id sid tid token lemma pos cord-302316-raf5rlkq 1 1 key key JJ cord-302316-raf5rlkq 2 1 : : : cord-302316-raf5rlkq 2 2 cord-302316-raf5rlkq cord-302316-raf5rlkq NNP cord-302316-raf5rlkq 2 3 authors author NNS cord-302316-raf5rlkq 2 4 : : : cord-302316-raf5rlkq 2 5 Brüssow Brüssow NNP cord-302316-raf5rlkq 2 6 , , , cord-302316-raf5rlkq 2 7 Harald Harald NNP cord-302316-raf5rlkq 2 8 title title NN cord-302316-raf5rlkq 2 9 : : : cord-302316-raf5rlkq 3 1 COVID‐19 COVID‐19 NNP cord-302316-raf5rlkq 3 2 : : : cord-302316-raf5rlkq 4 1 From from IN cord-302316-raf5rlkq 4 2 pathogenesis pathogenesis NN cord-302316-raf5rlkq 4 3 models model NNS cord-302316-raf5rlkq 4 4 to to IN cord-302316-raf5rlkq 4 5 the the DT cord-302316-raf5rlkq 4 6 first first JJ cord-302316-raf5rlkq 4 7 drug drug NN cord-302316-raf5rlkq 4 8 trials trial NNS cord-302316-raf5rlkq 4 9 date date NN cord-302316-raf5rlkq 4 10 : : : cord-302316-raf5rlkq 4 11 2020 2020 CD cord-302316-raf5rlkq 4 12 - - HYPH cord-302316-raf5rlkq 4 13 06 06 CD cord-302316-raf5rlkq 4 14 - - SYM cord-302316-raf5rlkq 4 15 23 23 CD cord-302316-raf5rlkq 4 16 journal journal NN cord-302316-raf5rlkq 4 17 : : : cord-302316-raf5rlkq 5 1 Microb Microb NNP cord-302316-raf5rlkq 5 2 Biotechnol Biotechnol NNP cord-302316-raf5rlkq 5 3 DOI DOI NNP cord-302316-raf5rlkq 5 4 : : : cord-302316-raf5rlkq 6 1 10.1111/1751 10.1111/1751 CD cord-302316-raf5rlkq 6 2 - - HYPH cord-302316-raf5rlkq 6 3 7915.13611 7915.13611 CD cord-302316-raf5rlkq 6 4 sha sha NNP cord-302316-raf5rlkq 6 5 : : : cord-302316-raf5rlkq 6 6 4ff99230184943cf2a9ccb2917e2dac74b330e25 4ff99230184943cf2a9ccb2917e2dac74b330e25 CD cord-302316-raf5rlkq 6 7 doc_id doc_id CD cord-302316-raf5rlkq 6 8 : : : cord-302316-raf5rlkq 6 9 302316 302316 CD cord-302316-raf5rlkq 6 10 cord_uid cord_uid NN cord-302316-raf5rlkq 6 11 : : : cord-302316-raf5rlkq 7 1 raf5rlkq raf5rlkq NNP cord-302316-raf5rlkq 8 1 The the DT cord-302316-raf5rlkq 8 2 number number NN cord-302316-raf5rlkq 8 3 of of IN cord-302316-raf5rlkq 8 4 people people NNS cord-302316-raf5rlkq 8 5 infected infect VBN cord-302316-raf5rlkq 8 6 with with IN cord-302316-raf5rlkq 8 7 SARS‐CoV‐2 SARS‐CoV‐2 NNP cord-302316-raf5rlkq 8 8 , , , cord-302316-raf5rlkq 8 9 and and CC cord-302316-raf5rlkq 8 10 sadly sadly RB cord-302316-raf5rlkq 8 11 dying die VBG cord-302316-raf5rlkq 8 12 from from IN cord-302316-raf5rlkq 8 13 COVID‐19 COVID‐19 NNP cord-302316-raf5rlkq 8 14 , , , cord-302316-raf5rlkq 8 15 has have VBZ cord-302316-raf5rlkq 8 16 exploded explode VBN cord-302316-raf5rlkq 8 17 , , , cord-302316-raf5rlkq 8 18 and and CC cord-302316-raf5rlkq 8 19 so so RB cord-302316-raf5rlkq 8 20 the the DT cord-302316-raf5rlkq 8 21 amount amount NN cord-302316-raf5rlkq 8 22 of of IN cord-302316-raf5rlkq 8 23 literature literature NN cord-302316-raf5rlkq 8 24 on on IN cord-302316-raf5rlkq 8 25 the the DT cord-302316-raf5rlkq 8 26 novel novel JJ cord-302316-raf5rlkq 8 27 coronavirus coronavirus NN cord-302316-raf5rlkq 8 28 and and CC cord-302316-raf5rlkq 8 29 the the DT cord-302316-raf5rlkq 8 30 disease disease NN cord-302316-raf5rlkq 8 31 it -PRON- PRP cord-302316-raf5rlkq 8 32 causes cause VBZ cord-302316-raf5rlkq 8 33 has have VBZ cord-302316-raf5rlkq 8 34 increased increase VBN cord-302316-raf5rlkq 8 35 proportionately proportionately RB cord-302316-raf5rlkq 8 36 . . . cord-302316-raf5rlkq 9 1 The the DT cord-302316-raf5rlkq 9 2 case case NN cord-302316-raf5rlkq 9 3 numbers number NNS cord-302316-raf5rlkq 9 4 in in IN cord-302316-raf5rlkq 9 5 some some DT cord-302316-raf5rlkq 9 6 countries country NNS cord-302316-raf5rlkq 9 7 are be VBP cord-302316-raf5rlkq 9 8 beyond beyond IN cord-302316-raf5rlkq 9 9 the the DT cord-302316-raf5rlkq 9 10 epidemic epidemic NN cord-302316-raf5rlkq 9 11 peak peak NN cord-302316-raf5rlkq 9 12 , , , cord-302316-raf5rlkq 9 13 but but CC cord-302316-raf5rlkq 9 14 the the DT cord-302316-raf5rlkq 9 15 uncertainty uncertainty NN cord-302316-raf5rlkq 9 16 about about IN cord-302316-raf5rlkq 9 17 a a DT cord-302316-raf5rlkq 9 18 second second JJ cord-302316-raf5rlkq 9 19 wave wave NN cord-302316-raf5rlkq 9 20 keeps keep VBZ cord-302316-raf5rlkq 9 21 politicians politician NNS cord-302316-raf5rlkq 9 22 and and CC cord-302316-raf5rlkq 9 23 societies society NNS cord-302316-raf5rlkq 9 24 under under IN cord-302316-raf5rlkq 9 25 pressure pressure NN cord-302316-raf5rlkq 9 26 . . . cord-302316-raf5rlkq 10 1 Appropriate appropriate JJ cord-302316-raf5rlkq 10 2 decision‐making decision‐making NN cord-302316-raf5rlkq 10 3 and and CC cord-302316-raf5rlkq 10 4 winning win VBG cord-302316-raf5rlkq 10 5 support support NN cord-302316-raf5rlkq 10 6 from from IN cord-302316-raf5rlkq 10 7 the the DT cord-302316-raf5rlkq 10 8 population population NN cord-302316-raf5rlkq 10 9 depends depend VBZ cord-302316-raf5rlkq 10 10 on on IN cord-302316-raf5rlkq 10 11 precise precise JJ cord-302316-raf5rlkq 10 12 scientific scientific JJ cord-302316-raf5rlkq 10 13 information information NN cord-302316-raf5rlkq 10 14 rather rather RB cord-302316-raf5rlkq 10 15 than than IN cord-302316-raf5rlkq 10 16 leaving leave VBG cord-302316-raf5rlkq 10 17 the the DT cord-302316-raf5rlkq 10 18 field field NN cord-302316-raf5rlkq 10 19 to to IN cord-302316-raf5rlkq 10 20 scaremongers scaremonger NNS cord-302316-raf5rlkq 10 21 of of IN cord-302316-raf5rlkq 10 22 all all DT cord-302316-raf5rlkq 10 23 proveniences provenience NNS cord-302316-raf5rlkq 10 24 . . . cord-302316-raf5rlkq 11 1 This this DT cord-302316-raf5rlkq 11 2 mini‐review mini‐review NNP cord-302316-raf5rlkq 11 3 is be VBZ cord-302316-raf5rlkq 11 4 an an DT cord-302316-raf5rlkq 11 5 update update NN cord-302316-raf5rlkq 11 6 of of IN cord-302316-raf5rlkq 11 7 earlier early JJR cord-302316-raf5rlkq 11 8 reports report NNS cord-302316-raf5rlkq 12 1 ( ( -LRB- cord-302316-raf5rlkq 12 2 Brüssow Brüssow NNP cord-302316-raf5rlkq 12 3 , , , cord-302316-raf5rlkq 12 4 Microb Microb NNP cord-302316-raf5rlkq 12 5 Biotechnol Biotechnol NNP cord-302316-raf5rlkq 12 6 2020a;13:607 2020a;13:607 CD cord-302316-raf5rlkq 12 7 ; ; : cord-302316-raf5rlkq 12 8 Brüssow Brüssow NNP cord-302316-raf5rlkq 12 9 , , , cord-302316-raf5rlkq 12 10 Microb Microb NNP cord-302316-raf5rlkq 12 11 Biotechnol Biotechnol NNP cord-302316-raf5rlkq 12 12 2020b 2020b NNS cord-302316-raf5rlkq 12 13 ; ; : cord-302316-raf5rlkq 12 14 https://doi.org/10.1111/1751-7915.13592 https://doi.org/10.1111/1751-7915.13592 ADD cord-302316-raf5rlkq 12 15 ) ) -RRB- cord-302316-raf5rlkq 12 16 . . . cord-302316-raf5rlkq 13 1 The the DT cord-302316-raf5rlkq 13 2 number number NN cord-302316-raf5rlkq 13 3 of of IN cord-302316-raf5rlkq 13 4 people people NNS cord-302316-raf5rlkq 13 5 infected infect VBN cord-302316-raf5rlkq 13 6 with with IN cord-302316-raf5rlkq 13 7 SARS SARS NNP cord-302316-raf5rlkq 13 8 - - HYPH cord-302316-raf5rlkq 13 9 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 13 10 , , , cord-302316-raf5rlkq 13 11 and and CC cord-302316-raf5rlkq 13 12 sadly sadly RB cord-302316-raf5rlkq 13 13 dying die VBG cord-302316-raf5rlkq 13 14 from from IN cord-302316-raf5rlkq 13 15 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 13 16 , , , cord-302316-raf5rlkq 13 17 has have VBZ cord-302316-raf5rlkq 13 18 exploded explode VBN cord-302316-raf5rlkq 13 19 , , , cord-302316-raf5rlkq 13 20 and and CC cord-302316-raf5rlkq 13 21 so so RB cord-302316-raf5rlkq 13 22 the the DT cord-302316-raf5rlkq 13 23 amount amount NN cord-302316-raf5rlkq 13 24 of of IN cord-302316-raf5rlkq 13 25 literature literature NN cord-302316-raf5rlkq 13 26 on on IN cord-302316-raf5rlkq 13 27 the the DT cord-302316-raf5rlkq 13 28 novel novel JJ cord-302316-raf5rlkq 13 29 coronavirus coronavirus NN cord-302316-raf5rlkq 13 30 and and CC cord-302316-raf5rlkq 13 31 the the DT cord-302316-raf5rlkq 13 32 disease disease NN cord-302316-raf5rlkq 13 33 it -PRON- PRP cord-302316-raf5rlkq 13 34 causes cause VBZ cord-302316-raf5rlkq 13 35 has have VBZ cord-302316-raf5rlkq 13 36 increased increase VBN cord-302316-raf5rlkq 13 37 proportionately proportionately RB cord-302316-raf5rlkq 13 38 . . . cord-302316-raf5rlkq 14 1 The the DT cord-302316-raf5rlkq 14 2 case case NN cord-302316-raf5rlkq 14 3 numbers number NNS cord-302316-raf5rlkq 14 4 in in IN cord-302316-raf5rlkq 14 5 some some DT cord-302316-raf5rlkq 14 6 countries country NNS cord-302316-raf5rlkq 14 7 are be VBP cord-302316-raf5rlkq 14 8 beyond beyond IN cord-302316-raf5rlkq 14 9 the the DT cord-302316-raf5rlkq 14 10 epidemic epidemic NN cord-302316-raf5rlkq 14 11 peak peak NN cord-302316-raf5rlkq 14 12 , , , cord-302316-raf5rlkq 14 13 but but CC cord-302316-raf5rlkq 14 14 the the DT cord-302316-raf5rlkq 14 15 uncertainty uncertainty NN cord-302316-raf5rlkq 14 16 about about IN cord-302316-raf5rlkq 14 17 a a DT cord-302316-raf5rlkq 14 18 second second JJ cord-302316-raf5rlkq 14 19 wave wave NN cord-302316-raf5rlkq 14 20 keeps keep VBZ cord-302316-raf5rlkq 14 21 politicians politician NNS cord-302316-raf5rlkq 14 22 and and CC cord-302316-raf5rlkq 14 23 societies society NNS cord-302316-raf5rlkq 14 24 under under IN cord-302316-raf5rlkq 14 25 pressure pressure NN cord-302316-raf5rlkq 14 26 . . . cord-302316-raf5rlkq 15 1 Appropriate appropriate JJ cord-302316-raf5rlkq 15 2 decision decision NN cord-302316-raf5rlkq 15 3 - - HYPH cord-302316-raf5rlkq 15 4 making making NN cord-302316-raf5rlkq 15 5 and and CC cord-302316-raf5rlkq 15 6 winning win VBG cord-302316-raf5rlkq 15 7 support support NN cord-302316-raf5rlkq 15 8 from from IN cord-302316-raf5rlkq 15 9 the the DT cord-302316-raf5rlkq 15 10 population population NN cord-302316-raf5rlkq 15 11 depends depend VBZ cord-302316-raf5rlkq 15 12 on on IN cord-302316-raf5rlkq 15 13 precise precise JJ cord-302316-raf5rlkq 15 14 scientific scientific JJ cord-302316-raf5rlkq 15 15 information information NN cord-302316-raf5rlkq 15 16 rather rather RB cord-302316-raf5rlkq 15 17 than than IN cord-302316-raf5rlkq 15 18 leaving leave VBG cord-302316-raf5rlkq 15 19 the the DT cord-302316-raf5rlkq 15 20 field field NN cord-302316-raf5rlkq 15 21 to to IN cord-302316-raf5rlkq 15 22 scaremongers scaremonger NNS cord-302316-raf5rlkq 15 23 of of IN cord-302316-raf5rlkq 15 24 all all DT cord-302316-raf5rlkq 15 25 proveniences provenience NNS cord-302316-raf5rlkq 15 26 . . . cord-302316-raf5rlkq 16 1 This this DT cord-302316-raf5rlkq 16 2 mini mini JJ cord-302316-raf5rlkq 16 3 - - NN cord-302316-raf5rlkq 16 4 review review NN cord-302316-raf5rlkq 16 5 is be VBZ cord-302316-raf5rlkq 16 6 an an DT cord-302316-raf5rlkq 16 7 update update NN cord-302316-raf5rlkq 16 8 of of IN cord-302316-raf5rlkq 16 9 earlier early JJR cord-302316-raf5rlkq 16 10 reports report NNS cord-302316-raf5rlkq 16 11 ( ( -LRB- cord-302316-raf5rlkq 16 12 Br€ Br€ NNP cord-302316-raf5rlkq 16 13 ussow ussow NNP cord-302316-raf5rlkq 16 14 , , , cord-302316-raf5rlkq 16 15 Microb Microb NNP cord-302316-raf5rlkq 16 16 Biotechnol Biotechnol NNP cord-302316-raf5rlkq 16 17 2020a 2020a NNS cord-302316-raf5rlkq 16 18 ; ; : cord-302316-raf5rlkq 16 19 13:607 13:607 CD cord-302316-raf5rlkq 16 20 ; ; : cord-302316-raf5rlkq 16 21 Br€ Br€ NNP cord-302316-raf5rlkq 16 22 ussow ussow NN cord-302316-raf5rlkq 16 23 , , , cord-302316-raf5rlkq 16 24 Microb Microb NNP cord-302316-raf5rlkq 16 25 Biotechnol Biotechnol NNP cord-302316-raf5rlkq 16 26 2020b 2020b NNS cord-302316-raf5rlkq 16 27 ; ; : cord-302316-raf5rlkq 16 28 https://doi.org/10.1111 https://doi.org/10.1111 NN cord-302316-raf5rlkq 16 29 /1751 /1751 NNP cord-302316-raf5rlkq 16 30 ) ) -RRB- cord-302316-raf5rlkq 16 31 . . . cord-302316-raf5rlkq 17 1 Autopsies autopsy NNS cord-302316-raf5rlkq 17 2 can can MD cord-302316-raf5rlkq 17 3 provide provide VB cord-302316-raf5rlkq 17 4 valuable valuable JJ cord-302316-raf5rlkq 17 5 insight insight NN cord-302316-raf5rlkq 17 6 into into IN cord-302316-raf5rlkq 17 7 new new JJ cord-302316-raf5rlkq 17 8 diseases disease NNS cord-302316-raf5rlkq 17 9 which which WDT cord-302316-raf5rlkq 17 10 complement complement VBP cord-302316-raf5rlkq 17 11 or or CC cord-302316-raf5rlkq 17 12 correct correct JJ cord-302316-raf5rlkq 17 13 observations observation NNS cord-302316-raf5rlkq 17 14 made make VBN cord-302316-raf5rlkq 17 15 by by IN cord-302316-raf5rlkq 17 16 clinicians clinician NNS cord-302316-raf5rlkq 17 17 . . . cord-302316-raf5rlkq 18 1 Surprisingly surprisingly RB cord-302316-raf5rlkq 18 2 , , , cord-302316-raf5rlkq 18 3 it -PRON- PRP cord-302316-raf5rlkq 18 4 took take VBD cord-302316-raf5rlkq 18 5 a a DT cord-302316-raf5rlkq 18 6 while while NN cord-302316-raf5rlkq 18 7 until until IN cord-302316-raf5rlkq 18 8 the the DT cord-302316-raf5rlkq 18 9 first first JJ cord-302316-raf5rlkq 18 10 pathology pathology NN cord-302316-raf5rlkq 18 11 reports report NNS cord-302316-raf5rlkq 18 12 were be VBD cord-302316-raf5rlkq 18 13 published publish VBN cord-302316-raf5rlkq 18 14 for for IN cord-302316-raf5rlkq 18 15 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 18 16 patients patient NNS cord-302316-raf5rlkq 18 17 . . . cord-302316-raf5rlkq 19 1 This this DT cord-302316-raf5rlkq 19 2 delay delay NN cord-302316-raf5rlkq 19 3 is be VBZ cord-302316-raf5rlkq 19 4 explained explain VBN cord-302316-raf5rlkq 19 5 by by IN cord-302316-raf5rlkq 19 6 the the DT cord-302316-raf5rlkq 19 7 emergency emergency NN cord-302316-raf5rlkq 19 8 situation situation NN cord-302316-raf5rlkq 19 9 of of IN cord-302316-raf5rlkq 19 10 a a DT cord-302316-raf5rlkq 19 11 pandemic pandemic NN cord-302316-raf5rlkq 19 12 , , , cord-302316-raf5rlkq 19 13 the the DT cord-302316-raf5rlkq 19 14 limited limited JJ cord-302316-raf5rlkq 19 15 number number NN cord-302316-raf5rlkq 19 16 of of IN cord-302316-raf5rlkq 19 17 complete complete JJ cord-302316-raf5rlkq 19 18 sections section NNS cord-302316-raf5rlkq 19 19 that that WDT cord-302316-raf5rlkq 19 20 can can MD cord-302316-raf5rlkq 19 21 be be VB cord-302316-raf5rlkq 19 22 conducted conduct VBN cord-302316-raf5rlkq 19 23 by by IN cord-302316-raf5rlkq 19 24 a a DT cord-302316-raf5rlkq 19 25 pathology pathology NN cord-302316-raf5rlkq 19 26 institute institute NN cord-302316-raf5rlkq 19 27 , , , cord-302316-raf5rlkq 19 28 biosafety biosafety NN cord-302316-raf5rlkq 19 29 issues issue NNS cord-302316-raf5rlkq 19 30 and and CC cord-302316-raf5rlkq 19 31 a a DT cord-302316-raf5rlkq 19 32 decreasing decrease VBG cord-302316-raf5rlkq 19 33 role role NN cord-302316-raf5rlkq 19 34 of of IN cord-302316-raf5rlkq 19 35 pathology pathology NN cord-302316-raf5rlkq 19 36 in in IN cord-302316-raf5rlkq 19 37 medical medical JJ cord-302316-raf5rlkq 19 38 research research NN cord-302316-raf5rlkq 19 39 . . . cord-302316-raf5rlkq 20 1 In in IN cord-302316-raf5rlkq 20 2 a a DT cord-302316-raf5rlkq 20 3 US US NNP cord-302316-raf5rlkq 20 4 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 20 5 patient patient NN cord-302316-raf5rlkq 20 6 , , , cord-302316-raf5rlkq 20 7 the the DT cord-302316-raf5rlkq 20 8 lungs lung NNS cord-302316-raf5rlkq 20 9 were be VBD cord-302316-raf5rlkq 20 10 of of IN cord-302316-raf5rlkq 20 11 firm firm JJ cord-302316-raf5rlkq 20 12 consistency consistency NN cord-302316-raf5rlkq 20 13 and and CC cord-302316-raf5rlkq 20 14 heavy heavy JJ cord-302316-raf5rlkq 20 15 with with IN cord-302316-raf5rlkq 20 16 oedema oedema NN cord-302316-raf5rlkq 20 17 . . . cord-302316-raf5rlkq 21 1 Upon upon IN cord-302316-raf5rlkq 21 2 histological histological JJ cord-302316-raf5rlkq 21 3 analysis analysis NN cord-302316-raf5rlkq 21 4 , , , cord-302316-raf5rlkq 21 5 diffuse diffuse VB cord-302316-raf5rlkq 21 6 alveolar alveolar NN cord-302316-raf5rlkq 21 7 damage damage NN cord-302316-raf5rlkq 21 8 ( ( -LRB- cord-302316-raf5rlkq 21 9 DAD DAD NNP cord-302316-raf5rlkq 21 10 ) ) -RRB- cord-302316-raf5rlkq 21 11 was be VBD cord-302316-raf5rlkq 21 12 diagnosed diagnose VBN cord-302316-raf5rlkq 21 13 . . . cord-302316-raf5rlkq 22 1 Thrombi Thrombi NNP cord-302316-raf5rlkq 22 2 were be VBD cord-302316-raf5rlkq 22 3 seen see VBN cord-302316-raf5rlkq 22 4 in in IN cord-302316-raf5rlkq 22 5 small small JJ cord-302316-raf5rlkq 22 6 lung lung NN cord-302316-raf5rlkq 22 7 arteries artery NNS cord-302316-raf5rlkq 22 8 , , , cord-302316-raf5rlkq 22 9 and and CC cord-302316-raf5rlkq 22 10 there there EX cord-302316-raf5rlkq 22 11 was be VBD cord-302316-raf5rlkq 22 12 congestion congestion NN cord-302316-raf5rlkq 22 13 in in IN cord-302316-raf5rlkq 22 14 capillaries capillary NNS cord-302316-raf5rlkq 22 15 . . . cord-302316-raf5rlkq 23 1 Alveoli Alveoli NNP cord-302316-raf5rlkq 23 2 showed show VBD cord-302316-raf5rlkq 23 3 hyaline hyaline JJ cord-302316-raf5rlkq 23 4 membrane membrane NN cord-302316-raf5rlkq 23 5 formation formation NN cord-302316-raf5rlkq 23 6 . . . cord-302316-raf5rlkq 24 1 The the DT cord-302316-raf5rlkq 24 2 lung lung NN cord-302316-raf5rlkq 24 3 tissue tissue NN cord-302316-raf5rlkq 24 4 displayed display VBD cord-302316-raf5rlkq 24 5 chronic chronic JJ cord-302316-raf5rlkq 24 6 inflammation inflammation NN cord-302316-raf5rlkq 24 7 with with IN cord-302316-raf5rlkq 24 8 invasion invasion NN cord-302316-raf5rlkq 24 9 of of IN cord-302316-raf5rlkq 24 10 T t NN cord-302316-raf5rlkq 24 11 lymphocytes lymphocyte NNS cord-302316-raf5rlkq 24 12 . . . cord-302316-raf5rlkq 25 1 The the DT cord-302316-raf5rlkq 25 2 patient patient NN cord-302316-raf5rlkq 25 3 died die VBD cord-302316-raf5rlkq 25 4 of of IN cord-302316-raf5rlkq 25 5 cardiac cardiac JJ cord-302316-raf5rlkq 25 6 arrest arrest NN cord-302316-raf5rlkq 25 7 ( ( -LRB- cord-302316-raf5rlkq 25 8 Barton Barton NNP cord-302316-raf5rlkq 25 9 et et NNP cord-302316-raf5rlkq 25 10 al al NNP cord-302316-raf5rlkq 25 11 . . NNP cord-302316-raf5rlkq 25 12 , , , cord-302316-raf5rlkq 25 13 2020 2020 CD cord-302316-raf5rlkq 25 14 ) ) -RRB- cord-302316-raf5rlkq 25 15 . . . cord-302316-raf5rlkq 26 1 A a DT cord-302316-raf5rlkq 26 2 Chinese chinese JJ cord-302316-raf5rlkq 26 3 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 26 4 patient patient NN cord-302316-raf5rlkq 26 5 showed show VBD cord-302316-raf5rlkq 26 6 , , , cord-302316-raf5rlkq 26 7 likewise likewise RB cord-302316-raf5rlkq 26 8 : : : cord-302316-raf5rlkq 26 9 DAD DAD NNP cord-302316-raf5rlkq 26 10 , , , cord-302316-raf5rlkq 26 11 hyaline hyaline JJ cord-302316-raf5rlkq 26 12 membranes membrane NNS cord-302316-raf5rlkq 26 13 and and CC cord-302316-raf5rlkq 26 14 pulmonary pulmonary JJ cord-302316-raf5rlkq 26 15 oedema oedema NN cord-302316-raf5rlkq 26 16 together together RB cord-302316-raf5rlkq 26 17 with with IN cord-302316-raf5rlkq 26 18 inflammatory inflammatory JJ cord-302316-raf5rlkq 26 19 infiltrates infiltrate NNS cord-302316-raf5rlkq 26 20 and and CC cord-302316-raf5rlkq 26 21 multinuclear multinuclear NN cord-302316-raf5rlkq 26 22 syncytia syncytia NN cord-302316-raf5rlkq 26 23 , , , cord-302316-raf5rlkq 26 24 typical typical JJ cord-302316-raf5rlkq 26 25 cytopathic cytopathic JJ cord-302316-raf5rlkq 26 26 effects effect NNS cord-302316-raf5rlkq 26 27 of of IN cord-302316-raf5rlkq 26 28 coronaviruses coronaviruse NNS cord-302316-raf5rlkq 26 29 . . . cord-302316-raf5rlkq 27 1 The the DT cord-302316-raf5rlkq 27 2 patient patient NN cord-302316-raf5rlkq 27 3 showed show VBD cord-302316-raf5rlkq 27 4 overactive overactive JJ cord-302316-raf5rlkq 27 5 T t NN cord-302316-raf5rlkq 27 6 cells cell NNS cord-302316-raf5rlkq 27 7 with with IN cord-302316-raf5rlkq 27 8 a a DT cord-302316-raf5rlkq 27 9 marked marked JJ cord-302316-raf5rlkq 27 10 increase increase NN cord-302316-raf5rlkq 27 11 in in IN cord-302316-raf5rlkq 27 12 Th17 Th17 NNP cord-302316-raf5rlkq 27 13 cells cell NNS cord-302316-raf5rlkq 27 14 and and CC cord-302316-raf5rlkq 27 15 high high JJ cord-302316-raf5rlkq 27 16 cytotoxicity cytotoxicity NN cord-302316-raf5rlkq 27 17 of of IN cord-302316-raf5rlkq 27 18 CD8 CD8 NNP cord-302316-raf5rlkq 27 19 T T NNP cord-302316-raf5rlkq 27 20 cells cell NNS cord-302316-raf5rlkq 27 21 , , , cord-302316-raf5rlkq 27 22 potentially potentially RB cord-302316-raf5rlkq 27 23 explaining explain VBG cord-302316-raf5rlkq 27 24 the the DT cord-302316-raf5rlkq 27 25 severe severe JJ cord-302316-raf5rlkq 27 26 immune immune JJ cord-302316-raf5rlkq 27 27 injury injury NN cord-302316-raf5rlkq 27 28 seen see VBN cord-302316-raf5rlkq 27 29 in in IN cord-302316-raf5rlkq 27 30 the the DT cord-302316-raf5rlkq 27 31 lung lung NN cord-302316-raf5rlkq 27 32 of of IN cord-302316-raf5rlkq 27 33 this this DT cord-302316-raf5rlkq 27 34 patient patient NN cord-302316-raf5rlkq 27 35 . . . cord-302316-raf5rlkq 28 1 The the DT cord-302316-raf5rlkq 28 2 first first JJ cord-302316-raf5rlkq 28 3 larger large JJR cord-302316-raf5rlkq 28 4 series series NN cord-302316-raf5rlkq 28 5 of of IN cord-302316-raf5rlkq 28 6 autopsies autopsy NNS cord-302316-raf5rlkq 28 7 was be VBD cord-302316-raf5rlkq 28 8 published publish VBN cord-302316-raf5rlkq 28 9 for for IN cord-302316-raf5rlkq 28 10 12 12 CD cord-302316-raf5rlkq 28 11 German german JJ cord-302316-raf5rlkq 28 12 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 28 13 patients patient NNS cord-302316-raf5rlkq 28 14 . . . cord-302316-raf5rlkq 29 1 Their -PRON- PRP$ cord-302316-raf5rlkq 29 2 average average JJ cord-302316-raf5rlkq 29 3 age age NN cord-302316-raf5rlkq 29 4 was be VBD cord-302316-raf5rlkq 29 5 73 73 CD cord-302316-raf5rlkq 29 6 years year NNS cord-302316-raf5rlkq 29 7 , , , cord-302316-raf5rlkq 29 8 and and CC cord-302316-raf5rlkq 29 9 most most JJS cord-302316-raf5rlkq 29 10 were be VBD cord-302316-raf5rlkq 29 11 obese obese JJ cord-302316-raf5rlkq 29 12 . . . cord-302316-raf5rlkq 30 1 Deep deep JJ cord-302316-raf5rlkq 30 2 venous venous JJ cord-302316-raf5rlkq 30 3 thrombosis thrombosis NN cord-302316-raf5rlkq 30 4 was be VBD cord-302316-raf5rlkq 30 5 found find VBN cord-302316-raf5rlkq 30 6 in in IN cord-302316-raf5rlkq 30 7 7 7 CD cord-302316-raf5rlkq 30 8 patients patient NNS cord-302316-raf5rlkq 30 9 that that WDT cord-302316-raf5rlkq 30 10 had have VBD cord-302316-raf5rlkq 30 11 not not RB cord-302316-raf5rlkq 30 12 been be VBN cord-302316-raf5rlkq 30 13 suspected suspect VBN cord-302316-raf5rlkq 30 14 before before IN cord-302316-raf5rlkq 30 15 death death NN cord-302316-raf5rlkq 30 16 . . . cord-302316-raf5rlkq 31 1 Pulmonary pulmonary JJ cord-302316-raf5rlkq 31 2 embolism embolism NN cord-302316-raf5rlkq 31 3 was be VBD cord-302316-raf5rlkq 31 4 the the DT cord-302316-raf5rlkq 31 5 cause cause NN cord-302316-raf5rlkq 31 6 of of IN cord-302316-raf5rlkq 31 7 death death NN cord-302316-raf5rlkq 31 8 in in IN cord-302316-raf5rlkq 31 9 4 4 CD cord-302316-raf5rlkq 31 10 patients patient NNS cord-302316-raf5rlkq 31 11 . . . cord-302316-raf5rlkq 32 1 The the DT cord-302316-raf5rlkq 32 2 thrombi thrombi NN cord-302316-raf5rlkq 32 3 were be VBD cord-302316-raf5rlkq 32 4 derived derive VBN cord-302316-raf5rlkq 32 5 from from IN cord-302316-raf5rlkq 32 6 deep deep JJ cord-302316-raf5rlkq 32 7 veins vein NNS cord-302316-raf5rlkq 32 8 in in IN cord-302316-raf5rlkq 32 9 the the DT cord-302316-raf5rlkq 32 10 lower low JJR cord-302316-raf5rlkq 32 11 extremities extremity NNS cord-302316-raf5rlkq 32 12 . . . cord-302316-raf5rlkq 33 1 In in IN cord-302316-raf5rlkq 33 2 all all DT cord-302316-raf5rlkq 33 3 cases case NNS cord-302316-raf5rlkq 33 4 , , , cord-302316-raf5rlkq 33 5 the the DT cord-302316-raf5rlkq 33 6 cause cause NN cord-302316-raf5rlkq 33 7 of of IN cord-302316-raf5rlkq 33 8 death death NN cord-302316-raf5rlkq 33 9 was be VBD cord-302316-raf5rlkq 33 10 found find VBN cord-302316-raf5rlkq 33 11 in in IN cord-302316-raf5rlkq 33 12 the the DT cord-302316-raf5rlkq 33 13 lungs lung NNS cord-302316-raf5rlkq 33 14 which which WDT cord-302316-raf5rlkq 33 15 were be VBD cord-302316-raf5rlkq 33 16 congested congested JJ cord-302316-raf5rlkq 33 17 and and CC cord-302316-raf5rlkq 33 18 heavy heavy JJ cord-302316-raf5rlkq 33 19 , , , cord-302316-raf5rlkq 33 20 weighing weigh VBG cord-302316-raf5rlkq 33 21 2 2 CD cord-302316-raf5rlkq 33 22 kg kg NNS cord-302316-raf5rlkq 33 23 instead instead RB cord-302316-raf5rlkq 33 24 of of IN cord-302316-raf5rlkq 33 25 800 800 CD cord-302316-raf5rlkq 33 26 g. g. NNP cord-302316-raf5rlkq 34 1 At at IN cord-302316-raf5rlkq 34 2 a a DT cord-302316-raf5rlkq 34 3 histological histological JJ cord-302316-raf5rlkq 34 4 level level NN cord-302316-raf5rlkq 34 5 , , , cord-302316-raf5rlkq 34 6 diffuse diffuse VB cord-302316-raf5rlkq 34 7 alveolar alveolar JJ cord-302316-raf5rlkq 34 8 damage damage NN cord-302316-raf5rlkq 34 9 was be VBD cord-302316-raf5rlkq 34 10 seen see VBN cord-302316-raf5rlkq 34 11 in in IN cord-302316-raf5rlkq 34 12 8 8 CD cord-302316-raf5rlkq 34 13 patients patient NNS cord-302316-raf5rlkq 34 14 . . . cord-302316-raf5rlkq 35 1 Viral Viral NNP cord-302316-raf5rlkq 35 2 RNA RNA NNP cord-302316-raf5rlkq 35 3 was be VBD cord-302316-raf5rlkq 35 4 detected detect VBN cord-302316-raf5rlkq 35 5 with with IN cord-302316-raf5rlkq 35 6 high high JJ cord-302316-raf5rlkq 35 7 titres titre NNS cord-302316-raf5rlkq 35 8 in in IN cord-302316-raf5rlkq 35 9 liver liver NN cord-302316-raf5rlkq 35 10 , , , cord-302316-raf5rlkq 35 11 heart heart NN cord-302316-raf5rlkq 35 12 and and CC cord-302316-raf5rlkq 35 13 kidney kidney NN cord-302316-raf5rlkq 35 14 . . . cord-302316-raf5rlkq 36 1 Clinical clinical JJ cord-302316-raf5rlkq 36 2 chemistry chemistry NN cord-302316-raf5rlkq 36 3 showed show VBD cord-302316-raf5rlkq 36 4 increased increase VBN cord-302316-raf5rlkq 36 5 levels level NNS cord-302316-raf5rlkq 36 6 of of IN cord-302316-raf5rlkq 36 7 lactate lactate NN cord-302316-raf5rlkq 36 8 dehydrogenase dehydrogenase NN cord-302316-raf5rlkq 36 9 , , , cord-302316-raf5rlkq 36 10 D d NN cord-302316-raf5rlkq 36 11 - - HYPH cord-302316-raf5rlkq 36 12 dimer dimer NN cord-302316-raf5rlkq 36 13 and and CC cord-302316-raf5rlkq 36 14 C c NN cord-302316-raf5rlkq 36 15 - - HYPH cord-302316-raf5rlkq 36 16 reactive reactive JJ cord-302316-raf5rlkq 36 17 protein protein NN cord-302316-raf5rlkq 36 18 , , , cord-302316-raf5rlkq 36 19 suggesting suggest VBG cord-302316-raf5rlkq 36 20 coagulopathy coagulopathy NN cord-302316-raf5rlkq 36 21 as as IN cord-302316-raf5rlkq 36 22 a a DT cord-302316-raf5rlkq 36 23 complication complication NN cord-302316-raf5rlkq 36 24 in in IN cord-302316-raf5rlkq 36 25 these these DT cord-302316-raf5rlkq 36 26 severe severe JJ cord-302316-raf5rlkq 36 27 COVID-19 covid-19 JJ cord-302316-raf5rlkq 36 28 cases case NNS cord-302316-raf5rlkq 36 29 ( ( -LRB- cord-302316-raf5rlkq 36 30 Wichmann Wichmann NNP cord-302316-raf5rlkq 36 31 et et NNP cord-302316-raf5rlkq 36 32 al al NNP cord-302316-raf5rlkq 36 33 . . NNP cord-302316-raf5rlkq 36 34 , , , cord-302316-raf5rlkq 36 35 2020 2020 CD cord-302316-raf5rlkq 36 36 ) ) -RRB- cord-302316-raf5rlkq 36 37 . . . cord-302316-raf5rlkq 37 1 Interestingly interestingly RB cord-302316-raf5rlkq 37 2 , , , cord-302316-raf5rlkq 37 3 obesity obesity NN cord-302316-raf5rlkq 37 4 is be VBZ cord-302316-raf5rlkq 37 5 increasingly increasingly RB cord-302316-raf5rlkq 37 6 seen see VBN cord-302316-raf5rlkq 37 7 as as IN cord-302316-raf5rlkq 37 8 a a DT cord-302316-raf5rlkq 37 9 risk risk NN cord-302316-raf5rlkq 37 10 factor factor NN cord-302316-raf5rlkq 37 11 for for IN cord-302316-raf5rlkq 37 12 severe severe JJ cord-302316-raf5rlkq 37 13 disease disease NN cord-302316-raf5rlkq 37 14 . . . cord-302316-raf5rlkq 38 1 In in IN cord-302316-raf5rlkq 38 2 a a DT cord-302316-raf5rlkq 38 3 retrospective retrospective JJ cord-302316-raf5rlkq 38 4 study study NN cord-302316-raf5rlkq 38 5 with with IN cord-302316-raf5rlkq 38 6 3615 3615 CD cord-302316-raf5rlkq 38 7 Covid-19 covid-19 NN cord-302316-raf5rlkq 38 8 patients patient NNS cord-302316-raf5rlkq 38 9 from from IN cord-302316-raf5rlkq 38 10 New New NNP cord-302316-raf5rlkq 38 11 York York NNP cord-302316-raf5rlkq 38 12 City City NNP cord-302316-raf5rlkq 38 13 , , , cord-302316-raf5rlkq 38 14 clinicians clinician NNS cord-302316-raf5rlkq 38 15 had have VBD cord-302316-raf5rlkq 38 16 described describe VBN cord-302316-raf5rlkq 38 17 obesity obesity NN cord-302316-raf5rlkq 38 18 as as IN cord-302316-raf5rlkq 38 19 a a DT cord-302316-raf5rlkq 38 20 risk risk NN cord-302316-raf5rlkq 38 21 factor factor NN cord-302316-raf5rlkq 38 22 for for IN cord-302316-raf5rlkq 38 23 intensive intensive JJ cord-302316-raf5rlkq 38 24 care care NN cord-302316-raf5rlkq 38 25 need need NN cord-302316-raf5rlkq 38 26 ( ( -LRB- cord-302316-raf5rlkq 38 27 OR or CC cord-302316-raf5rlkq 38 28 1.8 1.8 CD cord-302316-raf5rlkq 38 29 to to IN cord-302316-raf5rlkq 38 30 3.6 3.6 CD cord-302316-raf5rlkq 38 31 ) ) -RRB- cord-302316-raf5rlkq 38 32 in in IN cord-302316-raf5rlkq 38 33 patients patient NNS cord-302316-raf5rlkq 38 34 < < NNP cord-302316-raf5rlkq 38 35 60 60 CD cord-302316-raf5rlkq 38 36 years year NNS cord-302316-raf5rlkq 39 1 ( ( -LRB- cord-302316-raf5rlkq 39 2 Lighter light JJR cord-302316-raf5rlkq 39 3 et et NNP cord-302316-raf5rlkq 39 4 al al NNP cord-302316-raf5rlkq 39 5 . . NNP cord-302316-raf5rlkq 39 6 , , , cord-302316-raf5rlkq 39 7 2020 2020 CD cord-302316-raf5rlkq 39 8 ) ) -RRB- cord-302316-raf5rlkq 39 9 . . . cord-302316-raf5rlkq 40 1 Clinicians clinician NNS cord-302316-raf5rlkq 40 2 had have VBD cord-302316-raf5rlkq 40 3 already already RB cord-302316-raf5rlkq 40 4 elaborated elaborate VBN cord-302316-raf5rlkq 40 5 concepts concept NNS cord-302316-raf5rlkq 40 6 for for IN cord-302316-raf5rlkq 40 7 COVID-19 covid-19 JJ cord-302316-raf5rlkq 40 8 pathogenesis pathogenesis NN cord-302316-raf5rlkq 40 9 that that WDT cord-302316-raf5rlkq 40 10 concur concur VBP cord-302316-raf5rlkq 40 11 with with IN cord-302316-raf5rlkq 40 12 these these DT cord-302316-raf5rlkq 40 13 observations observation NNS cord-302316-raf5rlkq 40 14 from from IN cord-302316-raf5rlkq 40 15 the the DT cord-302316-raf5rlkq 40 16 autopsies autopsy NNS cord-302316-raf5rlkq 40 17 . . . cord-302316-raf5rlkq 41 1 In in IN cord-302316-raf5rlkq 41 2 one one CD cord-302316-raf5rlkq 41 3 model model NN cord-302316-raf5rlkq 41 4 , , , cord-302316-raf5rlkq 41 5 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 41 6 patients patient NNS cord-302316-raf5rlkq 41 7 show show VBP cord-302316-raf5rlkq 41 8 a a DT cord-302316-raf5rlkq 41 9 diffuse diffuse JJ cord-302316-raf5rlkq 41 10 pulmonary pulmonary JJ cord-302316-raf5rlkq 41 11 intravascular intravascular JJ cord-302316-raf5rlkq 41 12 coagulopathy coagulopathy NN cord-302316-raf5rlkq 41 13 which which WDT cord-302316-raf5rlkq 41 14 isin isin NNP cord-302316-raf5rlkq 41 15 contrast contrast NN cord-302316-raf5rlkq 41 16 to to IN cord-302316-raf5rlkq 41 17 disseminated disseminate VBN cord-302316-raf5rlkq 41 18 intravascular intravascular JJ cord-302316-raf5rlkq 41 19 coagulation coagulation NN cord-302316-raf5rlkq 41 20 ( ( -LRB- cord-302316-raf5rlkq 41 21 DIC)restricted dic)restricte VBN cord-302316-raf5rlkq 41 22 to to IN cord-302316-raf5rlkq 41 23 the the DT cord-302316-raf5rlkq 41 24 lung lung NN cord-302316-raf5rlkq 41 25 vascular vascular JJ cord-302316-raf5rlkq 41 26 bed bed NN cord-302316-raf5rlkq 41 27 . . . cord-302316-raf5rlkq 42 1 The the DT cord-302316-raf5rlkq 42 2 increased increase VBN cord-302316-raf5rlkq 42 3 D d NN cord-302316-raf5rlkq 42 4 - - HYPH cord-302316-raf5rlkq 42 5 dimer dimer NN cord-302316-raf5rlkq 42 6 concentrations concentration NNS cord-302316-raf5rlkq 42 7 reflect reflect VBP cord-302316-raf5rlkq 42 8 the the DT cord-302316-raf5rlkq 42 9 pulmonary pulmonary JJ cord-302316-raf5rlkq 42 10 thrombosis thrombosis NN cord-302316-raf5rlkq 42 11 followed follow VBN cord-302316-raf5rlkq 42 12 by by IN cord-302316-raf5rlkq 42 13 fibrinolysis fibrinolysis NNP cord-302316-raf5rlkq 42 14 , , , cord-302316-raf5rlkq 42 15 and and CC cord-302316-raf5rlkq 42 16 the the DT cord-302316-raf5rlkq 42 17 elevated elevated JJ cord-302316-raf5rlkq 42 18 cardiac cardiac JJ cord-302316-raf5rlkq 42 19 enzymes enzyme NNS cord-302316-raf5rlkq 42 20 reflect reflect VBP cord-302316-raf5rlkq 42 21 the the DT cord-302316-raf5rlkq 42 22 stress stress NN cord-302316-raf5rlkq 42 23 imposed impose VBN cord-302316-raf5rlkq 42 24 on on IN cord-302316-raf5rlkq 42 25 the the DT cord-302316-raf5rlkq 42 26 heart heart NN cord-302316-raf5rlkq 42 27 ventricle ventricle NN cord-302316-raf5rlkq 42 28 by by IN cord-302316-raf5rlkq 42 29 pulmonary pulmonary JJ cord-302316-raf5rlkq 42 30 hypertension hypertension NN cord-302316-raf5rlkq 42 31 . . . cord-302316-raf5rlkq 43 1 According accord VBG cord-302316-raf5rlkq 43 2 to to IN cord-302316-raf5rlkq 43 3 this this DT cord-302316-raf5rlkq 43 4 model model NN cord-302316-raf5rlkq 43 5 , , , cord-302316-raf5rlkq 43 6 it -PRON- PRP cord-302316-raf5rlkq 43 7 is be VBZ cord-302316-raf5rlkq 43 8 not not RB cord-302316-raf5rlkq 43 9 the the DT cord-302316-raf5rlkq 43 10 viral viral JJ cord-302316-raf5rlkq 43 11 infection infection NN cord-302316-raf5rlkq 43 12 but but CC cord-302316-raf5rlkq 43 13 the the DT cord-302316-raf5rlkq 43 14 vascular vascular JJ cord-302316-raf5rlkq 43 15 thrombosis thrombosis NN cord-302316-raf5rlkq 43 16 induced induce VBN cord-302316-raf5rlkq 43 17 by by IN cord-302316-raf5rlkq 43 18 the the DT cord-302316-raf5rlkq 43 19 infection infection NN cord-302316-raf5rlkq 43 20 which which WDT cord-302316-raf5rlkq 43 21 underlies underlie VBZ cord-302316-raf5rlkq 43 22 the the DT cord-302316-raf5rlkq 43 23 severe severe JJ cord-302316-raf5rlkq 43 24 pathology pathology NN cord-302316-raf5rlkq 43 25 . . . cord-302316-raf5rlkq 44 1 The the DT cord-302316-raf5rlkq 44 2 coagulopathy coagulopathy NN cord-302316-raf5rlkq 44 3 might may MD cord-302316-raf5rlkq 44 4 be be VB cord-302316-raf5rlkq 44 5 caused cause VBN cord-302316-raf5rlkq 44 6 by by IN cord-302316-raf5rlkq 44 7 an an DT cord-302316-raf5rlkq 44 8 activation activation NN cord-302316-raf5rlkq 44 9 of of IN cord-302316-raf5rlkq 44 10 an an DT cord-302316-raf5rlkq 44 11 immune immune JJ cord-302316-raf5rlkq 44 12 mechanism mechanism NN cord-302316-raf5rlkq 44 13 involving involve VBG cord-302316-raf5rlkq 44 14 macrophages macrophage NNS cord-302316-raf5rlkq 44 15 as as IN cord-302316-raf5rlkq 44 16 observed observe VBN cord-302316-raf5rlkq 44 17 in in IN cord-302316-raf5rlkq 44 18 ' ' `` cord-302316-raf5rlkq 44 19 macrophage macrophage NN cord-302316-raf5rlkq 44 20 activation activation NN cord-302316-raf5rlkq 44 21 syndrome syndrome NN cord-302316-raf5rlkq 44 22 ' ' '' cord-302316-raf5rlkq 44 23 ( ( -LRB- cord-302316-raf5rlkq 44 24 MAS MAS NNP cord-302316-raf5rlkq 44 25 ) ) -RRB- cord-302316-raf5rlkq 44 26 , , , cord-302316-raf5rlkq 44 27 suggesting suggest VBG cord-302316-raf5rlkq 44 28 targets target NNS cord-302316-raf5rlkq 44 29 for for IN cord-302316-raf5rlkq 44 30 drug drug NN cord-302316-raf5rlkq 44 31 intervention intervention NN cord-302316-raf5rlkq 44 32 ( ( -LRB- cord-302316-raf5rlkq 44 33 McGonagle McGonagle NNP cord-302316-raf5rlkq 44 34 et et NNP cord-302316-raf5rlkq 44 35 al al NNP cord-302316-raf5rlkq 44 36 . . NNP cord-302316-raf5rlkq 44 37 , , , cord-302316-raf5rlkq 44 38 2020 2020 CD cord-302316-raf5rlkq 44 39 ) ) -RRB- cord-302316-raf5rlkq 44 40 . . . cord-302316-raf5rlkq 45 1 Another another DT cord-302316-raf5rlkq 45 2 popular popular JJ cord-302316-raf5rlkq 45 3 hypothesis hypothesis NN cord-302316-raf5rlkq 45 4 for for IN cord-302316-raf5rlkq 45 5 severe severe JJ cord-302316-raf5rlkq 45 6 COVID-19 covid-19 JJ cord-302316-raf5rlkq 45 7 pathology pathology NN cord-302316-raf5rlkq 45 8 is be VBZ cord-302316-raf5rlkq 45 9 based base VBN cord-302316-raf5rlkq 45 10 on on IN cord-302316-raf5rlkq 45 11 observations observation NNS cord-302316-raf5rlkq 45 12 of of IN cord-302316-raf5rlkq 45 13 acute acute JJ cord-302316-raf5rlkq 45 14 respiratory respiratory JJ cord-302316-raf5rlkq 45 15 distress distress NN cord-302316-raf5rlkq 45 16 syndrome syndrome NN cord-302316-raf5rlkq 45 17 ( ( -LRB- cord-302316-raf5rlkq 45 18 ARDS ARDS NNP cord-302316-raf5rlkq 45 19 ) ) -RRB- cord-302316-raf5rlkq 45 20 where where WRB cord-302316-raf5rlkq 45 21 pneumonia pneumonia NN cord-302316-raf5rlkq 45 22 , , , cord-302316-raf5rlkq 45 23 sepsis sepsis NN cord-302316-raf5rlkq 45 24 or or CC cord-302316-raf5rlkq 45 25 aspiration aspiration NN cord-302316-raf5rlkq 45 26 pneumonia pneumonia NN cord-302316-raf5rlkq 45 27 lead lead VBP cord-302316-raf5rlkq 45 28 via via IN cord-302316-raf5rlkq 45 29 a a DT cord-302316-raf5rlkq 45 30 release release NN cord-302316-raf5rlkq 45 31 of of IN cord-302316-raf5rlkq 45 32 pro pro JJ cord-302316-raf5rlkq 45 33 - - JJ cord-302316-raf5rlkq 45 34 inflammatory inflammatory JJ cord-302316-raf5rlkq 45 35 cytokines cytokine NNS cord-302316-raf5rlkq 45 36 from from IN cord-302316-raf5rlkq 45 37 immune immune JJ cord-302316-raf5rlkq 45 38 cells cell NNS cord-302316-raf5rlkq 45 39 ( ( -LRB- cord-302316-raf5rlkq 45 40 ' ' `` cord-302316-raf5rlkq 45 41 cytokine cytokine NN cord-302316-raf5rlkq 45 42 storm storm NN cord-302316-raf5rlkq 45 43 ' ' '' cord-302316-raf5rlkq 45 44 ) ) -RRB- cord-302316-raf5rlkq 45 45 to to IN cord-302316-raf5rlkq 45 46 severe severe JJ cord-302316-raf5rlkq 45 47 lung lung NN cord-302316-raf5rlkq 45 48 damage damage NN cord-302316-raf5rlkq 45 49 . . . cord-302316-raf5rlkq 46 1 In in IN cord-302316-raf5rlkq 46 2 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 46 3 , , , cord-302316-raf5rlkq 46 4 the the DT cord-302316-raf5rlkq 46 5 recruitment recruitment NN cord-302316-raf5rlkq 46 6 of of IN cord-302316-raf5rlkq 46 7 the the DT cord-302316-raf5rlkq 46 8 cellular cellular JJ cord-302316-raf5rlkq 46 9 virus virus NN cord-302316-raf5rlkq 46 10 receptor receptor NN cord-302316-raf5rlkq 46 11 by by IN cord-302316-raf5rlkq 46 12 the the DT cord-302316-raf5rlkq 46 13 infecting infect VBG cord-302316-raf5rlkq 46 14 virus virus NN cord-302316-raf5rlkq 46 15 causes cause VBZ cord-302316-raf5rlkq 46 16 disappearance disappearance NN cord-302316-raf5rlkq 46 17 of of IN cord-302316-raf5rlkq 46 18 the the DT cord-302316-raf5rlkq 46 19 angiotensin angiotensin NN cord-302316-raf5rlkq 46 20 - - HYPH cord-302316-raf5rlkq 46 21 converting convert VBG cord-302316-raf5rlkq 46 22 enzyme-2 enzyme-2 NNP cord-302316-raf5rlkq 46 23 ( ( -LRB- cord-302316-raf5rlkq 46 24 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 46 25 ) ) -RRB- cord-302316-raf5rlkq 46 26 from from IN cord-302316-raf5rlkq 46 27 the the DT cord-302316-raf5rlkq 46 28 cell cell NN cord-302316-raf5rlkq 46 29 surface surface NN cord-302316-raf5rlkq 46 30 and and CC cord-302316-raf5rlkq 46 31 by by IN cord-302316-raf5rlkq 46 32 its -PRON- PRP$ cord-302316-raf5rlkq 46 33 absence absence NN cord-302316-raf5rlkq 46 34 results result NNS cord-302316-raf5rlkq 46 35 in in IN cord-302316-raf5rlkq 46 36 an an DT cord-302316-raf5rlkq 46 37 increase increase NN cord-302316-raf5rlkq 46 38 in in IN cord-302316-raf5rlkq 46 39 unprocessed unprocessed JJ cord-302316-raf5rlkq 46 40 angiotensin angiotensin NN cord-302316-raf5rlkq 46 41 2 2 CD cord-302316-raf5rlkq 46 42 ( ( -LRB- cord-302316-raf5rlkq 46 43 Ang Ang NNP cord-302316-raf5rlkq 46 44 II II NNP cord-302316-raf5rlkq 46 45 ) ) -RRB- cord-302316-raf5rlkq 46 46 . . . cord-302316-raf5rlkq 47 1 Via via IN cord-302316-raf5rlkq 47 2 a a DT cord-302316-raf5rlkq 47 3 cascade cascade NN cord-302316-raf5rlkq 47 4 of of IN cord-302316-raf5rlkq 47 5 reactions reaction NNS cord-302316-raf5rlkq 47 6 involving involve VBG cord-302316-raf5rlkq 47 7 the the DT cord-302316-raf5rlkq 47 8 metalloproteinase metalloproteinase NN cord-302316-raf5rlkq 47 9 ADAM17 adam17 NN cord-302316-raf5rlkq 47 10 , , , cord-302316-raf5rlkq 47 11 increased increase VBD cord-302316-raf5rlkq 47 12 Ang Ang NNP cord-302316-raf5rlkq 47 13 II II NNP cord-302316-raf5rlkq 47 14 concentrations concentration NNS cord-302316-raf5rlkq 47 15 induce induce VBP cord-302316-raf5rlkq 47 16 the the DT cord-302316-raf5rlkq 47 17 cytokines cytokine NNS cord-302316-raf5rlkq 47 18 tumour tumour NN cord-302316-raf5rlkq 47 19 necrosis necrosis NN cord-302316-raf5rlkq 47 20 factor factor NN cord-302316-raf5rlkq 47 21 alpha alpha NN cord-302316-raf5rlkq 47 22 ( ( -LRB- cord-302316-raf5rlkq 47 23 TNF TNF NNP cord-302316-raf5rlkq 47 24 - - HYPH cord-302316-raf5rlkq 47 25 a a LS cord-302316-raf5rlkq 47 26 ) ) -RRB- cord-302316-raf5rlkq 47 27 and and CC cord-302316-raf5rlkq 47 28 interleukin interleukin NN cord-302316-raf5rlkq 47 29 6 6 CD cord-302316-raf5rlkq 47 30 ( ( -LRB- cord-302316-raf5rlkq 47 31 IL-6 IL-6 NNP cord-302316-raf5rlkq 47 32 ) ) -RRB- cord-302316-raf5rlkq 47 33 which which WDT cord-302316-raf5rlkq 47 34 activate activate VBP cord-302316-raf5rlkq 47 35 the the DT cord-302316-raf5rlkq 47 36 IL-6 IL-6 NNP cord-302316-raf5rlkq 47 37 amplifier amplifier NN cord-302316-raf5rlkq 47 38 ( ( -LRB- cord-302316-raf5rlkq 47 39 IL-6 IL-6 NNP cord-302316-raf5rlkq 47 40 AMP AMP NNP cord-302316-raf5rlkq 47 41 ) ) -RRB- cord-302316-raf5rlkq 47 42 , , , cord-302316-raf5rlkq 47 43 leading lead VBG cord-302316-raf5rlkq 47 44 to to IN cord-302316-raf5rlkq 47 45 the the DT cord-302316-raf5rlkq 47 46 release release NN cord-302316-raf5rlkq 47 47 of of IN cord-302316-raf5rlkq 47 48 inflammatory inflammatory JJ cord-302316-raf5rlkq 47 49 cytokines cytokine NNS cord-302316-raf5rlkq 47 50 . . . cord-302316-raf5rlkq 48 1 In in IN cord-302316-raf5rlkq 48 2 parallel parallel NN cord-302316-raf5rlkq 48 3 , , , cord-302316-raf5rlkq 48 4 the the DT cord-302316-raf5rlkq 48 5 virus virus NN cord-302316-raf5rlkq 48 6 induces induce VBZ cord-302316-raf5rlkq 48 7 inflammatory inflammatory JJ cord-302316-raf5rlkq 48 8 cytokines cytokine NNS cord-302316-raf5rlkq 48 9 by by IN cord-302316-raf5rlkq 48 10 activating activate VBG cord-302316-raf5rlkq 48 11 the the DT cord-302316-raf5rlkq 48 12 NF nf NN cord-302316-raf5rlkq 48 13 - - HYPH cord-302316-raf5rlkq 48 14 jB jb NN cord-302316-raf5rlkq 48 15 pathway pathway NN cord-302316-raf5rlkq 48 16 via via IN cord-302316-raf5rlkq 48 17 pattern pattern NN cord-302316-raf5rlkq 48 18 recognition recognition NN cord-302316-raf5rlkq 48 19 receptors receptor NNS cord-302316-raf5rlkq 48 20 ( ( -LRB- cord-302316-raf5rlkq 48 21 PRRs PRRs NNP cord-302316-raf5rlkq 48 22 ) ) -RRB- cord-302316-raf5rlkq 48 23 . . . cord-302316-raf5rlkq 49 1 This this DT cord-302316-raf5rlkq 49 2 hypothesis hypothesis NN cord-302316-raf5rlkq 49 3 explains explain VBZ cord-302316-raf5rlkq 49 4 much much JJ cord-302316-raf5rlkq 49 5 of of IN cord-302316-raf5rlkq 49 6 the the DT cord-302316-raf5rlkq 49 7 observed observed JJ cord-302316-raf5rlkq 49 8 pathology pathology NN cord-302316-raf5rlkq 49 9 in in IN cord-302316-raf5rlkq 49 10 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 49 11 and and CC cord-302316-raf5rlkq 49 12 suggests suggest VBZ cord-302316-raf5rlkq 49 13 a a DT cord-302316-raf5rlkq 49 14 number number NN cord-302316-raf5rlkq 49 15 of of IN cord-302316-raf5rlkq 49 16 targets target NNS cord-302316-raf5rlkq 49 17 for for IN cord-302316-raf5rlkq 49 18 pharmacological pharmacological JJ cord-302316-raf5rlkq 49 19 