id sid tid token lemma pos cord-300850-59j1m2tm 1 1 key key JJ cord-300850-59j1m2tm 1 2 : : : cord-300850-59j1m2tm 1 3 cord-300850 cord-300850 NNP cord-300850-59j1m2tm 1 4 - - HYPH cord-300850-59j1m2tm 1 5 59j1m2tm 59j1m2tm CD cord-300850-59j1m2tm 1 6 authors author NNS cord-300850-59j1m2tm 1 7 : : : cord-300850-59j1m2tm 1 8 Peron Peron NNP cord-300850-59j1m2tm 1 9 , , , cord-300850-59j1m2tm 1 10 Jean Jean NNP cord-300850-59j1m2tm 1 11 Pierre Pierre NNP cord-300850-59j1m2tm 1 12 Schatzmann Schatzmann NNP cord-300850-59j1m2tm 1 13 ; ; : cord-300850-59j1m2tm 1 14 Nakaya Nakaya NNP cord-300850-59j1m2tm 1 15 , , , cord-300850-59j1m2tm 1 16 Helder Helder NNP cord-300850-59j1m2tm 1 17 title title NN cord-300850-59j1m2tm 1 18 : : : cord-300850-59j1m2tm 2 1 Susceptibility susceptibility NN cord-300850-59j1m2tm 2 2 of of IN cord-300850-59j1m2tm 2 3 the the DT cord-300850-59j1m2tm 2 4 Elderly Elderly NNP cord-300850-59j1m2tm 2 5 to to IN cord-300850-59j1m2tm 2 6 SARS SARS NNP cord-300850-59j1m2tm 2 7 - - HYPH cord-300850-59j1m2tm 2 8 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 2 9 Infection infection NN cord-300850-59j1m2tm 2 10 : : : cord-300850-59j1m2tm 2 11 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 2 12 Overexpression Overexpression NNP cord-300850-59j1m2tm 2 13 , , , cord-300850-59j1m2tm 2 14 Shedding shedding NN cord-300850-59j1m2tm 2 15 , , , cord-300850-59j1m2tm 2 16 and and CC cord-300850-59j1m2tm 2 17 Antibody antibody NN cord-300850-59j1m2tm 2 18 - - HYPH cord-300850-59j1m2tm 2 19 dependent dependent JJ cord-300850-59j1m2tm 2 20 Enhancement enhancement NN cord-300850-59j1m2tm 2 21 ( ( -LRB- cord-300850-59j1m2tm 2 22 ADE ADE NNP cord-300850-59j1m2tm 2 23 ) ) -RRB- cord-300850-59j1m2tm 2 24 date date NN cord-300850-59j1m2tm 2 25 : : : cord-300850-59j1m2tm 3 1 2020 2020 CD cord-300850-59j1m2tm 3 2 - - SYM cord-300850-59j1m2tm 3 3 05 05 CD cord-300850-59j1m2tm 3 4 - - HYPH cord-300850-59j1m2tm 3 5 11 11 CD cord-300850-59j1m2tm 3 6 journal journal NN cord-300850-59j1m2tm 3 7 : : : cord-300850-59j1m2tm 3 8 Clinics clinic NNS cord-300850-59j1m2tm 3 9 ( ( -LRB- cord-300850-59j1m2tm 3 10 Sao Sao NNP cord-300850-59j1m2tm 3 11 Paulo Paulo NNP cord-300850-59j1m2tm 3 12 ) ) -RRB- cord-300850-59j1m2tm 3 13 DOI DOI NNP cord-300850-59j1m2tm 3 14 : : : cord-300850-59j1m2tm 3 15 10.6061 10.6061 CD cord-300850-59j1m2tm 3 16 / / SYM cord-300850-59j1m2tm 3 17 clinics/2020/ clinics/2020/ VBD cord-300850-59j1m2tm 4 1 e1912 e1912 NNP cord-300850-59j1m2tm 4 2 sha sha NNP cord-300850-59j1m2tm 4 3 : : : cord-300850-59j1m2tm 4 4 f45e77badcf257bafe4d8817eb7319fb36fb6deb f45e77badcf257bafe4d8817eb7319fb36fb6deb NNP cord-300850-59j1m2tm 4 5 doc_id doc_id CD cord-300850-59j1m2tm 4 6 : : : cord-300850-59j1m2tm 4 7 300850 300850 CD cord-300850-59j1m2tm 4 8 cord_uid cord_uid NNS cord-300850-59j1m2tm 4 9 : : : cord-300850-59j1m2tm 4 10 59j1m2tm 59j1m2tm CD cord-300850-59j1m2tm 5 1 The the DT cord-300850-59j1m2tm 5 2 world world NN cord-300850-59j1m2tm 5 3 is be VBZ cord-300850-59j1m2tm 5 4 currently currently RB cord-300850-59j1m2tm 5 5 facing face VBG cord-300850-59j1m2tm 5 6 a a DT cord-300850-59j1m2tm 5 7 serious serious JJ cord-300850-59j1m2tm 5 8 SARS SARS NNP cord-300850-59j1m2tm 5 9 - - HYPH cord-300850-59j1m2tm 5 10 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 5 11 infection infection NN cord-300850-59j1m2tm 5 12 pandemic pandemic NN cord-300850-59j1m2tm 5 13 . . . cord-300850-59j1m2tm 6 1 This this DT cord-300850-59j1m2tm 6 2 virus virus NN cord-300850-59j1m2tm 6 3 is be VBZ cord-300850-59j1m2tm 6 4 a a DT cord-300850-59j1m2tm 6 5 new new JJ cord-300850-59j1m2tm 6 6 isolate isolate NN cord-300850-59j1m2tm 6 7 of of IN cord-300850-59j1m2tm 6 8 coronavirus coronavirus NN cord-300850-59j1m2tm 6 9 , , , cord-300850-59j1m2tm 6 10 and and CC cord-300850-59j1m2tm 6 11 the the DT cord-300850-59j1m2tm 6 12 current current JJ cord-300850-59j1m2tm 6 13 infection infection NN cord-300850-59j1m2tm 6 14 crisis crisis NN cord-300850-59j1m2tm 6 15 has have VBZ cord-300850-59j1m2tm 6 16 surpassed surpass VBN cord-300850-59j1m2tm 6 17 the the DT cord-300850-59j1m2tm 6 18 SARS SARS NNP cord-300850-59j1m2tm 6 19 and and CC cord-300850-59j1m2tm 6 20 MERS MERS NNP cord-300850-59j1m2tm 6 21 epidemics epidemic NNS cord-300850-59j1m2tm 6 22 that that WDT cord-300850-59j1m2tm 6 23 occurred occur VBD cord-300850-59j1m2tm 6 24 in in IN cord-300850-59j1m2tm 6 25 2002 2002 CD cord-300850-59j1m2tm 6 26 and and CC cord-300850-59j1m2tm 6 27 2013 2013 CD cord-300850-59j1m2tm 6 28 , , , cord-300850-59j1m2tm 6 29 respectively respectively RB cord-300850-59j1m2tm 6 30 . . . cord-300850-59j1m2tm 7 1 SARS SARS NNP cord-300850-59j1m2tm 7 2 - - HYPH cord-300850-59j1m2tm 7 3 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 7 4 has have VBZ cord-300850-59j1m2tm 7 5 currently currently RB cord-300850-59j1m2tm 7 6 infected infect VBN cord-300850-59j1m2tm 7 7 more more JJR cord-300850-59j1m2tm 7 8 than than IN cord-300850-59j1m2tm 7 9 142,000 142,000 CD cord-300850-59j1m2tm 7 10 people people NNS cord-300850-59j1m2tm 7 11 , , , cord-300850-59j1m2tm 7 12 causing cause VBG cord-300850-59j1m2tm 7 13 5,000 5,000 CD cord-300850-59j1m2tm 7 14 deaths death NNS cord-300850-59j1m2tm 7 15 and and CC cord-300850-59j1m2tm 7 16 spreading spread VBG cord-300850-59j1m2tm 7 17 across across IN cord-300850-59j1m2tm 7 18 more more JJR cord-300850-59j1m2tm 7 19 than than IN cord-300850-59j1m2tm 7 20 130 130 CD cord-300850-59j1m2tm 7 21 countries country NNS cord-300850-59j1m2tm 7 22 worldwide worldwide RB cord-300850-59j1m2tm 7 23 . . . cord-300850-59j1m2tm 8 1 The the DT cord-300850-59j1m2tm 8 2 spreading spread VBG cord-300850-59j1m2tm 8 3 capacity capacity NN cord-300850-59j1m2tm 8 4 of of IN cord-300850-59j1m2tm 8 5 the the DT cord-300850-59j1m2tm 8 6 virus virus NN cord-300850-59j1m2tm 8 7 clearly clearly RB cord-300850-59j1m2tm 8 8 demonstrates demonstrate VBZ cord-300850-59j1m2tm 8 9 the the DT cord-300850-59j1m2tm 8 10 potential potential JJ cord-300850-59j1m2tm 8 11 threat threat NN cord-300850-59j1m2tm 8 12 of of IN cord-300850-59j1m2tm 8 13 respiratory respiratory JJ cord-300850-59j1m2tm 8 14 viruses virus NNS cord-300850-59j1m2tm 8 15 to to IN cord-300850-59j1m2tm 8 16 human human JJ cord-300850-59j1m2tm 8 17 health health NN cord-300850-59j1m2tm 8 18 , , , cord-300850-59j1m2tm 8 19 thereby thereby RB cord-300850-59j1m2tm 8 20 reiterating reiterate VBG cord-300850-59j1m2tm 8 21 to to IN cord-300850-59j1m2tm 8 22 the the DT cord-300850-59j1m2tm 8 23 governments government NNS cord-300850-59j1m2tm 8 24 around around IN cord-300850-59j1m2tm 8 25 the the DT cord-300850-59j1m2tm 8 26 world world NN cord-300850-59j1m2tm 8 27 that that IN cord-300850-59j1m2tm 8 28 preventive preventive JJ cord-300850-59j1m2tm 8 29 health health NN cord-300850-59j1m2tm 8 30 policies policy NNS cord-300850-59j1m2tm 8 31 and and CC cord-300850-59j1m2tm 8 32 scientific scientific JJ cord-300850-59j1m2tm 8 33 research research NN cord-300850-59j1m2tm 8 34 are be VBP cord-300850-59j1m2tm 8 35 pivotal pivotal JJ cord-300850-59j1m2tm 8 36 to to IN cord-300850-59j1m2tm 8 37 overcoming overcome VBG cord-300850-59j1m2tm 8 38 the the DT cord-300850-59j1m2tm 8 39 crisis crisis NN cord-300850-59j1m2tm 8 40 . . . cord-300850-59j1m2tm 9 1 Coronavirus Coronavirus NNP cord-300850-59j1m2tm 9 2 disease disease NN cord-300850-59j1m2tm 9 3 ( ( -LRB- cord-300850-59j1m2tm 9 4 COVID-19 COVID-19 NNP cord-300850-59j1m2tm 9 5 ) ) -RRB- cord-300850-59j1m2tm 9 6 causes cause VBZ cord-300850-59j1m2tm 9 7 flu flu NN cord-300850-59j1m2tm 9 8 - - HYPH cord-300850-59j1m2tm 9 9 like like JJ cord-300850-59j1m2tm 9 10 symptoms symptom NNS cord-300850-59j1m2tm 9 11 in in IN cord-300850-59j1m2tm 9 12 most most JJS cord-300850-59j1m2tm 9 13 cases case NNS cord-300850-59j1m2tm 9 14 . . . cord-300850-59j1m2tm 10 1 However however RB cord-300850-59j1m2tm 10 2 , , , cord-300850-59j1m2tm 10 3 approximately approximately RB cord-300850-59j1m2tm 10 4 15 15 CD cord-300850-59j1m2tm 10 5 % % NN cord-300850-59j1m2tm 10 6 of of IN cord-300850-59j1m2tm 10 7 the the DT cord-300850-59j1m2tm 10 8 patients patient NNS cord-300850-59j1m2tm 10 9 need need VBP cord-300850-59j1m2tm 10 10 hospitalization hospitalization NN cord-300850-59j1m2tm 10 11 , , , cord-300850-59j1m2tm 10 12 and and CC cord-300850-59j1m2tm 10 13 5 5 CD cord-300850-59j1m2tm 10 14 % % NN cord-300850-59j1m2tm 10 15 require require VBP cord-300850-59j1m2tm 10 16 assisted assist VBN cord-300850-59j1m2tm 10 17 ventilation ventilation NN cord-300850-59j1m2tm 10 18 , , , cord-300850-59j1m2tm 10 19 depending depend VBG cord-300850-59j1m2tm 10 20 on on IN cord-300850-59j1m2tm 10 21 the the DT cord-300850-59j1m2tm 10 22 cohorts cohort NNS cord-300850-59j1m2tm 10 23 studied study VBD cord-300850-59j1m2tm 10 24 . . . cord-300850-59j1m2tm 11 1 What what WP cord-300850-59j1m2tm 11 2 is be VBZ cord-300850-59j1m2tm 11 3 intriguing intriguing JJ cord-300850-59j1m2tm 11 4 , , , cord-300850-59j1m2tm 11 5 however however RB cord-300850-59j1m2tm 11 6 , , , cord-300850-59j1m2tm 11 7 is be VBZ cord-300850-59j1m2tm 11 8 the the DT cord-300850-59j1m2tm 11 9 higher high JJR cord-300850-59j1m2tm 11 10 susceptibility susceptibility NN cord-300850-59j1m2tm 11 11 of of IN cord-300850-59j1m2tm 11 12 the the DT cord-300850-59j1m2tm 11 13 elderly elderly JJ cord-300850-59j1m2tm 11 14 , , , cord-300850-59j1m2tm 11 15 especially especially RB cord-300850-59j1m2tm 11 16 individuals individual NNS cord-300850-59j1m2tm 11 17 who who WP cord-300850-59j1m2tm 11 18 are be VBP cord-300850-59j1m2tm 11 19 older old JJR cord-300850-59j1m2tm 11 20 than than IN cord-300850-59j1m2tm 11 21 60 60 CD cord-300850-59j1m2tm 11 22 years year NNS cord-300850-59j1m2tm 11 23 of of IN cord-300850-59j1m2tm 11 24 age age NN cord-300850-59j1m2tm 11 25 , , , cord-300850-59j1m2tm 11 26 and and CC cord-300850-59j1m2tm 11 27 have have VBP cord-300850-59j1m2tm 11 28 comorbidities comorbiditie NNS cord-300850-59j1m2tm 11 29 , , , cord-300850-59j1m2tm 11 30 including include VBG cord-300850-59j1m2tm 11 31 hypertension hypertension NN cord-300850-59j1m2tm 11 32 , , , cord-300850-59j1m2tm 11 33 diabetes diabetes NN cord-300850-59j1m2tm 11 34 , , , cord-300850-59j1m2tm 11 35 and and CC cord-300850-59j1m2tm 11 36 heart heart NN cord-300850-59j1m2tm 11 37 disease disease NN cord-300850-59j1m2tm 11 38 . . . cord-300850-59j1m2tm 12 1 In in IN cord-300850-59j1m2tm 12 2 fact fact NN cord-300850-59j1m2tm 12 3 , , , cord-300850-59j1m2tm 12 4 the the DT cord-300850-59j1m2tm 12 5 death death NN cord-300850-59j1m2tm 12 6 rate rate NN cord-300850-59j1m2tm 12 7 in in IN cord-300850-59j1m2tm 12 8 this this DT cord-300850-59j1m2tm 12 9 group group NN cord-300850-59j1m2tm 12 10 may may MD cord-300850-59j1m2tm 12 11 be be VB cord-300850-59j1m2tm 12 12 up up IN cord-300850-59j1m2tm 12 13 to to TO cord-300850-59j1m2tm 12 14 10 10 CD cord-300850-59j1m2tm 12 15 - - SYM cord-300850-59j1m2tm 12 16 12 12 CD cord-300850-59j1m2tm 12 17 % % NN cord-300850-59j1m2tm 12 18 . . . cord-300850-59j1m2tm 13 1 Interestingly interestingly RB cord-300850-59j1m2tm 13 2 , , , cord-300850-59j1m2tm 13 3 children child NNS cord-300850-59j1m2tm 13 4 are be VBP cord-300850-59j1m2tm 13 5 somehow somehow RB cord-300850-59j1m2tm 13 6 less less RBR cord-300850-59j1m2tm 13 7 susceptible susceptible JJ cord-300850-59j1m2tm 13 8 and and CC cord-300850-59j1m2tm 13 9 are be VBP cord-300850-59j1m2tm 13 10 not not RB cord-300850-59j1m2tm 13 11 considered consider VBN cord-300850-59j1m2tm 13 12 as as IN cord-300850-59j1m2tm 13 13 a a DT cord-300850-59j1m2tm 13 14 risk risk NN cord-300850-59j1m2tm 13 15 group group NN cord-300850-59j1m2tm 13 16 . . . cord-300850-59j1m2tm 14 1 Therefore therefore RB cord-300850-59j1m2tm 14 2 , , , cord-300850-59j1m2tm 14 3 in in IN cord-300850-59j1m2tm 14 4 this this DT cord-300850-59j1m2tm 14 5 review review NN cord-300850-59j1m2tm 14 6 , , , cord-300850-59j1m2tm 14 7 we -PRON- PRP cord-300850-59j1m2tm 14 8 discuss discuss VBP cord-300850-59j1m2tm 14 9 some some DT cord-300850-59j1m2tm 14 10 possible possible JJ cord-300850-59j1m2tm 14 11 molecular molecular JJ cord-300850-59j1m2tm 14 12 and and CC cord-300850-59j1m2tm 14 13 cellular cellular JJ cord-300850-59j1m2tm 14 14 mechanisms mechanism NNS cord-300850-59j1m2tm 14 15 by by IN cord-300850-59j1m2tm 14 16 virtue virtue NN cord-300850-59j1m2tm 14 17 of of IN cord-300850-59j1m2tm 14 18 which which WDT cord-300850-59j1m2tm 14 19 the the DT cord-300850-59j1m2tm 14 20 elderly elderly JJ cord-300850-59j1m2tm 14 21 subjects subject NNS cord-300850-59j1m2tm 14 22 may may MD cord-300850-59j1m2tm 14 23 be be VB cord-300850-59j1m2tm 14 24 more more RBR cord-300850-59j1m2tm 14 25 susceptible susceptible JJ cord-300850-59j1m2tm 14 26 to to IN cord-300850-59j1m2tm 14 27 severe severe JJ cord-300850-59j1m2tm 14 28 COVID-19 covid-19 NN cord-300850-59j1m2tm 14 29 . . . cord-300850-59j1m2tm 15 1 Toward toward IN cord-300850-59j1m2tm 15 2 this this DT cord-300850-59j1m2tm 15 3 , , , cord-300850-59j1m2tm 15 4 we -PRON- PRP cord-300850-59j1m2tm 15 5 raise raise VBP cord-300850-59j1m2tm 15 6 two two CD cord-300850-59j1m2tm 15 7 main main JJ cord-300850-59j1m2tm 15 8 points point NNS cord-300850-59j1m2tm 15 9 , , , cord-300850-59j1m2tm 15 10 i i PRP cord-300850-59j1m2tm 15 11 ) ) -RRB- cord-300850-59j1m2tm 15 12 increased increase VBD cord-300850-59j1m2tm 15 13 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 15 14 expression expression NN cord-300850-59j1m2tm 15 15 in in IN cord-300850-59j1m2tm 15 16 pulmonary pulmonary NN cord-300850-59j1m2tm 15 17 and and CC cord-300850-59j1m2tm 15 18 heart heart NN cord-300850-59j1m2tm 15 19 tissues tissue NNS cord-300850-59j1m2tm 15 20 in in IN cord-300850-59j1m2tm 15 21 users user NNS cord-300850-59j1m2tm 15 22 of of IN cord-300850-59j1m2tm 15 23 chronic chronic JJ cord-300850-59j1m2tm 15 24 angiotensin angiotensin NN cord-300850-59j1m2tm 15 25 1 1 CD cord-300850-59j1m2tm 15 26 receptor receptor NN cord-300850-59j1m2tm 15 27 ( ( -LRB- cord-300850-59j1m2tm 15 28 AT1R AT1R NNP cord-300850-59j1m2tm 15 29 ) ) -RRB- cord-300850-59j1m2tm 15 30 blockers blocker NNS cord-300850-59j1m2tm 15 31 ; ; : cord-300850-59j1m2tm 15 32 and and CC cord-300850-59j1m2tm 15 33 ii ii LS cord-300850-59j1m2tm 15 34 ) ) -RRB- cord-300850-59j1m2tm 15 35 antibody antibody NN cord-300850-59j1m2tm 15 36 - - HYPH cord-300850-59j1m2tm 15 37 dependent dependent JJ cord-300850-59j1m2tm 15 38 enhancement enhancement NN cord-300850-59j1m2tm 15 39 ( ( -LRB- cord-300850-59j1m2tm 15 40 ADE ADE NNP cord-300850-59j1m2tm 15 41 ) ) -RRB- cord-300850-59j1m2tm 15 42 after after IN cord-300850-59j1m2tm 15 43 previous previous JJ cord-300850-59j1m2tm 15 44 exposure exposure NN cord-300850-59j1m2tm 15 45 to to IN cord-300850-59j1m2tm 15 46 other other JJ cord-300850-59j1m2tm 15 47 circulating circulate VBG cord-300850-59j1m2tm 15 48 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 15 49 . . . cord-300850-59j1m2tm 16 1 We -PRON- PRP cord-300850-59j1m2tm 16 2 believe believe VBP cord-300850-59j1m2tm 16 3 that that IN cord-300850-59j1m2tm 16 4 these these DT cord-300850-59j1m2tm 16 5 points point NNS cord-300850-59j1m2tm 16 6 are be VBP cord-300850-59j1m2tm 16 7 pivotal pivotal JJ cord-300850-59j1m2tm 16 8 for for IN cord-300850-59j1m2tm 16 9 a a DT cord-300850-59j1m2tm 16 10 better well JJR cord-300850-59j1m2tm 16 11 understanding understanding NN cord-300850-59j1m2tm 16 12 of of IN cord-300850-59j1m2tm 16 13 the the DT cord-300850-59j1m2tm 16 14 pathogenesis pathogenesis NN cord-300850-59j1m2tm 16 15 of of IN cord-300850-59j1m2tm 16 16 severe severe JJ cord-300850-59j1m2tm 16 17 COVID-19 covid-19 NN cord-300850-59j1m2tm 16 18 , , , cord-300850-59j1m2tm 16 19 and and CC cord-300850-59j1m2tm 16 20 must must MD cord-300850-59j1m2tm 16 21 be be VB cord-300850-59j1m2tm 16 22 carefully carefully RB cord-300850-59j1m2tm 16 23 addressed address VBN cord-300850-59j1m2tm 16 24 by by IN cord-300850-59j1m2tm 16 25 physicians physician NNS cord-300850-59j1m2tm 16 26 and and CC cord-300850-59j1m2tm 16 27 scientists scientist NNS cord-300850-59j1m2tm 16 28 in in IN cord-300850-59j1m2tm 16 29 the the DT cord-300850-59j1m2tm 16 30 field field NN cord-300850-59j1m2tm 16 31 . . . cord-300850-59j1m2tm 17 1 The the DT cord-300850-59j1m2tm 17 2 world world NN cord-300850-59j1m2tm 17 3 is be VBZ cord-300850-59j1m2tm 17 4 facing face VBG cord-300850-59j1m2tm 17 5 a a DT cord-300850-59j1m2tm 17 6 major major JJ cord-300850-59j1m2tm 17 7 public public JJ cord-300850-59j1m2tm 17 8 health health NN cord-300850-59j1m2tm 17 9 crisis crisis NN cord-300850-59j1m2tm 17 10 due due IN cord-300850-59j1m2tm 17 11 to to IN cord-300850-59j1m2tm 17 12 the the DT cord-300850-59j1m2tm 17 13 pandemic pandemic NN cord-300850-59j1m2tm 17 14 caused cause VBN cord-300850-59j1m2tm 17 15 by by IN cord-300850-59j1m2tm 17 16 a a DT cord-300850-59j1m2tm 17 17 recently recently RB cord-300850-59j1m2tm 17 18 - - HYPH cord-300850-59j1m2tm 17 19 described describe VBN cord-300850-59j1m2tm 17 20 coronavirus coronavirus NN cord-300850-59j1m2tm 17 21 , , , cord-300850-59j1m2tm 17 22 named name VBN cord-300850-59j1m2tm 17 23 SARS SARS NNP cord-300850-59j1m2tm 17 24 - - HYPH cord-300850-59j1m2tm 17 25 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 17 26 ( ( -LRB- cord-300850-59j1m2tm 17 27 1 1 CD cord-300850-59j1m2tm 17 28 ) ) -RRB- cord-300850-59j1m2tm 17 29 ( ( -LRB- cord-300850-59j1m2tm 17 30 2 2 LS cord-300850-59j1m2tm 17 31 ) ) -RRB- cord-300850-59j1m2tm 17 32 ( ( -LRB- cord-300850-59j1m2tm 17 33 3 3 CD cord-300850-59j1m2tm 17 34 ) ) -RRB- cord-300850-59j1m2tm 17 35 . . . cord-300850-59j1m2tm 18 1 Reaching reach VBG cord-300850-59j1m2tm 18 2 proportions proportion NNS cord-300850-59j1m2tm 18 3 that that WDT cord-300850-59j1m2tm 18 4 far far RB cord-300850-59j1m2tm 18 5 surpass surpass VBP cord-300850-59j1m2tm 18 6 those those DT cord-300850-59j1m2tm 18 7 of of IN cord-300850-59j1m2tm 18 8 SARS SARS NNP cord-300850-59j1m2tm 18 9 and and CC cord-300850-59j1m2tm 18 10 MERS MERS NNP cord-300850-59j1m2tm 18 11 , , , cord-300850-59j1m2tm 18 12 the the DT cord-300850-59j1m2tm 18 13 SARS SARS NNP cord-300850-59j1m2tm 18 14 - - HYPH cord-300850-59j1m2tm 18 15 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 18 16 epidemic epidemic NN cord-300850-59j1m2tm 18 17 started start VBD cord-300850-59j1m2tm 18 18 in in IN cord-300850-59j1m2tm 18 19 Wuhan Wuhan NNP cord-300850-59j1m2tm 18 20 , , , cord-300850-59j1m2tm 18 21 China China NNP cord-300850-59j1m2tm 18 22 in in IN cord-300850-59j1m2tm 18 23 December December NNP cord-300850-59j1m2tm 18 24 2019 2019 CD cord-300850-59j1m2tm 18 25 , , , cord-300850-59j1m2tm 18 26 but but CC cord-300850-59j1m2tm 18 27 has have VBZ cord-300850-59j1m2tm 18 28 now now RB cord-300850-59j1m2tm 18 29 spread spread VBN cord-300850-59j1m2tm 18 30 to to IN cord-300850-59j1m2tm 18 31 more more JJR cord-300850-59j1m2tm 18 32 than than IN cord-300850-59j1m2tm 18 33 130 130 CD cord-300850-59j1m2tm 18 34 countries country NNS cord-300850-59j1m2tm 18 35 worldwide worldwide RB cord-300850-59j1m2tm 18 36 and and CC cord-300850-59j1m2tm 18 37 has have VBZ cord-300850-59j1m2tm 18 38 infected infect VBN cord-300850-59j1m2tm 18 39 approximately approximately RB cord-300850-59j1m2tm 18 40 142,000 142,000 CD cord-300850-59j1m2tm 18 41 people people NNS cord-300850-59j1m2tm 18 42 , , , cord-300850-59j1m2tm 18 43 with with IN cord-300850-59j1m2tm 18 44 more more JJR cord-300850-59j1m2tm 18 45 than than IN cord-300850-59j1m2tm 18 46 5,000 5,000 CD cord-300850-59j1m2tm 18 47 deaths death NNS cord-300850-59j1m2tm 18 48 being be VBG cord-300850-59j1m2tm 18 49 attributed attribute VBN cord-300850-59j1m2tm 18 50 to to IN cord-300850-59j1m2tm 18 51 it -PRON- PRP cord-300850-59j1m2tm 18 52 ( ( -LRB- cord-300850-59j1m2tm 18 53 WHO who WP cord-300850-59j1m2tm 18 54 , , , cord-300850-59j1m2tm 18 55 March March NNP cord-300850-59j1m2tm 18 56 13 13 CD cord-300850-59j1m2tm 18 57 th th CD cord-300850-59j1m2tm 18 58 2020 2020 CD cord-300850-59j1m2tm 18 59 ) ) -RRB- cord-300850-59j1m2tm 18 60 ( ( -LRB- cord-300850-59j1m2tm 18 61 4 4 LS cord-300850-59j1m2tm 18 62 ) ) -RRB- cord-300850-59j1m2tm 18 63 . . . cord-300850-59j1m2tm 19 1 Sequencing sequencing NN cord-300850-59j1m2tm 19 2 analysis analysis NN cord-300850-59j1m2tm 19 3 of of IN cord-300850-59j1m2tm 19 4 the the DT cord-300850-59j1m2tm 19 5 viral viral JJ cord-300850-59j1m2tm 19 6 