cord-322966-o65fo853	183	94	,	,	,
cord-322966-o65fo853	183	95	Drug	drug	NN
cord-322966-o65fo853	183	96	therapy	therapy	NN
cord-322966-o65fo853	183	97	,	,	,
cord-322966-o65fo853	183	98	and	and	CC
cord-322966-o65fo853	183	99	mortality	mortality	NN
cord-322966-o65fo853	183	100	in	in	IN
cord-322966-o65fo853	183	101	Covid-19	Covid-19	NNP
cord-322966-o65fo853	183	102	Position	Position	NNP
cord-322966-o65fo853	183	103	Statement	Statement	NNP
cord-322966-o65fo853	183	104	of	of	IN
cord-322966-o65fo853	183	105	the	the	DT
cord-322966-o65fo853	183	106	ESC	ESC	NNP
cord-322966-o65fo853	183	107	Council	Council	NNP
cord-322966-o65fo853	183	108	on	on	IN
cord-322966-o65fo853	183	109	Hypertension	Hypertension	NNP
cord-322966-o65fo853	183	110	on	on	IN
cord-322966-o65fo853	183	111	ACE	ACE	NNP
cord-322966-o65fo853	183	112	-	-	HYPH
cord-322966-o65fo853	183	113	Inhibitors	Inhibitors	NNP
cord-322966-o65fo853	183	114	and	and	CC
cord-322966-o65fo853	183	115	Angiotensin	Angiotensin	NNP
cord-322966-o65fo853	183	116	Receptor	Receptor	NNP
cord-322966-o65fo853	183	117	Blockers	Blockers	NNP
cord-322966-o65fo853	183	118	.	.	.
cord-322966-o65fo853	184	1	13	13	CD
cord-322966-o65fo853	184	2	th	th	CD
cord-322966-o65fo853	184	3	Cardiovascular	Cardiovascular	NNP
cord-322966-o65fo853	184	4	disease	disease	NN
cord-322966-o65fo853	184	5	and	and	CC
cord-322966-o65fo853	184	6	COVID-19	covid-19	NN
cord-322966-o65fo853	184	7	:	:	:
cord-322966-o65fo853	184	8	Australian	Australian	NNP
cord-322966-o65fo853	184	9	/	/	SYM
cord-322966-o65fo853	184	10	New	New	NNP
cord-322966-o65fo853	184	11	Zealand	Zealand	NNP
cord-322966-o65fo853	184	12	consensus	consensus	NN
cord-322966-o65fo853	184	13	statement	statement	NN
cord-322966-o65fo853	184	14	Reninangiotensin	Reninangiotensin	NNP
cord-322966-o65fo853	184	15	-	-	HYPH
cord-322966-o65fo853	184	16	aldosterone	aldosterone	NN
cord-322966-o65fo853	184	17	system	system	NN
cord-322966-o65fo853	184	18	inhibitors	inhibitor	NNS
cord-322966-o65fo853	184	19	and	and	CC
cord-322966-o65fo853	184	20	risk	risk	NN
cord-322966-o65fo853	184	21	of	of	IN
cord-322966-o65fo853	184	22	Covid-19	Covid-19	NNP
cord-322966-o65fo853	184	23	Renin	Renin	NNP
cord-322966-o65fo853	184	24	-	-	HYPH
cord-322966-o65fo853	184	25	angiotensin	angiotensin	NN
cord-322966-o65fo853	184	26	-	-	HYPH
cord-322966-o65fo853	184	27	aldosterone	aldosterone	NN
cord-322966-o65fo853	184	28	system	system	NN
cord-322966-o65fo853	184	29	blockers	blocker	NNS
cord-322966-o65fo853	184	30	and	and	CC
cord-322966-o65fo853	184	31	the	the	DT
cord-322966-o65fo853	184	32	risk	risk	NN
cord-322966-o65fo853	184	33	of	of	IN
cord-322966-o65fo853	184	34	Covid-19	Covid-19	NNP
cord-322966-o65fo853	184	35	Angiotensin	Angiotensin	NNP
cord-322966-o65fo853	184	36	receptor	receptor	NN
cord-322966-o65fo853	184	37	blockers	blocker	NNS
cord-322966-o65fo853	184	38	as	as	IN
cord-322966-o65fo853	184	39	tentative	tentative	JJ
cord-322966-o65fo853	184	40	SARS	SARS	NNP
cord-322966-o65fo853	184	41	-	-	HYPH
cord-322966-o65fo853	184	42	CoV-2	CoV-2	NNP
cord-322966-o65fo853	184	43	therapeutics	therapeutic	NNS
cord-322966-o65fo853	184	44	Clinical	clinical	JJ
cord-322966-o65fo853	184	45	implications	implication	NNS
cord-322966-o65fo853	184	46	of	of	IN
cord-322966-o65fo853	184	47	SARS	SARS	NNP
cord-322966-o65fo853	184	48	-	-	HYPH
cord-322966-o65fo853	184	49	Cov2	Cov2	NNP
cord-322966-o65fo853	184	50	interaction	interaction	NN
cord-322966-o65fo853	184	51	with	with	IN
cord-322966-o65fo853	184	52	renin	renin	NN
cord-322966-o65fo853	184	53	angiotensin	angiotensin	NN
cord-322966-o65fo853	184	54	system	system	NN
cord-322966-o65fo853	185	1	Vitamin	vitamin	NN
cord-322966-o65fo853	185	2	D	d	NN
cord-322966-o65fo853	185	3	insufficiency	insufficiency	NN
cord-322966-o65fo853	185	4	is	be	VBZ
cord-322966-o65fo853	185	5	prevalent	prevalent	JJ
cord-322966-o65fo853	185	6	in	in	IN
cord-322966-o65fo853	185	7	severe	severe	JJ
cord-322966-o65fo853	185	8	COVID-19	COVID-19	NNP
cord-322966-o65fo853	185	9	Angiotensin	Angiotensin	NNP
cord-322966-o65fo853	185	10	-	-	HYPH
cord-322966-o65fo853	185	11	converting	convert	VBG
cord-322966-o65fo853	185	12	enzyme	enzyme	NN