intervention intervention NN cord-302316-raf5rlkq 49 20 ( ( -LRB- cord-302316-raf5rlkq 49 21 Hirano Hirano NNP cord-302316-raf5rlkq 49 22 and and CC cord-302316-raf5rlkq 49 23 Murakami Murakami NNP cord-302316-raf5rlkq 49 24 , , , cord-302316-raf5rlkq 49 25 2020 2020 CD cord-302316-raf5rlkq 49 26 ) ) -RRB- cord-302316-raf5rlkq 49 27 . . . cord-302316-raf5rlkq 50 1 The the DT cord-302316-raf5rlkq 50 2 expression expression NN cord-302316-raf5rlkq 50 3 of of IN cord-302316-raf5rlkq 50 4 immune immune JJ cord-302316-raf5rlkq 50 5 genes gene NNS cord-302316-raf5rlkq 50 6 was be VBD cord-302316-raf5rlkq 50 7 studied study VBN cord-302316-raf5rlkq 50 8 in in IN cord-302316-raf5rlkq 50 9 3 3 CD cord-302316-raf5rlkq 51 1 COVID-19 covid-19 JJ cord-302316-raf5rlkq 51 2 patients patient NNS cord-302316-raf5rlkq 51 3 with with IN cord-302316-raf5rlkq 51 4 severe severe JJ cord-302316-raf5rlkq 51 5 , , , cord-302316-raf5rlkq 51 6 moderate moderate JJ cord-302316-raf5rlkq 51 7 and and CC cord-302316-raf5rlkq 51 8 mild mild JJ cord-302316-raf5rlkq 51 9 disease disease NN cord-302316-raf5rlkq 51 10 . . . cord-302316-raf5rlkq 52 1 Elevated elevated JJ cord-302316-raf5rlkq 52 2 plasma plasma NN cord-302316-raf5rlkq 52 3 levels level NNS cord-302316-raf5rlkq 52 4 of of IN cord-302316-raf5rlkq 52 5 pro pro JJ cord-302316-raf5rlkq 52 6 - - JJ cord-302316-raf5rlkq 52 7 inflammatory inflammatory JJ cord-302316-raf5rlkq 52 8 cytokines cytokine NNS cord-302316-raf5rlkq 52 9 ( ( -LRB- cord-302316-raf5rlkq 52 10 IL-1b IL-1b NNS cord-302316-raf5rlkq 52 11 , , , cord-302316-raf5rlkq 52 12 IL-8 IL-8 NNP cord-302316-raf5rlkq 52 13 and and CC cord-302316-raf5rlkq 52 14 TNF TNF NNP cord-302316-raf5rlkq 52 15 - - HYPH cord-302316-raf5rlkq 52 16 a a LS cord-302316-raf5rlkq 52 17 ) ) -RRB- cord-302316-raf5rlkq 52 18 were be VBD cord-302316-raf5rlkq 52 19 observed observe VBN cord-302316-raf5rlkq 52 20 , , , cord-302316-raf5rlkq 52 21 although although IN cord-302316-raf5rlkq 52 22 they -PRON- PRP cord-302316-raf5rlkq 52 23 occurred occur VBD cord-302316-raf5rlkq 52 24 after after IN cord-302316-raf5rlkq 52 25 the the DT cord-302316-raf5rlkq 52 26 peak peak NN cord-302316-raf5rlkq 52 27 of of IN cord-302316-raf5rlkq 52 28 respiratory respiratory JJ cord-302316-raf5rlkq 52 29 failure failure NN cord-302316-raf5rlkq 53 1 ( ( -LRB- cord-302316-raf5rlkq 53 2 Mehta Mehta NNP cord-302316-raf5rlkq 53 3 et et NNP cord-302316-raf5rlkq 53 4 al al NNP cord-302316-raf5rlkq 53 5 . . . cord-302316-raf5rlkq 54 1 , , , cord-302316-raf5rlkq 54 2 2020 2020 CD cord-302316-raf5rlkq 54 3 ; ; : cord-302316-raf5rlkq 54 4 Ong Ong NNP cord-302316-raf5rlkq 54 5 et et NNP cord-302316-raf5rlkq 54 6 al al NNP cord-302316-raf5rlkq 54 7 . . NNP cord-302316-raf5rlkq 54 8 , , , cord-302316-raf5rlkq 54 9 2020 2020 CD cord-302316-raf5rlkq 54 10 ) ) -RRB- cord-302316-raf5rlkq 54 11 . . . cord-302316-raf5rlkq 55 1 Only only RB cord-302316-raf5rlkq 55 2 5 5 CD cord-302316-raf5rlkq 55 3 % % NN cord-302316-raf5rlkq 55 4 of of IN cord-302316-raf5rlkq 56 1 COVID-19 covid-19 JJ cord-302316-raf5rlkq 56 2 cases case NNS cord-302316-raf5rlkq 56 3 show show VBP cord-302316-raf5rlkq 56 4 severe severe JJ cord-302316-raf5rlkq 56 5 infections infection NNS cord-302316-raf5rlkq 56 6 that that WDT cord-302316-raf5rlkq 56 7 lead lead VBP cord-302316-raf5rlkq 56 8 to to IN cord-302316-raf5rlkq 56 9 death death NN cord-302316-raf5rlkq 56 10 in in IN cord-302316-raf5rlkq 56 11 about about RB cord-302316-raf5rlkq 56 12 1.4 1.4 CD cord-302316-raf5rlkq 56 13 % % NN cord-302316-raf5rlkq 56 14 of of IN cord-302316-raf5rlkq 56 15 cases case NNS cord-302316-raf5rlkq 56 16 from from IN cord-302316-raf5rlkq 56 17 severe severe JJ cord-302316-raf5rlkq 56 18 lung lung NN cord-302316-raf5rlkq 56 19 injury injury NN cord-302316-raf5rlkq 56 20 and and CC cord-302316-raf5rlkq 56 21 multiorgan multiorgan NNP cord-302316-raf5rlkq 56 22 dysfunction dysfunction NN cord-302316-raf5rlkq 56 23 . . . cord-302316-raf5rlkq 57 1 Chinese chinese JJ cord-302316-raf5rlkq 57 2 clinicians clinician NNS cord-302316-raf5rlkq 57 3 observed observe VBD cord-302316-raf5rlkq 57 4 that that IN cord-302316-raf5rlkq 57 5 critically critically RB cord-302316-raf5rlkq 57 6 ill ill JJ cord-302316-raf5rlkq 57 7 patients patient NNS cord-302316-raf5rlkq 57 8 showed show VBD cord-302316-raf5rlkq 57 9 signs sign NNS cord-302316-raf5rlkq 57 10 of of IN cord-302316-raf5rlkq 57 11 shock shock NN cord-302316-raf5rlkq 57 12 with with IN cord-302316-raf5rlkq 57 13 cold cold JJ cord-302316-raf5rlkq 57 14 extremities extremity NNS cord-302316-raf5rlkq 57 15 , , , cord-302316-raf5rlkq 57 16 weak weak JJ cord-302316-raf5rlkq 57 17 peripheral peripheral JJ cord-302316-raf5rlkq 57 18 pulse pulse NN cord-302316-raf5rlkq 57 19 , , , cord-302316-raf5rlkq 57 20 metabolic metabolic JJ cord-302316-raf5rlkq 57 21 acidosis acidosis NN cord-302316-raf5rlkq 57 22 and and CC cord-302316-raf5rlkq 57 23 microcirculation microcirculation NN cord-302316-raf5rlkq 57 24 dysfunction dysfunction NN cord-302316-raf5rlkq 57 25 . . . cord-302316-raf5rlkq 58 1 This this DT cord-302316-raf5rlkq 58 2 combination combination NN cord-302316-raf5rlkq 58 3 of of IN cord-302316-raf5rlkq 58 4 symptoms symptom NNS cord-302316-raf5rlkq 58 5 suggests suggest VBZ cord-302316-raf5rlkq 58 6 septic septic JJ cord-302316-raf5rlkq 58 7 shock shock NN cord-302316-raf5rlkq 58 8 , , , cord-302316-raf5rlkq 58 9 but but CC cord-302316-raf5rlkq 58 10 in in IN cord-302316-raf5rlkq 58 11 76 76 CD cord-302316-raf5rlkq 58 12 % % NN cord-302316-raf5rlkq 58 13 of of IN cord-302316-raf5rlkq 58 14 these these DT cord-302316-raf5rlkq 58 15 patients patient NNS cord-302316-raf5rlkq 58 16 , , , cord-302316-raf5rlkq 58 17 SARS SARS NNP cord-302316-raf5rlkq 58 18 - - HYPH cord-302316-raf5rlkq 58 19 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 58 20 was be VBD cord-302316-raf5rlkq 58 21 the the DT cord-302316-raf5rlkq 58 22 only only JJ cord-302316-raf5rlkq 58 23 pathogen pathogen NN cord-302316-raf5rlkq 58 24 . . . cord-302316-raf5rlkq 59 1 These these DT cord-302316-raf5rlkq 59 2 researchers researcher NNS cord-302316-raf5rlkq 59 3 propose propose VBP cord-302316-raf5rlkq 59 4 ' ' `` cord-302316-raf5rlkq 59 5 viral viral JJ cord-302316-raf5rlkq 59 6 sepsis sepsis NN cord-302316-raf5rlkq 59 7 ' ' '' cord-302316-raf5rlkq 59 8 as as IN cord-302316-raf5rlkq 59 9 the the DT cord-302316-raf5rlkq 59 10 cause cause NN cord-302316-raf5rlkq 59 11 for for IN cord-302316-raf5rlkq 59 12 severe severe JJ cord-302316-raf5rlkq 59 13 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 59 14 , , , cord-302316-raf5rlkq 59 15 where where WRB cord-302316-raf5rlkq 59 16 the the DT cord-302316-raf5rlkq 59 17 virus virus NN cord-302316-raf5rlkq 59 18 infects infect VBZ cord-302316-raf5rlkq 59 19 the the DT cord-302316-raf5rlkq 59 20 lymphocytes lymphocyte NNS cord-302316-raf5rlkq 59 21 , , , cord-302316-raf5rlkq 59 22 induces induce VBZ cord-302316-raf5rlkq 59 23 detrimental detrimental JJ cord-302316-raf5rlkq 59 24 immune immune JJ cord-302316-raf5rlkq 59 25 reactions reaction NNS cord-302316-raf5rlkq 59 26 and and CC cord-302316-raf5rlkq 59 27 infects infect VBZ cord-302316-raf5rlkq 59 28 vascular vascular JJ cord-302316-raf5rlkq 59 29 epithelia epithelium NNS cord-302316-raf5rlkq 59 30 leading lead VBG cord-302316-raf5rlkq 59 31 to to IN cord-302316-raf5rlkq 59 32 disseminated disseminate VBN cord-302316-raf5rlkq 59 33 intravascular intravascular JJ cord-302316-raf5rlkq 59 34 coagulation coagulation NN cord-302316-raf5rlkq 59 35 . . . cord-302316-raf5rlkq 60 1 These these DT cord-302316-raf5rlkq 60 2 models model NNS cord-302316-raf5rlkq 60 3 of of IN cord-302316-raf5rlkq 60 4 COVID-19 covid-19 JJ cord-302316-raf5rlkq 60 5 pathogenesis pathogenesis NN cord-302316-raf5rlkq 60 6 are be VBP cord-302316-raf5rlkq 60 7 not not RB cord-302316-raf5rlkq 60 8 mutually mutually RB cord-302316-raf5rlkq 60 9 exclusive exclusive JJ cord-302316-raf5rlkq 60 10 . . . cord-302316-raf5rlkq 61 1 SARS SARS NNP cord-302316-raf5rlkq 61 2 - - HYPH cord-302316-raf5rlkq 61 3 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 61 4 infections infection NNS cord-302316-raf5rlkq 61 5 have have VBP cord-302316-raf5rlkq 61 6 a a DT cord-302316-raf5rlkq 61 7 variable variable JJ cord-302316-raf5rlkq 61 8 presentation presentation NN cord-302316-raf5rlkq 61 9 ranging range VBG cord-302316-raf5rlkq 61 10 from from IN cord-302316-raf5rlkq 61 11 causing cause VBG cord-302316-raf5rlkq 61 12 : : : cord-302316-raf5rlkq 61 13 no no DT cord-302316-raf5rlkq 61 14 symptoms symptom NNS cord-302316-raf5rlkq 61 15 ; ; : cord-302316-raf5rlkq 61 16 only only RB cord-302316-raf5rlkq 61 17 mild mild JJ cord-302316-raf5rlkq 61 18 symptoms symptom NNS cord-302316-raf5rlkq 61 19 ; ; : cord-302316-raf5rlkq 61 20 or or CC cord-302316-raf5rlkq 61 21 severe severe JJ cord-302316-raf5rlkq 61 22 disease disease NN cord-302316-raf5rlkq 61 23 necessitating necessitate VBG cord-302316-raf5rlkq 61 24 hospitalization hospitalization NN cord-302316-raf5rlkq 61 25 , , , cord-302316-raf5rlkq 61 26 if if IN cord-302316-raf5rlkq 61 27 not not RB cord-302316-raf5rlkq 61 28 intensive intensive JJ cord-302316-raf5rlkq 61 29 care care NN cord-302316-raf5rlkq 61 30 . . . cord-302316-raf5rlkq 62 1 In in IN cord-302316-raf5rlkq 62 2 addition addition NN cord-302316-raf5rlkq 62 3 , , , cord-302316-raf5rlkq 62 4 the the DT cord-302316-raf5rlkq 62 5 clinical clinical JJ cord-302316-raf5rlkq 62 6 presentation presentation NN cord-302316-raf5rlkq 62 7 differs differ VBZ cord-302316-raf5rlkq 62 8 with with IN cord-302316-raf5rlkq 62 9 severe severe JJ cord-302316-raf5rlkq 62 10 COVID-19 covid-19 JJ cord-302316-raf5rlkq 62 11 depending depend VBG cord-302316-raf5rlkq 62 12 whether whether IN cord-302316-raf5rlkq 62 13 diffuse diffuse JJ cord-302316-raf5rlkq 62 14 alveolar alveolar JJ cord-302316-raf5rlkq 62 15 damage damage NN cord-302316-raf5rlkq 62 16 , , , cord-302316-raf5rlkq 62 17 coagulopathy coagulopathy NN cord-302316-raf5rlkq 62 18 , , , cord-302316-raf5rlkq 62 19 cytokine cytokine NN cord-302316-raf5rlkq 62 20 overproduction overproduction NN cord-302316-raf5rlkq 62 21 or or CC cord-302316-raf5rlkq 62 22 viral viral JJ cord-302316-raf5rlkq 62 23 sepsis sepsis NN cord-302316-raf5rlkq 62 24 dominates dominate VBZ cord-302316-raf5rlkq 62 25 the the DT cord-302316-raf5rlkq 62 26 disease disease NN cord-302316-raf5rlkq 62 27 . . . cord-302316-raf5rlkq 63 1 Viral viral JJ cord-302316-raf5rlkq 63 2 sepsis sepsis NN cord-302316-raf5rlkq 63 3 and and CC cord-302316-raf5rlkq 63 4 cytokine cytokine NN cord-302316-raf5rlkq 63 5 storm storm NN cord-302316-raf5rlkq 63 6 might may MD cord-302316-raf5rlkq 63 7 , , , cord-302316-raf5rlkq 63 8 in in IN cord-302316-raf5rlkq 63 9 fact fact NN cord-302316-raf5rlkq 63 10 , , , cord-302316-raf5rlkq 63 11 be be VB cord-302316-raf5rlkq 63 12 connected connect VBN cord-302316-raf5rlkq 63 13 . . . cord-302316-raf5rlkq 64 1 Greek greek JJ cord-302316-raf5rlkq 64 2 researchers researcher NNS cord-302316-raf5rlkq 64 3 compared compare VBD cord-302316-raf5rlkq 64 4 immune immune JJ cord-302316-raf5rlkq 64 5 activation activation NN cord-302316-raf5rlkq 64 6 and and CC cord-302316-raf5rlkq 64 7 dysregulation dysregulation NN cord-302316-raf5rlkq 64 8 in in IN cord-302316-raf5rlkq 64 9 patients patient NNS cord-302316-raf5rlkq 64 10 with with IN cord-302316-raf5rlkq 64 11 pneumonia pneumonia NN cord-302316-raf5rlkq 64 12 caused cause VBN cord-302316-raf5rlkq 64 13 by by IN cord-302316-raf5rlkq 64 14 bacteria bacteria NNS cord-302316-raf5rlkq 64 15 , , , cord-302316-raf5rlkq 64 16 influenza influenza NN cord-302316-raf5rlkq 64 17 virus virus NN cord-302316-raf5rlkq 64 18 or or CC cord-302316-raf5rlkq 64 19 SARS SARS NNP cord-302316-raf5rlkq 64 20 - - HYPH cord-302316-raf5rlkq 64 21 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 64 22 . . . cord-302316-raf5rlkq 65 1 At at IN cord-302316-raf5rlkq 65 2 the the DT cord-302316-raf5rlkq 65 3 moment moment NN cord-302316-raf5rlkq 65 4 of of IN cord-302316-raf5rlkq 65 5 hospitalization hospitalization NN cord-302316-raf5rlkq 65 6 , , , cord-302316-raf5rlkq 65 7 COVID-19 covid-19 JJ cord-302316-raf5rlkq 65 8 patients patient NNS cord-302316-raf5rlkq 65 9 were be VBD cord-302316-raf5rlkq 65 10 clinically clinically RB cord-302316-raf5rlkq 65 11 less less RBR cord-302316-raf5rlkq 65 12 affected affected JJ cord-302316-raf5rlkq 65 13 than than IN cord-302316-raf5rlkq 65 14 patients patient NNS cord-302316-raf5rlkq 65 15 with with IN cord-302316-raf5rlkq 65 16 bacterial bacterial JJ cord-302316-raf5rlkq 65 17 pneumonia pneumonia NN cord-302316-raf5rlkq 65 18 . . . cord-302316-raf5rlkq 66 1 However however RB cord-302316-raf5rlkq 66 2 , , , cord-302316-raf5rlkq 66 3 a a DT cord-302316-raf5rlkq 66 4 common common JJ cord-302316-raf5rlkq 66 5 observation observation NN cord-302316-raf5rlkq 66 6 in in IN cord-302316-raf5rlkq 66 7 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 66 8 patients patient NNS cord-302316-raf5rlkq 66 9 is be VBZ cord-302316-raf5rlkq 66 10 that that IN cord-302316-raf5rlkq 66 11 one one CD cord-302316-raf5rlkq 66 12 week week NN cord-302316-raf5rlkq 66 13 after after IN cord-302316-raf5rlkq 66 14 hospitalization hospitalization NN cord-302316-raf5rlkq 66 15 they -PRON- PRP cord-302316-raf5rlkq 66 16 progressed progress VBD cord-302316-raf5rlkq 66 17 from from IN cord-302316-raf5rlkq 66 18 a a DT cord-302316-raf5rlkq 66 19 relatively relatively RB cord-302316-raf5rlkq 66 20 good good JJ cord-302316-raf5rlkq 66 21 clinical clinical JJ cord-302316-raf5rlkq 66 22 state state NN cord-302316-raf5rlkq 66 23 into into IN cord-302316-raf5rlkq 66 24 sudden sudden JJ cord-302316-raf5rlkq 66 25 deterioration deterioration NN cord-302316-raf5rlkq 66 26 . . . cord-302316-raf5rlkq 67 1 These these DT cord-302316-raf5rlkq 67 2 researchers researcher NNS cord-302316-raf5rlkq 67 3 observed observe VBD cord-302316-raf5rlkq 67 4 low low JJ cord-302316-raf5rlkq 67 5 expression expression NN cord-302316-raf5rlkq 67 6 of of IN cord-302316-raf5rlkq 67 7 the the DT cord-302316-raf5rlkq 67 8 human human JJ cord-302316-raf5rlkq 67 9 leucocyte leucocyte NNP cord-302316-raf5rlkq 67 10 antigen antigen NNP cord-302316-raf5rlkq 67 11 ( ( -LRB- cord-302316-raf5rlkq 67 12 HLA)-DR HLA)-DR NNP cord-302316-raf5rlkq 67 13 on on IN cord-302316-raf5rlkq 67 14 CD14 CD14 NNP cord-302316-raf5rlkq 67 15 monocytes monocyte NNS cord-302316-raf5rlkq 67 16 in in IN cord-302316-raf5rlkq 67 17 COVID-19 covid-19 CD cord-302316-raf5rlkq 67 18 patients patient NNS cord-302316-raf5rlkq 67 19 in in IN cord-302316-raf5rlkq 67 20 need need NN cord-302316-raf5rlkq 67 21 of of IN cord-302316-raf5rlkq 67 22 mechanical mechanical JJ cord-302316-raf5rlkq 67 23 ventilation ventilation NN cord-302316-raf5rlkq 67 24 . . . cord-302316-raf5rlkq 68 1 The the DT cord-302316-raf5rlkq 68 2 patients patient NNS cord-302316-raf5rlkq 68 3 showed show VBD cord-302316-raf5rlkq 68 4 a a DT cord-302316-raf5rlkq 68 5 unique unique JJ cord-302316-raf5rlkq 68 6 combination combination NN cord-302316-raf5rlkq 68 7 of of IN cord-302316-raf5rlkq 68 8 defective defective JJ cord-302316-raf5rlkq 68 9 antigen antigen NN cord-302316-raf5rlkq 68 10 presentation presentation NN cord-302316-raf5rlkq 68 11 and and CC cord-302316-raf5rlkq 68 12 lymphopenia lymphopenia NNP cord-302316-raf5rlkq 68 13 . . . cord-302316-raf5rlkq 69 1 Interleukin-6 Interleukin-6 NNP cord-302316-raf5rlkq 70 1 ( ( -LRB- cord-302316-raf5rlkq 70 2 IL-6 IL-6 NNP cord-302316-raf5rlkq 70 3 ) ) -RRB- cord-302316-raf5rlkq 70 4 and and CC cord-302316-raf5rlkq 70 5 C C NNP cord-302316-raf5rlkq 70 6 - - HYPH cord-302316-raf5rlkq 70 7 reactive reactive JJ cord-302316-raf5rlkq 70 8 protein protein NN cord-302316-raf5rlkq 70 9 ( ( -LRB- cord-302316-raf5rlkq 70 10 CRP CRP NNP cord-302316-raf5rlkq 70 11 ) ) -RRB- cord-302316-raf5rlkq 70 12 were be VBD cord-302316-raf5rlkq 70 13 significantly significantly RB cord-302316-raf5rlkq 70 14 increased increase VBN cord-302316-raf5rlkq 70 15 in in IN cord-302316-raf5rlkq 70 16 severe severe JJ cord-302316-raf5rlkq 70 17 cases case NNS cord-302316-raf5rlkq 70 18 . . . cord-302316-raf5rlkq 71 1 IL-6 IL-6 NNP cord-302316-raf5rlkq 71 2 is be VBZ cord-302316-raf5rlkq 71 3 known know VBN cord-302316-raf5rlkq 71 4 to to TO cord-302316-raf5rlkq 71 5 inhibit inhibit VB cord-302316-raf5rlkq 71 6 HLA HLA NNP cord-302316-raf5rlkq 71 7 - - HYPH cord-302316-raf5rlkq 71 8 DR DR NNP cord-302316-raf5rlkq 71 9 expression expression NN cord-302316-raf5rlkq 71 10 . . . cord-302316-raf5rlkq 72 1 An an DT cord-302316-raf5rlkq 72 2 inverse inverse JJ cord-302316-raf5rlkq 72 3 correlation correlation NN cord-302316-raf5rlkq 72 4 between between IN cord-302316-raf5rlkq 72 5 these these DT cord-302316-raf5rlkq 72 6 markers marker NNS cord-302316-raf5rlkq 72 7 was be VBD cord-302316-raf5rlkq 72 8 , , , cord-302316-raf5rlkq 72 9 in in IN cord-302316-raf5rlkq 72 10 fact fact NN cord-302316-raf5rlkq 72 11 , , , cord-302316-raf5rlkq 72 12 observed observe VBN cord-302316-raf5rlkq 72 13 in in IN cord-302316-raf5rlkq 72 14 severe severe JJ cord-302316-raf5rlkq 72 15 cases case NNS cord-302316-raf5rlkq 72 16 . . . cord-302316-raf5rlkq 73 1 The the DT cord-302316-raf5rlkq 73 2 authors author NNS cord-302316-raf5rlkq 73 3 of of IN cord-302316-raf5rlkq 73 4 this this DT cord-302316-raf5rlkq 73 5 study study NN cord-302316-raf5rlkq 73 6 suggest suggest VBP cord-302316-raf5rlkq 73 7 a a DT cord-302316-raf5rlkq 73 8 clinical clinical JJ cord-302316-raf5rlkq 73 9 trial trial NN cord-302316-raf5rlkq 73 10 exploring explore VBG cord-302316-raf5rlkq 73 11 a a DT cord-302316-raf5rlkq 73 12 specific specific JJ cord-302316-raf5rlkq 73 13 blocker blocker NN cord-302316-raf5rlkq 73 14 of of IN cord-302316-raf5rlkq 73 15 the the DT cord-302316-raf5rlkq 73 16 IL-6 IL-6 NNP cord-302316-raf5rlkq 73 17 pathway pathway NN cord-302316-raf5rlkq 73 18 such such JJ cord-302316-raf5rlkq 73 19 as as IN cord-302316-raf5rlkq 73 20 tocilizumab tocilizumab NNP cord-302316-raf5rlkq 73 21 to to TO cord-302316-raf5rlkq 73 22 restore restore VB cord-302316-raf5rlkq 73 23 the the DT cord-302316-raf5rlkq 73 24 expression expression NN cord-302316-raf5rlkq 73 25 of of IN cord-302316-raf5rlkq 73 26 HLA HLA NNP cord-302316-raf5rlkq 73 27 - - HYPH cord-302316-raf5rlkq 73 28 DR DR NNP cord-302316-raf5rlkq 73 29 , , , cord-302316-raf5rlkq 73 30 and and CC cord-302316-raf5rlkq 73 31 to to TO cord-302316-raf5rlkq 73 32 alleviate alleviate VB cord-302316-raf5rlkq 73 33 the the DT cord-302316-raf5rlkq 73 34 immune immune NN cord-302316-raf5rlkq 73 35 - - HYPH cord-302316-raf5rlkq 73 36 paralysis paralysis NN cord-302316-raf5rlkq 73 37 seen see VBN cord-302316-raf5rlkq 73 38 in in IN cord-302316-raf5rlkq 73 39 severe severe JJ cord-302316-raf5rlkq 73 40 COVID-19 covid-19 JJ cord-302316-raf5rlkq 73 41 cases case NNS cord-302316-raf5rlkq 73 42 . . . cord-302316-raf5rlkq 74 1 ( ( -LRB- cord-302316-raf5rlkq 74 2 Giamarellos Giamarellos NNP cord-302316-raf5rlkq 74 3 - - HYPH cord-302316-raf5rlkq 74 4 Bourboulis Bourboulis NNP cord-302316-raf5rlkq 74 5 et et NNP cord-302316-raf5rlkq 74 6 al al NNP cord-302316-raf5rlkq 74 7 . . NNP cord-302316-raf5rlkq 74 8 , , , cord-302316-raf5rlkq 74 9 2020 2020 CD cord-302316-raf5rlkq 74 10 ) ) -RRB- cord-302316-raf5rlkq 75 1 Data datum NNS cord-302316-raf5rlkq 75 2 from from IN cord-302316-raf5rlkq 75 3 Wuhan Wuhan NNP cord-302316-raf5rlkq 75 4 concur concur VBP cord-302316-raf5rlkq 75 5 with with IN cord-302316-raf5rlkq 75 6 these these DT cord-302316-raf5rlkq 75 7 observations observation NNS cord-302316-raf5rlkq 75 8 . . . cord-302316-raf5rlkq 76 1 When when WRB cord-302316-raf5rlkq 76 2 investigating investigate VBG cord-302316-raf5rlkq 76 3 48 48 CD cord-302316-raf5rlkq 76 4 COVID-19 covid-19 CD cord-302316-raf5rlkq 76 5 patients patient NNS cord-302316-raf5rlkq 76 6 with with IN cord-302316-raf5rlkq 76 7 distinct distinct JJ cord-302316-raf5rlkq 76 8 disease disease NN cord-302316-raf5rlkq 76 9 severity severity NN cord-302316-raf5rlkq 76 10 , , , cord-302316-raf5rlkq 76 11 the the DT cord-302316-raf5rlkq 76 12 clinicians clinician NNS cord-302316-raf5rlkq 76 13 observed observe VBD cord-302316-raf5rlkq 76 14 viral viral JJ cord-302316-raf5rlkq 76 15 RNA RNA NNP cord-302316-raf5rlkq 76 16 in in IN cord-302316-raf5rlkq 76 17 the the DT cord-302316-raf5rlkq 76 18 blood blood NN cord-302316-raf5rlkq 76 19 ( ( -LRB- cord-302316-raf5rlkq 76 20 ' ' `` cord-302316-raf5rlkq 76 21 RNAaemia rnaaemia NN cord-302316-raf5rlkq 76 22 ' ' '' cord-302316-raf5rlkq 76 23 ) ) -RRB- cord-302316-raf5rlkq 76 24 of of IN cord-302316-raf5rlkq 76 25 five five CD cord-302316-raf5rlkq 76 26 critically critically RB cord-302316-raf5rlkq 76 27 ill ill JJ cord-302316-raf5rlkq 76 28 patients patient NNS cord-302316-raf5rlkq 76 29 , , , cord-302316-raf5rlkq 76 30 two two CD cord-302316-raf5rlkq 76 31 of of IN cord-302316-raf5rlkq 76 32 whom whom WP cord-302316-raf5rlkq 76 33 died die VBD cord-302316-raf5rlkq 76 34 of of IN cord-302316-raf5rlkq 76 35 respiratory respiratory JJ cord-302316-raf5rlkq 76 36 failure failure NN cord-302316-raf5rlkq 76 37 . . . cord-302316-raf5rlkq 77 1 Interestingly interestingly RB cord-302316-raf5rlkq 77 2 , , , cord-302316-raf5rlkq 77 3 all all DT cord-302316-raf5rlkq 77 4 5 5 CD cord-302316-raf5rlkq 77 5 patients patient NNS cord-302316-raf5rlkq 77 6 also also RB cord-302316-raf5rlkq 77 7 showed show VBD cord-302316-raf5rlkq 77 8 sharply sharply RB cord-302316-raf5rlkq 77 9 increased increase VBN cord-302316-raf5rlkq 77 10 IL-6 IL-6 NNP cord-302316-raf5rlkq 77 11 levels level NNS cord-302316-raf5rlkq 77 12 . . . cord-302316-raf5rlkq 78 1 Viral Viral NNP cord-302316-raf5rlkq 78 2 RNA RNA NNP cord-302316-raf5rlkq 78 3 in in IN cord-302316-raf5rlkq 78 4 the the DT cord-302316-raf5rlkq 78 5 blood blood NN cord-302316-raf5rlkq 78 6 and and CC cord-302316-raf5rlkq 78 7 high high JJ cord-302316-raf5rlkq 78 8 IL-6 IL-6 NNP cord-302316-raf5rlkq 78 9 were be VBD cord-302316-raf5rlkq 78 10 biomarkers biomarker NNS cord-302316-raf5rlkq 78 11 of of IN cord-302316-raf5rlkq 78 12 severe severe JJ cord-302316-raf5rlkq 78 13 disease disease NN cord-302316-raf5rlkq 78 14 . . . cord-302316-raf5rlkq 79 1 Defence defence NN cord-302316-raf5rlkq 79 2 against against IN cord-302316-raf5rlkq 79 3 viral viral JJ cord-302316-raf5rlkq 79 4 infection infection NN cord-302316-raf5rlkq 79 5 begins begin VBZ cord-302316-raf5rlkq 79 6 at at IN cord-302316-raf5rlkq 79 7 the the DT cord-302316-raf5rlkq 79 8 cellular cellular JJ cord-302316-raf5rlkq 79 9 level level NN cord-302316-raf5rlkq 79 10 . . . cord-302316-raf5rlkq 80 1 Cells cell NNS cord-302316-raf5rlkq 80 2 detect detect VBP cord-302316-raf5rlkq 80 3 a a DT cord-302316-raf5rlkq 80 4 replicating replicate VBG cord-302316-raf5rlkq 80 5 virus virus NN cord-302316-raf5rlkq 80 6 by by IN cord-302316-raf5rlkq 80 7 pattern pattern NN cord-302316-raf5rlkq 80 8 recognition recognition NN cord-302316-raf5rlkq 80 9 receptors receptor NNS cord-302316-raf5rlkq 80 10 that that WDT cord-302316-raf5rlkq 80 11 signal signal VBP cord-302316-raf5rlkq 80 12 the the DT cord-302316-raf5rlkq 80 13 presence presence NN cord-302316-raf5rlkq 80 14 of of IN cord-302316-raf5rlkq 80 15 unusual unusual JJ cord-302316-raf5rlkq 80 16 RNA RNA NNP cord-302316-raf5rlkq 80 17 structures structure NNS cord-302316-raf5rlkq 80 18 . . . cord-302316-raf5rlkq 81 1 These these DT cord-302316-raf5rlkq 81 2 receptors receptor NNS cord-302316-raf5rlkq 81 3 , , , cord-302316-raf5rlkq 81 4 when when WRB cord-302316-raf5rlkq 81 5 bound bind VBN cord-302316-raf5rlkq 81 6 to to IN cord-302316-raf5rlkq 81 7 these these DT cord-302316-raf5rlkq 81 8 aberrant aberrant JJ cord-302316-raf5rlkq 81 9 RNA RNA NNP cord-302316-raf5rlkq 81 10 molecules molecule NNS cord-302316-raf5rlkq 81 11 , , , cord-302316-raf5rlkq 81 12 activate activate VBP cord-302316-raf5rlkq 81 13 the the DT cord-302316-raf5rlkq 81 14 transcription transcription NN cord-302316-raf5rlkq 81 15 factors factor NNS cord-302316-raf5rlkq 81 16 IRF IRF NNP cord-302316-raf5rlkq 81 17 and and CC cord-302316-raf5rlkq 81 18 NF NF NNP cord-302316-raf5rlkq 81 19 - - HYPH cord-302316-raf5rlkq 81 20 jB jB NNP cord-302316-raf5rlkq 81 21 , , , cord-302316-raf5rlkq 81 22 which which WDT cord-302316-raf5rlkq 81 23 launch launch VBP cord-302316-raf5rlkq 81 24 two two CD cord-302316-raf5rlkq 81 25 antiviral antiviral JJ cord-302316-raf5rlkq 81 26 programmes programme NNS cord-302316-raf5rlkq 81 27 : : : cord-302316-raf5rlkq 81 28 ( ( -LRB- cord-302316-raf5rlkq 81 29 i i NN cord-302316-raf5rlkq 81 30 ) ) -RRB- cord-302316-raf5rlkq 81 31 induction induction NN cord-302316-raf5rlkq 81 32 of of IN cord-302316-raf5rlkq 81 33 type type NN cord-302316-raf5rlkq 81 34 I -PRON- PRP cord-302316-raf5rlkq 81 35 and and CC cord-302316-raf5rlkq 81 36 III III NNP cord-302316-raf5rlkq 82 1 interferon interferon NNP cord-302316-raf5rlkq 83 1 ( ( -LRB- cord-302316-raf5rlkq 83 2 INF INF NNP cord-302316-raf5rlkq 83 3 - - HYPH cord-302316-raf5rlkq 83 4 I I NNP cord-302316-raf5rlkq 83 5 , , , cord-302316-raf5rlkq 83 6 INF INF NNP cord-302316-raf5rlkq 83 7 - - HYPH cord-302316-raf5rlkq 83 8 III III NNP cord-302316-raf5rlkq 83 9 ) ) -RRB- cord-302316-raf5rlkq 83 10 , , , cord-302316-raf5rlkq 83 11 which which WDT cord-302316-raf5rlkq 83 12 upregulate upregulate VBP cord-302316-raf5rlkq 83 13 interferon interferon NN cord-302316-raf5rlkq 83 14 - - HYPH cord-302316-raf5rlkq 83 15 stimulated stimulate VBN cord-302316-raf5rlkq 83 16 genes gene NNS cord-302316-raf5rlkq 83 17 ( ( -LRB- cord-302316-raf5rlkq 83 18 ISG ISG NNP cord-302316-raf5rlkq 83 19 ) ) -RRB- cord-302316-raf5rlkq 83 20 ; ; : cord-302316-raf5rlkq 83 21 ( ( -LRB- cord-302316-raf5rlkq 83 22 ii ii NN cord-302316-raf5rlkq 83 23 ) ) -RRB- cord-302316-raf5rlkq 83 24 recruitment recruitment NN cord-302316-raf5rlkq 83 25 of of IN cord-302316-raf5rlkq 83 26 specific specific JJ cord-302316-raf5rlkq 83 27 leucocytes leucocyte NNS cord-302316-raf5rlkq 83 28 by by IN cord-302316-raf5rlkq 83 29 chemokine chemokine NN cord-302316-raf5rlkq 83 30 secretion secretion NN cord-302316-raf5rlkq 83 31 . . . cord-302316-raf5rlkq 84 1 US US NNP cord-302316-raf5rlkq 84 2 researchers researcher NNS cord-302316-raf5rlkq 84 3 studied study VBD cord-302316-raf5rlkq 84 4 the the DT cord-302316-raf5rlkq 84 5 viral viral JJ cord-302316-raf5rlkq 84 6 and and CC cord-302316-raf5rlkq 84 7 cellular cellular JJ cord-302316-raf5rlkq 84 8 transcriptional transcriptional JJ cord-302316-raf5rlkq 84 9 response response NN cord-302316-raf5rlkq 84 10 upon upon IN cord-302316-raf5rlkq 84 11 infection infection NN cord-302316-raf5rlkq 84 12 of of IN cord-302316-raf5rlkq 84 13 cell cell NN cord-302316-raf5rlkq 84 14 cultures culture NNS cord-302316-raf5rlkq 84 15 and and CC cord-302316-raf5rlkq 84 16 in in IN cord-302316-raf5rlkq 84 17 animal animal NN cord-302316-raf5rlkq 84 18 models model NNS cord-302316-raf5rlkq 84 19 with with IN cord-302316-raf5rlkq 84 20 different different JJ cord-302316-raf5rlkq 84 21 respiratory respiratory JJ cord-302316-raf5rlkq 84 22 viruses virus NNS cord-302316-raf5rlkq 84 23 including include VBG cord-302316-raf5rlkq 84 24 influenza influenza NN cord-302316-raf5rlkq 84 25 A a DT cord-302316-raf5rlkq 84 26 virus virus NN cord-302316-raf5rlkq 84 27 and and CC cord-302316-raf5rlkq 84 28 SARS SARS NNP cord-302316-raf5rlkq 84 29 - - HYPH cord-302316-raf5rlkq 84 30 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 84 31 . . . cord-302316-raf5rlkq 85 1 In in IN cord-302316-raf5rlkq 85 2 cell cell NN cord-302316-raf5rlkq 85 3 culture culture NN cord-302316-raf5rlkq 85 4 , , , cord-302316-raf5rlkq 85 5 viral viral JJ cord-302316-raf5rlkq 85 6 RNA RNA NNP cord-302316-raf5rlkq 85 7 represented represent VBD cord-302316-raf5rlkq 85 8 50 50 CD cord-302316-raf5rlkq 85 9 % % NN cord-302316-raf5rlkq 85 10 or or CC cord-302316-raf5rlkq 85 11 more more JJR cord-302316-raf5rlkq 85 12 of of IN cord-302316-raf5rlkq 85 13 all all DT cord-302316-raf5rlkq 85 14 cellular cellular JJ cord-302316-raf5rlkq 85 15 messenger messenger NN cord-302316-raf5rlkq 85 16 RNA RNA NNP cord-302316-raf5rlkq 85 17 ( ( -LRB- cord-302316-raf5rlkq 85 18 mRNA mrna NN cord-302316-raf5rlkq 85 19 ) ) -RRB- cord-302316-raf5rlkq 85 20 . . . cord-302316-raf5rlkq 86 1 The the DT cord-302316-raf5rlkq 86 2 external external JJ cord-302316-raf5rlkq 86 3 addition addition NN cord-302316-raf5rlkq 86 4 of of IN cord-302316-raf5rlkq 86 5 INF INF NNP cord-302316-raf5rlkq 86 6 - - : cord-302316-raf5rlkq 86 7 I I NNP cord-302316-raf5rlkq 86 8 reduced reduce VBD cord-302316-raf5rlkq 86 9 SARS SARS NNP cord-302316-raf5rlkq 86 10 - - HYPH cord-302316-raf5rlkq 86 11 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 86 12 replication replication NN cord-302316-raf5rlkq 86 13 dramatically dramatically RB cord-302316-raf5rlkq 86 14 . . . cord-302316-raf5rlkq 87 1 However however RB cord-302316-raf5rlkq 87 2 , , , cord-302316-raf5rlkq 87 3 infection infection NN cord-302316-raf5rlkq 87 4 of of IN cord-302316-raf5rlkq 87 5 cells cell NNS cord-302316-raf5rlkq 87 6 with with IN cord-302316-raf5rlkq 87 7 SARS SARS NNP cord-302316-raf5rlkq 87 8 - - HYPH cord-302316-raf5rlkq 87 9 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 87 10 did do VBD cord-302316-raf5rlkq 87 11 not not RB cord-302316-raf5rlkq 87 12 induce induce VB cord-302316-raf5rlkq 87 13 an an DT cord-302316-raf5rlkq 87 14 interferon interferon NN cord-302316-raf5rlkq 87 15 response response NN cord-302316-raf5rlkq 87 16 , , , cord-302316-raf5rlkq 87 17 but but CC cord-302316-raf5rlkq 87 18 a a DT cord-302316-raf5rlkq 87 19 strong strong JJ cord-302316-raf5rlkq 87 20 chemotactic chemotactic JJ cord-302316-raf5rlkq 87 21 and and CC cord-302316-raf5rlkq 87 22 inflammatory inflammatory JJ cord-302316-raf5rlkq 87 23 response response NN cord-302316-raf5rlkq 87 24 instead instead RB cord-302316-raf5rlkq 87 25 . . . cord-302316-raf5rlkq 88 1 In in IN cord-302316-raf5rlkq 88 2 nasal nasal JJ cord-302316-raf5rlkq 88 3 washes wash NNS cord-302316-raf5rlkq 88 4 from from IN cord-302316-raf5rlkq 88 5 infected infected JJ cord-302316-raf5rlkq 88 6 ferrets ferret NNS cord-302316-raf5rlkq 88 7 , , , cord-302316-raf5rlkq 88 8 viral viral JJ cord-302316-raf5rlkq 88 9 RNA RNA NNP cord-302316-raf5rlkq 88 10 represented represent VBD cord-302316-raf5rlkq 88 11 < < XX cord-302316-raf5rlkq 88 12 2 2 CD cord-302316-raf5rlkq 88 13 % % NN cord-302316-raf5rlkq 88 14 of of IN cord-302316-raf5rlkq 88 15 all all DT cord-302316-raf5rlkq 88 16 mRNA mrna NN cord-302316-raf5rlkq 88 17 . . . cord-302316-raf5rlkq 89 1 SARS SARS NNP cord-302316-raf5rlkq 89 2 - - HYPH cord-302316-raf5rlkq 89 3 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 89 4 induced induce VBD cord-302316-raf5rlkq 89 5 a a DT cord-302316-raf5rlkq 89 6 different different JJ cord-302316-raf5rlkq 89 7 cellular cellular JJ cord-302316-raf5rlkq 89 8 transcription transcription NN cord-302316-raf5rlkq 89 9 response response NN cord-302316-raf5rlkq 89 10 compared compare VBN cord-302316-raf5rlkq 89 11 to to IN cord-302316-raf5rlkq 89 12 the the DT cord-302316-raf5rlkq 89 13 influenza influenza NN cord-302316-raf5rlkq 89 14 virus virus NN cord-302316-raf5rlkq 89 15 : : : cord-302316-raf5rlkq 89 16 a a DT cord-302316-raf5rlkq 89 17 cytokine cytokine NN cord-302316-raf5rlkq 89 18 response response NN cord-302316-raf5rlkq 89 19 was be VBD cord-302316-raf5rlkq 89 20 followed follow VBN cord-302316-raf5rlkq 89 21 by by IN cord-302316-raf5rlkq 89 22 gene gene NN cord-302316-raf5rlkq 89 23 transcripts transcript NNS cord-302316-raf5rlkq 89 24 of of IN cord-302316-raf5rlkq 89 25 cell cell NN cord-302316-raf5rlkq 89 26 death death NN cord-302316-raf5rlkq 89 27 and and CC cord-302316-raf5rlkq 89 28 leucocyte leucocyte NNP cord-302316-raf5rlkq 89 29 activation activation NN cord-302316-raf5rlkq 89 30 . . . cord-302316-raf5rlkq 90 1 Postmortem postmortem JJ cord-302316-raf5rlkq 90 2 lung lung NN cord-302316-raf5rlkq 90 3 samples sample NNS cord-302316-raf5rlkq 90 4 from from IN cord-302316-raf5rlkq 90 5 COVID-19 covid-19 CD cord-302316-raf5rlkq 90 6 patients patient NNS cord-302316-raf5rlkq 90 7 showed show VBD cord-302316-raf5rlkq 90 8 no no DT cord-302316-raf5rlkq 90 9 INF inf NN cord-302316-raf5rlkq 90 10 - - HYPH cord-302316-raf5rlkq 90 11 I I NNP cord-302316-raf5rlkq 90 12 and and CC cord-302316-raf5rlkq 90 13 INF INF NNP cord-302316-raf5rlkq 90 14 - - HYPH cord-302316-raf5rlkq 90 15 III III NNP cord-302316-raf5rlkq 90 16 , , , cord-302316-raf5rlkq 90 17 but but CC cord-302316-raf5rlkq 90 18 a a DT cord-302316-raf5rlkq 90 19 robust robust JJ cord-302316-raf5rlkq 90 20 chemokine chemokine NN cord-302316-raf5rlkq 90 21 transcription transcription NN cord-302316-raf5rlkq 90 22 instead instead RB cord-302316-raf5rlkq 90 23 . . . cord-302316-raf5rlkq 91 1 The the DT cord-302316-raf5rlkq 91 2 observations observation NNS cord-302316-raf5rlkq 91 3 were be VBD cord-302316-raf5rlkq 91 4 confirmed confirm VBN cord-302316-raf5rlkq 91 5 in in IN cord-302316-raf5rlkq 91 6 serum serum NN cord-302316-raf5rlkq 91 7 samples sample NNS cord-302316-raf5rlkq 91 8 of of IN cord-302316-raf5rlkq 91 9 COVID-19 covid-19 JJ cord-302316-raf5rlkq 91 10 patients patient NNS cord-302316-raf5rlkq 91 11 compared compare VBN cord-302316-raf5rlkq 91 12 with with IN cord-302316-raf5rlkq 91 13 samples sample NNS cord-302316-raf5rlkq 91 14 from from IN cord-302316-raf5rlkq 91 15 control control NN cord-302316-raf5rlkq 91 16 subjects subject NNS cord-302316-raf5rlkq 91 17 , , , cord-302316-raf5rlkq 91 18 showing show VBG cord-302316-raf5rlkq 91 19 no no DT cord-302316-raf5rlkq 91 20 interferon interferon NN cord-302316-raf5rlkq 91 21 , , , cord-302316-raf5rlkq 91 22 but but CC cord-302316-raf5rlkq 91 23 a a DT cord-302316-raf5rlkq 91 24 cytokine cytokine NN cord-302316-raf5rlkq 91 25 response response NN cord-302316-raf5rlkq 91 26 . . . cord-302316-raf5rlkq 92 1 The the DT cord-302316-raf5rlkq 92 2 data datum NNS cord-302316-raf5rlkq 92 3 suggest suggest VBP cord-302316-raf5rlkq 92 4 that that IN cord-302316-raf5rlkq 92 5 SARS SARS NNP cord-302316-raf5rlkq 92 6 - - HYPH cord-302316-raf5rlkq 92 7 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 92 8 has have VBZ cord-302316-raf5rlkq 92 9 learned learn VBN cord-302316-raf5rlkq 92 10 to to TO cord-302316-raf5rlkq 92 11 suppress suppress VB cord-302316-raf5rlkq 92 12 interferon interferon NN cord-302316-raf5rlkq 92 13 induction induction NN cord-302316-raf5rlkq 92 14 and and CC cord-302316-raf5rlkq 92 15 to to TO cord-302316-raf5rlkq 92 16 disarray disarray VB cord-302316-raf5rlkq 92 17 the the DT cord-302316-raf5rlkq 92 18 antiviral antiviral JJ cord-302316-raf5rlkq 92 19 response response NN cord-302316-raf5rlkq 92 20 ( ( -LRB- cord-302316-raf5rlkq 92 21 Blanco Blanco NNP cord-302316-raf5rlkq 92 22 - - HYPH cord-302316-raf5rlkq 92 23 Melo Melo NNP cord-302316-raf5rlkq 92 24 et et NNP cord-302316-raf5rlkq 92 25 al al NNP cord-302316-raf5rlkq 92 26 . . NNP cord-302316-raf5rlkq 92 27 , , , cord-302316-raf5rlkq 92 28 2020 2020 CD cord-302316-raf5rlkq 92 29 ) ) -RRB- cord-302316-raf5rlkq 92 30 . . . cord-302316-raf5rlkq 93 1 Another another DT cord-302316-raf5rlkq 93 2 impressive impressive JJ cord-302316-raf5rlkq 93 3 US US NNP cord-302316-raf5rlkq 93 4 study study NN cord-302316-raf5rlkq 93 5 , , , cord-302316-raf5rlkq 93 6 so so RB cord-302316-raf5rlkq 93 7 far far RB cord-302316-raf5rlkq 93 8 only only RB cord-302316-raf5rlkq 93 9 available available JJ cord-302316-raf5rlkq 93 10 as as IN cord-302316-raf5rlkq 93 11 a a DT cord-302316-raf5rlkq 93 12 preprint preprint NN cord-302316-raf5rlkq 93 13 , , , cord-302316-raf5rlkq 93 14 investigated investigate VBD cord-302316-raf5rlkq 93 15 the the DT cord-302316-raf5rlkq 93 16 expression expression NN cord-302316-raf5rlkq 93 17 of of IN cord-302316-raf5rlkq 93 18 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 93 19 , , , cord-302316-raf5rlkq 93 20 the the DT cord-302316-raf5rlkq 93 21 viral viral JJ cord-302316-raf5rlkq 93 22 receptor receptor NN cord-302316-raf5rlkq 93 23 of of IN cord-302316-raf5rlkq 93 24 SARS SARS NNP cord-302316-raf5rlkq 93 25 - - HYPH cord-302316-raf5rlkq 93 26 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 93 27 , , , cord-302316-raf5rlkq 93 28 and and CC cord-302316-raf5rlkq 93 29 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 93 30 , , , cord-302316-raf5rlkq 93 31 the the DT cord-302316-raf5rlkq 93 32 protease protease NN cord-302316-raf5rlkq 93 33 activating activate VBG cord-302316-raf5rlkq 93 34 viral viral JJ cord-302316-raf5rlkq 93 35 fusion fusion NN cord-302316-raf5rlkq 93 36 with with IN cord-302316-raf5rlkq 93 37 cell cell NN cord-302316-raf5rlkq 93 38 membranes membrane NNS cord-302316-raf5rlkq 93 39 leading lead VBG cord-302316-raf5rlkq 93 40 to to IN cord-302316-raf5rlkq 93 41 cell cell NN cord-302316-raf5rlkq 93 42 entry entry NN cord-302316-raf5rlkq 93 43 , , , cord-302316-raf5rlkq 93 44 in in IN cord-302316-raf5rlkq 93 45 a a DT cord-302316-raf5rlkq 93 46 large large JJ cord-302316-raf5rlkq 93 47 set set NN cord-302316-raf5rlkq 93 48 of of IN cord-302316-raf5rlkq 93 49 695 695 CD cord-302316-raf5rlkq 93 50 healthy healthy JJ cord-302316-raf5rlkq 93 51 and and CC cord-302316-raf5rlkq 93 52 asthmatic asthmatic JJ cord-302316-raf5rlkq 93 53 children child NNS cord-302316-raf5rlkq 93 54 from from IN cord-302316-raf5rlkq 93 55 Puerto Puerto NNP cord-302316-raf5rlkq 93 56 Rico Rico NNP cord-302316-raf5rlkq 93 57 ( ( -LRB- cord-302316-raf5rlkq 93 58 Gala Gala NNP cord-302316-raf5rlkq 93 59 II II NNP cord-302316-raf5rlkq 93 60 study study NN cord-302316-raf5rlkq 93 61 ) ) -RRB- cord-302316-raf5rlkq 93 62 . . . cord-302316-raf5rlkq 94 1 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 94 2 expression expression NN cord-302316-raf5rlkq 94 3 was be VBD cord-302316-raf5rlkq 94 4 highly highly RB cord-302316-raf5rlkq 94 5 correlated correlate VBN cord-302316-raf5rlkq 94 6 with with IN cord-302316-raf5rlkq 94 7 the the DT cord-302316-raf5rlkq 94 8 expression expression NN cord-302316-raf5rlkq 94 9 of of IN cord-302316-raf5rlkq 94 10 a a DT cord-302316-raf5rlkq 94 11 gene gene NN cord-302316-raf5rlkq 94 12 network network NN cord-302316-raf5rlkq 94 13 associated associate VBN cord-302316-raf5rlkq 94 14 with with IN cord-302316-raf5rlkq 94 15 cytotoxic cytotoxic JJ cord-302316-raf5rlkq 94 16 T t NN cord-302316-raf5rlkq 94 17 cells cell NNS cord-302316-raf5rlkq 94 18 , , , cord-302316-raf5rlkq 94 19 induced induce VBN cord-302316-raf5rlkq 94 20 in in IN cord-302316-raf5rlkq 94 21 virally virally RB cord-302316-raf5rlkq 94 22 infected infect VBN cord-302316-raf5rlkq 94 23 epithelia epithelium NNS cord-302316-raf5rlkq 94 24 and and CC cord-302316-raf5rlkq 94 25 correlated correlate VBN cord-302316-raf5rlkq 94 26 with with IN cord-302316-raf5rlkq 94 27 a a DT cord-302316-raf5rlkq 94 28 network network NN cord-302316-raf5rlkq 94 29 of of IN cord-302316-raf5rlkq 94 30 interferon interferon NN cord-302316-raf5rlkq 94 31 and and CC cord-302316-raf5rlkq 94 32 epithelial epithelial JJ cord-302316-raf5rlkq 94 33 viral viral JJ cord-302316-raf5rlkq 94 34 response response NN cord-302316-raf5rlkq 94 35 genes gene NNS cord-302316-raf5rlkq 94 36 . . . cord-302316-raf5rlkq 95 1 Notably notably RB cord-302316-raf5rlkq 95 2 , , , cord-302316-raf5rlkq 95 3 78 78 CD cord-302316-raf5rlkq 95 4 % % NN cord-302316-raf5rlkq 95 5 of of IN cord-302316-raf5rlkq 95 6 subjects subject NNS cord-302316-raf5rlkq 95 7 showing show VBG cord-302316-raf5rlkq 95 8 high high JJ cord-302316-raf5rlkq 95 9 interferon interferon NN cord-302316-raf5rlkq 95 10 levels level NNS cord-302316-raf5rlkq 95 11 were be VBD cord-302316-raf5rlkq 95 12 asymptomatic asymptomatic JJ cord-302316-raf5rlkq 95 13 respiratory respiratory JJ cord-302316-raf5rlkq 95 14 virus virus NN cord-302316-raf5rlkq 95 15 carriers carrier NNS cord-302316-raf5rlkq 95 16 ( ( -LRB- cord-302316-raf5rlkq 95 17 not not RB cord-302316-raf5rlkq 95 18 with with IN cord-302316-raf5rlkq 95 19 SARS SARS NNP cord-302316-raf5rlkq 95 20 - - HYPH cord-302316-raf5rlkq 95 21 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 95 22 , , , cord-302316-raf5rlkq 95 23 the the DT cord-302316-raf5rlkq 95 24 study study NN cord-302316-raf5rlkq 95 25 preceded precede VBD cord-302316-raf5rlkq 95 26 the the DT cord-302316-raf5rlkq 95 27 epidemic epidemic NN cord-302316-raf5rlkq 95 28 ) ) -RRB- cord-302316-raf5rlkq 95 29 compared compare VBN cord-302316-raf5rlkq 95 30 with with IN cord-302316-raf5rlkq 95 31 10 10 CD cord-302316-raf5rlkq 95 32 % % NN cord-302316-raf5rlkq 95 33 asymptomatic asymptomatic JJ cord-302316-raf5rlkq 95 34 infections infection NNS cord-302316-raf5rlkq 95 35 in in IN cord-302316-raf5rlkq 95 36 subjects subject NNS cord-302316-raf5rlkq 95 37 displaying display VBG cord-302316-raf5rlkq 95 38 only only RB cord-302316-raf5rlkq 95 39 low low JJ cord-302316-raf5rlkq 95 40 interferon interferon NN cord-302316-raf5rlkq 95 41 levels level NNS cord-302316-raf5rlkq 95 42 . . . cord-302316-raf5rlkq 96 1 Eighteen eighteen CD cord-302316-raf5rlkq 96 2 children child NNS cord-302316-raf5rlkq 96 3 were be VBD cord-302316-raf5rlkq 96 4 infected infect VBN cord-302316-raf5rlkq 96 5 with with IN cord-302316-raf5rlkq 96 6 seasonal seasonal JJ cord-302316-raf5rlkq 96 7 coronaviruses coronaviruse NNS cord-302316-raf5rlkq 96 8 , , , cord-302316-raf5rlkq 96 9 and and CC cord-302316-raf5rlkq 96 10 they -PRON- PRP cord-302316-raf5rlkq 96 11 demonstrated demonstrate VBD cord-302316-raf5rlkq 96 12 an an DT cord-302316-raf5rlkq 96 13 increased increase VBN cord-302316-raf5rlkq 96 14 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 96 15 expression expression NN cord-302316-raf5rlkq 96 16 . . . cord-302316-raf5rlkq 97 1 The the DT cord-302316-raf5rlkq 97 2 researchers researcher NNS cord-302316-raf5rlkq 97 3 correlated correlate VBD cord-302316-raf5rlkq 97 4 nasal nasal NN cord-302316-raf5rlkq 97 5 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 97 6 and and CC cord-302316-raf5rlkq 97 7 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 97 8 gene gene NN cord-302316-raf5rlkq 97 9 expression expression NN cord-302316-raf5rlkq 97 10 with with IN cord-302316-raf5rlkq 97 11 genome genome NN cord-302316-raf5rlkq 97 12 wide wide JJ cord-302316-raf5rlkq 97 13 genetic genetic JJ cord-302316-raf5rlkq 97 14 variation variation NN cord-302316-raf5rlkq 97 15 data datum NNS cord-302316-raf5rlkq 97 16 for for IN cord-302316-raf5rlkq 97 17 these these DT cord-302316-raf5rlkq 97 18 children child NNS cord-302316-raf5rlkq 97 19 . . . cord-302316-raf5rlkq 98 1 They -PRON- PRP cord-302316-raf5rlkq 98 2 identified identify VBD cord-302316-raf5rlkq 98 3 a a DT cord-302316-raf5rlkq 98 4 variant variant JJ cord-302316-raf5rlkq 98 5 locus locus NN cord-302316-raf5rlkq 98 6 downstream downstream RB cord-302316-raf5rlkq 98 7 of of IN cord-302316-raf5rlkq 98 8 the the DT cord-302316-raf5rlkq 