genome genome NN cord-300850-59j1m2tm 19 7 has have VBZ cord-300850-59j1m2tm 19 8 revealed reveal VBN cord-300850-59j1m2tm 19 9 mutations mutation NNS cord-300850-59j1m2tm 19 10 in in IN cord-300850-59j1m2tm 19 11 the the DT cord-300850-59j1m2tm 19 12 spike spike NN cord-300850-59j1m2tm 19 13 protein protein NN cord-300850-59j1m2tm 19 14 - - : cord-300850-59j1m2tm 19 15 which which WDT cord-300850-59j1m2tm 19 16 is be VBZ cord-300850-59j1m2tm 19 17 essential essential JJ cord-300850-59j1m2tm 19 18 for for IN cord-300850-59j1m2tm 19 19 SARS SARS NNP cord-300850-59j1m2tm 19 20 - - HYPH cord-300850-59j1m2tm 19 21 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 19 22 attachment attachment NN cord-300850-59j1m2tm 19 23 and and CC cord-300850-59j1m2tm 19 24 invasion invasion NN cord-300850-59j1m2tm 19 25 into into IN cord-300850-59j1m2tm 19 26 host host NN cord-300850-59j1m2tm 19 27 cells cell NNS cord-300850-59j1m2tm 19 28 - - : cord-300850-59j1m2tm 19 29 may may MD cord-300850-59j1m2tm 19 30 have have VB cord-300850-59j1m2tm 19 31 favored favor VBN cord-300850-59j1m2tm 19 32 the the DT cord-300850-59j1m2tm 19 33 spill spill NN cord-300850-59j1m2tm 19 34 over over RP cord-300850-59j1m2tm 19 35 from from IN cord-300850-59j1m2tm 19 36 bats bat NNS cord-300850-59j1m2tm 19 37 to to IN cord-300850-59j1m2tm 19 38 humans human NNS cord-300850-59j1m2tm 19 39 ( ( -LRB- cord-300850-59j1m2tm 19 40 1 1 CD cord-300850-59j1m2tm 19 41 ) ) -RRB- cord-300850-59j1m2tm 19 42 . . . cord-300850-59j1m2tm 20 1 Most Most JJS cord-300850-59j1m2tm 20 2 patients patient NNS cord-300850-59j1m2tm 20 3 infected infect VBN cord-300850-59j1m2tm 20 4 with with IN cord-300850-59j1m2tm 20 5 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 20 6 develop develop VBP cord-300850-59j1m2tm 20 7 a a DT cord-300850-59j1m2tm 20 8 mild mild JJ cord-300850-59j1m2tm 20 9 flu flu NN cord-300850-59j1m2tm 20 10 - - HYPH cord-300850-59j1m2tm 20 11 like like JJ cord-300850-59j1m2tm 20 12 disease disease NN cord-300850-59j1m2tm 20 13 , , , cord-300850-59j1m2tm 20 14 in in IN cord-300850-59j1m2tm 20 15 which which WDT cord-300850-59j1m2tm 20 16 the the DT cord-300850-59j1m2tm 20 17 most most RBS cord-300850-59j1m2tm 20 18 common common JJ cord-300850-59j1m2tm 20 19 symptoms symptom NNS cord-300850-59j1m2tm 20 20 are be VBP cord-300850-59j1m2tm 20 21 fever fever NN cord-300850-59j1m2tm 20 22 and and CC cord-300850-59j1m2tm 20 23 cough cough NN cord-300850-59j1m2tm 20 24 . . . cord-300850-59j1m2tm 21 1 However however RB cord-300850-59j1m2tm 21 2 , , , cord-300850-59j1m2tm 21 3 in in IN cord-300850-59j1m2tm 21 4 a a DT cord-300850-59j1m2tm 21 5 study study NN cord-300850-59j1m2tm 21 6 of of IN cord-300850-59j1m2tm 21 7 1,099 1,099 CD cord-300850-59j1m2tm 21 8 patients patient NNS cord-300850-59j1m2tm 21 9 from from IN cord-300850-59j1m2tm 21 10 552 552 CD cord-300850-59j1m2tm 21 11 hospitals hospital NNS cord-300850-59j1m2tm 21 12 from from IN cord-300850-59j1m2tm 21 13 30 30 CD cord-300850-59j1m2tm 21 14 provinces province NNS cord-300850-59j1m2tm 21 15 of of IN cord-300850-59j1m2tm 21 16 China China NNP cord-300850-59j1m2tm 21 17 in in IN cord-300850-59j1m2tm 21 18 2020 2020 CD cord-300850-59j1m2tm 21 19 , , , cord-300850-59j1m2tm 21 20 Guan Guan NNP cord-300850-59j1m2tm 21 21 W W NNP cord-300850-59j1m2tm 21 22 et et NNP cord-300850-59j1m2tm 21 23 al al NNP cord-300850-59j1m2tm 21 24 . . . cord-300850-59j1m2tm 22 1 ( ( -LRB- cord-300850-59j1m2tm 22 2 5 5 LS cord-300850-59j1m2tm 22 3 ) ) -RRB- cord-300850-59j1m2tm 22 4 , , , cord-300850-59j1m2tm 22 5 revealed reveal VBD cord-300850-59j1m2tm 22 6 that that IN cord-300850-59j1m2tm 22 7 15.7 15.7 CD cord-300850-59j1m2tm 22 8 % % NN cord-300850-59j1m2tm 22 9 of of IN cord-300850-59j1m2tm 22 10 the the DT cord-300850-59j1m2tm 22 11 patients patient NNS cord-300850-59j1m2tm 22 12 who who WP cord-300850-59j1m2tm 22 13 develop develop VBP cord-300850-59j1m2tm 22 14 severe severe JJ cord-300850-59j1m2tm 22 15 disease disease NN cord-300850-59j1m2tm 22 16 have have VBP cord-300850-59j1m2tm 22 17 increased increase VBN cord-300850-59j1m2tm 22 18 difficulty difficulty NN cord-300850-59j1m2tm 22 19 in in IN cord-300850-59j1m2tm 22 20 breathing breathing NN cord-300850-59j1m2tm 22 21 because because IN cord-300850-59j1m2tm 22 22 of of IN cord-300850-59j1m2tm 22 23 pneumonia pneumonia NN cord-300850-59j1m2tm 22 24 . . . cord-300850-59j1m2tm 23 1 Radiological radiological JJ cord-300850-59j1m2tm 23 2 imaging imaging NN cord-300850-59j1m2tm 23 3 of of IN cord-300850-59j1m2tm 23 4 the the DT cord-300850-59j1m2tm 23 5 lungs lung NNS cord-300850-59j1m2tm 23 6 revealed reveal VBD cord-300850-59j1m2tm 23 7 opacity opacity NN cord-300850-59j1m2tm 23 8 in in IN cord-300850-59j1m2tm 23 9 56.4 56.4 CD cord-300850-59j1m2tm 23 10 % % NN cord-300850-59j1m2tm 23 11 of of IN cord-300850-59j1m2tm 23 12 the the DT cord-300850-59j1m2tm 23 13 patients patient NNS cord-300850-59j1m2tm 23 14 . . . cord-300850-59j1m2tm 24 1 Approximately approximately RB cord-300850-59j1m2tm 24 2 2.7 2.7 CD cord-300850-59j1m2tm 24 3 % % NN cord-300850-59j1m2tm 24 4 of of IN cord-300850-59j1m2tm 24 5 the the DT cord-300850-59j1m2tm 24 6 patients patient NNS cord-300850-59j1m2tm 24 7 needed need VBD cord-300850-59j1m2tm 24 8 assisted assisted JJ cord-300850-59j1m2tm 24 9 ventilation ventilation NN cord-300850-59j1m2tm 24 10 , , , cord-300850-59j1m2tm 24 11 and and CC cord-300850-59j1m2tm 24 12 1.4 1.4 CD cord-300850-59j1m2tm 24 13 % % NN cord-300850-59j1m2tm 24 14 died die VBD cord-300850-59j1m2tm 24 15 ( ( -LRB- cord-300850-59j1m2tm 24 16 1 1 CD cord-300850-59j1m2tm 24 17 ) ) -RRB- cord-300850-59j1m2tm 24 18 . . . cord-300850-59j1m2tm 25 1 However however RB cord-300850-59j1m2tm 25 2 , , , cord-300850-59j1m2tm 25 3 coronavirus coronavirus NN cord-300850-59j1m2tm 25 4 disease disease NN cord-300850-59j1m2tm 25 5 ( ( -LRB- cord-300850-59j1m2tm 25 6 COVID-19 COVID-19 NNP cord-300850-59j1m2tm 25 7 ) ) -RRB- cord-300850-59j1m2tm 25 8 may may MD cord-300850-59j1m2tm 25 9 rapidly rapidly RB cord-300850-59j1m2tm 25 10 develop develop VB cord-300850-59j1m2tm 25 11 into into IN cord-300850-59j1m2tm 25 12 severe severe JJ cord-300850-59j1m2tm 25 13 acute acute JJ cord-300850-59j1m2tm 25 14 respiratory respiratory JJ cord-300850-59j1m2tm 25 15 syndrome syndrome NN cord-300850-59j1m2tm 25 16 ( ( -LRB- cord-300850-59j1m2tm 25 17 SARS SARS NNP cord-300850-59j1m2tm 25 18 ) ) -RRB- cord-300850-59j1m2tm 25 19 in in IN cord-300850-59j1m2tm 25 20 elderly elderly JJ cord-300850-59j1m2tm 25 21 subjects subject NNS cord-300850-59j1m2tm 25 22 ( ( -LRB- cord-300850-59j1m2tm 25 23 460 460 CD cord-300850-59j1m2tm 25 24 yr yr NN cord-300850-59j1m2tm 25 25 ) ) -RRB- cord-300850-59j1m2tm 25 26 , , , cord-300850-59j1m2tm 25 27 especially especially RB cord-300850-59j1m2tm 25 28 in in IN cord-300850-59j1m2tm 25 29 those those DT cord-300850-59j1m2tm 25 30 with with IN cord-300850-59j1m2tm 25 31 comorbidities comorbiditie NNS cord-300850-59j1m2tm 25 32 , , , cord-300850-59j1m2tm 25 33 such such JJ cord-300850-59j1m2tm 25 34 as as IN cord-300850-59j1m2tm 25 35 hypertension hypertension NN cord-300850-59j1m2tm 25 36 , , , cord-300850-59j1m2tm 25 37 diabetes diabetes NN cord-300850-59j1m2tm 25 38 , , , cord-300850-59j1m2tm 25 39 and and CC cord-300850-59j1m2tm 25 40 pulmonary pulmonary JJ cord-300850-59j1m2tm 25 41 diseases disease NNS cord-300850-59j1m2tm 25 42 ( ( -LRB- cord-300850-59j1m2tm 25 43 1 1 CD cord-300850-59j1m2tm 25 44 , , , cord-300850-59j1m2tm 25 45 4 4 CD cord-300850-59j1m2tm 25 46 , , , cord-300850-59j1m2tm 25 47 6 6 CD cord-300850-59j1m2tm 25 48 ) ) -RRB- cord-300850-59j1m2tm 25 49 . . . cord-300850-59j1m2tm 26 1 What what WP cord-300850-59j1m2tm 26 2 is be VBZ cord-300850-59j1m2tm 26 3 intriguing intriguing JJ cord-300850-59j1m2tm 26 4 is be VBZ cord-300850-59j1m2tm 26 5 that that IN cord-300850-59j1m2tm 26 6 , , , cord-300850-59j1m2tm 26 7 unlike unlike IN cord-300850-59j1m2tm 26 8 in in IN cord-300850-59j1m2tm 26 9 the the DT cord-300850-59j1m2tm 26 10 case case NN cord-300850-59j1m2tm 26 11 of of IN cord-300850-59j1m2tm 26 12 influenza influenza NN cord-300850-59j1m2tm 26 13 ( ( -LRB- cord-300850-59j1m2tm 26 14 7 7 CD cord-300850-59j1m2tm 26 15 ) ) -RRB- cord-300850-59j1m2tm 26 16 , , , cord-300850-59j1m2tm 26 17 children child NNS cord-300850-59j1m2tm 26 18 are be VBP cord-300850-59j1m2tm 26 19 not not RB cord-300850-59j1m2tm 26 20 included include VBN cord-300850-59j1m2tm 26 21 in in IN cord-300850-59j1m2tm 26 22 the the DT cord-300850-59j1m2tm 26 23 risk risk NN cord-300850-59j1m2tm 26 24 group group NN cord-300850-59j1m2tm 26 25 , , , cord-300850-59j1m2tm 26 26 as as IN cord-300850-59j1m2tm 26 27 very very RB cord-300850-59j1m2tm 26 28 few few JJ cord-300850-59j1m2tm 26 29 cases case NNS cord-300850-59j1m2tm 26 30 of of IN cord-300850-59j1m2tm 26 31 severe severe JJ cord-300850-59j1m2tm 26 32 COVID-19 covid-19 NN cord-300850-59j1m2tm 26 33 in in IN cord-300850-59j1m2tm 26 34 children child NNS cord-300850-59j1m2tm 26 35 have have VBP cord-300850-59j1m2tm 26 36 been be VBN cord-300850-59j1m2tm 26 37 reported report VBN cord-300850-59j1m2tm 26 38 , , , cord-300850-59j1m2tm 26 39 and and CC cord-300850-59j1m2tm 26 40 there there EX cord-300850-59j1m2tm 26 41 have have VBP cord-300850-59j1m2tm 26 42 been be VBN cord-300850-59j1m2tm 26 43 no no DT cord-300850-59j1m2tm 26 44 reports report NNS cord-300850-59j1m2tm 26 45 of of IN cord-300850-59j1m2tm 26 46 death death NN cord-300850-59j1m2tm 26 47 in in IN cord-300850-59j1m2tm 26 48 children child NNS cord-300850-59j1m2tm 26 49 under under IN cord-300850-59j1m2tm 26 50 the the DT cord-300850-59j1m2tm 26 51 age age NN cord-300850-59j1m2tm 26 52 of of IN cord-300850-59j1m2tm 26 53 9 9 CD cord-300850-59j1m2tm 26 54 . . . cord-300850-59j1m2tm 27 1 This this DT cord-300850-59j1m2tm 27 2 raises raise VBZ cord-300850-59j1m2tm 27 3 questions question NNS cord-300850-59j1m2tm 27 4 regarding regard VBG cord-300850-59j1m2tm 27 5 the the DT cord-300850-59j1m2tm 27 6 cellular cellular JJ cord-300850-59j1m2tm 27 7 and and CC cord-300850-59j1m2tm 27 8 molecular molecular JJ cord-300850-59j1m2tm 27 9 mechanisms mechanism NNS cord-300850-59j1m2tm 27 10 associated associate VBN cord-300850-59j1m2tm 27 11 with with IN cord-300850-59j1m2tm 27 12 the the DT cord-300850-59j1m2tm 27 13 severity severity NN cord-300850-59j1m2tm 27 14 of of IN cord-300850-59j1m2tm 27 15 COVID-19 COVID-19 NNP cord-300850-59j1m2tm 27 16 . . . cord-300850-59j1m2tm 28 1 Understanding understand VBG cord-300850-59j1m2tm 28 2 and and CC cord-300850-59j1m2tm 28 3 elucidating elucidate VBG cord-300850-59j1m2tm 28 4 such such JJ cord-300850-59j1m2tm 28 5 mechanisms mechanism NNS cord-300850-59j1m2tm 28 6 may may MD cord-300850-59j1m2tm 28 7 greatly greatly RB cord-300850-59j1m2tm 28 8 improve improve VB cord-300850-59j1m2tm 28 9 our -PRON- PRP$ cord-300850-59j1m2tm 28 10 knowledge knowledge NN cord-300850-59j1m2tm 28 11 of of IN cord-300850-59j1m2tm 28 12 the the DT cord-300850-59j1m2tm 28 13 pathogenesis pathogenesis NN cord-300850-59j1m2tm 28 14 of of IN cord-300850-59j1m2tm 28 15 the the DT cord-300850-59j1m2tm 28 16 disease disease NN cord-300850-59j1m2tm 28 17 , , , cord-300850-59j1m2tm 28 18 and and CC cord-300850-59j1m2tm 28 19 thus thus RB cord-300850-59j1m2tm 28 20 guide guide VB cord-300850-59j1m2tm 28 21 health health NN cord-300850-59j1m2tm 28 22 professionals professional NNS cord-300850-59j1m2tm 28 23 as as IN cord-300850-59j1m2tm 28 24 to to IN cord-300850-59j1m2tm 28 25 how how WRB cord-300850-59j1m2tm 28 26 to to TO cord-300850-59j1m2tm 28 27 better better RB cord-300850-59j1m2tm 28 28 treat treat VB cord-300850-59j1m2tm 28 29 the the DT cord-300850-59j1m2tm 28 30 elderly elderly JJ cord-300850-59j1m2tm 28 31 population population NN cord-300850-59j1m2tm 28 32 . . . cord-300850-59j1m2tm 29 1 Toward toward IN cord-300850-59j1m2tm 29 2 this this DT cord-300850-59j1m2tm 29 3 , , , cord-300850-59j1m2tm 29 4 we -PRON- PRP cord-300850-59j1m2tm 29 5 raise raise VBP cord-300850-59j1m2tm 29 6 two two CD cord-300850-59j1m2tm 29 7 main main JJ cord-300850-59j1m2tm 29 8 points point NNS cord-300850-59j1m2tm 29 9 of of IN cord-300850-59j1m2tm 29 10 discussion discussion NN cord-300850-59j1m2tm 29 11 , , , cord-300850-59j1m2tm 29 12 i i PRP cord-300850-59j1m2tm 29 13 ) ) -RRB- cord-300850-59j1m2tm 29 14 the the DT cord-300850-59j1m2tm 29 15 increased increase VBN cord-300850-59j1m2tm 29 16 angiotensin angiotensin NN cord-300850-59j1m2tm 29 17 - - HYPH cord-300850-59j1m2tm 29 18 converting convert VBG cord-300850-59j1m2tm 29 19 enzyme-2 enzyme-2 NNP cord-300850-59j1m2tm 29 20 ( ( -LRB- cord-300850-59j1m2tm 29 21 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 29 22 ) ) -RRB- cord-300850-59j1m2tm 29 23 expression expression NN cord-300850-59j1m2tm 29 24 in in IN cord-300850-59j1m2tm 29 25 pulmonary pulmonary NN cord-300850-59j1m2tm 29 26 and and CC cord-300850-59j1m2tm 29 27 heart heart NN cord-300850-59j1m2tm 29 28 tissues tissue NNS cord-300850-59j1m2tm 29 29 of of IN cord-300850-59j1m2tm 29 30 hypertensive hypertensive JJ cord-300850-59j1m2tm 29 31 patients patient NNS cord-300850-59j1m2tm 29 32 with with IN cord-300850-59j1m2tm 29 33 chronic chronic JJ cord-300850-59j1m2tm 29 34 use use NN cord-300850-59j1m2tm 29 35 of of IN cord-300850-59j1m2tm 29 36 AT1R AT1R NNS cord-300850-59j1m2tm 29 37 blockers blocker NNS cord-300850-59j1m2tm 29 38 and and CC cord-300850-59j1m2tm 29 39 ii ii LS cord-300850-59j1m2tm 29 40 ) ) -RRB- cord-300850-59j1m2tm 29 41 antibody antibody NN cord-300850-59j1m2tm 29 42 - - HYPH cord-300850-59j1m2tm 29 43 dependent dependent JJ cord-300850-59j1m2tm 29 44 enhancement enhancement NN cord-300850-59j1m2tm 29 45 ( ( -LRB- cord-300850-59j1m2tm 29 46 ADE ADE NNP cord-300850-59j1m2tm 29 47 ) ) -RRB- cord-300850-59j1m2tm 29 48 after after IN cord-300850-59j1m2tm 29 49 previous previous JJ cord-300850-59j1m2tm 29 50 exposure exposure NN cord-300850-59j1m2tm 29 51 to to IN cord-300850-59j1m2tm 29 52 other other JJ cord-300850-59j1m2tm 29 53 circulating circulate VBG cord-300850-59j1m2tm 29 54 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 29 55 . . . cord-300850-59j1m2tm 30 1 After after IN cord-300850-59j1m2tm 30 2 entering enter VBG cord-300850-59j1m2tm 30 3 the the DT cord-300850-59j1m2tm 30 4 host host NN cord-300850-59j1m2tm 30 5 - - : cord-300850-59j1m2tm 30 6 usually usually RB cord-300850-59j1m2tm 30 7 through through IN cord-300850-59j1m2tm 30 8 aerosolized aerosolize VBN cord-300850-59j1m2tm 30 9 viral viral JJ cord-300850-59j1m2tm 30 10 particles particle NNS cord-300850-59j1m2tm 30 11 or or CC cord-300850-59j1m2tm 30 12 contact contact NN cord-300850-59j1m2tm 30 13 with with IN cord-300850-59j1m2tm 30 14 contaminated contaminated JJ cord-300850-59j1m2tm 30 15 surfaces surface NNS cord-300850-59j1m2tm 30 16 - - : cord-300850-59j1m2tm 30 17 the the DT cord-300850-59j1m2tm 30 18 virus virus NN cord-300850-59j1m2tm 30 19 needs need VBZ cord-300850-59j1m2tm 30 20 to to TO cord-300850-59j1m2tm 30 21 undergo undergo VB cord-300850-59j1m2tm 30 22 its -PRON- PRP$ cord-300850-59j1m2tm 30 23 biological biological JJ cord-300850-59j1m2tm 30 24 cycle cycle NN cord-300850-59j1m2tm 30 25 . . . cord-300850-59j1m2tm 31 1 Spike spike NN cord-300850-59j1m2tm 31 2 proteins protein NNS cord-300850-59j1m2tm 31 3 - - : cord-300850-59j1m2tm 31 4 that that WDT cord-300850-59j1m2tm 31 5 are be VBP cord-300850-59j1m2tm 31 6 coded code VBN cord-300850-59j1m2tm 31 7 by by IN cord-300850-59j1m2tm 31 8 the the DT cord-300850-59j1m2tm 31 9 S S NNP cord-300850-59j1m2tm 31 10 gene gene NN cord-300850-59j1m2tm 31 11 in in IN cord-300850-59j1m2tm 31 12 one one CD cord-300850-59j1m2tm 31 13 of of IN cord-300850-59j1m2tm 31 14 the the DT cord-300850-59j1m2tm 31 15 open open JJ cord-300850-59j1m2tm 31 16 reading reading NN cord-300850-59j1m2tm 31 17 frames frame NNS cord-300850-59j1m2tm 31 18 of of IN cord-300850-59j1m2tm 31 19 the the DT cord-300850-59j1m2tm 31 20 viral viral JJ cord-300850-59j1m2tm 31 21 genome genome NN cord-300850-59j1m2tm 31 22 - - : cord-300850-59j1m2tm 31 23 need need NN cord-300850-59j1m2tm 31 24 to to TO cord-300850-59j1m2tm 31 25 interact interact VB cord-300850-59j1m2tm 31 26 with with IN cord-300850-59j1m2tm 31 27 viral viral JJ cord-300850-59j1m2tm 31 28 receptors receptor NNS cord-300850-59j1m2tm 31 29 on on IN cord-300850-59j1m2tm 31 30 the the DT cord-300850-59j1m2tm 31 31 surface surface NN cord-300850-59j1m2tm 31 32 of of IN cord-300850-59j1m2tm 31 33 host host NN cord-300850-59j1m2tm 31 34 cells cell NNS cord-300850-59j1m2tm 31 35 . . . cord-300850-59j1m2tm 32 1 SARS SARS NNP cord-300850-59j1m2tm 32 2 - - HYPH cord-300850-59j1m2tm 32 3 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 32 4 spike spike NN cord-300850-59j1m2tm 32 5 proteins protein NNS cord-300850-59j1m2tm 32 6 bind bind VBP cord-300850-59j1m2tm 32 7 to to IN cord-300850-59j1m2tm 32 8 angiotensin angiotensin NN cord-300850-59j1m2tm 32 9 - - HYPH cord-300850-59j1m2tm 32 10 converting convert VBG cord-300850-59j1m2tm 32 11 enzyme-2 enzyme-2 NNP cord-300850-59j1m2tm 33 1 ( ( -LRB- cord-300850-59j1m2tm 33 2 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 33 3 ) ) -RRB- cord-300850-59j1m2tm 33 4 , , , cord-300850-59j1m2tm 33 5 which which WDT cord-300850-59j1m2tm 33 6 is be VBZ cord-300850-59j1m2tm 33 7 expressed express VBN cord-300850-59j1m2tm 33 8 in in IN cord-300850-59j1m2tm 33 9 the the DT cord-300850-59j1m2tm 33 10 epithelial epithelial JJ cord-300850-59j1m2tm 33 11 cells cell NNS cord-300850-59j1m2tm 33 12 of of IN cord-300850-59j1m2tm 33 13 the the DT cord-300850-59j1m2tm 33 14 lungs lung NNS cord-300850-59j1m2tm 33 15 ( ( -LRB- cord-300850-59j1m2tm 33 16 8 8 CD cord-300850-59j1m2tm 33 17 , , , cord-300850-59j1m2tm 33 18 9 9 CD cord-300850-59j1m2tm 33 19 ) ) -RRB- cord-300850-59j1m2tm 33 20 . . . cord-300850-59j1m2tm 34 1 This this DT cord-300850-59j1m2tm 34 2 is be VBZ cord-300850-59j1m2tm 34 3 the the DT cord-300850-59j1m2tm 34 4 main main JJ cord-300850-59j1m2tm 34 5 reason reason NN cord-300850-59j1m2tm 34 6 why why WRB cord-300850-59j1m2tm 34 7 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 34 8 often often RB cord-300850-59j1m2tm 34 9 cause cause VBP cord-300850-59j1m2tm 34 10 respiratory respiratory JJ cord-300850-59j1m2tm 34 11 disease disease NN cord-300850-59j1m2tm 34 12 . . . cord-300850-59j1m2tm 35 1 Notably notably RB cord-300850-59j1m2tm 35 2 , , , cord-300850-59j1m2tm 35 3 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 35 4 may may MD cord-300850-59j1m2tm 35 5 also also RB cord-300850-59j1m2tm 35 6 be be VB cord-300850-59j1m2tm 35 7 highly highly RB cord-300850-59j1m2tm 35 8 expressed express VBN cord-300850-59j1m2tm 35 9 in in IN cord-300850-59j1m2tm 35 10 intestinal intestinal JJ cord-300850-59j1m2tm 35 11 tissues tissue NNS cord-300850-59j1m2tm 35 12 ( ( -LRB- cord-300850-59j1m2tm 35 13 9 9 CD cord-300850-59j1m2tm 35 14 ) ) -RRB- cord-300850-59j1m2tm 35 15 , , , cord-300850-59j1m2tm 35 16 leading lead VBG cord-300850-59j1m2tm 35 17 to to IN cord-300850-59j1m2tm 35 18 diarrhea diarrhea NN cord-300850-59j1m2tm 35 19 , , , cord-300850-59j1m2tm 35 20 as as IN cord-300850-59j1m2tm 35 21 observed observe VBN cord-300850-59j1m2tm 35 22 in in IN cord-300850-59j1m2tm 35 23 60 60 CD cord-300850-59j1m2tm 35 24 % % NN cord-300850-59j1m2tm 35 25 of of IN cord-300850-59j1m2tm 35 26 the the DT cord-300850-59j1m2tm 35 27 patients patient NNS cord-300850-59j1m2tm 35 28 during during IN cord-300850-59j1m2tm 35 29 the the DT cord-300850-59j1m2tm 35 30 SARS SARS NNP cord-300850-59j1m2tm 35 31 - - HYPH cord-300850-59j1m2tm 35 32 CoV CoV NNP cord-300850-59j1m2tm 35 33 epidemic epidemic NN cord-300850-59j1m2tm 35 34 in in IN cord-300850-59j1m2tm 35 35 2002 2002 CD cord-300850-59j1m2tm 35 36 . . . cord-300850-59j1m2tm 36 1 Only only RB cord-300850-59j1m2tm 36 2 a a DT cord-300850-59j1m2tm 36 3 few few JJ cord-300850-59j1m2tm 36 4 patients patient NNS cord-300850-59j1m2tm 36 5 with with IN cord-300850-59j1m2tm 36 6 SARS SARS NNP cord-300850-59j1m2tm 36 7 - - HYPH cord-300850-59j1m2tm 36 8 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 36 9 infection infection NN cord-300850-59j1m2tm 36 10 had have VBD cord-300850-59j1m2tm 36 11 diarrhea diarrhea NN cord-300850-59j1m2tm 36 12 , , , cord-300850-59j1m2tm 36 13 although although IN cord-300850-59j1m2tm 36 14 viral viral JJ cord-300850-59j1m2tm 36 15 