cord-322966-o65fo853	185	13	in	in	IN
cord-322966-o65fo853	185	14	innate	innate	JJ
cord-322966-o65fo853	185	15	and	and	CC
cord-322966-o65fo853	185	16	adaptive	adaptive	JJ
cord-322966-o65fo853	185	17	immunity	immunity	NN
cord-322966-o65fo853	185	18	Vitamin	vitamin	NN
cord-322966-o65fo853	185	19	D	d	NN
cord-322966-o65fo853	185	20	and	and	CC
cord-322966-o65fo853	185	21	the	the	DT
cord-322966-o65fo853	185	22	immune	immune	JJ
cord-322966-o65fo853	185	23	system	system	NN
cord-322966-o65fo853	185	24	Meta	Meta	NNP
cord-322966-o65fo853	185	25	-	-	HYPH
cord-322966-o65fo853	185	26	analysis	analysis	NN
cord-322966-o65fo853	185	27	on	on	IN
cord-322966-o65fo853	185	28	troponin	troponin	JJ
cord-322966-o65fo853	185	29	I	-PRON-	PRP
cord-322966-o65fo853	185	30	in	in	IN
cord-322966-o65fo853	185	31	patients	patient	NNS
cord-322966-o65fo853	185	32	with	with	IN
cord-322966-o65fo853	185	33	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	185	34	disease	disease	NN
cord-322966-o65fo853	185	35	2019	2019	CD
cord-322966-o65fo853	185	36	(	(	-LRB-
cord-322966-o65fo853	185	37	COVID-10	covid-10	NN
cord-322966-o65fo853	185	38	)	)	-RRB-
cord-322966-o65fo853	186	1	:	:	:
cord-322966-o65fo853	186	2	evidence	evidence	NN
cord-322966-o65fo853	186	3	from	from	IN
cord-322966-o65fo853	186	4	a	a	DT
cord-322966-o65fo853	186	5	meta	meta	JJ
cord-322966-o65fo853	186	6	-	-	HYPH
cord-322966-o65fo853	186	7	analysis	analysis	NN
cord-322966-o65fo853	186	8	Role	role	NN
cord-322966-o65fo853	186	9	of	of	IN
cord-322966-o65fo853	186	10	the	the	DT
cord-322966-o65fo853	186	11	ACE2/	ACE2/	NNP
cord-322966-o65fo853	187	1	Angiotensin	angiotensin	NN
cord-322966-o65fo853	187	2	1	1	CD
cord-322966-o65fo853	187	3	-	-	SYM
cord-322966-o65fo853	187	4	7	7	CD
cord-322966-o65fo853	187	5	axis	axis	NN
cord-322966-o65fo853	187	6	of	of	IN
cord-322966-o65fo853	187	7	the	the	DT
cord-322966-o65fo853	187	8	reninangiotensin	reninangiotensin	JJ
cord-322966-o65fo853	187	9	system	system	NN
cord-322966-o65fo853	187	10	in	in	IN
cord-322966-o65fo853	187	11	heart	heart	NN
cord-322966-o65fo853	187	12	failure	failure	NN
cord-322966-o65fo853	187	13	Detection	detection	NN
cord-322966-o65fo853	187	14	of	of	IN
cord-322966-o65fo853	187	15	soluble	soluble	JJ
cord-322966-o65fo853	187	16	angiotensinconverting	angiotensinconverting	NN
cord-322966-o65fo853	187	17	enzyme	enzyme	NN
cord-322966-o65fo853	187	18	2	2	CD
cord-322966-o65fo853	187	19	in	in	IN
cord-322966-o65fo853	187	20	heart	heart	NN
cord-322966-o65fo853	187	21	failure	failure	NN
cord-322966-o65fo853	188	1	Circulating	circulate	VBG
cord-322966-o65fo853	188	2	ACE-2	ACE-2	NNP
cord-322966-o65fo853	188	3	activity	activity	NN
cord-322966-o65fo853	188	4	correlated	correlate	VBN
cord-322966-o65fo853	188	5	with	with	IN
cord-322966-o65fo853	188	6	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	188	7	disease	disease	NN
cord-322966-o65fo853	188	8	development	development	NN
cord-322966-o65fo853	188	9	Reninangiotensin	Reninangiotensin	NNP
cord-322966-o65fo853	188	10	-	-	HYPH
cord-322966-o65fo853	188	11	aldosterone	aldosterone	NN
cord-322966-o65fo853	188	12	system	system	NN
cord-322966-o65fo853	188	13	inhibitors	inhibitor	NNS
cord-322966-o65fo853	188	14	in	in	IN
cord-322966-o65fo853	188	15	patients	patient	NNS
cord-322966-o65fo853	188	16	with	with	IN
cord-322966-o65fo853	188	17	COVID-19	COVID-19	NNP
cord-322966-o65fo853	188	18	COVID-19	COVID-19	NNP
cord-322966-o65fo853	188	19	and	and	CC
cord-322966-o65fo853	188	20	angiotensin	angiotensin	NN
cord-322966-o65fo853	188	21	-	-	HYPH
cord-322966-o65fo853	188	22	converting	convert	VBG
cord-322966-o65fo853	188	23	enzyme	enzyme	NN
cord-322966-o65fo853	188	24	inhibitors	inhibitor	NNS
cord-322966-o65fo853	188	25	and	and	CC
cord-322966-o65fo853	188	26	angiotensin	angiotensin	NN
cord-322966-o65fo853	188	27	receptor	receptor	NN
cord-322966-o65fo853	188	28	blockers	blocker	NNS
cord-322966-o65fo853	188	29	:	:	:
cord-322966-o65fo853	188	30	what	what	WP
cord-322966-o65fo853	188	31	is	be	VBZ
cord-322966-o65fo853	188	32	the	the	DT
cord-322966-o65fo853	188	33	evidence	evidence	NN
cord-322966-o65fo853	188	34	?	?	.