98 9 transcription transcription NN cord-302316-raf5rlkq 98 10 start start NN cord-302316-raf5rlkq 98 11 site site NN cord-302316-raf5rlkq 98 12 of of IN cord-302316-raf5rlkq 98 13 the the DT cord-302316-raf5rlkq 98 14 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 98 15 gene gene NN cord-302316-raf5rlkq 98 16 which which WDT cord-302316-raf5rlkq 98 17 was be VBD cord-302316-raf5rlkq 98 18 associated associate VBN cord-302316-raf5rlkq 98 19 with with IN cord-302316-raf5rlkq 98 20 a a DT cord-302316-raf5rlkq 98 21 large large JJ cord-302316-raf5rlkq 98 22 decrease decrease NN cord-302316-raf5rlkq 98 23 in in IN cord-302316-raf5rlkq 98 24 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 98 25 expression expression NN cord-302316-raf5rlkq 98 26 . . . cord-302316-raf5rlkq 99 1 They -PRON- PRP cord-302316-raf5rlkq 99 2 also also RB cord-302316-raf5rlkq 99 3 found find VBD cord-302316-raf5rlkq 99 4 variants variant NNS cord-302316-raf5rlkq 99 5 that that WDT cord-302316-raf5rlkq 99 6 were be VBD cord-302316-raf5rlkq 99 7 associated associate VBN cord-302316-raf5rlkq 99 8 with with IN cord-302316-raf5rlkq 99 9 increased increase VBN cord-302316-raf5rlkq 99 10 or or CC cord-302316-raf5rlkq 99 11 decreased decrease VBD cord-302316-raf5rlkq 99 12 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 99 13 expression expression NN cord-302316-raf5rlkq 99 14 . . . cord-302316-raf5rlkq 100 1 The the DT cord-302316-raf5rlkq 100 2 distribution distribution NN cord-302316-raf5rlkq 100 3 of of IN cord-302316-raf5rlkq 100 4 these these DT cord-302316-raf5rlkq 100 5 variants variant NNS cord-302316-raf5rlkq 100 6 showed show VBD cord-302316-raf5rlkq 100 7 clear clear JJ cord-302316-raf5rlkq 100 8 differences difference NNS cord-302316-raf5rlkq 100 9 in in IN cord-302316-raf5rlkq 100 10 diverse diverse JJ cord-302316-raf5rlkq 100 11 populations population NNS cord-302316-raf5rlkq 100 12 worldwide worldwide RB cord-302316-raf5rlkq 100 13 . . . cord-302316-raf5rlkq 101 1 It -PRON- PRP cord-302316-raf5rlkq 101 2 will will MD cord-302316-raf5rlkq 101 3 be be VB cord-302316-raf5rlkq 101 4 interesting interesting JJ cord-302316-raf5rlkq 101 5 to to TO cord-302316-raf5rlkq 101 6 study study VB cord-302316-raf5rlkq 101 7 whether whether IN cord-302316-raf5rlkq 101 8 distinct distinct JJ cord-302316-raf5rlkq 101 9 expression expression NN cord-302316-raf5rlkq 101 10 pattern pattern NN cord-302316-raf5rlkq 101 11 and and CC cord-302316-raf5rlkq 101 12 the the DT cord-302316-raf5rlkq 101 13 observed observed JJ cord-302316-raf5rlkq 101 14 genetic genetic JJ cord-302316-raf5rlkq 101 15 variants variant NNS cord-302316-raf5rlkq 101 16 explain explain VBP cord-302316-raf5rlkq 101 17 the the DT cord-302316-raf5rlkq 101 18 strikingly strikingly RB cord-302316-raf5rlkq 101 19 different different JJ cord-302316-raf5rlkq 101 20 clinical clinical JJ cord-302316-raf5rlkq 101 21 symptomatology symptomatology NN cord-302316-raf5rlkq 101 22 between between IN cord-302316-raf5rlkq 101 23 individuals individual NNS cord-302316-raf5rlkq 101 24 and and CC cord-302316-raf5rlkq 101 25 whether whether IN cord-302316-raf5rlkq 101 26 these these DT cord-302316-raf5rlkq 101 27 genetic genetic JJ cord-302316-raf5rlkq 101 28 markers marker NNS cord-302316-raf5rlkq 101 29 can can MD cord-302316-raf5rlkq 101 30 explain explain VB cord-302316-raf5rlkq 101 31 geographical geographical JJ cord-302316-raf5rlkq 101 32 differences difference NNS cord-302316-raf5rlkq 101 33 in in IN cord-302316-raf5rlkq 101 34 the the DT cord-302316-raf5rlkq 101 35 worldwide worldwide JJ cord-302316-raf5rlkq 101 36 prevalence prevalence NN cord-302316-raf5rlkq 101 37 of of IN cord-302316-raf5rlkq 101 38 the the DT cord-302316-raf5rlkq 101 39 pandemic pandemic NN cord-302316-raf5rlkq 102 1 ( ( -LRB- cord-302316-raf5rlkq 102 2 Sajuthi Sajuthi NNP cord-302316-raf5rlkq 102 3 et et NNP cord-302316-raf5rlkq 102 4 al al NNP cord-302316-raf5rlkq 102 5 . . NNP cord-302316-raf5rlkq 102 6 , , , cord-302316-raf5rlkq 102 7 2020 2020 CD cord-302316-raf5rlkq 102 8 ) ) -RRB- cord-302316-raf5rlkq 102 9 . . . cord-302316-raf5rlkq 103 1 Data datum NNS cord-302316-raf5rlkq 103 2 on on IN cord-302316-raf5rlkq 103 3 the the DT cord-302316-raf5rlkq 103 4 tissue tissue NN cord-302316-raf5rlkq 103 5 tropism tropism NN cord-302316-raf5rlkq 103 6 of of IN cord-302316-raf5rlkq 103 7 SARS SARS NNP cord-302316-raf5rlkq 103 8 - - HYPH cord-302316-raf5rlkq 103 9 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 103 10 are be VBP cord-302316-raf5rlkq 103 11 important important JJ cord-302316-raf5rlkq 103 12 in in IN cord-302316-raf5rlkq 103 13 order order NN cord-302316-raf5rlkq 103 14 to to TO cord-302316-raf5rlkq 103 15 understand understand VB cord-302316-raf5rlkq 103 16 the the DT cord-302316-raf5rlkq 103 17 clinical clinical JJ cord-302316-raf5rlkq 103 18 aspects aspect NNS cord-302316-raf5rlkq 103 19 of of IN cord-302316-raf5rlkq 103 20 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 103 21 . . . cord-302316-raf5rlkq 104 1 While while IN cord-302316-raf5rlkq 104 2 both both DT cord-302316-raf5rlkq 104 3 SARS SARS NNP cord-302316-raf5rlkq 104 4 - - HYPH cord-302316-raf5rlkq 104 5 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 104 6 and and CC cord-302316-raf5rlkq 104 7 SARS SARS NNP cord-302316-raf5rlkq 104 8 - - HYPH cord-302316-raf5rlkq 104 9 CoV CoV NNP cord-302316-raf5rlkq 104 10 ( ( -LRB- cord-302316-raf5rlkq 104 11 the the DT cord-302316-raf5rlkq 104 12 coronavirus coronavirus NN cord-302316-raf5rlkq 104 13 associated associate VBN cord-302316-raf5rlkq 104 14 with with IN cord-302316-raf5rlkq 104 15 the the DT cord-302316-raf5rlkq 104 16 2002 2002 CD cord-302316-raf5rlkq 104 17 SARS SARS NNP cord-302316-raf5rlkq 104 18 epidemic epidemic NN cord-302316-raf5rlkq 104 19 ) ) -RRB- cord-302316-raf5rlkq 104 20 use use VBP cord-302316-raf5rlkq 104 21 the the DT cord-302316-raf5rlkq 104 22 same same JJ cord-302316-raf5rlkq 104 23 cellular cellular JJ cord-302316-raf5rlkq 104 24 receptor receptor NN cord-302316-raf5rlkq 104 25 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 104 26 , , , cord-302316-raf5rlkq 104 27 SARS SARS NNP cord-302316-raf5rlkq 104 28 - - HYPH cord-302316-raf5rlkq 104 29 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 104 30 causes cause VBZ cord-302316-raf5rlkq 104 31 much much RB cord-302316-raf5rlkq 104 32 less less JJR cord-302316-raf5rlkq 104 33 diarrhoea diarrhoea NN cord-302316-raf5rlkq 104 34 ( ( -LRB- cord-302316-raf5rlkq 104 35 10 10 CD cord-302316-raf5rlkq 104 36 % % NN cord-302316-raf5rlkq 104 37 of of IN cord-302316-raf5rlkq 104 38 patients patient NNS cord-302316-raf5rlkq 104 39 ) ) -RRB- cord-302316-raf5rlkq 104 40 than than IN cord-302316-raf5rlkq 104 41 SARS SARS NNP cord-302316-raf5rlkq 104 42 - - HYPH cord-302316-raf5rlkq 104 43 CoV CoV NNP cord-302316-raf5rlkq 104 44 , , , cord-302316-raf5rlkq 104 45 but but CC cord-302316-raf5rlkq 104 46 it -PRON- PRP cord-302316-raf5rlkq 104 47 has have VBZ cord-302316-raf5rlkq 104 48 more more RBR cord-302316-raf5rlkq 104 49 neurological neurological JJ cord-302316-raf5rlkq 104 50 manifestations manifestation NNS cord-302316-raf5rlkq 104 51 ( ( -LRB- cord-302316-raf5rlkq 104 52 confusion confusion NN cord-302316-raf5rlkq 104 53 , , , cord-302316-raf5rlkq 104 54 9 9 CD cord-302316-raf5rlkq 104 55 % % NN cord-302316-raf5rlkq 104 56 ) ) -RRB- cord-302316-raf5rlkq 104 57 . . . cord-302316-raf5rlkq 105 1 Such such JJ cord-302316-raf5rlkq 105 2 distinct distinct JJ cord-302316-raf5rlkq 105 3 dissimilarity dissimilarity NN cord-302316-raf5rlkq 105 4 in in IN cord-302316-raf5rlkq 105 5 organ organ NN cord-302316-raf5rlkq 105 6 tropism tropism NN cord-302316-raf5rlkq 105 7 was be VBD cord-302316-raf5rlkq 105 8 also also RB cord-302316-raf5rlkq 105 9 reflected reflect VBN cord-302316-raf5rlkq 105 10 in in IN cord-302316-raf5rlkq 105 11 the the DT cord-302316-raf5rlkq 105 12 differences difference NNS cord-302316-raf5rlkq 105 13 in in IN cord-302316-raf5rlkq 105 14 their -PRON- PRP$ cord-302316-raf5rlkq 105 15 capacity capacity NN cord-302316-raf5rlkq 105 16 to to TO cord-302316-raf5rlkq 105 17 infect infect VB cord-302316-raf5rlkq 105 18 pulmonary pulmonary JJ cord-302316-raf5rlkq 105 19 , , , cord-302316-raf5rlkq 105 20 intestinal intestinal JJ cord-302316-raf5rlkq 105 21 and and CC cord-302316-raf5rlkq 105 22 neurological neurological JJ cord-302316-raf5rlkq 105 23 cell cell NN cord-302316-raf5rlkq 105 24 lines line NNS cord-302316-raf5rlkq 105 25 . . . cord-302316-raf5rlkq 106 1 Ex Ex NNP cord-302316-raf5rlkq 106 2 vivo vivo NN cord-302316-raf5rlkq 106 3 studies study NNS cord-302316-raf5rlkq 106 4 with with IN cord-302316-raf5rlkq 106 5 human human JJ cord-302316-raf5rlkq 106 6 tissues tissue NNS cord-302316-raf5rlkq 106 7 obtained obtain VBN cord-302316-raf5rlkq 106 8 during during IN cord-302316-raf5rlkq 106 9 surgery surgery NN cord-302316-raf5rlkq 106 10 demonstrated demonstrate VBD cord-302316-raf5rlkq 106 11 that that IN cord-302316-raf5rlkq 106 12 SARS SARS NNP cord-302316-raf5rlkq 106 13 - - HYPH cord-302316-raf5rlkq 106 14 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 106 15 infects infect VBZ cord-302316-raf5rlkq 106 16 ciliated ciliated JJ cord-302316-raf5rlkq 106 17 and and CC cord-302316-raf5rlkq 106 18 mucus mucus NN cord-302316-raf5rlkq 106 19 - - HYPH cord-302316-raf5rlkq 106 20 producing produce VBG cord-302316-raf5rlkq 106 21 goblet goblet NN cord-302316-raf5rlkq 106 22 cells cell NNS cord-302316-raf5rlkq 106 23 and and CC cord-302316-raf5rlkq 106 24 club club NN cord-302316-raf5rlkq 106 25 cells cell NNS cord-302316-raf5rlkq 106 26 in in IN cord-302316-raf5rlkq 106 27 the the DT cord-302316-raf5rlkq 106 28 bronchi bronchi NN cord-302316-raf5rlkq 106 29 , , , cord-302316-raf5rlkq 106 30 pneumocytes pneumocyte NNS cord-302316-raf5rlkq 106 31 in in IN cord-302316-raf5rlkq 106 32 the the DT cord-302316-raf5rlkq 106 33 lung lung NN cord-302316-raf5rlkq 106 34 and and CC cord-302316-raf5rlkq 106 35 the the DT cord-302316-raf5rlkq 106 36 conjunctiva conjunctiva NN cord-302316-raf5rlkq 106 37 of of IN cord-302316-raf5rlkq 106 38 eyes eye NNS cord-302316-raf5rlkq 107 1 ( ( -LRB- cord-302316-raf5rlkq 107 2 Hui Hui NNP cord-302316-raf5rlkq 107 3 et et NNP cord-302316-raf5rlkq 107 4 al al NNP cord-302316-raf5rlkq 107 5 . . NNP cord-302316-raf5rlkq 107 6 , , , cord-302316-raf5rlkq 107 7 2020 2020 CD cord-302316-raf5rlkq 107 8 ) ) -RRB- cord-302316-raf5rlkq 107 9 . . . cord-302316-raf5rlkq 108 1 Organoids Organoids NNP cord-302316-raf5rlkq 108 2 , , , cord-302316-raf5rlkq 108 3 3-D 3-d JJ cord-302316-raf5rlkq 108 4 cell cell NN cord-302316-raf5rlkq 108 5 structures structure NNS cord-302316-raf5rlkq 108 6 grown grow VBN cord-302316-raf5rlkq 108 7 from from IN cord-302316-raf5rlkq 108 8 stem stem NN cord-302316-raf5rlkq 108 9 cells cell NNS cord-302316-raf5rlkq 108 10 that that WDT cord-302316-raf5rlkq 108 11 recapitulate recapitulate VBP cord-302316-raf5rlkq 108 12 key key JJ cord-302316-raf5rlkq 108 13 aspects aspect NNS cord-302316-raf5rlkq 108 14 of of IN cord-302316-raf5rlkq 108 15 the the DT cord-302316-raf5rlkq 108 16 organs organ NNS cord-302316-raf5rlkq 108 17 , , , cord-302316-raf5rlkq 108 18 were be VBD cord-302316-raf5rlkq 108 19 obtained obtain VBN cord-302316-raf5rlkq 108 20 from from IN cord-302316-raf5rlkq 108 21 human human JJ cord-302316-raf5rlkq 108 22 small small JJ cord-302316-raf5rlkq 108 23 intestine intestine NN cord-302316-raf5rlkq 108 24 and and CC cord-302316-raf5rlkq 108 25 could could MD cord-302316-raf5rlkq 108 26 also also RB cord-302316-raf5rlkq 108 27 be be VB cord-302316-raf5rlkq 108 28 successfully successfully RB cord-302316-raf5rlkq 108 29 infected infect VBN cord-302316-raf5rlkq 108 30 with with IN cord-302316-raf5rlkq 108 31 SARS SARS NNP cord-302316-raf5rlkq 108 32 - - HYPH cord-302316-raf5rlkq 108 33 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 108 34 . . . cord-302316-raf5rlkq 109 1 Enterocyte Enterocyte NNP cord-302316-raf5rlkq 109 2 progenitors progenitor NNS cord-302316-raf5rlkq 109 3 were be VBD cord-302316-raf5rlkq 109 4 the the DT cord-302316-raf5rlkq 109 5 primary primary JJ cord-302316-raf5rlkq 109 6 viral viral JJ cord-302316-raf5rlkq 109 7 target target NN cord-302316-raf5rlkq 109 8 cells cell NNS cord-302316-raf5rlkq 109 9 , , , cord-302316-raf5rlkq 109 10 but but CC cord-302316-raf5rlkq 109 11 also also RB cord-302316-raf5rlkq 109 12 differentiated differentiate VBN cord-302316-raf5rlkq 109 13 enterocytes enterocyte NNS cord-302316-raf5rlkq 109 14 were be VBD cord-302316-raf5rlkq 109 15 infected infect VBN cord-302316-raf5rlkq 109 16 and and CC cord-302316-raf5rlkq 109 17 no no DT cord-302316-raf5rlkq 109 18 other other JJ cord-302316-raf5rlkq 109 19 intestinal intestinal JJ cord-302316-raf5rlkq 109 20 cell cell NN cord-302316-raf5rlkq 109 21 types type NNS cord-302316-raf5rlkq 109 22 . . . cord-302316-raf5rlkq 110 1 The the DT cord-302316-raf5rlkq 110 2 viral viral JJ cord-302316-raf5rlkq 110 3 receptor receptor NN cord-302316-raf5rlkq 110 4 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 110 5 was be VBD cord-302316-raf5rlkq 110 6 abundantly abundantly RB cord-302316-raf5rlkq 110 7 expressed express VBN cord-302316-raf5rlkq 110 8 on on IN cord-302316-raf5rlkq 110 9 the the DT cord-302316-raf5rlkq 110 10 brush brush NN cord-302316-raf5rlkq 110 11 border border NN cord-302316-raf5rlkq 110 12 membranes membrane NNS cord-302316-raf5rlkq 110 13 of of IN cord-302316-raf5rlkq 110 14 enterocytes enterocyte NNS cord-302316-raf5rlkq 110 15 . . . cord-302316-raf5rlkq 111 1 Viral viral JJ cord-302316-raf5rlkq 111 2 replication replication NN cord-302316-raf5rlkq 111 3 occurred occur VBD cord-302316-raf5rlkq 111 4 in in IN cord-302316-raf5rlkq 111 5 intracellular intracellular JJ cord-302316-raf5rlkq 111 6 ' ' `` cord-302316-raf5rlkq 111 7 viral viral JJ cord-302316-raf5rlkq 111 8 factories factory NNS cord-302316-raf5rlkq 111 9 ' ' POS cord-302316-raf5rlkq 111 10 surrounded surround VBN cord-302316-raf5rlkq 111 11 by by IN cord-302316-raf5rlkq 111 12 a a DT cord-302316-raf5rlkq 111 13 double double JJ cord-302316-raf5rlkq 111 14 membrane membrane NN cord-302316-raf5rlkq 111 15 . . . cord-302316-raf5rlkq 112 1 Viruses virus NNS cord-302316-raf5rlkq 112 2 were be VBD cord-302316-raf5rlkq 112 3 mainly mainly RB cord-302316-raf5rlkq 112 4 released release VBN cord-302316-raf5rlkq 112 5 apically apically RB cord-302316-raf5rlkq 112 6 from from IN cord-302316-raf5rlkq 112 7 the the DT cord-302316-raf5rlkq 112 8 enterocytes enterocyte NNS cord-302316-raf5rlkq 112 9 . . . cord-302316-raf5rlkq 113 1 SARS SARS NNP cord-302316-raf5rlkq 113 2 - - HYPH cord-302316-raf5rlkq 113 3 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 113 4 induced induce VBD cord-302316-raf5rlkq 113 5 the the DT cord-302316-raf5rlkq 113 6 transcription transcription NN cord-302316-raf5rlkq 113 7 of of IN cord-302316-raf5rlkq 113 8 cytokines cytokine NNS cord-302316-raf5rlkq 113 9 and and CC cord-302316-raf5rlkq 113 10 interferon interferon NN cord-302316-raf5rlkq 113 11 - - HYPH cord-302316-raf5rlkq 113 12 stimulated stimulate VBN cord-302316-raf5rlkq 113 13 genes gene NNS cord-302316-raf5rlkq 113 14 in in IN cord-302316-raf5rlkq 113 15 gut gut NN cord-302316-raf5rlkq 113 16 organoids organoid NNS cord-302316-raf5rlkq 113 17 . . . cord-302316-raf5rlkq 114 1 An an DT cord-302316-raf5rlkq 114 2 impressive impressive JJ cord-302316-raf5rlkq 114 3 approach approach NN cord-302316-raf5rlkq 114 4 to to IN cord-302316-raf5rlkq 114 5 tissue tissue NN cord-302316-raf5rlkq 114 6 tropism tropism NN cord-302316-raf5rlkq 114 7 was be VBD cord-302316-raf5rlkq 114 8 published publish VBN cord-302316-raf5rlkq 114 9 by by IN cord-302316-raf5rlkq 114 10 the the DT cord-302316-raf5rlkq 114 11 US US NNP cord-302316-raf5rlkq 114 12 Lung Lung NNP cord-302316-raf5rlkq 114 13 Biological Biological NNP cord-302316-raf5rlkq 114 14 Network Network NNP cord-302316-raf5rlkq 114 15 . . . cord-302316-raf5rlkq 115 1 The the DT cord-302316-raf5rlkq 115 2 consortium consortium NN cord-302316-raf5rlkq 115 3 used use VBD cord-302316-raf5rlkq 115 4 large large JJ cord-302316-raf5rlkq 115 5 single single JJ cord-302316-raf5rlkq 115 6 - - HYPH cord-302316-raf5rlkq 115 7 cell cell NN cord-302316-raf5rlkq 115 8 RNA rna NN cord-302316-raf5rlkq 115 9 sequencing sequencing NN cord-302316-raf5rlkq 115 10 ( ( -LRB- cord-302316-raf5rlkq 115 11 scRNAseq scRNAseq NNP cord-302316-raf5rlkq 115 12 ) ) -RRB- cord-302316-raf5rlkq 115 13 data datum NNS cord-302316-raf5rlkq 115 14 sets set NNS cord-302316-raf5rlkq 115 15 from from IN cord-302316-raf5rlkq 115 16 primates primate NNS cord-302316-raf5rlkq 115 17 and and CC cord-302316-raf5rlkq 115 18 humans human NNS cord-302316-raf5rlkq 115 19 , , , cord-302316-raf5rlkq 115 20 asking ask VBG cord-302316-raf5rlkq 115 21 which which WDT cord-302316-raf5rlkq 115 22 cellular cellular JJ cord-302316-raf5rlkq 115 23 subsets subset NNS cord-302316-raf5rlkq 115 24 coexpressed coexpresse VBD cord-302316-raf5rlkq 115 25 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 115 26 and and CC cord-302316-raf5rlkq 115 27 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 115 28 . . . cord-302316-raf5rlkq 116 1 Doublepositive Doublepositive NNP cord-302316-raf5rlkq 116 2 cells cell NNS cord-302316-raf5rlkq 116 3 are be VBP cord-302316-raf5rlkq 116 4 the the DT cord-302316-raf5rlkq 116 5 likely likely JJ cord-302316-raf5rlkq 116 6 support support NN cord-302316-raf5rlkq 116 7 for for IN cord-302316-raf5rlkq 116 8 in in IN cord-302316-raf5rlkq 116 9 vivo vivo FW cord-302316-raf5rlkq 116 10 viral viral JJ cord-302316-raf5rlkq 116 11 replication replication NN cord-302316-raf5rlkq 116 12 . . . cord-302316-raf5rlkq 117 1 Seventeen seventeen CD cord-302316-raf5rlkq 117 2 cell cell NN cord-302316-raf5rlkq 117 3 types type NNS cord-302316-raf5rlkq 117 4 were be VBD cord-302316-raf5rlkq 117 5 distinguished distinguish VBN cord-302316-raf5rlkq 117 6 in in IN cord-302316-raf5rlkq 117 7 the the DT cord-302316-raf5rlkq 117 8 lungs lung NNS cord-302316-raf5rlkq 117 9 of of IN cord-302316-raf5rlkq 117 10 rhesus rhesu NNS cord-302316-raf5rlkq 117 11 monkeys monkey NNS cord-302316-raf5rlkq 117 12 , , , cord-302316-raf5rlkq 117 13 but but CC cord-302316-raf5rlkq 117 14 only only JJ cord-302316-raf5rlkq 117 15 type type NN cord-302316-raf5rlkq 117 16 II II NNP cord-302316-raf5rlkq 117 17 pneumocytes pneumocyte NNS cord-302316-raf5rlkq 117 18 expressed express VBD cord-302316-raf5rlkq 117 19 both both DT cord-302316-raf5rlkq 117 20 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 117 21 and and CC cord-302316-raf5rlkq 117 22 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 117 23 . . . cord-302316-raf5rlkq 118 1 In in IN cord-302316-raf5rlkq 118 2 lung lung NN cord-302316-raf5rlkq 118 3 resection resection NN cord-302316-raf5rlkq 118 4 material material NN cord-302316-raf5rlkq 118 5 from from IN cord-302316-raf5rlkq 118 6 humans human NNS cord-302316-raf5rlkq 118 7 , , , cord-302316-raf5rlkq 118 8 type type NN cord-302316-raf5rlkq 118 9 II II NNP cord-302316-raf5rlkq 118 10 pneumocytes pneumocyte NNS cord-302316-raf5rlkq 118 11 and and CC cord-302316-raf5rlkq 118 12 ciliated ciliated JJ cord-302316-raf5rlkq 118 13 cells cell NNS cord-302316-raf5rlkq 118 14 showed show VBD cord-302316-raf5rlkq 118 15 this this DT cord-302316-raf5rlkq 118 16 double double JJ cord-302316-raf5rlkq 118 17 expression expression NN cord-302316-raf5rlkq 118 18 . . . cord-302316-raf5rlkq 119 1 A a DT cord-302316-raf5rlkq 119 2 striking striking JJ cord-302316-raf5rlkq 119 3 observation observation NN cord-302316-raf5rlkq 119 4 both both CC cord-302316-raf5rlkq 119 5 in in IN cord-302316-raf5rlkq 119 6 rhesus rhesus NNP cord-302316-raf5rlkq 119 7 monkey monkey NN cord-302316-raf5rlkq 119 8 and and CC cord-302316-raf5rlkq 119 9 in in IN cord-302316-raf5rlkq 119 10 humans human NNS cord-302316-raf5rlkq 119 11 was be VBD cord-302316-raf5rlkq 119 12 that that IN cord-302316-raf5rlkq 119 13 interferon interferon NN cord-302316-raf5rlkq 119 14 - - HYPH cord-302316-raf5rlkq 119 15 induced induce VBN cord-302316-raf5rlkq 119 16 genes gene NNS cord-302316-raf5rlkq 119 17 were be VBD cord-302316-raf5rlkq 119 18 upregulated upregulate VBN cord-302316-raf5rlkq 119 19 in in IN cord-302316-raf5rlkq 119 20 these these DT cord-302316-raf5rlkq 119 21 double double JJ cord-302316-raf5rlkq 119 22 - - HYPH cord-302316-raf5rlkq 119 23 positive positive JJ cord-302316-raf5rlkq 119 24 cells cell NNS cord-302316-raf5rlkq 119 25 . . . cord-302316-raf5rlkq 120 1 Absorptive absorptive JJ cord-302316-raf5rlkq 120 2 enterocytes enterocyte NNS cord-302316-raf5rlkq 120 3 from from IN cord-302316-raf5rlkq 120 4 the the DT cord-302316-raf5rlkq 120 5 ileum ileum NN cord-302316-raf5rlkq 120 6 and and CC cord-302316-raf5rlkq 120 7 jejunumboth jejunumboth JJ cord-302316-raf5rlkq 120 8 from from IN cord-302316-raf5rlkq 120 9 monkeys monkey NNS cord-302316-raf5rlkq 120 10 and and CC cord-302316-raf5rlkq 120 11 from from IN cord-302316-raf5rlkq 120 12 the the DT cord-302316-raf5rlkq 120 13 biopsies biopsy NNS cord-302316-raf5rlkq 120 14 of of IN cord-302316-raf5rlkq 120 15 childrencoexpressed childrencoexpresse VBN cord-302316-raf5rlkq 120 16 both both DT cord-302316-raf5rlkq 120 17 genes gene NNS cord-302316-raf5rlkq 120 18 , , , cord-302316-raf5rlkq 120 19 explaining explain VBG cord-302316-raf5rlkq 120 20 the the DT cord-302316-raf5rlkq 120 21 viral viral JJ cord-302316-raf5rlkq 120 22 tropism tropism NN cord-302316-raf5rlkq 120 23 in in IN cord-302316-raf5rlkq 120 24 the the DT cord-302316-raf5rlkq 120 25 gut gut NN cord-302316-raf5rlkq 120 26 . . . cord-302316-raf5rlkq 121 1 In in IN cord-302316-raf5rlkq 121 2 the the DT cord-302316-raf5rlkq 121 3 upper upper JJ cord-302316-raf5rlkq 121 4 respiratory respiratory JJ cord-302316-raf5rlkq 121 5 tract tract NN cord-302316-raf5rlkq 121 6 of of IN cord-302316-raf5rlkq 121 7 humans human NNS cord-302316-raf5rlkq 121 8 , , , cord-302316-raf5rlkq 121 9 apical apical JJ cord-302316-raf5rlkq 121 10 and and CC cord-302316-raf5rlkq 121 11 ciliated ciliated JJ cord-302316-raf5rlkq 121 12 cells cell NNS cord-302316-raf5rlkq 121 13 of of IN cord-302316-raf5rlkq 121 14 the the DT cord-302316-raf5rlkq 121 15 ethmoid ethmoid NNP cord-302316-raf5rlkq 121 16 sinus sinus NN cord-302316-raf5rlkq 121 17 and and CC cord-302316-raf5rlkq 121 18 secretory secretory JJ cord-302316-raf5rlkq 121 19 goblet goblet NN cord-302316-raf5rlkq 121 20 cells cell NNS cord-302316-raf5rlkq 121 21 of of IN cord-302316-raf5rlkq 121 22 the the DT cord-302316-raf5rlkq 121 23 inferior inferior JJ cord-302316-raf5rlkq 121 24 turbinate turbinate NN cord-302316-raf5rlkq 121 25 of of IN cord-302316-raf5rlkq 121 26 the the DT cord-302316-raf5rlkq 121 27 nose nose NN cord-302316-raf5rlkq 121 28 showed show VBD cord-302316-raf5rlkq 121 29 this this DT cord-302316-raf5rlkq 121 30 doubly doubly RB cord-302316-raf5rlkq 121 31 positive positive JJ cord-302316-raf5rlkq 121 32 expression expression NN cord-302316-raf5rlkq 121 33 pattern pattern NN cord-302316-raf5rlkq 121 34 , , , cord-302316-raf5rlkq 121 35 and and CC cord-302316-raf5rlkq 121 36 , , , cord-302316-raf5rlkq 121 37 again again RB cord-302316-raf5rlkq 121 38 , , , cord-302316-raf5rlkq 121 39 showed show VBD cord-302316-raf5rlkq 121 40 a a DT cord-302316-raf5rlkq 121 41 concomitant concomitant JJ cord-302316-raf5rlkq 121 42 upregulation upregulation NN cord-302316-raf5rlkq 121 43 of of IN cord-302316-raf5rlkq 121 44 an an DT cord-302316-raf5rlkq 121 45 interferon interferon NN cord-302316-raf5rlkq 121 46 alpha alpha NN cord-302316-raf5rlkq 121 47 - - HYPH cord-302316-raf5rlkq 121 48 stimulated stimulate VBN cord-302316-raf5rlkq 121 49 gene gene NN cord-302316-raf5rlkq 121 50 set set NN cord-302316-raf5rlkq 121 51 . . . cord-302316-raf5rlkq 122 1 In in IN cord-302316-raf5rlkq 122 2 primary primary JJ cord-302316-raf5rlkq 122 3 human human JJ cord-302316-raf5rlkq 122 4 upper upper JJ cord-302316-raf5rlkq 122 5 airway airway NN cord-302316-raf5rlkq 122 6 epithelial epithelial JJ cord-302316-raf5rlkq 122 7 cells cell NNS cord-302316-raf5rlkq 122 8 , , , cord-302316-raf5rlkq 122 9 the the DT cord-302316-raf5rlkq 122 10 authors author NNS cord-302316-raf5rlkq 122 11 tested test VBD cord-302316-raf5rlkq 122 12 whether whether IN cord-302316-raf5rlkq 122 13 interferon interferon NN cord-302316-raf5rlkq 122 14 plays play VBZ cord-302316-raf5rlkq 122 15 an an DT cord-302316-raf5rlkq 122 16 active active JJ cord-302316-raf5rlkq 122 17 role role NN cord-302316-raf5rlkq 122 18 in in IN cord-302316-raf5rlkq 122 19 upregulating upregulate VBG cord-302316-raf5rlkq 122 20 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 122 21 expression expression NN cord-302316-raf5rlkq 122 22 . . . cord-302316-raf5rlkq 123 1 This this DT cord-302316-raf5rlkq 123 2 was be VBD cord-302316-raf5rlkq 123 3 indeed indeed RB cord-302316-raf5rlkq 123 4 the the DT cord-302316-raf5rlkq 123 5 case case NN cord-302316-raf5rlkq 123 6 for for IN cord-302316-raf5rlkq 123 7 interferon interferon NNP cord-302316-raf5rlkq 123 8 alpha alpha NN cord-302316-raf5rlkq 123 9 , , , cord-302316-raf5rlkq 123 10 but but CC cord-302316-raf5rlkq 123 11 not not RB cord-302316-raf5rlkq 123 12 for for IN cord-302316-raf5rlkq 123 13 interferon interferon NN cord-302316-raf5rlkq 123 14 gamma gamma NN cord-302316-raf5rlkq 123 15 . . . cord-302316-raf5rlkq 124 1 When when WRB cord-302316-raf5rlkq 124 2 screening screen VBG cord-302316-raf5rlkq 124 3 the the DT cord-302316-raf5rlkq 124 4 RNAseq RNAseq NNP cord-302316-raf5rlkq 124 5 database database NN cord-302316-raf5rlkq 124 6 , , , cord-302316-raf5rlkq 124 7 the the DT cord-302316-raf5rlkq 124 8 authors author NNS cord-302316-raf5rlkq 124 9 found find VBD cord-302316-raf5rlkq 124 10 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 124 11 upregulation upregulation NN cord-302316-raf5rlkq 124 12 in in IN cord-302316-raf5rlkq 124 13 human human JJ cord-302316-raf5rlkq 124 14 lung lung NN cord-302316-raf5rlkq 124 15 tissues tissue NNS cord-302316-raf5rlkq 124 16 infected infect VBN cord-302316-raf5rlkq 124 17 ex ex FW cord-302316-raf5rlkq 124 18 vivo vivo NN cord-302316-raf5rlkq 124 19 with with IN cord-302316-raf5rlkq 124 20 influenza influenza NN cord-302316-raf5rlkq 124 21 virus virus NN cord-302316-raf5rlkq 124 22 . . . cord-302316-raf5rlkq 125 1 These these DT cord-302316-raf5rlkq 125 2 observations observation NNS cord-302316-raf5rlkq 125 3 led lead VBD cord-302316-raf5rlkq 125 4 to to IN cord-302316-raf5rlkq 125 5 the the DT cord-302316-raf5rlkq 125 6 hypothesis hypothesis NN cord-302316-raf5rlkq 125 7 that that WDT cord-302316-raf5rlkq 125 8 coronaviruses coronaviruse NNS cord-302316-raf5rlkq 125 9 exploit exploit VBP cord-302316-raf5rlkq 125 10 the the DT cord-302316-raf5rlkq 125 11 antiviral antiviral JJ cord-302316-raf5rlkq 125 12 interferon interferon NN cord-302316-raf5rlkq 125 13 response response NN cord-302316-raf5rlkq 125 14 to to IN cord-302316-raf5rlkq 125 15 their -PRON- PRP$ cord-302316-raf5rlkq 125 16 advantage advantage NN cord-302316-raf5rlkq 125 17 by by IN cord-302316-raf5rlkq 125 18 increasing increase VBG cord-302316-raf5rlkq 125 19 the the DT cord-302316-raf5rlkq 125 20 expression expression NN cord-302316-raf5rlkq 125 21 of of IN cord-302316-raf5rlkq 125 22 their -PRON- PRP$ cord-302316-raf5rlkq 125 23 cell cell NN cord-302316-raf5rlkq 125 24 receptor receptor NN cord-302316-raf5rlkq 125 25 , , , cord-302316-raf5rlkq 125 26 allowing allow VBG cord-302316-raf5rlkq 125 27 a a DT cord-302316-raf5rlkq 125 28 greater great JJR cord-302316-raf5rlkq 125 29 number number NN cord-302316-raf5rlkq 125 30 of of IN cord-302316-raf5rlkq 125 31 cells cell NNS cord-302316-raf5rlkq 125 32 to to TO cord-302316-raf5rlkq 125 33 be be VB cord-302316-raf5rlkq 125 34 infected infect VBN cord-302316-raf5rlkq 125 35 . . . cord-302316-raf5rlkq 126 1 The the DT cord-302316-raf5rlkq 126 2 authors author NNS cord-302316-raf5rlkq 126 3 caution caution VBP cord-302316-raf5rlkq 126 4 against against IN cord-302316-raf5rlkq 126 5 the the DT cord-302316-raf5rlkq 126 6 use use NN cord-302316-raf5rlkq 126 7 of of IN cord-302316-raf5rlkq 126 8 interferon interferon NN cord-302316-raf5rlkq 126 9 alpha alpha NN cord-302316-raf5rlkq 126 10 in in IN cord-302316-raf5rlkq 126 11 clinical clinical JJ cord-302316-raf5rlkq 126 12 trials trial NNS cord-302316-raf5rlkq 126 13 with with IN cord-302316-raf5rlkq 126 14 COVID-19 covid-19 JJ cord-302316-raf5rlkq 126 15 patients patient NNS cord-302316-raf5rlkq 126 16 ( ( -LRB- cord-302316-raf5rlkq 126 17 Ziegler Ziegler NNP cord-302316-raf5rlkq 126 18 et et NNP cord-302316-raf5rlkq 126 19 al al NNP cord-302316-raf5rlkq 126 20 . . NNP cord-302316-raf5rlkq 126 21 , , , cord-302316-raf5rlkq 126 22 2020 2020 CD cord-302316-raf5rlkq 126 23 ) ) -RRB- cord-302316-raf5rlkq 126 24 . . . cord-302316-raf5rlkq 127 1 Testing testing NN cord-302316-raf5rlkq 127 2 animals animal NNS cord-302316-raf5rlkq 128 1 SARS SARS NNP cord-302316-raf5rlkq 128 2 - - HYPH cord-302316-raf5rlkq 128 3 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 128 4 is be VBZ cord-302316-raf5rlkq 128 5 suspected suspect VBN cord-302316-raf5rlkq 128 6 to to TO cord-302316-raf5rlkq 128 7 have have VB cord-302316-raf5rlkq 128 8 originated originate VBN cord-302316-raf5rlkq 128 9 from from IN cord-302316-raf5rlkq 128 10 bats bat NNS cord-302316-raf5rlkq 128 11 , , , cord-302316-raf5rlkq 128 12 but but CC cord-302316-raf5rlkq 128 13 the the DT cord-302316-raf5rlkq 128 14 intermediate intermediate JJ cord-302316-raf5rlkq 128 15 host host NN cord-302316-raf5rlkq 128 16 for for IN cord-302316-raf5rlkq 128 17 the the DT cord-302316-raf5rlkq 128 18 transfer transfer NN cord-302316-raf5rlkq 128 19 to to IN cord-302316-raf5rlkq 128 20 humans human NNS cord-302316-raf5rlkq 128 21 is be VBZ cord-302316-raf5rlkq 128 22 currently currently RB cord-302316-raf5rlkq 128 23 unknown unknown JJ cord-302316-raf5rlkq 128 24 . . . cord-302316-raf5rlkq 129 1 Chinese chinese JJ cord-302316-raf5rlkq 129 2 scientists scientist NNS cord-302316-raf5rlkq 129 3 inoculated inoculate VBD cord-302316-raf5rlkq 129 4 a a DT cord-302316-raf5rlkq 129 5 number number NN cord-302316-raf5rlkq 129 6 of of IN cord-302316-raf5rlkq 129 7 animals animal NNS cord-302316-raf5rlkq 129 8 with with IN cord-302316-raf5rlkq 129 9 both both CC cord-302316-raf5rlkq 129 10 an an DT cord-302316-raf5rlkq 129 11 environmental environmental JJ cord-302316-raf5rlkq 129 12 virus virus NN cord-302316-raf5rlkq 129 13 isolate isolate VBP cord-302316-raf5rlkq 129 14 from from IN cord-302316-raf5rlkq 129 15 the the DT cord-302316-raf5rlkq 129 16 wet wet JJ cord-302316-raf5rlkq 129 17 food food NN cord-302316-raf5rlkq 129 18 market market NN cord-302316-raf5rlkq 129 19 in in IN cord-302316-raf5rlkq 129 20 Wuhan Wuhan NNP cord-302316-raf5rlkq 129 21 , , , cord-302316-raf5rlkq 129 22 from from IN cord-302316-raf5rlkq 129 23 where where WRB cord-302316-raf5rlkq 129 24 the the DT cord-302316-raf5rlkq 129 25 epidemic epidemic NN cord-302316-raf5rlkq 129 26 started start VBD cord-302316-raf5rlkq 129 27 , , , cord-302316-raf5rlkq 129 28 and and CC cord-302316-raf5rlkq 129 29 an an DT cord-302316-raf5rlkq 129 30 isolate isolate NN cord-302316-raf5rlkq 129 31 from from IN cord-302316-raf5rlkq 129 32 a a DT cord-302316-raf5rlkq 129 33 patient patient NN cord-302316-raf5rlkq 129 34 from from IN cord-302316-raf5rlkq 129 35 Wuhan Wuhan NNP cord-302316-raf5rlkq 129 36 early early RB cord-302316-raf5rlkq 129 37 in in IN cord-302316-raf5rlkq 129 38 the the DT cord-302316-raf5rlkq 129 39 epidemic epidemic NN cord-302316-raf5rlkq 129 40 . . . cord-302316-raf5rlkq 130 1 Ferrets ferret NNS cord-302316-raf5rlkq 130 2 have have VBP cord-302316-raf5rlkq 130 3 been be VBN cord-302316-raf5rlkq 130 4 infected infect VBN cord-302316-raf5rlkq 130 5 and and CC cord-302316-raf5rlkq 130 6 developed develop VBN cord-302316-raf5rlkq 130 7 an an DT cord-302316-raf5rlkq 130 8 upper upper JJ cord-302316-raf5rlkq 130 9 respiratory respiratory JJ cord-302316-raf5rlkq 130 10 tract tract NN cord-302316-raf5rlkq 130 11 infection infection NN cord-302316-raf5rlkq 130 12 with with IN cord-302316-raf5rlkq 130 13 fever fever NN cord-302316-raf5rlkq 130 14 . . . cord-302316-raf5rlkq 131 1 Outbred outbreed VBN cord-302316-raf5rlkq 131 2 domestic domestic JJ cord-302316-raf5rlkq 131 3 cats cat NNS cord-302316-raf5rlkq 131 4 have have VBP cord-302316-raf5rlkq 131 5 also also RB cord-302316-raf5rlkq 131 6 been be VBN cord-302316-raf5rlkq 131 7 infected infect VBN cord-302316-raf5rlkq 131 8 and and CC cord-302316-raf5rlkq 131 9 then then RB cord-302316-raf5rlkq 131 10 have have VBP cord-302316-raf5rlkq 131 11 developed develop VBN cord-302316-raf5rlkq 131 12 respiratory respiratory JJ cord-302316-raf5rlkq 131 13 tract tract NN cord-302316-raf5rlkq 131 14 symptoms symptom NNS cord-302316-raf5rlkq 131 15 and and CC cord-302316-raf5rlkq 131 16 specific specific JJ cord-302316-raf5rlkq 131 17 antibodies antibody NNS cord-302316-raf5rlkq 131 18 . . . cord-302316-raf5rlkq 132 1 Cats cat NNS cord-302316-raf5rlkq 132 2 can can MD cord-302316-raf5rlkq 132 3 transmit transmit VB cord-302316-raf5rlkq 132 4 infection infection NN cord-302316-raf5rlkq 132 5 via via IN cord-302316-raf5rlkq 132 6 the the DT cord-302316-raf5rlkq 132 7 airborne airborne JJ cord-302316-raf5rlkq 132 8 route route NN cord-302316-raf5rlkq 132 9 to to IN cord-302316-raf5rlkq 132 10 other other JJ cord-302316-raf5rlkq 132 11 cats cat NNS cord-302316-raf5rlkq 132 12 . . . cord-302316-raf5rlkq 133 1 Viral Viral NNP cord-302316-raf5rlkq 133 2 RNA RNA NNP cord-302316-raf5rlkq 133 3 , , , cord-302316-raf5rlkq 133 4 but but CC cord-302316-raf5rlkq 133 5 not not RB cord-302316-raf5rlkq 133 6 infectious infectious JJ cord-302316-raf5rlkq 133 7 virus virus NN cord-302316-raf5rlkq 133 8 , , , cord-302316-raf5rlkq 133 9 was be VBD cord-302316-raf5rlkq 133 10 detected detect VBN cord-302316-raf5rlkq 133 11 in in IN cord-302316-raf5rlkq 133 12 the the DT cord-302316-raf5rlkq 133 13 intestine intestine NN cord-302316-raf5rlkq 133 14 of of IN cord-302316-raf5rlkq 133 15 infected infected JJ cord-302316-raf5rlkq 133 16 cats cat NNS cord-302316-raf5rlkq 133 17 . . . cord-302316-raf5rlkq 134 1 Young young JJ cord-302316-raf5rlkq 134 2 cats cat NNS cord-302316-raf5rlkq 134 3 were be VBD cord-302316-raf5rlkq 134 4 found find VBN cord-302316-raf5rlkq 134 5 to to TO cord-302316-raf5rlkq 134 6 be be VB cord-302316-raf5rlkq 134 7 more more RBR cord-302316-raf5rlkq 134 8 susceptible susceptible JJ cord-302316-raf5rlkq 134 9 to to IN cord-302316-raf5rlkq 134 10 infection infection NN cord-302316-raf5rlkq 134 11 than than IN cord-302316-raf5rlkq 134 12 adult adult NN cord-302316-raf5rlkq 134 13 cats cat NNS cord-302316-raf5rlkq 134 14 . . . cord-302316-raf5rlkq 135 1 Dogs dog NNS cord-302316-raf5rlkq 135 2 that that WDT cord-302316-raf5rlkq 135 3 have have VBP cord-302316-raf5rlkq 135 4 been be VBN cord-302316-raf5rlkq 135 5 infected infect VBN cord-302316-raf5rlkq 135 6 showed show VBN cord-302316-raf5rlkq 135 7 viral viral JJ cord-302316-raf5rlkq 135 8 RNA RNA NNP cord-302316-raf5rlkq 135 9 in in IN cord-302316-raf5rlkq 135 10 the the DT cord-302316-raf5rlkq 135 11 intestine intestine NN cord-302316-raf5rlkq 135 12 , , , cord-302316-raf5rlkq 135 13 but but CC cord-302316-raf5rlkq 135 14 not not RB cord-302316-raf5rlkq 135 15 in in IN cord-302316-raf5rlkq 135 16 the the DT cord-302316-raf5rlkq 135 17 lung lung NN cord-302316-raf5rlkq 135 18 . . . cord-302316-raf5rlkq 136 1 No no DT cord-302316-raf5rlkq 136 2 infectious infectious JJ cord-302316-raf5rlkq 136 3 virus virus NN cord-302316-raf5rlkq 136 4 was be VBD cord-302316-raf5rlkq 136 5 found find VBN cord-302316-raf5rlkq 136 6 in in IN cord-302316-raf5rlkq 136 7 the the DT cord-302316-raf5rlkq 136 8 gut gut NN cord-302316-raf5rlkq 136 9 of of IN cord-302316-raf5rlkq 136 10 dogs dog NNS cord-302316-raf5rlkq 136 11 , , , cord-302316-raf5rlkq 136 12 indicating indicate VBG cord-302316-raf5rlkq 136 13 low low JJ cord-302316-raf5rlkq 136 14 susceptibility susceptibility NN cord-302316-raf5rlkq 136 15 of of IN cord-302316-raf5rlkq 136 16 dogs dog NNS cord-302316-raf5rlkq 136 17 for for IN cord-302316-raf5rlkq 136 18 this this DT cord-302316-raf5rlkq 136 19 virus virus NN cord-302316-raf5rlkq 136 20 . . . cord-302316-raf5rlkq 137 1 Pigs pig NNS cord-302316-raf5rlkq 137 2 , , , cord-302316-raf5rlkq 137 3 chickens chicken NNS cord-302316-raf5rlkq 137 4 and and CC cord-302316-raf5rlkq 137 5 ducks duck NNS cord-302316-raf5rlkq 137 6 could could MD cord-302316-raf5rlkq 137 7 not not RB cord-302316-raf5rlkq 137 8 be be VB cord-302316-raf5rlkq 137 9 infected infect VBN cord-302316-raf5rlkq 137 10 with with IN cord-302316-raf5rlkq 137 11 SARS SARS NNP cord-302316-raf5rlkq 137 12 - - HYPH cord-302316-raf5rlkq 137 13 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 137 14 . . . cord-302316-raf5rlkq 138 1 Animal animal NN cord-302316-raf5rlkq 138 2 models model NNS cord-302316-raf5rlkq 138 3 that that WDT cord-302316-raf5rlkq 138 4 reproduce reproduce VBP cord-302316-raf5rlkq 138 5 the the DT cord-302316-raf5rlkq 138 6 human human JJ cord-302316-raf5rlkq 138 7 infection infection NN cord-302316-raf5rlkq 138 8 are be VBP cord-302316-raf5rlkq 138 9 not not RB cord-302316-raf5rlkq 138 10 only only RB cord-302316-raf5rlkq 138 11 important important JJ cord-302316-raf5rlkq 138 12 for for IN cord-302316-raf5rlkq 138 13 the the DT cord-302316-raf5rlkq 138 14 understanding understanding NN cord-302316-raf5rlkq 138 15 of of IN cord-302316-raf5rlkq 138 16 the the DT cord-302316-raf5rlkq 138 17 pathology pathology NN cord-302316-raf5rlkq 138 18 of of IN cord-302316-raf5rlkq 138 19 COVID-19 covid-19 JJ cord-302316-raf5rlkq 138 20 infections infection NNS cord-302316-raf5rlkq 138 21 but but CC cord-302316-raf5rlkq 138 22 are be VBP cord-302316-raf5rlkq 138 23 also also RB cord-302316-raf5rlkq 138 24 crucial crucial JJ cord-302316-raf5rlkq 138 25 for for IN cord-302316-raf5rlkq 138 26 the the DT cord-302316-raf5rlkq 138 27 preclinical preclinical JJ cord-302316-raf5rlkq 138 28 testing testing NN cord-302316-raf5rlkq 138 29 of of IN cord-302316-raf5rlkq 138 30 antiviral antiviral JJ cord-302316-raf5rlkq 138 31 drugs drug NNS cord-302316-raf5rlkq 138 32 and and CC cord-302316-raf5rlkq 138 33 vaccine vaccine NN cord-302316-raf5rlkq 138 34 candidates candidate NNS cord-302316-raf5rlkq 138 35 . . . cord-302316-raf5rlkq 139 1 Ferrets ferret NNS cord-302316-raf5rlkq 139 2 , , , cord-302316-raf5rlkq 139 3 a a DT cord-302316-raf5rlkq 139 4 popular popular JJ cord-302316-raf5rlkq 139 5 model model NN cord-302316-raf5rlkq 139 6 for for IN cord-302316-raf5rlkq 139 7 respiratory respiratory JJ cord-302316-raf5rlkq 139 8 viral viral JJ cord-302316-raf5rlkq 139 9 infections infection NNS cord-302316-raf5rlkq 139 10 , , , cord-302316-raf5rlkq 139 11 developed develop VBN cord-302316-raf5rlkq 139 12 fever fever NN cord-302316-raf5rlkq 139 13 after after IN cord-302316-raf5rlkq 139 14 intranasal intranasal NN cord-302316-raf5rlkq 139 15 inoculation inoculation NN cord-302316-raf5rlkq 139 16 with with IN cord-302316-raf5rlkq 139 17 a a DT cord-302316-raf5rlkq 139 18 virus virus NN cord-302316-raf5rlkq 139 19 from from IN cord-302316-raf5rlkq 139 20 a a DT cord-302316-raf5rlkq 139 21 COVID-19 covid-19 JJ cord-302316-raf5rlkq 139 22 patient patient NN cord-302316-raf5rlkq 139 23 . . . cord-302316-raf5rlkq 140 1 Ferrets ferret NNS cord-302316-raf5rlkq 140 2 showed show VBD cord-302316-raf5rlkq 140 3 moderate moderate JJ cord-302316-raf5rlkq 140 4 titres titre NNS cord-302316-raf5rlkq 140 5 of of IN cord-302316-raf5rlkq 140 6 virus virus NN cord-302316-raf5rlkq 140 7 in in IN cord-302316-raf5rlkq 140 8 the the DT cord-302316-raf5rlkq 140 9 nose nose NN cord-302316-raf5rlkq 140 10 and and CC cord-302316-raf5rlkq 140 11 low low JJ cord-302316-raf5rlkq 140 12 viral viral JJ cord-302316-raf5rlkq 140 13 titres titre NNS cord-302316-raf5rlkq 140 14 in in IN cord-302316-raf5rlkq 140 15 the the DT cord-302316-raf5rlkq 140 16 lung lung NN cord-302316-raf5rlkq 140 17 and and CC cord-302316-raf5rlkq 140 18 intestine intestine NN cord-302316-raf5rlkq 140 19 and and CC cord-302316-raf5rlkq 140 20 displayed display VBD cord-302316-raf5rlkq 140 21 lung lung NN cord-302316-raf5rlkq 140 22 tissue tissue NN cord-302316-raf5rlkq 140 23 pathology pathology NN cord-302316-raf5rlkq 140 24 . . . cord-302316-raf5rlkq 141 1 Ferrets ferret NNS cord-302316-raf5rlkq 141 2 recovered recover VBD cord-302316-raf5rlkq 141 3 after after IN cord-302316-raf5rlkq 141 4 2 2 CD cord-302316-raf5rlkq 141 5 weeks week NNS cord-302316-raf5rlkq 141 6 and and CC cord-302316-raf5rlkq 141 7 seroconverted seroconverte VBD cord-302316-raf5rlkq 141 8 with with IN cord-302316-raf5rlkq 141 9 neutralizing neutralize VBG cord-302316-raf5rlkq 141 10 antibodies antibody NNS cord-302316-raf5rlkq 141 11 . . . cord-302316-raf5rlkq 142 1 Infected infected JJ cord-302316-raf5rlkq 142 2 ferrets ferret NNS cord-302316-raf5rlkq 142 3 transmitted transmit VBD cord-302316-raf5rlkq 142 4 the the DT cord-302316-raf5rlkq 142 5 infection infection NN cord-302316-raf5rlkq 142 6 efficiently efficiently RB cord-302316-raf5rlkq 142 7 in in IN cord-302316-raf5rlkq 142 8 the the DT cord-302316-raf5rlkq 142 9 presymptomatic presymptomatic JJ cord-302316-raf5rlkq 142 10 stage stage NN cord-302316-raf5rlkq 142 11 to to IN cord-302316-raf5rlkq 142 12 na€ na€ JJ cord-302316-raf5rlkq 142 13 ıve ıve JJ cord-302316-raf5rlkq 142 14 ferrets ferret NNS cord-302316-raf5rlkq 142 15 not not RB cord-302316-raf5rlkq 142 16 only only RB cord-302316-raf5rlkq 142 17 via via IN cord-302316-raf5rlkq 142 18 close close JJ cord-302316-raf5rlkq 142 19 contact contact NN cord-302316-raf5rlkq 142 20 , , , cord-302316-raf5rlkq 142 21 but but CC cord-302316-raf5rlkq 142 22 also also RB cord-302316-raf5rlkq 142 23 , , , cord-302316-raf5rlkq 142 24 albeit albeit IN cord-302316-raf5rlkq 142 25 less less RBR cord-302316-raf5rlkq 142 26 efficiently efficiently RB cord-302316-raf5rlkq 142 27 , , , cord-302316-raf5rlkq 142 28 to to IN cord-302316-raf5rlkq 142 29 ferrets ferret NNS cord-302316-raf5rlkq 142 30 in in IN cord-302316-raf5rlkq 142 31 separate separate JJ cord-302316-raf5rlkq 142 32 cages cage NNS cord-302316-raf5rlkq 143 1 ( ( -LRB- cord-302316-raf5rlkq 143 2 Kim Kim NNP cord-302316-raf5rlkq 143 3 et et NNP cord-302316-raf5rlkq 143 4 al al NNP cord-302316-raf5rlkq 143 5 . . NNP cord-302316-raf5rlkq 143 6 , , , cord-302316-raf5rlkq 143 7 2020 2020 CD cord-302316-raf5rlkq 143 8 ) ) -RRB- cord-302316-raf5rlkq 143 9 . . . cord-302316-raf5rlkq 144 1 Hamsters hamster NNS cord-302316-raf5rlkq 144 2 , , , cord-302316-raf5rlkq 144 3 infected infect VBN cord-302316-raf5rlkq 144 4 with with IN cord-302316-raf5rlkq 144 5 a a DT cord-302316-raf5rlkq 144 6 virus virus NN cord-302316-raf5rlkq 144 7 from