particles particle NNS cord-300850-59j1m2tm 36 16 may may MD cord-300850-59j1m2tm 36 17 be be VB cord-300850-59j1m2tm 36 18 detected detect VBN cord-300850-59j1m2tm 36 19 in in IN cord-300850-59j1m2tm 36 20 the the DT cord-300850-59j1m2tm 36 21 stool stool NN cord-300850-59j1m2tm 36 22 ( ( -LRB- cord-300850-59j1m2tm 36 23 10 10 CD cord-300850-59j1m2tm 36 24 ) ) -RRB- cord-300850-59j1m2tm 36 25 . . . cord-300850-59j1m2tm 37 1 After after IN cord-300850-59j1m2tm 37 2 attaching attach VBG cord-300850-59j1m2tm 37 3 to to IN cord-300850-59j1m2tm 37 4 the the DT cord-300850-59j1m2tm 37 5 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 37 6 through through IN cord-300850-59j1m2tm 37 7 the the DT cord-300850-59j1m2tm 37 8 receptor receptor NN cord-300850-59j1m2tm 37 9 - - HYPH cord-300850-59j1m2tm 37 10 binding bind VBG cord-300850-59j1m2tm 37 11 domain domain NN cord-300850-59j1m2tm 37 12 ( ( -LRB- cord-300850-59j1m2tm 37 13 RBD RBD NNP cord-300850-59j1m2tm 37 14 ) ) -RRB- cord-300850-59j1m2tm 37 15 of of IN cord-300850-59j1m2tm 37 16 the the DT cord-300850-59j1m2tm 37 17 S1 S1 NNP cord-300850-59j1m2tm 37 18 and and CC cord-300850-59j1m2tm 37 19 S2 s2 NN cord-300850-59j1m2tm 37 20 domains domain NNS cord-300850-59j1m2tm 37 21 of of IN cord-300850-59j1m2tm 37 22 the the DT cord-300850-59j1m2tm 37 23 spike spike NN cord-300850-59j1m2tm 37 24 protein protein NN cord-300850-59j1m2tm 37 25 , , , cord-300850-59j1m2tm 37 26 the the DT cord-300850-59j1m2tm 37 27 viral viral JJ cord-300850-59j1m2tm 37 28 envelope envelope NN cord-300850-59j1m2tm 37 29 fuses fuse VBZ cord-300850-59j1m2tm 37 30 with with IN cord-300850-59j1m2tm 37 31 the the DT cord-300850-59j1m2tm 37 32 host host NN cord-300850-59j1m2tm 37 33 cell cell NN cord-300850-59j1m2tm 37 34 membrane membrane NN cord-300850-59j1m2tm 37 35 and and CC cord-300850-59j1m2tm 37 36 is be VBZ cord-300850-59j1m2tm 37 37 further further RB cord-300850-59j1m2tm 37 38 internalized internalize VBN cord-300850-59j1m2tm 37 39 . . . cord-300850-59j1m2tm 38 1 Genetic genetic JJ cord-300850-59j1m2tm 38 2 material material NN cord-300850-59j1m2tm 38 3 , , , cord-300850-59j1m2tm 38 4 a a DT cord-300850-59j1m2tm 38 5 positive positive JJ cord-300850-59j1m2tm 38 6 RNA RNA NNP cord-300850-59j1m2tm 38 7 strand strand NN cord-300850-59j1m2tm 38 8 of of IN cord-300850-59j1m2tm 38 9 approximately approximately RB cord-300850-59j1m2tm 38 10 20 20 CD cord-300850-59j1m2tm 38 11 - - SYM cord-300850-59j1m2tm 38 12 32 32 CD cord-300850-59j1m2tm 38 13 kb kb NNP cord-300850-59j1m2tm 38 14 , , , cord-300850-59j1m2tm 38 15 is be VBZ cord-300850-59j1m2tm 38 16 released release VBN cord-300850-59j1m2tm 38 17 into into IN cord-300850-59j1m2tm 38 18 the the DT cord-300850-59j1m2tm 38 19 cytoplasm cytoplasm NN cord-300850-59j1m2tm 38 20 for for IN cord-300850-59j1m2tm 38 21 replication replication NN cord-300850-59j1m2tm 38 22 ( ( -LRB- cord-300850-59j1m2tm 38 23 1 1 CD cord-300850-59j1m2tm 38 24 ) ) -RRB- cord-300850-59j1m2tm 38 25 . . . cord-300850-59j1m2tm 39 1 Thus thus RB cord-300850-59j1m2tm 39 2 , , , cord-300850-59j1m2tm 39 3 the the DT cord-300850-59j1m2tm 39 4 importance importance NN cord-300850-59j1m2tm 39 5 of of IN cord-300850-59j1m2tm 39 6 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 39 7 expression expression NN cord-300850-59j1m2tm 39 8 dynamics dynamic NNS cord-300850-59j1m2tm 39 9 for for IN cord-300850-59j1m2tm 39 10 viral viral JJ cord-300850-59j1m2tm 39 11 infectivity infectivity NN cord-300850-59j1m2tm 39 12 , , , cord-300850-59j1m2tm 39 13 tropism tropism NN cord-300850-59j1m2tm 39 14 , , , cord-300850-59j1m2tm 39 15 and and CC cord-300850-59j1m2tm 39 16 pathogenicity pathogenicity NN cord-300850-59j1m2tm 39 17 is be VBZ cord-300850-59j1m2tm 39 18 evident evident JJ cord-300850-59j1m2tm 39 19 . . . cord-300850-59j1m2tm 40 1 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 40 2 , , , cord-300850-59j1m2tm 40 3 or or CC cord-300850-59j1m2tm 40 4 ACE ace NN cord-300850-59j1m2tm 40 5 - - HYPH cord-300850-59j1m2tm 40 6 related relate VBN cord-300850-59j1m2tm 40 7 carboxypeptidase carboxypeptidase NN cord-300850-59j1m2tm 40 8 , , , cord-300850-59j1m2tm 40 9 is be VBZ cord-300850-59j1m2tm 40 10 an an DT cord-300850-59j1m2tm 40 11 805 805 CD cord-300850-59j1m2tm 40 12 amino amino NN cord-300850-59j1m2tm 40 13 acid acid NN cord-300850-59j1m2tm 40 14 transmembrane transmembrane NN cord-300850-59j1m2tm 40 15 protein protein NN cord-300850-59j1m2tm 40 16 which which WDT cord-300850-59j1m2tm 40 17 is be VBZ cord-300850-59j1m2tm 40 18 an an DT cord-300850-59j1m2tm 40 19 important important JJ cord-300850-59j1m2tm 40 20 member member NN cord-300850-59j1m2tm 40 21 of of IN cord-300850-59j1m2tm 40 22 the the DT cord-300850-59j1m2tm 40 23 renin renin NN cord-300850-59j1m2tm 40 24 - - HYPH cord-300850-59j1m2tm 40 25 angiotensin angiotensin NN cord-300850-59j1m2tm 40 26 system system NN cord-300850-59j1m2tm 40 27 that that WDT cord-300850-59j1m2tm 40 28 plays play VBZ cord-300850-59j1m2tm 40 29 a a DT cord-300850-59j1m2tm 40 30 pivotal pivotal JJ cord-300850-59j1m2tm 40 31 role role NN cord-300850-59j1m2tm 40 32 in in IN cord-300850-59j1m2tm 40 33 the the DT cord-300850-59j1m2tm 40 34 regulation regulation NN cord-300850-59j1m2tm 40 35 of of IN cord-300850-59j1m2tm 40 36 blood blood NN cord-300850-59j1m2tm 40 37 pressure pressure NN cord-300850-59j1m2tm 40 38 ( ( -LRB- cord-300850-59j1m2tm 40 39 11 11 CD cord-300850-59j1m2tm 40 40 ) ) -RRB- cord-300850-59j1m2tm 40 41 . . . cord-300850-59j1m2tm 41 1 ACE ace NN cord-300850-59j1m2tm 41 2 converts convert VBZ cord-300850-59j1m2tm 42 1 angiotensin angiotensin NNP cord-300850-59j1m2tm 43 1 I -PRON- PRP cord-300850-59j1m2tm 43 2 ( ( -LRB- cord-300850-59j1m2tm 43 3 Ang Ang NNP cord-300850-59j1m2tm 43 4 I I NNP cord-300850-59j1m2tm 43 5 ) ) -RRB- cord-300850-59j1m2tm 43 6 into into IN cord-300850-59j1m2tm 43 7 angiotensin angiotensin NN cord-300850-59j1m2tm 43 8 II II NNP cord-300850-59j1m2tm 43 9 ( ( -LRB- cord-300850-59j1m2tm 43 10 Ang Ang NNP cord-300850-59j1m2tm 43 11 II II NNP cord-300850-59j1m2tm 43 12 ) ) -RRB- cord-300850-59j1m2tm 43 13 , , , cord-300850-59j1m2tm 43 14 whereas whereas IN cord-300850-59j1m2tm 43 15 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 43 16 converts convert VBZ cord-300850-59j1m2tm 43 17 Ang Ang NNP cord-300850-59j1m2tm 43 18 II II NNP cord-300850-59j1m2tm 43 19 into into IN cord-300850-59j1m2tm 43 20 angiotensin angiotensin NN cord-300850-59j1m2tm 43 21 1 1 CD cord-300850-59j1m2tm 43 22 - - SYM cord-300850-59j1m2tm 43 23 7 7 CD cord-300850-59j1m2tm 44 1 ( ( -LRB- cord-300850-59j1m2tm 44 2 Ang Ang NNP cord-300850-59j1m2tm 44 3 1 1 CD cord-300850-59j1m2tm 44 4 - - SYM cord-300850-59j1m2tm 44 5 7 7 CD cord-300850-59j1m2tm 44 6 ) ) -RRB- cord-300850-59j1m2tm 44 7 or or CC cord-300850-59j1m2tm 44 8 angiotensin angiotensin NN cord-300850-59j1m2tm 44 9 1 1 CD cord-300850-59j1m2tm 44 10 - - SYM cord-300850-59j1m2tm 44 11 9 9 CD cord-300850-59j1m2tm 45 1 ( ( -LRB- cord-300850-59j1m2tm 45 2 Ang Ang NNP cord-300850-59j1m2tm 45 3 1 1 CD cord-300850-59j1m2tm 45 4 - - SYM cord-300850-59j1m2tm 45 5 9 9 CD cord-300850-59j1m2tm 45 6 ) ) -RRB- cord-300850-59j1m2tm 45 7 ( ( -LRB- cord-300850-59j1m2tm 45 8 12 12 CD cord-300850-59j1m2tm 45 9 ) ) -RRB- cord-300850-59j1m2tm 45 10 . . . cord-300850-59j1m2tm 46 1 Ang Ang NNP cord-300850-59j1m2tm 46 2 II II NNP cord-300850-59j1m2tm 46 3 and and CC cord-300850-59j1m2tm 46 4 Ang Ang NNP cord-300850-59j1m2tm 46 5 1 1 CD cord-300850-59j1m2tm 46 6 - - SYM cord-300850-59j1m2tm 46 7 7 7 CD cord-300850-59j1m2tm 46 8 have have VBP cord-300850-59j1m2tm 46 9 antagonizing antagonize VBG cord-300850-59j1m2tm 46 10 effects effect NNS cord-300850-59j1m2tm 46 11 , , , cord-300850-59j1m2tm 46 12 as as IN cord-300850-59j1m2tm 46 13 Ang Ang NNP cord-300850-59j1m2tm 46 14 II II NNP cord-300850-59j1m2tm 46 15 binds bind VBZ cord-300850-59j1m2tm 46 16 to to IN cord-300850-59j1m2tm 46 17 angiotensin angiotensin NN cord-300850-59j1m2tm 46 18 1 1 CD cord-300850-59j1m2tm 46 19 receptor receptor NN cord-300850-59j1m2tm 46 20 ( ( -LRB- cord-300850-59j1m2tm 46 21 AT1R AT1R NNP cord-300850-59j1m2tm 46 22 ) ) -RRB- cord-300850-59j1m2tm 46 23 , , , cord-300850-59j1m2tm 46 24 inducing induce VBG cord-300850-59j1m2tm 46 25 vasoconstriction vasoconstriction NN cord-300850-59j1m2tm 46 26 and and CC cord-300850-59j1m2tm 46 27 increase increase NN cord-300850-59j1m2tm 46 28 in in IN cord-300850-59j1m2tm 46 29 blood blood NN cord-300850-59j1m2tm 46 30 pressure pressure NN cord-300850-59j1m2tm 46 31 , , , cord-300850-59j1m2tm 46 32 whereas whereas IN cord-300850-59j1m2tm 46 33 Ang Ang NNP cord-300850-59j1m2tm 46 34 1 1 CD cord-300850-59j1m2tm 46 35 - - SYM cord-300850-59j1m2tm 46 36 7 7 CD cord-300850-59j1m2tm 46 37 binds bind VBZ cord-300850-59j1m2tm 46 38 to to IN cord-300850-59j1m2tm 46 39 AT2R AT2R NNP cord-300850-59j1m2tm 46 40 , , , cord-300850-59j1m2tm 46 41 leading lead VBG cord-300850-59j1m2tm 46 42 to to IN cord-300850-59j1m2tm 46 43 vasodilatation vasodilatation NN cord-300850-59j1m2tm 46 44 and and CC cord-300850-59j1m2tm 46 45 decrease decrease VB cord-300850-59j1m2tm 46 46 in in IN cord-300850-59j1m2tm 46 47 blood blood NN cord-300850-59j1m2tm 46 48 pressure pressure NN cord-300850-59j1m2tm 46 49 ( ( -LRB- cord-300850-59j1m2tm 46 50 11 11 CD cord-300850-59j1m2tm 46 51 , , , cord-300850-59j1m2tm 46 52 12 12 CD cord-300850-59j1m2tm 46 53 ) ) -RRB- cord-300850-59j1m2tm 46 54 . . . cord-300850-59j1m2tm 47 1 As as IN cord-300850-59j1m2tm 47 2 the the DT cord-300850-59j1m2tm 47 3 renin renin NN cord-300850-59j1m2tm 47 4 - - HYPH cord-300850-59j1m2tm 47 5 angiotensin angiotensin NN cord-300850-59j1m2tm 47 6 system system NN cord-300850-59j1m2tm 47 7 affects affect VBZ cord-300850-59j1m2tm 47 8 blood blood NN cord-300850-59j1m2tm 47 9 pressure pressure NN cord-300850-59j1m2tm 47 10 and and CC cord-300850-59j1m2tm 47 11 kidney kidney NN cord-300850-59j1m2tm 47 12 function function NN cord-300850-59j1m2tm 47 13 , , , cord-300850-59j1m2tm 47 14 ACE ACE NNP cord-300850-59j1m2tm 47 15 inhibitors inhibitor NNS cord-300850-59j1m2tm 47 16 and and CC cord-300850-59j1m2tm 47 17 AT1R AT1R NNS cord-300850-59j1m2tm 47 18 blockers blocker NNS cord-300850-59j1m2tm 47 19 are be VBP cord-300850-59j1m2tm 47 20 widely widely RB cord-300850-59j1m2tm 47 21 used use VBN cord-300850-59j1m2tm 47 22 in in IN cord-300850-59j1m2tm 47 23 hypertensive hypertensive JJ cord-300850-59j1m2tm 47 24 and and CC cord-300850-59j1m2tm 47 25 cardiac cardiac JJ cord-300850-59j1m2tm 47 26 patients patient NNS cord-300850-59j1m2tm 47 27 ( ( -LRB- cord-300850-59j1m2tm 47 28 13 13 CD cord-300850-59j1m2tm 47 29 ) ) -RRB- cord-300850-59j1m2tm 47 30 . . . cord-300850-59j1m2tm 48 1 In in IN cord-300850-59j1m2tm 48 2 this this DT cord-300850-59j1m2tm 48 3 context context NN cord-300850-59j1m2tm 48 4 , , , cord-300850-59j1m2tm 48 5 the the DT cord-300850-59j1m2tm 48 6 chronic chronic JJ cord-300850-59j1m2tm 48 7 use use NN cord-300850-59j1m2tm 48 8 of of IN cord-300850-59j1m2tm 48 9 ACE ace NN cord-300850-59j1m2tm 48 10 inhibitors inhibitor NNS cord-300850-59j1m2tm 48 11 or or CC cord-300850-59j1m2tm 48 12 AT1R at1r CD cord-300850-59j1m2tm 48 13 antagonists antagonist NNS cord-300850-59j1m2tm 48 14 may may MD cord-300850-59j1m2tm 48 15 be be VB cord-300850-59j1m2tm 48 16 of of IN cord-300850-59j1m2tm 48 17 particular particular JJ cord-300850-59j1m2tm 48 18 relevance relevance NN cord-300850-59j1m2tm 48 19 for for IN cord-300850-59j1m2tm 48 20 patients patient NNS cord-300850-59j1m2tm 48 21 infected infect VBN cord-300850-59j1m2tm 48 22 with with IN cord-300850-59j1m2tm 48 23 SARS SARS NNP cord-300850-59j1m2tm 48 24 - - HYPH cord-300850-59j1m2tm 48 25 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 48 26 , , , cord-300850-59j1m2tm 48 27 as as IN cord-300850-59j1m2tm 48 28 they -PRON- PRP cord-300850-59j1m2tm 48 29 may may MD cord-300850-59j1m2tm 48 30 alter alter VB cord-300850-59j1m2tm 48 31 the the DT cord-300850-59j1m2tm 48 32 dynamics dynamic NNS cord-300850-59j1m2tm 48 33 of of IN cord-300850-59j1m2tm 48 34 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 48 35 expression expression NN cord-300850-59j1m2tm 48 36 and and CC cord-300850-59j1m2tm 48 37 thus thus RB cord-300850-59j1m2tm 48 38 increase increase VB cord-300850-59j1m2tm 48 39 susceptibility susceptibility NN cord-300850-59j1m2tm 48 40 to to IN cord-300850-59j1m2tm 48 41 SARS SARS NNP cord-300850-59j1m2tm 48 42 - - HYPH cord-300850-59j1m2tm 48 43 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 48 44 infection infection NN cord-300850-59j1m2tm 48 45 . . . cord-300850-59j1m2tm 49 1 It -PRON- PRP cord-300850-59j1m2tm 49 2 has have VBZ cord-300850-59j1m2tm 49 3 already already RB cord-300850-59j1m2tm 49 4 been be VBN cord-300850-59j1m2tm 49 5 demonstrated demonstrate VBN cord-300850-59j1m2tm 49 6 by by IN cord-300850-59j1m2tm 49 7 using use VBG cord-300850-59j1m2tm 49 8 hypertensive hypertensive JJ cord-300850-59j1m2tm 49 9 rat rat NN cord-300850-59j1m2tm 49 10 models model NNS cord-300850-59j1m2tm 49 11 that that WDT cord-300850-59j1m2tm 49 12 AT1R AT1R NNP cord-300850-59j1m2tm 49 13 blockade blockade NN cord-300850-59j1m2tm 49 14 elevates elevate VBZ cord-300850-59j1m2tm 49 15 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 49 16 expression expression NN cord-300850-59j1m2tm 49 17 . . . cord-300850-59j1m2tm 50 1 Treatment treatment NN cord-300850-59j1m2tm 50 2 with with IN cord-300850-59j1m2tm 50 3 losartan losartan NNP cord-300850-59j1m2tm 50 4 and and CC cord-300850-59j1m2tm 50 5 lisinopril lisinopril NNP cord-300850-59j1m2tm 50 6 , , , cord-300850-59j1m2tm 50 7 either either CC cord-300850-59j1m2tm 50 8 alone alone RB cord-300850-59j1m2tm 50 9 or or CC cord-300850-59j1m2tm 50 10 in in IN cord-300850-59j1m2tm 50 11 combination combination NN cord-300850-59j1m2tm 50 12 , , , cord-300850-59j1m2tm 50 13 significantly significantly RB cord-300850-59j1m2tm 50 14 increases increase VBZ cord-300850-59j1m2tm 50 15 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 50 16 mRNA mrna NN cord-300850-59j1m2tm 50 17 in in IN cord-300850-59j1m2tm 50 18 cardiomyocytes cardiomyocyte NNS cord-300850-59j1m2tm 50 19 of of IN cord-300850-59j1m2tm 50 20 rats rat NNS cord-300850-59j1m2tm 50 21 . . . cord-300850-59j1m2tm 51 1 This this DT cord-300850-59j1m2tm 51 2 is be VBZ cord-300850-59j1m2tm 51 3 associated associate VBN cord-300850-59j1m2tm 51 4 with with IN cord-300850-59j1m2tm 51 5 higher high JJR cord-300850-59j1m2tm 51 6 Ang Ang NNP cord-300850-59j1m2tm 51 7 1 1 CD cord-300850-59j1m2tm 51 8 - - SYM cord-300850-59j1m2tm 51 9 7 7 CD cord-300850-59j1m2tm 51 10 plasma plasma NN cord-300850-59j1m2tm 51 11 concentrations concentration NNS cord-300850-59j1m2tm 51 12 ( ( -LRB- cord-300850-59j1m2tm 51 13 14 14 CD cord-300850-59j1m2tm 51 14 ) ) -RRB- cord-300850-59j1m2tm 51 15 . . . cord-300850-59j1m2tm 52 1 This this DT cord-300850-59j1m2tm 52 2 was be VBD cord-300850-59j1m2tm 52 3 corroborated corroborate VBN cord-300850-59j1m2tm 52 4 by by IN cord-300850-59j1m2tm 52 5 analyzing analyze VBG cord-300850-59j1m2tm 52 6 the the DT cord-300850-59j1m2tm 52 7 heart heart NN cord-300850-59j1m2tm 52 8 tissue tissue NN cord-300850-59j1m2tm 52 9 from from IN cord-300850-59j1m2tm 52 10 rats rat NNS cord-300850-59j1m2tm 52 11 with with IN cord-300850-59j1m2tm 52 12 myocardial myocardial JJ cord-300850-59j1m2tm 52 13 infarction infarction NN cord-300850-59j1m2tm 52 14 that that WDT cord-300850-59j1m2tm 52 15 were be VBD cord-300850-59j1m2tm 52 16 treated treat VBN cord-300850-59j1m2tm 52 17 with with IN cord-300850-59j1m2tm 52 18 losartan losartan NNP cord-300850-59j1m2tm 52 19 ( ( -LRB- cord-300850-59j1m2tm 52 20 15 15 CD cord-300850-59j1m2tm 52 21 ) ) -RRB- cord-300850-59j1m2tm 52 22 . . . cord-300850-59j1m2tm 53 1 Concordantly concordantly RB cord-300850-59j1m2tm 53 2 , , , cord-300850-59j1m2tm 53 3 olmesartan olmesartan NNP cord-300850-59j1m2tm 53 4 , , , cord-300850-59j1m2tm 53 5 a a DT cord-300850-59j1m2tm 53 6 more more RBR cord-300850-59j1m2tm 53 7 effective effective JJ cord-300850-59j1m2tm 53 8 AT1R at1r CD cord-300850-59j1m2tm 53 9 antagonist antagonist NN cord-300850-59j1m2tm 53 10 , , , cord-300850-59j1m2tm 53 11 significantly significantly RB cord-300850-59j1m2tm 53 12 increased increase VBD cord-300850-59j1m2tm 53 13 both both CC cord-300850-59j1m2tm 53 14 cardiac cardiac JJ cord-300850-59j1m2tm 53 15 and and CC cord-300850-59j1m2tm 53 16 renal renal JJ cord-300850-59j1m2tm 53 17 expression expression NN cord-300850-59j1m2tm 53 18 of of IN cord-300850-59j1m2tm 53 19 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 53 20 in in IN cord-300850-59j1m2tm 53 21 Wistar Wistar NNP cord-300850-59j1m2tm 53 22 - - HYPH cord-300850-59j1m2tm 53 23 Kyoto Kyoto NNP cord-300850-59j1m2tm 53 24 rats rat NNS cord-300850-59j1m2tm 53 25 ( ( -LRB- cord-300850-59j1m2tm 53 26 16 16 CD cord-300850-59j1m2tm 53 27 ) ) -RRB- cord-300850-59j1m2tm 53 28 . . . cord-300850-59j1m2tm 54 1 This this DT cord-300850-59j1m2tm 54 2 is be VBZ cord-300850-59j1m2tm 54 3 in in IN cord-300850-59j1m2tm 54 4 agreement agreement NN cord-300850-59j1m2tm 54 5 with with IN cord-300850-59j1m2tm 54 6 the the DT cord-300850-59j1m2tm 54 7 use use NN cord-300850-59j1m2tm 54 8 of of IN cord-300850-59j1m2tm 54 9 perindopril perindopril NN cord-300850-59j1m2tm 54 10 , , , cord-300850-59j1m2tm 54 11 an an DT cord-300850-59j1m2tm 54 12 ACE ace NN cord-300850-59j1m2tm 54 13 inhibitor inhibitor NN cord-300850-59j1m2tm 54 14 , , , cord-300850-59j1m2tm 54 15 in in IN cord-300850-59j1m2tm 54 16 rats rat NNS cord-300850-59j1m2tm 54 17 ( ( -LRB- cord-300850-59j1m2tm 54 18 17 17 CD cord-300850-59j1m2tm 54 19 ) ) -RRB- cord-300850-59j1m2tm 54 20 . . . cord-300850-59j1m2tm 55 1 Another another DT cord-300850-59j1m2tm 55 2 interesting interesting JJ cord-300850-59j1m2tm 55 3 feature feature NN cord-300850-59j1m2tm 55 4 of of IN cord-300850-59j1m2tm 55 5 the the DT cord-300850-59j1m2tm 55 6 dynamics dynamic NNS cord-300850-59j1m2tm 55 7 of of IN cord-300850-59j1m2tm 55 8 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 55 9 expression expression NN cord-300850-59j1m2tm 55 10 in in IN cord-300850-59j1m2tm 55 11 tissues tissue NNS cord-300850-59j1m2tm 55 12 is be VBZ cord-300850-59j1m2tm 55 13 its -PRON- PRP$ cord-300850-59j1m2tm 55 14 ability ability NN cord-300850-59j1m2tm 55 15 to to TO cord-300850-59j1m2tm 55 16 be be VB cord-300850-59j1m2tm 55 17 cleaved cleave VBN cord-300850-59j1m2tm 55 18 from from IN cord-300850-59j1m2tm 55 19 the the DT cord-300850-59j1m2tm 55 20 cell cell NN cord-300850-59j1m2tm 55 21 surface surface NN cord-300850-59j1m2tm 55 22 by by IN cord-300850-59j1m2tm 55 23 a a DT cord-300850-59j1m2tm 55 24 metalloproteinase metalloproteinase NN cord-300850-59j1m2tm 55 25 called call VBN cord-300850-59j1m2tm 55 26 ADAM17 adam17 NN cord-300850-59j1m2tm 55 27 ( ( -LRB- cord-300850-59j1m2tm 55 28 TACE tace NN cord-300850-59j1m2tm 55 29 ) ) -RRB- cord-300850-59j1m2tm 55 30 ( ( -LRB- cord-300850-59j1m2tm 55 31 18 18 CD cord-300850-59j1m2tm 55 32 ) ) -RRB- cord-300850-59j1m2tm 55 33 . . . cord-300850-59j1m2tm 56 1 The the DT cord-300850-59j1m2tm 56 2 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 56 3 ectodomain ectodomain NN cord-300850-59j1m2tm 56 4 gets get VBZ cord-300850-59j1m2tm 56 5 cleaved cleave VBN cord-300850-59j1m2tm 56 6 , , , cord-300850-59j1m2tm 56 7 releasing release VBG cord-300850-59j1m2tm 56 8 soluble soluble JJ cord-300850-59j1m2tm 56 9 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 56 10 ( ( -LRB- cord-300850-59j1m2tm 56 11 sACE-2 sace-2 CD cord-300850-59j1m2tm 56 12 ) ) -RRB- cord-300850-59j1m2tm 56 13 , , , cord-300850-59j1m2tm 56 14 whose whose WP$ cord-300850-59j1m2tm 56 15 role role NN cord-300850-59j1m2tm 56 16 has have VBZ cord-300850-59j1m2tm 56 17 not not RB cord-300850-59j1m2tm 56 18 been be VBN cord-300850-59j1m2tm 56 19 fully fully RB cord-300850-59j1m2tm 56 20 elucidated elucidate VBN cord-300850-59j1m2tm 56 21 . . . cord-300850-59j1m2tm 57 1 However however RB cord-300850-59j1m2tm 57 2 , , , cord-300850-59j1m2tm 57 3 it -PRON- PRP cord-300850-59j1m2tm 57 4 has have VBZ cord-300850-59j1m2tm 57 5 been be VBN cord-300850-59j1m2tm 57 6 shown show VBN cord-300850-59j1m2tm 57 7 that that IN cord-300850-59j1m2tm 57 8 a a DT cord-300850-59j1m2tm 57 9 higher high JJR cord-300850-59j1m2tm 57 10 concentration concentration NN cord-300850-59j1m2tm 57 11 of of