cord-322966-o65fo853	189	1	JAMA	JAMA	NNP
cord-322966-o65fo853	189	2	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	189	3	disease	disease	NN
cord-322966-o65fo853	189	4	2019	2019	CD
cord-322966-o65fo853	189	5	(	(	-LRB-
cord-322966-o65fo853	189	6	COVID-19	COVID-19	NNP
cord-322966-o65fo853	189	7	)	)	-RRB-
cord-322966-o65fo853	189	8	:	:	:
cord-322966-o65fo853	190	1	do	do	VB
cord-322966-o65fo853	190	2	angiotensin	angiotensin	NN
cord-322966-o65fo853	190	3	-	-	HYPH
cord-322966-o65fo853	190	4	converting	convert	VBG
cord-322966-o65fo853	190	5	enzyme	enzyme	NN
cord-322966-o65fo853	190	6	inhibitors	inhibitor	NNS
cord-322966-o65fo853	190	7	/	/	SYM
cord-322966-o65fo853	190	8	angiotensin	angiotensin	NN
cord-322966-o65fo853	190	9	receptor	receptor	NN
cord-322966-o65fo853	190	10	blockers	blocker	NNS
cord-322966-o65fo853	190	11	have	have	VBP
cord-322966-o65fo853	190	12	a	a	DT
cord-322966-o65fo853	190	13	biphasic	biphasic	JJ
cord-322966-o65fo853	190	14	effect	effect	NN
cord-322966-o65fo853	190	15	?	?	.
cord-322966-o65fo853	191	1	Angiotensin	angiotensin	NN
cord-322966-o65fo853	191	2	converting	convert	VBG
cord-322966-o65fo853	191	3	enzyme	enzyme	NN
cord-322966-o65fo853	191	4	2	2	CD
cord-322966-o65fo853	191	5	:	:	:
cord-322966-o65fo853	191	6	a	a	DT
cord-322966-o65fo853	191	7	double	double	RB
cord-322966-o65fo853	191	8	-	-	HYPH
cord-322966-o65fo853	191	9	edged	edged	JJ
cord-322966-o65fo853	191	10	sword	sword	NN
cord-322966-o65fo853	191	11	Association	Association	NNP
cord-322966-o65fo853	191	12	of	of	IN
cord-322966-o65fo853	191	13	inpatient	inpatient	JJ
cord-322966-o65fo853	191	14	use	use	NN
cord-322966-o65fo853	191	15	of	of	IN
cord-322966-o65fo853	191	16	angiotensin	angiotensin	NN
cord-322966-o65fo853	191	17	converting	convert	VBG
cord-322966-o65fo853	191	18	enzyme	enzyme	NN
cord-322966-o65fo853	191	19	inhibitors	inhibitor	NNS
cord-322966-o65fo853	191	20	and	and	CC
cord-322966-o65fo853	191	21	angiotensin	angiotensin	NNP
cord-322966-o65fo853	191	22	ii	ii	CD
cord-322966-o65fo853	191	23	receptor	receptor	NN
cord-322966-o65fo853	191	24	blockers	blocker	NNS
cord-322966-o65fo853	191	25	with	with	IN
cord-322966-o65fo853	191	26	mortality	mortality	NN
cord-322966-o65fo853	191	27	among	among	IN
cord-322966-o65fo853	191	28	patients	patient	NNS
cord-322966-o65fo853	191	29	with	with	IN
cord-322966-o65fo853	191	30	hypertension	hypertension	NN
cord-322966-o65fo853	191	31	hospitalized	hospitalize	VBN
cord-322966-o65fo853	191	32	with	with	IN
cord-322966-o65fo853	191	33	COVID-19	COVID-19	NNP
cord-322966-o65fo853	191	34	Association	Association	NNP
cord-322966-o65fo853	191	35	of	of	IN
cord-322966-o65fo853	191	36	renin	renin	NN
cord-322966-o65fo853	191	37	-	-	HYPH
cord-322966-o65fo853	191	38	angiotensin	angiotensin	NN
cord-322966-o65fo853	191	39	system	system	NN
cord-322966-o65fo853	192	1	inhibitorswith	inhibitorswith	NNP
cord-322966-o65fo853	192	2	severity	severity	NN
cord-322966-o65fo853	192	3	or	or	CC
cord-322966-o65fo853	192	4	risk	risk	NN
cord-322966-o65fo853	192	5	of	of	IN
cord-322966-o65fo853	192	6	death	death	NN
cord-322966-o65fo853	192	7	in	in	IN
cord-322966-o65fo853	192	8	patients	patient	NNS
cord-322966-o65fo853	192	9	with	with	IN
cord-322966-o65fo853	192	10	hypertension	hypertension	NN
cord-322966-o65fo853	192	11	hospitalised	hospitalise	VBN
cord-322966-o65fo853	192	12	for	for	IN
cord-322966-o65fo853	192	13	coronavirus	coronavirus	NN
cord-322966-o65fo853	192	14	disease	disease	NN
cord-322966-o65fo853	192	15	19	19	CD
cord-322966-o65fo853	192	16	(	(	-LRB-
cord-322966-o65fo853	193	1	COVID-19	covid-19	LS
cord-322966-o65fo853	193	2	)	)	-RRB-
cord-322966-o65fo853	193	3	infection	infection	NN
cord-322966-o65fo853	193	4	in	in	IN
cord-322966-o65fo853	193	5	Wuhan	Wuhan	NNP
cord-322966-o65fo853	193	6	,	,	,
cord-322966-o65fo853	193	7	China	China	NNP
cord-322966-o65fo853	193	8	Treatment	Treatment	NNP
cord-322966-o65fo853	193	9	with	with	IN
cord-322966-o65fo853	193	10	ACEinhibitors	aceinhibitor	NNS
cord-322966-o65fo853	193	11	is	be	VBZ
cord-322966-o65fo853	193	12	associated	associate	VBN