from IN cord-302316-raf5rlkq 144 8 a a DT cord-302316-raf5rlkq 144 9 Hong Hong NNP cord-302316-raf5rlkq 144 10 Kong Kong NNP cord-302316-raf5rlkq 144 11 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 144 12 patient patient NN cord-302316-raf5rlkq 144 13 , , , cord-302316-raf5rlkq 144 14 showed show VBD cord-302316-raf5rlkq 144 15 weight weight NN cord-302316-raf5rlkq 144 16 loss loss NN cord-302316-raf5rlkq 144 17 , , , cord-302316-raf5rlkq 144 18 lethargy lethargy NN cord-302316-raf5rlkq 144 19 and and CC cord-302316-raf5rlkq 144 20 rapid rapid JJ cord-302316-raf5rlkq 144 21 breathing breathing NN cord-302316-raf5rlkq 144 22 . . . cord-302316-raf5rlkq 145 1 High high JJ cord-302316-raf5rlkq 145 2 virus virus NN cord-302316-raf5rlkq 145 3 titres titre NNS cord-302316-raf5rlkq 145 4 were be VBD cord-302316-raf5rlkq 145 5 found find VBN cord-302316-raf5rlkq 145 6 in in IN cord-302316-raf5rlkq 145 7 the the DT cord-302316-raf5rlkq 145 8 nose nose NN cord-302316-raf5rlkq 145 9 , , , cord-302316-raf5rlkq 145 10 the the DT cord-302316-raf5rlkq 145 11 lung lung NN cord-302316-raf5rlkq 145 12 and and CC cord-302316-raf5rlkq 145 13 in in IN cord-302316-raf5rlkq 145 14 the the DT cord-302316-raf5rlkq 145 15 intestine intestine NN cord-302316-raf5rlkq 145 16 . . . cord-302316-raf5rlkq 146 1 Histopathological Histopathological NNP cord-302316-raf5rlkq 146 2 changes change NNS cord-302316-raf5rlkq 146 3 were be VBD cord-302316-raf5rlkq 146 4 seen see VBN cord-302316-raf5rlkq 146 5 in in IN cord-302316-raf5rlkq 146 6 the the DT cord-302316-raf5rlkq 146 7 nose nose NN cord-302316-raf5rlkq 146 8 , , , cord-302316-raf5rlkq 146 9 the the DT cord-302316-raf5rlkq 146 10 trachea trachea NN cord-302316-raf5rlkq 146 11 and and CC cord-302316-raf5rlkq 146 12 the the DT cord-302316-raf5rlkq 146 13 lung lung NN cord-302316-raf5rlkq 146 14 displaying display VBG cord-302316-raf5rlkq 146 15 alveolar alveolar JJ cord-302316-raf5rlkq 146 16 destruction destruction NN cord-302316-raf5rlkq 146 17 , , , cord-302316-raf5rlkq 146 18 but but CC cord-302316-raf5rlkq 146 19 also also RB cord-302316-raf5rlkq 146 20 in in IN cord-302316-raf5rlkq 146 21 the the DT cord-302316-raf5rlkq 146 22 gut gut NN cord-302316-raf5rlkq 146 23 demonstrating demonstrate VBG cord-302316-raf5rlkq 146 24 epithelial epithelial JJ cord-302316-raf5rlkq 146 25 necrosis necrosis NN cord-302316-raf5rlkq 146 26 . . . cord-302316-raf5rlkq 147 1 Interferon interferon NN cord-302316-raf5rlkq 147 2 and and CC cord-302316-raf5rlkq 147 3 pro pro JJ cord-302316-raf5rlkq 147 4 - - JJ cord-302316-raf5rlkq 147 5 inflammatory inflammatory JJ cord-302316-raf5rlkq 147 6 cytokines cytokine NNS cord-302316-raf5rlkq 147 7 were be VBD cord-302316-raf5rlkq 147 8 rapidly rapidly RB cord-302316-raf5rlkq 147 9 induced induce VBN cord-302316-raf5rlkq 147 10 , , , cord-302316-raf5rlkq 147 11 reached reach VBN cord-302316-raf5rlkq 147 12 peak peak NN cord-302316-raf5rlkq 147 13 titres titre NNS cord-302316-raf5rlkq 147 14 and and CC cord-302316-raf5rlkq 147 15 dropped drop VBD cord-302316-raf5rlkq 147 16 after after IN cord-302316-raf5rlkq 147 17 a a DT cord-302316-raf5rlkq 147 18 week week NN cord-302316-raf5rlkq 147 19 with with IN cord-302316-raf5rlkq 147 20 the the DT cord-302316-raf5rlkq 147 21 development development NN cord-302316-raf5rlkq 147 22 of of IN cord-302316-raf5rlkq 147 23 neutralizing neutralize VBG cord-302316-raf5rlkq 147 24 antibodies antibody NNS cord-302316-raf5rlkq 147 25 and and CC cord-302316-raf5rlkq 147 26 recovery recovery NN cord-302316-raf5rlkq 147 27 from from IN cord-302316-raf5rlkq 147 28 disease disease NN cord-302316-raf5rlkq 147 29 . . . cord-302316-raf5rlkq 148 1 Na€ Na€ NNP cord-302316-raf5rlkq 148 2 ıve ıve JJ cord-302316-raf5rlkq 148 3 contact contact NN cord-302316-raf5rlkq 148 4 hamster hamster NN cord-302316-raf5rlkq 148 5 were be VBD cord-302316-raf5rlkq 148 6 efficiently efficiently RB cord-302316-raf5rlkq 148 7 infected infect VBN cord-302316-raf5rlkq 148 8 , , , cord-302316-raf5rlkq 148 9 but but CC cord-302316-raf5rlkq 148 10 showed show VBD cord-302316-raf5rlkq 148 11 less less JJR cord-302316-raf5rlkq 148 12 weight weight NN cord-302316-raf5rlkq 148 13 loss loss NN cord-302316-raf5rlkq 148 14 . . . cord-302316-raf5rlkq 149 1 Macaques macaque NNS cord-302316-raf5rlkq 149 2 have have VBP cord-302316-raf5rlkq 149 3 been be VBN cord-302316-raf5rlkq 149 4 infected infect VBN cord-302316-raf5rlkq 149 5 with with IN cord-302316-raf5rlkq 149 6 SARS SARS NNP cord-302316-raf5rlkq 149 7 - - HYPH cord-302316-raf5rlkq 149 8 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 149 9 but but CC cord-302316-raf5rlkq 149 10 showed show VBD cord-302316-raf5rlkq 149 11 no no DT cord-302316-raf5rlkq 149 12 clinical clinical JJ cord-302316-raf5rlkq 149 13 symptoms symptom NNS cord-302316-raf5rlkq 149 14 , , , cord-302316-raf5rlkq 149 15 except except IN cord-302316-raf5rlkq 149 16 for for IN cord-302316-raf5rlkq 149 17 moderate moderate JJ cord-302316-raf5rlkq 149 18 titres titre NNS cord-302316-raf5rlkq 149 19 of of IN cord-302316-raf5rlkq 149 20 virus virus NN cord-302316-raf5rlkq 149 21 excreted excrete VBN cord-302316-raf5rlkq 149 22 from from IN cord-302316-raf5rlkq 149 23 the the DT cord-302316-raf5rlkq 149 24 nose nose NN cord-302316-raf5rlkq 149 25 and and CC cord-302316-raf5rlkq 149 26 throat throat NN cord-302316-raf5rlkq 149 27 . . . cord-302316-raf5rlkq 150 1 Maximal maximal JJ cord-302316-raf5rlkq 150 2 viral viral JJ cord-302316-raf5rlkq 150 3 titres titre NNS cord-302316-raf5rlkq 150 4 were be VBD cord-302316-raf5rlkq 150 5 seen see VBN cord-302316-raf5rlkq 150 6 early early RB cord-302316-raf5rlkq 150 7 after after IN cord-302316-raf5rlkq 150 8 infection infection NN cord-302316-raf5rlkq 150 9 , , , cord-302316-raf5rlkq 150 10 and and CC cord-302316-raf5rlkq 150 11 titres titre NNS cord-302316-raf5rlkq 150 12 were be VBD cord-302316-raf5rlkq 150 13 higher high JJR cord-302316-raf5rlkq 150 14 in in IN cord-302316-raf5rlkq 150 15 older old JJR cord-302316-raf5rlkq 150 16 animals animal NNS cord-302316-raf5rlkq 150 17 . . . cord-302316-raf5rlkq 151 1 Upon upon IN cord-302316-raf5rlkq 151 2 autopsy autopsy JJ cord-302316-raf5rlkq 151 3 , , , cord-302316-raf5rlkq 151 4 pulmonary pulmonary JJ cord-302316-raf5rlkq 151 5 damage damage NN cord-302316-raf5rlkq 151 6 presented present VBN cord-302316-raf5rlkq 151 7 as as IN cord-302316-raf5rlkq 151 8 the the DT cord-302316-raf5rlkq 151 9 diffuse diffuse JJ cord-302316-raf5rlkq 151 10 alveolar alveolar NN cord-302316-raf5rlkq 151 11 damage damage NN cord-302316-raf5rlkq 151 12 that that WDT cord-302316-raf5rlkq 151 13 is be VBZ cord-302316-raf5rlkq 151 14 associated associate VBN cord-302316-raf5rlkq 151 15 with with IN cord-302316-raf5rlkq 151 16 replicating replicate VBG cord-302316-raf5rlkq 151 17 virus virus NN cord-302316-raf5rlkq 151 18 . . . cord-302316-raf5rlkq 152 1 The the DT cord-302316-raf5rlkq 152 2 animals animal NNS cord-302316-raf5rlkq 152 3 seroconverted seroconverte VBD cord-302316-raf5rlkq 152 4 ( ( -LRB- cord-302316-raf5rlkq 152 5 Rockx Rockx NNP cord-302316-raf5rlkq 152 6 et et NNP cord-302316-raf5rlkq 152 7 al al NNP cord-302316-raf5rlkq 152 8 . . NNP cord-302316-raf5rlkq 152 9 , , , cord-302316-raf5rlkq 152 10 2020 2020 CD cord-302316-raf5rlkq 152 11 ) ) -RRB- cord-302316-raf5rlkq 152 12 . . . cord-302316-raf5rlkq 153 1 Also also RB cord-302316-raf5rlkq 153 2 , , , cord-302316-raf5rlkq 153 3 rhesus rhesu NNS cord-302316-raf5rlkq 153 4 monkeys monkey NNS cord-302316-raf5rlkq 153 5 showed show VBD cord-302316-raf5rlkq 153 6 viral viral JJ cord-302316-raf5rlkq 153 7 replication replication NN cord-302316-raf5rlkq 153 8 in in IN cord-302316-raf5rlkq 153 9 the the DT cord-302316-raf5rlkq 153 10 pharynx pharynx NN cord-302316-raf5rlkq 153 11 and and CC cord-302316-raf5rlkq 153 12 severe severe JJ cord-302316-raf5rlkq 153 13 interstitial interstitial JJ cord-302316-raf5rlkq 153 14 pneumonia pneumonia NN cord-302316-raf5rlkq 153 15 . . . cord-302316-raf5rlkq 154 1 Lung lung NN cord-302316-raf5rlkq 154 2 tissue tissue NN cord-302316-raf5rlkq 154 3 from from IN cord-302316-raf5rlkq 154 4 17 17 CD cord-302316-raf5rlkq 154 5 of of IN cord-302316-raf5rlkq 154 6 25 25 CD cord-302316-raf5rlkq 154 7 Malayan malayan JJ cord-302316-raf5rlkq 154 8 pangolins pangolin NNS cord-302316-raf5rlkq 154 9 from from IN cord-302316-raf5rlkq 154 10 a a DT cord-302316-raf5rlkq 154 11 wildlife wildlife NN cord-302316-raf5rlkq 154 12 rescue rescue NN cord-302316-raf5rlkq 154 13 centre centre NN cord-302316-raf5rlkq 154 14 in in IN cord-302316-raf5rlkq 154 15 China China NNP cord-302316-raf5rlkq 154 16 yielded yield VBD cord-302316-raf5rlkq 154 17 a a DT cord-302316-raf5rlkq 154 18 positive positive JJ cord-302316-raf5rlkq 154 19 result result NN cord-302316-raf5rlkq 154 20 for for IN cord-302316-raf5rlkq 154 21 SARS SARS NNP cord-302316-raf5rlkq 154 22 - - HYPH cord-302316-raf5rlkq 154 23 CoV-2-related cov-2-relate VBN cord-302316-raf5rlkq 154 24 sequences sequence NNS cord-302316-raf5rlkq 154 25 . . . cord-302316-raf5rlkq 155 1 Pangolins pangolin NNS cord-302316-raf5rlkq 155 2 are be VBP cord-302316-raf5rlkq 155 3 suspected suspect VBN cord-302316-raf5rlkq 155 4 to to TO cord-302316-raf5rlkq 155 5 have have VB cord-302316-raf5rlkq 155 6 been be VBN cord-302316-raf5rlkq 155 7 intermediate intermediate JJ cord-302316-raf5rlkq 155 8 hosts host NNS cord-302316-raf5rlkq 155 9 at at IN cord-302316-raf5rlkq 155 10 the the DT cord-302316-raf5rlkq 155 11 wet wet JJ cord-302316-raf5rlkq 155 12 food food NN cord-302316-raf5rlkq 155 13 market market NN cord-302316-raf5rlkq 155 14 from from IN cord-302316-raf5rlkq 155 15 Wuhan Wuhan NNP cord-302316-raf5rlkq 155 16 , , , cord-302316-raf5rlkq 155 17 where where WRB cord-302316-raf5rlkq 155 18 the the DT cord-302316-raf5rlkq 155 19 epidemic epidemic NN cord-302316-raf5rlkq 155 20 started start VBD cord-302316-raf5rlkq 155 21 . . . cord-302316-raf5rlkq 156 1 Fourteen fourteen CD cord-302316-raf5rlkq 156 2 of of IN cord-302316-raf5rlkq 156 3 the the DT cord-302316-raf5rlkq 156 4 pangolins pangolin NNS cord-302316-raf5rlkq 156 5 died die VBD cord-302316-raf5rlkq 156 6 , , , cord-302316-raf5rlkq 156 7 showing show VBG cord-302316-raf5rlkq 156 8 lung lung NN cord-302316-raf5rlkq 156 9 consolidation consolidation NN cord-302316-raf5rlkq 156 10 and and CC cord-302316-raf5rlkq 156 11 diffuse diffuse VB cord-302316-raf5rlkq 156 12 alveolar alveolar NN cord-302316-raf5rlkq 156 13 damage damage NN cord-302316-raf5rlkq 156 14 similar similar JJ cord-302316-raf5rlkq 156 15 to to IN cord-302316-raf5rlkq 156 16 human human JJ cord-302316-raf5rlkq 156 17 COVID-19 covid-19 JJ cord-302316-raf5rlkq 156 18 victims victim NNS cord-302316-raf5rlkq 156 19 . . . cord-302316-raf5rlkq 157 1 A a DT cord-302316-raf5rlkq 157 2 complete complete JJ cord-302316-raf5rlkq 157 3 coronavirus coronavirus NN cord-302316-raf5rlkq 157 4 genome genome NN cord-302316-raf5rlkq 157 5 has have VBZ cord-302316-raf5rlkq 157 6 been be VBN cord-302316-raf5rlkq 157 7 constructed construct VBN cord-302316-raf5rlkq 157 8 from from IN cord-302316-raf5rlkq 157 9 RNA RNA NNP cord-302316-raf5rlkq 157 10 sequencing sequencing NN cord-302316-raf5rlkq 157 11 of of IN cord-302316-raf5rlkq 157 12 the the DT cord-302316-raf5rlkq 157 13 lung lung NN cord-302316-raf5rlkq 157 14 tissues tissue NNS cord-302316-raf5rlkq 157 15 obtained obtain VBN cord-302316-raf5rlkq 157 16 from from IN cord-302316-raf5rlkq 157 17 trafficked traffic VBN cord-302316-raf5rlkq 157 18 Malayan Malayan NNP cord-302316-raf5rlkq 157 19 , , , cord-302316-raf5rlkq 157 20 but but CC cord-302316-raf5rlkq 157 21 not not RB cord-302316-raf5rlkq 157 22 Chinese chinese JJ cord-302316-raf5rlkq 157 23 , , , cord-302316-raf5rlkq 157 24 pangolins pangolin NNS cord-302316-raf5rlkq 157 25 which which WDT cord-302316-raf5rlkq 157 26 represent represent VBP cord-302316-raf5rlkq 157 27 two two CD cord-302316-raf5rlkq 157 28 distinct distinct JJ cord-302316-raf5rlkq 157 29 species specie NNS cord-302316-raf5rlkq 157 30 . . . cord-302316-raf5rlkq 158 1 The the DT cord-302316-raf5rlkq 158 2 Malayan malayan JJ cord-302316-raf5rlkq 158 3 pangolin pangolin NN cord-302316-raf5rlkq 158 4 coronavirus coronavirus NN cord-302316-raf5rlkq 158 5 is be VBZ cord-302316-raf5rlkq 158 6 not not RB cord-302316-raf5rlkq 158 7 a a DT cord-302316-raf5rlkq 158 8 direct direct JJ cord-302316-raf5rlkq 158 9 precursor precursor NN cord-302316-raf5rlkq 158 10 to to IN cord-302316-raf5rlkq 158 11 SARS SARS NNP cord-302316-raf5rlkq 158 12 - - HYPH cord-302316-raf5rlkq 158 13 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 158 14 , , , cord-302316-raf5rlkq 158 15 because because IN cord-302316-raf5rlkq 158 16 its -PRON- PRP$ cord-302316-raf5rlkq 158 17 genome genome NN cord-302316-raf5rlkq 158 18 differs differ VBZ cord-302316-raf5rlkq 158 19 too too RB cord-302316-raf5rlkq 158 20 much much RB cord-302316-raf5rlkq 158 21 from from IN cord-302316-raf5rlkq 158 22 the the DT cord-302316-raf5rlkq 158 23 human human JJ cord-302316-raf5rlkq 158 24 isolates isolate NNS cord-302316-raf5rlkq 158 25 , , , cord-302316-raf5rlkq 158 26 but but CC cord-302316-raf5rlkq 158 27 may may MD cord-302316-raf5rlkq 158 28 have have VB cord-302316-raf5rlkq 158 29 contributed contribute VBN cord-302316-raf5rlkq 158 30 the the DT cord-302316-raf5rlkq 158 31 receptor receptor NN cord-302316-raf5rlkq 158 32 binding bind VBG cord-302316-raf5rlkq 158 33 domain domain NN cord-302316-raf5rlkq 158 34 of of IN cord-302316-raf5rlkq 158 35 the the DT cord-302316-raf5rlkq 158 36 spike spike NN cord-302316-raf5rlkq 158 37 protein protein NN cord-302316-raf5rlkq 158 38 gene gene NN cord-302316-raf5rlkq 158 39 by by IN cord-302316-raf5rlkq 158 40 genetic genetic JJ cord-302316-raf5rlkq 158 41 recombination recombination NN cord-302316-raf5rlkq 158 42 with with IN cord-302316-raf5rlkq 158 43 a a DT cord-302316-raf5rlkq 158 44 bat bat NN cord-302316-raf5rlkq 158 45 coronavirus coronavirus NN cord-302316-raf5rlkq 158 46 . . . cord-302316-raf5rlkq 159 1 Pangolins pangolin NNS cord-302316-raf5rlkq 159 2 and and CC cord-302316-raf5rlkq 159 3 bats bat NNS cord-302316-raf5rlkq 159 4 are be VBP cord-302316-raf5rlkq 159 5 both both DT cord-302316-raf5rlkq 159 6 nocturnal nocturnal JJ cord-302316-raf5rlkq 159 7 animals animal NNS cord-302316-raf5rlkq 159 8 that that WDT cord-302316-raf5rlkq 159 9 both both DT cord-302316-raf5rlkq 159 10 eat eat VBP cord-302316-raf5rlkq 159 11 insects insect NNS cord-302316-raf5rlkq 159 12 and and CC cord-302316-raf5rlkq 159 13 share share VB cord-302316-raf5rlkq 159 14 overlapping overlap VBG cord-302316-raf5rlkq 159 15 ecological ecological JJ cord-302316-raf5rlkq 159 16 niches niche NNS cord-302316-raf5rlkq 159 17 , , , cord-302316-raf5rlkq 159 18 rendering render VBG cord-302316-raf5rlkq 159 19 contact contact NN cord-302316-raf5rlkq 159 20 likely likely JJ cord-302316-raf5rlkq 160 1 ( ( -LRB- cord-302316-raf5rlkq 160 2 Xiao Xiao NNP cord-302316-raf5rlkq 160 3 et et NNP cord-302316-raf5rlkq 160 4 al al NNP cord-302316-raf5rlkq 160 5 . . NNP cord-302316-raf5rlkq 160 6 , , , cord-302316-raf5rlkq 160 7 2020 2020 CD cord-302316-raf5rlkq 160 8 ) ) -RRB- cord-302316-raf5rlkq 160 9 . . . cord-302316-raf5rlkq 161 1 To to TO cord-302316-raf5rlkq 161 2 fulfil fulfil VB cord-302316-raf5rlkq 161 3 Koch Koch NNP cord-302316-raf5rlkq 161 4 's 's POS cord-302316-raf5rlkq 161 5 postulates postulate NNS cord-302316-raf5rlkq 161 6 , , , cord-302316-raf5rlkq 161 7 transgenic transgenic JJ cord-302316-raf5rlkq 161 8 mice mouse NNS cord-302316-raf5rlkq 161 9 expressing express VBG cord-302316-raf5rlkq 161 10 the the DT cord-302316-raf5rlkq 161 11 human human NN cord-302316-raf5rlkq 161 12 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 161 13 were be VBD cord-302316-raf5rlkq 161 14 infected infect VBN cord-302316-raf5rlkq 161 15 with with IN cord-302316-raf5rlkq 161 16 a a DT cord-302316-raf5rlkq 161 17 SARS SARS NNP cord-302316-raf5rlkq 161 18 - - HYPH cord-302316-raf5rlkq 161 19 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 161 20 isolate isolate VBP cord-302316-raf5rlkq 161 21 from from IN cord-302316-raf5rlkq 161 22 a a DT cord-302316-raf5rlkq 161 23 Chinese chinese JJ cord-302316-raf5rlkq 161 24 patient patient NN cord-302316-raf5rlkq 161 25 . . . cord-302316-raf5rlkq 162 1 Transgenic transgenic JJ cord-302316-raf5rlkq 162 2 mice mouse NNS cord-302316-raf5rlkq 162 3 , , , cord-302316-raf5rlkq 162 4 but but CC cord-302316-raf5rlkq 162 5 not not RB cord-302316-raf5rlkq 162 6 wild wild JJ cord-302316-raf5rlkq 162 7 - - HYPH cord-302316-raf5rlkq 162 8 type type NN cord-302316-raf5rlkq 162 9 mice mice NN cord-302316-raf5rlkq 162 10 ( ( -LRB- cord-302316-raf5rlkq 162 11 which which WDT cord-302316-raf5rlkq 162 12 lack lack VBP cord-302316-raf5rlkq 162 13 the the DT cord-302316-raf5rlkq 162 14 viral viral JJ cord-302316-raf5rlkq 162 15 cell cell NN cord-302316-raf5rlkq 162 16 receptor receptor NN cord-302316-raf5rlkq 162 17 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 162 18 ) ) -RRB- cord-302316-raf5rlkq 162 19 , , , cord-302316-raf5rlkq 162 20 showed show VBD cord-302316-raf5rlkq 162 21 symptoms symptom NNS cord-302316-raf5rlkq 162 22 of of IN cord-302316-raf5rlkq 162 23 disease disease NN cord-302316-raf5rlkq 162 24 ( ( -LRB- cord-302316-raf5rlkq 162 25 interstitial interstitial JJ cord-302316-raf5rlkq 162 26 pneumonia pneumonia NN cord-302316-raf5rlkq 162 27 ) ) -RRB- cord-302316-raf5rlkq 162 28 thatpartiallyreproduced thatpartiallyreproduce VBD cord-302316-raf5rlkq 162 29 the the DT cord-302316-raf5rlkq 162 30 disease disease NN cord-302316-raf5rlkq 162 31 in in IN cord-302316-raf5rlkq 162 32 humans human NNS cord-302316-raf5rlkq 162 33 . . . cord-302316-raf5rlkq 163 1 The the DT cord-302316-raf5rlkq 163 2 virus virus NN cord-302316-raf5rlkq 163 3 replicated replicate VBD cord-302316-raf5rlkq 163 4 in in IN cord-302316-raf5rlkq 163 5 the the DT cord-302316-raf5rlkq 163 6 organ organ NN cord-302316-raf5rlkq 163 7 where where WRB cord-302316-raf5rlkq 163 8 the the DT cord-302316-raf5rlkq 163 9 pathology pathology NN cord-302316-raf5rlkq 163 10 was be VBD cord-302316-raf5rlkq 163 11 observed observe VBN cord-302316-raf5rlkq 163 12 , , , cord-302316-raf5rlkq 163 13 and and CC cord-302316-raf5rlkq 163 14 -finally -finally RB cord-302316-raf5rlkq 163 15 the the DT cord-302316-raf5rlkq 163 16 virus virus NN cord-302316-raf5rlkq 163 17 could could MD cord-302316-raf5rlkq 163 18 be be VB cord-302316-raf5rlkq 163 19 re re VBN cord-302316-raf5rlkq 163 20 - - VBN cord-302316-raf5rlkq 163 21 isolated isolate VBN cord-302316-raf5rlkq 163 22 from from IN cord-302316-raf5rlkq 163 23 this this DT cord-302316-raf5rlkq 163 24 organ organ NN cord-302316-raf5rlkq 163 25 . . . cord-302316-raf5rlkq 164 1 One one CD cord-302316-raf5rlkq 164 2 overt overt JJ cord-302316-raf5rlkq 164 3 clinical clinical JJ cord-302316-raf5rlkq 164 4 sign sign NN cord-302316-raf5rlkq 164 5 was be VBD cord-302316-raf5rlkq 164 6 weight weight NN cord-302316-raf5rlkq 164 7 loss loss NN cord-302316-raf5rlkq 164 8 in in IN cord-302316-raf5rlkq 164 9 mice mouse NNS cord-302316-raf5rlkq 164 10 . . . cord-302316-raf5rlkq 165 1 Also also RB cord-302316-raf5rlkq 165 2 , , , cord-302316-raf5rlkq 165 3 viral viral JJ cord-302316-raf5rlkq 165 4 replication replication NN cord-302316-raf5rlkq 165 5 produced produce VBD cord-302316-raf5rlkq 165 6 moderate moderate JJ cord-302316-raf5rlkq 165 7 peak peak NN cord-302316-raf5rlkq 165 8 titres titre NNS cord-302316-raf5rlkq 165 9 and and CC cord-302316-raf5rlkq 165 10 was be VBD cord-302316-raf5rlkq 165 11 limited limit VBN cord-302316-raf5rlkq 165 12 to to IN cord-302316-raf5rlkq 165 13 the the DT cord-302316-raf5rlkq 165 14 lung lung NN cord-302316-raf5rlkq 165 15 and and CC cord-302316-raf5rlkq 165 16 bronchi bronchi NN cord-302316-raf5rlkq 165 17 . . . cord-302316-raf5rlkq 166 1 After after IN cord-302316-raf5rlkq 166 2 much much JJ cord-302316-raf5rlkq 166 3 media medium NNS cord-302316-raf5rlkq 166 4 hype hype NN cord-302316-raf5rlkq 166 5 , , , cord-302316-raf5rlkq 166 6 political political JJ cord-302316-raf5rlkq 166 7 support support NN cord-302316-raf5rlkq 166 8 and and CC cord-302316-raf5rlkq 166 9 Emergency Emergency NNP cord-302316-raf5rlkq 166 10 Use Use NNP cord-302316-raf5rlkq 166 11 Authorization Authorization NNP cord-302316-raf5rlkq 166 12 by by IN cord-302316-raf5rlkq 166 13 the the DT cord-302316-raf5rlkq 166 14 FDA FDA NNP cord-302316-raf5rlkq 166 15 , , , cord-302316-raf5rlkq 166 16 the the DT cord-302316-raf5rlkq 166 17 initial initial JJ cord-302316-raf5rlkq 166 18 high high JJ cord-302316-raf5rlkq 166 19 hopes hope NNS cord-302316-raf5rlkq 166 20 placed place VBN cord-302316-raf5rlkq 166 21 in in IN cord-302316-raf5rlkq 166 22 the the DT cord-302316-raf5rlkq 166 23 repurposed repurpose VBN cord-302316-raf5rlkq 166 24 malaria malaria NNP cord-302316-raf5rlkq 166 25 drug drug NN cord-302316-raf5rlkq 166 26 hydroxychloroquine hydroxychloroquine NNP cord-302316-raf5rlkq 166 27 administered administer VBN cord-302316-raf5rlkq 166 28 to to IN cord-302316-raf5rlkq 166 29 hospitalized hospitalize VBN cord-302316-raf5rlkq 166 30 COVID-19 COVID-19 , cord-302316-raf5rlkq 166 31 patients patient NNS cord-302316-raf5rlkq 166 32 were be VBD cord-302316-raf5rlkq 166 33 not not RB cord-302316-raf5rlkq 166 34 validated validate VBN cord-302316-raf5rlkq 166 35 by by IN cord-302316-raf5rlkq 166 36 clinical clinical JJ cord-302316-raf5rlkq 166 37 data datum NNS cord-302316-raf5rlkq 166 38 , , , cord-302316-raf5rlkq 166 39 which which WDT cord-302316-raf5rlkq 166 40 had have VBD cord-302316-raf5rlkq 166 41 shown show VBN cord-302316-raf5rlkq 166 42 only only RB cord-302316-raf5rlkq 166 43 mixed mixed JJ cord-302316-raf5rlkq 166 44 results result NNS cord-302316-raf5rlkq 166 45 . . . cord-302316-raf5rlkq 167 1 Chloroquine chloroquine NN cord-302316-raf5rlkq 167 2 increases increase VBZ cord-302316-raf5rlkq 167 3 endosomal endosomal NNP cord-302316-raf5rlkq 167 4 and and CC cord-302316-raf5rlkq 167 5 lysosomal lysosomal JJ cord-302316-raf5rlkq 167 6 pH ph NN cord-302316-raf5rlkq 167 7 and and CC cord-302316-raf5rlkq 167 8 interferes interfere VBZ cord-302316-raf5rlkq 167 9 with with IN cord-302316-raf5rlkq 167 10 some some DT cord-302316-raf5rlkq 167 11 viral viral JJ cord-302316-raf5rlkq 167 12 infections infection NNS cord-302316-raf5rlkq 167 13 in in IN cord-302316-raf5rlkq 167 14 cell cell NN cord-302316-raf5rlkq 167 15 culture culture NN cord-302316-raf5rlkq 167 16 . . . cord-302316-raf5rlkq 168 1 A a DT cord-302316-raf5rlkq 168 2 small small JJ cord-302316-raf5rlkq 168 3 Chinese chinese JJ cord-302316-raf5rlkq 168 4 trial trial NN cord-302316-raf5rlkq 168 5 enrolling enrol VBG cord-302316-raf5rlkq 168 6 62 62 CD cord-302316-raf5rlkq 168 7 COVID-19 covid-19 CD cord-302316-raf5rlkq 168 8 patients patient NNS cord-302316-raf5rlkq 168 9 on on IN cord-302316-raf5rlkq 168 10 hydroxychloroquine hydroxychloroquine NN cord-302316-raf5rlkq 168 11 , , , cord-302316-raf5rlkq 168 12 or or CC cord-302316-raf5rlkq 168 13 placebo placebo NN cord-302316-raf5rlkq 168 14 , , , cord-302316-raf5rlkq 168 15 showed show VBD cord-302316-raf5rlkq 168 16 , , , cord-302316-raf5rlkq 168 17 in in IN cord-302316-raf5rlkq 168 18 fact fact NN cord-302316-raf5rlkq 168 19 , , , cord-302316-raf5rlkq 168 20 a a DT cord-302316-raf5rlkq 168 21 shortened shorten VBN cord-302316-raf5rlkq 168 22 period period NN cord-302316-raf5rlkq 168 23 of of IN cord-302316-raf5rlkq 168 24 recovery recovery NN cord-302316-raf5rlkq 168 25 from from IN cord-302316-raf5rlkq 168 26 fever fever NN cord-302316-raf5rlkq 168 27 and and CC cord-302316-raf5rlkq 168 28 cough cough NN cord-302316-raf5rlkq 168 29 in in IN cord-302316-raf5rlkq 168 30 the the DT cord-302316-raf5rlkq 168 31 treatment treatment NN cord-302316-raf5rlkq 168 32 group group NN cord-302316-raf5rlkq 168 33 . . . cord-302316-raf5rlkq 169 1 A a DT cord-302316-raf5rlkq 169 2 French french JJ cord-302316-raf5rlkq 169 3 study study NN cord-302316-raf5rlkq 169 4 randomizing randomize VBG cord-302316-raf5rlkq 169 5 181 181 CD cord-302316-raf5rlkq 169 6 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 169 7 patients patient NNS cord-302316-raf5rlkq 169 8 with with IN cord-302316-raf5rlkq 169 9 pneumonia pneumonia NN cord-302316-raf5rlkq 169 10 on on IN cord-302316-raf5rlkq 169 11 hydroxychloroquine hydroxychloroquine NN cord-302316-raf5rlkq 169 12 or or CC cord-302316-raf5rlkq 169 13 placebo placebo NN cord-302316-raf5rlkq 169 14 , , , cord-302316-raf5rlkq 169 15 observed observe VBD cord-302316-raf5rlkq 169 16 , , , cord-302316-raf5rlkq 169 17 however however RB cord-302316-raf5rlkq 169 18 , , , cord-302316-raf5rlkq 169 19 no no DT cord-302316-raf5rlkq 169 20 significant significant JJ cord-302316-raf5rlkq 169 21 effect effect NN cord-302316-raf5rlkq 169 22 of of IN cord-302316-raf5rlkq 169 23 treatment treatment NN cord-302316-raf5rlkq 169 24 on on IN cord-302316-raf5rlkq 169 25 transfer transfer NN cord-302316-raf5rlkq 169 26 to to IN cord-302316-raf5rlkq 169 27 ICU ICU NNP cord-302316-raf5rlkq 169 28 , , , cord-302316-raf5rlkq 169 29 mortality mortality NN cord-302316-raf5rlkq 169 30 , , , cord-302316-raf5rlkq 169 31 or or CC cord-302316-raf5rlkq 169 32 in in IN cord-302316-raf5rlkq 169 33 the the DT cord-302316-raf5rlkq 169 34 prevention prevention NN cord-302316-raf5rlkq 169 35 of of IN cord-302316-raf5rlkq 169 36 development development NN cord-302316-raf5rlkq 169 37 of of IN cord-302316-raf5rlkq 169 38 acute acute JJ cord-302316-raf5rlkq 169 39 respiratory respiratory JJ cord-302316-raf5rlkq 169 40 distress distress NN cord-302316-raf5rlkq 169 41 syndrome syndrome NN cord-302316-raf5rlkq 169 42 ( ( -LRB- cord-302316-raf5rlkq 169 43 Mah Mah NNP cord-302316-raf5rlkq 169 44 evas evas NNP cord-302316-raf5rlkq 169 45 et et NNP cord-302316-raf5rlkq 169 46 al al NNP cord-302316-raf5rlkq 169 47 . . NNP cord-302316-raf5rlkq 169 48 , , , cord-302316-raf5rlkq 169 49 2020 2020 CD cord-302316-raf5rlkq 169 50 ) ) -RRB- cord-302316-raf5rlkq 169 51 . . . cord-302316-raf5rlkq 170 1 Eighty eighty CD cord-302316-raf5rlkq 170 2 - - HYPH cord-302316-raf5rlkq 170 3 one one CD cord-302316-raf5rlkq 170 4 adult adult NN cord-302316-raf5rlkq 170 5 Brazilian brazilian JJ cord-302316-raf5rlkq 170 6 patients patient NNS cord-302316-raf5rlkq 170 7 with with IN cord-302316-raf5rlkq 170 8 severe severe JJ cord-302316-raf5rlkq 170 9 COVID-19 covid-19 NN cord-302316-raf5rlkq 170 10 were be VBD cord-302316-raf5rlkq 170 11 randomized randomize VBN cord-302316-raf5rlkq 170 12 on on IN cord-302316-raf5rlkq 170 13 a a DT cord-302316-raf5rlkq 170 14 high high JJ cord-302316-raf5rlkq 170 15 or or CC cord-302316-raf5rlkq 170 16 a a DT cord-302316-raf5rlkq 170 17 low low JJ cord-302316-raf5rlkq 170 18 dose dose NN cord-302316-raf5rlkq 170 19 of of IN cord-302316-raf5rlkq 170 20 chloroquine chloroquine NN cord-302316-raf5rlkq 170 21 plus plus CC cord-302316-raf5rlkq 170 22 azithromycin azithromycin NNP cord-302316-raf5rlkq 170 23 and and CC cord-302316-raf5rlkq 170 24 oseltamivir oseltamivir NNP cord-302316-raf5rlkq 170 25 . . . cord-302316-raf5rlkq 171 1 A a DT cord-302316-raf5rlkq 171 2 placebo placebo NN cord-302316-raf5rlkq 171 3 group group NN cord-302316-raf5rlkq 171 4 was be VBD cord-302316-raf5rlkq 171 5 considered consider VBN cord-302316-raf5rlkq 171 6 to to TO cord-302316-raf5rlkq 171 7 have have VB cord-302316-raf5rlkq 171 8 been be VBN cord-302316-raf5rlkq 171 9 unethical unethical JJ cord-302316-raf5rlkq 171 10 due due IN cord-302316-raf5rlkq 171 11 to to IN cord-302316-raf5rlkq 171 12 media medium NNS cord-302316-raf5rlkq 171 13 support support NN cord-302316-raf5rlkq 171 14 for for IN cord-302316-raf5rlkq 171 15 chloroquine chloroquine NN cord-302316-raf5rlkq 171 16 use use NN cord-302316-raf5rlkq 171 17 . . . cord-302316-raf5rlkq 172 1 Overall overall JJ cord-302316-raf5rlkq 172 2 mortality mortality NN cord-302316-raf5rlkq 172 3 was be VBD cord-302316-raf5rlkq 172 4 27 27 CD cord-302316-raf5rlkq 172 5 % % NN cord-302316-raf5rlkq 172 6 , , , cord-302316-raf5rlkq 172 7 which which WDT cord-302316-raf5rlkq 172 8 was be VBD cord-302316-raf5rlkq 172 9 not not RB cord-302316-raf5rlkq 172 10 lower low JJR cord-302316-raf5rlkq 172 11 than than IN cord-302316-raf5rlkq 172 12 in in IN cord-302316-raf5rlkq 172 13 historical historical JJ cord-302316-raf5rlkq 172 14 controls control NNS cord-302316-raf5rlkq 172 15 . . . cord-302316-raf5rlkq 173 1 Mortality mortality NN cord-302316-raf5rlkq 173 2 was be VBD cord-302316-raf5rlkq 173 3 substantially substantially RB cord-302316-raf5rlkq 173 4 higher high JJR cord-302316-raf5rlkq 173 5 in in IN cord-302316-raf5rlkq 173 6 the the DT cord-302316-raf5rlkq 173 7 high high JJ cord-302316-raf5rlkq 173 8 - - HYPH cord-302316-raf5rlkq 173 9 dose dose NN cord-302316-raf5rlkq 173 10 group group NN cord-302316-raf5rlkq 173 11 compared compare VBN cord-302316-raf5rlkq 173 12 with with IN cord-302316-raf5rlkq 173 13 the the DT cord-302316-raf5rlkq 173 14 lowdose lowdose NNP cord-302316-raf5rlkq 173 15 chloroquine chloroquine NNP cord-302316-raf5rlkq 173 16 group group NN cord-302316-raf5rlkq 173 17 ( ( -LRB- cord-302316-raf5rlkq 173 18 39 39 CD cord-302316-raf5rlkq 173 19 vs. vs. CC cord-302316-raf5rlkq 173 20 15 15 CD cord-302316-raf5rlkq 173 21 % % NN cord-302316-raf5rlkq 173 22 ) ) -RRB- cord-302316-raf5rlkq 173 23 , , , cord-302316-raf5rlkq 173 24 and and CC cord-302316-raf5rlkq 173 25 the the DT cord-302316-raf5rlkq 173 26 high high JJ cord-302316-raf5rlkq 173 27 - - HYPH cord-302316-raf5rlkq 173 28 dose dose NN cord-302316-raf5rlkq 173 29 regime regime NN cord-302316-raf5rlkq 173 30 was be VBD cord-302316-raf5rlkq 173 31 stopped stop VBN cord-302316-raf5rlkq 173 32 in in IN cord-302316-raf5rlkq 173 33 this this DT cord-302316-raf5rlkq 173 34 trial trial NN cord-302316-raf5rlkq 173 35 by by IN cord-302316-raf5rlkq 173 36 the the DT cord-302316-raf5rlkq 173 37 data data NN cord-302316-raf5rlkq 173 38 safety safety NNP cord-302316-raf5rlkq 173 39 monitoring monitoring NNP cord-302316-raf5rlkq 173 40 board board NN cord-302316-raf5rlkq 173 41 . . . cord-302316-raf5rlkq 174 1 On on IN cord-302316-raf5rlkq 174 2 day day NN cord-302316-raf5rlkq 174 3 4 4 CD cord-302316-raf5rlkq 174 4 of of IN cord-302316-raf5rlkq 174 5 hospitalization hospitalization NN cord-302316-raf5rlkq 174 6 , , , cord-302316-raf5rlkq 174 7 more more JJR cord-302316-raf5rlkq 174 8 than than IN cord-302316-raf5rlkq 174 9 80 80 CD cord-302316-raf5rlkq 174 10 % % NN cord-302316-raf5rlkq 174 11 of of IN cord-302316-raf5rlkq 174 12 the the DT cord-302316-raf5rlkq 174 13 patients patient NNS cord-302316-raf5rlkq 174 14 in in IN cord-302316-raf5rlkq 174 15 both both DT cord-302316-raf5rlkq 174 16 groups group NNS cord-302316-raf5rlkq 174 17 showed show VBD cord-302316-raf5rlkq 174 18 viral viral JJ cord-302316-raf5rlkq 174 19 RNA RNA NNP cord-302316-raf5rlkq 174 20 in in IN cord-302316-raf5rlkq 174 21 nasopharyngeal nasopharyngeal JJ cord-302316-raf5rlkq 174 22 secretions secretion NNS cord-302316-raf5rlkq 174 23 excluding exclude VBG cord-302316-raf5rlkq 174 24 an an DT cord-302316-raf5rlkq 174 25 antiviral antiviral JJ cord-302316-raf5rlkq 174 26 effect effect NN cord-302316-raf5rlkq 174 27 ( ( -LRB- cord-302316-raf5rlkq 174 28 Borba Borba NNP cord-302316-raf5rlkq 174 29 et et NNP cord-302316-raf5rlkq 174 30 al al NNP cord-302316-raf5rlkq 174 31 . . NNP cord-302316-raf5rlkq 174 32 , , , cord-302316-raf5rlkq 174 33 2020 2020 CD cord-302316-raf5rlkq 174 34 ) ) -RRB- cord-302316-raf5rlkq 174 35 . . . cord-302316-raf5rlkq 175 1 One one CD cord-302316-raf5rlkq 175 2 hundred hundred CD cord-302316-raf5rlkq 175 3 and and CC cord-302316-raf5rlkq 175 4 fifty fifty CD cord-302316-raf5rlkq 175 5 COVID-19 covid-19 CD cord-302316-raf5rlkq 175 6 patients patient NNS cord-302316-raf5rlkq 175 7 from from IN cord-302316-raf5rlkq 175 8 China China NNP cord-302316-raf5rlkq 175 9 were be VBD cord-302316-raf5rlkq 175 10 treated treat VBN cord-302316-raf5rlkq 175 11 with with IN cord-302316-raf5rlkq 175 12 oral oral JJ cord-302316-raf5rlkq 175 13 hydroxychloroquine hydroxychloroquine NN cord-302316-raf5rlkq 175 14 ( ( -LRB- cord-302316-raf5rlkq 175 15 HCQ HCQ NNP cord-302316-raf5rlkq 175 16 ) ) -RRB- cord-302316-raf5rlkq 175 17 , , , cord-302316-raf5rlkq 175 18 and and CC cord-302316-raf5rlkq 175 19 this this DT cord-302316-raf5rlkq 175 20 was be VBD cord-302316-raf5rlkq 175 21 compared compare VBN cord-302316-raf5rlkq 175 22 with with IN cord-302316-raf5rlkq 175 23 standard standard JJ cord-302316-raf5rlkq 175 24 treatment treatment NN cord-302316-raf5rlkq 175 25 alone alone RB cord-302316-raf5rlkq 175 26 in in IN cord-302316-raf5rlkq 175 27 an an DT cord-302316-raf5rlkq 175 28 open open JJ cord-302316-raf5rlkq 175 29 clinical clinical JJ cord-302316-raf5rlkq 175 30 trial trial NN cord-302316-raf5rlkq 175 31 . . . cord-302316-raf5rlkq 176 1 The the DT cord-302316-raf5rlkq 176 2 treatment treatment NN cord-302316-raf5rlkq 176 3 did do VBD cord-302316-raf5rlkq 176 4 not not RB cord-302316-raf5rlkq 176 5 result result VB cord-302316-raf5rlkq 176 6 in in IN cord-302316-raf5rlkq 176 7 an an DT cord-302316-raf5rlkq 176 8 accelerated accelerated JJ cord-302316-raf5rlkq 176 9 clearance clearance NN cord-302316-raf5rlkq 176 10 of of IN cord-302316-raf5rlkq 176 11 viral viral JJ cord-302316-raf5rlkq 176 12 RNA RNA NNP cord-302316-raf5rlkq 176 13 in in IN cord-302316-raf5rlkq 176 14 upper upper JJ cord-302316-raf5rlkq 176 15 and and CC cord-302316-raf5rlkq 176 16 lower low JJR cord-302316-raf5rlkq 176 17 respiratory respiratory JJ cord-302316-raf5rlkq 176 18 tract tract NN cord-302316-raf5rlkq 176 19 secretions secretion NNS cord-302316-raf5rlkq 176 20 . . . cord-302316-raf5rlkq 177 1 Clinical clinical JJ cord-302316-raf5rlkq 177 2 symptom symptom NN cord-302316-raf5rlkq 177 3 alleviation alleviation NN cord-302316-raf5rlkq 177 4 within within IN cord-302316-raf5rlkq 177 5 28 28 CD cord-302316-raf5rlkq 177 6 days day NNS cord-302316-raf5rlkq 177 7 was be VBD cord-302316-raf5rlkq 177 8 not not RB cord-302316-raf5rlkq 177 9 different different JJ cord-302316-raf5rlkq 177 10 between between IN cord-302316-raf5rlkq 177 11 the the DT cord-302316-raf5rlkq 177 12 two two CD cord-302316-raf5rlkq 177 13 groups group NNS cord-302316-raf5rlkq 177 14 . . . cord-302316-raf5rlkq 178 1 A a DT cord-302316-raf5rlkq 178 2 more more RBR cord-302316-raf5rlkq 178 3 rapid rapid JJ cord-302316-raf5rlkq 178 4 symptom symptom NN cord-302316-raf5rlkq 178 5 alleviation alleviation NN cord-302316-raf5rlkq 178 6 was be VBD cord-302316-raf5rlkq 178 7 seen see VBN cord-302316-raf5rlkq 178 8 for for IN cord-302316-raf5rlkq 178 9 HCQ HCQ NNP cord-302316-raf5rlkq 178 10 , , , cord-302316-raf5rlkq 178 11 over over IN cord-302316-raf5rlkq 178 12 the the DT cord-302316-raf5rlkq 178 13 control control NN cord-302316-raf5rlkq 178 14 group group NN cord-302316-raf5rlkq 178 15 during during IN cord-302316-raf5rlkq 178 16 the the DT cord-302316-raf5rlkq 178 17 second second JJ cord-302316-raf5rlkq 178 18 week week NN cord-302316-raf5rlkq 178 19 of of IN cord-302316-raf5rlkq 178 20 treatment treatment NN cord-302316-raf5rlkq 178 21 , , , cord-302316-raf5rlkq 178 22 but but CC cord-302316-raf5rlkq 178 23 it -PRON- PRP cord-302316-raf5rlkq 178 24 was be VBD cord-302316-raf5rlkq 178 25 not not RB cord-302316-raf5rlkq 178 26 statistically statistically RB cord-302316-raf5rlkq 178 27 significant significant JJ cord-302316-raf5rlkq 178 28 . . . cord-302316-raf5rlkq 179 1 This this DT cord-302316-raf5rlkq 179 2 trend trend NN cord-302316-raf5rlkq 179 3 became become VBD cord-302316-raf5rlkq 179 4 even even RB cord-302316-raf5rlkq 179 5 more more RBR cord-302316-raf5rlkq 179 6 visible visible JJ cord-302316-raf5rlkq 179 7 when when WRB cord-302316-raf5rlkq 179 8 in in IN cord-302316-raf5rlkq 179 9 a a DT cord-302316-raf5rlkq 179 10 post post FW cord-302316-raf5rlkq 179 11 hoc hoc FW cord-302316-raf5rlkq 179 12 analysis analysis NN cord-302316-raf5rlkq 179 13 only only RB cord-302316-raf5rlkq 179 14 cases case NNS cord-302316-raf5rlkq 179 15 of of IN cord-302316-raf5rlkq 179 16 patients patient NNS cord-302316-raf5rlkq 179 17 without without IN cord-302316-raf5rlkq 179 18 other other JJ cord-302316-raf5rlkq 179 19 antiviral antiviral JJ cord-302316-raf5rlkq 179 20 agent agent NN cord-302316-raf5rlkq 179 21 treatment treatment NN cord-302316-raf5rlkq 179 22 were be VBD cord-302316-raf5rlkq 179 23 investigated investigate VBN cord-302316-raf5rlkq 179 24 . . . cord-302316-raf5rlkq 180 1 HCQ HCQ NNP cord-302316-raf5rlkq 180 2 led lead VBD cord-302316-raf5rlkq 180 3 to to IN cord-302316-raf5rlkq 180 4 a a DT cord-302316-raf5rlkq 180 5 more more RBR cord-302316-raf5rlkq 180 6 rapid rapid JJ cord-302316-raf5rlkq 180 7 normalization normalization NN cord-302316-raf5rlkq 180 8 of of IN cord-302316-raf5rlkq 180 9 C c NN cord-302316-raf5rlkq 180 10 - - HYPH cord-302316-raf5rlkq 180 11 reactive reactive JJ cord-302316-raf5rlkq 180 12 protein protein NN cord-302316-raf5rlkq 180 13 levels level NNS cord-302316-raf5rlkq 180 14 compared compare VBN cord-302316-raf5rlkq 180 15 with with IN cord-302316-raf5rlkq 180 16 those those DT cord-302316-raf5rlkq 180 17 in in IN cord-302316-raf5rlkq 180 18 the the DT cord-302316-raf5rlkq 180 19 controls control NNS cord-302316-raf5rlkq 180 20 . . . cord-302316-raf5rlkq 181 1 HCQ hcq NN cord-302316-raf5rlkq 181 2 addition addition NN cord-302316-raf5rlkq 181 3 led lead VBD cord-302316-raf5rlkq 181 4 to to IN cord-302316-raf5rlkq 181 5 a a DT cord-302316-raf5rlkq 181 6 higher high JJR cord-302316-raf5rlkq 181 7 rate rate NN cord-302316-raf5rlkq 181 8 of of IN cord-302316-raf5rlkq 181 9 adverse adverse JJ cord-302316-raf5rlkq 181 10 events event NNS cord-302316-raf5rlkq 181 11 over over IN cord-302316-raf5rlkq 181 12 the the DT cord-302316-raf5rlkq 181 13 controls control NNS cord-302316-raf5rlkq 181 14 ( ( -LRB- cord-302316-raf5rlkq 181 15 30 30 CD cord-302316-raf5rlkq 181 16 % % NN cord-302316-raf5rlkq 181 17 vs vs IN cord-302316-raf5rlkq 181 18 9 9 CD cord-302316-raf5rlkq 181 19 % % NN cord-302316-raf5rlkq 181 20 ) ) -RRB- cord-302316-raf5rlkq 181 21 , , , cord-302316-raf5rlkq 181 22 which which WDT cord-302316-raf5rlkq 181 23 consisted consist VBD cord-302316-raf5rlkq 181 24 mostly mostly RB cord-302316-raf5rlkq 181 25 of of IN cord-302316-raf5rlkq 181 26 diarrhoea diarrhoea NN cord-302316-raf5rlkq 182 1 ( ( -LRB- cord-302316-raf5rlkq 182 2 Tang Tang NNP cord-302316-raf5rlkq 182 3 et et FW cord-302316-raf5rlkq 182 4 al al NNP cord-302316-raf5rlkq 182 5 . . NNP cord-302316-raf5rlkq 182 6 , , , cord-302316-raf5rlkq 182 7 2020b 2020b CD cord-302316-raf5rlkq 182 8 ) ) -RRB- cord-302316-raf5rlkq 182 9 . . . cord-302316-raf5rlkq 183 1 From from IN cord-302316-raf5rlkq 183 2 1376 1376 CD cord-302316-raf5rlkq 183 3 consecutive consecutive JJ cord-302316-raf5rlkq 183 4 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 183 5 patients patient NNS cord-302316-raf5rlkq 183 6 hospitalized hospitalize VBN cord-302316-raf5rlkq 183 7 in in IN cord-302316-raf5rlkq 183 8 New New NNP cord-302316-raf5rlkq 183 9 York York NNP cord-302316-raf5rlkq 183 10 City City NNP cord-302316-raf5rlkq 183 11 , , , cord-302316-raf5rlkq 183 12 811 811 CD cord-302316-raf5rlkq 183 13 were be VBD cord-302316-raf5rlkq 183 14 treated treat VBN cord-302316-raf5rlkq 183 15 with with IN cord-302316-raf5rlkq 183 16 a a DT cord-302316-raf5rlkq 183 17 high high JJ cord-302316-raf5rlkq 183 18 dose dose NN cord-302316-raf5rlkq 183 19 of of IN cord-302316-raf5rlkq 183 20 HCQ HCQ NNP cord-302316-raf5rlkq 183 21 on on IN cord-302316-raf5rlkq 183 22 day day NN cord-302316-raf5rlkq 183 23 1 1 CD cord-302316-raf5rlkq 183 24 , , , cord-302316-raf5rlkq 183 25 and and CC cord-302316-raf5rlkq 183 26 a a DT cord-302316-raf5rlkq 183 27 low low JJ cord-302316-raf5rlkq 183 28 dose dose NN cord-302316-raf5rlkq 183 29 during during IN cord-302316-raf5rlkq 183 30 the the DT cord-302316-raf5rlkq 183 31 following following JJ cord-302316-raf5rlkq 183 32 4 4 CD cord-302316-raf5rlkq 183 33 days day NNS cord-302316-raf5rlkq 183 34 . . . cord-302316-raf5rlkq 184 1 Half half NN cord-302316-raf5rlkq 184 2 of of IN cord-302316-raf5rlkq 184 3 them -PRON- PRP cord-302316-raf5rlkq 184 4 received receive VBD cord-302316-raf5rlkq 184 5 the the DT cord-302316-raf5rlkq 184 6 high high JJ cord-302316-raf5rlkq 184 7 dose dose NN cord-302316-raf5rlkq 184 8 within within IN cord-302316-raf5rlkq 184 9 24 24 CD cord-302316-raf5rlkq 184 10 h h NN cord-302316-raf5rlkq 184 11 of of IN cord-302316-raf5rlkq 184 12 hospitalization hospitalization NN cord-302316-raf5rlkq 184 13 , , , cord-302316-raf5rlkq 184 14 and and CC cord-302316-raf5rlkq 184 15 the the DT cord-302316-raf5rlkq 184 16 follow follow NN cord-302316-raf5rlkq 184 17 - - HYPH cord-302316-raf5rlkq 184 18 up up NN cord-302316-raf5rlkq 184 19 course course NN cord-302316-raf5rlkq 184 20 was be VBD cord-302316-raf5rlkq 184 21 for for IN cord-302316-raf5rlkq 184 22 three three CD cord-302316-raf5rlkq 184 23 weeks week NNS cord-302316-raf5rlkq 184 24 . . . cord-302316-raf5rlkq 185 1 There there EX cord-302316-raf5rlkq 185 2 were be VBD cord-302316-raf5rlkq 185 3 565 565 CD cord-302316-raf5rlkq 185 4 COVID-19 covid-19 CD cord-302316-raf5rlkq 185 5 patients patient NNS cord-302316-raf5rlkq 185 6 who who WP cord-302316-raf5rlkq 185 7 did do VBD cord-302316-raf5rlkq 185 8 not not RB cord-302316-raf5rlkq 185 9 receive receive VB cord-302316-raf5rlkq 185 10 HCQ HCQ NNP cord-302316-raf5rlkq 185 11 . . . cord-302316-raf5rlkq 186 1 The the DT cord-302316-raf5rlkq 186 2 primary primary JJ cord-302316-raf5rlkq 186 3 end end NN cord-302316-raf5rlkq 186 4 - - HYPH cord-302316-raf5rlkq 186 5 point point NN cord-302316-raf5rlkq 186 6 was be VBD cord-302316-raf5rlkq 186 7 intubation intubation NN cord-302316-raf5rlkq 186 8 or or CC cord-302316-raf5rlkq 186 9 death death NN cord-302316-raf5rlkq 186 10 , , , cord-302316-raf5rlkq 186 11 which which WDT cord-302316-raf5rlkq 186 12 occurred occur VBD cord-302316-raf5rlkq 186 13 in in IN cord-302316-raf5rlkq 186 14 25 25 CD cord-302316-raf5rlkq 186 15 % % NN cord-302316-raf5rlkq 186 16 of of IN cord-302316-raf5rlkq 186 17 the the DT cord-302316-raf5rlkq 186 18 patients patient NNS cord-302316-raf5rlkq 186 19 . . . cord-302316-raf5rlkq 187 1 In in IN cord-302316-raf5rlkq 187 2 crude crude JJ cord-302316-raf5rlkq 187 3 , , , cord-302316-raf5rlkq 187 4 unadjusted unadjusted JJ cord-302316-raf5rlkq 187 5 analysis analysis NN cord-302316-raf5rlkq 187 6 of of IN cord-302316-raf5rlkq 187 7 this this DT cord-302316-raf5rlkq 187 8 observational observational JJ cord-302316-raf5rlkq 187 9 study study NN cord-302316-raf5rlkq 187 10 , , , cord-302316-raf5rlkq 187 11 HCQ HCQ NNP cord-302316-raf5rlkq 187 12 - - HYPH cord-302316-raf5rlkq 187 13 treated treat VBN cord-302316-raf5rlkq 187 14 patients patient NNS cord-302316-raf5rlkq 