IN cord-300850-59j1m2tm 57 12 sACE-2 sace-2 CD cord-300850-59j1m2tm 57 13 in in IN cord-300850-59j1m2tm 57 14 the the DT cord-300850-59j1m2tm 57 15 plasma plasma NN cord-300850-59j1m2tm 57 16 correlates correlate VBZ cord-300850-59j1m2tm 57 17 with with IN cord-300850-59j1m2tm 57 18 a a DT cord-300850-59j1m2tm 57 19 poorer poor JJR cord-300850-59j1m2tm 57 20 prognosis prognosis NN cord-300850-59j1m2tm 57 21 after after IN cord-300850-59j1m2tm 57 22 heart heart NN cord-300850-59j1m2tm 57 23 failure failure NN cord-300850-59j1m2tm 57 24 ( ( -LRB- cord-300850-59j1m2tm 57 25 19 19 CD cord-300850-59j1m2tm 57 26 ) ) -RRB- cord-300850-59j1m2tm 57 27 . . . cord-300850-59j1m2tm 58 1 Notably notably RB cord-300850-59j1m2tm 58 2 , , , cord-300850-59j1m2tm 58 3 sACE-2 sace-2 PRP cord-300850-59j1m2tm 58 4 may may MD cord-300850-59j1m2tm 58 5 also also RB cord-300850-59j1m2tm 58 6 be be VB cord-300850-59j1m2tm 58 7 detected detect VBN cord-300850-59j1m2tm 58 8 at at IN cord-300850-59j1m2tm 58 9 higher high JJR cord-300850-59j1m2tm 58 10 concentrations concentration NNS cord-300850-59j1m2tm 58 11 in in IN cord-300850-59j1m2tm 58 12 the the DT cord-300850-59j1m2tm 58 13 cerebrospinal cerebrospinal JJ cord-300850-59j1m2tm 58 14 fluid fluid NN cord-300850-59j1m2tm 58 15 in in IN cord-300850-59j1m2tm 58 16 hypertensive hypertensive JJ cord-300850-59j1m2tm 58 17 patients patient NNS cord-300850-59j1m2tm 58 18 . . . cord-300850-59j1m2tm 59 1 This this DT cord-300850-59j1m2tm 59 2 has have VBZ cord-300850-59j1m2tm 59 3 been be VBN cord-300850-59j1m2tm 59 4 corroborated corroborate VBN cord-300850-59j1m2tm 59 5 in in IN cord-300850-59j1m2tm 59 6 Nefh Nefh NNP cord-300850-59j1m2tm 59 7 cre cre NNP cord-300850-59j1m2tm 60 1 x x LS cord-300850-59j1m2tm 60 2 AT1aR AT1aR NNP cord-300850-59j1m2tm 60 3 flox flox NNP cord-300850-59j1m2tm 60 4 / / SYM cord-300850-59j1m2tm 60 5 flox flox NNP cord-300850-59j1m2tm 60 6 mice mouse NNS cord-300850-59j1m2tm 60 7 , , , cord-300850-59j1m2tm 60 8 indicating indicate VBG cord-300850-59j1m2tm 60 9 that that IN cord-300850-59j1m2tm 60 10 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 60 11 and and CC cord-300850-59j1m2tm 60 12 sACE-2 sace-2 CD cord-300850-59j1m2tm 60 13 levels level NNS cord-300850-59j1m2tm 60 14 in in IN cord-300850-59j1m2tm 60 15 the the DT cord-300850-59j1m2tm 60 16 brain brain NN cord-300850-59j1m2tm 60 17 are be VBP cord-300850-59j1m2tm 60 18 associated associate VBN cord-300850-59j1m2tm 60 19 with with IN cord-300850-59j1m2tm 60 20 the the DT cord-300850-59j1m2tm 60 21 etiology etiology NN cord-300850-59j1m2tm 60 22 of of IN cord-300850-59j1m2tm 60 23 neurogenic neurogenic JJ cord-300850-59j1m2tm 60 24 hypertension hypertension NN cord-300850-59j1m2tm 60 25 ( ( -LRB- cord-300850-59j1m2tm 60 26 20 20 CD cord-300850-59j1m2tm 60 27 ) ) -RRB- cord-300850-59j1m2tm 60 28 . . . cord-300850-59j1m2tm 61 1 Further further RB cord-300850-59j1m2tm 61 2 , , , cord-300850-59j1m2tm 61 3 it -PRON- PRP cord-300850-59j1m2tm 61 4 was be VBD cord-300850-59j1m2tm 61 5 demonstrated demonstrate VBN cord-300850-59j1m2tm 61 6 that that IN cord-300850-59j1m2tm 61 7 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 61 8 may may MD cord-300850-59j1m2tm 61 9 be be VB cord-300850-59j1m2tm 61 10 cleaved cleave VBN cord-300850-59j1m2tm 61 11 by by IN cord-300850-59j1m2tm 61 12 other other JJ cord-300850-59j1m2tm 61 13 mechanisms mechanism NNS cord-300850-59j1m2tm 61 14 . . . cord-300850-59j1m2tm 62 1 For for IN cord-300850-59j1m2tm 62 2 instance instance NN cord-300850-59j1m2tm 62 3 , , , cord-300850-59j1m2tm 62 4 the the DT cord-300850-59j1m2tm 62 5 SARS SARS NNP cord-300850-59j1m2tm 62 6 spike spike NN cord-300850-59j1m2tm 62 7 protein protein NN cord-300850-59j1m2tm 62 8 may may MD cord-300850-59j1m2tm 62 9 modulate modulate VB cord-300850-59j1m2tm 62 10 ADAM17 ADAM17 NNP cord-300850-59j1m2tm 62 11 expression expression NN cord-300850-59j1m2tm 62 12 , , , cord-300850-59j1m2tm 62 13 which which WDT cord-300850-59j1m2tm 62 14 in in IN cord-300850-59j1m2tm 62 15 turn turn NN cord-300850-59j1m2tm 62 16 cleaves cleave VBZ cord-300850-59j1m2tm 62 17 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 62 18 into into IN cord-300850-59j1m2tm 62 19 its -PRON- PRP$ cord-300850-59j1m2tm 62 20 soluble soluble JJ cord-300850-59j1m2tm 62 21 form form NN cord-300850-59j1m2tm 62 22 . . . cord-300850-59j1m2tm 63 1 This this DT cord-300850-59j1m2tm 63 2 was be VBD cord-300850-59j1m2tm 63 3 found find VBN cord-300850-59j1m2tm 63 4 to to TO cord-300850-59j1m2tm 63 5 be be VB cord-300850-59j1m2tm 63 6 dependent dependent JJ cord-300850-59j1m2tm 63 7 on on IN cord-300850-59j1m2tm 63 8 the the DT cord-300850-59j1m2tm 63 9 cytoplasmic cytoplasmic JJ cord-300850-59j1m2tm 63 10 domain domain NN cord-300850-59j1m2tm 63 11 of of IN cord-300850-59j1m2tm 63 12 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 63 13 , , , cord-300850-59j1m2tm 63 14 as as IN cord-300850-59j1m2tm 63 15 siRNA siRNA NNP cord-300850-59j1m2tm 63 16 against against IN cord-300850-59j1m2tm 63 17 ADAM17 ADAM17 NNP cord-300850-59j1m2tm 63 18 or or CC cord-300850-59j1m2tm 64 1 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 64 2 lacking lack VBG cord-300850-59j1m2tm 64 3 intracellular intracellular JJ cord-300850-59j1m2tm 64 4 domains domain NNS cord-300850-59j1m2tm 64 5 abrogated abrogate VBD cord-300850-59j1m2tm 64 6 this this DT cord-300850-59j1m2tm 64 7 phenomenon phenomenon NN cord-300850-59j1m2tm 64 8 ( ( -LRB- cord-300850-59j1m2tm 64 9 21 21 CD cord-300850-59j1m2tm 64 10 ) ) -RRB- cord-300850-59j1m2tm 64 11 . . . cord-300850-59j1m2tm 65 1 Interestingly interestingly RB cord-300850-59j1m2tm 65 2 , , , cord-300850-59j1m2tm 65 3 increased increase VBN cord-300850-59j1m2tm 65 4 shedding shedding NN cord-300850-59j1m2tm 65 5 of of IN cord-300850-59j1m2tm 65 6 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 65 7 correlates correlate VBZ cord-300850-59j1m2tm 65 8 with with IN cord-300850-59j1m2tm 65 9 worsening worsen VBG cord-300850-59j1m2tm 65 10 of of IN cord-300850-59j1m2tm 65 11 the the DT cord-300850-59j1m2tm 65 12 disease disease NN cord-300850-59j1m2tm 65 13 , , , cord-300850-59j1m2tm 65 14 probably probably RB cord-300850-59j1m2tm 65 15 because because IN cord-300850-59j1m2tm 65 16 of of IN cord-300850-59j1m2tm 65 17 an an DT cord-300850-59j1m2tm 65 18 increase increase NN cord-300850-59j1m2tm 65 19 in in IN cord-300850-59j1m2tm 65 20 Ang Ang NNP cord-300850-59j1m2tm 65 21 II II NNP cord-300850-59j1m2tm 65 22 instead instead RB cord-300850-59j1m2tm 65 23 of of IN cord-300850-59j1m2tm 65 24 Ang Ang NNP cord-300850-59j1m2tm 65 25 1 1 CD cord-300850-59j1m2tm 65 26 - - SYM cord-300850-59j1m2tm 65 27 7 7 CD cord-300850-59j1m2tm 65 28 . . . cord-300850-59j1m2tm 66 1 This this DT cord-300850-59j1m2tm 66 2 leads lead VBZ cord-300850-59j1m2tm 66 3 to to IN cord-300850-59j1m2tm 66 4 increased increase VBN cord-300850-59j1m2tm 66 5 vascular vascular JJ cord-300850-59j1m2tm 66 6 permeability permeability NN cord-300850-59j1m2tm 66 7 and and CC cord-300850-59j1m2tm 66 8 local local JJ cord-300850-59j1m2tm 66 9 inflammation inflammation NN cord-300850-59j1m2tm 66 10 . . . cord-300850-59j1m2tm 67 1 Interestingly interestingly RB cord-300850-59j1m2tm 67 2 , , , cord-300850-59j1m2tm 67 3 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 67 4 cleavage cleavage NN cord-300850-59j1m2tm 67 5 from from IN cord-300850-59j1m2tm 67 6 the the DT cord-300850-59j1m2tm 67 7 cell cell NN cord-300850-59j1m2tm 67 8 surface surface NN cord-300850-59j1m2tm 67 9 may may MD cord-300850-59j1m2tm 67 10 also also RB cord-300850-59j1m2tm 67 11 occur occur VB cord-300850-59j1m2tm 67 12 in in IN cord-300850-59j1m2tm 67 13 lung lung NN cord-300850-59j1m2tm 67 14 epithelial epithelial JJ cord-300850-59j1m2tm 67 15 cells cell NNS cord-300850-59j1m2tm 67 16 ( ( -LRB- cord-300850-59j1m2tm 67 17 22 22 CD cord-300850-59j1m2tm 67 18 ) ) -RRB- cord-300850-59j1m2tm 67 19 . . . cord-300850-59j1m2tm 68 1 Thus thus RB cord-300850-59j1m2tm 68 2 , , , cord-300850-59j1m2tm 68 3 cleavage cleavage NN cord-300850-59j1m2tm 68 4 of of IN cord-300850-59j1m2tm 68 5 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 68 6 into into IN cord-300850-59j1m2tm 68 7 sACE-2 sace-2 PRP cord-300850-59j1m2tm 68 8 would would MD cord-300850-59j1m2tm 68 9 compromise compromise VB cord-300850-59j1m2tm 68 10 the the DT cord-300850-59j1m2tm 68 11 effect effect NN cord-300850-59j1m2tm 68 12 of of IN cord-300850-59j1m2tm 68 13 Ang Ang NNP cord-300850-59j1m2tm 68 14 1 1 CD cord-300850-59j1m2tm 68 15 - - SYM cord-300850-59j1m2tm 68 16 7 7 CD cord-300850-59j1m2tm 68 17 on on IN cord-300850-59j1m2tm 68 18 AT2R AT2R NNS cord-300850-59j1m2tm 68 19 , , , cord-300850-59j1m2tm 68 20 thereby thereby RB cord-300850-59j1m2tm 68 21 reducing reduce VBG cord-300850-59j1m2tm 68 22 pulmonary pulmonary JJ cord-300850-59j1m2tm 68 23 hypertension hypertension NN cord-300850-59j1m2tm 68 24 and and CC cord-300850-59j1m2tm 68 25 inflammation inflammation NN cord-300850-59j1m2tm 68 26 . . . cord-300850-59j1m2tm 69 1 Altogether altogether RB cord-300850-59j1m2tm 69 2 , , , cord-300850-59j1m2tm 69 3 as as IN cord-300850-59j1m2tm 69 4 depicted depict VBN cord-300850-59j1m2tm 69 5 in in IN cord-300850-59j1m2tm 69 6 Figure figure NN cord-300850-59j1m2tm 69 7 1 1 CD cord-300850-59j1m2tm 69 8 , , , cord-300850-59j1m2tm 69 9 these these DT cord-300850-59j1m2tm 69 10 data datum NNS cord-300850-59j1m2tm 69 11 show show VBP cord-300850-59j1m2tm 69 12 that that IN cord-300850-59j1m2tm 69 13 modulating modulate VBG cord-300850-59j1m2tm 69 14 the the DT cord-300850-59j1m2tm 69 15 renin renin NN cord-300850-59j1m2tm 69 16 - - HYPH cord-300850-59j1m2tm 69 17 angiotensin angiotensin NN cord-300850-59j1m2tm 69 18 axis axis NN cord-300850-59j1m2tm 69 19 alters alter VBZ cord-300850-59j1m2tm 69 20 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 69 21 expression expression NN cord-300850-59j1m2tm 69 22 in in IN cord-300850-59j1m2tm 69 23 several several JJ cord-300850-59j1m2tm 69 24 tissues tissue NNS cord-300850-59j1m2tm 69 25 , , , cord-300850-59j1m2tm 69 26 especially especially RB cord-300850-59j1m2tm 69 27 in in IN cord-300850-59j1m2tm 69 28 the the DT cord-300850-59j1m2tm 69 29 lung lung NN cord-300850-59j1m2tm 69 30 and and CC cord-300850-59j1m2tm 69 31 heart heart NN cord-300850-59j1m2tm 69 32 tissues tissue NNS cord-300850-59j1m2tm 69 33 . . . cord-300850-59j1m2tm 70 1 The the DT cord-300850-59j1m2tm 70 2 use use NN cord-300850-59j1m2tm 70 3 of of IN cord-300850-59j1m2tm 70 4 ACE ace NN cord-300850-59j1m2tm 70 5 inhibitors inhibitor NNS cord-300850-59j1m2tm 70 6 and and CC cord-300850-59j1m2tm 70 7 AT1R at1r CD cord-300850-59j1m2tm 70 8 antagonists antagonist NNS cord-300850-59j1m2tm 70 9 seems seem VBZ cord-300850-59j1m2tm 70 10 to to TO cord-300850-59j1m2tm 70 11 upregulate upregulate VB cord-300850-59j1m2tm 70 12 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 70 13 expression expression NN cord-300850-59j1m2tm 70 14 , , , cord-300850-59j1m2tm 70 15 facilitating facilitate VBG cord-300850-59j1m2tm 70 16 viral viral JJ cord-300850-59j1m2tm 70 17 attachment attachment NN cord-300850-59j1m2tm 70 18 and and CC cord-300850-59j1m2tm 70 19 entry entry NN cord-300850-59j1m2tm 70 20 . . . cord-300850-59j1m2tm 71 1 The the DT cord-300850-59j1m2tm 71 2 further further JJ cord-300850-59j1m2tm 71 3 presence presence NN cord-300850-59j1m2tm 71 4 of of IN cord-300850-59j1m2tm 71 5 the the DT cord-300850-59j1m2tm 71 6 virus virus NN cord-300850-59j1m2tm 71 7 itself -PRON- PRP cord-300850-59j1m2tm 71 8 or or CC cord-300850-59j1m2tm 71 9 some some DT cord-300850-59j1m2tm 71 10 cytokines cytokine NNS cord-300850-59j1m2tm 71 11 , , , cord-300850-59j1m2tm 71 12 including include VBG cord-300850-59j1m2tm 71 13 TNF TNF NNP cord-300850-59j1m2tm 71 14 - - HYPH cord-300850-59j1m2tm 71 15 a a NNP cord-300850-59j1m2tm 71 16 , , , cord-300850-59j1m2tm 71 17 leads lead VBZ cord-300850-59j1m2tm 71 18 to to IN cord-300850-59j1m2tm 71 19 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 71 20 release release NN cord-300850-59j1m2tm 71 21 from from IN cord-300850-59j1m2tm 71 22 the the DT cord-300850-59j1m2tm 71 23 cell cell NN cord-300850-59j1m2tm 71 24 membrane membrane NN cord-300850-59j1m2tm 71 25 , , , cord-300850-59j1m2tm 71 26 abrogating abrogate VBG cord-300850-59j1m2tm 71 27 its -PRON- PRP$ cord-300850-59j1m2tm 71 28 function function NN cord-300850-59j1m2tm 71 29 to to TO cord-300850-59j1m2tm 71 30 counteract counteract VB cord-300850-59j1m2tm 71 31 Ang Ang NNP cord-300850-59j1m2tm 71 32 II II NNP cord-300850-59j1m2tm 71 33 . . . cord-300850-59j1m2tm 72 1 Altogether altogether RB cord-300850-59j1m2tm 72 2 , , , cord-300850-59j1m2tm 72 3 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 72 4 overexpression overexpression NN cord-300850-59j1m2tm 72 5 may may MD cord-300850-59j1m2tm 72 6 facilitate facilitate VB cord-300850-59j1m2tm 72 7 viral viral JJ cord-300850-59j1m2tm 72 8 replication replication NN cord-300850-59j1m2tm 72 9 in in IN cord-300850-59j1m2tm 72 10 lung lung NN cord-300850-59j1m2tm 72 11 tissue tissue NN cord-300850-59j1m2tm 72 12 and and CC cord-300850-59j1m2tm 72 13 promote promote VB cord-300850-59j1m2tm 72 14 lung lung NN cord-300850-59j1m2tm 72 15 vascular vascular JJ cord-300850-59j1m2tm 72 16 permeability permeability NN cord-300850-59j1m2tm 72 17 , , , cord-300850-59j1m2tm 72 18 a a DT cord-300850-59j1m2tm 72 19 common common JJ cord-300850-59j1m2tm 72 20 feature feature NN cord-300850-59j1m2tm 72 21 of of IN cord-300850-59j1m2tm 72 22 severe severe JJ cord-300850-59j1m2tm 72 23 SARS SARS NNP cord-300850-59j1m2tm 72 24 - - HYPH cord-300850-59j1m2tm 72 25 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 72 26 infection infection NN cord-300850-59j1m2tm 72 27 . . . cord-300850-59j1m2tm 73 1 In in IN cord-300850-59j1m2tm 73 2 summary summary NN cord-300850-59j1m2tm 73 3 , , , cord-300850-59j1m2tm 73 4 this this DT cord-300850-59j1m2tm 73 5 may may MD cord-300850-59j1m2tm 73 6 greatly greatly RB cord-300850-59j1m2tm 73 7 impact impact VB cord-300850-59j1m2tm 73 8 the the DT cord-300850-59j1m2tm 73 9 outcome outcome NN cord-300850-59j1m2tm 73 10 of of IN cord-300850-59j1m2tm 73 11 SARS SARS NNP cord-300850-59j1m2tm 73 12 - - HYPH cord-300850-59j1m2tm 73 13 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 73 14 infection infection NN cord-300850-59j1m2tm 73 15 in in IN cord-300850-59j1m2tm 73 16 elderly elderly JJ cord-300850-59j1m2tm 73 17 and and CC cord-300850-59j1m2tm 73 18 hypertensive hypertensive JJ cord-300850-59j1m2tm 73 19 patients patient NNS cord-300850-59j1m2tm 73 20 , , , cord-300850-59j1m2tm 73 21 as as IN cord-300850-59j1m2tm 73 22 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 73 23 is be VBZ cord-300850-59j1m2tm 73 24 the the DT cord-300850-59j1m2tm 73 25 putative putative JJ cord-300850-59j1m2tm 73 26 attachment attachment NN cord-300850-59j1m2tm 73 27 and and CC cord-300850-59j1m2tm 73 28 invasion invasion NN cord-300850-59j1m2tm 73 29 receptor receptor NN cord-300850-59j1m2tm 73 30 for for IN cord-300850-59j1m2tm 73 31 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 73 32 ( ( -LRB- cord-300850-59j1m2tm 73 33 8 8 CD cord-300850-59j1m2tm 73 34 , , , cord-300850-59j1m2tm 73 35 23 23 CD cord-300850-59j1m2tm 73 36 ) ) -RRB- cord-300850-59j1m2tm 73 37 . . . cord-300850-59j1m2tm 74 1 In in IN cord-300850-59j1m2tm 74 2 fact fact NN cord-300850-59j1m2tm 74 3 , , , cord-300850-59j1m2tm 74 4 the the DT cord-300850-59j1m2tm 74 5 use use NN cord-300850-59j1m2tm 74 6 of of IN cord-300850-59j1m2tm 74 7 TACE TACE NNP cord-300850-59j1m2tm 74 8 inhibitors inhibitor NNS cord-300850-59j1m2tm 74 9 as as IN cord-300850-59j1m2tm 74 10 SARS SARS NNP cord-300850-59j1m2tm 74 11 antiviral antiviral JJ cord-300850-59j1m2tm 74 12 agents agent NNS cord-300850-59j1m2tm 74 13 has have VBZ cord-300850-59j1m2tm 74 14 already already RB cord-300850-59j1m2tm 74 15 been be VBN cord-300850-59j1m2tm 74 16 proposed propose VBN cord-300850-59j1m2tm 74 17 in in IN cord-300850-59j1m2tm 74 18 experimental experimental JJ cord-300850-59j1m2tm 74 19 models model NNS cord-300850-59j1m2tm 74 20 ( ( -LRB- cord-300850-59j1m2tm 74 21 2 2 CD cord-300850-59j1m2tm 74 22 , , , cord-300850-59j1m2tm 74 23 3 3 CD cord-300850-59j1m2tm 74 24 , , , cord-300850-59j1m2tm 74 25 24 24 CD cord-300850-59j1m2tm 74 26 ) ) -RRB- cord-300850-59j1m2tm 74 27 . . . cord-300850-59j1m2tm 74 28 ' ' '' cord-300850-59j1m2tm 75 1 ANTIBODY antibody NN cord-300850-59j1m2tm 75 2 - - HYPH cord-300850-59j1m2tm 75 3 DEPENDENT dependent JJ cord-300850-59j1m2tm 75 4 ENHANCEMENT enhancement NN cord-300850-59j1m2tm 76 1 ADE ADE NNP cord-300850-59j1m2tm 76 2 is be VBZ cord-300850-59j1m2tm 76 3 a a DT cord-300850-59j1m2tm 76 4 phenomenon phenomenon NN cord-300850-59j1m2tm 76 5 by by IN cord-300850-59j1m2tm 76 6 which which WDT cord-300850-59j1m2tm 76 7 viruses virus NNS cord-300850-59j1m2tm 76 8 use use VBP cord-300850-59j1m2tm 76 9 preexisting preexist VBG cord-300850-59j1m2tm 76 10 non non JJ cord-300850-59j1m2tm 76 11 - - JJ cord-300850-59j1m2tm 76 12 neutralizing neutralize VBG cord-300850-59j1m2tm 76 13 antibodies antibody NNS cord-300850-59j1m2tm 76 14 from from IN cord-300850-59j1m2tm 76 15 previous previous JJ cord-300850-59j1m2tm 76 16 exposure exposure NN cord-300850-59j1m2tm 76 17 to to TO cord-300850-59j1m2tm 76 18 invade invade VB cord-300850-59j1m2tm 76 19 host host NN cord-300850-59j1m2tm 76 20 cells cell NNS cord-300850-59j1m2tm 76 21 through through IN cord-300850-59j1m2tm 76 22 Fc Fc NNP cord-300850-59j1m2tm 76 23 receptor receptor NN cord-300850-59j1m2tm 76 24 - - HYPH cord-300850-59j1m2tm 76 25 mediated mediate VBN cord-300850-59j1m2tm 76 26 internalization internalization NN cord-300850-59j1m2tm 76 27 . . . cord-300850-59j1m2tm 77 1 This this DT cord-300850-59j1m2tm 77 2 is be VBZ cord-300850-59j1m2tm 77 3 most most RBS cord-300850-59j1m2tm 77 4 commonly commonly RB cord-300850-59j1m2tm 77 5 observed observe VBN cord-300850-59j1m2tm 77 6 during during IN cord-300850-59j1m2tm 77 7 secondary secondary JJ cord-300850-59j1m2tm 77 8 dengue dengue NN cord-300850-59j1m2tm 77 9 virus virus NN cord-300850-59j1m2tm 77 10 ( ( -LRB- cord-300850-59j1m2tm 77 11 DENV DENV NNP cord-300850-59j1m2tm 77 12 ) ) -RRB- cord-300850-59j1m2tm 77 13 infection infection NN cord-300850-59j1m2tm 77 14 , , , cord-300850-59j1m2tm 77 15 causing cause VBG cord-300850-59j1m2tm 77 16 severe severe JJ cord-300850-59j1m2tm 77 17 hemorrhagic hemorrhagic JJ cord-300850-59j1m2tm 77 18 disease disease NN cord-300850-59j1m2tm 77 19 ( ( -LRB- cord-300850-59j1m2tm 77 20 25 25 CD cord-300850-59j1m2tm 77 21 ) ) -RRB- cord-300850-59j1m2tm 77 22 . . . cord-300850-59j1m2tm 78 1 Notably notably RB cord-300850-59j1m2tm 78 2 , , , cord-300850-59j1m2tm 78 3 the the DT cord-300850-59j1m2tm 78 4 possibility possibility NN cord-300850-59j1m2tm 78 5 of of IN cord-300850-59j1m2tm 78 6 ADE ADE NNP cord-300850-59j1m2tm 78 7 between between IN cord-300850-59j1m2tm 78 8 Zika Zika NNP cord-300850-59j1m2tm 78 9 virus virus NN cord-300850-59j1m2tm 78 10 ( ( -LRB- cord-300850-59j1m2tm 78 11 ZIKV ZIKV NNP cord-300850-59j1m2tm 78 12 ) ) -RRB- cord-300850-59j1m2tm 78 13 , , , cord-300850-59j1m2tm 78 14 the the DT cord-300850-59j1m2tm 78 15 causative causative JJ cord-300850-59j1m2tm 78 16 agent agent NN cord-300850-59j1m2tm 78 17 of of IN cord-300850-59j1m2tm 78 18 ZIKV ZIKV NNP cord-300850-59j1m2tm 78 19 congenital congenital JJ cord-300850-59j1m2tm 78 20 syndrome syndrome NN cord-300850-59j1m2tm 78 21 ( ( -LRB- cord-300850-59j1m2tm 78 22 26 26 CD cord-300850-59j1m2tm 78 23 ) ) -RRB- cord-300850-59j1m2tm 78 24 , , , cord-300850-59j1m2tm 78 25 and and CC cord-300850-59j1m2tm 78 26 DENV DENV NNP cord-300850-59j1m2tm 78 27 has have VBZ cord-300850-59j1m2tm 78 28 been be VBN cord-300850-59j1m2tm 78 29 intensely intensely RB cord-300850-59j1m2tm 78 30 debated debate VBN cord-300850-59j1m2tm 78 31 recently recently RB cord-300850-59j1m2tm 78 32 ( ( -LRB- cord-300850-59j1m2tm 78 33 27 27 CD cord-300850-59j1m2tm 78 34 ) ) -RRB- cord-300850-59j1m2tm 78 35 ( ( -LRB- cord-300850-59j1m2tm 78 36 28 28 CD cord-300850-59j1m2tm 78 37 ) ) -RRB- cord-300850-59j1m2tm 78 38 ( ( -LRB- cord-300850-59j1m2tm 78 39 29 29 CD cord-300850-59j1m2tm 78 40 ) ) -RRB- cord-300850-59j1m2tm 78 41 . . . cord-300850-59j1m2tm 79 1 Moreover moreover RB cord-300850-59j1m2tm 79 2 , , , cord-300850-59j1m2tm 