cord-322966-o65fo853	193	13	with	with	IN
cord-322966-o65fo853	193	14	less	less	RBR
cord-322966-o65fo853	193	15	severe	severe	JJ
cord-322966-o65fo853	193	16	disease	disease	NN
cord-322966-o65fo853	193	17	with	with	IN
cord-322966-o65fo853	193	18	SARS	SARS	NNP
cord-322966-o65fo853	193	19	-	-	HYPH
cord-322966-o65fo853	193	20	Covid-19	Covid-19	NNP
cord-322966-o65fo853	193	21	infection	infection	NN
cord-322966-o65fo853	193	22	in	in	IN
cord-322966-o65fo853	193	23	a	a	DT
cord-322966-o65fo853	193	24	multi	multi	JJ
cord-322966-o65fo853	193	25	-	-	JJ
cord-322966-o65fo853	193	26	site	site	JJ
cord-322966-o65fo853	193	27	UK	UK	NNP
cord-322966-o65fo853	193	28	acute	acute	JJ
cord-322966-o65fo853	193	29	hospital	hospital	NN
cord-322966-o65fo853	193	30	trust	trust	NNP
cord-322966-o65fo853	193	31	Association	Association	NNP
cord-322966-o65fo853	193	32	of	of	IN
cord-322966-o65fo853	193	33	ACE2	ACE2	NNP
cord-322966-o65fo853	193	34	Genetic	Genetic	NNP
cord-322966-o65fo853	193	35	variants	variant	NNS
cord-322966-o65fo853	193	36	with	with	IN
cord-322966-o65fo853	193	37	blood	blood	NN
cord-322966-o65fo853	193	38	pressure	pressure	NN
cord-322966-o65fo853	193	39	,	,	,
cord-322966-o65fo853	193	40	left	leave	VBD
cord-322966-o65fo853	193	41	ventricular	ventricular	JJ
cord-322966-o65fo853	193	42	mass	mass	NN
cord-322966-o65fo853	193	43	and	and	CC
cord-322966-o65fo853	193	44	cardiac	cardiac	JJ
cord-322966-o65fo853	193	45	function	function	NN
cord-322966-o65fo853	193	46	in	in	IN
cord-322966-o65fo853	193	47	Caucasians	Caucasians	NNPS
cord-322966-o65fo853	193	48	with	with	IN
cord-322966-o65fo853	193	49	type	type	NN
cord-322966-o65fo853	193	50	2	2	CD
cord-322966-o65fo853	193	51	diabetes	diabete	VBZ
cord-322966-o65fo853	193	52	Protective	protective	JJ
cord-322966-o65fo853	193	53	regulation	regulation	NN
cord-322966-o65fo853	193	54	of	of	IN
cord-322966-o65fo853	193	55	the	the	DT
cord-322966-o65fo853	193	56	ACE2	ACE2	NNP
cord-322966-o65fo853	193	57	/	/	SYM
cord-322966-o65fo853	193	58	ACE	ACE	NNP
cord-322966-o65fo853	193	59	gene	gene	NN
cord-322966-o65fo853	193	60	expression	expression	NN
cord-322966-o65fo853	193	61	by	by	IN
cord-322966-o65fo853	193	62	estrogen	estrogen	NN
cord-322966-o65fo853	193	63	in	in	IN
cord-322966-o65fo853	193	64	human	human	JJ
cord-322966-o65fo853	193	65	atrial	atrial	JJ
cord-322966-o65fo853	193	66	tissue	tissue	NN
cord-322966-o65fo853	193	67	from	from	IN
cord-322966-o65fo853	193	68	elderly	elderly	JJ
cord-322966-o65fo853	193	69	men	man	NNS
cord-322966-o65fo853	194	1	Sex	sex	NN
cord-322966-o65fo853	194	2	drives	drive	VBZ
cord-322966-o65fo853	194	3	dimorphic	dimorphic	JJ
cord-322966-o65fo853	194	4	immune	immune	JJ
cord-322966-o65fo853	194	5	responses	response	NNS
cord-322966-o65fo853	194	6	to	to	IN
cord-322966-o65fo853	194	7	viral	viral	JJ
cord-322966-o65fo853	194	8	infections	infection	NNS
cord-322966-o65fo853	194	9	Nicotine	nicotine	NN
cord-322966-o65fo853	194	10	and	and	CC
cord-322966-o65fo853	194	11	the	the	DT
cord-322966-o65fo853	194	12	renin	renin	NN
cord-322966-o65fo853	194	13	angiotensin	angiotensin	NN
cord-322966-o65fo853	194	14	system	system	NN
cord-322966-o65fo853	194	15	Clinical	Clinical	NNP
cord-322966-o65fo853	194	16	Features	feature	NNS
cord-322966-o65fo853	194	17	of	of	IN
cord-322966-o65fo853	194	18	patients	patient	NNS
cord-322966-o65fo853	194	19	infected	infect	VBN
cord-322966-o65fo853	194	20	with	with	IN
cord-322966-o65fo853	194	21	2019	2019	CD
cord-322966-o65fo853	194	22	novel	novel	JJ
cord-322966-o65fo853	194	23	coronavirus	coronavirus	NN
cord-322966-o65fo853	194	24	in	in	IN
cord-322966-o65fo853	194	25	Wuhan	Wuhan	NNP
cord-322966-o65fo853	194	26	,	,	,
cord-322966-o65fo853	194	27	China	China	NNP
cord-322966-o65fo853	194	28	China	China	NNP
cord-322966-o65fo853	194	29	Medical	Medical	NNP
cord-322966-o65fo853	194	30	Treatment	Treatment	NNP
cord-322966-o65fo853	194	31	Expert	Expert	NNP
cord-322966-o65fo853	194	32	Group	Group	NNP
cord-322966-o65fo853	194	33	for	for	IN
cord-322966-o65fo853	194	34	Covid-19	Covid-19	NNP
cord-322966-o65fo853	194	35	.	.	.