187 15 were be VBD cord-302316-raf5rlkq 187 16 2.4 2.4 CD cord-302316-raf5rlkq 187 17 times time NNS cord-302316-raf5rlkq 187 18 more more RBR cord-302316-raf5rlkq 187 19 likely likely JJ cord-302316-raf5rlkq 187 20 to to TO cord-302316-raf5rlkq 187 21 reach reach VB cord-302316-raf5rlkq 187 22 the the DT cord-302316-raf5rlkq 187 23 detrimental detrimental JJ cord-302316-raf5rlkq 187 24 primary primary JJ cord-302316-raf5rlkq 187 25 end end NN cord-302316-raf5rlkq 187 26 - - HYPH cord-302316-raf5rlkq 187 27 point point NN cord-302316-raf5rlkq 187 28 than than IN cord-302316-raf5rlkq 187 29 non non JJ cord-302316-raf5rlkq 187 30 - - JJ cord-302316-raf5rlkq 187 31 treated treat VBN cord-302316-raf5rlkq 187 32 patients patient NNS cord-302316-raf5rlkq 187 33 . . . cord-302316-raf5rlkq 188 1 Since since IN cord-302316-raf5rlkq 188 2 HCQ HCQ NNP cord-302316-raf5rlkq 188 3 - - HYPH cord-302316-raf5rlkq 188 4 treated treat VBN cord-302316-raf5rlkq 188 5 patients patient NNS cord-302316-raf5rlkq 188 6 were be VBD cord-302316-raf5rlkq 188 7 , , , cord-302316-raf5rlkq 188 8 at at IN cord-302316-raf5rlkq 188 9 baseline baseline NN cord-302316-raf5rlkq 188 10 , , , cord-302316-raf5rlkq 188 11 more more RBR cord-302316-raf5rlkq 188 12 severely severely RB cord-302316-raf5rlkq 188 13 ill ill JJ cord-302316-raf5rlkq 188 14 than than IN cord-302316-raf5rlkq 188 15 non non JJ cord-302316-raf5rlkq 188 16 - - JJ cord-302316-raf5rlkq 188 17 treated treat VBN cord-302316-raf5rlkq 188 18 patients patient NNS cord-302316-raf5rlkq 188 19 ( ( -LRB- cord-302316-raf5rlkq 188 20 by by IN cord-302316-raf5rlkq 188 21 oxygenation oxygenation NN cord-302316-raf5rlkq 188 22 index index NN cord-302316-raf5rlkq 188 23 ) ) -RRB- cord-302316-raf5rlkq 188 24 , , , cord-302316-raf5rlkq 188 25 the the DT cord-302316-raf5rlkq 188 26 811 811 CD cord-302316-raf5rlkq 188 27 cases case NNS cord-302316-raf5rlkq 188 28 of of IN cord-302316-raf5rlkq 188 29 HCQ HCQ NNP cord-302316-raf5rlkq 188 30 patients patient NNS cord-302316-raf5rlkq 188 31 were be VBD cord-302316-raf5rlkq 188 32 compared compare VBN cord-302316-raf5rlkq 188 33 in in IN cord-302316-raf5rlkq 188 34 a a DT cord-302316-raf5rlkq 188 35 second second JJ cord-302316-raf5rlkq 188 36 analysis analysis NN cord-302316-raf5rlkq 188 37 to to IN cord-302316-raf5rlkq 188 38 those those DT cord-302316-raf5rlkq 188 39 of of IN cord-302316-raf5rlkq 188 40 274 274 CD cord-302316-raf5rlkq 188 41 better well RBR cord-302316-raf5rlkq 188 42 matched match VBN cord-302316-raf5rlkq 188 43 non non JJ cord-302316-raf5rlkq 188 44 - - JJ cord-302316-raf5rlkq 188 45 treated treat VBN cord-302316-raf5rlkq 188 46 patients patient NNS cord-302316-raf5rlkq 188 47 . . . cord-302316-raf5rlkq 189 1 Neither neither DT cord-302316-raf5rlkq 189 2 benefit benefit NN cord-302316-raf5rlkq 189 3 nor nor CC cord-302316-raf5rlkq 189 4 harm harm NN cord-302316-raf5rlkq 189 5 has have VBZ cord-302316-raf5rlkq 189 6 been be VBN cord-302316-raf5rlkq 189 7 associated associate VBN cord-302316-raf5rlkq 189 8 with with IN cord-302316-raf5rlkq 189 9 HCQ HCQ NNP cord-302316-raf5rlkq 189 10 use use NN cord-302316-raf5rlkq 189 11 ( ( -LRB- cord-302316-raf5rlkq 189 12 Geleris Geleris NNP cord-302316-raf5rlkq 189 13 et et NNP cord-302316-raf5rlkq 189 14 al al NNP cord-302316-raf5rlkq 189 15 . . NNP cord-302316-raf5rlkq 189 16 , , , cord-302316-raf5rlkq 189 17 2020 2020 CD cord-302316-raf5rlkq 189 18 ) ) -RRB- cord-302316-raf5rlkq 189 19 . . . cord-302316-raf5rlkq 190 1 In in IN cord-302316-raf5rlkq 190 2 an an DT cord-302316-raf5rlkq 190 3 open open JJ cord-302316-raf5rlkq 190 4 - - HYPH cord-302316-raf5rlkq 190 5 label label NN cord-302316-raf5rlkq 190 6 and and CC cord-302316-raf5rlkq 190 7 compassionate compassionate JJ cord-302316-raf5rlkq 190 8 trial trial NN cord-302316-raf5rlkq 190 9 , , , cord-302316-raf5rlkq 190 10 53 53 CD cord-302316-raf5rlkq 190 11 patients patient NNS cord-302316-raf5rlkq 190 12 with with IN cord-302316-raf5rlkq 190 13 severe severe JJ cord-302316-raf5rlkq 190 14 COVID-19 covid-19 NN cord-302316-raf5rlkq 190 15 , , , cord-302316-raf5rlkq 190 16 in in IN cord-302316-raf5rlkq 190 17 which which WDT cord-302316-raf5rlkq 190 18 34 34 CD cord-302316-raf5rlkq 190 19 of of IN cord-302316-raf5rlkq 190 20 them -PRON- PRP cord-302316-raf5rlkq 190 21 were be VBD cord-302316-raf5rlkq 190 22 on on IN cord-302316-raf5rlkq 190 23 invasive invasive JJ cord-302316-raf5rlkq 190 24 ventilation ventilation NN cord-302316-raf5rlkq 190 25 and and CC cord-302316-raf5rlkq 190 26 received receive VBD cord-302316-raf5rlkq 190 27 remdesivir remdesivir NNP cord-302316-raf5rlkq 190 28 , , , cord-302316-raf5rlkq 190 29 a a DT cord-302316-raf5rlkq 190 30 nucleotide nucleotide JJ cord-302316-raf5rlkq 190 31 analogue analogue NN cord-302316-raf5rlkq 190 32 developed develop VBN cord-302316-raf5rlkq 190 33 against against IN cord-302316-raf5rlkq 190 34 Ebola Ebola NNP cord-302316-raf5rlkq 190 35 virus virus NN cord-302316-raf5rlkq 190 36 . . . cord-302316-raf5rlkq 191 1 After after IN cord-302316-raf5rlkq 191 2 3 3 CD cord-302316-raf5rlkq 191 3 weeks week NNS cord-302316-raf5rlkq 191 4 of of IN cord-302316-raf5rlkq 191 5 follow follow NN cord-302316-raf5rlkq 191 6 - - HYPH cord-302316-raf5rlkq 191 7 up up NN cord-302316-raf5rlkq 191 8 , , , cord-302316-raf5rlkq 191 9 68 68 CD cord-302316-raf5rlkq 191 10 % % NN cord-302316-raf5rlkq 191 11 of of IN cord-302316-raf5rlkq 191 12 them -PRON- PRP cord-302316-raf5rlkq 191 13 showed show VBD cord-302316-raf5rlkq 191 14 clinical clinical JJ cord-302316-raf5rlkq 191 15 improvement improvement NN cord-302316-raf5rlkq 191 16 ; ; : cord-302316-raf5rlkq 191 17 57 57 CD cord-302316-raf5rlkq 191 18 % % NN cord-302316-raf5rlkq 191 19 of of IN cord-302316-raf5rlkq 191 20 patients patient NNS cord-302316-raf5rlkq 191 21 on on IN cord-302316-raf5rlkq 191 22 mechanical mechanical JJ cord-302316-raf5rlkq 191 23 ventilation ventilation NN cord-302316-raf5rlkq 191 24 were be VBD cord-302316-raf5rlkq 191 25 extubated extubate VBN cord-302316-raf5rlkq 191 26 , , , cord-302316-raf5rlkq 191 27 while while IN cord-302316-raf5rlkq 191 28 13 13 CD cord-302316-raf5rlkq 191 29 % % NN cord-302316-raf5rlkq 191 30 died die VBD cord-302316-raf5rlkq 191 31 . . . cord-302316-raf5rlkq 192 1 This this DT cord-302316-raf5rlkq 192 2 fatality fatality NN cord-302316-raf5rlkq 192 3 rate rate NN cord-302316-raf5rlkq 192 4 is be VBZ cord-302316-raf5rlkq 192 5 a a DT cord-302316-raf5rlkq 192 6 relatively relatively RB cord-302316-raf5rlkq 192 7 better well JJR cord-302316-raf5rlkq 192 8 result result NN cord-302316-raf5rlkq 192 9 when when WRB cord-302316-raf5rlkq 192 10 compared compare VBN cord-302316-raf5rlkq 192 11 with with IN cord-302316-raf5rlkq 192 12 a a DT cord-302316-raf5rlkq 192 13 66 66 CD cord-302316-raf5rlkq 192 14 % % NN cord-302316-raf5rlkq 192 15 mortality mortality NN cord-302316-raf5rlkq 192 16 rate rate NN cord-302316-raf5rlkq 192 17 in in IN cord-302316-raf5rlkq 192 18 Chinese chinese JJ cord-302316-raf5rlkq 192 19 patients patient NNS cord-302316-raf5rlkq 192 20 receiving receive VBG cord-302316-raf5rlkq 192 21 invasive invasive JJ cord-302316-raf5rlkq 192 22 ventilation ventilation NN cord-302316-raf5rlkq 192 23 . . . cord-302316-raf5rlkq 193 1 Due due IN cord-302316-raf5rlkq 193 2 to to IN cord-302316-raf5rlkq 193 3 a a DT cord-302316-raf5rlkq 193 4 small small JJ cord-302316-raf5rlkq 193 5 study study NN cord-302316-raf5rlkq 193 6 size size NN cord-302316-raf5rlkq 193 7 , , , cord-302316-raf5rlkq 193 8 short short JJ cord-302316-raf5rlkq 193 9 length length NN cord-302316-raf5rlkq 193 10 of of IN cord-302316-raf5rlkq 193 11 follow follow NN cord-302316-raf5rlkq 193 12 - - HYPH cord-302316-raf5rlkq 193 13 up up NN cord-302316-raf5rlkq 193 14 and and CC cord-302316-raf5rlkq 193 15 the the DT cord-302316-raf5rlkq 193 16 lack lack NN cord-302316-raf5rlkq 193 17 of of IN cord-302316-raf5rlkq 193 18 a a DT cord-302316-raf5rlkq 193 19 randomized randomized JJ cord-302316-raf5rlkq 193 20 control control NN cord-302316-raf5rlkq 193 21 group group NN cord-302316-raf5rlkq 193 22 , , , cord-302316-raf5rlkq 193 23 the the DT cord-302316-raf5rlkq 193 24 outcome outcome NN cord-302316-raf5rlkq 193 25 must must MD cord-302316-raf5rlkq 193 26 be be VB cord-302316-raf5rlkq 193 27 interpreted interpret VBN cord-302316-raf5rlkq 193 28 with with IN cord-302316-raf5rlkq 193 29 caution caution NN cord-302316-raf5rlkq 193 30 ( ( -LRB- cord-302316-raf5rlkq 193 31 Grein Grein NNP cord-302316-raf5rlkq 193 32 et et NNP cord-302316-raf5rlkq 193 33 al al NNP cord-302316-raf5rlkq 193 34 . . NNP cord-302316-raf5rlkq 193 35 , , , cord-302316-raf5rlkq 193 36 2020 2020 CD cord-302316-raf5rlkq 193 37 ) ) -RRB- cord-302316-raf5rlkq 193 38 . . . cord-302316-raf5rlkq 194 1 In in IN cord-302316-raf5rlkq 194 2 Hubei Hubei NNP cord-302316-raf5rlkq 194 3 , , , cord-302316-raf5rlkq 194 4 there there EX cord-302316-raf5rlkq 194 5 were be VBD cord-302316-raf5rlkq 194 6 237 237 CD cord-302316-raf5rlkq 194 7 Chinese chinese JJ cord-302316-raf5rlkq 194 8 patients patient NNS cord-302316-raf5rlkq 194 9 with with IN cord-302316-raf5rlkq 194 10 severe severe JJ cord-302316-raf5rlkq 194 11 COVID-19 covid-19 NN cord-302316-raf5rlkq 194 12 who who WP cord-302316-raf5rlkq 194 13 were be VBD cord-302316-raf5rlkq 194 14 subsequently subsequently RB cord-302316-raf5rlkq 194 15 randomized randomize VBN cord-302316-raf5rlkq 194 16 on on IN cord-302316-raf5rlkq 194 17 a a DT cord-302316-raf5rlkq 194 18 2:1 2:1 CD cord-302316-raf5rlkq 194 19 basis basis NN cord-302316-raf5rlkq 194 20 for for IN cord-302316-raf5rlkq 194 21 intravenous intravenous JJ cord-302316-raf5rlkq 194 22 remdesivir remdesivir NNP cord-302316-raf5rlkq 194 23 , , , cord-302316-raf5rlkq 194 24 or or CC cord-302316-raf5rlkq 194 25 placebo placebo NN cord-302316-raf5rlkq 194 26 , , , cord-302316-raf5rlkq 194 27 in in IN cord-302316-raf5rlkq 194 28 a a DT cord-302316-raf5rlkq 194 29 multicentre multicentre NNP cord-302316-raf5rlkq 194 30 clinical clinical JJ cord-302316-raf5rlkq 194 31 trial trial NN cord-302316-raf5rlkq 194 32 . . . cord-302316-raf5rlkq 195 1 The the DT cord-302316-raf5rlkq 195 2 time time NN cord-302316-raf5rlkq 195 3 it -PRON- PRP cord-302316-raf5rlkq 195 4 took take VBD cord-302316-raf5rlkq 195 5 to to TO cord-302316-raf5rlkq 195 6 show show VB cord-302316-raf5rlkq 195 7 clinical clinical JJ cord-302316-raf5rlkq 195 8 improvement improvement NN cord-302316-raf5rlkq 195 9 in in IN cord-302316-raf5rlkq 195 10 the the DT cord-302316-raf5rlkq 195 11 remdesivir remdesivir NNP cord-302316-raf5rlkq 195 12 group group NN cord-302316-raf5rlkq 195 13 was be VBD cord-302316-raf5rlkq 195 14 statistically statistically RB cord-302316-raf5rlkq 195 15 not not RB cord-302316-raf5rlkq 195 16 significantly significantly RB cord-302316-raf5rlkq 195 17 different different JJ cord-302316-raf5rlkq 195 18 from from IN cord-302316-raf5rlkq 195 19 that that DT cord-302316-raf5rlkq 195 20 of of IN cord-302316-raf5rlkq 195 21 the the DT cord-302316-raf5rlkq 195 22 control control NN cord-302316-raf5rlkq 195 23 group group NN cord-302316-raf5rlkq 195 24 ( ( -LRB- cord-302316-raf5rlkq 195 25 median median NN cord-302316-raf5rlkq 195 26 21 21 CD cord-302316-raf5rlkq 195 27 vs. vs. NN cord-302316-raf5rlkq 195 28 23 23 CD cord-302316-raf5rlkq 195 29 days day NNS cord-302316-raf5rlkq 195 30 ) ) -RRB- cord-302316-raf5rlkq 195 31 . . . cord-302316-raf5rlkq 196 1 The the DT cord-302316-raf5rlkq 196 2 time time NN cord-302316-raf5rlkq 196 3 from from IN cord-302316-raf5rlkq 196 4 onset onset NN cord-302316-raf5rlkq 196 5 of of IN cord-302316-raf5rlkq 196 6 symptoms symptom NNS cord-302316-raf5rlkq 196 7 to to TO cord-302316-raf5rlkq 196 8 start start VB cord-302316-raf5rlkq 196 9 of of IN cord-302316-raf5rlkq 196 10 treatment treatment NN cord-302316-raf5rlkq 196 11 was be VBD cord-302316-raf5rlkq 196 12 10 10 CD cord-302316-raf5rlkq 196 13 days day NNS cord-302316-raf5rlkq 196 14 . . . cord-302316-raf5rlkq 197 1 Patients patient NNS cord-302316-raf5rlkq 197 2 receiving receive VBG cord-302316-raf5rlkq 197 3 the the DT cord-302316-raf5rlkq 197 4 treatment treatment NN cord-302316-raf5rlkq 197 5 during during IN cord-302316-raf5rlkq 197 6 the the DT cord-302316-raf5rlkq 197 7 first first JJ cord-302316-raf5rlkq 197 8 9 9 CD cord-302316-raf5rlkq 197 9 days day NNS cord-302316-raf5rlkq 197 10 showed show VBD cord-302316-raf5rlkq 197 11 a a DT cord-302316-raf5rlkq 197 12 numerically numerically RB cord-302316-raf5rlkq 197 13 greater great JJR cord-302316-raf5rlkq 197 14 difference difference NN cord-302316-raf5rlkq 197 15 for for IN cord-302316-raf5rlkq 197 16 clinical clinical JJ cord-302316-raf5rlkq 197 17 improvement improvement NN cord-302316-raf5rlkq 197 18 ( ( -LRB- cord-302316-raf5rlkq 197 19 18 18 CD cord-302316-raf5rlkq 197 20 vs. vs. IN cord-302316-raf5rlkq 197 21 Covid-19 covid-19 NN cord-302316-raf5rlkq 197 22 : : : cord-302316-raf5rlkq 197 23 Pathogenesis pathogenesis NN cord-302316-raf5rlkq 197 24 and and CC cord-302316-raf5rlkq 197 25 drugs drug NNS cord-302316-raf5rlkq 197 26 5 5 CD cord-302316-raf5rlkq 197 27 23 23 CD cord-302316-raf5rlkq 197 28 days day NNS cord-302316-raf5rlkq 197 29 ) ) -RRB- cord-302316-raf5rlkq 197 30 , , , cord-302316-raf5rlkq 197 31 but but CC cord-302316-raf5rlkq 197 32 this this DT cord-302316-raf5rlkq 197 33 difference difference NN cord-302316-raf5rlkq 197 34 is be VBZ cord-302316-raf5rlkq 197 35 not not RB cord-302316-raf5rlkq 197 36 statistically statistically RB cord-302316-raf5rlkq 197 37 significant significant JJ cord-302316-raf5rlkq 197 38 . . . cord-302316-raf5rlkq 198 1 The the DT cord-302316-raf5rlkq 198 2 length length NN cord-302316-raf5rlkq 198 3 of of IN cord-302316-raf5rlkq 198 4 time time NN cord-302316-raf5rlkq 198 5 of of IN cord-302316-raf5rlkq 198 6 viral viral JJ cord-302316-raf5rlkq 198 7 excretion excretion NN cord-302316-raf5rlkq 198 8 in in IN cord-302316-raf5rlkq 198 9 upper upper JJ cord-302316-raf5rlkq 198 10 and and CC cord-302316-raf5rlkq 198 11 lower low JJR cord-302316-raf5rlkq 198 12 respiratory respiratory JJ cord-302316-raf5rlkq 198 13 tract tract NN cord-302316-raf5rlkq 198 14 samples sample NNS cord-302316-raf5rlkq 198 15 did do VBD cord-302316-raf5rlkq 198 16 not not RB cord-302316-raf5rlkq 198 17 differ differ VB cord-302316-raf5rlkq 198 18 between between IN cord-302316-raf5rlkq 198 19 the the DT cord-302316-raf5rlkq 198 20 two two CD cord-302316-raf5rlkq 198 21 groups group NNS cord-302316-raf5rlkq 198 22 , , , cord-302316-raf5rlkq 198 23 demonstrating demonstrate VBG cord-302316-raf5rlkq 198 24 a a DT cord-302316-raf5rlkq 198 25 lack lack NN cord-302316-raf5rlkq 198 26 of of IN cord-302316-raf5rlkq 198 27 in in IN cord-302316-raf5rlkq 198 28 vivo vivo NN cord-302316-raf5rlkq 198 29 antiviral antiviral JJ cord-302316-raf5rlkq 198 30 activity activity NN cord-302316-raf5rlkq 198 31 of of IN cord-302316-raf5rlkq 198 32 this this DT cord-302316-raf5rlkq 198 33 nucleoside nucleoside NN cord-302316-raf5rlkq 198 34 analog analog NN cord-302316-raf5rlkq 198 35 . . . cord-302316-raf5rlkq 199 1 The the DT cord-302316-raf5rlkq 199 2 mortality mortality NN cord-302316-raf5rlkq 199 3 rate rate NN cord-302316-raf5rlkq 199 4 was be VBD cord-302316-raf5rlkq 199 5 15 15 CD cord-302316-raf5rlkq 199 6 % % NN cord-302316-raf5rlkq 199 7 in in IN cord-302316-raf5rlkq 199 8 the the DT cord-302316-raf5rlkq 199 9 remdesivir remdesivir NNP cord-302316-raf5rlkq 199 10 group group NN cord-302316-raf5rlkq 199 11 , , , cord-302316-raf5rlkq 199 12 and and CC cord-302316-raf5rlkq 199 13 13 13 CD cord-302316-raf5rlkq 199 14 % % NN cord-302316-raf5rlkq 199 15 in in IN cord-302316-raf5rlkq 199 16 the the DT cord-302316-raf5rlkq 199 17 placebo placebo NN cord-302316-raf5rlkq 199 18 group group NN cord-302316-raf5rlkq 199 19 . . . cord-302316-raf5rlkq 200 1 This this DT cord-302316-raf5rlkq 200 2 otherwise otherwise RB cord-302316-raf5rlkq 200 3 well well RB cord-302316-raf5rlkq 200 4 - - HYPH cord-302316-raf5rlkq 200 5 conducted conduct VBN cord-302316-raf5rlkq 200 6 clinical clinical JJ cord-302316-raf5rlkq 200 7 trial trial NN cord-302316-raf5rlkq 200 8 was be VBD cord-302316-raf5rlkq 200 9 underpowered underpowere VBN cord-302316-raf5rlkq 200 10 because because IN cord-302316-raf5rlkq 200 11 it -PRON- PRP cord-302316-raf5rlkq 200 12 could could MD cord-302316-raf5rlkq 200 13 not not RB cord-302316-raf5rlkq 200 14 attain attain VB cord-302316-raf5rlkq 200 15 the the DT cord-302316-raf5rlkq 200 16 enrolment enrolment NN cord-302316-raf5rlkq 200 17 of of IN cord-302316-raf5rlkq 200 18 the the DT cord-302316-raf5rlkq 200 19 planned planned JJ cord-302316-raf5rlkq 200 20 453 453 CD cord-302316-raf5rlkq 200 21 patients patient NNS cord-302316-raf5rlkq 200 22 , , , cord-302316-raf5rlkq 200 23 since since IN cord-302316-raf5rlkq 200 24 the the DT cord-302316-raf5rlkq 200 25 epidemic epidemic NN cord-302316-raf5rlkq 200 26 stopped stop VBD cord-302316-raf5rlkq 200 27 in in IN cord-302316-raf5rlkq 200 28 Hubei Hubei NNP cord-302316-raf5rlkq 200 29 as as IN cord-302316-raf5rlkq 200 30 a a DT cord-302316-raf5rlkq 200 31 consequence consequence NN cord-302316-raf5rlkq 200 32 of of IN cord-302316-raf5rlkq 200 33 containment containment NN cord-302316-raf5rlkq 200 34 measures measure NNS cord-302316-raf5rlkq 200 35 . . . cord-302316-raf5rlkq 201 1 Both both DT cord-302316-raf5rlkq 201 2 groups group NNS cord-302316-raf5rlkq 201 3 did do VBD cord-302316-raf5rlkq 201 4 not not RB cord-302316-raf5rlkq 201 5 differ differ VB cord-302316-raf5rlkq 201 6 in in IN cord-302316-raf5rlkq 201 7 the the DT cord-302316-raf5rlkq 201 8 types type NNS cord-302316-raf5rlkq 201 9 of of IN cord-302316-raf5rlkq 201 10 , , , cord-302316-raf5rlkq 201 11 or or CC cord-302316-raf5rlkq 201 12 number number NN cord-302316-raf5rlkq 201 13 of of IN cord-302316-raf5rlkq 201 14 adverse adverse JJ cord-302316-raf5rlkq 201 15 events event NNS cord-302316-raf5rlkq 201 16 , , , cord-302316-raf5rlkq 201 17 demonstrating demonstrate VBG cord-302316-raf5rlkq 201 18 the the DT cord-302316-raf5rlkq 201 19 safety safety NN cord-302316-raf5rlkq 201 20 of of IN cord-302316-raf5rlkq 201 21 intravenous intravenous JJ cord-302316-raf5rlkq 201 22 remdesivir remdesivir NNP cord-302316-raf5rlkq 201 23 . . . cord-302316-raf5rlkq 202 1 On on IN cord-302316-raf5rlkq 202 2 1 1 CD cord-302316-raf5rlkq 202 3 May May NNP cord-302316-raf5rlkq 202 4 , , , cord-302316-raf5rlkq 202 5 the the DT cord-302316-raf5rlkq 202 6 FDA FDA NNP cord-302316-raf5rlkq 202 7 granted grant VBD cord-302316-raf5rlkq 202 8 an an DT cord-302316-raf5rlkq 202 9 emergency emergency NN cord-302316-raf5rlkq 202 10 use use NN cord-302316-raf5rlkq 202 11 authorization authorization NN cord-302316-raf5rlkq 202 12 for for IN cord-302316-raf5rlkq 202 13 remdesivir remdesivir NNP cord-302316-raf5rlkq 202 14 to to IN cord-302316-raf5rlkq 202 15 physicians physician NNS cord-302316-raf5rlkq 202 16 . . . cord-302316-raf5rlkq 203 1 The the DT cord-302316-raf5rlkq 203 2 decision decision NN cord-302316-raf5rlkq 203 3 was be VBD cord-302316-raf5rlkq 203 4 based base VBN cord-302316-raf5rlkq 203 5 on on IN cord-302316-raf5rlkq 203 6 the the DT cord-302316-raf5rlkq 203 7 outcome outcome NN cord-302316-raf5rlkq 203 8 of of IN cord-302316-raf5rlkq 203 9 a a DT cord-302316-raf5rlkq 203 10 clinical clinical JJ cord-302316-raf5rlkq 203 11 trial trial NN cord-302316-raf5rlkq 203 12 , , , cord-302316-raf5rlkq 203 13 which which WDT cord-302316-raf5rlkq 203 14 showed show VBD cord-302316-raf5rlkq 203 15 an an DT cord-302316-raf5rlkq 203 16 accelerated accelerate VBN cord-302316-raf5rlkq 203 17 recovery recovery NN cord-302316-raf5rlkq 203 18 in in IN cord-302316-raf5rlkq 203 19 more more JJR cord-302316-raf5rlkq 203 20 than than IN cord-302316-raf5rlkq 203 21 1000 1000 CD cord-302316-raf5rlkq 203 22 enrolled enrol VBN cord-302316-raf5rlkq 203 23 patients patient NNS cord-302316-raf5rlkq 203 24 treated treat VBN cord-302316-raf5rlkq 203 25 with with IN cord-302316-raf5rlkq 203 26 either either DT cord-302316-raf5rlkq 203 27 remdesivir remdesivir NNS cord-302316-raf5rlkq 203 28 or or CC cord-302316-raf5rlkq 203 29 placebo placebo NN cord-302316-raf5rlkq 203 30 ( ( -LRB- cord-302316-raf5rlkq 203 31 11 11 CD cord-302316-raf5rlkq 203 32 vs. vs. CC cord-302316-raf5rlkq 203 33 15 15 CD cord-302316-raf5rlkq 203 34 days day NNS cord-302316-raf5rlkq 203 35 ) ) -RRB- cord-302316-raf5rlkq 203 36 . . . cord-302316-raf5rlkq 204 1 There there EX cord-302316-raf5rlkq 204 2 were be VBD cord-302316-raf5rlkq 204 3 fewer few JJR cord-302316-raf5rlkq 204 4 deaths death NNS cord-302316-raf5rlkq 204 5 in in IN cord-302316-raf5rlkq 204 6 the the DT cord-302316-raf5rlkq 204 7 group group NN cord-302316-raf5rlkq 204 8 with with IN cord-302316-raf5rlkq 204 9 treatment treatment NN cord-302316-raf5rlkq 204 10 than than IN cord-302316-raf5rlkq 204 11 in in IN cord-302316-raf5rlkq 204 12 the the DT cord-302316-raf5rlkq 204 13 placebo placebo NN cord-302316-raf5rlkq 204 14 group group NN cord-302316-raf5rlkq 204 15 , , , cord-302316-raf5rlkq 204 16 but but CC cord-302316-raf5rlkq 204 17 the the DT cord-302316-raf5rlkq 204 18 difference difference NN cord-302316-raf5rlkq 204 19 was be VBD cord-302316-raf5rlkq 204 20 not not RB cord-302316-raf5rlkq 204 21 statistically statistically RB cord-302316-raf5rlkq 204 22 significant significant JJ cord-302316-raf5rlkq 204 23 . . . cord-302316-raf5rlkq 205 1 Details detail NNS cord-302316-raf5rlkq 205 2 of of IN cord-302316-raf5rlkq 205 3 the the DT cord-302316-raf5rlkq 205 4 trial trial NN cord-302316-raf5rlkq 205 5 have have VBP cord-302316-raf5rlkq 205 6 not not RB cord-302316-raf5rlkq 205 7 yet yet RB cord-302316-raf5rlkq 205 8 been be VBN cord-302316-raf5rlkq 205 9 published publish VBN cord-302316-raf5rlkq 205 10 ( ( -LRB- cord-302316-raf5rlkq 205 11 Ledford Ledford NNP cord-302316-raf5rlkq 205 12 , , , cord-302316-raf5rlkq 205 13 2020 2020 CD cord-302316-raf5rlkq 205 14 ) ) -RRB- cord-302316-raf5rlkq 205 15 . . . cord-302316-raf5rlkq 206 1 A a DT cord-302316-raf5rlkq 206 2 total total NN cord-302316-raf5rlkq 206 3 of of IN cord-302316-raf5rlkq 206 4 86 86 CD cord-302316-raf5rlkq 206 5 COVID-19 covid-19 CD cord-302316-raf5rlkq 206 6 cases case NNS cord-302316-raf5rlkq 206 7 of of IN cord-302316-raf5rlkq 206 8 patients patient NNS cord-302316-raf5rlkq 206 9 from from IN cord-302316-raf5rlkq 206 10 China China NNP cord-302316-raf5rlkq 206 11 with with IN cord-302316-raf5rlkq 206 12 mild mild JJ cord-302316-raf5rlkq 206 13 / / SYM cord-302316-raf5rlkq 206 14 moderate moderate JJ cord-302316-raf5rlkq 206 15 disease disease NN cord-302316-raf5rlkq 206 16 were be VBD cord-302316-raf5rlkq 206 17 randomized randomize VBN cord-302316-raf5rlkq 206 18 on on IN cord-302316-raf5rlkq 206 19 the the DT cord-302316-raf5rlkq 206 20 antiviral antiviral JJ cord-302316-raf5rlkq 206 21 lopinavir lopinavir NNS cord-302316-raf5rlkq 206 22 ( ( -LRB- cord-302316-raf5rlkq 206 23 an an DT cord-302316-raf5rlkq 206 24 inhibitor inhibitor NN cord-302316-raf5rlkq 206 25 of of IN cord-302316-raf5rlkq 206 26 HIV HIV NNP cord-302316-raf5rlkq 206 27 protease protease NN cord-302316-raf5rlkq 206 28 combined combine VBN cord-302316-raf5rlkq 206 29 with with IN cord-302316-raf5rlkq 206 30 ritonavir ritonavir NNS cord-302316-raf5rlkq 206 31 , , , cord-302316-raf5rlkq 206 32 which which WDT cord-302316-raf5rlkq 206 33 prolongs prolong VBZ cord-302316-raf5rlkq 206 34 the the DT cord-302316-raf5rlkq 206 35 presence presence NN cord-302316-raf5rlkq 206 36 of of IN cord-302316-raf5rlkq 206 37 drugs drug NNS cord-302316-raf5rlkq 206 38 in in IN cord-302316-raf5rlkq 206 39 the the DT cord-302316-raf5rlkq 206 40 body body NN cord-302316-raf5rlkq 206 41 ) ) -RRB- cord-302316-raf5rlkq 206 42 or or CC cord-302316-raf5rlkq 206 43 the the DT cord-302316-raf5rlkq 206 44 antiviral antiviral JJ cord-302316-raf5rlkq 206 45 arbidol arbidol NN cord-302316-raf5rlkq 206 46 ( ( -LRB- cord-302316-raf5rlkq 206 47 an an DT cord-302316-raf5rlkq 206 48 influenza influenza NN cord-302316-raf5rlkq 206 49 virus virus NN cord-302316-raf5rlkq 206 50 fusion fusion NN cord-302316-raf5rlkq 206 51 inhibitor inhibitor NN cord-302316-raf5rlkq 206 52 only only RB cord-302316-raf5rlkq 206 53 registered register VBN cord-302316-raf5rlkq 206 54 in in IN cord-302316-raf5rlkq 206 55 Russia Russia NNP cord-302316-raf5rlkq 206 56 ) ) -RRB- cord-302316-raf5rlkq 206 57 or or CC cord-302316-raf5rlkq 206 58 in in IN cord-302316-raf5rlkq 206 59 a a DT cord-302316-raf5rlkq 206 60 control control NN cord-302316-raf5rlkq 206 61 group group NN cord-302316-raf5rlkq 206 62 in in IN cord-302316-raf5rlkq 206 63 a a DT cord-302316-raf5rlkq 206 64 2:2:1 2:2:1 CD cord-302316-raf5rlkq 206 65 ratio ratio NN cord-302316-raf5rlkq 206 66 . . . cord-302316-raf5rlkq 207 1 The the DT cord-302316-raf5rlkq 207 2 primary primary JJ cord-302316-raf5rlkq 207 3 end end NN cord-302316-raf5rlkq 207 4 - - HYPH cord-302316-raf5rlkq 207 5 point point NN cord-302316-raf5rlkq 207 6 was be VBD cord-302316-raf5rlkq 207 7 positive positive JJ cord-302316-raf5rlkq 207 8 - - HYPH cord-302316-raf5rlkq 207 9 to to IN cord-302316-raf5rlkq 207 10 - - HYPH cord-302316-raf5rlkq 207 11 negative negative JJ cord-302316-raf5rlkq 207 12 conversion conversion NN cord-302316-raf5rlkq 207 13 for for IN cord-302316-raf5rlkq 207 14 viral viral JJ cord-302316-raf5rlkq 207 15 RNA RNA NNP cord-302316-raf5rlkq 207 16 in in IN cord-302316-raf5rlkq 207 17 pharyngeal pharyngeal JJ cord-302316-raf5rlkq 207 18 swabs swab NNS cord-302316-raf5rlkq 207 19 . . . cord-302316-raf5rlkq 208 1 No no DT cord-302316-raf5rlkq 208 2 difference difference NN cord-302316-raf5rlkq 208 3 was be VBD cord-302316-raf5rlkq 208 4 seen see VBN cord-302316-raf5rlkq 208 5 between between IN cord-302316-raf5rlkq 208 6 the the DT cord-302316-raf5rlkq 208 7 groups group NNS cord-302316-raf5rlkq 208 8 . . . cord-302316-raf5rlkq 209 1 Secondary secondary JJ cord-302316-raf5rlkq 209 2 outcomes outcome NNS cord-302316-raf5rlkq 209 3 were be VBD cord-302316-raf5rlkq 209 4 represented represent VBN cord-302316-raf5rlkq 209 5 by by IN cord-302316-raf5rlkq 209 6 clinical clinical JJ cord-302316-raf5rlkq 209 7 parameters parameter NNS cord-302316-raf5rlkq 209 8 : : : cord-302316-raf5rlkq 209 9 fever fever NN cord-302316-raf5rlkq 209 10 , , , cord-302316-raf5rlkq 209 11 cough cough NN cord-302316-raf5rlkq 209 12 and and CC cord-302316-raf5rlkq 209 13 lung lung NN cord-302316-raf5rlkq 209 14 CT CT NNP cord-302316-raf5rlkq 209 15 improvement improvement NN cord-302316-raf5rlkq 209 16 . . . cord-302316-raf5rlkq 210 1 Again again RB cord-302316-raf5rlkq 210 2 , , , cord-302316-raf5rlkq 210 3 no no DT cord-302316-raf5rlkq 210 4 difference difference NN cord-302316-raf5rlkq 210 5 was be VBD cord-302316-raf5rlkq 210 6 seen see VBN cord-302316-raf5rlkq 210 7 between between IN cord-302316-raf5rlkq 210 8 the the DT cord-302316-raf5rlkq 210 9 groups group NNS cord-302316-raf5rlkq 210 10 . . . cord-302316-raf5rlkq 211 1 Adverse adverse JJ cord-302316-raf5rlkq 211 2 events event NNS cord-302316-raf5rlkq 211 3 were be VBD cord-302316-raf5rlkq 211 4 not not RB cord-302316-raf5rlkq 211 5 observed observe VBN cord-302316-raf5rlkq 211 6 in in IN cord-302316-raf5rlkq 211 7 the the DT cord-302316-raf5rlkq 211 8 controls control NNS cord-302316-raf5rlkq 211 9 , , , cord-302316-raf5rlkq 211 10 but but CC cord-302316-raf5rlkq 211 11 in in IN cord-302316-raf5rlkq 211 12 35 35 CD cord-302316-raf5rlkq 211 13 % % NN cord-302316-raf5rlkq 211 14 and and CC cord-302316-raf5rlkq 211 15 14 14 CD cord-302316-raf5rlkq 211 16 % % NN cord-302316-raf5rlkq 211 17 of of IN cord-302316-raf5rlkq 211 18 the the DT cord-302316-raf5rlkq 211 19 lopinavir lopinavir NNS cord-302316-raf5rlkq 211 20 and and CC cord-302316-raf5rlkq 211 21 arbidol arbidol NNP cord-302316-raf5rlkq 211 22 group group NN cord-302316-raf5rlkq 211 23 , , , cord-302316-raf5rlkq 211 24 respectively respectively RB cord-302316-raf5rlkq 211 25 , , , cord-302316-raf5rlkq 211 26 mainly mainly RB cord-302316-raf5rlkq 211 27 manifested manifest VBN cord-302316-raf5rlkq 211 28 as as IN cord-302316-raf5rlkq 211 29 diarrhoea diarrhoea NN cord-302316-raf5rlkq 211 30 . . . cord-302316-raf5rlkq 212 1 Thirteen thirteen CD cord-302316-raf5rlkq 212 2 patients patient NNS cord-302316-raf5rlkq 212 3 progressed progress VBD cord-302316-raf5rlkq 212 4 to to IN cord-302316-raf5rlkq 212 5 severe severe JJ cord-302316-raf5rlkq 212 6 disease disease NN cord-302316-raf5rlkq 212 7 during during IN cord-302316-raf5rlkq 212 8 hospitalization hospitalization NN cord-302316-raf5rlkq 212 9 : : : cord-302316-raf5rlkq 212 10 namely namely RB cord-302316-raf5rlkq 212 11 8 8 CD cord-302316-raf5rlkq 212 12 , , , cord-302316-raf5rlkq 212 13 3 3 CD cord-302316-raf5rlkq 212 14 and and CC cord-302316-raf5rlkq 212 15 2 2 CD cord-302316-raf5rlkq 212 16 in in IN cord-302316-raf5rlkq 212 17 lopinavir lopinavir NNS cord-302316-raf5rlkq 212 18 , , , cord-302316-raf5rlkq 212 19 arbidol arbidol NN cord-302316-raf5rlkq 212 20 and and CC cord-302316-raf5rlkq 212 21 control control NN cord-302316-raf5rlkq 212 22 group group NN cord-302316-raf5rlkq 212 23 , , , cord-302316-raf5rlkq 212 24 respectively respectively RB cord-302316-raf5rlkq 212 25 . . . cord-302316-raf5rlkq 213 1 The the DT cord-302316-raf5rlkq 213 2 study study NN cord-302316-raf5rlkq 213 3 is be VBZ cord-302316-raf5rlkq 213 4 small small JJ cord-302316-raf5rlkq 213 5 and and CC cord-302316-raf5rlkq 213 6 was be VBD cord-302316-raf5rlkq 213 7 only only RB cord-302316-raf5rlkq 213 8 conducted conduct VBN cord-302316-raf5rlkq 213 9 at at IN cord-302316-raf5rlkq 213 10 a a DT cord-302316-raf5rlkq 213 11 single single JJ cord-302316-raf5rlkq 213 12 centre centre NN cord-302316-raf5rlkq 213 13 , , , cord-302316-raf5rlkq 213 14 but but CC cord-302316-raf5rlkq 213 15 it -PRON- PRP cord-302316-raf5rlkq 213 16 still still RB cord-302316-raf5rlkq 213 17 confirms confirm VBZ cord-302316-raf5rlkq 213 18 the the DT cord-302316-raf5rlkq 213 19 lack lack NN cord-302316-raf5rlkq 213 20 of of IN cord-302316-raf5rlkq 213 21 efficacy efficacy NN cord-302316-raf5rlkq 213 22 of of IN cord-302316-raf5rlkq 213 23 lopinavir lopinavir NNP cord-302316-raf5rlkq 213 24 / / SYM cord-302316-raf5rlkq 213 25 ritonavir ritonavir NNP cord-302316-raf5rlkq 213 26 treatment treatment NN cord-302316-raf5rlkq 213 27 in in IN cord-302316-raf5rlkq 213 28 severe severe JJ cord-302316-raf5rlkq 213 29 COVID-19 covid-19 JJ cord-302316-raf5rlkq 213 30 cases case NNS cord-302316-raf5rlkq 214 1 ( ( -LRB- cord-302316-raf5rlkq 214 2 Li Li NNP cord-302316-raf5rlkq 214 3 et et NNP cord-302316-raf5rlkq 214 4 al al NNP cord-302316-raf5rlkq 214 5 . . NNP cord-302316-raf5rlkq 214 6 , , , cord-302316-raf5rlkq 214 7 2020b 2020b CD cord-302316-raf5rlkq 214 8 ) ) -RRB- cord-302316-raf5rlkq 214 9 . . . cord-302316-raf5rlkq 215 1 In in IN cord-302316-raf5rlkq 215 2 a a DT cord-302316-raf5rlkq 215 3 retrospective retrospective JJ cord-302316-raf5rlkq 215 4 cohort cohort NN cord-302316-raf5rlkq 215 5 study study NN cord-302316-raf5rlkq 215 6 with with IN cord-302316-raf5rlkq 215 7 33 33 CD cord-302316-raf5rlkq 215 8 Chinese chinese JJ cord-302316-raf5rlkq 215 9 patients patient NNS cord-302316-raf5rlkq 215 10 suffering suffer VBG cord-302316-raf5rlkq 215 11 from from IN cord-302316-raf5rlkq 215 12 moderate moderate JJ cord-302316-raf5rlkq 215 13 COVID-19 covid-19 JJ cord-302316-raf5rlkq 215 14 showing show VBG cord-302316-raf5rlkq 215 15 lung lung NN cord-302316-raf5rlkq 215 16 CT CT NNP cord-302316-raf5rlkq 215 17 abnormalities abnormality NNS cord-302316-raf5rlkq 215 18 , , , cord-302316-raf5rlkq 215 19 16 16 CD cord-302316-raf5rlkq 215 20 patients patient NNS cord-302316-raf5rlkq 215 21 were be VBD cord-302316-raf5rlkq 215 22 treated treat VBN cord-302316-raf5rlkq 215 23 with with IN cord-302316-raf5rlkq 215 24 an an DT cord-302316-raf5rlkq 215 25 arbidol arbidol NN cord-302316-raf5rlkq 215 26 / / SYM cord-302316-raf5rlkq 215 27 lopinavir lopinavir NNS cord-302316-raf5rlkq 215 28 / / SYM cord-302316-raf5rlkq 215 29 ritonavir ritonavir NNP cord-302316-raf5rlkq 215 30 combination combination NN cord-302316-raf5rlkq 215 31 while while IN cord-302316-raf5rlkq 215 32 17 17 CD cord-302316-raf5rlkq 215 33 patients patient NNS cord-302316-raf5rlkq 215 34 received receive VBD cord-302316-raf5rlkq 215 35 only only JJ cord-302316-raf5rlkq 215 36 lopinavir lopinavir NNS cord-302316-raf5rlkq 215 37 / / SYM cord-302316-raf5rlkq 215 38 ritonavir ritonavir NNS cord-302316-raf5rlkq 215 39 . . . cord-302316-raf5rlkq 216 1 The the DT cord-302316-raf5rlkq 216 2 group group NN cord-302316-raf5rlkq 216 3 including include VBG cord-302316-raf5rlkq 216 4 arbidol arbidol NN cord-302316-raf5rlkq 216 5 in in IN cord-302316-raf5rlkq 216 6 the the DT cord-302316-raf5rlkq 216 7 combination combination NN cord-302316-raf5rlkq 216 8 showed show VBD cord-302316-raf5rlkq 216 9 a a DT cord-302316-raf5rlkq 216 10 significantly significantly RB cord-302316-raf5rlkq 216 11 shorter short JJR cord-302316-raf5rlkq 216 12 nasopharyngeal nasopharyngeal JJ cord-302316-raf5rlkq 216 13 and and CC cord-302316-raf5rlkq 216 14 stool stool VB cord-302316-raf5rlkq 216 15 excretion excretion NN cord-302316-raf5rlkq 216 16 of of IN cord-302316-raf5rlkq 216 17 SARS SARS NNP cord-302316-raf5rlkq 216 18 - - HYPH cord-302316-raf5rlkq 216 19 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 216 20 , , , cord-302316-raf5rlkq 216 21 and and CC cord-302316-raf5rlkq 216 22 an an DT cord-302316-raf5rlkq 216 23 accelerated accelerated JJ cord-302316-raf5rlkq 216 24 normalization normalization NN cord-302316-raf5rlkq 216 25 of of IN cord-302316-raf5rlkq 216 26 lung lung NN cord-302316-raf5rlkq 216 27 CT CT NNP cord-302316-raf5rlkq 216 28 , , , cord-302316-raf5rlkq 216 29 compared compare VBN cord-302316-raf5rlkq 216 30 with with IN cord-302316-raf5rlkq 216 31 the the DT cord-302316-raf5rlkq 216 32 control control NN cord-302316-raf5rlkq 216 33 group group NN cord-302316-raf5rlkq 216 34 . . . cord-302316-raf5rlkq 217 1 The the DT cord-302316-raf5rlkq 217 2 positive positive JJ cord-302316-raf5rlkq 217 3 outcome outcome NN cord-302316-raf5rlkq 217 4 must must MD cord-302316-raf5rlkq 217 5 , , , cord-302316-raf5rlkq 217 6 however however RB cord-302316-raf5rlkq 217 7 , , , cord-302316-raf5rlkq 217 8 be be VB cord-302316-raf5rlkq 217 9 interpreted interpret VBN cord-302316-raf5rlkq 217 10 with with IN cord-302316-raf5rlkq 217 11 caution caution NN cord-302316-raf5rlkq 217 12 since since IN cord-302316-raf5rlkq 217 13 the the DT cord-302316-raf5rlkq 217 14 two two CD cord-302316-raf5rlkq 217 15 groups group NNS cord-302316-raf5rlkq 217 16 differed differ VBD cord-302316-raf5rlkq 217 17 significantly significantly RB cord-302316-raf5rlkq 217 18 for for IN cord-302316-raf5rlkq 217 19 glucocorticoid glucocorticoid NN cord-302316-raf5rlkq 217 20 treatment treatment NN cord-302316-raf5rlkq 217 21 ( ( -LRB- cord-302316-raf5rlkq 217 22 6 6 CD cord-302316-raf5rlkq 217 23 % % NN cord-302316-raf5rlkq 217 24 vs. vs. NN cord-302316-raf5rlkq 217 25 41 41 CD cord-302316-raf5rlkq 217 26 % % NN cord-302316-raf5rlkq 217 27 in in IN cord-302316-raf5rlkq 217 28 control control NN cord-302316-raf5rlkq 217 29 ) ) -RRB- cord-302316-raf5rlkq 217 30 . . . cord-302316-raf5rlkq 218 1 The the DT cord-302316-raf5rlkq 218 2 better well JJR cord-302316-raf5rlkq 218 3 outcome outcome NN cord-302316-raf5rlkq 218 4 in in IN cord-302316-raf5rlkq 218 5 the the DT cord-302316-raf5rlkq 218 6 arbidol arbidol NN cord-302316-raf5rlkq 218 7 arm arm NN cord-302316-raf5rlkq 218 8 could could MD cord-302316-raf5rlkq 218 9 therefore therefore RB cord-302316-raf5rlkq 218 10 be be VB cord-302316-raf5rlkq 218 11 due due JJ cord-302316-raf5rlkq 218 12 to to IN cord-302316-raf5rlkq 218 13 less less JJR cord-302316-raf5rlkq 218 14 use use NN cord-302316-raf5rlkq 218 15 of of IN cord-302316-raf5rlkq 218 16 detrimental detrimental JJ cord-302316-raf5rlkq 218 17 glucocorticoid glucocorticoid NN cord-302316-raf5rlkq 218 18 . . . cord-302316-raf5rlkq 219 1 Triple triple JJ cord-302316-raf5rlkq 219 2 therapy therapy NN cord-302316-raf5rlkq 219 3 : : : cord-302316-raf5rlkq 219 4 lopinavir lopinavir NNP cord-302316-raf5rlkq 219 5 , , . cord-302316-raf5rlkq 220 1 ribavirin ribavirin RB cord-302316-raf5rlkq 220 2 , , , cord-302316-raf5rlkq 220 3 interferon interferon NN cord-302316-raf5rlkq 221 1 beta-1b beta-1b NNS cord-302316-raf5rlkq 222 1 In in IN cord-302316-raf5rlkq 222 2 a a DT cord-302316-raf5rlkq 222 3 multicentre multicentre NNP cord-302316-raf5rlkq 222 4 trial trial NN cord-302316-raf5rlkq 222 5 , , , cord-302316-raf5rlkq 222 6 127 127 CD cord-302316-raf5rlkq 222 7 COVID-19 covid-19 CD cord-302316-raf5rlkq 222 8 patients patient NNS cord-302316-raf5rlkq 222 9 from from IN cord-302316-raf5rlkq 222 10 Hong Hong NNP cord-302316-raf5rlkq 222 11 Kong Kong NNP cord-302316-raf5rlkq 222 12 were be VBD cord-302316-raf5rlkq 222 13 enrolled enrol VBN cord-302316-raf5rlkq 222 14 into into IN cord-302316-raf5rlkq 222 15 a a DT cord-302316-raf5rlkq 222 16 prospective prospective NN cord-302316-raf5rlkq 222 17 , , , cord-302316-raf5rlkq 222 18 randomized randomized JJ cord-302316-raf5rlkq 222 19 , , , cord-302316-raf5rlkq 222 20 open open JJ cord-302316-raf5rlkq 222 21 - - HYPH cord-302316-raf5rlkq 222 22 label label NN cord-302316-raf5rlkq 222 23 phase phase NN cord-302316-raf5rlkq 222 24 2 2 CD cord-302316-raf5rlkq 222 25 clinical clinical JJ cord-302316-raf5rlkq 222 26 trial trial NN cord-302316-raf5rlkq 222 27 . . . cord-302316-raf5rlkq 223 1 Eighty eighty CD cord-302316-raf5rlkq 223 2 - - HYPH cord-302316-raf5rlkq 223 3 six six CD cord-302316-raf5rlkq 223 4 patients patient NNS cord-302316-raf5rlkq 223 5 received receive VBD cord-302316-raf5rlkq 223 6 a a DT cord-302316-raf5rlkq 223 7 combination combination NN cord-302316-raf5rlkq 223 8 treatment treatment NN cord-302316-raf5rlkq 223 9 of of IN cord-302316-raf5rlkq 223 10 the the DT cord-302316-raf5rlkq 223 11 lopinavir lopinavir NNS cord-302316-raf5rlkq 223 12 ( ( -LRB- cord-302316-raf5rlkq 223 13 plus plus CC cord-302316-raf5rlkq 223 14 ritonavir ritonavir NNP cord-302316-raf5rlkq 223 15 ) ) -RRB- cord-302316-raf5rlkq 223 16 , , , cord-302316-raf5rlkq 223 17 the the DT cord-302316-raf5rlkq 223 18 nucleoside nucleoside NN cord-302316-raf5rlkq 223 19 analog analog NN cord-302316-raf5rlkq 223 20 ribavirin ribavirin NN cord-302316-raf5rlkq 223 21 and and CC cord-302316-raf5rlkq 223 22 interferon interferon NN cord-302316-raf5rlkq 223 23 beta-1b beta-1b NNS cord-302316-raf5rlkq 223 24 , , , cord-302316-raf5rlkq 223 25 while while IN cord-302316-raf5rlkq 223 26 the the DT cord-302316-raf5rlkq 223 27 control control NN cord-302316-raf5rlkq 223 28 group group NN cord-302316-raf5rlkq 223 29 was be VBD cord-302316-raf5rlkq 223 30 only only RB cord-302316-raf5rlkq 223 31 treated treat VBN cord-302316-raf5rlkq 223 32 with with IN cord-302316-raf5rlkq 223 33 lopinavir lopinavir NNS cord-302316-raf5rlkq 223 34 ( ( -LRB- cord-302316-raf5rlkq 223 35 plus plus CC cord-302316-raf5rlkq 223 36 ritonavir ritonavir NNP cord-302316-raf5rlkq 223 37 ) ) -RRB- cord-302316-raf5rlkq 223 38 . . . cord-302316-raf5rlkq 224 1 At at IN cord-302316-raf5rlkq 224 2 baseline baseline NN cord-302316-raf5rlkq 224 3 , , , cord-302316-raf5rlkq 224 4 both both DT cord-302316-raf5rlkq 224 5 groups group NNS cord-302316-raf5rlkq 224 6 were be VBD cord-302316-raf5rlkq 224 7 well well RB cord-302316-raf5rlkq 224 8 matched match VBN cord-302316-raf5rlkq 224 9 and and CC cord-302316-raf5rlkq 224 10 showed show VBD cord-302316-raf5rlkq 224 11 mild mild JJ cord-302316-raf5rlkq 224 12 - - HYPH cord-302316-raf5rlkq 224 13 to to IN cord-302316-raf5rlkq 224 14 - - HYPH cord-302316-raf5rlkq 224 15 moderate moderate JJ cord-302316-raf5rlkq 224 16 disease disease NN cord-302316-raf5rlkq 224 17 . . . cord-302316-raf5rlkq 225 1 The the DT cord-302316-raf5rlkq 225 2 combination combination NN cord-302316-raf5rlkq 225 3 group group NN cord-302316-raf5rlkq 225 4 demonstrated demonstrate VBD cord-302316-raf5rlkq 225 5 , , , cord-302316-raf5rlkq 225 6 in in IN cord-302316-raf5rlkq 225 7 comparison comparison NN cord-302316-raf5rlkq 225 8 with with IN cord-302316-raf5rlkq 225 9 the the DT cord-302316-raf5rlkq 225 10 controls control NNS cord-302316-raf5rlkq 225 11 , , , cord-302316-raf5rlkq 225 12 a a DT cord-302316-raf5rlkq 225 13 significantly significantly RB cord-302316-raf5rlkq 225 14 reduced reduce VBN cord-302316-raf5rlkq 225 15 time time NN cord-302316-raf5rlkq 225 16 ( ( -LRB- cord-302316-raf5rlkq 225 17 7 7 CD cord-302316-raf5rlkq 225 18 vs. vs. NN cord-302316-raf5rlkq 225 19 12 12 CD cord-302316-raf5rlkq 225 20 days day NNS cord-302316-raf5rlkq 225 21 ) ) -RRB- cord-302316-raf5rlkq 225 22 to to IN cord-302316-raf5rlkq 225 23 clearance clearance NN cord-302316-raf5rlkq 225 24 of of IN cord-302316-raf5rlkq 225 25 viral viral JJ cord-302316-raf5rlkq 225 26 RNA RNA NNP cord-302316-raf5rlkq 225 27 in in IN cord-302316-raf5rlkq 225 28 the the DT cord-302316-raf5rlkq 225 29 nasopharynx nasopharynx NN cord-302316-raf5rlkq 225 30 ( ( -LRB- cord-302316-raf5rlkq 225 31 the the DT cord-302316-raf5rlkq 225 32 primary primary JJ cord-302316-raf5rlkq 225 33 end end NN cord-302316-raf5rlkq 225 34 - - HYPH cord-302316-raf5rlkq 225 35 point point NN cord-302316-raf5rlkq 225 36 ) ) -RRB- cord-302316-raf5rlkq 225 37 , , , cord-302316-raf5rlkq 225 38 as as RB cord-302316-raf5rlkq 225 39 well well RB cord-302316-raf5rlkq 225 40 as as IN cord-302316-raf5rlkq 225 41 a a DT cord-302316-raf5rlkq 225 42 shortening shortening NN cord-302316-raf5rlkq 225 43 of of IN cord-302316-raf5rlkq 225 44 oropharynx oropharynx NN cord-302316-raf5rlkq 225 45 , , , cord-302316-raf5rlkq 225 46 throat throat NN cord-302316-raf5rlkq 225 47 and and CC cord-302316-raf5rlkq 225 48 stool stool NN cord-302316-raf5rlkq 225 49 virus virus NN cord-302316-raf5rlkq 225 50 excretion excretion NN cord-302316-raf5rlkq 225 51 . . . cord-302316-raf5rlkq 226 1 The the DT cord-302316-raf5rlkq 226 2 combination combination NN cord-302316-raf5rlkq 226 3 therapy therapy NN cord-302316-raf5rlkq 226 4 was be VBD cord-302316-raf5rlkq 226 5 also also RB cord-302316-raf5rlkq 226 6 associated associate VBN cord-302316-raf5rlkq 226 7 with with IN cord-302316-raf5rlkq 226 8 significant significant JJ cord-302316-raf5rlkq 226 9 clinical clinical JJ cord-302316-raf5rlkq 226 10 improvement improvement NN cord-302316-raf5rlkq 226 11 compared compare VBN cord-302316-raf5rlkq 226 12 with with IN cord-302316-raf5rlkq 226 13 controls control NNS cord-302316-raf5rlkq 226 14 , , , cord-302316-raf5rlkq 226 15 and and CC cord-302316-raf5rlkq 226 16 a a DT cord-302316-raf5rlkq 226 17 shorter short JJR cord-302316-raf5rlkq 226 18 hospitalization hospitalization NN cord-302316-raf5rlkq 226 19 stay stay VB cord-302316-raf5rlkq 226 20 . . . cord-302316-raf5rlkq 227 1 There there EX cord-302316-raf5rlkq 