79 3 ADE ADE NNP cord-300850-59j1m2tm 79 4 has have VBZ cord-300850-59j1m2tm 79 5 been be VBN cord-300850-59j1m2tm 79 6 the the DT cord-300850-59j1m2tm 79 7 focus focus NN cord-300850-59j1m2tm 79 8 of of IN cord-300850-59j1m2tm 79 9 debate debate NN cord-300850-59j1m2tm 79 10 for for IN cord-300850-59j1m2tm 79 11 Ebola Ebola NNP cord-300850-59j1m2tm 79 12 ( ( -LRB- cord-300850-59j1m2tm 79 13 30 30 CD cord-300850-59j1m2tm 79 14 ) ) -RRB- cord-300850-59j1m2tm 79 15 and and CC cord-300850-59j1m2tm 79 16 HIV HIV NNP cord-300850-59j1m2tm 79 17 ( ( -LRB- cord-300850-59j1m2tm 79 18 31 31 CD cord-300850-59j1m2tm 79 19 ) ) -RRB- cord-300850-59j1m2tm 79 20 infections infection NNS cord-300850-59j1m2tm 79 21 . . . cord-300850-59j1m2tm 80 1 During during IN cord-300850-59j1m2tm 80 2 ADE ADE NNP cord-300850-59j1m2tm 80 3 , , , cord-300850-59j1m2tm 80 4 preexisting preexist VBG cord-300850-59j1m2tm 80 5 antibodies antibody NNS cord-300850-59j1m2tm 80 6 elicited elicit VBN cord-300850-59j1m2tm 80 7 during during IN cord-300850-59j1m2tm 80 8 a a DT cord-300850-59j1m2tm 80 9 previous previous JJ cord-300850-59j1m2tm 80 10 viral viral JJ cord-300850-59j1m2tm 80 11 exposure exposure NN cord-300850-59j1m2tm 80 12 are be VBP cord-300850-59j1m2tm 80 13 not not RB cord-300850-59j1m2tm 80 14 able able JJ cord-300850-59j1m2tm 80 15 to to TO cord-300850-59j1m2tm 80 16 neutralize neutralize VB cord-300850-59j1m2tm 80 17 viral viral JJ cord-300850-59j1m2tm 80 18 particles particle NNS cord-300850-59j1m2tm 80 19 during during IN cord-300850-59j1m2tm 80 20 a a DT cord-300850-59j1m2tm 80 21 secondary secondary JJ cord-300850-59j1m2tm 80 22 infection infection NN cord-300850-59j1m2tm 80 23 with with IN cord-300850-59j1m2tm 80 24 any any DT cord-300850-59j1m2tm 80 25 antigenicrelated antigenicrelated JJ cord-300850-59j1m2tm 80 26 virus virus NN cord-300850-59j1m2tm 80 27 . . . cord-300850-59j1m2tm 81 1 Instead instead RB cord-300850-59j1m2tm 81 2 , , , cord-300850-59j1m2tm 81 3 IgG igg NN cord-300850-59j1m2tm 81 4 - - HYPH cord-300850-59j1m2tm 81 5 opsonized opsonize VBN cord-300850-59j1m2tm 81 6 viral viral JJ cord-300850-59j1m2tm 81 7 particles particle NNS cord-300850-59j1m2tm 81 8 then then RB cord-300850-59j1m2tm 81 9 target target VB cord-300850-59j1m2tm 81 10 FcgR FcgR NNP cord-300850-59j1m2tm 81 11 expressed express VBD cord-300850-59j1m2tm 81 12 on on IN cord-300850-59j1m2tm 81 13 endothelial endothelial JJ cord-300850-59j1m2tm 81 14 and and CC cord-300850-59j1m2tm 81 15 immune immune JJ cord-300850-59j1m2tm 81 16 cells cell NNS cord-300850-59j1m2tm 81 17 , , , cord-300850-59j1m2tm 81 18 facilitating facilitate VBG cord-300850-59j1m2tm 81 19 viral viral JJ cord-300850-59j1m2tm 81 20 internalization internalization NN cord-300850-59j1m2tm 81 21 into into IN cord-300850-59j1m2tm 81 22 host host NN cord-300850-59j1m2tm 81 23 cells cell NNS cord-300850-59j1m2tm 81 24 . . . cord-300850-59j1m2tm 82 1 Further further RB cord-300850-59j1m2tm 82 2 , , , cord-300850-59j1m2tm 82 3 after after IN cord-300850-59j1m2tm 82 4 intense intense JJ cord-300850-59j1m2tm 82 5 viral viral JJ cord-300850-59j1m2tm 82 6 replication replication NN cord-300850-59j1m2tm 82 7 , , , cord-300850-59j1m2tm 82 8 endothelial endothelial JJ cord-300850-59j1m2tm 82 9 cells cell NNS cord-300850-59j1m2tm 82 10 may may MD cord-300850-59j1m2tm 82 11 respond respond VB cord-300850-59j1m2tm 82 12 by by IN cord-300850-59j1m2tm 82 13 increasing increase VBG cord-300850-59j1m2tm 82 14 vascular vascular JJ cord-300850-59j1m2tm 82 15 permeability permeability NN cord-300850-59j1m2tm 82 16 and and CC cord-300850-59j1m2tm 82 17 allowing allow VBG cord-300850-59j1m2tm 82 18 exudate exudate NN cord-300850-59j1m2tm 82 19 extravasation extravasation NN cord-300850-59j1m2tm 82 20 and and CC cord-300850-59j1m2tm 82 21 bleeding bleed VBG cord-300850-59j1m2tm 82 22 . . . cord-300850-59j1m2tm 83 1 However however RB cord-300850-59j1m2tm 83 2 , , , cord-300850-59j1m2tm 83 3 monocytes monocyte NNS cord-300850-59j1m2tm 83 4 become become VBN cord-300850-59j1m2tm 83 5 highly highly RB cord-300850-59j1m2tm 83 6 activated activate VBN cord-300850-59j1m2tm 83 7 and and CC cord-300850-59j1m2tm 83 8 may may MD cord-300850-59j1m2tm 83 9 initiate initiate VB cord-300850-59j1m2tm 83 10 a a DT cord-300850-59j1m2tm 83 11 cytokine cytokine NN cord-300850-59j1m2tm 83 12 storm storm NN cord-300850-59j1m2tm 83 13 ( ( -LRB- cord-300850-59j1m2tm 83 14 32 32 CD cord-300850-59j1m2tm 83 15 ) ) -RRB- cord-300850-59j1m2tm 83 16 . . . cord-300850-59j1m2tm 84 1 In in IN cord-300850-59j1m2tm 84 2 the the DT cord-300850-59j1m2tm 84 3 context context NN cord-300850-59j1m2tm 84 4 of of IN cord-300850-59j1m2tm 84 5 SARS SARS NNP cord-300850-59j1m2tm 84 6 - - HYPH cord-300850-59j1m2tm 84 7 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 84 8 , , , cord-300850-59j1m2tm 84 9 it -PRON- PRP cord-300850-59j1m2tm 84 10 is be VBZ cord-300850-59j1m2tm 84 11 plausible plausible JJ cord-300850-59j1m2tm 84 12 to to TO cord-300850-59j1m2tm 84 13 think think VB cord-300850-59j1m2tm 84 14 that that IN cord-300850-59j1m2tm 84 15 ADE ADE NNP cord-300850-59j1m2tm 84 16 occurs occur VBZ cord-300850-59j1m2tm 84 17 . . . cord-300850-59j1m2tm 85 1 As as IN cord-300850-59j1m2tm 85 2 mentioned mention VBN cord-300850-59j1m2tm 85 3 in in IN cord-300850-59j1m2tm 85 4 the the DT cord-300850-59j1m2tm 85 5 introduction introduction NN cord-300850-59j1m2tm 85 6 section section NN cord-300850-59j1m2tm 85 7 , , , cord-300850-59j1m2tm 85 8 elderly elderly JJ cord-300850-59j1m2tm 85 9 ( ( -LRB- cord-300850-59j1m2tm 85 10 460 460 CD cord-300850-59j1m2tm 85 11 yr yr NN cord-300850-59j1m2tm 85 12 ) ) -RRB- cord-300850-59j1m2tm 85 13 patients patient NNS cord-300850-59j1m2tm 85 14 are be VBP cord-300850-59j1m2tm 85 15 more more RBR cord-300850-59j1m2tm 85 16 susceptible susceptible JJ cord-300850-59j1m2tm 85 17 to to IN cord-300850-59j1m2tm 85 18 infection infection NN cord-300850-59j1m2tm 85 19 for for IN cord-300850-59j1m2tm 85 20 unknown unknown JJ cord-300850-59j1m2tm 85 21 reasons reason NNS cord-300850-59j1m2tm 85 22 . . . cord-300850-59j1m2tm 86 1 As as IN cord-300850-59j1m2tm 86 2 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 86 3 in in IN cord-300850-59j1m2tm 86 4 general general JJ cord-300850-59j1m2tm 86 5 are be VBP cord-300850-59j1m2tm 86 6 highly highly RB cord-300850-59j1m2tm 86 7 prevalent prevalent JJ cord-300850-59j1m2tm 86 8 in in IN cord-300850-59j1m2tm 86 9 the the DT cord-300850-59j1m2tm 86 10 global global JJ cord-300850-59j1m2tm 86 11 population population NN cord-300850-59j1m2tm 86 12 , , , cord-300850-59j1m2tm 86 13 causing cause VBG cord-300850-59j1m2tm 86 14 mild mild JJ cord-300850-59j1m2tm 86 15 infection infection NN cord-300850-59j1m2tm 86 16 and and CC cord-300850-59j1m2tm 86 17 flu flu NN cord-300850-59j1m2tm 86 18 - - HYPH cord-300850-59j1m2tm 86 19 like like JJ cord-300850-59j1m2tm 86 20 symptoms symptom NNS cord-300850-59j1m2tm 86 21 , , , cord-300850-59j1m2tm 86 22 seroconversion seroconversion NN cord-300850-59j1m2tm 86 23 into into IN cord-300850-59j1m2tm 86 24 previous previous JJ cord-300850-59j1m2tm 86 25 circulating circulate VBG cord-300850-59j1m2tm 86 26 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 86 27 is be VBZ cord-300850-59j1m2tm 86 28 probably probably RB cord-300850-59j1m2tm 86 29 widespread widespread JJ cord-300850-59j1m2tm 86 30 . . . cord-300850-59j1m2tm 87 1 Thus thus RB cord-300850-59j1m2tm 87 2 , , , cord-300850-59j1m2tm 87 3 it -PRON- PRP cord-300850-59j1m2tm 87 4 is be VBZ cord-300850-59j1m2tm 87 5 reasonable reasonable JJ cord-300850-59j1m2tm 87 6 to to TO cord-300850-59j1m2tm 87 7 infer infer VB cord-300850-59j1m2tm 87 8 that that IN cord-300850-59j1m2tm 87 9 elderly elderly JJ cord-300850-59j1m2tm 87 10 patients patient NNS cord-300850-59j1m2tm 87 11 , , , cord-300850-59j1m2tm 87 12 for for IN cord-300850-59j1m2tm 87 13 obvious obvious JJ cord-300850-59j1m2tm 87 14 reasons reason NNS cord-300850-59j1m2tm 87 15 , , , cord-300850-59j1m2tm 87 16 have have VBP cord-300850-59j1m2tm 87 17 been be VBN cord-300850-59j1m2tm 87 18 exposed expose VBN cord-300850-59j1m2tm 87 19 to to IN cord-300850-59j1m2tm 87 20 previous previous JJ cord-300850-59j1m2tm 87 21 infections infection NNS cord-300850-59j1m2tm 87 22 more more JJR cord-300850-59j1m2tm 87 23 times time NNS cord-300850-59j1m2tm 87 24 than than IN cord-300850-59j1m2tm 87 25 younger young JJR cord-300850-59j1m2tm 87 26 subjects subject NNS cord-300850-59j1m2tm 87 27 . . . cord-300850-59j1m2tm 88 1 This this DT cord-300850-59j1m2tm 88 2 would would MD cord-300850-59j1m2tm 88 3 imply imply VB cord-300850-59j1m2tm 88 4 a a DT cord-300850-59j1m2tm 88 5 vaster vast JJR cord-300850-59j1m2tm 88 6 repertoire repertoire NN cord-300850-59j1m2tm 88 7 of of IN cord-300850-59j1m2tm 88 8 antibodies antibody NNS cord-300850-59j1m2tm 88 9 against against IN cord-300850-59j1m2tm 88 10 coronavirus coronavirus NN cord-300850-59j1m2tm 88 11 epitopes epitope NNS cord-300850-59j1m2tm 88 12 produced produce VBN cord-300850-59j1m2tm 88 13 by by IN cord-300850-59j1m2tm 88 14 longliving longlive VBG cord-300850-59j1m2tm 88 15 plasma plasma NN cord-300850-59j1m2tm 88 16 cells cell NNS cord-300850-59j1m2tm 88 17 , , , cord-300850-59j1m2tm 88 18 which which WDT cord-300850-59j1m2tm 88 19 in in IN cord-300850-59j1m2tm 88 20 fact fact NN cord-300850-59j1m2tm 88 21 has have VBZ cord-300850-59j1m2tm 88 22 recently recently RB cord-300850-59j1m2tm 88 23 been be VBN cord-300850-59j1m2tm 88 24 shown show VBN cord-300850-59j1m2tm 88 25 to to TO cord-300850-59j1m2tm 88 26 expand expand VB cord-300850-59j1m2tm 88 27 during during IN cord-300850-59j1m2tm 88 28 SARS SARS NNP cord-300850-59j1m2tm 88 29 - - HYPH cord-300850-59j1m2tm 88 30 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 88 31 infection infection NN cord-300850-59j1m2tm 88 32 . . . cord-300850-59j1m2tm 89 1 However however RB cord-300850-59j1m2tm 89 2 , , , cord-300850-59j1m2tm 89 3 whether whether IN cord-300850-59j1m2tm 89 4 these these DT cord-300850-59j1m2tm 89 5 antibodies antibody NNS cord-300850-59j1m2tm 89 6 are be VBP cord-300850-59j1m2tm 89 7 either either CC cord-300850-59j1m2tm 89 8 neutralizers neutralizer NNS cord-300850-59j1m2tm 89 9 or or CC cord-300850-59j1m2tm 89 10 enhancers enhancer NNS cord-300850-59j1m2tm 89 11 must must MD cord-300850-59j1m2tm 89 12 be be VB cord-300850-59j1m2tm 89 13 further further RB cord-300850-59j1m2tm 89 14 addressed address VBN cord-300850-59j1m2tm 89 15 . . . cord-300850-59j1m2tm 90 1 It -PRON- PRP cord-300850-59j1m2tm 90 2 is be VBZ cord-300850-59j1m2tm 90 3 worth worth JJ cord-300850-59j1m2tm 90 4 mentioning mention VBG cord-300850-59j1m2tm 90 5 that that IN cord-300850-59j1m2tm 90 6 , , , cord-300850-59j1m2tm 90 7 concerning concern VBG cord-300850-59j1m2tm 90 8 the the DT cord-300850-59j1m2tm 90 9 new new JJ cord-300850-59j1m2tm 90 10 SARS SARS NNP cord-300850-59j1m2tm 90 11 - - HYPH cord-300850-59j1m2tm 90 12 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 90 13 , , , cord-300850-59j1m2tm 90 14 sequencing sequence VBG cord-300850-59j1m2tm 90 15 analysis analysis NN cord-300850-59j1m2tm 90 16 of of IN cord-300850-59j1m2tm 90 17 the the DT cord-300850-59j1m2tm 90 18 viral viral JJ cord-300850-59j1m2tm 90 19 genome genome NN cord-300850-59j1m2tm 90 20 isolated isolate VBN cord-300850-59j1m2tm 90 21 in in IN cord-300850-59j1m2tm 90 22 Wuhan Wuhan NNP cord-300850-59j1m2tm 90 23 , , , cord-300850-59j1m2tm 90 24 China China NNP cord-300850-59j1m2tm 90 25 indicated indicate VBD cord-300850-59j1m2tm 90 26 that that IN cord-300850-59j1m2tm 90 27 mutations mutation NNS cord-300850-59j1m2tm 90 28 mainly mainly RB cord-300850-59j1m2tm 90 29 occurred occur VBD cord-300850-59j1m2tm 90 30 within within IN cord-300850-59j1m2tm 90 31 the the DT cord-300850-59j1m2tm 90 32 coding code VBG cord-300850-59j1m2tm 90 33 sequence sequence NN cord-300850-59j1m2tm 90 34 of of IN cord-300850-59j1m2tm 90 35 the the DT cord-300850-59j1m2tm 90 36 spike spike NN cord-300850-59j1m2tm 90 37 protein protein NN cord-300850-59j1m2tm 90 38 , , , cord-300850-59j1m2tm 90 39 which which WDT cord-300850-59j1m2tm 90 40 has have VBZ cord-300850-59j1m2tm 90 41 less less JJR cord-300850-59j1m2tm 90 42 than than IN cord-300850-59j1m2tm 90 43 40 40 CD cord-300850-59j1m2tm 90 44 % % NN cord-300850-59j1m2tm 90 45 sequence sequence NN cord-300850-59j1m2tm 90 46 identity identity NN cord-300850-59j1m2tm 90 47 with with IN cord-300850-59j1m2tm 90 48 that that DT cord-300850-59j1m2tm 90 49 of of IN cord-300850-59j1m2tm 90 50 previously previously RB cord-300850-59j1m2tm 90 51 circulated circulate VBN cord-300850-59j1m2tm 90 52 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 90 53 ( ( -LRB- cord-300850-59j1m2tm 90 54 1 1 CD cord-300850-59j1m2tm 90 55 ) ) -RRB- cord-300850-59j1m2tm 90 56 . . . cord-300850-59j1m2tm 91 1 These these DT cord-300850-59j1m2tm 91 2 mutations mutation NNS cord-300850-59j1m2tm 91 3 may may MD cord-300850-59j1m2tm 91 4 be be VB cord-300850-59j1m2tm 91 5 responsible responsible JJ cord-300850-59j1m2tm 91 6 not not RB cord-300850-59j1m2tm 91 7 only only RB cord-300850-59j1m2tm 91 8 for for IN cord-300850-59j1m2tm 91 9 the the DT cord-300850-59j1m2tm 91 10 spill spill NN cord-300850-59j1m2tm 91 11 over over RP cord-300850-59j1m2tm 91 12 from from IN cord-300850-59j1m2tm 91 13 bats bat NNS cord-300850-59j1m2tm 91 14 to to IN cord-300850-59j1m2tm 91 15 humans human NNS cord-300850-59j1m2tm 91 16 , , , cord-300850-59j1m2tm 91 17 but but CC cord-300850-59j1m2tm 91 18 also also RB cord-300850-59j1m2tm 91 19 for for IN cord-300850-59j1m2tm 91 20 inducing induce VBG cord-300850-59j1m2tm 91 21 ADE ADE NNP cord-300850-59j1m2tm 91 22 , , , cord-300850-59j1m2tm 91 23 as as IN cord-300850-59j1m2tm 91 24 changes change NNS cord-300850-59j1m2tm 91 25 in in IN cord-300850-59j1m2tm 91 26 spike spike NN cord-300850-59j1m2tm 91 27 epitopes epitope NNS cord-300850-59j1m2tm 91 28 may may MD cord-300850-59j1m2tm 91 29 result result VB cord-300850-59j1m2tm 91 30 in in IN cord-300850-59j1m2tm 91 31 interactions interaction NNS cord-300850-59j1m2tm 91 32 with with IN cord-300850-59j1m2tm 91 33 non non JJ cord-300850-59j1m2tm 91 34 - - JJ cord-300850-59j1m2tm 91 35 neutralizing neutralize VBG cord-300850-59j1m2tm 91 36 antibodies antibody NNS cord-300850-59j1m2tm 91 37 . . . cord-300850-59j1m2tm 92 1 Corroborating corroborate VBG cord-300850-59j1m2tm 92 2 this this DT cord-300850-59j1m2tm 92 3 , , , cord-300850-59j1m2tm 92 4 a a DT cord-300850-59j1m2tm 92 5 novel novel NN cord-300850-59j1m2tm 92 6 epitope epitope NN cord-300850-59j1m2tm 92 7 , , , cord-300850-59j1m2tm 92 8 which which WDT cord-300850-59j1m2tm 92 9 was be VBD cord-300850-59j1m2tm 92 10 lacking lack VBG cord-300850-59j1m2tm 92 11 in in IN cord-300850-59j1m2tm 92 12 previous previous JJ cord-300850-59j1m2tm 92 13 isolates isolate NNS cord-300850-59j1m2tm 92 14 , , , cord-300850-59j1m2tm 92 15 was be VBD cord-300850-59j1m2tm 92 16 mapped map VBN cord-300850-59j1m2tm 92 17 ( ( -LRB- cord-300850-59j1m2tm 92 18 33 33 CD cord-300850-59j1m2tm 92 19 ) ) -RRB- cord-300850-59j1m2tm 92 20 . . . cord-300850-59j1m2tm 93 1 As as IN cord-300850-59j1m2tm 93 2 COVID-19 COVID-19 NNP cord-300850-59j1m2tm 93 3 is be VBZ cord-300850-59j1m2tm 93 4 not not RB cord-300850-59j1m2tm 93 5 a a DT cord-300850-59j1m2tm 93 6 hemorrhagic hemorrhagic JJ cord-300850-59j1m2tm 93 7 disease disease NN cord-300850-59j1m2tm 93 8 , , , cord-300850-59j1m2tm 93 9 it -PRON- PRP cord-300850-59j1m2tm 93 10 is be VBZ cord-300850-59j1m2tm 93 11 probable probable JJ cord-300850-59j1m2tm 93 12 that that IN cord-300850-59j1m2tm 93 13 ADE ADE NNP cord-300850-59j1m2tm 93 14 , , , cord-300850-59j1m2tm 93 15 if if IN cord-300850-59j1m2tm 93 16 present present JJ cord-300850-59j1m2tm 93 17 , , , cord-300850-59j1m2tm 93 18 is be VBZ cord-300850-59j1m2tm 93 19 not not RB cord-300850-59j1m2tm 93 20 mediated mediate VBN cord-300850-59j1m2tm 93 21 by by IN cord-300850-59j1m2tm 93 22 endothelial endothelial JJ cord-300850-59j1m2tm 93 23 cells cell NNS cord-300850-59j1m2tm 93 24 . . . cord-300850-59j1m2tm 94 1 However however RB cord-300850-59j1m2tm 94 2 , , , cord-300850-59j1m2tm 94 3 it -PRON- PRP cord-300850-59j1m2tm 94 4 has have VBZ cord-300850-59j1m2tm 94 5 already already RB cord-300850-59j1m2tm 94 6 been be VBN cord-300850-59j1m2tm 94 7 shown show VBN cord-300850-59j1m2tm 94 8 that that IN cord-300850-59j1m2tm 94 9 lung lung NN cord-300850-59j1m2tm 94 10 epithelial epithelial NN cord-300850-59j1m2tm 94 11 cells cell NNS cord-300850-59j1m2tm 94 12 express express VBP cord-300850-59j1m2tm 94 13 high high JJ cord-300850-59j1m2tm 94 14 levels level NNS cord-300850-59j1m2tm 94 15 of of IN cord-300850-59j1m2tm 94 16 FcgRIIa fcgriia NN cord-300850-59j1m2tm 94 17 ( ( -LRB- cord-300850-59j1m2tm 94 18 34 34 CD cord-300850-59j1m2tm 94 19 ) ) -RRB- cord-300850-59j1m2tm 94 20 . . . cord-300850-59j1m2tm 95 1 Moreover moreover RB cord-300850-59j1m2tm 95 2 , , , cord-300850-59j1m2tm 95 3 immune immune JJ cord-300850-59j1m2tm 95 4 cells cell NNS cord-300850-59j1m2tm 95 5 , , , cord-300850-59j1m2tm 95 6 including include VBG cord-300850-59j1m2tm 95 7 monocytes monocyte NNS cord-300850-59j1m2tm 95 8 and and CC cord-300850-59j1m2tm 95 9 dendritic dendritic JJ cord-300850-59j1m2tm 95 10 cells cell NNS cord-300850-59j1m2tm 95 11 , , , cord-300850-59j1m2tm 95 12 highly highly RB cord-300850-59j1m2tm 95 13 express express VB cord-300850-59j1m2tm 95 14 this this DT cord-300850-59j1m2tm 95 15 receptor receptor NN cord-300850-59j1m2tm 95 16 . . . cord-300850-59j1m2tm 96 1 These these DT cord-300850-59j1m2tm 96 2 populations population NNS cord-300850-59j1m2tm 96 3 , , , cord-300850-59j1m2tm 96 4 especially especially RB cord-300850-59j1m2tm 96 5 monocytes monocyte NNS cord-300850-59j1m2tm 96 6 , , , cord-300850-59j1m2tm 96 7 greatly greatly RB cord-300850-59j1m2tm 96 8 account account VBP cord-300850-59j1m2tm 96 9 for for IN cord-300850-59j1m2tm 96 10 the the DT cord-300850-59j1m2tm 96 11 inflammatory inflammatory JJ cord-300850-59j1m2tm 96 12 infiltrate infiltrate NN cord-300850-59j1m2tm 96 13 in in IN cord-300850-59j1m2tm 96 14 the the DT cord-300850-59j1m2tm 96 15 lungs lung NNS cord-300850-59j1m2tm 96 16 during during IN cord-300850-59j1m2tm 96 17 pneumonia pneumonia NN cord-300850-59j1m2tm 96 18 , , , cord-300850-59j1m2tm 96 19 which which WDT cord-300850-59j1m2tm 96 20 is be VBZ cord-300850-59j1m2tm 96 21 consistent consistent JJ cord-300850-59j1m2tm 96 22 with with IN cord-300850-59j1m2tm 96 23 the the DT cord-300850-59j1m2tm 96 24 transient transient JJ cord-300850-59j1m2tm 96 25 lymphopenia lymphopenia NNS cord-300850-59j1m2tm 96 26 observed observe VBN cord-300850-59j1m2tm 96 27 in in IN cord-300850-59j1m2tm 96 28 patients patient NNS cord-300850-59j1m2tm 96 29 as as IN cord-300850-59j1m2tm 96 30 circulating circulate VBG cord-300850-59j1m2tm 96 31 cells cell NNS cord-300850-59j1m2tm 96 32 may may MD cord-300850-59j1m2tm 96 33 migrate migrate VB cord-300850-59j1m2tm 96 34 to to IN cord-300850-59j1m2tm 96 35 the the DT cord-300850-59j1m2tm 96 36 lungs lung NNS cord-300850-59j1m2tm 96 37 . . . cord-300850-59j1m2tm 97 1 Conversely conversely RB cord-300850-59j1m2tm 97 2 , , , cord-300850-59j1m2tm 97 3 lung lung NN cord-300850-59j1m2tm 97 4 imaging imaging NN cord-300850-59j1m2tm 97 5 of of IN cord-300850-59j1m2tm 97 6 patients patient NNS cord-300850-59j1m2tm 97 7 with with IN cord-300850-59j1m2tm 97 8 severe severe JJ cord-300850-59j1m2tm 97 9 COVID-19 covid-19 NN cord-300850-59j1m2tm 97 10 shows show VBZ cord-300850-59j1m2tm 97 11 a a DT cord-300850-59j1m2tm 97 12 great great JJ cord-300850-59j1m2tm 97 13 degree degree NN cord-300850-59j1m2tm 97 14 of of IN cord-300850-59j1m2tm 97 15 lung lung NN cord-300850-59j1m2tm 97 16 opacity opacity NN cord-300850-59j1m2tm 97 17 , , , cord-300850-59j1m2tm 97 18 which which WDT cord-300850-59j1m2tm 97 19 is be VBZ cord-300850-59j1m2tm 97 20 consistent consistent JJ cord-300850-59j1m2tm 97 21 with with IN cord-300850-59j1m2tm 97 22 edema edema NN cord-300850-59j1m2tm 97 23 and and CC cord-300850-59j1m2tm 97 24 cellular cellular JJ cord-300850-59j1m2tm 97 25 infiltrate infiltrate NN cord-300850-59j1m2tm 97 26 ( ( -LRB- cord-300850-59j1m2tm 97 27 5 5 CD cord-300850-59j1m2tm 97 28 ) ) -RRB- cord-300850-59j1m2tm 97 29 . . . cord-300850-59j1m2tm 98 1 Thus thus RB cord-300850-59j1m2tm 98 2 , , , cord-300850-59j1m2tm 