cord-322966-o65fo853	195	1	Clinical	clinical	JJ
cord-322966-o65fo853	195	2	characteristics	characteristic	NNS
cord-322966-o65fo853	195	3	of	of	IN
cord-322966-o65fo853	195	4	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	195	5	disease	disease	NN
cord-322966-o65fo853	195	6	2019	2019	CD
cord-322966-o65fo853	195	7	in	in	IN
cord-322966-o65fo853	195	8	China	China	NNP
cord-322966-o65fo853	195	9	Clinical	clinical	JJ
cord-322966-o65fo853	195	10	characteristics	characteristic	NNS
cord-322966-o65fo853	195	11	of	of	IN
cord-322966-o65fo853	195	12	140	140	CD
cord-322966-o65fo853	195	13	patients	patient	NNS
cord-322966-o65fo853	195	14	infected	infect	VBN
cord-322966-o65fo853	195	15	with	with	IN
cord-322966-o65fo853	195	16	SARS	SARS	NNP
cord-322966-o65fo853	195	17	-	-	HYPH
cord-322966-o65fo853	195	18	CoV	CoV	NNP
cord-322966-o65fo853	195	19	in	in	IN
cord-322966-o65fo853	195	20	Wuhan	Wuhan	NNP
cord-322966-o65fo853	195	21	,	,	,
cord-322966-o65fo853	195	22	China	China	NNP
cord-322966-o65fo853	195	23	Soluble	soluble	JJ
cord-322966-o65fo853	195	24	neprilysin	neprilysin	NN
cord-322966-o65fo853	195	25	in	in	IN
cord-322966-o65fo853	195	26	the	the	DT
cord-322966-o65fo853	195	27	general	general	JJ
cord-322966-o65fo853	195	28	population	population	NN
cord-322966-o65fo853	195	29	:	:	:
cord-322966-o65fo853	195	30	clinical	clinical	JJ
cord-322966-o65fo853	195	31	determinants	determinant	NNS
cord-322966-o65fo853	195	32	and	and	CC
cord-322966-o65fo853	195	33	its	-PRON-	PRP$
cord-322966-o65fo853	195	34	relationship	relationship	NN
cord-322966-o65fo853	195	35	to	to	IN
cord-322966-o65fo853	195	36	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	195	37	disease	disease	NN
cord-322966-o65fo853	195	38	Hypokalemia	Hypokalemia	NNP
cord-322966-o65fo853	195	39	and	and	CC
cord-322966-o65fo853	195	40	clinical	clinical	JJ
cord-322966-o65fo853	195	41	implications	implication	NNS
cord-322966-o65fo853	195	42	in	in	IN
cord-322966-o65fo853	195	43	patients	patient	NNS
cord-322966-o65fo853	195	44	with	with	IN
cord-322966-o65fo853	195	45	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	195	46	Disease	Disease	NNP
cord-322966-o65fo853	195	47	2019	2019	CD
cord-322966-o65fo853	195	48	(	(	-LRB-
cord-322966-o65fo853	196	1	COVID-19	covid-19	LS
cord-322966-o65fo853	196	2	)	)	-RRB-
cord-322966-o65fo853	196	3	Hypokalemia	Hypokalemia	NNP
cord-322966-o65fo853	196	4	and	and	CC
cord-322966-o65fo853	196	5	clinical	clinical	JJ
cord-322966-o65fo853	196	6	implications	implication	NNS
cord-322966-o65fo853	196	7	in	in	IN
cord-322966-o65fo853	196	8	patients	patient	NNS
cord-322966-o65fo853	196	9	with	with	IN
cord-322966-o65fo853	196	10	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	196	11	disease	disease	NN
cord-322966-o65fo853	196	12	2019	2019	CD
cord-322966-o65fo853	196	13	(	(	-LRB-
cord-322966-o65fo853	196	14	COVID-19	COVID-19	NNP
cord-322966-o65fo853	196	15	)	)	-RRB-
cord-322966-o65fo853	196	16	Pulmonary	pulmonary	JJ
cord-322966-o65fo853	196	17	and	and	CC
cord-322966-o65fo853	196	18	cardiac	cardiac	JJ
cord-322966-o65fo853	196	19	pathology	pathology	NN
cord-322966-o65fo853	196	20	in	in	IN
cord-322966-o65fo853	196	21	COVID-19	COVID-19	NNP
cord-322966-o65fo853	196	22	:	:	:
cord-322966-o65fo853	196	23	the	the	DT
cord-322966-o65fo853	196	24	first	first	JJ
cord-322966-o65fo853	196	25	autopsy	autopsy	JJ
cord-322966-o65fo853	196	26	series	series	NN
cord-322966-o65fo853	196	27	from	from	IN
cord-322966-o65fo853	196	28	New	New	NNP
cord-322966-o65fo853	196	29	Orleans	Orleans	NNP
cord-322966-o65fo853	196	30	Clinical	Clinical	NNP
cord-322966-o65fo853	196	31	and	and	CC
cord-322966-o65fo853	196	32	biochemical	biochemical	JJ
cord-322966-o65fo853	196	33	indexes	index	NNS
cord-322966-o65fo853	196	34	from	from	IN
cord-322966-o65fo853	196	35	2019-nCoV	2019-ncov	CD
cord-322966-o65fo853	196	36	infected	infect	VBN
cord-322966-o65fo853	196	37	patients	patient	NNS
cord-322966-o65fo853	196	38	linked	link	VBN
cord-322966-o65fo853	196	39	to	to	IN
cord-322966-o65fo853	196	40	viral	viral	JJ
cord-322966-o65fo853	196	41	loads	load	NNS