227 2 were be VBD cord-302316-raf5rlkq 227 3 no no DT cord-302316-raf5rlkq 227 4 fatalities fatality NNS cord-302316-raf5rlkq 227 5 . . . cord-302316-raf5rlkq 228 1 The the DT cord-302316-raf5rlkq 228 2 treatment treatment NN cord-302316-raf5rlkq 228 3 group group NN cord-302316-raf5rlkq 228 4 also also RB cord-302316-raf5rlkq 228 5 displayed display VBD cord-302316-raf5rlkq 228 6 lower low JJR cord-302316-raf5rlkq 228 7 IL-6 IL-6 NNP cord-302316-raf5rlkq 228 8 values value NNS cord-302316-raf5rlkq 228 9 than than IN cord-302316-raf5rlkq 228 10 the the DT cord-302316-raf5rlkq 228 11 controls control NNS cord-302316-raf5rlkq 228 12 . . . cord-302316-raf5rlkq 229 1 A a DT cord-302316-raf5rlkq 229 2 post post FW cord-302316-raf5rlkq 229 3 hoc hoc FW cord-302316-raf5rlkq 229 4 subgroup subgroup NN cord-302316-raf5rlkq 229 5 analysis analysis NN cord-302316-raf5rlkq 229 6 comparing compare VBG cord-302316-raf5rlkq 229 7 76 76 CD cord-302316-raf5rlkq 229 8 patients patient NNS cord-302316-raf5rlkq 229 9 ( ( -LRB- cord-302316-raf5rlkq 229 10 52 52 CD cord-302316-raf5rlkq 229 11 in in IN cord-302316-raf5rlkq 229 12 combination combination NN cord-302316-raf5rlkq 229 13 and and CC cord-302316-raf5rlkq 229 14 24 24 CD cord-302316-raf5rlkq 229 15 in in IN cord-302316-raf5rlkq 229 16 control control NN cord-302316-raf5rlkq 229 17 group group NN cord-302316-raf5rlkq 229 18 ) ) -RRB- cord-302316-raf5rlkq 229 19 , , , cord-302316-raf5rlkq 229 20 who who WP cord-302316-raf5rlkq 229 21 started start VBD cord-302316-raf5rlkq 229 22 treatment treatment NN cord-302316-raf5rlkq 229 23 less less JJR cord-302316-raf5rlkq 229 24 than than IN cord-302316-raf5rlkq 229 25 7 7 CD cord-302316-raf5rlkq 229 26 days day NNS cord-302316-raf5rlkq 229 27 after after IN cord-302316-raf5rlkq 229 28 symptom symptom NN cord-302316-raf5rlkq 229 29 onset onset NN cord-302316-raf5rlkq 229 30 , , , cord-302316-raf5rlkq 229 31 showed show VBD cord-302316-raf5rlkq 229 32 again again RB cord-302316-raf5rlkq 229 33 a a DT cord-302316-raf5rlkq 229 34 significant significant JJ cord-302316-raf5rlkq 229 35 difference difference NN cord-302316-raf5rlkq 229 36 between between IN cord-302316-raf5rlkq 229 37 the the DT cord-302316-raf5rlkq 229 38 two two CD cord-302316-raf5rlkq 229 39 groups group NNS cord-302316-raf5rlkq 229 40 . . . cord-302316-raf5rlkq 230 1 In in IN cord-302316-raf5rlkq 230 2 contrast contrast NN cord-302316-raf5rlkq 230 3 , , , cord-302316-raf5rlkq 230 4 no no DT cord-302316-raf5rlkq 230 5 difference difference NN cord-302316-raf5rlkq 230 6 was be VBD cord-302316-raf5rlkq 230 7 seen see VBN cord-302316-raf5rlkq 230 8 between between IN cord-302316-raf5rlkq 230 9 the the DT cord-302316-raf5rlkq 230 10 two two CD cord-302316-raf5rlkq 230 11 groups group NNS cord-302316-raf5rlkq 230 12 when when WRB cord-302316-raf5rlkq 230 13 the the DT cord-302316-raf5rlkq 230 14 treatment treatment NN cord-302316-raf5rlkq 230 15 was be VBD cord-302316-raf5rlkq 230 16 initiated initiate VBN cord-302316-raf5rlkq 230 17 after after IN cord-302316-raf5rlkq 230 18 7 7 CD cord-302316-raf5rlkq 230 19 days day NNS cord-302316-raf5rlkq 230 20 . . . cord-302316-raf5rlkq 231 1 Out out IN cord-302316-raf5rlkq 231 2 of of IN cord-302316-raf5rlkq 231 3 concern concern NN cord-302316-raf5rlkq 231 4 for for IN cord-302316-raf5rlkq 231 5 safety safety NN cord-302316-raf5rlkq 231 6 , , , cord-302316-raf5rlkq 231 7 patients patient NNS cord-302316-raf5rlkq 231 8 in in IN cord-302316-raf5rlkq 231 9 the the DT cord-302316-raf5rlkq 231 10 combination combination NN cord-302316-raf5rlkq 231 11 group group NN cord-302316-raf5rlkq 231 12 did do VBD cord-302316-raf5rlkq 231 13 not not RB cord-302316-raf5rlkq 231 14 receive receive VB cord-302316-raf5rlkq 231 15 interferon interferon NN cord-302316-raf5rlkq 231 16 at at IN cord-302316-raf5rlkq 231 17 later later JJ cord-302316-raf5rlkq 231 18 stages stage NNS cord-302316-raf5rlkq 231 19 of of IN cord-302316-raf5rlkq 231 20 the the DT cord-302316-raf5rlkq 231 21 infection infection NN cord-302316-raf5rlkq 231 22 . . . cord-302316-raf5rlkq 232 1 The the DT cord-302316-raf5rlkq 232 2 therapeutic therapeutic JJ cord-302316-raf5rlkq 232 3 effect effect NN cord-302316-raf5rlkq 232 4 in in IN cord-302316-raf5rlkq 232 5 the the DT cord-302316-raf5rlkq 232 6 combination combination NN cord-302316-raf5rlkq 232 7 group group NN cord-302316-raf5rlkq 232 8 could could MD cord-302316-raf5rlkq 232 9 be be VB cord-302316-raf5rlkq 232 10 attributed attribute VBN cord-302316-raf5rlkq 232 11 to to IN cord-302316-raf5rlkq 232 12 either either CC cord-302316-raf5rlkq 232 13 earlier early JJR cord-302316-raf5rlkq 232 14 ribavirin ribavirin JJ cord-302316-raf5rlkq 232 15 treatment treatment NN cord-302316-raf5rlkq 232 16 or or CC cord-302316-raf5rlkq 232 17 interferon interferon NN cord-302316-raf5rlkq 232 18 inclusion inclusion NN cord-302316-raf5rlkq 233 1 ( ( -LRB- cord-302316-raf5rlkq 233 2 Hung Hung NNP cord-302316-raf5rlkq 233 3 et et FW cord-302316-raf5rlkq 233 4 al al NNP cord-302316-raf5rlkq 233 5 . . NNP cord-302316-raf5rlkq 233 6 , , , cord-302316-raf5rlkq 233 7 2020 2020 CD cord-302316-raf5rlkq 233 8 ) ) -RRB- cord-302316-raf5rlkq 233 9 . . . cord-302316-raf5rlkq 234 1 Anakinra Anakinra NNP cord-302316-raf5rlkq 234 2 is be VBZ cord-302316-raf5rlkq 234 3 a a DT cord-302316-raf5rlkq 234 4 recombinant recombinant JJ cord-302316-raf5rlkq 234 5 interleukin interleukin NN cord-302316-raf5rlkq 234 6 IL-1 IL-1 NNP cord-302316-raf5rlkq 234 7 receptor receptor NN cord-302316-raf5rlkq 234 8 antagonist antagonist NN cord-302316-raf5rlkq 234 9 . . . cord-302316-raf5rlkq 235 1 High high JJ cord-302316-raf5rlkq 235 2 - - HYPH cord-302316-raf5rlkq 235 3 dose dose NN cord-302316-raf5rlkq 235 4 intravenous intravenous JJ cord-302316-raf5rlkq 235 5 anakinra anakinra NN cord-302316-raf5rlkq 235 6 has have VBZ cord-302316-raf5rlkq 235 7 FDA FDA NNP cord-302316-raf5rlkq 235 8 and and CC cord-302316-raf5rlkq 235 9 EMA EMA NNP cord-302316-raf5rlkq 235 10 off off IN cord-302316-raf5rlkq 235 11 - - HYPH cord-302316-raf5rlkq 235 12 label label NN cord-302316-raf5rlkq 235 13 approval approval NN cord-302316-raf5rlkq 235 14 for for IN cord-302316-raf5rlkq 235 15 the the DT cord-302316-raf5rlkq 235 16 treatment treatment NN cord-302316-raf5rlkq 235 17 of of IN cord-302316-raf5rlkq 235 18 hyperinflammatory hyperinflammatory JJ cord-302316-raf5rlkq 235 19 conditions condition NNS cord-302316-raf5rlkq 235 20 such such JJ cord-302316-raf5rlkq 235 21 as as IN cord-302316-raf5rlkq 235 22 macrophage macrophage NN cord-302316-raf5rlkq 235 23 activation activation NN cord-302316-raf5rlkq 235 24 syndrome syndrome NN cord-302316-raf5rlkq 235 25 ( ( -LRB- cord-302316-raf5rlkq 235 26 see see VB cord-302316-raf5rlkq 235 27 above above IN cord-302316-raf5rlkq 235 28 coagulopathy coagulopathy NN cord-302316-raf5rlkq 235 29 ) ) -RRB- cord-302316-raf5rlkq 235 30 . . . cord-302316-raf5rlkq 236 1 A a DT cord-302316-raf5rlkq 236 2 Chinese chinese JJ cord-302316-raf5rlkq 236 3 study study NN cord-302316-raf5rlkq 236 4 used use VBD cord-302316-raf5rlkq 236 5 anakinra anakinra NNP cord-302316-raf5rlkq 236 6 in in IN cord-302316-raf5rlkq 236 7 severe severe JJ cord-302316-raf5rlkq 236 8 COVID-19 covid-19 JJ cord-302316-raf5rlkq 236 9 patients patient NNS cord-302316-raf5rlkq 236 10 who who WP cord-302316-raf5rlkq 236 11 could could MD cord-302316-raf5rlkq 236 12 not not RB cord-302316-raf5rlkq 236 13 receive receive VB cord-302316-raf5rlkq 236 14 intensive intensive JJ cord-302316-raf5rlkq 236 15 care care NN cord-302316-raf5rlkq 236 16 due due IN cord-302316-raf5rlkq 236 17 to to IN cord-302316-raf5rlkq 236 18 overwhelming overwhelming JJ cord-302316-raf5rlkq 236 19 patient patient JJ cord-302316-raf5rlkq 236 20 numbers number NNS cord-302316-raf5rlkq 236 21 . . . cord-302316-raf5rlkq 237 1 Low low JJ cord-302316-raf5rlkq 237 2 - - HYPH cord-302316-raf5rlkq 237 3 dose dose NN cord-302316-raf5rlkq 237 4 subcutaneous subcutaneous JJ cord-302316-raf5rlkq 237 5 anakinra anakinra NN cord-302316-raf5rlkq 237 6 ( ( -LRB- cord-302316-raf5rlkq 237 7 the the DT cord-302316-raf5rlkq 237 8 standard standard JJ cord-302316-raf5rlkq 237 9 application application NN cord-302316-raf5rlkq 237 10 ) ) -RRB- cord-302316-raf5rlkq 237 11 had have VBD cord-302316-raf5rlkq 237 12 no no DT cord-302316-raf5rlkq 237 13 effect effect NN cord-302316-raf5rlkq 237 14 on on IN cord-302316-raf5rlkq 237 15 C c NN cord-302316-raf5rlkq 237 16 - - HYPH cord-302316-raf5rlkq 237 17 reactive reactive JJ cord-302316-raf5rlkq 237 18 protein protein NN cord-302316-raf5rlkq 237 19 levels level NNS cord-302316-raf5rlkq 237 20 or or CC cord-302316-raf5rlkq 237 21 clinical clinical JJ cord-302316-raf5rlkq 237 22 parameters parameter NNS cord-302316-raf5rlkq 237 23 , , , cord-302316-raf5rlkq 237 24 compared compare VBN cord-302316-raf5rlkq 237 25 with with IN cord-302316-raf5rlkq 237 26 controls control NNS cord-302316-raf5rlkq 237 27 . . . cord-302316-raf5rlkq 238 1 High high JJ cord-302316-raf5rlkq 238 2 - - HYPH cord-302316-raf5rlkq 238 3 dose dose NN cord-302316-raf5rlkq 238 4 intravenous intravenous JJ cord-302316-raf5rlkq 238 5 anakinra anakinra NNP cord-302316-raf5rlkq 238 6 application application NN cord-302316-raf5rlkq 238 7 suppressed suppress VBD cord-302316-raf5rlkq 238 8 hyperinflammation hyperinflammation NN cord-302316-raf5rlkq 238 9 , , , cord-302316-raf5rlkq 238 10 as as IN cord-302316-raf5rlkq 238 11 documented document VBN cord-302316-raf5rlkq 238 12 by by IN cord-302316-raf5rlkq 238 13 a a DT cord-302316-raf5rlkq 238 14 decrease decrease NN cord-302316-raf5rlkq 238 15 in in IN cord-302316-raf5rlkq 238 16 Creactive Creactive NNP cord-302316-raf5rlkq 238 17 protein protein NN cord-302316-raf5rlkq 238 18 , , , cord-302316-raf5rlkq 238 19 and and CC cord-302316-raf5rlkq 238 20 resulted result VBD cord-302316-raf5rlkq 238 21 in in IN cord-302316-raf5rlkq 238 22 a a DT cord-302316-raf5rlkq 238 23 significantly significantly RB cord-302316-raf5rlkq 238 24 higher high JJR cord-302316-raf5rlkq 238 25 rate rate NN cord-302316-raf5rlkq 238 26 of of IN cord-302316-raf5rlkq 238 27 survival survival NN cord-302316-raf5rlkq 238 28 at at IN cord-302316-raf5rlkq 238 29 3 3 CD cord-302316-raf5rlkq 238 30 weeks week NNS cord-302316-raf5rlkq 238 31 compared compare VBN cord-302316-raf5rlkq 238 32 with with IN cord-302316-raf5rlkq 238 33 controls control NNS cord-302316-raf5rlkq 238 34 ( ( -LRB- cord-302316-raf5rlkq 238 35 90 90 CD cord-302316-raf5rlkq 238 36 vs. vs. NN cord-302316-raf5rlkq 238 37 56 56 CD cord-302316-raf5rlkq 238 38 % % NN cord-302316-raf5rlkq 238 39 ) ) -RRB- cord-302316-raf5rlkq 238 40 . . . cord-302316-raf5rlkq 239 1 The the DT cord-302316-raf5rlkq 239 2 retrospective retrospective JJ cord-302316-raf5rlkq 239 3 nature nature NN cord-302316-raf5rlkq 239 4 and and CC cord-302316-raf5rlkq 239 5 the the DT cord-302316-raf5rlkq 239 6 small small JJ cord-302316-raf5rlkq 239 7 number number NN cord-302316-raf5rlkq 239 8 of of IN cord-302316-raf5rlkq 239 9 patients patient NNS cord-302316-raf5rlkq 239 10 treated treat VBN cord-302316-raf5rlkq 239 11 limit limit VBP cord-302316-raf5rlkq 239 12 positive positive JJ cord-302316-raf5rlkq 239 13 conclusions conclusion NNS cord-302316-raf5rlkq 239 14 ( ( -LRB- cord-302316-raf5rlkq 239 15 Cavalli Cavalli NNP cord-302316-raf5rlkq 239 16 et et FW cord-302316-raf5rlkq 239 17 al al NNP cord-302316-raf5rlkq 239 18 . . NNP cord-302316-raf5rlkq 239 19 , , , cord-302316-raf5rlkq 239 20 2020 2020 CD cord-302316-raf5rlkq 239 21 ) ) -RRB- cord-302316-raf5rlkq 239 22 . . . cord-302316-raf5rlkq 240 1 According accord VBG cord-302316-raf5rlkq 240 2 to to IN cord-302316-raf5rlkq 240 3 a a DT cord-302316-raf5rlkq 240 4 popular popular JJ cord-302316-raf5rlkq 240 5 pathogenesis pathogenesis NN cord-302316-raf5rlkq 240 6 model model NN cord-302316-raf5rlkq 240 7 , , , cord-302316-raf5rlkq 240 8 interleukin interleukin VBN cord-302316-raf5rlkq 240 9 IL-6 IL-6 NNP cord-302316-raf5rlkq 240 10 production production NN cord-302316-raf5rlkq 240 11 induces induce VBZ cord-302316-raf5rlkq 240 12 immunopathology immunopathology NN cord-302316-raf5rlkq 240 13 in in IN cord-302316-raf5rlkq 240 14 severe severe JJ cord-302316-raf5rlkq 240 15 COVID-19 covid-19 JJ cord-302316-raf5rlkq 240 16 cases case NNS cord-302316-raf5rlkq 240 17 . . . cord-302316-raf5rlkq 241 1 Tocilizumab Tocilizumab NNP cord-302316-raf5rlkq 241 2 , , , cord-302316-raf5rlkq 241 3 a a DT cord-302316-raf5rlkq 241 4 recombinant recombinant JJ cord-302316-raf5rlkq 241 5 humanized humanize VBN cord-302316-raf5rlkq 241 6 monoclonal monoclonal JJ cord-302316-raf5rlkq 241 7 antibody antibody NN cord-302316-raf5rlkq 241 8 , , , cord-302316-raf5rlkq 241 9 which which WDT cord-302316-raf5rlkq 241 10 binds bind VBZ cord-302316-raf5rlkq 241 11 the the DT cord-302316-raf5rlkq 241 12 IL-6 IL-6 NNP cord-302316-raf5rlkq 241 13 receptor receptor NN cord-302316-raf5rlkq 241 14 and and CC cord-302316-raf5rlkq 241 15 inhibits inhibit VBZ cord-302316-raf5rlkq 241 16 its -PRON- PRP$ cord-302316-raf5rlkq 241 17 signal signal NN cord-302316-raf5rlkq 241 18 transduction transduction NN cord-302316-raf5rlkq 241 19 , , , cord-302316-raf5rlkq 241 20 has have VBZ cord-302316-raf5rlkq 241 21 been be VBN cord-302316-raf5rlkq 241 22 previously previously RB cord-302316-raf5rlkq 241 23 used use VBN cord-302316-raf5rlkq 241 24 in in IN cord-302316-raf5rlkq 241 25 the the DT cord-302316-raf5rlkq 241 26 treatment treatment NN cord-302316-raf5rlkq 241 27 of of IN cord-302316-raf5rlkq 241 28 a a DT cord-302316-raf5rlkq 241 29 special special JJ cord-302316-raf5rlkq 241 30 form form NN cord-302316-raf5rlkq 241 31 of of IN cord-302316-raf5rlkq 241 32 juvenile juvenile JJ cord-302316-raf5rlkq 241 33 arthritis arthritis NN cord-302316-raf5rlkq 241 34 associated associate VBN cord-302316-raf5rlkq 241 35 with with IN cord-302316-raf5rlkq 241 36 increased increase VBN cord-302316-raf5rlkq 241 37 IL-6 IL-6 NNP cord-302316-raf5rlkq 241 38 production production NN cord-302316-raf5rlkq 241 39 . . . cord-302316-raf5rlkq 242 1 This this DT cord-302316-raf5rlkq 242 2 monoclonal monoclonal JJ cord-302316-raf5rlkq 242 3 antibody antibody NN cord-302316-raf5rlkq 242 4 led lead VBD cord-302316-raf5rlkq 242 5 to to IN cord-302316-raf5rlkq 242 6 a a DT cord-302316-raf5rlkq 242 7 rapid rapid JJ cord-302316-raf5rlkq 242 8 increase increase NN cord-302316-raf5rlkq 242 9 in in IN cord-302316-raf5rlkq 242 10 blood blood NN cord-302316-raf5rlkq 242 11 lymphocytes lymphocyte NNS cord-302316-raf5rlkq 242 12 in in IN cord-302316-raf5rlkq 242 13 six six CD cord-302316-raf5rlkq 242 14 COVID-19 covid-19 CD cord-302316-raf5rlkq 242 15 patients patient NNS cord-302316-raf5rlkq 242 16 ( ( -LRB- cord-302316-raf5rlkq 242 17 Giamarellos Giamarellos NNP cord-302316-raf5rlkq 242 18 - - HYPH cord-302316-raf5rlkq 242 19 Bourboulis Bourboulis NNP cord-302316-raf5rlkq 242 20 et et NNP cord-302316-raf5rlkq 242 21 al al NNP cord-302316-raf5rlkq 242 22 . . NNP cord-302316-raf5rlkq 242 23 , , , cord-302316-raf5rlkq 242 24 2020 2020 CD cord-302316-raf5rlkq 242 25 ) ) -RRB- cord-302316-raf5rlkq 242 26 . . . cord-302316-raf5rlkq 243 1 Clinicians clinician NNS cord-302316-raf5rlkq 243 2 from from IN cord-302316-raf5rlkq 243 3 China China NNP cord-302316-raf5rlkq 243 4 gave give VBD cord-302316-raf5rlkq 243 5 tocilizumab tocilizumab NNS cord-302316-raf5rlkq 243 6 to to IN cord-302316-raf5rlkq 243 7 21 21 CD cord-302316-raf5rlkq 243 8 patients patient NNS cord-302316-raf5rlkq 243 9 with with IN cord-302316-raf5rlkq 243 10 severe severe JJ cord-302316-raf5rlkq 243 11 or or CC cord-302316-raf5rlkq 243 12 critical critical JJ cord-302316-raf5rlkq 243 13 COVID-19 covid-19 NN cord-302316-raf5rlkq 243 14 who who WP cord-302316-raf5rlkq 243 15 had have VBD cord-302316-raf5rlkq 243 16 failed fail VBN cord-302316-raf5rlkq 243 17 to to TO cord-302316-raf5rlkq 243 18 respond respond VB cord-302316-raf5rlkq 243 19 to to IN cord-302316-raf5rlkq 243 20 standard standard JJ cord-302316-raf5rlkq 243 21 therapy therapy NN cord-302316-raf5rlkq 243 22 . . . cord-302316-raf5rlkq 244 1 One one CD cord-302316-raf5rlkq 244 2 day day NN cord-302316-raf5rlkq 244 3 after after IN cord-302316-raf5rlkq 244 4 the the DT cord-302316-raf5rlkq 244 5 injection injection NN cord-302316-raf5rlkq 244 6 of of IN cord-302316-raf5rlkq 244 7 tocilizumab tocilizumab NNP cord-302316-raf5rlkq 244 8 , , , cord-302316-raf5rlkq 244 9 the the DT cord-302316-raf5rlkq 244 10 fever fever NN cord-302316-raf5rlkq 244 11 disappeared disappear VBD cord-302316-raf5rlkq 244 12 in in IN cord-302316-raf5rlkq 244 13 all all DT cord-302316-raf5rlkq 244 14 patients patient NNS cord-302316-raf5rlkq 244 15 , , , cord-302316-raf5rlkq 244 16 C c NN cord-302316-raf5rlkq 244 17 - - HYPH cord-302316-raf5rlkq 244 18 reactive reactive JJ cord-302316-raf5rlkq 244 19 protein protein NN cord-302316-raf5rlkq 244 20 returned return VBD cord-302316-raf5rlkq 244 21 to to IN cord-302316-raf5rlkq 244 22 normal normal JJ cord-302316-raf5rlkq 244 23 in in IN cord-302316-raf5rlkq 244 24 most most JJS cord-302316-raf5rlkq 244 25 of of IN cord-302316-raf5rlkq 244 26 them -PRON- PRP cord-302316-raf5rlkq 244 27 , , , cord-302316-raf5rlkq 244 28 peripheral peripheral JJ cord-302316-raf5rlkq 244 29 oxygen oxygen NN cord-302316-raf5rlkq 244 30 saturation saturation NN cord-302316-raf5rlkq 244 31 improved improve VBN cord-302316-raf5rlkq 244 32 , , , cord-302316-raf5rlkq 244 33 CT CT NNP cord-302316-raf5rlkq 244 34 - - HYPH cord-302316-raf5rlkq 244 35 documented document VBN cord-302316-raf5rlkq 244 36 lung lung NN cord-302316-raf5rlkq 244 37 damage damage NN cord-302316-raf5rlkq 244 38 ameliorated ameliorate VBN cord-302316-raf5rlkq 244 39 , , , cord-302316-raf5rlkq 244 40 and and CC cord-302316-raf5rlkq 244 41 the the DT cord-302316-raf5rlkq 244 42 virus virus NN cord-302316-raf5rlkq 244 43 was be VBD cord-302316-raf5rlkq 244 44 cleared clear VBN cord-302316-raf5rlkq 244 45 . . . cord-302316-raf5rlkq 245 1 Adverse adverse JJ cord-302316-raf5rlkq 245 2 effects effect NNS cord-302316-raf5rlkq 245 3 were be VBD cord-302316-raf5rlkq 245 4 not not RB cord-302316-raf5rlkq 245 5 observed observe VBN cord-302316-raf5rlkq 245 6 , , , cord-302316-raf5rlkq 245 7 and and CC cord-302316-raf5rlkq 245 8 all all DT cord-302316-raf5rlkq 245 9 patients patient NNS cord-302316-raf5rlkq 245 10 were be VBD cord-302316-raf5rlkq 245 11 discharged discharge VBN cord-302316-raf5rlkq 246 1 ( ( -LRB- cord-302316-raf5rlkq 246 2 Xua Xua NNP cord-302316-raf5rlkq 246 3 et et NNP cord-302316-raf5rlkq 246 4 al al NNP cord-302316-raf5rlkq 246 5 . . NNP cord-302316-raf5rlkq 246 6 , , , cord-302316-raf5rlkq 246 7 2020 2020 CD cord-302316-raf5rlkq 246 8 ) ) -RRB- cord-302316-raf5rlkq 246 9 . . . cord-302316-raf5rlkq 247 1 Three three CD cord-302316-raf5rlkq 247 2 weeks week NNS cord-302316-raf5rlkq 247 3 after after IN cord-302316-raf5rlkq 247 4 the the DT cord-302316-raf5rlkq 247 5 onset onset NN cord-302316-raf5rlkq 247 6 of of IN cord-302316-raf5rlkq 247 7 disease disease NN cord-302316-raf5rlkq 247 8 , , , cord-302316-raf5rlkq 247 9 6 6 CD cord-302316-raf5rlkq 247 10 severely severely RB cord-302316-raf5rlkq 247 11 ill ill JJ cord-302316-raf5rlkq 248 1 COVID-19 covid-19 JJ cord-302316-raf5rlkq 248 2 patients patient NNS cord-302316-raf5rlkq 248 3 received receive VBD cord-302316-raf5rlkq 248 4 plasma plasma NN cord-302316-raf5rlkq 248 5 from from IN cord-302316-raf5rlkq 248 6 convalescent convalescent JJ cord-302316-raf5rlkq 248 7 COVID-19 covid-19 CD cord-302316-raf5rlkq 248 8 patients patient NNS cord-302316-raf5rlkq 248 9 , , , cord-302316-raf5rlkq 248 10 while while IN cord-302316-raf5rlkq 248 11 11 11 CD cord-302316-raf5rlkq 248 12 COVID-19 covid-19 CD cord-302316-raf5rlkq 248 13 patients patient NNS cord-302316-raf5rlkq 248 14 received receive VBD cord-302316-raf5rlkq 248 15 non non JJ cord-302316-raf5rlkq 248 16 - - JJ cord-302316-raf5rlkq 248 17 convalescent convalescent JJ cord-302316-raf5rlkq 248 18 plasma plasma NN cord-302316-raf5rlkq 248 19 as as IN cord-302316-raf5rlkq 248 20 a a DT cord-302316-raf5rlkq 248 21 control control NN cord-302316-raf5rlkq 248 22 . . . cord-302316-raf5rlkq 249 1 Convalescent convalescent JJ cord-302316-raf5rlkq 249 2 plasma plasma NN cord-302316-raf5rlkq 249 3 application application NN cord-302316-raf5rlkq 249 4 was be VBD cord-302316-raf5rlkq 249 5 linked link VBN cord-302316-raf5rlkq 249 6 to to IN cord-302316-raf5rlkq 249 7 a a DT cord-302316-raf5rlkq 249 8 significantly significantly RB cord-302316-raf5rlkq 249 9 higher high JJR cord-302316-raf5rlkq 249 10 viral viral JJ cord-302316-raf5rlkq 249 11 clearance clearance NN cord-302316-raf5rlkq 249 12 over over IN cord-302316-raf5rlkq 249 13 controls control NNS cord-302316-raf5rlkq 249 14 ( ( -LRB- cord-302316-raf5rlkq 249 15 100 100 CD cord-302316-raf5rlkq 249 16 vs vs IN cord-302316-raf5rlkq 249 17 21 21 CD cord-302316-raf5rlkq 249 18 % % NN cord-302316-raf5rlkq 249 19 ) ) -RRB- cord-302316-raf5rlkq 249 20 but but CC cord-302316-raf5rlkq 249 21 did do VBD cord-302316-raf5rlkq 249 22 not not RB cord-302316-raf5rlkq 249 23 affect affect VB cord-302316-raf5rlkq 249 24 mortality mortality NN cord-302316-raf5rlkq 249 25 which which WDT cord-302316-raf5rlkq 249 26 was be VBD cord-302316-raf5rlkq 249 27 high high JJ cord-302316-raf5rlkq 249 28 in in IN cord-302316-raf5rlkq 249 29 both both DT cord-302316-raf5rlkq 249 30 groups group NNS cord-302316-raf5rlkq 249 31 ( ( -LRB- cord-302316-raf5rlkq 249 32 5/6 5/6 CD cord-302316-raf5rlkq 249 33 and and CC cord-302316-raf5rlkq 249 34 10/11 10/11 CD cord-302316-raf5rlkq 249 35 died die VBD cord-302316-raf5rlkq 249 36 ) ) -RRB- cord-302316-raf5rlkq 249 37 . . . cord-302316-raf5rlkq 250 1 In in IN cord-302316-raf5rlkq 250 2 a a DT cord-302316-raf5rlkq 250 3 retrospective retrospective JJ cord-302316-raf5rlkq 250 4 study study NN cord-302316-raf5rlkq 250 5 from from IN cord-302316-raf5rlkq 250 6 China China NNP cord-302316-raf5rlkq 250 7 , , , cord-302316-raf5rlkq 250 8 20 20 CD cord-302316-raf5rlkq 250 9 % % NN cord-302316-raf5rlkq 250 10 of of IN cord-302316-raf5rlkq 250 11 449 449 CD cord-302316-raf5rlkq 250 12 severely severely RB cord-302316-raf5rlkq 250 13 ill ill JJ cord-302316-raf5rlkq 250 14 COVID-19 covid-19 CD cord-302316-raf5rlkq 250 15 patients patient NNS cord-302316-raf5rlkq 250 16 were be VBD cord-302316-raf5rlkq 250 17 treated treat VBN cord-302316-raf5rlkq 250 18 with with IN cord-302316-raf5rlkq 250 19 the the DT cord-302316-raf5rlkq 250 20 coagulation coagulation NN cord-302316-raf5rlkq 250 21 inhibitor inhibitor NN cord-302316-raf5rlkq 250 22 heparin heparin NN cord-302316-raf5rlkq 250 23 . . . cord-302316-raf5rlkq 251 1 Mortality mortality NN cord-302316-raf5rlkq 251 2 was be VBD cord-302316-raf5rlkq 251 3 30 30 CD cord-302316-raf5rlkq 251 4 % % NN cord-302316-raf5rlkq 251 5 , , , cord-302316-raf5rlkq 251 6 irrespective irrespective RB cord-302316-raf5rlkq 251 7 of of IN cord-302316-raf5rlkq 251 8 whether whether IN cord-302316-raf5rlkq 251 9 heparin heparin NN cord-302316-raf5rlkq 251 10 was be VBD cord-302316-raf5rlkq 251 11 given give VBN cord-302316-raf5rlkq 251 12 or or CC cord-302316-raf5rlkq 251 13 not not RB cord-302316-raf5rlkq 251 14 . . . cord-302316-raf5rlkq 252 1 However however RB cord-302316-raf5rlkq 252 2 , , , cord-302316-raf5rlkq 252 3 when when WRB cord-302316-raf5rlkq 252 4 patients patient NNS cord-302316-raf5rlkq 252 5 were be VBD cord-302316-raf5rlkq 252 6 stratified stratify VBN cord-302316-raf5rlkq 252 7 with with IN cord-302316-raf5rlkq 252 8 respect respect NN cord-302316-raf5rlkq 252 9 to to IN cord-302316-raf5rlkq 252 10 coagulopathy coagulopathy NN cord-302316-raf5rlkq 252 11 at at IN cord-302316-raf5rlkq 252 12 baseline baseline NN cord-302316-raf5rlkq 252 13 ( ( -LRB- cord-302316-raf5rlkq 252 14 using use VBG cord-302316-raf5rlkq 252 15 D d NN cord-302316-raf5rlkq 252 16 - - HYPH cord-302316-raf5rlkq 252 17 dimer dimer NN cord-302316-raf5rlkq 252 18 concentration concentration NN cord-302316-raf5rlkq 252 19 sixfold sixfold VBP cord-302316-raf5rlkq 252 20 higher higher RBR cord-302316-raf5rlkq 252 21 than than IN cord-302316-raf5rlkq 252 22 normal normal JJ cord-302316-raf5rlkq 252 23 as as IN cord-302316-raf5rlkq 252 24 threshold threshold NN cord-302316-raf5rlkq 252 25 ) ) -RRB- cord-302316-raf5rlkq 252 26 , , , cord-302316-raf5rlkq 252 27 a a DT cord-302316-raf5rlkq 252 28 20 20 CD cord-302316-raf5rlkq 252 29 % % NN cord-302316-raf5rlkq 252 30 reduction reduction NN cord-302316-raf5rlkq 252 31 in in IN cord-302316-raf5rlkq 252 32 mortality mortality NN cord-302316-raf5rlkq 252 33 was be VBD cord-302316-raf5rlkq 252 34 associated associate VBN cord-302316-raf5rlkq 252 35 with with IN cord-302316-raf5rlkq 252 36 heparin heparin JJ cord-302316-raf5rlkq 252 37 use use NN cord-302316-raf5rlkq 252 38 . . . cord-302316-raf5rlkq 253 1 The the DT cord-302316-raf5rlkq 253 2 data datum NNS cord-302316-raf5rlkq 253 3 need need VBP cord-302316-raf5rlkq 253 4 to to TO cord-302316-raf5rlkq 253 5 be be VB cord-302316-raf5rlkq 253 6 interpreted interpret VBN cord-302316-raf5rlkq 253 7 with with IN cord-302316-raf5rlkq 253 8 caution caution NN cord-302316-raf5rlkq 253 9 , , , cord-302316-raf5rlkq 253 10 since since IN cord-302316-raf5rlkq 253 11 they -PRON- PRP cord-302316-raf5rlkq 253 12 come come VBP cord-302316-raf5rlkq 253 13 from from IN cord-302316-raf5rlkq 253 14 a a DT cord-302316-raf5rlkq 253 15 retrospective retrospective JJ cord-302316-raf5rlkq 253 16 subgroup subgroup NN cord-302316-raf5rlkq 253 17 analysis analysis NN cord-302316-raf5rlkq 253 18 . . . cord-302316-raf5rlkq 254 1 Hydroxycytidine Hydroxycytidine NNP cord-302316-raf5rlkq 254 2 A a DT cord-302316-raf5rlkq 254 3 promising promising JJ cord-302316-raf5rlkq 254 4 prodrug prodrug NN cord-302316-raf5rlkq 254 5 is be VBZ cord-302316-raf5rlkq 254 6 the the DT cord-302316-raf5rlkq 254 7 nucleotide nucleotide JJ cord-302316-raf5rlkq 254 8 analog analog NN cord-302316-raf5rlkq 254 9 hydroxycytidine hydroxycytidine NNP cord-302316-raf5rlkq 254 10 . . . cord-302316-raf5rlkq 255 1 In in IN cord-302316-raf5rlkq 255 2 cell cell NN cord-302316-raf5rlkq 255 3 culture culture NN cord-302316-raf5rlkq 255 4 infections infection NNS cord-302316-raf5rlkq 255 5 , , , cord-302316-raf5rlkq 255 6 this this DT cord-302316-raf5rlkq 255 7 drug drug NN cord-302316-raf5rlkq 255 8 is be VBZ cord-302316-raf5rlkq 255 9 active active JJ cord-302316-raf5rlkq 255 10 against against IN cord-302316-raf5rlkq 255 11 a a DT cord-302316-raf5rlkq 255 12 wide wide JJ cord-302316-raf5rlkq 255 13 range range NN cord-302316-raf5rlkq 255 14 of of IN cord-302316-raf5rlkq 255 15 human human NN cord-302316-raf5rlkq 255 16 and and CC cord-302316-raf5rlkq 255 17 bat bat NN cord-302316-raf5rlkq 255 18 coronaviruses coronaviruse NNS cord-302316-raf5rlkq 255 19 thus thus RB cord-302316-raf5rlkq 255 20 potentially potentially RB cord-302316-raf5rlkq 255 21 offering offer VBG cord-302316-raf5rlkq 255 22 inhibitory inhibitory JJ cord-302316-raf5rlkq 255 23 activity activity NN cord-302316-raf5rlkq 255 24 against against IN cord-302316-raf5rlkq 255 25 future future JJ cord-302316-raf5rlkq 255 26 spill spill NN cord-302316-raf5rlkq 255 27 - - HYPH cord-302316-raf5rlkq 255 28 over over RP cord-302316-raf5rlkq 255 29 infections infection NNS cord-302316-raf5rlkq 255 30 from from IN cord-302316-raf5rlkq 255 31 animals animal NNS cord-302316-raf5rlkq 255 32 ( ( -LRB- cord-302316-raf5rlkq 255 33 zoonosis zoonosis NN cord-302316-raf5rlkq 255 34 ) ) -RRB- cord-302316-raf5rlkq 255 35 . . . cord-302316-raf5rlkq 256 1 The the DT cord-302316-raf5rlkq 256 2 drug drug NN cord-302316-raf5rlkq 256 3 increases increase VBZ cord-302316-raf5rlkq 256 4 the the DT cord-302316-raf5rlkq 256 5 mutation mutation NN cord-302316-raf5rlkq 256 6 rate rate NN cord-302316-raf5rlkq 256 7 of of IN cord-302316-raf5rlkq 256 8 the the DT cord-302316-raf5rlkq 256 9 virus virus NN cord-302316-raf5rlkq 256 10 during during IN cord-302316-raf5rlkq 256 11 replication replication NN cord-302316-raf5rlkq 256 12 resulting result VBG cord-302316-raf5rlkq 256 13 in in IN cord-302316-raf5rlkq 256 14 infectivity infectivity NN cord-302316-raf5rlkq 256 15 losses loss NNS cord-302316-raf5rlkq 256 16 . . . cord-302316-raf5rlkq 257 1 In in IN cord-302316-raf5rlkq 257 2 mouse mouse NN cord-302316-raf5rlkq 257 3 infection infection NN cord-302316-raf5rlkq 257 4 models model NNS cord-302316-raf5rlkq 257 5 for for IN cord-302316-raf5rlkq 257 6 SARS SARS NNP cord-302316-raf5rlkq 257 7 - - HYPH cord-302316-raf5rlkq 257 8 CoV CoV NNP cord-302316-raf5rlkq 257 9 and and CC cord-302316-raf5rlkq 257 10 MERS MERS NNP cord-302316-raf5rlkq 257 11 virus virus NN cord-302316-raf5rlkq 257 12 , , , cord-302316-raf5rlkq 257 13 it -PRON- PRP cord-302316-raf5rlkq 257 14 had have VBD cord-302316-raf5rlkq 257 15 good good JJ cord-302316-raf5rlkq 257 16 oral oral JJ cord-302316-raf5rlkq 257 17 bioavailability bioavailability NN cord-302316-raf5rlkq 257 18 , , , cord-302316-raf5rlkq 257 19 ameliorated ameliorated JJ cord-302316-raf5rlkq 257 20 lung lung NN cord-302316-raf5rlkq 257 21 function function NN cord-302316-raf5rlkq 257 22 , , , cord-302316-raf5rlkq 257 23 reduced reduce VBN cord-302316-raf5rlkq 257 24 virus virus NN cord-302316-raf5rlkq 257 25 titre titre NN cord-302316-raf5rlkq 257 26 and and CC cord-302316-raf5rlkq 257 27 diminished diminish VBD cord-302316-raf5rlkq 257 28 weight weight NN cord-302316-raf5rlkq 257 29 loss loss NN cord-302316-raf5rlkq 257 30 caused cause VBN cord-302316-raf5rlkq 257 31 by by IN cord-302316-raf5rlkq 257 32 the the DT cord-302316-raf5rlkq 257 33 viral viral JJ cord-302316-raf5rlkq 257 34 infection infection NN cord-302316-raf5rlkq 257 35 . . . cord-302316-raf5rlkq 258 1 The the DT cord-302316-raf5rlkq 258 2 drug drug NN cord-302316-raf5rlkq 258 3 demonstrated demonstrate VBD cord-302316-raf5rlkq 258 4 therapeutic therapeutic JJ cord-302316-raf5rlkq 258 5 effects effect NNS cord-302316-raf5rlkq 258 6 up up IN cord-302316-raf5rlkq 258 7 to to TO cord-302316-raf5rlkq 258 8 24 24 CD cord-302316-raf5rlkq 258 9 h h NN cord-302316-raf5rlkq 258 10 after after IN cord-302316-raf5rlkq 258 11 infection infection NN cord-302316-raf5rlkq 258 12 , , , cord-302316-raf5rlkq 258 13 which which WDT cord-302316-raf5rlkq 258 14 is be VBZ cord-302316-raf5rlkq 258 15 substantial substantial JJ cord-302316-raf5rlkq 258 16 since since IN cord-302316-raf5rlkq 258 17 mice mouse NNS cord-302316-raf5rlkq 258 18 show show VBP cord-302316-raf5rlkq 258 19 a a DT cord-302316-raf5rlkq 258 20 compressed compress VBN cord-302316-raf5rlkq 258 21 disease disease NN cord-302316-raf5rlkq 258 22 course course NN cord-302316-raf5rlkq 258 23 compared compare VBN cord-302316-raf5rlkq 258 24 to to IN cord-302316-raf5rlkq 258 25 that that DT cord-302316-raf5rlkq 258 26 of of IN cord-302316-raf5rlkq 258 27 humans human NNS cord-302316-raf5rlkq 258 28 . . . cord-302316-raf5rlkq 259 1 Coronaviruses coronaviruse NNS cord-302316-raf5rlkq 259 2 that that WDT cord-302316-raf5rlkq 259 3 had have VBD cord-302316-raf5rlkq 259 4 become become VBN cord-302316-raf5rlkq 259 5 resistant resistant JJ cord-302316-raf5rlkq 259 6 to to IN cord-302316-raf5rlkq 259 7 remdesivir remdesivir NNP cord-302316-raf5rlkq 259 8 showed show VBD cord-302316-raf5rlkq 259 9 enhanced enhanced JJ cord-302316-raf5rlkq 259 10 susceptibility susceptibility NN cord-302316-raf5rlkq 259 11 to to IN cord-302316-raf5rlkq 259 12 inhibition inhibition NN cord-302316-raf5rlkq 259 13 by by IN cord-302316-raf5rlkq 259 14 hydroxycytidine hydroxycytidine NNP cord-302316-raf5rlkq 259 15 ( ( -LRB- cord-302316-raf5rlkq 259 16 Sheahan Sheahan NNP cord-302316-raf5rlkq 259 17 et et NNP cord-302316-raf5rlkq 259 18 al al NNP cord-302316-raf5rlkq 259 19 . . NNP cord-302316-raf5rlkq 259 20 , , , cord-302316-raf5rlkq 259 21 2020 2020 CD cord-302316-raf5rlkq 259 22 ) ) -RRB- cord-302316-raf5rlkq 259 23 . . . cord-302316-raf5rlkq 260 1 Hydroxycytidine Hydroxycytidine NNP cord-302316-raf5rlkq 260 2 causes cause VBZ cord-302316-raf5rlkq 260 3 mutagenesis mutagenesis NN cord-302316-raf5rlkq 260 4 in in IN cord-302316-raf5rlkq 260 5 the the DT cord-302316-raf5rlkq 260 6 bacterium bacterium NN cord-302316-raf5rlkq 260 7 Escherichia Escherichia NNP cord-302316-raf5rlkq 260 8 coli coli NNS cord-302316-raf5rlkq 260 9 and and CC cord-302316-raf5rlkq 260 10 the the DT cord-302316-raf5rlkq 260 11 fungus fungus NN cord-302316-raf5rlkq 260 12 Neurospora Neurospora NNP cord-302316-raf5rlkq 260 13 crassa crassa NN cord-302316-raf5rlkq 260 14 . . . cord-302316-raf5rlkq 261 1 Cell cell NN cord-302316-raf5rlkq 261 2 protease protease NN cord-302316-raf5rlkq 261 3 inhibitor inhibitor NN cord-302316-raf5rlkq 261 4 SARS SARS NNP cord-302316-raf5rlkq 261 5 - - HYPH cord-302316-raf5rlkq 261 6 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 261 7 needs need VBZ cord-302316-raf5rlkq 261 8 , , , cord-302316-raf5rlkq 261 9 after after IN cord-302316-raf5rlkq 261 10 the the DT cord-302316-raf5rlkq 261 11 docking docking NN cord-302316-raf5rlkq 261 12 of of IN cord-302316-raf5rlkq 261 13 its -PRON- PRP$ cord-302316-raf5rlkq 261 14 spike spike NN cord-302316-raf5rlkq 261 15 protein protein NN cord-302316-raf5rlkq 261 16 to to IN cord-302316-raf5rlkq 261 17 the the DT cord-302316-raf5rlkq 261 18 cell cell NN cord-302316-raf5rlkq 261 19 receptor receptor NN cord-302316-raf5rlkq 261 20 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 261 21 , , , cord-302316-raf5rlkq 261 22 a a DT cord-302316-raf5rlkq 261 23 proteolytic proteolytic JJ cord-302316-raf5rlkq 261 24 cleavage cleavage NN cord-302316-raf5rlkq 261 25 of of IN cord-302316-raf5rlkq 261 26 the the DT cord-302316-raf5rlkq 261 27 spike spike NN cord-302316-raf5rlkq 261 28 protein protein NN cord-302316-raf5rlkq 261 29 at at IN cord-302316-raf5rlkq 261 30 a a DT cord-302316-raf5rlkq 261 31 polybasic polybasic JJ cord-302316-raf5rlkq 261 32 site site NN cord-302316-raf5rlkq 261 33 separating separate VBG cord-302316-raf5rlkq 261 34 the the DT cord-302316-raf5rlkq 261 35 S S NNP cord-302316-raf5rlkq 261 36 protein protein NN cord-302316-raf5rlkq 261 37 into into IN cord-302316-raf5rlkq 261 38 two two CD cord-302316-raf5rlkq 261 39 protein protein NN cord-302316-raf5rlkq 261 40 fragments fragment NNS cord-302316-raf5rlkq 261 41 S1 s1 NN cord-302316-raf5rlkq 261 42 and and CC cord-302316-raf5rlkq 261 43 S2 S2 NNP cord-302316-raf5rlkq 261 44 , , , cord-302316-raf5rlkq 261 45 where where WRB cord-302316-raf5rlkq 261 46 S2 S2 NNP cord-302316-raf5rlkq 261 47 mediates mediate VBZ cord-302316-raf5rlkq 261 48 the the DT cord-302316-raf5rlkq 261 49 fusion fusion NN cord-302316-raf5rlkq 261 50 of of IN cord-302316-raf5rlkq 261 51 the the DT cord-302316-raf5rlkq 261 52 viral viral JJ cord-302316-raf5rlkq 261 53 and and CC cord-302316-raf5rlkq 261 54 cell cell NN cord-302316-raf5rlkq 261 55 membranes membrane NNS cord-302316-raf5rlkq 261 56 , , , cord-302316-raf5rlkq 261 57 which which WDT cord-302316-raf5rlkq 261 58 leads lead VBZ cord-302316-raf5rlkq 261 59 to to IN cord-302316-raf5rlkq 261 60 the the DT cord-302316-raf5rlkq 261 61 entry entry NN cord-302316-raf5rlkq 261 62 of of IN cord-302316-raf5rlkq 261 63 the the DT cord-302316-raf5rlkq 261 64 viral viral JJ cord-302316-raf5rlkq 261 65 genome genome NN cord-302316-raf5rlkq 261 66 into into IN cord-302316-raf5rlkq 261 67 the the DT cord-302316-raf5rlkq 261 68 infected infected JJ cord-302316-raf5rlkq 261 69 cell cell NN cord-302316-raf5rlkq 261 70 . . . cord-302316-raf5rlkq 262 1 Cell cell NN cord-302316-raf5rlkq 262 2 culture culture NN cord-302316-raf5rlkq 262 3 infection infection NN cord-302316-raf5rlkq 262 4 tests test NNS cord-302316-raf5rlkq 262 5 demonstrated demonstrate VBD cord-302316-raf5rlkq 262 6 that that IN cord-302316-raf5rlkq 262 7 SARS SARS NNP cord-302316-raf5rlkq 262 8 - - HYPH cord-302316-raf5rlkq 262 9 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 262 10 uses use VBZ cord-302316-raf5rlkq 262 11 two two CD cord-302316-raf5rlkq 262 12 proteases protease NNS cord-302316-raf5rlkq 262 13 for for IN cord-302316-raf5rlkq 262 14 this this DT cord-302316-raf5rlkq 262 15 proteolytic proteolytic JJ cord-302316-raf5rlkq 262 16 processing processing NN cord-302316-raf5rlkq 262 17 , , , cord-302316-raf5rlkq 262 18 either either CC cord-302316-raf5rlkq 262 19 the the DT cord-302316-raf5rlkq 262 20 lysosomal lysosomal JJ cord-302316-raf5rlkq 262 21 cathepsin cathepsin NN cord-302316-raf5rlkq 262 22 CatB CatB NNP cord-302316-raf5rlkq 262 23 / / SYM cord-302316-raf5rlkq 262 24 L L NNP cord-302316-raf5rlkq 262 25 or or CC cord-302316-raf5rlkq 262 26 the the DT cord-302316-raf5rlkq 262 27 transmembrane transmembrane NNP cord-302316-raf5rlkq 262 28 protease protease NN cord-302316-raf5rlkq 262 29 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 262 30 . . . cord-302316-raf5rlkq 263 1 The the DT cord-302316-raf5rlkq 263 2 serine serine JJ cord-302316-raf5rlkq 263 3 protease protease NN cord-302316-raf5rlkq 263 4 inhibitor inhibitor NN cord-302316-raf5rlkq 263 5 camostat camostat NN cord-302316-raf5rlkq 263 6 , , , cord-302316-raf5rlkq 263 7 which which WDT cord-302316-raf5rlkq 263 8 is be VBZ cord-302316-raf5rlkq 263 9 a a DT cord-302316-raf5rlkq 263 10 registered registered JJ cord-302316-raf5rlkq 263 11 drug drug NN cord-302316-raf5rlkq 263 12 in in IN cord-302316-raf5rlkq 263 13 Japan Japan NNP cord-302316-raf5rlkq 263 14 for for IN cord-302316-raf5rlkq 263 15 gastroenterology gastroenterology NN cord-302316-raf5rlkq 263 16 problems problem NNS cord-302316-raf5rlkq 263 17 , , , cord-302316-raf5rlkq 263 18 inhibits inhibit VBZ cord-302316-raf5rlkq 263 19 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 263 20 and and CC cord-302316-raf5rlkq 263 21 confers confer VBZ cord-302316-raf5rlkq 263 22 partial partial JJ cord-302316-raf5rlkq 263 23 resistance resistance NN cord-302316-raf5rlkq 263 24 to to IN cord-302316-raf5rlkq 263 25 infection infection NN cord-302316-raf5rlkq 263 26 with with IN cord-302316-raf5rlkq 263 27 SARS SARS NNP cord-302316-raf5rlkq 263 28 - - HYPH cord-302316-raf5rlkq 263 29 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 263 30 , , , cord-302316-raf5rlkq 263 31 and and CC cord-302316-raf5rlkq 263 32 total total JJ cord-302316-raf5rlkq 263 33 protection protection NN cord-302316-raf5rlkq 263 34 when when WRB cord-302316-raf5rlkq 263 35 combined combine VBN cord-302316-raf5rlkq 263 36 with with IN cord-302316-raf5rlkq 263 37 E-64d E-64d NNP cord-302316-raf5rlkq 263 38 , , , cord-302316-raf5rlkq 263 39 an an DT cord-302316-raf5rlkq 263 40 inhibitor inhibitor NN cord-302316-raf5rlkq 263 41 of of IN cord-302316-raf5rlkq 263 42 CatB CatB NNP cord-302316-raf5rlkq 263 43 / / SYM cord-302316-raf5rlkq 263 44 L L NNP cord-302316-raf5rlkq 263 45 ( ( -LRB- cord-302316-raf5rlkq 263 46 Hoffmann Hoffmann NNP cord-302316-raf5rlkq 263 47 et et NNP cord-302316-raf5rlkq 263 48 al al NNP cord-302316-raf5rlkq 263 49 . . NNP cord-302316-raf5rlkq 263 50 , , , cord-302316-raf5rlkq 263 51 2020 2020 CD cord-302316-raf5rlkq 263 52 ) ) -RRB- cord-302316-raf5rlkq 263 53 . . . cord-302316-raf5rlkq 264 1 Chinese chinese JJ cord-302316-raf5rlkq 264 2 scientists scientist NNS cord-302316-raf5rlkq 264 3 have have VBP cord-302316-raf5rlkq 264 4 targeted target VBN cord-302316-raf5rlkq 264 5 the the DT cord-302316-raf5rlkq 264 6 SARS SARS NNP cord-302316-raf5rlkq 264 7 - - HYPH cord-302316-raf5rlkq 264 8 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 264 9 main main JJ cord-302316-raf5rlkq 264 10 protease protease NN cord-302316-raf5rlkq 264 11 for for IN cord-302316-raf5rlkq 264 12 inhibition inhibition NN cord-302316-raf5rlkq 264 13 . . . cord-302316-raf5rlkq 265 1 After after IN cord-302316-raf5rlkq 265 2 expressing express VBG cord-302316-raf5rlkq 265 3 the the DT cord-302316-raf5rlkq 265 4 protease protease NN cord-302316-raf5rlkq 265 5 and and CC cord-302316-raf5rlkq 265 6 designing design VBG cord-302316-raf5rlkq 265 7 a a DT cord-302316-raf5rlkq 265 8 fluorescence fluorescence NN cord-302316-raf5rlkq 265 9 - - HYPH cord-302316-raf5rlkq 265 10 labelled label VBN cord-302316-raf5rlkq 265 11 substrate substrate NN cord-302316-raf5rlkq 265 12 , , , cord-302316-raf5rlkq 265 13 they -PRON- PRP cord-302316-raf5rlkq 265 14 used use VBD cord-302316-raf5rlkq 265 15 , , , cord-302316-raf5rlkq 265 16 as as IN cord-302316-raf5rlkq 265 17 an an DT cord-302316-raf5rlkq 265 18 inhibitor inhibitor NN cord-302316-raf5rlkq 265 19 , , , cord-302316-raf5rlkq 265 20 compound compound NN cord-302316-raf5rlkq 265 21 N3 n3 NN cord-302316-raf5rlkq 265 22 which which WDT cord-302316-raf5rlkq 265 23 was be VBD cord-302316-raf5rlkq 265 24 active active JJ cord-302316-raf5rlkq 265 25 against against IN cord-302316-raf5rlkq 265 26 SARS SARS NNP cord-302316-raf5rlkq 265 27 - - HYPH cord-302316-raf5rlkq 265 28 CoV. CoV. NNP cord-302316-raf5rlkq 266 1 In in IN cord-302316-raf5rlkq 266 2 silico silico NN cord-302316-raf5rlkq 266 3 docking docking NN cord-302316-raf5rlkq 266 4 verified verify VBN cord-302316-raf5rlkq 266 5 that that IN cord-302316-raf5rlkq 266 6 it -PRON- PRP cord-302316-raf5rlkq 266 7 could could MD cord-302316-raf5rlkq 266 8 fit fit VB cord-302316-raf5rlkq 266 9 into into IN cord-302316-raf5rlkq 266 10 the the DT cord-302316-raf5rlkq 266 11 predicted predict VBN cord-302316-raf5rlkq 266 12 structure structure NN cord-302316-raf5rlkq 266 13 of of IN cord-302316-raf5rlkq 266 14 SARS SARS NNP cord-302316-raf5rlkq 266 15 - - HYPH cord-302316-raf5rlkq 266 16 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 266 17 main main JJ cord-302316-raf5rlkq 266 18 protease protease NN cord-302316-raf5rlkq 266 19 . . . cord-302316-raf5rlkq 267 1 Kinetic kinetic JJ cord-302316-raf5rlkq 267 2 analysis analysis NN cord-302316-raf5rlkq 267 3 revealed reveal VBD cord-302316-raf5rlkq 267 4 a a DT cord-302316-raf5rlkq 267 5 two two CD cord-302316-raf5rlkq 267 6 - - HYPH cord-302316-raf5rlkq 267 7 step step NN cord-302316-raf5rlkq 267 8 inactivation inactivation NN cord-302316-raf5rlkq 267 9 process process NN cord-302316-raf5rlkq 267 10 resulting result VBG cord-302316-raf5rlkq 267 11 in in IN cord-302316-raf5rlkq 267 12 N3 n3 NN cord-302316-raf5rlkq 267 13 covalent covalent NN cord-302316-raf5rlkq 267 14 binding bind VBG cord-302316-raf5rlkq 267 15 to to IN cord-302316-raf5rlkq 267 16 the the DT cord-302316-raf5rlkq 267 17 catalytic catalytic JJ cord-302316-raf5rlkq 267 18 site site NN cord-302316-raf5rlkq 267 19 . . . cord-302316-raf5rlkq 268 1 The the DT cord-302316-raf5rlkq 268 2 crystal crystal NN cord-302316-raf5rlkq 268 3 structure structure NN cord-302316-raf5rlkq 268 4 for for IN cord-302316-raf5rlkq 268 5 the the DT cord-302316-raf5rlkq 268 6 protease protease NN cord-302316-raf5rlkq 268 7 - - HYPH cord-302316-raf5rlkq 268 8 bound bind VBN cord-302316-raf5rlkq 268 9 N3 n3 NN cord-302316-raf5rlkq 268 10 was be VBD cord-302316-raf5rlkq 