98 3 it -PRON- PRP cord-300850-59j1m2tm 98 4 is be VBZ cord-300850-59j1m2tm 98 5 feasible feasible JJ cord-300850-59j1m2tm 98 6 that that IN cord-300850-59j1m2tm 98 7 lung lung NN cord-300850-59j1m2tm 98 8 - - HYPH cord-300850-59j1m2tm 98 9 infiltrating infiltrate VBG cord-300850-59j1m2tm 98 10 monocytes monocyte NNS cord-300850-59j1m2tm 98 11 expressing express VBG cord-300850-59j1m2tm 98 12 FcgR FcgR NNP cord-300850-59j1m2tm 98 13 greatly greatly RB cord-300850-59j1m2tm 98 14 favor favor VB cord-300850-59j1m2tm 98 15 SARS SARS NNP cord-300850-59j1m2tm 98 16 - - HYPH cord-300850-59j1m2tm 98 17 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 98 18 replication replication NN cord-300850-59j1m2tm 98 19 in in IN cord-300850-59j1m2tm 98 20 the the DT cord-300850-59j1m2tm 98 21 lung lung NN cord-300850-59j1m2tm 98 22 tissue tissue NN cord-300850-59j1m2tm 98 23 , , , cord-300850-59j1m2tm 98 24 accounting account VBG cord-300850-59j1m2tm 98 25 for for IN cord-300850-59j1m2tm 98 26 the the DT cord-300850-59j1m2tm 98 27 greater great JJR cord-300850-59j1m2tm 98 28 susceptibility susceptibility NN cord-300850-59j1m2tm 98 29 of of IN cord-300850-59j1m2tm 98 30 the the DT cord-300850-59j1m2tm 98 31 elderly elderly JJ cord-300850-59j1m2tm 98 32 patients patient NNS cord-300850-59j1m2tm 98 33 . . . cord-300850-59j1m2tm 99 1 Corroborating corroborate VBG cord-300850-59j1m2tm 99 2 this this DT cord-300850-59j1m2tm 99 3 hypothesis hypothesis NN cord-300850-59j1m2tm 99 4 , , , cord-300850-59j1m2tm 99 5 young young JJ cord-300850-59j1m2tm 99 6 individuals individual NNS cord-300850-59j1m2tm 99 7 and and CC cord-300850-59j1m2tm 99 8 children child NNS cord-300850-59j1m2tm 99 9 do do VBP cord-300850-59j1m2tm 99 10 not not RB cord-300850-59j1m2tm 99 11 represent represent VB cord-300850-59j1m2tm 99 12 the the DT cord-300850-59j1m2tm 99 13 risk risk NN cord-300850-59j1m2tm 99 14 group group NN cord-300850-59j1m2tm 99 15 for for IN cord-300850-59j1m2tm 99 16 severe severe JJ cord-300850-59j1m2tm 99 17 disease disease NN cord-300850-59j1m2tm 99 18 , , , cord-300850-59j1m2tm 99 19 which which WDT cord-300850-59j1m2tm 99 20 greatly greatly RB cord-300850-59j1m2tm 99 21 differs differ VBZ cord-300850-59j1m2tm 99 22 from from IN cord-300850-59j1m2tm 99 23 the the DT cord-300850-59j1m2tm 99 24 case case NN cord-300850-59j1m2tm 99 25 of of IN cord-300850-59j1m2tm 99 26 influenza influenza NN cord-300850-59j1m2tm 99 27 ( ( -LRB- cord-300850-59j1m2tm 99 28 7 7 CD cord-300850-59j1m2tm 99 29 ) ) -RRB- cord-300850-59j1m2tm 99 30 , , , cord-300850-59j1m2tm 99 31 for for IN cord-300850-59j1m2tm 99 32 instance instance NN cord-300850-59j1m2tm 99 33 . . . cord-300850-59j1m2tm 100 1 In in IN cord-300850-59j1m2tm 100 2 the the DT cord-300850-59j1m2tm 100 3 context context NN cord-300850-59j1m2tm 100 4 of of IN cord-300850-59j1m2tm 100 5 ADE ADE NNP cord-300850-59j1m2tm 100 6 , , , cord-300850-59j1m2tm 100 7 it -PRON- PRP cord-300850-59j1m2tm 100 8 is be VBZ cord-300850-59j1m2tm 100 9 plausible plausible JJ cord-300850-59j1m2tm 100 10 to to TO cord-300850-59j1m2tm 100 11 think think VB cord-300850-59j1m2tm 100 12 that that IN cord-300850-59j1m2tm 100 13 children child NNS cord-300850-59j1m2tm 100 14 - - : cord-300850-59j1m2tm 100 15 as as IN cord-300850-59j1m2tm 100 16 they -PRON- PRP cord-300850-59j1m2tm 100 17 had have VBD cord-300850-59j1m2tm 100 18 less less JJR cord-300850-59j1m2tm 100 19 or or CC cord-300850-59j1m2tm 100 20 no no DT cord-300850-59j1m2tm 100 21 exposure exposure NN cord-300850-59j1m2tm 100 22 to to IN cord-300850-59j1m2tm 100 23 previous previous JJ cord-300850-59j1m2tm 100 24 circulating circulate VBG cord-300850-59j1m2tm 100 25 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 100 26 - - , cord-300850-59j1m2tm 100 27 carry carry VBP cord-300850-59j1m2tm 100 28 a a DT cord-300850-59j1m2tm 100 29 very very RB cord-300850-59j1m2tm 100 30 restricted restricted JJ cord-300850-59j1m2tm 100 31 repertoire repertoire NN cord-300850-59j1m2tm 100 32 of of IN cord-300850-59j1m2tm 100 33 IgG igg NN cord-300850-59j1m2tm 100 34 - - : cord-300850-59j1m2tm 100 35 or or CC cord-300850-59j1m2tm 100 36 only only RB cord-300850-59j1m2tm 100 37 low low JJ cord-300850-59j1m2tm 100 38 - - HYPH cord-300850-59j1m2tm 100 39 affinity affinity NN cord-300850-59j1m2tm 100 40 IgM IgM NNP cord-300850-59j1m2tm 100 41 - - : cord-300850-59j1m2tm 100 42 which which WDT cord-300850-59j1m2tm 100 43 is be VBZ cord-300850-59j1m2tm 100 44 not not RB cord-300850-59j1m2tm 100 45 capable capable JJ cord-300850-59j1m2tm 100 46 of of IN cord-300850-59j1m2tm 100 47 inducing induce VBG cord-300850-59j1m2tm 100 48 ADE ADE NNP cord-300850-59j1m2tm 100 49 . . . cord-300850-59j1m2tm 101 1 In in IN cord-300850-59j1m2tm 101 2 this this DT cord-300850-59j1m2tm 101 3 context context NN cord-300850-59j1m2tm 101 4 , , , cord-300850-59j1m2tm 101 5 mapping mapping NN cord-300850-59j1m2tm 101 6 complementarity complementarity NN cord-300850-59j1m2tm 101 7 determining determine VBG cord-300850-59j1m2tm 101 8 regions region NNS cord-300850-59j1m2tm 101 9 ( ( -LRB- cord-300850-59j1m2tm 101 10 CDRs cdr NNS cord-300850-59j1m2tm 101 11 ) ) -RRB- cord-300850-59j1m2tm 101 12 in in IN cord-300850-59j1m2tm 101 13 IgGs IgGs NNP cord-300850-59j1m2tm 101 14 from from IN cord-300850-59j1m2tm 101 15 young young JJ cord-300850-59j1m2tm 101 16 and and CC cord-300850-59j1m2tm 101 17 elderly elderly JJ cord-300850-59j1m2tm 101 18 individuals individual NNS cord-300850-59j1m2tm 101 19 would would MD cord-300850-59j1m2tm 101 20 be be VB cord-300850-59j1m2tm 101 21 of of IN cord-300850-59j1m2tm 101 22 great great JJ cord-300850-59j1m2tm 101 23 importance importance NN cord-300850-59j1m2tm 101 24 not not RB cord-300850-59j1m2tm 101 25 only only RB cord-300850-59j1m2tm 101 26 to to TO cord-300850-59j1m2tm 101 27 find find VB cord-300850-59j1m2tm 101 28 neutralizing neutralize VBG cord-300850-59j1m2tm 101 29 antibodies antibody NNS cord-300850-59j1m2tm 101 30 but but CC cord-300850-59j1m2tm 101 31 also also RB cord-300850-59j1m2tm 101 32 to to TO cord-300850-59j1m2tm 101 33 address address VB cord-300850-59j1m2tm 101 34 this this DT cord-300850-59j1m2tm 101 35 hypothesis hypothesis NN cord-300850-59j1m2tm 101 36 . . . cord-300850-59j1m2tm 102 1 Additionally additionally RB cord-300850-59j1m2tm 102 2 , , , cord-300850-59j1m2tm 102 3 previous previous JJ cord-300850-59j1m2tm 102 4 studies study NNS cord-300850-59j1m2tm 102 5 on on IN cord-300850-59j1m2tm 102 6 MERS MERS NNP cord-300850-59j1m2tm 102 7 and and CC cord-300850-59j1m2tm 102 8 SARS SARS NNP cord-300850-59j1m2tm 102 9 have have VBP cord-300850-59j1m2tm 102 10 already already RB cord-300850-59j1m2tm 102 11 highlighted highlight VBN cord-300850-59j1m2tm 102 12 the the DT cord-300850-59j1m2tm 102 13 possibility possibility NN cord-300850-59j1m2tm 102 14 of of IN cord-300850-59j1m2tm 102 15 ADE ADE NNP cord-300850-59j1m2tm 102 16 . . . cord-300850-59j1m2tm 103 1 A a DT cord-300850-59j1m2tm 103 2 recent recent JJ cord-300850-59j1m2tm 103 3 report report NN cord-300850-59j1m2tm 103 4 published publish VBN cord-300850-59j1m2tm 103 5 by by IN cord-300850-59j1m2tm 103 6 Wan Wan NNP cord-300850-59j1m2tm 103 7 Y Y NNP cord-300850-59j1m2tm 103 8 et et FW cord-300850-59j1m2tm 103 9 al al NNP cord-300850-59j1m2tm 103 10 . . . cord-300850-59j1m2tm 104 1 elucidated elucidate VBD cord-300850-59j1m2tm 104 2 the the DT cord-300850-59j1m2tm 104 3 mechanism mechanism NN cord-300850-59j1m2tm 104 4 by by IN cord-300850-59j1m2tm 104 5 which which WDT cord-300850-59j1m2tm 104 6 monoclonal monoclonal JJ cord-300850-59j1m2tm 104 7 antibodies antibody NNS cord-300850-59j1m2tm 104 8 ( ( -LRB- cord-300850-59j1m2tm 104 9 mAbs mAbs NNP cord-300850-59j1m2tm 104 10 ) ) -RRB- cord-300850-59j1m2tm 104 11 induce induce VB cord-300850-59j1m2tm 104 12 ADE ADE NNP cord-300850-59j1m2tm 104 13 in in IN cord-300850-59j1m2tm 104 14 human human JJ cord-300850-59j1m2tm 104 15 cells cell NNS cord-300850-59j1m2tm 104 16 . . . cord-300850-59j1m2tm 105 1 Interestingly interestingly RB cord-300850-59j1m2tm 105 2 , , , cord-300850-59j1m2tm 105 3 mAbs mAbs NNP cord-300850-59j1m2tm 105 4 that that WDT cord-300850-59j1m2tm 105 5 target target NN cord-300850-59j1m2tm 105 6 the the DT cord-300850-59j1m2tm 105 7 RBD RBD NNP cord-300850-59j1m2tm 105 8 of of IN cord-300850-59j1m2tm 105 9 SARS SARS NNP cord-300850-59j1m2tm 105 10 and and CC cord-300850-59j1m2tm 105 11 MERS MERS NNP cord-300850-59j1m2tm 105 12 spike spike NN cord-300850-59j1m2tm 105 13 proteins protein NNS cord-300850-59j1m2tm 105 14 induced induce VBN cord-300850-59j1m2tm 105 15 conformational conformational JJ cord-300850-59j1m2tm 105 16 changes change NNS cord-300850-59j1m2tm 105 17 in in IN cord-300850-59j1m2tm 105 18 the the DT cord-300850-59j1m2tm 105 19 protein protein NN cord-300850-59j1m2tm 105 20 that that WDT cord-300850-59j1m2tm 105 21 favors favor VBZ cord-300850-59j1m2tm 105 22 an an DT cord-300850-59j1m2tm 105 23 interaction interaction NN cord-300850-59j1m2tm 105 24 with with IN cord-300850-59j1m2tm 105 25 dipeptidyl dipeptidyl JJ cord-300850-59j1m2tm 105 26 peptidase peptidase NN cord-300850-59j1m2tm 105 27 4 4 CD cord-300850-59j1m2tm 105 28 ( ( -LRB- cord-300850-59j1m2tm 105 29 DPP4 DPP4 NNP cord-300850-59j1m2tm 105 30 ) ) -RRB- cord-300850-59j1m2tm 105 31 , , , cord-300850-59j1m2tm 105 32 the the DT cord-300850-59j1m2tm 105 33 receptor receptor NN cord-300850-59j1m2tm 105 34 for for IN cord-300850-59j1m2tm 105 35 MERS MERS NNP cord-300850-59j1m2tm 105 36 ( ( -LRB- cord-300850-59j1m2tm 105 37 38 38 CD cord-300850-59j1m2tm 105 38 ) ) -RRB- cord-300850-59j1m2tm 105 39 . . . cord-300850-59j1m2tm 106 1 Moreover moreover RB cord-300850-59j1m2tm 106 2 , , , cord-300850-59j1m2tm 106 3 immunocomplexes immunocomplexes NNP cord-300850-59j1m2tm 106 4 also also RB cord-300850-59j1m2tm 106 5 promoted promote VBD cord-300850-59j1m2tm 106 6 viral viral JJ cord-300850-59j1m2tm 106 7 entry entry NN cord-300850-59j1m2tm 106 8 . . . cord-300850-59j1m2tm 107 1 However however RB cord-300850-59j1m2tm 107 2 , , , cord-300850-59j1m2tm 107 3 increasing increase VBG cord-300850-59j1m2tm 107 4 concentrations concentration NNS cord-300850-59j1m2tm 107 5 of of IN cord-300850-59j1m2tm 107 6 antibodies antibody NNS cord-300850-59j1m2tm 107 7 block block VBP cord-300850-59j1m2tm 107 8 viral viral JJ cord-300850-59j1m2tm 107 9 invasion invasion NN cord-300850-59j1m2tm 107 10 , , , cord-300850-59j1m2tm 107 11 as as IN cord-300850-59j1m2tm 107 12 RBDs RBDs NNP cord-300850-59j1m2tm 107 13 become become VBP cord-300850-59j1m2tm 107 14 inaccessible inaccessible JJ cord-300850-59j1m2tm 107 15 . . . cord-300850-59j1m2tm 108 1 This this DT cord-300850-59j1m2tm 108 2 is be VBZ cord-300850-59j1m2tm 108 3 consistent consistent JJ cord-300850-59j1m2tm 108 4 with with IN cord-300850-59j1m2tm 108 5 previous previous JJ cord-300850-59j1m2tm 108 6 findings finding NNS cord-300850-59j1m2tm 108 7 by by IN cord-300850-59j1m2tm 108 8 Wang Wang NNP cord-300850-59j1m2tm 108 9 Q Q NNP cord-300850-59j1m2tm 108 10 et et NNP cord-300850-59j1m2tm 108 11 al al NNP cord-300850-59j1m2tm 108 12 . . . cord-300850-59j1m2tm 109 1 ( ( -LRB- cord-300850-59j1m2tm 109 2 39 39 CD cord-300850-59j1m2tm 109 3 ) ) -RRB- cord-300850-59j1m2tm 109 4 who who WP cord-300850-59j1m2tm 109 5 infected infect VBD cord-300850-59j1m2tm 109 6 the the DT cord-300850-59j1m2tm 109 7 promonocytic promonocytic JJ cord-300850-59j1m2tm 109 8 cell cell NN cord-300850-59j1m2tm 109 9 line line NN cord-300850-59j1m2tm 109 10 HL HL NNP cord-300850-59j1m2tm 109 11 - - HYPH cord-300850-59j1m2tm 109 12 CZ CZ NNP cord-300850-59j1m2tm 109 13 - - : cord-300850-59j1m2tm 109 14 that that WDT cord-300850-59j1m2tm 109 15 expresses express VBZ cord-300850-59j1m2tm 109 16 both both DT cord-300850-59j1m2tm 109 17 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 109 18 and and CC cord-300850-59j1m2tm 109 19 FcgR FcgR NNP cord-300850-59j1m2tm 109 20 - - HYPH cord-300850-59j1m2tm 109 21 with with IN cord-300850-59j1m2tm 109 22 SARS SARS NNP cord-300850-59j1m2tm 109 23 - - HYPH cord-300850-59j1m2tm 109 24 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 109 25 in in IN cord-300850-59j1m2tm 109 26 the the DT cord-300850-59j1m2tm 109 27 presence presence NN cord-300850-59j1m2tm 109 28 of of IN cord-300850-59j1m2tm 109 29 increasing increase VBG cord-300850-59j1m2tm 109 30 concentrations concentration NNS cord-300850-59j1m2tm 109 31 of of IN cord-300850-59j1m2tm 109 32 anti anti JJ cord-300850-59j1m2tm 109 33 - - JJ cord-300850-59j1m2tm 109 34 sera sera JJ cord-300850-59j1m2tm 109 35 . . . cord-300850-59j1m2tm 110 1 Their -PRON- PRP$ cord-300850-59j1m2tm 110 2 data datum NNS cord-300850-59j1m2tm 110 3 demonstrated demonstrate VBD cord-300850-59j1m2tm 110 4 that that IN cord-300850-59j1m2tm 110 5 high high JJ cord-300850-59j1m2tm 110 6 concentrations concentration NNS cord-300850-59j1m2tm 110 7 of of IN cord-300850-59j1m2tm 110 8 antibodies antibody NNS cord-300850-59j1m2tm 110 9 neutralized neutralize VBD cord-300850-59j1m2tm 110 10 the the DT cord-300850-59j1m2tm 110 11 virus virus NN cord-300850-59j1m2tm 110 12 , , , cord-300850-59j1m2tm 110 13 whereas whereas IN cord-300850-59j1m2tm 110 14 lower low JJR cord-300850-59j1m2tm 110 15 concentrations concentration NNS cord-300850-59j1m2tm 110 16 induced induce VBN cord-300850-59j1m2tm 110 17 ADE ADE NNP cord-300850-59j1m2tm 110 18 . . . cord-300850-59j1m2tm 111 1 More more RBR cord-300850-59j1m2tm 111 2 interestingly interestingly RB cord-300850-59j1m2tm 111 3 , , , cord-300850-59j1m2tm 111 4 the the DT cord-300850-59j1m2tm 111 5 anti anti NNP cord-300850-59j1m2tm 111 6 - - NNP cord-300850-59j1m2tm 111 7 sera sera NNP cord-300850-59j1m2tm 111 8 also also RB cord-300850-59j1m2tm 111 9 recognized recognize VBD cord-300850-59j1m2tm 111 10 spike spike NN cord-300850-59j1m2tm 111 11 protein protein NN cord-300850-59j1m2tm 111 12 - - HYPH cord-300850-59j1m2tm 111 13 related relate VBN cord-300850-59j1m2tm 111 14 antigens antigen NNS cord-300850-59j1m2tm 111 15 . . . cord-300850-59j1m2tm 112 1 Another another DT cord-300850-59j1m2tm 112 2 study study NN cord-300850-59j1m2tm 112 3 on on IN cord-300850-59j1m2tm 112 4 SARS SARS NNP cord-300850-59j1m2tm 112 5 - - HYPH cord-300850-59j1m2tm 112 6 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 112 7 using use VBG cord-300850-59j1m2tm 112 8 Rhesus Rhesus NNP cord-300850-59j1m2tm 112 9 monkeys monkey NNS cord-300850-59j1m2tm 112 10 showed show VBD cord-300850-59j1m2tm 112 11 that that IN cord-300850-59j1m2tm 112 12 immunization immunization NN cord-300850-59j1m2tm 112 13 with with IN cord-300850-59j1m2tm 112 14 full full JJ cord-300850-59j1m2tm 112 15 - - HYPH cord-300850-59j1m2tm 112 16 length length NN cord-300850-59j1m2tm 112 17 SPIKE spike NN cord-300850-59j1m2tm 112 18 glycoprotein glycoprotein NN cord-300850-59j1m2tm 112 19 led lead VBD cord-300850-59j1m2tm 112 20 to to IN cord-300850-59j1m2tm 112 21 increased increase VBN cord-300850-59j1m2tm 112 22 disease disease NN cord-300850-59j1m2tm 112 23 severity severity NN cord-300850-59j1m2tm 112 24 , , , cord-300850-59j1m2tm 112 25 mostly mostly RB cord-300850-59j1m2tm 112 26 to to IN cord-300850-59j1m2tm 112 27 because because IN cord-300850-59j1m2tm 112 28 of of IN cord-300850-59j1m2tm 112 29 an an DT cord-300850-59j1m2tm 112 30 increase increase NN cord-300850-59j1m2tm 112 31 in in IN cord-300850-59j1m2tm 112 32 neutralizing neutralize VBG cord-300850-59j1m2tm 112 33 antibodies antibody NNS cord-300850-59j1m2tm 112 34 ( ( -LRB- cord-300850-59j1m2tm 112 35 NAb NAb NNS cord-300850-59j1m2tm 112 36 ) ) -RRB- cord-300850-59j1m2tm 112 37 ( ( -LRB- cord-300850-59j1m2tm 112 38 35 35 CD cord-300850-59j1m2tm 112 39 ) ) -RRB- cord-300850-59j1m2tm 112 40 . . . cord-300850-59j1m2tm 113 1 The the DT cord-300850-59j1m2tm 113 2 study study NN cord-300850-59j1m2tm 113 3 demonstrated demonstrate VBD cord-300850-59j1m2tm 113 4 that that IN cord-300850-59j1m2tm 113 5 NAbs NAbs NNP cord-300850-59j1m2tm 113 6 switched switch VBD cord-300850-59j1m2tm 113 7 the the DT cord-300850-59j1m2tm 113 8 phenotype phenotype NN cord-300850-59j1m2tm 113 9 of of IN cord-300850-59j1m2tm 113 10 lunginfiltrating lunginfiltrate VBG cord-300850-59j1m2tm 113 11 macrophages macrophage NNS cord-300850-59j1m2tm 113 12 to to IN cord-300850-59j1m2tm 113 13 a a DT cord-300850-59j1m2tm 113 14 pro pro JJ cord-300850-59j1m2tm 113 15 - - JJ cord-300850-59j1m2tm 113 16 inflammatory inflammatory JJ cord-300850-59j1m2tm 113 17 M1 M1 NNP cord-300850-59j1m2tm 113 18 profile profile NN cord-300850-59j1m2tm 113 19 , , , cord-300850-59j1m2tm 113 20 instead instead RB cord-300850-59j1m2tm 113 21 of of IN cord-300850-59j1m2tm 113 22 the the DT cord-300850-59j1m2tm 113 23 tissue tissue NN cord-300850-59j1m2tm 113 24 - - HYPH cord-300850-59j1m2tm 113 25 healing heal VBG cord-300850-59j1m2tm 113 26 profile profile NN cord-300850-59j1m2tm 113 27 M2 m2 NN cord-300850-59j1m2tm 113 28 . . . cord-300850-59j1m2tm 114 1 This this DT cord-300850-59j1m2tm 114 2 aggravated aggravated JJ cord-300850-59j1m2tm 114 3 lung lung NN cord-300850-59j1m2tm 114 4 injury injury NN cord-300850-59j1m2tm 114 5 and and CC cord-300850-59j1m2tm 114 6 greatly greatly RB cord-300850-59j1m2tm 114 7 contributed contribute VBD cord-300850-59j1m2tm 114 8 to to IN cord-300850-59j1m2tm 114 9 its -PRON- PRP$ cord-300850-59j1m2tm 114 10 pathology pathology NN cord-300850-59j1m2tm 114 11 . . . cord-300850-59j1m2tm 115 1 Conversely conversely RB cord-300850-59j1m2tm 115 2 , , , cord-300850-59j1m2tm 115 3 previous previous JJ cord-300850-59j1m2tm 115 4 studies study NNS cord-300850-59j1m2tm 115 5 using use VBG cord-300850-59j1m2tm 115 6 samples sample NNS cord-300850-59j1m2tm 115 7 from from IN cord-300850-59j1m2tm 115 8 deceased deceased JJ cord-300850-59j1m2tm 115 9 patients patient NNS cord-300850-59j1m2tm 115 10 suffering suffer VBG cord-300850-59j1m2tm 115 11 from from IN cord-300850-59j1m2tm 115 12 SARS SARS NNP cord-300850-59j1m2tm 115 13 - - HYPH cord-300850-59j1m2tm 115 14 CoV CoV NNP cord-300850-59j1m2tm 115 15 infection infection NN cord-300850-59j1m2tm 115 16 indicated indicate VBD cord-300850-59j1m2tm 115 17 that that IN cord-300850-59j1m2tm 115 18 NAb NAb NNS cord-300850-59j1m2tm 115 19 titers titer NNS cord-300850-59j1m2tm 115 20 reached reach VBD cord-300850-59j1m2tm 115 21 higher high JJR cord-300850-59j1m2tm 115 22 levels level NNS cord-300850-59j1m2tm 115 23 earlier early RBR cord-300850-59j1m2tm 115 24 in in IN cord-300850-59j1m2tm 115 25 these these DT cord-300850-59j1m2tm 115 26 patients patient NNS cord-300850-59j1m2tm 115 27 , , , cord-300850-59j1m2tm 115 28 compared compare VBN cord-300850-59j1m2tm 115 29 to to IN cord-300850-59j1m2tm 115 30 that that DT cord-300850-59j1m2tm 115 31 in in IN cord-300850-59j1m2tm 115 32 patients patient NNS cord-300850-59j1m2tm 115 33 who who WP cord-300850-59j1m2tm 115 34 survived survive VBD cord-300850-59j1m2tm 115 35 ( ( -LRB- cord-300850-59j1m2tm 115 36 36 36 CD cord-300850-59j1m2tm 115 37 ) ) -RRB- cord-300850-59j1m2tm 115 38 . . . cord-300850-59j1m2tm 116 1 This this DT cord-300850-59j1m2tm 116 2 may may MD cord-300850-59j1m2tm 116 3 indicate indicate VB cord-300850-59j1m2tm 116 4 that that IN cord-300850-59j1m2tm 116 5 ADE ADE NNP cord-300850-59j1m2tm 116 6 and and CC cord-300850-59j1m2tm 116 7 the the DT cord-300850-59j1m2tm 116 8 role role NN cord-300850-59j1m2tm 116 9 of of IN cord-300850-59j1m2tm 116 10 preexisting preexisting JJ cord-300850-59j1m2tm 116 11 antibodies antibody NNS cord-300850-59j1m2tm 116 12 are be VBP cord-300850-59j1m2tm 116 13 in in IN cord-300850-59j1m2tm 116 14 fact fact NN cord-300850-59j1m2tm 116 15 very very RB cord-300850-59j1m2tm 116 16 relevant relevant JJ cord-300850-59j1m2tm 116 17 to to IN cord-300850-59j1m2tm 116 18 the the DT cord-300850-59j1m2tm 116 19 overall overall JJ cord-300850-59j1m2tm 116 20 outcome outcome NN cord-300850-59j1m2tm 116 21 of of IN cord-300850-59j1m2tm 116 22 the the DT cord-300850-59j1m2tm 116 23 infection infection NN cord-300850-59j1m2tm 116 24 . . . cord-300850-59j1m2tm 117 1 Thus thus RB cord-300850-59j1m2tm 117 2 , , , cord-300850-59j1m2tm 117 3 as as IN cord-300850-59j1m2tm 117 4 indicated indicate VBN cord-300850-59j1m2tm 117 5 in in IN cord-300850-59j1m2tm 117 6 Figure figure NN cord-300850-59j1m2tm 117 7 2 2 CD cord-300850-59j1m2tm 117 8 , , , cord-300850-59j1m2tm 117 9 circulating circulate VBG