cord-322966-o65fo853	196	42	and	and	CC
cord-322966-o65fo853	196	43	lung	lung	NN
cord-322966-o65fo853	196	44	injury	injury	NN
cord-322966-o65fo853	196	45	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	196	46	disease	disease	NN
cord-322966-o65fo853	196	47	2019	2019	CD
cord-322966-o65fo853	196	48	(	(	-LRB-
cord-322966-o65fo853	196	49	COVID-19	COVID-19	NNP
cord-322966-o65fo853	196	50	)	)	-RRB-
cord-322966-o65fo853	196	51	and	and	CC
cord-322966-o65fo853	196	52	cardiovascular	cardiovascular	JJ
cord-322966-o65fo853	196	53	Disease	Disease	NNP
cord-322966-o65fo853	196	54	:	:	:
cord-322966-o65fo853	196	55	a	a	DT
cord-322966-o65fo853	196	56	viewpoint	viewpoint	NN
cord-322966-o65fo853	196	57	on	on	IN
cord-322966-o65fo853	196	58	the	the	DT
cord-322966-o65fo853	196	59	potential	potential	JJ
cord-322966-o65fo853	196	60	influence	influence	NN
cord-322966-o65fo853	196	61	of	of	IN
cord-322966-o65fo853	196	62	angiotensin	angiotensin	NN
cord-322966-o65fo853	196	63	-	-	HYPH
cord-322966-o65fo853	196	64	converting	convert	VBG
cord-322966-o65fo853	196	65	enzyme	enzyme	NN
cord-322966-o65fo853	196	66	inhibitors	inhibitor	NNS
cord-322966-o65fo853	196	67	/	/	SYM
cord-322966-o65fo853	196	68	angiotensin	angiotensin	NN
cord-322966-o65fo853	196	69	receptor	receptor	NN
cord-322966-o65fo853	196	70	blockers	blocker	NNS
cord-322966-o65fo853	196	71	on	on	IN
cord-322966-o65fo853	196	72	onset	onset	NN
cord-322966-o65fo853	196	73	and	and	CC
cord-322966-o65fo853	196	74	severity	severity	NN
cord-322966-o65fo853	196	75	of	of	IN
cord-322966-o65fo853	196	76	severe	severe	JJ
cord-322966-o65fo853	196	77	acute	acute	JJ
cord-322966-o65fo853	196	78	respiratory	respiratory	JJ
cord-322966-o65fo853	196	79	syndrome	syndrome	NN
cord-322966-o65fo853	196	80	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	196	81	2	2	CD
cord-322966-o65fo853	196	82	infection	infection	NN
cord-322966-o65fo853	196	83	New	New	NNP
cord-322966-o65fo853	196	84	York	York	NNP
cord-322966-o65fo853	196	85	Times	Times	NNP
cord-322966-o65fo853	196	86	:	:	:
cord-322966-o65fo853	196	87	Coronavirus	Coronavirus	NNP
cord-322966-o65fo853	196	88	ravages	ravage	NNS
cord-322966-o65fo853	196	89	7	7	CD
cord-322966-o65fo853	196	90	members	member	NNS
cord-322966-o65fo853	196	91	of	of	IN
cord-322966-o65fo853	196	92	a	a	DT
cord-322966-o65fo853	196	93	single	single	JJ
cord-322966-o65fo853	196	94	family	family	NN
cord-322966-o65fo853	196	95	Host	host	NN
cord-322966-o65fo853	196	96	lipids	lipid	NNS
cord-322966-o65fo853	196	97	in	in	IN
cord-322966-o65fo853	196	98	positivestrand	positivestrand	NNP
cord-322966-o65fo853	196	99	RNA	RNA	NNP
cord-322966-o65fo853	196	100	virus	virus	NN
cord-322966-o65fo853	196	101	genome	genome	NN
cord-322966-o65fo853	196	102	replication	replication	NN
cord-322966-o65fo853	196	103	Characterization	characterization	NN
cord-322966-o65fo853	196	104	of	of	IN
cord-322966-o65fo853	196	105	lipidomic	lipidomic	NNP
cord-322966-o65fo853	196	106	profile	profile	NN
cord-322966-o65fo853	196	107	of	of	IN
cord-322966-o65fo853	196	108	human	human	JJ
cord-322966-o65fo853	196	109	coronavirus	coronavirus	NN
cord-322966-o65fo853	196	110	-	-	HYPH
cord-322966-o65fo853	196	111	infected	infect	VBN
cord-322966-o65fo853	196	112	cells	cell	NNS
cord-322966-o65fo853	196	113	:	:	:
cord-322966-o65fo853	197	1	Implications	implication	NNS
cord-322966-o65fo853	197	2	for	for	IN
cord-322966-o65fo853	197	3	lipid	lipid	NN
cord-322966-o65fo853	197	4	metabolism	metabolism	NN
cord-322966-o65fo853	197	5	remodelling	remodelling	NN
cord-322966-o65fo853	197	6	upon	upon	IN
cord-322966-o65fo853	197	7	coronavirus	coronavirus	NN
cord-322966-o65fo853	197	8	replication	replication	NN
cord-322966-o65fo853	197	9	Lysophosphatidylinositol	Lysophosphatidylinositol	NNP
cord-322966-o65fo853	197	10	signalling	signal	VBG
cord-322966-o65fo853	197	11	and	and	CC
cord-322966-o65fo853	197	12	metabolic	metabolic	JJ
cord-322966-o65fo853	197	13	diseases	disease	NNS
cord-322966-o65fo853	197	14	Chronic	chronic	VBP
cord-322966-o65fo853	197	15	widespread	widespread	JJ