268 11 solved solve VBN cord-302316-raf5rlkq 268 12 and and CC cord-302316-raf5rlkq 268 13 was be VBD cord-302316-raf5rlkq 268 14 followed follow VBN cord-302316-raf5rlkq 268 15 by by IN cord-302316-raf5rlkq 268 16 a a DT cord-302316-raf5rlkq 268 17 virtual virtual JJ cord-302316-raf5rlkq 268 18 screening screening NN cord-302316-raf5rlkq 268 19 of of IN cord-302316-raf5rlkq 268 20 a a DT cord-302316-raf5rlkq 268 21 chemical chemical JJ cord-302316-raf5rlkq 268 22 database database NN cord-302316-raf5rlkq 268 23 for for IN cord-302316-raf5rlkq 268 24 better well JJR cord-302316-raf5rlkq 268 25 inhibitors inhibitor NNS cord-302316-raf5rlkq 268 26 . . . cord-302316-raf5rlkq 269 1 The the DT cord-302316-raf5rlkq 269 2 next next JJ cord-302316-raf5rlkq 269 3 step step NN cord-302316-raf5rlkq 269 4 was be VBD cord-302316-raf5rlkq 269 5 a a DT cord-302316-raf5rlkq 269 6 highthroughput highthroughput NN cord-302316-raf5rlkq 269 7 screening screening NN cord-302316-raf5rlkq 269 8 of of IN cord-302316-raf5rlkq 269 9 10'000 10'000 CD cord-302316-raf5rlkq 269 10 compounds compound NNS cord-302316-raf5rlkq 269 11 . . . cord-302316-raf5rlkq 270 1 One one CD cord-302316-raf5rlkq 270 2 of of IN cord-302316-raf5rlkq 270 3 the the DT cord-302316-raf5rlkq 270 4 best good JJS cord-302316-raf5rlkq 270 5 inhibitors inhibitor NNS cord-302316-raf5rlkq 270 6 was be VBD cord-302316-raf5rlkq 270 7 an an DT cord-302316-raf5rlkq 270 8 organo organo NN cord-302316-raf5rlkq 270 9 - - HYPH cord-302316-raf5rlkq 270 10 selenium selenium NN cord-302316-raf5rlkq 270 11 compound compound NN cord-302316-raf5rlkq 270 12 that that WDT cord-302316-raf5rlkq 270 13 inhibited inhibit VBD cord-302316-raf5rlkq 270 14 the the DT cord-302316-raf5rlkq 270 15 infectivity infectivity NN cord-302316-raf5rlkq 270 16 of of IN cord-302316-raf5rlkq 270 17 SARS SARS NNP cord-302316-raf5rlkq 270 18 - - HYPH cord-302316-raf5rlkq 270 19 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 270 20 in in IN cord-302316-raf5rlkq 270 21 a a DT cord-302316-raf5rlkq 270 22 cell cell NN cord-302316-raf5rlkq 270 23 culture culture NN cord-302316-raf5rlkq 270 24 test test NN cord-302316-raf5rlkq 270 25 . . . cord-302316-raf5rlkq 271 1 Since since IN cord-302316-raf5rlkq 271 2 this this DT cord-302316-raf5rlkq 271 3 compound compound NN cord-302316-raf5rlkq 271 4 has have VBZ cord-302316-raf5rlkq 271 5 already already RB cord-302316-raf5rlkq 271 6 been be VBN cord-302316-raf5rlkq 271 7 investigated investigate VBN cord-302316-raf5rlkq 271 8 for for IN cord-302316-raf5rlkq 271 9 the the DT cord-302316-raf5rlkq 271 10 treatment treatment NN cord-302316-raf5rlkq 271 11 of of IN cord-302316-raf5rlkq 271 12 several several JJ cord-302316-raf5rlkq 271 13 diseases disease NNS cord-302316-raf5rlkq 271 14 , , , cord-302316-raf5rlkq 271 15 where where WRB cord-302316-raf5rlkq 271 16 it -PRON- PRP cord-302316-raf5rlkq 271 17 showed show VBD cord-302316-raf5rlkq 271 18 a a DT cord-302316-raf5rlkq 271 19 high high JJ cord-302316-raf5rlkq 271 20 safety safety NN cord-302316-raf5rlkq 271 21 profile profile NN cord-302316-raf5rlkq 271 22 , , , cord-302316-raf5rlkq 271 23 this this DT cord-302316-raf5rlkq 271 24 repurposed repurpose VBN cord-302316-raf5rlkq 271 25 drug drug NN cord-302316-raf5rlkq 271 26 could could MD cord-302316-raf5rlkq 271 27 be be VB cord-302316-raf5rlkq 271 28 re re VBN cord-302316-raf5rlkq 271 29 - - VBN cord-302316-raf5rlkq 271 30 entered enter VBN cord-302316-raf5rlkq 271 31 into into IN cord-302316-raf5rlkq 271 32 clinical clinical JJ cord-302316-raf5rlkq 271 33 trials trial NNS cord-302316-raf5rlkq 271 34 relatively relatively RB cord-302316-raf5rlkq 271 35 quickly quickly RB cord-302316-raf5rlkq 271 36 . . . cord-302316-raf5rlkq 272 1 US US NNP cord-302316-raf5rlkq 272 2 researchers researcher NNS cord-302316-raf5rlkq 272 3 have have VBP cord-302316-raf5rlkq 272 4 expressed express VBN cord-302316-raf5rlkq 272 5 in in IN cord-302316-raf5rlkq 272 6 a a DT cord-302316-raf5rlkq 272 7 cell cell NN cord-302316-raf5rlkq 272 8 culture culture NN cord-302316-raf5rlkq 272 9 system system NN cord-302316-raf5rlkq 272 10 all all DT cord-302316-raf5rlkq 272 11 of of IN cord-302316-raf5rlkq 272 12 the the DT cord-302316-raf5rlkq 272 13 SARS SARS NNP cord-302316-raf5rlkq 272 14 - - HYPH cord-302316-raf5rlkq 272 15 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 272 16 proteins protein NNS cord-302316-raf5rlkq 272 17 that that WDT cord-302316-raf5rlkq 272 18 were be VBD cord-302316-raf5rlkq 272 19 tagged tag VBN cord-302316-raf5rlkq 272 20 with with IN cord-302316-raf5rlkq 272 21 a a DT cord-302316-raf5rlkq 272 22 recognition recognition NN cord-302316-raf5rlkq 272 23 peptide peptide NN cord-302316-raf5rlkq 272 24 , , , cord-302316-raf5rlkq 272 25 which which WDT cord-302316-raf5rlkq 272 26 allowed allow VBD cord-302316-raf5rlkq 272 27 the the DT cord-302316-raf5rlkq 272 28 isolation isolation NN cord-302316-raf5rlkq 272 29 of of IN cord-302316-raf5rlkq 272 30 cellular cellular JJ cord-302316-raf5rlkq 272 31 proteins protein NNS cord-302316-raf5rlkq 272 32 interacting interact VBG cord-302316-raf5rlkq 272 33 with with IN cord-302316-raf5rlkq 272 34 the the DT cord-302316-raf5rlkq 272 35 viral viral JJ cord-302316-raf5rlkq 272 36 bait bait NN cord-302316-raf5rlkq 272 37 protein protein NN cord-302316-raf5rlkq 272 38 . . . cord-302316-raf5rlkq 273 1 The the DT cord-302316-raf5rlkq 273 2 protein protein NN cord-302316-raf5rlkq 273 3 complexes complex NNS cord-302316-raf5rlkq 273 4 were be VBD cord-302316-raf5rlkq 273 5 collected collect VBN cord-302316-raf5rlkq 273 6 by by IN cord-302316-raf5rlkq 273 7 affinity affinity NN cord-302316-raf5rlkq 273 8 chromatography chromatography NN cord-302316-raf5rlkq 273 9 , , , cord-302316-raf5rlkq 273 10 and and CC cord-302316-raf5rlkq 273 11 the the DT cord-302316-raf5rlkq 273 12 copurified copurifie VBN cord-302316-raf5rlkq 273 13 cellular cellular JJ cord-302316-raf5rlkq 273 14 proteins protein NNS cord-302316-raf5rlkq 273 15 were be VBD cord-302316-raf5rlkq 273 16 identified identify VBN cord-302316-raf5rlkq 273 17 by by IN cord-302316-raf5rlkq 273 18 mass mass NN cord-302316-raf5rlkq 273 19 spectrometry spectrometry NN cord-302316-raf5rlkq 273 20 . . . cord-302316-raf5rlkq 274 1 This this DT cord-302316-raf5rlkq 274 2 approach approach NN cord-302316-raf5rlkq 274 3 yielded yield VBD cord-302316-raf5rlkq 274 4 332 332 CD cord-302316-raf5rlkq 274 5 highconfidence highconfidence NN cord-302316-raf5rlkq 274 6 protein protein NN cord-302316-raf5rlkq 274 7 - - HYPH cord-302316-raf5rlkq 274 8 protein protein NN cord-302316-raf5rlkq 274 9 interaction interaction NN cord-302316-raf5rlkq 274 10 partners partner NNS cord-302316-raf5rlkq 274 11 . . . cord-302316-raf5rlkq 275 1 The the DT cord-302316-raf5rlkq 275 2 captured capture VBN cord-302316-raf5rlkq 275 3 proteins protein NNS cord-302316-raf5rlkq 275 4 showed show VBD cord-302316-raf5rlkq 275 5 high high JJ cord-302316-raf5rlkq 275 6 expression expression NN cord-302316-raf5rlkq 275 7 in in IN cord-302316-raf5rlkq 275 8 lung lung NN cord-302316-raf5rlkq 275 9 tissue tissue NN cord-302316-raf5rlkq 275 10 , , , cord-302316-raf5rlkq 275 11 and and CC cord-302316-raf5rlkq 275 12 many many JJ cord-302316-raf5rlkq 275 13 of of IN cord-302316-raf5rlkq 275 14 them -PRON- PRP cord-302316-raf5rlkq 275 15 also also RB cord-302316-raf5rlkq 275 16 interacted interact VBD cord-302316-raf5rlkq 275 17 with with IN cord-302316-raf5rlkq 275 18 another another DT cord-302316-raf5rlkq 275 19 lung lung NN cord-302316-raf5rlkq 275 20 pathogen pathogen NN cord-302316-raf5rlkq 275 21 , , , cord-302316-raf5rlkq 275 22 Mycobacterium Mycobacterium NNP cord-302316-raf5rlkq 275 23 tuberculosis tuberculosis NN cord-302316-raf5rlkq 275 24 . . . cord-302316-raf5rlkq 276 1 The the DT cord-302316-raf5rlkq 276 2 viral viral JJ cord-302316-raf5rlkq 276 3 proteins protein NNS cord-302316-raf5rlkq 276 4 interacted interact VBN cord-302316-raf5rlkq 276 5 with with IN cord-302316-raf5rlkq 276 6 proteins protein NNS cord-302316-raf5rlkq 276 7 from from IN cord-302316-raf5rlkq 276 8 multiple multiple JJ cord-302316-raf5rlkq 276 9 innate innate JJ cord-302316-raf5rlkq 276 10 immune immune JJ cord-302316-raf5rlkq 276 11 pathways pathway NNS cord-302316-raf5rlkq 276 12 , , , cord-302316-raf5rlkq 276 13 the the DT cord-302316-raf5rlkq 276 14 host host NN cord-302316-raf5rlkq 276 15 translation translation NN cord-302316-raf5rlkq 276 16 machinery machinery NN cord-302316-raf5rlkq 276 17 , , , cord-302316-raf5rlkq 276 18 the the DT cord-302316-raf5rlkq 276 19 ubiquitin ubiquitin NN cord-302316-raf5rlkq 276 20 ligase ligase NN cord-302316-raf5rlkq 276 21 complex complex NN cord-302316-raf5rlkq 276 22 and and CC cord-302316-raf5rlkq 276 23 proteins protein NNS cord-302316-raf5rlkq 276 24 involved involve VBN cord-302316-raf5rlkq 276 25 in in IN cord-302316-raf5rlkq 276 26 transcriptional transcriptional JJ cord-302316-raf5rlkq 276 27 regulation regulation NN cord-302316-raf5rlkq 276 28 of of IN cord-302316-raf5rlkq 276 29 antiviral antiviral JJ cord-302316-raf5rlkq 276 30 responses response NNS cord-302316-raf5rlkq 276 31 . . . cord-302316-raf5rlkq 277 1 From from IN cord-302316-raf5rlkq 277 2 a a DT cord-302316-raf5rlkq 277 3 search search NN cord-302316-raf5rlkq 277 4 of of IN cord-302316-raf5rlkq 277 5 chemical chemical NN cord-302316-raf5rlkq 277 6 databases database NNS cord-302316-raf5rlkq 277 7 , , , cord-302316-raf5rlkq 277 8 the the DT cord-302316-raf5rlkq 277 9 scientists scientist NNS cord-302316-raf5rlkq 277 10 identified identify VBD cord-302316-raf5rlkq 277 11 69 69 CD cord-302316-raf5rlkq 277 12 ligands ligand NNS cord-302316-raf5rlkq 277 13 , , , cord-302316-raf5rlkq 277 14 including include VBG cord-302316-raf5rlkq 277 15 FDA FDA NNP cord-302316-raf5rlkq 277 16 - - HYPH cord-302316-raf5rlkq 277 17 approved approve VBN cord-302316-raf5rlkq 277 18 drugs drug NNS cord-302316-raf5rlkq 277 19 and and CC cord-302316-raf5rlkq 277 20 compounds compound NNS cord-302316-raf5rlkq 277 21 currently currently RB cord-302316-raf5rlkq 277 22 used use VBN cord-302316-raf5rlkq 277 23 in in IN cord-302316-raf5rlkq 277 24 clinical clinical JJ cord-302316-raf5rlkq 277 25 trials trial NNS cord-302316-raf5rlkq 277 26 that that WDT cord-302316-raf5rlkq 277 27 interacted interact VBD cord-302316-raf5rlkq 277 28 with with IN cord-302316-raf5rlkq 277 29 the the DT cord-302316-raf5rlkq 277 30 identified identify VBN cord-302316-raf5rlkq 277 31 proteins protein NNS cord-302316-raf5rlkq 277 32 . . . cord-302316-raf5rlkq 278 1 In in IN cord-302316-raf5rlkq 278 2 cell cell NN cord-302316-raf5rlkq 278 3 culture culture NN cord-302316-raf5rlkq 278 4 , , , cord-302316-raf5rlkq 278 5 several several JJ cord-302316-raf5rlkq 278 6 compounds compound NNS cord-302316-raf5rlkq 278 7 showed show VBD cord-302316-raf5rlkq 278 8 inhibitory inhibitory JJ cord-302316-raf5rlkq 278 9 activity activity NN cord-302316-raf5rlkq 278 10 against against IN cord-302316-raf5rlkq 278 11 SARS SARS NNP cord-302316-raf5rlkq 278 12 - - HYPH cord-302316-raf5rlkq 278 13 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 278 14 . . . cord-302316-raf5rlkq 279 1 The the DT cord-302316-raf5rlkq 279 2 candidate candidate NN cord-302316-raf5rlkq 279 3 inhibitors inhibitor NNS cord-302316-raf5rlkq 279 4 included include VBD cord-302316-raf5rlkq 279 5 the the DT cord-302316-raf5rlkq 279 6 following follow VBG cord-302316-raf5rlkq 279 7 : : : cord-302316-raf5rlkq 279 8 antihistamines antihistamine NNS cord-302316-raf5rlkq 279 9 , , , cord-302316-raf5rlkq 279 10 antitussives antitussive NNS cord-302316-raf5rlkq 279 11 , , , cord-302316-raf5rlkq 279 12 antipsychotics antipsychotic NNS cord-302316-raf5rlkq 279 13 and and CC cord-302316-raf5rlkq 279 14 interestingly interestingly RB cord-302316-raf5rlkq 279 15 also also RB cord-302316-raf5rlkq 279 16 hydroxychloroquine hydroxychloroquine VBP cord-302316-raf5rlkq 279 17 ( ( -LRB- cord-302316-raf5rlkq 279 18 Gordon Gordon NNP cord-302316-raf5rlkq 279 19 et et NNP cord-302316-raf5rlkq 279 20 al al NNP cord-302316-raf5rlkq 279 21 . . NNP cord-302316-raf5rlkq 279 22 , , , cord-302316-raf5rlkq 279 23 2020 2020 CD cord-302316-raf5rlkq 279 24 ) ) -RRB- cord-302316-raf5rlkq 279 25 . . . cord-302316-raf5rlkq 280 1 Parallel parallel JJ cord-302316-raf5rlkq 280 2 to to IN cord-302316-raf5rlkq 280 3 these these DT cord-302316-raf5rlkq 280 4 state state NN cord-302316-raf5rlkq 280 5 - - HYPH cord-302316-raf5rlkq 280 6 of of IN cord-302316-raf5rlkq 280 7 - - HYPH cord-302316-raf5rlkq 280 8 the the DT cord-302316-raf5rlkq 280 9 - - HYPH cord-302316-raf5rlkq 280 10 art art NN cord-302316-raf5rlkq 280 11 biochemical biochemical JJ cord-302316-raf5rlkq 280 12 approaches approach NNS cord-302316-raf5rlkq 280 13 , , , cord-302316-raf5rlkq 280 14 one one PRP cord-302316-raf5rlkq 280 15 must must MD cord-302316-raf5rlkq 280 16 also also RB cord-302316-raf5rlkq 280 17 mention mention VB cord-302316-raf5rlkq 280 18 the the DT cord-302316-raf5rlkq 280 19 traditional traditional JJ cord-302316-raf5rlkq 280 20 approaches approach NNS cord-302316-raf5rlkq 280 21 promoted promote VBN cord-302316-raf5rlkq 280 22 in in IN cord-302316-raf5rlkq 280 23 China China NNP cord-302316-raf5rlkq 280 24 . . . cord-302316-raf5rlkq 281 1 According accord VBG cord-302316-raf5rlkq 281 2 to to IN cord-302316-raf5rlkq 281 3 Chinese chinese JJ cord-302316-raf5rlkq 281 4 state state NN cord-302316-raf5rlkq 281 5 media medium NNS cord-302316-raf5rlkq 281 6 , , , cord-302316-raf5rlkq 281 7 Jinhua Jinhua NNP cord-302316-raf5rlkq 281 8 Qinggan Qinggan NNP cord-302316-raf5rlkq 281 9 herbal herbal JJ cord-302316-raf5rlkq 281 10 granules granule NNS cord-302316-raf5rlkq 281 11 accelerated accelerate VBN cord-302316-raf5rlkq 281 12 , , , cord-302316-raf5rlkq 281 13 in in IN cord-302316-raf5rlkq 281 14 a a DT cord-302316-raf5rlkq 281 15 clinical clinical JJ cord-302316-raf5rlkq 281 16 trial trial NN cord-302316-raf5rlkq 281 17 with with IN cord-302316-raf5rlkq 281 18 COVID-19 covid-19 JJ cord-302316-raf5rlkq 281 19 patients patient NNS cord-302316-raf5rlkq 281 20 , , , cord-302316-raf5rlkq 281 21 conversion conversion NN cord-302316-raf5rlkq 281 22 to to IN cord-302316-raf5rlkq 281 23 a a DT cord-302316-raf5rlkq 281 24 negative negative JJ cord-302316-raf5rlkq 281 25 virus virus NN cord-302316-raf5rlkq 281 26 test test NN cord-302316-raf5rlkq 281 27 within within IN cord-302316-raf5rlkq 281 28 2 2 CD cord-302316-raf5rlkq 281 29 days day NNS cord-302316-raf5rlkq 281 30 . . . cord-302316-raf5rlkq 282 1 Xuebijing Xuebijing NNP cord-302316-raf5rlkq 282 2 , , , cord-302316-raf5rlkq 282 3 an an DT cord-302316-raf5rlkq 282 4 extract extract NN cord-302316-raf5rlkq 282 5 of of IN cord-302316-raf5rlkq 282 6 five five CD cord-302316-raf5rlkq 282 7 herbs herb NNS cord-302316-raf5rlkq 282 8 , , , cord-302316-raf5rlkq 282 9 reduced reduce VBN cord-302316-raf5rlkq 282 10 mortality mortality NN cord-302316-raf5rlkq 282 11 in in IN cord-302316-raf5rlkq 282 12 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 282 13 by by IN cord-302316-raf5rlkq 282 14 8.8 8.8 CD cord-302316-raf5rlkq 282 15 % % NN cord-302316-raf5rlkq 282 16 via via IN cord-302316-raf5rlkq 282 17 removing remove VBG cord-302316-raf5rlkq 282 18 blood blood NN cord-302316-raf5rlkq 282 19 stasis stasis NN cord-302316-raf5rlkq 282 20 . . . cord-302316-raf5rlkq 283 1 Details detail NNS cord-302316-raf5rlkq 283 2 of of IN cord-302316-raf5rlkq 283 3 these these DT cord-302316-raf5rlkq 283 4 trials trial NNS cord-302316-raf5rlkq 283 5 are be VBP cord-302316-raf5rlkq 283 6 not not RB cord-302316-raf5rlkq 283 7 yet yet RB cord-302316-raf5rlkq 283 8 available available JJ cord-302316-raf5rlkq 284 1 ( ( -LRB- cord-302316-raf5rlkq 284 2 Cyranosky Cyranosky NNP cord-302316-raf5rlkq 284 3 , , , cord-302316-raf5rlkq 284 4 2020 2020 CD cord-302316-raf5rlkq 284 5 ) ) -RRB- cord-302316-raf5rlkq 284 6 . . . cord-302316-raf5rlkq 285 1 In in IN cord-302316-raf5rlkq 285 2 the the DT cord-302316-raf5rlkq 285 3 emergency emergency NN cord-302316-raf5rlkq 285 4 situation situation NN cord-302316-raf5rlkq 285 5 of of IN cord-302316-raf5rlkq 285 6 the the DT cord-302316-raf5rlkq 285 7 expanding expand VBG cord-302316-raf5rlkq 285 8 pandemic pandemic NN cord-302316-raf5rlkq 285 9 and and CC cord-302316-raf5rlkq 285 10 in in IN cord-302316-raf5rlkq 285 11 an an DT cord-302316-raf5rlkq 285 12 effort effort NN cord-302316-raf5rlkq 285 13 to to TO cord-302316-raf5rlkq 285 14 save save VB cord-302316-raf5rlkq 285 15 lives life NNS cord-302316-raf5rlkq 285 16 , , , cord-302316-raf5rlkq 285 17 severe severe JJ cord-302316-raf5rlkq 285 18 COVID-19 covid-19 JJ cord-302316-raf5rlkq 285 19 cases case NNS cord-302316-raf5rlkq 285 20 were be VBD cord-302316-raf5rlkq 285 21 frequently frequently RB cord-302316-raf5rlkq 285 22 treated treat VBN cord-302316-raf5rlkq 285 23 with with IN cord-302316-raf5rlkq 285 24 many many JJ cord-302316-raf5rlkq 285 25 different different JJ cord-302316-raf5rlkq 285 26 drugs drug NNS cord-302316-raf5rlkq 285 27 . . . cord-302316-raf5rlkq 286 1 This this DT cord-302316-raf5rlkq 286 2 situation situation NN cord-302316-raf5rlkq 286 3 leads lead VBZ cord-302316-raf5rlkq 286 4 to to IN cord-302316-raf5rlkq 286 5 complex complex JJ cord-302316-raf5rlkq 286 6 drug drug NN cord-302316-raf5rlkq 286 7 interaction interaction NN cord-302316-raf5rlkq 286 8 , , , cord-302316-raf5rlkq 286 9 potential potential JJ cord-302316-raf5rlkq 286 10 detrimental detrimental JJ cord-302316-raf5rlkq 286 11 side side NN cord-302316-raf5rlkq 286 12 effects effect NNS cord-302316-raf5rlkq 286 13 for for IN cord-302316-raf5rlkq 286 14 the the DT cord-302316-raf5rlkq 286 15 patients patient NNS cord-302316-raf5rlkq 286 16 and and CC cord-302316-raf5rlkq 286 17 difficulty difficulty NN cord-302316-raf5rlkq 286 18 to to TO cord-302316-raf5rlkq 286 19 disentangle disentangle VB cord-302316-raf5rlkq 286 20 the the DT cord-302316-raf5rlkq 286 21 effect effect NN cord-302316-raf5rlkq 286 22 of of IN cord-302316-raf5rlkq 286 23 tested test VBN cord-302316-raf5rlkq 286 24 drugs drug NNS cord-302316-raf5rlkq 286 25 in in IN cord-302316-raf5rlkq 286 26 clinical clinical JJ cord-302316-raf5rlkq 286 27 trials trial NNS cord-302316-raf5rlkq 286 28 from from IN cord-302316-raf5rlkq 286 29 concomitant concomitant JJ cord-302316-raf5rlkq 286 30 treatment treatment NN cord-302316-raf5rlkq 286 31 . . . cord-302316-raf5rlkq 287 1 The the DT cord-302316-raf5rlkq 287 2 extent extent NN cord-302316-raf5rlkq 287 3 of of IN cord-302316-raf5rlkq 287 4 the the DT cord-302316-raf5rlkq 287 5 pandemic pandemic NN cord-302316-raf5rlkq 287 6 also also RB cord-302316-raf5rlkq 287 7 led lead VBD cord-302316-raf5rlkq 287 8 to to IN cord-302316-raf5rlkq 287 9 questions question NNS cord-302316-raf5rlkq 287 10 about about IN cord-302316-raf5rlkq 287 11 whether whether IN cord-302316-raf5rlkq 287 12 the the DT cord-302316-raf5rlkq 287 13 drug drug NN cord-302316-raf5rlkq 287 14 treatment treatment NN cord-302316-raf5rlkq 287 15 for for IN cord-302316-raf5rlkq 287 16 existing exist VBG cord-302316-raf5rlkq 287 17 morbidities morbidity NNS cord-302316-raf5rlkq 287 18 of of IN cord-302316-raf5rlkq 287 19 the the DT cord-302316-raf5rlkq 287 20 patients patient NNS cord-302316-raf5rlkq 287 21 increased increase VBD cord-302316-raf5rlkq 287 22 the the DT cord-302316-raf5rlkq 287 23 risk risk NN cord-302316-raf5rlkq 287 24 for for IN cord-302316-raf5rlkq 287 25 SARS SARS NNP cord-302316-raf5rlkq 287 26 - - HYPH cord-302316-raf5rlkq 287 27 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 287 28 infections infection NNS cord-302316-raf5rlkq 287 29 , , , cord-302316-raf5rlkq 287 30 or or CC cord-302316-raf5rlkq 287 31 even even RB cord-302316-raf5rlkq 287 32 led lead VBN cord-302316-raf5rlkq 287 33 to to IN cord-302316-raf5rlkq 287 34 a a DT cord-302316-raf5rlkq 287 35 more more RBR cord-302316-raf5rlkq 287 36 severe severe JJ cord-302316-raf5rlkq 287 37 clinical clinical JJ cord-302316-raf5rlkq 287 38 course course NN cord-302316-raf5rlkq 287 39 . . . cord-302316-raf5rlkq 288 1 From from IN cord-302316-raf5rlkq 288 2 the the DT cord-302316-raf5rlkq 288 3 large large JJ cord-302316-raf5rlkq 288 4 selection selection NN cord-302316-raf5rlkq 288 5 of of IN cord-302316-raf5rlkq 288 6 literature literature NN cord-302316-raf5rlkq 288 7 about about IN cord-302316-raf5rlkq 288 8 treatment treatment NN cord-302316-raf5rlkq 288 9 of of IN cord-302316-raf5rlkq 288 10 other other JJ cord-302316-raf5rlkq 288 11 diseases disease NNS cord-302316-raf5rlkq 288 12 during during IN cord-302316-raf5rlkq 288 13 the the DT cord-302316-raf5rlkq 288 14 COVID-19 covid-19 JJ cord-302316-raf5rlkq 288 15 epidemic epidemic NN cord-302316-raf5rlkq 288 16 , , , cord-302316-raf5rlkq 288 17 I -PRON- PRP cord-302316-raf5rlkq 288 18 have have VBP cord-302316-raf5rlkq 288 19 selected select VBN cord-302316-raf5rlkq 288 20 one one CD cord-302316-raf5rlkq 288 21 which which WDT cord-302316-raf5rlkq 288 22 was be VBD cord-302316-raf5rlkq 288 23 cited cite VBN cord-302316-raf5rlkq 288 24 as as IN cord-302316-raf5rlkq 288 25 a a DT cord-302316-raf5rlkq 288 26 major major JJ cord-302316-raf5rlkq 288 27 risk risk NN cord-302316-raf5rlkq 288 28 for for IN cord-302316-raf5rlkq 288 29 developing develop VBG cord-302316-raf5rlkq 288 30 severe severe JJ cord-302316-raf5rlkq 288 31 COVID-19 covid-19 JJ cord-302316-raf5rlkq 288 32 , , , cord-302316-raf5rlkq 288 33 namely namely RB cord-302316-raf5rlkq 288 34 hypertension hypertension NN cord-302316-raf5rlkq 288 35 . . . cord-302316-raf5rlkq 289 1 ACE-2 ACE-2 NNP cord-302316-raf5rlkq 289 2 is be VBZ cord-302316-raf5rlkq 289 3 the the DT cord-302316-raf5rlkq 289 4 cellular cellular JJ cord-302316-raf5rlkq 289 5 receptor receptor NN cord-302316-raf5rlkq 289 6 of of IN cord-302316-raf5rlkq 289 7 SARS SARS NNP cord-302316-raf5rlkq 289 8 - - HYPH cord-302316-raf5rlkq 289 9 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 289 10 , , , cord-302316-raf5rlkq 289 11 and and CC cord-302316-raf5rlkq 289 12 it -PRON- PRP cord-302316-raf5rlkq 289 13 is be VBZ cord-302316-raf5rlkq 289 14 the the DT cord-302316-raf5rlkq 289 15 target target NN cord-302316-raf5rlkq 289 16 for for IN cord-302316-raf5rlkq 289 17 a a DT cord-302316-raf5rlkq 289 18 class class NN cord-302316-raf5rlkq 289 19 of of IN cord-302316-raf5rlkq 289 20 antihypertensive antihypertensive JJ cord-302316-raf5rlkq 289 21 drugs drug NNS cord-302316-raf5rlkq 289 22 that that WDT cord-302316-raf5rlkq 289 23 block block VBP cord-302316-raf5rlkq 289 24 this this DT cord-302316-raf5rlkq 289 25 enzyme enzyme NN cord-302316-raf5rlkq 289 26 , , , cord-302316-raf5rlkq 289 27 which which WDT cord-302316-raf5rlkq 289 28 leads lead VBZ cord-302316-raf5rlkq 289 29 to to IN cord-302316-raf5rlkq 289 30 its -PRON- PRP$ cord-302316-raf5rlkq 289 31 increased increased JJ cord-302316-raf5rlkq 289 32 expression expression NN cord-302316-raf5rlkq 289 33 . . . cord-302316-raf5rlkq 290 1 Since since IN cord-302316-raf5rlkq 290 2 hypertension hypertension NN cord-302316-raf5rlkq 290 3 has have VBZ cord-302316-raf5rlkq 290 4 been be VBN cord-302316-raf5rlkq 290 5 frequently frequently RB cord-302316-raf5rlkq 290 6 reported report VBN cord-302316-raf5rlkq 290 7 as as IN cord-302316-raf5rlkq 290 8 a a DT cord-302316-raf5rlkq 290 9 risk risk NN cord-302316-raf5rlkq 290 10 factor factor NN cord-302316-raf5rlkq 290 11 in in IN cord-302316-raf5rlkq 290 12 severe severe JJ cord-302316-raf5rlkq 290 13 COVID-19 covid-19 JJ cord-302316-raf5rlkq 290 14 infections infection NNS cord-302316-raf5rlkq 290 15 , , , cord-302316-raf5rlkq 290 16 the the DT cord-302316-raf5rlkq 290 17 safety safety NN cord-302316-raf5rlkq 290 18 of of IN cord-302316-raf5rlkq 290 19 antihypertensive antihypertensive JJ cord-302316-raf5rlkq 290 20 drugs drug NNS cord-302316-raf5rlkq 290 21 during during IN cord-302316-raf5rlkq 290 22 the the DT cord-302316-raf5rlkq 290 23 COVID-19 covid-19 JJ cord-302316-raf5rlkq 290 24 epidemic epidemic NN cord-302316-raf5rlkq 290 25 has have VBZ cord-302316-raf5rlkq 290 26 been be VBN cord-302316-raf5rlkq 290 27 questioned question VBN cord-302316-raf5rlkq 290 28 . . . cord-302316-raf5rlkq 291 1 Cardiologists cardiologist NNS cord-302316-raf5rlkq 291 2 studied study VBD cord-302316-raf5rlkq 291 3 this this DT cord-302316-raf5rlkq 291 4 question question NN cord-302316-raf5rlkq 291 5 in in IN cord-302316-raf5rlkq 291 6 New New NNP cord-302316-raf5rlkq 291 7 York York NNP cord-302316-raf5rlkq 291 8 City City NNP cord-302316-raf5rlkq 291 9 , , , cord-302316-raf5rlkq 291 10 an an DT cord-302316-raf5rlkq 291 11 epicentre epicentre NN cord-302316-raf5rlkq 291 12 of of IN cord-302316-raf5rlkq 291 13 this this DT cord-302316-raf5rlkq 291 14 pandemic pandemic NN cord-302316-raf5rlkq 291 15 . . . cord-302316-raf5rlkq 292 1 More More JJR cord-302316-raf5rlkq 292 2 than than IN cord-302316-raf5rlkq 292 3 12'000 12'000 CD cord-302316-raf5rlkq 292 4 cases case NNS cord-302316-raf5rlkq 292 5 were be VBD cord-302316-raf5rlkq 292 6 investigated investigate VBN cord-302316-raf5rlkq 292 7 , , , cord-302316-raf5rlkq 292 8 nearly nearly RB cord-302316-raf5rlkq 292 9 half half NN cord-302316-raf5rlkq 292 10 of of IN cord-302316-raf5rlkq 292 11 them -PRON- PRP cord-302316-raf5rlkq 292 12 had have VBD cord-302316-raf5rlkq 292 13 a a DT cord-302316-raf5rlkq 292 14 positive positive JJ cord-302316-raf5rlkq 292 15 viral viral JJ cord-302316-raf5rlkq 292 16 test test NN cord-302316-raf5rlkq 292 17 . . . cord-302316-raf5rlkq 293 1 From from IN cord-302316-raf5rlkq 293 2 these these DT cord-302316-raf5rlkq 293 3 6'000 6'000 CD cord-302316-raf5rlkq 293 4 cases case NNS cord-302316-raf5rlkq 293 5 , , , cord-302316-raf5rlkq 293 6 1'000 1'000 CD cord-302316-raf5rlkq 293 7 had have VBD cord-302316-raf5rlkq 293 8 severe severe JJ cord-302316-raf5rlkq 293 9 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 293 10 , , , cord-302316-raf5rlkq 293 11 726 726 CD cord-302316-raf5rlkq 293 12 were be VBD cord-302316-raf5rlkq 293 13 in in IN cord-302316-raf5rlkq 293 14 intensive intensive JJ cord-302316-raf5rlkq 293 15 care care NN cord-302316-raf5rlkq 293 16 , , , cord-302316-raf5rlkq 293 17 and and CC cord-302316-raf5rlkq 293 18 447 447 CD cord-302316-raf5rlkq 293 19 died die VBD cord-302316-raf5rlkq 293 20 . . . cord-302316-raf5rlkq 294 1 The the DT cord-302316-raf5rlkq 294 2 researchers researcher NNS cord-302316-raf5rlkq 294 3 ruled rule VBD cord-302316-raf5rlkq 294 4 out out RP cord-302316-raf5rlkq 294 5 a a DT cord-302316-raf5rlkq 294 6 significant significant JJ cord-302316-raf5rlkq 294 7 effect effect NN cord-302316-raf5rlkq 294 8 from from IN cord-302316-raf5rlkq 294 9 any any DT cord-302316-raf5rlkq 294 10 of of IN cord-302316-raf5rlkq 294 11 five five CD cord-302316-raf5rlkq 294 12 common common JJ cord-302316-raf5rlkq 294 13 antihypertensive antihypertensive JJ cord-302316-raf5rlkq 294 14 drugs drug NNS cord-302316-raf5rlkq 294 15 favouring favour VBG cord-302316-raf5rlkq 294 16 infection infection NN cord-302316-raf5rlkq 294 17 ( ( -LRB- cord-302316-raf5rlkq 294 18 i.e. i.e. FW cord-302316-raf5rlkq 294 19 from from IN cord-302316-raf5rlkq 294 20 being be VBG cord-302316-raf5rlkq 294 21 tested test VBN cord-302316-raf5rlkq 294 22 positive positive JJ cord-302316-raf5rlkq 294 23 for for IN cord-302316-raf5rlkq 294 24 SARS SARS NNP cord-302316-raf5rlkq 294 25 - - HYPH cord-302316-raf5rlkq 294 26 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 294 27 ) ) -RRB- cord-302316-raf5rlkq 294 28 or or CC cord-302316-raf5rlkq 294 29 that that IN cord-302316-raf5rlkq 294 30 they -PRON- PRP cord-302316-raf5rlkq 294 31 increase increase VBP cord-302316-raf5rlkq 294 32 the the DT cord-302316-raf5rlkq 294 33 likelihood likelihood NN cord-302316-raf5rlkq 294 34 of of IN cord-302316-raf5rlkq 294 35 inducing induce VBG cord-302316-raf5rlkq 294 36 severe severe JJ cord-302316-raf5rlkq 294 37 COVID-19 covid-19 NN cord-302316-raf5rlkq 294 38 . . . cord-302316-raf5rlkq 295 1 Patients patient NNS cord-302316-raf5rlkq 295 2 taking take VBG cord-302316-raf5rlkq 295 3 beta beta NN cord-302316-raf5rlkq 295 4 - - HYPH cord-302316-raf5rlkq 295 5 blockers blocker NNS cord-302316-raf5rlkq 295 6 even even RB cord-302316-raf5rlkq 295 7 had have VBD cord-302316-raf5rlkq 295 8 a a DT cord-302316-raf5rlkq 295 9 significant significant JJ cord-302316-raf5rlkq 295 10 , , , cord-302316-raf5rlkq 295 11 although although IN cord-302316-raf5rlkq 295 12 marginally marginally RB cord-302316-raf5rlkq 295 13 lower low JJR cord-302316-raf5rlkq 295 14 , , , cord-302316-raf5rlkq 295 15 risk risk NN cord-302316-raf5rlkq 295 16 of of IN cord-302316-raf5rlkq 295 17 testing test VBG cord-302316-raf5rlkq 295 18 positive positive JJ cord-302316-raf5rlkq 295 19 for for IN cord-302316-raf5rlkq 295 20 the the DT cord-302316-raf5rlkq 295 21 virus virus NN cord-302316-raf5rlkq 296 1 ( ( -LRB- cord-302316-raf5rlkq 296 2 Reynolds Reynolds NNP cord-302316-raf5rlkq 296 3 et et NNP cord-302316-raf5rlkq 296 4 al al NNP cord-302316-raf5rlkq 296 5 . . NNP cord-302316-raf5rlkq 296 6 , , , cord-302316-raf5rlkq 296 7 2020 2020 CD cord-302316-raf5rlkq 296 8 ) ) -RRB- cord-302316-raf5rlkq 296 9 . . . cord-302316-raf5rlkq 297 1 The the DT cord-302316-raf5rlkq 297 2 same same JJ cord-302316-raf5rlkq 297 3 question question NN cord-302316-raf5rlkq 297 4 was be VBD cord-302316-raf5rlkq 297 5 addressed address VBN cord-302316-raf5rlkq 297 6 in in IN cord-302316-raf5rlkq 297 7 another another DT cord-302316-raf5rlkq 297 8 epicentre epicentre NN cord-302316-raf5rlkq 297 9 of of IN cord-302316-raf5rlkq 297 10 the the DT cord-302316-raf5rlkq 297 11 pandemic pandemic NN cord-302316-raf5rlkq 297 12 , , , cord-302316-raf5rlkq 297 13 in in IN cord-302316-raf5rlkq 297 14 Lombardy Lombardy NNP cord-302316-raf5rlkq 297 15 , , , cord-302316-raf5rlkq 297 16 with with IN cord-302316-raf5rlkq 297 17 a a DT cord-302316-raf5rlkq 297 18 large large JJ cord-302316-raf5rlkq 297 19 case case NN cord-302316-raf5rlkq 297 20 - - HYPH cord-302316-raf5rlkq 297 21 control control NN cord-302316-raf5rlkq 297 22 study study NN cord-302316-raf5rlkq 297 23 involving involve VBG cord-302316-raf5rlkq 297 24 6'272 6'272 CD cord-302316-raf5rlkq 297 25 COVID-19 covid-19 CD cord-302316-raf5rlkq 297 26 patients patient NNS cord-302316-raf5rlkq 297 27 and and CC cord-302316-raf5rlkq 297 28 30'000 30'000 CD cord-302316-raf5rlkq 297 29 controls control NNS cord-302316-raf5rlkq 297 30 , , , cord-302316-raf5rlkq 297 31 matched match VBN cord-302316-raf5rlkq 297 32 for for IN cord-302316-raf5rlkq 297 33 age age NN cord-302316-raf5rlkq 297 34 , , , cord-302316-raf5rlkq 297 35 sex sex NN cord-302316-raf5rlkq 297 36 and and CC cord-302316-raf5rlkq 297 37 municipality municipality NN cord-302316-raf5rlkq 297 38 . . . cord-302316-raf5rlkq 298 1 Angiotensin angiotensin NN cord-302316-raf5rlkq 298 2 II II NNP cord-302316-raf5rlkq 298 3 receptor receptor NN cord-302316-raf5rlkq 298 4 blockers blocker NNS cord-302316-raf5rlkq 298 5 ( ( -LRB- cord-302316-raf5rlkq 298 6 ARB ARB NNP cord-302316-raf5rlkq 298 7 ) ) -RRB- cord-302316-raf5rlkq 298 8 and and CC cord-302316-raf5rlkq 298 9 ACE ACE NNP cord-302316-raf5rlkq 298 10 inhibitors inhibitor NNS cord-302316-raf5rlkq 298 11 ( ( -LRB- cord-302316-raf5rlkq 298 12 ACEI ACEI NNP cord-302316-raf5rlkq 298 13 ) ) -RRB- cord-302316-raf5rlkq 298 14 , , , cord-302316-raf5rlkq 298 15 common common JJ cord-302316-raf5rlkq 298 16 antihypertensive antihypertensive JJ cord-302316-raf5rlkq 298 17 drugs drug NNS cord-302316-raf5rlkq 298 18 , , , cord-302316-raf5rlkq 298 19 were be VBD cord-302316-raf5rlkq 298 20 more more RBR cord-302316-raf5rlkq 298 21 frequently frequently RB cord-302316-raf5rlkq 298 22 used use VBN cord-302316-raf5rlkq 298 23 by by IN cord-302316-raf5rlkq 298 24 COVID-19 covid-19 JJ cord-302316-raf5rlkq 298 25 patients patient NNS cord-302316-raf5rlkq 298 26 than than IN cord-302316-raf5rlkq 298 27 in in IN cord-302316-raf5rlkq 298 28 the the DT cord-302316-raf5rlkq 298 29 control control NN cord-302316-raf5rlkq 298 30 group group NN cord-302316-raf5rlkq 298 31 ( ( -LRB- cord-302316-raf5rlkq 298 32 ARB ARB NNP cord-302316-raf5rlkq 298 33 : : : cord-302316-raf5rlkq 298 34 22 22 CD cord-302316-raf5rlkq 298 35 vs vs IN cord-302316-raf5rlkq 298 36 19 19 CD cord-302316-raf5rlkq 298 37 % % NN cord-302316-raf5rlkq 298 38 ; ; : cord-302316-raf5rlkq 298 39 ACEI ACEI NNP cord-302316-raf5rlkq 298 40 : : : cord-302316-raf5rlkq 298 41 24 24 CD cord-302316-raf5rlkq 298 42 vs. vs. CC cord-302316-raf5rlkq 298 43 21 21 CD cord-302316-raf5rlkq 298 44 % % NN cord-302316-raf5rlkq 298 45 ) ) -RRB- cord-302316-raf5rlkq 298 46 . . . cord-302316-raf5rlkq 299 1 After after IN cord-302316-raf5rlkq 299 2 multivariate multivariate JJ cord-302316-raf5rlkq 299 3 analysis analysis NN cord-302316-raf5rlkq 299 4 , , , cord-302316-raf5rlkq 299 5 neither neither CC cord-302316-raf5rlkq 299 6 ARB ARB NNP cord-302316-raf5rlkq 299 7 , , , cord-302316-raf5rlkq 299 8 ACEI ACEI NNP cord-302316-raf5rlkq 299 9 nor nor CC cord-302316-raf5rlkq 299 10 other other JJ cord-302316-raf5rlkq 299 11 common common JJ cord-302316-raf5rlkq 299 12 antihypertension antihypertension NN cord-302316-raf5rlkq 299 13 drugs drug NNS cord-302316-raf5rlkq 299 14 had have VBD cord-302316-raf5rlkq 299 15 a a DT cord-302316-raf5rlkq 299 16 significant significant JJ cord-302316-raf5rlkq 299 17 association association NN cord-302316-raf5rlkq 299 18 with with IN cord-302316-raf5rlkq 299 19 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 299 20 . . . cord-302316-raf5rlkq 300 1 The the DT cord-302316-raf5rlkq 300 2 Italian italian JJ cord-302316-raf5rlkq 300 3 study study NN cord-302316-raf5rlkq 300 4 confirmed confirm VBD cord-302316-raf5rlkq 300 5 the the DT cord-302316-raf5rlkq 300 6 Chinese chinese JJ cord-302316-raf5rlkq 300 7 observations observation NNS cord-302316-raf5rlkq 300 8 that that IN cord-302316-raf5rlkq 300 9 the the DT cord-302316-raf5rlkq 300 10 COVID-19 covid-19 CD cord-302316-raf5rlkq 300 11 patients patient NNS cord-302316-raf5rlkq 300 12 were be VBD cord-302316-raf5rlkq 300 13 in in IN cord-302316-raf5rlkq 300 14 poorer poor JJR cord-302316-raf5rlkq 300 15 health health NN cord-302316-raf5rlkq 300 16 than than IN cord-302316-raf5rlkq 300 17 the the DT cord-302316-raf5rlkq 300 18 general general JJ cord-302316-raf5rlkq 300 19 population population NN cord-302316-raf5rlkq 300 20 matched match VBN cord-302316-raf5rlkq 300 21 for for IN cord-302316-raf5rlkq 300 22 age age NN cord-302316-raf5rlkq 300 23 , , , cord-302316-raf5rlkq 300 24 particularly particularly RB cord-302316-raf5rlkq 300 25 with with IN cord-302316-raf5rlkq 300 26 respect respect NN cord-302316-raf5rlkq 300 27 to to IN cord-302316-raf5rlkq 300 28 previous previous JJ cord-302316-raf5rlkq 300 29 hospitalization hospitalization NN cord-302316-raf5rlkq 300 30 for for IN cord-302316-raf5rlkq 300 31 cardiovascular cardiovascular JJ cord-302316-raf5rlkq 300 32 diseases disease NNS cord-302316-raf5rlkq 300 33 ( ( -LRB- cord-302316-raf5rlkq 300 34 Mancia Mancia NNP cord-302316-raf5rlkq 300 35 et et NNP cord-302316-raf5rlkq 300 36 al al NNP cord-302316-raf5rlkq 300 37 . . NNP cord-302316-raf5rlkq 300 38 , , , cord-302316-raf5rlkq 300 39 2020 2020 CD cord-302316-raf5rlkq 300 40 ) ) -RRB- cord-302316-raf5rlkq 300 41 . . . cord-302316-raf5rlkq 301 1 These these DT cord-302316-raf5rlkq 301 2 conclusions conclusion NNS cord-302316-raf5rlkq 301 3 were be VBD cord-302316-raf5rlkq 301 4 corroborated corroborate VBN cord-302316-raf5rlkq 301 5 in in IN cord-302316-raf5rlkq 301 6 another another DT cord-302316-raf5rlkq 301 7 study study NN cord-302316-raf5rlkq 301 8 in in IN cord-302316-raf5rlkq 301 9 which which WDT cord-302316-raf5rlkq 301 10 8910 8910 CD cord-302316-raf5rlkq 301 11 hospitalized hospitalize VBD cord-302316-raf5rlkq 301 12 COVID-19 covid-19 CD cord-302316-raf5rlkq 301 13 patients patient NNS cord-302316-raf5rlkq 301 14 were be VBD cord-302316-raf5rlkq 301 15 compared compare VBN cord-302316-raf5rlkq 301 16 for for IN cord-302316-raf5rlkq 301 17 outcome outcome NN cord-302316-raf5rlkq 301 18 , , , cord-302316-raf5rlkq 301 19 namely namely RB cord-302316-raf5rlkq 301 20 death death NN cord-302316-raf5rlkq 301 21 ( ( -LRB- cord-302316-raf5rlkq 301 22 n n NN cord-302316-raf5rlkq 301 23 = = SYM cord-302316-raf5rlkq 301 24 515 515 CD cord-302316-raf5rlkq 301 25 ) ) -RRB- cord-302316-raf5rlkq 301 26 versus versus IN cord-302316-raf5rlkq 301 27 survival survival NN cord-302316-raf5rlkq 301 28 to to TO cord-302316-raf5rlkq 301 29 discharge discharge NN cord-302316-raf5rlkq 301 30 ( ( -LRB- cord-302316-raf5rlkq 301 31 n n NN cord-302316-raf5rlkq 301 32 = = SYM cord-302316-raf5rlkq 301 33 8395 8395 CD cord-302316-raf5rlkq 301 34 patients patient NNS cord-302316-raf5rlkq 301 35 ) ) -RRB- cord-302316-raf5rlkq 301 36 . . . cord-302316-raf5rlkq 302 1 The the DT cord-302316-raf5rlkq 302 2 cases case NNS cord-302316-raf5rlkq 302 3 were be VBD cord-302316-raf5rlkq 302 4 from from IN cord-302316-raf5rlkq 302 5 hospitals hospital NNS cord-302316-raf5rlkq 302 6 in in IN cord-302316-raf5rlkq 302 7 North North NNP cord-302316-raf5rlkq 302 8 America America NNP cord-302316-raf5rlkq 302 9 , , , cord-302316-raf5rlkq 302 10 Europe Europe NNP cord-302316-raf5rlkq 302 11 and and CC cord-302316-raf5rlkq 302 12 Asia Asia NNP cord-302316-raf5rlkq 302 13 . . . cord-302316-raf5rlkq 303 1 In in IN cord-302316-raf5rlkq 303 2 multivariate multivariate JJ cord-302316-raf5rlkq 303 3 analysis analysis NN cord-302316-raf5rlkq 303 4 : : : cord-302316-raf5rlkq 303 5 age age NN cord-302316-raf5rlkq 303 6 greater great JJR cord-302316-raf5rlkq 303 7 than than IN cord-302316-raf5rlkq 303 8 65 65 CD cord-302316-raf5rlkq 303 9 y y NN cord-302316-raf5rlkq 303 10 , , , cord-302316-raf5rlkq 303 11 coronary coronary JJ cord-302316-raf5rlkq 303 12 artery artery NN cord-302316-raf5rlkq 303 13 disease disease NN cord-302316-raf5rlkq 303 14 , , , cord-302316-raf5rlkq 303 15 congestive congestive JJ cord-302316-raf5rlkq 303 16 heart heart NN cord-302316-raf5rlkq 303 17 failure failure NN cord-302316-raf5rlkq 303 18 , , , cord-302316-raf5rlkq 303 19 cardiac cardiac JJ cord-302316-raf5rlkq 303 20 arrhythmia arrhythmia NN cord-302316-raf5rlkq 303 21 , , , cord-302316-raf5rlkq 303 22 chronic chronic JJ cord-302316-raf5rlkq 303 23 obstructive obstructive JJ cord-302316-raf5rlkq 303 24 pulmonary pulmonary JJ cord-302316-raf5rlkq 303 25 disease disease NN cord-302316-raf5rlkq 303 26 and and CC cord-302316-raf5rlkq 303 27 current current JJ cord-302316-raf5rlkq 303 28 smoking smoking NN cord-302316-raf5rlkq 303 29 were be VBD cord-302316-raf5rlkq 303 30 all all DT cord-302316-raf5rlkq 303 31 associated associate VBN cord-302316-raf5rlkq 303 32 with with IN cord-302316-raf5rlkq 303 33 a a DT cord-302316-raf5rlkq 303 34 higher high JJR cord-302316-raf5rlkq 303 35 risk risk NN cord-302316-raf5rlkq 303 36 of of IN cord-302316-raf5rlkq 303 37 in in IN cord-302316-raf5rlkq 303 38 - - HYPH cord-302316-raf5rlkq 303 39 hospital hospital NN cord-302316-raf5rlkq 303 40 death death NN cord-302316-raf5rlkq 303 41 . . . cord-302316-raf5rlkq 304 1 ACE ace NN cord-302316-raf5rlkq 304 2 inhibitor inhibitor NN cord-302316-raf5rlkq 304 3 use use NN cord-302316-raf5rlkq 304 4 was be VBD cord-302316-raf5rlkq 304 5 associated associate VBN cord-302316-raf5rlkq 304 6 with with IN cord-302316-raf5rlkq 304 7 a a DT cord-302316-raf5rlkq 304 8 significantly significantly RB cord-302316-raf5rlkq 304 9 lower low JJR cord-302316-raf5rlkq 304 10 risk risk NN cord-302316-raf5rlkq 304 11 of of IN cord-302316-raf5rlkq 304 12 death death NN cord-302316-raf5rlkq 304 13 , , , cord-302316-raf5rlkq 304 14 but but CC cord-302316-raf5rlkq 304 15 might may MD cord-302316-raf5rlkq 304 16 be be VB cord-302316-raf5rlkq 304 17 a a DT cord-302316-raf5rlkq 304 18 coincidental coincidental JJ cord-302316-raf5rlkq 304 19 observation observation NN cord-302316-raf5rlkq 304 20 for for IN cord-302316-raf5rlkq 304 21 multiple multiple JJ cord-302316-raf5rlkq 304 22 comparisons comparison NNS cord-302316-raf5rlkq 304 23 . . . cord-302316-raf5rlkq 305 1 However however RB cord-302316-raf5rlkq 305 2 , , , cord-302316-raf5rlkq 305 3 the the DT cord-302316-raf5rlkq 305 4 data datum NNS cord-302316-raf5rlkq 305 5 do do VBP cord-302316-raf5rlkq 305 6 not not RB cord-302316-raf5rlkq 305 7 provide provide VB cord-302316-raf5rlkq 305 8 evidence evidence NN cord-302316-raf5rlkq 305 9 for for IN cord-302316-raf5rlkq 305 10 a a DT cord-302316-raf5rlkq 305 11 detrimental detrimental JJ cord-302316-raf5rlkq 305 12 effect effect NN cord-302316-raf5rlkq 305 13 of of IN cord-302316-raf5rlkq 305 14 antihypertensive antihypertensive JJ cord-302316-raf5rlkq 305 15 drugs drug NNS cord-302316-raf5rlkq 305 16 on on IN cord-302316-raf5rlkq 305 17 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 305 18 mortality mortality NN cord-302316-raf5rlkq 305 19 ( ( -LRB- cord-302316-raf5rlkq 305 20 Mehra Mehra NNP cord-302316-raf5rlkq 305 21 et et NNP cord-302316-raf5rlkq 305 22 al al NNP cord-302316-raf5rlkq 305 23 . . NNP cord-302316-raf5rlkq 305 24 , , , cord-302316-raf5rlkq 305 25 2020 2020 CD cord-302316-raf5rlkq 305 26 ) ) -RRB- cord-302316-raf5rlkq 305 27 . . . cord-302316-raf5rlkq 305 28 _SP cord-302316-raf5rlkq 306 1 Until until IN cord-302316-raf5rlkq 306 2 now now RB cord-302316-raf5rlkq 306 3 no no DT cord-302316-raf5rlkq 306 4 prospective prospective NN cord-302316-raf5rlkq 306 5 , , , cord-302316-raf5rlkq 306 6 sufficiently sufficiently RB cord-302316-raf5rlkq 306 7 powered power VBN cord-302316-raf5rlkq 306 8 , , , cord-302316-raf5rlkq 306 9 controlled control VBN cord-302316-raf5rlkq 306 10 clinical clinical JJ cord-302316-raf5rlkq 306 11 trial trial NN cord-302316-raf5rlkq 306 12 that that WDT cord-302316-raf5rlkq 306 13 has have VBZ cord-302316-raf5rlkq 306 14 been be VBN cord-302316-raf5rlkq 306 15 reported report VBN cord-302316-raf5rlkq 306 16 in in IN cord-302316-raf5rlkq 306 17 a a DT cord-302316-raf5rlkq 306 18 peer peer NN cord-302316-raf5rlkq 306 19 - - HYPH cord-302316-raf5rlkq 306 20 reviewed review VBN cord-302316-raf5rlkq 306 21 publication publication NN cord-302316-raf5rlkq 306 22 has have VBZ cord-302316-raf5rlkq 306 23 reported report VBN cord-302316-raf5rlkq 306 24 an an DT cord-302316-raf5rlkq 306 25 impact impact NN cord-302316-raf5rlkq 306 26 of of IN cord-302316-raf5rlkq 306 27 drug drug NN cord-302316-raf5rlkq 306 28 interventions intervention NNS cord-302316-raf5rlkq 306 29 on on IN cord-302316-raf5rlkq 306 30 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 306 31 mortality mortality NN cord-302316-raf5rlkq 306 32 , , , cord-302316-raf5rlkq 306 33 despite despite IN cord-302316-raf5rlkq 306 34 more more JJR cord-302316-raf5rlkq 306 35 than than IN cord-302316-raf5rlkq 306 36 1'000 1'000 CD cord-302316-raf5rlkq 306 37 trials trial NNS cord-302316-raf5rlkq 306 38 registered register