cord-300850-59j1m2tm 117 10 antibodies antibody NNS cord-300850-59j1m2tm 117 11 , , , cord-300850-59j1m2tm 117 12 instead instead RB cord-300850-59j1m2tm 117 13 of of IN cord-300850-59j1m2tm 117 14 neutralizing neutralize VBG cord-300850-59j1m2tm 117 15 the the DT cord-300850-59j1m2tm 117 16 current current JJ cord-300850-59j1m2tm 117 17 circulating circulate VBG cord-300850-59j1m2tm 117 18 SARS SARS NNP cord-300850-59j1m2tm 117 19 - - HYPH cord-300850-59j1m2tm 117 20 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 117 21 , , , cord-300850-59j1m2tm 117 22 may may MD cord-300850-59j1m2tm 117 23 bind bind VB cord-300850-59j1m2tm 117 24 to to IN cord-300850-59j1m2tm 117 25 viral viral JJ cord-300850-59j1m2tm 117 26 particles particle NNS cord-300850-59j1m2tm 117 27 and and CC cord-300850-59j1m2tm 117 28 thus thus RB cord-300850-59j1m2tm 117 29 promote promote VB cord-300850-59j1m2tm 117 30 Fc Fc NNP cord-300850-59j1m2tm 117 31 - - HYPH cord-300850-59j1m2tm 117 32 mediated mediate VBN cord-300850-59j1m2tm 117 33 internalization internalization NN cord-300850-59j1m2tm 117 34 by by IN cord-300850-59j1m2tm 117 35 lung lung NN cord-300850-59j1m2tm 117 36 epithelial epithelial JJ cord-300850-59j1m2tm 117 37 cells cell NNS cord-300850-59j1m2tm 117 38 and and CC cord-300850-59j1m2tm 117 39 infiltrating infiltrate VBG cord-300850-59j1m2tm 117 40 monocytes monocyte NNS cord-300850-59j1m2tm 117 41 , , , cord-300850-59j1m2tm 117 42 contributing contribute VBG cord-300850-59j1m2tm 117 43 to to IN cord-300850-59j1m2tm 117 44 the the DT cord-300850-59j1m2tm 117 45 worsening worsening NN cord-300850-59j1m2tm 117 46 of of IN cord-300850-59j1m2tm 117 47 COVID-19 COVID-19 NNP cord-300850-59j1m2tm 117 48 . . . cord-300850-59j1m2tm 118 1 These these DT cord-300850-59j1m2tm 118 2 are be VBP cord-300850-59j1m2tm 118 3 the the DT cord-300850-59j1m2tm 118 4 most most RBS cord-300850-59j1m2tm 118 5 recent recent JJ cord-300850-59j1m2tm 118 6 and and CC cord-300850-59j1m2tm 118 7 mechanistic mechanistic JJ cord-300850-59j1m2tm 118 8 studies study NNS cord-300850-59j1m2tm 118 9 on on IN cord-300850-59j1m2tm 118 10 ADE ADE NNP cord-300850-59j1m2tm 118 11 of of IN cord-300850-59j1m2tm 118 12 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 118 13 thus thus RB cord-300850-59j1m2tm 118 14 far far RB cord-300850-59j1m2tm 118 15 . . . cord-300850-59j1m2tm 119 1 Although although IN cord-300850-59j1m2tm 119 2 the the DT cord-300850-59j1m2tm 119 3 data datum NNS cord-300850-59j1m2tm 119 4 are be VBP cord-300850-59j1m2tm 119 5 consistent consistent JJ cord-300850-59j1m2tm 119 6 , , , cord-300850-59j1m2tm 119 7 whether whether IN cord-300850-59j1m2tm 119 8 the the DT cord-300850-59j1m2tm 119 9 phenomenon phenomenon NN cord-300850-59j1m2tm 119 10 of of IN cord-300850-59j1m2tm 119 11 ADE ADE NNP cord-300850-59j1m2tm 119 12 is be VBZ cord-300850-59j1m2tm 119 13 observed observe VBN cord-300850-59j1m2tm 119 14 in in IN cord-300850-59j1m2tm 119 15 patients patient NNS cord-300850-59j1m2tm 119 16 with with IN cord-300850-59j1m2tm 119 17 severe severe JJ cord-300850-59j1m2tm 119 18 COVID-19 covid-19 NN cord-300850-59j1m2tm 119 19 is be VBZ cord-300850-59j1m2tm 119 20 yet yet RB cord-300850-59j1m2tm 119 21 to to TO cord-300850-59j1m2tm 119 22 be be VB cord-300850-59j1m2tm 119 23 determined determine VBN cord-300850-59j1m2tm 119 24 . . . cord-300850-59j1m2tm 120 1 Noteworthy noteworthy JJ cord-300850-59j1m2tm 120 2 , , , cord-300850-59j1m2tm 120 3 however however RB cord-300850-59j1m2tm 120 4 , , , cord-300850-59j1m2tm 120 5 is be VBZ cord-300850-59j1m2tm 120 6 the the DT cord-300850-59j1m2tm 120 7 fact fact NN cord-300850-59j1m2tm 120 8 that that IN cord-300850-59j1m2tm 120 9 immune immune JJ cord-300850-59j1m2tm 120 10 complexes complex NNS cord-300850-59j1m2tm 120 11 of of IN cord-300850-59j1m2tm 120 12 low low JJ cord-300850-59j1m2tm 120 13 - - HYPH cord-300850-59j1m2tm 120 14 avidity avidity NN cord-300850-59j1m2tm 120 15 antibodies antibody NNS cord-300850-59j1m2tm 120 16 at at IN cord-300850-59j1m2tm 120 17 sub sub JJ cord-300850-59j1m2tm 120 18 - - JJ cord-300850-59j1m2tm 120 19 optimal optimal JJ cord-300850-59j1m2tm 120 20 concentrations concentration NNS cord-300850-59j1m2tm 120 21 were be VBD cord-300850-59j1m2tm 120 22 also also RB cord-300850-59j1m2tm 120 23 responsible responsible JJ cord-300850-59j1m2tm 120 24 for for IN cord-300850-59j1m2tm 120 25 the the DT cord-300850-59j1m2tm 120 26 worsening worsening NN cord-300850-59j1m2tm 120 27 of of IN cord-300850-59j1m2tm 120 28 the the DT cord-300850-59j1m2tm 120 29 pulmonary pulmonary JJ cord-300850-59j1m2tm 120 30 disease disease NN cord-300850-59j1m2tm 120 31 caused cause VBN cord-300850-59j1m2tm 120 32 by by IN cord-300850-59j1m2tm 120 33 H1N1 H1N1 NNP cord-300850-59j1m2tm 120 34 during during IN cord-300850-59j1m2tm 120 35 the the DT cord-300850-59j1m2tm 120 36 2009 2009 CD cord-300850-59j1m2tm 120 37 epidemic epidemic NN cord-300850-59j1m2tm 120 38 ( ( -LRB- cord-300850-59j1m2tm 120 39 37 37 CD cord-300850-59j1m2tm 120 40 ) ) -RRB- cord-300850-59j1m2tm 120 41 . . . cord-300850-59j1m2tm 120 42 ' ' '' cord-300850-59j1m2tm 121 1 CONCLUSIONS CONCLUSIONS NNP cord-300850-59j1m2tm 121 2 SARS SARS NNP cord-300850-59j1m2tm 121 3 - - HYPH cord-300850-59j1m2tm 121 4 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 121 5 is be VBZ cord-300850-59j1m2tm 121 6 the the DT cord-300850-59j1m2tm 121 7 newest new JJS cord-300850-59j1m2tm 121 8 threat threat NN cord-300850-59j1m2tm 121 9 to to IN cord-300850-59j1m2tm 121 10 human human JJ cord-300850-59j1m2tm 121 11 health health NN cord-300850-59j1m2tm 121 12 and and CC cord-300850-59j1m2tm 121 13 needs need VBZ cord-300850-59j1m2tm 121 14 emergency emergency NN cord-300850-59j1m2tm 121 15 action action NN cord-300850-59j1m2tm 121 16 from from IN cord-300850-59j1m2tm 121 17 governments government NNS cord-300850-59j1m2tm 121 18 and and CC cord-300850-59j1m2tm 121 19 public public JJ cord-300850-59j1m2tm 121 20 health health NN cord-300850-59j1m2tm 121 21 agencies agency NNS cord-300850-59j1m2tm 121 22 worldwide worldwide RB cord-300850-59j1m2tm 121 23 , , , cord-300850-59j1m2tm 121 24 especially especially RB cord-300850-59j1m2tm 121 25 because because IN cord-300850-59j1m2tm 121 26 of of IN cord-300850-59j1m2tm 121 27 its -PRON- PRP$ cord-300850-59j1m2tm 121 28 pandemic pandemic NN cord-300850-59j1m2tm 121 29 potential potential NN cord-300850-59j1m2tm 121 30 as as IN cord-300850-59j1m2tm 121 31 recently recently RB cord-300850-59j1m2tm 121 32 declared declare VBN cord-300850-59j1m2tm 121 33 by by IN cord-300850-59j1m2tm 121 34 the the DT cord-300850-59j1m2tm 121 35 World World NNP cord-300850-59j1m2tm 121 36 Health Health NNP cord-300850-59j1m2tm 121 37 Organization Organization NNP cord-300850-59j1m2tm 121 38 ( ( -LRB- cord-300850-59j1m2tm 121 39 WHO who WP cord-300850-59j1m2tm 121 40 ) ) -RRB- cord-300850-59j1m2tm 121 41 . . . cord-300850-59j1m2tm 122 1 In in IN cord-300850-59j1m2tm 122 2 this this DT cord-300850-59j1m2tm 122 3 context context NN cord-300850-59j1m2tm 122 4 , , , cord-300850-59j1m2tm 122 5 it -PRON- PRP cord-300850-59j1m2tm 122 6 is be VBZ cord-300850-59j1m2tm 122 7 essential essential JJ cord-300850-59j1m2tm 122 8 to to TO cord-300850-59j1m2tm 122 9 rapidly rapidly RB cord-300850-59j1m2tm 122 10 and and CC cord-300850-59j1m2tm 122 11 deeply deeply RB cord-300850-59j1m2tm 122 12 address address VB cord-300850-59j1m2tm 122 13 all all PDT cord-300850-59j1m2tm 122 14 the the DT cord-300850-59j1m2tm 122 15 possibilities possibility NNS cord-300850-59j1m2tm 122 16 concerning concern VBG cord-300850-59j1m2tm 122 17 the the DT cord-300850-59j1m2tm 122 18 severity severity NN cord-300850-59j1m2tm 122 19 of of IN cord-300850-59j1m2tm 122 20 infection infection NN cord-300850-59j1m2tm 122 21 , , , cord-300850-59j1m2tm 122 22 especially especially RB cord-300850-59j1m2tm 122 23 in in IN cord-300850-59j1m2tm 122 24 the the DT cord-300850-59j1m2tm 122 25 elderly elderly JJ cord-300850-59j1m2tm 122 26 population population NN cord-300850-59j1m2tm 122 27 that that WDT cord-300850-59j1m2tm 122 28 accounts account VBZ cord-300850-59j1m2tm 122 29 for for IN cord-300850-59j1m2tm 122 30 approximately approximately RB cord-300850-59j1m2tm 122 31 10 10 CD cord-300850-59j1m2tm 122 32 - - SYM cord-300850-59j1m2tm 122 33 12 12 CD cord-300850-59j1m2tm 122 34 % % NN cord-300850-59j1m2tm 122 35 of of IN cord-300850-59j1m2tm 122 36 the the DT cord-300850-59j1m2tm 122 37 mortality mortality NN cord-300850-59j1m2tm 122 38 rate rate NN cord-300850-59j1m2tm 122 39 . . . cord-300850-59j1m2tm 123 1 Here here RB cord-300850-59j1m2tm 123 2 , , , cord-300850-59j1m2tm 123 3 we -PRON- PRP cord-300850-59j1m2tm 123 4 present present VBP cord-300850-59j1m2tm 123 5 several several JJ cord-300850-59j1m2tm 123 6 relevant relevant JJ cord-300850-59j1m2tm 123 7 aspects aspect NNS cord-300850-59j1m2tm 123 8 that that WDT cord-300850-59j1m2tm 123 9 may may MD cord-300850-59j1m2tm 123 10 contribute contribute VB cord-300850-59j1m2tm 123 11 to to IN cord-300850-59j1m2tm 123 12 the the DT cord-300850-59j1m2tm 123 13 increased increase VBN cord-300850-59j1m2tm 123 14 susceptibility susceptibility NN cord-300850-59j1m2tm 123 15 of of IN cord-300850-59j1m2tm 123 16 the the DT cord-300850-59j1m2tm 123 17 aforementioned aforementioned JJ cord-300850-59j1m2tm 123 18 population population NN cord-300850-59j1m2tm 123 19 to to TO cord-300850-59j1m2tm 123 20 COVID-19 covid-19 VB cord-300850-59j1m2tm 123 21 . . . cord-300850-59j1m2tm 124 1 We -PRON- PRP cord-300850-59j1m2tm 124 2 believe believe VBP cord-300850-59j1m2tm 124 3 that that IN cord-300850-59j1m2tm 124 4 i i PRP cord-300850-59j1m2tm 124 5 ) ) -RRB- cord-300850-59j1m2tm 124 6 increased increase VBN cord-300850-59j1m2tm 124 7 expression expression NN cord-300850-59j1m2tm 124 8 of of IN cord-300850-59j1m2tm 124 9 ACE-2 ACE-2 NNP cord-300850-59j1m2tm 124 10 in in IN cord-300850-59j1m2tm 124 11 hypertensive hypertensive JJ cord-300850-59j1m2tm 124 12 patients patient NNS cord-300850-59j1m2tm 124 13 being be VBG cord-300850-59j1m2tm 124 14 treated treat VBN cord-300850-59j1m2tm 124 15 with with IN cord-300850-59j1m2tm 124 16 ACE ACE NNP cord-300850-59j1m2tm 124 17 inhibitors inhibitor NNS cord-300850-59j1m2tm 124 18 and and CC cord-300850-59j1m2tm 124 19 AT1R at1r CD cord-300850-59j1m2tm 124 20 blockers blocker NNS cord-300850-59j1m2tm 124 21 and and CC cord-300850-59j1m2tm 124 22 ii ii LS cord-300850-59j1m2tm 124 23 ) ) -RRB- cord-300850-59j1m2tm 124 24 previous previous JJ cord-300850-59j1m2tm 124 25 exposure exposure NN cord-300850-59j1m2tm 124 26 to to IN cord-300850-59j1m2tm 124 27 circulating circulate VBG cord-300850-59j1m2tm 124 28 coronaviruses coronaviruse NNS cord-300850-59j1m2tm 124 29 with with IN cord-300850-59j1m2tm 124 30 low low JJ cord-300850-59j1m2tm 124 31 neutralizing neutralize VBG cord-300850-59j1m2tm 124 32 capacity capacity NN cord-300850-59j1m2tm 124 33 to to IN cord-300850-59j1m2tm 124 34 SARS SARS NNP cord-300850-59j1m2tm 124 35 - - HYPH cord-300850-59j1m2tm 124 36 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 124 37 may may MD cord-300850-59j1m2tm 124 38 greatly greatly RB cord-300850-59j1m2tm 124 39 contribute contribute VB cord-300850-59j1m2tm 124 40 to to IN cord-300850-59j1m2tm 124 41 the the DT cord-300850-59j1m2tm 124 42 increased increase VBN cord-300850-59j1m2tm 124 43 susceptibility susceptibility NN cord-300850-59j1m2tm 124 44 of of IN cord-300850-59j1m2tm 124 45 the the DT cord-300850-59j1m2tm 124 46 elderly elderly JJ cord-300850-59j1m2tm 124 47 patients patient NNS cord-300850-59j1m2tm 124 48 to to TO cord-300850-59j1m2tm 124 49 COVID-19 covid-19 VB cord-300850-59j1m2tm 124 50 . . . cord-300850-59j1m2tm 125 1 To to TO cord-300850-59j1m2tm 125 2 determine determine VB cord-300850-59j1m2tm 125 3 whether whether IN cord-300850-59j1m2tm 125 4 these these DT cord-300850-59j1m2tm 125 5 hypotheses hypothesis NNS cord-300850-59j1m2tm 125 6 are be VBP cord-300850-59j1m2tm 125 7 correct correct JJ cord-300850-59j1m2tm 125 8 , , , cord-300850-59j1m2tm 125 9 further further JJ cord-300850-59j1m2tm 125 10 investigations investigation NNS cord-300850-59j1m2tm 125 11 are be VBP cord-300850-59j1m2tm 125 12 needed need VBN cord-300850-59j1m2tm 125 13 , , , cord-300850-59j1m2tm 125 14 not not RB cord-300850-59j1m2tm 125 15 only only RB cord-300850-59j1m2tm 125 16 to to TO cord-300850-59j1m2tm 125 17 better better RB cord-300850-59j1m2tm 125 18 understand understand VB cord-300850-59j1m2tm 125 19 the the DT cord-300850-59j1m2tm 125 20 etiology etiology NN cord-300850-59j1m2tm 125 21 of of IN cord-300850-59j1m2tm 125 22 the the DT cord-300850-59j1m2tm 125 23 current current JJ cord-300850-59j1m2tm 125 24 SARS SARS NNP cord-300850-59j1m2tm 125 25 - - HYPH cord-300850-59j1m2tm 125 26 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 125 27 infection infection NN cord-300850-59j1m2tm 125 28 , , , cord-300850-59j1m2tm 125 29 but but CC cord-300850-59j1m2tm 125 30 also also RB cord-300850-59j1m2tm 125 31 to to TO cord-300850-59j1m2tm 125 32 be be VB cord-300850-59j1m2tm 125 33 better well RBR cord-300850-59j1m2tm 125 34 prepared prepare VBN cord-300850-59j1m2tm 125 35 for for IN cord-300850-59j1m2tm 125 36 future future JJ cord-300850-59j1m2tm 125 37 epidemics epidemic NNS cord-300850-59j1m2tm 125 38 . . . cord-300850-59j1m2tm 125 39 ' ' '' cord-300850-59j1m2tm 126 1 AUTHOR author NN cord-300850-59j1m2tm 126 2 CONTRIBUTIONS CONTRIBUTIONS NNP cord-300850-59j1m2tm 126 3 Peron Peron NNP cord-300850-59j1m2tm 126 4 JPS JPS NNP cord-300850-59j1m2tm 126 5 conceived conceive VBD cord-300850-59j1m2tm 126 6 and and CC cord-300850-59j1m2tm 126 7 wrote write VBD cord-300850-59j1m2tm 126 8 the the DT cord-300850-59j1m2tm 126 9 manuscript manuscript NN cord-300850-59j1m2tm 126 10 . . . cord-300850-59j1m2tm 127 1 Nakaya Nakaya NNP cord-300850-59j1m2tm 127 2 H H NNP cord-300850-59j1m2tm 127 3 helped help VBD cord-300850-59j1m2tm 127 4 editing edit VBG cord-300850-59j1m2tm 127 5 the the DT cord-300850-59j1m2tm 127 6 manuscript manuscript NN cord-300850-59j1m2tm 127 7 . . . cord-300850-59j1m2tm 128 1 A a DT cord-300850-59j1m2tm 128 2 pneumonia pneumonia NN cord-300850-59j1m2tm 128 3 outbreak outbreak NN cord-300850-59j1m2tm 128 4 associated associate VBN cord-300850-59j1m2tm 128 5 with with IN cord-300850-59j1m2tm 128 6 a a DT cord-300850-59j1m2tm 128 7 new new JJ cord-300850-59j1m2tm 128 8 coronavirus coronavirus NN cord-300850-59j1m2tm 128 9 of of IN cord-300850-59j1m2tm 128 10 probable probable JJ cord-300850-59j1m2tm 128 11 bat bat NN cord-300850-59j1m2tm 128 12 origin origin NN cord-300850-59j1m2tm 129 1 A a DT cord-300850-59j1m2tm 129 2 new new JJ cord-300850-59j1m2tm 129 3 coronavirus coronavirus NN cord-300850-59j1m2tm 129 4 associated associate VBN cord-300850-59j1m2tm 129 5 with with IN cord-300850-59j1m2tm 129 6 human human JJ cord-300850-59j1m2tm 129 7 respiratory respiratory JJ cord-300850-59j1m2tm 129 8 disease disease NN cord-300850-59j1m2tm 129 9 in in IN cord-300850-59j1m2tm 129 10 China China NNP cord-300850-59j1m2tm 129 11 Genomic Genomic NNP cord-300850-59j1m2tm 129 12 characterisation characterisation NN cord-300850-59j1m2tm 129 13 and and CC cord-300850-59j1m2tm 129 14 epidemiology epidemiology NN cord-300850-59j1m2tm 129 15 of of IN cord-300850-59j1m2tm 129 16 2019 2019 CD cord-300850-59j1m2tm 129 17 novel novel JJ cord-300850-59j1m2tm 129 18 coronavirus coronavirus NN cord-300850-59j1m2tm 129 19 : : : cord-300850-59j1m2tm 129 20 implications implication NNS cord-300850-59j1m2tm 129 21 for for IN cord-300850-59j1m2tm 129 22 virus virus NN cord-300850-59j1m2tm 129 23 origins origin NNS cord-300850-59j1m2tm 129 24 and and CC cord-300850-59j1m2tm 129 25 receptor receptor NN cord-300850-59j1m2tm 129 26 binding bind VBG cord-300850-59j1m2tm 129 27 Clinical Clinical NNP cord-300850-59j1m2tm 129 28 Characteristics characteristic NNS cord-300850-59j1m2tm 129 29 of of IN cord-300850-59j1m2tm 129 30 Coronavirus Coronavirus NNP cord-300850-59j1m2tm 129 31 Disease Disease NNP cord-300850-59j1m2tm 129 32 2019 2019 CD cord-300850-59j1m2tm 129 33 in in IN cord-300850-59j1m2tm 129 34 China China NNP cord-300850-59j1m2tm 129 35 Risk Risk NNP cord-300850-59j1m2tm 129 36 Factors Factors NNP cord-300850-59j1m2tm 129 37 Associated Associated NNP cord-300850-59j1m2tm 129 38 With with IN cord-300850-59j1m2tm 129 39 Acute acute JJ cord-300850-59j1m2tm 129 40 Respiratory respiratory JJ cord-300850-59j1m2tm 129 41 Distress Distress NNP cord-300850-59j1m2tm 129 42 Syndrome Syndrome NNP cord-300850-59j1m2tm 129 43 and and CC cord-300850-59j1m2tm 129 44 Death death NN cord-300850-59j1m2tm 129 45 in in IN cord-300850-59j1m2tm 129 46 Patients Patients NNP cord-300850-59j1m2tm 129 47 With with IN cord-300850-59j1m2tm 129 48 Coronavirus Coronavirus NNP cord-300850-59j1m2tm 129 49 Disease Disease NNP cord-300850-59j1m2tm 129 50 Global global JJ cord-300850-59j1m2tm 129 51 burden burden NN cord-300850-59j1m2tm 129 52 of of IN cord-300850-59j1m2tm 129 53 respiratory respiratory JJ cord-300850-59j1m2tm 129 54 infections infection NNS cord-300850-59j1m2tm 129 55 associated associate VBN cord-300850-59j1m2tm 129 56 with with IN cord-300850-59j1m2tm 129 57 seasonal seasonal JJ cord-300850-59j1m2tm 129 58 influenza influenza NN cord-300850-59j1m2tm 129 59 in in IN cord-300850-59j1m2tm 129 60 children child NNS cord-300850-59j1m2tm 129 61 under under IN cord-300850-59j1m2tm 129 62 5 5 CD cord-300850-59j1m2tm 129 63 years year NNS cord-300850-59j1m2tm 129 64 in in IN cord-300850-59j1m2tm 129 65 2018 2018 CD cord-300850-59j1m2tm 129 66 : : : cord-300850-59j1m2tm 129 67 a a DT cord-300850-59j1m2tm 129 68 systematic systematic JJ cord-300850-59j1m2tm 129 69 review review NN cord-300850-59j1m2tm 129 70 and and CC cord-300850-59j1m2tm 129 71 modelling modelling NN cord-300850-59j1m2tm 129 72 study study NN cord-300850-59j1m2tm 129 73 Angiotensin Angiotensin NNP cord-300850-59j1m2tm 129 74 - - HYPH cord-300850-59j1m2tm 129 75 converting convert VBG cord-300850-59j1m2tm 129 76 enzyme enzyme NN cord-300850-59j1m2tm 129 77 2 2 CD cord-300850-59j1m2tm 129 78 is be VBZ cord-300850-59j1m2tm 129 79 a a DT cord-300850-59j1m2tm 129 80 functional functional JJ cord-300850-59j1m2tm 129 81 receptor receptor NN cord-300850-59j1m2tm 129 82 for for IN cord-300850-59j1m2tm 129 83 the the DT cord-300850-59j1m2tm 129 84 SARS SARS NNP cord-300850-59j1m2tm 129 85 coronavirus coronavirus NN cord-300850-59j1m2tm 129 86 Tissue tissue NN cord-300850-59j1m2tm 129 87 distribution distribution NN cord-300850-59j1m2tm 129 88 of of IN cord-300850-59j1m2tm 129 89 ACE2 ACE2 NNP cord-300850-59j1m2tm 129 90 protein protein NN cord-300850-59j1m2tm 129 91 , , , cord-300850-59j1m2tm 129 92 the the DT cord-300850-59j1m2tm 129 93 functional functional JJ cord-300850-59j1m2tm 129 94 receptor receptor NN cord-300850-59j1m2tm 129 95 for for IN cord-300850-59j1m2tm 129 96 SARS SARS NNP cord-300850-59j1m2tm 129 97 coronavirus coronavirus NN cord-300850-59j1m2tm 129 98 . . . cord-300850-59j1m2tm 130 1 A a DT cord-300850-59j1m2tm 130 2 first first JJ cord-300850-59j1m2tm 130 3 step step NN cord-300850-59j1m2tm 130 4 in in IN cord-300850-59j1m2tm 130 5 understanding understand VBG cord-300850-59j1m2tm 130 6 SARS SARS NNP cord-300850-59j1m2tm 130 7 pathogenesis pathogenesis NN cord-300850-59j1m2tm 130 8 Epidemiologic Epidemiologic NNP cord-300850-59j1m2tm 130 9 Features Features NNPS cord-300850-59j1m2tm 130 10 and and CC cord-300850-59j1m2tm 130 11 Clinical Clinical NNP cord-300850-59j1m2tm 130 12 Course course NN cord-300850-59j1m2tm 130 13 of of IN cord-300850-59j1m2tm 130 14 Patients patient NNS cord-300850-59j1m2tm 130 15 Infected infect VBN cord-300850-59j1m2tm 130 16 With with IN cord-300850-59j1m2tm 130 17 SARS SARS NNP cord-300850-59j1m2tm 130 18 - - HYPH cord-300850-59j1m2tm 130 19 CoV-2 CoV-2 NNP cord-300850-59j1m2tm 130 20 in in IN cord-300850-59j1m2tm 130 21 Singapore Singapore NNP cord-300850-59j1m2tm 130 22 Angiotensin Angiotensin NNP cord-300850-59j1m2tm 130 23 - - HYPH cord-300850-59j1m2tm 130 24 converting convert VBG cord-300850-59j1m2tm 130 25 enzyme enzyme NN cord-300850-59j1m2tm 131 1 2 2 CD cord-300850-59j1m2tm 131 2 is be VBZ cord-300850-59j1m2tm 131 3 an an DT cord-300850-59j1m2tm 131 4 essential essential JJ cord-300850-59j1m2tm 131 5 regulator regulator NN cord-300850-59j1m2tm 131 6 of of IN cord-300850-59j1m2tm 131 7 heart