cord-322966-o65fo853	197	16	musculoskeletal	musculoskeletal	JJ
cord-322966-o65fo853	197	17	pain	pain	NN
cord-322966-o65fo853	197	18	,	,	,
cord-322966-o65fo853	197	19	fatigue	fatigue	NN
cord-322966-o65fo853	197	20	,	,	,
cord-322966-o65fo853	197	21	depression	depression	NN
cord-322966-o65fo853	197	22	and	and	CC
cord-322966-o65fo853	197	23	disordered	disordered	JJ
cord-322966-o65fo853	197	24	sleep	sleep	NN
cord-322966-o65fo853	197	25	in	in	IN
cord-322966-o65fo853	197	26	chronic	chronic	JJ
cord-322966-o65fo853	197	27	post	post	JJ
cord-322966-o65fo853	197	28	-	-	JJ
cord-322966-o65fo853	197	29	SARS	SARS	NNP
cord-322966-o65fo853	197	30	syndrome	syndrome	NN
cord-322966-o65fo853	197	31	;	;	:
cord-322966-o65fo853	197	32	a	a	DT
cord-322966-o65fo853	197	33	case	case	NN
cord-322966-o65fo853	197	34	-	-	HYPH
cord-322966-o65fo853	197	35	controlled	control	VBN
cord-322966-o65fo853	197	36	study	study	NN
cord-322966-o65fo853	197	37	Altered	alter	VBD
cord-322966-o65fo853	197	38	lipid	lipid	NN
cord-322966-o65fo853	197	39	metabolism	metabolism	NN
cord-322966-o65fo853	197	40	in	in	IN
cord-322966-o65fo853	197	41	recovered	recover	VBN
cord-322966-o65fo853	197	42	SARS	SARS	NNP
cord-322966-o65fo853	197	43	patients	patient	NNS
cord-322966-o65fo853	197	44	twelve	twelve	CD
cord-322966-o65fo853	197	45	years	year	NNS
cord-322966-o65fo853	197	46	after	after	IN
cord-322966-o65fo853	197	47	infection	infection	NN
cord-322966-o65fo853	197	48	Long	long	JJ
cord-322966-o65fo853	197	49	term	term	NN
cord-322966-o65fo853	197	50	bone	bone	NN
cord-322966-o65fo853	197	51	and	and	CC
cord-322966-o65fo853	197	52	lung	lung	NN
cord-322966-o65fo853	197	53	consequences	consequence	NNS
cord-322966-o65fo853	197	54	associated	associate	VBN
cord-322966-o65fo853	197	55	with	with	IN
cord-322966-o65fo853	197	56	hospital	hospital	NN
cord-322966-o65fo853	197	57	-acquired	-acquired	JJ
cord-322966-o65fo853	197	58	severe	severe	JJ
cord-322966-o65fo853	197	59	acute	acute	JJ
cord-322966-o65fo853	197	60	respiratory	respiratory	JJ
cord-322966-o65fo853	197	61	syndrome	syndrome	NN
cord-322966-o65fo853	197	62	:	:	:
cord-322966-o65fo853	197	63	a	a	DT
cord-322966-o65fo853	197	64	15	15	CD
cord-322966-o65fo853	197	65	year	year	NN
cord-322966-o65fo853	197	66	follow	follow	NN
cord-322966-o65fo853	197	67	-	-	HYPH
cord-322966-o65fo853	197	68	up	up	NN
cord-322966-o65fo853	197	69	from	from	IN
cord-322966-o65fo853	197	70	a	a	DT
cord-322966-o65fo853	197	71	prospective	prospective	JJ
cord-322966-o65fo853	197	72	cohort	cohort	NN
cord-322966-o65fo853	197	73	study	study	NN
cord-322966-o65fo853	197	74	Autoantibodies	Autoantibodies	NNP
cord-322966-o65fo853	197	75	against	against	IN
cord-322966-o65fo853	197	76	human	human	JJ
cord-322966-o65fo853	197	77	epithelial	epithelial	JJ
cord-322966-o65fo853	197	78	cells	cell	NNS
cord-322966-o65fo853	197	79	and	and	CC
cord-322966-o65fo853	197	80	endothelial	endothelial	JJ
cord-322966-o65fo853	197	81	cells	cell	NNS
cord-322966-o65fo853	197	82	after	after	IN
cord-322966-o65fo853	197	83	severe	severe	JJ
cord-322966-o65fo853	197	84	acute	acute	JJ
cord-322966-o65fo853	197	85	respiratory	respiratory	JJ
cord-322966-o65fo853	197	86	syndrome	syndrome	NN
cord-322966-o65fo853	197	87	(	(	-LRB-
cord-322966-o65fo853	197	88	SARS)-associated	sars)-associated	CD
cord-322966-o65fo853	197	89	coronavirus	coronavirus	NN
cord-322966-o65fo853	197	90	infection	infection	NN
cord-322966-o65fo853	197	91	Are	be	VBP
cord-322966-o65fo853	197	92	vitamin	vitamin	NN
cord-322966-o65fo853	197	93	D	d	NN
cord-322966-o65fo853	197	94	receptor	receptor	NN
cord-322966-o65fo853	197	95	agonists	agonist	NNS
cord-322966-o65fo853	197	96	like	like	IN
cord-322966-o65fo853	197	97	angiotensin	angiotensin	NN
cord-322966-o65fo853	197	98	-	-	HYPH
cord-322966-o65fo853	197	99	converting	convert	VBG
cord-322966-o65fo853	197	100	enzyme	enzyme	NN
cord-322966-o65fo853	197	101	inhibitors	inhibitor	NNS
cord-322966-o65fo853	197	102	without	without	IN
cord-322966-o65fo853	197	103	side	side	NN
cord-322966-o65fo853	197	104	effects	effect	NNS
cord-322966-o65fo853	197	105	?	?	.