VBN cord-302316-raf5rlkq 306 39 on on IN cord-302316-raf5rlkq 306 40 ClinicalTrials.gov ClinicalTrials.gov NNP cord-302316-raf5rlkq 306 41 , , , cord-302316-raf5rlkq 306 42 including include VBG cord-302316-raf5rlkq 306 43 600 600 CD cord-302316-raf5rlkq 306 44 intervention intervention NN cord-302316-raf5rlkq 306 45 studies study NNS cord-302316-raf5rlkq 306 46 . . . cord-302316-raf5rlkq 307 1 Technical technical JJ cord-302316-raf5rlkq 307 2 problems problem NNS cord-302316-raf5rlkq 307 3 , , , cord-302316-raf5rlkq 307 4 such such JJ cord-302316-raf5rlkq 307 5 as as IN cord-302316-raf5rlkq 307 6 the the DT cord-302316-raf5rlkq 307 7 lack lack NN cord-302316-raf5rlkq 307 8 of of IN cord-302316-raf5rlkq 307 9 true true JJ cord-302316-raf5rlkq 307 10 control control NN cord-302316-raf5rlkq 307 11 groups group NNS cord-302316-raf5rlkq 307 12 , , , cord-302316-raf5rlkq 307 13 concomitant concomitant JJ cord-302316-raf5rlkq 307 14 other other JJ cord-302316-raf5rlkq 307 15 treatments treatment NNS cord-302316-raf5rlkq 307 16 , , , cord-302316-raf5rlkq 307 17 make make VB cord-302316-raf5rlkq 307 18 it -PRON- PRP cord-302316-raf5rlkq 307 19 difficult difficult JJ cord-302316-raf5rlkq 307 20 to to TO cord-302316-raf5rlkq 307 21 disentangle disentangle VB cord-302316-raf5rlkq 307 22 the the DT cord-302316-raf5rlkq 307 23 effects effect NNS cord-302316-raf5rlkq 307 24 . . . cord-302316-raf5rlkq 308 1 Many many JJ cord-302316-raf5rlkq 308 2 trials trial NNS cord-302316-raf5rlkq 308 3 were be VBD cord-302316-raf5rlkq 308 4 started start VBN cord-302316-raf5rlkq 308 5 before before IN cord-302316-raf5rlkq 308 6 the the DT cord-302316-raf5rlkq 308 7 insight insight NN cord-302316-raf5rlkq 308 8 into into IN cord-302316-raf5rlkq 308 9 COVID-19 covid-19 JJ cord-302316-raf5rlkq 308 10 pathogenesis pathogenesis NN cord-302316-raf5rlkq 308 11 , , , cord-302316-raf5rlkq 308 12 which which WDT cord-302316-raf5rlkq 308 13 are be VBP cord-302316-raf5rlkq 308 14 now now RB cord-302316-raf5rlkq 308 15 accumulating accumulate VBG cord-302316-raf5rlkq 308 16 , , , cord-302316-raf5rlkq 308 17 became become VBD cord-302316-raf5rlkq 308 18 available available JJ cord-302316-raf5rlkq 308 19 . . . cord-302316-raf5rlkq 309 1 Probably probably RB cord-302316-raf5rlkq 309 2 , , , cord-302316-raf5rlkq 309 3 reliable reliable JJ cord-302316-raf5rlkq 309 4 biomarkers biomarker NNS cord-302316-raf5rlkq 309 5 for for IN cord-302316-raf5rlkq 309 6 different different JJ cord-302316-raf5rlkq 309 7 pathological pathological JJ cord-302316-raf5rlkq 309 8 types type NNS cord-302316-raf5rlkq 309 9 of of IN cord-302316-raf5rlkq 309 10 COVID-19 covid-19 JJ cord-302316-raf5rlkq 309 11 forms form NNS cord-302316-raf5rlkq 309 12 are be VBP cord-302316-raf5rlkq 309 13 needed need VBN cord-302316-raf5rlkq 309 14 in in IN cord-302316-raf5rlkq 309 15 order order NN cord-302316-raf5rlkq 309 16 to to TO cord-302316-raf5rlkq 309 17 allow allow VB cord-302316-raf5rlkq 309 18 more more RBR cord-302316-raf5rlkq 309 19 precisely precisely RB cord-302316-raf5rlkq 309 20 targeted target VBN cord-302316-raf5rlkq 309 21 therapeutic therapeutic JJ cord-302316-raf5rlkq 309 22 interventions intervention NNS cord-302316-raf5rlkq 309 23 ( ( -LRB- cord-302316-raf5rlkq 309 24 Bauchner Bauchner NNP cord-302316-raf5rlkq 309 25 and and CC cord-302316-raf5rlkq 309 26 Fontanarosa Fontanarosa NNP cord-302316-raf5rlkq 309 27 , , , cord-302316-raf5rlkq 309 28 2020 2020 CD cord-302316-raf5rlkq 309 29 ) ) -RRB- cord-302316-raf5rlkq 309 30 . . . cord-302316-raf5rlkq 310 1 Many many JJ cord-302316-raf5rlkq 310 2 approaches approach NNS cord-302316-raf5rlkq 310 3 are be VBP cord-302316-raf5rlkq 310 4 with with IN cord-302316-raf5rlkq 310 5 repurposed repurpose VBN cord-302316-raf5rlkq 310 6 drugs drug NNS cord-302316-raf5rlkq 310 7 , , , cord-302316-raf5rlkq 310 8 developed develop VBN cord-302316-raf5rlkq 310 9 for for IN cord-302316-raf5rlkq 310 10 other other JJ cord-302316-raf5rlkq 310 11 infections infection NNS cord-302316-raf5rlkq 310 12 , , , cord-302316-raf5rlkq 310 13 in in IN cord-302316-raf5rlkq 310 14 order order NN cord-302316-raf5rlkq 310 15 to to TO cord-302316-raf5rlkq 310 16 cut cut VB cord-302316-raf5rlkq 310 17 down down RP cord-302316-raf5rlkq 310 18 the the DT cord-302316-raf5rlkq 310 19 time time NN cord-302316-raf5rlkq 310 20 needed need VBN cord-302316-raf5rlkq 310 21 for for IN cord-302316-raf5rlkq 310 22 drugs drug NNS cord-302316-raf5rlkq 310 23 to to TO cord-302316-raf5rlkq 310 24 reach reach VB cord-302316-raf5rlkq 310 25 patients patient NNS cord-302316-raf5rlkq 310 26 in in IN cord-302316-raf5rlkq 310 27 an an DT cord-302316-raf5rlkq 310 28 emergency emergency NN cord-302316-raf5rlkq 310 29 situation situation NN cord-302316-raf5rlkq 310 30 . . . cord-302316-raf5rlkq 311 1 These these DT cord-302316-raf5rlkq 311 2 approaches approach NNS cord-302316-raf5rlkq 311 3 need need VBP cord-302316-raf5rlkq 311 4 to to TO cord-302316-raf5rlkq 311 5 be be VB cord-302316-raf5rlkq 311 6 complemented complement VBN cord-302316-raf5rlkq 311 7 by by IN cord-302316-raf5rlkq 311 8 trials trial NNS cord-302316-raf5rlkq 311 9 specifically specifically RB cord-302316-raf5rlkq 311 10 tailored tailor VBN cord-302316-raf5rlkq 311 11 to to IN cord-302316-raf5rlkq 311 12 the the DT cord-302316-raf5rlkq 311 13 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 311 14 pathology pathology NN cord-302316-raf5rlkq 311 15 . . . cord-302316-raf5rlkq 312 1 A. A. NNP cord-302316-raf5rlkq 312 2 Fauci Fauci NNP cord-302316-raf5rlkq 312 3 reminded remind VBD cord-302316-raf5rlkq 312 4 us -PRON- PRP cord-302316-raf5rlkq 312 5 that that IN cord-302316-raf5rlkq 312 6 drug drug NN cord-302316-raf5rlkq 312 7 trials trial NNS cord-302316-raf5rlkq 312 8 of of IN cord-302316-raf5rlkq 312 9 HIV HIV NNP cord-302316-raf5rlkq 312 10 infections infection NNS cord-302316-raf5rlkq 312 11 progressed progress VBD cord-302316-raf5rlkq 312 12 in in IN cord-302316-raf5rlkq 312 13 small small JJ cord-302316-raf5rlkq 312 14 steps step NNS cord-302316-raf5rlkq 312 15 before before IN cord-302316-raf5rlkq 312 16 effective effective JJ cord-302316-raf5rlkq 312 17 drug drug NN cord-302316-raf5rlkq 312 18 combinations combination NNS cord-302316-raf5rlkq 312 19 could could MD cord-302316-raf5rlkq 312 20 be be VB cord-302316-raf5rlkq 312 21 developed develop VBN cord-302316-raf5rlkq 312 22 . . . cord-302316-raf5rlkq 313 1 The the DT cord-302316-raf5rlkq 313 2 pathogenicity pathogenicity NN cord-302316-raf5rlkq 313 3 of of IN cord-302316-raf5rlkq 313 4 SARS SARS NNP cord-302316-raf5rlkq 313 5 - - HYPH cord-302316-raf5rlkq 313 6 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 313 7 in in IN cord-302316-raf5rlkq 313 8 hACE2 hace2 NN cord-302316-raf5rlkq 313 9 transgenic transgenic JJ cord-302316-raf5rlkq 313 10 mice mouse NNS cord-302316-raf5rlkq 314 1 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 314 2 Autopsies Autopsies NNPS cord-302316-raf5rlkq 314 3 , , , cord-302316-raf5rlkq 314 4 Oklahoma Oklahoma NNP cord-302316-raf5rlkq 314 5 , , , cord-302316-raf5rlkq 314 6 USA USA NNP cord-302316-raf5rlkq 314 7 Randomized Randomized NNP cord-302316-raf5rlkq 314 8 clinical clinical JJ cord-302316-raf5rlkq 314 9 trials trial NNS cord-302316-raf5rlkq 314 10 and and CC cord-302316-raf5rlkq 314 11 COVID-19 covid-19 NN cord-302316-raf5rlkq 314 12 : : : cord-302316-raf5rlkq 314 13 managing managing NN cord-302316-raf5rlkq 314 14 expectations expectation NNS cord-302316-raf5rlkq 315 1 Imbalanced imbalanced JJ cord-302316-raf5rlkq 315 2 host host NN cord-302316-raf5rlkq 315 3 response response NN cord-302316-raf5rlkq 315 4 to to IN cord-302316-raf5rlkq 315 5 SARS SARS NNP cord-302316-raf5rlkq 315 6 - - HYPH cord-302316-raf5rlkq 315 7 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 315 8 drives drive VBZ cord-302316-raf5rlkq 315 9 development development NN cord-302316-raf5rlkq 315 10 of of IN cord-302316-raf5rlkq 315 11 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 315 12 Effect Effect NNP cord-302316-raf5rlkq 315 13 of of IN cord-302316-raf5rlkq 315 14 high high JJ cord-302316-raf5rlkq 315 15 vs vs IN cord-302316-raf5rlkq 315 16 low low JJ cord-302316-raf5rlkq 315 17 doses dose NNS cord-302316-raf5rlkq 315 18 of of IN cord-302316-raf5rlkq 315 19 chloroquine chloroquine NN cord-302316-raf5rlkq 315 20 diphosphate diphosphate NN cord-302316-raf5rlkq 315 21 as as IN cord-302316-raf5rlkq 315 22 adjunctive adjunctive JJ cord-302316-raf5rlkq 315 23 therapy therapy NN cord-302316-raf5rlkq 315 24 for for IN cord-302316-raf5rlkq 315 25 patients patient NNS cord-302316-raf5rlkq 315 26 hospitalized hospitalize VBN cord-302316-raf5rlkq 315 27 with with IN cord-302316-raf5rlkq 315 28 severe severe JJ cord-302316-raf5rlkq 315 29 acute acute JJ cord-302316-raf5rlkq 315 30 respiratory respiratory JJ cord-302316-raf5rlkq 315 31 syndrome syndrome NN cord-302316-raf5rlkq 315 32 coronavirus coronavirus NN cord-302316-raf5rlkq 315 33 2 2 CD cord-302316-raf5rlkq 316 1 ( ( -LRB- cord-302316-raf5rlkq 316 2 SARS SARS NNP cord-302316-raf5rlkq 316 3 - - HYPH cord-302316-raf5rlkq 316 4 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 316 5 ) ) -RRB- cord-302316-raf5rlkq 316 6 infection infection NN cord-302316-raf5rlkq 316 7 : : : cord-302316-raf5rlkq 316 8 a a DT cord-302316-raf5rlkq 316 9 randomized randomized JJ cord-302316-raf5rlkq 316 10 clinical clinical JJ cord-302316-raf5rlkq 316 11 trial trial NN cord-302316-raf5rlkq 316 12 Interleukin-1 Interleukin-1 NNP cord-302316-raf5rlkq 316 13 blockade blockade NN cord-302316-raf5rlkq 316 14 with with IN cord-302316-raf5rlkq 316 15 high high JJ cord-302316-raf5rlkq 316 16 - - HYPH cord-302316-raf5rlkq 316 17 dose dose NN cord-302316-raf5rlkq 316 18 anakinra anakinra NN cord-302316-raf5rlkq 316 19 in in IN cord-302316-raf5rlkq 316 20 patients patient NNS cord-302316-raf5rlkq 316 21 with with IN cord-302316-raf5rlkq 316 22 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 316 23 , , , cord-302316-raf5rlkq 316 24 acute acute JJ cord-302316-raf5rlkq 316 25 respiratory respiratory JJ cord-302316-raf5rlkq 316 26 distress distress NN cord-302316-raf5rlkq 316 27 syndrome syndrome NN cord-302316-raf5rlkq 316 28 , , , cord-302316-raf5rlkq 316 29 and and CC cord-302316-raf5rlkq 316 30 hyperinflammation hyperinflammation NN cord-302316-raf5rlkq 316 31 : : : cord-302316-raf5rlkq 317 1 a a DT cord-302316-raf5rlkq 317 2 retrospective retrospective JJ cord-302316-raf5rlkq 317 3 cohort cohort NN cord-302316-raf5rlkq 317 4 study study NN cord-302316-raf5rlkq 317 5 Simulation Simulation NNP cord-302316-raf5rlkq 317 6 of of IN cord-302316-raf5rlkq 317 7 the the DT cord-302316-raf5rlkq 317 8 clinical clinical JJ cord-302316-raf5rlkq 317 9 and and CC cord-302316-raf5rlkq 317 10 pathological pathological JJ cord-302316-raf5rlkq 317 11 manifestations manifestation NNS cord-302316-raf5rlkq 317 12 of of IN cord-302316-raf5rlkq 317 13 Coronavirus Coronavirus NNP cord-302316-raf5rlkq 317 14 Disease Disease NNP cord-302316-raf5rlkq 317 15 2019 2019 CD cord-302316-raf5rlkq 317 16 ( ( -LRB- cord-302316-raf5rlkq 317 17 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 317 18 ) ) -RRB- cord-302316-raf5rlkq 317 19 in in IN cord-302316-raf5rlkq 317 20 golden golden JJ cord-302316-raf5rlkq 317 21 Syrian syrian JJ cord-302316-raf5rlkq 317 22 hamster hamster NN cord-302316-raf5rlkq 317 23 model model NN cord-302316-raf5rlkq 317 24 : : : cord-302316-raf5rlkq 317 25 implications implication NNS cord-302316-raf5rlkq 317 26 for for IN cord-302316-raf5rlkq 317 27 disease disease NN cord-302316-raf5rlkq 317 28 pathogenesis pathogenesis NN cord-302316-raf5rlkq 317 29 and and CC cord-302316-raf5rlkq 317 30 transmissibility transmissibility NN cord-302316-raf5rlkq 317 31 Efficacy Efficacy NNP cord-302316-raf5rlkq 317 32 of of IN cord-302316-raf5rlkq 317 33 hydroxychloroquine hydroxychloroquine NN cord-302316-raf5rlkq 317 34 in in IN cord-302316-raf5rlkq 317 35 patients patient NNS cord-302316-raf5rlkq 317 36 with with IN cord-302316-raf5rlkq 317 37 COVID-19 covid-19 NN cord-302316-raf5rlkq 317 38 : : : cord-302316-raf5rlkq 317 39 results result NNS cord-302316-raf5rlkq 317 40 of of IN cord-302316-raf5rlkq 317 41 a a DT cord-302316-raf5rlkq 317 42 randomized randomized JJ cord-302316-raf5rlkq 317 43 clinical clinical JJ cord-302316-raf5rlkq 317 44 trial trial NN cord-302316-raf5rlkq 317 45 Detectable detectable JJ cord-302316-raf5rlkq 317 46 serum serum NN cord-302316-raf5rlkq 317 47 SARS SARS NNP cord-302316-raf5rlkq 317 48 - - HYPH cord-302316-raf5rlkq 317 49 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 317 50 viral viral JJ cord-302316-raf5rlkq 317 51 load load NN cord-302316-raf5rlkq 317 52 ( ( -LRB- cord-302316-raf5rlkq 317 53 RNAaemia RNAaemia NNP cord-302316-raf5rlkq 317 54 ) ) -RRB- cord-302316-raf5rlkq 317 55 is be VBZ cord-302316-raf5rlkq 317 56 closely closely RB cord-302316-raf5rlkq 317 57 correlated correlate VBN cord-302316-raf5rlkq 317 58 with with IN cord-302316-raf5rlkq 317 59 drastically drastically RB cord-302316-raf5rlkq 317 60 elevated elevate VBN cord-302316-raf5rlkq 317 61 interleukin interleukin NN cord-302316-raf5rlkq 317 62 6 6 CD cord-302316-raf5rlkq 317 63 ( ( -LRB- cord-302316-raf5rlkq 317 64 IL-6 IL-6 NNP cord-302316-raf5rlkq 317 65 ) ) -RRB- cord-302316-raf5rlkq 317 66 level level NN cord-302316-raf5rlkq 317 67 in in IN cord-302316-raf5rlkq 317 68 critically critically RB cord-302316-raf5rlkq 317 69 ill ill JJ cord-302316-raf5rlkq 317 70 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 317 71 patients patient NNS cord-302316-raf5rlkq 317 72 Comparative comparative JJ cord-302316-raf5rlkq 317 73 tropism tropism NN cord-302316-raf5rlkq 317 74 , , , cord-302316-raf5rlkq 317 75 replication replication NN cord-302316-raf5rlkq 317 76 kinetics kinetics NN cord-302316-raf5rlkq 317 77 , , , cord-302316-raf5rlkq 317 78 and and CC cord-302316-raf5rlkq 317 79 cell cell NN cord-302316-raf5rlkq 317 80 damage damage NN cord-302316-raf5rlkq 317 81 profiling profiling NN cord-302316-raf5rlkq 317 82 of of IN cord-302316-raf5rlkq 317 83 SARS SARS NNP cord-302316-raf5rlkq 317 84 - - HYPH cord-302316-raf5rlkq 317 85 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 317 86 and and CC cord-302316-raf5rlkq 317 87 SARS SARS NNP cord-302316-raf5rlkq 317 88 - - HYPH cord-302316-raf5rlkq 317 89 CoV CoV NNP cord-302316-raf5rlkq 317 90 with with IN cord-302316-raf5rlkq 317 91 implications implication NNS cord-302316-raf5rlkq 317 92 for for IN cord-302316-raf5rlkq 317 93 clinical clinical JJ cord-302316-raf5rlkq 317 94 manifestations manifestation NNS cord-302316-raf5rlkq 317 95 , , , cord-302316-raf5rlkq 317 96 transmissibility transmissibility NN cord-302316-raf5rlkq 317 97 , , , cord-302316-raf5rlkq 317 98 and and CC cord-302316-raf5rlkq 317 99 laboratory laboratory NN cord-302316-raf5rlkq 317 100 studies study NNS cord-302316-raf5rlkq 317 101 of of IN cord-302316-raf5rlkq 317 102 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 317 103 : : : cord-302316-raf5rlkq 317 104 an an DT cord-302316-raf5rlkq 317 105 observational observational JJ cord-302316-raf5rlkq 317 106 study study NN cord-302316-raf5rlkq 317 107 China China NNP cord-302316-raf5rlkq 317 108 is be VBZ cord-302316-raf5rlkq 317 109 promoting promote VBG cord-302316-raf5rlkq 317 110 coronavirus coronavirus NN cord-302316-raf5rlkq 317 111 treatments treatment NNS cord-302316-raf5rlkq 317 112 based base VBN cord-302316-raf5rlkq 317 113 on on IN cord-302316-raf5rlkq 317 114 unproven unproven JJ cord-302316-raf5rlkq 317 115 traditional traditional JJ cord-302316-raf5rlkq 317 116 medicines medicine NNS cord-302316-raf5rlkq 317 117 Arbidol Arbidol NNP cord-302316-raf5rlkq 317 118 combined combine VBN cord-302316-raf5rlkq 317 119 with with IN cord-302316-raf5rlkq 317 120 LPV LPV NNP cord-302316-raf5rlkq 317 121 / / SYM cord-302316-raf5rlkq 317 122 r r NN cord-302316-raf5rlkq 317 123 versus versus IN cord-302316-raf5rlkq 317 124 LPV LPV NNP cord-302316-raf5rlkq 317 125 / / SYM cord-302316-raf5rlkq 317 126 r r NN cord-302316-raf5rlkq 317 127 alone alone RB cord-302316-raf5rlkq 317 128 against against IN cord-302316-raf5rlkq 317 129 corona corona NN cord-302316-raf5rlkq 317 130 virus virus NN cord-302316-raf5rlkq 317 131 disease disease NNP cord-302316-raf5rlkq 317 132 2019 2019 CD cord-302316-raf5rlkq 317 133 : : : cord-302316-raf5rlkq 318 1 a a DT cord-302316-raf5rlkq 318 2 retrospective retrospective JJ cord-302316-raf5rlkq 318 3 cohort cohort NN cord-302316-raf5rlkq 318 4 study study NN cord-302316-raf5rlkq 318 5 Development Development NNP cord-302316-raf5rlkq 318 6 of of IN cord-302316-raf5rlkq 318 7 an an DT cord-302316-raf5rlkq 318 8 inactivated inactivated JJ cord-302316-raf5rlkq 318 9 vaccine vaccine NN cord-302316-raf5rlkq 318 10 candidate candidate NN cord-302316-raf5rlkq 318 11 for for IN cord-302316-raf5rlkq 318 12 SARS SARS NNP cord-302316-raf5rlkq 318 13 - - HYPH cord-302316-raf5rlkq 318 14 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 318 15 Observational observational JJ cord-302316-raf5rlkq 318 16 study study NN cord-302316-raf5rlkq 318 17 of of IN cord-302316-raf5rlkq 318 18 hydroxychloroquine hydroxychloroquine NNP cord-302316-raf5rlkq 318 19 in in IN cord-302316-raf5rlkq 318 20 hospitalized hospitalize VBN cord-302316-raf5rlkq 318 21 patients patient NNS cord-302316-raf5rlkq 318 22 with with IN cord-302316-raf5rlkq 318 23 Covid-19 Covid-19 NNP cord-302316-raf5rlkq 318 24 Complex Complex NNP cord-302316-raf5rlkq 318 25 immune immune JJ cord-302316-raf5rlkq 318 26 dysregulation dysregulation NN cord-302316-raf5rlkq 318 27 in in IN cord-302316-raf5rlkq 318 28 COVID-19 covid-19 JJ cord-302316-raf5rlkq 318 29 patients patient NNS cord-302316-raf5rlkq 318 30 with with IN cord-302316-raf5rlkq 318 31 severe severe JJ cord-302316-raf5rlkq 318 32 respiratory respiratory JJ cord-302316-raf5rlkq 318 33 failure failure NN cord-302316-raf5rlkq 319 1 A a DT cord-302316-raf5rlkq 319 2 SARS SARS NNP cord-302316-raf5rlkq 319 3 - - HYPH cord-302316-raf5rlkq 319 4 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 319 5 protein protein NN cord-302316-raf5rlkq 319 6 interaction interaction NN cord-302316-raf5rlkq 319 7 map map NN cord-302316-raf5rlkq 319 8 reveals reveal VBZ cord-302316-raf5rlkq 319 9 targets target NNS cord-302316-raf5rlkq 319 10 for for IN cord-302316-raf5rlkq 319 11 drug drug NN cord-302316-raf5rlkq 319 12 repurposing repurpose VBG cord-302316-raf5rlkq 319 13 Compassionate compassionate JJ cord-302316-raf5rlkq 319 14 use use NN cord-302316-raf5rlkq 319 15 of of IN cord-302316-raf5rlkq 319 16 remdesivir remdesivir NNS cord-302316-raf5rlkq 319 17 for for IN cord-302316-raf5rlkq 319 18 patients patient NNS cord-302316-raf5rlkq 319 19 with with IN cord-302316-raf5rlkq 319 20 severe severe JJ cord-302316-raf5rlkq 319 21 Covid-19 covid-19 NN cord-302316-raf5rlkq 319 22 ª ª NN cord-302316-raf5rlkq 319 23 2020 2020 CD cord-302316-raf5rlkq 320 1 The the DT cord-302316-raf5rlkq 320 2 Authors author NNS cord-302316-raf5rlkq 320 3 . . . cord-302316-raf5rlkq 321 1 Microbial Microbial NNP cord-302316-raf5rlkq 321 2 Biotechnology Biotechnology NNP cord-302316-raf5rlkq 321 3 published publish VBN cord-302316-raf5rlkq 321 4 by by IN cord-302316-raf5rlkq 321 5 John John NNP cord-302316-raf5rlkq 321 6 Wiley Wiley NNP cord-302316-raf5rlkq 321 7 & & CC cord-302316-raf5rlkq 321 8 Sons Sons NNPS cord-302316-raf5rlkq 321 9 Ltd Ltd NNP cord-302316-raf5rlkq 321 10 and and CC cord-302316-raf5rlkq 321 11 Society Society NNP cord-302316-raf5rlkq 321 12 for for IN cord-302316-raf5rlkq 321 13 Applied Applied NNP cord-302316-raf5rlkq 321 14 Microbiology Microbiology NNP cord-302316-raf5rlkq 321 15 . . . cord-302316-raf5rlkq 322 1 Covid-19 Covid-19 NNP cord-302316-raf5rlkq 322 2 : : : cord-302316-raf5rlkq 322 3 Pathogenesis pathogenesis NN cord-302316-raf5rlkq 322 4 and and CC cord-302316-raf5rlkq 322 5 drugs drug NNS cord-302316-raf5rlkq 322 6 9 9 CD cord-302316-raf5rlkq 322 7 COVID-19 covid-19 VBP cord-302316-raf5rlkq 322 8 : : : cord-302316-raf5rlkq 322 9 A a DT cord-302316-raf5rlkq 322 10 New New NNP cord-302316-raf5rlkq 322 11 Virus virus NN cord-302316-raf5rlkq 322 12 , , , cord-302316-raf5rlkq 322 13 but but CC cord-302316-raf5rlkq 322 14 a a DT cord-302316-raf5rlkq 322 15 Familiar familiar JJ cord-302316-raf5rlkq 322 16 Receptor receptor NN cord-302316-raf5rlkq 322 17 and and CC cord-302316-raf5rlkq 322 18 Cytokine Cytokine NNP cord-302316-raf5rlkq 322 19 Release Release NNP cord-302316-raf5rlkq 322 20 Syndrome Syndrome NNP cord-302316-raf5rlkq 322 21 SARS SARS NNP cord-302316-raf5rlkq 322 22 - - HYPH cord-302316-raf5rlkq 322 23 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 322 24 cell cell NN cord-302316-raf5rlkq 322 25 entry entry NN cord-302316-raf5rlkq 322 26 depends depend VBZ cord-302316-raf5rlkq 322 27 on on IN cord-302316-raf5rlkq 322 28 ACE2 ACE2 NNP cord-302316-raf5rlkq 322 29 and and CC cord-302316-raf5rlkq 322 30 TMPRSS2 TMPRSS2 NNP cord-302316-raf5rlkq 322 31 and and CC cord-302316-raf5rlkq 322 32 is be VBZ cord-302316-raf5rlkq 322 33 blocked block VBN cord-302316-raf5rlkq 322 34 by by IN cord-302316-raf5rlkq 322 35 a a DT cord-302316-raf5rlkq 322 36 clinically clinically RB cord-302316-raf5rlkq 322 37 proven prove VBN cord-302316-raf5rlkq 322 38 protease protease NN cord-302316-raf5rlkq 322 39 inhibitor inhibitor NN cord-302316-raf5rlkq 322 40 Tropism tropism NN cord-302316-raf5rlkq 322 41 , , , cord-302316-raf5rlkq 322 42 replication replication NN cord-302316-raf5rlkq 322 43 competence competence NN cord-302316-raf5rlkq 322 44 , , , cord-302316-raf5rlkq 322 45 and and CC cord-302316-raf5rlkq 322 46 innate innate JJ cord-302316-raf5rlkq 322 47 immune immune JJ cord-302316-raf5rlkq 322 48 responses response NNS cord-302316-raf5rlkq 322 49 of of IN cord-302316-raf5rlkq 322 50 the the DT cord-302316-raf5rlkq 322 51 coronavirus coronavirus NN cord-302316-raf5rlkq 322 52 SARS SARS NNP cord-302316-raf5rlkq 322 53 - - HYPH cord-302316-raf5rlkq 322 54 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 322 55 in in IN cord-302316-raf5rlkq 322 56 human human JJ cord-302316-raf5rlkq 322 57 respiratory respiratory JJ cord-302316-raf5rlkq 322 58 tract tract NN cord-302316-raf5rlkq 322 59 and and CC cord-302316-raf5rlkq 322 60 conjunctiva conjunctiva NN cord-302316-raf5rlkq 322 61 : : : cord-302316-raf5rlkq 322 62 an an DT cord-302316-raf5rlkq 322 63 analysis analysis NN cord-302316-raf5rlkq 322 64 in in IN cord-302316-raf5rlkq 322 65 ex ex JJ cord-302316-raf5rlkq 322 66 - - NN cord-302316-raf5rlkq 322 67 vivo vivo JJ cord-302316-raf5rlkq 322 68 and and CC cord-302316-raf5rlkq 322 69 in in IN cord-302316-raf5rlkq 322 70 - - HYPH cord-302316-raf5rlkq 322 71 vitro vitro FW cord-302316-raf5rlkq 322 72 cultures culture NNS cord-302316-raf5rlkq 322 73 Epub epub RB cord-302316-raf5rlkq 322 74 ahead ahead RB cord-302316-raf5rlkq 322 75 of of IN cord-302316-raf5rlkq 322 76 print print NN cord-302316-raf5rlkq 322 77 Triple triple JJ cord-302316-raf5rlkq 322 78 combination combination NN cord-302316-raf5rlkq 322 79 of of IN cord-302316-raf5rlkq 322 80 interferon interferon NN cord-302316-raf5rlkq 322 81 beta-1b beta-1b NNP cord-302316-raf5rlkq 322 82 , , , cord-302316-raf5rlkq 322 83 lopinavir lopinavir NNS cord-302316-raf5rlkq 322 84 - - HYPH cord-302316-raf5rlkq 322 85 ritonavir ritonavir NNS cord-302316-raf5rlkq 322 86 , , , cord-302316-raf5rlkq 322 87 and and CC cord-302316-raf5rlkq 322 88 ribavirin ribavirin NN cord-302316-raf5rlkq 322 89 in in IN cord-302316-raf5rlkq 322 90 the the DT cord-302316-raf5rlkq 322 91 treatment treatment NN cord-302316-raf5rlkq 322 92 of of IN cord-302316-raf5rlkq 322 93 patients patient NNS cord-302316-raf5rlkq 322 94 admitted admit VBN cord-302316-raf5rlkq 322 95 to to IN cord-302316-raf5rlkq 322 96 hospital hospital NN cord-302316-raf5rlkq 322 97 with with IN cord-302316-raf5rlkq 322 98 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 322 99 : : : cord-302316-raf5rlkq 322 100 an an DT cord-302316-raf5rlkq 322 101 open open JJ cord-302316-raf5rlkq 322 102 - - HYPH cord-302316-raf5rlkq 322 103 label label NN cord-302316-raf5rlkq 322 104 , , , cord-302316-raf5rlkq 322 105 randomised randomised JJ cord-302316-raf5rlkq 322 106 , , , cord-302316-raf5rlkq 322 107 phase phase NN cord-302316-raf5rlkq 322 108 2 2 CD cord-302316-raf5rlkq 322 109 trial trial NN cord-302316-raf5rlkq 322 110 Structure Structure NNP cord-302316-raf5rlkq 322 111 of of IN cord-302316-raf5rlkq 322 112 M(pro M(pro NNP cord-302316-raf5rlkq 322 113 ) ) -RRB- cord-302316-raf5rlkq 322 114 from from IN cord-302316-raf5rlkq 322 115 SARS SARS NNP cord-302316-raf5rlkq 322 116 - - HYPH cord-302316-raf5rlkq 322 117 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 322 118 and and CC cord-302316-raf5rlkq 322 119 discovery discovery NN cord-302316-raf5rlkq 322 120 of of IN cord-302316-raf5rlkq 322 121 its -PRON- PRP$ cord-302316-raf5rlkq 322 122 inhibitors inhibitor NNS cord-302316-raf5rlkq 322 123 Infection infection NN cord-302316-raf5rlkq 322 124 and and CC cord-302316-raf5rlkq 322 125 rapid rapid JJ cord-302316-raf5rlkq 322 126 transmission transmission NN cord-302316-raf5rlkq 322 127 of of IN cord-302316-raf5rlkq 322 128 SARS SARS NNP cord-302316-raf5rlkq 322 129 - - HYPH cord-302316-raf5rlkq 322 130 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 322 131 in in IN cord-302316-raf5rlkq 322 132 ferrets ferret NNS cord-302316-raf5rlkq 322 133 SARS SARS NNP cord-302316-raf5rlkq 322 134 - - : cord-302316-raf5rlkq 322 135 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 322 136 productively productively RB cord-302316-raf5rlkq 322 137 infects infect VBZ cord-302316-raf5rlkq 322 138 human human JJ cord-302316-raf5rlkq 322 139 gut gut NN cord-302316-raf5rlkq 322 140 enterocytes enterocyte NNS cord-302316-raf5rlkq 323 1 Hopes hope NNS cord-302316-raf5rlkq 323 2 rise rise VBP cord-302316-raf5rlkq 323 3 for for IN cord-302316-raf5rlkq 323 4 coronavirus coronavirus NN cord-302316-raf5rlkq 323 5 drug drug NN cord-302316-raf5rlkq 323 6 remdesivir remdesivir NNP cord-302316-raf5rlkq 323 7 Epub Epub NNP cord-302316-raf5rlkq 323 8 ahead ahead RB cord-302316-raf5rlkq 323 9 of of IN cord-302316-raf5rlkq 323 10 print print NN cord-302316-raf5rlkq 323 11 SARS SARS NNP cord-302316-raf5rlkq 323 12 - - HYPH cord-302316-raf5rlkq 323 13 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 323 14 and and CC cord-302316-raf5rlkq 323 15 viral viral JJ cord-302316-raf5rlkq 323 16 sepsis sepsis NN cord-302316-raf5rlkq 323 17 : : : cord-302316-raf5rlkq 324 1 observations observation NNS cord-302316-raf5rlkq 324 2 and and CC cord-302316-raf5rlkq 324 3 hypotheses hypothesis NNS cord-302316-raf5rlkq 324 4 Efficacy Efficacy NNP cord-302316-raf5rlkq 324 5 and and CC cord-302316-raf5rlkq 324 6 safety safety NN cord-302316-raf5rlkq 324 7 of of IN cord-302316-raf5rlkq 324 8 lopinavir lopinavir NNP cord-302316-raf5rlkq 324 9 / / SYM cord-302316-raf5rlkq 324 10 ritonavir ritonavir NNP cord-302316-raf5rlkq 324 11 or or CC cord-302316-raf5rlkq 324 12 arbidol arbidol NN cord-302316-raf5rlkq 324 13 in in IN cord-302316-raf5rlkq 324 14 adult adult NN cord-302316-raf5rlkq 324 15 patients patient NNS cord-302316-raf5rlkq 324 16 with with IN cord-302316-raf5rlkq 324 17 mild mild JJ cord-302316-raf5rlkq 324 18 / / SYM cord-302316-raf5rlkq 324 19 moderate moderate JJ cord-302316-raf5rlkq 324 20 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 324 21 : : : cord-302316-raf5rlkq 324 22 an an DT cord-302316-raf5rlkq 324 23 exploratory exploratory NN cord-302316-raf5rlkq 324 24 randomized randomize VBN cord-302316-raf5rlkq 324 25 controlled control VBN cord-302316-raf5rlkq 324 26 trial trial NN cord-302316-raf5rlkq 324 27 No no DT cord-302316-raf5rlkq 324 28 evidence evidence NN cord-302316-raf5rlkq 324 29 of of IN cord-302316-raf5rlkq 324 30 clinical clinical JJ cord-302316-raf5rlkq 324 31 efficacy efficacy NN cord-302316-raf5rlkq 324 32 of of IN cord-302316-raf5rlkq 324 33 hydroxychloroquine hydroxychloroquine NN cord-302316-raf5rlkq 324 34 in in IN cord-302316-raf5rlkq 324 35 patients patient NNS cord-302316-raf5rlkq 324 36 hospitalised hospitalise VBN cord-302316-raf5rlkq 324 37 for for IN cord-302316-raf5rlkq 324 38 COVID-19 covid-19 JJ cord-302316-raf5rlkq 324 39 infection infection NN cord-302316-raf5rlkq 324 40 and and CC cord-302316-raf5rlkq 324 41 requiring require VBG cord-302316-raf5rlkq 324 42 oxygen oxygen NN cord-302316-raf5rlkq 324 43 : : : cord-302316-raf5rlkq 324 44 results result NNS cord-302316-raf5rlkq 324 45 of of IN cord-302316-raf5rlkq 324 46 a a DT cord-302316-raf5rlkq 324 47 study study NN cord-302316-raf5rlkq 324 48 using use VBG cord-302316-raf5rlkq 324 49 routinely routinely RB cord-302316-raf5rlkq 324 50 collected collect VBN cord-302316-raf5rlkq 324 51 data datum NNS cord-302316-raf5rlkq 324 52 to to TO cord-302316-raf5rlkq 324 53 emulate emulate VB cord-302316-raf5rlkq 324 54 a a DT cord-302316-raf5rlkq 324 55 target target NN cord-302316-raf5rlkq 324 56 trial trial NN cord-302316-raf5rlkq 324 57 Renin renin NN cord-302316-raf5rlkq 324 58 - - HYPH cord-302316-raf5rlkq 324 59 angiotensin angiotensin NN cord-302316-raf5rlkq 324 60 - - HYPH cord-302316-raf5rlkq 324 61 aldosterone aldosterone NN cord-302316-raf5rlkq 324 62 system system NN cord-302316-raf5rlkq 324 63 blockers blocker NNS cord-302316-raf5rlkq 324 64 and and CC cord-302316-raf5rlkq 324 65 the the DT cord-302316-raf5rlkq 324 66 risk risk NN cord-302316-raf5rlkq 324 67 of of IN cord-302316-raf5rlkq 324 68 Covid-19 Covid-19 NNP cord-302316-raf5rlkq 324 69 Immune Immune NNP cord-302316-raf5rlkq 324 70 mechanisms mechanism NNS cord-302316-raf5rlkq 324 71 of of IN cord-302316-raf5rlkq 324 72 pulmonary pulmonary JJ cord-302316-raf5rlkq 324 73 intravascular intravascular JJ cord-302316-raf5rlkq 324 74 coagulopathy coagulopathy NN cord-302316-raf5rlkq 324 75 in in IN cord-302316-raf5rlkq 324 76 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 324 77 pneumonia pneumonia NN cord-302316-raf5rlkq 324 78 Cardiovascular Cardiovascular NNP cord-302316-raf5rlkq 324 79 disease disease NN cord-302316-raf5rlkq 324 80 , , , cord-302316-raf5rlkq 324 81 drug drug NN cord-302316-raf5rlkq 324 82 therapy therapy NN cord-302316-raf5rlkq 324 83 , , , cord-302316-raf5rlkq 324 84 and and CC cord-302316-raf5rlkq 324 85 mortality mortality NN cord-302316-raf5rlkq 324 86 in in IN cord-302316-raf5rlkq 324 87 Covid-19 covid-19 NN cord-302316-raf5rlkq 324 88 Silencing silence VBG cord-302316-raf5rlkq 324 89 the the DT cord-302316-raf5rlkq 324 90 cytokine cytokine NN cord-302316-raf5rlkq 324 91 storm storm NN cord-302316-raf5rlkq 324 92 : : : cord-302316-raf5rlkq 324 93 the the DT cord-302316-raf5rlkq 324 94 use use NN cord-302316-raf5rlkq 324 95 of of IN cord-302316-raf5rlkq 324 96 intravenous intravenous JJ cord-302316-raf5rlkq 324 97 anakinra anakinra NN cord-302316-raf5rlkq 324 98 in in IN cord-302316-raf5rlkq 324 99 haemophagocytic haemophagocytic NNP cord-302316-raf5rlkq 324 100 lymphohistiocytosis lymphohistiocytosis NNP cord-302316-raf5rlkq 324 101 or or CC cord-302316-raf5rlkq 324 102 macrophage macrophage NN cord-302316-raf5rlkq 324 103 activation activation NN cord-302316-raf5rlkq 324 104 syndrome syndrome NN cord-302316-raf5rlkq 325 1 A a DT cord-302316-raf5rlkq 325 2 dynamic dynamic JJ cord-302316-raf5rlkq 325 3 immune immune JJ cord-302316-raf5rlkq 325 4 response response NN cord-302316-raf5rlkq 325 5 shapes shape NNS cord-302316-raf5rlkq 326 1 COVID-19 covid-19 JJ cord-302316-raf5rlkq 326 2 progression progression NN cord-302316-raf5rlkq 326 3 Renin renin NN cord-302316-raf5rlkq 326 4 - - HYPH cord-302316-raf5rlkq 326 5 angiotensin angiotensin NN cord-302316-raf5rlkq 326 6 - - HYPH cord-302316-raf5rlkq 326 7 aldosterone aldosterone NN cord-302316-raf5rlkq 326 8 system system NN cord-302316-raf5rlkq 326 9 inhibitors inhibitor NNS cord-302316-raf5rlkq 326 10 and and CC cord-302316-raf5rlkq 326 11 risk risk NN cord-302316-raf5rlkq 326 12 of of IN cord-302316-raf5rlkq 326 13 Covid-19 Covid-19 NNP cord-302316-raf5rlkq 326 14 Comparative Comparative NNP cord-302316-raf5rlkq 326 15 pathogenesis pathogenesis NN cord-302316-raf5rlkq 326 16 of of IN cord-302316-raf5rlkq 326 17 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 326 18 , , , cord-302316-raf5rlkq 326 19 MERS MERS NNP cord-302316-raf5rlkq 326 20 , , , cord-302316-raf5rlkq 326 21 and and CC cord-302316-raf5rlkq 326 22 SARS SARS NNP cord-302316-raf5rlkq 326 23 in in IN cord-302316-raf5rlkq 326 24 a a DT cord-302316-raf5rlkq 326 25 nonhuman nonhuman NN cord-302316-raf5rlkq 326 26 primate primate NN cord-302316-raf5rlkq 326 27 model model NN cord-302316-raf5rlkq 326 28 Type type NN cord-302316-raf5rlkq 326 29 2 2 CD cord-302316-raf5rlkq 326 30 and and CC cord-302316-raf5rlkq 326 31 interferon interferon NN cord-302316-raf5rlkq 326 32 inflammation inflammation NN cord-302316-raf5rlkq 326 33 strongly strongly RB cord-302316-raf5rlkq 326 34 regulate regulate VBP cord-302316-raf5rlkq 326 35 SARS SARS NNP cord-302316-raf5rlkq 326 36 - - HYPH cord-302316-raf5rlkq 326 37 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 326 38 related related JJ cord-302316-raf5rlkq 326 39 gene gene NN cord-302316-raf5rlkq 326 40 expression expression NN cord-302316-raf5rlkq 326 41 in in IN cord-302316-raf5rlkq 326 42 the the DT cord-302316-raf5rlkq 326 43 airway airway NN cord-302316-raf5rlkq 326 44 epithelium epithelium NN cord-302316-raf5rlkq 327 1 An an DT cord-302316-raf5rlkq 327 2 orally orally RB cord-302316-raf5rlkq 327 3 bioavailable bioavailable JJ cord-302316-raf5rlkq 327 4 broad broad JJ cord-302316-raf5rlkq 327 5 - - HYPH cord-302316-raf5rlkq 327 6 spectrum spectrum NN cord-302316-raf5rlkq 327 7 antiviral antiviral JJ cord-302316-raf5rlkq 327 8 inhibits inhibit VBZ cord-302316-raf5rlkq 327 9 SARS SARS NNP cord-302316-raf5rlkq 327 10 - - HYPH cord-302316-raf5rlkq 327 11 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 327 12 in in IN cord-302316-raf5rlkq 327 13 human human JJ cord-302316-raf5rlkq 327 14 airway airway NN cord-302316-raf5rlkq 327 15 epithelial epithelial JJ cord-302316-raf5rlkq 327 16 cell cell NN cord-302316-raf5rlkq 327 17 cultures culture NNS cord-302316-raf5rlkq 327 18 and and CC cord-302316-raf5rlkq 327 19 multiple multiple JJ cord-302316-raf5rlkq 327 20 coronaviruses coronaviruse NNS cord-302316-raf5rlkq 327 21 in in IN cord-302316-raf5rlkq 327 22 mice mouse NNS cord-302316-raf5rlkq 327 23 Susceptibility susceptibility NN cord-302316-raf5rlkq 327 24 of of IN cord-302316-raf5rlkq 327 25 ferrets ferret NNS cord-302316-raf5rlkq 327 26 , , , cord-302316-raf5rlkq 327 27 cats cat NNS cord-302316-raf5rlkq 327 28 , , , cord-302316-raf5rlkq 327 29 dogs dog NNS cord-302316-raf5rlkq 327 30 , , , cord-302316-raf5rlkq 327 31 and and CC cord-302316-raf5rlkq 327 32 other other JJ cord-302316-raf5rlkq 327 33 domesticated domesticated JJ cord-302316-raf5rlkq 327 34 animals animal NNS cord-302316-raf5rlkq 327 35 to to IN cord-302316-raf5rlkq 327 36 SARS SARS NNP cord-302316-raf5rlkq 327 37 - - HYPH cord-302316-raf5rlkq 327 38 coronavirus coronavirus NN cord-302316-raf5rlkq 327 39 2 2 CD cord-302316-raf5rlkq 327 40 Anticoagulant anticoagulant JJ cord-302316-raf5rlkq 327 41 treatment treatment NN cord-302316-raf5rlkq 327 42 is be VBZ cord-302316-raf5rlkq 327 43 associated associate VBN cord-302316-raf5rlkq 327 44 with with IN cord-302316-raf5rlkq 327 45 decreased decrease VBN cord-302316-raf5rlkq 327 46 mortality mortality NN cord-302316-raf5rlkq 327 47 in in IN cord-302316-raf5rlkq 327 48 severe severe JJ cord-302316-raf5rlkq 327 49 coronavirus coronavirus NN cord-302316-raf5rlkq 327 50 disease disease NN cord-302316-raf5rlkq 327 51 2019 2019 CD cord-302316-raf5rlkq 327 52 patients patient NNS cord-302316-raf5rlkq 327 53 with with IN cord-302316-raf5rlkq 327 54 coagulopathy coagulopathy NN cord-302316-raf5rlkq 327 55 Hydroxychloroquine Hydroxychloroquine NNP cord-302316-raf5rlkq 327 56 in in IN cord-302316-raf5rlkq 327 57 patients patient NNS cord-302316-raf5rlkq 327 58 with with IN cord-302316-raf5rlkq 327 59 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 327 60 : : : cord-302316-raf5rlkq 327 61 an an DT cord-302316-raf5rlkq 327 62 open open JJ cord-302316-raf5rlkq 327 63 - - HYPH cord-302316-raf5rlkq 327 64 label label NN cord-302316-raf5rlkq 327 65 , , , cord-302316-raf5rlkq 327 66 randomized randomized JJ cord-302316-raf5rlkq 327 67 , , , cord-302316-raf5rlkq 327 68 controlled control VBN cord-302316-raf5rlkq 327 69 trial trial NN cord-302316-raf5rlkq 327 70 Remdesivir Remdesivir NNP cord-302316-raf5rlkq 327 71 in in IN cord-302316-raf5rlkq 327 72 adults adult NNS cord-302316-raf5rlkq 327 73 with with IN cord-302316-raf5rlkq 327 74 severe severe JJ cord-302316-raf5rlkq 327 75 COVID-19 covid-19 NN cord-302316-raf5rlkq 327 76 : : : cord-302316-raf5rlkq 327 77 a a DT cord-302316-raf5rlkq 327 78 randomised randomised JJ cord-302316-raf5rlkq 327 79 , , , cord-302316-raf5rlkq 327 80 double double JJ cord-302316-raf5rlkq 327 81 - - HYPH cord-302316-raf5rlkq 327 82 blind blind JJ cord-302316-raf5rlkq 327 83 , , , cord-302316-raf5rlkq 327 84 placebo placebo NN cord-302316-raf5rlkq 327 85 - - HYPH cord-302316-raf5rlkq 327 86 controlled control VBN cord-302316-raf5rlkq 327 87 , , , cord-302316-raf5rlkq 327 88 multicentre multicentre NNP cord-302316-raf5rlkq 327 89 trial trial NN cord-302316-raf5rlkq 327 90 Autopsy Autopsy NNP cord-302316-raf5rlkq 327 91 Findings Findings NNP cord-302316-raf5rlkq 327 92 and and CC cord-302316-raf5rlkq 327 93 Venous Venous NNP cord-302316-raf5rlkq 327 94 Thromboembolism Thromboembolism NNP cord-302316-raf5rlkq 327 95 in in IN cord-302316-raf5rlkq 327 96 Patients patient NNS cord-302316-raf5rlkq 327 97 With with IN cord-302316-raf5rlkq 327 98 COVIDª COVIDª NNS cord-302316-raf5rlkq 327 99 2020 2020 CD cord-302316-raf5rlkq 328 1 The the DT cord-302316-raf5rlkq 328 2 Authors Authors NNPS cord-302316-raf5rlkq 328 3 Isolation Isolation NNP cord-302316-raf5rlkq 328 4 of of IN cord-302316-raf5rlkq 328 5 SARS SARS NNP cord-302316-raf5rlkq 328 6 - - HYPH cord-302316-raf5rlkq 328 7 CoV-2-related cov-2-relate VBN cord-302316-raf5rlkq 328 8 coronavirus coronavirus NN cord-302316-raf5rlkq 328 9 from from IN cord-302316-raf5rlkq 328 10 malayan malayan JJ cord-302316-raf5rlkq 328 11 pangolins pangolin NNS cord-302316-raf5rlkq 329 1 Pathological pathological JJ cord-302316-raf5rlkq 329 2 findings finding NNS cord-302316-raf5rlkq 329 3 of of IN cord-302316-raf5rlkq 329 4 COVID-19 COVID-19 NNP cord-302316-raf5rlkq 329 5 associated associate VBN cord-302316-raf5rlkq 329 6 with with IN cord-302316-raf5rlkq 329 7 acute acute JJ cord-302316-raf5rlkq 329 8 respiratory respiratory JJ cord-302316-raf5rlkq 329 9 distress distress NN cord-302316-raf5rlkq 329 10 syndrome syndrome NN cord-302316-raf5rlkq 329 11 Effective effective JJ cord-302316-raf5rlkq 329 12 treatment treatment NN cord-302316-raf5rlkq 329 13 of of IN cord-302316-raf5rlkq 329 14 severe severe JJ cord-302316-raf5rlkq 329 15 COVID-19 covid-19 JJ cord-302316-raf5rlkq 329 16 patients patient NNS cord-302316-raf5rlkq 329 17 with with IN cord-302316-raf5rlkq 329 18 tocilizumab tocilizumab NNP cord-302316-raf5rlkq 329 19 Effect Effect NNP cord-302316-raf5rlkq 329 20 of of IN cord-302316-raf5rlkq 329 21 convalescent convalescent JJ cord-302316-raf5rlkq 329 22 plasma plasma NN cord-302316-raf5rlkq 329 23 therapy therapy NN cord-302316-raf5rlkq 329 24 on on IN cord-302316-raf5rlkq 329 25 viral viral JJ cord-302316-raf5rlkq 329 26 shedding shedding NN cord-302316-raf5rlkq 329 27 and and CC cord-302316-raf5rlkq 329 28 survival survival NN cord-302316-raf5rlkq 329 29 in in IN cord-302316-raf5rlkq 329 30 COVID-19 covid-19 JJ cord-302316-raf5rlkq 329 31 patients patient NNS cord-302316-raf5rlkq 330 1 SARS SARS NNP cord-302316-raf5rlkq 330 2 - - HYPH cord-302316-raf5rlkq 330 3 CoV-2 CoV-2 NNP cord-302316-raf5rlkq 330 4 receptor receptor NN cord-302316-raf5rlkq 330 5 ACE2 ACE2 NNP cord-302316-raf5rlkq 330 6 is be VBZ cord-302316-raf5rlkq 330 7 an an DT cord-302316-raf5rlkq 330 8 interferon interferon NN cord-302316-raf5rlkq 330 9 - - HYPH cord-302316-raf5rlkq 330 10 stimulated stimulate VBN cord-302316-raf5rlkq 330 11 gene gene NN cord-302316-raf5rlkq 330 12 in in IN cord-302316-raf5rlkq 330 13 human human JJ cord-302316-raf5rlkq 330 14 airway airway NN cord-302316-raf5rlkq 330 15 epithelial epithelial JJ cord-302316-raf5rlkq 330 16 cells cell NNS cord-302316-raf5rlkq 330 17 and and CC cord-302316-raf5rlkq 330 18 is be VBZ cord-302316-raf5rlkq 330 19 detected detect VBN cord-302316-raf5rlkq 330 20 in in IN cord-302316-raf5rlkq 330 21 specific specific JJ cord-302316-raf5rlkq 330 22 cell cell NN cord-302316-raf5rlkq 330 23 subsets subset NNS cord-302316-raf5rlkq 330 24 across across IN cord-302316-raf5rlkq 330 25 tissues tissue NNS cord-302316-raf5rlkq 331 1 I -PRON- PRP cord-302316-raf5rlkq 331 2 thank thank VBP cord-302316-raf5rlkq 331 3 Jacqueline Jacqueline NNP cord-302316-raf5rlkq 331 4 Steinhauser Steinhauser NNP cord-302316-raf5rlkq 331 5 , , , cord-302316-raf5rlkq 331 6 and and CC cord-302316-raf5rlkq 331 7 Kenneth Kenneth NNP cord-302316-raf5rlkq 331 8 Timmis Timmis NNP cord-302316-raf5rlkq 331 9 and and CC cord-302316-raf5rlkq 331 10 Lutz Lutz NNP cord-302316-raf5rlkq 331 11 Br€ Br€ NNP cord-302316-raf5rlkq 331 12 ussow ussow NN cord-302316-raf5rlkq 331 13 for for IN cord-302316-raf5rlkq 331 14 critical critical JJ cord-302316-raf5rlkq 331 15 reading reading NN cord-302316-raf5rlkq 331 16 of of IN cord-302316-raf5rlkq 331 17 the the DT cord-302316-raf5rlkq 331 18 manuscript manuscript NN cord-302316-raf5rlkq 331 19 . . . cord-302316-raf5rlkq 332 1 The the DT cord-302316-raf5rlkq 332 2 author author NN cord-302316-raf5rlkq 332 3 consults consult VBZ cord-302316-raf5rlkq 332 4 Nestl Nestl NNP cord-302316-raf5rlkq 332 5 e e NNP cord-302316-raf5rlkq 332 6 , , , cord-302316-raf5rlkq 332 7 his -PRON- PRP$ cord-302316-raf5rlkq 332 8 former former JJ cord-302316-raf5rlkq 332 9 employer employer NN cord-302316-raf5rlkq 332 10 , , , cord-302316-raf5rlkq 332 11 on on IN cord-302316-raf5rlkq 332 12 the the DT cord-302316-raf5rlkq 332 13 scientific scientific JJ cord-302316-raf5rlkq 332 14 aspects aspect NNS cord-302316-raf5rlkq 332 15 of of IN cord-302316-raf5rlkq 332 16 the the DT cord-302316-raf5rlkq 332 17 COVID-19 covid-19 JJ cord-302316-raf5rlkq 332 18 epidemic epidemic NN cord-302316-raf5rlkq 332 19 , , , cord-302316-raf5rlkq 332 20 but but CC cord-302316-raf5rlkq 332 21 he -PRON- PRP cord-302316-raf5rlkq 332 22 does do VBZ cord-302316-raf5rlkq 332 23 not not RB cord-302316-raf5rlkq 332 24 consider consider VB cord-302316-raf5rlkq 332 25 this this DT cord-302316-raf5rlkq 332 26 as as IN cord-302316-raf5rlkq 332 27 a a DT cord-302316-raf5rlkq 332 28 conflict conflict NN cord-302316-raf5rlkq 332 29 of of IN cord-302316-raf5rlkq 332 30 interest interest NN cord-302316-raf5rlkq 332 31 . . .