heart NN cord-300850-59j1m2tm 131 8 function function NN cord-300850-59j1m2tm 132 1 Angiotensinconverting angiotensinconverting NN cord-300850-59j1m2tm 132 2 enzyme enzyme NN cord-300850-59j1m2tm 132 3 2 2 CD cord-300850-59j1m2tm 132 4 and and CC cord-300850-59j1m2tm 132 5 angiotensin angiotensin NN cord-300850-59j1m2tm 132 6 1 1 CD cord-300850-59j1m2tm 132 7 - - SYM cord-300850-59j1m2tm 132 8 7 7 CD cord-300850-59j1m2tm 132 9 : : : cord-300850-59j1m2tm 132 10 novel novel JJ cord-300850-59j1m2tm 132 11 therapeutic therapeutic JJ cord-300850-59j1m2tm 132 12 targets target NNS cord-300850-59j1m2tm 133 1 Anti anti JJ cord-300850-59j1m2tm 133 2 - - JJ cord-300850-59j1m2tm 133 3 Hypertensive hypertensive JJ cord-300850-59j1m2tm 133 4 Medication Medication NNP cord-300850-59j1m2tm 133 5 Combinations Combinations NNPS cord-300850-59j1m2tm 133 6 in in IN cord-300850-59j1m2tm 133 7 the the DT cord-300850-59j1m2tm 133 8 United United NNP cord-300850-59j1m2tm 133 9 States States NNP cord-300850-59j1m2tm 133 10 Effect Effect NNP cord-300850-59j1m2tm 133 11 of of IN cord-300850-59j1m2tm 133 12 angiotensin angiotensin NN cord-300850-59j1m2tm 133 13 - - HYPH cord-300850-59j1m2tm 133 14 converting convert VBG cord-300850-59j1m2tm 133 15 enzyme enzyme NN cord-300850-59j1m2tm 133 16 inhibition inhibition NN cord-300850-59j1m2tm 133 17 and and CC cord-300850-59j1m2tm 133 18 angiotensin angiotensin NN cord-300850-59j1m2tm 133 19 II ii CD cord-300850-59j1m2tm 133 20 receptor receptor NN cord-300850-59j1m2tm 133 21 blockers blocker NNS cord-300850-59j1m2tm 133 22 on on IN cord-300850-59j1m2tm 133 23 cardiac cardiac JJ cord-300850-59j1m2tm 133 24 angiotensin angiotensin NN cord-300850-59j1m2tm 133 25 - - HYPH cord-300850-59j1m2tm 133 26 converting convert VBG cord-300850-59j1m2tm 133 27 enzyme enzyme NN cord-300850-59j1m2tm 134 1 2 2 CD cord-300850-59j1m2tm 134 2 Upregulation Upregulation NNP cord-300850-59j1m2tm 134 3 of of IN cord-300850-59j1m2tm 134 4 angiotensin angiotensin NN cord-300850-59j1m2tm 134 5 - - HYPH cord-300850-59j1m2tm 134 6 converting convert VBG cord-300850-59j1m2tm 134 7 enzyme enzyme NN cord-300850-59j1m2tm 134 8 2 2 CD cord-300850-59j1m2tm 134 9 after after IN cord-300850-59j1m2tm 134 10 myocardial myocardial JJ cord-300850-59j1m2tm 134 11 infarction infarction NN cord-300850-59j1m2tm 134 12 by by IN cord-300850-59j1m2tm 134 13 blockade blockade NN cord-300850-59j1m2tm 134 14 of of IN cord-300850-59j1m2tm 134 15 angiotensin angiotensin NN cord-300850-59j1m2tm 134 16 II II NNP cord-300850-59j1m2tm 134 17 receptors receptor NNS cord-300850-59j1m2tm 134 18 Olmesartan Olmesartan NNP cord-300850-59j1m2tm 134 19 is be VBZ cord-300850-59j1m2tm 134 20 an an DT cord-300850-59j1m2tm 134 21 angiotensin angiotensin NN cord-300850-59j1m2tm 134 22 II ii CD cord-300850-59j1m2tm 134 23 receptor receptor NN cord-300850-59j1m2tm 134 24 blocker blocker NN cord-300850-59j1m2tm 134 25 with with IN cord-300850-59j1m2tm 134 26 an an DT cord-300850-59j1m2tm 134 27 inhibitory inhibitory JJ cord-300850-59j1m2tm 134 28 effect effect NN cord-300850-59j1m2tm 134 29 on on IN cord-300850-59j1m2tm 134 30 angiotensin angiotensin NN cord-300850-59j1m2tm 134 31 - - HYPH cord-300850-59j1m2tm 134 32 converting convert VBG cord-300850-59j1m2tm 134 33 enzyme enzyme NN cord-300850-59j1m2tm 134 34 Upregulation Upregulation NNP cord-300850-59j1m2tm 134 35 of of IN cord-300850-59j1m2tm 134 36 angiotensin angiotensin NN cord-300850-59j1m2tm 134 37 - - HYPH cord-300850-59j1m2tm 134 38 converting convert VBG cord-300850-59j1m2tm 134 39 enzyme enzyme NN cord-300850-59j1m2tm 134 40 ( ( -LRB- cord-300850-59j1m2tm 134 41 ACE ace NN cord-300850-59j1m2tm 134 42 ) ) -RRB- cord-300850-59j1m2tm 134 43 2 2 CD cord-300850-59j1m2tm 134 44 in in IN cord-300850-59j1m2tm 134 45 hepatic hepatic JJ cord-300850-59j1m2tm 134 46 fibrosis fibrosis NN cord-300850-59j1m2tm 134 47 by by IN cord-300850-59j1m2tm 134 48 ACE ACE NNP cord-300850-59j1m2tm 134 49 inhibitors inhibitor NNS cord-300850-59j1m2tm 134 50 Tumor tumor NN cord-300850-59j1m2tm 134 51 necrosis necrosis NN cord-300850-59j1m2tm 134 52 factor factor NN cord-300850-59j1m2tm 134 53 - - HYPH cord-300850-59j1m2tm 134 54 alpha alpha NN cord-300850-59j1m2tm 134 55 convertase convertase NN cord-300850-59j1m2tm 134 56 ( ( -LRB- cord-300850-59j1m2tm 134 57 ADAM17 adam17 NN cord-300850-59j1m2tm 134 58 ) ) -RRB- cord-300850-59j1m2tm 135 1 mediates mediate VBZ cord-300850-59j1m2tm 135 2 regulated regulate VBN cord-300850-59j1m2tm 135 3 ectodomain ectodomain NN cord-300850-59j1m2tm 135 4 shedding shedding NN cord-300850-59j1m2tm 135 5 of of IN cord-300850-59j1m2tm 135 6 the the DT cord-300850-59j1m2tm 135 7 severe severe JJ cord-300850-59j1m2tm 135 8 - - HYPH cord-300850-59j1m2tm 135 9 acute acute JJ cord-300850-59j1m2tm 135 10 respiratory respiratory JJ cord-300850-59j1m2tm 135 11 syndromecoronavirus syndromecoronavirus NNP cord-300850-59j1m2tm 135 12 ( ( -LRB- cord-300850-59j1m2tm 135 13 SARS SARS NNP cord-300850-59j1m2tm 135 14 - - HYPH cord-300850-59j1m2tm 135 15 CoV CoV NNP cord-300850-59j1m2tm 135 16 ) ) -RRB- cord-300850-59j1m2tm 135 17 receptor receptor NN cord-300850-59j1m2tm 135 18 , , , cord-300850-59j1m2tm 136 1 angiotensin angiotensin NN cord-300850-59j1m2tm 136 2 - - HYPH cord-300850-59j1m2tm 136 3 converting convert VBG cord-300850-59j1m2tm 136 4 enzyme-2 enzyme-2 NNP cord-300850-59j1m2tm 136 5 ( ( -LRB- cord-300850-59j1m2tm 136 6 ACE2 ACE2 NNP cord-300850-59j1m2tm 136 7 ) ) -RRB- cord-300850-59j1m2tm 136 8 Detection detection NN cord-300850-59j1m2tm 136 9 of of IN cord-300850-59j1m2tm 136 10 soluble soluble JJ cord-300850-59j1m2tm 136 11 angiotensin angiotensin NN cord-300850-59j1m2tm 136 12 - - HYPH cord-300850-59j1m2tm 136 13 converting convert VBG cord-300850-59j1m2tm 136 14 enzyme enzyme NN cord-300850-59j1m2tm 136 15 2 2 CD cord-300850-59j1m2tm 136 16 in in IN cord-300850-59j1m2tm 136 17 heart heart NN cord-300850-59j1m2tm 136 18 failure failure NN cord-300850-59j1m2tm 136 19 : : : cord-300850-59j1m2tm 136 20 insights insight NNS cord-300850-59j1m2tm 136 21 into into IN cord-300850-59j1m2tm 136 22 the the DT cord-300850-59j1m2tm 136 23 endogenous endogenous JJ cord-300850-59j1m2tm 136 24 counter counter JJ cord-300850-59j1m2tm 136 25 - - JJ cord-300850-59j1m2tm 136 26 regulatory regulatory JJ cord-300850-59j1m2tm 136 27 pathway pathway NN cord-300850-59j1m2tm 136 28 of of IN cord-300850-59j1m2tm 136 29 the the DT cord-300850-59j1m2tm 136 30 renin renin NN cord-300850-59j1m2tm 136 31 - - HYPH cord-300850-59j1m2tm 136 32 angiotensinaldosterone angiotensinaldosterone NN cord-300850-59j1m2tm 136 33 system system NN cord-300850-59j1m2tm 136 34 Clinical Clinical NNP cord-300850-59j1m2tm 136 35 Relevance Relevance NNP cord-300850-59j1m2tm 136 36 and and CC cord-300850-59j1m2tm 136 37 Role role NN cord-300850-59j1m2tm 136 38 of of IN cord-300850-59j1m2tm 136 39 Neuronal Neuronal NNP cord-300850-59j1m2tm 137 1 AT at IN cord-300850-59j1m2tm 137 2 1 1 CD cord-300850-59j1m2tm 137 3 Receptors receptor NNS cord-300850-59j1m2tm 137 4 in in IN cord-300850-59j1m2tm 137 5 ADAM17-Mediated ADAM17-Mediated NNP cord-300850-59j1m2tm 137 6 ACE2 ACE2 NNP cord-300850-59j1m2tm 137 7 Shedding shed VBG cord-300850-59j1m2tm 137 8 in in IN cord-300850-59j1m2tm 137 9 Neurogenic neurogenic JJ cord-300850-59j1m2tm 137 10 Hypertension Hypertension NNP cord-300850-59j1m2tm 137 11 Modulation Modulation NNP cord-300850-59j1m2tm 137 12 of of IN cord-300850-59j1m2tm 137 13 TNF tnf NN cord-300850-59j1m2tm 137 14 - - HYPH cord-300850-59j1m2tm 137 15 alpha alpha NN cord-300850-59j1m2tm 137 16 - - HYPH cord-300850-59j1m2tm 137 17 converting convert VBG cord-300850-59j1m2tm 137 18 enzyme enzyme NN cord-300850-59j1m2tm 137 19 by by IN cord-300850-59j1m2tm 137 20 the the DT cord-300850-59j1m2tm 137 21 spike spike NN cord-300850-59j1m2tm 137 22 protein protein NN cord-300850-59j1m2tm 137 23 of of IN cord-300850-59j1m2tm 137 24 SARS SARS NNP cord-300850-59j1m2tm 137 25 - - HYPH cord-300850-59j1m2tm 137 26 CoV CoV NNP cord-300850-59j1m2tm 137 27 and and CC cord-300850-59j1m2tm 137 28 ACE2 ACE2 NNP cord-300850-59j1m2tm 137 29 induces induce VBZ cord-300850-59j1m2tm 137 30 TNF tnf NN cord-300850-59j1m2tm 137 31 - - HYPH cord-300850-59j1m2tm 137 32 alpha alpha NN cord-300850-59j1m2tm 137 33 production production NN cord-300850-59j1m2tm 137 34 and and CC cord-300850-59j1m2tm 137 35 facilitates facilitate VBZ cord-300850-59j1m2tm 137 36 viral viral JJ cord-300850-59j1m2tm 137 37 entry entry NN cord-300850-59j1m2tm 137 38 Ectodomain Ectodomain NNP cord-300850-59j1m2tm 137 39 shedding shed VBG cord-300850-59j1m2tm 137 40 of of IN cord-300850-59j1m2tm 137 41 angiotensin angiotensin NN cord-300850-59j1m2tm 137 42 converting convert VBG cord-300850-59j1m2tm 137 43 enzyme enzyme NN cord-300850-59j1m2tm 137 44 2 2 CD cord-300850-59j1m2tm 137 45 in in IN cord-300850-59j1m2tm 137 46 human human JJ cord-300850-59j1m2tm 137 47 airway airway NN cord-300850-59j1m2tm 137 48 epithelia epithelium NNS cord-300850-59j1m2tm 137 49 Receptor Receptor NNP cord-300850-59j1m2tm 137 50 Recognition Recognition NNP cord-300850-59j1m2tm 137 51 by by IN cord-300850-59j1m2tm 137 52 the the DT cord-300850-59j1m2tm 137 53 Novel Novel NNP cord-300850-59j1m2tm 137 54 Coronavirus Coronavirus NNP cord-300850-59j1m2tm 137 55 from from IN cord-300850-59j1m2tm 137 56 Wuhan Wuhan NNP cord-300850-59j1m2tm 137 57 : : : cord-300850-59j1m2tm 137 58 an an DT cord-300850-59j1m2tm 137 59 Analysis Analysis NNP cord-300850-59j1m2tm 137 60 Based base VBN cord-300850-59j1m2tm 137 61 on on IN cord-300850-59j1m2tm 137 62 Decade decade NN cord-300850-59j1m2tm 137 63 - - HYPH cord-300850-59j1m2tm 137 64 Long Long NNP cord-300850-59j1m2tm 137 65 Structural Structural NNP cord-300850-59j1m2tm 137 66 Studies Studies NNPS cord-300850-59j1m2tm 137 67 of of IN cord-300850-59j1m2tm 137 68 SARS SARS NNP cord-300850-59j1m2tm 137 69 Coronavirus Coronavirus NNP cord-300850-59j1m2tm 137 70 TACE TACE NNP cord-300850-59j1m2tm 137 71 antagonists antagonist NNS cord-300850-59j1m2tm 137 72 blocking block VBG cord-300850-59j1m2tm 137 73 ACE2 ACE2 NNP cord-300850-59j1m2tm 137 74 shedding shedding NN cord-300850-59j1m2tm 137 75 caused cause VBN cord-300850-59j1m2tm 137 76 by by IN cord-300850-59j1m2tm 137 77 the the DT cord-300850-59j1m2tm 137 78 spike spike NN cord-300850-59j1m2tm 137 79 protein protein NN cord-300850-59j1m2tm 137 80 of of IN cord-300850-59j1m2tm 137 81 SARS SARS NNP cord-300850-59j1m2tm 137 82 - - HYPH cord-300850-59j1m2tm 137 83 CoV CoV NNP cord-300850-59j1m2tm 137 84 are be VBP cord-300850-59j1m2tm 137 85 candidate candidate NN cord-300850-59j1m2tm 137 86 antiviral antiviral JJ cord-300850-59j1m2tm 137 87 compounds compound NNS cord-300850-59j1m2tm 137 88 Inhibition Inhibition NNP cord-300850-59j1m2tm 137 89 of of IN cord-300850-59j1m2tm 137 90 dengue dengue NN cord-300850-59j1m2tm 137 91 and and CC cord-300850-59j1m2tm 137 92 chikungunya chikungunya NN cord-300850-59j1m2tm 137 93 virus virus NN cord-300850-59j1m2tm 137 94 infections infection NNS cord-300850-59j1m2tm 137 95 by by IN cord-300850-59j1m2tm 137 96 RIG rig NN cord-300850-59j1m2tm 137 97 - - HYPH cord-300850-59j1m2tm 137 98 I i NN cord-300850-59j1m2tm 137 99 - - HYPH cord-300850-59j1m2tm 137 100 mediated mediate VBN cord-300850-59j1m2tm 137 101 type type NN cord-300850-59j1m2tm 138 1 I -PRON- PRP cord-300850-59j1m2tm 138 2 interferon interferon NN cord-300850-59j1m2tm 138 3 - - HYPH cord-300850-59j1m2tm 138 4 independent independent JJ cord-300850-59j1m2tm 138 5 stimulation stimulation NN cord-300850-59j1m2tm 138 6 of of IN cord-300850-59j1m2tm 138 7 the the DT cord-300850-59j1m2tm 138 8 innate innate JJ cord-300850-59j1m2tm 138 9 antiviral antiviral JJ cord-300850-59j1m2tm 138 10 response response NN cord-300850-59j1m2tm 139 1 The the DT cord-300850-59j1m2tm 139 2 Brazilian brazilian JJ cord-300850-59j1m2tm 139 3 Zika Zika NNP cord-300850-59j1m2tm 139 4 virus virus NN cord-300850-59j1m2tm 139 5 strain strain NN cord-300850-59j1m2tm 139 6 causes cause VBZ cord-300850-59j1m2tm 139 7 birth birth NN cord-300850-59j1m2tm 139 8 defects defect NNS cord-300850-59j1m2tm 139 9 in in IN cord-300850-59j1m2tm 139 10 experimental experimental JJ cord-300850-59j1m2tm 139 11 models model NNS cord-300850-59j1m2tm 139 12 Enhancement Enhancement NNP cord-300850-59j1m2tm 139 13 of of IN cord-300850-59j1m2tm 139 14 Zika Zika NNP cord-300850-59j1m2tm 139 15 virus virus NN cord-300850-59j1m2tm 139 16 pathogenesis pathogenesis NN cord-300850-59j1m2tm 139 17 by by IN cord-300850-59j1m2tm 139 18 preexisting preexist VBG cord-300850-59j1m2tm 139 19 antiflavivirus antiflavivirus NN cord-300850-59j1m2tm 139 20 immunity immunity NN cord-300850-59j1m2tm 139 21 Dengue Dengue NNP cord-300850-59j1m2tm 139 22 virus virus NN cord-300850-59j1m2tm 139 23 sero sero NN cord-300850-59j1m2tm 139 24 - - HYPH cord-300850-59j1m2tm 139 25 cross cross NN cord-300850-59j1m2tm 139 26 - - NN cord-300850-59j1m2tm 139 27 reactivity reactivity JJ cord-300850-59j1m2tm 139 28 drives drive NNS cord-300850-59j1m2tm 139 29 antibodydependent antibodydependent NN cord-300850-59j1m2tm 139 30 enhancement enhancement NN cord-300850-59j1m2tm 139 31 of of IN cord-300850-59j1m2tm 139 32 infection infection NN cord-300850-59j1m2tm 139 33 with with IN cord-300850-59j1m2tm 139 34 zika zika NNP cord-300850-59j1m2tm 139 35 virus virus NN cord-300850-59j1m2tm 139 36 Viral Viral NNP cord-300850-59j1m2tm 139 37 Load Load NNP cord-300850-59j1m2tm 139 38 and and CC cord-300850-59j1m2tm 139 39 Cytokine Cytokine NNP cord-300850-59j1m2tm 139 40 Response response NN cord-300850-59j1m2tm 139 41 Profile Profile NNP cord-300850-59j1m2tm 140 1 Does do VBZ cord-300850-59j1m2tm 140 2 Not not RB cord-300850-59j1m2tm 140 3 Support Support NNP cord-300850-59j1m2tm 140 4 Antibody Antibody NNP cord-300850-59j1m2tm 140 5 - - HYPH cord-300850-59j1m2tm 140 6 Dependent Dependent NNP cord-300850-59j1m2tm 140 7 Enhancement Enhancement NNP cord-300850-59j1m2tm 140 8 in in IN cord-300850-59j1m2tm 140 9 Dengue dengue NN cord-300850-59j1m2tm 140 10 - - HYPH cord-300850-59j1m2tm 140 11 Primed prime VBN cord-300850-59j1m2tm 140 12 Zika Zika NNP cord-300850-59j1m2tm 140 13 Virus virus NN cord-300850-59j1m2tm 140 14 - - HYPH cord-300850-59j1m2tm 140 15 Infected infect VBN cord-300850-59j1m2tm 140 16 Patients Patients NNP cord-300850-59j1m2tm 140 17 Antibody Antibody NNP cord-300850-59j1m2tm 140 18 - - HYPH cord-300850-59j1m2tm 140 19 Dependent Dependent NNP cord-300850-59j1m2tm 140 20 Enhancement Enhancement NNP cord-300850-59j1m2tm 140 21 of of IN cord-300850-59j1m2tm 140 22 Ebola Ebola NNP cord-300850-59j1m2tm 140 23 Virus Virus NNP cord-300850-59j1m2tm 140 24 Infection Infection NNP cord-300850-59j1m2tm 140 25 by by IN cord-300850-59j1m2tm 140 26 Human Human NNP cord-300850-59j1m2tm 140 27 Antibodies Antibodies NNPS cord-300850-59j1m2tm 140 28 Isolated isolate VBN cord-300850-59j1m2tm 140 29 from from IN cord-300850-59j1m2tm 140 30 Survivors Survivors NNPS cord-300850-59j1m2tm 140 31 Extensive extensive JJ cord-300850-59j1m2tm 140 32 complement complement NN cord-300850-59j1m2tm 140 33 - - HYPH cord-300850-59j1m2tm 140 34 dependent dependent JJ cord-300850-59j1m2tm 140 35 enhancement enhancement NN cord-300850-59j1m2tm 140 36 of of IN cord-300850-59j1m2tm 140 37 HIV-1 HIV-1 NNP cord-300850-59j1m2tm 140 38 by by IN cord-300850-59j1m2tm 140 39 autologous autologous JJ cord-300850-59j1m2tm 140 40 non non JJ cord-300850-59j1m2tm 140 41 - - JJ cord-300850-59j1m2tm 140 42 neutralising neutralising JJ cord-300850-59j1m2tm 140 43 antibodies antibody NNS cord-300850-59j1m2tm 140 44 at at IN cord-300850-59j1m2tm 140 45 early early JJ cord-300850-59j1m2tm 140 46 stages stage NNS cord-300850-59j1m2tm 140 47 of of IN cord-300850-59j1m2tm 140 48 infection infection NN cord-300850-59j1m2tm 140 49 Highlights Highlights NNPS cord-300850-59j1m2tm 140 50 for for IN cord-300850-59j1m2tm 140 51 Dengue Dengue NNP cord-300850-59j1m2tm 140 52 Immunopathogenesis Immunopathogenesis NNP cord-300850-59j1m2tm 140 53 : : : cord-300850-59j1m2tm 140 54 Antibody antibody NN cord-300850-59j1m2tm 140 55 - - HYPH cord-300850-59j1m2tm 140 56 Dependent Dependent NNP cord-300850-59j1m2tm 140 57 Enhancement Enhancement NNP cord-300850-59j1m2tm 140 58 , , , cord-300850-59j1m2tm 140 59 Cytokine Cytokine NNP cord-300850-59j1m2tm 140 60 Storm storm NN cord-300850-59j1m2tm 140 61 , , , cord-300850-59j1m2tm 140 62 and and CC cord-300850-59j1m2tm 140 63 Beyond Beyond NNP cord-300850-59j1m2tm 140 64 Functions Functions NNPS cord-300850-59j1m2tm 140 65 of of IN cord-300850-59j1m2tm 140 66 TAM TAM NNP cord-300850-59j1m2tm 140 67 RTKs rtk NNS cord-300850-59j1m2tm 140 68 in in IN cord-300850-59j1m2tm 140 69 regulating regulate VBG cord-300850-59j1m2tm 140 70 spermatogenesis spermatogenesis NN cord-300850-59j1m2tm 140 71 and and CC cord-300850-59j1m2tm 140 72 male male JJ cord-300850-59j1m2tm 140 73 fertility fertility NN cord-300850-59j1m2tm 140 74 in in IN cord-300850-59j1m2tm 140 75 mice mouse NNS cord-300850-59j1m2tm 140 76 Anti anti JJ cord-300850-59j1m2tm 140 77 - - JJ cord-300850-59j1m2tm 140 78 spike spike JJ cord-300850-59j1m2tm 140 79 IgG igg NN cord-300850-59j1m2tm 140 80 causes cause VBZ cord-300850-59j1m2tm 140 81 severe severe JJ cord-300850-59j1m2tm 140 82 acute acute JJ cord-300850-59j1m2tm 140 83 lung lung NN cord-300850-59j1m2tm 140 84 injury injury NN cord-300850-59j1m2tm 140 85 by by IN cord-300850-59j1m2tm 140 86 skewing skew VBG cord-300850-59j1m2tm 140 87 macrophage macrophage NN cord-300850-59j1m2tm 140 88 responses response NNS cord-300850-59j1m2tm 140 89 during during IN cord-300850-59j1m2tm 140 90 acute acute JJ cord-300850-59j1m2tm 140 91 SARS SARS NNP cord-300850-59j1m2tm 140 92 - - HYPH cord-300850-59j1m2tm 140 93 CoV CoV NNP cord-300850-59j1m2tm 140 94 infection infection NN cord-300850-59j1m2tm 140 95 Antibody Antibody NNP cord-300850-59j1m2tm 140 96 responses response NNS cord-300850-59j1m2tm 140 97 against against IN cord-300850-59j1m2tm 140 98 SARS SARS NNP cord-300850-59j1m2tm 140 99 coronavirus coronavirus NN cord-300850-59j1m2tm 140 100 are be VBP cord-300850-59j1m2tm 140 101 correlated correlate VBN cord-300850-59j1m2tm 140 102 with with IN cord-300850-59j1m2tm 140 103 disease disease NN cord-300850-59j1m2tm 140 104 outcome outcome NN cord-300850-59j1m2tm 140 105 of of IN cord-300850-59j1m2tm 140 106 infected infected JJ cord-300850-59j1m2tm 140 107 individuals individual NNS cord-300850-59j1m2tm 140 108 Severe severe JJ cord-300850-59j1m2tm 140 109 pandemic pandemic NN cord-300850-59j1m2tm 140 110 2009 2009 CD cord-300850-59j1m2tm 140 111 H1N1 H1N1 NNP cord-300850-59j1m2tm 140 112 influenza influenza NN cord-300850-59j1m2tm 140 113 disease disease NN cord-300850-59j1m2tm 140 114 due due JJ cord-300850-59j1m2tm 140 115 to to IN cord-300850-59j1m2tm 140 116 pathogenic pathogenic JJ cord-300850-59j1m2tm 140 117 immune immune JJ cord-300850-59j1m2tm 140 118 complexes complex NNS cord-300850-59j1m2tm 141 1 Dipeptidyl Dipeptidyl NNP cord-300850-59j1m2tm 141 2 peptidase peptidase NN cord-300850-59j1m2tm 141 3 4 4 CD cord-300850-59j1m2tm 141 4 is be VBZ cord-300850-59j1m2tm 141 5 a a DT cord-300850-59j1m2tm 141 6 functional functional JJ cord-300850-59j1m2tm 141 7 receptor receptor NN cord-300850-59j1m2tm 141 8 for for IN cord-300850-59j1m2tm 141 9 the the DT cord-300850-59j1m2tm 141 10 emerging emerge VBG cord-300850-59j1m2tm 141 11 human human JJ cord-300850-59j1m2tm 141 12 coronavirus coronavirus NN cord-300850-59j1m2tm 141 13 - - HYPH cord-300850-59j1m2tm 141 14 EMC EMC NNP cord-300850-59j1m2tm 141 15 Immunodominant Immunodominant NNP cord-300850-59j1m2tm 141 16 SARS SARS NNP cord-300850-59j1m2tm 141 17 Coronavirus Coronavirus NNP cord-300850-59j1m2tm 141 18 Epitopes Epitopes NNP cord-300850-59j1m2tm 141 19 in in IN cord-300850-59j1m2tm 141 20 Humans Humans NNPS cord-300850-59j1m2tm 142 1 Elicited elicit VBN cord-300850-59j1m2tm 142 2 both both CC cord-300850-59j1m2tm 142 3 Enhancing enhance VBG cord-300850-59j1m2tm 142 4 and and CC cord-300850-59j1m2tm 142 5 Neutralizing neutralize VBG cord-300850-59j1m2tm 142 6 Effects effect NNS cord-300850-59j1m2tm 142 7 on on IN cord-300850-59j1m2tm 142 8 Infection infection NN cord-300850-59j1m2tm 142 9 in in IN cord-300850-59j1m2tm 142 10 Non non JJ cord-300850-59j1m2tm 142 11 - - JJ cord-300850-59j1m2tm 142 12 human human JJ cord-300850-59j1m2tm 142 13 Primates primate NNS