cord-322966-o65fo853	198	1	Evidence	evidence	NN
cord-322966-o65fo853	198	2	that	that	IN
cord-322966-o65fo853	198	3	vitamin	vitamin	NN
cord-322966-o65fo853	198	4	D	d	NN
cord-322966-o65fo853	198	5	supplementation	supplementation	NN
cord-322966-o65fo853	198	6	could	could	MD
cord-322966-o65fo853	198	7	reduce	reduce	VB
cord-322966-o65fo853	198	8	risk	risk	NN
cord-322966-o65fo853	198	9	of	of	IN
cord-322966-o65fo853	198	10	influenza	influenza	NN
cord-322966-o65fo853	198	11	and	and	CC
cord-322966-o65fo853	198	12	COVID-19	covid-19	JJ
cord-322966-o65fo853	198	13	infections	infection	NNS
cord-322966-o65fo853	198	14	and	and	CC
cord-322966-o65fo853	198	15	deaths	death	NNS
cord-322966-o65fo853	198	16	Hydroxychloroquine	Hydroxychloroquine	NNP
cord-322966-o65fo853	198	17	and	and	CC
cord-322966-o65fo853	198	18	azithromycin	azithromycin	NNP
cord-322966-o65fo853	198	19	as	as	IN
cord-322966-o65fo853	198	20	a	a	DT
cord-322966-o65fo853	198	21	treatment	treatment	NN
cord-322966-o65fo853	198	22	of	of	IN
cord-322966-o65fo853	198	23	COVID-19	covid-19	NN
cord-322966-o65fo853	198	24	;	;	:
cord-322966-o65fo853	198	25	results	result	NNS
cord-322966-o65fo853	198	26	of	of	IN
cord-322966-o65fo853	198	27	an	an	DT
cord-322966-o65fo853	198	28	open	open	JJ
cord-322966-o65fo853	198	29	label	label	NN
cord-322966-o65fo853	198	30	non	non	JJ
cord-322966-o65fo853	198	31	-	-	JJ
cord-322966-o65fo853	198	32	randomised	randomised	JJ
cord-322966-o65fo853	198	33	trial	trial	NN
cord-322966-o65fo853	198	34	Remdesivir	Remdesivir	NNP
cord-322966-o65fo853	198	35	in	in	IN
cord-322966-o65fo853	198	36	adults	adult	NNS
cord-322966-o65fo853	198	37	with	with	IN
cord-322966-o65fo853	198	38	severe	severe	JJ
cord-322966-o65fo853	198	39	COVID-19	covid-19	NN
cord-322966-o65fo853	198	40	:	:	:
cord-322966-o65fo853	199	1	a	a	DT
cord-322966-o65fo853	199	2	randomised	randomised	JJ
cord-322966-o65fo853	199	3	,	,	,
cord-322966-o65fo853	199	4	double	double	JJ
cord-322966-o65fo853	199	5	-	-	HYPH
cord-322966-o65fo853	199	6	blind	blind	JJ
cord-322966-o65fo853	199	7	,	,	,
cord-322966-o65fo853	199	8	placebo	placebo	NN
cord-322966-o65fo853	199	9	-	-	HYPH
cord-322966-o65fo853	199	10	controlled	control	VBN
cord-322966-o65fo853	199	11	,	,	,
cord-322966-o65fo853	199	12	multicentre	multicentre	NNP
cord-322966-o65fo853	199	13	trial	trial	NN
cord-322966-o65fo853	199	14	NIH	NIH	NNP
cord-322966-o65fo853	199	15	clinical	clinical	JJ
cord-322966-o65fo853	199	16	Trial	Trial	NNP
cord-322966-o65fo853	199	17	shows	show	VBZ
cord-322966-o65fo853	199	18	Remdesivir	Remdesivir	NNP
cord-322966-o65fo853	199	19	accelerates	accelerate	VBZ
cord-322966-o65fo853	199	20	recovery	recovery	NN
cord-322966-o65fo853	199	21	from	from	IN
cord-322966-o65fo853	199	22	advanced	advanced	JJ
cord-322966-o65fo853	199	23	COVID-19	COVID-19	NNP
cord-322966-o65fo853	199	24	Updated	update	VBN
cord-322966-o65fo853	199	25	approaches	approach	NNS
cord-322966-o65fo853	199	26	against	against	IN
cord-322966-o65fo853	199	27	SARS	SARS	NNP
cord-322966-o65fo853	199	28	-	-	HYPH
cord-322966-o65fo853	199	29	CoV-2	CoV-2	NNP
cord-322966-o65fo853	199	30	World	World	NNP
cord-322966-o65fo853	199	31	Health	Health	NNP
cord-322966-o65fo853	199	32	Organization	Organization	NNP
cord-322966-o65fo853	199	33	.	.	.
cord-322966-o65fo853	200	1	Overview	overview	NN
cord-322966-o65fo853	200	2	of	of	IN
cord-322966-o65fo853	200	3	the	the	DT
cord-322966-o65fo853	200	4	types	type	NNS
cord-322966-o65fo853	200	5	/	/	SYM
cord-322966-o65fo853	200	6	classes	class	NNS
cord-322966-o65fo853	200	7	of	of	IN
cord-322966-o65fo853	200	8	candidate	candidate	NN